新型コロナウィルスSARS-CoV-2に関連するタンパク質と化合物の立体構造

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PDBの更新日:20240207

UniProtのタンパク質(120)

  • SARS-CoV-2のアミノ酸配列は、UniProtのpre_releaseファイルから取得しました。これらの配列には、SARS-CoV-2 ウィルス (proteome UP000464024) 以外に、 SARS-CoV ウィルス (proteome UP000000354) 、および ヒトの標的タンパク質も含まれています。 ([HEAD_LINE] [FTP_SITE])
    AC ID length
    (amino acids)
    Number of
    3D homologues
    short name full name
    P0DTC3 AP3A_SARS2 275 12 ORF3a; ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
    P0DTC9 NCAP_SARS2 419 256 N; NC ;Protein N ; Nucleoprotein ; Nucleocapsid protein ;
    P0DTC6 NS6_SARS2 61 0 ORF6; ns6; ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
    P0DTC7 NS7A_SARS2 121 4 ORF7a; ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
    P0DTD8 NS7B_SARS2 43 0 ORF7b; ORF7b protein; Accessory protein 7b;
    P0DTC8 NS8_SARS2 121 9 ORF8; ns8; ORF8 protein; Non-structural protein 8;
    P0DTF1 ORF3B_SARS2 22 0 ORF3b; Putative ORF3b protein ;
    P0DTG1 ORF3C_SARS2 41 0 ORF3c; ORF3h; ORF3c protein ; ORF3h protein ;
    P0DTG0 ORF3D_SARS2 57 0 Putative ORF3d protein ;
    P0DTD2 ORF9B_SARS2 97 20 ORF9b; ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
    P0DTD3 ORF9C_SARS2 73 0 ORF9c; ORF14; Putative ORF9c protein ; Uncharacterized protein 14;
    P0DTD1 R1AB_SARS2 7096 1500 pp1ab; Replicase polyprotein 1ab; ORF1ab polyprotein;
    P0DTC1 R1A_SARS2 4405 1500 pp1a; Replicase polyprotein 1a; ORF1a polyprotein;
    P0DTC2 SPIKE_SARS2 1273 1500 S glycoprotein ; Spike glycoprotein ; E2 ;Peplomer protein ;
    P0DTC4 VEMP_SARS2 75 18 E;sM protein ; Envelope small membrane protein ;
    P0DTC5 VME1_SARS2 222 12 M; Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
    P59632 AP3A_SARS 274 12 ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
    P59595 NCAP_SARS 422 257 NC ;Protein N ; Nucleoprotein ; Nucleocapsid protein ;
    P59633 NS3B_SARS 154 0 ns3b; ORF3b protein; Accessory protein 3b;Non-structural protein 3b;Protein X2;
    P59634 NS6_SARS 63 0 ORF6; ns6; ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
    P59635 NS7A_SARS 122 4 ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
    Q7TFA1 NS7B_SARS 44 0 ns7b; Protein non-structural 7b; Accessory protein 7b;
    Q7TFA0 NS8A_SARS 39 0 ns8a; ORF8a protein; Accessory protein 8a;Protein non-structural 8a;
    Q80H93 NS8B_SARS 84 0 ns8b; ORF8b protein; Accessory protein 8b;Non-structural protein 8b;
    P59636 ORF9B_SARS 98 20 ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
    P0C6X7 R1AB_SARS 7073 1500 pp1ab; Replicase polyprotein 1ab; ORF1ab polyprotein;
    P0C6U8 R1A_SARS 4382 1500 pp1a; Replicase polyprotein 1a; ORF1a polyprotein;
    P59594 SPIKE_SARS 1255 1500 S glycoprotein ; Spike glycoprotein ; E2 ;Peplomer protein ;
    P59637 VEMP_SARS 76 18 E protein ;sM protein ; Envelope small membrane protein ;
    P59596 VME1_SARS 221 12 M protein ; Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
    Q7TLC7 Y14_SARS 70 0 Uncharacterized protein 14;
    Q9BYF1 ACE2_HUMAN 805 580 ACEH ;ACE-related carboxypeptidase; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog ;Angiotensin-converting enzyme-related carboxypeptidase ;Metalloprotease MPROT15 {ECO:0000303|Ref.6};
    P30556 AGTR1_HUMAN 359 929 AT1 receptor ; Type-1 angiotensin II receptor ; AT1AR ;AT1BR;Angiotensin II type-1 receptor ;
    Q4KMQ2 ANO6_HUMAN 910 107 SCAN channel; Anoctamin-6 ; Small-conductance calcium-activated nonselective cation channel;Transmembrane protein 16F;
    P02649 APOE_HUMAN 317 38 Apo-E; Apolipoprotein E ;
    Q9NVJ2 ARL8B_HUMAN 186 1500 ADP-ribosylation factor-like protein 8B ; ADP-ribosylation factor-like protein 10C;Novel small G protein indispensable for equal chromosome segregation 1;
    P17405 ASM_HUMAN 631 35 aSMase; Sphingomyelin phosphodiesterase ; Acid sphingomyelinase {ECO:0000303|PubMed:25339683, ECO:0000303|PubMed:27349982, ECO:0000303|PubMed:33163980};
    P35613 BASI_HUMAN 385 53 EMMPRIN;HAb18G ;TCSF; Basigin ; 5F7;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;Hepatoma-associated antigen ;Leukocyte activation antigen M6;OK blood group antigen;Tumor cell-derived collagenase stimulatory factor;
    O00327 BMAL1_HUMAN 626 164 bHLHe5; Basic helix-loop-helix ARNT-like protein 1 ; Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3;
    Q10589 BST2_HUMAN 180 47 BST-2; Bone marrow stromal antigen 2; HM1.24 antigen;Tetherin;
    P33076 C2TA_HUMAN 1130 75 CIITA ; MHC class II transactivator ;
    P07711 CATL1_HUMAN 333 847 MEP; Procathepsin L ; Cathepsin L1 ;Major excreted protein;
    O95992 CH25H_HUMAN 272 0 h25OH; Cholesterol 25-hydroxylase ; Cholesterol 25-monooxygenase;
    Q92499 DDX1_HUMAN 740 887 DBP-RB; ATP-dependent RNA helicase DDX1; DEAD box protein 1;DEAD box protein retinoblastoma;
    O95786 RIGI_HUMAN 925 211 RLR-1;RIG-1;RIG-I; Antiviral innate immune response receptor RIG-I ; ATP-dependent RNA helicase DDX58 ;DEAD box protein 58;RIG-I-like receptor 1;RNA sensor RIG-I ;Retinoic acid-inducible gene 1 protein;Retinoic acid-inducible gene I protein;
    Q96C10 DHX58_HUMAN 678 219 RLR-3;RLR; ATP-dependent RNA helicase DHX58 ; ATP-dependent helicase LGP2 ;Protein D11Lgp2 homolog;RIG-I-like receptor 3;RIG-I-like receptor LGP2;
    P68104 EF1A1_HUMAN 462 460 EF-1-alpha-1; EF-Tu;eEF1A-1; Elongation factor 1-alpha 1; Elongation factor Tu;Eukaryotic elongation factor 1 A-1;Leukocyte receptor cluster member 7;
    P49327 FAS_HUMAN 2511 984 Fatty acid synthase; Type I fatty acid synthase;
    P09958 FURIN_HUMAN 794 275 PACE; Furin ; Dibasic-processing enzyme;Paired basic amino acid residue-cleaving enzyme;
    Q9Y2I7 FYV1_HUMAN 2098 533 Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III;Type III PIP kinase; 1-phosphatidylinositol 3-phosphate 5-kinase ; FYVE finger-containing phosphoinositide kinase;PIKfyve;Phosphatidylinositol 3-phosphate 5-kinase type III;Serine-protein kinase PIKFYVE;
    P04233 HG2A_HUMAN 296 35 Ii; HLA class II histocompatibility antigen gamma chain ; HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;
    Q16665 HIF1A_HUMAN 826 163 HIF-1-alpha ;HIF1-alpha ; bHLHe78; Hypoxia-inducible factor 1-alpha ; ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1 ;Class E basic helix-loop-helix protein 78;Member of PAS protein 1 ;PAS domain-containing protein 8;
    P04439 HLAA_HUMAN 365 1500 HLA-A; HLA class I histocompatibility antigen, A alpha chain; Human leukocyte antigen A;
    P01889 HLAB_HUMAN 362 1500 HLA-B; HLA class I histocompatibility antigen, B alpha chain; Human leukocyte antigen B;
    P13747 HLAE_HUMAN 358 1500 HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E;
    P09429 HMGB1_HUMAN 215 82 HMG-1; High mobility group protein B1; High mobility group protein 1;
    Q96F46 I17RA_HUMAN 866 28 IL-17 receptor A;IL-17RA; Interleukin-17 receptor A ; CDw217;
    Q8NAC3 I17RC_HUMAN 791 6 IL-17 receptor C;IL-17RC; IL17Rhom;IL-17RL; Interleukin-17 receptor C; Interleukin-17 receptor homolog;Interleukin-17 receptor-like protein;ZcytoR14;
    Q9BYX4 IFIH1_HUMAN 1025 309 CADM-140 autoantigen;Helicard;MDA-5;RLR-2; Interferon-induced helicase C domain-containing protein 1 ; Clinically amyopathic dermatomyositis autoantigen 140 kDa;Helicase with 2 CARD domains;Interferon-induced with helicase C domain protein 1;Melanoma differentiation-associated protein 5;Murabutide down-regulated protein;RIG-I-like receptor 2;RNA helicase-DEAD box protein 116;
    P13164 IFM1_HUMAN 125 0 DSPA2a; Interferon-induced transmembrane protein 1 ; Dispanin subfamily A member 2a;Interferon-induced protein 17;Interferon-inducible protein 9-27;Leu-13 antigen;
    Q01629 IFM2_HUMAN 132 0 DSPA2c; Interferon-induced transmembrane protein 2 ; Dispanin subfamily A member 2c;Interferon-inducible protein 1-8D;
    Q01628 IFM3_HUMAN 133 0 DSPA2b; Interferon-induced transmembrane protein 3 ; Dispanin subfamily A member 2b;Interferon-inducible protein 1-8U;
    Q96PD4 IL17F_HUMAN 163 89 IL-17F; Interleukin-17F; Cytokine ML-1;
    Q16552 IL17_HUMAN 155 83 IL-17;IL-17A; CTLA-8; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8;
    P08887 IL6RA_HUMAN 468 95 IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA; gp80; Interleukin-6 receptor subunit alpha ; IL-6R 1;Membrane glycoprotein 80;
    P40189 IL6RB_HUMAN 918 151 IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB; gp130 ; Interleukin-6 receptor subunit beta ; CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;Oncostatin-M receptor subunit alpha;
    P05231 IL6_HUMAN 212 20 IL-6; BSF-2;CDF;IFN-beta-2; Interleukin-6 ; B-cell stimulatory factor 2;CTL differentiation factor;Hybridoma growth factor;Interferon beta-2;
    P52292 IMA1_HUMAN 529 478 Importin subunit alpha-1 ; Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha;
    P17181 INAR1_HUMAN 557 46 IFN-R-1;IFN-alpha/beta receptor 1; CRF2-1; Interferon alpha/beta receptor 1; Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;Type I interferon receptor 1;
    P48551 INAR2_HUMAN 515 12 IFN-R-2;IFN-alpha binding protein;IFN-alpha/beta receptor 2; Interferon alpha/beta receptor 2; Interferon alpha binding protein;Type I interferon receptor 2;
    Q14653 IRF3_HUMAN 427 97 IRF-3 ; Interferon regulatory factor 3 {ECO:0000303|PubMed:9566918, ECO:0000303|PubMed:9803267};
    Q13568 IRF5_HUMAN 498 99 IRF-5 ; Interferon regulatory factor 5 ;
    Q92985 IRF7_HUMAN 503 97 IRF-7; Interferon regulatory factor 7;
    P05161 ISG15_HUMAN 165 1500 IP17;hUCRP; Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein;Interferon-induced 17 kDa protein;Ubiquitin cross-reactive protein;
    P20701 ITAL_HUMAN 1170 389 LFA-1A; Integrin alpha-L ; CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;Leukocyte function-associated molecule 1 alpha chain;
    Q13241 KLRD1_HUMAN 179 585 Natural killer cells antigen CD94; KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;
    Q16553 LY6E_HUMAN 131 0 Ly-6E; RIG-E;SCA-2;TSA-1; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein;Stem cell antigen 2;Thymic shared antigen 1;
    Q7Z434 MAVS_HUMAN 540 46 MAVS ; Cardif ;IPS-1;VISA; Mitochondrial antiviral-signaling protein ; CARD adapter inducing interferon beta ;Interferon beta promoter stimulator protein 1;Putative NF-kappa-B-activating protein 031N;Virus-induced-signaling adapter;
    Q86U44 MTA70_HUMAN 580 149 hMETTL3 ;MT-A70; N6-adenosine-methyltransferase catalytic subunit ; Methyltransferase-like protein 3 ;N6-adenosine-methyltransferase 70 kDa subunit;
    Q99836 MYD88_HUMAN 296 61 Myeloid differentiation primary response protein MyD88 ;
    Q9Y6K9 NEMO_HUMAN 419 45 NEMO ; IKKAP1;I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma; NF-kappa-B essential modulator ; FIP-3;IkB kinase-associated protein 1;Inhibitor of nuclear factor kappa-B kinase subunit gamma;NF-kappa-B essential modifier;
    P01185 NEU2_HUMAN 164 29 Vasopressin-neurophysin 2-copeptin; AVP-NPII;
    Q16236 NF2L2_HUMAN 605 12 NF-E2-related factor 2 ;NFE2-related factor 2 ;Nrf-2 ; Nuclear factor erythroid 2-related factor 2 ; HEBP1;Nuclear factor, erythroid derived 2, like 2 {ECO:0000303|PubMed:33009401, ECO:0000303|PubMed:7937919};
    O14745 NHRF1_HUMAN 358 331 NHERF-1; EBP50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 ; Ezrin-radixin-moesin-binding phosphoprotein 50;Regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1;
    P26715 NKG2A_HUMAN 233 415 NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A;NK cell receptor A;NKG2-A/B-activating NK receptor;
    Q9C000 NLRP1_HUMAN 1473 256 NACHT, LRR and PYD domains-containing protein 1 ; Caspase recruitment domain-containing protein 7;Death effector filament-forming ced-4-like apoptosis protein ;Nucleotide-binding domain and caspase recruitment domain;
    Q96P20 NLRP3_HUMAN 1036 181 CLR1.1 ; NACHT, LRR and PYD domains-containing protein 3 ; Angiotensin/vasopressin receptor AII/AVP-like;Caterpiller protein 1.1 ;Cold-induced autoinflammatory syndrome 1 protein ;Cryopyrin ;PYRIN-containing APAF1-like protein 1 ;
    O14786 NRP1_HUMAN 923 228 Neuropilin-1 ; Vascular endothelial cell growth factor 165 receptor;
    P52948 NUP98_HUMAN 1817 209 Nuclear pore complex protein Nup98-Nup96 ;
    P00973 OAS1_HUMAN 400 13 (2-5')oligo(A) synthase 1;2-5A synthase 1; 2'-5'-oligoadenylate synthase 1; E18/E16;p46/p42 OAS;
    Q9H074 PAIP1_HUMAN 479 9 PABP-interacting protein 1;PAIP-1;Poly(A)-binding protein-interacting protein 1; Polyadenylate-binding protein-interacting protein 1 ;
    Q8N3R9 PALS1_HUMAN 675 199 Protein PALS1 ; MAGUK p55 subfamily member 5;Membrane protein, palmitoylated 5 ;Protein associated with Lin-7 1 {ECO:0000303|PubMed:12527193, ECO:0000312|HGNC:HGNC:18669};
    P35232 PHB1_HUMAN 272 1 Prohibitin 1 ;
    Q99623 PHB2_HUMAN 299 1 Prohibitin-2; B-cell receptor-associated protein BAP37;D-prohibitin;Repressor of estrogen receptor activity;
    Q8NEB9 PK3C3_HUMAN 887 543 PI3-kinase type 3;PI3K type 3;PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase p100 subunit;Phosphoinositide-3-kinase class 3;hVps34;
    P62937 PPIA_HUMAN 165 613 PPIase A; Peptidyl-prolyl cis-trans isomerase A; Cyclophilin A;Cyclosporin A-binding protein;Rotamase A;
    P51149 RAB7A_HUMAN 207 1500 Ras-related protein Rab-7a ;
    P05109 S10A8_HUMAN 93 445 CFAG;MRP-8;p8; Protein S100-A8 ; Calgranulin-A;Calprotectin L1L subunit;Cystic fibrosis antigen;Leukocyte L1 complex light chain;Migration inhibitory factor-related protein 8;S100 calcium-binding protein A8;Urinary stone protein band A;
    O43765 SGTA_HUMAN 313 303 UBP; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT;Vpu-binding protein;
    P84022 SMAD3_HUMAN 425 91 MAD homolog 3;Mad3;Mothers against DPP homolog 3;hMAD-3; SMAD 3;Smad3;hSMAD3; Mothers against decapentaplegic homolog 3; JV15-2;SMAD family member 3;
    O95721 SNP29_HUMAN 258 14 SNAP-29 ; Synaptosomal-associated protein 29 ; Soluble 29 kDa NSF attachment protein ;Vesicle-membrane fusion protein SNAP-29;
    P56962 STX17_HUMAN 302 9 Syntaxin-17 ;
    Q9UHD2 TBK1_HUMAN 729 1500 Serine/threonine-protein kinase TBK1 ; NF-kappa-B-activating kinase ;T2K;TANK-binding kinase 1 ;
    Q8IUC6 TCAM1_HUMAN 712 11 TICAM-1; MyD88-3;TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B;Putative NF-kappa-B-activating protein 502H;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;
    O15455 TLR3_HUMAN 904 838 Toll-like receptor 3 ;
    Q9NYK1 TLR7_HUMAN 1049 732 Toll-like receptor 7 ;
    Q9NR97 TLR8_HUMAN 1041 620 Toll-like receptor 8 ;
    Q5BJD5 TM41B_HUMAN 291 0 Transmembrane protein 41B ; Protein stasimon ;
    O15393 TMPS2_HUMAN 492 1500 Transmembrane protease serine 2 ; Serine protease 10 ;
    Q9NRS4 TMPS4_HUMAN 437 1500 CAPH2;MT-SP2; Transmembrane protease serine 4 ; Channel-activating protease 2;Membrane-type serine protease 2;
    O94826 TOM70_HUMAN 608 175 Mitochondrial import receptor subunit TOM70 ; Mitochondrial precursor proteins import receptor;Translocase of outer membrane 70 kDa subunit;Translocase of outer mitochondrial membrane protein 70 ;
    Q8NHX9 TPC2_HUMAN 752 152 Two pore channel protein 2; Two pore calcium channel protein 2;
    P29597 TYK2_HUMAN 1187 1500 Non-receptor tyrosine-protein kinase TYK2;
    P47901 V1BR_HUMAN 424 570 V1bR; Vasopressin V1b receptor ; AVPR V1b;AVPR V3;Antidiuretic hormone receptor 1b;Vasopressin V3 receptor;
    Q9BV40 VAMP8_HUMAN 100 50 VAMP-8 ; EDB ; Vesicle-associated membrane protein 8 ; Endobrevin ;
    Q96JC1 VPS39_HUMAN 886 4 hVam6p; Vam6/Vps39-like protein ; TRAP1-like protein;
    P49754 VPS41_HUMAN 854 0 Vacuolar protein sorting-associated protein 41 homolog; S53;
    Q5W0Z9 ZDH20_HUMAN 365 12 DHHC20 ; Palmitoyltransferase ZDHHC20 ; Acyltransferase ZDHHC20 ;DHHC domain-containing cysteine-rich protein 20 ;Zinc finger DHHC domain-containing protein 20 ;
    Q9ULC8 ZDHC8_HUMAN 765 12 DHHC-8 ; Palmitoyltransferase ZDHHC8 ; Zinc finger DHHC domain-containing protein 8 ;Zinc finger protein 378;
    Q9Y397 ZDHC9_HUMAN 364 12 DHHC-9;DHHC9; Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9;Zinc finger protein 379;Zinc finger protein 380;

    Genpeptのタンパク質(28)

    protein_id length
    (amino acids)
    Number of
    3D homologues
    product gene note
    YP_009724389.1 7096 1500 2'-O-ribose methyltransferase orf1ab pp1ab; translated by -1 ribosomal frameshift
    YP_009725297.1 180 29 leader protein nsp1; produced by both pp1a and pp1ab
    YP_009725298.1 638 8 nsp2 produced by both pp1a and pp1ab
    YP_009725299.1 1945 1239 nsp3 former nsp1; conserved domains are: N-terminal
    YP_009725300.1 500 9 nsp4 nsp4B_TM; contains transmembrane domain 2 (TM2);
    YP_009725301.1 306 1500 3C-like proteinase nsp5A_3CLpro and nsp5B_3CLpro; main proteinase
    YP_009725302.1 290 0 nsp6 nsp6_TM; putative transmembrane domain; produced by
    YP_009725303.1 83 93 nsp7 produced by both pp1a and pp1ab
    YP_009725304.1 198 145 nsp8 produced by both pp1a and pp1ab
    YP_009725305.1 113 64 nsp9 ssRNA-binding protein; produced by both pp1a and
    YP_009725306.1 139 148 nsp10 nsp10_CysHis; formerly known as growth-factor-like
    YP_009725307.1 932 66 RNA-dependent RNA polymerase nsp12; NiRAN and RdRp; produced by pp1ab only
    YP_009725308.1 601 166 helicase nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding
    YP_009725309.1 527 92 3'-to-5' exonuclease nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab
    YP_009725310.1 346 165 endoRNAse nsp15-A1 and nsp15B-NendoU; produced by pp1ab only
    YP_009725311.1 298 66 2'-O-ribose methyltransferase nsp16_OMT; 2'-o-MT; produced by pp1ab only
    YP_009725295.1 4405 1500 nsp11 orf1ab pp1a
    YP_009725312.1 13 0 nsp11 produced by pp1a only
    YP_009724390.1 1273 1500 surface glycoprotein S structural protein; spike protein
    YP_009724391.1 275 12 ORF3a protein ORF3a
    YP_009724392.1 75 18 envelope protein E ORF4; structural protein; E protein
    YP_009724393.1 222 12 membrane glycoprotein M ORF5; structural protein
    YP_009724394.1 61 0 ORF6 protein ORF6
    YP_009724395.1 121 4 ORF7a protein ORF7a
    YP_009725318.1 43 0 ORF7b ORF7b
    YP_009724396.1 121 9 ORF8 protein ORF8
    YP_009724397.2 419 256 nucleocapsid phosphoprotein N ORF9; structural protein
    YP_009725255.1 38 0 ORF10 protein ORF10

    報告された効果のある化合物(26)

    KEGG_ID 構造式 一般名 Number of
    identical compounds
    Number of
    similar compounds
    (tanimoto=0.5)
    商品名 効能
    D01703 D01703 シクレソニド (JAN); Ciclesonide (JAN/USAN/INN) 0 10 オルベスコ (帝人ファーマ) 00059259 喘息治療薬, 抗炎症薬, グルココルチコイド受容体作動薬
    D01425 D01425 ロピナビル (JAN); Lopinavir (JAN/USP/INN) 1 39 抗ウイルス薬, HIVプロテアーゼ阻害薬
    D00427 D00427 リトナビル (JAN); Ritonavir (JAN/USP/INN) 1 31 ノービア (アッヴィ) 00059362 抗ウイルス薬, HIVプロテアーゼ阻害薬
    D09537 D09537 ファビピラビル (JAN); Favipiravir (JAN/USAN/INN) 0 66 アビガン (富士フイルム富山化学) 00066852 抗ウイルス薬, RNAレプリカーゼ阻害薬
    D09537_1 D09537_1 ファビピラビル・リボフラノシルリン酸体; Favipiravir-RMP; ファビピラビル活性体; 1 150 抗ウイルス薬, RNAレプリカーゼ阻害薬
    D09537_2 D09537_2 ファビピラビル・リボフラノシル二リン酸体; Favipiravir-RDP; ファビピラビル活性体; 0 141 抗ウイルス薬, RNAレプリカーゼ阻害薬
    D09537_3 D09537_3 ファビピラビル・リボフラノシル三リン酸体; Favipiravir-RTP; ファビピラビル活性体; 1 150 抗ウイルス薬, RNAレプリカーゼ阻害薬
    D11472 D11472 レムデシビル (JAN); Remdesivir (JAN/USAN) 0 4 ベクルリー (ギリアド・サイエンシズ) 00069661 抗ウイルス薬, RNAポリメラーゼ阻害薬
    D11472_1 D11472_1 レムデシビルリン酸体; Remdesivir-monophosphate (USAN 1 149 抗ウイルス薬
    D11472_2 D11472_2 レムデシビル二リン酸体; Remdesivir-diphosphate (USAN 0 134 抗ウイルス薬
    D11472_3 D11472_3 レムデシビル三リン酸体; Remdesivir-triphosphate (USAN 1 150 抗ウイルス薬
    D02366 D02366 クロロキン; Chloroquine (USP/INN) 2 31 抗マラリア薬, 抗アメーバ薬
    D08050 D08050 ヒドロキシクロロキン; Hydroxychloroquine (INN) 0 23 抗マラリア薬
    D01670 D01670 ナファモスタットメシル酸塩 (JP18); Nafamostat mesylate (USAN); Nafamostat mesilate (JP18) 1 32 フサン (日医工) 00048710 抗凝固薬, 抗線溶薬, セリンプロテアーゼ阻害薬
    D00429 D00429 サキナビル (JAN); Saquinavir (JAN/USP/INN) 1 10 抗ウイルス薬, HIVプロテアーゼ阻害薬
    D01035 D01035 セファランチン (JAN); タマサキツヅラフジ抽出アルカロイド; Cepharanthine (JAN) 0 0 セファランチン (メディサ新薬) 00050591 セファランチン (メディサ新薬) 00060363 抗アレルギー薬, 血行促進薬
    D00804 D00804 イベルメクチン (JAN); Ivermectin (JAN/USP/INN) 0 1 ストロメクトール (MSD) 00049234 抗寄生虫薬
    D00292 D00292 デキサメタゾン (JP18); Dexamethasone (JP18/USP/INN) 1 111 アフタゾロン (あゆみ製薬) 00054356 デカドロン (日医工) 00054772 デカドロン (日医工) 00062800 レナデックス (ブリストル・マイヤーズスクイブ) 00069302 抗炎症薬, 鎮痒薬, グルココルチコイド受容体作動薬
    D07486 D07486 アジスロマイシン; Azithromycin (INN) 1 25 抗生物質, タンパク質合成阻害薬
    D08897 D08897 ダパグリフロジン; Dapagliflozin (USAN/INN) 1 39 糖尿病治療薬, SGLT-2阻害薬
    D00570 D00570 コルヒチン (JP18); Colchicine (JP18/USP) 1 10 コルヒチン (高田製薬) 00058355 痛風治療薬, 白血球(好中球)遊走阻害薬, 微小管重合阻害薬
    D07606 D07606 カモスタット; Camostat (INN) 0 13 抗炎症薬, セリンプロテアーゼ阻害薬
    D10308 D10308 バリシチニブ (JAN); Baricitinib (JAN/USAN/INN) 1 9 オルミエント (日本イーライリリー) 00066989 抗炎症薬, 抗リウマチ薬, 免疫抑制薬, ヤヌスキナーゼ(JAK)阻害薬
    D11943 D11943 モルヌピラビル (JAN); Molnupiravir (JAN/USAN) 0 112 ラゲブリオ (MSD) 00070173 抗ウイルス薬
    D12244 D12244 ニルマトレルビル (JAN); PF-07321332; Nirmatrelvir (JAN/USAN); PF-07321332 3 58 抗ウイルス薬
    D03506 D03506 塩酸シナンセリン; Cinanserin hydrochloride (USAN) 0 31 抗ウイルス薬


    タンパク質の配列類似性検索にはBLASTを、化合物の構造類似性検索にはKCOMBUを用いています。

    HOMCOSは、現在、文部科学省の創薬等支援技術基盤プラットフォーム事業の支援を受け、大阪大学 蛋白研 プロテインデータバンク研究室により開発・維持されています。

    参考文献

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    Last Update:2022/01/19