Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
30181 425 13 P84022(SMAD3_HUMAN) RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3;
QUERYSEQ 
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEF
PPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P84022(SMAD3_HUMAN)]

425
region name description
2-425 CHAIN /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856"
10-136 DOMAIN /note="MH1"
232-425 DOMAIN /note="MH2"
137-231 REGION /note="Linker"
165-208 REGION /note="Disordered"
271-324 REGION /note="Sufficient for interaction with XPO4"
64-64 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
109-109 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
121-121 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
126-126 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
1-425 DISORDER predicted by DISOPRED

MONOMER
425
pdb_id a1 identity[%]2 description
1mk2 A 100.0 SMAD3_HUMAN SMAD 3
1u7f A 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1u7f C 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1mjs A 100.0 SMAD3_HUMAN SMAD 3
1ozj C 100.0 SMAD3_HUMAN SMAD 3
5odg A 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6 B 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg B 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6 A 100.0 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1ozj D 100.0 SMAD3_HUMAN SMAD 3
1mhd D 100.0 SMAD3_HUMAN SMAD3
1mhd C 100.0 SMAD3_HUMAN SMAD3 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2 B ZFYV9_HUMAN Madh-interacting protein[38 aa] A 100.0
/100.0		 31
/31		 SMAD3_HUMAN SMAD 3
1mk2 B ZFYV9_HUMAN Madh-interacting protein[38 aa] A 100.0
/100.0		 31
/31		 SMAD3_HUMAN SMAD 3
1u7f B SMAD4_HUMAN Mothers against decapentaplegic homolog 4[193 aa] A 96.3
/100.0		 27
/28		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1u7f B SMAD4_HUMAN Mothers against decapentaplegic homolog 4[193 aa] C 100.0
/100.0		 20
/20		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc B THIO_ECOLI FOXH1_HUMAN Thioredoxin 1,Forkhead box protein H1[133 aa] A 100.0
/100.0		 26
/26		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc B THIO_ECOLI FOXH1_HUMAN Thioredoxin 1,Forkhead box protein H1[133 aa] A 100.0
/100.0		 26
/26		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc B THIO_ECOLI FOXH1_HUMAN Thioredoxin 1,Forkhead box protein H1[133 aa] A 100.0
/100.0		 26
/26		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
NUCLEOTIDE
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mhd A DNA C 100.0
/100.0		 9
/9		 SMAD3_HUMAN SMAD3
1mhd A DNA D 100.0
/100.0		 3
/3		 SMAD3_HUMAN SMAD3
1mhd B DNA C 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD3
1mhd B DNA D 100.0
/100.0		 7
/7		 SMAD3_HUMAN SMAD3
1ozj A Smad binding element C 100.0
/100.0		 10
/10		 SMAD3_HUMAN SMAD 3
1ozj A Smad binding element D 100.0
/100.0		 3
/3		 SMAD3_HUMAN SMAD 3
1ozj B Smad binding element C 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1ozj B Smad binding element D 100.0
/100.0		 9
/9		 SMAD3_HUMAN SMAD 3
5od6 C DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6 D DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. A 100.0
/100.0		 9
/9		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg C DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 8
/8		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg C DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 8
/8		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg C DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. B 100.0
/100.0		 3
/3		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg C DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. B 100.0
/100.0		 3
/3		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg D DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg D DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg D DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. B 100.0
/100.0		 11
/11		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg D DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. B 100.0
/100.0		 11
/11		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1ozj E ZN
ZINC ION[1 atoms] 		C 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
1ozj F ZN
ZINC ION[1 atoms] 		D 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
5od6 E ZN
ZINC ION[1 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6 F ZN
ZINC ION[1 atoms] 		B 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg E ZN
ZINC ION[1 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg E ZN
ZINC ION[1 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg G ZN
ZINC ION[1 atoms] 		B 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg G ZN
ZINC ION[1 atoms] 		B 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg F CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg F CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2 A SMAD3_HUMAN SMAD 3[197 aa] A 100.0
/100.0		 12
/12		 SMAD3_HUMAN SMAD 3
1mk2 A SMAD3_HUMAN SMAD 3[197 aa] A 100.0
/100.0		 12
/12		 SMAD3_HUMAN SMAD 3
1u7f C SMAD3_HUMAN Mothers against decapentaplegic homolog 3[196 aa] A 100.0
/100.0		 23
/23		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1u7f A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[198 aa] C 95.7
/100.0		 23
/24		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 17
/17		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 14
/14		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 14
/14		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 17
/17		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 17
/17		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 14
/14		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1ozj D SMAD3_HUMAN SMAD 3[124 aa] C 100.0
/100.0		 1
/1		 SMAD3_HUMAN SMAD 3
1ozj C SMAD3_HUMAN SMAD 3[126 aa] D 100.0
/100.0		 1
/1		 SMAD3_HUMAN SMAD 3
5od6 B SMAD3_HUMAN Mothers against decapentaplegic homolog 3[126 aa] A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6 A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[125 aa] B 100.0
/100.0		 8
/8		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2 C ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2 C ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2 D ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2 D ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 2
/2		 SMAD3_HUMAN SMAD 3
1mk2 D ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 2
/2		 SMAD3_HUMAN SMAD 3
1mk2 D ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2 E ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 3
/3		 SMAD3_HUMAN SMAD 3
1mk2 E ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 3
/3		 SMAD3_HUMAN SMAD 3
1mk2 F ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
1mk2 F ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.