Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
3960881 557 46 P17181(INAR1_HUMAN) RecName: Full=Interferon alpha/beta receptor 1; Short=IFN-R-1; Short=IFN-alpha/beta receptor 1;AltName: Full=Cytokine receptor class-II member 1;AltName: Full=Cytokine receptor family 2 member 1; Short=CRF2-1;AltName: Full=Type I interferon receptor 1;Flags: Precursor;
QUERYSEQ
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDKAIVIHISPGT
KDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQIPDCENVKTTQCVFPQNVFQK
GIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCEKTKPGNTSKIWLIVGICIALFAL
PFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNLLLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P17181(INAR1_HUMAN)]

557
region name description
1-27 SIGNAL
28-557 CHAIN /note="Interferon alpha/beta receptor 1" /id="PRO_0000011001"
28-436 TOPO_DOM /note="Extracellular"
437-457 TRANSMEM /note="Helical"
458-557 TOPO_DOM /note="Cytoplasmic"
32-126 DOMAIN /note="Fibronectin type-III 1"
127-227 DOMAIN /note="Fibronectin type-III 2"
231-329 DOMAIN /note="Fibronectin type-III 3"
331-432 DOMAIN /note="Fibronectin type-III 4"
491-500 REGION /note="Important for interaction with TYK2"
516-557 REGION /note="Disordered"
540-557 COMPBIAS /note="Basic and acidic residues"
463-463 LIPID /note="S-palmitoyl cysteine"
1-557 DISORDER predicted by DISOPRED

MONOMER
557
pdb_id a1 identity[%]2 description
3se3 A 100.0 INAR1_HUMAN Interferon alpha/beta receptor 1
3wcy A 48.9 INAR1_MOUSE Interferon alpha/beta receptor 1
4po6 B 100.0 INAR1_HUMAN Interferon alpha/beta receptor 1
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
557 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3se3[1] B Q86UP4_HUMAN Interferon alpha 2b[128 aa] A 100.0
/100.0
17
/17
INAR1_HUMAN Interferon alpha/beta receptor 1
3se4[1] B IFNW1_HUMAN Interferon omega-1[143 aa] A 100.0
/100.0
20
/20
INAR1_HUMAN Interferon alpha/beta receptor 1
4po6[1] A TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2[475 aa] B 100.0
/100.0
16
/16
INAR1_HUMAN Interferon alpha/beta receptor 1
3wcy[1] B IFNB_MOUSE Interferon beta[160 aa] A 25.0
/48.9
32
/32
INAR1_MOUSE Interferon alpha/beta receptor 1
6x93[1] A IL10_HUMAN Interleukin-10[135 aa] C 18.8
/31.6
16
/18
I10R2_HUMAN Interleukin-10 receptor subunit beta
6x93[1] B I10R1_HUMAN Interleukin-10 receptor subunit alpha[198 aa] C 25.0
/31.6
4
/4
I10R2_HUMAN Interleukin-10 receptor subunit beta
6x93[1] D IL10_HUMAN Interleukin-10[145 aa] F 0.0
/31.6
4
/5
I10R2_HUMAN Interleukin-10 receptor subunit beta
4doh[2] A IL20_HUMAN Interleukin-20[153 aa] C 20.0
/31.3
15
/18
I20RA_HUMAN Interleukin-20 receptor subunit alpha
5t5w[1] B INLR1_HUMAN Interferon lambda receptor 1[188 aa] A 18.2
/30.8
11
/13
I10R2_HUMAN Interleukin-10 receptor subunit beta
5t5w[1] C IFNL3_HUMAN Interferon lambda-3[151 aa] A 16.7
/30.8
12
/13
I10R2_HUMAN Interleukin-10 receptor subunit beta
6df3[1] B IL24_HUMAN Interleukin-24[155 aa] A 18.2
/26.1
11
/14
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6df3[1] B IL24_HUMAN Interleukin-24[155 aa] C 16.7
/29.3
18
/19
I20RB_HUMAN Interleukin-20 receptor subunit beta
6df3[1] A I22R1_HUMAN Interleukin-22 receptor subunit alpha-1[199 aa] C 50.0
/29.3
6
/8
I20RB_HUMAN Interleukin-20 receptor subunit beta
6weo[12] IA I22R1_MOUSE Interleukin-22 receptor subunit alpha-1[201 aa] A 33.3
/29.2
6
/6
I10R2_MOUSE Interleukin-10 receptor subunit beta
6e3k[4] B IFNG_HUMAN Interferon gamma[126 aa] E 15.4
/27.2
13
/14
INGR2_HUMAN Interferon gamma receptor 2
6e3k[4] D INGR1_HUMAN Interferon gamma receptor 1[203 aa] E 5.6
/27.2
18
/19
INGR2_HUMAN Interferon gamma receptor 2
3dgc[3] A IL22_HUMAN Interleukin-22[141 aa] B 23.1
/24.2
13
/16
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[2] C IL22_HUMAN Interleukin-22[141 aa] B 12.5
/24.2
8
/12
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6df3[1] C I20RB_HUMAN Interleukin-20 receptor subunit beta[190 aa] A 25.0
/26.1
8
/8
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6weo[12] JA IL22_MOUSE Interleukin-22[141 aa] A 20.0
/29.2
15
/17
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[12] C IL22_MOUSE Interleukin-22[140 aa] B 40.0
/22.1
10
/13
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[12] D I10R2_MOUSE Interleukin-10 receptor subunit beta[195 aa] B 66.7
/22.1
3
/7
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
557 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
5eh1[5] B CYS
CYSTEINE[7 atoms]
A 0.0
/27.2
3
/3
INGR2_HUMAN Interferon gamma receptor 2
3s98[2] B NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 100.0
/100.0
3
/3
IFNAR1_HUMAN Interferon alpha/beta receptor 1
3se3[2] D NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 100.0
/100.0
1
/1
INAR1_HUMAN Interferon alpha/beta receptor 1
4doh[1] H NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
C 0.0
/31.3
2
/2
I20RA_HUMAN Interleukin-20 receptor subunit alpha
5eh1[5] C NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 40.0
/27.2
5
/5
INGR2_HUMAN Interferon gamma receptor 2
5eh1[3] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 0.0
/27.2
2
/2
INGR2_HUMAN Interferon gamma receptor 2
6df3[1] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 50.0
/26.1
4
/4
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6e3k[2] U NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
E 0.0
/27.2
1
/1
INGR2_HUMAN Interferon gamma receptor 2
6e3l[1] R NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
E 100.0
/27.2
2
/4
INGR2_HUMAN Interferon gamma receptor 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
557 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3dgc[2] H CL
CHLORIDE ION[1 atoms]
B 20.0
/24.2
5
/6
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[1] S CL
CHLORIDE ION[1 atoms]
D 33.3
/24.2
3
/3
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[2] I U1
URANIUM ATOM[1 atoms]
B 0.0
/24.2
1
/1
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[1] J U1
URANIUM ATOM[1 atoms]
B 0.0
/24.2
1
/2
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[2] K U1
URANIUM ATOM[1 atoms]
B 33.3
/24.2
3
/3
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3dgc[1] L U1
URANIUM ATOM[1 atoms]
B 100.0
/24.2
1
/2
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
OTHERPOLY
557 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6df3[1] D 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 20.0
/26.1
5
/6
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6e3k[3] G 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. E 20.0
/27.2
5
/5
INGR2_HUMAN Interferon gamma receptor 2
6weo[1] AB 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. BA 0.0
/29.2
1
/1
I10R2_MOUSE Interleukin-10 receptor subunit beta
6e3l[2] I beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. E 25.0
/27.2
4
/4
INGR2_HUMAN Interferon gamma receptor 2
6weo[1] QA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. K 25.0
/22.1
4
/4
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[1] QA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. M 100.0
/29.2
1
/1
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[1] GB alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(.. A 50.0
/29.2
2
/2
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[4] CB 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. EA 0.0
/29.2
2
/2
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[2] OA 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. H 25.0
/22.1
4
/7
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[1] OA 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. J 0.0
/29.8
1
/1
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[1] RA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. O 0.0
/29.2
2
/2
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[1] UA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. S 25.0
/22.1
4
/8
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[1] UA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. U 100.0
/29.2
1
/1
I10R2_MOUSE Interleukin-10 receptor subunit beta
6e3k[1] H alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. F 20.0
/27.2
5
/5
INGR2_HUMAN Interferon gamma receptor 2
6e3l[1] L alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-.. F 20.0
/27.2
5
/5
INGR2_HUMAN Interferon gamma receptor 2
3dgc[1] E alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(.. B 28.6
/24.2
7
/7
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6weo[3] KA beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. B 25.0
/22.1
4
/8
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[4] BB alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. CA 25.0
/22.1
4
/8
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6weo[3] NA alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. G 50.0
/29.2
2
/2
I10R2_MOUSE Interleukin-10 receptor subunit beta
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
557 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3lqm[2] C SO4
SULFATE ION[5 atoms]
A 40.0
/30.4
5
/5
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[2] D SO4
SULFATE ION[5 atoms]
A 50.0
/30.4
4
/4
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[2] E SO4
SULFATE ION[5 atoms]
A 50.0
/30.4
2
/2
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[1] G SO4
SULFATE ION[5 atoms]
B 50.0
/30.8
4
/6
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[1] H SO4
SULFATE ION[5 atoms]
B 33.3
/30.8
3
/3
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[1] L SO4
SULFATE ION[5 atoms]
B 0.0
/30.8
2
/2
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[1] M SO4
SULFATE ION[5 atoms]
B 100.0
/30.8
2
/2
I10R2_HUMAN Interleukin-10 receptor subunit beta
3lqm[1] F GOL
GLYCEROL[6 atoms]
A 20.0
/30.4
5
/5
I10R2_HUMAN Interleukin-10 receptor subunit beta
5eh1[1] F GOL
GLYCEROL[6 atoms]
A 0.0
/27.2
4
/4
INGR2_HUMAN Interferon gamma receptor 2
5eh1[1] G GOL
GLYCEROL[6 atoms]
A 42.9
/27.2
7
/9
INGR2_HUMAN Interferon gamma receptor 2
5eh1[1] H GOL
GLYCEROL[6 atoms]
A 40.0
/27.2
5
/5
INGR2_HUMAN Interferon gamma receptor 2
6df3[1] F GOL
GLYCEROL[6 atoms]
A 0.0
/26.1
2
/2
I22R1_HUMAN Interleukin-22 receptor subunit alpha-1
6weo[1] JB GOL
GLYCEROL[6 atoms]
R 0.0
/29.2
2
/2
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[2] LB GOL
GLYCEROL[6 atoms]
U 0.0
/29.2
2
/3
I10R2_MOUSE Interleukin-10 receptor subunit beta
6weo[1] MB GOL
GLYCEROL[6 atoms]
W 0.0
/22.1
4
/7
I22R1_MOUSE Interleukin-22 receptor subunit alpha-1
6e3k[1] AA EDO
1,2-ETHANEDIOL[4 atoms]
F 100.0
/27.2
1
/2
INGR2_HUMAN Interferon gamma receptor 2
6e3k[1] BA EDO
1,2-ETHANEDIOL[4 atoms]
F 100.0
/27.2
2
/3
INGR2_HUMAN Interferon gamma receptor 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.