ID V1BR_HUMAN Reviewed; 424 AA.
AC P47901; B0M0J6; Q5TZ00;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 02-OCT-2024, entry version 191.
DE RecName: Full=Vasopressin V1b receptor {ECO:0000305};
DE Short=V1bR;
DE AltName: Full=AVPR V1b;
DE AltName: Full=AVPR V3;
DE AltName: Full=Antidiuretic hormone receptor 1b;
DE AltName: Full=Vasopressin V3 receptor;
GN Name=AVPR1B {ECO:0000312|HGNC:HGNC:896}; Synonyms=AVPR3, VPR3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=7929452; DOI=10.1016/s0021-9258(18)47129-3;
RA Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S.,
RA Kawashima H.;
RT "Molecular cloning and functional expression of a cDNA encoding the human
RT V1b vasopressin receptor.";
RL J. Biol. Chem. 269:27088-27092(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=7805841; DOI=10.1016/0014-5793(94)01268-7;
RA de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X.,
RA Clauser E.;
RT "Cloning and characterization of the human V3 pituitary vasopressin
RT receptor.";
RL FEBS Lett. 356:215-220(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung carcinoma;
RX PubMed=9357056; DOI=10.1016/s0196-9781(97)00072-7;
RA North W.G., Fay M.J., Longo K.A., Du J.;
RT "Functional vasopressin V1 type receptors are present in variant as well as
RT classical forms of small-cell carcinoma.";
RL Peptides 18:985-993(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9581826;
RA North W.G., Fay M.J., Longo K.A., Du J.;
RT "Expression of all known vasopressin receptor subtypes by small cell tumors
RT implies a multifaceted role for this neuropeptide.";
RL Cancer Res. 58:1866-1871(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10607899; DOI=10.1016/s0378-1119(99)00468-0;
RA Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.;
RT "Nucleotide sequence and structural organization of the human vasopressin
RT pituitary receptor (V3) gene.";
RL Gene 241:57-64(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Kaighin V.A., Martin A.L., Aronstam R.S.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-65; ARG-191; GLY-267
RP AND HIS-364.
RG SeattleSNPs variation discovery resource;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [9]
RP FUNCTION, INTERACTION WITH SARS-COV-2 SPIKE GLYCOPROTEIN (MICROBIAL
RP FUNCTION), AND SUBCELLULAR LOCATION.
RX PubMed=33713620; DOI=10.1016/j.cell.2021.02.053;
RA Yeung M.L., Teng J.L.L., Jia L., Zhang C., Huang C., Cai J.P., Zhou R.,
RA Chan K.H., Zhao H., Zhu L., Siu K.L., Fung S.Y., Yung S., Chan T.M.,
RA To K.K., Chan J.F., Cai Z., Lau S.K.P., Chen Z., Jin D.Y., Woo P.C.Y.,
RA Yuen K.Y.;
RT "Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with
RT proteins related to the renin-angiotensin system.";
RL Cell 0:0-0(2021).
RN [10]
RP VARIANTS ASN-65 AND HIS-364.
RX PubMed=17909131; DOI=10.1001/archpsyc.64.10.1189;
RA Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J.,
RA Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.;
RT "Evidence of an association between the vasopressin V1b receptor gene
RT (AVPR1B) and childhood-onset mood disorders.";
RL Arch. Gen. Psychiatry 64:1189-1195(2007).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate a phosphatidyl-
CC inositol-calcium second messenger system.
CC -!- FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2
CC infection, may recognize and internalize the complex formed by AVP/Arg-
CC vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through
CC DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33713620};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; D31833; BAA06621.1; -; mRNA.
DR EMBL; L37112; AAA65687.1; -; mRNA.
DR EMBL; AF030512; AAB84293.1; -; mRNA.
DR EMBL; AF101726; AAD17892.1; -; mRNA.
DR EMBL; AF152238; AAF33681.1; -; Genomic_DNA.
DR EMBL; EU432111; ABY87910.1; -; mRNA.
DR EMBL; DQ194816; ABA03171.1; -; Genomic_DNA.
DR EMBL; BX571818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73015.1; -.
DR PIR; A55089; A55089.
DR RefSeq; NP_000698.1; NM_000707.3.
DR AlphaFoldDB; P47901; -.
DR SMR; P47901; -.
DR BioGRID; 107034; 31.
DR IntAct; P47901; 27.
DR STRING; 9606.ENSP00000356094; -.
DR BindingDB; P47901; -.
DR ChEMBL; CHEMBL1921; -.
DR DrugBank; DB09059; Atosiban.
DR DrugBank; DB00035; Desmopressin.
DR DrugBank; DB14642; Lypressin.
DR DrugBank; DB05452; PH-284.
DR DrugBank; DB05455; SR 121463.
DR DrugBank; DB02638; Terlipressin.
DR DrugBank; DB00067; Vasopressin.
DR DrugCentral; P47901; -.
DR GuidetoPHARMACOLOGY; 367; -.
DR TCDB; 9.A.14.10.2; the g-protein-coupled receptor (gpcr) family.
DR GlyCosmos; P47901; 1 site, No reported glycans.
DR GlyGen; P47901; 1 site.
DR iPTMnet; P47901; -.
DR PhosphoSitePlus; P47901; -.
DR BioMuta; AVPR1B; -.
DR DMDM; 1351392; -.
DR MassIVE; P47901; -.
DR PaxDb; 9606-ENSP00000356094; -.
DR PeptideAtlas; P47901; -.
DR Antibodypedia; 20687; 412 antibodies from 36 providers.
DR DNASU; 553; -.
DR Ensembl; ENST00000367126.5; ENSP00000356094.4; ENSG00000198049.7.
DR GeneID; 553; -.
DR KEGG; hsa:553; -.
DR MANE-Select; ENST00000367126.5; ENSP00000356094.4; NM_000707.5; NP_000698.1.
DR UCSC; uc001hds.3; human.
DR AGR; HGNC:896; -.
DR CTD; 553; -.
DR DisGeNET; 553; -.
DR GeneCards; AVPR1B; -.
DR HGNC; HGNC:896; AVPR1B.
DR HPA; ENSG00000198049; Tissue enriched (pituitary).
DR MIM; 600264; gene.
DR neXtProt; NX_P47901; -.
DR OpenTargets; ENSG00000198049; -.
DR PharmGKB; PA25188; -.
DR VEuPathDB; HostDB:ENSG00000198049; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P47901; -.
DR OMA; FNSHLWP; -.
DR OrthoDB; 2879183at2759; -.
DR PhylomeDB; P47901; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; P47901; -.
DR Reactome; R-HSA-388479; Vasopressin-like receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-5619099; Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI).
DR SignaLink; P47901; -.
DR SIGNOR; P47901; -.
DR BioGRID-ORCS; 553; 13 hits in 1155 CRISPR screens.
DR GeneWiki; Arginine_vasopressin_receptor_1B; -.
DR GenomeRNAi; 553; -.
DR Pharos; P47901; Tclin.
DR PRO; PR:P47901; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P47901; protein.
DR Bgee; ENSG00000198049; Expressed in adenohypophysis and 43 other cell types or tissues.
DR GO; GO:0005768; C:endosome; TAS:ProtInc.
DR GO; GO:0005794; C:Golgi apparatus; IDA:ARUK-UCL.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005080; F:protein kinase C binding; TAS:ProtInc.
DR GO; GO:0005000; F:vasopressin receptor activity; IDA:ARUK-UCL.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:ARUK-UCL.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:ARUK-UCL.
DR GO; GO:0090238; P:positive regulation of arachidonic acid secretion; IDA:ARUK-UCL.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:ARUK-UCL.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:ARUK-UCL.
DR GO; GO:0032430; P:positive regulation of phospholipase A2 activity; IDA:ARUK-UCL.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IDA:ARUK-UCL.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0046718; P:symbiont entry into host cell; IDA:UniProtKB.
DR GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR CDD; cd15386; 7tmA_V1bR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR015076; V1R_C.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000628; Vprs_rcpt_V1B.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24241:SF18; VASOPRESSIN V1B RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00897; VASOPRSNV1BR.
DR SMART; SM01164; DUF1856; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Proteomics identification; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..424
FT /note="Vasopressin V1b receptor"
FT /id="PRO_0000070203"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..303
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..424
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 107..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 65
FT /note="K -> N (in dbSNP:rs35369693)"
FT /evidence="ECO:0000269|PubMed:17909131, ECO:0000269|Ref.7"
FT /id="VAR_025159"
FT VARIANT 191
FT /note="G -> R (in dbSNP:rs33990840)"
FT /evidence="ECO:0000269|Ref.7"
FT /id="VAR_025160"
FT VARIANT 224
FT /note="H -> Q (in dbSNP:rs3891058)"
FT /id="VAR_061228"
FT VARIANT 267
FT /note="S -> G (in dbSNP:rs36030374)"
FT /evidence="ECO:0000269|Ref.7"
FT /id="VAR_025161"
FT VARIANT 364
FT /note="R -> H (in dbSNP:rs28632197)"
FT /evidence="ECO:0000269|PubMed:17909131, ECO:0000269|Ref.7"
FT /id="VAR_025162"
SQ SEQUENCE 424 AA; 46971 MW; 35190281D3EDB6A7 CRC64;
MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG
QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA
STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG
SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG
GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ
PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE
TIIF
//