Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2622207 | 358 | 30 | P13747(HLAE_HUMAN) | RecName: Full=HLA class I histocompatibility antigen, alpha chain E;AltName: Full=MHC class I antigen E;Contains: RecName: Full=Soluble HLA class I histocompatibility antigen, alpha chain E; Short=sHLA-E ;Flags: Precursor; |
QUERYSEQ |
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNED LRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL |
358 | region | name | description |
1-21 | SIGNAL | ||
22-358 | CHAIN | /note="HLA class I histocompatibility antigen, alpha chain E" /id="PRO_0000018882" | |
22-0 | CHAIN | /note="Soluble HLA class I histocompatibility antigen, alpha chain E" /id="PRO_0000445757" | |
22-305 | TOPO_DOM | /note="Extracellular" | |
306-329 | TRANSMEM | /note="Helical" | |
330-358 | TOPO_DOM | /note="Cytoplasmic" | |
206-294 | DOMAIN | /note="Ig-like C1-type" | |
22-111 | REGION | /note="Alpha-1" | |
112-203 | REGION | /note="Alpha-2" | |
204-295 | REGION | /note="Alpha-3" | |
296-305 | REGION | /note="Connecting peptide" | |
333-358 | REGION | /note="Disordered" | |
344-358 | COMPBIAS | /note="Polar residues" | |
28-28 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P4B" | |
84-84 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
87-87 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P4B" | |
98-98 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
98-98 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
105-105 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
105-105 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
164-164 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
164-164 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
167-167 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
167-167 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
177-177 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
180-180 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B" | |
180-180 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
192-192 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49" | |
192-192 | BINDING | /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen" | |
1-358 | DISORDER | predicted by DISOPRED |
MONOMER | |||||||
358 | |||||||
pdb_id | a1 | identity[%]2 | description | ||||
7p4b | C | 100.0 | HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E | ||||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
HETERO | |||||||
358 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6ggm[30] | B | B2MG_HUMAN Beta-2-microglobulin[100 aa] | A | 100.0 /100.0 |
33 /33 |
E2G051_HUMAN MHC class I antigen | |
7bh8[2] | D | B2MG_HUMAN Beta-2-microglobulin[98 aa] | A | 100.0 /100.0 |
1 /1 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
6ggm[2] | E | Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-.. | A | 100.0 /100.0 |
30 /30 |
E2G051_HUMAN MHC class I antigen | |
6gh1[7] | C | INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH][9 aa.. | A | 100.0 /100.0 |
22 /22 |
E2G051_HUMAN MHC class I antigen | |
6gh4[4] | I | ARG-GLN-PRO-ALA-LYS-ALA-PRO-LEU-LEU[9 aa] | A | 100.0 /100.0 |
26 /26 |
E2G051_HUMAN MHC class I antigen | |
6ghn[2] | E | ARG-LEU-PRO-ALA-LYS-ALA-PRO-LEU-PHE[9 aa] | A | 100.0 /100.0 |
23 /23 |
Q59EE1_HUMAN HLA class I histocompatibility antigen, E alpha ch.. | |
6gl1[4] | I | ARG-MET-TYR-SER-PRO-THR-SER-ILE-LEU[9 aa] | A | 100.0 /100.0 |
27 /27 |
E2G051_HUMAN MHC class I antigen | |
6zkw[1] | D | T-cell receptor alpha chain[188 aa] | A | 100.0 /100.0 |
7 /7 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
6zkw[1] | E | T-cell receptor beta chain[243 aa] | A | 100.0 /100.0 |
9 /9 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[2] | E | 3H4 Fab heavy chain[225 aa] | A | 100.0 /100.0 |
11 /11 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[2] | F | 3H4 Fab light chain[214 aa] | A | 100.0 /100.0 |
5 /5 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[2] | I | VL9 leader peptide[9 aa] | A | 100.0 /100.0 |
29 /29 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7ndq[1] | C | B6S6I4_9HIV1 Gag6V[9 aa] | A | 100.0 /100.0 |
25 /25 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7ndq[1] | D | TVA4_HUMAN A0A075B6U7_HUMAN TRAR1_HUMAN TCR Gag:02-alpha,TCR Gag:02-alpha,TCR Gag:02-alpha.. | A | 100.0 /100.0 |
9 /9 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7ndq[3] | E | TVB79_HUMAN TJB12_HUMAN K7N5M4_HUMAN T cell receptor beta variable 7-9,M1-specific T ce.. | A | 100.0 /100.0 |
8 /8 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[4] | I | PPSB_MYCTU Phenolphthiocerol/phthiocerol polyketide synthase .. | A | 100.0 /100.0 |
26 /26 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p4b[4] | I | ESXH_MYCTU ESAT-6-like protein EsxH[9 aa] | A | 100.0 /100.0 |
22 /22 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
8qfy[2] | D | T-cell receptor alpha chain[187 aa] | A | 100.0 /100.0 |
10 /10 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
METAL | |||||||
358 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6ggm[8] | G |
ZN
ZINC ION[1 atoms] |
A | 100.0 /100.0 |
2 /2 |
E2G051_HUMAN MHC class I antigen | |
6ggm[1] | H |
ZN
ZINC ION[1 atoms] |
A | 100.0 /100.0 |
2 /2 |
E2G051_HUMAN MHC class I antigen | |
6ggm[2] | I |
ZN
ZINC ION[1 atoms] |
A | 100.0 /100.0 |
2 /2 |
E2G051_HUMAN MHC class I antigen | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
HOMO | |||||||
358 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
7bh8[1] | C | HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | A | 100.0 /100.0 |
10 /10 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[1] | A | HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | C | 100.0 /100.0 |
6 /6 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
PRECIPITANT | |||||||
358 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6ggm[15] | J |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
3 /3 |
E2G051_HUMAN MHC class I antigen | |
6ggm[8] | K |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
3 /3 |
E2G051_HUMAN MHC class I antigen | |
6ggm[14] | P |
SO4
SULFATE ION[5 atoms] |
C | 100.0 /100.0 |
1 /1 |
E2G051_HUMAN MHC class I antigen | |
6gh1[8] | Q |
SO4
SULFATE ION[5 atoms] |
D | 100.0 /100.0 |
3 /3 |
E2G051_HUMAN MHC class I antigen | |
6ghn[1] | H |
SO4
SULFATE ION[5 atoms] |
C | 100.0 /100.0 |
2 /2 |
Q59EE1_HUMAN HLA class I histocompatibility antigen, E alpha ch.. | |
6gl1[1] | M |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
2 /2 |
E2G051_HUMAN MHC class I antigen | |
7p49[1] | O |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
3 /3 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[1] | R |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
1 /1 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[2] | S |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
3 /3 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[2] | DA |
SO4
SULFATE ION[5 atoms] |
C | 100.0 /100.0 |
1 /1 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p4b[1] | N |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /100.0 |
2 /2 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[7] | K |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /100.0 |
4 /4 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[4] | L |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /100.0 |
4 /4 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[1] | M |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /100.0 |
5 /5 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7bh8[4] | N |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /100.0 |
4 /4 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[1] | N |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /100.0 |
2 /2 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[1] | EA |
GOL
GLYCEROL[6 atoms] |
C | 100.0 /100.0 |
3 /3 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[1] | Z |
GOL
GLYCEROL[6 atoms] |
C | 100.0 /100.0 |
5 /5 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
7p49[1] | IA |
GOL
GLYCEROL[6 atoms] |
E | 100.0 /100.0 |
1 /1 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
8qfy[1] | K |
ACT
ACETATE ION[4 atoms] |
F | 100.0 /100.0 |
1 /1 |
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |