Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
24220 | 63 | 6 | P59634(NS6_SARS) | RecName: Full=ORF6 protein; Short=ORF6;AltName: Full=Accessory protein 6;AltName: Full=Non-structural protein 6; Short=ns6;AltName: Full=Protein X3; |
QUERYSEQ |
MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
1 | M | - | - | - | - | M |
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2 | F | - | - | - | - | F |
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3 | H | - | - | - | - | H |
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4 | L | - | - | - | - | L |
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5 | V | - | - | - | - | V |
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6 | D | - | - | - | - | D |
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7 | F | - | - | - | - | F |
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8 | Q | - | - | - | - | Q |
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9 | V | - | - | - | - | V |
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10 | T | - | - | - | - | T |
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11 | I | - | - | - | - | I |
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12 | A | - | - | - | - | A |
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13 | E | - | - | - | - | E |
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14 | I | - | - | - | - | I |
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15 | L | - | - | - | - | L |
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16 | I | - | - | - | - | IL |
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17 | I | - | - | - | - | I |
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18 | I | - | - | - | - | I |
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19 | M | - | - | - | - | M |
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20 | R | - | - | - | - | RK |
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21 | T | - | - | - | - | T |
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22 | F | - | - | - | - | F |
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23 | R | - | - | - | - | RK |
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24 | I | - | - | - | - | VI |
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25 | A | - | - | - | - | AS |
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26 | I | - | - | - | - | I |
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27 | W | - | - | - | - | W |
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28 | N | - | - | - | - | N |
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29 | L | - | - | - | - | L |
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30 | D | - | - | - | - | D |
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31 | V | - | - | - | - | YIV |
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32 | I | - | - | - | - | IL |
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33 | I | - | - | - | - | I |
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34 | S | - | - | - | - | SN |
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35 | S | - | - | - | - | SL |
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36 | I | - | - | - | - | I |
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37 | V | - | - | - | - | VI |
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38 | R | - | - | - | - | RK |
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39 | Q | - | - | - | - | QN |
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40 | L | - | - | - | - | L |
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41 | F | - | - | - | - | FS |
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42 | K | - | - | - | - | K |
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43 | P | - | - | - | - | PS |
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44 | L | - | - | - | - | L |
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45 | T | - | - | - | - | T |
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46 | K | - | - | - | - | KE |
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47 | K | - | - | - | - | KN |
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48 | N | - | - | - | - | NK |
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49 | Y | - | - | - | - | Y |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | ||
50 | S | e | 131.2 | 7vpg_I | S |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | |||
51 | E | e | 85.4 | 7vpg_I | EQ |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | |||
52 | L | e | 119.7 | 7f90_B | hetero RAE1L_HUMAN | L |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | ||
53 | D | e | 88.9 | 7f90_B | hetero RAE1L_HUMAN | D |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." | ||
54 | D | S | e | 77.2 | 7f90_B | hetero RAE1L_HUMAN | DE |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | |
55 | E | e | 95.5 | 7f90_B | hetero RAE1L_HUMAN | E |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | ||
56 | E | e | 72.4 | 7f90_B | hetero RAE1L_HUMAN | EQ |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | ||
57 | P | e | 95.3 | 7f90_B | hetero RAE1L_HUMAN | P |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
58 | M | e | 75.8 | 7f90_B | hetero RAE1L_HUMAN | M |
MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import" | ||
59 | E | e | 95.0 | 7f90_B | hetero RAE1L_HUMAN NUP98_HUMAN | E |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
60 | L | e | 74.2 | 7f90_B | hetero RAE1L_HUMAN | LI |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
61 | D | e | 91.4 | 7f90_B | hetero RAE1L_HUMAN | D |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
62 | Y | e | 84.3 | 7f90_B | hetero RAE1L_HUMAN | Y |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
63 | P | e | 124.0 | 7f90_B | P |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" |