Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2692367 | 631 | 7 | P17405(ASM_HUMAN) | RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor; |
QUERYSEQ |
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR SVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYEN TLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS ARADSPALCRHLMPDGSLPEAQSLWPRPLFC |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
1 | M | - | - | - | - | M |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
2 | P | - | - | - | - | P |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
3 | R | - | - | - | - | RH |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
4 | Y | - | - | - | - | HY |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
5 | G | - | - | - | - | GR |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
6 | A | - | - | - | - | AV |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
7 | S | - | - | - | - | S |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
8 | L | - | - | - | - | SLP |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
9 | R | - | - | - | - | GR |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
10 | Q | - | - | - | - | Q |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
11 | S | - | - | - | - | DGS |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
12 | C | - | - | - | - | HCL |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
13 | P | - | - | - | - | PL |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
14 | R | - | - | - | - | R |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
15 | S | - | - | - | - | SA |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
16 | G | - | - | - | - | G |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
17 | R | - | - | - | - | RW |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
18 | E | - | - | - | - | E |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
19 | Q | - | - | - | - | Q |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
20 | G | - | - | - | - | RAG |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
21 | Q | - | - | - | - | LQS |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
22 | D | - | - | - | - | DE |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
23 | G | - | - | - | - | RG |
REGION /note="Disordered" SIGNAL REGION /note="Disordered" DISORDER predicted by DISOPRED SIGNAL | ||
24 | T | - | - | - | - | ST |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | ||
25 | A | - | - | - | - | LA |
SIGNAL DISORDER predicted by DISOPRED SIGNAL | ||
26 | G | - | - | - | - | GP |
SIGNAL SIGNAL | ||
27 | A | - | - | - | - | A |
SIGNAL SIGNAL | ||
28 | P | - | - | - | - | P |
SIGNAL SIGNAL | ||
29 | G | - | - | - | - | GALDEIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
30 | L | - | - | - | - | LADEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
31 | L | - | - | - | - | LADEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
32 | W | - | - | - | - | WALDEGIKPRSTVCFHMNQY |
SIGNAL SIGNAL | ||
33 | M | - | - | - | - | MALDEGIKPRSTVCFHNQY |
SIGNAL SIGNAL | ||
34 | G | - | - | - | - | GLASDEKTVFINPQRMYCHW |
SIGNAL SIGNAL | ||
35 | L | - | - | - | - | ILCAGSDEFKNPQRTVY |
SIGNAL SIGNAL | ||
36 | V | - | - | - | - | ILVAGSDEFKNPQRTY |
SIGNAL SIGNAL | V->A:(2.0 %):LB/B - dbSNP:rs1050228 | |
37 | L | - | - | - | - | LRAGSDEFIKNPQTVY |
SIGNAL SIGNAL | ||
38 | A | - | - | - | - | GLASDEFIKNPQRTVY |
SIGNAL SIGNAL | ||
39 | L | - | - | - | - | LIAGSDEFKNPQRTVY |
SIGNAL SIGNAL | ||
40 | A | - | - | - | - | GAW |
SIGNAL SIGNAL | ||
41 | L | - | - | - | - | LI |
SIGNAL SIGNAL | ||
42 | A | - | - | - | - | GVA |
SIGNAL SIGNAL | ||
43 | L | - | - | - | - | L |
SIGNAL SIGNAL | ||
44 | A | - | - | - | - | A |
SIGNAL SIGNAL | ||
45 | L | - | - | - | - | L |
SIGNAL SIGNAL | ||
46 | A | - | - | - | - | VA |
SIGNAL SIGNAL | ||
47 | L | - | - | - | - | LS |
|||
48 | A | - | - | - | - | AN |
|||
49 | L | - | - | - | - | LV |
|||
50 | S | - | - | - | - | FPSAGLDEIKNQRTVCHMY |
|||
51 | D | - | - | - | - | DEN |
D->V:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7485899 [MIM:607616] | ||
52 | S | - | - | - | - | S |
|||
53 | R | - | - | - | - | GPRT |
|||
54 | V | - | - | - | - | V |
|||
55 | L | - | - | - | - | L |
|||
56 | W | - | - | - | - | WR |
|||
57 | A | - | - | - | - | KASV |
|||
58 | P | - | - | - | - | P |
|||
59 | A | - | - | - | - | AV |
|||
60 | E | - | - | - | - | EDR |
|||
61 | A | - | - | - | - | AE |
|||
62 | H | - | - | - | - | HRY |
|||
63 | P | - | - | - | - | PE |
|||
64 | L | - | - | - | - | LY |
|||
65 | S | - | - | - | - | PNS |
|||
66 | P | - | - | - | - | APST |
|||
67 | Q | - | - | - | - | QRE |
|||
68 | G | - | - | - | - | G |
|||
69 | H | - | - | - | - | HN |
|||
70 | P | - | - | - | - | PES |
|||
71 | A | - | - | - | - | AV |
|||
72 | R | - | - | - | - | KR |
|||
73 | L | - | - | - | - | FML |
|||
74 | H | - | - | - | - | LHIS |
|||
75 | R | - | - | - | - | RA |
|||
76 | I | - | - | - | - | IY |
|||
77 | V | - | - | - | - | AV |
|||
78 | P | - | - | - | - | PK |
|||
79 | R | - | - | - | - | KPQR |
|||
80 | L | - | - | - | - | LA |
|||
81 | R | - | - | - | - | QIR |
|||
82 | D | - | - | - | - | DNES |
|||
83 | V | - | - | - | - | AKEV |
|||
84 | F | e | 114.4 | 5jg8_B | compound NAG homo | FYP |
|||
85 | G | e | 78.6 | 5jg8_B | compound NAG | GE |
|||
86 | W | G | e | 78.1 | 5jg8_B | compound NAG homo | WFN |
||
87 | G | G | e | 54.8 | 5jg8_B | QRGW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
88 | N | G | e | 73.3 | 5jg8_B | compound NAG homo | NPK |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type" CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." DOMAIN /note="Saposin B-type" | |
89 | L | T | e | 55.6 | 5jg8_B | homo | LM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
90 | T | H | e | 30.5 | 5jg8_B | STAGLDEFIKNPQRVY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
91 | C | H | e | 20.7 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
92 | P | H | e | 56.6 | 5jg8_B | homo | DPEIL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
93 | I | H | e | 62.6 | 5jg8_B | homo | IVESFAT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
94 | C | H | b | 10.7 | 5jg8_B | homo | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] |
95 | K | H | e | 41.0 | 5jg8_B | homo | KTQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
96 | G | H | e | 48.8 | 5jg8_B | homo | GFISV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
97 | L | H | e | 57.3 | 5jg8_B | homo | LGIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
98 | F | H | b | 15.3 | 5jg8_B | homo | IVFA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
99 | T | H | e | 43.5 | 5jg8_B | homo | SDTN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
100 | A | H | e | 61.6 | 5jg8_B | homo | LAQVG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
101 | I | H | e | 41.5 | 5jg8_B | homo | LVIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
102 | N | H | b | 16.4 | 5jg8_B | QNESD |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
103 | L | H | e | 50.6 | 5jg8_B | FDKAHL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
104 | G | H | e | 34.5 | 5jg8_B | FGEML |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
105 | L | H | b | 16.3 | 5jg8_B | homo | ILW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7512695 [MIM:257200];L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7512695 [MIM:607616] |
106 | K | T | e | 58.5 | 5jg8_B | KAGR |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
107 | K | S | e | 54.7 | 5jg8_B | precipitant | KEFSQN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
108 | E | H | e | 61.3 | 5jg8_B | KNEDQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
109 | P | H | e | 60.5 | 5jg8_B | APKQVS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
110 | N | H | e | 34.5 | 5jg8_B | homo precipitant | STNG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
111 | V | H | b | 6.0 | 5jg8_B | EVLID |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
112 | A | H | e | 44.6 | 5jg8_B | EATPN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
113 | R | H | e | 58.5 | 5jg8_B | ERCDVW |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
114 | V | H | e | 44.0 | 5jg8_B | homo | IV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
115 | G | H | b | 3.6 | 5jg8_B | GILMSA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
116 | S | H | e | 44.5 | 5jg8_B | KESA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
117 | V | H | e | 54.7 | 5jg8_B | homo | FVGIY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
118 | A | H | e | 36.6 | 5jg8_B | homo | AL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
119 | I | H | b | 10.5 | 5jg8_B | IVST |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
120 | K | H | e | 70.8 | 5jg8_B | DKFIN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
121 | L | H | e | 52.8 | 5jg8_B | homo | LIV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
122 | C | H | e | 25.3 | 5jg8_B | homo | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | |
123 | N | H | e | 40.6 | 5jg8_B | KIETDNV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
124 | L | H | e | 69.7 | 5jg8_B | LATYM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
125 | L | H | e | 74.7 | 5jg8_B | FLS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
126 | K | e | 70.3 | 5jg8_B | compound NAG | KHADN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
127 | I | e | 89.5 | 5jg8_B | compound NAG homo | IEKV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
128 | A | S | b | 19.6 | 5jg8_B | EAQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
129 | P | e | 34.1 | 5jg8_B | PQDK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |||
130 | P | H | e | 64.3 | 5jg8_B | PANWL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
131 | A | H | e | 59.8 | 5jg8_B | AEDH |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
132 | V | H | b | 10.0 | 5jg8_B | V |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | V->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
133 | C | H | b | 2.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | ||
134 | Q | H | e | 52.0 | 5jg8_B | precipitant | NQTDK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
135 | S | H | e | 36.7 | 5jg8_B | precipitant | GSFN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
136 | I | H | e | 25.7 | 5jg8_B | homo | IAL |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
137 | V | H | b | 13.3 | 5jg8_B | homo | IVLS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
138 | H | H | e | 48.2 | 5jg8_B | precipitant | SHNPYQ |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
139 | L | H | e | 24.2 | 5jg8_B | otherpoly | LNDQA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616] |
140 | F | H | b | 19.6 | 5jg8_B | homo | FY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
141 | E | H | b | 15.1 | 5jg8_B | EVARSK |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
142 | D | H | e | 40.7 | 5jg8_B | precipitant | DPN |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
143 | D | H | b | 18.5 | 5jg8_B | EDIM |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
144 | M | H | e | 24.2 | 5jg8_B | homo | FVMIT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
145 | V | H | b | 16.7 | 5jg8_B | homo | VFMY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
146 | E | H | e | 20.1 | 5jg8_B | YEDNF |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
147 | V | H | b | 0.0 | 5jg8_B | V |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
148 | W | H | e | 47.0 | 5jg8_B | homo | LWFI |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
149 | R | H | b | 9.9 | 5jg8_B | RTIKSE |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
150 | R | H | e | 36.0 | 5jg8_B | precipitant | RQY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
151 | S | T | b | 2.3 | 5jg8_B | SAIP |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type" MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD." DOMAIN /note="Saposin B-type" | ||
152 | V | T | b | 19.3 | 5jg8_B | homo | VDLNT |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
153 | L | S | e | 22.5 | 5jg8_B | homo | FVLE |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
154 | S | S | e | 21.9 | 5jg8_B | TS |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
155 | P | T | e | 27.1 | 5jg8_B | PG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
156 | S | T | b | 18.0 | 5jg8_B | SEH |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
157 | E | T | b | 8.5 | 5jg8_B | QEY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
158 | A | H | b | 7.1 | 5jg8_B | LIAV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
159 | C | H | b | 0.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7275041 [MIM:607616] | |
160 | G | H | b | 9.5 | 5jg8_B | G |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
161 | L | H | e | 56.7 | 5jg8_B | homo | LYFIA |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
162 | L | H | e | 64.0 | 5jg8_B | homo | LFIV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |
163 | L | T | e | 46.1 | 5jg8_B | LIMADEFGKNPQRSTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | L->P:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7801344 [MIM:607616] | |
164 | G | B | b | 17.9 | 5jg8_B | GCKPADEFILNQRSTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
165 | S | T | e | 89.8 | 5jg8_B | SNDG |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
166 | T | T | e | 92.9 | 5jg8_B | SADFCTEGIKLNPQRV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
167 | C | B | b | 1.3 | 5jg8_B | CTA |
DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" DISULFID ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DOMAIN /note="Saposin B-type" | ||
168 | G | b | 17.9 | 5jg8_B | GDP |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | G->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1847910 [MIM:607616] | ||
169 | H | e | 68.6 | 5jg8_B | HSDPY |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |||
170 | W | e | 37.8 | 5jg8_B | SWFTV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | |||
171 | D | e | 35.8 | 5jg8_B | compound NAG otherpoly | DNPV |
DOMAIN /note="Saposin B-type" DOMAIN /note="Saposin B-type" | ||
172 | I | T | b | 12.9 | 5jg8_B | LIERS |
|||
173 | F | T | e | 46.4 | 5jg8_B | FYAENT |
|||
174 | S | e | 34.4 | 5jg8_B | precipitant | SRTH |
|||
175 | S | e | 70.3 | 5jg8_B | compound NAG precipitant | SQGIMT |
|||
176 | W | b | 9.6 | 5jg8_B | compound NAG | WEADFGIKLNPQRSTV |
|||
177 | N | e | 74.5 | 5jg8_B | compound NAG otherpoly | NSM |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." | ||
178 | I | b | 5.3 | 5jg8_B | otherpoly | ILFMV |
I->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7497807 [MIM:607616] | ||
179 | S | e | 60.2 | 5jg8_B | otherpoly | STGNAI |
|||
180 | L | e | 22.5 | 5jg8_B | LIKN |
||||
181 | P | e | 34.9 | 5jg8_B | PGF |
||||
182 | T | S | e | 94.2 | 5jg8_B | GPTLVAS |
|||
183 | V | S | e | 38.0 | 5jg8_B | KVTAMGLDEFINPQRSY |
|||
184 | P | e | 84.5 | 5jg8_B | PKNG |
DISORDER predicted by DISOPRED | |||
185 | K | e | 35.8 | 5jg8_B | KANQ |
DISORDER predicted by DISOPRED | |||
186 | P | e | 34.1 | 5jg8_B | PGQR |
DISORDER predicted by DISOPRED | P->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1057517 [MIM:257200] | ||
187 | P | e | 86.0 | 5jg8_B | PGKQT |
DISORDER predicted by DISOPRED | |||
188 | P | e | 60.5 | 5jg8_B | PLRVFSYHI |
DISORDER predicted by DISOPRED | |||
189 | K | e | 59.4 | 5jg8_B | precipitant | KVNQ |
DISORDER predicted by DISOPRED | ||
190 | P | e | 64.3 | 5jg8_B | PIDK |
DISORDER predicted by DISOPRED | |||
191 | P | e | 44.2 | 5jg8_B | PKLTVW |
DISORDER predicted by DISOPRED | |||
192 | S | e | 65.6 | 5jg8_B | precipitant | SVKLDPQA |
DISORDER predicted by DISOPRED | ||
193 | P | e | 90.7 | 5jg8_B | PAGIKNQV |
DISORDER predicted by DISOPRED | |||
194 | P | e | 39.5 | 5jg8_B | PGKQVIA |
DISORDER predicted by DISOPRED | |||
195 | A | e | 58.0 | 5jg8_B | ASPGDEK |
DISORDER predicted by DISOPRED | |||
196 | P | T | e | 104.7 | 5jg8_B | PKDETIY |
DISORDER predicted by DISOPRED | ||
197 | G | T | e | 106.0 | 5jg8_B | GNEQR |
|||
198 | A | e | 25.0 | 5jg8_B | AKSVDMNP |
A->P:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970447 [MIM:607616] | |||
199 | P | e | 51.2 | 5jg8_B | PSLQA |
||||
200 | V | E | e | 48.7 | 5jg8_B | VTIHLM |
|||
201 | S | E | b | 1.6 | 5jg8_B | GSKLFM |
|||
202 | R | E | b | 19.0 | 5jg8_B | RQKY |
R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7495952 [MIM:607616] | ||
203 | I | E | b | 1.2 | 5jg8_B | FVIA |
|||
204 | L | E | b | 0.0 | 5jg8_B | LW |
|||
205 | F | E | b | 0.5 | 5jg8_B | HQF |
|||
206 | L | E | b | 1.1 | 5jg8_B | ILV |
|||
207 | T | b | 1.9 | 5jg8_B | TSA |
||||
208 | D | b | 0.0 | 5jg8_B | compound PC metal ZN precipitant | D |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | ||
209 | L | b | 3.9 | 5jg8_B | LIMTVF |
||||
210 | H | b | 0.0 | 5jg8_B | compound PC metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | ||
211 | W | B | b | 6.8 | 5jg8_B | PLVWFIY |
W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
212 | D | b | 3.1 | 5jg8_B | D |
||||
213 | H | S | e | 42.4 | 5jg8_B | PHFIMQKLE |
|||
214 | D | e | 25.9 | 5jg8_B | YDTFELMQVN |
||||
215 | Y | B | b | 5.7 | 5jg8_B | Y |
|||
216 | L | e | 24.7 | 5jg8_B | KVETLIHADGPS |
L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
217 | E | T | e | 39.7 | 5jg8_B | EVHKPYSTAI |
|||
218 | G | T | e | 41.7 | 5jg8_B | GISHPNT |
|||
219 | T | S | b | 3.9 | 5jg8_B | STGKLAM |
|||
220 | D | b | 8.6 | 5jg8_B | DESNAFGIKLPQRTV |
||||
221 | P | S | b | 4.7 | 5jg8_B | APITEVLDGKSCFHMNQRY |
|||
222 | D | S | e | 46.9 | 5jg8_B | DNYAGLFEIKPQRSTV |
|||
223 | C | b | 13.3 | 5jg8_B | CSQEHTGKDR |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |||
224 | A | S | e | 63.4 | 5jg8_B | AGTVIDQEFKLNPRS |
|||
225 | D | S | e | 24.7 | 5jg8_B | DKCTERYHNALFGIPQSV |
MUTAGEN /note="D->A: Does not affect cleavage by CASP7." MUTAGEN /note="D->A: Does not affect cleavage by CASP7." | ||
226 | P | S | e | 34.9 | 5jg8_B | homo | PAVHTNEGKLSCDFIMQRY |
||
227 | L | S | b | 0.0 | 5jg8_B | LVCYQKMAGDEINPRSTFH |
L->M:(6.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616];L->P:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7643179 [MIM:607616] | ||
228 | C | b | 0.0 | 5jg8_B | CALTVDEFGIKNPQRSY |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1564923 [MIM:257200] | ||
229 | C | S | b | 0.0 | 5jg8_B | CSYLADEFGIKNPQRTV |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
230 | R | B | b | 2.4 | 5jg8_B | RHSDALEFGIKNPQTVY |
R->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs9896392 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs9896392 [MIM:607616];R->H:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1413877 [MIM:257200] | ||
231 | R | T | e | 65.2 | 5jg8_B | RDKSEGHPVALFINQTY |
|||
232 | G | T | e | 92.9 | 5jg8_B | GSHDNQPVY |
|||
233 | S | S | b | 10.9 | 5jg8_B | SKAVTDNP |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." | ||
234 | G | e | 54.8 | 5jg8_B | GNDAMSY |
G->D:(7.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |||
235 | L | e | 78.7 | 5jg8_B | EKSDANRLVPWGIQTCFHMY |
||||
236 | P | e | 20.2 | 5jg8_B | homo | PQTVDSAEGLFHIKMNRY |
|||
237 | P | e | 63.6 | 5jg8_B | homo precipitant | PEKSTAGLVCDFHIMNQRY |
|||
238 | A | T | e | 98.2 | 5jg8_B | homo precipitant | AVNKLISYGDEFPQRT |
||
239 | S | T | e | 90.6 | 5jg8_B | homo | SGDLEVKAFINPQRTY |
||
240 | R | e | 32.4 | 5jg8_B | KENRQGDALFIPSTVY |
||||
241 | P | e | 76.7 | 5jg8_B | PDKSGNYAEFILQRTV |
||||
242 | G | e | 33.3 | 5jg8_B | GAKRTSVDN |
||||
243 | A | b | 8.0 | 5jg8_B | APNGVD |
A->V:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1291958 [MIM:257200] | |||
244 | G | b | 13.1 | 5jg8_B | GAVPSDEIKLNRT |
G->R:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | |||
245 | Y | T | e | 50.0 | 5jg8_B | YPKRLESVFADGINT |
|||
246 | W | T | b | 16.3 | 5jg8_B | WFYILG |
W->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
247 | G | b | 0.0 | 5jg8_B | GA |
G->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs5877794 [MIM:257200];G->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5877794 [MIM:607616];G->D:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1590739 [MIM:257200] | |||
248 | E | b | 18.6 | 5jg8_B | DEHNSRPMKT |
E->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2007634 [MIM:607616];E->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2007634 [MIM:257200] | |||
249 | Y | S | b | 13.0 | 5jg8_B | homo | YVMGALPDEKST |
||
250 | S | S | e | 29.7 | 5jg8_B | SGYVMLADEIKPRTCFHNQ |
MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." MUTAGEN /note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." | S->R:(2.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7507798 [MIM:257200];S->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7507798 [MIM:607616] | |
251 | K | S | e | 25.5 | 5jg8_B | LKGDSEMAIPRTV |
|||
252 | C | b | 0.0 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |||
253 | D | b | 0.0 | 5jg8_B | D |
MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" MUTAGEN /note="D->A: Abolished cleavage by CASP7." SITE /note="Cleavage; by CASP7" | D->E:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];D->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3981234 [MIM:257200] | ||
254 | L | B | b | 0.0 | 5jg8_B | SLTIGAC |
SITE /note="Cleavage; by CASP7" SITE /note="Cleavage; by CASP7" | ||
255 | P | b | 4.7 | 5jg8_B | PNIS |
P->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
256 | L | H | e | 35.4 | 5jg8_B | YFMLQWDIV |
|||
257 | R | H | e | 20.2 | 5jg8_B | AQSRLWKEDIVY |
|||
258 | T | H | b | 0.0 | 5jg8_B | LTM |
T->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
259 | L | H | b | 1.7 | 5jg8_B | LIMVF |
|||
260 | E | H | e | 54.8 | 5jg8_B | ENLDSQTF |
|||
261 | S | H | b | 14.8 | 5jg8_B | SENAWLDIYM |
|||
262 | L | H | b | 2.2 | 5jg8_B | TAMLSIV |
|||
263 | L | H | b | 5.6 | 5jg8_B | LFIKMH |
|||
264 | S | H | e | 63.3 | 5jg8_B | homo | DSKEQYAR |
||
265 | G | T | e | 34.5 | 5jg8_B | WHFNGAEY |
|||
266 | L | T | b | 7.3 | 5jg8_B | ILMVQ |
|||
267 | G | S | e | 66.7 | 5jg8_B | homo | KADGLNSV |
||
268 | P | S | e | 78.3 | 5jg8_B | homo | ENKTPQADS |
||
269 | A | S | e | 32.1 | 5jg8_B | ASTKVNIHGR |
|||
270 | G | b | 10.7 | 5jg8_B | homo | DGENHK |
|||
271 | P | e | 82.2 | 5jg8_B | homo | EKPDQSGM |
|||
272 | F | b | 12.4 | 5jg8_B | ILAFKNVE |
||||
273 | D | S | e | 45.1 | 5jg8_B | precipitant | DSE |
||
274 | M | E | b | 4.8 | 5jg8_B | FMYI |
|||
275 | V | E | b | 0.0 | 5jg8_B | IVM |
|||
276 | Y | E | b | 0.0 | 5jg8_B | IVLYMF |
|||
277 | W | E | b | 0.8 | 5jg8_B | WYIMV |
|||
278 | T | b | 0.6 | 5jg8_B | TS |
||||
279 | G | b | 2.4 | 5jg8_B | G |
||||
280 | D | b | 0.6 | 5jg8_B | compound PC metal ZN precipitant | D |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | D->A:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |
281 | I | b | 1.2 | 5jg8_B | NDSIGFLTY |
||||
282 | P | B | b | 3.1 | 5jg8_B | PAVITES |
P->F:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
283 | A | b | 3.6 | 5jg8_B | RPAGNS |
A->T:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7521485 [MIM:607616] | |||
284 | H | S | b | 11.0 | 5jg8_B | compound PC metal ZN precipitant | H |
||
285 | D | b | 9.3 | 5jg8_B | DVNGLT |
||||
286 | V | b | 17.3 | 5jg8_B | homo | VINPSRLDGT |
|||
287 | W | S | b | 9.6 | 5jg8_B | WDYNVKLPR |
|||
288 | H | S | e | 40.8 | 5jg8_B | EPHSRADNQL |
|||
289 | Q | b | 3.1 | 5jg8_B | otherpoly | QRYELGHKMPS |
|||
290 | T | e | 39.0 | 5jg8_B | otherpoly | STLFVINR |
|||
291 | R | H | e | 27.3 | 5jg8_B | otherpoly | PEQTRGSINAY |
R->H:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1803161 [MIM:607616] | |
292 | Q | H | e | 78.6 | 5jg8_B | EQRDGTASL |
|||
293 | D | H | e | 24.1 | 5jg8_B | TDAENQSLG |
|||
294 | Q | H | b | 4.6 | 5jg8_B | QIAVHTPKGL |
Q->K:(4.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | ||
295 | L | H | e | 27.5 | 5jg8_B | LFISVDEKRAG |
|||
296 | R | H | e | 33.2 | 5jg8_B | ERFQLDNSYGIKA |
R->Q:(10.0 %):LB/B - dbSNP:rs3582445 | ||
297 | A | H | b | 5.4 | 5jg8_B | AVMINESDYGL |
|||
298 | L | H | b | 1.7 | 5jg8_B | LINVMFTSAG |
|||
299 | T | H | e | 45.5 | 5jg8_B | TAQNRGKDFEVL |
|||
300 | T | H | e | 32.5 | 5jg8_B | NTSQERKLIAG |
|||
301 | V | H | b | 0.7 | 5jg8_B | LVMNIQAG |
|||
302 | T | H | b | 2.6 | 5jg8_B | TSRAEHQV |
|||
303 | A | H | e | 52.7 | 5jg8_B | NDTEARMQWKSV |
|||
304 | L | H | b | 14.0 | 5jg8_B | LTIVKDM |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | ||
305 | V | H | b | 0.0 | 5jg8_B | VIAFGMT |
|||
306 | R | H | e | 50.6 | 5jg8_B | KQDRLNEHY |
|||
307 | K | H | e | 70.3 | 5jg8_B | homo | KESNRGLT |
||
308 | F | H | e | 32.5 | 5jg8_B | homo | LMTYFV |
||
309 | L | H | b | 9.6 | 5jg8_B | FLYAIQSR |
|||
310 | G | T | e | 36.9 | 5jg8_B | PGEKADRT |
|||
311 | P | T | e | 103.1 | 5jg8_B | homo | DNKPSAEGV |
||
312 | V | S | e | 22.0 | 5jg8_B | homo | VTILYM |
||
313 | P | e | 31.8 | 5jg8_B | PKQS |
||||
314 | V | E | b | 0.0 | 5jg8_B | VIFL |
V->M:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1228068 [MIM:607616] | ||
315 | Y | E | b | 6.5 | 5jg8_B | YVFIL |
Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
316 | P | E | b | 0.8 | 5jg8_B | PAFSVW |
|||
317 | A | b | 1.8 | 5jg8_B | AST |
||||
318 | V | b | 0.7 | 5jg8_B | LIV |
V->E:(0.0 %):LB/B - dbSNP:rs1257513 | |||
319 | G | b | 0.0 | 5jg8_B | G |
G->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7579347 [MIM:257200] | |||
320 | N | S | b | 1.2 | 5jg8_B | compound PC metal ZN precipitant | N |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | N->D:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7799276 [MIM:607616] |
321 | H | S | b | 9.9 | 5jg8_B | compound PC precipitant | HN |
H->Y:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |
322 | E | S | b | 2.5 | 5jg8_B | DE |
|||
323 | S | S | b | 1.6 | 5jg8_B | VSGIYFA |
|||
324 | T | S | b | 7.8 | 5jg8_B | FYVWLTHAG |
T->I:(0.0 %):LB/B - dbSNP:rs1050233;T->P:(0.0 %):US Niemann-Pick disease A (NPDA) [MIM:257200] | ||
325 | P | S | b | 1.6 | 5jg8_B | PAGL |
P->A:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7613082 [MIM:607616] | ||
326 | V | T | b | 10.7 | 5jg8_B | HVQKAGL |
|||
327 | N | T | b | 7.3 | 5jg8_B | homo | NDHAGL |
||
328 | S | b | 2.3 | 5jg8_B | QLSMAGINDEFKPRTVY |
||||
329 | F | b | 0.0 | 5jg8_B | FLIYMADEGKPSTV |
||||
330 | P | b | 2.3 | 5jg8_B | PASGLVDEFIKNQRT |
||||
331 | P | b | 0.8 | 5jg8_B | PVGADILEFKNQRST |
||||
332 | P | T | e | 38.8 | 5jg8_B | PHYSLAEGVDFIKNQRTCMW |
P->R:(2.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2020819 [MIM:607616] | ||
333 | F | T | e | 41.6 | 5jg8_B | precipitant | TFNISALEGKVDPQRCHMWY |
||
334 | I | S | b | 2.9 | 5jg8_B | precipitant | LVMISTAEGKDFNPQRCHWY |
||
335 | E | e | 77.4 | 5jg8_B | precipitant | QEKLPDYAGSTVFINRCHMW |
|||
336 | G | S | e | 46.4 | 5jg8_B | GAECDKLSVIPRTFNQYHMW |
|||
337 | N | S | e | 75.8 | 5jg8_B | otherpoly | NGAKPRSTLDEIVFQYCHMW |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." | |
338 | H | S | e | 31.9 | 5jg8_B | otherpoly precipitant | QDLGPFNRYAHEKSTVICMW |
||
339 | S | S | b | 7.0 | 5jg8_B | SGVHNPWAQDEFIKLRT |
|||
340 | S | S | b | 3.1 | 5jg8_B | STPNMR |
|||
341 | R | H | e | 48.6 | 5jg8_B | RQSNTDHAEGIKLPV |
|||
342 | W | H | b | 12.7 | 5jg8_B | WEKFLNRADGIPQSTV |
|||
343 | L | H | b | 1.1 | 5jg8_B | LIVMY |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];L->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
344 | Y | H | b | 2.2 | 5jg8_B | YTFLAEGKSV |
|||
345 | E | H | e | 45.7 | 5jg8_B | ENKRDSQAFGILPTV |
|||
346 | A | H | b | 17.0 | 5jg8_B | AQEITHSNDFGKLPRV |
|||
347 | M | T | b | 0.0 | 5jg8_B | MVLFIYAGSDEKNPQRT |
|||
348 | A | T | b | 3.6 | 5jg8_B | ASLQTYGDEFIKNPRV |
|||
349 | K | T | e | 78.8 | 5jg8_B | ENRTKQDGHLYAIPSV |
|||
350 | A | S | b | 19.6 | 5jg8_B | LIAMDYEGKPRSTV |
|||
351 | W | S | b | 0.8 | 5jg8_B | WS |
|||
352 | E | T | e | 55.8 | 5jg8_B | KSAREGDQH |
|||
353 | P | T | e | 41.1 | 5jg8_B | PDQHAGREKN |
|||
354 | W | T | b | 10.8 | 5jg8_B | WFL |
|||
355 | L | S | b | 3.4 | 5jg8_B | LIV |
|||
356 | P | e | 48.8 | 5jg8_B | PSDNGT |
||||
357 | A | H | e | 61.6 | 5jg8_B | EANQTYPSV |
|||
358 | E | H | e | 62.8 | 5jg8_B | EDANGQ |
|||
359 | A | H | b | 0.0 | 5jg8_B | QASE |
A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7970448 [MIM:607616] | ||
360 | L | H | b | 7.3 | 5jg8_B | LIQRVEKAY |
|||
361 | R | H | e | 58.5 | 5jg8_B | HSRADEKNQT |
|||
362 | T | H | b | 14.3 | 5jg8_B | TSLIANVM |
|||
363 | L | H | b | 0.0 | 5jg8_B | FLV |
L->R:(0.0 %):US Niemann-Pick disease A (NPDA) [MIM:257200] | ||
364 | R | H | e | 41.5 | 5jg8_B | KERQLDNS |
|||
365 | I | H | e | 51.5 | 5jg8_B | RKYIEFLH |
|||
366 | G | T | b | 1.2 | 5jg8_B | GRDNSY |
|||
367 | G | S | b | 0.0 | 5jg8_B | GAST |
|||
368 | F | b | 6.2 | 5jg8_B | SYFCW |
||||
369 | Y | E | b | 0.4 | 5jg8_B | YF |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3722878 [MIM:257200] | ||
370 | A | E | b | 7.1 | 5jg8_B | SFTALVMYC |
|||
371 | L | E | b | 5.1 | 5jg8_B | VTELKCSQ |
|||
372 | S | e | 50.8 | 5jg8_B | ESKLADQTYP |
||||
373 | P | S | b | 16.3 | 5jg8_B | compound NAG otherpoly | VPISANT |
P->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1342372 [MIM:607616] | |
374 | Y | S | b | 7.4 | 5jg8_B | compound NAG otherpoly precipitant | ISNKYVMRQ |
||
375 | P | T | e | 79.1 | 5jg8_B | compound NAG | PSDEGRT |
||
376 | G | T | e | 44.0 | 5jg8_B | GDNAK |
|||
377 | L | E | b | 0.6 | 5jg8_B | LGF |
|||
378 | R | E | b | 13.0 | 5jg8_B | RAKT |
R->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs5590880 [MIM:607616];R->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
379 | L | E | b | 0.0 | 5jg8_B | VILAM |
|||
380 | I | E | b | 0.0 | 5jg8_B | ILVFM |
|||
381 | S | E | b | 0.8 | 5jg8_B | SVT |
S->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
382 | L | b | 0.0 | 5jg8_B | LIF |
||||
383 | N | b | 0.0 | 5jg8_B | N |
||||
384 | M | G | b | 0.0 | 5jg8_B | TMN |
M->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];M->I:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | ||
385 | N | G | b | 0.0 | 5jg8_B | LNIVG |
N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616] | ||
386 | F | G | b | 0.0 | 5jg8_B | YLFEW |
|||
387 | C | G | b | 0.0 | 5jg8_B | YCLFGNMW |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |
388 | S | b | 1.6 | 5jg8_B | YFSDEN |
||||
389 | R | S | e | 47.4 | 5jg8_B | KNRVGDEMQST |
|||
390 | E | S | e | 59.3 | 5jg8_B | homo | SAEKPIGFRTN |
||
391 | N | b | 0.6 | 5jg8_B | N |
N->T:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200];N->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
392 | F | G | b | 11.5 | 5jg8_B | homo | FAIPKLRTGSDENQVY |
||
393 | W | G | b | 0.0 | 5jg8_B | YWANGLEFQMPSKTVCDHIR |
W->G:(7.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];W->R:(1.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
394 | L | G | b | 0.6 | 5jg8_B | LVTPMCNQS |
|||
395 | L | G | b | 17.4 | 5jg8_B | LTYCVFDAR |
|||
396 | I | T | b | 18.1 | 5jg8_B | DLVAISE |
|||
397 | N | e | 45.5 | 5jg8_B | compound NAG otherpoly | NDTPSEGH |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." | ||
398 | S | b | 7.0 | 5jg8_B | NKSQPMELTC |
||||
399 | T | S | e | 37.0 | 5jg8_B | otherpoly | TCSKNAQLV |
||
400 | D | S | b | 9.9 | 5jg8_B | DEGNS |
|||
401 | P | G | b | 3.9 | 5jg8_B | PSEKN |
|||
402 | A | G | e | 31.2 | 5jg8_B | AGDKCNPR |
|||
403 | G | G | e | 41.7 | 5jg8_B | GKNASEHQ |
|||
404 | Q | H | b | 0.0 | 5jg8_B | QSTEHKLM |
|||
405 | L | H | b | 0.0 | 5jg8_B | LFMS |
|||
406 | Q | H | e | 36.7 | 5jg8_B | otherpoly | EQLDRASV |
||
407 | W | H | e | 23.5 | 5jg8_B | W |
|||
408 | L | H | b | 0.0 | 5jg8_B | LFMIV |
|||
409 | V | H | b | 0.7 | 5jg8_B | GEVIKNR |
|||
410 | G | H | e | 52.4 | 5jg8_B | NEDIYVQSGKF |
|||
411 | E | H | b | 18.1 | 5jg8_B | TQVE |
|||
412 | L | H | b | 0.6 | 5jg8_B | L |
|||
413 | Q | H | b | 7.1 | 5jg8_B | QENDIAFHKST |
|||
414 | A | H | e | 27.7 | 5jg8_B | EANDISQ |
|||
415 | A | H | b | 0.9 | 5jg8_B | ASMLYFI |
A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1451199 [MIM:607616] | ||
416 | E | H | b | 18.1 | 5jg8_B | RESQKL |
|||
417 | D | H | e | 72.2 | 5jg8_B | QDNLEKSARW |
|||
418 | R | H | e | 50.6 | 5jg8_B | RNAKVDI |
|||
419 | G | T | e | 73.8 | 5jg8_B | GKN |
|||
420 | D | b | 5.6 | 5jg8_B | EMDN |
||||
421 | K | E | e | 25.9 | 5jg8_B | KQMSLR |
|||
422 | V | E | b | 0.7 | 5jg8_B | VA |
|||
423 | H | E | b | 0.5 | 5jg8_B | WYHIL |
H->Y:(35.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1200741 [MIM:607616];H->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7674920 [MIM:257200] | ||
424 | I | E | b | 0.6 | 5jg8_B | ILV |
|||
425 | I | E | b | 1.2 | 5jg8_B | ISVLMT |
|||
426 | G | E | b | 0.0 | 5jg8_B | GAS |
G->S:(5.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200] | ||
427 | H | S | b | 0.0 | 5jg8_B | compound PC metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | H->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7947276 [MIM:607616] |
428 | I | S | b | 2.9 | 5jg8_B | VI |
|||
429 | P | b | 0.0 | 5jg8_B | PF |
||||
430 | P | T | b | 0.0 | 5jg8_B | PVDK |
|||
431 | G | T | e | 20.2 | 5jg8_B | GANSDK |
|||
432 | H | S | e | 44.5 | 5jg8_B | precipitant | YEHSFQRADKN |
||
433 | C | S | b | 0.0 | 5jg8_B | CFLNIMASTWY |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | C->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7795285 [MIM:607616] | |
434 | L | b | 12.9 | 5jg8_B | LYERQKTADIP |
L->P:(3.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |||
435 | K | S | e | 44.3 | 5jg8_B | compound NAG | KDEGSQNR |
||
436 | S | H | b | 10.2 | 5jg8_B | compound NAG | SGYTLKND |
||
437 | W | H | b | 1.2 | 5jg8_B | WYCFDALHQS |
W->C:(13.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
438 | S | H | b | 0.0 | 5jg8_B | SNAYDCVK |
S->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs2676070 [MIM:607616] | ||
439 | W | H | e | 35.1 | 5jg8_B | WEFLSATDQIY |
|||
440 | N | H | b | 3.6 | 5jg8_B | NKQSMRDEWTAGL |
|||
441 | Y | H | b | 0.0 | 5jg8_B | YLFKTCAGS |
|||
442 | Y | H | b | 0.0 | 5jg8_B | YFLTEGHAIVS |
|||
443 | R | H | e | 25.3 | 5jg8_B | DKRNSQELAGIPTV |
|||
444 | I | H | b | 0.6 | 5jg8_B | ILVKSWADEGNPQRT |
|||
445 | V | H | b | 2.0 | 5jg8_B | VFLIMTA |
|||
446 | A | H | b | 3.6 | 5jg8_B | RQSHNTAYGKLE |
|||
447 | R | H | b | 9.5 | 5jg8_B | REQKD |
|||
448 | Y | T | b | 0.9 | 5jg8_B | YFH |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7471433 [MIM:257200] | ||
449 | E | T | b | 7.5 | 5jg8_B | RSEQHA |
|||
450 | N | T | e | 30.9 | 5jg8_B | DNSRT |
|||
451 | T | T | b | 6.5 | 5jg8_B | TVI |
|||
452 | L | E | b | 6.7 | 5jg8_B | IVL |
L->P:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
453 | A | E | b | 12.5 | 5jg8_B | AIVTEL |
A->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
454 | A | E | b | 3.6 | 5jg8_B | GAFQS |
A->V:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1402734 [MIM:607616] | ||
455 | Q | E | b | 0.0 | 5jg8_B | QGHSM |
|||
456 | F | E | b | 0.0 | 5jg8_B | FLVI |
|||
457 | F | E | b | 0.0 | 5jg8_B | YF |
|||
458 | G | E | b | 0.0 | 5jg8_B | G |
G->D:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
459 | H | E | b | 18.8 | 5jg8_B | compound PC metal ZN precipitant | H |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | |
460 | T | E | b | 15.6 | 5jg8_B | precipitant | MTHIDE |
||
461 | H | E | b | 8.9 | 5jg8_B | compound PC metal ZN precipitant | HN |
BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" | |
462 | V | S | b | 13.3 | 5jg8_B | IRVTYMLS |
|||
463 | D | b | 5.6 | 5jg8_B | DEN |
||||
464 | E | E | b | 6.5 | 5jg8_B | HESQKTY |
|||
465 | F | E | b | 2.9 | 5jg8_B | FIL |
F->S:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1319643 [MIM:257200] | ||
466 | E | E | b | 2.5 | 5jg8_B | MSREVTYALDFGIKNPQ |
|||
467 | V | E | b | 0.0 | 5jg8_B | VMFIL |
|||
468 | F | E | b | 0.0 | 5jg8_B | FLYQIM |
|||
469 | Y | E | b | 3.5 | 5jg8_B | YSFHLI |
Y->S:(21.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200] | ||
470 | D | b | 5.6 | 5jg8_B | DEA |
||||
471 | E | T | e | 40.2 | 5jg8_B | DEKVNF |
|||
472 | E | T | e | 75.4 | 5jg8_B | DNPAEKGILQRSTV |
|||
473 | T | T | e | 52.6 | 5jg8_B | TNSKEVPYDGALFIQR |
|||
474 | L | S | b | 18.5 | 5jg8_B | LKSDHNPTVAGEFIQRY |
|||
475 | S | e | 60.9 | 5jg8_B | SGTERHALDFIKNPQVY |
||||
476 | R | S | e | 37.2 | 5jg8_B | RNKSITEADFGLPQV |
R->W:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1828129 [MIM:607616];R->Q:(1.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs7635669 [MIM:607616] | ||
477 | P | E | b | 13.2 | 5jg8_B | PDNAEGKLSTV |
P->L:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs7535088 [MIM:257200];P->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7535088 [MIM:607616] | ||
478 | L | E | b | 9.0 | 5jg8_B | ITLHVFMAEGKS |
|||
479 | A | E | b | 6.2 | 5jg8_B | NSGYAHEKLTV |
|||
480 | V | E | b | 6.7 | 5jg8_B | VFSIMAEGKLT |
|||
481 | A | E | b | 0.0 | 5jg8_B | MGVNALIEKST |
|||
482 | F | E | b | 2.9 | 5jg8_B | FYQWAEGKLSTV |
F->L:(1.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
483 | L | E | b | 0.0 | 5jg8_B | LIVASTEGK |
|||
484 | A | E | b | 0.0 | 5jg8_B | ASTGVEKL |
A->E:(1.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs2676070 [MIM:257200] | ||
485 | P | E | b | 1.6 | 5jg8_B | PGS |
|||
486 | S | b | 0.0 | 5jg8_B | SAGLV |
||||
487 | A | S | b | 0.0 | 5jg8_B | VALDI |
A->V:(43.0 %):LB/B - dbSNP:rs1416412 | ||
488 | T | S | b | 0.0 | 5jg8_B | TD |
T->A:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
489 | T | b | 0.0 | 5jg8_B | TPEN |
||||
490 | Y | T | e | 22.2 | 5jg8_B | precipitant | YVSFLWR |
Y->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3981234 [MIM:607616] | |
491 | I | T | e | 56.7 | 5jg8_B | precipitant | IYQKPSDEML |
||
492 | G | T | e | 20.2 | 5jg8_B | GDNFWYHST |
G->S:(4.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1448733 [MIM:607616] | ||
493 | L | b | 4.5 | 5jg8_B | VIQLNHY |
||||
494 | N | b | 2.4 | 5jg8_B | NKEF |
N->I:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
495 | P | b | 0.0 | 5jg8_B | P |
||||
496 | G | E | b | 0.0 | 5jg8_B | GAKTS |
G->S:(6.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | ||
497 | Y | E | b | 1.7 | 5jg8_B | YFIVL |
|||
498 | R | E | b | 0.4 | 5jg8_B | RVK |
R->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200];R->C:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7699047 [MIM:607616];R->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | ||
499 | V | E | b | 0.0 | 5jg8_B | ILVKQ |
|||
500 | Y | E | b | 0.0 | 5jg8_B | YFS |
|||
501 | Q | E | b | 12.2 | 5jg8_B | QETL |
|||
502 | I | E | b | 0.6 | 5jg8_B | IFVLAEGSDKNPQRTCHMWY |
|||
503 | D | E | b | 1.9 | 5jg8_B | DLAEGSVFIKNPQRTCHMWY |
|||
504 | G | b | 1.2 | 5jg8_B | GASLEVDIKNPRTFQYCHMW |
||||
505 | N | S | e | 45.5 | 5jg8_B | compound NAG otherpoly precipitant | NQGVLAESDIKPRTFYCHMW |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." | |
506 | Y | S | e | 30.0 | 5jg8_B | YHAGLDEFIKNPQRSTV |
|||
507 | S | T | e | 89.1 | 5jg8_B | DKAPSENFGILQRTV |
S->G:(1.0 %):LB/B - | ||
508 | G | T | e | 94.0 | 5jg8_B | GPYRSILADEFKNQTV |
G->R:(11.0 %):LB/B - dbSNP:rs1050239 | ||
509 | S | b | 4.7 | 5jg8_B | SAQGRNTLDEFIKPVY |
||||
510 | S | b | 6.2 | 5jg8_B | TSDKAEGILNPRV |
MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" MOD_RES /note="Phosphoserine; by PKC/PRKCD" MUTAGEN /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" | S->F:(0.0 %):LB/B - dbSNP:rs2006526 | ||
511 | H | b | 2.6 | 5jg8_B | YFHKLNGADEIPRSTV |
||||
512 | V | b | 14.7 | 5jg8_B | KNQTVAYSDEGILPR |
||||
513 | V | E | b | 4.0 | 5jg8_B | LVIADEGKNPRST |
|||
514 | L | E | b | 19.1 | 5jg8_B | LKVTIMADEGNPRS |
|||
515 | D | E | b | 15.4 | 5jg8_B | DEN |
|||
516 | H | E | b | 1.0 | 5jg8_B | YMLHIAFS |
H->Q:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
517 | E | E | b | 3.0 | 5jg8_B | ETVYLPKS |
E->V:(14.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1427870 [MIM:607616] | ||
518 | T | E | b | 0.0 | 5jg8_B | TQAE |
|||
519 | Y | E | b | 6.5 | 5jg8_B | YFW |
Y->C:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3718372 [MIM:257200] | ||
520 | I | E | b | 1.2 | 5jg8_B | otherpoly | FYHIPW |
I->L:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
521 | L | E | b | 0.0 | 5jg8_B | LATESMF |
|||
522 | N | e | 23.0 | 5jg8_B | compound NAG otherpoly | ND |
CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." CARBOHYD /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" MUTAGEN /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." | N->S:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
523 | L | H | b | 0.0 | 5jg8_B | LVI |
|||
524 | T | H | e | 57.1 | 5jg8_B | compound NAG otherpoly | TSYER |
||
525 | Q | H | e | 62.2 | 5jg8_B | compound NAG otherpoly | EQDIKS |
Q->H:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |
526 | A | H | b | 2.7 | 5jg8_B | ANES |
|||
527 | N | T | e | 24.2 | 5jg8_B | NFIT |
|||
528 | I | S | e | 56.7 | 5jg8_B | homo | LAEIMVGS |
||
529 | P | T | e | 96.1 | 5jg8_B | homo | KNQTEPSA |
||
530 | G | T | e | 96.4 | 5jg8_B | GPDN |
|||
531 | A | e | 33.9 | 5jg8_B | TEKAHNG |
||||
532 | I | e | 83.0 | 5jg8_B | TVIMLKNEAGSCDFHPQRY |
||||
533 | P | e | 20.2 | 5jg8_B | PSGVDLAEFIKNQRTY |
||||
534 | H | e | 67.0 | 5jg8_B | NRKVEHTISAL |
||||
535 | W | E | b | 7.2 | 5jg8_B | WYF |
W->R:(0.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1554935 [MIM:257200];W->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | ||
536 | Q | E | e | 30.6 | 5jg8_B | compound NAG otherpoly | EQTKSVLY |
||
537 | L | e | 31.5 | 5jg8_B | LEKVQR |
||||
538 | L | e | 25.3 | 5jg8_B | ELTS |
||||
539 | Y | b | 4.8 | 5jg8_B | Y |
Y->H:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | |||
540 | R | B | e | 36.4 | 5jg8_B | RDSQNITV |
|||
541 | A | H | b | 0.0 | 5jg8_B | ALTF |
|||
542 | R | H | e | 41.1 | 5jg8_B | TRVKN |
|||
543 | E | H | e | 78.9 | 5jg8_B | EQSMN |
|||
544 | T | H | e | 31.8 | 5jg8_B | ATIEFLH |
|||
545 | Y | H | b | 3.5 | 5jg8_B | YFH |
|||
546 | G | T | e | 65.5 | 5jg8_B | GNDQS |
|||
547 | L | b | 2.8 | 5jg8_B | IMLVT |
||||
548 | P | S | e | 69.0 | 5jg8_B | PDAFKQE |
|||
549 | N | e | 32.1 | 5jg8_B | DNG |
N->K:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | |||
550 | T | S | b | 1.9 | 5jg8_B | LAQFT |
|||
551 | L | S | e | 26.4 | 5jg8_B | SQYILTM |
L->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
552 | P | H | b | 19.4 | 5jg8_B | PGAV |
|||
553 | T | H | e | 48.7 | 5jg8_B | TIKLVQHSAE |
|||
554 | A | H | b | 6.2 | 5jg8_B | SGAE |
|||
555 | W | H | b | 1.2 | 5jg8_B | WLMY |
|||
556 | H | H | b | 17.8 | 5jg8_B | HNYTDS |
|||
557 | N | H | e | 50.9 | 5jg8_B | KDTSGNEQLA |
|||
558 | L | H | b | 0.0 | 5jg8_B | LVAM |
|||
559 | V | H | b | 0.7 | 5jg8_B | IAVLMYS |
|||
560 | Y | H | e | 23.9 | 5jg8_B | QEDYKLNT |
|||
561 | R | H | e | 37.9 | 5jg8_B | RQKLN |
|||
562 | M | H | b | 1.4 | 5jg8_B | MILF |
|||
563 | R | H | e | 30.0 | 5jg8_B | precipitant | AKRVTFQNW |
||
564 | G | H | e | 76.2 | 5jg8_B | precipitant | TSGKQDI |
||
565 | D | e | 42.0 | 5jg8_B | precipitant | DSNEV |
D->Y:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
566 | M | H | e | 30.9 | 5jg8_B | precipitant | STNEDPQM |
||
567 | Q | H | e | 77.0 | 5jg8_B | precipitant | SKTQH |
||
568 | L | H | b | 14.6 | 5jg8_B | LQIMKT |
|||
569 | F | H | b | 0.0 | 5jg8_B | FLR |
|||
570 | Q | H | e | 37.2 | 5jg8_B | NQLEIR |
|||
571 | T | H | e | 33.1 | 5jg8_B | KDTRNS |
|||
572 | F | H | b | 1.9 | 5jg8_B | YF |
F->L:(0.0 %):LP/P Niemann-Pick disease A (NPDA) [MIM:257200] | ||
573 | W | H | b | 13.1 | 5jg8_B | YHWVAGLSDEFIKNPQRT |
|||
574 | F | H | e | 45.5 | 5jg8_B | compound NAG otherpoly | FYEHQRVKN |
||
575 | L | H | b | 3.9 | 5jg8_B | YLVNEHAGST |
|||
576 | Y | H | b | 17.8 | 5jg8_B | YFAHN |
|||
577 | H | T | b | 11.5 | 5jg8_B | NFYHL |
H->D:(0.0 %):US Niemann-Pick disease B (NPDB) [MIM:607616] | ||
578 | K | T | b | 0.0 | 5jg8_B | SRVK |
K->N:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs7473424 [MIM:607616] | ||
579 | G | T | e | 20.2 | 5jg8_B | compound NAG otherpoly | SVNGRA |
G->S:(29.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs1200741 [MIM:257200] | |
580 | H | e | 34.0 | 5jg8_B | homo | YSHF |
|||
581 | P | e | 36.4 | 5jg8_B | homo | PDYS |
|||
582 | P | e | 51.9 | 5jg8_B | homo precipitant | PSNGIE |
|||
583 | S | S | e | 102.3 | 5jg8_B | homo precipitant | SKQRTNAH |
||
584 | E | S | e | 79.4 | 5jg8_B | precipitant | EAKVLGST |
||
585 | P | e | 84.5 | 5jg8_B | precipitant | PTGSVILADEFKNQRY |
|||
586 | C | b | 18.7 | 5jg8_B | precipitant | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
587 | G | e | 21.4 | 5jg8_B | precipitant | DGNTYEQ |
|||
588 | T | H | e | 55.2 | 5jg8_B | precipitant | QTSEDGK |
||
589 | P | H | e | 79.8 | 5jg8_B | precipitant | ASKPTIQHR |
||
590 | C | H | e | 21.3 | 5jg8_B | precipitant | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | |
591 | R | H | b | 8.7 | 5jg8_B | RKQS |
|||
592 | L | H | e | 27.5 | 5jg8_B | LTMIKNYA |
|||
593 | A | H | e | 58.0 | 5jg8_B | QAFGIKLDTE |
|||
594 | T | H | b | 8.4 | 5jg8_B | QYTHLWF |
|||
595 | L | H | b | 0.0 | 5jg8_B | ILVM |
|||
596 | C | H | e | 26.7 | 5jg8_B | C |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
597 | A | H | e | 36.6 | 5jg8_B | ADNSK |
|||
598 | Q | H | b | 1.0 | 5jg8_B | IMQLN |
Q->R:(0.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs1554935 [MIM:607616] | ||
599 | L | H | b | 0.0 | 5jg8_B | LKMRQ |
L->F:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs1385319 [MIM:607616] | ||
600 | S | b | 19.5 | 5jg8_B | SNMKHQD |
||||
601 | A | b | 0.9 | 5jg8_B | AGLVS |
||||
602 | R | S | b | 7.9 | 5jg8_B | RDAHM |
R->H:(13.0 %):LP/P Niemann-Pick disease A (NPDA) dbSNP:rs3701290 [MIM:257200];R->H:(13.0 %):LP/P Niemann-Pick disease B (NPDB) dbSNP:rs3701290 [MIM:607616];R->P:(0.0 %):LP/P Niemann-Pick disease B (NPDB) [MIM:607616] | ||
603 | A | T | b | 5.4 | 5jg8_B | SAHYFIVNL |
|||
604 | D | T | e | 49.4 | 5jg8_B | DNYILV |
|||
605 | S | b | 8.6 | 5jg8_B | SDKAT |
S->G:(0.0 %):LB/B - | |||
606 | P | G | e | 83.7 | 5jg8_B | YPTED |
|||
607 | A | G | e | 48.2 | 5jg8_B | ATLSYCE |
|||
608 | L | G | b | 5.1 | 5jg8_B | LDTYFE |
|||
609 | C | G | b | 12.7 | 5jg8_B | CK |
DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" DISULFID ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" | ||
610 | R | G | e | 54.5 | 5jg8_B | RDILQAEGKNPSTV |
R->C:(0.0 %):US Niemann-Pick disease B (NPDB) dbSNP:rs3759151 [MIM:607616] | ||
611 | H | G | e | 49.7 | 5jg8_B | HADEGIKLNPRSTV |
|||
612 | L | G | b | 1.1 | 5jg8_B | L |
|||
613 | M | e | 84.5 | 5jg8_B | MYV |
||||
614 | P | - | - | - | - | PA |
|||
615 | D | - | - | - | - | DSN |
|||
616 | G | - | - | - | - | GA |
|||
617 | S | - | - | - | - | ST |
|||
618 | L | - | - | - | - | LT |
|||
619 | P | - | - | - | - | P |
|||
620 | E | - | - | - | - | DVE |
|||
621 | A | - | - | - | - | APV |
|||
622 | Q | - | - | - | - | QN |
|||
623 | S | - | - | - | - | SR |
|||
624 | L | - | - | - | - | L |
|||
625 | W | - | - | - | - | W |
|||
626 | P | - | - | - | - | SP |
|||
627 | R | - | - | - | - | RM |
|||
628 | P | - | - | - | - | P |
|||
629 | L | - | - | - | - | L |
|||
630 | F | - | - | - | - | LF |
|||
631 | C | - | - | - | - | C |