Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
15368 | 468 | 15 | P08887(IL6RA_HUMAN) | RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor; |
QUERYSEQ |
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLV RKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA RDPRSPYDISNTDYFFPR |
468 |
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region | name | description |
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1-19 | SIGNAL | |
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20-468 | CHAIN | /note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895" |
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20-355 | CHAIN | /note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730" |
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20-365 | TOPO_DOM | /note="Extracellular" |
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366-386 | TRANSMEM | /note="Helical" |
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387-468 | TOPO_DOM | /note="Cytoplasmic" |
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26-112 | DOMAIN | /note="Ig-like C2-type" |
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113-217 | DOMAIN | /note="Fibronectin type-III 1" |
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218-316 | DOMAIN | /note="Fibronectin type-III 2" |
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303-328 | REGION | /note="Disordered" |
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421-468 | REGION | /note="Disordered" |
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311-328 | COMPBIAS | /note="Polar residues" |
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1-468 | DISORDER | predicted by DISOPRED |
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468 | |||||||
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pdb_id | a1 | identity[%]2 | description | |||
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A | 100.0 | IL6A_HUMAN IL-6 Receptor alpha chain | |||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
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468 | pdb_id | contact mol | homologue | ||||
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a3 | description | a4 | identity[%]5 | Ncon6 | description | |
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A | IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] | C | 100.0 /100.0 |
12 /12 |
IL6RA_HUMAN Interleukin-6 receptor alpha chain |
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A | IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] | C | 100.0 /100.0 |
8 /8 |
IL6RA_HUMAN Interleukin-6 receptor alpha chain |
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B | IL6_HUMAN Interleukin-6[163 aa] | C | 100.0 /100.0 |
15 /15 |
IL6RA_HUMAN Interleukin-6 receptor alpha chain |
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B | IL6_HUMAN INTERLEUKIN-6[160 aa] | C | 100.0 /99.0 |
18 /18 |
D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. |
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B | IL6_HUMAN Interleukin-6[169 aa] | A | 100.0 /100.0 |
12 /12 |
IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha |
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B | IL6_HUMAN Interleukin-6[157 aa] | C | 100.0 /100.0 |
11 /11 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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C | IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] | A | 100.0 /100.0 |
11 /11 |
IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha |
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F | IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] | A | 100.0 /100.0 |
6 /6 |
IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha |
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C | Light chain of Sarilumab Fab[212 aa] | A | 100.0 /100.0 |
6 /6 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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D | Heavy chain of Sarilumab Fab[207 aa] | A | 100.0 /100.0 |
12 /12 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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A | Heavy chain of Tocilizumab Fab[211 aa] | C | 100.0 /100.0 |
14 /14 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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D | IL6RA_HUMAN IL6R-D2 peptide[10 aa] | C | 100.0 /100.0 |
6 /6 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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A | IL6RB_MOUSE Interleukin-6 receptor subunit beta[584 aa] | C | 100.0 /100.0 |
14 /14 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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F | IL6RB_MOUSE Interleukin-6 receptor subunit beta[584 aa] | C | 100.0 /100.0 |
8 /8 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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A | Switch Ab Fab light chain[212 aa] | C | 100.0 /99.5 |
5 /5 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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B | Switch Ab Fab heavy chain[209 aa] | C | 100.0 /99.5 |
9 /9 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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E | VHH6[110 aa] | C | 100.0 /99.0 |
10 /10 |
D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. |
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A | IL6_HUMAN INTERLEUKIN-6[152 aa] | D | 100.0 /99.0 |
12 /12 |
D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. |
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F | VHH6[124 aa] | D | 100.0 /99.0 |
10 /10 |
D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
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468 | pdb_id | contact mol | homologue | ||||
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a3 | description | a4 | identity[%]5 | Ncon6 | description | |
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D |
NAG
|
A | 100.0 /100.0 |
5 /5 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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E |
NAG
|
A | 100.0 /100.0 |
3 /3 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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E |
NAG
|
A | 100.0 /100.0 |
3 /3 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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G |
NAG
|
C | 100.0 /99.0 |
3 /3 |
D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-.. |
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S |
NAG
|
A | 100.0 /100.0 |
3 /3 |
IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha |
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F |
NAG
|
A | 100.0 /100.0 |
3 /3 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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H |
CYS
|
A | 100.0 /100.0 |
5 /5 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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H |
ATP
|
C | 100.0 /99.5 |
1 /1 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
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468 | pdb_id | contact mol | homologue | ||||
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a3 | description | a4 | identity[%]5 | Ncon6 | description | |
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B | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. | A | 100.0 /100.0 |
9 /9 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. | A | 100.0 /100.0 |
5 /5 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. | A | 100.0 /100.0 |
1 /1 |
IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
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468 | pdb_id | contact mol | homologue | ||||
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a3 | description | a4 | identity[%]5 | Ncon6 | description | |
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A | IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] | A | 100.0 /100.0 |
11 /11 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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A | IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] | A | 100.0 /100.0 |
15 /15 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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B | IL6RA_HUMAN Interleukin-6 receptor subunit alpha[14 aa] | A | 100.0 /100.0 |
8 /8 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
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468 | pdb_id | contact mol | homologue | ||||
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a3 | description | a4 | identity[%]5 | Ncon6 | description | |
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F |
SO4
|
A | 100.0 /100.0 |
3 /3 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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G |
SO4
|
A | 100.0 /100.0 |
3 /3 |
IL6A_HUMAN IL-6 Receptor alpha chain |
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K |
SO4
|
C | 100.0 /99.5 |
3 /3 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
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L |
SO4
|
C | 100.0 /99.5 |
3 /3 |
IL6RA_HUMAN Interleukin-6 receptor subunit alpha |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |