Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2252372 | 794 | 64 | P09958(FURIN_HUMAN) | RecName: Full=Furin ; EC=3.4.21.75 ;AltName: Full=Dibasic-processing enzyme;AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE;Flags: Precursor; |
QUERYSEQ |
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVS ILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC IIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVY TMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL |
All | LB/B (likely benign or benign) | US (uncertain significance) | ||
Number of sites | 794 | 4 | 1 | |
Buired or Exposed | Buried | 55.5 (%) [276] | 0.0 (%) [0] | 100.0 (%) [1] |
Exposed | 44.5 (%) [221] | 100.0 (%) [2] | 0.0 (%) [0] | |
Ave relacc | 25.4 % | 65.1 % | 2.8 % | |
SD relacc | 27.96 % | 9.18 % | 0.00 % | |
Contact Mol | hetero | 6.3 (%) [50] | 0.0 (%) [0] | 0.0 (%) [0] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 6.5 (%) [52] | 0.0 (%) [0] | 0.0 (%) [0] | |
metal | 5.2 (%) [41] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 2.0 (%) [16] | 25.0 (%) [1] | 0.0 (%) [0] | |
homo | 8.1 (%) [64] | 0.0 (%) [0] | 0.0 (%) [0] | |
precipitant | 12.5 (%) [99] | 25.0 (%) [1] | 0.0 (%) [0] | |
Number of variants | 5 | 4 | 1 | |
N_Freq(AAvariant)==0 % | 0.0 % [0] | 100.0 % [1] | ||
N_Freq(AAvariant)>0 % | 100.0 % [4] | 0.0 % [0] | ||
Ave Freq(AAvariant) | 4.2 % | 0.0 % | ||
SD Freq(AAvariant) | 1.92 % | 0.00 % |
4 sites | 43,146,298,636 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
43 | A | - | - | - | - | AEQDGSVPR |
PROPEP /note="Inhibition peptide" /id="PRO_0000027028" PROPEP /note="Inhibition peptide" /id="PRO_0000027028" | A->V:(5.0 %):LB/B - dbSNP:rs1694497 | |
146 | G | T | e | 56.0 | 5jmo_B | precipitant | GNRS |
DOMAIN /note="Peptidase S8" TOPO_DOM /note="Lumenal" DOMAIN /note="Peptidase S8" TOPO_DOM /note="Lumenal" | G->S:(3.0 %):LB/B - |
298 | R | G | e | 74.3 | 5jmo_B | otherpoly | RASHKLNQPVEMTDFGIY |
DOMAIN /note="Peptidase S8" TOPO_DOM /note="Lumenal" DOMAIN /note="Peptidase S8" TOPO_DOM /note="Lumenal" | R->Q:(7.0 %):LB/B - |
636 | I | - | - | - | - | LSIQAEGKTVCDFHMNPRY |
TOPO_DOM /note="Lumenal" TOPO_DOM /note="Lumenal" | I->V:(2.0 %):LB/B - |
1 sites | 547 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
547 | W | E | b | 2.8 | 5jmo_B | WY |
DOMAIN /note="P/Homo B" TOPO_DOM /note="Lumenal" DOMAIN /note="P/Homo B" TOPO_DOM /note="Lumenal" | W->R:(0.0 %):US - |