Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
20585 | 425 | 86 | P84022(SMAD3_HUMAN) | RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3; |
QUERYSEQ |
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEF PPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS |
All | 613795 Loeys-Dietz syndrome 3 (LDS3) | LB/B (likely benign or benign) | US (uncertain significance) | ||
Number of sites | 425 | 5 | 1 | 1 | |
Buired or Exposed | Buried | 40.9 (%) [137] | 60.0 (%) [3] | 100.0 (%) [1] | |
Exposed | 59.1 (%) [198] | 40.0 (%) [2] | 0.0 (%) [0] | ||
Ave relacc | 33.0 % | 20.3 % | 0.0 % | 3.9 % | |
SD relacc | 29.41 % | 23.52 % | 0.00 % | 0.00 % | |
Contact Mol | hetero | 29.2 (%) [124] | 60.0 (%) [3] | 0.0 (%) [0] | 0.0 (%) [0] |
nucleotide | 4.2 (%) [18] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 3.8 (%) [16] | 40.0 (%) [2] | 0.0 (%) [0] | 0.0 (%) [0] | |
metal | 5.2 (%) [22] | 20.0 (%) [1] | 0.0 (%) [0] | 0.0 (%) [0] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 38.4 (%) [163] | 60.0 (%) [3] | 0.0 (%) [0] | 0.0 (%) [0] | |
precipitant | 22.8 (%) [97] | 20.0 (%) [1] | 0.0 (%) [0] | 0.0 (%) [0] | |
Number of variants | 7 | 5 | 1 | 1 | |
N_Freq(AAvariant)==0 % | 60.0 % [3] | 0.0 % [0] | 100.0 % [1] | ||
N_Freq(AAvariant)>0 % | 40.0 % [2] | 100.0 % [1] | 0.0 % [0] | ||
Ave Freq(AAvariant) | 3.4 % | 13.0 % | 0.0 % | ||
SD Freq(AAvariant) | 4.18 % | 0.00 % | 0.00 % |
5 sites | 112,239,261,279,287 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
112 | A | b | 1.8 | 1ozj_C | metal CL | APYFCST |
DOMAIN /note="MH1" DOMAIN /note="MH1" | A->V:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795] | |
239 | E | E | b | 1.0 | 1mk2_A | E |
DOMAIN /note="MH2" DOMAIN /note="MH2" | E->K:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795] | |
261 | T | S | e | 64.3 | 1mk2_A | hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN homo | TYIMV |
DOMAIN /note="MH2" DOMAIN /note="MH2" | T->I:(9.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795] |
279 | R | e | 24.1 | 1mk2_A | hetero SMAD4_HUMAN compound TAR homo precipitant | RK |
REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" | R->K:(8.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795] | |
287 | R | H | b | 10.3 | 1mk2_A | hetero SMAD4_HUMAN SMAD3_HUMAN SMAD2_HUMAN compound TAR homo | R |
REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" REGION /note="Sufficient for interaction with XPO4" DOMAIN /note="MH2" | R->W:(0.0 %):LP/P Loeys-Dietz syndrome 3 (LDS3) dbSNP:rs3879068 [MIM:613795] |
1 sites | 170 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
170 | I | - | - | - | - | IFVLSADEGKNPQRTY |
REGION /note="Disordered" REGION /note="Linker" REGION /note="Disordered" REGION /note="Linker" | I->V:(13.0 %):LB/B - dbSNP:rs3587446 |
1 sites | 393 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
393 | P | S | b | 3.9 | 1mk2_A | P |
DOMAIN /note="MH2" DOMAIN /note="MH2" | P->L:(0.0 %):US A colorectal cancer sample |