AC	ID	length (amino acids)	Number of 3D homologues	short name	full name
P0DTC3	AP3A_SARS2	275	12	ORF3a;	ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
P0DTC9	NCAP_SARS2	419	256	N; NC ;Protein N ;	Nucleoprotein ; Nucleocapsid protein ;
P0DTC6	NS6_SARS2	61	0	ORF6; ns6;	ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
P0DTC7	NS7A_SARS2	121	4	ORF7a;	ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
P0DTD8	NS7B_SARS2	43	0	ORF7b;	ORF7b protein; Accessory protein 7b;
P0DTC8	NS8_SARS2	121	9	ORF8; ns8;	ORF8 protein; Non-structural protein 8;
P0DTF1	ORF3B_SARS2	22	0	ORF3b;	Putative ORF3b protein ;
P0DTG1	ORF3C_SARS2	41	0	ORF3c; ORF3h;	ORF3c protein ; ORF3h protein ;
P0DTG0	ORF3D_SARS2	57	0		Putative ORF3d protein ;
P0DTD2	ORF9B_SARS2	97	20	ORF9b;	ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
P0DTD3	ORF9C_SARS2	73	0	ORF9c; ORF14;	Putative ORF9c protein ; Uncharacterized protein 14;
P0DTD1	R1AB_SARS2	7096	1500	pp1ab;	Replicase polyprotein 1ab; ORF1ab polyprotein;
P0DTC1	R1A_SARS2	4405	1500	pp1a;	Replicase polyprotein 1a; ORF1a polyprotein;
P0DTC2	SPIKE_SARS2	1273	1500	S glycoprotein ;	Spike glycoprotein ; E2 ;Peplomer protein ;
P0DTC4	VEMP_SARS2	75	18	E;sM protein ;	Envelope small membrane protein ;
P0DTC5	VME1_SARS2	222	12	M;	Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
P59632	AP3A_SARS	274	12		ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
P59595	NCAP_SARS	422	257	NC ;Protein N ;	Nucleoprotein ; Nucleocapsid protein ;
P59633	NS3B_SARS	154	0	ns3b;	ORF3b protein; Accessory protein 3b;Non-structural protein 3b;Protein X2;
P59634	NS6_SARS	63	0	ORF6; ns6;	ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
P59635	NS7A_SARS	122	4		ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
Q7TFA1	NS7B_SARS	44	0	ns7b;	Protein non-structural 7b; Accessory protein 7b;
Q7TFA0	NS8A_SARS	39	0	ns8a;	ORF8a protein; Accessory protein 8a;Protein non-structural 8a;
Q80H93	NS8B_SARS	84	0	ns8b;	ORF8b protein; Accessory protein 8b;Non-structural protein 8b;
P59636	ORF9B_SARS	98	20		ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
P0C6X7	R1AB_SARS	7073	1500	pp1ab;	Replicase polyprotein 1ab; ORF1ab polyprotein;
P0C6U8	R1A_SARS	4382	1500	pp1a;	Replicase polyprotein 1a; ORF1a polyprotein;
P59594	SPIKE_SARS	1255	1500	S glycoprotein ;	Spike glycoprotein ; E2 ;Peplomer protein ;
P59637	VEMP_SARS	76	18	E protein ;sM protein ;	Envelope small membrane protein ;
P59596	VME1_SARS	221	12	M protein ;	Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
Q7TLC7	Y14_SARS	70	0		Uncharacterized protein 14;
Q9BYF1	ACE2_HUMAN	805	594	ACEH ;ACE-related carboxypeptidase;	Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog ;Angiotensin-converting enzyme-related carboxypeptidase ;Metalloprotease MPROT15 {ECO:0000303|Ref.6};
P30556	AGTR1_HUMAN	359	1045	AT1 receptor ;	Type-1 angiotensin II receptor ; AT1AR ;AT1BR;Angiotensin II type-1 receptor ;
Q4KMQ2	ANO6_HUMAN	910	107	SCAN channel;	Anoctamin-6 ; Small-conductance calcium-activated nonselective cation channel;Transmembrane protein 16F;
P02649	APOE_HUMAN	317	38	Apo-E;	Apolipoprotein E ;
Q9NVJ2	ARL8B_HUMAN	186	1500		ADP-ribosylation factor-like protein 8B ; ADP-ribosylation factor-like protein 10C;Novel small G protein indispensable for equal chromosome segregation 1;
P17405	ASM_HUMAN	631	35	aSMase;	Sphingomyelin phosphodiesterase ; Acid sphingomyelinase {ECO:0000303|PubMed:25339683, ECO:0000303|PubMed:27349982, ECO:0000303|PubMed:33163980};
P35613	BASI_HUMAN	385	54	EMMPRIN;HAb18G ;TCSF;	Basigin ; 5F7;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;Hepatoma-associated antigen ;Leukocyte activation antigen M6;OK blood group antigen;Tumor cell-derived collagenase stimulatory factor;
O00327	BMAL1_HUMAN	626	166	bHLHe5;	Basic helix-loop-helix ARNT-like protein 1 ; Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3;
Q10589	BST2_HUMAN	180	47	BST-2;	Bone marrow stromal antigen 2; HM1.24 antigen;Tetherin;
P33076	C2TA_HUMAN	1130	91	CIITA ;	MHC class II transactivator ;
P07711	CATL1_HUMAN	333	850	MEP;	Procathepsin L ; Cathepsin L1 ;Major excreted protein;
O95992	CH25H_HUMAN	272	0	h25OH;	Cholesterol 25-hydroxylase ; Cholesterol 25-monooxygenase;
Q92499	DDX1_HUMAN	740	885	DBP-RB;	ATP-dependent RNA helicase DDX1; DEAD box protein 1;DEAD box protein retinoblastoma;
O95786	RIGI_HUMAN	925	213	RLR-1;RIG-1;RIG-I;	Antiviral innate immune response receptor RIG-I ; ATP-dependent RNA helicase DDX58 ;DEAD box protein 58;RIG-I-like receptor 1;RNA sensor RIG-I ;Retinoic acid-inducible gene 1 protein;Retinoic acid-inducible gene I protein;
Q96C10	DHX58_HUMAN	678	221	RLR-3;RLR;	ATP-dependent RNA helicase DHX58 ; ATP-dependent helicase LGP2 ;Protein D11Lgp2 homolog;RIG-I-like receptor 3;RIG-I-like receptor LGP2;
P68104	EF1A1_HUMAN	462	465	EF-1-alpha-1; EF-Tu;eEF1A-1;	Elongation factor 1-alpha 1; Elongation factor Tu;Eukaryotic elongation factor 1 A-1;Leukocyte receptor cluster member 7;
P49327	FAS_HUMAN	2511	1000		Fatty acid synthase; Type I fatty acid synthase;
P09958	FURIN_HUMAN	794	284	PACE;	Furin ; Dibasic-processing enzyme;Paired basic amino acid residue-cleaving enzyme;
Q9Y2I7	FYV1_HUMAN	2098	531	Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III;Type III PIP kinase;	1-phosphatidylinositol 3-phosphate 5-kinase ; FYVE finger-containing phosphoinositide kinase;PIKfyve;Phosphatidylinositol 3-phosphate 5-kinase type III;Serine-protein kinase PIKFYVE;
P04233	HG2A_HUMAN	296	35	Ii;	HLA class II histocompatibility antigen gamma chain ; HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;
Q16665	HIF1A_HUMAN	826	165	HIF-1-alpha ;HIF1-alpha ; bHLHe78;	Hypoxia-inducible factor 1-alpha ; ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1 ;Class E basic helix-loop-helix protein 78;Member of PAS protein 1 ;PAS domain-containing protein 8;
P04439	HLAA_HUMAN	365	1500	HLA-A;	HLA class I histocompatibility antigen, A alpha chain; Human leukocyte antigen A;
P01889	HLAB_HUMAN	362	1500	HLA-B;	HLA class I histocompatibility antigen, B alpha chain; Human leukocyte antigen B;
P13747	HLAE_HUMAN	358	1500		HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E;
P09429	HMGB1_HUMAN	215	83	HMG-1;	High mobility group protein B1; High mobility group protein 1;
Q96F46	I17RA_HUMAN	866	28	IL-17 receptor A;IL-17RA;	Interleukin-17 receptor A ; CDw217;
Q8NAC3	I17RC_HUMAN	791	6	IL-17 receptor C;IL-17RC; IL17Rhom;IL-17RL;	Interleukin-17 receptor C; Interleukin-17 receptor homolog;Interleukin-17 receptor-like protein;ZcytoR14;
Q9BYX4	IFIH1_HUMAN	1025	311	CADM-140 autoantigen;Helicard;MDA-5;RLR-2;	Interferon-induced helicase C domain-containing protein 1 ; Clinically amyopathic dermatomyositis autoantigen 140 kDa;Helicase with 2 CARD domains;Interferon-induced with helicase C domain protein 1;Melanoma differentiation-associated protein 5;Murabutide down-regulated protein;RIG-I-like receptor 2;RNA helicase-DEAD box protein 116;
P13164	IFM1_HUMAN	125	0	DSPA2a;	Interferon-induced transmembrane protein 1 ; Dispanin subfamily A member 2a;Interferon-induced protein 17;Interferon-inducible protein 9-27;Leu-13 antigen;
Q01629	IFM2_HUMAN	132	0	DSPA2c;	Interferon-induced transmembrane protein 2 ; Dispanin subfamily A member 2c;Interferon-inducible protein 1-8D;
Q01628	IFM3_HUMAN	133	0	DSPA2b;	Interferon-induced transmembrane protein 3 ; Dispanin subfamily A member 2b;Interferon-inducible protein 1-8U;
Q96PD4	IL17F_HUMAN	163	94	IL-17F;	Interleukin-17F; Cytokine ML-1;
Q16552	IL17_HUMAN	155	88	IL-17;IL-17A; CTLA-8;	Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8;
P08887	IL6RA_HUMAN	468	109	IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA; gp80;	Interleukin-6 receptor subunit alpha ; IL-6R 1;Membrane glycoprotein 80;
P40189	IL6RB_HUMAN	918	161	IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB; gp130 ;	Interleukin-6 receptor subunit beta ; CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;Oncostatin-M receptor subunit alpha;
P05231	IL6_HUMAN	212	24	IL-6; BSF-2;CDF;IFN-beta-2;	Interleukin-6 ; B-cell stimulatory factor 2;CTL differentiation factor;Hybridoma growth factor;Interferon beta-2;
P52292	IMA1_HUMAN	529	484		Importin subunit alpha-1 ; Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha;
P17181	INAR1_HUMAN	557	46	IFN-R-1;IFN-alpha/beta receptor 1; CRF2-1;	Interferon alpha/beta receptor 1; Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;Type I interferon receptor 1;
P48551	INAR2_HUMAN	515	12	IFN-R-2;IFN-alpha binding protein;IFN-alpha/beta receptor 2;	Interferon alpha/beta receptor 2; Interferon alpha binding protein;Type I interferon receptor 2;
Q14653	IRF3_HUMAN	427	97	IRF-3 ;	Interferon regulatory factor 3 {ECO:0000303|PubMed:9566918, ECO:0000303|PubMed:9803267};
Q13568	IRF5_HUMAN	498	99	IRF-5 ;	Interferon regulatory factor 5 ;
Q92985	IRF7_HUMAN	503	97	IRF-7;	Interferon regulatory factor 7;
P05161	ISG15_HUMAN	165	1500	IP17;hUCRP;	Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein;Interferon-induced 17 kDa protein;Ubiquitin cross-reactive protein;
P20701	ITAL_HUMAN	1170	392	LFA-1A;	Integrin alpha-L ; CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;Leukocyte function-associated molecule 1 alpha chain;
Q13241	KLRD1_HUMAN	179	592		Natural killer cells antigen CD94; KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;
Q16553	LY6E_HUMAN	131	0	Ly-6E; RIG-E;SCA-2;TSA-1;	Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein;Stem cell antigen 2;Thymic shared antigen 1;
Q7Z434	MAVS_HUMAN	540	46	MAVS ; Cardif ;IPS-1;VISA;	Mitochondrial antiviral-signaling protein ; CARD adapter inducing interferon beta ;Interferon beta promoter stimulator protein 1;Putative NF-kappa-B-activating protein 031N;Virus-induced-signaling adapter;
Q86U44	MTA70_HUMAN	580	149	hMETTL3 ;MT-A70;	N6-adenosine-methyltransferase catalytic subunit ; Methyltransferase-like protein 3 ;N6-adenosine-methyltransferase 70 kDa subunit;
Q99836	MYD88_HUMAN	296	61		Myeloid differentiation primary response protein MyD88 ;
Q9Y6K9	NEMO_HUMAN	419	45	NEMO ; IKKAP1;I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma;	NF-kappa-B essential modulator ; FIP-3;IkB kinase-associated protein 1;Inhibitor of nuclear factor kappa-B kinase subunit gamma;NF-kappa-B essential modifier;
P01185	NEU2_HUMAN	164	29		Vasopressin-neurophysin 2-copeptin; AVP-NPII;
Q16236	NF2L2_HUMAN	605	12	NF-E2-related factor 2 ;NFE2-related factor 2 ;Nrf-2 ;	Nuclear factor erythroid 2-related factor 2 ; HEBP1;Nuclear factor, erythroid derived 2, like 2 {ECO:0000303|PubMed:33009401, ECO:0000303|PubMed:7937919};
O14745	NHRF1_HUMAN	358	331	NHERF-1; EBP50;	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 ; Ezrin-radixin-moesin-binding phosphoprotein 50;Regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1;
P26715	NKG2A_HUMAN	233	421		NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A;NK cell receptor A;NKG2-A/B-activating NK receptor;
Q9C000	NLRP1_HUMAN	1473	272		NACHT, LRR and PYD domains-containing protein 1 ; Caspase recruitment domain-containing protein 7;Death effector filament-forming ced-4-like apoptosis protein ;Nucleotide-binding domain and caspase recruitment domain;
Q96P20	NLRP3_HUMAN	1036	197	CLR1.1 ;	NACHT, LRR and PYD domains-containing protein 3 ; Angiotensin/vasopressin receptor AII/AVP-like;Caterpiller protein 1.1 ;Cold-induced autoinflammatory syndrome 1 protein ;Cryopyrin ;PYRIN-containing APAF1-like protein 1 ;
O14786	NRP1_HUMAN	923	228		Neuropilin-1 ; Vascular endothelial cell growth factor 165 receptor;
P52948	NUP98_HUMAN	1817	224		Nuclear pore complex protein Nup98-Nup96 ;
P00973	OAS1_HUMAN	400	13	(2-5')oligo(A) synthase 1;2-5A synthase 1;	2'-5'-oligoadenylate synthase 1; E18/E16;p46/p42 OAS;
Q9H074	PAIP1_HUMAN	479	9	PABP-interacting protein 1;PAIP-1;Poly(A)-binding protein-interacting protein 1;	Polyadenylate-binding protein-interacting protein 1 ;
Q8N3R9	PALS1_HUMAN	675	199		Protein PALS1 ; MAGUK p55 subfamily member 5;Membrane protein, palmitoylated 5 ;Protein associated with Lin-7 1 {ECO:0000303|PubMed:12527193, ECO:0000312|HGNC:HGNC:18669};
P35232	PHB1_HUMAN	272	1		Prohibitin 1 ;
Q99623	PHB2_HUMAN	299	1		Prohibitin-2; B-cell receptor-associated protein BAP37;D-prohibitin;Repressor of estrogen receptor activity;
Q8NEB9	PK3C3_HUMAN	887	561	PI3-kinase type 3;PI3K type 3;PtdIns-3-kinase type 3;	Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase p100 subunit;Phosphoinositide-3-kinase class 3;hVps34;
P62937	PPIA_HUMAN	165	614	PPIase A;	Peptidyl-prolyl cis-trans isomerase A; Cyclophilin A;Cyclosporin A-binding protein;Rotamase A;
P51149	RAB7A_HUMAN	207	1500		Ras-related protein Rab-7a ;
P05109	S10A8_HUMAN	93	445	CFAG;MRP-8;p8;	Protein S100-A8 ; Calgranulin-A;Calprotectin L1L subunit;Cystic fibrosis antigen;Leukocyte L1 complex light chain;Migration inhibitory factor-related protein 8;S100 calcium-binding protein A8;Urinary stone protein band A;
O43765	SGTA_HUMAN	313	331	UBP;	Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT;Vpu-binding protein;
P84022	SMAD3_HUMAN	425	91	MAD homolog 3;Mad3;Mothers against DPP homolog 3;hMAD-3; SMAD 3;Smad3;hSMAD3;	Mothers against decapentaplegic homolog 3; JV15-2;SMAD family member 3;
O95721	SNP29_HUMAN	258	14	SNAP-29 ;	Synaptosomal-associated protein 29 ; Soluble 29 kDa NSF attachment protein ;Vesicle-membrane fusion protein SNAP-29;
P56962	STX17_HUMAN	302	9		Syntaxin-17 ;
Q9UHD2	TBK1_HUMAN	729	1500		Serine/threonine-protein kinase TBK1 ; NF-kappa-B-activating kinase ;T2K;TANK-binding kinase 1 ;
Q8IUC6	TCAM1_HUMAN	712	11	TICAM-1; MyD88-3;TIR domain-containing adapter protein inducing IFN-beta;	TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B;Putative NF-kappa-B-activating protein 502H;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;
O15455	TLR3_HUMAN	904	854		Toll-like receptor 3 ;
Q9NYK1	TLR7_HUMAN	1049	748		Toll-like receptor 7 ;
Q9NR97	TLR8_HUMAN	1041	635		Toll-like receptor 8 ;
Q5BJD5	TM41B_HUMAN	291	0		Transmembrane protein 41B ; Protein stasimon ;
O15393	TMPS2_HUMAN	492	1500		Transmembrane protease serine 2 ; Serine protease 10 ;
Q9NRS4	TMPS4_HUMAN	437	1500	CAPH2;MT-SP2;	Transmembrane protease serine 4 ; Channel-activating protease 2;Membrane-type serine protease 2;
O94826	TOM70_HUMAN	608	196		Mitochondrial import receptor subunit TOM70 ; Mitochondrial precursor proteins import receptor;Translocase of outer membrane 70 kDa subunit;Translocase of outer mitochondrial membrane protein 70 ;
Q8NHX9	TPC2_HUMAN	752	158		Two pore channel protein 2; Two pore calcium channel protein 2;
P29597	TYK2_HUMAN	1187	1500		Non-receptor tyrosine-protein kinase TYK2;
P47901	V1BR_HUMAN	424	663	V1bR;	Vasopressin V1b receptor ; AVPR V1b;AVPR V3;Antidiuretic hormone receptor 1b;Vasopressin V3 receptor;
Q9BV40	VAMP8_HUMAN	100	50	VAMP-8 ; EDB ;	Vesicle-associated membrane protein 8 ; Endobrevin ;
Q96JC1	VPS39_HUMAN	886	4	hVam6p;	Vam6/Vps39-like protein ; TRAP1-like protein;
P49754	VPS41_HUMAN	854	0		Vacuolar protein sorting-associated protein 41 homolog; S53;
Q5W0Z9	ZDH20_HUMAN	365	12	DHHC20 ;	Palmitoyltransferase ZDHHC20 ; Acyltransferase ZDHHC20 ;DHHC domain-containing cysteine-rich protein 20 ;Zinc finger DHHC domain-containing protein 20 ;
Q9ULC8	ZDHC8_HUMAN	765	12	DHHC-8 ;	Palmitoyltransferase ZDHHC8 ; Zinc finger DHHC domain-containing protein 8 ;Zinc finger protein 378;
Q9Y397	ZDHC9_HUMAN	364	12	DHHC-9;DHHC9;	Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9;Zinc finger protein 379;Zinc finger protein 380;

• SARS-CoV-2のアミノ酸配列は、NCBI Reference Sequence から取得しました。 ([NC_045512]Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome)

protein_id	length (amino acids)	Number of 3D homologues	product	gene	note
YP_009724389.1	7096	1500	2'-O-ribose methyltransferase	orf1ab	pp1ab; translated by -1 ribosomal frameshift
YP_009725297.1	180	29	leader protein		nsp1; produced by both pp1a and pp1ab
YP_009725298.1	638	8	nsp2		produced by both pp1a and pp1ab
YP_009725299.1	1945	1263	nsp3		former nsp1; conserved domains are: N-terminal
YP_009725300.1	500	9	nsp4		nsp4B_TM; contains transmembrane domain 2 (TM2);
YP_009725301.1	306	1500	3C-like proteinase		nsp5A_3CLpro and nsp5B_3CLpro; main proteinase
YP_009725302.1	290	0	nsp6		nsp6_TM; putative transmembrane domain; produced by
YP_009725303.1	83	95	nsp7		produced by both pp1a and pp1ab
YP_009725304.1	198	149	nsp8		produced by both pp1a and pp1ab
YP_009725305.1	113	66	nsp9		ssRNA-binding protein; produced by both pp1a and
YP_009725306.1	139	164	nsp10		nsp10_CysHis; formerly known as growth-factor-like
YP_009725307.1	932	68	RNA-dependent RNA polymerase		nsp12; NiRAN and RdRp; produced by pp1ab only
YP_009725308.1	601	170	helicase		nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding
YP_009725309.1	527	92	3'-to-5' exonuclease		nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab
YP_009725310.1	346	165	endoRNAse		nsp15-A1 and nsp15B-NendoU; produced by pp1ab only
YP_009725311.1	298	82	2'-O-ribose methyltransferase		nsp16_OMT; 2'-o-MT; produced by pp1ab only
YP_009725295.1	4405	1500	nsp11	orf1ab	pp1a
YP_009725312.1	13	0	nsp11		produced by pp1a only
YP_009724390.1	1273	1500	surface glycoprotein	S	structural protein; spike protein
YP_009724391.1	275	12	ORF3a protein	ORF3a
YP_009724392.1	75	18	envelope protein	E	ORF4; structural protein; E protein
YP_009724393.1	222	12	membrane glycoprotein	M	ORF5; structural protein
YP_009724394.1	61	0	ORF6 protein	ORF6
YP_009724395.1	121	4	ORF7a protein	ORF7a
YP_009725318.1	43	0	ORF7b	ORF7b
YP_009724396.1	121	9	ORF8 protein	ORF8
YP_009724397.2	419	256	nucleocapsid phosphoprotein	N	ORF9; structural protein
YP_009725255.1	38	0	ORF10 protein	ORF10

• COVID-19に対する薬剤研究やCOVID-19に対する薬剤転用研究で治療薬の候補とされている化合物のタンパク質との結合立体構造の情報を以下の表にまとめました。
• 各化合物についてHOMCOSの「化合物に対する結合蛋白質の検索」による解析結果を見ることができます。 その化合物自身および類似化合物とタンパク質の複合体の立体構造を表示します。

KEGG_ID	構造式	一般名	Number of identical compounds	Number of similar compounds (tanimoto=0.5)	商品名	効能
D01703		D01703 シクレソニド (JAN); Ciclesonide (JAN/USAN/INN)	0	10	オルベスコ (帝人ファーマ) 00059259	喘息治療薬, 抗炎症薬, グルココルチコイド受容体作動薬
D01425		D01425 ロピナビル (JAN); Lopinavir (JAN/USP/INN)	1	39		抗ウイルス薬, HIVプロテアーゼ阻害薬
D00427		D00427 リトナビル (JAN); Ritonavir (JAN/USP/INN)	1	31	ノービア (アッヴィ) 00059362	抗ウイルス薬, HIVプロテアーゼ阻害薬
D09537		D09537 ファビピラビル (JAN); Favipiravir (JAN/USAN/INN)	0	66	アビガン (富士フイルム富山化学) 00066852	抗ウイルス薬, RNAレプリカーゼ阻害薬
D09537_1		D09537_1 ファビピラビル・リボフラノシルリン酸体; Favipiravir-RMP; ファビピラビル活性体;	1	150		抗ウイルス薬, RNAレプリカーゼ阻害薬
D09537_2		D09537_2 ファビピラビル・リボフラノシル二リン酸体; Favipiravir-RDP; ファビピラビル活性体;	0	141		抗ウイルス薬, RNAレプリカーゼ阻害薬
D09537_3		D09537_3 ファビピラビル・リボフラノシル三リン酸体; Favipiravir-RTP; ファビピラビル活性体;	1	150		抗ウイルス薬, RNAレプリカーゼ阻害薬
D11472		D11472 レムデシビル (JAN); Remdesivir (JAN/USAN)	0	4	ベクルリー (ギリアド・サイエンシズ) 00069661	抗ウイルス薬, RNAポリメラーゼ阻害薬
D11472_1		D11472_1 レムデシビルリン酸体; Remdesivir-monophosphate (USAN	1	149		抗ウイルス薬
D11472_2		D11472_2 レムデシビル二リン酸体; Remdesivir-diphosphate (USAN	0	136		抗ウイルス薬
D11472_3		D11472_3 レムデシビル三リン酸体; Remdesivir-triphosphate (USAN	1	150		抗ウイルス薬
D02366		D02366 クロロキン; Chloroquine (USP/INN)	2	31		抗マラリア薬, 抗アメーバ薬
D08050		D08050 ヒドロキシクロロキン; Hydroxychloroquine (INN)	0	23		抗マラリア薬
D01670		D01670 ナファモスタットメシル酸塩 (JP18); Nafamostat mesylate (USAN); Nafamostat mesilate (JP18)	1	32	フサン (日医工) 00048710	抗凝固薬, 抗線溶薬, セリンプロテアーゼ阻害薬
D00429		D00429 サキナビル (JAN); Saquinavir (JAN/USP/INN)	1	10		抗ウイルス薬, HIVプロテアーゼ阻害薬
D01035		D01035 セファランチン (JAN); タマサキツヅラフジ抽出アルカロイド; Cepharanthine (JAN)	0	0	セファランチン (メディサ新薬) 00050591 セファランチン (メディサ新薬) 00060363	抗アレルギー薬, 血行促進薬
D00804		D00804 イベルメクチン (JAN); Ivermectin (JAN/USP/INN)	0	1	ストロメクトール (MSD) 00049234	抗寄生虫薬
D00292		D00292 デキサメタゾン (JP18); Dexamethasone (JP18/USP/INN)	1	111	アフタゾロン (あゆみ製薬) 00054356 デカドロン (日医工) 00054772 デカドロン (日医工) 00062800 レナデックス (ブリストル・マイヤーズスクイブ) 00069302	抗炎症薬, 鎮痒薬, グルココルチコイド受容体作動薬
D07486		D07486 アジスロマイシン; Azithromycin (INN)	1	25		抗生物質, タンパク質合成阻害薬
D08897		D08897 ダパグリフロジン; Dapagliflozin (USAN/INN)	1	39		糖尿病治療薬, SGLT-2阻害薬
D00570		D00570 コルヒチン (JP18); Colchicine (JP18/USP)	1	10	コルヒチン (高田製薬) 00058355	痛風治療薬, 白血球(好中球)遊走阻害薬, 微小管重合阻害薬
D07606		D07606 カモスタット; Camostat (INN)	0	13		抗炎症薬, セリンプロテアーゼ阻害薬
D10308		D10308 バリシチニブ (JAN); Baricitinib (JAN/USAN/INN)	1	9	オルミエント (日本イーライリリー) 00066989	抗炎症薬, 抗リウマチ薬, 免疫抑制薬, ヤヌスキナーゼ(JAK)阻害薬
D11943		D11943 モルヌピラビル (JAN); Molnupiravir (JAN/USAN)	1	112	ラゲブリオ (MSD) 00070173	抗ウイルス薬
D12244		D12244 ニルマトレルビル (JAN); PF-07321332; Nirmatrelvir (JAN/USAN); PF-07321332	3	58		抗ウイルス薬
D03506		D03506 塩酸シナンセリン; Cinanserin hydrochloride (USAN)	0	31		抗ウイルス薬

HOMCOSは、現在、文部科学省の創薬等支援技術基盤プラットフォーム事業の支援を受け、大阪大学 蛋白研 プロテインデータバンク研究室により開発・維持されています。

参考文献

• Kawabata T. (2016) HOMCOS: an update server to search and model complex 3D structures. J.Struct.Funct.Genomics. 17,83-99. [PubMed] [Publisher]
• Fukuhara N., Kawabata T. (2008) HOMCOS: a server to predict interacting protein pairs and interacting sites by homology modeling of complex structures. Nucleic Acids Res., 36, W185-W189. [PubMed]