Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 M -1 -2 -2 -3 -2 -1 -2 -3 -2 1 2 -2 6 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0.43 0.02 2 A 4 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -1 -2 -1 1 0 -3 -2 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.43 0.01 3 S 0 -2 -1 -1 -2 -1 -1 -2 -2 -3 -3 -1 -2 -4 7 2 0 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 71 29 0 0 0 0 1.35 0.01 4 T 1 -1 0 -1 -1 0 -1 -1 -1 -2 -2 -1 -1 -2 -1 3 4 -3 -2 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 45 55 0 0 0 0.41 0.01 5 S -1 -2 -2 -2 -2 -2 -2 -2 -1 -1 0 -2 0 6 -3 1 -1 0 2 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 71 0 29 0 0 0 0 0.43 0.01 6 Y -2 -2 -2 -3 -3 -2 -2 -3 2 -2 -1 -2 -1 3 -3 -2 -2 2 7 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0.94 0.02 7 D -2 -1 1 3 -3 0 0 -2 7 -4 -3 -1 -2 -2 -2 -1 -2 -3 1 -3 0 0 0 29 0 0 0 0 71 0 0 0 0 0 0 0 0 0 0 0 0.70 0.02 8 Y -2 -2 -2 -3 -3 -2 -2 -3 2 -2 -1 -2 -1 3 -3 -2 -2 2 7 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0.94 0.02 9 C -1 -2 -2 -3 6 -2 -2 -3 4 0 2 -2 1 -1 -3 -2 -1 -2 0 0 0 0 0 0 29 0 0 0 26 0 45 0 0 0 0 0 0 0 0 0 0.34 0.01 10 R -1 3 -2 -2 -3 -1 -1 -2 -2 -3 -3 0 -2 -4 7 -1 -1 -4 -3 -3 0 29 0 0 0 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0 1.36 0.01 11 V -1 -3 -3 -4 -1 -2 -3 -4 -3 2 2 -3 1 -1 -3 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0 0 0 0 0 74 0.33 0.01 12 P 1 -2 -2 -2 -2 -1 -1 -2 -2 -3 -3 -1 -2 -4 7 0 -1 -4 -3 -2 24 0 0 0 0 0 0 0 0 0 0 0 0 0 76 0 0 0 0 0 1.45 0.01 13 M -1 -2 -2 -3 -2 -1 -2 -3 -2 1 2 -2 6 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0.43 0.02 14 E -2 -1 1 6 -4 0 3 -2 -1 -3 -4 0 -3 -4 -2 0 -1 -4 -3 -3 0 0 0 71 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0.78 0.01 15 D -1 0 0 4 -4 3 4 -2 0 -3 -3 1 -2 -4 -1 0 -1 -3 -2 -3 0 0 0 29 0 26 45 0 0 0 0 0 0 0 0 0 0 0 0 0 0.59 0.01 16 G 0 0 0 -1 -3 -1 -1 5 -2 -4 -4 2 -3 -3 -2 0 -1 -3 -3 -3 0 0 0 0 0 0 0 74 0 0 0 26 0 0 0 0 0 0 0 0 0.70 0.01 17 D -2 -2 -1 3 -3 0 2 -2 -1 -3 -3 -1 -2 -1 -2 -1 -2 9 0 -3 0 0 0 29 0 0 26 0 0 0 0 0 0 0 0 0 0 45 0 0 0.99 0.01 18 K 0 0 0 -1 -2 0 0 2 -1 -3 -3 2 -2 -3 4 1 0 -3 -2 -3 0 0 0 0 0 0 0 22 0 0 0 29 0 0 26 24 0 0 0 0 0.48 0.01 19 R 0 3 -1 -2 -2 -1 -1 2 -1 1 -1 0 -1 -2 -2 1 0 -3 -2 0 0 29 0 0 0 0 0 26 0 24 0 0 0 0 0 22 0 0 0 0 0.17 0.00 20 C -1 2 -1 -3 8 -1 -2 -3 4 -2 -2 -1 -2 -2 -3 -1 -1 -3 -1 -2 0 24 0 0 55 0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0.61 0.01 21 K -1 4 0 -1 -3 1 0 2 -1 -3 -3 3 -2 -3 -2 -1 -1 -3 -2 -3 0 45 0 0 0 0 0 26 0 0 0 29 0 0 0 0 0 0 0 0 0.46 0.01 22 L -2 -2 -2 -3 -2 2 -1 -3 -2 2 2 -1 1 0 -3 -2 -1 7 0 1 0 0 0 0 0 22 0 0 0 26 29 0 0 0 0 0 0 24 0 0 0.40 0.01 23 L -2 2 -3 -3 -2 -1 -2 -3 -2 -1 1 -1 0 0 -3 -2 -2 9 1 -1 0 26 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 45 0 0 0.86 0.01 24 L -2 -3 -4 -4 -2 -2 -3 -4 -3 1 4 -3 1 1 -3 -3 -2 7 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 0 0 0 0 26 0 0 0.64 0.01 25 G 0 2 -1 -2 -2 -1 -2 4 -2 -1 -2 0 -1 -3 -2 -1 -1 -3 -2 1 0 26 0 0 0 0 0 51 0 0 0 0 0 0 0 0 0 0 0 24 0.35 0.01 26 I 2 -2 -3 -3 -1 -2 -2 -1 -3 2 2 -2 1 -1 -2 0 -1 -3 -2 1 45 0 0 0 0 0 0 0 0 29 26 0 0 0 0 0 0 0 0 0 0.18 0.01 27 G 4 -2 -1 -2 -1 -1 -1 3 -2 -2 -2 -1 -2 -3 -1 1 0 -3 -2 -1 71 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 0.42 0.01 28 I 1 -3 -3 -3 -1 -2 -3 -2 -3 4 1 -2 1 -1 -2 -1 -1 -3 -2 2 26 0 0 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0.25 0.01 29 L 1 -2 -3 -3 -1 -2 -2 -2 -3 1 3 -2 2 0 -2 -1 -1 -2 -1 1 26 0 0 0 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0.28 0.01 30 V 0 -2 -2 -2 -1 -2 -2 -2 -3 2 0 -2 0 -1 -2 1 0 -3 -1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 74 0.22 0.01 31 L -1 -3 -3 -4 -1 -2 -3 -4 -3 2 2 -3 1 -1 -3 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 71 0.33 0.01 32 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 33 I -2 -3 -3 -4 -2 -3 -4 -4 -3 4 1 -3 1 3 -3 -3 -1 -2 0 2 0 0 0 0 0 0 0 0 0 78 0 0 0 22 0 0 0 0 0 0 0.35 0.01 34 I -1 -3 -2 -2 -2 -2 -3 4 -3 2 1 -2 0 -1 -3 -1 -1 -2 -2 1 0 0 0 0 0 0 0 45 0 29 26 0 0 0 0 0 0 0 0 0 0.30 0.01 35 V 0 -3 -3 -3 -1 -2 -3 -3 -3 3 1 -3 1 -1 -3 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.38 0.01 36 I 2 -2 -2 -2 -1 -2 -2 -2 -3 2 0 -2 0 -1 -2 0 2 -3 -2 2 26 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 22 0 0 24 0.18 0.00 37 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 38 G 0 -3 -2 -3 -1 -2 -3 3 -3 2 0 -2 0 -2 -3 -1 -1 -3 -2 3 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 71 0.26 0.01 39 V -1 -3 -3 -4 5 -3 -3 -4 -3 3 1 -3 1 -1 -3 -2 -1 -3 -2 3 0 0 0 0 24 0 0 0 0 48 0 0 0 0 0 0 0 0 0 29 0.37 0.01 40 P -1 -2 -3 -3 -2 -2 -2 -3 -3 0 2 -2 0 -1 6 -2 -1 -3 -2 -1 0 0 0 0 0 0 0 0 0 0 45 0 0 0 55 0 0 0 0 0 0.90 0.01 41 L -1 -2 -2 -3 -1 -2 -3 -3 -3 2 3 -2 1 0 -3 -1 2 -2 -1 1 0 0 0 0 0 0 0 0 0 24 55 0 0 0 0 0 22 0 0 0 0.27 0.01 42 I -1 -3 -3 -3 -1 -3 -3 -4 -4 4 1 -3 1 0 -3 -2 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 76 0 0 0 0 0 0 0 0 0 24 0.39 0.01 43 I -2 -3 -3 -3 -2 -2 -3 -4 0 3 1 -3 0 2 -3 -2 -1 0 5 1 0 0 0 0 0 0 0 0 0 55 0 0 0 0 0 0 0 0 45 0 0.39 0.01 44 F -2 -3 -3 -4 -3 -4 -4 -3 -1 0 0 -3 0 7 -4 -3 -2 1 3 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0.80 0.02 45 T 4 -1 -1 -2 -1 -1 -1 0 -2 -1 -2 -1 -1 -2 -1 1 2 -3 -2 0 71 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0.34 0.01 46 I -1 -2 2 -2 -1 -2 -2 -3 -2 3 0 -2 0 -1 -3 -1 0 -3 -2 3 0 0 24 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 48 0.20 0.01 47 K 1 1 0 -1 -2 1 0 -1 -1 -2 -2 3 -1 -3 -1 1 2 -3 -2 -1 24 0 0 0 0 0 0 0 0 0 0 55 0 0 0 0 22 0 0 0 0.28 0.01 48 A 4 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -1 -2 -1 1 0 -3 -2 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.43 0.01 49 N -2 -1 6 1 -3 0 0 -1 5 -4 -4 0 -2 -3 -2 0 0 -4 -1 -3 0 0 76 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0.64 0.01 50 S 1 -1 1 0 -1 0 0 0 -1 -3 -3 0 -2 -3 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0.49 0.02 51 E -1 -1 -1 1 -3 1 5 -3 -1 -1 -2 0 -1 -3 -2 -1 -1 -3 -2 1 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 0 0 0 0 22 0.46 0.01 52 A 4 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -1 -2 -1 1 0 -3 -2 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.43 0.01 53 C -1 -4 -3 -4 9 -3 -4 -3 -3 -1 -2 -3 -2 -3 -3 -1 -1 -3 -3 -1 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.32 0.02 54 R -1 5 0 -2 -4 1 0 -2 0 -3 -2 3 -2 -3 -2 -1 -1 -3 -2 -3 0 76 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0.67 0.01 55 D -2 -1 3 6 -4 0 1 -1 -1 -3 -4 -1 -3 -4 -2 0 -1 -4 -3 -3 0 0 24 76 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.79 0.01 56 G 0 -3 -1 -1 -3 -2 -2 6 -2 -4 -4 -2 -3 -3 -2 0 -2 -3 -3 -3 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.08 0.01 57 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 58 R -2 6 -1 -2 -4 1 0 -3 0 -3 -2 2 -2 -3 -2 -1 -1 -3 -2 -3 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.80 0.02 59 A 4 -2 -2 -2 -1 -1 -1 0 -2 0 1 -1 0 -2 -1 1 0 -3 -2 0 76 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0.26 0.01 60 V -1 0 -1 -1 -2 5 1 -2 0 0 -1 1 0 -3 -2 -1 -1 -2 -2 1 0 0 0 0 0 71 0 0 0 0 0 0 0 0 0 0 0 0 0 29 0.37 0.01 61 M 1 -1 0 3 -2 0 2 -2 -1 -1 0 0 3 -2 -2 0 -1 -3 -2 -1 22 0 0 24 0 0 26 0 0 0 0 0 29 0 0 0 0 0 0 0 0.21 0.01 62 E -1 0 0 2 -4 2 5 -2 0 -4 -3 1 -2 -4 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.02 63 C -1 -4 -3 -4 9 -3 -4 -3 -3 -1 -2 -3 -2 -3 -3 -1 -1 -3 -3 -1 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.32 0.02 64 R -1 5 0 -1 -3 1 0 -2 0 -3 -2 2 -2 -3 -2 1 0 -3 -2 -3 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0 0.55 0.01 65 N -2 -1 6 1 -3 0 0 -1 1 -4 -4 0 -2 -3 -2 1 0 -4 -2 -3 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.78 0.02 66 V 0 -2 -1 -2 -1 -1 -1 -2 -2 1 -1 -1 0 -2 -2 1 4 -3 -2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 71 0 0 29 0.33 0.01 67 T 0 -1 0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1 1 5 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0.51 0.02 68 H -2 3 0 -1 -3 1 0 -2 7 -4 -3 0 -2 -2 -2 -1 -2 -3 1 -3 0 26 0 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0.71 0.02 69 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 70 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 71 Q -1 1 0 -1 -3 5 2 -2 0 -3 -2 3 -1 -3 -1 0 -1 -2 -2 -2 0 0 0 0 0 76 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0.59 0.01 72 Q -1 4 0 -1 -3 3 1 -2 4 -3 -3 1 -1 -3 -2 -1 -1 -3 -1 -3 0 48 0 0 0 29 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0.51 0.01 73 E -1 1 0 0 -3 5 3 -2 0 -3 -3 1 -1 -4 -1 0 -1 -2 -2 -3 0 0 0 0 0 71 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0.63 0.01 74 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 75 T 0 -1 0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1 1 5 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0.51 0.02 76 E -1 5 0 0 -4 1 3 -2 0 -3 -3 2 -2 -3 -2 -1 -1 -3 -2 -3 0 71 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0.61 0.01 77 A 3 -1 -1 -1 -1 -1 -1 0 -2 -2 -2 -1 -1 -2 -1 2 2 -3 -2 -1 52 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 22 0 0 0 0.32 0.01 78 Q -1 1 0 0 -3 6 2 -2 0 -3 -2 1 -1 -4 -2 0 -1 -2 -2 -2 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.71 0.02 79 K -2 0 1 5 -4 0 1 -2 -1 -3 -4 2 -3 -4 -2 0 -1 -4 -3 -3 0 0 0 71 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0.66 0.01 80 G 0 -1 3 0 -2 -1 -1 3 -1 -3 -3 -1 -2 -3 -2 3 0 -3 -2 -3 0 0 26 0 0 0 0 29 0 0 0 0 0 0 0 45 0 0 0 0 0.42 0.01 81 F -2 -3 -4 -4 -2 -3 -3 -4 -2 1 4 -3 2 4 -3 -3 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 71 0 0 29 0 0 0 0 0 0 0.41 0.01 82 Q 1 -1 -2 -2 -2 3 0 -2 -1 0 2 -1 1 -1 -2 -1 -1 -2 -1 0 26 0 0 0 0 29 0 0 0 0 45 0 0 0 0 0 0 0 0 0 0.16 0.01 83 D -1 0 0 3 -3 5 2 -2 0 -3 -3 1 -1 -4 -2 0 -1 -3 -2 -3 0 0 0 29 0 71 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.58 0.01 84 V 3 -2 -2 -2 -1 -1 -1 -1 -2 0 -1 -1 0 -2 -1 1 2 -3 -2 2 48 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 29 0.21 0.01 85 E -1 0 0 2 -4 2 5 -2 0 -4 -3 1 -2 -4 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.02 86 A 3 -1 -1 -2 -1 -1 -1 -1 -2 -1 0 -1 3 -2 -1 1 2 -2 -2 0 55 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 22 0 0 0 0.22 0.01 87 Q -1 1 0 0 -3 6 2 -2 0 -3 -2 1 -1 -4 -2 0 -1 -2 -2 -2 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.71 0.02 88 A 4 -2 -2 -2 -1 -1 -1 0 -2 -2 -2 -1 -1 -2 -1 1 0 -3 -2 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.43 0.01 89 A 2 -1 4 0 -2 0 0 0 0 -3 -3 0 -2 -3 -1 2 0 -3 -2 -2 29 0 45 0 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 0 0.37 0.01 90 T 1 -1 0 -1 -1 0 -1 -1 -1 -2 -2 -1 -1 -2 -1 3 4 -3 -2 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 45 55 0 0 0 0.41 0.01 91 C -1 -4 -3 -4 9 -3 -4 -3 -3 -1 -2 -3 -2 -3 -3 -1 -1 -3 -3 -1 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.32 0.02 92 N -2 -1 6 1 -3 0 0 -1 1 -4 -4 0 -2 -3 -2 1 0 -4 -2 -3 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.78 0.02 93 H -1 3 0 -2 -3 3 0 -3 5 -1 1 1 0 -2 -2 -1 -1 -2 0 -2 0 26 0 0 0 24 0 0 29 0 22 0 0 0 0 0 0 0 0 0 0.29 0.01 94 T 0 -1 0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1 1 5 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0.51 0.02 95 V 0 -3 -3 -3 -1 -2 -3 -3 -3 3 1 -3 1 -1 -3 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.38 0.01 96 M -1 -2 -3 -3 -1 -1 -2 -3 -2 2 2 -2 5 0 -3 -2 0 -2 -1 3 0 0 0 0 0 0 0 0 0 0 0 0 52 0 0 0 0 0 0 48 0.30 0.01 97 A 2 -1 0 3 -1 -1 0 -1 -2 -1 -2 -1 -1 -3 -1 1 3 -3 -2 -1 29 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 48 0 0 0 0.30 0.01 98 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 99 M -1 3 -1 -1 -3 4 1 -2 0 -1 0 1 3 -2 -2 -1 -1 -2 -2 -1 0 24 0 0 0 48 0 0 0 0 0 0 29 0 0 0 0 0 0 0 0.34 0.01 100 A 1 -1 0 5 -2 0 3 -1 -1 -3 -3 0 -2 -3 -1 0 -1 -4 -3 -2 29 0 0 49 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0.47 0.01 101 S 1 -1 1 0 -1 0 0 0 -1 -3 -3 0 -2 -3 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0.49 0.02 102 L -2 -2 -4 -4 -1 -2 -3 -4 -3 2 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0.48 0.01 103 D -1 0 0 4 -4 1 4 -2 -1 -3 -3 2 -2 -4 -1 0 -1 -4 -2 -3 0 0 0 29 0 0 48 0 0 0 0 24 0 0 0 0 0 0 0 0 0.54 0.01 104 A 2 2 -1 -1 -2 1 0 -1 -1 -2 -2 4 -1 -3 -1 0 -1 -3 -2 -2 29 0 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0 0 0 0 0.36 0.01 105 E -1 2 0 0 -4 2 3 -2 -1 -3 -3 4 -2 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 29 0 0 0 0 71 0 0 0 0 0 0 0 0 0.49 0.01 106 K 0 0 -2 -2 -1 -1 -1 -3 -2 2 0 2 0 -2 -2 -1 0 -3 -2 3 0 0 0 0 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 71 0.19 0.01 107 A 2 -1 0 -1 -1 0 0 0 -1 -2 -2 0 -1 -3 -1 4 1 -3 -2 -1 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0.39 0.01 108 Q -1 1 0 0 -3 6 2 -2 0 -3 -2 1 -1 -4 -2 0 -1 -2 -2 -2 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.71 0.02 109 G 1 -2 -1 -2 -1 -2 -2 3 -2 1 -1 -1 -1 -2 -2 0 2 -3 -2 0 22 0 0 0 0 0 0 29 0 26 0 0 0 0 0 0 24 0 0 0 0.20 0.00 110 Q -1 1 0 0 -3 6 2 -2 0 -3 -2 1 -1 -4 -2 0 -1 -2 -2 -2 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.71 0.02 111 K 1 1 -1 0 -3 1 4 -1 -1 -3 -3 2 -2 -3 -1 0 -1 -3 -2 -2 22 0 0 0 0 0 49 0 0 0 0 29 0 0 0 0 0 0 0 0 0.39 0.01 112 K -1 5 0 -1 -4 1 0 -2 -1 -3 -3 4 -2 -3 -2 -1 -1 -3 -2 -3 0 45 0 0 0 0 0 0 0 0 0 55 0 0 0 0 0 0 0 0 0.57 0.01 113 V -1 -3 -3 -3 -1 -3 -3 -4 -4 4 1 -3 1 0 -3 -2 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 71 0 0 0 0 0 0 0 0 0 29 0.38 0.01 114 E -1 1 0 0 -3 3 3 -2 0 -3 -3 3 -1 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 26 29 0 0 0 0 45 0 0 0 0 0 0 0 0 0.48 0.01 115 E -1 0 0 2 -4 2 5 -2 0 -4 -3 1 -2 -4 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.02 116 L -1 -1 -2 -3 -2 2 -1 -3 -2 1 3 -1 2 0 -3 -2 -1 -2 -1 0 0 0 0 0 0 26 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0.28 0.01 117 E -1 0 0 2 -4 2 5 -2 0 -4 -3 1 -2 -4 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0.77 0.02 118 G 1 -1 4 0 -2 -1 -1 3 -1 -3 -3 -1 -2 -3 -2 1 0 -3 -2 -2 26 0 45 0 0 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0 0.42 0.01 119 E -1 1 0 1 -4 3 4 -2 0 -3 -3 2 -2 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 26 51 0 0 0 0 24 0 0 0 0 0 0 0 0 0.54 0.01 120 I -1 -3 -3 -3 -1 -3 -3 -4 -4 4 1 -3 1 0 -3 -2 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 0 22 0.39 0.01 121 T 0 0 0 0 -2 1 2 -2 -1 -2 -2 2 -1 -3 -1 1 3 -3 -2 -1 0 0 0 0 0 0 24 0 0 0 0 26 0 0 0 0 51 0 0 0 0.32 0.01 122 T -1 3 0 0 -3 1 2 -2 -1 -2 -2 2 -1 -3 -1 0 2 -3 -2 -2 0 24 0 0 0 0 26 0 0 0 0 22 0 0 0 0 29 0 0 0 0.34 0.01 123 L -1 -1 -2 -3 -2 2 -1 -3 -2 1 3 -1 2 0 -3 -2 -1 -2 -1 0 0 0 0 0 0 26 0 0 0 0 74 0 0 0 0 0 0 0 0 0 0.28 0.01 124 N -2 0 5 1 -3 1 2 -1 0 -4 -4 0 -2 -3 -2 0 0 -4 -2 -3 0 0 74 0 0 0 26 0 0 0 0 0 0 0 0 0 0 0 0 0 0.61 0.01 125 H 1 0 0 -1 -2 4 1 -1 5 -3 -2 0 -1 -2 -2 0 -1 -2 0 -2 26 0 0 0 0 45 0 0 29 0 0 0 0 0 0 0 0 0 0 0 0.38 0.01 126 K -1 1 0 1 -4 3 4 -2 0 -3 -3 3 -1 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 26 45 0 0 0 0 29 0 0 0 0 0 0 0 0 0.52 0.01 127 L -2 -3 -4 -4 -1 -3 -3 -4 -3 3 4 -3 2 0 -3 -3 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 26 74 0 0 0 0 0 0 0 0 0 0.41 0.01 128 Q -1 1 0 1 -4 4 4 -2 0 -3 -3 3 -1 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 29 45 0 0 0 0 26 0 0 0 0 0 0 0 0 0.53 0.01 129 D -2 -1 4 4 -3 1 3 -1 0 -3 -4 0 -3 -3 -2 0 -1 -4 -3 -3 0 0 45 29 0 0 26 0 0 0 0 0 0 0 0 0 0 0 0 0 0.57 0.01 130 A 2 -1 -1 -2 -1 3 0 -1 -1 0 2 0 1 -1 -2 0 -1 -2 -2 0 34 0 0 0 0 33 0 0 0 0 33 0 0 0 0 0 0 0 0 0 0.17 0.00 131 S 0 3 0 0 -3 1 3 -2 0 -3 -3 1 -2 -3 -1 2 0 -3 -2 -2 0 33 0 0 0 0 33 0 0 0 0 0 0 0 0 34 0 0 0 0 0.38 0.01 132 A 3 -1 -1 -2 -1 -1 -1 0 -2 -1 -2 -1 -1 -2 -1 1 3 -3 -2 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 0 0.33 0.01 133 E -1 1 0 0 -3 5 4 -2 0 -3 -3 1 -1 -3 -1 0 -1 -2 -2 -3 0 0 0 0 0 66 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0.62 0.01 134 V -1 0 -2 -2 -2 -1 -1 -3 -2 3 0 2 0 -1 -2 -1 -1 -3 -2 3 0 0 0 0 0 0 0 0 0 33 0 33 0 0 0 0 0 0 0 34 0.16 0.00 135 E -1 1 0 1 -4 2 4 -2 0 -3 -3 3 -2 -3 -1 0 -1 -3 -2 -3 0 0 0 0 0 0 67 0 0 0 0 33 0 0 0 0 0 0 0 0 0.57 0.01 136 R -1 4 0 0 -4 2 4 -2 0 -3 -3 2 -2 -3 -2 0 -1 -3 -2 -3 0 50 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 0 0.55 0.00 137 L -1 0 -1 -2 -2 4 0 -3 -1 0 2 0 1 -1 -2 -1 -1 -2 -1 0 0 0 0 0 0 50 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0.25 0.00 138 R -1 5 0 -1 -3 1 0 -2 -1 -3 -2 4 -1 -3 -2 -1 -1 -3 -2 -3 0 50 0 0 0 0 0 0 0 0 0 50 0 0 0 0 0 0 0 0 0.56 0.00 139 R 3 4 -1 -2 -2 0 -1 -1 -1 -2 -2 1 -1 -3 -2 0 -1 -3 -2 -1 50 50 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.35 0.00 140 E -1 0 0 1 -4 1 4 -2 6 -3 -3 0 -2 -2 -2 -1 -1 -3 0 -3 0 0 0 0 0 0 50 0 50 0 0 0 0 0 0 0 0 0 0 0 0.58 0.00 141 N -2 -2 4 0 -2 -1 -2 -2 -1 2 0 -1 0 -1 -3 -1 0 -3 -2 1 0 0 50 0 0 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 0.22 0.00 142 Q -1 1 0 0 -3 6 2 -2 0 -3 -2 1 0 -3 -1 0 -1 -2 -2 -2 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.66 0.00 143 V -1 -1 -1 0 -2 1 3 -3 -1 1 -1 0 0 -2 -2 -1 0 -3 -2 2 0 0 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 50 0.24 0.00 144 L -1 0 -1 -2 -2 4 0 -3 -1 0 2 0 1 -1 -2 -1 -1 -2 -1 0 0 0 0 0 0 50 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0.25 0.00 145 S 0 0 0 0 -2 4 1 -1 0 -3 -2 1 -1 -3 -1 3 1 -3 -2 -2 0 0 0 0 0 50 0 0 0 0 0 0 0 0 0 50 0 0 0 0 0.40 0.00 146 V 0 -3 -3 -3 -1 -2 -3 -3 -3 3 1 -2 1 -1 -3 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0.35 0.00 147 R -2 6 0 -2 -4 1 0 -3 0 -3 -2 2 -2 -3 -2 -1 -1 -3 -2 -3 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.75 0.00 148 I -1 -3 -4 -3 -1 -3 -3 -4 -4 4 2 -3 1 0 -3 -3 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0.39 0.00 149 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 150 D -2 -2 1 6 -3 0 2 -1 -1 -3 -4 -1 -3 -3 -1 0 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 151 K -1 2 0 -1 -3 1 1 -2 -1 -3 -2 4 -1 -3 -1 0 -1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 152 K -1 2 0 -1 -3 1 1 -2 -1 -3 -2 4 -1 -3 -1 0 -1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 153 Y -2 -2 -2 -3 -2 -1 -2 -3 2 -1 -1 -2 -1 3 -3 -2 -2 2 7 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 154 Y -2 -2 -2 -3 -2 -1 -2 -3 2 -1 -1 -2 -1 3 -3 -2 -2 2 7 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 155 P -1 -2 -2 -1 -3 -1 -1 -2 -2 -3 -3 -1 -2 -4 7 -1 -1 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 156 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 157 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 158 Q -1 1 0 0 -3 5 2 -2 0 -3 -2 1 0 -3 -1 0 -1 -2 -1 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 159 D -2 -2 1 6 -3 0 2 -1 -1 -3 -4 -1 -3 -3 -1 0 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 160 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 161 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 162 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 163 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 164 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 165 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 166 P -1 -2 -2 -1 -3 -1 -1 -2 -2 -3 -3 -1 -2 -4 7 -1 -1 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 167 Q -1 1 0 0 -3 5 2 -2 0 -3 -2 1 0 -3 -1 0 -1 -2 -1 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 168 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 169 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 170 I -1 -3 -3 -3 -1 -3 -3 -4 -3 4 2 -3 1 0 -3 -2 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 171 V 0 -2 -3 -3 -1 -2 -2 -3 -3 3 1 -2 1 -1 -2 -2 0 -3 -1 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 172 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 173 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 174 G 0 -2 0 -1 -2 -2 -2 6 -2 -4 -4 -2 -3 -3 -2 0 -2 -2 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 175 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 176 S 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 177 A 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 178 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 179 L -1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 180 Q -1 1 0 0 -3 5 2 -2 0 -3 -2 1 0 -3 -1 0 -1 -2 -1 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.00 0.00 K Lambda Standard Ungapped 0.1322 0.3184 Standard Gapped 0.0410 0.2670 PSI Ungapped 0.1322 0.3184 PSI Gapped 0.0410 0.2670