ID NS7B_SARS Reviewed; 44 AA. AC Q7TFA1; Q7TLC9; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 28-JUN-2023, entry version 55. DE RecName: Full=Protein non-structural 7b; DE Short=ns7b; DE AltName: Full=Accessory protein 7b; GN ORFNames=7b; OS Severe acute respiratory syndrome coronavirus (SARS-CoV). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Sarbecovirus. OX NCBI_TaxID=694009; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9675; Paguma larvata (Masked palm civet). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RC STRAIN=Isolate Urbani; RX PubMed=12730500; DOI=10.1126/science.1085952; RA Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R., RA Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H., Tong S., RA Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D., Erdman D.D., RA Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E., Sanchez A., Liffick S., RA Holloway B., Limor J., McCaustland K., Olsen-Rasmussen M., Fouchier R., RA Guenther S., Osterhaus A.D.M.E., Drosten C., Pallansch M.A., Anderson L.J., RA Bellini W.J.; RT "Characterization of a novel coronavirus associated with severe acute RT respiratory syndrome."; RL Science 300:1394-1399(2003). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RC STRAIN=Isolate Tor2; RX PubMed=12730501; DOI=10.1126/science.1085953; RA Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A., RA Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y., RA Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L., Leach S.R., RA Mayo M., McDonald H., Montgomery S.B., Pandoh P.K., Petrescu A.S., RA Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E., Stott J.M., RA Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N., Bernard K., RA Booth T.F., Bowness D., Czub M., Drebot M., Fernando L., Flick R., RA Garbutt M., Gray M., Grolla A., Jones S., Feldmann H., Meyers A., RA Kabani A., Li Y., Normand S., Stroher U., Tipples G.A., Tyler S., RA Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M., Petric M., RA Skowronski D.M., Upton C., Roper R.L.; RT "The genome sequence of the SARS-associated coronavirus."; RL Science 300:1399-1404(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RC STRAIN=Isolate Frankfurt 1; RX PubMed=12917450; DOI=10.1099/vir.0.19424-0; RA Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S., RA Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E., RA Ziebuhr J.; RT "Mechanisms and enzymes involved in SARS coronavirus genome expression."; RL J. Gen. Virol. 84:2305-2315(2003). RN [4] RP SUBCELLULAR LOCATION. RX PubMed=17037516; DOI=10.1007/978-0-387-33012-9_20; RA Pekosz A., Schaecher S.R., Diamond M.S., Fremont D.H., Sims A.C., RA Baric R.S.; RT "Structure, expression, and intracellular localization of the SARS-CoV RT accessory proteins 7a and 7b."; RL Adv. Exp. Med. Biol. 581:115-120(2006). CC -!- INTERACTION: CC Q7TFA1; P59637: E; NbExp=2; IntAct=EBI-25492846, EBI-25487741; CC Q7TFA1; Q19QW5: ORF6; NbExp=2; IntAct=EBI-25492846, EBI-25493595; CC Q7TFA1; Q7Z434: MAVS; Xeno; NbExp=2; IntAct=EBI-25492846, EBI-995373; CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane CC protein {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY278741; -; NOT_ANNOTATED_CDS; Genomic_RNA. DR EMBL; AY274119; AAP41044.1; -; Genomic_RNA. DR EMBL; AY291315; AAP33704.1; -; Genomic_RNA. DR SMR; Q7TFA1; -. DR BioGRID; 4383921; 260. DR IntAct; Q7TFA1; 255. DR SIGNOR; Q7TFA1; -. DR Proteomes; UP000000354; Genome. DR Proteomes; UP000137377; Genome. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd21635; ORF7b_SARS-CoV-like; 1. DR InterPro; IPR021532; NS7B_bCoV. DR InterPro; IPR044394; ORF7b_SARS-CoV-like. DR Pfam; PF11395; bCoV_NS7B; 1. PE 1: Evidence at protein level; KW Host membrane; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..44 FT /note="Protein non-structural 7b" FT /id="PRO_0000283857" FT TRANSMEM 9..29 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 44 AA; 5302 MW; 7AD647C9E311E04F CRC64; MNELTLIDFY LCFLAFLLFL VLIMLIIFWF SLEIQDLEEP CTKV //