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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
7656 918 161 P40189(IL6RB_HUMAN) RecName: Full=Interleukin-6 receptor subunit beta ; Short=IL-6 receptor subunit beta; Short=IL-6R subunit beta; Short=IL-6R-beta; Short=IL-6RB;AltName: Full=CDw130;AltName: Full=Interleukin-6 signal transducer;AltName: Full=Membrane glycoprotein 130; Short=gp130 ;AltName: Full=Oncostatin-M receptor subunit alpha;AltName: CD_antigen=CD130;Flags: Precursor;
QUERYSEQ 
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR
ETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV
KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG
KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESS
QNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG
MPKSYLPQTVRQGGYMPQ
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All 618523 Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections (HIES4B) LB/B (likely benign or benign)US (uncertain significance)
Number of sites 918 3 5 2
Buired or ExposedBuried 37.5 (%) [221] 66.7 (%) [2] 50.0 (%) [2] 50.0 (%) [1]
Exposed 62.5 (%) [368] 33.3 (%) [1] 50.0 (%) [2] 50.0 (%) [1]
Ave relacc 33.7 % 10.6 % 18.8 % 14.3 %
SD relacc 25.67 % 10.90 % 17.83 % 14.29 %
Contact Molhetero 23.5 (%) [216] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
nucleotide 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
compound 10.1 (%) [93] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
metal 4.9 (%) [45] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
otherpoly 10.0 (%) [92] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
homo 11.7 (%) [107] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
precipitant 19.7 (%) [181] 0.0 (%) [0] 0.0 (%) [0] 0.0 (%) [0]
Number of variants 10 3 5 2
N_Freq(AAvariant)==0 % 33.3 % [1] 20.0 % [1] 50.0 % [1]
N_Freq(AAvariant)>0 % 66.7 % [2] 80.0 % [4] 50.0 % [1]
Ave Freq(AAvariant) 1.0 % 11.0 % 1.5 %
SD Freq(AAvariant) 0.82 % 8.85 % 1.50 %

Site Table for OMIM:618523 Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections (HIES4B) [3 variants]

3 sites 404,498,517
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
404N b 4.2 8d82_F 
NTDPSVAC
 DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" N->Y:(0.0 %):LP/P Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections (HIES4B) [MIM:618523]
498PEb 1.6 8d82_F 
APNVFGRSTL
 DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" P->L:(1.0 %):LP/P Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections (HIES4B) [MIM:618523]
517A e 25.9 8d82_F 
ASLTGKDHMPR
 DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" A->P:(2.0 %):LP/P Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections (HIES4B) [MIM:618523]

Site Table for OMIM:LB/B [5 variants]

5 sites 8,148,397,454,499
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
8L---- 
LVADEFGIKNPQRSTY
 SIGNAL SIGNAL DISORDER predicted by DISOPRED L->V:(26.0 %):LB/B - dbSNP:rs1063560
148G e 27.4 8d82_F 
PGARSTLN
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" G->R:(5.0 %):LB/B - dbSNP:rs2228044
397LEe 43.8 8d82_F 
KLITVEPWASHMNQRY
 DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" L->V:(10.0 %):LB/B - dbSNP:rs2228043
454IEb 0.0 8d82_F 
IVLERFQGKMPS
 DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" I->T:(0.0 %):LB/B - dbSNP:rs2228046
499VEb 4.0 8d82_F 
VILYCFRAMQEST
 DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 4" TOPO_DOM /note="Extracellular" V->I:(14.0 %):LB/B - dbSNP:rs3441793

Site Table for OMIM:US [2 variants]

2 sites 200,415
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
200AEb 0.0 8d82_F 
AIVSDEGPY
 DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 1" TOPO_DOM /note="Extracellular" A->G:(3.0 %):US - dbSNP:rs1999050
415TEe 28.6 8d82_F 
TVESLAGNQRDPFK
 DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" DOMAIN /note="Fibronectin type-III 3" TOPO_DOM /note="Extracellular" T->I:(0.0 %):US A colorectal cancer sample