ID   ORF9C_SARS2             Reviewed;          73 AA.
AC   P0DTD3;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=Putative ORF9c protein {ECO:0000305|PubMed:32854725};
DE            Short=ORF9c;
DE   AltName: Full=Uncharacterized protein 14;
DE            Short=ORF14;
GN   ORFNames=9c;
OS   Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus;
OC   Severe acute respiratory syndrome coronavirus.
OX   NCBI_TaxID=2697049;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RX   PubMed=32015508; DOI=10.1038/s41586-020-2008-3;
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A new coronavirus associated with human respiratory disease in China.";
RL   Nature 579:265-269(2020).
RN   [2]
RX   PubMed=32854725; DOI=10.1186/s12985-020-01402-1;
RA   Michel C.J., Mayer C., Poch O., Thompson J.D.;
RT   "Characterization of accessory genes in coronavirus genomes.";
RL   Virol. J. 17:131-131(2020).
RN   [3]
RX   PubMed=33976134; DOI=10.1038/s41467-021-22905-7;
RA   Jungreis I., Sealfon R., Kellis M.;
RT   "SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44
RT   Sarbecovirus genomes.";
RL   Nat. Commun. 12:2642-2642(2021).
RN   [4]
RX   PubMed=35180394; DOI=10.1016/j.stemcr.2022.01.014;
RA   Liu J., Zhang Y., Han L., Guo S., Wu S., Doud E.H., Wang C., Chen H.,
RA   Rubart-von der Lohe M., Wan J., Yang L.;
RT   "Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral
RT   gene Orf9c on human pluripotent stem cell-derived cardiomyocytes.";
RL   Stem Cell Reports 17:522-537(2022).
CC   -!- FUNCTION: May induce apoptosis in cardiomyocytes when overexpressed ex-
CC       vivo. {ECO:0000269|PubMed:35180394}.
CC       P0DTD3; Q9H3K2: GHITM; Xeno; NbExp=3; IntAct=EBI-25475917, EBI-2868909;
CC       P0DTD3; Q86VR2: RETREG3; Xeno; NbExp=3; IntAct=EBI-25475917, EBI-10192441;
CC       P0DTD3; O43765: SGTA; Xeno; NbExp=3; IntAct=EBI-25475917, EBI-347996;
CC       P0DTD3; Q9UMX0: UBQLN1; Xeno; NbExp=3; IntAct=EBI-25475917, EBI-741480;
CC       P0DTD3; Q9UHD9: UBQLN2; Xeno; NbExp=4; IntAct=EBI-25475917, EBI-947187;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- CAUTION: Product of a dubious CDS prediction.
CC       {ECO:0000303|PubMed:33976134}.
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DR   EMBL; MN908947; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   BioGRID; 4383954; 513.
DR   IntAct; P0DTD3; 126.
DR   MINT; P0DTD3; -.
DR   AGR; RefSeq:P0DTD3; -.
DR   PRO; PR:P0DTD3; -.
DR   Proteomes; UP000464024; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035113; Protein_14_SARS-like.
DR   Pfam; PF17635; bCoV_Orf14; 1.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..73
FT                   /note="Putative ORF9c protein"
FT                   /id="PRO_0000449658"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         49
FT                   /note="V -> L (in strain: Gamma)"
FT                   /evidence="ECO:0000305"
FT   VARIANT         50
FT                   /note="G -> N (in strain: Alpha/B.1.1.7, Gamma/P.1,
FT                   Omicron/BA.1, Omicron/BA.2, Omicron/BA.2.12.2, Omicron/
FT                   BA.4, Omicron BA.5)"
FT                   /evidence="ECO:0000305"
FT   VARIANT         50
FT                   /note="G -> W (in strain: Delta/B.1.617.2)"
FT                   /evidence="ECO:0000305"
FT   VARIANT         52
FT                   /note="L -> F (in strain: Beta/B.1.351)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   73 AA;  8050 MW;  8CCDEF1C0EA37D06 CRC64;