HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID	QueryLength	Homolgous Sequence in PDB	UniProt Query	TITLE
873230	212	20	P05231(IL6_HUMAN)	RecName: Full=Interleukin-6 ; Short=IL-6;AltName: Full=B-cell stimulatory factor 2; Short=BSF-2;AltName: Full=CTL differentiation factor; Short=CDF;AltName: Full=Hybridoma growth factor;AltName: Full=Interferon beta-2; Short=IFN-beta-2;Flags: Precursor;
QUERYSEQ	MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVL IQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P05231(IL6_HUMAN)]

212
	region	name	description
	1-29	SIGNAL	ECO:0000269\|PubMed:2610854, ECO:0000269\|PubMed:3279116"
	30-212	CHAIN	/note="Interleukin-6" /id="PRO_0000015582"
	1-43	DISORDER	predicted by DISOPRED

MONOMER

212

pdb_id a¹ identity[%]² description

4cni C 100.0 IL6_HUMAN INTERLEUKIN-6

2l3y A 40.7 IL6_MOUSE Interleukin-6

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

212 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1i1r[2] A IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN[301 aa] B 0.0
/26.5 10
/11 Q98823_HHV8 VIRAL IL-6

1i1r[2] A IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN[301 aa] B 26.3
/26.5 19
/19 Q98823_HHV8 VIRAL IL-6

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] B 100.0
/100.0 12
/12 IL6_HUMAN Interleukin-6

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] B 100.0
/100.0 14
/14 IL6_HUMAN Interleukin-6

1p9m[2] C IL6RA_HUMAN Interleukin-6 receptor alpha chain[201 aa] B 100.0
/100.0 13
/13 IL6_HUMAN Interleukin-6

5fuc[2] D D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. A 100.0
/99.3 14
/14 IL6_HUMAN INTERLEUKIN-6

4cni[2] E OLOKIZUMAB HEAVY CHAIN, FAB PORTION[219 aa] C 100.0
/100.0 13
/13 IL6_HUMAN INTERLEUKIN-6

4cni[2] F OLOKIZUMAB LIGHT CHAIN, FAB PORTION[214 aa] C 100.0
/100.0 6
/6 IL6_HUMAN INTERLEUKIN-6

4j4l[2] A A4L9V2_LISMN Q4G1L3_EPTBU Internalin B,REPEAT MODULES,Variable lymphocyte re.. C 100.0
/99.4 18
/19 IL6_HUMAN Interleukin-6

4o9h[1] B Heavy Chain of the Camelid Fab fragment 61H7[200 a.. A 100.0
/100.0 10
/10 IL6_HUMAN Interleukin-6

4o9h[1] C Light Chain of the Camelid Fab fragment 61H7[211 a.. A 100.0
/100.0 7
/7 IL6_HUMAN Interleukin-6

4zs7[1] B Llama Fab fragment 68F2 heavy chain[222 aa] A 100.0
/100.0 13
/13 IL6_HUMAN Interleukin-6

4zs7[1] C Llama Fab fragment 68F2 light chain[210 aa] A 100.0
/100.0 11
/11 IL6_HUMAN Interleukin-6

5fuc[1] E VHH6[110 aa] B 100.0
/100.0 7
/7 IL6_HUMAN INTERLEUKIN-6

8d82[2] A IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha[296 a.. B 100.0
/100.0 14
/14 IL6_HUMAN Interleukin-6

8d82[2] C IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] B 100.0
/100.0 13
/13 IL6_HUMAN Interleukin-6

8d82[2] F IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] B 100.0
/100.0 13
/13 IL6_HUMAN Interleukin-6

5fuc[1] F VHH6[124 aa] A 90.0
/99.3 10
/11 IL6_HUMAN INTERLEUKIN-6

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

NUCLEOTIDE

212 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4ni7[1] B SOMAmer SL1025 A 100.0
/100.0 19
/19 IL6_HUMAN Interleukin-6

4ni9[2] A SOMAmer SL1025 B 100.0
/100.0 22
/22 IL6_HUMAN Interleukin-6

4ni9[2] D SOMAmer SL1025 B 100.0
/100.0 5
/5 IL6_HUMAN Interleukin-6

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

212 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1alu[2] A IL6_HUMAN INTERLEUKIN-6[157 aa] A 100.0
/100.0 22
/22 IL6_HUMAN INTERLEUKIN-6

1alu[2] A IL6_HUMAN INTERLEUKIN-6[157 aa] A 100.0
/100.0 11
/11 IL6_HUMAN INTERLEUKIN-6

4ni9[2] C IL6_HUMAN Interleukin-6[148 aa] B 100.0
/100.0 3
/3 IL6_HUMAN Interleukin-6

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

212 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1alu[8] B SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 IL6_HUMAN INTERLEUKIN-6

1alu[2] B SO4
SULFATE ION[5 atoms] A 100.0
/100.0 2
/2 IL6_HUMAN INTERLEUKIN-6

1alu[5] D SO4
SULFATE ION[5 atoms] A 100.0
/100.0 2
/2 IL6_HUMAN INTERLEUKIN-6

1alu[3] E SO4
SULFATE ION[5 atoms] A 100.0
/100.0 5
/5 IL6_HUMAN INTERLEUKIN-6

4cni[2] I SO4
SULFATE ION[5 atoms] C 100.0
/100.0 3
/3 IL6_HUMAN INTERLEUKIN-6

1alu[5] F TLA
L(+)-TARTARIC ACID[10 atoms] A 100.0
/100.0 4
/4 IL6_HUMAN INTERLEUKIN-6

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
212
	pdb_id	a¹	identity[%]²	description
	4cni	C	100.0	IL6_HUMAN INTERLEUKIN-6
	2l3y	A	40.7	IL6_MOUSE Interleukin-6
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO
212	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1i1r[2]	A	IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN[301 aa]	B	0.0 /26.5	10 /11	Q98823_HHV8 VIRAL IL-6
	1i1r[2]	A	IL6RB_HUMAN INTERLEUKIN-6 RECEPTOR BETA CHAIN[301 aa]	B	26.3 /26.5	19 /19	Q98823_HHV8 VIRAL IL-6
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	B	100.0 /100.0	12 /12	IL6_HUMAN Interleukin-6
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	B	100.0 /100.0	14 /14	IL6_HUMAN Interleukin-6
	1p9m[2]	C	IL6RA_HUMAN Interleukin-6 receptor alpha chain[201 aa]	B	100.0 /100.0	13 /13	IL6_HUMAN Interleukin-6
	5fuc[2]	D	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..	A	100.0 /99.3	14 /14	IL6_HUMAN INTERLEUKIN-6
	4cni[2]	E	OLOKIZUMAB HEAVY CHAIN, FAB PORTION[219 aa]	C	100.0 /100.0	13 /13	IL6_HUMAN INTERLEUKIN-6
	4cni[2]	F	OLOKIZUMAB LIGHT CHAIN, FAB PORTION[214 aa]	C	100.0 /100.0	6 /6	IL6_HUMAN INTERLEUKIN-6
	4j4l[2]	A	A4L9V2_LISMN Q4G1L3_EPTBU Internalin B,REPEAT MODULES,Variable lymphocyte re..	C	100.0 /99.4	18 /19	IL6_HUMAN Interleukin-6
	4o9h[1]	B	Heavy Chain of the Camelid Fab fragment 61H7[200 a..	A	100.0 /100.0	10 /10	IL6_HUMAN Interleukin-6
	4o9h[1]	C	Light Chain of the Camelid Fab fragment 61H7[211 a..	A	100.0 /100.0	7 /7	IL6_HUMAN Interleukin-6
	4zs7[1]	B	Llama Fab fragment 68F2 heavy chain[222 aa]	A	100.0 /100.0	13 /13	IL6_HUMAN Interleukin-6
	4zs7[1]	C	Llama Fab fragment 68F2 light chain[210 aa]	A	100.0 /100.0	11 /11	IL6_HUMAN Interleukin-6
	5fuc[1]	E	VHH6[110 aa]	B	100.0 /100.0	7 /7	IL6_HUMAN INTERLEUKIN-6
	8d82[2]	A	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha[296 a..	B	100.0 /100.0	14 /14	IL6_HUMAN Interleukin-6
	8d82[2]	C	IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa]	B	100.0 /100.0	13 /13	IL6_HUMAN Interleukin-6
	8d82[2]	F	IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa]	B	100.0 /100.0	13 /13	IL6_HUMAN Interleukin-6
	5fuc[1]	F	VHH6[124 aa]	A	90.0 /99.3	10 /11	IL6_HUMAN INTERLEUKIN-6
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
NUCLEOTIDE
212	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	4ni7[1]	B	SOMAmer SL1025	A	100.0 /100.0	19 /19	IL6_HUMAN Interleukin-6
	4ni9[2]	A	SOMAmer SL1025	B	100.0 /100.0	22 /22	IL6_HUMAN Interleukin-6
	4ni9[2]	D	SOMAmer SL1025	B	100.0 /100.0	5 /5	IL6_HUMAN Interleukin-6
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
212	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1alu[2]	A	IL6_HUMAN INTERLEUKIN-6[157 aa]	A	100.0 /100.0	22 /22	IL6_HUMAN INTERLEUKIN-6
	1alu[2]	A	IL6_HUMAN INTERLEUKIN-6[157 aa]	A	100.0 /100.0	11 /11	IL6_HUMAN INTERLEUKIN-6
	4ni9[2]	C	IL6_HUMAN Interleukin-6[148 aa]	B	100.0 /100.0	3 /3	IL6_HUMAN Interleukin-6
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
212	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1alu[8]	B	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	3 /3	IL6_HUMAN INTERLEUKIN-6
	1alu[2]	B	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	2 /2	IL6_HUMAN INTERLEUKIN-6
	1alu[5]	D	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	2 /2	IL6_HUMAN INTERLEUKIN-6
	1alu[3]	E	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	5 /5	IL6_HUMAN INTERLEUKIN-6
	4cni[2]	I	SO4 SULFATE ION[5 atoms]	C	100.0 /100.0	3 /3	IL6_HUMAN INTERLEUKIN-6
	1alu[5]	F	TLA L(+)-TARTARIC ACID[10 atoms]	A	100.0 /100.0	4 /4	IL6_HUMAN INTERLEUKIN-6
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

Contact Molecules for Homologous Proteins

Summary Bars[0.0 %]

UniProt Feature Tables [P05231(IL6_HUMAN)]