ID V1BR_HUMAN Reviewed; 424 AA. AC P47901; B0M0J6; Q5TZ00; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 24-JUL-2024, entry version 190. DE RecName: Full=Vasopressin V1b receptor {ECO:0000305}; DE Short=V1bR; DE AltName: Full=AVPR V1b; DE AltName: Full=AVPR V3; DE AltName: Full=Antidiuretic hormone receptor 1b; DE AltName: Full=Vasopressin V3 receptor; GN Name=AVPR1B {ECO:0000312|HGNC:HGNC:896}; Synonyms=AVPR3, VPR3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pituitary; RX PubMed=7929452; DOI=10.1016/s0021-9258(18)47129-3; RA Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S., RA Kawashima H.; RT "Molecular cloning and functional expression of a cDNA encoding the human RT V1b vasopressin receptor."; RL J. Biol. Chem. 269:27088-27092(1994). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pituitary; RX PubMed=7805841; DOI=10.1016/0014-5793(94)01268-7; RA de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M., Bertagna X., RA Clauser E.; RT "Cloning and characterization of the human V3 pituitary vasopressin RT receptor."; RL FEBS Lett. 356:215-220(1994). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Lung carcinoma; RX PubMed=9357056; DOI=10.1016/s0196-9781(97)00072-7; RA North W.G., Fay M.J., Longo K.A., Du J.; RT "Functional vasopressin V1 type receptors are present in variant as well as RT classical forms of small-cell carcinoma."; RL Peptides 18:985-993(1997). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=9581826; RA North W.G., Fay M.J., Longo K.A., Du J.; RT "Expression of all known vasopressin receptor subtypes by small cell tumors RT implies a multifaceted role for this neuropeptide."; RL Cancer Res. 58:1866-1871(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10607899; DOI=10.1016/s0378-1119(99)00468-0; RA Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.; RT "Nucleotide sequence and structural organization of the human vasopressin RT pituitary receptor (V3) gene."; RL Gene 241:57-64(2000). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RA Kaighin V.A., Martin A.L., Aronstam R.S.; RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-65; ARG-191; GLY-267 RP AND HIS-364. RG SeattleSNPs variation discovery resource; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [9] RP FUNCTION, INTERACTION WITH SARS-COV-2 SPIKE GLYCOPROTEIN (MICROBIAL RP FUNCTION), AND SUBCELLULAR LOCATION. RX PubMed=33713620; DOI=10.1016/j.cell.2021.02.053; RA Yeung M.L., Teng J.L.L., Jia L., Zhang C., Huang C., Cai J.P., Zhou R., RA Chan K.H., Zhao H., Zhu L., Siu K.L., Fung S.Y., Yung S., Chan T.M., RA To K.K., Chan J.F., Cai Z., Lau S.K.P., Chen Z., Jin D.Y., Woo P.C.Y., RA Yuen K.Y.; RT "Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with RT proteins related to the renin-angiotensin system."; RL Cell 0:0-0(2021). RN [10] RP VARIANTS ASN-65 AND HIS-364. RX PubMed=17909131; DOI=10.1001/archpsyc.64.10.1189; RA Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J., RA Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.; RT "Evidence of an association between the vasopressin V1b receptor gene RT (AVPR1B) and childhood-onset mood disorders."; RL Arch. Gen. Psychiatry 64:1189-1195(2007). CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate a phosphatidyl- CC inositol-calcium second messenger system. CC -!- FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 CC infection, may recognize and internalize the complex formed by AVP/Arg- CC vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through CC DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33713620}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE- CC ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=SeattleSNPs; CC URL="http://pga.gs.washington.edu/data/avpr1b/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D31833; BAA06621.1; -; mRNA. DR EMBL; L37112; AAA65687.1; -; mRNA. DR EMBL; AF030512; AAB84293.1; -; mRNA. DR EMBL; AF101726; AAD17892.1; -; mRNA. DR EMBL; AF152238; AAF33681.1; -; Genomic_DNA. DR EMBL; EU432111; ABY87910.1; -; mRNA. DR EMBL; DQ194816; ABA03171.1; -; Genomic_DNA. DR EMBL; BX571818; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS73015.1; -. DR PIR; A55089; A55089. DR RefSeq; NP_000698.1; NM_000707.3. DR AlphaFoldDB; P47901; -. DR SMR; P47901; -. DR BioGRID; 107034; 31. DR STRING; 9606.ENSP00000356094; -. DR BindingDB; P47901; -. DR ChEMBL; CHEMBL1921; -. DR DrugBank; DB09059; Atosiban. DR DrugBank; DB00035; Desmopressin. DR DrugBank; DB14642; Lypressin. DR DrugBank; DB05452; PH-284. DR DrugBank; DB05455; SR 121463. DR DrugBank; DB02638; Terlipressin. DR DrugBank; DB00067; Vasopressin. DR DrugCentral; P47901; -. DR GuidetoPHARMACOLOGY; 367; -. DR TCDB; 9.A.14.10.2; the g-protein-coupled receptor (gpcr) family. DR GlyCosmos; P47901; 1 site, No reported glycans. DR GlyGen; P47901; 1 site. DR iPTMnet; P47901; -. DR PhosphoSitePlus; P47901; -. DR BioMuta; AVPR1B; -. DR DMDM; 1351392; -. DR MassIVE; P47901; -. DR PaxDb; 9606-ENSP00000356094; -. DR PeptideAtlas; P47901; -. DR Antibodypedia; 20687; 406 antibodies from 36 providers. DR DNASU; 553; -. DR Ensembl; ENST00000367126.5; ENSP00000356094.4; ENSG00000198049.7. DR GeneID; 553; -. DR KEGG; hsa:553; -. DR MANE-Select; ENST00000367126.5; ENSP00000356094.4; NM_000707.5; NP_000698.1. DR UCSC; uc001hds.3; human. DR AGR; HGNC:896; -. DR CTD; 553; -. DR DisGeNET; 553; -. DR GeneCards; AVPR1B; -. DR HGNC; HGNC:896; AVPR1B. DR HPA; ENSG00000198049; Tissue enriched (pituitary). DR MIM; 600264; gene. DR neXtProt; NX_P47901; -. DR OpenTargets; ENSG00000198049; -. DR PharmGKB; PA25188; -. DR VEuPathDB; HostDB:ENSG00000198049; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01050000244882; -. DR HOGENOM; CLU_009579_15_3_1; -. DR InParanoid; P47901; -. DR OMA; FNSHLWP; -. DR OrthoDB; 2879183at2759; -. DR PhylomeDB; P47901; -. DR TreeFam; TF106499; -. DR PathwayCommons; P47901; -. DR Reactome; R-HSA-388479; Vasopressin-like receptors. DR Reactome; R-HSA-416476; G alpha (q) signalling events. DR Reactome; R-HSA-5619099; Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI). DR SignaLink; P47901; -. DR SIGNOR; P47901; -. DR BioGRID-ORCS; 553; 13 hits in 1155 CRISPR screens. DR GeneWiki; Arginine_vasopressin_receptor_1B; -. DR GenomeRNAi; 553; -. DR Pharos; P47901; Tclin. DR PRO; PR:P47901; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; P47901; Protein. DR Bgee; ENSG00000198049; Expressed in adenohypophysis and 43 other cell types or tissues. DR GO; GO:0005768; C:endosome; TAS:ProtInc. DR GO; GO:0005794; C:Golgi apparatus; IDA:ARUK-UCL. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0042277; F:peptide binding; IBA:GO_Central. DR GO; GO:0005080; F:protein kinase C binding; TAS:ProtInc. DR GO; GO:0005000; F:vasopressin receptor activity; IDA:ARUK-UCL. DR GO; GO:0007202; P:activation of phospholipase C activity; IDA:ARUK-UCL. DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:ARUK-UCL. DR GO; GO:0090238; P:positive regulation of arachidonic acid secretion; IDA:ARUK-UCL. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc. DR GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:ARUK-UCL. DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:ARUK-UCL. DR GO; GO:0032430; P:positive regulation of phospholipase A2 activity; IDA:ARUK-UCL. DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central. DR GO; GO:0042127; P:regulation of cell population proliferation; IDA:ARUK-UCL. DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central. DR GO; GO:0046718; P:symbiont entry into host cell; IDA:UniProtKB. DR GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL. DR CDD; cd15386; 7tmA_V1bR; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR015076; V1R_C. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR000628; Vprs_rcpt_V1B. DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24241:SF18; VASOPRESSIN V1B RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00897; VASOPRSNV1BR. DR SMART; SM01164; DUF1856; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..424 FT /note="Vasopressin V1b receptor" FT /id="PRO_0000070203" FT TOPO_DOM 1..35 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 36..59 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 60..71 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 72..93 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 94..108 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 109..130 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 131..151 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 152..173 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 174..201 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 202..222 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 223..283 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 284..303 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 304..321 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 322..341 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 342..424 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 398..417 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 21 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 107..186 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 65 FT /note="K -> N (in dbSNP:rs35369693)" FT /evidence="ECO:0000269|PubMed:17909131, ECO:0000269|Ref.7" FT /id="VAR_025159" FT VARIANT 191 FT /note="G -> R (in dbSNP:rs33990840)" FT /evidence="ECO:0000269|Ref.7" FT /id="VAR_025160" FT VARIANT 224 FT /note="H -> Q (in dbSNP:rs3891058)" FT /id="VAR_061228" FT VARIANT 267 FT /note="S -> G (in dbSNP:rs36030374)" FT /evidence="ECO:0000269|Ref.7" FT /id="VAR_025161" FT VARIANT 364 FT /note="R -> H (in dbSNP:rs28632197)" FT /evidence="ECO:0000269|PubMed:17909131, ECO:0000269|Ref.7" FT /id="VAR_025162" SQ SEQUENCE 424 AA; 46971 MW; 35190281D3EDB6A7 CRC64; MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE TIIF //