ID VME1_SARS2 Reviewed; 222 AA. AC P0DTC5; DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot. DT 22-APR-2020, sequence version 1. DT 02-DEC-2020, entry version 5. DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04202}; DE Short=M; DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; GN ORFNames=M; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Sarbecovirus. OX NCBI_TaxID=2697049; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=32015508; DOI=10.1038/s41586-020-2008-3; RA Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., RA Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., RA Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.; RT "A new coronavirus associated with human respiratory disease in China."; RL Nature 579:265-269(2020). CC -!- FUNCTION: Component of the viral envelope that plays a central role in CC virus morphogenesis and assembly via its interactions with other viral CC proteins. {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE- CC ProRule:PRU01275}. CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding CC compartment of the host cell, which is located between endoplasmic CC reticulum and the Golgi complex. Forms a complex with HE and S CC proteins. Interacts with nucleocapsid N protein. This interaction CC probably participates in RNA packaging into the virus (By similarity). CC Interacts with the accessory proteins 3a and 7a (By similarity). CC {ECO:0000250|UniProtKB:P59596, ECO:0000255|HAMAP-Rule:MF_04202}. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP- CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04202}. Host Golgi apparatus membrane {ECO:0000255|HAMAP- CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04202}. Note=Largely embedded in the lipid bilayer. CC {ECO:0000255|HAMAP-Rule:MF_04202}. CC -!- SIMILARITY: Belongs to the betacoronaviruses M protein family. CC {ECO:0000255|HAMAP-Rule:MF_04202}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN908947; QHD43419.1; -; Genomic_RNA. DR RefSeq; YP_009724393.1; NC_045512.2. DR BioGRID; 4383846; 217. DR IntAct; P0DTC5; 216. DR ABCD; P0DTC5; 10 sequenced antibodies. DR GeneID; 43740571; -. DR Proteomes; UP000464024; Genome. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW. DR GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW. DR HAMAP; MF_04202; BETA_CORONA_M; 1. DR InterPro; IPR002574; M_CoV. DR Pfam; PF01635; CoV_M; 1. DR PROSITE; PS51927; COV_M; 1. PE 3: Inferred from homology; KW Glycoprotein; Host Golgi apparatus; Host membrane; Host-virus interaction; KW Membrane; Reference proteome; Transmembrane; Transmembrane helix; KW Viral envelope protein; Viral immunoevasion; Viral matrix protein; Virion. FT CHAIN 1..222 FT /note="Membrane protein" FT /id="PRO_0000449652" FT TOPO_DOM 2..19 FT /note="Virion surface" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 20..40 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 41..50 FT /note="Intravirion" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 51..71 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 72..79 FT /note="Virion surface" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 80..100 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 101..222 FT /note="Intravirion" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" SQ SEQUENCE 222 AA; 25147 MW; ED44D84C3BB9A6DB CRC64; MADSNGTITV EELKKLLEQW NLVIGFLFLT WICLLQFAYA NRNRFLYIIK LIFLWLLWPV TLACFVLAAV YRINWITGGI AIAMACLVGL MWLSYFIASF RLFARTRSMW SFNPETNILL NVPLHGTILT RPLLESELVI GAVILRGHLR IAGHHLGRCD IKDLPKEITV ATSRTLSYYK LGASQRVAGD SGFAAYSRYR IGNYKLNTDH SSSSDNIALL VQ //