HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

2752856

925

131

O95786(RIGI_HUMAN)

RecName: Full=Antiviral innate immune response receptor RIG-I ;AltName: Full=ATP-dependent RNA helicase DDX58 ; EC=3.6.4.13 ;AltName: Full=DEAD box protein 58;AltName: Full=RIG-I-like receptor 1; Short=RLR-1;AltName: Full=RNA sensor RIG-I ;AltName: Full=Retinoic acid-inducible gene 1 protein; Short=RIG-1;AltName: Full=Retinoic acid-inducible gene I protein; Short=RIG-I;

QUERYSEQ

MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMA
GAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI
PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELE
QVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEK
EQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAEMSK

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [O95786(RIGI_HUMAN)]

925
	region	name	description
	1-925	CHAIN	/note="Antiviral innate immune response receptor RIG-I" /id="PRO_0000144093"
	1-87	DOMAIN	/note="CARD 1"
	92-172	DOMAIN	/note="CARD 2"
	251-430	DOMAIN	/note="Helicase ATP-binding"
	610-776	DOMAIN	/note="Helicase C-terminal"
	794-925	DOMAIN	/note="RLR CTR"
	218-925	REGION	/note="Interaction with ZC3HAV1"
	735-925	REGION	/note="Mediates interaction with RNF135"
	264-271	BINDING	/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616"
	810-810	BINDING	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
	813-813	BINDING	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
	864-864	BINDING	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
	869-869	BINDING	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
	1-925	DISORDER	predicted by DISOPRED

MONOMER

925

pdb_id a¹ identity[%]² description

7to0 A 100.0 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

4a2w A 55.7 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

7jl1[4] D RN135_HUMAN E3 ubiquitin-protein ligase RNF135[171 aa] A 100.0
/100.0 10
/10 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl3[2] D RN135_HUMAN E3 ubiquitin-protein ligase RNF135[169 aa] A 100.0
/100.0 1
/1 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[6] B RN135_HUMAN E3 ubiquitin-protein ligase RNF135[178 aa] A 100.0
/100.0 13
/13 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7v[1] B RN135_HUMAN E3 ubiquitin-protein ligase RNF135[178 aa] C 100.0
/100.0 1
/1 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

4nqk[6] E UBC_HUMAN Ubiquitin[72 aa] A 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4nqk[9] J UBC_HUMAN Ubiquitin[73 aa] A 100.0
/100.0 9
/9 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4nqk[5] F UBC_HUMAN Ubiquitin[73 aa] B 100.0
/100.0 11
/11 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[1] Q RL40_HUMAN Ubiquitin-60S ribosomal protein L40[73 aa] H 100.0
/99.5 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[8] I MAVS_HUMAN Mitochondrial antiviral-signaling protein[97 aa] A 100.0
/99.5 11
/11 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[6] I MAVS_HUMAN Mitochondrial antiviral-signaling protein[97 aa] B 100.0
/99.5 6
/6 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[3] I MAVS_HUMAN Mitochondrial antiviral-signaling protein[97 aa] C 100.0
/99.5 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[2] I MAVS_HUMAN Mitochondrial antiviral-signaling protein[97 aa] D 100.0
/99.5 9
/9 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7jl0[4] D TRI65_HUMAN Tripartite motif-containing protein 65[180 aa] C 33.3
/40.2 9
/11 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

NUCLEOTIDE

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

3ncu[2] C 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3' A 100.0
/100.0 13
/13 DDX58_HUMAN RIG-I

3ncu[2] D 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3' A 100.0
/100.0 4
/4 DDX58_HUMAN RIG-I

7bai[4] C RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C).. A 100.0
/100.0 11
/11 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7bai[4] D RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C).. A 100.0
/100.0 3
/3 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

5e3h[1] B RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*U)-3').. A 100.0
/100.0 18
/18 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5e3h[1] C RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*U)-3').. A 100.0
/100.0 27
/27 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[12] B RNA (5'-R(P*GP*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP.. A 100.0
/100.0 40
/40 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[6] B RNA (5'-R(P*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP*AP.. A 100.0
/100.0 37
/37 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6kyv[6] A RNA (5'-R(*GP*GP*UP*AP*GP*AP*CP*GP*CP*UP*UP*CP*GP*.. B 100.0
/100.0 46
/46 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7bah[2] C RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3').. A 100.0
/100.0 11
/11 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7bah[2] D RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3').. A 100.0
/100.0 3
/3 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl0[1] A RNA (5'-R(P*GP*AP*CP*UP*GP*AP*CP*UP*GP*AP*CP*UP*GP.. C 60.0
/40.2 10
/11 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl1[1] B dsRNA strand 1 A 100.0
/100.0 17
/17 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl0[1] B RNA (5'-R(P*UP*CP*AP*GP*UP*CP*AP*GP*UP*CP*AP*GP*UP.. C 71.4
/40.2 21
/21 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl1[1] C dsRNA strand 2 A 100.0
/100.0 27
/27 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl3[3] G dsRNA strand1 A 100.0
/100.0 14
/14 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl3[3] H dsRNA strand 2 A 100.0
/100.0 24
/24 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7mk1[2] C DNA (41-MER) A 100.0
/100.0 17
/17 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7tnx[1] B p3dsRNAa A 100.0
/100.0 24
/24 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7tnx[1] C p3dsRNAb A 100.0
/100.0 21
/21 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7tny[2] B p2dsRNA A 100.0
/100.0 26
/26 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7tny[2] C p2dsRNA A 100.0
/100.0 29
/29 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to0[1] B OHdsRNA A 100.0
/100.0 27
/27 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to0[1] C OHdsRNA A 100.0
/100.0 28
/28 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to1[1] B p3SLR30 A 100.0
/100.0 41
/41 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to2[1] B p3SLR30 A 100.0
/100.0 57
/57 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8dvr[1] B p3SLR30 A 100.0
/100.0 33
/33 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8dvs[1] B OHSLR30 A 100.0
/100.0 48
/48 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8dvu[1] B OHSLR30 A 100.0
/100.0 55
/55 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[2] E p3dsRNA24a A 100.0
/100.0 22
/22 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[2] E p3dsRNA24a C 100.0
/100.0 21
/21 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[2] F p3dsRNA24b A 100.0
/100.0 24
/24 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[2] F p3dsRNA24b C 100.0
/100.0 16
/16 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7v[2] E p3dsRNA24a A 100.0
/100.0 21
/21 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7v[2] F p3dsRNA24b A 100.0
/100.0 19
/19 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8scz[1] B p3SLR30 A 100.0
/100.0 42
/42 RIGI_HUMAN Antiviral innate immune response receptor RIG-I

8sd0[1] B p3SLR14 A 100.0
/100.0 39
/39 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

6gpg[1] A RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*.. C 100.0
/99.8 19
/19 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6gpg[1] B RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*.. C 100.0
/99.8 29
/29 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4ay2[1] B 5'-R-PPP(GP*GP*CP*GP*CP*GP*GP*CP*UP*UP*CP*GP*GP*CP.. A 100.0
/99.7 31
/31 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

2ykg[4] B 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' A 100.0
/99.5 16
/16 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

2ykg[4] C 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' A 100.0
/99.5 16
/16 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

3og8[2] C RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*.. A 90.9
/99.2 11
/11 RIGI_HUMAN Antiviral innate immune response receptor RIG-I

3og8[2] D RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*.. A 100.0
/99.2 4
/4 RIGI_HUMAN Antiviral innate immune response receptor RIG-I

3lrn[2] C RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP.. A 93.3
/99.2 15
/15 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

3lrn[2] D RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP.. A 100.0
/99.2 3
/3 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

3lrr[2] C RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U).. A 93.3
/99.2 15
/15 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

3lrr[2] D RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U).. A 100.0
/99.2 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4a36[1] C 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *U.. A 28.6
/60.0 7
/7 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a36[1] D 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *C.. A 70.8
/60.0 24
/24 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a36[1] E 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *U.. B 28.6
/59.7 7
/7 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a36[1] F 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *C.. B 72.0
/59.7 25
/25 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a2x[2] E 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3.. A 88.9
/55.3 9
/9 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a2x[2] E 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3.. B 100.0
/55.3 1
/1 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a2x[2] F 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3.. A 0.0
/55.3 2
/2 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a2x[2] F 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3.. B 88.9
/55.3 9
/9 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4gl2[2] C RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3').. A 46.2
/41.4 13
/14 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

4gl2[2] F RNA (5'-R(P*AP*GP*GP*GP*CP*CP*GP*CP*GP*GP*AP*U)-3'.. A 58.6
/41.4 29
/29 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl2[3] A RNA (44-MER) C 53.8
/40.2 13
/14 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl2[3] B RNA (44-MER) C 57.1
/40.2 21
/21 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

3zd7[2] F ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 100.0
/99.4 14
/14 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

4a36[3] G ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 78.6
/60.0 14
/15 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

7jl0[4] F ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] C 80.0
/40.2 10
/11 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl1[4] E ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 100.0
/100.0 10
/10 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to2[3] E ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] A 100.0
/100.0 12
/12 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

5f98[6] O M7G
7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE[29 atoms.. A 100.0
/100.0 7
/7 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[6] Q GTP
GUANOSINE-5'-TRIPHOSPHATE[32 atoms] A 100.0
/100.0 10
/10 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

8dvr[1] D GTP
GUANOSINE-5'-TRIPHOSPHATE[32 atoms] A 100.0
/100.0 10
/10 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

3tbk[3] B ANP
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER[31 ato.. A 91.7
/78.8 12
/12 DDX58_MOUSE RIG-I Helicase Domain

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

METAL

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

2qfb[10] K ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

2ykg[3] D ZN
ZINC ION[1 atoms] A 100.0
/99.5 4
/4 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

3lrn[4] E ZN
ZINC ION[1 atoms] A 100.0
/99.2 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

3ncu[2] E ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN RIG-I

3og8[9] E ZN
ZINC ION[1 atoms] A 100.0
/99.2 4
/4 RIGI_HUMAN Antiviral innate immune response receptor RIG-I

4ay2[7] C ZN
ZINC ION[1 atoms] A 100.0
/99.7 4
/4 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

4bpb[1] D ZN
ZINC ION[1 atoms] A 100.0
/99.5 4
/4 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

4gl2[2] H ZN
ZINC ION[1 atoms] A 80.0
/41.4 5
/5 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

5e3h[19] D ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6gpg[1] D ZN
ZINC ION[1 atoms] C 100.0
/99.8 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7bah[10] E ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl0[4] E ZN
ZINC ION[1 atoms] C 100.0
/40.2 4
/4 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl1[4] H ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7tnx[16] D ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8scz[1] C ZN
ZINC ION[1 atoms] A 100.0
/100.0 4
/4 RIGI_HUMAN Antiviral innate immune response receptor RIG-I

2qfd[10] K HG
MERCURY (II) ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

3zd7[1] E MG
MAGNESIUM ION[1 atoms] A 100.0
/99.4 2
/2 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

4a36[2] H MG
MAGNESIUM ION[1 atoms] A 100.0
/60.0 5
/5 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4ay2[1] E MG
MAGNESIUM ION[1 atoms] A 100.0
/99.7 3
/3 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

5e3h[5] E MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5e3h[1] F MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5e3h[2] G MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] N MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[4] N MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[2] N MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[1] O MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[1] P MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[1] U MG
MAGNESIUM ION[1 atoms] E 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9h[1] X MG
MAGNESIUM ION[1 atoms] G 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6gpg[4] E MG
MAGNESIUM ION[1 atoms] C 100.0
/99.8 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7jl0[1] H MG
MAGNESIUM ION[1 atoms] C 100.0
/40.2 1
/1 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7mk1[2] F MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 1
/1 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7to2[3] D MG
MAGNESIUM ION[1 atoms] A 100.0
/100.0 2
/2 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

4on9[1] G CL
CHLORIDE ION[1 atoms] B 100.0
/100.0 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6bzh[1] G CL
CHLORIDE ION[1 atoms] A 66.7
/76.5 3
/3 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[1] H CL
CHLORIDE ION[1 atoms] A 100.0
/76.5 1
/1 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[1] L CL
CHLORIDE ION[1 atoms] D 0.0
/76.5 3
/3 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

3b6e[1] B NA
SODIUM ION[1 atoms] A 100.0
/51.0 5
/5 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4on9[2] B DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[495 aa] A 100.0
/100.0 40
/40 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[18] C DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[648 aa] A 100.0
/100.0 20
/20 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] E DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[641 aa] A 100.0
/100.0 26
/26 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] G DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[647 aa] A 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] K DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[644 aa] A 100.0
/100.0 3
/3 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] G DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[647 aa] C 100.0
/100.0 11
/11 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f98[6] K DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[644 aa] C 100.0
/100.0 3
/3 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7jl3[2] C DDX58_HUMAN Antiviral innate immune response receptor RIG-I[65.. A 100.0
/100.0 7
/7 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

7jl3[2] E DDX58_HUMAN Antiviral innate immune response receptor RIG-I[65.. A 100.0
/100.0 6
/6 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7t[4] C DDX58_HUMAN Antiviral innate immune response receptor RIG-I[61.. A 100.0
/100.0 10
/10 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7u[1] A DDX58_HUMAN Antiviral innate immune response receptor RIG-I[64.. C 100.0
/100.0 10
/10 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

8g7v[1] A DDX58_HUMAN Antiviral innate immune response receptor RIG-I[64.. C 100.0
/100.0 9
/9 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

4nqk[18] B DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[188 aa] A 100.0
/100.0 21
/21 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4nqk[12] D DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[188 aa] A 100.0
/100.0 12
/12 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[2] E DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[188 aa] A 100.0
/99.5 3
/3 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4p4h[8] H DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58[188 aa] A 100.0
/99.5 2
/2 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

6bzh[4] C DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58[191 aa] A 82.4
/76.5 17
/17 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[4] D DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58[189 aa] A 72.7
/76.5 22
/22 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

7jl2[2] E IFIH1_HUMAN Interferon-induced helicase C domain-containing pr.. C 0.0
/40.2 9
/9 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl2[2] G IFIH1_HUMAN Interferon-induced helicase C domain-containing pr.. C 0.0
/40.2 7
/9 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

925 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

2ykg[2] E SO4
SULFATE ION[5 atoms] A 100.0
/99.5 7
/7 DDX58_HUMAN PROBABLE ATP-DEPENDENT RNA HELICASE DDX58

4on9[2] C SO4
SULFATE ION[5 atoms] A 100.0
/100.0 7
/7 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4on9[2] D SO4
SULFATE ION[5 atoms] A 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4on9[2] E SO4
SULFATE ION[5 atoms] A 100.0
/100.0 1
/1 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

4a2v[1] C GOL
GLYCEROL[6 atoms] A 66.7
/55.3 6
/8 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

4a2v[1] D GOL
GLYCEROL[6 atoms] A 66.7
/55.3 3
/3 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

5e3h[1] H GOL
GLYCEROL[6 atoms] A 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5e3h[1] J BEF
BERYLLIUM TRIFLUORIDE ION[4 atoms] A 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] O ETF
TRIFLUOROETHANOL[6 atoms] A 100.0
/100.0 9
/9 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] Y ETF
TRIFLUOROETHANOL[6 atoms] E 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[2] CA ETF
TRIFLUOROETHANOL[6 atoms] G 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] NA ETF
TRIFLUOROETHANOL[6 atoms] K 100.0
/100.0 6
/6 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] P BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] A 100.0
/100.0 7
/7 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] Q BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] A 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[2] U BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] A 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] T BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] C 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] V BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] C 100.0
/100.0 4
/4 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[5] W BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] C 100.0
/100.0 8
/8 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[2] AA BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] E 100.0
/100.0 9
/9 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

5f9f[1] EA BU3
(R,R)-2,3-BUTANEDIOL[6 atoms] G 100.0
/100.0 5
/5 DDX58_HUMAN Probable ATP-dependent RNA helicase DDX58

7jl0[4] G ALF
TETRAFLUOROALUMINATE ION[5 atoms] C 100.0
/40.2 6
/6 IFIH1_HUMAN Interferon-induced helicase C domain-containing pr..

7jl1[4] F ALF
TETRAFLUOROALUMINATE ION[5 atoms] A 100.0
/100.0 5
/5 DDX58_HUMAN Antiviral innate immune response receptor RIG-I

3tbk[1] C EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/78.8 7
/7 DDX58_MOUSE RIG-I Helicase Domain

6bzh[2] F EDO
1,2-ETHANEDIOL[4 atoms] A 100.0
/76.5 2
/2 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[1] I EDO
1,2-ETHANEDIOL[4 atoms] B 100.0
/76.5 1
/3 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[1] J EDO
1,2-ETHANEDIOL[4 atoms] B 100.0
/76.5 2
/2 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

6bzh[1] J EDO
1,2-ETHANEDIOL[4 atoms] C 75.0
/76.1 4
/4 DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58

4a36[2] I AF3
ALUMINUM FLUORIDE[4 atoms] A 100.0
/60.0 9
/9 D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
925
	pdb_id	a¹	identity[%]²	description
	7to0	A	100.0	DDX58_HUMAN Antiviral innate immune response receptor RIG-I
	4a2w	A	55.7	D3TI84_ANAPL RETINOIC ACID INDUCIBLE PROTEIN I
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

Contact Molecules for Homologous Proteins

Summary Bars[40 %]

UniProt Feature Tables [O95786(RIGI_HUMAN)]