Contact Molecules for Homologous Proteins
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PID	QueryLength	Homolgous Sequence in PDB	UniProt Query	TITLE
878282	296	35	P04233(HG2A_HUMAN)	RecName: Full=HLA class II histocompatibility antigen gamma chain ;AltName: Full=HLA-DR antigens-associated invariant chain;AltName: Full=Ia antigen-associated invariant chain; Short=Ii;AltName: CD_antigen=CD74;Contains: RecName: Full=Class-II-associated invariant chain peptide ; Short=CLIP ;
QUERYSEQ	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

UniProt Feature Tables [P04233(HG2A_HUMAN)]

296
	region	name	description
	1-296	CHAIN	/note="HLA class II histocompatibility antigen gamma chain" /id="PRO_0000067954"
	97-120	PEPTIDE	/note="Class-II-associated invariant chain peptide" /id="PRO_0000448886"
	1-46	TOPO_DOM	/note="Cytoplasmic"
	47-72	TRANSMEM	/note="Helical; Signal-anchor for type II membrane protein"
	73-296	TOPO_DOM	/note="Extracellular"
	210-271	DOMAIN	/note="Thyroglobulin type-1"
	1-40	REGION	/note="Disordered"
	225-226	REGION	/note="Required for interaction with CTSL" ECO:0000305|PubMed:32855215"
	263-296	REGION	/note="Disordered"
	1-296	DISORDER	predicted by DISOPRED

MONOMER
296
	pdb_id	a1	identity[%]2	description
	1iie	A	100.0	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN)
	1icf	F	100.0	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	7n4y	B	38.8	A0A4W2CHS8_BOBOX Thyroglobulin
	1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.

HETERO
296	pdb_id	contact mol		homologue
		a3	description	a4	identity[%]5	Ncon6	description
	1icf[3]	A	CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa]	E	100.0 /100.0	22 /22	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[1]	C	CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa]	E	100.0 /100.0	1 /1	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[3]	B	CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa]	E	100.0 /100.0	5 /5	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[1]	D	CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa]	E	100.0 /100.0	8 /8	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
296	pdb_id	contact mol		homologue
		a3	description	a4	identity[%]5	Ncon6	description
	1icf[3]	G	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	E	100.0 /100.0	2 /2	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
296	pdb_id	contact mol		homologue
		a3	description	a4	identity[%]5	Ncon6	description
	1zt5[1]	B	FE2 FE (II) ION[1 atoms]	A	0.0 /47.7	2 /2	IBP1_HUMAN Insulin-like growth factor binding protein 1
	3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
296	pdb_id	contact mol		homologue
		a3	description	a4	identity[%]5	Ncon6	description
	1iie[6]	B	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI..	A	100.0 /100.0	23 /23	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI..
	7qtq[1]	B	THYG_BOVIN Thyroglobulin[1789 aa]	A	25.0 /40.3	4 /133	THYG_BOVIN Thyroglobulin
	7qtq[1]	A	THYG_BOVIN Thyroglobulin[1790 aa]	B	25.0 /40.3	4 /133	THYG_BOVIN Thyroglobulin
	7n4y[2]	B	A0A4W2CHS8_BOBOX Thyroglobulin[2455 aa]	A	16.7 /38.8	6 /165	A0A4W2CHS8_BOBOX Thyroglobulin
	3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
296	pdb_id	contact mol		homologue
		a3	description	a4	identity[%]5	Ncon6	description
	8d6t[2]	D	CAC CACODYLATE ION[5 atoms]	A	100.0 /40.8	1 /2	SAX_LITCT Saxiphilin
	8d6t[2]	E	CAC CACODYLATE ION[5 atoms]	A	0.0 /40.8	1 /5	SAX_LITCT Saxiphilin
	8d6t[1]	F	CAC CACODYLATE ION[5 atoms]	A	0.0 /40.8	1 /1	SAX_LITCT Saxiphilin
	3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.