Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
30181 425 91 P84022(SMAD3_HUMAN) RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3;
QUERYSEQ 
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEF
PPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ] 
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
1M---- 
MIVL
 INIT_MET /note="Removed" ECO:0007744|PubMed:22814378" INIT_MET /note="Removed" ECO:0007744|PubMed:22814378" DISORDER predicted by DISOPRED
2S---- 
SNTGA
 MOD_RES /note="N-acetylserine" ECO:0007744|PubMed:22814378" MOD_RES /note="N-acetylserine" ECO:0007744|PubMed:22814378" DISORDER predicted by DISOPRED
3S---- 
SG
 DISORDER predicted by DISOPRED
4I---- 
LI
 DISORDER predicted by DISOPRED
5L---- 
FL
 DISORDER predicted by DISOPRED
6P---- 
SPH
 DISORDER predicted by DISOPRED
7F e125.4 1ozj_C 
FM
 DISORDER predicted by DISOPRED
8T e 30.5 1ozj_C homo 
TH
 MOD_RES /note="Phosphothreonine; by CDK2 and CDK4" MUTAGEN /note="T->V: Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213." MOD_RES /note="Phosphothreonine; by CDK2 and CDK4" MUTAGEN /note="T->V: Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213." DISORDER predicted by DISOPRED
9P e 40.3 1ozj_C homo 
SPG
 DISORDER predicted by DISOPRED
10PHe 75.2 1ozj_C 
P
 DOMAIN /note="MH1" DOMAIN /note="MH1"
11IHb 13.5 1ozj_C homo 
AIV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
12VHb 0.7 1ozj_C homo 
V
 DOMAIN /note="MH1" DOMAIN /note="MH1"
13KHe 50.5 1ozj_C 
KH
 DOMAIN /note="MH1" DOMAIN /note="MH1"
14RHe 42.3 1ozj_C homo 
RSK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
15LHb 0.6 1ozj_C homo 
L
 DOMAIN /note="MH1" DOMAIN /note="MH1"
16LHb 5.6 1ozj_C homo precipitant 
LM
 DOMAIN /note="MH1" DOMAIN /note="MH1"
17GTe 72.6 1ozj_C precipitant 
GCK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
18WSe 44.6 1ozj_C homo precipitant 
WH
 DOMAIN /note="MH1" DOMAIN /note="MH1"
19K e 31.1 1ozj_C homo precipitant 
KR
 DOMAIN /note="MH1" DOMAIN /note="MH1"
20K e 34.4 1ozj_C homo precipitant 
QKI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
21G b 14.3 1ozj_C homo precipitant 
GS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
22ESe 62.3 1ozj_C metal CL homo 
DEQAFGIKLNPRSTVY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
23Q e 49.5 1ozj_C metal CL precipitant 
EQKDAGILPRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
24N e 63.6 1ozj_C metal CL 
NGLAESVDIKPRTFQYCHMW
 DOMAIN /note="MH1" DOMAIN /note="MH1"
25GHe 60.7 1ozj_C metal CL 
GNALEKSTVDFIPQRCHMWY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
26QHe 79.6 1ozj_C metal CL 
EIQALGKSTVDFNPRCHMWY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
27EHe 31.2 1ozj_C metal CL precipitant 
EDS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
28EHe 25.1 1ozj_C homo precipitant 
ERS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
29KHe 37.7 1ozj_C 
KQETRDN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
30WHb 10.4 1ozj_C precipitant 
WFE
 DOMAIN /note="MH1" DOMAIN /note="MH1"
31CHb 5.3 1ozj_C homo 
ALCDV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
32EHb 18.1 1ozj_C homo 
KELQR
 DOMAIN /note="MH1" DOMAIN /note="MH1"
33KHe 39.6 1ozj_C nucleotide precipitant 
KTRA
 CROSSLNK /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" MUTAGEN /note="K->R: Slightly decreased monoubiquitination." DOMAIN /note="MH1" CROSSLNK /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" MUTAGEN /note="K->R: Slightly decreased monoubiquitination." DOMAIN /note="MH1"
34AHb 0.0 1ozj_C 
AV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
35VHb 0.0 1ozj_C homo 
TVIC
 DOMAIN /note="MH1" DOMAIN /note="MH1"
36KHe 31.1 1ozj_C homo 
EDYRK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
37SHe 21.9 1ozj_C nucleotide 
SALN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
38LHb 1.1 1ozj_C 
LV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
39VHb 3.3 1ozj_C homo 
VLSM
 DOMAIN /note="MH1" DOMAIN /note="MH1"
40KHe 56.1 1ozj_C nucleotide 
KR
 SITE /note="Required for trimerization" MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44." DOMAIN /note="MH1" SITE /note="Required for trimerization" MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44." DOMAIN /note="MH1"
41KHe 28.3 1ozj_C nucleotide metal CL 
KRV
 SITE /note="Required for interaction with DNA and JUN and for functional cooperation with JUN" MUTAGEN /note="K->A: Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43." DOMAIN /note="MH1" SITE /note="Required for interaction with DNA and JUN and for functional cooperation with JUN" MUTAGEN /note="K->A: Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43." DOMAIN /note="MH1"
42LHb 0.0 1ozj_C 
LA
 DOMAIN /note="MH1" DOMAIN /note="MH1"
43KHe 58.5 1ozj_C homo 
KI
 MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44." DOMAIN /note="MH1" MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44." DOMAIN /note="MH1"
44KHe 78.8 1ozj_C 
KED
 MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43." DOMAIN /note="MH1" MUTAGEN /note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43." DOMAIN /note="MH1"
45TTe 53.9 1ozj_C 
KRHT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
46GTe 76.2 1ozj_C precipitant 
GKQSINALDEFPRTVY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
47Q b 17.9 1ozj_C homo precipitant 
AQCSDNLEKTR
 DOMAIN /note="MH1" DOMAIN /note="MH1"
48LHb 11.8 1ozj_C homo precipitant 
LFMEDHI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
49DHe 75.9 1ozj_C 
EDLS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
50EHe 21.1 1ozj_C precipitant 
EALTSDQN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
51LHb 1.1 1ozj_C homo 
LFI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
52EHe 25.1 1ozj_C homo 
ELIYDQ
 DOMAIN /note="MH1" DOMAIN /note="MH1"
53KHe 42.5 1ozj_C 
KTDEQRVAFC
 MUTAGEN /note="K->R: Slightly decreased monoubiquitination." DOMAIN /note="MH1" MUTAGEN /note="K->R: Slightly decreased monoubiquitination." DOMAIN /note="MH1"
54AHb 0.0 1ozj_C 
AV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
55IHb 1.2 1ozj_C homo 
VLIE
 DOMAIN /note="MH1" DOMAIN /note="MH1"
56THe 26.0 1ozj_C homo 
STEIRA
 DOMAIN /note="MH1" DOMAIN /note="MH1"
57THe 47.4 1ozj_C 
SKCTRN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
58Q e 51.0 1ozj_C homo 
GPRNQ
 DOMAIN /note="MH1" DOMAIN /note="MH1"
59N e 36.4 1ozj_C 
GDNTQC
 DOMAIN /note="MH1" DOMAIN /note="MH1"
60VTe 30.7 1ozj_C 
QTKPVACI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
61NTe 77.0 1ozj_C 
PKNRHYQ
 DOMAIN /note="MH1" DOMAIN /note="MH1"
62TSb 3.2 1ozj_C 
TSG
 DOMAIN /note="MH1" DOMAIN /note="MH1"
63K e 72.6 1ozj_C homo precipitant 
GKRAEN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
64C b 10.7 1ozj_C metal ZN CL homo precipitant 
C
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1"
65I b 0.0 1ozj_C precipitant 
VICL
 DOMAIN /note="MH1" DOMAIN /note="MH1"
66TEb 7.8 1ozj_C precipitant 
TLP
 DOMAIN /note="MH1" DOMAIN /note="MH1"
67IEb 4.1 1ozj_C metal CL 
IVLADEFGKNPQRST
 DOMAIN /note="MH1" DOMAIN /note="MH1"
68PEe 64.3 1ozj_C metal CL 
PQADEFGIKLNRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
69R e 26.5 1ozj_C 
RGKADEFILNPQSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
70S e 39.1 1ozj_C nucleotide 
SATRGL
 DOMAIN /note="MH1" DOMAIN /note="MH1"
71LTe102.2 1ozj_C nucleotide 
LHADEFGIKNPQRSTVY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
72DTe 54.9 1ozj_C nucleotide 
DNLAEFGIKPQRSTVY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
73GSb 3.6 1ozj_C 
GECADIKLPRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
74R e 47.8 1ozj_C nucleotide 
RKDE
 MUTAGEN /note="R->D: Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN." DOMAIN /note="MH1" MUTAGEN /note="R->D: Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN." DOMAIN /note="MH1"
75LEb 11.8 1ozj_C nucleotide 
L
 DOMAIN /note="MH1" DOMAIN /note="MH1"
76QEe 50.5 1ozj_C nucleotide 
QRI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
77VEb 3.3 1ozj_C nucleotide 
VLGPI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
78STe 50.8 1ozj_C nucleotide precipitant 
SANGPH
 DOMAIN /note="MH1" DOMAIN /note="MH1"
79HTe 91.6 1ozj_C nucleotide homo precipitant 
HGFSA
 DOMAIN /note="MH1" DOMAIN /note="MH1"
80REe 39.9 1ozj_C metal CL homo precipitant 
RGQSK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
81KEe 46.2 1ozj_C nucleotide homo precipitant 
KRPY
 CROSSLNK /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" MUTAGEN /note="K->R: Decreased monoubiquitination." DOMAIN /note="MH1" CROSSLNK /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" MUTAGEN /note="K->R: Decreased monoubiquitination." DOMAIN /note="MH1"
82GEe 22.6 1ozj_C precipitant 
GASP
 DOMAIN /note="MH1" DOMAIN /note="MH1"
83L b 19.7 1ozj_C nucleotide 
LPFIV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
84PHb 5.4 1ozj_C 
PM
 DOMAIN /note="MH1" DOMAIN /note="MH1"
85HHb 1.6 1ozj_C 
HCQADEGIKLPRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
86VHb 5.3 1ozj_C 
VL
 DOMAIN /note="MH1" DOMAIN /note="MH1"
87IHb 5.3 1ozj_C 
ILV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
88YHb 0.9 1ozj_C 
YLADEFGIKNPQRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
89CHb 0.0 1ozj_C 
CGADEFIKLNPQRSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
90RHe 31.2 1ozj_C precipitant 
RK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
91LHb 4.5 1ozj_C metal CL homo 
LVAI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
92WHb 4.8 1ozj_C homo 
WFY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
93RTe 24.1 1ozj_C homo 
R
 DOMAIN /note="MH1" DOMAIN /note="MH1"
94W b 18.7 1ozj_C homo 
WF
 DOMAIN /note="MH1" DOMAIN /note="MH1"
95PTe 49.6 1ozj_C homo 
PN
 DOMAIN /note="MH1" DOMAIN /note="MH1"
96DTe 71.0 1ozj_C homo 
DVEK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
97L b 2.8 1ozj_C homo 
LIMV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
98H e 74.9 1ozj_C homo 
QRHSADEFGIKLNPTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
99SSe 29.7 1ozj_C nucleotide 
SHYKT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
100HGe 31.9 1ozj_C nucleotide 
HEKPASGLTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
101HGe 62.3 1ozj_C nucleotide 
HSNVA
 DOMAIN /note="MH1" DOMAIN /note="MH1"
102EGe 20.6 1ozj_C 
EQ
 DOMAIN /note="MH1" DOMAIN /note="MH1"
103LEb 6.7 1ozj_C 
LVT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
104REe 69.2 1ozj_C 
KRV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
105AEe 25.9 1ozj_C metal CL 
APSHRK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
106M e 21.3 1ozj_C 
LIVM
 DOMAIN /note="MH1" DOMAIN /note="MH1"
107ETe 90.5 1ozj_C 
ECDLKV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
108LTe 46.1 1ozj_C homo 
TCGYHEDQLMNIV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
109C b 4.7 1ozj_C metal ZN 
C
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1"
110ETe 59.3 1ozj_C metal ZN homo 
EQRSK
 DOMAIN /note="MH1" DOMAIN /note="MH1"
111FTe 24.9 1ozj_C homo precipitant 
FYHST
 DOMAIN /note="MH1" DOMAIN /note="MH1"
112A b 1.8 1ozj_C metal CL 
APYFCST
 DOMAIN /note="MH1" DOMAIN /note="MH1" A->V:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795]
113FGb 10.5 1ozj_C metal CL 
FGYAS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
114NGe 68.5 1ozj_C metal CL 
NADEGKS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
115MGe 41.5 1ozj_C 
SAMLI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
116K e 75.5 1ozj_C precipitant 
KHDNG
 DOMAIN /note="MH1" DOMAIN /note="MH1"
117K e 43.9 1ozj_C homo 
QSGPCKT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
118DSe 85.8 1ozj_C homo 
DKPREM
 DOMAIN /note="MH1" DOMAIN /note="MH1"
119EEe 32.7 1ozj_C homo precipitant 
ENTLSDMY
 DOMAIN /note="MH1" DOMAIN /note="MH1"
120VEb 1.3 1ozj_C 
VI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
121CEb 0.0 1ozj_C metal ZN 
C
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1"
122V b 2.0 1ozj_C 
ICVL
 DOMAIN /note="MH1" DOMAIN /note="MH1"
123N b 0.0 1ozj_C metal ZN 
N
 DOMAIN /note="MH1" DOMAIN /note="MH1"
124PGb 0.8 1ozj_C 
P
 DOMAIN /note="MH1" DOMAIN /note="MH1"
125YGb 10.4 1ozj_C 
YH
 DOMAIN /note="MH1" DOMAIN /note="MH1"
126HGb 1.0 1ozj_C metal ZN 
H
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" DOMAIN /note="MH1"
127YEb 3.5 1ozj_C metal CL 
YFL
 DOMAIN /note="MH1" DOMAIN /note="MH1"
128QEe 54.6 1ozj_C 
SERKQ
 DOMAIN /note="MH1" DOMAIN /note="MH1"
129REe 28.1 1ozj_C homo 
RWI
 DOMAIN /note="MH1" DOMAIN /note="MH1"
130V e 28.0 1ozj_C homo 
VLADEGIKPRST
 DOMAIN /note="MH1" DOMAIN /note="MH1"
131E e 85.4 1ozj_C homo 
ECVDHSAGIKLPRT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
132T e 97.4 1ozj_C homo 
STGLNRADEIKPV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
133P e 55.8 5odg_A 
PRGNADEIKLSTV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
134V e 96.0 5odg_A homo 
VETDGRAFIKLNPQS
 DOMAIN /note="MH1" DOMAIN /note="MH1"
135L e117.4 5odg_A 
LSIVMADEFGKNPQRT
 DOMAIN /note="MH1" DOMAIN /note="MH1"
136P---- 
PDTAEFGIKLNQRSV
 DOMAIN /note="MH1" DOMAIN /note="MH1"
137P---- 
PLSADEFGIKNQRTV
 REGION /note="Linker" REGION /note="Linker"
138V---- 
VIPSARGLDEFKMNQTY
 REGION /note="Linker" REGION /note="Linker"
139L---- 
LIGHDPAEKNQRSTV
 REGION /note="Linker" REGION /note="Linker"
140V---- 
VQCLSYAG
 REGION /note="Linker" REGION /note="Linker"
141P---- 
PSETRGALDFIKNQVY
 REGION /note="Linker" REGION /note="Linker"
142R---- 
RLYAGDEFIKNPQSTV
 REGION /note="Linker" REGION /note="Linker"
143H---- 
HNEQDLYAGS
 REGION /note="Linker" REGION /note="Linker"
144T---- 
STKVNADEGILPQR
 REGION /note="Linker" REGION /note="Linker"
145E---- 
EPNSAGLDFIKQRTVY
 REGION /note="Linker" REGION /note="Linker"
146I---- 
LPAISKFMYEGTVCDHNQR
 REGION /note="Linker" REGION /note="Linker"
147P---- 
PDLNAEGIKQRSTV
 REGION /note="Linker" REGION /note="Linker"
148A---- 
PAYSGMDVTEIKLNQR
 REGION /note="Linker" REGION /note="Linker"
149E---- 
GQKEYRSPAL
 REGION /note="Linker" REGION /note="Linker"
150F---- 
FSEQYLMHAG
 REGION /note="Linker" REGION /note="Linker"
151P---- 
PRKSDEQLM
 REGION /note="Linker" REGION /note="Linker"
152P---- 
PYLVNIM
 REGION /note="Linker" REGION /note="Linker"
153L---- 
LIPKVMADEGNQRST
 REGION /note="Linker" REGION /note="Linker"
154D---- 
DGMESAQHFIKLNPRTV
 REGION /note="Linker" REGION /note="Linker"
155D---- 
DTEMHKQLAFGINPRSVY
 REGION /note="Linker" REGION /note="Linker"
156Y---- 
YFLMNSTADEGIKPQRV
 REGION /note="Linker" REGION /note="Linker"
157S---- 
SEVGRTNALDFHIKMPQY
 REGION /note="Linker" REGION /note="Linker"
158H---- 
HRYPSAEGLVDFIKMNQT
 REGION /note="Linker" REGION /note="Linker"
159S---- 
STDFLHRPAEGIKNQVY
 REGION /note="Linker" REGION /note="Linker"
160I---- 
MISEFLADGKNPQRTVY
 REGION /note="Linker" REGION /note="Linker"
161P---- 
PTELADFGIKNQRSVY
 REGION /note="Linker" REGION /note="Linker"
162E---- 
ENQGHLAKSTVCDFIMPRY
 REGION /note="Linker" REGION /note="Linker"
163N---- 
NADQTLEGKSVCFHIMPRY
 REGION /note="Linker" REGION /note="Linker"
164T---- 
TAVEIPLGKSCDFHMNQRY
 REGION /note="Linker" REGION /note="Linker"
165N---- 
NTSQWLAEGKVCDFHIMPRY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
166F---- 
FKLYQMAEGSVDINPRTCHW
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
167P---- 
PSAGLDEIKNQRTVCFHMY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
168A---- 
ADSLEGFIKNPQRTVY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
169G---- 
SGNLADEIKPRTVCFHMQY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
170I---- 
IFVLSADEGKNPQRTY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker" I->V:(13.0 %):LB/B - dbSNP:rs3587446
171E---- 
QNEKRDSPHALFGITVY
 REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker"
172P---- 
PSQTFAEGLVDHIKMNRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
173Q---- 
NQTCAPHLDEFGIKRSVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
174S---- 
SAMPNLDEFGIKQRTVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
175N---- 
NDHCALGQSEFIKPRTVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
176I---- 
CAITLQWSMYDEFGKNPRV
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
177P---- 
PRSFALDEGIKNQTVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
178E---- 
DEPNSHAGLFIKQRTVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
179T---- 
TQPASLDEFGIKNRVY
 MOD_RES /note="Phosphothreonine; by CDK2, CDK4 and MAPK" ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="T->V: Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" REGION /note="Disordered" REGION /note="Linker" MOD_RES /note="Phosphothreonine; by CDK2, CDK4 and MAPK" ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="T->V: Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
180P---- 
PVSYALDEFGIKNQRT
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
181P---- 
PMSNALDEFGIKQRTVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
182P---- 
PSAGLDEIKNQRTVCFHMWY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
183G---- 
AGSQNVEKLTCDFHIMPRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
184Y---- 
YLQFGSHAEKTVCDIMNPR
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
185L---- 
ILSMPVAEGKTCDFHNQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
186S---- 
PSETFAGKLVCDHIMNQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
187E---- 
EAPSDGKLTVCFHIMNQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
188D---- 
DPVGEQALSFHIKMNRTY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
189G---- 
GLPEDAIKRSTVCFHMNQY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
190E---- 
ESAMNQLDGKPTVCFHIRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
191T---- 
TSFDVPMQALEGIKNRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
192S---- 
SQFAYMLDEGIKNPRTV
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
193D---- 
DATPVQGEIKLNRS
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
194H---- 
HAELNCQDFGIKPRSTV
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
195Q---- 
SPQNTDAEFGIKLRV
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
196M---- 
MLFGYVQTAESDHIKNPR
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
197N---- 
NSPDTLAEGKVCFHIMQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
198H---- 
HQEGTMNPYLADKSVCFIR
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
199S---- 
SPQGTADLEKVCFHIMNRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
200M---- 
MAETFQHNLDGKPSVCIRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
201D---- 
DAPEKSNLGTVCFHIMQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
202A---- 
TGPAHFLDEIKNQRSVY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
203G---- 
GNDLSAEKTVCFHIMPQRY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
204S---- 
SPTIQAEGKLVCDFHMNRY
 MOD_RES /note="Phosphoserine; by GSK3 and MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" REGION /note="Disordered" REGION /note="Linker" MOD_RES /note="Phosphoserine; by GSK3 and MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
205P---- 
PGNEALDIKRSTVCFHMQY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
206N---- 
NQVYSPETALDFGIKR
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
207L---- 
LSVGMEQADFIKNPRTY
 REGION /note="Disordered" REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
208S---- 
SAHTVLIMDEFGKNPQRY
 MOD_RES /note="Phosphoserine; by MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" REGION /note="Disordered" REGION /note="Linker" MOD_RES /note="Phosphoserine; by MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" MUTAGEN /note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245" DISORDER predicted by DISOPRED REGION /note="Disordered" REGION /note="Linker"
209P---- 
PDGALEFIKNQRSTVY
 REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Linker"
210N---- 
GDQTYNAPSLEFIKRV
 REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Linker"
211P---- 
PAGSECTQNDFIKLRVY
 REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Linker"
212M---- 
LMVTIFADEGKNPRS
 REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Linker"
213S---- 
SKATPVDEGFILNQR
 MOD_RES /note="Phosphoserine; by CDK2 and CDK4" ECO:0000269|PubMed:15241418" MUTAGEN /note="S->A: Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179." REGION /note="Linker" MOD_RES /note="Phosphoserine; by CDK2 and CDK4" ECO:0000269|PubMed:15241418" MUTAGEN /note="S->A: Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179." REGION /note="Linker"
214P---- 
PADSRLEGKTVCFHIMNQY
 REGION /note="Linker" REGION /note="Linker"
215A---- 
TAISVEFGLDHKMNPQRY
 REGION /note="Linker" DISORDER predicted by DISOPRED REGION /note="Linker"
216H---- 
HIDSAYNEGKLPQRTV
 REGION /note="Linker" REGION /note="Linker"
217N---- 
NSTYDQKHALEFGIPRV
 REGION /note="Linker" REGION /note="Linker"
218N---- 
SRNPQDEHAGLVFIKMTY
 REGION /note="Linker" REGION /note="Linker"
219L---- hetero ZFYV9_HUMAN 
LGIPTSRAEVDFHKMNQY
 REGION /note="Linker" REGION /note="Linker"
220D e125.9 1mk2_A hetero ZFYV9_HUMAN 
DLNAEFGIKPQRSTVY
 REGION /note="Linker" REGION /note="Linker"
221L e 77.5 1mk2_A hetero ZFYV9_HUMAN 
VLFMAPDEGIKNQRSTY
 REGION /note="Linker" REGION /note="Linker"
222Q e 67.9 1mk2_A hetero ZFYV9_HUMAN homo 
QENRAHLDFGIKPSTVY
 REGION /note="Linker" REGION /note="Linker"
223P e 78.3 1mk2_A hetero ZFYV9_HUMAN 
PQALDEFGIKNRSTVY
 REGION /note="Linker" REGION /note="Linker"
224V e 26.7 1mk2_A hetero ZFYV9_HUMAN homo 
GIKPVLADEFNQRSTY
 REGION /note="Linker" REGION /note="Linker"
225T e 69.5 1mk2_A hetero ZFYV9_HUMAN homo 
YEATPICSLDGKRVFHMNQ
 REGION /note="Linker" REGION /note="Linker"
226Y b 17.8 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN homo 
YVPSFAEGLDHIKMNQRT
 REGION /note="Linker" REGION /note="Linker"
227C e 27.3 1mk2_A hetero SKI_HUMAN homo precipitant 
EKPNRSVCQWALDFGITY
 REGION /note="Linker" REGION /note="Linker"
228E e 74.4 1mk2_A hetero SKI_HUMAN homo precipitant 
EHTDKAGILPRSV
 REGION /note="Linker" REGION /note="Linker"
229P b 7.8 1mk2_A hetero SMAD3_HUMAN homo precipitant 
PERSADGIKLTV
 REGION /note="Linker" REGION /note="Linker"
230ASe 75.9 1mk2_A homo precipitant 
KASQDPEGILRTV
 REGION /note="Linker" REGION /note="Linker"
231FSe 53.6 1mk2_A compound TAR precipitant 
HSFPNYADEGIKLRTV
 REGION /note="Linker" REGION /note="Linker"
232W b 2.8 1mk2_A hetero SKI_HUMAN precipitant 
W
 DOMAIN /note="MH2" DOMAIN /note="MH2"
233CEb 0.0 1mk2_A 
CAGL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
234SEb 13.3 1mk2_A homo 
STKVQN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
235IEb 0.0 1mk2_A 
IVL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
236SEb 7.0 1mk2_A precipitant 
AVIFST
 DOMAIN /note="MH2" DOMAIN /note="MH2"
237YEb 0.0 1mk2_A 
Y
 DOMAIN /note="MH2" DOMAIN /note="MH2"
238YEb 18.7 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
YWF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
239EEb 1.0 1mk2_A 
E
 DOMAIN /note="MH2" DOMAIN /note="MH2" E->K:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795]
240LTe 28.7 1mk2_A 
LEHKM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
241NTe 75.2 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
NRDTGK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
242QEe 36.7 1mk2_A 
TVNLQSC
 DOMAIN /note="MH2" DOMAIN /note="MH2"
243REe 30.4 1mk2_A hetero SMAD4_HUMAN homo precipitant 
RQMP
 DOMAIN /note="MH2" DOMAIN /note="MH2"
244VEb 2.7 1mk2_A precipitant 
VIL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
245GEe 36.9 1mk2_A metal CL homo precipitant 
G
 DOMAIN /note="MH2" DOMAIN /note="MH2"
246EEe 84.4 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN metal CL homo precipitant 
ERK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
247TEe 34.4 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo 
TLAKVQ
 DOMAIN /note="MH2" DOMAIN /note="MH2"
248FEb 10.5 1mk2_A compound TAR homo precipitant 
FYAVDEGKLST
 DOMAIN /note="MH2" DOMAIN /note="MH2"
249HEe 50.3 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN compound TAR homo precipitant 
KHAEDCQTL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
250AEb 0.0 1mk2_A homo 
VACLS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
251S e 31.2 1mk2_A homo 
SYKEQVN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
252QSe 39.3 1mk2_A homo 
SEDVGHNRQC
 DOMAIN /note="MH2" DOMAIN /note="MH2"
253PSe 58.1 1mk2_A 
PGQTHLRN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
254SEe 28.1 1mk2_A homo precipitant 
STAHKNV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
255MEb 0.0 1mk2_A homo 
VILCFM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
256TEb 6.5 1mk2_A homo 
TLSIHAEGV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
257VEb 0.0 1mk2_A 
VIAEGLS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
258DEb 3.1 1mk2_A 
DAEFGIKLNPQRSTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
259G b 17.9 1mk2_A hetero SMAD4_HUMAN SMAD2_HUMAN homo 
GIADEFKLNPQRSTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
260F e 38.8 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
FYAG
 DOMAIN /note="MH2" DOMAIN /note="MH2"
261TSe 64.3 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
TYIMV
 DOMAIN /note="MH2" DOMAIN /note="MH2" T->I:(9.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795]
262DSe 45.1 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
DGCN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
263P e 69.8 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
PLSA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
264S e 37.5 1mk2_A hetero SMAD3_HUMAN SMAD4_HUMAN SMAD2_HUMAN homo precipitant 
SEPC
 DOMAIN /note="MH2" DOMAIN /note="MH2"
265NBe 35.8 1mk2_A hetero SMAD4_HUMAN homo precipitant 
NQDTG
 DOMAIN /note="MH2" DOMAIN /note="MH2"
266STe 48.4 1mk2_A homo precipitant 
GESNRADKLTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
267ETe 22.1 1mk2_A homo 
SNCDGEKRALTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
268REe 25.7 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
RGK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
269FEb 4.8 1mk2_A homo precipitant 
FIMLYC
 DOMAIN /note="MH2" DOMAIN /note="MH2"
270CEb 1.3 1mk2_A homo precipitant 
CS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
271L b 0.6 1mk2_A 
L
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
272GTe 22.6 1mk2_A hetero SMAD4_HUMAN compound TAR homo 
GT
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
273LTe 53.9 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo precipitant 
QLSAW
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
274L b 19.1 1mk2_A compound TAR metal CL homo precipitant 
LQEYF
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
275S e 78.1 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo precipitant 
SNPT
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
276N b 13.3 1mk2_A hetero SMAD4_HUMAN precipitant 
NSL
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
277VTe 97.3 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
VPEDAGIKLRST
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
278NTe 69.1 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
NHQSI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
279R e 24.1 1mk2_A hetero SMAD4_HUMAN compound TAR homo precipitant 
RK
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" R->K:(8.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795]
280N e 41.8 1mk2_A 
NSTE
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
281AHe 62.5 1mk2_A 
ESPAQG
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
282AHe 50.0 1mk2_A 
TAKSQVL
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
283VHb 1.3 1mk2_A 
IVSAT
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
284EHe 39.2 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN homo precipitant 
ERSAFQ
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
285LHe 53.9 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo 
NKRQELM
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
286THb 10.4 1mk2_A homo 
TVAI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
287RHb 10.3 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo 
R
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" R->W:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795]
288RTe 64.0 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
RSNGIKLM
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
289HTe 50.8 1mk2_A hetero SKIL_HUMAN SKI_HUMAN SMAD3_HUMAN SMAD4_HUMAN SMAD2_HUMAN homo 
HKTAL
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
290ITb 0.6 1mk2_A 
IV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
291GTe 27.4 1mk2_A homo 
GV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
292RTe 58.5 1mk2_A hetero SMAD4_HUMAN homo 
KRAFDCNY
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
293G b 0.0 1mk2_A 
G
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
294VEb 0.0 1mk2_A 
VI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
295REe 32.8 1mk2_A homo precipitant 
QRHLEK
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
296LEb 0.0 1mk2_A 
LF
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
297YEe 30.0 1mk2_A hetero ZFYV9_HUMAN homo precipitant 
YASTDE
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
298YEb 10.4 1mk2_A hetero SKI_HUMAN CBP_HUMAN precipitant 
YKHLRCN
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
299IEe 53.8 1mk2_A hetero ZFYV9_HUMAN homo 
EKVALI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
300GTe 88.1 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
GDNPAVET
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
301GTb 1.2 1mk2_A hetero SKI_HUMAN CBP_HUMAN 
GD
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
302EEb 7.5 1mk2_A 
EGSNDQ
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
303VEb 1.3 1mk2_A hetero SKI_HUMAN 
VIL
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
304FEe 24.4 1mk2_A hetero ZFYV9_HUMAN homo 
WYFMAEGLSV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
305AEb 0.0 1mk2_A 
AVLIEGS
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
306EEe 22.1 1mk2_A homo precipitant 
EYTQSR
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
307CEb 0.0 1mk2_A 
NCVI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
308L e 23.0 1mk2_A homo 
LRTNEV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
309SSb 1.6 1mk2_A 
SGTCM
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
310DSe 79.6 1mk2_A hetero SKI_HUMAN SMAD4_HUMAN SKIL_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
DNEKS
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
311SSb 18.8 1mk2_A hetero SKI_HUMAN SKIL_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
SHYQCIMT
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
312A b 12.5 1mk2_A homo precipitant 
PASIK
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
313IEb 0.0 1mk2_A 
IV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
314FEb 5.7 1mk2_A homo precipitant 
F
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
315VEb 0.0 1mk2_A 
VI
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
316QEe 20.4 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo precipitant 
QNRTK
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
317S b 0.0 1mk2_A 
SC
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
318PHe 20.9 1mk2_A precipitant 
PGRIAKYS
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
319NHb 0.0 1mk2_A homo 
NYTFG
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
320CHb 0.0 1mk2_A hetero SKIL_HUMAN SKI_HUMAN 
LCAT
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
321NHb 5.5 1mk2_A precipitant 
NDR
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
322QHe 40.8 1mk2_A homo precipitant 
QYAMNLRTF
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
323RGb 16.2 1mk2_A hetero SKI_HUMAN homo 
THSKPREMIQADFGLNV
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
324YGe 55.2 1mk2_A hetero ZFYV9_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SKIL_HUMAN MAN1_HUMAN 
HNGLPDYAM
 REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2"
325GGe 78.6 1mk2_A homo 
GNS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
326W e 38.2 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SKIL_HUMAN homo precipitant 
FGKLSMRWADEINPQTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
327H e 74.9 1mk2_A hetero MAN1_HUMAN THIO_ECOLI FOXH1_HUMAN homo precipitant 
HRPKEQA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
328PTe 61.2 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo precipitant 
PLAKYTS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
329ATe 55.4 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN MAN1_HUMAN homo precipitant 
LTASKDNGV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
330T e 25.3 1mk2_A hetero MAN1_HUMAN SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN ZFYV9_HUMAN SKI_HUMAN precipitant 
TKVYSLAI
 DOMAIN /note="MH2" DOMAIN /note="MH2"
331V b 10.7 1mk2_A hetero MAN1_HUMAN SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN precipitant 
VK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
332CEb 17.3 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN metal CL 
CHRFASV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
333KEe 61.8 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SMAD3_HUMAN SMAD2_HUMAN metal CL homo precipitant 
KRH
 MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409." DOMAIN /note="MH2" MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409." DOMAIN /note="MH2"
334IEb 2.3 1mk2_A hetero SKIL_HUMAN ZFYV9_HUMAN SKI_HUMAN MAN1_HUMAN 
IVLT
 DOMAIN /note="MH2" DOMAIN /note="MH2"
335P e 38.0 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN 
PYQFAM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
336PTe 41.9 1mk2_A hetero MAN1_HUMAN SKI_HUMAN SKIL_HUMAN homo 
PNSG
 DOMAIN /note="MH2" DOMAIN /note="MH2"
337GTe 76.2 1mk2_A hetero ZFYV9_HUMAN SKIL_HUMAN SKI_HUMAN precipitant 
GKCETSHR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
338C e 37.3 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SKIL_HUMAN 
CGASYF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
339NEe 51.5 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN THIO_ECOLI FOXH1_HUMAN compound TAR homo precipitant 
SDTNQY
 DOMAIN /note="MH2" DOMAIN /note="MH2"
340LEb 14.6 1mk2_A hetero MAN1_HUMAN ZFYV9_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SKIL_HUMAN compound TAR 
ILMF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
341KEe 27.4 1mk2_A 
KTC
 MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409." DOMAIN /note="MH2" MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409." DOMAIN /note="MH2"
342IEb 0.0 1mk2_A 
VITA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
343FEb 0.0 1mk2_A hetero SKI_HUMAN 
F
 DOMAIN /note="MH2" DOMAIN /note="MH2"
344N b 12.1 1mk2_A 
DNGE
 DOMAIN /note="MH2" DOMAIN /note="MH2"
345NHb 10.3 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
NFMYKISL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
346QHe 63.8 1mk2_A hetero SKI_HUMAN CBP_HUMAN ZFYV9_HUMAN homo 
EQRKN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
347EHb 17.6 1mk2_A precipitant 
QELKAIR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
348FHb 0.0 1mk2_A hetero SKI_HUMAN 
FSMYAIR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
349AHe 26.8 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN homo 
ASEMYFCGR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
350AHe 52.7 1mk2_A hetero CBP_HUMAN 
QLKTSAPGE
 DOMAIN /note="MH2" DOMAIN /note="MH2"
351LHb 10.7 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN 
LMEQA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
352LHb 2.8 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
LKQYIADEFGNPRSTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
353AHe 50.9 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
ARELTHSDFGIKNPQV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
354QHe 54.6 1mk2_A 
QLTRAD
 DOMAIN /note="MH2" DOMAIN /note="MH2"
355SHb 6.2 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN 
SAGRCP
 DOMAIN /note="MH2" DOMAIN /note="MH2"
356VHe 27.3 1mk2_A hetero ZFYV9_HUMAN SKI_HUMAN CBP_HUMAN 
VAEKLRPCS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
357NTe 78.2 1mk2_A hetero CBP_HUMAN homo 
NLGESAHPR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
358QTe 63.3 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo precipitant 
DHQPKSTARN
 DOMAIN /note="MH2" DOMAIN /note="MH2"
359GHe 36.9 1mk2_A homo precipitant 
GLPNTSAHYEV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
360FHe 60.3 1mk2_A hetero SMAD4_HUMAN ZFYV9_HUMAN homo precipitant 
FAMTDYHIL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
361EHe 81.4 1mk2_A homo precipitant 
EDNQSL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
362AHb 11.6 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo 
GAKDYFVT
 DOMAIN /note="MH2" DOMAIN /note="MH2"
363VHb 0.0 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo 
VEPIMLAS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
364YHe 56.5 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
YDVQNFH
 DOMAIN /note="MH2" DOMAIN /note="MH2"
365QGe 50.5 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo 
EDQACRG
 DOMAIN /note="MH2" DOMAIN /note="MH2"
366LGb 5.6 1mk2_A homo 
LPDM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
367TGe 20.8 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo precipitant 
TSRENAWQY
 DOMAIN /note="MH2" DOMAIN /note="MH2"
368RGe 49.8 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo precipitant 
RKTDAEGILPSV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
369MGb 1.0 1mk2_A 
MYFGHLPADEIKRSTV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
370CGb 0.0 1mk2_A homo 
CSFHTADEGIKLPRV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
371TEe 23.4 1mk2_A compound TAR homo 
TSFNCI
 DOMAIN /note="MH2" DOMAIN /note="MH2"
372IEb 0.0 1mk2_A 
IVL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
373REe 33.2 1mk2_A hetero SMAD2_HUMAN compound TAR homo precipitant 
RAQ
 DOMAIN /note="MH2" DOMAIN /note="MH2"
374MEb 1.0 1mk2_A 
IMV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
375SEb 0.8 1mk2_A 
S
 DOMAIN /note="MH2" DOMAIN /note="MH2"
376FEb 1.0 1mk2_A 
F
 DOMAIN /note="MH2" DOMAIN /note="MH2"
377VSb 19.3 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo 
VCA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
378K e 43.9 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
K
 MOD_RES /note="N6-acetyllysine" MUTAGEN /note="K->Q: Increased transcriptional activity. No further increase in transcriptional activity with EP300." MUTAGEN /note="K->R: Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409." DOMAIN /note="MH2" MOD_RES /note="N6-acetyllysine" MUTAGEN /note="K->Q: Increased transcriptional activity. No further increase in transcriptional activity with EP300." MUTAGEN /note="K->R: Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409." DOMAIN /note="MH2"
379G b 4.8 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo 
GA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
380W b 1.2 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo precipitant 
WF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
381GSb 13.1 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN homo 
G
 DOMAIN /note="MH2" DOMAIN /note="MH2"
382ATe 67.0 1mk2_A hetero MAN1_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SKIL_HUMAN homo 
EAPDQ
 DOMAIN /note="MH2" DOMAIN /note="MH2"
383ETe 77.9 1mk2_A hetero MAN1_HUMAN THIO_ECOLI FOXH1_HUMAN ZFYV9_HUMAN SKI_HUMAN SKIL_HUMAN homo precipitant 
ECDTAHVK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
384YSe 27.4 1mk2_A hetero SKIL_HUMAN THIO_ECOLI FOXH1_HUMAN SKI_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
Y
 DOMAIN /note="MH2" DOMAIN /note="MH2"
385RSe 79.8 1mk2_A hetero SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
SHRQPET
 DOMAIN /note="MH2" DOMAIN /note="MH2"
386RSe 30.8 1mk2_A hetero ZFYV9_HUMAN SMAD3_HUMAN SMAD2_HUMAN metal CL homo precipitant 
R
 DOMAIN /note="MH2" DOMAIN /note="MH2"
387Q e 60.7 1mk2_A hetero THIO_ECOLI FOXH1_HUMAN metal CL homo precipitant 
QLKPS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
388TSe 48.1 1mk2_A homo precipitant 
DTFSK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
389VGb 4.0 1mk2_A homo precipitant 
VI
 DOMAIN /note="MH2" DOMAIN /note="MH2"
390TGe 39.6 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
TKVHLS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
391SGe 29.7 1mk2_A metal CL precipitant 
SENDR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
392TSb 0.0 1mk2_A 
TCLS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
393PSb 3.9 1mk2_A 
P
 DOMAIN /note="MH2" DOMAIN /note="MH2" P->L:(0.0 %):US A colorectal cancer sample
394CSb 0.0 1mk2_A 
CV
 DOMAIN /note="MH2" DOMAIN /note="MH2"
395WEb 5.2 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
W
 DOMAIN /note="MH2" DOMAIN /note="MH2"
396IEb 0.0 1mk2_A 
ILF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
397EEb 9.5 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
EQ
 DOMAIN /note="MH2" DOMAIN /note="MH2"
398LEb 0.0 1mk2_A 
ILVA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
399HEe 22.5 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo precipitant 
HILKTR
 DOMAIN /note="MH2" DOMAIN /note="MH2"
400LEb 1.7 1mk2_A homo 
LIF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
401NHe 21.8 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
NHS
 DOMAIN /note="MH2" DOMAIN /note="MH2"
402GHb 0.0 1mk2_A hetero SKI_HUMAN 
GNREIVA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
403PHb 2.3 1mk2_A 
PA
 DOMAIN /note="MH2" DOMAIN /note="MH2"
404LHe 25.3 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
LAYM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
405QHe 40.3 1mk2_A hetero SKI_HUMAN SMAD4_HUMAN SMAD3_HUMAN homo 
QDAH
 DOMAIN /note="MH2" DOMAIN /note="MH2"
406WHb 10.0 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
WEFIYL
 DOMAIN /note="MH2" DOMAIN /note="MH2"
407LHb 0.0 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
LMYVI
 DOMAIN /note="MH2" DOMAIN /note="MH2"
408DHe 60.5 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
D
 DOMAIN /note="MH2" DOMAIN /note="MH2"
409KHe 44.3 1mk2_A hetero SKI_HUMAN CBP_HUMAN homo 
KSQTER
 MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378." DOMAIN /note="MH2" MUTAGEN /note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378." DOMAIN /note="MH2"
410VHb 4.7 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
VILK
 DOMAIN /note="MH2" DOMAIN /note="MH2"
411LHb 17.4 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
LFM
 DOMAIN /note="MH2" DOMAIN /note="MH2"
412THe 51.9 1mk2_A hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo 
TSKH
 DOMAIN /note="MH2" DOMAIN /note="MH2"
413QHe 43.9 1mk2_A hetero SKI_HUMAN ZFYV9_HUMAN CBP_HUMAN 
QTC
 DOMAIN /note="MH2" DOMAIN /note="MH2"
414MHe 39.1 1mk2_A hetero ZFYV9_HUMAN CBP_HUMAN homo 
MF
 DOMAIN /note="MH2" DOMAIN /note="MH2"
415G e 66.7 1mk2_A homo 
G
 DOMAIN /note="MH2" DOMAIN /note="MH2"
416S e107.8 1mk2_A hetero ZFYV9_HUMAN SMAD4_HUMAN homo precipitant 
SAP
 MOD_RES /note="Phosphoserine" ECO:0007744|PubMed:23186163" DOMAIN /note="MH2" MOD_RES /note="Phosphoserine" ECO:0007744|PubMed:23186163" DOMAIN /note="MH2"
417P e 62.0 6m64_A hetero SMAD4_HUMAN homo precipitant 
PT
 DOMAIN /note="MH2" DOMAIN /note="MH2"
418SSe100.0 6m64_A homo precipitant 
PHSL
 MOD_RES /note="Phosphoserine; by CK1" ECO:0000269|PubMed:18794808" MUTAGEN /note="S->A: Increased constitutive activity." MUTAGEN /note="S->D: Decreased activity." DOMAIN /note="MH2" MOD_RES /note="Phosphoserine; by CK1" ECO:0000269|PubMed:18794808" MUTAGEN /note="S->A: Increased constitutive activity." MUTAGEN /note="S->D: Decreased activity." DISORDER predicted by DISOPRED DOMAIN /note="MH2"
419ISe 79.3 6m64_A hetero SMAD4_HUMAN homo 
NRIV
 DOMAIN /note="MH2" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
420R e 80.6 6m64_A hetero SMAD4_HUMAN homo 
PIRA
 DOMAIN /note="MH2" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
421C e 60.7 6m64_A hetero SMAD4_HUMAN homo 
IC
 DOMAIN /note="MH2" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
422S e 47.7 6m64_A hetero SMAD4_HUMAN homo 
S
 MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DOMAIN /note="MH2" MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
423SSe 89.9 6m64_A hetero SMAD4_HUMAN homo 
S
 MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DOMAIN /note="MH2" MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
424V e 84.1 6m64_A hetero SMAD4_HUMAN homo 
VIM
 MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DOMAIN /note="MH2" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DISORDER predicted by DISOPRED DOMAIN /note="MH2"
425S e118.8 1khu_A homo 
S
 MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DOMAIN /note="MH2" MOD_RES /note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439" MUTAGEN /note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" MUTAGEN /note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174" DISORDER predicted by DISOPRED DOMAIN /note="MH2"