HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID	QueryLength	Homolgous Sequence in PDB	UniProt Query	TITLE
1223534	296	41	P04233(HG2A_HUMAN)	RecName: Full=HLA class II histocompatibility antigen gamma chain ;AltName: Full=HLA-DR antigens-associated invariant chain;AltName: Full=Ia antigen-associated invariant chain; Short=Ii;AltName: CD_antigen=CD74;Contains: RecName: Full=Class-II-associated invariant chain peptide ; Short=CLIP ;
QUERYSEQ	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P04233(HG2A_HUMAN)]

296
	region	name	description
	1-296	CHAIN	/note="HLA class II histocompatibility antigen gamma chain" /id="PRO_0000067954"
	97-120	PEPTIDE	/note="Class-II-associated invariant chain peptide" /id="PRO_0000448886"
	1-46	TOPO_DOM	/note="Cytoplasmic"
	47-72	TRANSMEM	/note="Helical; Signal-anchor for type II membrane protein"
	73-296	TOPO_DOM	/note="Extracellular"
	210-271	DOMAIN	/note="Thyroglobulin type-1"
	1-40	REGION	/note="Disordered"
	225-226	REGION	/note="Required for interaction with CTSL" ECO:0000305\|PubMed:32855215"
	263-296	REGION	/note="Disordered"
	1-296	DISORDER	predicted by DISOPRED

MONOMER

296

pdb_id a¹ identity[%]² description

1iie A 100.0 HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN)

1icf E 100.0 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

8vsp I 100.0 HG2A_HUMAN HLA class II histocompatibility antigen gamma chain

7n4y B 38.8 A0A4W2CHS8_BOBOX Thyroglobulin

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

296 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1icf[3] A CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa] E 100.0
/100.0 22
/22 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

1icf[1] C CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa] E 100.0
/100.0 1
/1 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

1icf[3] B CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa] E 100.0
/100.0 5
/5 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

1icf[1] D CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa] E 100.0
/100.0 8
/8 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

8vrw[3] A DRA_HUMAN HLA class II histocompatibility antigen, DR alpha .. C 100.0
/100.0 15
/15 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vrw[3] D DRA_HUMAN HLA class II histocompatibility antigen, DR alpha .. C 100.0
/100.0 10
/10 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vrw[3] B DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta.. C 100.0
/100.0 12
/12 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vsp[3] A DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha .. C 100.0
/100.0 14
/14 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vsp[3] D DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha .. C 100.0
/100.0 11
/11 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vsp[3] G DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha .. C 100.0
/100.0 1
/1 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

8vsp[3] B DQB1_HUMAN HLA class II histocompatibility antigen, DQ beta 1.. C 100.0
/100.0 12
/12 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

296 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1icf[3] G NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. E 100.0
/100.0 2
/2 HG2A_HUMAN PROTEIN (INVARIANT CHAIN)

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

METAL

296 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1zt5[1] B FE2
FE (II) ION[1 atoms] A 0.0
/47.7 2
/2 IBP1_HUMAN Insulin-like growth factor binding protein 1

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

296 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1iie[6] B HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI.. A 100.0
/100.0 23
/23 HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI..

8vrw[12] F HG2A_HUMAN HLA class II histocompatibility antigen gamma chai.. C 100.0
/100.0 10
/10 HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..

7qtq[1] B THYG_BOVIN Thyroglobulin[1789 aa] A 25.0
/40.3 4
/133 THYG_BOVIN Thyroglobulin

7qtq[1] A THYG_BOVIN Thyroglobulin[1790 aa] B 25.0
/40.3 4
/133 THYG_BOVIN Thyroglobulin

7n4y[2] B A0A4W2CHS8_BOBOX Thyroglobulin[2455 aa] A 16.7
/38.8 6
/165 A0A4W2CHS8_BOBOX Thyroglobulin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

296 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

8d6t[2] D CAC
CACODYLATE ION[5 atoms] A 100.0
/40.8 1
/2 SAX_LITCT Saxiphilin

8d6t[2] E CAC
CACODYLATE ION[5 atoms] A 0.0
/40.8 1
/5 SAX_LITCT Saxiphilin

8d6t[1] F CAC
CACODYLATE ION[5 atoms] A 0.0
/40.8 1
/1 SAX_LITCT Saxiphilin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
296
	pdb_id	a¹	identity[%]²	description
	1iie	A	100.0	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN)
	1icf	E	100.0	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	8vsp	I	100.0	HG2A_HUMAN HLA class II histocompatibility antigen gamma chain
	7n4y	B	38.8	A0A4W2CHS8_BOBOX Thyroglobulin
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO
296	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1icf[3]	A	CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa]	E	100.0 /100.0	22 /22	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[1]	C	CATL_HUMAN PROTEIN (CATHEPSIN L: HEAVY CHAIN)[175 aa]	E	100.0 /100.0	1 /1	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[3]	B	CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa]	E	100.0 /100.0	5 /5	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	1icf[1]	D	CATL_HUMAN PROTEIN (CATHEPSIN L: LIGHT CHAIN)[42 aa]	E	100.0 /100.0	8 /8	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	8vrw[3]	A	DRA_HUMAN HLA class II histocompatibility antigen, DR alpha ..	C	100.0 /100.0	15 /15	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vrw[3]	D	DRA_HUMAN HLA class II histocompatibility antigen, DR alpha ..	C	100.0 /100.0	10 /10	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vrw[3]	B	DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta..	C	100.0 /100.0	12 /12	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vsp[3]	A	DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha ..	C	100.0 /100.0	14 /14	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vsp[3]	D	DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha ..	C	100.0 /100.0	11 /11	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vsp[3]	G	DQA1_HUMAN HLA class II histocompatibility antigen, DQ alpha ..	C	100.0 /100.0	1 /1	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	8vsp[3]	B	DQB1_HUMAN HLA class II histocompatibility antigen, DQ beta 1..	C	100.0 /100.0	12 /12	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
296	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1icf[3]	G	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	E	100.0 /100.0	2 /2	HG2A_HUMAN PROTEIN (INVARIANT CHAIN)
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
296	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1zt5[1]	B	FE2 FE (II) ION[1 atoms]	A	0.0 /47.7	2 /2	IBP1_HUMAN Insulin-like growth factor binding protein 1
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
296	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1iie[6]	B	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI..	A	100.0 /100.0	23 /23	HG2A_HUMAN PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAI..
	8vrw[12]	F	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..	C	100.0 /100.0	10 /10	HG2A_HUMAN HLA class II histocompatibility antigen gamma chai..
	7qtq[1]	B	THYG_BOVIN Thyroglobulin[1789 aa]	A	25.0 /40.3	4 /133	THYG_BOVIN Thyroglobulin
	7qtq[1]	A	THYG_BOVIN Thyroglobulin[1790 aa]	B	25.0 /40.3	4 /133	THYG_BOVIN Thyroglobulin
	7n4y[2]	B	A0A4W2CHS8_BOBOX Thyroglobulin[2455 aa]	A	16.7 /38.8	6 /165	A0A4W2CHS8_BOBOX Thyroglobulin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
296	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	8d6t[2]	D	CAC CACODYLATE ION[5 atoms]	A	100.0 /40.8	1 /2	SAX_LITCT Saxiphilin
	8d6t[2]	E	CAC CACODYLATE ION[5 atoms]	A	0.0 /40.8	1 /5	SAX_LITCT Saxiphilin
	8d6t[1]	F	CAC CACODYLATE ION[5 atoms]	A	0.0 /40.8	1 /1	SAX_LITCT Saxiphilin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

Contact Molecules for Homologous Proteins

Summary Bars[0.0 %]

UniProt Feature Tables [P04233(HG2A_HUMAN)]