HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

1678758

1187

500

P29597(TYK2_HUMAN)

RecName: Full=Non-receptor tyrosine-protein kinase TYK2; EC=2.7.10.2 ;

QUERYSEQ

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFE
YLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG
IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG
TSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE
GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P29597(TYK2_HUMAN)]

1187
	region	name	description
	1-1187	CHAIN	/note="Non-receptor tyrosine-protein kinase TYK2" /id="PRO_0000088177"
	26-431	DOMAIN	/note="FERM"
	450-529	DOMAIN	/note="SH2; atypical"
	589-875	DOMAIN	/note="Protein kinase 1"
	897-1176	DOMAIN	/note="Protein kinase 2"
	335-366	REGION	/note="Disordered"
	610-629	REGION	/note="Disordered"
	1023-1023	ACT_SITE	/note="Proton acceptor" ECO:0000255\|PROSITE-ProRule:PRU10028"
	903-911	BINDING	/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616"
	930-930	BINDING	/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616"
	1-1187	DISORDER	predicted by DISOPRED

MONOMER

1187

pdb_id a¹ identity[%]² description

4oli A 99.6 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8ewy A 51.5 B1ASP2_MOUSE Tyrosine-protein kinase

4po6 A 100.0 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

1187 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4po6[1] B INAR1_HUMAN Interferon alpha/beta receptor 1[19 aa] A 100.0
/100.0 30
/30 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6c7y[1] B B6RCQ2_CHICK Suppressor of cytokine signaling 1[117 aa] A 53.6
/61.5 28
/28 JAK1_HUMAN Tyrosine-protein kinase JAK1

4gl9[4] G SOCS3_MOUSE Suppressor of cytokine signaling 3,Suppressor of c.. A 50.0
/53.6 20
/21 G5E852_MOUSE Tyrosine-protein kinase

7t6f[4] B INLR1_MOUSE Interferon lambda receptor 1[37 aa] A 58.1
/51.5 31
/31 B1ASP2_MOUSE Tyrosine-protein kinase

5ixd[1] B INLR1_HUMAN Interferon lambda receptor 1[21 aa] A 54.2
/47.2 24
/24 JAK1_HUMAN Tyrosine-protein kinase JAK1

5ixi[1] B INLR1_HUMAN I10R1_HUMAN Chimera protein of Interferon lambda receptor 1 an.. A 60.0
/46.4 25
/26 JAK1_HUMAN Tyrosine-protein kinase JAK1

5l04[1] B INLR1_HUMAN Interferon lambda receptor 1[37 aa] A 39.5
/45.5 43
/44 JAK1_HUMAN Tyrosine-protein kinase JAK1

6e2p[2] C LEPR_HUMAN Leptin receptor[20 aa] A 57.9
/36.1 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6e2q[2] E EPOR_HUMAN Erythropoietin receptor[44 aa] C 37.9
/35.6 29
/29 JAK2_HUMAN Tyrosine-protein kinase JAK2

6e2q[1] F EPOR_HUMAN Erythropoietin receptor[57 aa] A 34.0
/35.7 50
/50 JAK2_HUMAN Tyrosine-protein kinase JAK2

6e2q[1] G EPOR_HUMAN Erythropoietin receptor[52 aa] B 34.0
/35.5 50
/50 JAK2_HUMAN Tyrosine-protein kinase JAK2

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

1187 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4wov[2] C 3SM
2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihy.. A 100.0
/100.0 14
/14 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5c03[2] C AGS
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER[31 atom.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5tkd[3] C 7GL
6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imida.. A 100.0
/100.0 16
/16 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nsl[2] C KZJ
6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-y.. A 100.0
/100.0 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nze[2] C L8Y
4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzf[2] C L91
6-[(5-fluoropyridin-2-yl)amino]-N-methyl-4-{[2-(me.. A 100.0
/100.0 19
/19 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzh[2] C L9A
6-[(cyclopropanecarbonyl)amino]-N-methyl-4-{[2-(me.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzp[2] C LB7
6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1.. A 100.0
/100.0 19
/19 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzq[2] C LB4
6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-met.. A 100.0
/100.0 20
/20 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7ax4[2] C NM7
2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-c.. A 100.0
/100.0 15
/15 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7k7o[2] C VZJ
6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(p.. A 100.0
/100.0 21
/21 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7k7q[2] C VZG
6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethyl.. A 100.0
/100.0 22
/22 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7uyr[1] B OVI
2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5H-pyrrolo[3,4.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7uys[1] B OVC
2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5H-pyr.. A 100.0
/100.0 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s98[3] D ZRU
(8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino.. A 100.0
/100.0 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s99[3] D ZS3
(8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-.. A 100.0
/100.0 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s9a[3] D ZSB
(8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamin.. A 100.0
/100.0 19
/19 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4oli[1] B 2TT
2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-.. A 100.0
/99.6 15
/15 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4oli[1] C 2TT
2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-.. A 100.0
/99.6 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzr[2] C LAJ
N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(p.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5f20[1] B 5U4
3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-y.. A 100.0
/99.3 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6vnv[1] B R4Y
(1S,2S)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hy.. A 100.0
/99.3 20
/20 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6ova[1] B N9G
6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-.. A 100.0
/99.3 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

3nyx[1] B TZ1
N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiad.. A 100.0
/99.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5f1z[1] B 5U3
3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methy.. A 100.0
/98.9 15
/15 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gfm[1] B 0X2
2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benz.. A 81.2
/53.5 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

4gfo[1] G 0X2
2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benz.. A 100.0
/98.9 14
/14 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

3eyg[3] B MI1
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyr.. A 89.5
/61.3 19
/19 Q59GQ2_HUMAN Tyrosine-protein kinase

3lxk[1] B MI1
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyr.. A 66.7
/51.6 21
/21 JAK3_HUMAN Tyrosine-protein kinase JAK3

3lxn[1] B MI1
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyr.. A 100.0
/98.3 19
/19 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4py1[1] B 2YK
6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-p.. A 100.0
/97.9 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6dbk[1] B G5D
4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2... A 100.0
/97.9 20
/20 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6vns[1] B R5D
(1R,2R)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hy.. A 100.0
/97.9 22
/22 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6vnx[1] B R4V
(1S)-2,2-difluoro-N-[(1S,5R,6R)-3-{5-fluoro-2-[(1-.. A 100.0
/97.9 21
/21 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6x8e[2] C UWP
[3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a].. A 84.2
/52.5 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6x8f[2] C UWP
[3-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a].. A 100.0
/98.9 21
/21 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6x8g[1] B UWM
trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1H-pyrazol.. A 100.0
/97.9 20
/20 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gii[1] B 0X6
2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)am.. A 100.0
/97.6 16
/16 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gj2[1] B 0XH
2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]c.. A 100.0
/97.6 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gj3[1] B 0XP
2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclo.. A 100.0
/97.6 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6aah[3] C 9T6
4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrro.. A 80.0
/61.0 15
/15 JAK1_HUMAN Tyrosine-protein kinase JAK1

6aaj[2] C 9T6
4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrro.. A 81.8
/53.8 11
/11 JAK2_HUMAN Tyrosine-protein kinase JAK2

6aak[4] E 9T6
4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrro.. A 83.3
/51.3 12
/12 JAK3_HUMAN Tyrosine-protein kinase JAK3

4e20[1] B 0MY
N-[4-(3-amino-1H-indazol-5-yl)phenyl]-3-chlorobenz.. A 100.0
/91.8 17
/17 TYK2_MOUSE Non-receptor tyrosine-protein kinase TYK2

4e1z[1] B 0MX
N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1.. A 100.0
/91.3 21
/21 TYK2_MOUSE Non-receptor tyrosine-protein kinase TYK2

6n7c[2] C KF1
N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]py.. A 78.9
/62.2 19
/19 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n77[2] C KEJ
N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazo.. A 82.4
/61.6 17
/17 JAK1_HUMAN Tyrosine-protein kinase JAK1

6tpf[2] C NTQ
(1~{S})-2,2-bis(fluoranyl)-~{N}-[4-(3-methyl-6-oxi.. A 88.9
/60.7 18
/18 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n78[1] B KEP
N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl.. A 81.0
/61.9 21
/21 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n79[1] B KES
N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyraz.. A 81.0
/61.8 21
/21 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n7b[1] B KEY
N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazo.. A 84.2
/61.8 19
/19 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n7d[1] B KF4
N-[5-(6-methoxy-1H-indazol-5-yl)-1H-pyrazol-4-yl]p.. A 81.0
/61.8 21
/21 JAK1_HUMAN Tyrosine-protein kinase JAK1

4e5w[2] C 0NT
[4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)p.. A 83.3
/58.9 18
/18 JAK1_HUMAN Tyrosine-protein kinase JAK1

4k6z[1] B 1Q3
(1R,2S)-2-{[8-oxo-2-(1H-pyrazol-4-yl)-5,8-dihydrop.. A 82.4
/61.6 17
/17 JAK1_HUMAN Tyrosine-protein kinase JAK1

6rsb[2] C KGZ
1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[[4-(cyclohexen.. A 87.0
/60.8 23
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

6rsc[2] C KH5
1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piper.. A 86.4
/60.8 22
/22 JAK1_HUMAN Tyrosine-protein kinase JAK1

6rsd[2] C KH8
1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl).. A 87.0
/60.8 23
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

6rse[2] C KHH
methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(c.. A 85.7
/60.8 21
/21 JAK1_HUMAN Tyrosine-protein kinase JAK1

6rsh[2] C KHE
1-[(3~{R},4~{R})-4-(cyanomethyl)-3-fluoranyl-1-[(4.. A 82.6
/60.8 23
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

6smb[2] C LKQ
~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino.. A 82.6
/60.6 23
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

6ggh[2] C EYQ
~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin.. A 83.3
/60.8 18
/18 JAK1_HUMAN Tyrosine-protein kinase JAK1

4e4n[2] C 0NL
tert-butyl [(1R,3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b.. A 89.5
/59.1 19
/19 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ei4[2] C 0Q2
(1R,3R)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyr.. A 78.6
/59.5 14
/14 JAK1_HUMAN Tyrosine-protein kinase JAK1

4iva[1] B 1J5
trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrr.. A 93.8
/51.2 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

4ivb[2] C 1J5
trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrr.. A 82.4
/59.1 17
/17 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ivc[2] C 1J6
(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyr.. A 83.3
/59.1 18
/18 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ivd[2] C 15T
3-(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]p.. A 85.0
/59.3 20
/20 JAK1_HUMAN Tyrosine-protein kinase JAK1

4k77[2] C 1Q4
4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7H)-on.. A 83.3
/61.1 12
/12 JAK1_HUMAN Tyrosine-protein kinase JAK1

5e1e[2] D 5JG
6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piper.. A 80.0
/61.6 15
/15 JAK1_HUMAN Tyrosine-protein kinase JAK1

5wo4[2] C B7V
3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-c.. A 82.4
/58.9 17
/17 JAK1_HUMAN Tyrosine-protein kinase JAK1

6elr[2] C BFK
[3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-met.. A 77.8
/58.8 18
/18 JAK1_HUMAN Tyrosine-Protein Kinase JAK1

6tpe[2] C NTW
2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo.. A 85.7
/61.1 14
/14 JAK1_HUMAN Tyrosine-protein kinase JAK1

5hx8[2] C 66P
4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-.. A 80.0
/60.4 15
/15 JAK1_HUMAN Tyrosine-protein kinase JAK1

6vny[1] B R4S
N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-p.. A 100.0
/97.9 20
/20 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6w8l[1] B R4S
N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-p.. A 85.0
/61.2 20
/20 JAK1_HUMAN Tyrosine-protein kinase JAK1

6hzu[2] C GYQ
2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepy.. A 85.7
/58.9 21
/21 JAK1_HUMAN Tyrosine-protein kinase JAK1

6dbm[1] B G4J
[(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-me.. A 100.0
/98.2 22
/22 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6dbn[1] B G4J
[(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-me.. A 84.2
/61.0 19
/19 JAK1_HUMAN Tyrosine-protein kinase JAK1

6sm8[2] C LKT
2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~.. A 87.0
/58.2 23
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

4fk6[2] C 0UJ
N-({1-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-1,6-dih.. A 81.2
/60.3 16
/16 JAK1_HUMAN Tyrosine-protein kinase JAK1

5khx[1] B 6TE
~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl.. A 78.6
/60.2 14
/14 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n7a[2] E KEV
N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazo.. A 84.2
/62.3 19
/19 JAK1_HUMAN Tyrosine-protein kinase JAK1

4i5c[2] C C5I
3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5.. A 85.0
/61.6 20
/20 JAK1_HUMAN Tyrosine-protein kinase JAK1

3zmm[2] C F9J
5-FLUORO-4-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHOXY].. A 87.5
/53.7 16
/16 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4c61[2] C LMM
N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl.. A 86.7
/53.9 15
/15 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4c62[2] C XWW
N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-me.. A 82.4
/53.7 17
/17 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

2xa4[2] C AZ5
5-CHLORO-N2-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL].. A 86.7
/53.6 15
/15 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

3ugc[1] B 046
5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-me.. A 92.3
/53.8 26
/26 JAK2_HUMAN Tyrosine-protein kinase JAK2

7rn6[1] B 046
5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-me.. A 92.6
/54.5 27
/27 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vn8[2] C 3JW
Baricitinib[26 atoms] A 78.9
/53.3 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6wto[1] D 3JW
Baricitinib[26 atoms] A 77.8
/54.3 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

7teu[1] B I6C
3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2.. A 91.7
/53.8 24
/24 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g6z[2] C YSI
(3R)-3-cyclopentyl-3-[(4M)-4-{5-methyl-2-[(1-methy.. A 88.9
/53.8 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

4d1s[1] B BJG
2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-m.. A 76.5
/53.8 17
/17 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

5aep[1] B QUP
1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,.. A 77.8
/53.7 18
/18 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

6wtq[1] B U8J
N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrro.. A 86.7
/53.7 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

4d0w[1] C VVQ
5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphen.. A 80.0
/53.6 15
/15 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

7ree[1] B 4LY
[3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahy.. A 81.0
/53.6 21
/21 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vne[2] C 2TA
N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-y.. A 81.2
/53.3 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

2b7a[8] C IZA
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDA.. A 81.2
/51.4 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

3lxl[1] B IZA
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDA.. A 81.2
/52.0 16
/16 JAK3_HUMAN Tyrosine-protein kinase JAK3

3lxp[1] B IZA
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDA.. A 100.0
/98.2 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

3e62[1] B 5B1
5-bromo-1H-indazol-3-amine[11 atoms] A 88.9
/53.5 9
/9 JAK2_HUMAN Tyrosine-protein kinase JAK2

3e63[1] B 5B2
5-phenyl-1H-indazol-3-amine[16 atoms] A 84.6
/53.5 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

3e64[1] B 5B3
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesul.. A 82.4
/53.5 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

4d0x[1] B 953
5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoro.. A 81.2
/53.5 16
/16 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

3io7[1] B 1P5
(3S)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)py.. A 88.2
/53.4 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

3jy9[1] B JZH
(3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triaza.. A 85.7
/53.4 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

4yti[1] B VJK
(2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl.. A 81.2
/53.3 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

5wal[1] B 9ZS
N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin.. A 100.0
/97.6 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5wev[1] B 9ZS
N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin.. A 90.0
/53.3 10
/10 JAK2_HUMAN Tyrosine-protein kinase JAK2

4bbe[4] E 3O4
N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4.. A 91.7
/53.3 12
/12 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4bbf[4] E O19
(2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimi.. A 82.4
/53.3 17
/17 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

5tq5[1] B 7GX
6-(2-ethyl-4-hydroxyphenyl)-N-(6-methylpyridin-3-y.. A 94.1
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

5tq8[1] B 7GS
{2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazo.. A 80.0
/53.3 20
/20 JAK2_HUMAN Tyrosine-protein kinase JAK2

4ytf[1] B 4HZ
N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5.. A 82.4
/53.2 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

3iok[1] B 1P6
3-(6-{[(1S)-1-(4-fluorophenyl)ethyl]amino}pyrimidi.. A 81.2
/53.1 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

3kck[1] B 3KC
3-chloro-4-(4H-3,4,7-triazadibenzo[cd,f]azulen-6-y.. A 86.7
/53.1 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

4yth[1] B 467
N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5.. A 82.4
/53.1 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6bbu[1] B D7D
N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a.. A 76.5
/61.0 17
/17 JAK1_HUMAN Tyrosine-protein kinase JAK1

6bbv[1] B D7D
N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a.. A 82.4
/53.1 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

7uyu[2] B OV0
2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbony.. A 100.0
/100.0 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7q7i[1] B 9I8
4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinaz.. A 92.9
/53.1 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

7q7k[1] B 9I5
4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol[20 at.. A 92.3
/53.1 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

7q7w[1] B 9HR
4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{S})-1-.. A 81.0
/53.1 21
/21 JAK2_HUMAN Tyrosine-protein kinase JAK2

6dud[1] B HB4
N-[(1S)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-di.. A 83.3
/53.0 12
/12 JAK3_HUMAN Tyrosine-protein kinase JAK3

8g8x[2] C YT8
3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol.. A 92.3
/53.8 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

4ytc[1] B 4HW
N~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1H-1.. A 83.3
/53.0 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

6hzv[4] E GYW
3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanyliden.. A 80.0
/52.3 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

5l3a[1] B 6DP
~{N}-(1~{H}-indazol-4-yl)methanesulfonamide[14 ato.. A 88.9
/52.9 9
/9 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g8o[2] C YT0
[1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]p.. A 81.2
/53.6 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

6db3[1] B G54
[(1S)-1-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl).. A 80.0
/52.8 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

7q7l[1] B 9I2
4-[2-azanyl-8-[[(2~{S})-1-oxidanylpropan-2-yl]amin.. A 89.5
/52.8 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

5tq6[2] C 7GV
{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrim.. A 88.9
/52.5 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

5tts[1] B 7KU
1-{(3R)-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino].. A 78.6
/52.6 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

6db4[1] B G4Y
N-[(1S)-6-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-y.. A 73.3
/52.6 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

3zc6[4] E VFC
N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-p.. A 76.2
/50.9 21
/21 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

3zep[4] E 1NX
2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy.. A 73.7
/52.2 19
/19 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

4hvi[1] B 19S
2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)prop.. A 76.5
/52.4 17
/17 JAK3_HUMAN Tyrosine-protein kinase JAK3

4qt1[1] B 3C9
1-{(3S)-1-[(2-methylpropyl)sulfonyl]piperidin-3-yl.. A 75.0
/52.4 16
/16 JAK3_HUMAN Tyrosine-protein kinase JAK3

6tpd[1] B QZ8
3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridi.. A 88.9
/52.4 9
/9 JAK2_HUMAN Tyrosine-protein kinase JAK2

4qps[2] C 37Q
N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol.. A 80.0
/51.9 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

6wtp[1] B U8P
tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfo.. A 85.7
/52.2 21
/21 JAK2_HUMAN Tyrosine-protein kinase JAK2

7apg[4] E RQT
~{N}-[3-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]p.. A 83.3
/52.6 12
/12 JAK3_HUMAN Tyrosine-protein kinase JAK3

4hvh[1] B 19R
2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl.. A 73.3
/52.2 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

5ttv[1] B 7KX
N-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propa.. A 83.3
/52.2 12
/12 JAK3_HUMAN Tyrosine-protein kinase JAK3

5tq7[2] C 7GT
{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrim.. A 84.2
/51.8 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

4hvd[1] C 933
2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-p.. A 80.0
/52.0 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

4i6q[1] C 1DT
N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2.. A 78.6
/52.0 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

3lpb[2] C NVB
N-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5.. A 83.3
/53.8 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

5cf8[2] C 50V
N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl.. A 88.2
/51.6 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

5wfj[1] B 9Z4
4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo.. A 80.0
/51.9 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

4z16[4] E 4LH
N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazi.. A 80.0
/51.9 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

7uyt[1] B OV5
6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrr.. A 100.0
/100.0 18
/18 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7uyv[4] E OV5
6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrr.. A 76.9
/51.8 13
/13 JAK3_HUMAN Tyrosine-protein kinase JAK3

5ttu[1] B 7KV
1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)oc.. A 73.3
/51.9 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

4hvg[1] B 19Q
2-cyclopropyl-N-[(2S)-3-hydroxy-3-methylbutan-2-yl.. A 80.0
/51.8 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

5toz[1] B 7H4
1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin.. A 78.6
/51.8 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

4hvd[2] B PHU
1-phenylurea[10 atoms] A 88.9
/52.0 9
/9 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwm[14] C PHU
1-phenylurea[10 atoms] A 88.9
/50.9 9
/9 JAK3_HUMAN Tyrosine-protein kinase JAK3

7q6h[1] D PHU
1-phenylurea[10 atoms] A 88.9
/51.8 9
/9 JAK3_HUMAN Tyrosine-protein kinase JAK3

6da4[1] B G4V
(Z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7H-pyrro.. A 76.9
/51.8 13
/13 JAK3_HUMAN Tyrosine-protein kinase JAK3

7q6h[1] B 934
1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8.. A 78.6
/51.8 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

3tjc[2] C 0TP
4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thien.. A 86.7
/51.4 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

3tjd[2] C 6TP
4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methyl.. A 80.0
/51.4 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

4hge[2] C 15V
N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyr.. A 86.7
/51.4 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

5cf6[2] C 50O
N,N-dicyclopropyl-6-[(2S)-2,3-dihydroxypropyl]-1-m.. A 88.2
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

5w86[4] E 9YV
4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)car.. A 71.4
/50.9 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

4e6d[2] C 0NU
3-[(3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6.. A 75.0
/51.6 20
/20 JAK2_HUMAN Tyrosine-protein kinase JAK2

5cf4[2] C 50Y
N,N-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amin.. A 83.3
/53.6 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

7ll5[1] C Y5G
{1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-.. A 81.0
/51.6 21
/21 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnb[2] C R6P
(3S)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phe.. A 88.2
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnc[4] C R6V
(3R)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phe.. A 78.9
/53.3 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnf[2] C R6S
N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-.. A 82.4
/53.5 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnh[2] C XZS
N-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl).. A 94.1
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnj[2] C R5S
3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihy.. A 87.5
/53.3 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnl[4] E 5W2
4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl.. A 87.5
/53.3 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vnm[2] C R5Y
4-[1-(but-3-en-1-yl)-1H-pyrazol-4-yl]-N-[4-(piperi.. A 82.4
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vsn[4] E RG4
(3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidi.. A 86.7
/53.3 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

7ll4[1] B Y5D
{1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylp.. A 81.0
/51.5 21
/21 JAK2_HUMAN Tyrosine-protein kinase JAK2

5vo6[1] B 9J4
4-{[(1R,3S)-3-amino-2,2,3-trimethylcyclopentyl]ami.. A 81.2
/51.5 16
/16 JAK3_HUMAN Tyrosine-protein kinase JAK3

4gvj[1] B ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 100.0
/97.9 16
/16 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5khw[2] C ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 75.0
/61.4 16
/16 JAK1_HUMAN Tyrosine-protein kinase JAK1

6c7y[1] C ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 83.3
/61.5 18
/18 JAK1_HUMAN Tyrosine-protein kinase JAK1

7t6f[4] F ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 83.3
/51.5 12
/12 B1ASP2_MOUSE Tyrosine-protein kinase

7t6f[4] E ADN
ADENOSINE[19 atoms] A 80.0
/51.5 5
/5 B1ASP2_MOUSE Tyrosine-protein kinase

7apf[2] C RQZ
3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]p.. A 75.0
/50.9 12
/12 JAK3_HUMAN Tyrosine-protein kinase JAK3

2w1i[1] C L0I
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-.. A 83.3
/51.4 12
/12 JAK2_HUMAN JAK2

3rvg[1] B 17P
1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5.. A 78.6
/51.4 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

3q32[2] C J2I
2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methy.. A 85.0
/51.4 20
/20 JAK2_HUMAN Tyrosine-protein kinase JAK2

4aqc[2] C 88A
8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphen.. A 77.8
/51.0 18
/18 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4e4l[3] E 0NH
1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-.. A 87.5
/62.0 16
/16 JAK1_HUMAN Tyrosine-protein kinase JAK1

4e4m[4] E 0NH
1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-.. A 86.7
/51.4 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

4gih[1] B 0X5
2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyri.. A 100.0
/97.6 17
/17 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gmy[1] B 0X5
2,6-dichloro-N-{2-[(cyclopropylcarbonyl)amino]pyri.. A 92.3
/51.4 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

4jia[1] B 1K3
5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)p.. A 76.9
/51.4 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

4zim[2] C 4OK
3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-.. A 76.9
/53.3 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

5cf5[2] C 50W
N,N-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-y.. A 88.9
/51.2 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vng[2] C R6M
N-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-.. A 82.4
/53.3 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

5tq3[2] C 7GZ
4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-3-eth.. A 88.2
/51.1 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vni[2] C R61
2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl).. A 84.2
/53.3 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6vgl[8] E RXT
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidi.. A 81.2
/53.3 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

6wtn[1] E RXT
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidi.. A 82.4
/51.1 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

4rio[1] B 3QX
4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyr.. A 85.7
/51.1 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

4ehz[4] E JAK
2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5.. A 78.6
/60.9 14
/14 JAK1_HUMAN Tyrosine-protein kinase JAK1

4f09[1] B JAK
2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5.. A 84.6
/51.1 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

4f08[2] C 1RS
1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrol.. A 90.9
/51.1 11
/11 JAK2_HUMAN Tyrosine-protein kinase JAK2

6gl9[2] C F3W
(~{E})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo.. A 80.0
/51.1 15
/15 JAK3_HUMAN Tyrosine-protein kinase JAK3

4e6q[2] C 0NV
1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-.. A 78.9
/51.0 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

6gla[2] C F4B
(~{E})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo.. A 78.6
/50.9 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

6glb[2] C F48
3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0... A 71.4
/50.9 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

7c3n[1] B FHX
3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-.. A 73.7
/50.9 19
/19 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwm[1] B 79T
2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricycl.. A 85.7
/50.9 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwn[1] I 79R
(~{Z})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},.. A 78.6
/50.9 14
/14 JAK3_HUMAN Tyrosine-protein kinase JAK3

5tq4[1] B 7GY
6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxam.. A 90.0
/50.9 10
/10 JAK2_HUMAN Tyrosine-protein kinase JAK2

4v0g[2] C G9B
N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-.. A 86.7
/51.7 15
/15 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

6ny4[1] B Z3A
4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-pheny.. A 81.2
/50.7 16
/16 JAK3_HUMAN Tyrosine-protein kinase JAK3

3pjc[1] B PJC
3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(tr.. A 77.8
/50.7 18
/18 JAK3_HUMAN Tyrosine-protein kinase JAK3

4ji9[10] C 1M3
N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin.. A 82.4
/51.4 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] G 1M3
N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin.. A 90.0
/50.7 10
/10 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] K 1M3
N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin.. A 100.0
/50.7 1
/1 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] N 1M3
N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin.. A 25.0
/50.7 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

1yvj[1] B DTV
(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL[8 atoms] A 70.0
/50.5 10
/10 JAK3_HUMAN Tyrosine-protein kinase JAK3

1yvj[1] C DTV
(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL[8 atoms] A 25.0
/50.5 4
/4 JAK3_HUMAN Tyrosine-protein kinase JAK3

1yvj[1] D 4ST
1,2,3,4-TETRAHYDROGEN-STAUROSPORINE[35 atoms] A 76.5
/50.5 17
/17 JAK3_HUMAN Tyrosine-protein kinase JAK3

7jyo[1] B VPS
3-({4-amino-6-[(4-cyanophenyl)amino]-1,3,5-triazin.. A 41.7
/49.0 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

6occ[1] C M57
2-[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1H-1,2.. A 61.1
/47.5 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

6bss[1] C 4SP
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURI.. A 45.5
/47.4 11
/11 JAK2_HUMAN Tyrosine-protein kinase JAK2

3krr[2] B DQX
8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-.. A 77.3
/53.6 22
/22 JAK2_HUMAN Tyrosine-protein kinase JAK2

3zon[1] B IK1
5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE[18 atoms].. A 100.0
/100.0 13
/13 TYK2_HUMAN NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2

5ut3[1] B IK1
5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE[18 atoms].. A 55.6
/47.2 9
/9 JAK2_HUMAN Tyrosine-protein kinase JAK2

4p7e[3] C 2HB
N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phe.. A 80.0
/51.6 20
/20 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut1[1] F 7DZ
(7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-d.. A 53.8
/47.2 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut2[1] D 3YT
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2.. A 58.3
/47.2 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut6[1] B 8MY
4-({4-amino-6-[3-(hydroxymethyl)-1H-pyrazol-1-yl]p.. A 50.0
/47.2 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

5wij[3] B AQG
4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N.. A 46.2
/47.2 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

5wik[1] B 584
(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-d.. A 60.0
/47.2 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

5wil[1] B YDJ
5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-t.. A 61.5
/47.2 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

6brw[1] B 5BS
4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5.. A 53.3
/47.2 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

6bs0[1] B E4V
4-(5-aminopyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6.. A 55.6
/47.2 9
/9 JAK2_HUMAN Tyrosine-protein kinase JAK2

6m9h[1] B J9D
4-({4-amino-6-[4-(2-hydroxyethyl)-1H-imidazol-1-yl.. A 50.0
/47.2 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

6oav[1] B M3A
5-amino-3-[(4-cyanophenyl)amino]-N-phenyl-1H-1,2,4.. A 57.1
/47.2 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

6obb[1] B M3Y
5-amino-N-phenyl-3-[(4-sulfamoylphenyl)amino]-1H-1.. A 53.3
/47.2 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

6obf[1] C M4G
[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4.. A 58.8
/47.2 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6obl[1] B M4P
[4-({5-amino-3-[(4-cyanophenyl)amino]-1H-1,2,4-tri.. A 63.2
/47.2 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

7jyq[1] C VPJ
N~2~-(4-fluorophenyl)-6-{[(5-{[(oxolan-2-yl)methyl.. A 45.5
/47.2 11
/11 JAK2_HUMAN Tyrosine-protein kinase JAK2

7t0p[2] C E3W
4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triaz.. A 63.6
/47.2 22
/22 JAK2_HUMAN Tyrosine-protein kinase JAK2

7t1t[1] B E8I
(2S)-2-[({4-[(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4.. A 68.4
/47.2 19
/19 JAK2_HUMAN Tyrosine-protein kinase JAK2

8b9e[2] D Q7F
6-[[methyl-[(3-methylthiophen-2-yl)methyl]amino]me.. A 46.2
/46.8 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

8bak[2] G AD5
N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-p.. A 50.0
/46.8 10
/10 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ex2[1] B Q2Q
3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,.. A 50.0
/47.2 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

6g3c[2] C EKT
2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,.. A 55.6
/46.8 18
/18 Q506Q0_HUMAN Tyrosine-protein kinase

6xjk[1] B V4D
4-({4-amino-6-[(1H-indol-5-yl)oxy]-1,3,5-triazin-2.. A 46.7
/47.1 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usy[3] C SKE
4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,.. A 81.8
/53.8 11
/11 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usz[3] B SKE
4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,.. A 53.3
/47.2 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut0[4] D 35R
1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-be.. A 50.0
/47.2 10
/10 JAK2_HUMAN Tyrosine-protein kinase JAK2

7f7w[2] C 36H
2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl.. A 50.0
/46.8 16
/16 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ba2[1] H Q9X
6-[[(5-bromanylthiophen-2-yl)methyl-methyl-amino]m.. A 46.2
/46.8 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ba3[2] B Q8U
1-(3,4-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11).. A 70.6
/47.2 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

8bab[1] I Q8N
6-[(1-methylimidazol-2-yl)sulfanylmethyl]-~{N}4-(3.. A 46.2
/46.8 13
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

8b8u[2] D T7I
3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,.. A 42.9
/46.8 14
/14 JAK2_HUMAN Tyrosine-protein kinase JAK2

4fvq[2] B ATP
ADENOSINE-5'-TRIPHOSPHATE[31 atoms] A 66.7
/47.2 18
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

5i4n[1] B ATP
ADENOSINE-5'-TRIPHOSPHATE[31 atoms] A 64.7
/46.5 17
/17 JAK2_HUMAN Tyrosine-protein kinase JAK2

6kzc[1] B DZC
3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~.. A 77.3
/46.3 22
/22 NTRK3_HUMAN NT-3 growth factor receptor

6kzd[1] B DZ6
3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl].. A 73.7
/46.1 19
/19 NTRK3_HUMAN NT-3 growth factor receptor

4ymj[2] C 4EJ
4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]ben.. A 83.3
/46.3 12
/12 NTRK3_HUMAN NT-3 growth factor receptor

1u4d[2] C DBQ
DEBROMOHYMENIALDISINE[18 atoms] A 45.5
/41.9 11
/11 ACK1_HUMAN Activated CDC42 kinase 1

6vqm[2] C R7P
2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-metho.. A 68.8
/42.4 16
/16 ACK1_HUMAN Activated CDC42 kinase 1

7kp6[2] C WTP
5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N.. A 71.4
/42.4 14
/14 ACK1_HUMAN Activated CDC42 kinase 1

4id7[2] B 1G0
cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]py.. A 64.7
/42.6 17
/17 ACK1_HUMAN Activated CDC42 kinase 1

4at5[1] B MUJ
5-{3-methoxy-4-[(4-methoxybenzyl)oxy]benzyl}pyrimi.. A 75.0
/42.6 16
/16 NTRK2_HUMAN BDNF/NT-3 GROWTH FACTORS RECEPTOR

3eqr[3] C T74
N~3~-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbut.. A 70.0
/42.6 20
/20 ACK1_HUMAN Activated CDC42 kinase 1

3eqp[3] C T95
N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-({4-[.. A 80.0
/42.4 20
/20 ACK1_HUMAN Activated CDC42 kinase 1

4at4[1] B T6E
1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3.. A 80.0
/42.4 20
/20 NTRK2_HUMAN BDNF/NT-3 GROWTH FACTORS RECEPTOR

1u54[1] H ACP
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER[31 at.. B 73.3
/42.2 15
/15 ACK1_HUMAN Activated CDC42 kinase 1

4ewh[2] C T77
6-{4-[2-(dimethylamino)ethoxy]phenyl}-N-(1,3-dithi.. A 80.0
/42.1 15
/15 ACK1_HUMAN Activated CDC42 kinase 1

8fe9[1] B R9B
N-[(1S)-1-benzyl-2-[(6-chloro-2-oxo-1H-quinolin-4-.. A 78.6
/42.0 14
/14 ACK1_HUMAN Activated CDC42 kinase 1

7wcx[1] B 90F
~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-.. A 76.9
/41.6 13
/14 FGFR4_HUMAN Fibroblast growth factor receptor 4

7ybx[1] B IH7
~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl.. A 64.7
/41.6 17
/18 FGFR4_HUMAN Fibroblast growth factor receptor 4

6yq1[1] H P7N
~{N}-methyl-~{N}-[3-[[[2-[(2-oxidanylidene-3,4-dih.. B 63.6
/40.8 22
/22 FAK1_HUMAN Focal adhesion kinase 1

5wr7[1] B RCH
N-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonyla.. A 70.8
/40.7 24
/24 NTRK1_HUMAN High affinity nerve growth factor receptor

4k9y[1] B K9Y
1-[4-(6-amino-9H-purin-9-yl)phenyl]-3-[3-tert-buty.. A 50.0
/40.6 20
/20 FAK1_HUMAN Focal adhesion kinase 1

7xbi[1] B CVY
4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoy.. A 75.0
/40.3 24
/24 NTRK1_HUMAN High affinity nerve growth factor receptor

4gu6[1] C 10N
N-(3-{[(5-cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-.. A 64.7
/39.7 17
/17 FAK1_HUMAN Focal adhesion kinase 1

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

METAL

1187 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

7ax4[2] D CA
CALCIUM ION[1 atoms] A 100.0
/100.0 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

1u54[2] F MG
MAGNESIUM ION[1 atoms] B 100.0
/42.2 1
/1 ACK1_HUMAN Activated CDC42 kinase 1

4fvq[2] C MG
MAGNESIUM ION[1 atoms] A 100.0
/47.2 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

4gvj[2] C MG
MAGNESIUM ION[1 atoms] A 100.0
/97.9 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5c03[2] D MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5i4n[1] C MG
MAGNESIUM ION[1 atoms] A 100.0
/46.5 1
/1 JAK2_HUMAN Tyrosine-protein kinase JAK2

5khw[2] D MG
MAGNESIUM ION[1 atoms] A 100.0
/61.4 2
/2 JAK1_HUMAN Tyrosine-protein kinase JAK1

6c7y[2] D MG
MAGNESIUM ION[1 atoms] A 100.0
/61.5 2
/2 JAK1_HUMAN Tyrosine-protein kinase JAK1

3jy9[1] C NA
SODIUM ION[1 atoms] A 0.0
/53.4 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

6elr[1] E NA
SODIUM ION[1 atoms] B 33.3
/61.3 3
/3 JAK1_HUMAN Tyrosine-Protein Kinase JAK1

5hez[8] F ZN
ZINC ION[1 atoms] A 50.0
/50.7 2
/2 JAK2_HUMAN Tyrosine-protein kinase JAK2

1u4d[1] D CL
CHLORIDE ION[1 atoms] B 20.0
/43.0 5
/5 ACK1_HUMAN Activated CDC42 kinase 1

3eqp[2] D CL
CHLORIDE ION[1 atoms] A 33.3
/42.4 3
/4 ACK1_HUMAN Activated CDC42 kinase 1

3zc6[1] G CL
CHLORIDE ION[1 atoms] A 50.0
/50.9 2
/2 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

3zc6[2] H CL
CHLORIDE ION[1 atoms] A 0.0
/50.9 2
/2 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

3zc6[1] I CL
CHLORIDE ION[1 atoms] A 50.0
/50.9 4
/4 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

5hez[6] E CL
CHLORIDE ION[1 atoms] A 0.0
/50.7 1
/1 JAK2_HUMAN Tyrosine-protein kinase JAK2

6nzp[1] E CL
CHLORIDE ION[1 atoms] A 100.0
/100.0 1
/1 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nzp[1] E CL
CHLORIDE ION[1 atoms] B 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7kp6[1] D CL
CHLORIDE ION[1 atoms] A 25.0
/42.4 4
/5 ACK1_HUMAN Activated CDC42 kinase 1

7kp6[1] E CL
CHLORIDE ION[1 atoms] A 40.0
/42.4 5
/5 ACK1_HUMAN Activated CDC42 kinase 1

7uyv[1] I CL
CHLORIDE ION[1 atoms] D 0.0
/51.9 2
/2 JAK3_HUMAN Tyrosine-protein kinase JAK3

7xbi[1] C CL
CHLORIDE ION[1 atoms] A 0.0
/40.3 3
/3 NTRK1_HUMAN High affinity nerve growth factor receptor

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

1187 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4wov[2] B TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2[256 aa] A 100.0
/100.0 10
/10 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5tkd[2] B TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2[247 aa] A 100.0
/100.0 12
/12 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6nze[16] B TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2[254 aa] A 100.0
/100.0 7
/7 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4e5w[8] B JAK1_HUMAN Tyrosine-protein kinase JAK1[280 aa] A 50.0
/58.9 20
/20 JAK1_HUMAN Tyrosine-protein kinase JAK1

6aah[1] B JAK1_HUMAN Tyrosine-protein kinase JAK1[286 aa] A 50.0
/61.0 6
/6 JAK1_HUMAN Tyrosine-protein kinase JAK1

6aah[1] A JAK1_HUMAN Tyrosine-protein kinase JAK1[285 aa] B 14.3
/60.8 7
/7 JAK1_HUMAN Tyrosine-protein kinase JAK1

4l00[4] B JAK1_HUMAN Tyrosine-protein kinase JAK1[278 aa] A 57.9
/56.7 19
/23 JAK1_HUMAN Tyrosine-protein kinase JAK1

5hez[8] B JAK2_HUMAN Tyrosine-protein kinase JAK2[291 aa] A 31.2
/50.7 16
/18 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] B JAK2_HUMAN Tyrosine-protein kinase JAK2[291 aa] A 28.6
/50.7 7
/7 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] C JAK2_HUMAN Tyrosine-protein kinase JAK2[291 aa] A 66.7
/50.7 15
/15 JAK2_HUMAN Tyrosine-protein kinase JAK2

5hez[8] D JAK2_HUMAN Tyrosine-protein kinase JAK2[291 aa] A 33.3
/50.7 12
/12 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g6z[2] B JAK2_HUMAN Tyrosine-protein kinase JAK2[280 aa] A 0.0
/53.8 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g8o[4] B JAK2_HUMAN Tyrosine-protein kinase JAK2[279 aa] A 27.3
/53.6 11
/13 JAK2_HUMAN Tyrosine-protein kinase JAK2

6aak[2] B JAK3_HUMAN Tyrosine-protein kinase JAK3[285 aa] A 9.1
/51.3 11
/11 JAK3_HUMAN Tyrosine-protein kinase JAK3

6aak[2] A JAK3_HUMAN Tyrosine-protein kinase JAK3[277 aa] B 0.0
/50.9 10
/10 JAK3_HUMAN Tyrosine-protein kinase JAK3

7t6f[4] D B1ASP2_MOUSE Tyrosine-protein kinase[1045 aa] A 66.7
/51.5 12
/12 B1ASP2_MOUSE Tyrosine-protein kinase

3eqp[6] B ACK1_HUMAN Activated CDC42 kinase 1[268 aa] A 0.0
/42.4 7
/11 ACK1_HUMAN Activated CDC42 kinase 1

4ewh[1] B ACK1_HUMAN Activated CDC42 kinase 1[275 aa] A 0.0
/42.1 3
/3 ACK1_HUMAN Activated CDC42 kinase 1

4ewh[1] A ACK1_HUMAN Activated CDC42 kinase 1[274 aa] B 0.0
/42.1 3
/3 ACK1_HUMAN Activated CDC42 kinase 1

6vqm[2] B ACK1_HUMAN Activated CDC42 kinase 1[267 aa] A 0.0
/42.4 10
/16 ACK1_HUMAN Activated CDC42 kinase 1

4gu6[1] B FAK1_HUMAN Focal adhesion kinase 1[258 aa] A 45.5
/39.7 11
/11 FAK1_HUMAN Focal adhesion kinase 1

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

1187 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4c61[4] D ACT
ACETATE ION[3 atoms] A 20.0
/53.9 5
/5 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4c61[2] G ACT
ACETATE ION[3 atoms] B 66.7
/55.4 3
/3 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4fvq[3] D ACT
ACETATE ION[4 atoms] A 100.0
/47.2 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

4fvq[1] E ACT
ACETATE ION[4 atoms] A 66.7
/47.2 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut0[2] E ACT
ACETATE ION[4 atoms] A 75.0
/47.2 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut5[1] G ACT
ACETATE ION[4 atoms] A 66.7
/47.2 6
/6 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut6[1] I ACT
ACETATE ION[4 atoms] A 50.0
/47.2 2
/2 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ba2[1] E ACT
ACETATE ION[4 atoms] A 33.3
/46.8 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ba2[1] F ACT
ACETATE ION[4 atoms] A 0.0
/46.8 3
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

8s99[8] F ACT
ACETATE ION[4 atoms] A 100.0
/100.0 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s9a[1] E ACT
ACETATE ION[4 atoms] A 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s9a[1] V ACT
ACETATE ION[4 atoms] C 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

8s9a[1] W ACT
ACETATE ION[4 atoms] C 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4ehz[4] F EDO
1,2-ETHANEDIOL[4 atoms] A 66.7
/60.9 6
/6 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[2] G EDO
1,2-ETHANEDIOL[4 atoms] A 42.9
/60.9 7
/7 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[23] H EDO
1,2-ETHANEDIOL[4 atoms] A 75.0
/60.9 4
/4 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[3] I EDO
1,2-ETHANEDIOL[4 atoms] A 25.0
/60.9 4
/4 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[1] J EDO
1,2-ETHANEDIOL[4 atoms] A 25.0
/60.9 4
/4 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[14] O EDO
1,2-ETHANEDIOL[4 atoms] C 100.0
/61.6 2
/2 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[1] Q EDO
1,2-ETHANEDIOL[4 atoms] C 85.7
/61.6 7
/7 JAK1_HUMAN Tyrosine-protein kinase JAK1

4ehz[1] T EDO
1,2-ETHANEDIOL[4 atoms] D 25.0
/61.3 4
/5 JAK1_HUMAN Tyrosine-protein kinase JAK1

4gfo[1] D EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/98.9 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4gfo[8] E EDO
1,2-ETHANEDIOL[4 atoms] A 83.3
/98.9 6
/6 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4hzr[1] D EDO
1,2-ETHANEDIOL[4 atoms] A 66.7
/42.4 6
/6 ACK1_HUMAN Activated CDC42 kinase 1

5c01[3] D EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2

5c01[3] E EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/100.0 5
/5 TYK2_HUMAN NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2

5c03[2] G EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5c03[8] J EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5c03[17] P EDO
1,2-ETHANEDIOL[4 atoms] B 100.0
/100.0 5
/5 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5lwm[4] E EDO
1,2-ETHANEDIOL[4 atoms] A 0.0
/50.9 3
/3 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwm[9] G EDO
1,2-ETHANEDIOL[4 atoms] A 25.0
/50.9 4
/4 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwm[6] H EDO
1,2-ETHANEDIOL[4 atoms] A 33.3
/50.9 3
/5 JAK3_HUMAN Tyrosine-protein kinase JAK3

5lwn[3] G EDO
1,2-ETHANEDIOL[4 atoms] A 16.7
/50.9 6
/6 JAK3_HUMAN Tyrosine-protein kinase JAK3

6c7y[2] G EDO
1,2-ETHANEDIOL[4 atoms] A 33.3
/61.5 3
/3 JAK1_HUMAN Tyrosine-protein kinase JAK1

6c7y[1] H EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/61.5 1
/1 JAK1_HUMAN Tyrosine-protein kinase JAK1

6g3c[2] I EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/46.8 2
/2 Q506Q0_HUMAN Tyrosine-protein kinase

6g3c[1] J EDO
1,2-ETHANEDIOL[4 atoms] A 0.0
/46.8 1
/1 Q506Q0_HUMAN Tyrosine-protein kinase

6gl9[3] J EDO
1,2-ETHANEDIOL[4 atoms] A 66.7
/51.1 6
/6 JAK3_HUMAN Tyrosine-protein kinase JAK3

6gl9[1] L EDO
1,2-ETHANEDIOL[4 atoms] A 50.0
/51.1 2
/2 JAK3_HUMAN Tyrosine-protein kinase JAK3

6gla[2] G EDO
1,2-ETHANEDIOL[4 atoms] A 88.9
/50.9 9
/9 JAK3_HUMAN Tyrosine-protein kinase JAK3

6gla[1] J EDO
1,2-ETHANEDIOL[4 atoms] A 66.7
/50.9 3
/3 JAK3_HUMAN Tyrosine-protein kinase JAK3

6wtn[2] C EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/51.1 2
/2 JAK2_HUMAN Tyrosine-protein kinase JAK2

6wto[1] C EDO
1,2-ETHANEDIOL[4 atoms] A 33.3
/54.3 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

7apf[1] I EDO
1,2-ETHANEDIOL[4 atoms] A 0.0
/50.9 2
/2 JAK3_HUMAN Tyrosine-protein kinase JAK3

7apf[1] M EDO
1,2-ETHANEDIOL[4 atoms] B 50.0
/51.4 6
/6 JAK3_HUMAN Tyrosine-protein kinase JAK3

7apg[1] U EDO
1,2-ETHANEDIOL[4 atoms] C 33.3
/51.6 3
/3 JAK3_HUMAN Tyrosine-protein kinase JAK3

8g6z[1] E EDO
1,2-ETHANEDIOL[4 atoms] B 66.7
/53.8 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g8o[1] F EDO
1,2-ETHANEDIOL[4 atoms] B 100.0
/52.9 7
/7 JAK2_HUMAN Tyrosine-protein kinase JAK2

8s9a[1] X EDO
1,2-ETHANEDIOL[4 atoms] C 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5c01[2] C UNL
UNKNOWN LIGAND[30 atoms] A 100.0
/100.0 15
/15 TYK2_HUMAN NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2

3nyx[1] C DTT
2,3-DIHYDROXY-1,4-DITHIOBUTANE[8 atoms] A 100.0
/99.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

3nyx[1] D DTT
2,3-DIHYDROXY-1,4-DITHIOBUTANE[8 atoms] A 100.0
/99.0 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

3bce[1] F PEG
DI(HYDROXYETHYL)ETHER[7 atoms] C 14.3
/39.0 7
/7 ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4

3zc6[2] F PEG
DI(HYDROXYETHYL)ETHER[7 atoms] A 66.7
/50.9 3
/3 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

4e5w[2] D PEG
DI(HYDROXYETHYL)ETHER[7 atoms] A 100.0
/58.9 2
/2 JAK1_HUMAN Tyrosine-protein kinase JAK1

5e1e[1] C PEG
DI(HYDROXYETHYL)ETHER[7 atoms] A 25.0
/61.6 4
/4 JAK1_HUMAN Tyrosine-protein kinase JAK1

3zmm[2] D ACE
ACETYL GROUP[3 atoms] A 25.0
/53.7 4
/4 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

3zmm[1] G ACE
ACETYL GROUP[3 atoms] B 66.7
/55.4 3
/3 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

3ugc[1] C MLI
MALONATE ION[7 atoms] A 0.0
/53.8 2
/2 JAK2_HUMAN Tyrosine-protein kinase JAK2

6wtq[1] C TRS
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL[8 atoms] A 33.3
/53.7 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usz[5] E DMS
DIMETHYL SULFOXIDE[4 atoms] A 33.3
/47.2 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

6m9h[1] D DMS
DIMETHYL SULFOXIDE[4 atoms] A 0.0
/47.2 1
/1 JAK2_HUMAN Tyrosine-protein kinase JAK2

8g8o[1] D DMS
DIMETHYL SULFOXIDE[4 atoms] A 0.0
/53.6 2
/2 JAK2_HUMAN Tyrosine-protein kinase JAK2

3bce[1] E PG4
TETRAETHYLENE GLYCOL[13 atoms] C 0.0
/39.0 4
/4 ERBB4_HUMAN Receptor tyrosine-protein kinase erbB-4

3zc6[2] K PG4
TETRAETHYLENE GLYCOL[13 atoms] B 0.0
/51.5 5
/5 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

3zep[8] H GOL
GLYCEROL[6 atoms] C 0.0
/51.1 2
/2 JAK3_HUMAN TYROSINE-PROTEIN KINASE JAK3

4at5[3] C GOL
GLYCEROL[6 atoms] A 0.0
/42.6 6
/7 NTRK2_HUMAN BDNF/NT-3 GROWTH FACTORS RECEPTOR

4e6d[1] E GOL
GLYCEROL[6 atoms] B 85.7
/51.6 7
/7 JAK2_HUMAN Tyrosine-protein kinase JAK2

4fvp[17] B GOL
GLYCEROL[6 atoms] A 57.1
/47.2 7
/7 JAK2_HUMAN Tyrosine-protein kinase JAK2

4fvp[31] C GOL
GLYCEROL[6 atoms] A 100.0
/47.2 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

4gfo[1] F GOL
GLYCEROL[6 atoms] A 100.0
/98.9 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4po6[1] C GOL
GLYCEROL[6 atoms] A 100.0
/100.0 6
/6 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4po6[1] D GOL
GLYCEROL[6 atoms] A 100.0
/100.0 5
/5 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4po6[6] E GOL
GLYCEROL[6 atoms] A 100.0
/100.0 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4ymj[1] J GOL
GLYCEROL[6 atoms] B 50.0
/45.9 6
/6 NTRK3_HUMAN NT-3 growth factor receptor

5c01[5] F GOL
GLYCEROL[6 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2

5c03[1] M GOL
GLYCEROL[6 atoms] B 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5i4n[1] D GOL
GLYCEROL[6 atoms] A 60.0
/46.5 5
/5 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usy[1] G GOL
GLYCEROL[6 atoms] A 33.3
/53.8 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usz[20] D GOL
GLYCEROL[6 atoms] A 66.7
/47.2 3
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut1[3] D GOL
GLYCEROL[6 atoms] A 66.7
/47.2 6
/6 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut6[4] E GOL
GLYCEROL[6 atoms] A 66.7
/47.2 6
/6 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ut6[1] F GOL
GLYCEROL[6 atoms] A 40.0
/47.2 5
/5 JAK2_HUMAN Tyrosine-protein kinase JAK2

6gl9[2] E GOL
GLYCEROL[6 atoms] A 72.7
/51.1 11
/11 JAK3_HUMAN Tyrosine-protein kinase JAK3

6n77[3] D GOL
GLYCEROL[6 atoms] B 75.0
/62.0 4
/4 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n78[5] C GOL
GLYCEROL[6 atoms] A 100.0
/61.9 3
/3 JAK1_HUMAN Tyrosine-protein kinase JAK1

6n7a[1] C GOL
GLYCEROL[6 atoms] A 50.0
/62.3 6
/6 JAK1_HUMAN Tyrosine-protein kinase JAK1

6wtp[1] C GOL
GLYCEROL[6 atoms] A 25.0
/52.2 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

7q7l[1] C GOL
GLYCEROL[6 atoms] A 100.0
/52.8 5
/5 JAK2_HUMAN Tyrosine-protein kinase JAK2

7teu[1] C GOL
GLYCEROL[6 atoms] A 100.0
/53.8 6
/6 JAK2_HUMAN Tyrosine-protein kinase JAK2

8ba2[2] G GOL
GLYCEROL[6 atoms] A 25.0
/46.8 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

5ixd[1] C CIT
CITRIC ACID[13 atoms] A 50.0
/47.2 6
/6 JAK1_HUMAN Tyrosine-protein kinase JAK1

4gl9[1] O PO4
PHOSPHATE ION[5 atoms] B 0.0
/54.0 2
/2 G5E852_MOUSE Tyrosine-protein kinase

6kzd[1] C PO4
PHOSPHATE ION[5 atoms] A 50.0
/46.1 2
/6 NTRK3_HUMAN NT-3 growth factor receptor

4aqc[2] D SO4
SULFATE ION[5 atoms] A 33.3
/51.0 3
/3 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4aqc[10] G SO4
SULFATE ION[5 atoms] B 66.7
/51.4 3
/3 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4aqc[1] H SO4
SULFATE ION[5 atoms] B 40.0
/51.4 5
/5 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4aqc[1] I SO4
SULFATE ION[5 atoms] B 50.0
/51.4 2
/2 JAK2_HUMAN TYROSINE-PROTEIN KINASE JAK2

4gfo[1] B SO4
SULFATE ION[5 atoms] A 100.0
/98.9 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4hzr[2] C SO4
SULFATE ION[5 atoms] A 28.6
/42.4 7
/7 ACK1_HUMAN Activated CDC42 kinase 1

4id7[2] C SO4
SULFATE ION[5 atoms] A 28.6
/42.6 7
/7 ACK1_HUMAN Activated CDC42 kinase 1

4wov[4] D SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4wov[2] E SO4
SULFATE ION[5 atoms] A 100.0
/100.0 7
/7 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

4wov[10] I SO4
SULFATE ION[5 atoms] B 100.0
/100.0 4
/4 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5tkd[5] D SO4
SULFATE ION[5 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5tkd[2] G SO4
SULFATE ION[5 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

5toz[3] C SO4
SULFATE ION[5 atoms] A 100.0
/51.8 1
/1 JAK3_HUMAN Tyrosine-protein kinase JAK3

5ttu[1] D SO4
SULFATE ION[5 atoms] A 100.0
/51.9 5
/5 JAK3_HUMAN Tyrosine-protein kinase JAK3

5usy[2] D SO4
SULFATE ION[5 atoms] A 50.0
/53.8 2
/3 JAK2_HUMAN Tyrosine-protein kinase JAK2

5usy[1] K SO4
SULFATE ION[5 atoms] B 40.0
/53.8 5
/5 JAK2_HUMAN Tyrosine-protein kinase JAK2

6e2p[1] E SO4
SULFATE ION[5 atoms] A 0.0
/36.1 4
/4 JAK2_HUMAN Tyrosine-protein kinase JAK2

6nze[1] E SO4
SULFATE ION[5 atoms] A 100.0
/100.0 2
/2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

6vqm[2] E SO4
SULFATE ION[5 atoms] B 28.6
/42.7 7
/7 ACK1_HUMAN Activated CDC42 kinase 1

7q6h[1] C SO4
SULFATE ION[5 atoms] A 100.0
/51.8 3
/3 JAK3_HUMAN Tyrosine-protein kinase JAK3

7uyu[1] C SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2

7wcx[2] C SO4
SULFATE ION[5 atoms] A 25.0
/41.6 4
/4 FGFR4_HUMAN Fibroblast growth factor receptor 4

7wcx[1] D SO4
SULFATE ION[5 atoms] A 0.0
/41.6 1
/4 FGFR4_HUMAN Fibroblast growth factor receptor 4

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
1187
	pdb_id	a¹	identity[%]²	description
	4oli	A	99.6	TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2
	8ewy	A	51.5	B1ASP2_MOUSE Tyrosine-protein kinase
	4po6	A	100.0	TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

Contact Molecules for Homologous Proteins

Summary Bars[0.0 %]

UniProt Feature Tables [P29597(TYK2_HUMAN)]