Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2692367 | 631 | 35 | P17405(ASM_HUMAN) | RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor; |
QUERYSEQ |
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR SVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYEN TLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS ARADSPALCRHLMPDGSLPEAQSLWPRPLFC |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
1 | M | - | - | - | - | M |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
2 | P | - | - | - | - | P |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
3 | R | - | - | - | - | RH |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
4 | Y | - | - | - | - | HY |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
5 | G | - | - | - | - | GR |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
6 | A | - | - | - | - | AV |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
7 | S | - | - | - | - | S |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
8 | L | - | - | - | - | SLP |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
9 | R | - | - | - | - | GR |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
10 | Q | - | - | - | - | Q |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
11 | S | - | - | - | - | DGS |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
12 | C | - | - | - | - | HCL |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
13 | P | - | - | - | - | PL |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
14 | R | - | - | - | - | R |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
15 | S | - | - | - | - | SA |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
16 | G | - | - | - | - | G |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
17 | R | - | - | - | - | RW |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
18 | E | - | - | - | - | E |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
19 | Q | - | - | - | - | Q |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
20 | G | - | - | - | - | RAG |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
21 | Q | - | - | - | - | LQS |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
22 | D | - | - | - | - | DE |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
23 | G | - | - | - | - | RG |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
24 | T | - | - | - | - | ST |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | ||
25 | A | - | - | - | - | LA |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | ||
26 | G | - | - | - | - | GP |
SIGNAL SIGNAL | ||
27 | A | - | - | - | - | A |
SIGNAL SIGNAL | ||
28 | P | - | - | - | - | P |
SIGNAL SIGNAL | ||
29 | G | - | - | - | - | GALDEIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
30 | L | - | - | - | - | LADEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
31 | L | - | - | - | - | LADEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
32 | W | - | - | - | - | WALDEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
33 | M | - | - | - | - | MALDEGIKPRSTVCFHNQY |
SIGNAL SIGNAL | ||
34 | G | - | - | - | - | GLASDEKTVFINPQRMYCHW |
SIGNAL SIGNAL | ||
35 | L | - | - | - | - | ILCAGSDEFKNPQRTVY |
SIGNAL SIGNAL | ||
36 | V | - | - | - | - | ILVAGSDEFKNPQRTY |
SIGNAL SIGNAL | V->A:(2.0 %):LB/B - dbSNP:rs1050228 | |
37 | L | - | - | - | - | LRAGSDEFIKNPQTVY |
SIGNAL SIGNAL | ||
38 | A | - | - | - | - | GLASDEFIKNPQRTVY |
SIGNAL SIGNAL | ||
39 | L | - | - | - | - | LIAGSDEFKNPQRTVY |
SIGNAL SIGNAL | ||
40 | A | - | - | - | - | GAW |
SIGNAL SIGNAL | ||
41 | L | - | - | - | - | LI |
SIGNAL SIGNAL | ||
42 | A | - | - | - | - | GVA |
SIGNAL SIGNAL | ||
43 | L | - | - | - | - | L |
SIGNAL SIGNAL | ||
44 | A | - | - | - | - | A |
SIGNAL SIGNAL | ||
45 | L | - | - | - | - | L |
SIGNAL SIGNAL | ||
46 | A | - | - | - | - | VA |
SIGNAL SIGNAL | ||
47 | L | - | - | - | - | LS |
|||
48 | A | - | - | - | - | AN |
|||
49 | L | - | - | - | - | LV |
|||
50 | S | - | - | - | - | FPSAGLDEIKNQRTVCHMY |
|||
51 | D | - | - | - | - | DEN |
D->V:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7485899 [MIM:607616] | ||
52 | S | - | - | - | - | S |
|||
53 | R | - | - | - | - | GPRT |
|||
54 | V | - | - | - | - | V |
|||
55 | L | - | - | - | - | L |
|||
56 | W | - | - | - | - | WR |
|||
57 | A | - | - | - | - | KASV |
|||
58 | P | - | - | - | - | P |
|||
59 | A | - | - | - | - | AV |
|||
60 | E | - | - | - | - | EDR |
|||
61 | A | - | - | - | - | AE |
|||
62 | H | - | - | - | - | HRY |
|||
63 | P | - | - | - | - | PE |
|||
64 | L | - | - | - | - | LY |
|||
65 | S | - | - | - | - | PNS |
|||
66 | P | - | - | - | - | APST |
|||
67 | Q | - | - | - | - | QRE |
|||
68 | G | - | - | - | - | G |
|||
69 | H | - | - | - | - | HN |
|||
70 | P | - | - | - | - | PES |
|||
71 | A | - | - | - | - | AV |
|||
72 | R | - | - | - | - | KR |
|||
73 | L | - | - | - | - | FML |
|||
74 | H | - | - | - | - | LHIS |
|||
75 | R | - | - | - | - | RA |
|||
76 | I | - | - | - | - | IY |
|||
77 | V | - | - | - | - | AV |
|||
78 | P | - | - | - | - | PK |
|||
79 | R | - | - | - | - | KPQR |
|||
80 | L | - | - | - | - | LA |
|||
81 | R | - | - | - | - | QIR |
|||
82 | D | - | - | - | - | DNES |
|||
83 | V | - | - | - | - | AKEV |
|||
84 | F | e | 114.4 | 5jg8_B | compound NAG homo | FYP |
|||
85 | G | e | 78.6 | 5jg8_B | compound NAG | GE |
|||
86 | W | G | e | 78.1 | 5jg8_B | compound NAG homo | WFN |
||
87 | G | G | e | 54.8 | 5jg8_B | QRGW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
88 | N | G | e | 73.3 | 5jg8_B | compound NAG otherpoly homo | NPK |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type" | |
89 | L | T | e | 55.6 | 5jg8_B | homo | LM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
90 | T | H | e | 30.5 | 5jg8_B | STAGLDEFIKNPQRVY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
91 | C | H | e | 20.7 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
92 | P | H | e | 56.6 | 5jg8_B | otherpoly homo | DPEIL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
93 | I | H | e | 62.6 | 5jg8_B | homo | IVESFAT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
94 | C | H | b | 10.7 | 5jg8_B | homo | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] |
95 | K | H | e | 41.0 | 5jg8_B | otherpoly homo | KTQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
96 | G | H | e | 48.8 | 5jg8_B | homo | GFISV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
97 | L | H | e | 57.3 | 5jg8_B | compound 6E0 homo | LGIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
98 | F | H | b | 15.3 | 5jg8_B | homo | IVFA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
99 | T | H | e | 43.5 | 5jg8_B | homo | SDTN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
100 | A | H | e | 61.6 | 5jg8_B | compound 6E0 homo | LAQVG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
101 | I | H | e | 41.5 | 5jg8_B | compound 6E0 homo | LVIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
102 | N | H | b | 16.4 | 5jg8_B | QNESD |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
103 | L | H | e | 50.6 | 5jg8_B | FDKAHL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
104 | G | H | e | 34.5 | 5jg8_B | compound 6E0 | FGEML |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
105 | L | H | b | 16.3 | 5jg8_B | compound 6E0 homo | ILW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7512695 [MIM:257200];L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7512695 [MIM:607616] |
106 | K | T | e | 58.5 | 5jg8_B | KAGR |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
107 | K | S | e | 54.7 | 5jg8_B | precipitant | KEFSQN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
108 | E | H | e | 61.3 | 5jg8_B | KNEDQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
109 | P | H | e | 60.5 | 5jg8_B | APKQVS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
110 | N | H | e | 34.5 | 5jg8_B | compound 6E0 homo precipitant | STNG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
111 | V | H | b | 6.0 | 5jg8_B | EVLID |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
112 | A | H | e | 44.6 | 5jg8_B | EATPN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
113 | R | H | e | 58.5 | 5jg8_B | precipitant | ERCDVW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
114 | V | H | e | 44.0 | 5jg8_B | compound 6E0 homo | IV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
115 | G | H | b | 3.6 | 5jg8_B | GILMSA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
116 | S | H | e | 44.5 | 5jg8_B | KESA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
117 | V | H | e | 54.7 | 5jg8_B | homo precipitant | FVGIY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
118 | A | H | e | 36.6 | 5jg8_B | homo | AL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
119 | I | H | b | 10.5 | 5jg8_B | IVST |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
120 | K | H | e | 70.8 | 5jg8_B | precipitant | DKFIN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
121 | L | H | e | 52.8 | 5jg8_B | homo | LIV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
122 | C | H | e | 25.3 | 5jg8_B | homo | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | |
123 | N | H | e | 40.6 | 5jg8_B | KIETDNV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
124 | L | H | e | 69.7 | 5jg8_B | LATYM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
125 | L | H | e | 74.7 | 5jg8_B | FLS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
126 | K | e | 70.3 | 5jg8_B | compound NAG otherpoly | KHADN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
127 | I | e | 89.5 | 5jg8_B | compound NAG homo | IEKV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
128 | A | S | b | 19.6 | 5jg8_B | otherpoly | EAQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
129 | P | e | 34.1 | 5jg8_B | otherpoly | PQDK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
130 | P | H | e | 64.3 | 5jg8_B | PANWL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
131 | A | H | e | 59.8 | 5jg8_B | AEDH |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
132 | V | H | b | 10.0 | 5jg8_B | V |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | V->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
133 | C | H | b | 2.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | ||
134 | Q | H | e | 52.0 | 5jg8_B | precipitant | NQTDK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
135 | S | H | e | 36.7 | 5jg8_B | precipitant | GSFN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
136 | I | H | e | 25.7 | 5jg8_B | homo | IAL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
137 | V | H | b | 13.3 | 5jg8_B | homo | IVLS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
138 | H | H | e | 48.2 | 5jg8_B | otherpoly precipitant | SHNPYQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
139 | L | H | e | 24.2 | 5jg8_B | otherpoly | LNDQA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616] |
140 | F | H | b | 19.6 | 5jg8_B | homo | FY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
141 | E | H | b | 15.1 | 5jg8_B | EVARSK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
142 | D | H | e | 40.7 | 5jg8_B | otherpoly precipitant | DPN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
143 | D | H | b | 18.5 | 5jg8_B | otherpoly | EDIM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
144 | M | H | e | 24.2 | 5jg8_B | homo | FVMIT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
145 | V | H | b | 16.7 | 5jg8_B | homo | VFMY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
146 | E | H | e | 20.1 | 5jg8_B | YEDNF |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
147 | V | H | b | 0.0 | 5jg8_B | V |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
148 | W | H | e | 47.0 | 5jg8_B | homo | LWFI |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
149 | R | H | b | 9.9 | 5jg8_B | RTIKSE |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
150 | R | H | e | 36.0 | 5jg8_B | precipitant | RQY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
151 | S | T | b | 2.3 | 5jg8_B | SAIP |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type" MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type" | ||
152 | V | T | b | 19.3 | 5jg8_B | homo | VDLNT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
153 | L | S | e | 22.5 | 5jg8_B | homo | FVLE |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
154 | S | S | e | 21.9 | 5jg8_B | TS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
155 | P | T | e | 27.1 | 5jg8_B | PG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
156 | S | T | b | 18.0 | 5jg8_B | otherpoly | SEH |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
157 | E | T | b | 8.5 | 5jg8_B | QEY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
158 | A | H | b | 7.1 | 5jg8_B | LIAV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
159 | C | H | b | 0.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7275041 [MIM:607616] | |
160 | G | H | b | 9.5 | 5jg8_B | precipitant | G |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
161 | L | H | e | 56.7 | 5jg8_B | homo precipitant | LYFIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
162 | L | H | e | 64.0 | 5jg8_B | homo precipitant | LFIV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
163 | L | T | e | 46.1 | 5jg8_B | precipitant | LIMADEFGKNPQRSTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7801344 [MIM:607616] |
164 | G | B | b | 17.9 | 5jg8_B | precipitant | GCKPADEFILNQRSTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
165 | S | T | e | 89.8 | 5jg8_B | SNDG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
166 | T | T | e | 92.9 | 5jg8_B | SADFCTEGIKLNPQRV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
167 | C | B | b | 1.3 | 5jg8_B | CTA |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | ||
168 | G | b | 17.9 | 5jg8_B | GDP |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | G->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1847910 [MIM:607616] | ||
169 | H | e | 68.6 | 5jg8_B | HSDPY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |||
170 | W | e | 37.8 | 5jg8_B | SWFTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |||
171 | D | e | 35.8 | 5jg8_B | compound NAG otherpoly | DNPV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
172 | I | T | b | 12.9 | 5jg8_B | LIERS |
|||
173 | F | T | e | 46.4 | 5jg8_B | FYAENT |
|||
174 | S | e | 34.4 | 5jg8_B | precipitant | SRTH |
|||
175 | S | e | 70.3 | 5jg8_B | compound NAG otherpoly precipitant | SQGIMT |
|||
176 | W | b | 9.6 | 5jg8_B | compound NAG | WEADFGIKLNPQRSTV |
|||
177 | N | e | 74.5 | 5jg8_B | compound NAG otherpoly | NSM |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." | ||
178 | I | b | 5.3 | 5jg8_B | otherpoly | ILFMV |
I->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7497807 [MIM:607616] | ||
179 | S | e | 60.2 | 5jg8_B | otherpoly | STGNAI |
|||
180 | L | e | 22.5 | 5jg8_B | LIKN |
||||
181 | P | e | 34.9 | 5jg8_B | precipitant | PGF |
|||
182 | T | S | e | 94.2 | 5jg8_B | GPTLVAS |
|||
183 | V | S | e | 38.0 | 5jg8_B | precipitant | KVTAMGLDEFINPQRSY |
||
184 | P | e | 84.5 | 5jg8_B | precipitant | PKNG |
DISORDER predicted by DISOPRED | ||
185 | K | e | 35.8 | 5jg8_B | precipitant | KANQ |
DISORDER predicted by DISOPRED | ||
186 | P | e | 34.1 | 5jg8_B | PGQR |
DISORDER predicted by DISOPRED | P->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1057517 [MIM:257200] | ||
187 | P | e | 86.0 | 5jg8_B | PGKQT |
DISORDER predicted by DISOPRED | |||
188 | P | e | 60.5 | 5jg8_B | PLRVFSYHI |
DISORDER predicted by DISOPRED | |||
189 | K | e | 59.4 | 5jg8_B | precipitant | KVNQ |
DISORDER predicted by DISOPRED | ||
190 | P | e | 64.3 | 5jg8_B | PIDK |
DISORDER predicted by DISOPRED | |||
191 | P | e | 44.2 | 5jg8_B | PKLTVW |
DISORDER predicted by DISOPRED | |||
192 | S | e | 65.6 | 5jg8_B | precipitant | SVKLDPQA |
DISORDER predicted by DISOPRED | ||
193 | P | e | 90.7 | 5jg8_B | PAGIKNQV |
DISORDER predicted by DISOPRED | |||
194 | P | e | 39.5 | 5jg8_B | PGKQVIA |
DISORDER predicted by DISOPRED | |||
195 | A | e | 58.0 | 5jg8_B | ASPGDEK |
DISORDER predicted by DISOPRED | |||
196 | P | T | e | 104.7 | 5jg8_B | PKDETIY |
DISORDER predicted by DISOPRED | ||
197 | G | T | e | 106.0 | 5jg8_B | GNEQR |
|||
198 | A | e | 25.0 | 5jg8_B | AKSVDMNP |
A->P:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616] | |||
199 | P | e | 51.2 | 5jg8_B | PSLQA |
||||
200 | V | E | e | 48.7 | 5jg8_B | precipitant | VTIHLM |
||
201 | S | E | b | 1.6 | 5jg8_B | precipitant | GSKLFM |
||
202 | R | E | b | 19.0 | 5jg8_B | precipitant | RQKY |
R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7495952 [MIM:607616] | |
203 | I | E | b | 1.2 | 5jg8_B | FVIA |
|||
204 | L | E | b | 0.0 | 5jg8_B | precipitant | LW |
||
205 | F | E | b | 0.5 | 5jg8_B | HQF |
|||
206 | L | E | b | 1.1 | 5jg8_B | ILV |
|||
207 | T | b | 1.9 | 5jg8_B | TSA |
||||
208 | D | b | 0.0 | 5jg8_B | compound PC C5P NT8 AP2 metal ZN precipitant | D |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | ||
209 | L | b | 3.9 | 5jg8_B | LIMTVF |
||||
210 | H | b | 0.0 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | ||
211 | W | B | b | 6.8 | 5jg8_B | metal CL otherpoly | PLVWFIY |
W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |
212 | D | b | 3.1 | 5jg8_B | D |
||||
213 | H | S | e | 42.4 | 5jg8_B | compound NAG metal CL otherpoly precipitant | PHFIMQKLE |
||
214 | D | e | 25.9 | 5jg8_B | otherpoly | YDTFELMQVN |
|||
215 | Y | B | b | 5.7 | 5jg8_B | metal CL | Y |
||
216 | L | e | 24.7 | 5jg8_B | metal CL | KVETLIHADGPS |
L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1590738 [MIM:257200] | ||
217 | E | T | e | 39.7 | 5jg8_B | metal CL | EVHKPYSTAI |
||
218 | G | T | e | 41.7 | 5jg8_B | GISHPNT |
|||
219 | T | S | b | 3.9 | 5jg8_B | STGKLAM |
|||
220 | D | b | 8.6 | 5jg8_B | homo | DESNAFGIKLPQRTV |
|||
221 | P | S | b | 4.7 | 5jg8_B | APITEVLDGKSCFHMNQRY |
|||
222 | D | S | e | 46.9 | 5jg8_B | DNYAGLFEIKPQRSTV |
|||
223 | C | b | 13.3 | 5jg8_B | CSQEHTGKDR |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |||
224 | A | S | e | 63.4 | 5jg8_B | compound NAG otherpoly | AGTVIDQEFKLNPRS |
||
225 | D | S | e | 24.7 | 5jg8_B | DKCTERYHNALFGIPQSV |
MUTAGEN /note="D->A: Does not affect cleavage by CASP7." MUTAGEN /note="D->A: Does not affect cleavage by CASP7." | ||
226 | P | S | e | 34.9 | 5jg8_B | otherpoly homo | PAVHTNEGKLSCDFIMQRY |
||
227 | L | S | b | 0.0 | 5jg8_B | LVCYQKMAGDEINPRSTFH |
L->M:(6.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616];L->P:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7643179 [MIM:607616] | ||
228 | C | b | 0.0 | 5jg8_B | CALTVDEFGIKNPQRSY |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1564923 [MIM:257200] | ||
229 | C | S | b | 0.0 | 5jg8_B | precipitant | CSYLADEFGIKNPQRTV |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |
230 | R | B | b | 2.4 | 5jg8_B | precipitant | RHSDALEFGIKNPQTVY |
R->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs9896392 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs9896392 [MIM:607616];R->H:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1413877 [MIM:257200] | |
231 | R | T | e | 65.2 | 5jg8_B | compound C5P precipitant | RDKSEGHPVALFINQTY |
||
232 | G | T | e | 92.9 | 5jg8_B | compound NAG otherpoly precipitant | GSHDNQPVY |
||
233 | S | S | b | 10.9 | 5jg8_B | precipitant | SKAVTDNP |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." | |
234 | G | e | 54.8 | 5jg8_B | compound NAG otherpoly precipitant | GNDAMSY |
G->D:(7.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
235 | L | e | 78.7 | 5jg8_B | precipitant | EKSDANRLVPWGIQTCFHMY |
|||
236 | P | e | 20.2 | 5jg8_B | homo | PQTVDSAEGLFHIKMNRY |
|||
237 | P | e | 63.6 | 5jg8_B | homo precipitant | PEKSTAGLVCDFHIMNQRY |
|||
238 | A | T | e | 98.2 | 5jg8_B | homo precipitant | AVNKLISYGDEFPQRT |
||
239 | S | T | e | 90.6 | 5jg8_B | homo precipitant | SGDLEVKAFINPQRTY |
||
240 | R | e | 32.4 | 5jg8_B | homo | KENRQGDALFIPSTVY |
|||
241 | P | e | 76.7 | 5jg8_B | PDKSGNYAEFILQRTV |
||||
242 | G | e | 33.3 | 5jg8_B | GAKRTSVDN |
||||
243 | A | b | 8.0 | 5jg8_B | homo | APNGVD |
A->V:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1291958 [MIM:257200] | ||
244 | G | b | 13.1 | 5jg8_B | GAVPSDEIKLNRT |
G->R:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | |||
245 | Y | T | e | 50.0 | 5jg8_B | YPKRLESVFADGINT |
|||
246 | W | T | b | 16.3 | 5jg8_B | precipitant | WFYILG |
W->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
247 | G | b | 0.0 | 5jg8_B | GA |
G->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs5877794 [MIM:257200];G->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5877794 [MIM:607616];G->D:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1590739 [MIM:257200] | |||
248 | E | b | 18.6 | 5jg8_B | DEHNSRPMKT |
E->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2007634 [MIM:607616];E->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2007634 [MIM:257200] | |||
249 | Y | S | b | 13.0 | 5jg8_B | homo precipitant | YVMGALPDEKST |
||
250 | S | S | e | 29.7 | 5jg8_B | precipitant | SGYVMLADEIKPRTCFHNQ |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." | S->R:(2.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7507798 [MIM:257200];S->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7507798 [MIM:607616] |
251 | K | S | e | 25.5 | 5jg8_B | precipitant | LKGDSEMAIPRTV |
||
252 | C | b | 0.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |||
253 | D | b | 0.0 | 5jg8_B | D |
MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" | D->E:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7520007 [MIM:257200];D->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3981234 [MIM:257200] | ||
254 | L | B | b | 0.0 | 5jg8_B | SLTIGAC |
SITE /note="Cleavage; by CASP7" SITE /note="Cleavage; by CASP7" | ||
255 | P | b | 4.7 | 5jg8_B | PNIS |
P->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
256 | L | H | e | 35.4 | 5jg8_B | compound NAG otherpoly | YFMLQWDIV |
||
257 | R | H | e | 20.2 | 5jg8_B | metal CL | AQSRLWKEDIVY |
||
258 | T | H | b | 0.0 | 5jg8_B | LTM |
T->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
259 | L | H | b | 1.7 | 5jg8_B | LIMVF |
|||
260 | E | H | e | 54.8 | 5jg8_B | otherpoly | ENLDSQTF |
||
261 | S | H | b | 14.8 | 5jg8_B | precipitant | SENAWLDIYM |
||
262 | L | H | b | 2.2 | 5jg8_B | TAMLSIV |
|||
263 | L | H | b | 5.6 | 5jg8_B | LFIKMH |
|||
264 | S | H | e | 63.3 | 5jg8_B | otherpoly homo | DSKEQYAR |
||
265 | G | T | e | 34.5 | 5jg8_B | WHFNGAEY |
|||
266 | L | T | b | 7.3 | 5jg8_B | precipitant | ILMVQ |
||
267 | G | S | e | 66.7 | 5jg8_B | homo precipitant | KADGLNSV |
||
268 | P | S | e | 78.3 | 5jg8_B | homo | ENKTPQADS |
||
269 | A | S | e | 32.1 | 5jg8_B | ASTKVNIHGR |
|||
270 | G | b | 10.7 | 5jg8_B | homo | DGENHK |
|||
271 | P | e | 82.2 | 5jg8_B | homo precipitant | EKPDQSGM |
|||
272 | F | b | 12.4 | 5jg8_B | precipitant | ILAFKNVE |
|||
273 | D | S | e | 45.1 | 5jg8_B | precipitant | DSE |
||
274 | M | E | b | 4.8 | 5jg8_B | FMYI |
|||
275 | V | E | b | 0.0 | 5jg8_B | IVM |
|||
276 | Y | E | b | 0.0 | 5jg8_B | IVLYMF |
|||
277 | W | E | b | 0.8 | 5jg8_B | WYIMV |
|||
278 | T | b | 0.6 | 5jg8_B | TS |
||||
279 | G | b | 2.4 | 5jg8_B | G |
||||
280 | D | b | 0.6 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | D |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | D->A:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1847935 [MIM:257200] | |
281 | I | b | 1.2 | 5jg8_B | NDSIGFLTY |
||||
282 | P | B | b | 3.1 | 5jg8_B | PAVITES |
P->F:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
283 | A | b | 3.6 | 5jg8_B | otherpoly | RPAGNS |
A->T:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7521485 [MIM:607616] | ||
284 | H | S | b | 11.0 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | H |
||
285 | D | b | 9.3 | 5jg8_B | otherpoly | DVNGLT |
|||
286 | V | b | 17.3 | 5jg8_B | homo precipitant | VINPSRLDGT |
|||
287 | W | S | b | 9.6 | 5jg8_B | WDYNVKLPR |
|||
288 | H | S | e | 40.8 | 5jg8_B | otherpoly | EPHSRADNQL |
||
289 | Q | b | 3.1 | 5jg8_B | otherpoly | QRYELGHKMPS |
|||
290 | T | e | 39.0 | 5jg8_B | otherpoly precipitant | STLFVINR |
|||
291 | R | H | e | 27.3 | 5jg8_B | otherpoly precipitant | PEQTRGSINAY |
R->H:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1803161 [MIM:607616] | |
292 | Q | H | e | 78.6 | 5jg8_B | precipitant | EQRDGTASL |
||
293 | D | H | e | 24.1 | 5jg8_B | metal CL precipitant | TDAENQSLG |
||
294 | Q | H | b | 4.6 | 5jg8_B | QIAVHTPKGL |
Q->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | ||
295 | L | H | e | 27.5 | 5jg8_B | LFISVDEKRAG |
|||
296 | R | H | e | 33.2 | 5jg8_B | metal CL otherpoly | ERFQLDNSYGIKA |
R->Q:(10.0 %):LB/B - dbSNP:rs3582445 | |
297 | A | H | b | 5.4 | 5jg8_B | metal CL | AVMINESDYGL |
||
298 | L | H | b | 1.7 | 5jg8_B | LINVMFTSAG |
|||
299 | T | H | e | 45.5 | 5jg8_B | TAQNRGKDFEVL |
|||
300 | T | H | e | 32.5 | 5jg8_B | compound NAG otherpoly | NTSQERKLIAG |
||
301 | V | H | b | 0.7 | 5jg8_B | LVMNIQAG |
|||
302 | T | H | b | 2.6 | 5jg8_B | TSRAEHQV |
|||
303 | A | H | e | 52.7 | 5jg8_B | compound NAG otherpoly | NDTEARMQWKSV |
||
304 | L | H | b | 14.0 | 5jg8_B | compound NAG | LTIVKDM |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | |
305 | V | H | b | 0.0 | 5jg8_B | VIAFGMT |
|||
306 | R | H | e | 50.6 | 5jg8_B | otherpoly | KQDRLNEHY |
||
307 | K | H | e | 70.3 | 5jg8_B | homo precipitant | KESNRGLT |
||
308 | F | H | e | 32.5 | 5jg8_B | homo | LMTYFV |
||
309 | L | H | b | 9.6 | 5jg8_B | precipitant | FLYAIQSR |
||
310 | G | T | e | 36.9 | 5jg8_B | homo | PGEKADRT |
||
311 | P | T | e | 103.1 | 5jg8_B | homo | DNKPSAEGV |
||
312 | V | S | e | 22.0 | 5jg8_B | homo | VTILYM |
||
313 | P | e | 31.8 | 5jg8_B | homo | PKQS |
|||
314 | V | E | b | 0.0 | 5jg8_B | VIFL |
V->M:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1228068 [MIM:607616] | ||
315 | Y | E | b | 6.5 | 5jg8_B | YVFIL |
Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
316 | P | E | b | 0.8 | 5jg8_B | PAFSVW |
|||
317 | A | b | 1.8 | 5jg8_B | AST |
||||
318 | V | b | 0.7 | 5jg8_B | LIV |
V->E:(0.0 %):LB/B - dbSNP:rs1257513 | |||
319 | G | b | 0.0 | 5jg8_B | G |
G->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7579347 [MIM:257200] | |||
320 | N | S | b | 1.2 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | N |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | N->D:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7799276 [MIM:607616] |
321 | H | S | b | 9.9 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | HN |
H->Y:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2134012 [MIM:257200] | |
322 | E | S | b | 2.5 | 5jg8_B | DE |
|||
323 | S | S | b | 1.6 | 5jg8_B | precipitant | VSGIYFA |
||
324 | T | S | b | 7.8 | 5jg8_B | otherpoly | FYVWLTHAG |
T->I:(0.0 %):LB/B - dbSNP:rs1050233;T->P:(0.0 %):US Niemann-Pick disease A (NPDA) [MIM:257200] | |
325 | P | S | b | 1.6 | 5jg8_B | PAGL |
P->A:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7613082 [MIM:607616] | ||
326 | V | T | b | 10.7 | 5jg8_B | precipitant | HVQKAGL |
||
327 | N | T | b | 7.3 | 5jg8_B | homo | NDHAGL |
||
328 | S | b | 2.3 | 5jg8_B | QLSMAGINDEFKPRTVY |
||||
329 | F | b | 0.0 | 5jg8_B | FLIYMADEGKPSTV |
||||
330 | P | b | 2.3 | 5jg8_B | PASGLVDEFIKNQRT |
||||
331 | P | b | 0.8 | 5jg8_B | PVGADILEFKNQRST |
||||
332 | P | T | e | 38.8 | 5jg8_B | PHYSLAEGVDFIKNQRTCMW |
P->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2020819 [MIM:607616] | ||
333 | F | T | e | 41.6 | 5jg8_B | otherpoly precipitant | TFNISALEGKVDPQRCHMWY |
||
334 | I | S | b | 2.9 | 5jg8_B | precipitant | LVMISTAEGKDFNPQRCHWY |
||
335 | E | e | 77.4 | 5jg8_B | precipitant | QEKLPDYAGSTVFINRCHMW |
|||
336 | G | S | e | 46.4 | 5jg8_B | GAECDKLSVIPRTFNQYHMW |
|||
337 | N | S | e | 75.8 | 5jg8_B | otherpoly | NGAKPRSTLDEIVFQYCHMW |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." | |
338 | H | S | e | 31.9 | 5jg8_B | otherpoly precipitant | QDLGPFNRYAHEKSTVICMW |
||
339 | S | S | b | 7.0 | 5jg8_B | SGVHNPWAQDEFIKLRT |
|||
340 | S | S | b | 3.1 | 5jg8_B | precipitant | STPNMR |
||
341 | R | H | e | 48.6 | 5jg8_B | precipitant | RQSNTDHAEGIKLPV |
||
342 | W | H | b | 12.7 | 5jg8_B | precipitant | WEKFLNRADGIPQSTV |
||
343 | L | H | b | 1.1 | 5jg8_B | LIVMY |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
344 | Y | H | b | 2.2 | 5jg8_B | YTFLAEGKSV |
|||
345 | E | H | e | 45.7 | 5jg8_B | precipitant | ENKRDSQAFGILPTV |
||
346 | A | H | b | 17.0 | 5jg8_B | AQEITHSNDFGKLPRV |
|||
347 | M | T | b | 0.0 | 5jg8_B | MVLFIYAGSDEKNPQRT |
|||
348 | A | T | b | 3.6 | 5jg8_B | ASLQTYGDEFIKNPRV |
|||
349 | K | T | e | 78.8 | 5jg8_B | ENRTKQDGHLYAIPSV |
|||
350 | A | S | b | 19.6 | 5jg8_B | LIAMDYEGKPRSTV |
|||
351 | W | S | b | 0.8 | 5jg8_B | WS |
|||
352 | E | T | e | 55.8 | 5jg8_B | otherpoly homo | KSAREGDQH |
||
353 | P | T | e | 41.1 | 5jg8_B | homo | PDQHAGREKN |
||
354 | W | T | b | 10.8 | 5jg8_B | homo | WFL |
||
355 | L | S | b | 3.4 | 5jg8_B | otherpoly homo | LIV |
||
356 | P | e | 48.8 | 5jg8_B | otherpoly homo | PSDNGT |
|||
357 | A | H | e | 61.6 | 5jg8_B | otherpoly homo | EANQTYPSV |
||
358 | E | H | e | 62.8 | 5jg8_B | otherpoly precipitant | EDANGQ |
||
359 | A | H | b | 0.0 | 5jg8_B | QASE |
A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970448 [MIM:607616] | ||
360 | L | H | b | 7.3 | 5jg8_B | otherpoly | LIQRVEKAY |
||
361 | R | H | e | 58.5 | 5jg8_B | HSRADEKNQT |
|||
362 | T | H | b | 14.3 | 5jg8_B | precipitant | TSLIANVM |
||
363 | L | H | b | 0.0 | 5jg8_B | FLV |
L->R:(0.0 %):US Niemann-Pick disease A (NPDA) dbSNP:rs2134013 [MIM:257200] | ||
364 | R | H | e | 41.5 | 5jg8_B | precipitant | KERQLDNS |
||
365 | I | H | e | 51.5 | 5jg8_B | precipitant | RKYIEFLH |
||
366 | G | T | b | 1.2 | 5jg8_B | GRDNSY |
|||
367 | G | S | b | 0.0 | 5jg8_B | GAST |
|||
368 | F | b | 6.2 | 5jg8_B | precipitant | SYFCW |
|||
369 | Y | E | b | 0.4 | 5jg8_B | YF |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3722878 [MIM:257200] | ||
370 | A | E | b | 7.1 | 5jg8_B | SFTALVMYC |
|||
371 | L | E | b | 5.1 | 5jg8_B | VTELKCSQ |
|||
372 | S | e | 50.8 | 5jg8_B | homo | ESKLADQTYP |
|||
373 | P | S | b | 16.3 | 5jg8_B | compound NAG otherpoly precipitant | VPISANT |
P->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1342372 [MIM:607616] | |
374 | Y | S | b | 7.4 | 5jg8_B | compound NAG otherpoly precipitant | ISNKYVMRQ |
||
375 | P | T | e | 79.1 | 5jg8_B | compound NAG | PSDEGRT |
||
376 | G | T | e | 44.0 | 5jg8_B | GDNAK |
|||
377 | L | E | b | 0.6 | 5jg8_B | LGF |
|||
378 | R | E | b | 13.0 | 5jg8_B | precipitant | RAKT |
R->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5590880 [MIM:607616];R->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
379 | L | E | b | 0.0 | 5jg8_B | VILAM |
|||
380 | I | E | b | 0.0 | 5jg8_B | ILVFM |
|||
381 | S | E | b | 0.8 | 5jg8_B | SVT |
S->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
382 | L | b | 0.0 | 5jg8_B | LIF |
||||
383 | N | b | 0.0 | 5jg8_B | N |
||||
384 | M | G | b | 0.0 | 5jg8_B | TMN |
M->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];M->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | ||
385 | N | G | b | 0.0 | 5jg8_B | LNIVG |
N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | ||
386 | F | G | b | 0.0 | 5jg8_B | YLFEW |
|||
387 | C | G | b | 0.0 | 5jg8_B | YCLFGNMW |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |
388 | S | b | 1.6 | 5jg8_B | compound C5P AP2 precipitant | YFSDEN |
|||
389 | R | S | e | 47.4 | 5jg8_B | KNRVGDEMQST |
|||
390 | E | S | e | 59.3 | 5jg8_B | compound NT8 homo precipitant | SAEKPIGFRTN |
||
391 | N | b | 0.6 | 5jg8_B | N |
N->T:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];N->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2134017 [MIM:257200] | |||
392 | F | G | b | 11.5 | 5jg8_B | homo | FAIPKLRTGSDENQVY |
||
393 | W | G | b | 0.0 | 5jg8_B | YWANGLEFQMPSKTVCDHIR |
W->G:(7.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];W->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
394 | L | G | b | 0.6 | 5jg8_B | LVTPMCNQS |
|||
395 | L | G | b | 17.4 | 5jg8_B | LTYCVFDAR |
|||
396 | I | T | b | 18.1 | 5jg8_B | DLVAISE |
|||
397 | N | e | 45.5 | 5jg8_B | compound NAG otherpoly precipitant | NDTPSEGH |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." | ||
398 | S | b | 7.0 | 5jg8_B | compound NAG precipitant | NKSQPMELTC |
|||
399 | T | S | e | 37.0 | 5jg8_B | compound NAG otherpoly precipitant | TCSKNAQLV |
||
400 | D | S | b | 9.9 | 5jg8_B | compound NAG otherpoly | DEGNS |
||
401 | P | G | b | 3.9 | 5jg8_B | otherpoly | PSEKN |
||
402 | A | G | e | 31.2 | 5jg8_B | otherpoly precipitant | AGDKCNPR |
||
403 | G | G | e | 41.7 | 5jg8_B | otherpoly precipitant | GKNASEHQ |
||
404 | Q | H | b | 0.0 | 5jg8_B | QSTEHKLM |
|||
405 | L | H | b | 0.0 | 5jg8_B | LFMS |
|||
406 | Q | H | e | 36.7 | 5jg8_B | otherpoly precipitant | EQLDRASV |
||
407 | W | H | e | 23.5 | 5jg8_B | otherpoly precipitant | W |
||
408 | L | H | b | 0.0 | 5jg8_B | LFMIV |
|||
409 | V | H | b | 0.7 | 5jg8_B | otherpoly precipitant | GEVIKNR |
||
410 | G | H | e | 52.4 | 5jg8_B | compound NAG otherpoly | NEDIYVQSGKF |
||
411 | E | H | b | 18.1 | 5jg8_B | otherpoly | TQVE |
||
412 | L | H | b | 0.6 | 5jg8_B | L |
|||
413 | Q | H | b | 7.1 | 5jg8_B | compound NAG otherpoly | QENDIAFHKST |
||
414 | A | H | e | 27.7 | 5jg8_B | compound FUC otherpoly | EANDISQ |
||
415 | A | H | b | 0.9 | 5jg8_B | ASMLYFI |
A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1451199 [MIM:607616] | ||
416 | E | H | b | 18.1 | 5jg8_B | precipitant | RESQKL |
||
417 | D | H | e | 72.2 | 5jg8_B | compound NAG otherpoly precipitant | QDNLEKSARW |
||
418 | R | H | e | 50.6 | 5jg8_B | compound FUC otherpoly | RNAKVDI |
||
419 | G | T | e | 73.8 | 5jg8_B | GKN |
|||
420 | D | b | 5.6 | 5jg8_B | EMDN |
||||
421 | K | E | e | 25.9 | 5jg8_B | KQMSLR |
|||
422 | V | E | b | 0.7 | 5jg8_B | VA |
|||
423 | H | E | b | 0.5 | 5jg8_B | WYHIL |
H->Y:(35.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];H->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7674920 [MIM:257200] | ||
424 | I | E | b | 0.6 | 5jg8_B | ILV |
|||
425 | I | E | b | 1.2 | 5jg8_B | ISVLMT |
|||
426 | G | E | b | 0.0 | 5jg8_B | GAS |
G->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200] | ||
427 | H | S | b | 0.0 | 5jg8_B | compound PC NT8 RP5 C5P AP2 metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | H->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7947276 [MIM:607616] |
428 | I | S | b | 2.9 | 5jg8_B | VI |
|||
429 | P | b | 0.0 | 5jg8_B | PF |
||||
430 | P | T | b | 0.0 | 5jg8_B | PVDK |
|||
431 | G | T | e | 20.2 | 5jg8_B | GANSDK |
|||
432 | H | S | e | 44.5 | 5jg8_B | precipitant | YEHSFQRADKN |
||
433 | C | S | b | 0.0 | 5jg8_B | compound RP5 PC precipitant | CFLNIMASTWY |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7795285 [MIM:607616] |
434 | L | b | 12.9 | 5jg8_B | LYERQKTADIP |
L->P:(3.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |||
435 | K | S | e | 44.3 | 5jg8_B | compound NAG precipitant | KDEGSQNR |
||
436 | S | H | b | 10.2 | 5jg8_B | compound NAG precipitant | SGYTLKND |
||
437 | W | H | b | 1.2 | 5jg8_B | precipitant | WYCFDALHQS |
W->C:(13.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
438 | S | H | b | 0.0 | 5jg8_B | compound NAG | SNAYDCVK |
S->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2676070 [MIM:607616] | |
439 | W | H | e | 35.1 | 5jg8_B | precipitant | WEFLSATDQIY |
||
440 | N | H | b | 3.6 | 5jg8_B | precipitant | NKQSMRDEWTAGL |
||
441 | Y | H | b | 0.0 | 5jg8_B | YLFKTCAGS |
|||
442 | Y | H | b | 0.0 | 5jg8_B | YFLTEGHAIVS |
|||
443 | R | H | e | 25.3 | 5jg8_B | otherpoly precipitant | DKRNSQELAGIPTV |
||
444 | I | H | b | 0.6 | 5jg8_B | precipitant | ILVKSWADEGNPQRT |
||
445 | V | H | b | 2.0 | 5jg8_B | VFLIMTA |
|||
446 | A | H | b | 3.6 | 5jg8_B | RQSHNTAYGKLE |
|||
447 | R | H | b | 9.5 | 5jg8_B | precipitant | REQKD |
||
448 | Y | T | b | 0.9 | 5jg8_B | precipitant | YFH |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7471433 [MIM:257200] | |
449 | E | T | b | 7.5 | 5jg8_B | metal ZN | RSEQHA |
||
450 | N | T | e | 30.9 | 5jg8_B | metal ZN | DNSRT |
||
451 | T | T | b | 6.5 | 5jg8_B | TVI |
|||
452 | L | E | b | 6.7 | 5jg8_B | IVL |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
453 | A | E | b | 12.5 | 5jg8_B | AIVTEL |
A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
454 | A | E | b | 3.6 | 5jg8_B | GAFQS |
A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1402734 [MIM:607616] | ||
455 | Q | E | b | 0.0 | 5jg8_B | QGHSM |
|||
456 | F | E | b | 0.0 | 5jg8_B | FLVI |
|||
457 | F | E | b | 0.0 | 5jg8_B | YF |
|||
458 | G | E | b | 0.0 | 5jg8_B | G |
G->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
459 | H | E | b | 18.8 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | |
460 | T | E | b | 15.6 | 5jg8_B | compound C5P NT8 PC YA4 precipitant | MTHIDE |
||
461 | H | E | b | 8.9 | 5jg8_B | compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant | HN |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | |
462 | V | S | b | 13.3 | 5jg8_B | compound C5P AP2 AMP precipitant | IRVTYMLS |
||
463 | D | b | 5.6 | 5jg8_B | DEN |
||||
464 | E | E | b | 6.5 | 5jg8_B | HESQKTY |
|||
465 | F | E | b | 2.9 | 5jg8_B | FIL |
F->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1319643 [MIM:257200] | ||
466 | E | E | b | 2.5 | 5jg8_B | MSREVTYALDFGIKNPQ |
|||
467 | V | E | b | 0.0 | 5jg8_B | VMFIL |
|||
468 | F | E | b | 0.0 | 5jg8_B | FLYQIM |
|||
469 | Y | E | b | 3.5 | 5jg8_B | YSFHLI |
Y->S:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200] | ||
470 | D | b | 5.6 | 5jg8_B | DEA |
||||
471 | E | T | e | 40.2 | 5jg8_B | DEKVNF |
|||
472 | E | T | e | 75.4 | 5jg8_B | DNPAEKGILQRSTV |
|||
473 | T | T | e | 52.6 | 5jg8_B | TNSKEVPYDGALFIQR |
|||
474 | L | S | b | 18.5 | 5jg8_B | LKSDHNPTVAGEFIQRY |
|||
475 | S | e | 60.9 | 5jg8_B | SGTERHALDFIKNPQVY |
||||
476 | R | S | e | 37.2 | 5jg8_B | metal CL | RNKSITEADFGLPQV |
R->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1828129 [MIM:607616];R->Q:(1.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7635669 [MIM:607616] | |
477 | P | E | b | 13.2 | 5jg8_B | PDNAEGKLSTV |
P->L:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7535088 [MIM:257200];P->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7535088 [MIM:607616] | ||
478 | L | E | b | 9.0 | 5jg8_B | ITLHVFMAEGKS |
|||
479 | A | E | b | 6.2 | 5jg8_B | NSGYAHEKLTV |
|||
480 | V | E | b | 6.7 | 5jg8_B | VFSIMAEGKLT |
|||
481 | A | E | b | 0.0 | 5jg8_B | MGVNALIEKST |
|||
482 | F | E | b | 2.9 | 5jg8_B | FYQWAEGKLSTV |
F->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
483 | L | E | b | 0.0 | 5jg8_B | LIVASTEGK |
|||
484 | A | E | b | 0.0 | 5jg8_B | ASTGVEKL |
A->E:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200] | ||
485 | P | E | b | 1.6 | 5jg8_B | PGS |
|||
486 | S | b | 0.0 | 5jg8_B | SAGLV |
||||
487 | A | S | b | 0.0 | 5jg8_B | VALDI |
A->V:(43.0 %):LB/B - dbSNP:rs1416412 | ||
488 | T | S | b | 0.0 | 5jg8_B | compound PC precipitant | TD |
T->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
489 | T | b | 0.0 | 5jg8_B | TPEN |
||||
490 | Y | T | e | 22.2 | 5jg8_B | compound C5P precipitant | YVSFLWR |
Y->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3981234 [MIM:607616] | |
491 | I | T | e | 56.7 | 5jg8_B | compound C5P NT8 precipitant | IYQKPSDEML |
||
492 | G | T | e | 20.2 | 5jg8_B | precipitant | GDNFWYHST |
G->S:(4.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1448733 [MIM:607616] | |
493 | L | b | 4.5 | 5jg8_B | precipitant | VIQLNHY |
|||
494 | N | b | 2.4 | 5jg8_B | NKEF |
N->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
495 | P | b | 0.0 | 5jg8_B | P |
||||
496 | G | E | b | 0.0 | 5jg8_B | GAKTS |
G->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | ||
497 | Y | E | b | 1.7 | 5jg8_B | YFIVL |
|||
498 | R | E | b | 0.4 | 5jg8_B | RVK |
R->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7699047 [MIM:607616];R->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | ||
499 | V | E | b | 0.0 | 5jg8_B | precipitant | ILVKQ |
||
500 | Y | E | b | 0.0 | 5jg8_B | YFS |
|||
501 | Q | E | b | 12.2 | 5jg8_B | precipitant | QETL |
||
502 | I | E | b | 0.6 | 5jg8_B | IFVLAEGSDKNPQRTCHMWY |
|||
503 | D | E | b | 1.9 | 5jg8_B | DLAEGSVFIKNPQRTCHMWY |
|||
504 | G | b | 1.2 | 5jg8_B | GASLEVDIKNPRTFQYCHMW |
||||
505 | N | S | e | 45.5 | 5jg8_B | compound NAG otherpoly precipitant | NQGVLAESDIKPRTFYCHMW |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." | |
506 | Y | S | e | 30.0 | 5jg8_B | precipitant | YHAGLDEFIKNPQRSTV |
||
507 | S | T | e | 89.1 | 5jg8_B | DKAPSENFGILQRTV |
S->G:(1.0 %):LB/B - | ||
508 | G | T | e | 94.0 | 5jg8_B | precipitant | GPYRSILADEFKNQTV |
G->R:(11.0 %):LB/B - dbSNP:rs1050239 | |
509 | S | b | 4.7 | 5jg8_B | SAQGRNTLDEFIKPVY |
||||
510 | S | b | 6.2 | 5jg8_B | TSDKAEGILNPRV |
MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" | S->F:(0.0 %):LB/B - dbSNP:rs2006526 | ||
511 | H | b | 2.6 | 5jg8_B | YFHKLNGADEIPRSTV |
||||
512 | V | b | 14.7 | 5jg8_B | KNQTVAYSDEGILPR |
||||
513 | V | E | b | 4.0 | 5jg8_B | LVIADEGKNPRST |
|||
514 | L | E | b | 19.1 | 5jg8_B | LKVTIMADEGNPRS |
|||
515 | D | E | b | 15.4 | 5jg8_B | precipitant | DEN |
||
516 | H | E | b | 1.0 | 5jg8_B | YMLHIAFS |
H->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1590747 [MIM:607616] | ||
517 | E | E | b | 3.0 | 5jg8_B | precipitant | ETVYLPKS |
E->V:(14.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1427870 [MIM:607616] | |
518 | T | E | b | 0.0 | 5jg8_B | TQAE |
|||
519 | Y | E | b | 6.5 | 5jg8_B | precipitant | YFW |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3718372 [MIM:257200] | |
520 | I | E | b | 1.2 | 5jg8_B | compound NAG otherpoly | FYHIPW |
I->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
521 | L | E | b | 0.0 | 5jg8_B | LATESMF |
|||
522 | N | e | 23.0 | 5jg8_B | compound NAG otherpoly | ND |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." | N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
523 | L | H | b | 0.0 | 5jg8_B | LVI |
|||
524 | T | H | e | 57.1 | 5jg8_B | compound NAG otherpoly precipitant | TSYER |
||
525 | Q | H | e | 62.2 | 5jg8_B | compound NAG otherpoly precipitant | EQDIKS |
Q->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
526 | A | H | b | 2.7 | 5jg8_B | ANES |
|||
527 | N | T | e | 24.2 | 5jg8_B | homo | NFIT |
||
528 | I | S | e | 56.7 | 5jg8_B | compound NAG homo | LAEIMVGS |
||
529 | P | T | e | 96.1 | 5jg8_B | otherpoly homo precipitant | KNQTEPSA |
||
530 | G | T | e | 96.4 | 5jg8_B | homo | GPDN |
||
531 | A | e | 33.9 | 5jg8_B | homo precipitant | TEKAHNG |
|||
532 | I | e | 83.0 | 5jg8_B | TVIMLKNEAGSCDFHPQRY |
||||
533 | P | e | 20.2 | 5jg8_B | precipitant | PSGVDLAEFIKNQRTY |
|||
534 | H | e | 67.0 | 5jg8_B | compound NAG otherpoly homo | NRKVEHTISAL |
|||
535 | W | E | b | 7.2 | 5jg8_B | WYF |
W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200];W->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | ||
536 | Q | E | e | 30.6 | 5jg8_B | compound NAG metal ZN otherpoly | EQTKSVLY |
||
537 | L | e | 31.5 | 5jg8_B | precipitant | LEKVQR |
|||
538 | L | e | 25.3 | 5jg8_B | otherpoly | ELTS |
|||
539 | Y | b | 4.8 | 5jg8_B | precipitant | Y |
Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
540 | R | B | e | 36.4 | 5jg8_B | precipitant | RDSQNITV |
||
541 | A | H | b | 0.0 | 5jg8_B | ALTF |
|||
542 | R | H | e | 41.1 | 5jg8_B | precipitant | TRVKN |
||
543 | E | H | e | 78.9 | 5jg8_B | precipitant | EQSMN |
||
544 | T | H | e | 31.8 | 5jg8_B | precipitant | ATIEFLH |
||
545 | Y | H | b | 3.5 | 5jg8_B | YFH |
|||
546 | G | T | e | 65.5 | 5jg8_B | GNDQS |
|||
547 | L | b | 2.8 | 5jg8_B | IMLVT |
||||
548 | P | S | e | 69.0 | 5jg8_B | PDAFKQE |
|||
549 | N | e | 32.1 | 5jg8_B | DNG |
N->K:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |||
550 | T | S | b | 1.9 | 5jg8_B | LAQFT |
|||
551 | L | S | e | 26.4 | 5jg8_B | SQYILTM |
L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
552 | P | H | b | 19.4 | 5jg8_B | PGAV |
|||
553 | T | H | e | 48.7 | 5jg8_B | TIKLVQHSAE |
|||
554 | A | H | b | 6.2 | 5jg8_B | precipitant | SGAE |
||
555 | W | H | b | 1.2 | 5jg8_B | WLMY |
|||
556 | H | H | b | 17.8 | 5jg8_B | precipitant | HNYTDS |
||
557 | N | H | e | 50.9 | 5jg8_B | KDTSGNEQLA |
|||
558 | L | H | b | 0.0 | 5jg8_B | LVAM |
|||
559 | V | H | b | 0.7 | 5jg8_B | IAVLMYS |
|||
560 | Y | H | e | 23.9 | 5jg8_B | precipitant | QEDYKLNT |
||
561 | R | H | e | 37.9 | 5jg8_B | RQKLN |
|||
562 | M | H | b | 1.4 | 5jg8_B | MILF |
|||
563 | R | H | e | 30.0 | 5jg8_B | precipitant | AKRVTFQNW |
||
564 | G | H | e | 76.2 | 5jg8_B | precipitant | TSGKQDI |
||
565 | D | e | 42.0 | 5jg8_B | precipitant | DSNEV |
D->Y:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
566 | M | H | e | 30.9 | 5jg8_B | precipitant | STNEDPQM |
||
567 | Q | H | e | 77.0 | 5jg8_B | precipitant | SKTQH |
||
568 | L | H | b | 14.6 | 5jg8_B | LQIMKT |
|||
569 | F | H | b | 0.0 | 5jg8_B | FLR |
|||
570 | Q | H | e | 37.2 | 5jg8_B | precipitant | NQLEIR |
||
571 | T | H | e | 33.1 | 5jg8_B | precipitant | KDTRNS |
||
572 | F | H | b | 1.9 | 5jg8_B | YF |
F->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
573 | W | H | b | 13.1 | 5jg8_B | YHWVAGLSDEFIKNPQRT |
|||
574 | F | H | e | 45.5 | 5jg8_B | compound NAG otherpoly precipitant | FYEHQRVKN |
||
575 | L | H | b | 3.9 | 5jg8_B | YLVNEHAGST |
|||
576 | Y | H | b | 17.8 | 5jg8_B | precipitant | YFAHN |
||
577 | H | T | b | 11.5 | 5jg8_B | compound NT8 | NFYHL |
H->D:(0.0 %):US Niemann-Pick disease B (NPDB) [MIM:607616] | |
578 | K | T | b | 0.0 | 5jg8_B | SRVK |
K->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7473424 [MIM:607616] | ||
579 | G | T | e | 20.2 | 5jg8_B | compound NAG otherpoly precipitant | SVNGRA |
G->S:(29.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | |
580 | H | e | 34.0 | 5jg8_B | compound NAG homo precipitant | YSHF |
|||
581 | P | e | 36.4 | 5jg8_B | homo precipitant | PDYS |
|||
582 | P | e | 51.9 | 5jg8_B | compound NAG otherpoly homo precipitant | PSNGIE |
|||
583 | S | S | e | 102.3 | 5jg8_B | homo precipitant | SKQRTNAH |
||
584 | E | S | e | 79.4 | 5jg8_B | precipitant | EAKVLGST |
||
585 | P | e | 84.5 | 5jg8_B | precipitant | PTGSVILADEFKNQRY |
|||
586 | C | b | 18.7 | 5jg8_B | precipitant | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
587 | G | e | 21.4 | 5jg8_B | precipitant | DGNTYEQ |
|||
588 | T | H | e | 55.2 | 5jg8_B | precipitant | QTSEDGK |
||
589 | P | H | e | 79.8 | 5jg8_B | metal ZN precipitant | ASKPTIQHR |
||
590 | C | H | e | 21.3 | 5jg8_B | precipitant | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |
591 | R | H | b | 8.7 | 5jg8_B | precipitant | RKQS |
||
592 | L | H | e | 27.5 | 5jg8_B | precipitant | LTMIKNYA |
||
593 | A | H | e | 58.0 | 5jg8_B | QAFGIKLDTE |
|||
594 | T | H | b | 8.4 | 5jg8_B | QYTHLWF |
|||
595 | L | H | b | 0.0 | 5jg8_B | precipitant | ILVM |
||
596 | C | H | e | 26.7 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
597 | A | H | e | 36.6 | 5jg8_B | ADNSK |
|||
598 | Q | H | b | 1.0 | 5jg8_B | precipitant | IMQLN |
Q->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | |
599 | L | H | b | 0.0 | 5jg8_B | LKMRQ |
L->F:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1385319 [MIM:607616] | ||
600 | S | b | 19.5 | 5jg8_B | SNMKHQD |
||||
601 | A | b | 0.9 | 5jg8_B | AGLVS |
||||
602 | R | S | b | 7.9 | 5jg8_B | precipitant | RDAHM |
R->H:(13.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3701290 [MIM:257200];R->H:(13.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3701290 [MIM:607616];R->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
603 | A | T | b | 5.4 | 5jg8_B | SAHYFIVNL |
|||
604 | D | T | e | 49.4 | 5jg8_B | precipitant | DNYILV |
||
605 | S | b | 8.6 | 5jg8_B | metal ZN precipitant | SDKAT |
S->G:(0.0 %):LB/B - | ||
606 | P | G | e | 83.7 | 5jg8_B | precipitant | YPTED |
||
607 | A | G | e | 48.2 | 5jg8_B | precipitant | ATLSYCE |
||
608 | L | G | b | 5.1 | 5jg8_B | LDTYFE |
|||
609 | C | G | b | 12.7 | 5jg8_B | CK |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
610 | R | G | e | 54.5 | 5jg8_B | RDILQAEGKNPSTV |
R->C:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs3759151 [MIM:607616] | ||
611 | H | G | e | 49.7 | 5jg8_B | precipitant | HADEGIKLNPRSTV |
||
612 | L | G | b | 1.1 | 5jg8_B | L |
|||
613 | M | e | 84.5 | 5jg8_B | MYV |
||||
614 | P | e | 131.0 | 5fic_C | PA |
||||
615 | D | - | - | - | - | DSN |
|||
616 | G | - | - | - | - | GA |
|||
617 | S | - | - | - | - | ST |
|||
618 | L | - | - | - | - | LT |
|||
619 | P | - | - | - | - | P |
|||
620 | E | - | - | - | - | DVE |
|||
621 | A | - | - | - | - | APV |
|||
622 | Q | - | - | - | - | QN |
|||
623 | S | - | - | - | - | SR |
|||
624 | L | - | - | - | - | L |
|||
625 | W | - | - | - | - | W |
|||
626 | P | - | - | - | - | SP |
|||
627 | R | - | - | - | - | RM |
|||
628 | P | - | - | - | - | P |
|||
629 | L | - | - | - | - | L |
|||
630 | F | - | - | - | - | LF |
|||
631 | C | - | - | - | - | C |