ID   NS6_SARS2               Reviewed;          61 AA.
AC   P0DTC6;
DT   22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-APR-2020, sequence version 1.
DT   02-DEC-2020, entry version 5.
DE   RecName: Full=ORF6 protein;
DE            Short=ORF6;
DE   AltName: Full=Accessory protein 6;
DE   AltName: Full=Non-structural protein 6;
DE            Short=ns6;
DE   AltName: Full=Protein X3;
GN   ORFNames=6;
OS   Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Sarbecovirus.
OX   NCBI_TaxID=2697049;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RX   PubMed=32015508; DOI=10.1038/s41586-020-2008-3;
RA   Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W.,
RA   Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y.,
RA   Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.;
RT   "A new coronavirus associated with human respiratory disease in China.";
RL   Nature 579:265-269(2020).
CC   -!- FUNCTION: Disrupts cell nuclear import complex formation by tethering
CC       karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention
CC       of import factors at the ER/Golgi membrane leads to a loss of transport
CC       into the nucleus. Thereby prevents STAT1 nuclear translocation in
CC       response to interferon signaling, thus blocking the expression of
CC       interferon stimulated genes (ISGs) that display multiple antiviral
CC       activities. {ECO:0000250|UniProtKB:P59634}.
CC   -!- SUBUNIT: Interacts with host KPNA2. May interact with nsp8. Interacts
CC       with protein ORF9b. {ECO:0000250|UniProtKB:P59634}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P59634}. Host Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:P59634}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P59634}. Note=Localizes to virus-induced
CC       vesicular structures called double membrane vesicles.
CC       {ECO:0000250|UniProtKB:P59634}.
CC   -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family.
CC       {ECO:0000305}.
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DR   EMBL; MN908947; QHD43420.1; -; Genomic_RNA.
DR   RefSeq; YP_009724394.1; NC_045512.2.
DR   BioGRID; 4383870; 23.
DR   IntAct; P0DTC6; 21.
DR   GeneID; 43740572; -.
DR   Proteomes; UP000464024; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR022736; NS6_bCoV.
DR   Pfam; PF12133; bCoV_NS6; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host endoplasmic reticulum; Host Golgi apparatus;
KW   Host membrane; Membrane; Reference proteome; Virulence.
FT   CHAIN           1..61
FT                   /note="ORF6 protein"
FT                   /id="PRO_0000449653"
SQ   SEQUENCE   61 AA;  7273 MW;  B21BD303F59A1D0A CRC64;