Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 M -1 -1 -2 -3 -2 0 -2 -3 -2 1 2 -1 6 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0.38 0.01 2 L -1 -2 -3 -4 -1 -1 -3 -3 -2 1 3 -2 4 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 56 0 44 0 0 0 0 0 0 0 0.41 0.02 3 A 3 -1 0 -1 -1 -1 -1 0 -1 -2 -2 -1 -1 -2 -1 3 2 -3 -2 -1 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 14 0 0 0 0.35 0.02 4 V 0 -2 -1 -2 -1 -1 -1 -2 -2 1 0 -1 0 -2 -2 2 1 -3 -2 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 0 0 0 56 0.20 0.02 5 G 1 -2 0 -1 -2 -1 -1 4 -2 -3 -3 -1 -2 -3 -2 2 0 -3 -3 -3 0 0 0 0 0 0 0 56 0 0 0 0 0 0 0 44 0 0 0 0 0.60 0.02 6 C -1 -4 -3 -4 9 -3 -4 -3 -3 -1 -2 -3 -2 -3 -3 -1 -1 -3 -3 -1 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.42 0.04 7 A 2 -1 0 -1 -1 -1 -1 -1 -1 -2 -2 -1 -1 -2 -1 3 3 -3 -2 -1 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 27 0 0 0 0.34 0.02 8 L -1 -2 -2 -3 -2 -2 -3 3 -3 0 3 -2 1 -1 -3 -2 -2 -2 -2 0 0 0 0 0 0 0 0 35 0 0 65 0 0 0 0 0 0 0 0 0 0.35 0.03 9 L -1 -2 -2 -3 -1 -2 -2 -3 -2 1 4 -2 1 0 -2 1 -1 -2 -1 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 23 0 0 0 0 0.31 0.03 10 A 1 -2 -1 -2 -1 -1 -2 -2 -2 1 1 -1 0 -1 -2 1 2 -3 -2 2 9 0 0 0 0 0 0 0 0 0 16 0 0 0 0 12 28 0 0 35 0.19 0.03 11 A 2 2 -2 -3 -1 -1 -2 -2 -2 1 -1 0 0 -2 -2 -1 -1 -3 -2 3 29 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 47 0.23 0.06 12 L -1 -3 -4 -4 -2 -3 -3 -4 -3 1 4 -3 1 2 -3 -3 -1 -2 -1 2 0 0 0 0 0 0 0 0 0 0 66 0 0 10 0 0 0 0 0 24 0.43 0.06 13 L -2 -3 -4 -4 -2 -3 -3 -4 -3 1 5 -3 2 0 -3 -3 -2 -2 -1 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.67 0.09 14 A 4 -2 -2 -2 -1 -1 -2 -1 -2 0 -1 -1 -1 -2 -1 0 0 -3 -2 2 72 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 23 0.38 0.07 15 A 3 -1 -1 -1 -1 -1 -1 0 -2 -2 -2 -1 -2 -3 -1 3 0 -3 -2 -1 52 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 0 0 0 0 0.47 0.08 16 P -1 -3 -3 -2 -3 -2 -2 -3 -3 -1 -2 -2 -2 -3 7 -1 -1 -4 -3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 23 1.52 0.10 17 G 2 -2 -2 -3 -1 -2 -2 1 -3 2 2 -2 0 -1 -2 -1 -1 -3 -2 1 37 0 0 0 0 0 0 14 0 22 27 0 0 0 0 0 0 0 0 0 0.19 0.04 18 A 0 -2 -2 -3 -1 -1 -2 -3 -2 1 1 -2 4 -1 -2 -1 2 -3 -2 3 7 0 0 0 0 0 0 0 0 0 5 0 28 0 0 0 23 0 0 36 0.26 0.06 19 A 5 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -1 -3 -1 1 0 -3 -2 -1 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.64 0.10 20 L -2 -3 -4 -4 -2 -2 -3 -4 -3 3 3 -3 3 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 40 52 0 9 0 0 0 0 0 0 0 0.46 0.06 21 A 1 -3 -3 -4 -2 -2 -3 -2 -3 0 -1 -3 -1 0 -3 -2 -1 9 0 2 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 0 28 1.06 0.10 22 P -1 -1 -1 0 -3 1 4 -2 -1 -2 0 0 -1 -3 3 2 0 -3 -2 -2 0 0 0 0 0 0 48 0 0 0 14 0 0 0 14 23 0 0 0 0 0.41 0.06 23 R -1 1 -1 -2 -2 -1 -2 1 -2 0 2 -1 0 -1 -2 1 -1 -2 -2 -1 0 14 0 0 0 0 0 14 0 0 48 0 0 0 0 23 0 0 0 0 0.16 0.05 24 R 0 1 0 0 -3 1 3 0 -1 -3 -3 2 -2 -3 2 2 0 -3 -2 -2 0 7 0 0 0 0 34 7 0 0 0 14 0 0 10 28 0 0 0 0 0.37 0.05 25 C -1 0 -2 -2 8 -1 -1 -3 -2 -2 -2 4 -2 -3 -2 -1 -1 -3 -3 -2 0 0 0 0 52 0 0 0 0 0 0 48 0 0 0 0 0 0 0 0 0.84 0.11 26 P -1 1 3 3 -3 -1 0 -2 -1 -3 -3 0 -3 -4 5 0 -1 -4 -3 -3 0 13 21 27 0 0 0 0 0 0 0 0 0 0 32 7 0 0 0 0 0.67 0.06 27 A 1 -1 -2 -2 -2 3 -1 -2 -2 1 -1 0 0 -2 -2 -1 -1 -3 -2 3 20 0 0 0 0 25 0 0 0 0 0 7 0 0 0 0 0 0 0 48 0.21 0.06 28 Q 1 -2 -2 -3 -2 0 -2 -2 0 -1 1 -2 0 1 -2 -1 -1 0 5 -1 25 0 0 0 0 7 0 0 0 0 21 0 0 0 0 0 0 0 48 0 0.40 0.07 29 E -1 -2 -2 -1 -2 -1 2 -3 -2 1 -1 -2 -1 -1 -3 -2 -1 7 0 3 0 0 0 0 0 0 27 0 0 3 0 0 0 0 0 0 0 25 0 45 0.53 0.08 30 V 0 -3 -2 -3 -2 -3 -3 2 -3 2 0 -2 0 -2 -3 -2 -1 -3 -2 4 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 0 75 0.39 0.08 31 A 2 -1 -1 0 -3 0 4 -2 -1 -3 -3 0 -2 -3 4 0 -1 -3 -3 -2 27 0 0 0 0 0 48 0 0 0 0 0 0 0 25 0 0 0 0 0 0.62 0.07 32 R -1 0 1 -2 -2 0 -1 -3 -2 0 2 -1 0 -1 4 -1 -1 -3 -2 0 0 7 13 0 0 7 0 0 0 0 39 0 0 0 25 0 0 0 0 9 0.32 0.05 33 G -1 -2 0 5 -3 -1 0 4 -2 -4 -4 -1 -3 -4 -2 -1 -2 -4 -4 -4 0 0 0 55 0 0 0 45 0 0 0 0 0 0 0 0 0 0 0 0 0.81 0.08 34 V -2 -3 -3 -4 -2 -2 -3 -3 -3 0 -1 -3 -1 0 -3 -2 1 9 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 48 0 39 1.10 0.11 35 L -1 -1 -1 -2 -2 3 -1 -3 2 -1 0 -1 0 1 -2 0 -1 0 4 0 0 0 0 0 0 25 0 0 5 0 14 0 0 0 0 9 0 0 34 13 0.27 0.06 36 T -1 -2 -2 -2 -2 -2 -2 -3 -1 -2 -2 -2 -2 -1 5 0 3 -1 3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 38 0 41 0 21 0 0.78 0.11 37 S -1 -2 1 4 -2 -1 0 2 -2 -2 0 -1 -2 -3 -2 2 -1 -3 -3 -2 0 0 6 36 0 0 0 21 0 0 13 0 0 0 0 23 0 0 0 0 0.35 0.06 38 L 2 -1 -2 -2 -2 2 -1 -2 -2 0 3 -1 0 -1 -2 -1 -1 -2 -2 0 38 0 0 0 0 19 0 0 0 0 43 0 0 0 0 0 0 0 0 0 0.26 0.09 39 P -1 -3 -3 -3 -3 -2 -2 -3 -3 0 0 -2 -2 -3 7 -2 -2 -4 -3 -1 4 0 0 0 0 0 0 0 0 11 11 0 0 0 74 0 0 0 0 0 1.50 0.16 40 G -1 -3 -1 -2 -3 -3 -3 6 -3 -5 -5 -2 -4 -4 -3 -1 -2 -3 -4 -4 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.52 0.21 41 D 2 2 -1 1 -3 0 3 -2 -1 -3 -3 0 -2 -3 -2 2 -1 -3 -2 -2 21 16 0 4 0 0 39 0 0 0 0 0 0 0 0 20 0 0 0 0 0.42 0.11 42 S -1 1 -1 1 -2 -1 -1 -2 -2 -2 -1 0 2 -3 2 2 3 -3 -2 -1 0 8 0 8 0 0 0 0 0 0 0 4 14 0 11 24 32 0 0 0 0.31 0.10 43 V -1 -3 -4 -4 -2 -3 -3 -4 -4 2 1 -3 0 -1 -3 -3 -1 -4 -2 5 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 90 0.74 0.18 44 T -1 -1 1 -2 -2 1 -1 -3 -2 0 0 0 2 -2 -2 -1 2 -3 -2 3 0 0 10 0 0 10 0 0 0 0 0 6 11 0 0 0 25 0 0 39 0.23 0.10 45 L 0 -3 -4 -4 -2 -2 -3 -4 -3 2 4 -3 3 0 -3 -2 -2 -2 -2 0 10 0 0 0 0 0 0 0 0 10 72 0 8 0 0 0 0 0 0 0 0.53 0.12 46 T -1 -1 -1 -2 5 -2 -2 -3 -3 0 -2 0 -1 -3 -2 0 5 -3 -2 -1 0 2 0 0 16 0 0 0 0 9 0 8 0 0 0 0 65 0 0 0 0.58 0.16 47 C -2 -5 -4 -5 10 -4 -5 -4 -4 -2 -3 -4 -3 -4 -4 -2 -2 -4 -4 -2 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.38 0.30 48 P -1 -2 1 3 -3 -1 -1 0 0 -4 -4 -1 -3 -4 6 1 -1 -4 -3 -3 0 0 10 27 0 0 0 8 2 0 0 0 0 0 44 10 0 0 0 0 0.91 0.13 49 G 0 -2 -1 -1 -2 -1 -2 4 -2 -2 -2 -1 -2 -3 -2 1 3 -3 -2 -2 1 0 0 1 0 0 1 44 0 0 1 1 0 0 1 9 39 0 0 1 0.55 0.11 50 V 1 -1 -1 -1 -1 -1 -1 0 -1 0 0 0 1 -1 1 0 0 -2 -1 1 15 2 1 2 1 1 2 7 1 2 3 10 9 1 8 10 2 0 1 23 0.07 0.03 51 E -1 -1 1 2 -2 1 3 -1 -1 -2 -2 0 -1 -2 -1 1 2 -2 -1 -1 2 2 5 10 1 1 37 2 1 2 3 2 1 1 2 9 17 0 1 2 0.27 0.05 52 P 2 -1 -1 -1 -2 0 1 -1 -1 -2 -2 -1 -2 -2 5 0 -1 4 -1 -1 26 1 1 1 0 1 16 2 1 1 2 1 1 1 31 2 1 8 1 2 0.52 0.07 53 E 0 -1 0 3 -2 0 4 1 -1 -2 -2 0 -2 -3 -1 0 -1 -2 -2 -2 10 1 1 21 0 1 42 12 0 1 2 1 0 1 1 1 1 0 1 1 0.39 0.07 54 D 1 -1 0 3 -2 0 2 2 -1 -3 -3 -1 -2 -3 -1 0 -1 -3 -2 -2 12 1 1 30 0 1 23 22 0 1 2 1 0 1 1 1 1 0 1 1 0.38 0.07 55 N -1 -1 3 3 -1 0 0 2 0 -2 -2 0 -1 -2 -1 0 0 -1 -1 -1 4 2 19 24 1 2 3 17 1 2 4 3 1 2 2 3 3 1 2 3 0.21 0.03 56 A 2 -1 -1 -1 -1 -1 -1 2 -1 0 -1 -1 -1 -1 -1 0 1 -1 -1 0 24 2 2 2 1 2 2 24 1 5 4 2 1 2 2 3 13 1 1 7 0.14 0.02 57 T 1 -1 0 -1 -1 0 0 -1 -1 -1 -1 0 -1 -1 3 0 2 -1 -1 -1 12 3 2 3 1 2 3 4 1 3 5 3 1 2 19 4 24 1 2 4 0.21 0.02 58 V -1 -3 -3 -3 -1 -2 -3 -3 -3 4 1 -2 1 -1 -2 -2 -1 -2 -1 3 1 1 1 1 0 1 1 1 0 50 11 1 0 0 1 1 1 0 0 29 0.41 0.09 59 H -1 -1 0 -1 -2 -1 -1 -2 4 0 -1 -1 -1 -1 -2 2 3 -2 2 -1 1 1 1 1 0 1 1 1 18 8 1 1 0 0 1 17 37 0 10 1 0.29 0.09 60 W -3 -3 -4 -4 -3 -3 -3 -3 -3 -3 -3 -3 -2 0 -4 -3 -3 11 1 -3 1 0 0 1 0 0 1 1 0 0 1 1 0 0 1 1 1 90 0 1 2.91 0.29 61 V 0 -1 -1 -1 -1 -1 -1 -1 -1 0 0 -1 0 1 -1 0 3 -1 -1 1 3 2 2 2 1 2 3 3 1 2 7 2 1 7 2 3 35 1 1 20 0.11 0.04 62 L -1 0 -1 -1 -1 -1 -1 -1 -1 0 2 -1 0 1 -1 0 -1 0 2 0 4 8 2 3 1 2 3 3 1 2 32 3 1 9 2 7 3 1 10 3 0.06 0.02 63 R -1 2 1 2 -1 1 0 -1 0 -1 0 0 0 -1 -1 0 0 -1 -1 -1 4 18 12 15 1 6 3 4 1 2 14 3 1 2 3 3 3 1 2 3 0.09 0.02 64 K 0 0 1 1 -1 1 1 2 0 -1 -1 2 -1 -1 0 0 0 -1 -1 -1 4 2 7 10 1 5 9 17 1 2 4 21 1 2 3 3 3 1 2 3 0.12 0.01 65 P 0 1 0 -1 -1 1 0 1 -1 -1 -1 0 -1 -2 4 0 0 -1 -1 -1 4 12 6 3 1 7 3 11 1 2 4 3 1 2 26 6 3 1 2 3 0.29 0.02 66 A 1 2 0 1 -1 0 0 0 -1 -1 -1 1 -1 -2 -1 0 0 -1 -1 0 15 22 2 13 1 2 3 6 1 2 4 8 1 2 2 7 2 1 1 7 0.11 0.02 67 A 0 -1 1 -1 -2 1 1 -2 -1 -1 0 -1 -1 -2 -1 2 3 -2 -2 -1 5 0 8 0 0 10 7 1 0 0 16 0 0 0 0 20 29 0 0 0 0.20 0.07 68 G 0 0 -1 -2 -2 -1 -2 4 -2 -2 -1 -1 -2 -3 2 2 -1 -3 -3 -2 4 7 0 0 0 0 0 39 0 0 6 0 0 0 10 30 0 0 0 3 0.40 0.09 69 S 0 -1 0 3 3 1 0 -1 -1 -2 -1 -1 -1 -2 -1 2 1 -3 -2 -2 5 1 0 24 10 6 4 1 0 1 8 1 0 0 1 28 8 0 0 1 0.24 0.07 70 H -1 0 0 1 -3 4 2 0 4 -2 -1 0 -1 -2 0 -1 -1 -2 -1 -2 1 4 0 8 0 36 11 6 16 1 8 1 0 0 5 1 1 0 0 1 0.34 0.09 71 P 0 -1 0 0 -2 1 -1 -2 -1 0 0 0 -1 -1 2 2 0 -2 1 -1 1 1 5 5 0 8 1 1 0 8 11 4 0 0 10 34 1 0 10 1 0.15 0.06 72 S 0 1 1 2 -2 -1 0 1 -1 -3 -3 -1 -2 -3 -1 4 0 -3 -2 -2 1 9 3 14 0 0 1 12 0 1 1 1 0 0 1 54 1 0 0 1 0.38 0.10 73 R -1 3 -1 2 -3 1 3 -2 -1 -3 -2 1 -2 -3 1 -1 -1 -3 -2 -2 1 29 1 12 0 1 38 1 0 1 1 1 0 1 8 1 1 0 1 1 0.46 0.09 74 W -1 1 -1 0 -2 -1 -1 -2 -2 1 0 -1 0 -1 0 0 -1 5 -1 2 1 11 1 8 0 1 1 1 0 4 11 1 0 1 5 9 1 13 1 30 0.18 0.05 75 A 1 -2 1 -2 -2 -1 -2 -2 2 0 2 -2 0 -1 -2 1 1 -3 -1 0 16 0 9 0 0 0 0 0 7 0 39 0 0 0 0 11 8 0 0 8 0.14 0.07 76 G -1 -2 1 -2 -3 -2 -2 5 -2 -3 -1 0 -2 -3 -2 -1 0 -3 -3 -3 0 0 9 0 0 0 0 64 0 0 7 9 0 0 0 0 8 0 0 0 0.68 0.13 77 M 0 -2 1 -2 -2 -1 -2 -2 -2 0 1 -1 1 -2 -2 3 2 -3 -2 1 0 0 7 0 0 0 0 0 0 0 23 0 4 0 0 34 19 0 0 12 0.23 0.10 78 G -1 -3 -1 -2 -3 -2 -3 6 -3 -1 -4 0 -3 -4 -3 0 -2 -3 -4 -3 0 0 0 0 0 0 0 79 0 8 0 6 0 0 0 8 0 0 0 0 1.03 0.20 79 R -1 1 1 -1 -3 0 -1 -2 3 -2 -1 3 1 -2 -2 1 0 -2 1 -2 0 6 7 0 0 0 0 0 12 0 8 33 8 0 0 11 8 0 6 0 0.24 0.11 80 R -1 3 -1 -2 -2 1 0 -3 -1 -1 0 0 -1 -1 -2 0 3 -2 2 0 0 23 0 0 0 7 4 0 0 0 8 0 0 0 0 0 40 0 12 6 0.33 0.14 81 L 0 -2 -4 -4 -2 -2 -3 -4 -3 0 4 0 1 0 -3 -3 -2 -2 1 0 7 0 0 0 0 0 0 0 0 0 74 7 0 0 0 0 0 0 8 5 0.54 0.19 82 L -1 -2 -2 -3 -2 0 -2 -3 -3 2 1 -2 0 1 -3 -1 3 -3 -1 3 0 0 0 0 0 5 0 0 0 15 16 0 0 7 0 0 28 0 0 30 0.31 0.13 83 L -2 -3 -3 0 -2 -3 -3 -4 -4 3 3 -3 1 -1 -3 -3 -2 -3 -2 2 0 0 0 7 0 0 0 0 0 26 49 0 0 0 0 0 0 0 0 18 0.49 0.15 84 R 0 4 1 -2 -3 4 0 -2 0 -3 -2 2 -2 -4 -2 -1 -2 -3 -2 -3 12 35 7 0 0 34 0 0 2 0 3 8 0 0 0 0 0 0 0 0 0.57 0.18 85 S 0 0 0 -1 2 1 -1 0 -2 0 -1 -1 -1 -2 -2 1 -1 -3 -2 3 7 7 5 3 5 12 0 7 0 0 0 0 0 0 0 16 0 0 0 39 0.16 0.12 86 V 0 1 -2 -2 -2 -1 -1 -3 -2 1 0 3 -1 -2 -2 0 -1 -3 -2 3 4 8 0 0 0 0 0 0 0 7 7 31 0 0 0 7 0 0 0 37 0.25 0.14 87 Q -2 1 1 3 2 2 4 -3 -1 -3 -2 1 -2 -4 -2 -1 -1 -4 -3 -3 0 7 7 17 8 11 38 0 0 0 5 8 0 0 0 0 0 0 0 0 0.47 0.14 88 L 0 -2 -2 -3 -2 0 -2 -3 -2 0 1 -2 1 5 -3 0 0 -1 1 0 8 0 0 0 0 7 0 0 0 0 20 0 4 38 0 12 4 0 0 3 0.30 0.12 89 H 0 0 0 -1 -2 1 1 2 2 -2 -1 -1 -1 -2 1 1 1 -3 -2 -2 2 3 3 0 0 7 13 25 9 0 8 0 0 0 5 12 9 0 0 0 0.21 0.08 90 D -2 -2 1 6 -4 0 0 -2 4 -4 -4 -2 -4 -4 -3 0 -2 -5 -3 -4 0 0 3 72 0 5 0 0 13 0 0 0 0 0 0 7 0 0 0 0 1.10 0.25 91 S 2 -2 -1 -1 -2 -1 1 2 -2 -1 -2 -1 -2 -3 1 2 1 -3 -3 -1 31 0 0 0 0 0 12 14 0 5 0 0 0 0 8 24 6 0 0 0 0.32 0.12 92 G -1 -3 -1 0 -4 -3 -3 6 2 -5 -5 -3 -4 -4 -3 -1 -3 -4 -3 -4 0 0 0 7 0 0 0 86 7 0 0 0 0 0 0 0 0 0 0 0 1.33 0.26 93 N -1 -1 2 0 -3 4 2 -1 2 -3 -1 0 -1 -2 -2 0 1 0 1 -2 0 0 12 3 0 30 12 2 6 0 7 0 0 0 0 6 12 2 8 0 0.30 0.13 94 Y -3 -3 -4 -5 -4 -3 -4 -4 0 -2 1 -3 -2 1 -4 -3 -3 6 8 -2 0 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 12 75 0 1.51 0.33 95 S 0 -2 1 -2 -2 -1 -2 -2 -2 0 0 -2 -1 -2 -2 2 4 -3 -2 1 7 0 6 0 0 0 0 0 0 4 6 0 0 0 0 22 40 0 0 15 0.34 0.15 96 C -2 -4 -3 -3 10 -3 1 -4 -4 -3 -3 -3 -3 -4 -4 0 -2 -4 -4 -2 0 0 0 0 82 0 12 0 0 0 0 0 0 0 0 6 0 0 0 0 1.96 0.37 97 Y -2 2 -1 -2 -3 2 -1 -3 6 -3 -3 -1 -2 2 -3 -1 0 5 3 -3 0 12 0 0 0 11 0 0 34 0 0 0 0 10 0 3 8 12 10 0 0.66 0.19 98 R 0 2 -1 -1 -2 1 0 -2 2 -2 -1 3 -1 -3 -2 1 2 -3 -2 -1 4 13 0 0 0 3 5 0 7 0 6 29 0 0 0 12 16 0 0 6 0.24 0.10 99 A 0 -2 0 2 -2 -2 -1 4 -2 -2 0 -2 -2 -3 -2 2 1 -3 -3 -2 2 0 3 13 0 0 0 41 0 0 12 0 0 0 0 19 10 0 0 0 0.41 0.13 100 G -1 -3 -1 0 -4 -2 1 5 -3 -4 -4 -2 -3 -4 -3 0 -2 4 -3 -4 0 0 0 6 0 0 12 70 0 0 0 0 0 0 0 5 0 7 0 0 0.98 0.22 101 R 0 2 -1 -1 -3 0 2 -3 4 -2 -1 0 -1 1 -2 0 -1 -3 -1 0 6 15 0 0 0 0 25 0 18 0 6 5 0 8 0 7 0 0 0 11 0.23 0.11 102 P 0 -2 -2 0 -2 -2 -2 -3 -3 1 1 -2 0 -1 4 0 0 -3 -2 2 6 0 0 8 0 0 0 0 0 7 20 0 0 3 22 5 7 0 0 21 0.28 0.09 103 A 0 0 -2 -3 -2 -2 -2 1 -3 0 3 -1 0 -1 -3 -2 0 -3 -2 1 5 6 0 0 0 0 0 12 0 0 51 5 0 0 0 0 8 0 0 11 0.23 0.12 104 G 1 -2 -1 -2 2 -1 -2 3 2 0 -2 -2 -2 -2 -2 3 1 -3 0 -2 7 0 0 0 5 0 0 27 6 8 0 0 0 0 0 33 7 0 5 0 0.30 0.13 105 T -1 1 -1 -2 -2 2 -1 1 3 0 -2 -1 1 -2 -2 0 2 -3 -1 -1 0 11 0 0 0 16 0 12 14 8 0 0 8 0 0 5 23 0 0 0 0.23 0.13 106 V -1 -2 -2 -2 -2 -2 -2 -3 -3 2 -1 -2 1 -2 -2 3 1 -3 -2 4 0 0 0 0 0 0 0 0 0 12 0 0 3 0 0 31 10 0 0 42 0.39 0.19 107 H -1 1 1 -1 2 0 0 0 2 -1 1 -1 -1 -1 0 -1 2 -2 0 -1 0 8 7 2 6 2 9 6 7 0 22 0 0 2 5 0 22 0 4 0 0.10 0.10 108 L -3 -3 -5 -5 -2 -3 -4 -5 -4 3 5 -4 2 -1 -4 -4 -2 -3 -2 0 0 0 0 0 0 0 0 0 0 22 74 0 4 0 0 0 0 0 0 0 0.87 0.26 109 L -1 0 -2 -3 -2 0 -2 -3 2 1 3 0 0 1 -3 -1 -1 -2 1 -1 3 4 0 0 0 3 0 0 8 6 52 7 0 4 0 4 3 0 6 0 0.27 0.14 110 V -1 -3 -3 -3 -2 -2 -3 -2 -3 2 3 -2 0 -1 -3 1 0 -3 -2 3 0 0 0 0 0 0 0 3 0 6 32 2 0 0 0 14 2 0 0 41 0.37 0.18 111 D -2 -2 -1 4 -4 2 0 4 0 -4 -4 -1 -3 -4 -3 -1 -2 -4 -4 -4 0 0 0 33 0 12 3 46 3 0 0 2 0 0 0 0 0 0 0 0 0.82 0.24 112 V -1 -3 -3 -3 -2 -2 -3 -3 -3 3 2 -2 0 1 -3 0 -1 -2 1 3 2 0 0 0 0 2 0 0 0 22 22 2 0 7 0 9 0 0 7 27 0.30 0.14 113 P -1 -3 -3 0 -4 -3 -2 -3 -3 -3 0 -1 -2 -1 7 -2 -2 -4 -3 -1 6 0 0 7 0 0 0 0 0 0 12 3 0 4 64 0 0 0 0 4 1.33 0.32 114 P -2 -1 -3 -3 -5 1 -2 -2 -3 -4 -4 2 -4 -5 7 -2 -3 -5 -4 -4 0 1 0 0 0 7 0 2 0 0 0 18 0 0 71 0 0 0 0 0 1.76 0.39 115 E 0 0 1 3 -4 0 4 1 -2 -4 -4 2 -3 -4 -2 -1 -2 -4 -3 -3 9 5 5 20 0 0 36 10 0 0 0 15 0 0 0 0 0 0 0 0 0.52 0.19 116 E -2 2 -1 1 -4 4 3 -3 -1 -2 -3 3 -2 -4 1 -1 -2 -4 -3 -3 0 9 0 6 0 25 22 0 0 4 0 29 0 0 6 0 0 0 0 0 0.59 0.22 117 P -3 -3 -3 -3 -5 -3 -3 -4 -4 -5 -5 1 -4 -5 8 -2 0 -5 -5 -4 0 0 0 0 0 0 0 0 0 0 0 11 0 0 82 2 5 0 0 0 2.15 0.47 118 Q -2 2 2 -1 -4 2 3 -2 -1 -2 -3 3 -2 0 -2 -1 -1 -3 -2 0 0 13 11 0 0 12 24 2 0 0 0 21 0 6 0 0 2 0 0 10 0.36 0.18 119 L -2 -3 -1 -4 -2 -3 -4 -4 -4 3 4 -3 0 -1 -4 -3 -2 -3 -2 2 0 0 5 0 0 0 0 0 0 22 55 0 0 0 0 0 0 0 0 18 0.66 0.24 120 S -1 0 -1 -2 -3 0 -1 -2 -1 0 -2 2 0 -1 -2 4 2 -3 -2 -1 0 3 0 0 0 4 0 0 1 8 0 21 3 4 0 43 11 0 0 1 0.38 0.23 121 C -2 -1 -4 -5 10 -4 -4 -4 -4 -3 -3 1 -3 -4 -4 -3 0 -4 -4 0 0 3 0 0 74 0 0 0 0 0 0 11 0 0 0 0 5 0 0 6 1.97 0.48 122 F -2 1 -2 -2 4 -1 2 -3 -2 1 -1 -1 0 2 -2 -2 -1 3 -1 0 1 13 1 1 14 1 21 1 0 15 1 1 3 14 1 1 1 5 1 5 0.24 0.13 123 R 2 3 -2 -2 -3 3 -1 -2 -2 -2 -1 0 -2 -3 -2 2 -1 -4 -3 0 24 24 0 0 0 18 0 0 0 0 5 0 0 0 0 19 0 0 0 10 0.37 0.21 124 K 0 1 3 -1 -3 0 0 -2 -2 -4 -4 4 -3 -4 -2 2 -1 -4 -3 -3 9 4 17 0 0 0 4 0 0 0 0 46 0 0 0 20 0 0 0 0 0.61 0.26 125 S -1 0 3 1 2 -1 1 1 -2 -2 -2 -1 -2 -3 2 0 1 -4 -3 -1 3 4 25 6 5 0 10 10 0 0 3 0 0 0 12 6 11 0 0 6 0.27 0.13 126 P -2 -2 -1 1 -4 -1 3 1 -1 -3 -3 -2 -3 -1 1 0 -2 -1 5 -3 0 0 2 10 0 0 24 14 0 0 0 0 0 0 8 7 0 0 32 0 0.51 0.22 127 L 1 0 0 -2 -2 0 -1 -2 -1 -2 0 2 1 -1 2 2 -1 -2 1 -2 12 5 4 1 0 2 1 1 0 0 9 16 5 0 12 20 1 0 9 1 0.20 0.12 128 S 0 -1 -1 -1 -3 -1 3 3 -2 -1 -3 2 -2 -4 -2 1 -2 -4 -3 -1 5 0 0 0 0 0 24 30 0 4 0 22 0 0 0 10 0 0 0 4 0.42 0.20 129 N -1 2 4 0 -3 -1 -1 0 2 -3 -3 0 -2 -4 -3 1 3 -4 -2 -3 4 13 28 5 0 0 0 7 7 0 0 3 0 0 0 6 26 0 0 0 0.44 0.20 130 V -1 -4 -4 -5 -3 -4 -4 -4 -3 1 0 -4 3 6 -4 -3 -3 -1 0 2 4 0 0 0 0 0 0 0 0 8 5 0 10 55 0 0 0 0 0 18 0.90 0.30 131 V 0 -1 -1 0 -2 -2 -2 -2 -2 -1 -1 -2 -2 -1 -2 1 5 -3 1 -1 8 3 0 4 0 0 0 2 0 2 6 0 0 2 0 12 50 0 7 2 0.44 0.23 132 C -3 -6 -5 -6 11 -5 -6 -5 -5 -3 -1 -5 -3 -4 -5 -3 -3 -5 -5 -3 0 0 0 0 94 0 0 0 0 0 6 0 0 0 0 0 0 0 0 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1 3 4 0 1 4 0.34 0.12 160 D -1 -2 0 4 -2 -1 1 0 -2 0 -1 0 -2 -2 -2 1 1 1 -2 0 1 1 0 32 0 0 10 5 0 5 4 6 0 0 1 9 14 3 0 7 0.27 0.13 161 F -1 -1 -1 -1 -2 1 -1 -2 3 -1 0 -1 -1 4 -2 -1 -1 4 3 -1 4 3 3 2 0 9 1 1 12 2 8 3 0 23 1 4 2 7 13 3 0.28 0.12 162 Q -1 2 0 -1 -2 3 0 -1 -1 1 -1 0 0 -2 1 0 0 -2 -2 0 4 18 3 1 0 23 3 3 0 12 1 3 2 1 8 6 7 0 0 4 0.20 0.11 163 E -1 0 1 1 -2 0 3 -2 3 -2 -2 2 -2 -2 -1 0 -1 3 1 -1 2 4 6 6 0 1 26 1 9 1 2 14 0 1 1 8 1 5 6 6 0.25 0.10 164 P -1 0 0 -1 -2 2 2 -2 -1 -2 -2 0 -2 -1 4 0 0 -2 2 -2 2 4 4 1 0 11 16 2 1 1 2 4 1 1 22 9 6 0 11 2 0.35 0.11 165 C -1 -1 0 -3 9 -2 -3 -3 -3 -2 -2 -1 -2 -1 -3 0 -2 0 -2 -1 1 4 5 1 60 1 1 1 0 1 1 5 0 3 1 7 1 1 1 4 1.22 0.30 166 Q -2 1 0 0 1 2 2 -2 -1 -3 -3 3 -2 -1 3 -1 -2 -3 -2 -3 1 4 2 3 3 14 19 1 0 1 1 25 0 4 19 1 1 0 0 1 0.47 0.17 167 Y -2 0 -1 3 -3 -1 0 -3 2 -1 -1 -1 -2 0 -2 -1 -1 -1 5 -2 1 7 0 25 0 0 6 1 5 5 5 1 0 0 1 4 4 0 33 1 0.44 0.19 168 S -1 -1 -1 0 0 0 -1 -2 -1 -1 -2 1 -2 -1 1 2 1 -1 4 -2 0 2 0 4 3 5 3 0 0 3 1 9 0 0 6 25 11 0 27 0 0.32 0.18 169 Q -2 1 0 0 2 2 -1 -3 3 0 0 1 -1 0 -3 -2 -1 -3 -1 2 0 7 4 5 6 16 0 0 10 2 8 12 0 6 0 0 0 0 0 23 0.16 0.14 170 E 0 1 -1 1 -3 1 3 -1 -2 -3 -3 1 -2 -3 1 0 3 -3 -1 -2 5 7 0 6 0 4 29 4 0 0 0 6 0 0 7 3 25 0 3 0 0.36 0.18 171 S 1 -2 -2 -1 5 0 -2 0 0 -1 0 -1 -1 -2 0 0 0 -3 0 0 16 0 0 3 23 6 0 7 2 0 14 3 0 0 4 9 4 0 5 5 0.24 0.14 172 Q -1 -1 0 0 -3 4 0 2 0 -3 0 1 -2 -3 -2 1 0 -3 -3 -3 0 0 4 6 0 29 3 21 3 0 11 7 0 0 0 10 8 0 0 0 0.32 0.18 173 K -1 1 -1 1 1 0 3 -1 -2 -3 -2 1 -2 -4 4 1 -1 -4 -3 -3 0 8 0 7 4 0 23 3 0 0 3 10 0 0 25 15 0 0 0 0 0.50 0.18 174 F -1 -2 3 0 -2 -1 -1 1 1 -1 0 -1 -1 2 -2 -1 1 -2 0 -2 1 1 24 6 0 1 1 13 5 1 15 1 0 14 1 1 11 0 3 1 0.19 0.12 175 S 0 1 -1 -2 -2 -1 -1 1 -2 -3 -3 1 -2 -1 -2 5 0 -3 -2 -3 1 8 0 1 0 0 1 10 0 1 1 7 0 2 1 63 2 0 0 1 0.59 0.25 176 C -1 -3 -2 -3 9 -2 -3 -2 -3 1 -1 -2 -1 -2 -2 -2 -1 -2 -2 0 5 1 1 1 60 1 2 2 1 8 6 1 1 1 1 2 2 0 1 4 1.19 0.25 177 Q -1 -1 1 1 -2 1 0 -2 3 -1 -1 -1 1 0 -1 -1 1 -1 2 0 5 1 8 10 1 9 4 2 12 1 2 2 7 4 1 2 9 0 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0.49 0.24 187 F -2 -1 -2 -3 -2 -1 -2 -3 -2 1 2 -1 1 1 1 -1 0 4 3 0 0 4 2 0 0 3 0 0 0 13 27 3 2 5 9 4 5 6 13 3 0.22 0.12 188 Y -3 0 -3 -4 -4 -3 -3 -4 3 -3 -2 -3 -3 2 4 -3 -3 -1 7 -3 0 6 0 0 0 0 0 0 6 0 3 0 0 7 22 0 0 0 56 0 1.25 0.37 189 I -2 -1 0 -3 -3 -2 -1 -4 -3 4 0 1 -1 1 -3 -2 0 -3 -2 2 0 3 7 0 0 0 5 0 0 48 0 14 0 7 0 0 6 0 0 11 0.36 0.21 190 V 0 -2 0 -2 -2 -2 2 -3 -3 3 0 -2 0 -2 -3 -2 0 -3 -2 3 5 0 6 0 0 0 18 0 0 22 5 0 2 0 0 0 3 0 0 37 0.32 0.17 191 S -1 0 2 -2 -2 0 -1 -1 -2 -1 -1 1 0 -2 -3 1 2 4 -2 2 0 4 14 0 0 2 3 3 0 1 1 10 2 0 0 10 19 8 0 23 0.23 0.16 192 M -2 -4 -4 -4 -2 -3 -4 -4 -4 2 2 -3 2 -2 -4 -3 0 -4 -2 5 0 0 0 0 0 0 0 0 0 11 21 0 5 0 0 0 6 0 0 57 0.69 0.26 193 C 0 -2 1 -1 3 -1 2 -3 -2 -1 -1 -1 -1 -3 -2 0 3 -4 -3 2 6 0 8 0 8 0 20 0 0 0 2 2 1 0 0 5 24 0 0 24 0.28 0.18 194 V 3 -3 -2 1 -2 -2 1 -2 -3 -1 -2 -2 1 -3 -3 -1 -1 -4 -3 3 44 0 0 11 0 0 11 0 0 0 0 0 5 0 0 0 0 0 0 28 0.42 0.24 195 A 2 -2 0 -1 -2 -1 1 -2 -2 1 -2 0 -1 -3 -2 0 2 -4 -3 1 28 0 6 0 0 0 15 0 0 11 0 6 0 0 0 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0 -2 -1 -2 -2 2 -1 -3 -2 0 2 -3 -2 -2 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0.52 0.01 463 D -2 -2 1 6 -4 0 2 -1 -1 -3 -4 -1 -3 -4 -2 0 -1 -4 -3 -3 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.95 0.01 464 Y -2 -2 -2 -3 -3 -2 -2 -3 2 -1 -1 -2 -1 3 -3 -2 -2 2 7 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0.90 0.01 465 F -2 -3 -3 -4 -2 -3 -3 -3 -2 1 3 -3 1 5 -3 -2 -2 0 2 0 0 0 0 0 0 0 0 0 0 0 48 0 0 52 0 0 0 0 0 0 0.44 0.00 466 F -2 -3 -3 -4 -2 -3 -3 -3 -1 0 0 -3 0 6 -4 -2 -2 1 3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0.77 0.01 467 P -1 -2 -2 -2 -3 -1 -1 -2 -2 -3 -3 -1 -3 -4 8 -1 -1 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.06 0.01 468 R -2 6 0 -2 -4 1 0 -2 0 -3 -2 2 -1 -3 -2 -1 -1 -3 -2 -3 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.01 K Lambda Standard Ungapped 0.1317 0.3174 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1317 0.3174 PSI Gapped 0.0410 0.2670