Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
16000 468 109 P08887(IL6RA_HUMAN) RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;
QUERYSEQ 
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLV
RKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
RDPRSPYDISNTDYFFPR
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ] 
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
1M---- 
M
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
2L---- 
LM
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
3A---- 
SAT
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
4V---- 
VS
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
5G---- 
GS
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
6C---- 
C
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
7A---- 
SAT
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
8L---- 
LG
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
9L---- 
LS
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
10A---- 
VTLSA
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
11A---- 
VAR
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
12L---- 
LVF
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
13L---- 
L
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
14A---- 
AVT
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
15A---- 
AS
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
16P---- 
PV
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
17G---- 
ALIG
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
18A---- 
VMTAL
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
19A---- 
A
 SIGNAL SIGNAL
20L e 45.5 1n26_A 
LIM
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
21A b 4.5 1n26_A 
WVA
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
22PSb 6.2 1n26_A 
ESLP
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
23RSe 88.1 1n26_A 
LSGR
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
24R e 73.1 1n26_A 
ESKPGR
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
25C b 10.0 1n26_A 
CK
 DISULFID ECO:0000269|PubMed:10066782" TOPO_DOM /note="Extracellular" DISULFID ECO:0000269|PubMed:10066782" TOPO_DOM /note="Extracellular"
26P e 42.6 1n26_A 
PDNRS
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
27A e 31.2 1n26_A 
VQAK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
28Q e 34.2 1n26_A 
YALQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
29E e 84.4 1n26_A 
VEWI
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
30V e 32.0 1n26_A 
VG
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
31A e 65.2 1n26_A 
EAP
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
32RTe 91.7 1n26_A 
LPNVQR
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
33GTe 90.5 1n26_A 
DG
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
34VEe 24.7 1n26_A 
WVT
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
35LEe 41.6 1n26_A 
YQLVSH
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
36TEe 32.5 1n26_A 
TPY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
37SEb 10.2 1n26_A 
DSGLN
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
38L e 37.1 1n26_A 
LAQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
39PTe 37.2 1n26_A hetero 
PILA
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
40GTe 47.6 1n26_A 
G
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
41D e 45.7 1n26_A metal TB 
EASRD
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
42S e 61.7 1n26_A hetero 
TSMPDRK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
43VEb 8.0 1n26_A 
VL
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
44TEe 39.0 1n26_A 
VTMNQK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
45LEb 0.0 1n26_A 
LAIM
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
46TEe 25.3 1n26_A 
TCIKR
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
47C b 0.0 1n26_A 
C
 DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
48PTe 65.1 1n26_A 
PDNSGH
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
49GTe 66.7 1n26_A 
GTSADEKLPV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
50VSb 1.3 1n26_A 
VAKSMPGLDEIRTCFHNQY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
51E e 64.8 1n26_A 
ETDSNLAGIKPRVCFHMQY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
52PTe 75.2 1n26_A 
PAEWGLSVDFHIKMNQRTY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
53ETe 56.3 1n26_A compound NAG 
EDGALFIKNPQRSTVY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
54D e 32.7 1n26_A compound NAG 
DEGALFIKNPQRSTVY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
55N e 72.1 1n26_A compound NAG 
DNGALEKSTVFIPQRYCHMW
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: Strongly induces cleavage and sIL6R levels. No effect on IL6R signaling; when associated with A-93, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-93, A-221, A-245 and A-350." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: Strongly induces cleavage and sIL6R levels. No effect on IL6R signaling; when associated with A-93, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-93, A-221, A-245 and A-350." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
56ASe 22.3 1n26_A 
AGTVILSDEFKNPQRCHMWY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
57TEe 51.9 1n26_A 
TPALGSVDEIKRFNQYCHMW
 MUTAGEN /note="T->A: Strongly induces cleavage and sIL6R levels." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" MUTAGEN /note="T->A: Strongly induces cleavage and sIL6R levels." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
58VEb 0.0 1n26_A 
IVLADEGKNPQRST
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
59HEe 51.3 1n26_A homo 
THSYIADEGKLNPQRV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
60WEb 0.8 1n26_A 
WADEGKLPSTV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
61VEb 3.3 1n26_A 
TVFLAEGSDIKNPQRCHMWY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
62LEb 2.2 1n26_A hetero 
LYFRSADEGKTVINPQCHMW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
63REe 37.2 1n26_A compound NAG otherpoly 
RDLNQAGEKPSTVFIYCHMW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
64K e 25.5 1n26_A otherpoly 
KGDENQALPSTVFIRYCHMW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
65PSe 77.5 1n26_A otherpoly 
PRGQNSALDEKTVFIYCHMW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
66ASe 58.0 1n26_A 
RADKSVGLEFINPQTCHMWY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
67ASe 92.9 1n26_A 
TSLQNEAG
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
68GSe101.2 1n26_A 
GSPRLAV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
69S e 32.8 1n26_A hetero 
SDCLTQAEGIKPRV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
70H e 56.5 1n26_A hetero 
QHEDLGPRAIKSTV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
71P e 55.0 1n26_A hetero 
SLPYIQDNKAEGRTV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
72SEe 21.9 1n26_A 
SDGRNAEIKLPTV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
73REe 68.4 1n26_A hetero homo 
ERDPAFGIKLNQSTVY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
74WEe 41.8 1n26_A homo 
VWLRSDPIAEFGKNQTY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
75AEe 62.5 1n26_A hetero homo 
LASNTVH
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
76GEb 15.5 1n26_A 
GKNTL
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
77MEe 67.6 1n26_A homo 
SLTVNM
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
78GSb 14.3 1n26_A 
GISK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
79RSe 24.1 1n26_A 
KHSLMTNRY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
80REe 55.3 1n26_A hetero homo 
TRYLQVE
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
81LEe 20.8 1n26_A homo 
LYAKV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
82LEe 51.7 1n26_A hetero homo 
VTLIFQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
83LEb 8.4 1n26_A hetero homo 
LIVD
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
84R e 87.7 1n26_A hetero homo 
RQAKNLH
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
85SSe 41.4 1n26_A 
VSQAGRCND
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
86V b 0.0 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN 
VKRILSA
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
87Q e 35.7 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN 
EDQCKNRL
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
88LGe 45.5 1n26_A hetero I12R1_HUMAN 
FLSAQMTV
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
89HGe 60.2 1n26_A hetero otherpoly 
GESHTLQPNRA
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
90DGb 19.8 1n26_A hetero metal NA homo 
DHSQN
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
91S b 13.3 1n26_A hetero otherpoly 
ASGEPTI
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
92GEb 3.6 1n26_A 
GDH
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
93NEe 35.2 1n26_A hetero CLCF1_HUMAN compound NAG otherpoly 
QENTYLHSDGW
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-221, A-245 and A-350." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-221, A-245 and A-350." DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
94YEb 0.4 1n26_A hetero 
YLW
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
95SEb 9.4 1n26_A hetero CLCF1_HUMAN 
TSVALNI
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
96CEb 0.7 1n26_A 
CES
 DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
97YEe 24.8 1n26_A 
HRWQFYTS
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
98RSe 39.5 1n26_A 
KTRSHLVEAQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
99ASe 90.2 1n26_A 
GSDLTNA
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
100GSe 63.1 1n26_A 
GEWDS
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
101RSe 79.4 1n26_A hetero 
EHRVFSALK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
102P e101.6 1n26_A hetero CLCF1_HUMAN 
PVLDITASF
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
103ASb 8.9 1n26_A hetero 
LGVTRAK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
104G e 35.7 1n26_A otherpoly 
SGIATHCY
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
105TEe 30.5 1n26_A hetero CLCF1_HUMAN 
TQHGRIMS
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
106VEb 13.3 1n26_A hetero metal K NA 
VSITM
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
107HEe 41.9 1n26_A hetero I12R1_HUMAN CLCF1_HUMAN IL11_HUMAN IL27A_HUMAN IL27B_MOUSE IL27A_MOUSE DAPK1_HUMAN compound NAG metal K otherpoly 
LTERHNCGPYDFQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
108LEb 2.2 1n26_A 
LIM
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
109LEe 24.2 1n26_A hetero CLCF1_HUMAN metal K NA 
LHKIYFRSAQT
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
110VEb 2.7 1n26_A hetero metal CL 
VLSIGKT
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
111D b 0.6 1n26_A 
GDQEHK
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
112V e 40.0 1n26_A hetero IL23A_HUMAN precipitant 
VILSFYAKQ
 DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular" DOMAIN /note="Ig-like C2-type" TOPO_DOM /note="Extracellular"
113P e 50.4 1n26_A hetero IL23A_HUMAN IL23R_HUMAN 
PLDAFVK
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
114P b 14.0 1n26_A hetero IL23A_HUMAN IL23R_HUMAN otherpoly 
PKQGR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
115E b 19.6 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN otherpoly precipitant 
EDKGANR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
116E e 39.7 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE IL23R_HUMAN otherpoly precipitant 
KQERDPI
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
117P b 0.0 1n26_A hetero IL23R_HUMAN CALM1_HUMAN 
PKTS
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
118Q e 61.7 1n26_A hetero IL23R_HUMAN compound NAG metal K NA otherpoly 
EKRQNVFGT
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
119L b 11.8 1n26_A otherpoly 
LIVN
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
120SEe 47.7 1n26_A compound NAG otherpoly precipitant 
SKTIFQMRHV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
121CEb 6.7 1n26_A hetero precipitant 
CKVTR
 MUTAGEN /note="C->S: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->S: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
122FEe 23.0 1n26_A precipitant 
EICFRVWMADGKLNPQSTY
 MUTAGEN /note="F->A: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="F->A: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
123RBb 1.6 1n26_A hetero precipitant 
ARSQVL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
124KSe 27.8 1n26_A 
KSNAER
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
125SSb 0.8 1n26_A hetero metal NA precipitant 
NPTEGDSVCRAL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
126PTb 0.0 1n26_A hetero IL23A_HUMAN IL6_HUMAN I12A_HUMAN IL12A_HUMAN CLCF1_HUMAN compound NAG otherpoly 
YEGDPSN
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
127LTe 52.2 1n26_A hetero IL6_HUMAN PRL_HUMAN IL11_HUMAN IL27A_HUMAN compound NAG 
SKAPLYMRNQDEGTV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
128SSe 30.5 1n26_A hetero PRL_HUMAN IL6_HUMAN CSH_SHEEP compound NAG otherpoly 
GEKSAIV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
129N e 35.8 1n26_A hetero compound NAG metal NA otherpoly precipitant 
NTRGHSDAK
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
130VEb 0.0 1n26_A metal NA 
FVMILA
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
131VEb 16.7 1n26_A hetero metal NA otherpoly precipitant 
TSAYLDRFGIV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
132CEb 0.0 1n26_A 
CL
 MUTAGEN /note="C->A: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->A: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
133EEe 20.1 1n26_A hetero otherpoly precipitant 
WSTEQRA
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
134WEb 4.8 1n26_A metal NA 
WL
 MUTAGEN /note="W->L: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="W->L: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
135G e 40.5 1n26_A otherpoly 
GSDTKHIRELNAPV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
136P b 10.1 1n26_A hetero IL23A_HUMAN 
PSRTLGFADEIKV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
137RSe 73.9 1n26_A hetero IL23A_HUMAN precipitant 
GSRTAPDEIKLV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
138SSe 60.2 1n26_A 
SRDAYQPEKTIVGNL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
139T e 55.8 1n26_A 
DLVIPTENHSA
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
140P e 20.2 1n26_A precipitant 
TGPSQAR
 MUTAGEN /note="P->G: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="P->G: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
141S e 27.3 1n26_A compound NAG otherpoly precipitant 
GNASYEHD
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
142LTe 93.3 1n26_A hetero 
LSTIVPFH
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
143TTe 27.9 1n26_A compound NAG otherpoly precipitant 
TPSFEYKG
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
144T b 7.8 1n26_A hetero compound NAG otherpoly 
TCLNIS
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
145KEe 57.1 1n26_A compound NAG otherpoly precipitant 
NRGKDHAEPVIT
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
146AEb 4.5 1n26_A hetero compound NAG otherpoly 
YATVLGSK
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
147VEe 25.3 1n26_A hetero LIF_HUMAN compound NAG otherpoly 
TVAKLSNFE
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
148LEb 0.0 1n26_A hetero IL11_HUMAN IL6_HUMAN Q98823_HHV8 LIF_HUMAN CNTF_HUMAN 
LFTVISYWM
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
149LEb 1.1 1n26_A hetero LIF_HUMAN IL11_HUMAN precipitant 
SLQTHFIAKVY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
150VEb 0.0 1n26_A hetero IL11_HUMAN Q98823_HHV8 LIF_HUMAN CLCF1_HUMAN CNTF_HUMAN precipitant 
YLVSAGQTDEIKPR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
151REe 28.5 1n26_A hetero IL11_HUMAN LIF_HUMAN IL6_HUMAN IL6RB_HUMAN IL6RB_MOUSE CNTF_HUMAN compound NAG otherpoly precipitant 
KRSTAHYNDEGILPV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
152KEb 16.0 1n26_A hetero IL11_HUMAN LIF_HUMAN 
KSEGYRADILPTV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
153FEe 42.6 1n26_A hetero IL11_HUMAN IL6RB_HUMAN IL6RB_MOUSE IL6_HUMAN CNTF_HUMAN compound NAG otherpoly 
KPFRSIVEHMAGLDNQTY
 MUTAGEN /note="F->L: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="F->L: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
154QSe 44.9 1n26_A hetero IL11_HUMAN IL6RB_HUMAN IL6_HUMAN 
RVLTNMDKASQYEFGIP
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
155NSe100.0 1n26_A hetero IL6_HUMAN IL11_HUMAN IL6RB_MOUSE IL6RB_HUMAN 
NGRTVLDESAFIKPQY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
156SSe 51.6 1n26_A hetero IL6RB_HUMAN CLCF1_HUMAN IL11_HUMAN IL27A_HUMAN IL6RB_MOUSE 
SLVWCPTGKMADEFINQRY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
157PSe 90.7 1n26_A hetero PRL_HUMAN IL6RB_HUMAN CLCF1_HUMAN IL6RB_MOUSE CSH_SHEEP compound NAG 
EDAGKSTNYPVILQR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
158A e 43.8 1n26_A hetero PRL_HUMAN IL6RB_HUMAN IL6RB_MOUSE metal CL precipitant 
AGSKNTCQRVEDILP
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
159EEe 57.3 1n26_A hetero IL6RB_HUMAN otherpoly 
EDKRQTVGLSMAFINPY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
160DEe 32.7 1n26_A hetero IL6_HUMAN IL11_HUMAN 
DTESVKGILWAPR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
161FEe 27.3 1n26_A 
FYHQLWASKNRVDITEGP
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
162QEe 59.7 1n26_A hetero IL11_HUMAN IL6_HUMAN precipitant 
QRIPTSAVEGKNMDFL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
163EEe 26.6 1n26_A hetero IL11_HUMAN otherpoly 
EKHSDNVYWRALFGIPQT
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
164PEe 64.3 1n26_A otherpoly 
PEQYSTKNRAGLVDFHIM
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
165CEb 11.3 1n26_A 
CSKNRVFADEGILPQTWY
 MUTAGEN /note="C->L: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->L: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
166QEe 52.6 1n26_A otherpoly 
KEPQFRCDNAGILSTV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
167YEe 26.5 1n26_A hetero 
YDREHILSTAGKPV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
168SEe 28.9 1n26_A metal NA 
YSTKPQDCEIRL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
169QTe 78.1 1n26_A hetero precipitant 
VQKHLRCFDNI
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
170ETe 98.0 1n26_A hetero compound NAG precipitant 
ETPRDKAGQSY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
171STe 46.1 1n26_A hetero 
CALSGQVYPTDKH
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
172QTe 32.1 1n26_A hetero metal NA precipitant 
QGLSTKDNEH
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
173KEe 34.0 1n26_A hetero 
PESKRDCGL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
174FEb 1.9 1n26_A metal NA 
NLFGTDHYAEIKPQRSV
 MUTAGEN /note="F->L: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="F->L: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
175SEe 21.9 1n26_A hetero I12A_HUMAN compound MNB metal NA precipitant 
SGRKFTADEILPV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
176CEb 0.0 1n26_A precipitant 
CILAVEGSTDFHKMNPQRY
 MUTAGEN /note="C->A: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->A: Complete loss of ligand-binding." DISULFID ECO:0000269|PubMed:10066782" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
177QEe 44.9 1n26_A hetero metal NA otherpoly precipitant 
HYDQTNMVAEFGKLSCIPR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
178LEb 1.1 1n26_A 
IVFLMRCAEGKSTDHNPQY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
179A e 59.8 1n26_A hetero I12A_HUMAN compound NAG MNB precipitant 
ATSPDGHENRCFIKLQV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
180V b 4.7 1n26_A hetero IL23A_HUMAN PRL_HUMAN I12A_HUMAN IL12A_HUMAN IL11_HUMAN compound MNB metal NA precipitant 
CKVYIGRALSDEFHMNPQT
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
181P e 55.8 1n26_A hetero IL6_HUMAN IL11_HUMAN CLCF1_HUMAN IL27A_HUMAN I12A_HUMAN IL12A_HUMAN CNTF_HUMAN 
PMQAKDLNVEFGIRSTY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
182ETe 31.7 1n26_A hetero IL23A_HUMAN IL6_HUMAN IL11_HUMAN IL27A_HUMAN I12A_HUMAN IL12A_HUMAN CNTF_HUMAN compound NAG otherpoly 
EAHLTYDKSNFGIPQRV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
183GTe 63.1 1n26_A hetero IL23A_HUMAN IL6_HUMAN IL11_HUMAN CLCF1_HUMAN PRL_HUMAN IL27A_HUMAN IL12A_HUMAN CNTF_HUMAN compound CYS metal NA 
AGTFLSKDEINPQRV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
184D b 5.6 1n26_A hetero IL23A_HUMAN PRL_HUMAN IL11_HUMAN CLCF1_HUMAN IL27A_HUMAN I12A_HUMAN CSH_SHEEP IL12A_HUMAN CNTF_HUMAN compound CYS 
ESDALWFPNYHGIKQRTV
 MUTAGEN /note="D->T: 30% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="D->T: 30% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
185S e 64.1 1n26_A hetero IL11_HUMAN PRL_HUMAN IL6_HUMAN CLCF1_HUMAN Q98823_HHV8 LIF_HUMAN IL27A_HUMAN CSH_SHEEP IL23A_HUMAN CNTF_HUMAN compound CYS homo precipitant 
ESTIGMFKNP
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
186S b 2.3 1n26_A hetero IL23A_HUMAN IL11_HUMAN PRL_HUMAN CLCF1_HUMAN IL6_HUMAN Q98823_HHV8 CSH_SHEEP IL12A_HUMAN IL27A_HUMAN CNTF_HUMAN 
TSVEKAPR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
187FEe 46.9 1n26_A hetero IL6_HUMAN PRL_HUMAN IL11_HUMAN IL6RB_HUMAN Q98823_HHV8 IL23A_HUMAN IL27A_HUMAN CLCF1_HUMAN IL6RB_MOUSE CSH_SHEEP CNTF_HUMAN homo 
LIYPWFTRSKQVMN
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
188YEb 0.9 1n26_A hetero IL11_HUMAN IL6_HUMAN IL6RB_HUMAN Q98823_HHV8 IL12A_HUMAN LIF_HUMAN CNTF_HUMAN CLCF1_HUMAN 
YPFHRL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
189IEe 23.4 1n26_A hetero IL6_HUMAN IL11_HUMAN IL6RB_HUMAN IL6RB_MOUSE LIF_HUMAN Q98823_HHV8 CNTF_HUMAN CLCF1_HUMAN otherpoly homo precipitant 
IKVFNTER
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
190VEb 0.0 1n26_A hetero IL11_HUMAN IL6_HUMAN LIF_HUMAN Q98823_HHV8 CNTF_HUMAN otherpoly precipitant 
VIENALTM
 MUTAGEN /note="V->G: 80% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="V->G: 80% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
191SEb 0.0 1n26_A hetero LIF_HUMAN IL6_HUMAN CNTF_HUMAN compound NAG otherpoly precipitant 
VTNKSWREGMQIL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
192MEb 0.0 1n26_A otherpoly 
VLITM
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
193CEb 6.0 1n26_A hetero LIF_HUMAN compound NAG otherpoly 
TVECNASKLM
 MUTAGEN /note="C->D: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" DISULFID ECO:0000269|PubMed:10066782" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->D: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" DISULFID ECO:0000269|PubMed:10066782" TOPO_DOM /note="Extracellular"
194VEb 0.0 1n26_A compound NAG otherpoly 
AVDEM
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
195AEb 3.6 1n26_A hetero compound NAG otherpoly 
ATEIVKNS
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
196SEb 0.0 1n26_A hetero compound NAG otherpoly 
NVIPAHS
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
197STb 10.9 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN compound NAG otherpoly 
HSAQPLERD
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
198VTe 24.0 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN 
LKVMGHIWA
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
199GEe 22.6 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN 
GLAKF
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
200SEe 28.1 1n26_A hetero I12R1_HUMAN DAPK1_HUMAN otherpoly precipitant 
SKNAYHITV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
201KEe 43.9 1n26_A hetero IL6RB_HUMAN compound NAG otherpoly precipitant 
SYKNATVQR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
202FEe 40.7 1n26_A hetero IL6RB_HUMAN precipitant 
SETYCRFVNAGL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
203S b 0.0 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE compound NAG otherpoly precipitant 
SNTLE
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
204K e 78.8 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE precipitant 
DYLEAHNTSRFK
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
205T e 32.5 1n26_A hetero IL6RB_MOUSE IL6RB_HUMAN IL11_HUMAN IL23R_HUMAN compound NAG otherpoly precipitant 
PTIDNVYFSHLE
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
206QEe 33.7 1n26_A 
SLVQIHERF
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
207TEe 55.2 1n26_A hetero PRL_HUMAN IL6RB_MOUSE IL6RB_HUMAN LIF_HUMAN CLCF1_HUMAN CSH_SHEEP 
TSYNRDPAGV
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
208FEb 9.6 1n26_A hetero 
FVLI
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
209QEe 34.2 1n26_A hetero PRL_HUMAN IL6_HUMAN IL11_HUMAN IL23A_HUMAN LIF_HUMAN IL27A_HUMAN CLCF1_HUMAN CSH_SHEEP IL12A_HUMAN CNTF_HUMAN compound CYS 
DFTQHISEY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
210GTb 1.2 1n26_A 
IVPSFELGTR
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
211CTe 22.7 1n26_A hetero IL23A_HUMAN PRL_HUMAN IL11_HUMAN I12A_HUMAN CSH_SHEEP IL12A_HUMAN CNTF_HUMAN CLCF1_HUMAN compound CYS metal NA 
RLTVFEQYC
 MUTAGEN /note="C->A: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->A: No change of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
212GTe 34.5 1n26_A hetero PRL_HUMAN IL23A_HUMAN IL6_HUMAN CSH_SHEEP IL27A_HUMAN metal NA 
DYSGKTHAL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
213I b 15.2 1n26_A homo precipitant 
IKVM
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
214LBb 0.6 1n26_A homo 
VIL
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
215Q e 29.1 1n26_A hetero IL6RA_HUMAN homo precipitant 
KQRETI
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
216P b 1.6 1n26_A precipitant 
PT
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
217D e 32.1 1n26_A hetero IL6RA_HUMAN homo precipitant 
DLEGHNST
 MUTAGEN /note="D->V: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" MUTAGEN /note="D->V: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular"
218P e 31.8 1n26_A hetero precipitant 
PS
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
219P b 4.7 1n26_A 
P
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
220AEe 22.3 1n26_A hetero compound NAG otherpoly precipitant 
KEVWAQHPYLRT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
221NEe 67.3 1n26_A compound NAG otherpoly 
NDGKSE
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-93, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-245 and A-350." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820" MUTAGEN /note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-93, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-245 and A-350." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
222IEb 17.5 1n26_A 
LVI
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
223TEe 42.2 1n26_A compound NAG 
QRTVSHEAK
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
224VEb 13.3 1n26_A 
LVIAM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
225TEe 46.1 1n26_A homo 
KESTRNI
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
226AEe 40.2 1n26_A metal NA homo precipitant 
PANSFLRQVCKT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
227V e 26.7 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN CNTFR_HUMAN metal NA homo 
VLKSIRQ
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
228ATe 58.9 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN CNTFR_HUMAN homo 
PNEKASGHRDMQYFILTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
229RTe 82.6 1n26_A hetero IL6RA_HUMAN I11RA_HUMAN CNTFR_HUMAN homo 
GKAEPSRNDV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
230N e 31.5 1n26_A hetero IL6RA_HUMAN I11RA_HUMAN CNTFR_HUMAN homo 
NSLEYKDRT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
231PTe 39.5 1n26_A metal NA homo 
PSDQVEGIK
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
232RTe 45.8 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN CNTFR_HUMAN 
RSDQMGTAL
 MUTAGEN /note="R->S: 30% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="R->S: 30% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
233W e 31.9 1n26_A hetero IL6RB_HUMAN IL6RA_HUMAN IL6RB_MOUSE I11RA_HUMAN CNTFR_HUMAN homo 
QRYWIHT
 MUTAGEN /note="W->Q: 30% decrease of ligand-binding and increase of IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="W->Q: 30% decrease of ligand-binding and increase of IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
234LEb 0.0 1n26_A 
LVCGM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
235SEe 25.8 1n26_A hetero IL6RA_HUMAN I11RA_HUMAN CNTFR_HUMAN homo precipitant 
EWKTSHRQV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
236VEb 0.0 1n26_A 
VLAI
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
237TEe 35.7 1n26_A hetero compound NAG precipitant 
STKQRALY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
238WEb 3.6 1n26_A hetero 
W
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
239QEe 46.4 1n26_A hetero compound NAG precipitant 
EQSTVRLF
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
240D e 30.9 1n26_A hetero compound NAG precipitant 
YPDNSTH
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
241P b 4.7 1n26_A compound NAG precipitant 
PEADGIKLNQRSTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
242HTe 99.0 1n26_A hetero Q98823_HHV8 PRL_HUMAN compound NAG precipitant 
DATSGPELRHIKNQV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
243STe 25.8 1n26_A hetero PRL_HUMAN CSH_SHEEP IL6RA_HUMAN compound NAG otherpoly homo 
STDALQIKMG
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
244W b 4.0 1n26_A hetero PRL_HUMAN CSH_SHEEP IL6RA_HUMAN homo 
WVALGTDEFIKNPQRS
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
245N e 61.8 1n26_A hetero PRL_HUMAN CLCF1_HUMAN CSH_SHEEP IL27A_HUMAN IL6RA_HUMAN compound NAG otherpoly homo 
SDRKLFNAEGIPQTV
 SITE /note="Not glycosylated" CARBOHYD /note="N-linked (GlcNAc...) asparagine" MUTAGEN /note="N->A: Slightly induces cleavage and sIL6R levels.No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-350." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" SITE /note="Not glycosylated" CARBOHYD /note="N-linked (GlcNAc...) asparagine" MUTAGEN /note="N->A: Slightly induces cleavage and sIL6R levels.No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-350." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
246S e 33.6 1n26_A hetero PRL_HUMAN IL6_HUMAN I12A_HUMAN CSH_SHEEP IL12A_HUMAN otherpoly homo precipitant 
TPSDRAGKQEILV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
247SSe 71.9 1n26_A hetero IL23A_HUMAN PRL_HUMAN IL6_HUMAN CLCF1_HUMAN Q98823_HHV8 CNTF_HUMAN I12A_HUMAN CSH_SHEEP IL12A_HUMAN IL27A_HUMAN homo 
SEGQFPY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
248FSe 78.5 1n26_A hetero IL23A_HUMAN IL6_HUMAN IL11_HUMAN PRL_HUMAN CLCF1_HUMAN Q98823_HHV8 IL27A_HUMAN CNTF_HUMAN I12A_HUMAN CSH_SHEEP LIF_HUMAN IL12A_HUMAN compound NAG homo 
YWSHILGFV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
249YSe 20.4 1n26_A hetero IL23A_HUMAN IL11_HUMAN IL6_HUMAN CLCF1_HUMAN IL27A_HUMAN I12A_HUMAN CSH_SHEEP IL12A_HUMAN CNTF_HUMAN IL6RA_HUMAN compound NAG homo 
FLYIN
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
250R e 43.9 1n26_A hetero IL6_HUMAN PRL_HUMAN IL6RA_HUMAN CLCF1_HUMAN I12A_HUMAN CSH_SHEEP CNTF_HUMAN homo 
SLTVRPIQHDM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
251LEb 1.1 1n26_A hetero 
LAIVM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
252REe 33.2 1n26_A hetero PRL_HUMAN CSH_SHEEP homo 
KTQLHIDEMR
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
253FEb 0.0 1n26_A hetero 
FYNS
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
254EEb 15.6 1n26_A hetero compound MNB homo 
ERCQFDSWGHNL
 MUTAGEN /note="E->A: 50% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="E->A: 50% decrease of ligand-binding and IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
255LEb 0.0 1n26_A 
LIV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
256REe 22.9 1n26_A hetero compound MNB precipitant 
RQ
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
257YEb 3.5 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN compound MAN 
YVLAIT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
258REb 18.6 1n26_A hetero 
RKQHY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
259AEb 3.6 1n26_A hetero I27RA_HUMAN 
PGRTVAEL
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
260ETe 43.2 1n26_A homo 
KEALVQIS
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
261RTe 66.0 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE 
DNKEQRIWGSYTH
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
262S e 45.3 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE 
ASKHELNDYT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
263KSe 91.0 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE 
RKEAPSTDL
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
264T e 68.8 1n26_A hetero IL6RB_HUMAN 
ETSALRKDQIG
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
265F e 26.8 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE precipitant 
WFKDEGLSRA
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
266TEe 39.6 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE precipitant 
ETKNSIQVHDW
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
267TEe 43.5 1n26_A hetero IL6RB_HUMAN homo precipitant 
TDMQEHSVLRI
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
268WEe 33.9 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE compound MNB precipitant 
VWHILRQFKNADEGPST
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
269MEe 42.0 1n26_A hetero IL6RB_MOUSE homo 
FPLNEMKHITQSVADGR
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
270V b 3.3 1n26_A hetero I27RA_HUMAN homo 
VALFPSDHCIT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
271KGe 63.2 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN homo 
ETAVGDQKSPHLM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
272DGe 80.2 1n26_A hetero I11RA_HUMAN IL23A_HUMAN IL6RA_HUMAN CNTFR_HUMAN I27RA_HUMAN CNTF_HUMAN homo 
DKGPNQTEVF
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
273LGb 16.9 1n26_A hetero IL6_HUMAN I27RA_HUMAN compound NAG precipitant 
TALIVKGNQSEDPR
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
274Q e 36.2 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN CNTFR_HUMAN IL27A_HUMAN homo precipitant 
QTKSRGEA
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
275HSe 27.2 1n26_A hetero I11RA_HUMAN CSH_SHEEP CNTFR_HUMAN homo precipitant 
TSGAHKLCENPY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
276HEe 42.4 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN CNTFR_HUMAN homo precipitant 
QSHAERTKVGM
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
277CEb 11.3 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN CNTFR_HUMAN precipitant 
CFTEHKLYSAIDGNPQRV
 MUTAGEN /note="C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
278VEe 27.3 1n26_A hetero I11RA_HUMAN IL6RA_HUMAN I27RA_HUMAN CNTFR_HUMAN homo precipitant 
VKTDRICFNL
 MUTAGEN /note="V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
279IEb 0.0 1n26_A homo 
ILVTHCMS
 MUTAGEN /note="I->D: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="I->D: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" I->N:(0.0 %):LP/P Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5) dbSNP:rs1689606 [MIM:618944]
280HSe 51.3 1n26_A hetero IL6RB_HUMAN I11RA_HUMAN IL6RA_HUMAN IL6RB_MOUSE CNTFR_HUMAN homo 
TLFKHQCRAVNS
 MUTAGEN /note="H->I: No change of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="H->I: No change of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" H->P:(0.0 %):US Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5) [MIM:618944]
281DSe 39.5 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN CNTFR_HUMAN homo 
DRSGHCKNT
 MUTAGEN /note="D->G: 70% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="D->G: 70% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
282A b 0.0 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN homo 
LAKCGST
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
283W e 57.8 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE homo 
KYVNRLDWQHAEFGIPST
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
284STe 53.9 1n26_A hetero IL6RB_HUMAN IL6RB_MOUSE I27RA_HUMAN 
PARSGKCDEFILNQTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
285GTe 45.2 1n26_A compound MAN 
GFRKSQADEILNPTV
 MUTAGEN /note="G->D: 80% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="G->D: 80% decrease of ligand-binding and no IL6 signaling." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
286L e 25.3 1n26_A hetero IL6RB_MOUSE IL6RB_HUMAN 
TKLQAMVIGFDENPRSY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
287R e 54.2 1n26_A compound MAN homo 
EKRPVTLNADFGIQSY
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
288HEb 1.0 1n26_A compound MAN homo 
YHAGLSDEFIKNPQRTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
289VEb 4.0 1n26_A 
VELIAFNSYDGKPRT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
290VEb 0.0 1n26_A 
VFIL
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
291QEb 11.2 1n26_A precipitant 
QRSE
 MUTAGEN /note="Q->K: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="Q->K: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
292LEb 0.0 1n26_A 
VILT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
293REe 26.1 1n26_A hetero compound MNB homo precipitant 
RSQAH
 MUTAGEN /note="R->G: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MUTAGEN /note="R->G: Complete loss of ligand-binding." DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
294AEb 0.0 1n26_A 
ACSG
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
295QEb 15.8 1n26_A hetero IL11_HUMAN I12A_HUMAN precipitant 
KRQIMNT
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
296EEb 0.5 1n26_A hetero IL23A_HUMAN IL11_HUMAN IL6_HUMAN CLCF1_HUMAN IL27A_HUMAN I12A_HUMAN IL12A_HUMAN homo 
DPEKLAGSTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
297ETb 15.1 1n26_A hetero IL23A_HUMAN IL6_HUMAN IL11_HUMAN PRL_HUMAN CLCF1_HUMAN IL27A_HUMAN I12A_HUMAN CSH_SHEEP CNTF_HUMAN homo 
RDEHFNPL
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
298FTe 75.1 1n26_A hetero IL23A_HUMAN IL6_HUMAN IL11_HUMAN IL27A_HUMAN I12A_HUMAN IL12A_HUMAN compound ATP homo 
LYFTDNSHAGEIKPQRV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
299GTe 58.3 1n26_A hetero IL23A_HUMAN IL11_HUMAN CLCF1_HUMAN I12A_HUMAN IL12A_HUMAN CNTF_HUMAN 
YDGESQAFIKLNPRTV
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
300QBb 19.4 1n26_A hetero IL23A_HUMAN PRL_HUMAN IL6_HUMAN CLCF1_HUMAN IL11_HUMAN IL27A_HUMAN I12A_HUMAN CSH_SHEEP homo 
HSKAINGPYLQ
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
301GSb 16.7 1n26_A hetero I12A_HUMAN 
GS
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
302E e 60.3 1n26_A hetero metal CL otherpoly precipitant 
SYTEFIQLR
 DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
303W b 19.1 1n26_A hetero compound MNB metal CL IOD homo precipitant 
WL
 MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
304S b 2.3 1n26_A precipitant 
SN
 MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
305E e 62.8 1n26_A precipitant 
EDANRTKV
 MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
306W e 20.3 1n26_A hetero compound MNB 
W
 MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
307S b 0.0 1n26_A 
SAT
 MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" MOTIF /note="WSXWS motif" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
308P e 82.9 1n26_A hetero 
PEVLQSA
 REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
309E e 58.3 1n26_A compound NAG 
EATP
 REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
310AEb 13.4 1n26_A compound NAG homo 
ASV
 REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
311MEe 36.7 1n26_A compound NAG homo 
TSWHAFLM
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
312GEb 16.7 1n26_A homo 
GASR
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
313T e 37.7 1n26_A homo 
TI
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
314P b 2.3 1n26_A 
PTQ
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
315W e 30.3 1n26_A homo 
WSYRADEGIKLPTV
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
316T e 49.4 1n26_A homo 
TESAI
 COMPBIAS /note="Polar residues" REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" DOMAIN /note="Fibronectin type-III 2" TOPO_DOM /note="Extracellular"
317E e 81.9 1n26_A homo 
EDGP
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
318S e137.5 1n26_A homo 
SRPETADGIKLV
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
319RSb 17.0 3l5h_A 
RKPEADGILSTV
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
320S e 39.3 3l5h_A 
ESAGTDIKLPRV
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
321P b 6.2 3l5h_A 
PTIRSADEGKLV
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
322P e 29.5 8qy6_F 
PI
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
323A---- 
AGL
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
324E---- 
EMQWAGLSDFIKNPRTVY
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
325N---- 
GLDTN
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
326E---- 
ENIQ
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
327V---- 
LVIP
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
328S---- 
WHPSGADEFIKLNQRTVY
 COMPBIAS /note="Polar residues" REGION /note="Disordered" TOPO_DOM /note="Extracellular" COMPBIAS /note="Polar residues" DISORDER predicted by DISOPRED REGION /note="Disordered" TOPO_DOM /note="Extracellular"
329T---- 
TNYLADEFGIKPQRSV
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
330P---- 
PMSADEFGIKLNQRTVY
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
331M---- 
TRDMAEFGIKLNPQSVY
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
332Q---- 
QW
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
333A---- 
AHVPS
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
334L---- 
ISEQPL
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
335T---- 
VDTG
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
336T---- 
ETYH
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
337N---- 
NDGP
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
338K---- 
QREKSY
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
339D---- 
QDVA
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
340D---- 
DQNL
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
341D---- 
EIHSD
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
342N---- 
SEAPDN
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
343I---- 
ILDAV
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
344L---- 
FQPVSL
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
345F---- 
WYAPSF
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
346R---- 
KRQEG
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
347D---- 
ENSPD
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
348S---- 
SD
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
349A---- 
ATLS
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
350N---- 
NEPQ
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" MUTAGEN /note="N->A: No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-245. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-245." TOPO_DOM /note="Extracellular" CARBOHYD /note="N-linked (GlcNAc...) asparagine" MUTAGEN /note="N->A: No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-245. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-245." DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
351A---- 
AP
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
352T---- 
THP
 CARBOHYD /note="O-linked (GlcNAc) threonine" MUTAGEN /note="T->A: No effect on IL6R signaling." TOPO_DOM /note="Extracellular" CARBOHYD /note="O-linked (GlcNAc) threonine" MUTAGEN /note="T->A: No effect on IL6R signaling." DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
353S---- 
SAP
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
354L---- 
RLV
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"
355P---- 
PL
 MUTAGEN /note="P->I,D: Reduces cleavage by ADAM17." SITE /note="Cleavage; by ADAM10 and ADAM17" MUTAGEN /note="PV->IE: Abolishes cleavage by ADAM17." TOPO_DOM /note="Extracellular" MUTAGEN /note="P->I,D: Reduces cleavage by ADAM17." SITE /note="Cleavage; by ADAM10 and ADAM17" MUTAGEN /note="PV->IE: Abolishes cleavage by ADAM17." TOPO_DOM /note="Extracellular"
356V---- 
VLS
 MUTAGEN /note="V->E,G: Abolishes cleavage by ADAM17." SITE /note="Cleavage; by ADAM10 and ADAM17" MUTAGEN /note="PV->IE: Abolishes cleavage by ADAM17." TOPO_DOM /note="Extracellular" MUTAGEN /note="V->E,G: Abolishes cleavage by ADAM17." DISORDER predicted by DISOPRED SITE /note="Cleavage; by ADAM10 and ADAM17" MUTAGEN /note="PV->IE: Abolishes cleavage by ADAM17." TOPO_DOM /note="Extracellular"
357Q---- 
QDL
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
358D---- 
DHQEG
 TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular" D->A:(0.0 %):LB/B - dbSNP:rs2228145
359S---- 
SPR
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
360S---- 
SDA
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
361S---- 
SP
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
362V---- 
VRIM
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
363P---- 
PES
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
364L---- 
LQ
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
365P---- 
PV
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"
366T---- 
TAL
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
367F---- 
FEV
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
368L---- 
LQ
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
369V---- 
V
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
370A---- 
AS
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
371G---- 
GLV
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
372G---- 
GA
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
373S---- 
SI
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
374L---- 
L
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
375A---- 
AGS
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
376F---- 
FI
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
377G---- 
GFL
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
378T---- 
TLGS
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
379L---- 
LC
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
380L---- 
LV
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
381C---- 
CAG
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
382I---- 
IVGL
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
383A---- 
AFG
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
384I---- 
ILV
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
385V---- 
IAGV
 TRANSMEM /note="Helical" TRANSMEM /note="Helical" V->I:(43.0 %):LB/B - dbSNP:rs2228146
386L---- 
LA
 TRANSMEM /note="Helical" TRANSMEM /note="Helical"
387R---- 
RGL
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
388F---- 
LFA
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
389K---- 
KLAGSDEFINPQRTVY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
390K---- 
KGQALSDEFINPRTVY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
391T---- 
TKLAGSDEFINPQRVY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
392W---- 
WG
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
393K---- 
KQLAEGSVDFINPRTCHMWY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
394L---- 
LS
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
395R---- 
RQE
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
396A---- 
AL
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
397L---- 
RLE
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
398K---- 
KR
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
399E---- 
EGS
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
400G---- 
GS
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
401K---- 
K
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
402T---- 
TD
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
403S---- 
GTNS
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
404M---- 
PSM
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
405H---- 
PHQ
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
406P---- 
PK
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
407P---- 
P
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
408Y---- 
YG
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
409S---- 
SFLP
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
410L---- 
L
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
411G---- 
GA
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
412Q---- 
PQS
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
413L---- 
LMV
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
414V---- 
IVLADEGKSTCFHMNPQRY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
415P---- 
PLADEGKSTVCFHIMNQRY
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
416E---- 
EAGLDKPSTVFINQRYCHMW
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
417R---- 
RAGLDEKPSTVFINQYCHMW
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
418P---- 
PAGLDEKSTVFINQRYCHMW
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
419R---- 
KR
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic"
420P---- 
PS
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
421T---- 
T
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
422P---- 
PF
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
423V---- 
VL
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
424L---- 
L
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
425V---- 
V
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
426P---- 
P
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
427L---- 
L
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
428I---- 
IL
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
429S---- 
STAEGLVDFHIKMNPQRY
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
430P---- 
PAEGLSVDFHIKMNQRTY
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
431P---- 
PSAEGLVDFHIKMNQRTY
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
432V---- 
VGAELSDFHIKMNPQRTY
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
433S---- 
ST
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
434P---- 
PH
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
435S---- 
NSH
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
436S---- 
S
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
437L---- 
LS
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
438G---- 
G
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
439S---- 
STAEGLVDFHIKMNPQRY
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
440D---- 
D
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
441N---- 
N
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
442T---- 
T
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
443S---- 
SGV
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
444S---- 
SRN
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
445H---- 
HN
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
446N---- 
SN
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
447R---- 
RC
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
448P---- 
PL
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
449D---- 
GDE
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
450A---- 
AV
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
451R---- 
R
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
452D---- 
DG
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
453P---- 
PA
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
454R---- 
QR
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
455S---- 
SC
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
456P---- 
P
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
457Y---- 
YN
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
458D---- 
D
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
459I---- 
NIV
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
460S---- 
S
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
461N---- 
N
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
462T---- 
RT
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
463D---- 
D
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
464Y---- 
Y
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
465F---- 
FL
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
466F---- 
F
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
467P---- 
P
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"
468R---- 
R
 REGION /note="Disordered" TOPO_DOM /note="Cytoplasmic" REGION /note="Disordered" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic"