Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
2622207 358 30 P13747(HLAE_HUMAN) RecName: Full=HLA class I histocompatibility antigen, alpha chain E;AltName: Full=MHC class I antigen E;Contains: RecName: Full=Soluble HLA class I histocompatibility antigen, alpha chain E; Short=sHLA-E ;Flags: Precursor;
QUERYSEQ
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNED
LRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P13747(HLAE_HUMAN)]

358
region name description
1-21 SIGNAL
22-358 CHAIN /note="HLA class I histocompatibility antigen, alpha chain E" /id="PRO_0000018882"
22-0 CHAIN /note="Soluble HLA class I histocompatibility antigen, alpha chain E" /id="PRO_0000445757"
22-305 TOPO_DOM /note="Extracellular"
306-329 TRANSMEM /note="Helical"
330-358 TOPO_DOM /note="Cytoplasmic"
206-294 DOMAIN /note="Ig-like C1-type"
22-111 REGION /note="Alpha-1"
112-203 REGION /note="Alpha-2"
204-295 REGION /note="Alpha-3"
296-305 REGION /note="Connecting peptide"
333-358 REGION /note="Disordered"
344-358 COMPBIAS /note="Polar residues"
28-28 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P4B"
84-84 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
87-87 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P4B"
98-98 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
98-98 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
105-105 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
105-105 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
164-164 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
164-164 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
167-167 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
167-167 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
177-177 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
180-180 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B"
180-180 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
192-192 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="1" /ligand_note="pathogen-derived peptide antigen" ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49"
192-192 BINDING /ligand="a peptide antigen" /ligand_id="ChEBI:CHEBI:166823" /ligand_label="2" /ligand_note="self-peptide antigen"
1-358 DISORDER predicted by DISOPRED

MONOMER
358
pdb_id a1 identity[%]2 description
7p4b C 100.0 HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
358 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6ggm[30] B B2MG_HUMAN Beta-2-microglobulin[100 aa] A 100.0
/100.0
33
/33
E2G051_HUMAN MHC class I antigen
7bh8[2] D B2MG_HUMAN Beta-2-microglobulin[98 aa] A 100.0
/100.0
1
/1
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
6ggm[2] E Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-.. A 100.0
/100.0
30
/30
E2G051_HUMAN MHC class I antigen
6gh1[7] C INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH][9 aa.. A 100.0
/100.0
22
/22
E2G051_HUMAN MHC class I antigen
6gh4[4] I ARG-GLN-PRO-ALA-LYS-ALA-PRO-LEU-LEU[9 aa] A 100.0
/100.0
26
/26
E2G051_HUMAN MHC class I antigen
6ghn[2] E ARG-LEU-PRO-ALA-LYS-ALA-PRO-LEU-PHE[9 aa] A 100.0
/100.0
23
/23
Q59EE1_HUMAN HLA class I histocompatibility antigen, E alpha ch..
6gl1[4] I ARG-MET-TYR-SER-PRO-THR-SER-ILE-LEU[9 aa] A 100.0
/100.0
27
/27
E2G051_HUMAN MHC class I antigen
6zkw[1] D T-cell receptor alpha chain[188 aa] A 100.0
/100.0
7
/7
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
6zkw[1] E T-cell receptor beta chain[243 aa] A 100.0
/100.0
9
/9
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[2] E 3H4 Fab heavy chain[225 aa] A 100.0
/100.0
11
/11
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[2] F 3H4 Fab light chain[214 aa] A 100.0
/100.0
5
/5
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[2] I VL9 leader peptide[9 aa] A 100.0
/100.0
29
/29
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7ndq[1] C B6S6I4_9HIV1 Gag6V[9 aa] A 100.0
/100.0
25
/25
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7ndq[1] D TVA4_HUMAN A0A075B6U7_HUMAN TRAR1_HUMAN TCR Gag:02-alpha,TCR Gag:02-alpha,TCR Gag:02-alpha.. A 100.0
/100.0
9
/9
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7ndq[3] E TVB79_HUMAN TJB12_HUMAN K7N5M4_HUMAN T cell receptor beta variable 7-9,M1-specific T ce.. A 100.0
/100.0
8
/8
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[4] I PPSB_MYCTU Phenolphthiocerol/phthiocerol polyketide synthase .. A 100.0
/100.0
26
/26
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p4b[4] I ESXH_MYCTU ESAT-6-like protein EsxH[9 aa] A 100.0
/100.0
22
/22
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
8qfy[2] D T-cell receptor alpha chain[187 aa] A 100.0
/100.0
10
/10
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
358 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6ggm[8] G ZN
ZINC ION[1 atoms]
A 100.0
/100.0
2
/2
E2G051_HUMAN MHC class I antigen
6ggm[1] H ZN
ZINC ION[1 atoms]
A 100.0
/100.0
2
/2
E2G051_HUMAN MHC class I antigen
6ggm[2] I ZN
ZINC ION[1 atoms]
A 100.0
/100.0
2
/2
E2G051_HUMAN MHC class I antigen
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
358 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7bh8[1] C HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. A 100.0
/100.0
10
/10
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[1] A HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai.. C 100.0
/100.0
6
/6
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
358 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6ggm[15] J SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
3
/3
E2G051_HUMAN MHC class I antigen
6ggm[8] K SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
3
/3
E2G051_HUMAN MHC class I antigen
6ggm[14] P SO4
SULFATE ION[5 atoms]
C 100.0
/100.0
1
/1
E2G051_HUMAN MHC class I antigen
6gh1[8] Q SO4
SULFATE ION[5 atoms]
D 100.0
/100.0
3
/3
E2G051_HUMAN MHC class I antigen
6ghn[1] H SO4
SULFATE ION[5 atoms]
C 100.0
/100.0
2
/2
Q59EE1_HUMAN HLA class I histocompatibility antigen, E alpha ch..
6gl1[1] M SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
2
/2
E2G051_HUMAN MHC class I antigen
7p49[1] O SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
3
/3
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[1] R SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
1
/1
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[2] S SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
3
/3
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[2] DA SO4
SULFATE ION[5 atoms]
C 100.0
/100.0
1
/1
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p4b[1] N SO4
SULFATE ION[5 atoms]
A 100.0
/100.0
2
/2
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[7] K GOL
GLYCEROL[6 atoms]
A 100.0
/100.0
4
/4
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[4] L GOL
GLYCEROL[6 atoms]
A 100.0
/100.0
4
/4
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[1] M GOL
GLYCEROL[6 atoms]
A 100.0
/100.0
5
/5
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7bh8[4] N GOL
GLYCEROL[6 atoms]
A 100.0
/100.0
4
/4
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[1] N GOL
GLYCEROL[6 atoms]
A 100.0
/100.0
2
/2
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[1] EA GOL
GLYCEROL[6 atoms]
C 100.0
/100.0
3
/3
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[1] Z GOL
GLYCEROL[6 atoms]
C 100.0
/100.0
5
/5
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
7p49[1] IA GOL
GLYCEROL[6 atoms]
E 100.0
/100.0
1
/1
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
8qfy[1] K ACT
ACETATE ION[4 atoms]
F 100.0
/100.0
1
/1
HLAE_HUMAN HLA class I histocompatibility antigen, alpha chai..
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.