Contact Molecules for Homologous Proteins | ||||
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seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100] | ![]() [show] [download] [help] |
PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
1956853 | 63 | 6 | P59634(NS6_SARS) | RecName: Full=ORF6 protein; Short=ORF6;AltName: Full=Accessory protein 6;AltName: Full=Non-structural protein 6; Short=ns6;AltName: Full=Protein X3; |
QUERYSEQ |
MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
![]() | M | - | - | - | - | M |
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![]() | F | - | - | - | - | F |
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![]() | H | - | - | - | - | H |
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![]() | L | - | - | - | - | L |
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![]() | V | - | - | - | - | V |
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![]() | D | - | - | - | - | D |
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![]() | F | - | - | - | - | F |
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![]() | Q | - | - | - | - | Q |
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![]() | V | - | - | - | - | V |
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![]() | T | - | - | - | - | T |
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![]() | I | - | - | - | - | I |
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![]() | A | - | - | - | - | A |
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![]() | E | - | - | - | - | E |
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![]() | I | - | - | - | - | I |
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![]() | L | - | - | - | - | L |
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![]() | I | - | - | - | - | IL |
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![]() | I | - | - | - | - | I |
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![]() | I | - | - | - | - | I |
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![]() | M | - | - | - | - | M |
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![]() | R | - | - | - | - | RK |
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![]() | T | - | - | - | - | T |
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![]() | F | - | - | - | - | F |
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![]() | R | - | - | - | - | RK |
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![]() | I | - | - | - | - | VI |
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![]() | A | - | - | - | - | AS |
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![]() | I | - | - | - | - | I |
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![]() | W | - | - | - | - | W |
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![]() | N | - | - | - | - | N |
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![]() | L | - | - | - | - | L |
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![]() | D | - | - | - | - | D |
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![]() | V | - | - | - | - | YIV |
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![]() | I | - | - | - | - | IL |
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![]() | I | - | - | - | - | I |
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![]() | S | - | - | - | - | SN |
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![]() | S | - | - | - | - | SL |
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![]() | I | - | - | - | - | I |
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![]() | V | - | - | - | - | VI |
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![]() | R | - | - | - | - | RK |
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![]() | Q | - | - | - | - | QN |
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![]() | L | - | - | - | - | L |
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![]() | F | - | - | - | - | FS |
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![]() | K | - | - | - | - | K |
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![]() | P | - | - | - | - | PS |
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![]() | L | - | - | - | - | L |
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![]() | T | - | - | - | - | T |
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![]() | K | - | - | - | - | KE |
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![]() | K | - | - | - | - | KN |
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![]() | N | - | - | - | - | NK |
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![]() | Y | - | - | - | - | Y |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | ||
![]() | S | e | 131.2 | ![]() |
S |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | |||
![]() | E | e | 85.4 | ![]() |
EQ |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | |||
![]() | L | e | 91.0 | ![]() |
hetero RAE1L_HUMAN | L |
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." | ||
![]() | D | e | 97.5 | ![]() |
hetero RAE1L_HUMAN | D |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." | ||
![]() | D | e | 89.5 | ![]() |
hetero RAE1L_HUMAN | DE |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | ||
![]() | E | e | 98.0 | ![]() |
hetero RAE1L_HUMAN | E |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | ||
![]() | E | e | 82.9 | ![]() |
hetero RAE1L_HUMAN | EQ |
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" | ||
![]() | P | e | 90.7 | ![]() |
hetero RAE1L_HUMAN | P |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
![]() | M | e | 80.2 | ![]() |
hetero RAE1L_HUMAN | M |
MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import" | ||
![]() | E | e | 96.5 | ![]() |
hetero RAE1L_HUMAN NUP98_HUMAN | E |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
![]() | L | e | 72.5 | ![]() |
hetero RAE1L_HUMAN | LI |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
![]() | D | e | 90.7 | ![]() |
hetero RAE1L_HUMAN | D |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
![]() | Y | e | 118.3 | ![]() |
hetero RAE1L_HUMAN | Y |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" | ||
![]() | P | e | 124.0 | ![]() |
P |
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import" |