Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2692367 631 35 P17405(ASM_HUMAN) RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor;
QUERYSEQ 
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR
SVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT
VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYEN
TLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
ARADSPALCRHLMPDGSLPEAQSLWPRPLFC
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ] 
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
1M---- 
M
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
2P---- 
P
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
3R---- 
RH
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
4Y---- 
HY
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
5G---- 
GR
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
6A---- 
AV
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
7S---- 
S
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
8L---- 
SLP
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
9R---- 
GR
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
10Q---- 
Q
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
11S---- 
DGS
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
12C---- 
HCL
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
13P---- 
PL
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
14R---- 
R
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
15S---- 
SA
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
16G---- 
G
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
17R---- 
RW
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
18E---- 
E
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
19Q---- 
Q
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
20G---- 
RAG
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
21Q---- 
LQS
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
22D---- 
DE
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
23G---- 
RG
 REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL
24T---- 
ST
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
25A---- 
LA
 SIGNAL DISORDER predicted by DISOPRED SIGNAL
26G---- 
GP
 SIGNAL SIGNAL
27A---- 
A
 SIGNAL SIGNAL
28P---- 
P
 SIGNAL SIGNAL
29G---- 
GALDEIKPRSTVCFHMNQY
 SIGNAL SIGNAL
30L---- 
LADEGIKPRSTVCFHMNQY
 SIGNAL SIGNAL
31L---- 
LADEGIKPRSTVCFHMNQY
 SIGNAL SIGNAL
32W---- 
WALDEGIKPRSTVCFHMNQY
 SIGNAL SIGNAL
33M---- 
MALDEGIKPRSTVCFHNQY
 SIGNAL SIGNAL
34G---- 
GLASDEKTVFINPQRMYCHW
 SIGNAL SIGNAL
35L---- 
ILCAGSDEFKNPQRTVY
 SIGNAL SIGNAL
36V---- 
ILVAGSDEFKNPQRTY
 SIGNAL SIGNAL V->A:(2.0 %):LB/B - dbSNP:rs1050228
37L---- 
LRAGSDEFIKNPQTVY
 SIGNAL SIGNAL
38A---- 
GLASDEFIKNPQRTVY
 SIGNAL SIGNAL
39L---- 
LIAGSDEFKNPQRTVY
 SIGNAL SIGNAL
40A---- 
GAW
 SIGNAL SIGNAL
41L---- 
LI
 SIGNAL SIGNAL
42A---- 
GVA
 SIGNAL SIGNAL
43L---- 
L
 SIGNAL SIGNAL
44A---- 
A
 SIGNAL SIGNAL
45L---- 
L
 SIGNAL SIGNAL
46A---- 
VA
 SIGNAL SIGNAL
47L---- 
LS
48A---- 
AN
49L---- 
LV
50S---- 
FPSAGLDEIKNQRTVCHMY
51D---- 
DEN
 D->V:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7485899 [MIM:607616]
52S---- 
S
53R---- 
GPRT
54V---- 
V
55L---- 
L
56W---- 
WR
57A---- 
KASV
58P---- 
P
59A---- 
AV
60E---- 
EDR
61A---- 
AE
62H---- 
HRY
63P---- 
PE
64L---- 
LY
65S---- 
PNS
66P---- 
APST
67Q---- 
QRE
68G---- 
G
69H---- 
HN
70P---- 
PES
71A---- 
AV
72R---- 
KR
73L---- 
FML
74H---- 
LHIS
75R---- 
RA
76I---- 
IY
77V---- 
AV
78P---- 
PK
79R---- 
KPQR
80L---- 
LA
81R---- 
QIR
82D---- 
DNES
83V---- 
AKEV
84F e114.4 5jg8_B compound NAG homo 
FYP
85G e 78.6 5jg8_B compound NAG 
GE
86WGe 78.1 5jg8_B compound NAG homo 
WFN
87GGe 54.8 5jg8_B 
QRGW
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
88NGe 73.3 5jg8_B compound NAG otherpoly homo 
NPK
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type"
89LTe 55.6 5jg8_B homo 
LM
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
90THe 30.5 5jg8_B 
STAGLDEFIKNPQRVY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
91CHe 20.7 5jg8_B 
C
 DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" C->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
92PHe 56.6 5jg8_B otherpoly homo 
DPEIL
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
93IHe 62.6 5jg8_B homo 
IVESFAT
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
94CHb 10.7 5jg8_B homo 
C
 DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" C->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
95KHe 41.0 5jg8_B otherpoly homo 
KTQ
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
96GHe 48.8 5jg8_B homo 
GFISV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
97LHe 57.3 5jg8_B compound 6E0 homo 
LGIA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
98FHb 15.3 5jg8_B homo 
IVFA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
99THe 43.5 5jg8_B homo 
SDTN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
100AHe 61.6 5jg8_B compound 6E0 homo 
LAQVG
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
101IHe 41.5 5jg8_B compound 6E0 homo 
LVIA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
102NHb 16.4 5jg8_B 
QNESD
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
103LHe 50.6 5jg8_B 
FDKAHL
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
104GHe 34.5 5jg8_B compound 6E0 
FGEML
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
105LHb 16.3 5jg8_B compound 6E0 homo 
ILW
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7512695 [MIM:257200];L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7512695 [MIM:607616]
106KTe 58.5 5jg8_B 
KAGR
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
107KSe 54.7 5jg8_B precipitant 
KEFSQN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
108EHe 61.3 5jg8_B 
KNEDQ
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
109PHe 60.5 5jg8_B 
APKQVS
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
110NHe 34.5 5jg8_B compound 6E0 homo precipitant 
STNG
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
111VHb 6.0 5jg8_B 
EVLID
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
112AHe 44.6 5jg8_B 
EATPN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
113RHe 58.5 5jg8_B precipitant 
ERCDVW
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
114VHe 44.0 5jg8_B compound 6E0 homo 
IV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
115GHb 3.6 5jg8_B 
GILMSA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
116SHe 44.5 5jg8_B 
KESA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
117VHe 54.7 5jg8_B homo precipitant 
FVGIY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
118AHe 36.6 5jg8_B homo 
AL
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
119IHb 10.5 5jg8_B 
IVST
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
120KHe 70.8 5jg8_B precipitant 
DKFIN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
121LHe 52.8 5jg8_B homo 
LIV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
122CHe 25.3 5jg8_B homo 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type"
123NHe 40.6 5jg8_B 
KIETDNV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
124LHe 69.7 5jg8_B 
LATYM
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
125LHe 74.7 5jg8_B 
FLS
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
126K e 70.3 5jg8_B compound NAG otherpoly 
KHADN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
127I e 89.5 5jg8_B compound NAG homo 
IEKV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
128ASb 19.6 5jg8_B otherpoly 
EAQ
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
129P e 34.1 5jg8_B otherpoly 
PQDK
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
130PHe 64.3 5jg8_B 
PANWL
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
131AHe 59.8 5jg8_B 
AEDH
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
132VHb 10.0 5jg8_B 
V
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" V->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
133CHb 2.0 5jg8_B 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type"
134QHe 52.0 5jg8_B precipitant 
NQTDK
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
135SHe 36.7 5jg8_B precipitant 
GSFN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
136IHe 25.7 5jg8_B homo 
IAL
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
137VHb 13.3 5jg8_B homo 
IVLS
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
138HHe 48.2 5jg8_B otherpoly precipitant 
SHNPYQ
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
139LHe 24.2 5jg8_B otherpoly 
LNDQA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616]
140FHb 19.6 5jg8_B homo 
FY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
141EHb 15.1 5jg8_B 
EVARSK
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
142DHe 40.7 5jg8_B otherpoly precipitant 
DPN
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
143DHb 18.5 5jg8_B otherpoly 
EDIM
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
144MHe 24.2 5jg8_B homo 
FVMIT
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
145VHb 16.7 5jg8_B homo 
VFMY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
146EHe 20.1 5jg8_B 
YEDNF
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
147VHb 0.0 5jg8_B 
V
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
148WHe 47.0 5jg8_B homo 
LWFI
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
149RHb 9.9 5jg8_B 
RTIKSE
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
150RHe 36.0 5jg8_B precipitant 
RQY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
151STb 2.3 5jg8_B 
SAIP
 MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type" MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type"
152VTb 19.3 5jg8_B homo 
VDLNT
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
153LSe 22.5 5jg8_B homo 
FVLE
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
154SSe 21.9 5jg8_B 
TS
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
155PTe 27.1 5jg8_B 
PG
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
156STb 18.0 5jg8_B otherpoly 
SEH
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
157ETb 8.5 5jg8_B 
QEY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
158AHb 7.1 5jg8_B 
LIAV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
159CHb 0.0 5jg8_B 
C
 DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7275041 [MIM:607616]
160GHb 9.5 5jg8_B precipitant 
G
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
161LHe 56.7 5jg8_B homo precipitant 
LYFIA
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
162LHe 64.0 5jg8_B homo precipitant 
LFIV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
163LTe 46.1 5jg8_B precipitant 
LIMADEFGKNPQRSTV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" L->P:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7801344 [MIM:607616]
164GBb 17.9 5jg8_B precipitant 
GCKPADEFILNQRSTV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
165STe 89.8 5jg8_B 
SNDG
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
166TTe 92.9 5jg8_B 
SADFCTEGIKLNPQRV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
167CBb 1.3 5jg8_B 
CTA
 DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type"
168G b 17.9 5jg8_B 
GDP
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" G->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1847910 [MIM:607616]
169H e 68.6 5jg8_B 
HSDPY
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
170W e 37.8 5jg8_B 
SWFTV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
171D e 35.8 5jg8_B compound NAG otherpoly 
DNPV
 DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type"
172ITb 12.9 5jg8_B 
LIERS
173FTe 46.4 5jg8_B 
FYAENT
174S e 34.4 5jg8_B precipitant 
SRTH
175S e 70.3 5jg8_B compound NAG otherpoly precipitant 
SQGIMT
176W b 9.6 5jg8_B compound NAG 
WEADFGIKLNPQRSTV
177N e 74.5 5jg8_B compound NAG otherpoly 
NSM
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion."
178I b 5.3 5jg8_B otherpoly 
ILFMV
 I->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7497807 [MIM:607616]
179S e 60.2 5jg8_B otherpoly 
STGNAI
180L e 22.5 5jg8_B 
LIKN
181P e 34.9 5jg8_B precipitant 
PGF
182TSe 94.2 5jg8_B 
GPTLVAS
183VSe 38.0 5jg8_B precipitant 
KVTAMGLDEFINPQRSY
184P e 84.5 5jg8_B precipitant 
PKNG
 DISORDER predicted by DISOPRED
185K e 35.8 5jg8_B precipitant 
KANQ
 DISORDER predicted by DISOPRED
186P e 34.1 5jg8_B 
PGQR
 DISORDER predicted by DISOPRED P->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1057517 [MIM:257200]
187P e 86.0 5jg8_B 
PGKQT
 DISORDER predicted by DISOPRED
188P e 60.5 5jg8_B 
PLRVFSYHI
 DISORDER predicted by DISOPRED
189K e 59.4 5jg8_B precipitant 
KVNQ
 DISORDER predicted by DISOPRED
190P e 64.3 5jg8_B 
PIDK
 DISORDER predicted by DISOPRED
191P e 44.2 5jg8_B 
PKLTVW
 DISORDER predicted by DISOPRED
192S e 65.6 5jg8_B precipitant 
SVKLDPQA
 DISORDER predicted by DISOPRED
193P e 90.7 5jg8_B 
PAGIKNQV
 DISORDER predicted by DISOPRED
194P e 39.5 5jg8_B 
PGKQVIA
 DISORDER predicted by DISOPRED
195A e 58.0 5jg8_B 
ASPGDEK
 DISORDER predicted by DISOPRED
196PTe104.7 5jg8_B 
PKDETIY
 DISORDER predicted by DISOPRED
197GTe106.0 5jg8_B 
GNEQR
198A e 25.0 5jg8_B 
AKSVDMNP
 A->P:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616]
199P e 51.2 5jg8_B 
PSLQA
200VEe 48.7 5jg8_B precipitant 
VTIHLM
201SEb 1.6 5jg8_B precipitant 
GSKLFM
202REb 19.0 5jg8_B precipitant 
RQKY
 R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7495952 [MIM:607616]
203IEb 1.2 5jg8_B 
FVIA
204LEb 0.0 5jg8_B precipitant 
LW
205FEb 0.5 5jg8_B 
HQF
206LEb 1.1 5jg8_B 
ILV
207T b 1.9 5jg8_B 
TSA
208D b 0.0 5jg8_B compound PC C5P NT8 AP2 metal ZN precipitant 
D
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
209L b 3.9 5jg8_B 
LIMTVF
210H b 0.0 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
H
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
211WBb 6.8 5jg8_B metal CL otherpoly 
PLVWFIY
 W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
212D b 3.1 5jg8_B 
D
213HSe 42.4 5jg8_B compound NAG metal CL otherpoly precipitant 
PHFIMQKLE
214D e 25.9 5jg8_B otherpoly 
YDTFELMQVN
215YBb 5.7 5jg8_B metal CL 
Y
216L e 24.7 5jg8_B metal CL 
KVETLIHADGPS
 L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
217ETe 39.7 5jg8_B metal CL 
EVHKPYSTAI
218GTe 41.7 5jg8_B 
GISHPNT
219TSb 3.9 5jg8_B 
STGKLAM
220D b 8.6 5jg8_B homo 
DESNAFGIKLPQRTV
221PSb 4.7 5jg8_B 
APITEVLDGKSCFHMNQRY
222DSe 46.9 5jg8_B 
DNYAGLFEIKPQRSTV
223C b 13.3 5jg8_B 
CSQEHTGKDR
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
224ASe 63.4 5jg8_B compound NAG otherpoly 
AGTVIDQEFKLNPRS
225DSe 24.7 5jg8_B 
DKCTERYHNALFGIPQSV
 MUTAGEN /note="D->A: Does not affect cleavage by CASP7." MUTAGEN /note="D->A: Does not affect cleavage by CASP7."
226PSe 34.9 5jg8_B otherpoly homo 
PAVHTNEGKLSCDFIMQRY
227LSb 0.0 5jg8_B 
LVCYQKMAGDEINPRSTFH
 L->M:(6.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616];L->P:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7643179 [MIM:607616]
228C b 0.0 5jg8_B 
CALTVDEFGIKNPQRSY
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1564923 [MIM:257200]
229CSb 0.0 5jg8_B precipitant 
CSYLADEFGIKNPQRTV
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
230RBb 2.4 5jg8_B precipitant 
RHSDALEFGIKNPQTVY
 R->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs9896392 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs9896392 [MIM:607616];R->H:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1413877 [MIM:257200]
231RTe 65.2 5jg8_B compound C5P precipitant 
RDKSEGHPVALFINQTY
232GTe 92.9 5jg8_B compound NAG otherpoly precipitant 
GSHDNQPVY
233SSb 10.9 5jg8_B precipitant 
SKAVTDNP
 MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD."
234G e 54.8 5jg8_B compound NAG otherpoly precipitant 
GNDAMSY
 G->D:(7.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
235L e 78.7 5jg8_B precipitant 
EKSDANRLVPWGIQTCFHMY
236P e 20.2 5jg8_B homo 
PQTVDSAEGLFHIKMNRY
237P e 63.6 5jg8_B homo precipitant 
PEKSTAGLVCDFHIMNQRY
238ATe 98.2 5jg8_B homo precipitant 
AVNKLISYGDEFPQRT
239STe 90.6 5jg8_B homo precipitant 
SGDLEVKAFINPQRTY
240R e 32.4 5jg8_B homo 
KENRQGDALFIPSTVY
241P e 76.7 5jg8_B 
PDKSGNYAEFILQRTV
242G e 33.3 5jg8_B 
GAKRTSVDN
243A b 8.0 5jg8_B homo 
APNGVD
 A->V:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1291958 [MIM:257200]
244G b 13.1 5jg8_B 
GAVPSDEIKLNRT
 G->R:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616]
245YTe 50.0 5jg8_B 
YPKRLESVFADGINT
246WTb 16.3 5jg8_B precipitant 
WFYILG
 W->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
247G b 0.0 5jg8_B 
GA
 G->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs5877794 [MIM:257200];G->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5877794 [MIM:607616];G->D:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1590739 [MIM:257200]
248E b 18.6 5jg8_B 
DEHNSRPMKT
 E->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2007634 [MIM:607616];E->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2007634 [MIM:257200]
249YSb 13.0 5jg8_B homo precipitant 
YVMGALPDEKST
250SSe 29.7 5jg8_B precipitant 
SGYVMLADEIKPRTCFHNQ
 MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." S->R:(2.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7507798 [MIM:257200];S->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7507798 [MIM:607616]
251KSe 25.5 5jg8_B precipitant 
LKGDSEMAIPRTV
252C b 0.0 5jg8_B 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
253D b 0.0 5jg8_B 
D
 MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" D->E:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];D->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3981234 [MIM:257200]
254LBb 0.0 5jg8_B 
SLTIGAC
 SITE /note="Cleavage; by CASP7" SITE /note="Cleavage; by CASP7"
255P b 4.7 5jg8_B 
PNIS
 P->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
256LHe 35.4 5jg8_B compound NAG otherpoly 
YFMLQWDIV
257RHe 20.2 5jg8_B metal CL 
AQSRLWKEDIVY
258THb 0.0 5jg8_B 
LTM
 T->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
259LHb 1.7 5jg8_B 
LIMVF
260EHe 54.8 5jg8_B otherpoly 
ENLDSQTF
261SHb 14.8 5jg8_B precipitant 
SENAWLDIYM
262LHb 2.2 5jg8_B 
TAMLSIV
263LHb 5.6 5jg8_B 
LFIKMH
264SHe 63.3 5jg8_B otherpoly homo 
DSKEQYAR
265GTe 34.5 5jg8_B 
WHFNGAEY
266LTb 7.3 5jg8_B precipitant 
ILMVQ
267GSe 66.7 5jg8_B homo precipitant 
KADGLNSV
268PSe 78.3 5jg8_B homo 
ENKTPQADS
269ASe 32.1 5jg8_B 
ASTKVNIHGR
270G b 10.7 5jg8_B homo 
DGENHK
271P e 82.2 5jg8_B homo precipitant 
EKPDQSGM
272F b 12.4 5jg8_B precipitant 
ILAFKNVE
273DSe 45.1 5jg8_B precipitant 
DSE
274MEb 4.8 5jg8_B 
FMYI
275VEb 0.0 5jg8_B 
IVM
276YEb 0.0 5jg8_B 
IVLYMF
277WEb 0.8 5jg8_B 
WYIMV
278T b 0.6 5jg8_B 
TS
279G b 2.4 5jg8_B 
G
280D b 0.6 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
D
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" D->A:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
281I b 1.2 5jg8_B 
NDSIGFLTY
282PBb 3.1 5jg8_B 
PAVITES
 P->F:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
283A b 3.6 5jg8_B otherpoly 
RPAGNS
 A->T:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7521485 [MIM:607616]
284HSb 11.0 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
H
285D b 9.3 5jg8_B otherpoly 
DVNGLT
286V b 17.3 5jg8_B homo precipitant 
VINPSRLDGT
287WSb 9.6 5jg8_B 
WDYNVKLPR
288HSe 40.8 5jg8_B otherpoly 
EPHSRADNQL
289Q b 3.1 5jg8_B otherpoly 
QRYELGHKMPS
290T e 39.0 5jg8_B otherpoly precipitant 
STLFVINR
291RHe 27.3 5jg8_B otherpoly precipitant 
PEQTRGSINAY
 R->H:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1803161 [MIM:607616]
292QHe 78.6 5jg8_B precipitant 
EQRDGTASL
293DHe 24.1 5jg8_B metal CL precipitant 
TDAENQSLG
294QHb 4.6 5jg8_B 
QIAVHTPKGL
 Q->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200]
295LHe 27.5 5jg8_B 
LFISVDEKRAG
296RHe 33.2 5jg8_B metal CL otherpoly 
ERFQLDNSYGIKA
 R->Q:(10.0 %):LB/B - dbSNP:rs3582445
297AHb 5.4 5jg8_B metal CL 
AVMINESDYGL
298LHb 1.7 5jg8_B 
LINVMFTSAG
299THe 45.5 5jg8_B 
TAQNRGKDFEVL
300THe 32.5 5jg8_B compound NAG otherpoly 
NTSQERKLIAG
301VHb 0.7 5jg8_B 
LVMNIQAG
302THb 2.6 5jg8_B 
TSRAEHQV
303AHe 52.7 5jg8_B compound NAG otherpoly 
NDTEARMQWKSV
304LHb 14.0 5jg8_B compound NAG 
LTIVKDM
 L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200]
305VHb 0.0 5jg8_B 
VIAFGMT
306RHe 50.6 5jg8_B otherpoly 
KQDRLNEHY
307KHe 70.3 5jg8_B homo precipitant 
KESNRGLT
308FHe 32.5 5jg8_B homo 
LMTYFV
309LHb 9.6 5jg8_B precipitant 
FLYAIQSR
310GTe 36.9 5jg8_B homo 
PGEKADRT
311PTe103.1 5jg8_B homo 
DNKPSAEGV
312VSe 22.0 5jg8_B homo 
VTILYM
313P e 31.8 5jg8_B homo 
PKQS
314VEb 0.0 5jg8_B 
VIFL
 V->M:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1228068 [MIM:607616]
315YEb 6.5 5jg8_B 
YVFIL
 Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
316PEb 0.8 5jg8_B 
PAFSVW
317A b 1.8 5jg8_B 
AST
318V b 0.7 5jg8_B 
LIV
 V->E:(0.0 %):LB/B - dbSNP:rs1257513
319G b 0.0 5jg8_B 
G
 G->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7579347 [MIM:257200]
320NSb 1.2 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
N
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" N->D:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7799276 [MIM:607616]
321HSb 9.9 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
HN
 H->Y:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
322ESb 2.5 5jg8_B 
DE
323SSb 1.6 5jg8_B precipitant 
VSGIYFA
324TSb 7.8 5jg8_B otherpoly 
FYVWLTHAG
 T->I:(0.0 %):LB/B - dbSNP:rs1050233;T->P:(0.0 %):US Niemann-Pick disease A (NPDA) [MIM:257200]
325PSb 1.6 5jg8_B 
PAGL
 P->A:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7613082 [MIM:607616]
326VTb 10.7 5jg8_B precipitant 
HVQKAGL
327NTb 7.3 5jg8_B homo 
NDHAGL
328S b 2.3 5jg8_B 
QLSMAGINDEFKPRTVY
329F b 0.0 5jg8_B 
FLIYMADEGKPSTV
330P b 2.3 5jg8_B 
PASGLVDEFIKNQRT
331P b 0.8 5jg8_B 
PVGADILEFKNQRST
332PTe 38.8 5jg8_B 
PHYSLAEGVDFIKNQRTCMW
 P->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2020819 [MIM:607616]
333FTe 41.6 5jg8_B otherpoly precipitant 
TFNISALEGKVDPQRCHMWY
334ISb 2.9 5jg8_B precipitant 
LVMISTAEGKDFNPQRCHWY
335E e 77.4 5jg8_B precipitant 
QEKLPDYAGSTVFINRCHMW
336GSe 46.4 5jg8_B 
GAECDKLSVIPRTFNQYHMW
337NSe 75.8 5jg8_B otherpoly 
NGAKPRSTLDEIVFQYCHMW
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion."
338HSe 31.9 5jg8_B otherpoly precipitant 
QDLGPFNRYAHEKSTVICMW
339SSb 7.0 5jg8_B 
SGVHNPWAQDEFIKLRT
340SSb 3.1 5jg8_B precipitant 
STPNMR
341RHe 48.6 5jg8_B precipitant 
RQSNTDHAEGIKLPV
342WHb 12.7 5jg8_B precipitant 
WEKFLNRADGIPQSTV
343LHb 1.1 5jg8_B 
LIVMY
 L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
344YHb 2.2 5jg8_B 
YTFLAEGKSV
345EHe 45.7 5jg8_B precipitant 
ENKRDSQAFGILPTV
346AHb 17.0 5jg8_B 
AQEITHSNDFGKLPRV
347MTb 0.0 5jg8_B 
MVLFIYAGSDEKNPQRT
348ATb 3.6 5jg8_B 
ASLQTYGDEFIKNPRV
349KTe 78.8 5jg8_B 
ENRTKQDGHLYAIPSV
350ASb 19.6 5jg8_B 
LIAMDYEGKPRSTV
351WSb 0.8 5jg8_B 
WS
352ETe 55.8 5jg8_B otherpoly homo 
KSAREGDQH
353PTe 41.1 5jg8_B homo 
PDQHAGREKN
354WTb 10.8 5jg8_B homo 
WFL
355LSb 3.4 5jg8_B otherpoly homo 
LIV
356P e 48.8 5jg8_B otherpoly homo 
PSDNGT
357AHe 61.6 5jg8_B otherpoly homo 
EANQTYPSV
358EHe 62.8 5jg8_B otherpoly precipitant 
EDANGQ
359AHb 0.0 5jg8_B 
QASE
 A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970448 [MIM:607616]
360LHb 7.3 5jg8_B otherpoly 
LIQRVEKAY
361RHe 58.5 5jg8_B 
HSRADEKNQT
362THb 14.3 5jg8_B precipitant 
TSLIANVM
363LHb 0.0 5jg8_B 
FLV
 L->R:(0.0 %):US Niemann-Pick disease A (NPDA) [MIM:257200]
364RHe 41.5 5jg8_B precipitant 
KERQLDNS
365IHe 51.5 5jg8_B precipitant 
RKYIEFLH
366GTb 1.2 5jg8_B 
GRDNSY
367GSb 0.0 5jg8_B 
GAST
368F b 6.2 5jg8_B precipitant 
SYFCW
369YEb 0.4 5jg8_B 
YF
 Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3722878 [MIM:257200]
370AEb 7.1 5jg8_B 
SFTALVMYC
371LEb 5.1 5jg8_B 
VTELKCSQ
372S e 50.8 5jg8_B homo 
ESKLADQTYP
373PSb 16.3 5jg8_B compound NAG otherpoly precipitant 
VPISANT
 P->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1342372 [MIM:607616]
374YSb 7.4 5jg8_B compound NAG otherpoly precipitant 
ISNKYVMRQ
375PTe 79.1 5jg8_B compound NAG 
PSDEGRT
376GTe 44.0 5jg8_B 
GDNAK
377LEb 0.6 5jg8_B 
LGF
378REb 13.0 5jg8_B precipitant 
RAKT
 R->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5590880 [MIM:607616];R->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
379LEb 0.0 5jg8_B 
VILAM
380IEb 0.0 5jg8_B 
ILVFM
381SEb 0.8 5jg8_B 
SVT
 S->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
382L b 0.0 5jg8_B 
LIF
383N b 0.0 5jg8_B 
N
384MGb 0.0 5jg8_B 
TMN
 M->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];M->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616]
385NGb 0.0 5jg8_B 
LNIVG
 N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616]
386FGb 0.0 5jg8_B 
YLFEW
387CGb 0.0 5jg8_B 
YCLFGNMW
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
388S b 1.6 5jg8_B compound C5P AP2 precipitant 
YFSDEN
389RSe 47.4 5jg8_B 
KNRVGDEMQST
390ESe 59.3 5jg8_B compound NT8 homo precipitant 
SAEKPIGFRTN
391N b 0.6 5jg8_B 
N
 N->T:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];N->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
392FGb 11.5 5jg8_B homo 
FAIPKLRTGSDENQVY
393WGb 0.0 5jg8_B 
YWANGLEFQMPSKTVCDHIR
 W->G:(7.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];W->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
394LGb 0.6 5jg8_B 
LVTPMCNQS
395LGb 17.4 5jg8_B 
LTYCVFDAR
396ITb 18.1 5jg8_B 
DLVAISE
397N e 45.5 5jg8_B compound NAG otherpoly precipitant 
NDTPSEGH
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion."
398S b 7.0 5jg8_B compound NAG precipitant 
NKSQPMELTC
399TSe 37.0 5jg8_B compound NAG otherpoly precipitant 
TCSKNAQLV
400DSb 9.9 5jg8_B compound NAG otherpoly 
DEGNS
401PGb 3.9 5jg8_B otherpoly 
PSEKN
402AGe 31.2 5jg8_B otherpoly precipitant 
AGDKCNPR
403GGe 41.7 5jg8_B otherpoly precipitant 
GKNASEHQ
404QHb 0.0 5jg8_B 
QSTEHKLM
405LHb 0.0 5jg8_B 
LFMS
406QHe 36.7 5jg8_B otherpoly precipitant 
EQLDRASV
407WHe 23.5 5jg8_B otherpoly precipitant 
W
408LHb 0.0 5jg8_B 
LFMIV
409VHb 0.7 5jg8_B otherpoly precipitant 
GEVIKNR
410GHe 52.4 5jg8_B compound NAG otherpoly 
NEDIYVQSGKF
411EHb 18.1 5jg8_B otherpoly 
TQVE
412LHb 0.6 5jg8_B 
L
413QHb 7.1 5jg8_B compound NAG otherpoly 
QENDIAFHKST
414AHe 27.7 5jg8_B compound FUC otherpoly 
EANDISQ
415AHb 0.9 5jg8_B 
ASMLYFI
 A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1451199 [MIM:607616]
416EHb 18.1 5jg8_B precipitant 
RESQKL
417DHe 72.2 5jg8_B compound NAG otherpoly precipitant 
QDNLEKSARW
418RHe 50.6 5jg8_B compound FUC otherpoly 
RNAKVDI
419GTe 73.8 5jg8_B 
GKN
420D b 5.6 5jg8_B 
EMDN
421KEe 25.9 5jg8_B 
KQMSLR
422VEb 0.7 5jg8_B 
VA
423HEb 0.5 5jg8_B 
WYHIL
 H->Y:(35.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];H->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7674920 [MIM:257200]
424IEb 0.6 5jg8_B 
ILV
425IEb 1.2 5jg8_B 
ISVLMT
426GEb 0.0 5jg8_B 
GAS
 G->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200]
427HSb 0.0 5jg8_B compound PC NT8 RP5 C5P AP2 metal ZN precipitant 
H
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" H->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7947276 [MIM:607616]
428ISb 2.9 5jg8_B 
VI
429P b 0.0 5jg8_B 
PF
430PTb 0.0 5jg8_B 
PVDK
431GTe 20.2 5jg8_B 
GANSDK
432HSe 44.5 5jg8_B precipitant 
YEHSFQRADKN
433CSb 0.0 5jg8_B compound RP5 PC precipitant 
CFLNIMASTWY
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7795285 [MIM:607616]
434L b 12.9 5jg8_B 
LYERQKTADIP
 L->P:(3.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
435KSe 44.3 5jg8_B compound NAG precipitant 
KDEGSQNR
436SHb 10.2 5jg8_B compound NAG precipitant 
SGYTLKND
437WHb 1.2 5jg8_B precipitant 
WYCFDALHQS
 W->C:(13.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
438SHb 0.0 5jg8_B compound NAG 
SNAYDCVK
 S->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2676070 [MIM:607616]
439WHe 35.1 5jg8_B precipitant 
WEFLSATDQIY
440NHb 3.6 5jg8_B precipitant 
NKQSMRDEWTAGL
441YHb 0.0 5jg8_B 
YLFKTCAGS
442YHb 0.0 5jg8_B 
YFLTEGHAIVS
443RHe 25.3 5jg8_B otherpoly precipitant 
DKRNSQELAGIPTV
444IHb 0.6 5jg8_B precipitant 
ILVKSWADEGNPQRT
445VHb 2.0 5jg8_B 
VFLIMTA
446AHb 3.6 5jg8_B 
RQSHNTAYGKLE
447RHb 9.5 5jg8_B precipitant 
REQKD
448YTb 0.9 5jg8_B precipitant 
YFH
 Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7471433 [MIM:257200]
449ETb 7.5 5jg8_B metal ZN 
RSEQHA
450NTe 30.9 5jg8_B metal ZN 
DNSRT
451TTb 6.5 5jg8_B 
TVI
452LEb 6.7 5jg8_B 
IVL
 L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
453AEb 12.5 5jg8_B 
AIVTEL
 A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
454AEb 3.6 5jg8_B 
GAFQS
 A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1402734 [MIM:607616]
455QEb 0.0 5jg8_B 
QGHSM
456FEb 0.0 5jg8_B 
FLVI
457FEb 0.0 5jg8_B 
YF
458GEb 0.0 5jg8_B 
G
 G->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
459HEb 18.8 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
H
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
460TEb 15.6 5jg8_B compound C5P NT8 PC YA4 precipitant 
MTHIDE
461HEb 8.9 5jg8_B compound PC C5P NT8 RP5 AP2 AMP YA4 metal ZN precipitant 
HN
 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
462VSb 13.3 5jg8_B compound C5P AP2 AMP precipitant 
IRVTYMLS
463D b 5.6 5jg8_B 
DEN
464EEb 6.5 5jg8_B 
HESQKTY
465FEb 2.9 5jg8_B 
FIL
 F->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1319643 [MIM:257200]
466EEb 2.5 5jg8_B 
MSREVTYALDFGIKNPQ
467VEb 0.0 5jg8_B 
VMFIL
468FEb 0.0 5jg8_B 
FLYQIM
469YEb 3.5 5jg8_B 
YSFHLI
 Y->S:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200]
470D b 5.6 5jg8_B 
DEA
471ETe 40.2 5jg8_B 
DEKVNF
472ETe 75.4 5jg8_B 
DNPAEKGILQRSTV
473TTe 52.6 5jg8_B 
TNSKEVPYDGALFIQR
474LSb 18.5 5jg8_B 
LKSDHNPTVAGEFIQRY
475S e 60.9 5jg8_B 
SGTERHALDFIKNPQVY
476RSe 37.2 5jg8_B metal CL 
RNKSITEADFGLPQV
 R->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1828129 [MIM:607616];R->Q:(1.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7635669 [MIM:607616]
477PEb 13.2 5jg8_B 
PDNAEGKLSTV
 P->L:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7535088 [MIM:257200];P->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7535088 [MIM:607616]
478LEb 9.0 5jg8_B 
ITLHVFMAEGKS
479AEb 6.2 5jg8_B 
NSGYAHEKLTV
480VEb 6.7 5jg8_B 
VFSIMAEGKLT
481AEb 0.0 5jg8_B 
MGVNALIEKST
482FEb 2.9 5jg8_B 
FYQWAEGKLSTV
 F->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
483LEb 0.0 5jg8_B 
LIVASTEGK
484AEb 0.0 5jg8_B 
ASTGVEKL
 A->E:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200]
485PEb 1.6 5jg8_B 
PGS
486S b 0.0 5jg8_B 
SAGLV
487ASb 0.0 5jg8_B 
VALDI
 A->V:(43.0 %):LB/B - dbSNP:rs1416412
488TSb 0.0 5jg8_B compound PC precipitant 
TD
 T->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
489T b 0.0 5jg8_B 
TPEN
490YTe 22.2 5jg8_B compound C5P precipitant 
YVSFLWR
 Y->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3981234 [MIM:607616]
491ITe 56.7 5jg8_B compound C5P NT8 precipitant 
IYQKPSDEML
492GTe 20.2 5jg8_B precipitant 
GDNFWYHST
 G->S:(4.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1448733 [MIM:607616]
493L b 4.5 5jg8_B precipitant 
VIQLNHY
494N b 2.4 5jg8_B 
NKEF
 N->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
495P b 0.0 5jg8_B 
P
496GEb 0.0 5jg8_B 
GAKTS
 G->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616]
497YEb 1.7 5jg8_B 
YFIVL
498REb 0.4 5jg8_B 
RVK
 R->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7699047 [MIM:607616];R->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200]
499VEb 0.0 5jg8_B precipitant 
ILVKQ
500YEb 0.0 5jg8_B 
YFS
501QEb 12.2 5jg8_B precipitant 
QETL
502IEb 0.6 5jg8_B 
IFVLAEGSDKNPQRTCHMWY
503DEb 1.9 5jg8_B 
DLAEGSVFIKNPQRTCHMWY
504G b 1.2 5jg8_B 
GASLEVDIKNPRTFQYCHMW
505NSe 45.5 5jg8_B compound NAG otherpoly precipitant 
NQGVLAESDIKPRTFYCHMW
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion."
506YSe 30.0 5jg8_B precipitant 
YHAGLDEFIKNPQRSTV
507STe 89.1 5jg8_B 
DKAPSENFGILQRTV
 S->G:(1.0 %):LB/B -
508GTe 94.0 5jg8_B precipitant 
GPYRSILADEFKNQTV
 G->R:(11.0 %):LB/B - dbSNP:rs1050239
509S b 4.7 5jg8_B 
SAQGRNTLDEFIKPVY
510S b 6.2 5jg8_B 
TSDKAEGILNPRV
 MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" S->F:(0.0 %):LB/B - dbSNP:rs2006526
511H b 2.6 5jg8_B 
YFHKLNGADEIPRSTV
512V b 14.7 5jg8_B 
KNQTVAYSDEGILPR
513VEb 4.0 5jg8_B 
LVIADEGKNPRST
514LEb 19.1 5jg8_B 
LKVTIMADEGNPRS
515DEb 15.4 5jg8_B precipitant 
DEN
516HEb 1.0 5jg8_B 
YMLHIAFS
 H->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
517EEb 3.0 5jg8_B precipitant 
ETVYLPKS
 E->V:(14.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1427870 [MIM:607616]
518TEb 0.0 5jg8_B 
TQAE
519YEb 6.5 5jg8_B precipitant 
YFW
 Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3718372 [MIM:257200]
520IEb 1.2 5jg8_B compound NAG otherpoly 
FYHIPW
 I->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
521LEb 0.0 5jg8_B 
LATESMF
522N e 23.0 5jg8_B compound NAG otherpoly 
ND
 CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
523LHb 0.0 5jg8_B 
LVI
524THe 57.1 5jg8_B compound NAG otherpoly precipitant 
TSYER
525QHe 62.2 5jg8_B compound NAG otherpoly precipitant 
EQDIKS
 Q->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
526AHb 2.7 5jg8_B 
ANES
527NTe 24.2 5jg8_B homo 
NFIT
528ISe 56.7 5jg8_B compound NAG homo 
LAEIMVGS
529PTe 96.1 5jg8_B otherpoly homo precipitant 
KNQTEPSA
530GTe 96.4 5jg8_B homo 
GPDN
531A e 33.9 5jg8_B homo precipitant 
TEKAHNG
532I e 83.0 5jg8_B 
TVIMLKNEAGSCDFHPQRY
533P e 20.2 5jg8_B precipitant 
PSGVDLAEFIKNQRTY
534H e 67.0 5jg8_B compound NAG otherpoly homo 
NRKVEHTISAL
535WEb 7.2 5jg8_B 
WYF
 W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200];W->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616]
536QEe 30.6 5jg8_B compound NAG metal ZN otherpoly 
EQTKSVLY
537L e 31.5 5jg8_B precipitant 
LEKVQR
538L e 25.3 5jg8_B otherpoly 
ELTS
539Y b 4.8 5jg8_B precipitant 
Y
 Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
540RBe 36.4 5jg8_B precipitant 
RDSQNITV
541AHb 0.0 5jg8_B 
ALTF
542RHe 41.1 5jg8_B precipitant 
TRVKN
543EHe 78.9 5jg8_B precipitant 
EQSMN
544THe 31.8 5jg8_B precipitant 
ATIEFLH
545YHb 3.5 5jg8_B 
YFH
546GTe 65.5 5jg8_B 
GNDQS
547L b 2.8 5jg8_B 
IMLVT
548PSe 69.0 5jg8_B 
PDAFKQE
549N e 32.1 5jg8_B 
DNG
 N->K:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
550TSb 1.9 5jg8_B 
LAQFT
551LSe 26.4 5jg8_B 
SQYILTM
 L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
552PHb 19.4 5jg8_B 
PGAV
553THe 48.7 5jg8_B 
TIKLVQHSAE
554AHb 6.2 5jg8_B precipitant 
SGAE
555WHb 1.2 5jg8_B 
WLMY
556HHb 17.8 5jg8_B precipitant 
HNYTDS
557NHe 50.9 5jg8_B 
KDTSGNEQLA
558LHb 0.0 5jg8_B 
LVAM
559VHb 0.7 5jg8_B 
IAVLMYS
560YHe 23.9 5jg8_B precipitant 
QEDYKLNT
561RHe 37.9 5jg8_B 
RQKLN
562MHb 1.4 5jg8_B 
MILF
563RHe 30.0 5jg8_B precipitant 
AKRVTFQNW
564GHe 76.2 5jg8_B precipitant 
TSGKQDI
565D e 42.0 5jg8_B precipitant 
DSNEV
 D->Y:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
566MHe 30.9 5jg8_B precipitant 
STNEDPQM
567QHe 77.0 5jg8_B precipitant 
SKTQH
568LHb 14.6 5jg8_B 
LQIMKT
569FHb 0.0 5jg8_B 
FLR
570QHe 37.2 5jg8_B precipitant 
NQLEIR
571THe 33.1 5jg8_B precipitant 
KDTRNS
572FHb 1.9 5jg8_B 
YF
 F->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200]
573WHb 13.1 5jg8_B 
YHWVAGLSDEFIKNPQRT
574FHe 45.5 5jg8_B compound NAG otherpoly precipitant 
FYEHQRVKN
575LHb 3.9 5jg8_B 
YLVNEHAGST
576YHb 17.8 5jg8_B precipitant 
YFAHN
577HTb 11.5 5jg8_B compound NT8 
NFYHL
 H->D:(0.0 %):US Niemann-Pick disease B (NPDB) [MIM:607616]
578KTb 0.0 5jg8_B 
SRVK
 K->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7473424 [MIM:607616]
579GTe 20.2 5jg8_B compound NAG otherpoly precipitant 
SVNGRA
 G->S:(29.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200]
580H e 34.0 5jg8_B compound NAG homo precipitant 
YSHF
581P e 36.4 5jg8_B homo precipitant 
PDYS
582P e 51.9 5jg8_B compound NAG otherpoly homo precipitant 
PSNGIE
583SSe102.3 5jg8_B homo precipitant 
SKQRTNAH
584ESe 79.4 5jg8_B precipitant 
EAKVLGST
585P e 84.5 5jg8_B precipitant 
PTGSVILADEFKNQRY
586C b 18.7 5jg8_B precipitant 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
587G e 21.4 5jg8_B precipitant 
DGNTYEQ
588THe 55.2 5jg8_B precipitant 
QTSEDGK
589PHe 79.8 5jg8_B metal ZN precipitant 
ASKPTIQHR
590CHe 21.3 5jg8_B precipitant 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
591RHb 8.7 5jg8_B precipitant 
RKQS
592LHe 27.5 5jg8_B precipitant 
LTMIKNYA
593AHe 58.0 5jg8_B 
QAFGIKLDTE
594THb 8.4 5jg8_B 
QYTHLWF
595LHb 0.0 5jg8_B precipitant 
ILVM
596CHe 26.7 5jg8_B 
C
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
597AHe 36.6 5jg8_B 
ADNSK
598QHb 1.0 5jg8_B precipitant 
IMQLN
 Q->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616]
599LHb 0.0 5jg8_B 
LKMRQ
 L->F:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1385319 [MIM:607616]
600S b 19.5 5jg8_B 
SNMKHQD
601A b 0.9 5jg8_B 
AGLVS
602RSb 7.9 5jg8_B precipitant 
RDAHM
 R->H:(13.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3701290 [MIM:257200];R->H:(13.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3701290 [MIM:607616];R->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616]
603ATb 5.4 5jg8_B 
SAHYFIVNL
604DTe 49.4 5jg8_B precipitant 
DNYILV
605S b 8.6 5jg8_B metal ZN precipitant 
SDKAT
 S->G:(0.0 %):LB/B -
606PGe 83.7 5jg8_B precipitant 
YPTED
607AGe 48.2 5jg8_B precipitant 
ATLSYCE
608LGb 5.1 5jg8_B 
LDTYFE
609CGb 12.7 5jg8_B 
CK
 DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8"
610RGe 54.5 5jg8_B 
RDILQAEGKNPSTV
 R->C:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs3759151 [MIM:607616]
611HGe 49.7 5jg8_B precipitant 
HADEGIKLNPRSTV
612LGb 1.1 5jg8_B 
L
613M e 84.5 5jg8_B 
MYV
614P e130.2 5fic_B 
PA
615D---- 
DSN
616G---- 
GA
617S---- 
ST
618L---- 
LT
619P---- 
P
620E---- 
DVE
621A---- 
APV
622Q---- 
QN
623S---- 
SR
624L---- 
L
625W---- 
W
626P---- 
SP
627R---- 
RM
628P---- 
P
629L---- 
L
630F---- 
LF
631C---- 
C