3D structures of proteins and compounds related to Coronavirus SARS-CoV-2

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Date for updating PDB:20240207

Proteins in UniProt(120)

  • Amino acid sequences of SARS-CoV-2 were taken from UniProt pre_release files. They include entries for the SARS-CoV-2 virus (proteome UP000464024) and SARS-CoV virus (proteome UP000000354) and human target proteins. ([HEAD_LINE] [FTP_SITE])
    AC ID length
    (amino acids)
    Number of
    3D homologues
    short name full name
    P0DTC3 AP3A_SARS2 275 12 ORF3a; ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
    P0DTC9 NCAP_SARS2 419 256 N; NC ;Protein N ; Nucleoprotein ; Nucleocapsid protein ;
    P0DTC6 NS6_SARS2 61 0 ORF6; ns6; ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
    P0DTC7 NS7A_SARS2 121 4 ORF7a; ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
    P0DTD8 NS7B_SARS2 43 0 ORF7b; ORF7b protein; Accessory protein 7b;
    P0DTC8 NS8_SARS2 121 9 ORF8; ns8; ORF8 protein; Non-structural protein 8;
    P0DTF1 ORF3B_SARS2 22 0 ORF3b; Putative ORF3b protein ;
    P0DTG1 ORF3C_SARS2 41 0 ORF3c; ORF3h; ORF3c protein ; ORF3h protein ;
    P0DTG0 ORF3D_SARS2 57 0 Putative ORF3d protein ;
    P0DTD2 ORF9B_SARS2 97 20 ORF9b; ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
    P0DTD3 ORF9C_SARS2 73 0 ORF9c; ORF14; Putative ORF9c protein ; Uncharacterized protein 14;
    P0DTD1 R1AB_SARS2 7096 1500 pp1ab; Replicase polyprotein 1ab; ORF1ab polyprotein;
    P0DTC1 R1A_SARS2 4405 1500 pp1a; Replicase polyprotein 1a; ORF1a polyprotein;
    P0DTC2 SPIKE_SARS2 1273 1500 S glycoprotein ; Spike glycoprotein ; E2 ;Peplomer protein ;
    P0DTC4 VEMP_SARS2 75 18 E;sM protein ; Envelope small membrane protein ;
    P0DTC5 VME1_SARS2 222 12 M; Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
    P59632 AP3A_SARS 274 12 ORF3a protein; Accessory protein 3a;Protein 3a;Protein U274;Protein X1;
    P59595 NCAP_SARS 422 257 NC ;Protein N ; Nucleoprotein ; Nucleocapsid protein ;
    P59633 NS3B_SARS 154 0 ns3b; ORF3b protein; Accessory protein 3b;Non-structural protein 3b;Protein X2;
    P59634 NS6_SARS 63 0 ORF6; ns6; ORF6 protein; Accessory protein 6;Non-structural protein 6;Protein X3;
    P59635 NS7A_SARS 122 4 ORF7a protein; Accessory protein 7a;Protein U122;Protein X4;
    Q7TFA1 NS7B_SARS 44 0 ns7b; Protein non-structural 7b; Accessory protein 7b;
    Q7TFA0 NS8A_SARS 39 0 ns8a; ORF8a protein; Accessory protein 8a;Protein non-structural 8a;
    Q80H93 NS8B_SARS 84 0 ns8b; ORF8b protein; Accessory protein 8b;Non-structural protein 8b;
    P59636 ORF9B_SARS 98 20 ORF9b protein; Accessory protein 9b;ORF-9b;Protein 9b;
    P0C6X7 R1AB_SARS 7073 1500 pp1ab; Replicase polyprotein 1ab; ORF1ab polyprotein;
    P0C6U8 R1A_SARS 4382 1500 pp1a; Replicase polyprotein 1a; ORF1a polyprotein;
    P59594 SPIKE_SARS 1255 1500 S glycoprotein ; Spike glycoprotein ; E2 ;Peplomer protein ;
    P59637 VEMP_SARS 76 18 E protein ;sM protein ; Envelope small membrane protein ;
    P59596 VME1_SARS 221 12 M protein ; Membrane protein ; E1 glycoprotein ;Matrix glycoprotein ;Membrane glycoprotein ;
    Q7TLC7 Y14_SARS 70 0 Uncharacterized protein 14;
    Q9BYF1 ACE2_HUMAN 805 580 ACEH ;ACE-related carboxypeptidase; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog ;Angiotensin-converting enzyme-related carboxypeptidase ;Metalloprotease MPROT15 {ECO:0000303|Ref.6};
    P30556 AGTR1_HUMAN 359 929 AT1 receptor ; Type-1 angiotensin II receptor ; AT1AR ;AT1BR;Angiotensin II type-1 receptor ;
    Q4KMQ2 ANO6_HUMAN 910 107 SCAN channel; Anoctamin-6 ; Small-conductance calcium-activated nonselective cation channel;Transmembrane protein 16F;
    P02649 APOE_HUMAN 317 38 Apo-E; Apolipoprotein E ;
    Q9NVJ2 ARL8B_HUMAN 186 1500 ADP-ribosylation factor-like protein 8B ; ADP-ribosylation factor-like protein 10C;Novel small G protein indispensable for equal chromosome segregation 1;
    P17405 ASM_HUMAN 631 35 aSMase; Sphingomyelin phosphodiesterase ; Acid sphingomyelinase {ECO:0000303|PubMed:25339683, ECO:0000303|PubMed:27349982, ECO:0000303|PubMed:33163980};
    P35613 BASI_HUMAN 385 53 EMMPRIN;HAb18G ;TCSF; Basigin ; 5F7;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;Hepatoma-associated antigen ;Leukocyte activation antigen M6;OK blood group antigen;Tumor cell-derived collagenase stimulatory factor;
    O00327 BMAL1_HUMAN 626 164 bHLHe5; Basic helix-loop-helix ARNT-like protein 1 ; Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3;
    Q10589 BST2_HUMAN 180 47 BST-2; Bone marrow stromal antigen 2; HM1.24 antigen;Tetherin;
    P33076 C2TA_HUMAN 1130 75 CIITA ; MHC class II transactivator ;
    P07711 CATL1_HUMAN 333 847 MEP; Procathepsin L ; Cathepsin L1 ;Major excreted protein;
    O95992 CH25H_HUMAN 272 0 h25OH; Cholesterol 25-hydroxylase ; Cholesterol 25-monooxygenase;
    Q92499 DDX1_HUMAN 740 887 DBP-RB; ATP-dependent RNA helicase DDX1; DEAD box protein 1;DEAD box protein retinoblastoma;
    O95786 RIGI_HUMAN 925 211 RLR-1;RIG-1;RIG-I; Antiviral innate immune response receptor RIG-I ; ATP-dependent RNA helicase DDX58 ;DEAD box protein 58;RIG-I-like receptor 1;RNA sensor RIG-I ;Retinoic acid-inducible gene 1 protein;Retinoic acid-inducible gene I protein;
    Q96C10 DHX58_HUMAN 678 219 RLR-3;RLR; ATP-dependent RNA helicase DHX58 ; ATP-dependent helicase LGP2 ;Protein D11Lgp2 homolog;RIG-I-like receptor 3;RIG-I-like receptor LGP2;
    P68104 EF1A1_HUMAN 462 460 EF-1-alpha-1; EF-Tu;eEF1A-1; Elongation factor 1-alpha 1; Elongation factor Tu;Eukaryotic elongation factor 1 A-1;Leukocyte receptor cluster member 7;
    P49327 FAS_HUMAN 2511 984 Fatty acid synthase; Type I fatty acid synthase;
    P09958 FURIN_HUMAN 794 275 PACE; Furin ; Dibasic-processing enzyme;Paired basic amino acid residue-cleaving enzyme;
    Q9Y2I7 FYV1_HUMAN 2098 533 Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III;Type III PIP kinase; 1-phosphatidylinositol 3-phosphate 5-kinase ; FYVE finger-containing phosphoinositide kinase;PIKfyve;Phosphatidylinositol 3-phosphate 5-kinase type III;Serine-protein kinase PIKFYVE;
    P04233 HG2A_HUMAN 296 35 Ii; HLA class II histocompatibility antigen gamma chain ; HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;
    Q16665 HIF1A_HUMAN 826 163 HIF-1-alpha ;HIF1-alpha ; bHLHe78; Hypoxia-inducible factor 1-alpha ; ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1 ;Class E basic helix-loop-helix protein 78;Member of PAS protein 1 ;PAS domain-containing protein 8;
    P04439 HLAA_HUMAN 365 1500 HLA-A; HLA class I histocompatibility antigen, A alpha chain; Human leukocyte antigen A;
    P01889 HLAB_HUMAN 362 1500 HLA-B; HLA class I histocompatibility antigen, B alpha chain; Human leukocyte antigen B;
    P13747 HLAE_HUMAN 358 1500 HLA class I histocompatibility antigen, alpha chain E; MHC class I antigen E;
    P09429 HMGB1_HUMAN 215 82 HMG-1; High mobility group protein B1; High mobility group protein 1;
    Q96F46 I17RA_HUMAN 866 28 IL-17 receptor A;IL-17RA; Interleukin-17 receptor A ; CDw217;
    Q8NAC3 I17RC_HUMAN 791 6 IL-17 receptor C;IL-17RC; IL17Rhom;IL-17RL; Interleukin-17 receptor C; Interleukin-17 receptor homolog;Interleukin-17 receptor-like protein;ZcytoR14;
    Q9BYX4 IFIH1_HUMAN 1025 309 CADM-140 autoantigen;Helicard;MDA-5;RLR-2; Interferon-induced helicase C domain-containing protein 1 ; Clinically amyopathic dermatomyositis autoantigen 140 kDa;Helicase with 2 CARD domains;Interferon-induced with helicase C domain protein 1;Melanoma differentiation-associated protein 5;Murabutide down-regulated protein;RIG-I-like receptor 2;RNA helicase-DEAD box protein 116;
    P13164 IFM1_HUMAN 125 0 DSPA2a; Interferon-induced transmembrane protein 1 ; Dispanin subfamily A member 2a;Interferon-induced protein 17;Interferon-inducible protein 9-27;Leu-13 antigen;
    Q01629 IFM2_HUMAN 132 0 DSPA2c; Interferon-induced transmembrane protein 2 ; Dispanin subfamily A member 2c;Interferon-inducible protein 1-8D;
    Q01628 IFM3_HUMAN 133 0 DSPA2b; Interferon-induced transmembrane protein 3 ; Dispanin subfamily A member 2b;Interferon-inducible protein 1-8U;
    Q96PD4 IL17F_HUMAN 163 89 IL-17F; Interleukin-17F; Cytokine ML-1;
    Q16552 IL17_HUMAN 155 83 IL-17;IL-17A; CTLA-8; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8;
    P08887 IL6RA_HUMAN 468 95 IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA; gp80; Interleukin-6 receptor subunit alpha ; IL-6R 1;Membrane glycoprotein 80;
    P40189 IL6RB_HUMAN 918 151 IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB; gp130 ; Interleukin-6 receptor subunit beta ; CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;Oncostatin-M receptor subunit alpha;
    P05231 IL6_HUMAN 212 20 IL-6; BSF-2;CDF;IFN-beta-2; Interleukin-6 ; B-cell stimulatory factor 2;CTL differentiation factor;Hybridoma growth factor;Interferon beta-2;
    P52292 IMA1_HUMAN 529 478 Importin subunit alpha-1 ; Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha;
    P17181 INAR1_HUMAN 557 46 IFN-R-1;IFN-alpha/beta receptor 1; CRF2-1; Interferon alpha/beta receptor 1; Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;Type I interferon receptor 1;
    P48551 INAR2_HUMAN 515 12 IFN-R-2;IFN-alpha binding protein;IFN-alpha/beta receptor 2; Interferon alpha/beta receptor 2; Interferon alpha binding protein;Type I interferon receptor 2;
    Q14653 IRF3_HUMAN 427 97 IRF-3 ; Interferon regulatory factor 3 {ECO:0000303|PubMed:9566918, ECO:0000303|PubMed:9803267};
    Q13568 IRF5_HUMAN 498 99 IRF-5 ; Interferon regulatory factor 5 ;
    Q92985 IRF7_HUMAN 503 97 IRF-7; Interferon regulatory factor 7;
    P05161 ISG15_HUMAN 165 1500 IP17;hUCRP; Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein;Interferon-induced 17 kDa protein;Ubiquitin cross-reactive protein;
    P20701 ITAL_HUMAN 1170 389 LFA-1A; Integrin alpha-L ; CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;Leukocyte function-associated molecule 1 alpha chain;
    Q13241 KLRD1_HUMAN 179 585 Natural killer cells antigen CD94; KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;
    Q16553 LY6E_HUMAN 131 0 Ly-6E; RIG-E;SCA-2;TSA-1; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein;Stem cell antigen 2;Thymic shared antigen 1;
    Q7Z434 MAVS_HUMAN 540 46 MAVS ; Cardif ;IPS-1;VISA; Mitochondrial antiviral-signaling protein ; CARD adapter inducing interferon beta ;Interferon beta promoter stimulator protein 1;Putative NF-kappa-B-activating protein 031N;Virus-induced-signaling adapter;
    Q86U44 MTA70_HUMAN 580 149 hMETTL3 ;MT-A70; N6-adenosine-methyltransferase catalytic subunit ; Methyltransferase-like protein 3 ;N6-adenosine-methyltransferase 70 kDa subunit;
    Q99836 MYD88_HUMAN 296 61 Myeloid differentiation primary response protein MyD88 ;
    Q9Y6K9 NEMO_HUMAN 419 45 NEMO ; IKKAP1;I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma; NF-kappa-B essential modulator ; FIP-3;IkB kinase-associated protein 1;Inhibitor of nuclear factor kappa-B kinase subunit gamma;NF-kappa-B essential modifier;
    P01185 NEU2_HUMAN 164 29 Vasopressin-neurophysin 2-copeptin; AVP-NPII;
    Q16236 NF2L2_HUMAN 605 12 NF-E2-related factor 2 ;NFE2-related factor 2 ;Nrf-2 ; Nuclear factor erythroid 2-related factor 2 ; HEBP1;Nuclear factor, erythroid derived 2, like 2 {ECO:0000303|PubMed:33009401, ECO:0000303|PubMed:7937919};
    O14745 NHRF1_HUMAN 358 331 NHERF-1; EBP50; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 ; Ezrin-radixin-moesin-binding phosphoprotein 50;Regulatory cofactor of Na(+)/H(+) exchanger;Sodium-hydrogen exchanger regulatory factor 1;Solute carrier family 9 isoform A3 regulatory factor 1;
    P26715 NKG2A_HUMAN 233 415 NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A;NK cell receptor A;NKG2-A/B-activating NK receptor;
    Q9C000 NLRP1_HUMAN 1473 256 NACHT, LRR and PYD domains-containing protein 1 ; Caspase recruitment domain-containing protein 7;Death effector filament-forming ced-4-like apoptosis protein ;Nucleotide-binding domain and caspase recruitment domain;
    Q96P20 NLRP3_HUMAN 1036 181 CLR1.1 ; NACHT, LRR and PYD domains-containing protein 3 ; Angiotensin/vasopressin receptor AII/AVP-like;Caterpiller protein 1.1 ;Cold-induced autoinflammatory syndrome 1 protein ;Cryopyrin ;PYRIN-containing APAF1-like protein 1 ;
    O14786 NRP1_HUMAN 923 228 Neuropilin-1 ; Vascular endothelial cell growth factor 165 receptor;
    P52948 NUP98_HUMAN 1817 209 Nuclear pore complex protein Nup98-Nup96 ;
    P00973 OAS1_HUMAN 400 13 (2-5')oligo(A) synthase 1;2-5A synthase 1; 2'-5'-oligoadenylate synthase 1; E18/E16;p46/p42 OAS;
    Q9H074 PAIP1_HUMAN 479 9 PABP-interacting protein 1;PAIP-1;Poly(A)-binding protein-interacting protein 1; Polyadenylate-binding protein-interacting protein 1 ;
    Q8N3R9 PALS1_HUMAN 675 199 Protein PALS1 ; MAGUK p55 subfamily member 5;Membrane protein, palmitoylated 5 ;Protein associated with Lin-7 1 {ECO:0000303|PubMed:12527193, ECO:0000312|HGNC:HGNC:18669};
    P35232 PHB1_HUMAN 272 1 Prohibitin 1 ;
    Q99623 PHB2_HUMAN 299 1 Prohibitin-2; B-cell receptor-associated protein BAP37;D-prohibitin;Repressor of estrogen receptor activity;
    Q8NEB9 PK3C3_HUMAN 887 543 PI3-kinase type 3;PI3K type 3;PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase p100 subunit;Phosphoinositide-3-kinase class 3;hVps34;
    P62937 PPIA_HUMAN 165 613 PPIase A; Peptidyl-prolyl cis-trans isomerase A; Cyclophilin A;Cyclosporin A-binding protein;Rotamase A;
    P51149 RAB7A_HUMAN 207 1500 Ras-related protein Rab-7a ;
    P05109 S10A8_HUMAN 93 445 CFAG;MRP-8;p8; Protein S100-A8 ; Calgranulin-A;Calprotectin L1L subunit;Cystic fibrosis antigen;Leukocyte L1 complex light chain;Migration inhibitory factor-related protein 8;S100 calcium-binding protein A8;Urinary stone protein band A;
    O43765 SGTA_HUMAN 313 303 UBP; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT;Vpu-binding protein;
    P84022 SMAD3_HUMAN 425 91 MAD homolog 3;Mad3;Mothers against DPP homolog 3;hMAD-3; SMAD 3;Smad3;hSMAD3; Mothers against decapentaplegic homolog 3; JV15-2;SMAD family member 3;
    O95721 SNP29_HUMAN 258 14 SNAP-29 ; Synaptosomal-associated protein 29 ; Soluble 29 kDa NSF attachment protein ;Vesicle-membrane fusion protein SNAP-29;
    P56962 STX17_HUMAN 302 9 Syntaxin-17 ;
    Q9UHD2 TBK1_HUMAN 729 1500 Serine/threonine-protein kinase TBK1 ; NF-kappa-B-activating kinase ;T2K;TANK-binding kinase 1 ;
    Q8IUC6 TCAM1_HUMAN 712 11 TICAM-1; MyD88-3;TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adapter molecule 1; Proline-rich, vinculin and TIR domain-containing protein B;Putative NF-kappa-B-activating protein 502H;Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;
    O15455 TLR3_HUMAN 904 838 Toll-like receptor 3 ;
    Q9NYK1 TLR7_HUMAN 1049 732 Toll-like receptor 7 ;
    Q9NR97 TLR8_HUMAN 1041 620 Toll-like receptor 8 ;
    Q5BJD5 TM41B_HUMAN 291 0 Transmembrane protein 41B ; Protein stasimon ;
    O15393 TMPS2_HUMAN 492 1500 Transmembrane protease serine 2 ; Serine protease 10 ;
    Q9NRS4 TMPS4_HUMAN 437 1500 CAPH2;MT-SP2; Transmembrane protease serine 4 ; Channel-activating protease 2;Membrane-type serine protease 2;
    O94826 TOM70_HUMAN 608 175 Mitochondrial import receptor subunit TOM70 ; Mitochondrial precursor proteins import receptor;Translocase of outer membrane 70 kDa subunit;Translocase of outer mitochondrial membrane protein 70 ;
    Q8NHX9 TPC2_HUMAN 752 152 Two pore channel protein 2; Two pore calcium channel protein 2;
    P29597 TYK2_HUMAN 1187 1500 Non-receptor tyrosine-protein kinase TYK2;
    P47901 V1BR_HUMAN 424 570 V1bR; Vasopressin V1b receptor ; AVPR V1b;AVPR V3;Antidiuretic hormone receptor 1b;Vasopressin V3 receptor;
    Q9BV40 VAMP8_HUMAN 100 50 VAMP-8 ; EDB ; Vesicle-associated membrane protein 8 ; Endobrevin ;
    Q96JC1 VPS39_HUMAN 886 4 hVam6p; Vam6/Vps39-like protein ; TRAP1-like protein;
    P49754 VPS41_HUMAN 854 0 Vacuolar protein sorting-associated protein 41 homolog; S53;
    Q5W0Z9 ZDH20_HUMAN 365 12 DHHC20 ; Palmitoyltransferase ZDHHC20 ; Acyltransferase ZDHHC20 ;DHHC domain-containing cysteine-rich protein 20 ;Zinc finger DHHC domain-containing protein 20 ;
    Q9ULC8 ZDHC8_HUMAN 765 12 DHHC-8 ; Palmitoyltransferase ZDHHC8 ; Zinc finger DHHC domain-containing protein 8 ;Zinc finger protein 378;
    Q9Y397 ZDHC9_HUMAN 364 12 DHHC-9;DHHC9; Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9;Zinc finger protein 379;Zinc finger protein 380;

    Proteins in Genpept(28)

    protein_id length
    (amino acids)
    Number of
    3D homologues
    product gene note
    YP_009724389.1 7096 1500 2'-O-ribose methyltransferase orf1ab pp1ab; translated by -1 ribosomal frameshift
    YP_009725297.1 180 29 leader protein nsp1; produced by both pp1a and pp1ab
    YP_009725298.1 638 8 nsp2 produced by both pp1a and pp1ab
    YP_009725299.1 1945 1239 nsp3 former nsp1; conserved domains are: N-terminal
    YP_009725300.1 500 9 nsp4 nsp4B_TM; contains transmembrane domain 2 (TM2);
    YP_009725301.1 306 1500 3C-like proteinase nsp5A_3CLpro and nsp5B_3CLpro; main proteinase
    YP_009725302.1 290 0 nsp6 nsp6_TM; putative transmembrane domain; produced by
    YP_009725303.1 83 93 nsp7 produced by both pp1a and pp1ab
    YP_009725304.1 198 145 nsp8 produced by both pp1a and pp1ab
    YP_009725305.1 113 64 nsp9 ssRNA-binding protein; produced by both pp1a and
    YP_009725306.1 139 148 nsp10 nsp10_CysHis; formerly known as growth-factor-like
    YP_009725307.1 932 66 RNA-dependent RNA polymerase nsp12; NiRAN and RdRp; produced by pp1ab only
    YP_009725308.1 601 166 helicase nsp13_ZBD, nsp13_TB, and nsp_HEL1core; zinc-binding
    YP_009725309.1 527 92 3'-to-5' exonuclease nsp14A2_ExoN and nsp14B_NMT; produced by pp1ab
    YP_009725310.1 346 165 endoRNAse nsp15-A1 and nsp15B-NendoU; produced by pp1ab only
    YP_009725311.1 298 66 2'-O-ribose methyltransferase nsp16_OMT; 2'-o-MT; produced by pp1ab only
    YP_009725295.1 4405 1500 nsp11 orf1ab pp1a
    YP_009725312.1 13 0 nsp11 produced by pp1a only
    YP_009724390.1 1273 1500 surface glycoprotein S structural protein; spike protein
    YP_009724391.1 275 12 ORF3a protein ORF3a
    YP_009724392.1 75 18 envelope protein E ORF4; structural protein; E protein
    YP_009724393.1 222 12 membrane glycoprotein M ORF5; structural protein
    YP_009724394.1 61 0 ORF6 protein ORF6
    YP_009724395.1 121 4 ORF7a protein ORF7a
    YP_009725318.1 43 0 ORF7b ORF7b
    YP_009724396.1 121 9 ORF8 protein ORF8
    YP_009724397.2 419 256 nucleocapsid phosphoprotein N ORF9; structural protein
    YP_009725255.1 38 0 ORF10 protein ORF10

    Reported Efficient Compounds(26)

    KEGG_ID structure NAME Number of
    identical compounds
    Number of
    similar compounds
    (tanimoto=0.5)
    OTHER NAME EFFICACY
    D01703 D01703 Ciclesonide (JAN/USAN/INN); Alvesco (TN); Omnaris (TN); Zetonna (TN) 0 10 Alvesco (TN); Omnaris (TN); Zetonna (TN) Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
    D01425 D01425 Lopinavir (JAN/USP/INN) 1 39 Antiviral, HIV protease inhibitor
    D00427 D00427 Ritonavir (JAN/USP/INN); Norvir (TN) 1 31 Norvir (TN) Antiviral, HIV protease inhibitor
    D09537 D09537 Favipiravir (JAN/USAN/INN); Avigan (TN) 0 66 Avigan (TN) Antiviral, RNA replicase inhibitor
    D09537_1 D09537_1 Favipiravir-MTP; Active form of Favipiravir; 1 150 Active form of Favipiravir; Antiviral, RNA replicase inhibitor
    D09537_2 D09537_2 Favipiravir-DTP; Active form of Favipiravir; 0 141 Active form of Favipiravir; Antiviral, RNA replicase inhibitor
    D09537_3 D09537_3 Favipiravir-RTP; Active form of Favipiravir; 1 150 Active form of Favipiravir; Antiviral, RNA replicase inhibitor
    D11472 D11472 Remdesivir (JAN/USAN); Veklury (TN) 0 4 Veklury (TN) Antiviral, RNA polymerase inhibitor
    D11472_1 D11472_1 Remdesivir-monophosphate (USAN 1 149 Antiviral
    D11472_2 D11472_2 Remdesivir-diphosphate (USAN 0 134 Antiviral
    D11472_3 D11472_3 Remdesivir-triphosphate (USAN 1 150 Antiviral
    D02366 D02366 Chloroquine (USP/INN) 2 31 Antimalarial, Amebicide
    D08050 D08050 Hydroxychloroquine (INN); Polirreumin (TN) 0 23 Polirreumin (TN) Antimalarial
    D01670 D01670 Nafamostat mesylate (USAN); Nafamostat mesilate (JP18); Ronastat (TN) 1 32 Nafamostat mesilate (JP18); Ronastat (TN) Anticoagulant, Antifibrinolytic, Serine protease inhibitor
    D00429 D00429 Saquinavir (JAN/USP/INN); Fortovase (TN) 1 10 Fortovase (TN) Antiviral, HIV protease inhibitor
    D01035 D01035 Cepharanthine (JAN); Cepharanthine (TN) 0 0 Cepharanthine (TN) Antiallergic, Blood circulation promotor
    D00804 D00804 Ivermectin (JAN/USP/INN); Sklice (TN); Soolantra (TN); Stromectol (TN) 0 1 Sklice (TN); Soolantra (TN); Stromectol (TN) Antiparasitic
    D00292 D00292 Dexamethasone (JP18/USP/INN); Decadron (TN); Maxidex (TN) 1 111 Decadron (TN); Maxidex (TN) Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
    D07486 D07486 Azithromycin (INN); Azasite (TN); Azithromycin (TN) 1 25 Azasite (TN); Azithromycin (TN) Antibacterial, Protein biosynthesis inhibitor
    D08897 D08897 Dapagliflozin (USAN/INN); Forxiga (TN) 1 39 Forxiga (TN) Antidiabetic, SGLT-2 inhibitor
    D00570 D00570 Colchicine (JP18/USP); Colchicine (TN) 1 10 Colchicine (TN) Gout suppressant, Leukocyte (neutrophil) migration inhibitor, Tubulin polymerization inhibitor
    D07606 D07606 Camostat (INN) 0 13 Anti-inflammatory, Serine protease inhibitor
    D10308 D10308 Baricitinib (JAN/USAN/INN); Olumiant (TN) 1 9 Olumiant (TN) Anti-inflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor
    D11943 D11943 Molnupiravir (JAN/USAN); Lagevrio (TN) 0 112 Lagevrio (TN) Antiviral
    D12244 D12244 Nirmatrelvir (JAN/USAN); PF-07321332 3 58 PF-07321332 Antiviral
    D03506 D03506 Cinanserin hydrochloride (USAN) 0 31 Antiviral


    BLAST is employed for the amino acids sequence search, KCOMBU is used for the chemical structure search.

    HOMCOS is developed and maintained by Protein Data Bank Japan, IPR, Osaka University. It is now supported by the project "Platform for Drug Discovery, Informatics, and Structural Life Science" by MEXT, Japan.

    References

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    Last Update:2022/01/19