ID NS6_SARS2 Reviewed; 61 AA. AC P0DTC6; DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot. DT 22-APR-2020, sequence version 1. DT 02-DEC-2020, entry version 5. DE RecName: Full=ORF6 protein; DE Short=ORF6; DE AltName: Full=Accessory protein 6; DE AltName: Full=Non-structural protein 6; DE Short=ns6; DE AltName: Full=Protein X3; GN ORFNames=6; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Sarbecovirus. OX NCBI_TaxID=2697049; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=32015508; DOI=10.1038/s41586-020-2008-3; RA Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., RA Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., RA Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.; RT "A new coronavirus associated with human respiratory disease in China."; RL Nature 579:265-269(2020). CC -!- FUNCTION: Disrupts cell nuclear import complex formation by tethering CC karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention CC of import factors at the ER/Golgi membrane leads to a loss of transport CC into the nucleus. Thereby prevents STAT1 nuclear translocation in CC response to interferon signaling, thus blocking the expression of CC interferon stimulated genes (ISGs) that display multiple antiviral CC activities. {ECO:0000250|UniProtKB:P59634}. CC -!- SUBUNIT: Interacts with host KPNA2. May interact with nsp8. Interacts CC with protein ORF9b. {ECO:0000250|UniProtKB:P59634}. CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:P59634}. Host Golgi apparatus membrane CC {ECO:0000250|UniProtKB:P59634}. Host cytoplasm CC {ECO:0000250|UniProtKB:P59634}. Note=Localizes to virus-induced CC vesicular structures called double membrane vesicles. CC {ECO:0000250|UniProtKB:P59634}. CC -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN908947; QHD43420.1; -; Genomic_RNA. DR RefSeq; YP_009724394.1; NC_045512.2. DR BioGRID; 4383870; 23. DR IntAct; P0DTC6; 21. DR GeneID; 43740572; -. DR Proteomes; UP000464024; Genome. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR InterPro; IPR022736; NS6_bCoV. DR Pfam; PF12133; bCoV_NS6; 1. PE 3: Inferred from homology; KW Host cytoplasm; Host endoplasmic reticulum; Host Golgi apparatus; KW Host membrane; Membrane; Reference proteome; Virulence. FT CHAIN 1..61 FT /note="ORF6 protein" FT /id="PRO_0000449653" SQ SEQUENCE 61 AA; 7273 MW; B21BD303F59A1D0A CRC64; MFHLVDFQVT IAEILLIIMR TFKVSIWNLD YIINLIIKNL SKSLTENKYS QLDEEQPMEI D //