PSIBLAST 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Stephen F.
Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005)
"Protein database searches using compositionally adjusted
substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: uniprot_sprot.fasta
571,282 sequences; 206,678,396 total letters
Results from round 1
Query= sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute
respiratory syndrome coronavirus OX=694009 GN=1a PE=1 SV=1
Length=4382
Score E
Sequences producing significant alignments: (Bits) Value
sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute respi... 9140 0.0
sp|P0C6X7|R1AB_SARS Replicase polyprotein 1ab OS=Severe acute res... 9103 0.0
sp|P0C6T7|R1A_BCRP3 Replicase polyprotein 1a OS=Bat coronavirus R... 8851 0.0
sp|P0C6W6|R1AB_BCRP3 Replicase polyprotein 1ab OS=Bat coronavirus... 8819 0.0
sp|P0C6F8|R1A_BCHK3 Replicase polyprotein 1a OS=Bat coronavirus H... 8575 0.0
sp|P0C6W2|R1AB_BCHK3 Replicase polyprotein 1ab OS=Bat coronavirus... 8550 0.0
sp|P0C6F5|R1A_BC279 Replicase polyprotein 1a OS=Bat coronavirus 2... 8523 0.0
sp|P0C6V9|R1AB_BC279 Replicase polyprotein 1ab OS=Bat coronavirus... 8491 0.0
sp|P0DTC1|R1A_SARS2 Replicase polyprotein 1a OS=Severe acute resp... 7506 0.0
sp|P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab OS=Severe acute re... 7477 0.0
sp|P0C6T5|R1A_BCHK5 Replicase polyprotein 1a OS=Bat coronavirus H... 2341 0.0
sp|P0C6W4|R1AB_BCHK5 Replicase polyprotein 1ab OS=Bat coronavirus... 2335 0.0
sp|P0C6T6|R1A_BCHK9 Replicase polyprotein 1a OS=Bat coronavirus H... 2294 0.0
sp|P0C6W5|R1AB_BCHK9 Replicase polyprotein 1ab OS=Bat coronavirus... 2289 0.0
sp|K9N638|R1A_MERS1 Replicase polyprotein 1a OS=Middle East respi... 2189 0.0
sp|K9N7C7|R1AB_MERS1 Replicase polyprotein 1ab OS=Middle East res... 2184 0.0
sp|P0C6T9|R1A_CVBLU Replicase polyprotein 1a OS=Bovine coronaviru... 1897 0.0
sp|P0C6T8|R1A_CVBEN Replicase polyprotein 1a OS=Bovine coronaviru... 1895 0.0
sp|P0C6U7|R1A_CVHOC Replicase polyprotein 1a OS=Human coronavirus... 1890 0.0
sp|P0C6W8|R1AB_CVBLU Replicase polyprotein 1ab OS=Bovine coronavi... 1889 0.0
sp|P0C6W7|R1AB_CVBEN Replicase polyprotein 1ab OS=Bovine coronavi... 1887 0.0
sp|P0C6U1|R1A_CVBQ Replicase polyprotein 1a OS=Bovine coronavirus... 1884 0.0
sp|P0C6U0|R1A_CVBM Replicase polyprotein 1a OS=Bovine coronavirus... 1883 0.0
sp|P0C6X6|R1AB_CVHOC Replicase polyprotein 1ab OS=Human coronavir... 1883 0.0
sp|P0C6X0|R1AB_CVBQ Replicase polyprotein 1ab OS=Bovine coronavir... 1879 0.0
sp|P0C6W9|R1AB_CVBM Replicase polyprotein 1ab OS=Bovine coronavir... 1876 0.0
sp|P0C6U9|R1A_CVM2 Replicase polyprotein 1a OS=Murine coronavirus... 1869 0.0
sp|P0C6X8|R1AB_CVM2 Replicase polyprotein 1ab OS=Murine coronavir... 1864 0.0
sp|P0C6V0|R1A_CVMA5 Replicase polyprotein 1a OS=Murine coronaviru... 1860 0.0
sp|P0C6V1|R1A_CVMJH Replicase polyprotein 1a OS=Murine coronaviru... 1854 0.0
sp|P0C6X9|R1AB_CVMA5 Replicase polyprotein 1ab OS=Murine coronavi... 1852 0.0
sp|P0C6Y0|R1AB_CVMJH Replicase polyprotein 1ab OS=Murine coronavi... 1846 0.0
sp|P0C6U4|R1A_CVHN2 Replicase polyprotein 1a OS=Human coronavirus... 1819 0.0
sp|P0C6U5|R1A_CVHN5 Replicase polyprotein 1a OS=Human coronavirus... 1815 0.0
sp|P0C6U3|R1A_CVHN1 Replicase polyprotein 1a OS=Human coronavirus... 1814 0.0
sp|P0C6X3|R1AB_CVHN2 Replicase polyprotein 1ab OS=Human coronavir... 1812 0.0
sp|P0C6X4|R1AB_CVHN5 Replicase polyprotein 1ab OS=Human coronavir... 1809 0.0
sp|P0C6X2|R1AB_CVHN1 Replicase polyprotein 1ab OS=Human coronavir... 1806 0.0
sp|P0C6F6|R1A_BC512 Replicase polyprotein 1a OS=Bat coronavirus 5... 1209 0.0
sp|P0C6W0|R1AB_BC512 Replicase polyprotein 1ab OS=Bat coronavirus... 1209 0.0
sp|P0C6V6|R1A_PEDV7 Replicase polyprotein 1a OS=Porcine epidemic ... 1192 0.0
sp|P0C6Y4|R1AB_PEDV7 Replicase polyprotein 1ab OS=Porcine epidemi... 1189 0.0
sp|P0C6U2|R1A_CVH22 Replicase polyprotein 1a OS=Human coronavirus... 1186 0.0
sp|P0C6X1|R1AB_CVH22 Replicase polyprotein 1ab OS=Human coronavir... 1186 0.0
sp|P0C6X5|R1AB_CVHNL Replicase polyprotein 1ab OS=Human coronavir... 1179 0.0
sp|P0C6U6|R1A_CVHNL Replicase polyprotein 1a OS=Human coronavirus... 1178 0.0
sp|Q98VG9|R1AB_FIPV Replicase polyprotein 1ab OS=Feline coronavir... 1120 0.0
sp|P0C6V2|R1A_CVPPU Replicase polyprotein 1a OS=Porcine transmiss... 1113 0.0
sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmi... 1111 0.0
sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious ... 1100 0.0
sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious b... 1100 0.0
sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious b... 1097 0.0
sp|P0C6Y2|R1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectiou... 1093 0.0
sp|P0C6Y1|R1AB_IBVB Replicase polyprotein 1ab OS=Avian infectious... 1093 0.0
sp|P0C6Y3|R1AB_IBVM Replicase polyprotein 1ab OS=Avian infectious... 1092 0.0
sp|P0C6T4|R1A_BCHK4 Replicase polyprotein 1a OS=Bat coronavirus H... 311 7e-83
sp|P0C6W3|R1AB_BCHK4 Replicase polyprotein 1ab OS=Bat coronavirus... 310 1e-82
sp|P0C6F7|R1A_BC133 Replicase polyprotein 1a OS=Bat coronavirus 1... 308 5e-82
sp|P0C6W1|R1AB_BC133 Replicase polyprotein 1ab OS=Bat coronavirus... 308 5e-82
sp|Q97UU4|Y2899_SACS2 Uncharacterized protein SSO2899 OS=Saccharo... 68.2 5e-11
sp|Q8ZXT3|Y1111_PYRAE Uncharacterized protein PAE1111 OS=Pyrobacu... 68.2 5e-11
sp|Q9WYX8|Y508_THEMA Uncharacterized protein TM_0508 OS=Thermotog... 72.4 6e-11
sp|Q4J9D2|Y1252_SULAC Uncharacterized protein Saci_1252 OS=Sulfol... 67.8 7e-11
sp|Q96XY5|Y2383_SULTO Uncharacterized protein STK_23830 OS=Sulfur... 62.4 4e-09
sp|P0C6V7|R1AB_BEV Replicase polyprotein 1ab OS=Berne virus OX=11... 65.5 2e-08
sp|P0C6F3|R1A_BEV Replicase polyprotein 1a OS=Berne virus OX=1115... 65.5 2e-08
sp|A7MG20|YMDB_CROS8 O-acetyl-ADP-ribose deacetylase OS=Cronobact... 59.3 5e-08
sp|B5F961|YMDB_SALA4 O-acetyl-ADP-ribose deacetylase OS=Salmonell... 58.5 1e-07
sp|P0C6V8|R1AB_BRV1 Replicase polyprotein 1ab OS=Breda virus 1 OX... 62.8 1e-07
sp|P0C6F4|R1A_BRV1 Replicase polyprotein 1a OS=Breda virus 1 OX=3... 62.4 1e-07
sp|A8AI35|YMDB_CITK8 O-acetyl-ADP-ribose deacetylase OS=Citrobact... 58.2 1e-07
sp|P67341|YMDB_SALTY O-acetyl-ADP-ribose deacetylase OS=Salmonell... 56.6 5e-07
sp|P67342|YMDB_SALTI O-acetyl-ADP-ribose deacetylase OS=Salmonell... 56.6 5e-07
sp|B4T2X8|YMDB_SALNS O-acetyl-ADP-ribose deacetylase OS=Salmonell... 55.8 7e-07
sp|P0A8D6|YMDB_ECOLI O-acetyl-ADP-ribose deacetylase OS=Escherich... 55.1 1e-06
sp|P0A8D7|YMDB_ECOL6 O-acetyl-ADP-ribose deacetylase OS=Escherich... 55.1 1e-06
sp|P0A8D8|YMDB_ECO57 O-acetyl-ADP-ribose deacetylase OS=Escherich... 55.1 1e-06
sp|C9Y0V8|YMDB_CROTZ O-acetyl-ADP-ribose deacetylase OS=Cronobact... 54.7 2e-06
sp|B5RBF3|YMDB_SALG2 O-acetyl-ADP-ribose deacetylase OS=Salmonell... 54.3 2e-06
sp|D3RKJ0|YMDB_KLEVT O-acetyl-ADP-ribose deacetylase OS=Klebsiell... 53.9 4e-06
sp|B5XXK9|YMDB_KLEP3 O-acetyl-ADP-ribose deacetylase OS=Klebsiell... 53.9 4e-06
sp|Q0T5Z6|YMDB_SHIF8 O-acetyl-ADP-ribose deacetylase OS=Shigella ... 52.4 1e-05
sp|Q8CAS9|PARP9_MOUSE Protein mono-ADP-ribosyltransferase PARP9 O... 55.8 1e-05
sp|Q460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 ... 55.8 1e-05
sp|A4W960|YMDB_ENT38 O-acetyl-ADP-ribose deacetylase OS=Enterobac... 52.4 1e-05
sp|B7LT90|YMDB_ESCF3 O-acetyl-ADP-ribose deacetylase OS=Escherich... 52.4 1e-05
sp|P36327|POLN_EEVV3 Polyprotein P1234 OS=Venezuelan equine encep... 55.5 1e-05
sp|D2TT52|YMDB_CITRI O-acetyl-ADP-ribose deacetylase OS=Citrobact... 52.0 2e-05
sp|Q32E73|YMDB_SHIDS O-acetyl-ADP-ribose deacetylase OS=Shigella ... 51.6 2e-05
sp|P27282|POLN_EEVVT Polyprotein P1234 OS=Venezuelan equine encep... 55.1 2e-05
sp|Q8RHQ2|Y1951_FUSNN Uncharacterized protein FN1951 OS=Fusobacte... 51.6 2e-05
sp|P36328|POLN_EEVVP Polyprotein P1234 OS=Venezuelan equine encep... 54.7 2e-05
sp|D5CE05|YMDB_ENTCC O-acetyl-ADP-ribose deacetylase OS=Enterobac... 50.8 4e-05
sp|Q87JZ5|Y4103_VIBPA Macro domain-containing protein VPA0103 OS=... 48.5 2e-04
sp|Q8IXQ6|PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9 O... 51.6 2e-04
sp|Q8V294|POLN_EEVVC Polyprotein P1234 OS=Venezuelan equine encep... 51.6 2e-04
sp|Q8RB30|Y995_CALS4 Macro domain-containing protein TTE0995 OS=C... 47.8 5e-04
sp|Q2EMV9|PAR14_MOUSE Protein mono-ADP-ribosyltransferase PARP14 ... 50.4 5e-04
sp|Q8KAE4|Y2219_CHLTE Macro domain-containing protein CT2219 OS=C... 46.6 0.001
sp|Q8Y2K1|Y334_RALN1 Macro domain-containing protein RSc0334 OS=R... 46.2 0.001
sp|Q8EYT0|Y4133_LEPIN Macro domain-containing protein LA_4133 OS=... 46.2 0.001
sp|Q9WJC7|POLN_EEVVM Polyprotein P1234 OS=Venezuelan equine encep... 48.9 0.001
sp|Q72M93|Y3295_LEPIC Macro domain-containing protein LIC_13295 O... 46.2 0.001
sp|Q93SX7|Y189_ACISE Macro domain-containing protein OS=Acinetoba... 45.8 0.002
sp|E1SDF1|YMDB1_PANVC O-acetyl-ADP-ribose deacetylase 1 OS=Pantoe... 45.8 0.002
sp|Q8Q0F9|Y177_METMA Macro domain-containing protein MM_0177 OS=M... 45.1 0.004
sp|Q7MTZ7|MACRO_PORGI Macro domain-containing protein PG1779 OS=P... 43.1 0.014
sp|Q9ZBG3|Y6450_STRCO Macro domain-containing protein SCO6450 OS=... 43.1 0.015
sp|Q88SK6|Y3408_LACPL Macro domain-containing protein lp_3408 OS=... 42.7 0.020
sp|P13896|POLN_WEEV Polyprotein P1234 OS=Western equine encephali... 45.1 0.021
sp|O28751|Y1521_ARCFU ADP-ribose glycohydrolase AF_1521 OS=Archae... 43.1 0.022
sp|Q4QXJ8|POLN_EEEVF Polyprotein P1234 OS=Eastern equine encephal... 44.3 0.036
sp|O59182|Y1513_PYRHO Uncharacterized protein PH1513 OS=Pyrococcu... 42.0 0.041
sp|Q71W03|Y2748_LISMF Macro domain-containing protein LMOf2365_27... 41.2 0.073
sp|Q8Y3S3|Y2759_LISMO Macro domain-containing protein lmo2759 OS=... 41.2 0.080
sp|P05720|YCX1_AUXPY Uncharacterized 12.7 kDa protein in 16S-23S ... 39.7 0.083
sp|Q306W6|POLN_EEEV1 Polyprotein P1234 OS=Eastern equine encephal... 43.1 0.088
sp|Q926Y8|Y2902_LISIN Macro domain-containing protein lin2902 OS=... 40.8 0.093
sp|Q9V0Y3|Y656_PYRAB Uncharacterized protein PYRAB06560 OS=Pyroco... 40.8 0.10
sp|O40955|POLN_RUBVR Non-structural polyprotein p200 OS=Rubella v... 42.7 0.12
sp|Q9UTG3|YKEE_SCHPO Uncharacterized protein C1805.14 OS=Schizosa... 42.0 0.12
sp|Q8BCR0|POLN_RUBVN Non-structural polyprotein p200 OS=Rubella v... 42.4 0.13
sp|Q8TQD0|Y1614_METAC Macro domain-containing protein MA_1614 OS=... 40.0 0.20
sp|P13889|POLN_RUBVT Non-structural polyprotein p200 OS=Rubella v... 41.6 0.23
sp|Q9HXU7|Y3693_PSEAE Macro domain-containing protein PA3693 OS=P... 39.7 0.24
sp|Q9BQ69|MACD1_HUMAN ADP-ribose glycohydrolase MACROD1 OS=Homo s... 40.4 0.31
sp|Q8K4G6|MACD1_RAT ADP-ribose glycohydrolase MACROD1 (Fragment) ... 40.0 0.33
sp|Q8P5Z8|Y3184_XANCP Macro domain-containing protein XCC3184 OS=... 39.3 0.36
sp|Q9RUV0|PPDE_DEIRA Phosphatase/phosphodiesterase DR_1281 OS=Dei... 39.7 0.41
sp|Q306W8|POLN_EEEV8 Polyprotein P1234 OS=Eastern equine encephal... 40.8 0.45
sp|Q8PHB6|Y3343_XANAC Macro domain-containing protein XAC3343 OS=... 38.5 0.51
sp|Q97AU0|Y719_THEVO Uncharacterized protein TV0719 OS=Thermoplas... 38.9 0.52
sp|Q9HJ67|Y1105_THEAC Uncharacterized protein Ta1105 OS=Thermopla... 38.9 0.54
sp|P26627|R1AB_CVMJD Replicase polyprotein 1ab (Fragment) OS=Muri... 40.0 0.62
sp|Q6PAV8|MACD2_XENLA ADP-ribose glycohydrolase MACROD2 OS=Xenopu... 39.7 0.65
sp|Q9EYI6|Y189_STRNO Macro domain-containing protein in sno 5'reg... 38.1 0.76
sp|Q180E9|TIG_CLOD6 Trigger factor OS=Clostridioides difficile (s... 39.7 0.76
sp|Q922B1|MACD1_MOUSE ADP-ribose glycohydrolase MACROD1 OS=Mus mu... 38.9 0.88
sp|C4L602|RIMM_EXISA Ribosome maturation factor RimM OS=Exiguobac... 37.7 1.1
sp|Q7TZB9|Y1934_MYCBO Uncharacterized protein Mb1934c OS=Mycobact... 38.5 1.4
sp|P9WK29|Y1899_MYCTU Uncharacterized protein Rv1899c OS=Mycobact... 38.5 1.4
sp|P9WK28|Y1899_MYCTO Uncharacterized protein MT1950 OS=Mycobacte... 38.5 1.4
sp|Q985D2|Y7730_RHILO Macro domain-containing protein mll7730 OS=... 37.4 1.5
sp|Q2KHU5|MACD1_BOVIN ADP-ribose glycohydrolase MACROD1 OS=Bos ta... 38.1 1.8
sp|Q5TB80|CE162_HUMAN Centrosomal protein of 162 kDa OS=Homo sapi... 38.5 2.2
sp|E1PL40|YMDB2_PANVC O-acetyl-ADP-ribose deacetylase 2 OS=Pantoe... 36.6 2.3
sp|Q99IE5|POLN_RUBVV Non-structural polyprotein p200 OS=Rubella v... 38.1 2.6
sp|Q99IE7|POLN_RUBVO Non-structural polyprotein p200 OS=Rubella v... 37.7 3.2
sp|A1Z1Q3|MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 OS=Homo s... 37.0 4.1
sp|Q3ZX83|TIG_DEHMC Trigger factor OS=Dehalococcoides mccartyi (s... 36.6 5.4
sp|A9WSX9|RPOC_RENSM DNA-directed RNA polymerase subunit beta' OS... 37.0 6.2
sp|Q6X2U2|POLN_RUBVC Non-structural polyprotein p200 OS=Rubella v... 37.0 6.6
sp|B2GIK0|RPOC_KOCRD DNA-directed RNA polymerase subunit beta' OS... 36.6 7.7
sp|A1R8V3|RPOC_PAEAT DNA-directed RNA polymerase subunit beta' OS... 36.6 7.7
sp|Q8CDI7|CC150_MOUSE Coiled-coil domain-containing protein 150 O... 36.6 7.7
sp|Q3UYG8|MACD2_MOUSE ADP-ribose glycohydrolase MACROD2 OS=Mus mu... 36.2 8.2
sp|B8HD15|RPOC_PSECP DNA-directed RNA polymerase subunit beta' OS... 36.6 8.2
sp|A0JZ92|RPOC_ARTS2 DNA-directed RNA polymerase subunit beta' OS... 36.6 8.2
sp|Q9KHE2|Y189_STRGR Macro domain-containing protein in non 5'reg... 35.0 9.1
sp|P36517|RM04_YEAST Large ribosomal subunit protein uL29m OS=Sac... 35.8 9.2
sp|A7A1V9|RM04_YEAS7 Large ribosomal subunit protein uL29m OS=Sac... 35.8 9.2
sp|Q60A10|RL11_METCA Large ribosomal subunit protein uL11 OS=Meth... 34.3 9.5
sp|A6QAL0|MNME_SULNB tRNA modification GTPase MnmE OS=Sulfurovum ... 35.8 9.8
>sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute respiratory
syndrome coronavirus OX=694009 GN=1a PE=1 SV=1
Length=4382
Score = 9140 bits (23717), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4382/4382 (100%), Positives = 4382/4382 (100%), Gaps = 0/4382 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
Sbjct 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL
Sbjct 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY
Sbjct 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV
Sbjct 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
Sbjct 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC
Sbjct 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS
Sbjct 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
Query 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL
Sbjct 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
Query 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
Sbjct 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
Query 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP
Sbjct 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
Query 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT
Sbjct 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
Query 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR
Sbjct 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
Query 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
Sbjct 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
Query 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG
Sbjct 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
Query 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL
Sbjct 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
Query 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL
Sbjct 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
Query 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
Sbjct 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
Query 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
Sbjct 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC
Sbjct 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
Query 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK
Sbjct 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
Query 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
Sbjct 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
Query 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF
Sbjct 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
Query 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE
Sbjct 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
Query 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA
Sbjct 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
Query 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
Sbjct 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
Query 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL
Sbjct 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
Query 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA
Sbjct 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
Query 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW
Sbjct 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
Query 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
Sbjct 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
Query 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP
Sbjct 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
Query 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF
Sbjct 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
Query 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS
Sbjct 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
Query 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
Sbjct 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
Query 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE
Sbjct 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
Query 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA
Sbjct 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
Query 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG
Sbjct 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
Sbjct 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ
Sbjct 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
Query 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA
Sbjct 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
Query 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL
Sbjct 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
Query 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
Sbjct 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
Query 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ
Sbjct 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
Query 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ
Sbjct 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
Query 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR
Sbjct 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
Query 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
Sbjct 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
Query 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK
Sbjct 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
Query 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
Sbjct 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
Query 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
Sbjct 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
Query 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
Sbjct 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV
Sbjct 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
Query 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN
Sbjct 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
Query 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY
Sbjct 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
Query 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
Sbjct 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
Query 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG
Sbjct 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
Query 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS
Sbjct 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
Query 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND
Sbjct 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
Query 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
Sbjct 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
Query 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC
Sbjct 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP
Sbjct 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY
Sbjct 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
Sbjct 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF
Sbjct 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
Query 4381 AV 4382
AV
Sbjct 4381 AV 4382
>sp|P0C6X7|R1AB_SARS Replicase polyprotein 1ab OS=Severe acute
respiratory syndrome coronavirus OX=694009 GN=rep PE=1 SV=1
Length=7073
Score = 9103 bits (23620), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4378/4378 (100%), Positives = 4378/4378 (100%), Gaps = 0/4378 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
Sbjct 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL
Sbjct 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY
Sbjct 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV
Sbjct 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
Sbjct 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC
Sbjct 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS
Sbjct 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
Query 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL
Sbjct 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
Query 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
Sbjct 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
Query 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP
Sbjct 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
Query 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT
Sbjct 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
Query 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR
Sbjct 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
Query 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
Sbjct 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
Query 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG
Sbjct 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
Query 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL
Sbjct 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
Query 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL
Sbjct 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
Query 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
Sbjct 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
Query 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
Sbjct 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC
Sbjct 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
Query 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK
Sbjct 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
Query 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
Sbjct 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
Query 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF
Sbjct 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
Query 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE
Sbjct 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
Query 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA
Sbjct 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
Query 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
Sbjct 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
Query 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL
Sbjct 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
Query 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA
Sbjct 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
Query 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW
Sbjct 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
Query 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
Sbjct 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
Query 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP
Sbjct 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
Query 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF
Sbjct 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
Query 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS
Sbjct 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
Query 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
Sbjct 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
Query 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE
Sbjct 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
Query 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA
Sbjct 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
Query 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG
Sbjct 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
Sbjct 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ
Sbjct 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
Query 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA
Sbjct 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
Query 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL
Sbjct 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
Query 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
Sbjct 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
Query 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ
Sbjct 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
Query 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ
Sbjct 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
Query 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR
Sbjct 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
Query 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
Sbjct 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
Query 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK
Sbjct 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
Query 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
Sbjct 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
Query 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
Sbjct 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
Query 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
Sbjct 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV
Sbjct 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
Query 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN
Sbjct 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
Query 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY
Sbjct 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
Query 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
Sbjct 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
Query 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG
Sbjct 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
Query 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS
Sbjct 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
Query 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND
Sbjct 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
Query 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
Sbjct 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
Query 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC
Sbjct 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP
Sbjct 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY
Sbjct 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
Sbjct 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN
Sbjct 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
>sp|P0C6T7|R1A_BCRP3 Replicase polyprotein 1a OS=Bat coronavirus
Rp3/2004 OX=349344 GN=1a PE=3 SV=1
Length=4380
Score = 8851 bits (22967), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4232/4383 (97%), Positives = 4302/4383 (98%), Gaps = 4/4383 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLG+NEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLK+GTCG+VELEKGV
Sbjct 1 MESLVLGINEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKSGTCGIVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQ EQPYVFIKRSDA T+HGH+V ELVAE+DG+QYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQPEQPYVFIKRSDAQGTDHGHRVRELVAELDGVQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSG LRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGVLRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A+TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCRDH HEIAW
Sbjct 181 ALTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCRDHGHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGP TCGYL
Sbjct 301 RSVYPVATPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVSEGPNTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHS ADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSAADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDF LNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFQLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKP+KGAWNIGQ RSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPIKGAWNIGQHRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSIPDLQRAAVTILD ISEQSLRLVDAMVYTS+LLTNSVIIMAY
Sbjct 541 AGVIRSIFSRTLDAANHSIPDLQRAAVTILDSISEQSLRLVDAMVYTSNLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLL TTVEKLRPIF WIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLDTTVEKLRPIFAWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCF+DVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFVDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIK EQYCALSPGLLATNNVFRLKGGAP KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLEIKANEQYCALSPGLLATNNVFRLKGGAPTKGVTFGEDTVVEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDE-TCEHEYGTEDDYQG 959
WSVATFYLFDD+GEE SSRMYCSFYPPDEEE+ + EEEE+ E TCEHEYGTE+DY+G
Sbjct 901 WSVATFYLFDDSGEEKLSSRMYCSFYPPDEEEDCEEYEEEEEVSERTCEHEYGTEEDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS + ++VEE+EEEDWLDD E EPEPEP EEPVNQ TGYLKLTDNVAIK
Sbjct 961 LPLEFGASTDIIQVEEQEEEDWLDDAVEA---EPEPEPLHEEPVNQLTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIV+EAQ+ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD YIKLNGPLTVGG
Sbjct 1018 CVDIVEEAQNANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDHYIKLNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
LQ+CVQTVRTQVYI VNDK LYEQVVMDYLD+LKP+VEAPKQE P E K +EKSVVQ
Sbjct 1138 LQMCVQTVRTQVYIVVNDKVLYEQVVMDYLDSLKPKVEAPKQEVLPKAEYPKVDEKSVVQ 1197
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
K +DVKPKIKACIDEVTTTLEETKFLTNKLLLF DINGKLY DS+NMLRGEDMSFLEKDA
Sbjct 1198 KTIDVKPKIKACIDEVTTTLEETKFLTNKLLLFTDINGKLYQDSKNMLRGEDMSFLEKDA 1257
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVP++EYITTYPGQGCAGYTLEEAK
Sbjct 1258 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPINEYITTYPGQGCAGYTLEEAK 1317
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PNAKEEILGTVSWNLREMLAHAEETRKLMP+CMDVRAIMATIQ
Sbjct 1318 TALKKCKSAFYVLPSETPNAKEEILGTVSWNLREMLAHAEETRKLMPVCMDVRAIMATIQ 1377
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA
Sbjct 1378 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1437
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPA+VSVSSPDAVTTYNGYLTSSSKTSE+HFVETVSLAGSYRDWSYSGQRTEL
Sbjct 1438 RCMRSLKAPAIVSVSSPDAVTTYNGYLTSSSKTSEDHFVETVSLAGSYRDWSYSGQRTEL 1497
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRG+KIVYHTLESPV+FHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHTQ
Sbjct 1498 GVEFLKRGEKIVYHTLESPVKFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1557
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
LVDMSMTYGQQ GPTYL+GADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF
Sbjct 1558 LVDMSMTYGQQLGPTYLEGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1617
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1618 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRA 1677
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1678 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1737
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
TGVEAVMYMGTLSYDNLK GVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL
Sbjct 1738 TGVEAVMYMGTLSYDNLKMGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1797
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY
Sbjct 1798 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1857
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL+PTQPLPNASFDNFKLTCSNTKFADDLN
Sbjct 1858 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLIPTQPLPNASFDNFKLTCSNTKFADDLN 1917
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT
Sbjct 1918 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1977
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT EEVVENPTIQKEVI
Sbjct 1978 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTPEEVVENPTIQKEVI 2037
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPSDEGVKVTQEL HEDLMAAYVENTSITIKKPNELSLALGLKTI
Sbjct 2038 ECDVKTTEVVGNVILKPSDEGVKVTQELDHEDLMAAYVENTSITIKKPNELSLALGLKTI 2097
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHGIAAINSVPW KILAYVKPFLGQAA+TTSNCAKRL QR+FNNYMPYV TLLFQLCTF
Sbjct 2098 ATHGIAAINSVPWGKILAYVKPFLGQAAVTTSNCAKRLVQRMFNNYMPYVLTLLFQLCTF 2157
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRIRASLPTTIAKNSV+ + +LCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS
Sbjct 2158 TKSTNSRIRASLPTTIAKNSVRGIVRLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2217
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
LI VTAA GVLLSNFGAPSYC+GVRE YLNSSNVTTMDFCEGSFPCS+CLSGLDSLDSYP
Sbjct 2218 LIYVTAALGVLLSNFGAPSYCSGVRESYLNSSNVTTMDFCEGSFPCSVCLSGLDSLDSYP 2277
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLTILGLAAEW AYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS
Sbjct 2278 ALETIQVTISSYKLDLTILGLAAEWFFAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2337
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2338 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2397
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2398 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2457
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2458 PTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2517
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2518 FDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2577
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSA+RQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2578 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSASRQGVVDTDVDTKDVIECLKLSHHSD 2637
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVA+SHNVSLIWNVKDYMSLS
Sbjct 2638 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVARSHNVSLIWNVKDYMSLS 2697
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVST FK+MLKATLLCVL
Sbjct 2698 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTWFKIMLKATLLCVL 2757
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AALVCYIVMPVH LS+H GYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2758 AALVCYIVMPVHILSVHGGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2817
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2818 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2877
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDF+TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2878 IEYSDFSTSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2937
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPN YLEGSVRVVTTFDAEYCRHGTCERSE GICLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2938 QFPNAYLEGSVRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALPGVFCGVD 2997
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2998 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3057
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LFLMSFTILCL PAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3058 PLFLMSFTILCLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3117
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFFNNYLRKRV+FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT
Sbjct 3118 IYVFCISLKHFHWFFNNYLRKRVVFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3177
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3178 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3237
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI
Sbjct 3238 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3297
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3298 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3357
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT VHAGTDLEG
Sbjct 3358 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTEVHAGTDLEG 3417
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3418 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3477
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3478 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3537
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFK+IVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA+A
Sbjct 3538 CSGVTFQGKFKRIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAVA 3597
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3598 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3657
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS
Sbjct 3658 VMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3717
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3718 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3777
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3778 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3837
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3838 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3897
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK
Sbjct 3898 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3957
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFDR+AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3958 SLNVAKSEFDRNAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4017
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4018 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4077
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINM+NS NLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4078 DADSKIVQLSEINMENSSNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4137
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4138 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4197
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYL+FIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4198 PKVKYLHFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4257
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4258 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4317
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNG 4379
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLNG
Sbjct 4318 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLNG 4377
Query 4380 FAV 4382
FAV
Sbjct 4378 FAV 4380
>sp|P0C6W6|R1AB_BCRP3 Replicase polyprotein 1ab OS=Bat coronavirus
Rp3/2004 OX=349344 GN=rep PE=3 SV=1
Length=7071
Score = 8819 bits (22883), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4228/4379 (97%), Positives = 4298/4379 (98%), Gaps = 4/4379 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLG+NEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLK+GTCG+VELEKGV
Sbjct 1 MESLVLGINEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKSGTCGIVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQ EQPYVFIKRSDA T+HGH+V ELVAE+DG+QYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQPEQPYVFIKRSDAQGTDHGHRVRELVAELDGVQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSG LRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGVLRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A+TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCRDH HEIAW
Sbjct 181 ALTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCRDHGHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGP TCGYL
Sbjct 301 RSVYPVATPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVSEGPNTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHS ADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSAADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDF LNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFQLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKP+KGAWNIGQ RSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPIKGAWNIGQHRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSIPDLQRAAVTILD ISEQSLRLVDAMVYTS+LLTNSVIIMAY
Sbjct 541 AGVIRSIFSRTLDAANHSIPDLQRAAVTILDSISEQSLRLVDAMVYTSNLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLL TTVEKLRPIF WIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLDTTVEKLRPIFAWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCF+DVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFVDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIK EQYCALSPGLLATNNVFRLKGGAP KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLEIKANEQYCALSPGLLATNNVFRLKGGAPTKGVTFGEDTVVEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDE-TCEHEYGTEDDYQG 959
WSVATFYLFDD+GEE SSRMYCSFYPPDEEE+ + EEEE+ E TCEHEYGTE+DY+G
Sbjct 901 WSVATFYLFDDSGEEKLSSRMYCSFYPPDEEEDCEEYEEEEEVSERTCEHEYGTEEDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS + ++VEE+EEEDWLDD E EPEPEP EEPVNQ TGYLKLTDNVAIK
Sbjct 961 LPLEFGASTDIIQVEEQEEEDWLDDAVEA---EPEPEPLHEEPVNQLTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIV+EAQ+ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD YIKLNGPLTVGG
Sbjct 1018 CVDIVEEAQNANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDHYIKLNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
LQ+CVQTVRTQVYI VNDK LYEQVVMDYLD+LKP+VEAPKQE P E K +EKSVVQ
Sbjct 1138 LQMCVQTVRTQVYIVVNDKVLYEQVVMDYLDSLKPKVEAPKQEVLPKAEYPKVDEKSVVQ 1197
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
K +DVKPKIKACIDEVTTTLEETKFLTNKLLLF DINGKLY DS+NMLRGEDMSFLEKDA
Sbjct 1198 KTIDVKPKIKACIDEVTTTLEETKFLTNKLLLFTDINGKLYQDSKNMLRGEDMSFLEKDA 1257
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVP++EYITTYPGQGCAGYTLEEAK
Sbjct 1258 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPINEYITTYPGQGCAGYTLEEAK 1317
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PNAKEEILGTVSWNLREMLAHAEETRKLMP+CMDVRAIMATIQ
Sbjct 1318 TALKKCKSAFYVLPSETPNAKEEILGTVSWNLREMLAHAEETRKLMPVCMDVRAIMATIQ 1377
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA
Sbjct 1378 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1437
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPA+VSVSSPDAVTTYNGYLTSSSKTSE+HFVETVSLAGSYRDWSYSGQRTEL
Sbjct 1438 RCMRSLKAPAIVSVSSPDAVTTYNGYLTSSSKTSEDHFVETVSLAGSYRDWSYSGQRTEL 1497
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRG+KIVYHTLESPV+FHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHTQ
Sbjct 1498 GVEFLKRGEKIVYHTLESPVKFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1557
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
LVDMSMTYGQQ GPTYL+GADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF
Sbjct 1558 LVDMSMTYGQQLGPTYLEGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1617
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1618 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRA 1677
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1678 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1737
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
TGVEAVMYMGTLSYDNLK GVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL
Sbjct 1738 TGVEAVMYMGTLSYDNLKMGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1797
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY
Sbjct 1798 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1857
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL+PTQPLPNASFDNFKLTCSNTKFADDLN
Sbjct 1858 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLIPTQPLPNASFDNFKLTCSNTKFADDLN 1917
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT
Sbjct 1918 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1977
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT EEVVENPTIQKEVI
Sbjct 1978 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTPEEVVENPTIQKEVI 2037
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPSDEGVKVTQEL HEDLMAAYVENTSITIKKPNELSLALGLKTI
Sbjct 2038 ECDVKTTEVVGNVILKPSDEGVKVTQELDHEDLMAAYVENTSITIKKPNELSLALGLKTI 2097
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHGIAAINSVPW KILAYVKPFLGQAA+TTSNCAKRL QR+FNNYMPYV TLLFQLCTF
Sbjct 2098 ATHGIAAINSVPWGKILAYVKPFLGQAAVTTSNCAKRLVQRMFNNYMPYVLTLLFQLCTF 2157
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRIRASLPTTIAKNSV+ + +LCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS
Sbjct 2158 TKSTNSRIRASLPTTIAKNSVRGIVRLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2217
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
LI VTAA GVLLSNFGAPSYC+GVRE YLNSSNVTTMDFCEGSFPCS+CLSGLDSLDSYP
Sbjct 2218 LIYVTAALGVLLSNFGAPSYCSGVRESYLNSSNVTTMDFCEGSFPCSVCLSGLDSLDSYP 2277
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLTILGLAAEW AYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS
Sbjct 2278 ALETIQVTISSYKLDLTILGLAAEWFFAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2337
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2338 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2397
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2398 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2457
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2458 PTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2517
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2518 FDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2577
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSA+RQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2578 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSASRQGVVDTDVDTKDVIECLKLSHHSD 2637
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVA+SHNVSLIWNVKDYMSLS
Sbjct 2638 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVARSHNVSLIWNVKDYMSLS 2697
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVST FK+MLKATLLCVL
Sbjct 2698 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTWFKIMLKATLLCVL 2757
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AALVCYIVMPVH LS+H GYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2758 AALVCYIVMPVHILSVHGGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2817
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2818 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2877
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDF+TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2878 IEYSDFSTSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2937
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPN YLEGSVRVVTTFDAEYCRHGTCERSE GICLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2938 QFPNAYLEGSVRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALPGVFCGVD 2997
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2998 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3057
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LFLMSFTILCL PAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3058 PLFLMSFTILCLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3117
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFFNNYLRKRV+FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT
Sbjct 3118 IYVFCISLKHFHWFFNNYLRKRVVFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3177
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3178 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3237
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI
Sbjct 3238 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3297
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3298 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3357
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT VHAGTDLEG
Sbjct 3358 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTEVHAGTDLEG 3417
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3418 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3477
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3478 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3537
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFK+IVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA+A
Sbjct 3538 CSGVTFQGKFKRIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAVA 3597
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3598 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3657
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS
Sbjct 3658 VMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3717
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3718 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3777
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3778 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3837
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3838 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3897
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK
Sbjct 3898 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3957
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFDR+AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3958 SLNVAKSEFDRNAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4017
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4018 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4077
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINM+NS NLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4078 DADSKIVQLSEINMENSSNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4137
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4138 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4197
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYL+FIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4198 PKVKYLHFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4257
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4258 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4317
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLN
Sbjct 4318 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLN 4376
>sp|P0C6F8|R1A_BCHK3 Replicase polyprotein 1a OS=Bat coronavirus
HKU3 OX=442736 GN=1a PE=3 SV=1
Length=4376
Score = 8575 bits (22250), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4117/4383 (94%), Positives = 4255/4383 (97%), Gaps = 8/4383 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAE+DGIQ+GRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAELDGIQFGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
VTRYVDNNFCGPDGYPL+CIKDFLARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 VVTRYVDNNFCGPDGYPLECIKDFLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVF+YVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFSYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITG+NVETLNEDLLEIL+RERVNINIVGDF NEEVAIILASF
Sbjct 421 AYWVPRASANIGANHTGITGENVETLNEDLLEILNRERVNINIVGDFRFNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAS SAFI+T+K LDYKSFK IVESCGNYKVT GKPV GAWNIGQQRS+LTPLCGFPSQA
Sbjct 481 SASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGKPVTGAWNIGQQRSILTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSI DLQRAAVT LDGISEQSLRLVDAMVYTSDLLTNSV++MAY
Sbjct 541 AGVIRSIFSRTLDAANHSILDLQRAAVTTLDGISEQSLRLVDAMVYTSDLLTNSVVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQT QWLSN+LGT V+KL+P+F W+EAKLSAGVEFL+DAWEILKFLITGVFD++
Sbjct 601 VTGGLVQQTMQWLSNMLGTAVDKLKPVFTWVEAKLSAGVEFLRDAWEILKFLITGVFDVI 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVA+DNIK+CVK F+ VVNKALEMC+DQVTIAG KLR+LNLGEVFIAQS+GLYRQC
Sbjct 661 KGQIQVATDNIKECVKIFLGVVNKALEMCLDQVTIAGTKLRALNLGEVFIAQSRGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGD+HDTVLTSEEVVLK+GELEALETP+DSFT+GA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVLKSGELEALETPIDSFTSGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLE+++KEQYCALSPGLLATNNVFRLKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLELENKEQYCALSPGLLATNNVFRLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELD RVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLT MGIDLDE
Sbjct 841 KITFELDVRVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTPMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEE E EYGTEDDY+GL
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEECEDEEETCEH---EYGTEDDYKGL 957
Query 961 PLEFGASAETVRVEEEEEE-DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
PLEFGAS ET VEEEEEE DWLDD E PEEPVNQF GYLKLTDNVAIK
Sbjct 958 PLEFGASTETPHVEEEEEEEDWLDDAIEAEPEPEP---LPEEPVNQFVGYLKLTDNVAIK 1014
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
C+DIVKEAQSA P VIVNAAN HLKHGGGVAGALNKATNGAMQ ESD+YI+ NGPLTVGG
Sbjct 1015 CIDIVKEAQSAKPTVIVNAANTHLKHGGGVAGALNKATNGAMQNESDEYIRQNGPLTVGG 1074
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLA+KCLHVVGPNLNAGED+QLLK AYENFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1075 SCLLSGHNLAEKCLHVVGPNLNAGEDVQLLKRAYENFNSQDVLLAPLLSAGIFGAKPLQS 1134
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
L++CV+ VRTQVY+AVNDK+LY+Q+V+DYLD+LKP+VE+P +EE P E+ K + V +
Sbjct 1135 LKMCVEIVRTQVYLAVNDKSLYDQIVLDYLDSLKPKVESPNKEEEPKLEEPKAVQ-PVAE 1193
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLY DSQNMLRGEDMSFLEKDA
Sbjct 1194 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYQDSQNMLRGEDMSFLEKDA 1253
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PY+VGDVITSGDITCV+IP+KK+GGTTEML+RALK+VPV EYITTYPGQGCAGYTLEEAK
Sbjct 1254 PYIVGDVITSGDITCVIIPAKKSGGTTEMLARALKEVPVAEYITTYPGQGCAGYTLEEAK 1313
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PN KEE+LGTVSWNLREMLAHAEETRKLMPIC+DVRAIMATIQ
Sbjct 1314 TALKKCKSAFYVLPSETPNEKEEVLGTVSWNLREMLAHAEETRKLMPICLDVRAIMATIQ 1373
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHG NLEEAA
Sbjct 1374 RKYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGLNLEEAA 1433
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPAVVSVSSPDAVT YNGYLTSSSKT EE+FVET SLAGSYRDWSYSGQRTEL
Sbjct 1434 RCMRSLKAPAVVSVSSPDAVTAYNGYLTSSSKTPEEYFVETTSLAGSYRDWSYSGQRTEL 1493
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRGDKIVYHT SP+EFHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHT
Sbjct 1494 GVEFLKRGDKIVYHTTGSPIEFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTH 1553
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
+VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHT+DESF
Sbjct 1554 IVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTIDESF 1613
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1614 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQVEVKFNAPALQEAYYRA 1673
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1674 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1733
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
GVEAVMYMGTLSYD LKTGVSIPCVCGR+ATQYLVQQESSFVMMSAPPAEYKLQQG FL
Sbjct 1734 KGVEAVMYMGTLSYDELKTGVSIPCVCGRNATQYLVQQESSFVMMSAPPAEYKLQQGAFL 1793
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYR+DGAHLTKMSEYKGPVTDVFYKETSYTT IKPVSY
Sbjct 1794 CANEYTGNYQCGHYTHITAKETLYRVDGAHLTKMSEYKGPVTDVFYKETSYTTAIKPVSY 1853
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKK NAYYTEQPIDLVPTQP+PNASFDNFKLTCSNTKFADDLN
Sbjct 1854 KLDGVTYTEIEPKLDGYYKKGNAYYTEQPIDLVPTQPMPNASFDNFKLTCSNTKFADDLN 1913
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGF KPASREL+VTFFPDLNGDVVAIDYRHYS SFKKGAKL+HKPI+WHINQ T KTT
Sbjct 1914 QMTGFKKPASRELTVTFFPDLNGDVVAIDYRHYSTSFKKGAKLVHKPILWHINQTTNKTT 1973
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
+KPN WCLRCLWSTKPVDTSNSFEVL VEDTQGMDNLACESQ TSEEVVENPT+QKE+I
Sbjct 1974 YKPNIWCLRCLWSTKPVDTSNSFEVLVVEDTQGMDNLACESQTTTSEEVVENPTVQKEII 2033
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNELSLALGLKT+
Sbjct 2034 ECDVKTTEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNELSLALGLKTL 2093
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHG AAINSVPWSKILAYVKPFLGQ A+ TSNC K+ QRVF+NYMPYV TLLFQLCTF
Sbjct 2094 ATHGAAAINSVPWSKILAYVKPFLGQTAVITSNCIKKCVQRVFSNYMPYVITLLFQLCTF 2153
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRI+ASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTI MWLLLLSICLGS
Sbjct 2154 TKSTNSRIKASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIVMWLLLLSICLGS 2213
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
L VTA GV LS+ G PSYC+GVRELY+NSSNVTTMDFC+G FPCS+CLSGLDSLDSYP
Sbjct 2214 LTYVTAVLGVCLSSLGVPSYCDGVRELYINSSNVTTMDFCQGYFPCSVCLSGLDSLDSYP 2273
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLT LGLAAEW+LAYMLFTKFFYLLGLSAIMQ FFGYFASHFISNS
Sbjct 2274 ALETIQVTISSYKLDLTFLGLAAEWLLAYMLFTKFFYLLGLSAIMQAFFGYFASHFISNS 2333
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYY+WKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2334 WLMWFIISIVQMAPVSAMVRMYIFFASFYYVWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2393
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNG+KRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2394 CTTIVNGVKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2453
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQS+Y+VDSV VKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2454 PTDQSAYVVDSVTVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2513
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKC+ESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2514 FDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2573
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2574 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2633
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
+EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSL+WNVKDYMSLS
Sbjct 2634 IEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLVWNVKDYMSLS 2693
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGK+VST FKL+LK TLLCVL
Sbjct 2694 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKVVSTWFKLLLKVTLLCVL 2753
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AAL CY++MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2754 AALFCYVIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2813
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSY+NDK+CPVVAAIITREIGFIVPGLPGTVLRA+NGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2814 GSYRNDKNCPVVAAIITREIGFIVPGLPGTVLRALNGDFLHFLPRVFSAVGNICYTPSKL 2873
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2874 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2933
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVG+CLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2934 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVD 2993
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2994 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3053
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3054 LLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3113
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFF+NYL+KRVMFNGVTFSTFEEAALCTFLLNKEMYL+LRSETLLPLT
Sbjct 3114 IYVFCISLKHFHWFFSNYLKKRVMFNGVTFSTFEEAALCTFLLNKEMYLRLRSETLLPLT 3173
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3174 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3233
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV+CTAEDMLNPNY+DLLI
Sbjct 3234 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVVCTAEDMLNPNYDDLLI 3293
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3294 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3353
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG
Sbjct 3354 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3413
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3414 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3473
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3474 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3533
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPF LGIMA+A
Sbjct 3534 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFALGIMAVA 3593
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3594 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3653
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAISMWALVISVTS
Sbjct 3654 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAISMWALVISVTS 3713
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3714 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3773
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3774 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3833
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3834 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3893
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV+NGDSEVVLKKLKK
Sbjct 3894 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVSNGDSEVVLKKLKK 3953
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFD DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3954 SLNVAKSEFDHDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4013
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4014 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4073
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4074 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4133
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNN+KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4134 CTDDNALAYYNNAKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4193
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4194 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4253
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4254 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4313
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNG 4379
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLNG
Sbjct 4314 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLNG 4373
Query 4380 FAV 4382
FAV
Sbjct 4374 FAV 4376
>sp|P0C6W2|R1AB_BCHK3 Replicase polyprotein 1ab OS=Bat coronavirus
HKU3 OX=442736 GN=rep PE=3 SV=1
Length=7067
Score = 8550 bits (22185), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4113/4379 (94%), Positives = 4251/4379 (97%), Gaps = 8/4379 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAE+DGIQ+GRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAELDGIQFGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
VTRYVDNNFCGPDGYPL+CIKDFLARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 VVTRYVDNNFCGPDGYPLECIKDFLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVF+YVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFSYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITG+NVETLNEDLLEIL+RERVNINIVGDF NEEVAIILASF
Sbjct 421 AYWVPRASANIGANHTGITGENVETLNEDLLEILNRERVNINIVGDFRFNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAS SAFI+T+K LDYKSFK IVESCGNYKVT GKPV GAWNIGQQRS+LTPLCGFPSQA
Sbjct 481 SASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGKPVTGAWNIGQQRSILTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSI DLQRAAVT LDGISEQSLRLVDAMVYTSDLLTNSV++MAY
Sbjct 541 AGVIRSIFSRTLDAANHSILDLQRAAVTTLDGISEQSLRLVDAMVYTSDLLTNSVVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQT QWLSN+LGT V+KL+P+F W+EAKLSAGVEFL+DAWEILKFLITGVFD++
Sbjct 601 VTGGLVQQTMQWLSNMLGTAVDKLKPVFTWVEAKLSAGVEFLRDAWEILKFLITGVFDVI 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVA+DNIK+CVK F+ VVNKALEMC+DQVTIAG KLR+LNLGEVFIAQS+GLYRQC
Sbjct 661 KGQIQVATDNIKECVKIFLGVVNKALEMCLDQVTIAGTKLRALNLGEVFIAQSRGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGD+HDTVLTSEEVVLK+GELEALETP+DSFT+GA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVLKSGELEALETPIDSFTSGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLE+++KEQYCALSPGLLATNNVFRLKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLELENKEQYCALSPGLLATNNVFRLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELD RVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLT MGIDLDE
Sbjct 841 KITFELDVRVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTPMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEE E EYGTEDDY+GL
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEECEDEEETCEH---EYGTEDDYKGL 957
Query 961 PLEFGASAETVRVEEEEEE-DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
PLEFGAS ET VEEEEEE DWLDD E PEEPVNQF GYLKLTDNVAIK
Sbjct 958 PLEFGASTETPHVEEEEEEEDWLDDAIEAEPEPEP---LPEEPVNQFVGYLKLTDNVAIK 1014
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
C+DIVKEAQSA P VIVNAAN HLKHGGGVAGALNKATNGAMQ ESD+YI+ NGPLTVGG
Sbjct 1015 CIDIVKEAQSAKPTVIVNAANTHLKHGGGVAGALNKATNGAMQNESDEYIRQNGPLTVGG 1074
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLA+KCLHVVGPNLNAGED+QLLK AYENFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1075 SCLLSGHNLAEKCLHVVGPNLNAGEDVQLLKRAYENFNSQDVLLAPLLSAGIFGAKPLQS 1134
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
L++CV+ VRTQVY+AVNDK+LY+Q+V+DYLD+LKP+VE+P +EE P E+ K + V +
Sbjct 1135 LKMCVEIVRTQVYLAVNDKSLYDQIVLDYLDSLKPKVESPNKEEEPKLEEPKAVQ-PVAE 1193
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLY DSQNMLRGEDMSFLEKDA
Sbjct 1194 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYQDSQNMLRGEDMSFLEKDA 1253
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PY+VGDVITSGDITCV+IP+KK+GGTTEML+RALK+VPV EYITTYPGQGCAGYTLEEAK
Sbjct 1254 PYIVGDVITSGDITCVIIPAKKSGGTTEMLARALKEVPVAEYITTYPGQGCAGYTLEEAK 1313
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PN KEE+LGTVSWNLREMLAHAEETRKLMPIC+DVRAIMATIQ
Sbjct 1314 TALKKCKSAFYVLPSETPNEKEEVLGTVSWNLREMLAHAEETRKLMPICLDVRAIMATIQ 1373
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHG NLEEAA
Sbjct 1374 RKYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGLNLEEAA 1433
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPAVVSVSSPDAVT YNGYLTSSSKT EE+FVET SLAGSYRDWSYSGQRTEL
Sbjct 1434 RCMRSLKAPAVVSVSSPDAVTAYNGYLTSSSKTPEEYFVETTSLAGSYRDWSYSGQRTEL 1493
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRGDKIVYHT SP+EFHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHT
Sbjct 1494 GVEFLKRGDKIVYHTTGSPIEFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTH 1553
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
+VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHT+DESF
Sbjct 1554 IVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTIDESF 1613
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1614 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQVEVKFNAPALQEAYYRA 1673
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1674 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1733
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
GVEAVMYMGTLSYD LKTGVSIPCVCGR+ATQYLVQQESSFVMMSAPPAEYKLQQG FL
Sbjct 1734 KGVEAVMYMGTLSYDELKTGVSIPCVCGRNATQYLVQQESSFVMMSAPPAEYKLQQGAFL 1793
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYR+DGAHLTKMSEYKGPVTDVFYKETSYTT IKPVSY
Sbjct 1794 CANEYTGNYQCGHYTHITAKETLYRVDGAHLTKMSEYKGPVTDVFYKETSYTTAIKPVSY 1853
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKK NAYYTEQPIDLVPTQP+PNASFDNFKLTCSNTKFADDLN
Sbjct 1854 KLDGVTYTEIEPKLDGYYKKGNAYYTEQPIDLVPTQPMPNASFDNFKLTCSNTKFADDLN 1913
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGF KPASREL+VTFFPDLNGDVVAIDYRHYS SFKKGAKL+HKPI+WHINQ T KTT
Sbjct 1914 QMTGFKKPASRELTVTFFPDLNGDVVAIDYRHYSTSFKKGAKLVHKPILWHINQTTNKTT 1973
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
+KPN WCLRCLWSTKPVDTSNSFEVL VEDTQGMDNLACESQ TSEEVVENPT+QKE+I
Sbjct 1974 YKPNIWCLRCLWSTKPVDTSNSFEVLVVEDTQGMDNLACESQTTTSEEVVENPTVQKEII 2033
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNELSLALGLKT+
Sbjct 2034 ECDVKTTEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNELSLALGLKTL 2093
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHG AAINSVPWSKILAYVKPFLGQ A+ TSNC K+ QRVF+NYMPYV TLLFQLCTF
Sbjct 2094 ATHGAAAINSVPWSKILAYVKPFLGQTAVITSNCIKKCVQRVFSNYMPYVITLLFQLCTF 2153
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRI+ASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTI MWLLLLSICLGS
Sbjct 2154 TKSTNSRIKASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIVMWLLLLSICLGS 2213
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
L VTA GV LS+ G PSYC+GVRELY+NSSNVTTMDFC+G FPCS+CLSGLDSLDSYP
Sbjct 2214 LTYVTAVLGVCLSSLGVPSYCDGVRELYINSSNVTTMDFCQGYFPCSVCLSGLDSLDSYP 2273
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLT LGLAAEW+LAYMLFTKFFYLLGLSAIMQ FFGYFASHFISNS
Sbjct 2274 ALETIQVTISSYKLDLTFLGLAAEWLLAYMLFTKFFYLLGLSAIMQAFFGYFASHFISNS 2333
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYY+WKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2334 WLMWFIISIVQMAPVSAMVRMYIFFASFYYVWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2393
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNG+KRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2394 CTTIVNGVKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2453
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQS+Y+VDSV VKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2454 PTDQSAYVVDSVTVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2513
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKC+ESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2514 FDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2573
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2574 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2633
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
+EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSL+WNVKDYMSLS
Sbjct 2634 IEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLVWNVKDYMSLS 2693
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGK+VST FKL+LK TLLCVL
Sbjct 2694 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKVVSTWFKLLLKVTLLCVL 2753
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AAL CY++MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2754 AALFCYVIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2813
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSY+NDK+CPVVAAIITREIGFIVPGLPGTVLRA+NGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2814 GSYRNDKNCPVVAAIITREIGFIVPGLPGTVLRALNGDFLHFLPRVFSAVGNICYTPSKL 2873
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2874 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2933
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVG+CLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2934 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVD 2993
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2994 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3053
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3054 LLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3113
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFF+NYL+KRVMFNGVTFSTFEEAALCTFLLNKEMYL+LRSETLLPLT
Sbjct 3114 IYVFCISLKHFHWFFSNYLKKRVMFNGVTFSTFEEAALCTFLLNKEMYLRLRSETLLPLT 3173
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3174 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3233
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV+CTAEDMLNPNY+DLLI
Sbjct 3234 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVVCTAEDMLNPNYDDLLI 3293
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3294 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3353
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG
Sbjct 3354 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3413
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3414 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3473
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3474 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3533
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPF LGIMA+A
Sbjct 3534 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFALGIMAVA 3593
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3594 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3653
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAISMWALVISVTS
Sbjct 3654 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAISMWALVISVTS 3713
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3714 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3773
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3774 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3833
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3834 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3893
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV+NGDSEVVLKKLKK
Sbjct 3894 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVSNGDSEVVLKKLKK 3953
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFD DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3954 SLNVAKSEFDHDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4013
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4014 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4073
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4074 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4133
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNN+KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4134 CTDDNALAYYNNAKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4193
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4194 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4253
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4254 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4313
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLN
Sbjct 4314 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLN 4372
>sp|P0C6F5|R1A_BC279 Replicase polyprotein 1a OS=Bat coronavirus
279/2005 OX=389167 GN=1a PE=3 SV=1
Length=4388
Score = 8523 bits (22116), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4097/4393 (93%), Positives = 4241/4393 (97%), Gaps = 16/4393 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESL LGV+EKTHVQLSLPVLQVRDVLVRGFGDSVEEAL+EAREHLKNGTCGLVELEKGV
Sbjct 1 MESLALGVSEKTHVQLSLPVLQVRDVLVRGFGDSVEEALAEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA TNHG+KVVELVAE+DGIQYGRSG TLGVLVPHVGETP+AYRN
Sbjct 61 LPQLEQPYVFIKRSDAQGTNHGYKVVELVAELDGIQYGRSGTTLGVLVPHVGETPVAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLG ELGTDPIEDYEQNWNTKHG G LREL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGVELGTDPIEDYEQNWNTKHGGGVLRELIRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 AFTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYE QTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYERQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVFAYVGCYNKR
Sbjct 361 PANAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITGDNVETLNEDL+EIL+R+RVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASANIGASHTGITGDNVETLNEDLMEILNRDRVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAST AF+DT+K LDYK+FK IVESCGN+KVT+G+ KGAWNIGQ++S+LTPL GFPSQA
Sbjct 481 SASTCAFVDTVKGLDYKTFKDIVESCGNFKVTRGRAKKGAWNIGQEKSILTPLYGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF R LD ANHSIPDLQRAA+TILDGISEQSLRL+DAMVYTSDLLTNSVI+MAY
Sbjct 541 AGVIRSIFTRALDTANHSIPDLQRAAITILDGISEQSLRLIDAMVYTSDLLTNSVIVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQ +QWLSN+LGTTV+KL+P+F W+EAKLSAG+EFL+DAWEILKFL+TGVFDIV
Sbjct 601 VTGGLVQQITQWLSNMLGTTVDKLKPVFTWVEAKLSAGIEFLRDAWEILKFLVTGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDN+K+CVK F+DV+NKALEMCIDQV IAGAKLR+LNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNLKECVKAFLDVLNKALEMCIDQVIIAGAKLRTLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPL+APKEVTF EGDSHDTV TSEEVVLKNGELEALETPVDSFTNGA++G
Sbjct 721 IRGKEQLQLLMPLRAPKEVTFFEGDSHDTVFTSEEVVLKNGELEALETPVDSFTNGAVIG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLE+KDKEQYCALSPGLLATNNVF LKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCVNGLMLLELKDKEQYCALSPGLLATNNVFSLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 KITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE-HEYGTEDDYQG 959
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEEI E HEYGTEDDY+G
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEEYEDEEEIPEETCEHEYGTEDDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS E +++ +EE+ D E +PEPEP PEEPVNQFTGYLKLTDNVAIK
Sbjct 961 LPLEFGASTE---IQQVDEEEEEDWLEEAIAAKPEPEPLPEEPVNQFTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIVKEAQ A P VIVNAAN+HLKHGGGVAGALNKATNGAMQ+ESDDYIK NGPLTVGG
Sbjct 1018 CVDIVKEAQHAKPTVIVNAANVHLKHGGGVAGALNKATNGAMQQESDDYIKKNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKC+HVVGPNLNAGED+QLLKAAY NFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCMHVVGPNLNAGEDVQLLKAAYANFNSQDVLLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE----------EPPNTED 1189
L++CV+TVRTQVY AVND+ LY+ VV+ YLD+LKP+VE P QE E E+
Sbjct 1138 LKMCVETVRTQVYFAVNDQDLYDHVVLGYLDSLKPKVETPTQENLELKEQPAVETLTQEN 1197
Query 1190 SKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRG 1249
+ EE V++KPVDVK KA I+EV T+LEETKFLT++LLLFADINGKLY DSQNMLRG
Sbjct 1198 LELEELPVIEKPVDVK--FKARIEEVNTSLEETKFLTSRLLLFADINGKLYQDSQNMLRG 1255
Query 1250 EDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQG 1309
EDM FLEKDAPY+VGDVI+SGDITCV+IP+KKAGGTTEML++ALKKVPV EYITTYPGQG
Sbjct 1256 EDMFFLEKDAPYIVGDVISSGDITCVIIPAKKAGGTTEMLAKALKKVPVSEYITTYPGQG 1315
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICM 1369
CAGYTLEEAKTAL+KCKS FYVLPS+ PN KEEILGTVSWNLREMLAHAEETRKLM ICM
Sbjct 1316 CAGYTLEEAKTALRKCKSVFYVLPSKTPNDKEEILGTVSWNLREMLAHAEETRKLMLICM 1375
Query 1370 DVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYV 1429
DV+A+M+TI R+YKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLN LNEPLVTMPIGYV
Sbjct 1376 DVKALMSTIHRRYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNLLNEPLVTMPIGYV 1435
Query 1430 THGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRD 1489
THG NLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF+ETVSLAG YRD
Sbjct 1436 THGLNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFIETVSLAGMYRD 1495
Query 1490 WSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFT 1549
WSYSGQRTELGVEFLKRGDK+VYHT+ SP++FHLDGEVL LDKLKSLLSLREV+TIKVFT
Sbjct 1496 WSYSGQRTELGVEFLKRGDKVVYHTVGSPIQFHLDGEVLLLDKLKSLLSLREVRTIKVFT 1555
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF 1609
TVDNTNLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH HEGKTFFVLPSDDTLRSEAF
Sbjct 1556 TVDNTNLHTQIVDMSMTYGQQFGPTYLDGADVTKIKPHAKHEGKTFFVLPSDDTLRSEAF 1615
Query 1610 EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNA 1669
EYYHTLDESFLGRYMSALNHTKKWKFPQ+GGLTSIKWADNNCYLSSVLLALQQ+EVKFNA
Sbjct 1616 EYYHTLDESFLGRYMSALNHTKKWKFPQIGGLTSIKWADNNCYLSSVLLALQQIEVKFNA 1675
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1729
PALQEAYYRARAGDAANFCALILAYSN+TVGELGDVRETMTHLLQHANLESAKRVLNVVC
Sbjct 1676 PALQEAYYRARAGDAANFCALILAYSNRTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1735
Query 1730 KHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA 1789
K CGQK+TTLTGVEAVMYMGTLSY+ LKTGV+IPC+CGRDATQYLVQQESSFVMMSAPP+
Sbjct 1736 KTCGQKSTTLTGVEAVMYMGTLSYEELKTGVTIPCICGRDATQYLVQQESSFVMMSAPPS 1795
Query 1790 EYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
EY LQQG FLCANEYTG+YQCGHYTH+T KETLYRIDGA+LTKMSEYKGPVTDVFYKE S
Sbjct 1796 EYTLQQGAFLCANEYTGSYQCGHYTHVTVKETLYRIDGAYLTKMSEYKGPVTDVFYKEIS 1855
Query 1850 YTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1909
YTTTIKPVSYKLDGV YTEI+PKLD YYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC
Sbjct 1856 YTTTIKPVSYKLDGVIYTEIQPKLDEYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1915
Query 1910 SNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW 1969
SNTKFADDLNQMTGF KPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPI+W
Sbjct 1916 SNTKFADDLNQMTGFKKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW 1975
Query 1970 HINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVV 2029
HINQ T KTT+KPNTWCLRCLWSTKPV+TSNSFEVL VEDTQGMDNLACESQ PTSEEVV
Sbjct 1976 HINQTTNKTTYKPNTWCLRCLWSTKPVETSNSFEVLEVEDTQGMDNLACESQTPTSEEVV 2035
Query 2030 ENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
ENPTIQKEVIECDVKT EVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNE
Sbjct 2036 ENPTIQKEVIECDVKTIEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNE 2095
Query 2090 LSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYV 2149
LSLALGL+T+ATHG AAINSVPWSKILAYVKPFLGQAA+TT+NC KR QRVFNNYMPYV
Sbjct 2096 LSLALGLRTLATHGAAAINSVPWSKILAYVKPFLGQAAVTTTNCIKRCVQRVFNNYMPYV 2155
Query 2150 FTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMW 2209
TLLFQLCTFT+STNSRIRASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTIAMW
Sbjct 2156 ITLLFQLCTFTRSTNSRIRASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIAMW 2215
Query 2210 LLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICL 2269
LLLLSICLGSLI VTAAFGVLLSN G PSYC+GVRE Y+NSSNVTTMDFCEGSF CS+CL
Sbjct 2216 LLLLSICLGSLIYVTAAFGVLLSNLGIPSYCDGVRESYVNSSNVTTMDFCEGSFLCSVCL 2275
Query 2270 SGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFG 2329
+GLDSLDSYPALETIQVTISSYKLDLT LGLAAEW LAYMLFTKFFYLLGLSAIMQVFFG
Sbjct 2276 NGLDSLDSYPALETIQVTISSYKLDLTSLGLAAEWFLAYMLFTKFFYLLGLSAIMQVFFG 2335
Query 2330 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMC 2389
YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFA YY+WKSYVHIMDGCTSSTCMMC
Sbjct 2336 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFAFCYYVWKSYVHIMDGCTSSTCMMC 2395
Query 2390 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARD 2449
YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARD
Sbjct 2396 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARD 2455
Query 2450 LSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2509
LSLQFKRPINPTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT
Sbjct 2456 LSLQFKRPINPTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2515
Query 2510 KGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2569
KGSLPINVIVFDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD
Sbjct 2516 KGSLPINVIVFDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2575
Query 2570 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2629
AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI
Sbjct 2576 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2635
Query 2630 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2689
ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI
Sbjct 2636 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2695
Query 2690 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKL 2749
WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN ITTKISLKGGKIVST FKL
Sbjct 2696 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNAITTKISLKGGKIVSTWFKL 2755
Query 2750 MLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
MLKATLLCVLAAL CYI+MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI++TDDCFANKHA
Sbjct 2756 MLKATLLCVLAALFCYIIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIMATDDCFANKHA 2815
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
GFD+WFSQRGGSY+NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV
Sbjct 2816 GFDSWFSQRGGSYRNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2875
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT
Sbjct 2876 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2935
Query 2930 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYR 2989
RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE G+CLSTSGRWVLNNEHYR
Sbjct 2936 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEAGVCLSTSGRWVLNNEHYR 2995
Query 2990 ALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFG 3049
AL GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FG
Sbjct 2996 ALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFG 3055
Query 3050 EYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMF 3109
EYNHVVAANALLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMF
Sbjct 3056 EYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMF 3115
Query 3110 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3169
SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK
Sbjct 3116 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3175
Query 3170 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3229
LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP
Sbjct 3176 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3235
Query 3230 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3289
PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM
Sbjct 3236 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3295
Query 3290 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3349
LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG
Sbjct 3296 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3355
Query 3350 QTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3409
QTFSVLACYNGSPSGVYQCAMRPN+TIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT
Sbjct 3356 QTFSVLACYNGSPSGVYQCAMRPNYTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3415
Query 3410 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3469
GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND
Sbjct 3416 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3475
Query 3470 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3529
FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED
Sbjct 3476 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3535
Query 3530 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3589
EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL
Sbjct 3536 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3595
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT
Sbjct 3596 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3655
Query 3650 SLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAIS 3709
SLSGYRLKDCVMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAIS
Sbjct 3656 SLSGYRLKDCVMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAIS 3715
Query 3710 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3769
MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC
Sbjct 3716 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3775
Query 3770 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3829
YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC
Sbjct 3776 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3835
Query 3830 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3889
IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV
Sbjct 3836 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3895
Query 3890 SLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
SLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD
Sbjct 3896 SLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3955
Query 3950 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM
Sbjct 3956 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4015
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA
Sbjct 4016 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4075
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4129
SALWEIQQVVDADSKIVQLSEINMDNS NLAWPLIVTALRANSAVKLQNNELSPVALRQM
Sbjct 4076 SALWEIQQVVDADSKIVQLSEINMDNSQNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4135
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP
Sbjct 4136 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4195
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAF 4249
CRFVTDTP+GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANS VLSFCAF
Sbjct 4196 CRFVTDTPRGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSAVLSFCAF 4255
Query 4250 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4309
AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC
Sbjct 4256 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4315
Query 4310 HIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ 4369
HIDHPNPKGFCDLKGKYVQIP TCANDPVGFTL+NTVCTVCG WKGYGCSCDQLREP+MQ
Sbjct 4316 HIDHPNPKGFCDLKGKYVQIPATCANDPVGFTLKNTVCTVCGTWKGYGCSCDQLREPMMQ 4375
Query 4370 SADASTFLNGFAV 4382
SADASTFLNGFAV
Sbjct 4376 SADASTFLNGFAV 4388
>sp|P0C6V9|R1AB_BC279 Replicase polyprotein 1ab OS=Bat coronavirus
279/2005 OX=389167 GN=rep PE=3 SV=1
Length=7079
Score = 8491 bits (22032), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 4093/4389 (93%), Positives = 4237/4389 (97%), Gaps = 16/4389 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESL LGV+EKTHVQLSLPVLQVRDVLVRGFGDSVEEAL+EAREHLKNGTCGLVELEKGV
Sbjct 1 MESLALGVSEKTHVQLSLPVLQVRDVLVRGFGDSVEEALAEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA TNHG+KVVELVAE+DGIQYGRSG TLGVLVPHVGETP+AYRN
Sbjct 61 LPQLEQPYVFIKRSDAQGTNHGYKVVELVAELDGIQYGRSGTTLGVLVPHVGETPVAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLG ELGTDPIEDYEQNWNTKHG G LREL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGVELGTDPIEDYEQNWNTKHGGGVLRELIRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 AFTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYE QTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYERQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVFAYVGCYNKR
Sbjct 361 PANAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITGDNVETLNEDL+EIL+R+RVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASANIGASHTGITGDNVETLNEDLMEILNRDRVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAST AF+DT+K LDYK+FK IVESCGN+KVT+G+ KGAWNIGQ++S+LTPL GFPSQA
Sbjct 481 SASTCAFVDTVKGLDYKTFKDIVESCGNFKVTRGRAKKGAWNIGQEKSILTPLYGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF R LD ANHSIPDLQRAA+TILDGISEQSLRL+DAMVYTSDLLTNSVI+MAY
Sbjct 541 AGVIRSIFTRALDTANHSIPDLQRAAITILDGISEQSLRLIDAMVYTSDLLTNSVIVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQ +QWLSN+LGTTV+KL+P+F W+EAKLSAG+EFL+DAWEILKFL+TGVFDIV
Sbjct 601 VTGGLVQQITQWLSNMLGTTVDKLKPVFTWVEAKLSAGIEFLRDAWEILKFLVTGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDN+K+CVK F+DV+NKALEMCIDQV IAGAKLR+LNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNLKECVKAFLDVLNKALEMCIDQVIIAGAKLRTLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPL+APKEVTF EGDSHDTV TSEEVVLKNGELEALETPVDSFTNGA++G
Sbjct 721 IRGKEQLQLLMPLRAPKEVTFFEGDSHDTVFTSEEVVLKNGELEALETPVDSFTNGAVIG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLE+KDKEQYCALSPGLLATNNVF LKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCVNGLMLLELKDKEQYCALSPGLLATNNVFSLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 KITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE-HEYGTEDDYQG 959
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEEI E HEYGTEDDY+G
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEEYEDEEEIPEETCEHEYGTEDDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS E +++ +EE+ D E +PEPEP PEEPVNQFTGYLKLTDNVAIK
Sbjct 961 LPLEFGASTE---IQQVDEEEEEDWLEEAIAAKPEPEPLPEEPVNQFTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIVKEAQ A P VIVNAAN+HLKHGGGVAGALNKATNGAMQ+ESDDYIK NGPLTVGG
Sbjct 1018 CVDIVKEAQHAKPTVIVNAANVHLKHGGGVAGALNKATNGAMQQESDDYIKKNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKC+HVVGPNLNAGED+QLLKAAY NFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCMHVVGPNLNAGEDVQLLKAAYANFNSQDVLLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE----------EPPNTED 1189
L++CV+TVRTQVY AVND+ LY+ VV+ YLD+LKP+VE P QE E E+
Sbjct 1138 LKMCVETVRTQVYFAVNDQDLYDHVVLGYLDSLKPKVETPTQENLELKEQPAVETLTQEN 1197
Query 1190 SKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRG 1249
+ EE V++KPVDVK KA I+EV T+LEETKFLT++LLLFADINGKLY DSQNMLRG
Sbjct 1198 LELEELPVIEKPVDVK--FKARIEEVNTSLEETKFLTSRLLLFADINGKLYQDSQNMLRG 1255
Query 1250 EDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQG 1309
EDM FLEKDAPY+VGDVI+SGDITCV+IP+KKAGGTTEML++ALKKVPV EYITTYPGQG
Sbjct 1256 EDMFFLEKDAPYIVGDVISSGDITCVIIPAKKAGGTTEMLAKALKKVPVSEYITTYPGQG 1315
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICM 1369
CAGYTLEEAKTAL+KCKS FYVLPS+ PN KEEILGTVSWNLREMLAHAEETRKLM ICM
Sbjct 1316 CAGYTLEEAKTALRKCKSVFYVLPSKTPNDKEEILGTVSWNLREMLAHAEETRKLMLICM 1375
Query 1370 DVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYV 1429
DV+A+M+TI R+YKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLN LNEPLVTMPIGYV
Sbjct 1376 DVKALMSTIHRRYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNLLNEPLVTMPIGYV 1435
Query 1430 THGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRD 1489
THG NLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF+ETVSLAG YRD
Sbjct 1436 THGLNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFIETVSLAGMYRD 1495
Query 1490 WSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFT 1549
WSYSGQRTELGVEFLKRGDK+VYHT+ SP++FHLDGEVL LDKLKSLLSLREV+TIKVFT
Sbjct 1496 WSYSGQRTELGVEFLKRGDKVVYHTVGSPIQFHLDGEVLLLDKLKSLLSLREVRTIKVFT 1555
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF 1609
TVDNTNLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH HEGKTFFVLPSDDTLRSEAF
Sbjct 1556 TVDNTNLHTQIVDMSMTYGQQFGPTYLDGADVTKIKPHAKHEGKTFFVLPSDDTLRSEAF 1615
Query 1610 EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNA 1669
EYYHTLDESFLGRYMSALNHTKKWKFPQ+GGLTSIKWADNNCYLSSVLLALQQ+EVKFNA
Sbjct 1616 EYYHTLDESFLGRYMSALNHTKKWKFPQIGGLTSIKWADNNCYLSSVLLALQQIEVKFNA 1675
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1729
PALQEAYYRARAGDAANFCALILAYSN+TVGELGDVRETMTHLLQHANLESAKRVLNVVC
Sbjct 1676 PALQEAYYRARAGDAANFCALILAYSNRTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1735
Query 1730 KHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA 1789
K CGQK+TTLTGVEAVMYMGTLSY+ LKTGV+IPC+CGRDATQYLVQQESSFVMMSAPP+
Sbjct 1736 KTCGQKSTTLTGVEAVMYMGTLSYEELKTGVTIPCICGRDATQYLVQQESSFVMMSAPPS 1795
Query 1790 EYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
EY LQQG FLCANEYTG+YQCGHYTH+T KETLYRIDGA+LTKMSEYKGPVTDVFYKE S
Sbjct 1796 EYTLQQGAFLCANEYTGSYQCGHYTHVTVKETLYRIDGAYLTKMSEYKGPVTDVFYKEIS 1855
Query 1850 YTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1909
YTTTIKPVSYKLDGV YTEI+PKLD YYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC
Sbjct 1856 YTTTIKPVSYKLDGVIYTEIQPKLDEYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1915
Query 1910 SNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW 1969
SNTKFADDLNQMTGF KPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPI+W
Sbjct 1916 SNTKFADDLNQMTGFKKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW 1975
Query 1970 HINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVV 2029
HINQ T KTT+KPNTWCLRCLWSTKPV+TSNSFEVL VEDTQGMDNLACESQ PTSEEVV
Sbjct 1976 HINQTTNKTTYKPNTWCLRCLWSTKPVETSNSFEVLEVEDTQGMDNLACESQTPTSEEVV 2035
Query 2030 ENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
ENPTIQKEVIECDVKT EVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNE
Sbjct 2036 ENPTIQKEVIECDVKTIEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNE 2095
Query 2090 LSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYV 2149
LSLALGL+T+ATHG AAINSVPWSKILAYVKPFLGQAA+TT+NC KR QRVFNNYMPYV
Sbjct 2096 LSLALGLRTLATHGAAAINSVPWSKILAYVKPFLGQAAVTTTNCIKRCVQRVFNNYMPYV 2155
Query 2150 FTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMW 2209
TLLFQLCTFT+STNSRIRASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTIAMW
Sbjct 2156 ITLLFQLCTFTRSTNSRIRASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIAMW 2215
Query 2210 LLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICL 2269
LLLLSICLGSLI VTAAFGVLLSN G PSYC+GVRE Y+NSSNVTTMDFCEGSF CS+CL
Sbjct 2216 LLLLSICLGSLIYVTAAFGVLLSNLGIPSYCDGVRESYVNSSNVTTMDFCEGSFLCSVCL 2275
Query 2270 SGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFG 2329
+GLDSLDSYPALETIQVTISSYKLDLT LGLAAEW LAYMLFTKFFYLLGLSAIMQVFFG
Sbjct 2276 NGLDSLDSYPALETIQVTISSYKLDLTSLGLAAEWFLAYMLFTKFFYLLGLSAIMQVFFG 2335
Query 2330 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMC 2389
YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFA YY+WKSYVHIMDGCTSSTCMMC
Sbjct 2336 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFAFCYYVWKSYVHIMDGCTSSTCMMC 2395
Query 2390 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARD 2449
YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARD
Sbjct 2396 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARD 2455
Query 2450 LSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2509
LSLQFKRPINPTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT
Sbjct 2456 LSLQFKRPINPTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2515
Query 2510 KGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2569
KGSLPINVIVFDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD
Sbjct 2516 KGSLPINVIVFDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2575
Query 2570 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2629
AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI
Sbjct 2576 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2635
Query 2630 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2689
ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI
Sbjct 2636 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2695
Query 2690 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKL 2749
WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN ITTKISLKGGKIVST FKL
Sbjct 2696 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNAITTKISLKGGKIVSTWFKL 2755
Query 2750 MLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
MLKATLLCVLAAL CYI+MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI++TDDCFANKHA
Sbjct 2756 MLKATLLCVLAALFCYIIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIMATDDCFANKHA 2815
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
GFD+WFSQRGGSY+NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV
Sbjct 2816 GFDSWFSQRGGSYRNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2875
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT
Sbjct 2876 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2935
Query 2930 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYR 2989
RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE G+CLSTSGRWVLNNEHYR
Sbjct 2936 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEAGVCLSTSGRWVLNNEHYR 2995
Query 2990 ALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFG 3049
AL GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FG
Sbjct 2996 ALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFG 3055
Query 3050 EYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMF 3109
EYNHVVAANALLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMF
Sbjct 3056 EYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMF 3115
Query 3110 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3169
SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK
Sbjct 3116 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3175
Query 3170 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3229
LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP
Sbjct 3176 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3235
Query 3230 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3289
PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM
Sbjct 3236 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3295
Query 3290 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3349
LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG
Sbjct 3296 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3355
Query 3350 QTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3409
QTFSVLACYNGSPSGVYQCAMRPN+TIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT
Sbjct 3356 QTFSVLACYNGSPSGVYQCAMRPNYTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3415
Query 3410 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3469
GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND
Sbjct 3416 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3475
Query 3470 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3529
FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED
Sbjct 3476 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3535
Query 3530 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3589
EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL
Sbjct 3536 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3595
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT
Sbjct 3596 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3655
Query 3650 SLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAIS 3709
SLSGYRLKDCVMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAIS
Sbjct 3656 SLSGYRLKDCVMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAIS 3715
Query 3710 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3769
MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC
Sbjct 3716 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3775
Query 3770 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3829
YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC
Sbjct 3776 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3835
Query 3830 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3889
IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV
Sbjct 3836 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3895
Query 3890 SLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
SLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD
Sbjct 3896 SLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3955
Query 3950 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM
Sbjct 3956 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4015
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA
Sbjct 4016 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4075
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4129
SALWEIQQVVDADSKIVQLSEINMDNS NLAWPLIVTALRANSAVKLQNNELSPVALRQM
Sbjct 4076 SALWEIQQVVDADSKIVQLSEINMDNSQNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4135
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP
Sbjct 4136 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4195
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAF 4249
CRFVTDTP+GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANS VLSFCAF
Sbjct 4196 CRFVTDTPRGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSAVLSFCAF 4255
Query 4250 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4309
AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC
Sbjct 4256 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4315
Query 4310 HIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ 4369
HIDHPNPKGFCDLKGKYVQIP TCANDPVGFTL+NTVCTVCG WKGYGCSCDQLREP+MQ
Sbjct 4316 HIDHPNPKGFCDLKGKYVQIPATCANDPVGFTLKNTVCTVCGTWKGYGCSCDQLREPMMQ 4375
Query 4370 SADASTFLN 4378
SADASTFLN
Sbjct 4376 SADASTFLN 4384
>sp|P0DTC1|R1A_SARS2 Replicase polyprotein 1a OS=Severe acute
respiratory syndrome coronavirus 2 OX=2697049 PE=1 SV=1
Length=4405
Score = 7506 bits (19476), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 3549/4412 (80%), Positives = 3949/4412 (90%), Gaps = 37/4412 (1%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLV G NEKTHVQLSLPVLQVRDVLVRGFGDSVEE LSEAR+HLK+GTCGLVE+EKGV
Sbjct 1 MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA + HGH +VELVAE++GIQYGRSG TLGVLVPHVGE P+AYR
Sbjct 61 LPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRK 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYG DLKS+DLGDELGTDP ED+++NWNTKH SG REL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGK+ CTLSEQLD+I++KRGVYCCR+HEHEIAW
Sbjct 181 AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
+TERS+KSYE QTPFEIK AKKFDTF GECP FVFPLNS +K IQPRVEKKK +GFMGRI
Sbjct 241 YTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASP ECN M LSTLMKC+HC E SWQT DF+KATCE CGTENL EG TTCGYL
Sbjct 301 RSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVK+ CPAC + E+GPEHS+A+YHN S ++T LRKGGRT FGGCVF+YVGC+NK
Sbjct 361 PQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKC 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG HTG+ G+ E LN++LLEIL +E+VNINIVGDF LNEE+AIILASF
Sbjct 421 AYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAF++T+K LDYK+FK IVESCGN+KVTKGK KGAWNIG+Q+S+L+PL F S+A
Sbjct 481 SASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
A V+RSIF+RTL+ A +S+ LQ+AA+TILDGIS+ SLRL+DAM++TSDL TN++++MAY
Sbjct 541 ARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
+TGG+VQ TSQWL+N+ GT EKL+P+ +W+E K GVEFL+D WEI+KF+ T +IV
Sbjct 601 ITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
GQI + IK+ V+ F +VNK L +C D + I GAKL++LNLGE F+ SKGLYR+C
Sbjct 661 GGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
++ +E+ LLMPLKAPKE+ FLEG++ T + +EEVVLK G+L+ LE P +VG
Sbjct 721 VKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIKD E+YCAL+P ++ TNN F LKGGAP K VTFG+DTV EVQGYK+V
Sbjct 781 TPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTK-VTFGDDTVIEVQGYKSV 839
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
ITFELDER+DKVLNEKCS YTVE GTEV EFACVVA+AV+KTLQPVS+LLT +GIDLDE
Sbjct 840 NITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDE 899
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WS+AT+YLFD++GE +S MYCSFYPPDE+EE+ EEE T ++EYGTEDDYQG
Sbjct 900 WSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPST-QYEYGTEDDYQGK 958
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQS-------------------EIEP--EPEPTP 999
PLEFGA++ ++ EEE+EEDWLDD ++Q+ E++P E E TP
Sbjct 959 PLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTP 1018
Query 1000 ---EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKA 1056
VN F+GYLKLTDNV IK DIV+EA+ P V+VNAAN++LKHGGGVAGALNKA
Sbjct 1019 VVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKA 1078
Query 1057 TNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
TN AMQ ESDDYI NGPL VGGSC+LSGHNLAK CLHVVGPN+N GEDIQLLK+AYENF
Sbjct 1079 TNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENF 1138
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR- 1175
N ++LLAPLLSAGIFGA P+ SL+VCV TVRT VY+AV DK LY+++V +L+ +
Sbjct 1139 NQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQ 1198
Query 1176 -----VEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL 1230
E PK+E P +SK SV Q+ D K KIKAC++EVTTTLEETKFLT LL
Sbjct 1199 VEQKIAEIPKEEVKPFITESK---PSVEQRKQDDK-KIKACVEEVTTTLEETKFLTENLL 1254
Query 1231 LFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLS 1290
L+ DING L+ DS ++ D++FL+KDAPY+VGDV+ G +T VVIP+KKAGGTTEML+
Sbjct 1255 LYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLA 1314
Query 1291 RALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWN 1350
+AL+KVP D YITTYPGQG GYT+EEAKT LKKCKSAFY+LPS N K+EILGTVSWN
Sbjct 1315 KALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWN 1374
Query 1351 LREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASI 1410
LREMLAHAEETRKLMP+C++ +AI++TIQRKYKGIKIQEG+VDYG RF+FYTSK VAS+
Sbjct 1375 LREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASL 1434
Query 1411 ITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSS 1470
I LN LNE LVTMP+GYVTHG NLEEAAR MRSLK PA VSVSSPDAVT YNGYLTSSS
Sbjct 1435 INTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS 1494
Query 1471 KTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSL 1530
KT EEHF+ET+SLAGSY+DWSYSGQ T+LG+EFLKRGDK VY+T +P FHLDGEV++
Sbjct 1495 KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYT-SNPTTFHLDGEVITF 1553
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNH 1590
D LK+LLSLREV+TIKVFTTVDN NLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH +H
Sbjct 1554 DNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSH 1613
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
EGKTF+VLP+DDTLR EAFEYYHT D SFLGRYMSALNHTKKWK+PQV GLTSIKWADNN
Sbjct 1614 EGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNN 1673
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
CYL++ LL LQQ+E+KFN PALQ+AYYRARAG+AANFCALILAY NKTVGELGDVRETM+
Sbjct 1674 CYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMS 1733
Query 1711 HLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDA 1770
+L QHANL+S KRVLNVVCK CGQ+ TTL GVEAVMYMGTLSY+ K GV IPC CG+ A
Sbjct 1734 YLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQA 1793
Query 1771 TQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHL 1830
T+YLVQQES FVMMSAPPA+Y+L+ GTF CA+EYTGNYQCGHY HIT+KETLY IDGA L
Sbjct 1794 TKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL 1853
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPID 1890
TK SEYKGP+TDVFYKE SYTTTIKPV+YKLDGV TEI+PKLD YYKKDN+Y+TEQPID
Sbjct 1854 TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPID 1913
Query 1891 LVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYR 1950
LVP QP PNASFDNFK C N KFADDLNQ+TG+ KPASREL VTFFPDLNGDVVAIDY+
Sbjct 1914 LVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYK 1973
Query 1951 HYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDT 2010
HY+ SFKKGAKLLHKPIVWH+N AT K T+KPNTWC+RCLWSTKPV+TSNSF+VL ED
Sbjct 1974 HYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDA 2033
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
QGMDNLACE +P SEEVVENPTIQK+V+EC+VKTTEVVG++ILKP++ +K+T+E+GH
Sbjct 2034 QGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHT 2093
Query 2071 DLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITT 2130
DLMAAYV+N+S+TIKKPNELS LGLKT+ATHG+AA+NSVPW I Y KPFL + TT
Sbjct 2094 DLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTT 2153
Query 2131 SNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDA 2190
+N R RV NYMPY FTLL QLCTFT+STNSRI+AS+PTTIAKN+VKSV K CL+A
Sbjct 2154 TNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEA 2213
Query 2191 GINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNS 2250
NY+KSP FSKL I +W LLLS+CLGSLI TAA GVL+SN G PSYC G RE YLNS
Sbjct 2214 SFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNS 2273
Query 2251 SNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML 2310
+NVT +C GS PCS+CLSGLDSLD+YP+LETIQ+TISS+K DLT GL AEW LAY+L
Sbjct 2274 TNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYIL 2333
Query 2311 FTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FT+FFY+LGL+AIMQ+FF YFA HFISNSWLMW II++VQMAP+SAMVRMYIFFASFYY+
Sbjct 2334 FTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYV 2393
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
WKSYVH++DGC SSTCMMCYKRNRATRVECTTIVNG++RSFYVYANGG+GFCK HNWNC+
Sbjct 2394 WKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCV 2453
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NCDTFC GSTFISDEVARDLSLQFKRPINPTDQSSYIVDSV VKNG++HLYFDKAGQKTY
Sbjct 2454 NCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTY 2513
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
ERH LSHFVNLDNLRANNTKGSLPINVIVFDGKSKC+ES++KSASVYYSQLMCQPILLLD
Sbjct 2514 ERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLD 2573
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
QALVSDVGDS EV+VKMFDAYV+TFS+TF+VPMEKLK LVATA +ELAK V+LD VLSTF
Sbjct 2574 QALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTF 2633
Query 2611 VSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACID 2670
+SAARQG VD+DV+TKDV+ECLKLSH SD+EVTGDSCNN+MLTYNKVENMTPRDLGACID
Sbjct 2634 ISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACID 2693
Query 2671 CNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNV 2730
C+ARHINAQVAKSHN++LIWNVKD+MSLSEQLRKQIRSAAKKNN+PF+LTCATTRQVVNV
Sbjct 2694 CSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNV 2753
Query 2731 ITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQ 2790
+TTKI+LKGGKIV+ K ++K TL+ + A + Y++ PVH +S H +++EIIGYKAI
Sbjct 2754 VTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAID 2813
Query 2791 DGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTV 2850
GVTRDI STD CFANKHA FD WFSQRGGSY NDK+CP++AA+ITRE+GF+VPGLPGT+
Sbjct 2814 GGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTI 2873
Query 2851 LRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYC 2910
LR NGDFLHFLPRVFSAVGNICYTPSKLIEY+DFATSACVLAAECTIFKDA GKPVPYC
Sbjct 2874 LRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYC 2933
Query 2911 YDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE 2970
YDTN+LEGS++Y LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFD+EYCRHGTCERSE
Sbjct 2934 YDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSE 2993
Query 2971 VGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGII 3030
G+C+STSGRWVLNN++YR+L GVFCGVDA+NL+ N+FTPL+QP+GALD+SAS+VAGGI+
Sbjct 2994 AGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIV 3053
Query 3031 AILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT 3090
AI+VTC AYYFM+FRR FGEY+HVVA N LLFLMSFT+LCL P YSFLPGVYSV YLYLT
Sbjct 3054 AIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLT 3113
Query 3091 FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFS 3150
FY TNDVSFLAH+QW MF+P+VPFWIT Y+ CIS KH +WFF+NYL++RV+FNGV+FS
Sbjct 3114 FYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFS 3173
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
TFEEAALCTFLLNKEMYLKLRS+ LLPLTQYNRYLALYNKYKYFSGA+DTTSYREAACCH
Sbjct 3174 TFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCH 3233
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKALNDFSNSG+DVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
Sbjct 3234 LAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3293
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVICT+EDMLNPNYEDLLIRKSNH+FLVQAGNVQLRVIGHSMQNC+L+LK
Sbjct 3294 WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLK 3353
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
VDT+NPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN TIKGSFLNGSCGSVGF
Sbjct 3354 VDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF 3413
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NIDYDCVSFCYMHHMELPTGVHAGTDLEG FYGPFVDRQTAQAAGTDTTIT+NVLAWLYA
Sbjct 3414 NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYA 3473
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA+LKE
Sbjct 3474 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKE 3533
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
LLQNGMNGRTILGS +LEDEFTPFDVVRQCSGVTFQ K+ +KGTHHW+LLT LTSLL+
Sbjct 3534 LLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLV 3593
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
LVQSTQWSLFFF+YENAFLPF +GI+A++A AM+ VKHKHAFLCLFLLPSLATVAYFNMV
Sbjct 3594 LVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMV 3653
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMN 3690
YMPASWVMRIMTWL++ DTSLSG++LKDCVMYASA+VLLILMTARTVYDD ARRVWTLMN
Sbjct 3654 YMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMN 3713
Query 3691 VITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
V+TLVYKVYYGNALDQAISMWAL+ISVTSNYSGVVTT+MFLAR IVF+CVEY P+ FITG
Sbjct 3714 VLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITG 3773
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKS 3810
NTLQCIMLVYCFLGY C CYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPK+
Sbjct 3774 NTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKN 3833
Query 3811 SIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3870
SIDAFKLNIKLLG+GGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ
Sbjct 3834 SIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3893
Query 3871 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPS 3930
LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPS
Sbjct 3894 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPS 3953
Query 3931 YAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 3990
YAA+ATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY
Sbjct 3954 YAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 4013
Query 3991 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4050
KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV
Sbjct 4014 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4073
Query 4051 VPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRA 4110
+PDY TYKNTCDG TFTYASALWEIQQVVDADSKIVQLSEI+MDNSPNLAWPLIVTALRA
Sbjct 4074 IPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA 4133
Query 4111 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKW 4170
NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN +KGGRFVLALLSD QDLKW
Sbjct 4134 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKW 4193
Query 4171 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4230
ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ
Sbjct 4194 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4253
Query 4231 AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
AGNATEVPANSTVLSFCAFAVD AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE
Sbjct 4254 AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4313
Query 4291 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVC 4350
ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTL+NTVCTVC
Sbjct 4314 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVC 4373
Query 4351 GMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
GMWKGYGCSCDQLREP++QSADA +FLNGFAV
Sbjct 4374 GMWKGYGCSCDQLREPMLQSADAQSFLNGFAV 4405
>sp|P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab OS=Severe acute
respiratory syndrome coronavirus 2 OX=2697049 GN=rep PE=1
SV=1
Length=7096
Score = 7477 bits (19401), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 3545/4408 (80%), Positives = 3945/4408 (89%), Gaps = 37/4408 (1%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLV G NEKTHVQLSLPVLQVRDVLVRGFGDSVEE LSEAR+HLK+GTCGLVE+EKGV
Sbjct 1 MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA + HGH +VELVAE++GIQYGRSG TLGVLVPHVGE P+AYR
Sbjct 61 LPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRK 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYG DLKS+DLGDELGTDP ED+++NWNTKH SG REL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGK+ CTLSEQLD+I++KRGVYCCR+HEHEIAW
Sbjct 181 AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
+TERS+KSYE QTPFEIK AKKFDTF GECP FVFPLNS +K IQPRVEKKK +GFMGRI
Sbjct 241 YTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASP ECN M LSTLMKC+HC E SWQT DF+KATCE CGTENL EG TTCGYL
Sbjct 301 RSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVK+ CPAC + E+GPEHS+A+YHN S ++T LRKGGRT FGGCVF+YVGC+NK
Sbjct 361 PQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKC 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG HTG+ G+ E LN++LLEIL +E+VNINIVGDF LNEE+AIILASF
Sbjct 421 AYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAF++T+K LDYK+FK IVESCGN+KVTKGK KGAWNIG+Q+S+L+PL F S+A
Sbjct 481 SASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
A V+RSIF+RTL+ A +S+ LQ+AA+TILDGIS+ SLRL+DAM++TSDL TN++++MAY
Sbjct 541 ARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
+TGG+VQ TSQWL+N+ GT EKL+P+ +W+E K GVEFL+D WEI+KF+ T +IV
Sbjct 601 ITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
GQI + IK+ V+ F +VNK L +C D + I GAKL++LNLGE F+ SKGLYR+C
Sbjct 661 GGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
++ +E+ LLMPLKAPKE+ FLEG++ T + +EEVVLK G+L+ LE P +VG
Sbjct 721 VKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIKD E+YCAL+P ++ TNN F LKGGAP K VTFG+DTV EVQGYK+V
Sbjct 781 TPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTK-VTFGDDTVIEVQGYKSV 839
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
ITFELDER+DKVLNEKCS YTVE GTEV EFACVVA+AV+KTLQPVS+LLT +GIDLDE
Sbjct 840 NITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDE 899
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WS+AT+YLFD++GE +S MYCSFYPPDE+EE+ EEE T ++EYGTEDDYQG
Sbjct 900 WSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPST-QYEYGTEDDYQGK 958
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQS-------------------EIEP--EPEPTP 999
PLEFGA++ ++ EEE+EEDWLDD ++Q+ E++P E E TP
Sbjct 959 PLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTP 1018
Query 1000 ---EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKA 1056
VN F+GYLKLTDNV IK DIV+EA+ P V+VNAAN++LKHGGGVAGALNKA
Sbjct 1019 VVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKA 1078
Query 1057 TNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
TN AMQ ESDDYI NGPL VGGSC+LSGHNLAK CLHVVGPN+N GEDIQLLK+AYENF
Sbjct 1079 TNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENF 1138
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR- 1175
N ++LLAPLLSAGIFGA P+ SL+VCV TVRT VY+AV DK LY+++V +L+ +
Sbjct 1139 NQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQ 1198
Query 1176 -----VEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL 1230
E PK+E P +SK SV Q+ D K KIKAC++EVTTTLEETKFLT LL
Sbjct 1199 VEQKIAEIPKEEVKPFITESK---PSVEQRKQDDK-KIKACVEEVTTTLEETKFLTENLL 1254
Query 1231 LFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLS 1290
L+ DING L+ DS ++ D++FL+KDAPY+VGDV+ G +T VVIP+KKAGGTTEML+
Sbjct 1255 LYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLA 1314
Query 1291 RALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWN 1350
+AL+KVP D YITTYPGQG GYT+EEAKT LKKCKSAFY+LPS N K+EILGTVSWN
Sbjct 1315 KALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWN 1374
Query 1351 LREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASI 1410
LREMLAHAEETRKLMP+C++ +AI++TIQRKYKGIKIQEG+VDYG RF+FYTSK VAS+
Sbjct 1375 LREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASL 1434
Query 1411 ITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSS 1470
I LN LNE LVTMP+GYVTHG NLEEAAR MRSLK PA VSVSSPDAVT YNGYLTSSS
Sbjct 1435 INTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS 1494
Query 1471 KTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSL 1530
KT EEHF+ET+SLAGSY+DWSYSGQ T+LG+EFLKRGDK VY+T +P FHLDGEV++
Sbjct 1495 KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYT-SNPTTFHLDGEVITF 1553
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNH 1590
D LK+LLSLREV+TIKVFTTVDN NLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH +H
Sbjct 1554 DNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSH 1613
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
EGKTF+VLP+DDTLR EAFEYYHT D SFLGRYMSALNHTKKWK+PQV GLTSIKWADNN
Sbjct 1614 EGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNN 1673
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
CYL++ LL LQQ+E+KFN PALQ+AYYRARAG+AANFCALILAY NKTVGELGDVRETM+
Sbjct 1674 CYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMS 1733
Query 1711 HLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDA 1770
+L QHANL+S KRVLNVVCK CGQ+ TTL GVEAVMYMGTLSY+ K GV IPC CG+ A
Sbjct 1734 YLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQA 1793
Query 1771 TQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHL 1830
T+YLVQQES FVMMSAPPA+Y+L+ GTF CA+EYTGNYQCGHY HIT+KETLY IDGA L
Sbjct 1794 TKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL 1853
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPID 1890
TK SEYKGP+TDVFYKE SYTTTIKPV+YKLDGV TEI+PKLD YYKKDN+Y+TEQPID
Sbjct 1854 TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPID 1913
Query 1891 LVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYR 1950
LVP QP PNASFDNFK C N KFADDLNQ+TG+ KPASREL VTFFPDLNGDVVAIDY+
Sbjct 1914 LVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYK 1973
Query 1951 HYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDT 2010
HY+ SFKKGAKLLHKPIVWH+N AT K T+KPNTWC+RCLWSTKPV+TSNSF+VL ED
Sbjct 1974 HYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDA 2033
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
QGMDNLACE +P SEEVVENPTIQK+V+EC+VKTTEVVG++ILKP++ +K+T+E+GH
Sbjct 2034 QGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHT 2093
Query 2071 DLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITT 2130
DLMAAYV+N+S+TIKKPNELS LGLKT+ATHG+AA+NSVPW I Y KPFL + TT
Sbjct 2094 DLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTT 2153
Query 2131 SNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDA 2190
+N R RV NYMPY FTLL QLCTFT+STNSRI+AS+PTTIAKN+VKSV K CL+A
Sbjct 2154 TNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEA 2213
Query 2191 GINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNS 2250
NY+KSP FSKL I +W LLLS+CLGSLI TAA GVL+SN G PSYC G RE YLNS
Sbjct 2214 SFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNS 2273
Query 2251 SNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML 2310
+NVT +C GS PCS+CLSGLDSLD+YP+LETIQ+TISS+K DLT GL AEW LAY+L
Sbjct 2274 TNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYIL 2333
Query 2311 FTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FT+FFY+LGL+AIMQ+FF YFA HFISNSWLMW II++VQMAP+SAMVRMYIFFASFYY+
Sbjct 2334 FTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYV 2393
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
WKSYVH++DGC SSTCMMCYKRNRATRVECTTIVNG++RSFYVYANGG+GFCK HNWNC+
Sbjct 2394 WKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCV 2453
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NCDTFC GSTFISDEVARDLSLQFKRPINPTDQSSYIVDSV VKNG++HLYFDKAGQKTY
Sbjct 2454 NCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTY 2513
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
ERH LSHFVNLDNLRANNTKGSLPINVIVFDGKSKC+ES++KSASVYYSQLMCQPILLLD
Sbjct 2514 ERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLD 2573
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
QALVSDVGDS EV+VKMFDAYV+TFS+TF+VPMEKLK LVATA +ELAK V+LD VLSTF
Sbjct 2574 QALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTF 2633
Query 2611 VSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACID 2670
+SAARQG VD+DV+TKDV+ECLKLSH SD+EVTGDSCNN+MLTYNKVENMTPRDLGACID
Sbjct 2634 ISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACID 2693
Query 2671 CNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNV 2730
C+ARHINAQVAKSHN++LIWNVKD+MSLSEQLRKQIRSAAKKNN+PF+LTCATTRQVVNV
Sbjct 2694 CSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNV 2753
Query 2731 ITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQ 2790
+TTKI+LKGGKIV+ K ++K TL+ + A + Y++ PVH +S H +++EIIGYKAI
Sbjct 2754 VTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAID 2813
Query 2791 DGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTV 2850
GVTRDI STD CFANKHA FD WFSQRGGSY NDK+CP++AA+ITRE+GF+VPGLPGT+
Sbjct 2814 GGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTI 2873
Query 2851 LRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYC 2910
LR NGDFLHFLPRVFSAVGNICYTPSKLIEY+DFATSACVLAAECTIFKDA GKPVPYC
Sbjct 2874 LRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYC 2933
Query 2911 YDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE 2970
YDTN+LEGS++Y LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFD+EYCRHGTCERSE
Sbjct 2934 YDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSE 2993
Query 2971 VGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGII 3030
G+C+STSGRWVLNN++YR+L GVFCGVDA+NL+ N+FTPL+QP+GALD+SAS+VAGGI+
Sbjct 2994 AGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIV 3053
Query 3031 AILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT 3090
AI+VTC AYYFM+FRR FGEY+HVVA N LLFLMSFT+LCL P YSFLPGVYSV YLYLT
Sbjct 3054 AIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLT 3113
Query 3091 FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFS 3150
FY TNDVSFLAH+QW MF+P+VPFWIT Y+ CIS KH +WFF+NYL++RV+FNGV+FS
Sbjct 3114 FYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFS 3173
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
TFEEAALCTFLLNKEMYLKLRS+ LLPLTQYNRYLALYNKYKYFSGA+DTTSYREAACCH
Sbjct 3174 TFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCH 3233
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKALNDFSNSG+DVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
Sbjct 3234 LAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3293
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVICT+EDMLNPNYEDLLIRKSNH+FLVQAGNVQLRVIGHSMQNC+L+LK
Sbjct 3294 WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLK 3353
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
VDT+NPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN TIKGSFLNGSCGSVGF
Sbjct 3354 VDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF 3413
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NIDYDCVSFCYMHHMELPTGVHAGTDLEG FYGPFVDRQTAQAAGTDTTIT+NVLAWLYA
Sbjct 3414 NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYA 3473
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA+LKE
Sbjct 3474 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKE 3533
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
LLQNGMNGRTILGS +LEDEFTPFDVVRQCSGVTFQ K+ +KGTHHW+LLT LTSLL+
Sbjct 3534 LLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLV 3593
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
LVQSTQWSLFFF+YENAFLPF +GI+A++A AM+ VKHKHAFLCLFLLPSLATVAYFNMV
Sbjct 3594 LVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMV 3653
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMN 3690
YMPASWVMRIMTWL++ DTSLSG++LKDCVMYASA+VLLILMTARTVYDD ARRVWTLMN
Sbjct 3654 YMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMN 3713
Query 3691 VITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
V+TLVYKVYYGNALDQAISMWAL+ISVTSNYSGVVTT+MFLAR IVF+CVEY P+ FITG
Sbjct 3714 VLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITG 3773
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKS 3810
NTLQCIMLVYCFLGY C CYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPK+
Sbjct 3774 NTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKN 3833
Query 3811 SIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3870
SIDAFKLNIKLLG+GGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ
Sbjct 3834 SIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3893
Query 3871 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPS 3930
LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPS
Sbjct 3894 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPS 3953
Query 3931 YAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 3990
YAA+ATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY
Sbjct 3954 YAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 4013
Query 3991 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4050
KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV
Sbjct 4014 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4073
Query 4051 VPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRA 4110
+PDY TYKNTCDG TFTYASALWEIQQVVDADSKIVQLSEI+MDNSPNLAWPLIVTALRA
Sbjct 4074 IPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA 4133
Query 4111 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKW 4170
NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN +KGGRFVLALLSD QDLKW
Sbjct 4134 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKW 4193
Query 4171 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4230
ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ
Sbjct 4194 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4253
Query 4231 AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
AGNATEVPANSTVLSFCAFAVD AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE
Sbjct 4254 AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4313
Query 4291 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVC 4350
ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTL+NTVCTVC
Sbjct 4314 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVC 4373
Query 4351 GMWKGYGCSCDQLREPLMQSADASTFLN 4378
GMWKGYGCSCDQLREP++QSADA +FLN
Sbjct 4374 GMWKGYGCSCDQLREPMLQSADAQSFLN 4401
>sp|P0C6T5|R1A_BCHK5 Replicase polyprotein 1a OS=Bat coronavirus
HKU5 OX=694008 GN=1a PE=3 SV=1
Length=4481
Score = 2341 bits (6066), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1544/4567 (34%), Positives = 2380/4567 (52%), Gaps = 320/4567 (7%)
Query 13 HVQLSLPVLQVRDVLVR---GFGDSVEEALSEAREHLKNGTCGLV--ELEKGVLPQLEQP 67
HV L + D++++ F D E A E L G+ L + KG + L P
Sbjct 28 HVSLKASLCDAGDLVLKISPWFMDG-ESAYKHVSEQLSKGSKLLFVPQTLKGFIRHLPGP 86
Query 68 YVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITL-----GVLVPHVGETPIAYRNVL 122
V++ T +V +A + G G TL G+ P + L
Sbjct 87 RVYLVERLTGGTYSDPFMVNQLAYQNAAGEGVIGTTLQGKRVGMFFPFDADLVTGEFQFL 146
Query 123 LRKNGNKGAGGHSYGIDLKSY------DLGDELGTDPIEDYEQNWNTKHGSGALRELTRE 176
LRK KG GG+ + Y DL D L DP Y Q+ L ++
Sbjct 147 LRK---KGFGGNRFRDAPWDYNWTPYSDLMDALEADPCGKYSQS------------LLKK 191
Query 177 LNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYCCRDH 234
L GG T +D CG +G P+ +A G K +E +S R + ++
Sbjct 192 LVGGDFTP-IDQYMCGKNGKPIAEFAALMASEGITKLADVEAEVKSRTDSDRYI-VFKNK 249
Query 235 EHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTE 294
+ I W +R D +Y Q+ F + S + DT + + P+ F + S+++VI P +
Sbjct 250 LYRIVWNVQRKDVAYSKQSAFTMNSIVQLDTME-DVPRHSFTIGSEIQVIAPSTAVQANG 308
Query 295 GFMGRIRSVYPVASPQ---ECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVI 351
+ R +Y Q E N ++ S + C C + SW T + ++ CG
Sbjct 309 HLNLKQRLLYAFYGKQAVSEPNYIYHSAYVDCTSCGKGSWLTGNAVQGFACDCGAHYCAN 368
Query 352 E-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRT--RCFGG 408
+ + G + NAV+ CP +D E +H++ + + + G+T +GG
Sbjct 369 DVDLQSSGLVRKNAVLLTTCPCNKDGEC--KHTLPQLVSMMTDKCDVEVVGKTFILTYGG 426
Query 409 CVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRERVNI 461
++AY+GC +++PRA + I +G TG ET N L R + I
Sbjct 427 VIYAYMGCSGGTMHFIPRAKSCVSKIGDAIFTGCTGTWSKVCETANL----FLERAQHAI 482
Query 462 NIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAW 521
N V +F L E V +L+ ++S D ++ ++ + + G + VT G ++G
Sbjct 483 NFVNEFVLTETVVALLSGTTSSIEELRDLCRNATFEKVRDYLTPRG-WIVTMGSYIEGVI 541
Query 522 NIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLV 581
N+G +C A ++ S + + L + LD ++ V
Sbjct 542 NVGA-----AGVCNAALNAPFIVLSGLGESFKKVAATPWKLCSSLRETLDHYADSITYRV 596
Query 582 -------DAMVYTSDLLTNSVII--MAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIE 632
D YT+ LL +V+ AY V + + L+NL+ ++ + F ++
Sbjct 597 FPYDIPCDVTDYTALLLDCAVLTGASAYFVARYVDEKVEQLTNLVFSSCQSAVAAF--VQ 654
Query 633 AKLS---AGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMC 689
A +S A +F+ D + ++K + ++ V D +K F+ +++KA+++
Sbjct 655 ACMSTYKATAKFISDMFTLIKVVSERLYVYTSVGFVVVGDYSSQLLKQFMHILSKAMQLL 714
Query 690 IDQVTIAGAKLRSL--NLGEVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEVTFLE 743
V+ AG+KL S+ N + + S Y +G+ +Q L++P + K++ LE
Sbjct 715 HTTVSWAGSKLPSVVYNGRDSLVFPSGTYYCVSTQGRSLQDQFDLVIPGDLSKKQIGILE 774
Query 744 GDSHDTVLTSE------EVVLKNGELEALETPVDSFTNGAIVGTPVCV-NGLMLLEIKDK 796
+ T + + EVV+ G+LE P + +VG V + N + + ++D
Sbjct 775 PTPNSTTVDKKINTNVVEVVV--GQLE----PTKEHSPELVVGDYVIISNKIFVRSVEDS 828
Query 797 EQ--YCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL 854
E Y + G + +FRLKGGAP KGV FG + E+ ++V + +++ +D +L
Sbjct 829 ETVFYPLCTDGKIVPT-LFRLKGGAPPKGVKFGGEQTKEITAVRSVSVDYDVHPVLDALL 887
Query 855 -NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAG 913
+ + +TVE V +F VV + V++ L + G DL++++ Y+++ G
Sbjct 888 AGSELATFTVEKDLPVKDFVDVVKDEVIELLSKLLRGYNVDGFDLEDFADTPCYVYNAEG 947
Query 914 EENFSSRMYCSFYPPDEEEEDDAECEEEEI-DETCEHEYGTEDDYQGLPLEFGASAETVR 972
+ +SS M S P EE + EC+++ + DE E E+D + A+ E V
Sbjct 948 DLAWSSTMTFSVNP---VEEVEEECDDDYVEDEYLSEEMLVEEDEN----SWAAAVEAVI 1000
Query 973 VEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANP 1032
E+ + D L + SE P + V + T+ V + +++ +Q AN
Sbjct 1001 PMEDVQLDTLVAEIDVSE--------PADDVAEQAS----TEEVEVPSACVLEASQVANA 1048
Query 1033 MVIVN-----AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHN 1087
+ + +++I L A A + A ++ KL+ VG
Sbjct 1049 AEVESCEAEVSSSIPLHEDANAAKANDCAEGMPALDSTETVSKLSVDTPVG--------- 1099
Query 1088 LAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTV 1147
V + + + + + +S+ ++ P + P ++L V+ +
Sbjct 1100 ------DVTQDDATSSNATVISEDVHTATHSKGLVAVPEVV-------PEKALGTSVERM 1146
Query 1148 RTQVYIAVNDKALYEQ--VVMDYLDNLKP-RVEAPKQEEPPNTEDSKTEEKSVVQKPVDV 1204
R+ V + +L ++ V++ + KP RV+ PK E P V D
Sbjct 1147 RSTSEWTVVETSLKQETAVIVKNDSSAKPQRVKKPKAENPLKNFKHIVLNNDVTLVFGDA 1206
Query 1205 KPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVG 1264
+A D + T I + S +++ E ++ P VG
Sbjct 1207 IAVARATEDCILVNAANTHLKHG-----GGIAAAIDRASGGLVQAESDDYVNFYGPLNVG 1261
Query 1265 DV-------ITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEE 1317
D + +G I VV P +A ++L R K ++Y AG E
Sbjct 1262 DSTLLKGHGLATG-ILHVVGPDARANQDIQLLKRCYKAF--NKYPLVVSPLISAGIFCVE 1318
Query 1318 AKTALKKCKSA-----FYVLPSE-------APNAKEEI-LGTVSWNLREMLAHAEETRKL 1364
+ +L+ S + V+ SE AP + W R ++ +A+
Sbjct 1319 PRVSLEYLLSVVHTKTYVVVNSEKVYNDLAAPKPPTGLTYSHEGW--RGIIRNAKSFGFT 1376
Query 1365 MPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTM 1424
IC D A ++ + + + VD GV+++ Y+SK+P+ IIT N+ + + M
Sbjct 1377 CFICTDQSANAKLLKGRGVDLTKKTQTVD-GVKYYLYSSKDPLTDIITAANAC-KGICAM 1434
Query 1425 PIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLA 1484
PIGYVTHG +L +A + ++ + P V ++S D V N + + +T E+ F+ TV
Sbjct 1435 PIGYVTHGLDLAQAGQQVKKITVPYVCLLASKDQVPILNSDV--AVQTPEQSFINTVIAN 1492
Query 1485 GSYRDWSY-SGQRTELGVEF---LKRGDKIV------YHTLESPVEFHLDGEVLSLDKLK 1534
G Y W +G+ GV + L D+ + ++ ++ + D SL+K +
Sbjct 1493 GGYHCWHLVTGELIVKGVSYRKLLNWSDQTICYADNKFYVVKGQIALPFD----SLEKCR 1548
Query 1535 SLLSLR--EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEG 1592
+ L+ R + K + V T+D N T +++ + TY Q G + G+D++ P G
Sbjct 1549 TYLTSRAAQQKNVDVLVTIDGVNFRTVVLNNTTTYRVQLGSVFYKGSDISDTIPTEKMSG 1608
Query 1593 KTFFVLPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADN 1649
+ ++ +D+ +E E Y T D +FL RY S L KKWK+ G+ S+K N
Sbjct 1609 EAVYL--ADNLSEAEKAVLSEVYGTADTAFLHRYYSLLALVKKWKYTVHDGVKSLKLNSN 1666
Query 1650 NCYLSSVLLALQQL-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRET 1708
NCY++ +L L L E+KF PALQ AY + + GD+ F ALI+AY + T GE D
Sbjct 1667 NCYVNVTMLMLDMLKEIKFIVPALQAAYLKHKGGDSTEFIALIMAYGDCTYGEPDDASRL 1726
Query 1709 MTHLLQHANLES-AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ +L A L + AK V C CG + TT TG++A +Y+G S D L C CG
Sbjct 1727 LHTILSKAELTTQAKMVWRQWCNVCGVQDTTTTGLKACIYVGMNSLDELHATHEECCQCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTG-------NYQCGHYTHITAKE 1820
+ LV+ + ++++S + + +YT GHY H+ K+
Sbjct 1787 DVRKRQLVEHNAPWLLLSGLNEAKVMTPTSQSAGPDYTAFNVFQGVETSVGHYLHVRVKD 1846
Query 1821 TL-YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKK 1879
L Y+ D L+K S+ K +TDV+Y + Y+ V Y LDG T+ +++P L +Y K
Sbjct 1847 NLLYKYDSGSLSKTSDMKCKMTDVYYPKQRYSADCNVVVYSLDGNTWADVDPDLSAFYMK 1906
Query 1880 DNAYYTEQP-IDLVPTQPLPNASFDNFKL-----TCSNTKFADDLNQMTGF--TKPASRE 1931
D Y+T++P I+ P L + + N L T + + N + GF +KP S++
Sbjct 1907 DGKYFTKKPVIEYSPATILSGSVYTNSCLVGHDGTIGSDAISSSFNNLLGFDNSKPVSKK 1966
Query 1932 LSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLW 1991
L+ +FFPD GDV+ +Y Y +K GA L KPI+W N K N LR ++
Sbjct 1967 LTYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWVNNSKFDSALNKFNRATLRQVY 2026
Query 1992 STKPVDTSNSFEVLAVEDTQGMDNLAC-ESQQPTSE-EVVENPTIQKEVIECD-VKTTEV 2048
PV N + VL Q ++ A E +P S +V E+ + +I+C +K V
Sbjct 2027 DIAPVTLENKYTVLQDNQIQQVEVEAPKEDAKPQSPVQVAEDIDNKLPIIKCKGLKKPFV 2086
Query 2049 VGNVILKPSDEGVKVTQELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG---I 2104
+GV V LG +DL A YV+ N + + K N S + T+ I
Sbjct 2087 KDGYSFVNDPQGVNVIDTLGIDDLRALYVDRNLRLIVLKENNWSALFNIHTVEKGDLSVI 2146
Query 2105 AAINSVPWS-KILAYVKPFLGQAAITTSNCAK-------RLAQRVFNN--YMPYVFTLLF 2154
AA S+ KIL Q A T N R+ + V N + F LL
Sbjct 2147 AASGSITRRVKILLGASSLFAQFASVTVNVTTAMGKALGRMTRNVITNTGIIGQGFALLK 2206
Query 2155 QLC----TFTKSTN-SRIRASLPTTIAKNSVKS-VAKLCLDAGINYVKSPKFSKLFTIAM 2208
L TF KS N S ++ + V + V K C A + V KF ++ +
Sbjct 2207 MLLILPFTFWKSKNQSTVKVEVGALRTAGIVTTNVVKQCASAAYD-VLVVKFKRIDWKST 2265
Query 2209 WLLLLSIC------------------LGSLICVTAAFGVLL------SNFGAPSYCNGVR 2244
LL IC L S + + A G+L S G S C+G+
Sbjct 2266 LRLLFLICTTGLLLSSLYYLFLFHQVLTSDVMLDGAEGMLATYRELRSYLGIHSLCDGMV 2325
Query 2245 ELYLNSSNVTTMDFCEG-SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAE 2303
E Y N S DFC S C+ CL G DSL Y A + IQ ++SY +++ + E
Sbjct 2326 EAYRNVS-YDVNDFCSNRSALCNWCLIGQDSLTRYSAFQMIQTHVTSYVINIDWVWFVME 2384
Query 2304 WVLAYMLFTKFFYLLGLSAIMQVFFGYFAS--HFISNSWLMWFIISIVQMAPVSAMVRMY 2361
+ LAY+L+T F +L L Q FF Y + ++ S ++L+ V P+ +VR+Y
Sbjct 2385 FALAYVLYTSTFNVLLLVVSSQYFFSYTGAFVNWRSYNYLVSGYFFCVTHIPLLGLVRIY 2444
Query 2362 IFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGF 2421
F A +++ + Y H+++GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG F
Sbjct 2445 NFLACLWFLRRFYNHVINGCKDTACLLCYKRNRLTRVEASTVVCGSKRTFYIVANGGTSF 2504
Query 2422 CKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY 2481
C HNWNC++CDT G+TFI +EVA DL+ +R + PTD+S Y V+SV VK+ + L+
Sbjct 2505 CCRHNWNCVDCDTAGIGNTFICEEVANDLTTSLRRLVKPTDKSHYYVESVTVKDSVVQLH 2564
Query 2482 FDKAGQKTYERHPLSHFVNLDNLRAN---NTKGSLP-INVIVFDGKSKCDESASKSASVY 2537
+ + G YER+PL +F NLD L+ T +P N +++D + E+ ++SA VY
Sbjct 2565 YSREGASCYERYPLCYFTNLDKLKFKEVCKTPTGIPEHNFLIYDSSDRGQENLARSACVY 2624
Query 2538 YSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSEL 2597
YSQ++ +P+LL+D +V+ VGDS E++ KM D+YV++F + F V +KL LVATA +
Sbjct 2625 YSQVLSKPMLLVDSNMVTTVGDSREIASKMLDSYVNSFISLFGVNRDKLDKLVATARDCV 2684
Query 2598 AKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNK 2656
+G V+ TF AAR V++DV+T +++ L+ ++ DL++T + NN++ +Y K
Sbjct 2685 KRGDDFQTVIKTFTDAARGPAGVESDVETSSIVDALQYAYKHDLQLTTEGFNNYVPSYIK 2744
Query 2657 VENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIP 2716
+++ DLG ID NA +N ++ N + IWN DYM LS+ L++QIR A +K NIP
Sbjct 2745 PDSVATADLGCLIDLNAASVNQTSIRNANGACIWNSSDYMKLSDSLKRQIRIACRKCNIP 2804
Query 2717 FRLTCATTRQVVNVITTKIS---LKGG------KIVSTCFKLMLKATLLCVLAALVCYIV 2767
FRLT + R N+++ K S L GG K+ +K TL+ A++ Y+
Sbjct 2805 FRLTTSRLRSADNILSVKFSATKLSGGAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYLC 2864
Query 2768 MPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDK 2826
+P +S + + I+ YK +++G+ RDI +D CFANK+ F WF++ GG + ND
Sbjct 2865 LPAFNMSQVSFHEDRILTYKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGLFNNDI 2924
Query 2827 SCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFA 2886
SCPV A+I G VP LP V + + F+ RVF++ N+CYTP+ I Y F+
Sbjct 2925 SCPVTVAVIAGVAGARVPNLPANV-AWVGRQIVLFVSRVFASSNNVCYTPTAEIPYERFS 2983
Query 2887 TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNTY 2945
S CVLA+ECT+F+DA GK PYCYD +L G+ +Y +++P RY + D + I+FP
Sbjct 2984 DSGCVLASECTLFRDAEGKINPYCYDPTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEVV 3043
Query 2946 LEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIA 3005
E ++R+ T YCR G+CE + G+C++T+G W + N+HY GV+CG + +++
Sbjct 3044 FESTLRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIVR 3103
Query 3006 NIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMS 3065
+ L QPV +S S+ G ++ I +T A YY K +R +Y L++
Sbjct 3104 RLGLSLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALLN 3163
Query 3066 FTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCI 3125
LC V + L Y+ Y Y TFY T + +F+ H+ WF MF +VP W+ Y+ +
Sbjct 3164 SLCLCFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVGV 3223
Query 3126 SLKHCHWFFNNYLRKRV--MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ--Y 3181
L+H W + +K V +G +F++AA F++NK+ Y+ LR+ +TQ Y
Sbjct 3224 CLRHLLWVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS----ITQDSY 3279
Query 3182 NRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQS 3241
NRYL+++NKYKY+SGA+DT SYREA+ HL KAL +S +G+DVL+QPP S+TS+VLQS
Sbjct 3280 NRYLSMFNKYKYYSGAMDTASYREASAAHLCKALQVYSETGSDVLFQPPNCSVTSSVLQS 3339
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KMA PSG VE CMVQVTCG+ TLNGLWLD+ V+CPRHV+C A+ + +PNY+ LL+ K
Sbjct 3340 GLVKMAAPSGVVENCMVQVTCGSMTLNGLWLDNYVWCPRHVMCPADQLSDPNYDALLVSK 3399
Query 3302 SNHSFLVQ---AGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
+N SF+VQ LRV+GH+M LL+L V+++NP+TP Y F ++PG +FSVLACY
Sbjct 3400 TNLSFIVQKNVGAPANLRVVGHTMVGTLLKLTVESANPQTPAYTFTTVKPGASFSVLACY 3459
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P+GV+ MR N TIKGSFL GSCGSVG+ + + ++FCYMH MEL G H G +
Sbjct 3460 NGRPTGVFMVNMRQNSTIKGSFLCGSCGSVGYTQEGNVINFCYMHQMELSNGTHTGCAFD 3519
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G YG F DRQ Q +D T+N++AWLYAA++NG WF+ T + FN AM
Sbjct 3520 GVMYGAFEDRQVHQVQLSDKYCTINIVAWLYAAILNGCNWFVKPNKTGIATFNEWAMSNQ 3579
Query 3479 Y-EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ E + VD+L + +TG++V + A+ + L G G+TILG+++LEDEFTP DV
Sbjct 3580 FTEFIGTQSVDML---AHKTGVSVEQLLYAI-QTLHKGFQGKTILGNSMLEDEFTPDDVN 3635
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA 3597
Q GV Q K+I G HW+ T L + + +Q T+++++ +++E L T ++
Sbjct 3636 MQVMGVVMQSGVKRISYGLVHWLFTTLLLAYVATLQLTKFTIWNYLFEVIPLQLTPLVLC 3695
Query 3598 IAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMP----ASWVMRIMTWLELADTSLSG 3653
+ AC ML VKHKH FL LFLLP+ + Y N+VY P +S ++ + WL A +
Sbjct 3696 VMACVMLTVKHKHTFLTLFLLPTAICLTYANIVYEPQTPVSSALIAVANWLNPASVYMRT 3755
Query 3654 YRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWAL 3713
D +Y S L ++ R +A+ L + + Y G+ ++
Sbjct 3756 TH-TDLGVYLSLCFALAVVVRRLYRPNASNLALALGSAMVWFYTYTTGDC-SSPLTYLMF 3813
Query 3714 VISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGL 3773
+ ++TS+Y+ V + +A+ V Y P ++ ++L+Y +GY C YFG+
Sbjct 3814 LTTLTSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYLAVGYFCTVYFGV 3873
Query 3774 FCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVA 3833
F LLN R+ LGVYDY VSTQEFRY+ GL P++S +A +LN+KL+GIGG PCIK+A
Sbjct 3874 FSLLNLKLRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIA 3933
Query 3834 TVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLS 3893
+VQSK++D+KCTSVVLLSVLQQL +E++SK WA CV+LHNDIL A D TEAF+ V L +
Sbjct 3934 SVQSKLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFA 3993
Query 3894 VLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEV 3952
L+S VD+ L ++LD+ + LQA SEFS L SYA AQ +Y++A+ +GD S
Sbjct 3994 TLMSFSANVDLEALASDLLDHPSVLQATLSEFSHLASYAELEAAQSSYQKALNSGDASPQ 4053
Query 3953 VLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFT 4012
VLK L+K++N+AK+ +++D A+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF
Sbjct 4054 VLKALQKAVNIAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFG 4113
Query 4013 MLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASAL 4072
M++KLDND LN +I+NAR+GCVPL+++PL + KL VV+PD + + +YA AL
Sbjct 4114 MIKKLDNDVLNGVISNARNGCVPLSVVPLCASNKLRVVIPDITIWNKVVTWPSLSYAGAL 4173
Query 4073 WEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSC 4131
W+I + + D ++V+ S++ N +L WPL++ R A+SAV LQNNE+ P L+ M
Sbjct 4174 WDISLINNVDGEVVKSSDVTETNE-SLTWPLVLECTRAASSAVTLQNNEIRPSGLKTMVV 4232
Query 4132 AAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCR 4191
+AG C + ++LAYY +G + ++ +LS++ LKWA+ DG I EL+PPC+
Sbjct 4233 SAGIDHANC-NTSSLAYYEPVEGRKMLMGILSENAHLKWAKVEGRDGFVNI--ELQPPCK 4289
Query 4192 FVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAV 4251
F+ PKGP+V+YLYF+K LNNL+RG +LG +AATVRLQAG+ TE NS+VLS F+V
Sbjct 4290 FLIAGPKGPEVRYLYFVKNLNNLHRGQLLGHIAATVRLQAGSNTEFAINSSVLSAVTFSV 4349
Query 4252 DPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHI 4311
DP KAY D++ +GG P+TNCVKML TGTG A++V PEAN DQ+++GGAS CLYCR HI
Sbjct 4350 DPGKAYLDFVNAGGAPLTNCVKMLTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHI 4409
Query 4312 DHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSA 4371
+HP+ G C KGK+VQ+P DPVGF L+NT C VC W G+GC+CD LR + +
Sbjct 4410 EHPDVTGVCKFKGKFVQVPLHI-RDPVGFCLQNTPCNVCQFWIGHGCNCDALRGTTIPQS 4468
Query 4372 DASTFLN 4378
S FLN
Sbjct 4469 KDSNFLN 4475
>sp|P0C6W4|R1AB_BCHK5 Replicase polyprotein 1ab OS=Bat coronavirus
HKU5 OX=694008 GN=rep PE=3 SV=1
Length=7182
Score = 2335 bits (6051), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1545/4566 (34%), Positives = 2379/4566 (52%), Gaps = 318/4566 (7%)
Query 13 HVQLSLPVLQVRDVLVR---GFGDSVEEALSEAREHLKNGTCGLV--ELEKGVLPQLEQP 67
HV L + D++++ F D E A E L G+ L + KG + L P
Sbjct 28 HVSLKASLCDAGDLVLKISPWFMDG-ESAYKHVSEQLSKGSKLLFVPQTLKGFIRHLPGP 86
Query 68 YVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITL-----GVLVPHVGETPIAYRNVL 122
V++ T +V +A + G G TL G+ P + L
Sbjct 87 RVYLVERLTGGTYSDPFMVNQLAYQNAAGEGVIGTTLQGKRVGMFFPFDADLVTGEFQFL 146
Query 123 LRKNGNKGAGGHSYGIDLKSY------DLGDELGTDPIEDYEQNWNTKHGSGALRELTRE 176
LRK KG GG+ + Y DL D L DP Y Q+ L ++
Sbjct 147 LRK---KGFGGNRFRDAPWDYNWTPYSDLMDALEADPCGKYSQS------------LLKK 191
Query 177 LNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYCCRDH 234
L GG T +D CG +G P+ +A G K +E +S R + ++
Sbjct 192 LVGGDFTP-IDQYMCGKNGKPIAEFAALMASEGITKLADVEAEVKSRTDSDRYI-VFKNK 249
Query 235 EHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTE 294
+ I W +R D +Y Q+ F + S + DT + + P+ F + S+++VI P +
Sbjct 250 LYRIVWNVQRKDVAYSKQSAFTMNSIVQLDTME-DVPRHSFTIGSEIQVIAPSTAVQANG 308
Query 295 GFMGRIRSVYPVASPQ---ECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVI 351
+ R +Y Q E N ++ S + C C + SW T + ++ CG
Sbjct 309 HLNLKQRLLYAFYGKQAVSEPNYIYHSAYVDCTSCGKGSWLTGNAVQGFACDCGAHYCAN 368
Query 352 E-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRT--RCFGG 408
+ + G + NAV+ CP +D E +H++ + + + G+T +GG
Sbjct 369 DVDLQSSGLVRKNAVLLTTCPCNKDGEC--KHTLPQLVSMMTDKCDVEVVGKTFILTYGG 426
Query 409 CVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRERVNI 461
++AY+GC +++PRA + I +G TG ET N L R + I
Sbjct 427 VIYAYMGCSGGTMHFIPRAKSCVSKIGDAIFTGCTGTWSKVCETANL----FLERAQHAI 482
Query 462 NIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAW 521
N V +F L E V +L+ ++S D ++ ++ + + G + VT G ++G
Sbjct 483 NFVNEFVLTETVVALLSGTTSSIEELRDLCRNATFEKVRDYLTPRG-WIVTMGSYIEGVI 541
Query 522 NIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLV 581
N+G +C A ++ S + + L + LD ++ V
Sbjct 542 NVGA-----AGVCNAALNAPFIVLSGLGESFKKVAATPWKLCSSLRETLDHYADSITYRV 596
Query 582 -------DAMVYTSDLLTNSVII--MAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIE 632
D YT+ LL +V+ AY V + + L+NL+ ++ + F ++
Sbjct 597 FPYDIPCDVTDYTALLLDCAVLTGASAYFVARYVDEKVEQLTNLVFSSCQSAVAAF--VQ 654
Query 633 AKLS---AGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMC 689
A +S A +F+ D + ++K + ++ V D +K F+ +++KA+++
Sbjct 655 ACMSTYKATAKFISDMFTLIKVVSERLYVYTSVGFVVVGDYSSQLLKQFMHILSKAMQLL 714
Query 690 IDQVTIAGAKLRSL--NLGEVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEVTFLE 743
V+ AG+KL S+ N + + S Y +G+ +Q L++P + K++ LE
Sbjct 715 HTTVSWAGSKLPSVVYNGRDSLVFPSGTYYCVSTQGRSLQDQFDLVIPGDLSKKQIGILE 774
Query 744 GDSHDTVLTSE------EVVLKNGELEALETPVDSFTNGAIVGTPVCV-NGLMLLEIKDK 796
+ T + + EVV+ G+LE P + +VG V + N + + ++D
Sbjct 775 PTPNSTTVDKKINTNVVEVVV--GQLE----PTKEHSPELVVGDYVIISNKIFVRSVEDS 828
Query 797 EQ--YCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL 854
E Y + G + +FRLKGGAP KGV FG + E+ ++V + +++ +D +L
Sbjct 829 ETVFYPLCTDGKIVPT-LFRLKGGAPPKGVKFGGEQTKEITAVRSVSVDYDVHPVLDALL 887
Query 855 -NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAG 913
+ + +TVE V +F VV + V++ L + G DL++++ Y+++ G
Sbjct 888 AGSELATFTVEKDLPVKDFVDVVKDEVIELLSKLLRGYNVDGFDLEDFADTPCYVYNAEG 947
Query 914 EENFSSRMYCSFYPPDEEEE--DDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETV 971
+ +SS M S P +E EE DD E+E + E E E+D + A+ E V
Sbjct 948 DLAWSSTMTFSVNPVEEVEEECDDDYVEDEYLSE----EMLVEEDEN----SWAAAVEAV 999
Query 972 RVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSAN 1031
E+ + D L + SE P + V + T+ V + +++ +Q AN
Sbjct 1000 IPMEDVQLDTLVAEIDVSE--------PADDVAEQAS----TEEVEVPSACVLEASQVAN 1047
Query 1032 PMVIVN-----AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGH 1086
+ + +++I L A A + A ++ KL+ VG
Sbjct 1048 AAEVESCEAEVSSSIPLHEDANAAKANDCAEGMPALDSTETVSKLSVDTPVG-------- 1099
Query 1087 NLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQT 1146
V + + + + + +S+ ++ P + P ++L V+
Sbjct 1100 -------DVTQDDATSSNATVISEDVHTATHSKGLVAVPEVV-------PEKALGTSVER 1145
Query 1147 VRTQVYIAVNDKALYEQ--VVMDYLDNLKP-RVEAPKQEEPPNTEDSKTEEKSVVQKPVD 1203
+R+ V + +L ++ V++ + KP RV+ PK E P V D
Sbjct 1146 MRSTSEWTVVETSLKQETAVIVKNDSSAKPQRVKKPKAENPLKNFKHIVLNNDVTLVFGD 1205
Query 1204 VKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMV 1263
+A D + T L I + S +++ E ++ P V
Sbjct 1206 AIAVARATEDCILVNAANTH-----LKHGGGIAAAIDRASGGLVQAESDDYVNFYGPLNV 1260
Query 1264 GDV-------ITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLE 1316
GD + +G I VV P +A ++L R K ++Y AG
Sbjct 1261 GDSTLLKGHGLATG-ILHVVGPDARANQDIQLLKRCYKAF--NKYPLVVSPLISAGIFCV 1317
Query 1317 EAKTALKKCKSA-----FYVLPSE-------APNAKEEI-LGTVSWNLREMLAHAEETRK 1363
E + +L+ S + V+ SE AP + W R ++ +A+
Sbjct 1318 EPRVSLEYLLSVVHTKTYVVVNSEKVYNDLAAPKPPTGLTYSHEGW--RGIIRNAKSFGF 1375
Query 1364 LMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVT 1423
IC D A ++ + + + VD GV+++ Y+SK+P+ IIT N+ + +
Sbjct 1376 TCFICTDQSANAKLLKGRGVDLTKKTQTVD-GVKYYLYSSKDPLTDIITAANAC-KGICA 1433
Query 1424 MPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSL 1483
MPIGYVTHG +L +A + ++ + P V ++S D V N + + +T E+ F+ TV
Sbjct 1434 MPIGYVTHGLDLAQAGQQVKKITVPYVCLLASKDQVPILNSDV--AVQTPEQSFINTVIA 1491
Query 1484 AGSYRDWSY-SGQRTELGVEF---LKRGDKIV------YHTLESPVEFHLDGEVLSLDKL 1533
G Y W +G+ GV + L D+ + ++ ++ + D SL+K
Sbjct 1492 NGGYHCWHLVTGELIVKGVSYRKLLNWSDQTICYADNKFYVVKGQIALPFD----SLEKC 1547
Query 1534 KSLLSLR--EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHE 1591
++ L+ R + K + V T+D N T +++ + TY Q G + G+D++ P
Sbjct 1548 RTYLTSRAAQQKNVDVLVTIDGVNFRTVVLNNTTTYRVQLGSVFYKGSDISDTIPTEKMS 1607
Query 1592 GKTFFVLPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWAD 1648
G+ ++ +D+ +E E Y T D +FL RY S L KKWK+ G+ S+K
Sbjct 1608 GEAVYL--ADNLSEAEKAVLSEVYGTADTAFLHRYYSLLALVKKWKYTVHDGVKSLKLNS 1665
Query 1649 NNCYLSSVLLALQQL-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
NNCY++ +L L L E+KF PALQ AY + + GD+ F ALI+AY + T GE D
Sbjct 1666 NNCYVNVTMLMLDMLKEIKFIVPALQAAYLKHKGGDSTEFIALIMAYGDCTYGEPDDASR 1725
Query 1708 TMTHLLQHANLES-AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC 1766
+ +L A L + AK V C CG + TT TG++A +Y+G S D L C C
Sbjct 1726 LLHTILSKAELTTQAKMVWRQWCNVCGVQDTTTTGLKACIYVGMNSLDELHATHEECCQC 1785
Query 1767 GRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTG-------NYQCGHYTHITAK 1819
G + LV+ + ++++S + + +YT GHY H+ K
Sbjct 1786 GDVRKRQLVEHNAPWLLLSGLNEAKVMTPTSQSAGPDYTAFNVFQGVETSVGHYLHVRVK 1845
Query 1820 ETL-YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYK 1878
+ L Y+ D L+K S+ K +TDV+Y + Y+ V Y LDG T+ +++P L +Y
Sbjct 1846 DNLLYKYDSGSLSKTSDMKCKMTDVYYPKQRYSADCNVVVYSLDGNTWADVDPDLSAFYM 1905
Query 1879 KDNAYYTEQP-IDLVPTQPLPNASFDNFKL-----TCSNTKFADDLNQMTGF--TKPASR 1930
KD Y+T++P I+ P L + + N L T + + N + GF +KP S+
Sbjct 1906 KDGKYFTKKPVIEYSPATILSGSVYTNSCLVGHDGTIGSDAISSSFNNLLGFDNSKPVSK 1965
Query 1931 ELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCL 1990
+L+ +FFPD GDV+ +Y Y +K GA L KPI+W N K N LR +
Sbjct 1966 KLTYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWVNNSKFDSALNKFNRATLRQV 2025
Query 1991 WSTKPVDTSNSFEVLAVEDTQGMDNLAC-ESQQPTSE-EVVENPTIQKEVIECD-VKTTE 2047
+ PV N + VL Q ++ A E +P S +V E+ + +I+C +K
Sbjct 2026 YDIAPVTLENKYTVLQDNQIQQVEVEAPKEDAKPQSPVQVAEDIDNKLPIIKCKGLKKPF 2085
Query 2048 VVGNVILKPSDEGVKVTQELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG--- 2103
V +GV V LG +DL A YV+ N + + K N S + T+
Sbjct 2086 VKDGYSFVNDPQGVNVIDTLGIDDLRALYVDRNLRLIVLKENNWSALFNIHTVEKGDLSV 2145
Query 2104 IAAINSVPWS-KILAYVKPFLGQAAITTSNCAK-------RLAQRVFNN--YMPYVFTLL 2153
IAA S+ KIL Q A T N R+ + V N + F LL
Sbjct 2146 IAASGSITRRVKILLGASSLFAQFASVTVNVTTAMGKALGRMTRNVITNTGIIGQGFALL 2205
Query 2154 FQLC----TFTKSTN-SRIRASLPTTIAKNSVKS-VAKLCLDAGINYVKSPKFSKLFTIA 2207
L TF KS N S ++ + V + V K C A + V KF ++ +
Sbjct 2206 KMLLILPFTFWKSKNQSTVKVEVGALRTAGIVTTNVVKQCASAAYD-VLVVKFKRIDWKS 2264
Query 2208 MWLLLLSIC------------------LGSLICVTAAFGVLL------SNFGAPSYCNGV 2243
LL IC L S + + A G+L S G S C+G+
Sbjct 2265 TLRLLFLICTTGLLLSSLYYLFLFHQVLTSDVMLDGAEGMLATYRELRSYLGIHSLCDGM 2324
Query 2244 RELYLNSSNVTTMDFCEG-SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAA 2302
E Y N S DFC S C+ CL G DSL Y A + IQ ++SY +++ +
Sbjct 2325 VEAYRNVS-YDVNDFCSNRSALCNWCLIGQDSLTRYSAFQMIQTHVTSYVINIDWVWFVM 2383
Query 2303 EWVLAYMLFTKFFYLLGLSAIMQVFFGYFAS--HFISNSWLMWFIISIVQMAPVSAMVRM 2360
E+ LAY+L+T F +L L Q FF Y + ++ S ++L+ V P+ +VR+
Sbjct 2384 EFALAYVLYTSTFNVLLLVVSSQYFFSYTGAFVNWRSYNYLVSGYFFCVTHIPLLGLVRI 2443
Query 2361 YIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRG 2420
Y F A +++ + Y H+++GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG
Sbjct 2444 YNFLACLWFLRRFYNHVINGCKDTACLLCYKRNRLTRVEASTVVCGSKRTFYIVANGGTS 2503
Query 2421 FCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHL 2480
FC HNWNC++CDT G+TFI +EVA DL+ +R + PTD+S Y V+SV VK+ + L
Sbjct 2504 FCCRHNWNCVDCDTAGIGNTFICEEVANDLTTSLRRLVKPTDKSHYYVESVTVKDSVVQL 2563
Query 2481 YFDKAGQKTYERHPLSHFVNLDNLRAN---NTKGSLP-INVIVFDGKSKCDESASKSASV 2536
++ + G YER+PL +F NLD L+ T +P N +++D + E+ ++SA V
Sbjct 2564 HYSREGASCYERYPLCYFTNLDKLKFKEVCKTPTGIPEHNFLIYDSSDRGQENLARSACV 2623
Query 2537 YYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSE 2596
YYSQ++ +P+LL+D +V+ VGDS E++ KM D+YV++F + F V +KL LVATA
Sbjct 2624 YYSQVLSKPMLLVDSNMVTTVGDSREIASKMLDSYVNSFISLFGVNRDKLDKLVATARDC 2683
Query 2597 LAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYN 2655
+ +G V+ TF AAR V++DV+T +++ L+ ++ DL++T + NN++ +Y
Sbjct 2684 VKRGDDFQTVIKTFTDAARGPAGVESDVETSSIVDALQYAYKHDLQLTTEGFNNYVPSYI 2743
Query 2656 KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNI 2715
K +++ DLG ID NA +N ++ N + IWN DYM LS+ L++QIR A +K NI
Sbjct 2744 KPDSVATADLGCLIDLNAASVNQTSIRNANGACIWNSSDYMKLSDSLKRQIRIACRKCNI 2803
Query 2716 PFRLTCATTRQVVNVITTKIS---LKGG------KIVSTCFKLMLKATLLCVLAALVCYI 2766
PFRLT + R N+++ K S L GG K+ +K TL+ A++ Y+
Sbjct 2804 PFRLTTSRLRSADNILSVKFSATKLSGGAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYL 2863
Query 2767 VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKND 2825
+P +S + + I+ YK +++G+ RDI +D CFANK+ F WF++ GG + ND
Sbjct 2864 CLPAFNMSQVSFHEDRILTYKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGLFNND 2923
Query 2826 KSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDF 2885
SCPV A+I G VP LP V + + F+ RVF++ N+CYTP+ I Y F
Sbjct 2924 ISCPVTVAVIAGVAGARVPNLPANV-AWVGRQIVLFVSRVFASSNNVCYTPTAEIPYERF 2982
Query 2886 ATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNT 2944
+ S CVLA+ECT+F+DA GK PYCYD +L G+ +Y +++P RY + D + I+FP
Sbjct 2983 SDSGCVLASECTLFRDAEGKINPYCYDPTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEV 3042
Query 2945 YLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLI 3004
E ++R+ T YCR G+CE + G+C++T+G W + N+HY GV+CG + +++
Sbjct 3043 VFESTLRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIV 3102
Query 3005 ANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLM 3064
+ L QPV +S S+ G ++ I +T A YY K +R +Y L+
Sbjct 3103 RRLGLSLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALL 3162
Query 3065 SFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFC 3124
+ LC V + L Y+ Y Y TFY T + +F+ H+ WF MF +VP W+ Y+
Sbjct 3163 NSLCLCFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVG 3222
Query 3125 ISLKHCHWFFNNYLRKRV--MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
+ L+H W + +K V +G +F++AA F++NK+ Y+ LR+ + YN
Sbjct 3223 VCLRHLLWVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS--ITQDSYN 3280
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSG 3242
RYL+++NKYKY+SGA+DT SYREA+ HL KAL +S +G+DVL+QPP S+TS+VLQSG
Sbjct 3281 RYLSMFNKYKYYSGAMDTASYREASAAHLCKALQVYSETGSDVLFQPPNCSVTSSVLQSG 3340
Query 3243 FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKS 3302
KMA PSG VE CMVQVTCG+ TLNGLWLD+ V+CPRHV+C A+ + +PNY+ LL+ K+
Sbjct 3341 LVKMAAPSGVVENCMVQVTCGSMTLNGLWLDNYVWCPRHVMCPADQLSDPNYDALLVSKT 3400
Query 3303 NHSFLVQ---AGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
N SF+VQ LRV+GH+M LL+L V+++NP+TP Y F ++PG +FSVLACYN
Sbjct 3401 NLSFIVQKNVGAPANLRVVGHTMVGTLLKLTVESANPQTPAYTFTTVKPGASFSVLACYN 3460
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
G P+GV+ MR N TIKGSFL GSCGSVG+ + + ++FCYMH MEL G H G +G
Sbjct 3461 GRPTGVFMVNMRQNSTIKGSFLCGSCGSVGYTQEGNVINFCYMHQMELSNGTHTGCAFDG 3520
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
YG F DRQ Q +D T+N++AWLYAA++NG WF+ T + FN AM +
Sbjct 3521 VMYGAFEDRQVHQVQLSDKYCTINIVAWLYAAILNGCNWFVKPNKTGIATFNEWAMSNQF 3580
Query 3480 -EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
E + VD+L + +TG++V + A+ + L G G+TILG+++LEDEFTP DV
Sbjct 3581 TEFIGTQSVDML---AHKTGVSVEQLLYAI-QTLHKGFQGKTILGNSMLEDEFTPDDVNM 3636
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q GV Q K+I G HW+ T L + + +Q T+++++ +++E L T ++ +
Sbjct 3637 QVMGVVMQSGVKRISYGLVHWLFTTLLLAYVATLQLTKFTIWNYLFEVIPLQLTPLVLCV 3696
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMP----ASWVMRIMTWLELADTSLSGY 3654
AC ML VKHKH FL LFLLP+ + Y N+VY P +S ++ + WL A +
Sbjct 3697 MACVMLTVKHKHTFLTLFLLPTAICLTYANIVYEPQTPVSSALIAVANWLNPASVYMRTT 3756
Query 3655 RLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALV 3714
D +Y S L ++ R +A+ L + + Y G+ ++ +
Sbjct 3757 H-TDLGVYLSLCFALAVVVRRLYRPNASNLALALGSAMVWFYTYTTGDC-SSPLTYLMFL 3814
Query 3715 ISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLF 3774
++TS+Y+ V + +A+ V Y P ++ ++L+Y +GY C YFG+F
Sbjct 3815 TTLTSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYLAVGYFCTVYFGVF 3874
Query 3775 CLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVAT 3834
LLN R+ LGVYDY VSTQEFRY+ GL P++S +A +LN+KL+GIGG PCIK+A+
Sbjct 3875 SLLNLKLRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIAS 3934
Query 3835 VQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSV 3894
VQSK++D+KCTSVVLLSVLQQL +E++SK WA CV+LHNDIL A D TEAF+ V L +
Sbjct 3935 VQSKLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFAT 3994
Query 3895 LLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVV 3953
L+S VD+ L ++LD+ + LQA SEFS L SYA AQ +Y++A+ +GD S V
Sbjct 3995 LMSFSANVDLEALASDLLDHPSVLQATLSEFSHLASYAELEAAQSSYQKALNSGDASPQV 4054
Query 3954 LKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTM 4013
LK L+K++N+AK+ +++D A+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M
Sbjct 4055 LKALQKAVNIAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGM 4114
Query 4014 LRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALW 4073
++KLDND LN +I+NAR+GCVPL+++PL + KL VV+PD + + +YA ALW
Sbjct 4115 IKKLDNDVLNGVISNARNGCVPLSVVPLCASNKLRVVIPDITIWNKVVTWPSLSYAGALW 4174
Query 4074 EIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSCA 4132
+I + + D ++V+ S++ N +L WPL++ R A+SAV LQNNE+ P L+ M +
Sbjct 4175 DISLINNVDGEVVKSSDVTETNE-SLTWPLVLECTRAASSAVTLQNNEIRPSGLKTMVVS 4233
Query 4133 AGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRF 4192
AG C + ++LAYY +G + ++ +LS++ LKWA+ DG I EL+PPC+F
Sbjct 4234 AGIDHANC-NTSSLAYYEPVEGRKMLMGILSENAHLKWAKVEGRDGFVNI--ELQPPCKF 4290
Query 4193 VTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVD 4252
+ PKGP+V+YLYF+K LNNL+RG +LG +AATVRLQAG+ TE NS+VLS F+VD
Sbjct 4291 LIAGPKGPEVRYLYFVKNLNNLHRGQLLGHIAATVRLQAGSNTEFAINSSVLSAVTFSVD 4350
Query 4253 PAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHID 4312
P KAY D++ +GG P+TNCVKML TGTG A++V PEAN DQ+++GGAS CLYCR HI+
Sbjct 4351 PGKAYLDFVNAGGAPLTNCVKMLTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIE 4410
Query 4313 HPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSAD 4372
HP+ G C KGK+VQ+P DPVGF L+NT C VC W G+GC+CD LR + +
Sbjct 4411 HPDVTGVCKFKGKFVQVPLH-IRDPVGFCLQNTPCNVCQFWIGHGCNCDALRGTTIPQSK 4469
Query 4373 ASTFLN 4378
S FLN
Sbjct 4470 DSNFLN 4475
>sp|P0C6T6|R1A_BCHK9 Replicase polyprotein 1a OS=Bat coronavirus
HKU9 OX=694006 GN=1a PE=3 SV=1
Length=4248
Score = 2294 bits (5945), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1257/3110 (40%), Positives = 1831/3110 (59%), Gaps = 158/3110 (5%)
Query 1343 ILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDY-GVRFFFY 1401
++ VS + M+ +E L+P+ +D A + ++R +EG+ G F+ Y
Sbjct 1216 LVDVVSMSFSAMVNFGKEKGLLIPVVIDYPAFLKVLKR----FSPKEGLFSSNGYEFYGY 1271
Query 1402 TSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTT 1461
+ +P+ + LNSL PL+ +P G++ +G L +A MR L P V V S +V
Sbjct 1272 SRDKPLHEVSKDLNSLGRPLIMIPFGFIVNGQTLAVSAVSMRGLTVPHTVVVPSESSVPL 1331
Query 1462 YNGYLT---SSSKTSEEHFVETVSLAGSYRDWSYSGQRTELGVE------FLKRGDKIVY 1512
Y Y S T+ + FV + L G+ RDW +T V+ KRG+ Y
Sbjct 1332 YRAYFNGVFSGDTTAVQDFVVDILLNGA-RDWDV--LQTTCTVDRKVYKTICKRGN--TY 1386
Query 1513 HTLESPVEFHLDGEVL----SLDKLKSLLSLR---EVKTIKVFTTVDNTNLHTQLVDMSM 1565
+ + + G+V+ ++ K ++ L + IKV TTVD N T LV +
Sbjct 1387 LCFDDTNLYAITGDVVLKFATVSKARAYLETKLCAPEPLIKVLTTVDGINYSTVLVSTAQ 1446
Query 1566 TYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF-EYYHTLDESFLGRYM 1624
+Y Q G + DG D + P EG + + + A EYY D + + R M
Sbjct 1447 SYRAQIGTVFCDGHDWSNKNPMPTDEGTHLYKQDNFSSAEVTAIREYYGVDDSNIIARAM 1506
Query 1625 SALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDA 1684
S + W + V G + D+NCYL+ + LQ ++V F+ P + AY + G+
Sbjct 1507 SIRKTVQTWPYTVVDGRVLLAQRDSNCYLNVAISLLQDIDVSFSTPWVCRAYDALKGGNP 1566
Query 1685 ANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEA 1744
+++A T G D ++ +L H + +A+RV+ VC+HCG TG +A
Sbjct 1567 LPMAEVLIALGKATPGVSDDAHMVLSAVLNHGTV-TARRVMQTVCEHCGVSQMVFTGTDA 1625
Query 1745 VMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQ-QGTFLCANE 1803
+ G++ D+L VS+ C CGR A +Y+ +Q+S +++MS P + L G + A
Sbjct 1626 CTFYGSVVLDDLYAPVSVVCQCGRPAIRYVSEQKSPWLLMSCTPTQVPLDTSGIWKTAIV 1685
Query 1804 YTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDG 1863
+ G GHY + + D + S+ K P TD+ Y TS+T+ K +Y LDG
Sbjct 1686 FRGPVTAGHYMYAVNGTLISVYDANTRRRTSDLKLPATDILYGPTSFTSDSKVETYYLDG 1745
Query 1864 VTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLT-CSNTKFADDLNQMT 1922
V T I+P Y K+ + Y+T PI++V P S+D F L+ C N + A+ N+
Sbjct 1746 VKRTTIDPDFSKYVKRGDYYFTTAPIEVV-AAPKLVTSYDGFYLSSCQNPQLAESFNKAI 1804
Query 1923 GFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKP 1982
TK +L +T +P++ GDVVAI + A G+ + KP+++ +P
Sbjct 1805 NATKTGPMKL-LTMYPNVAGDVVAISDDNVVAH-PYGSLHMGKPVLF---------VTRP 1853
Query 1983 NTWC-LRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIEC 2041
NTW L L ST V+T N+++VLAV+ P + E E P K I
Sbjct 1854 NTWKKLVPLLSTVVVNTPNTYDVLAVDPL------------PVNNETSEEPISVKAPIPL 1901
Query 2042 -DVKTTEVVGNVILKPSDEG-VKVTQELGHEDLMAAYVENTS-ITIKKPNELSLALGLKT 2098
+K T V+ P ++G + +E DL YVE + K + LS LGL+
Sbjct 1902 YGLKATMVLNGTTYVPGNKGHLLCLKEFTLTDLQTFYVEGVQPFVLLKASHLSKVLGLRV 1961
Query 2099 IATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTL-LFQLC 2157
+ +N + + AY A RL RV + + + T + +
Sbjct 1962 --SDSSLHVNHLSKGVVYAYA--------------ATRLTTRVTTSLLGGLVTRSVRKTA 2005
Query 2158 TFTKSTNS------------RIRASLPTTIAKNSVKSVAKL-CLDAG-------INYVKS 2197
F +STN ++ + K + V+ + + G +NY++S
Sbjct 2006 DFVRSTNPGSKCVGLLCLFYQLFMRFWLLVKKPPIVKVSGIIAYNTGCGVTTCVLNYLRS 2065
Query 2198 -------PKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELY--L 2248
+ KL +++ + CL IC GV LS APS + +
Sbjct 2066 RCGNISWSRLLKLLRYMLYIWFVWTCL--TIC-----GVWLSEPYAPSLVTRFKYFLGIV 2118
Query 2249 NSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAY 2308
+ ++ + +C++G+DSLD YPAL Q S + T + + E AY
Sbjct 2119 MPCDYVLVNETGTGWLHHLCMAGMDSLD-YPALRMQQHRYGS-PYNYTYILMLLEAFFAY 2176
Query 2309 MLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFY 2368
+L+T ++G+ A++ + Y + NSWL+ F+ I+++ P ++M+RMYI A +
Sbjct 2177 LLYTPALPIVGILAVLHLIVLYLPIP-LGNSWLVVFLYYIIRLVPFTSMLRMYIVIAFLW 2235
Query 2369 YIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWN 2428
+K ++H+ GC + C+MCYK+N A R+EC+T+VNG+KR FYV ANGG FC HNWN
Sbjct 2236 LCYKGFLHVRYGCNNVACLMCYKKNVAKRIECSTVVNGVKRMFYVNANGGTHFCTKHNWN 2295
Query 2429 CLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQK 2488
C++CDT+ STFI +VA DLS QFKRPI TD++ Y V SV V+NG ++ YF+ GQ+
Sbjct 2296 CVSCDTYTVDSTFICRQVALDLSAQFKRPIIHTDEAYYEVTSVEVRNGYVYCYFESDGQR 2355
Query 2489 TYERHPLSHFVNLDNLRANNTKGSLP-INVIVFDGKSKCDESASKSASVYYSQLMCQPIL 2547
+YER P+ F N+ L + KG+ P NV+VFD ++ +E+A K+A++YY+QL C+PIL
Sbjct 2356 SYERFPMDAFTNVSKLHYSELKGAAPAFNVLVFDATNRIEENAVKTAAIYYAQLACKPIL 2415
Query 2548 LLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVL 2607
L+D+ +V VGD ++ MF+AY + +S+ M+K+K L +TA +++ G+ ++ VL
Sbjct 2416 LVDKRMVGVVGDDATIARAMFEAYAQNYLLKYSIAMDKVKHLYSTALQQISSGMTVESVL 2475
Query 2608 STFVSAARQGVVD--TDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDL 2665
FV + R D +DVDT D++ C++L H E T DS NN + TY K + ++ ++
Sbjct 2476 KVFVGSTRAEAKDLESDVDTNDLVSCIRLCHQEGWEWTTDSWNNLVPTYIKQDTLSTLEV 2535
Query 2666 GACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTR 2725
G + NA+++NA +AK V+LIW D++ LSE +R+Q++ AA+K + +T ++ +
Sbjct 2536 GQFMTANAKYVNANIAKGAAVNLIWRYADFIKLSESMRRQLKVAARKTGLNLLVTTSSLK 2595
Query 2726 QVVNVITTKISLKGG--KIVSTCFKLMLKATLLCVLAA---LVCYIVMPVHTLSIHDGYT 2780
V + T + GG +IVS L+ LL VL YI+ P+
Sbjct 2596 ADVPCMVTPFKIIGGHRRIVSWRRVLIHVFMLLVVLNPQWFTPWYIMRPIEY-------- 2647
Query 2781 NEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIG 2840
++ +K I + V RDI S D CFANK + F+ W+S R GSY N + CP+V +++ +G
Sbjct 2648 -NVVDFKVIDNAVIRDITSADQCFANKFSAFENWYSNRYGSYVNSRGCPMVVGVVSDIVG 2706
Query 2841 FIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFK 2900
+VPGLP LR + L + AVG++CYTP I Y F TSACVLAA CT+F
Sbjct 2707 SLVPGLPARFLR-VGTTLLPLVNYGLGAVGSVCYTPHYAINYDVFDTSACVLAATCTLFS 2765
Query 2901 DAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAE 2959
A G+ +PYC D L++ + Y L+P Y + S I+FP + V +V T E
Sbjct 2766 SASGERMPYCADAALIQNASRYDMLKPHVMYPFYEHSGYIRFPEV-ISAGVHIVRTMAME 2824
Query 2960 YCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALD 3019
YC+ G C+ SE G+C+S RWV+NN ++R SGV+CG A +L N+ P+ PVGA+D
Sbjct 2825 YCKVGRCDVSEAGLCMSLQPRWVVNNAYFRQQSGVYCGTSAFDLFMNMLLPIFTPVGAVD 2884
Query 3020 VSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLP 3079
++ S++ G ++A++V+ + YY ++FRR FG+Y+ V+ N L F+++ +LCL Y LP
Sbjct 2885 ITTSILMGALLAVVVSMSLYYLLRFRRAFGDYSGVIFTNILAFVLNVIVLCLEGPYPMLP 2944
Query 3080 GVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLR 3139
+Y++ +LY T YF +D++ + H+ + MF+ +VP W+T +Y+ + +H WF + +
Sbjct 2945 SIYAMVFLYATCYFGSDIACMMHVSFLIMFAGVVPLWVTVLYIVVVLSRHILWFASLCTK 3004
Query 3140 KRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALD 3199
+ V + F +F++AAL TF+L+KE++L+L+ E + Y +YLA+YNKYKY+SG +D
Sbjct 3005 RTVQVGDLAFHSFQDAALQTFMLDKEVFLRLKRE--ISSDAYFKYLAMYNKYKYYSGPMD 3062
Query 3200 TTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQ 3259
T +YREAAC HL AL +SN G D +YQPP+ S+ SA LQ+G +MA PSG VE C+V+
Sbjct 3063 TAAYREAACSHLVMALEKYSNGGGDTIYQPPRCSVASAALQAGLTRMAHPSGLVEPCLVK 3122
Query 3260 VTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIG 3319
V G+ TLNG+WLD+ V CPRHV+C+ +++ NP+Y L +R +N+ F V +RVIG
Sbjct 3123 VNYGSMTLNGIWLDNFVICPRHVMCSRDELANPDYPRLSMRAANYDFHVSQNGHNIRVIG 3182
Query 3320 HSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGS 3379
H+M+ LL+L VD +NPKTP Y F+R+ GQ S+LACY+G P+GVY C +R N T++ S
Sbjct 3183 HTMEGSLLKLTVDVNNPKTPAYSFIRVSTGQAMSLLACYDGLPTGVYTCTLRSNGTMRAS 3242
Query 3380 FLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTT 3439
FL GSCGS GF ++ V FCY+H +ELP G H GTD G FYGPF D+Q Q A D T
Sbjct 3243 FLCGSCGSPGFVMNGKEVQFCYLHQLELPNGTHTGTDFSGVFYGPFEDKQVPQLAAPDCT 3302
Query 3440 ITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGI 3499
IT+NVLAWLYAAV++G+ WFL + + + +FN A+KY + +T + + +L PL+A+TGI
Sbjct 3303 ITVNVLAWLYAAVLSGENWFLTKSSISPAEFNNCAVKYMCQSVTSESLQVLQPLAAKTGI 3362
Query 3500 AVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW 3559
+V M +ALK LL G GRTI+GS LEDE TP+D+ RQ GV QGKF+ + + T W
Sbjct 3363 SVERMLSALKVLLSAGFCGRTIMGSCSLEDEHTPYDIGRQMLGVKLQGKFQSMFRWTLQW 3422
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAM------LLVKHKHAFL 3613
+ F+ ++LIL+Q QW+ LPFTL + I A+ LL+KHKH +L
Sbjct 3423 FAIIFVLTILILLQLAQWTFV------GALPFTLLLPLIGFVAVCVGFVSLLIKHKHTYL 3476
Query 3614 CLFLLPSLATVAYFNMVYMP---ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLI 3670
++LLP AY+N Y P +++ + ++ + G L ++ + A LL
Sbjct 3477 TVYLLPVAMVTAYYNFQYTPEGVQGYLLSLYNYVNPGRIDVIGTDLLTMLIISVACTLL- 3535
Query 3671 LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMF 3730
+ R V DA R+W + + +Y + G+A AIS ++SV +NY+GV ++
Sbjct 3536 --SVRMVRTDAYSRIWYVCTAVGWLYNCWTGSADTVAISYLTFMVSVFTNYTGVACASLY 3593
Query 3731 LARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
A+ +V+V P + + +C+++ Y +GY C CYFG+F L+NR FR TLG Y+Y
Sbjct 3594 AAQFMVWVLKFLDPTILLLYGRFRCVLVCYLLVGYLCTCYFGVFNLINRLFRCTLGNYEY 3653
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
+VS+QE RYMNS GLLPP +S A LNIKL GIGG P +V+T+QS M+D+KCTSVVLL
Sbjct 3654 VVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIGGIPIYRVSTIQSNMTDLKCTSVVLL 3713
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
SVLQQLRVESSSKLWA CV+LHN+IL + TEAFE VSLLSVLLS+ GA++++ LC
Sbjct 3714 SVLQQLRVESSSKLWALCVKLHNEILASNSPTEAFEAFVSLLSVLLSLPGAINLDELCSS 3773
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDR 3970
+L+N + LQA+ASEFS+L SY Y AQ+AY+ AVA G + LKK++NVAKS D+
Sbjct 3774 ILENNSVLQAVASEFSNLSSYVDYENAQKAYDTAVATGAPASTVNALKKAMNVAKSVLDK 3833
Query 3971 DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNAR 4030
D A RKLE+M++ AMT MYKQAR+ED+R+KVT+AMQTMLF M+R+LD+DAL+NI+NNAR
Sbjct 3834 DVATTRKLERMSELAMTAMYKQARAEDRRSKVTAAMQTMLFNMIRRLDSDALSNILNNAR 3893
Query 4031 DGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSE 4090
+G VPL +IP T A KL++VVPD+ Y T T TYA + W++ QV DAD K V ++
Sbjct 3894 NGVVPLGVIPRTAANKLLLVVPDFSVYTATITMPTLTYAGSAWDVMQVADADGKTVNATD 3953
Query 4091 INMDNSPNLAWPLIVTALR--ANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAY 4148
I +NS NLAWPL+VTA R A S VKLQNNEL P +++M+ AG +QTAC D A+AY
Sbjct 3954 ITRENSVNLAWPLVVTAQRQQATSPVKLQNNELMPQTVKRMNVVAGVSQTACVTD-AVAY 4012
Query 4149 YNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFI 4208
YN +K GR V+A+L+D L +A+ KS G G + ELEPPC+F+ DTPKGP +KYLYF
Sbjct 4013 YNATKEGRHVMAILADTDGLAFAKVEKSTGDGFVILELEPPCKFMVDTPKGPALKYLYFT 4072
Query 4209 KGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPI 4268
KGL NL RG VLG+LA TVRL AG+ATEV +NS++LS C+F+VDP YKDYL +GG PI
Sbjct 4073 KGLKNLCRGTVLGTLACTVRLHAGSATEVASNSSILSLCSFSVDPEATYKDYLDNGGSPI 4132
Query 4269 TNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQ 4328
NCVKML HTGTG AIT P+AN+DQESFGGASCCLYCRCHI+HP G C KGK+VQ
Sbjct 4133 GNCVKMLTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHPGASGVCKYKGKFVQ 4192
Query 4329 IPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
IP NDP+GF +RN VC VC MW+GYGC C LRE +Q+ D FLN
Sbjct 4193 IPLVGVNDPIGFCIRNVVCAVCNMWQGYGCPCSSLREINLQARD-ECFLN 4241
Score = 289 bits (740), Expect = 3e-76, Method: Compositional matrix adjust.
Identities = 326/1183 (28%), Positives = 514/1183 (43%), Gaps = 143/1183 (12%)
Query 28 VRGFGDSVEEALSEAREHLKNGTCGLVELEKGV--LPQLEQPYVFIKRSDALSTNHG-HK 84
V G+ +EEAL A++ L+ LV + + P + V I S +TN G
Sbjct 29 VTGWDIPIEEALEYAKQQLRTPEPQLVFVPYYLSHAPGISGDRVVITDSIWYATNFGWQP 88
Query 85 VVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYR-NVLLRKNGNKGAGGHSYGIDLKSY 143
+ EL + DG++YGR G T GVL+P + I ++ +RK G G +S L +
Sbjct 89 IRELAMDKDGVRYGRGG-THGVLLPMQDPSFIMGDIDIQIRK---YGIGANSPPDVLPLW 144
Query 144 DLGDELGTD--PIEDYEQNW---NTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPL 198
D + G D P D+ N K G L+ + DNN G +
Sbjct 145 DGFSDPGPDVGPYLDFPDNCCPTKPKAKRGGDVYLSDQYG-------FDNN-----GILV 192
Query 199 DCIKDFLARAGKSMCTLSEQLDYIESKR--GVYCCRDHEHEIAWFTERSDKSYEHQTPFE 256
+ + L KS TL + L + R Y D ++A R Q+ F
Sbjct 193 EPVMKLLGVI-KSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFT 251
Query 257 IKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGR-IRSVYPVASPQECNNM 315
+ + P + +P ++ V K G +G+ + +V + S NN
Sbjct 252 VVGVTE-----QLVPGYYYPFSTSSVVEH---TKPTRGGPVGKTVEAV--MLSLYGTNNY 301
Query 316 HLST---LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPA 372
+ +T +KC++CD W + CG E + ++C + V+K C
Sbjct 302 NPATPVARLKCSYCDYYGWTPLKDIGTVNCLCGAE---FQLTSSCVDAESAGVIKPGCVM 358
Query 373 CQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC-FGGCVFAYVGCYNKRAYWVPRASADI 431
D G RL G RT FGG +++ +G N WVPRA + +
Sbjct 359 LLDKSPG---------------MRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIV 403
Query 432 GSGHTGITGD-NVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA-FID 489
H+G G + +N++L+E L I + D N A +A+ T A +
Sbjct 404 AGEHSGAVGSGDTVAINKELVEYLIE---GIRVDADTLDNPTCATFIANLDCDTKAPVVH 460
Query 490 TIKSLDYKSFKTIVESCGNYKVTKG-KPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIF 548
T++SL C K+ G KP+ + + L + Q A ++
Sbjct 461 TVESLQ--------GLCLANKIMLGDKPLP----TDEFHPFIVGL-AYHVQRACWYGALA 507
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-VTGGLVQ 607
+RT +A D R + ++ VY + + AY V +
Sbjct 508 SRTFEAFR----DFVRTEEERFAQFFGKVCAPINGCVYLAYTTGRVTLFSAYQVLNTAIA 563
Query 608 QTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAW----EILKFLITGVFDIVKGQ 663
++ + V+ L+PI EW+ K+S K AW E L L F +VKG+
Sbjct 564 KSKDAFGGVAAIVVDMLKPILEWVLKKMSIA----KGAWLPYAEGLLALFKAQFTVVKGK 619
Query 664 IQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRG 723
Q ++ D++ + + V AG K+ +L G + KG+ +
Sbjct 620 FQFLRASLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALYTGTYYYFSRKGVLTEVQLC 679
Query 724 KEQLQLLM-PLKAPKEVTFLEGDSHDTV-LTSEEVVLKNGELEALETPVDSFTNGAIVGT 781
++L LL+ P + EV L+GD V LT E+ G LE + D + GT
Sbjct 680 AKRLGLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGVLEEVFGASDV---KLVKGT 736
Query 782 PVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVR 841
V + + + +D Y + G + FRL+GG + VTFG++ V + V
Sbjct 737 LVSLASKLFVRTEDGFLYRYVKSGGV-LGKAFRLRGGG-VSKVTFGDEEVHTIPNTVTVN 794
Query 842 ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTN-----MGI 896
++++ E +D +L++ + + VE GT++ + ACVV +AV + L SDL ++ I
Sbjct 795 FSYDVCEGLDAILDKVMAPFQVEEGTKLEDLACVVQKAVYERL---SDLFSDCPAELRPI 851
Query 897 DLDEWSVATFYLFDDAGEENFSSRMYCSF---YPPDEEEEDDAECEEEEIDETCEHEYGT 953
+L+++ + +++ E+ MY S P D+E DD I++T E +
Sbjct 852 NLEDFLTSECFVYSKDYEKILMPEMYFSLEDAVPVDDEMVDD-------IEDTVEQASDS 904
Query 954 EDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLT 1013
+D + G +E ED D+T + ++ TP GY K+
Sbjct 905 DDQWLG---------------DEGAED-CDNTIQDVDVATS-MTTP-------CGYTKIA 940
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
++V IKC DIV+EA++ + V+VNAAN++L HGGGVAGALN+ATN AMQKES +YIK NG
Sbjct 941 EHVYIKCADIVQEARNYSYAVLVNAANVNLHHGGGVAGALNRATNNAMQKESSEYIKANG 1000
Query 1074 PLTVGGSCLLSGHNLAKK-CLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIF 1132
L GG LLS H LA LHVVGP+ G+D+ LL A Y + D +L PL+SAGIF
Sbjct 1001 SLQPGGHVLLSSHGLASHGILHVVGPDKRLGQDLALLDAVYAAYTGFDSVLTPLVSAGIF 1060
Query 1133 GAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR 1175
G +SL V+ V Y+ V D+ LYE+ + D P+
Sbjct 1061 GFTVEESLCSLVKNVACTTYVVVYDRQLYERALATSFDVPGPQ 1103
>sp|P0C6W5|R1AB_BCHK9 Replicase polyprotein 1ab OS=Bat coronavirus
HKU9 OX=694006 GN=rep PE=1 SV=1
Length=6930
Score = 2289 bits (5933), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1255/3110 (40%), Positives = 1833/3110 (59%), Gaps = 158/3110 (5%)
Query 1343 ILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDY-GVRFFFY 1401
++ VS + M+ +E L+P+ +D A + ++R +EG+ G F+ Y
Sbjct 1216 LVDVVSMSFSAMVNFGKEKGLLIPVVIDYPAFLKVLKR----FSPKEGLFSSNGYEFYGY 1271
Query 1402 TSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTT 1461
+ +P+ + LNSL PL+ +P G++ +G L +A MR L P V V S +V
Sbjct 1272 SRDKPLHEVSKDLNSLGRPLIMIPFGFIVNGQTLAVSAVSMRGLTVPHTVVVPSESSVPL 1331
Query 1462 YNGYLT---SSSKTSEEHFVETVSLAGSYRDWSYSGQRTELGVE------FLKRGDKIVY 1512
Y Y S T+ + FV + L G+ RDW +T V+ KRG+ Y
Sbjct 1332 YRAYFNGVFSGDTTAVQDFVVDILLNGA-RDWDV--LQTTCTVDRKVYKTICKRGN--TY 1386
Query 1513 HTLESPVEFHLDGEVL----SLDKLKSLLSLREVKT---IKVFTTVDNTNLHTQLVDMSM 1565
+ + + G+V+ ++ K ++ L + IKV TTVD N T LV +
Sbjct 1387 LCFDDTNLYAITGDVVLKFATVSKARAYLETKLCAPEPLIKVLTTVDGINYSTVLVSTAQ 1446
Query 1566 TYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF-EYYHTLDESFLGRYM 1624
+Y Q G + DG D + P EG + + + A EYY D + + R M
Sbjct 1447 SYRAQIGTVFCDGHDWSNKNPMPTDEGTHLYKQDNFSSAEVTAIREYYGVDDSNIIARAM 1506
Query 1625 SALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDA 1684
S + W + V G + D+NCYL+ + LQ ++V F+ P + AY + G+
Sbjct 1507 SIRKTVQTWPYTVVDGRVLLAQRDSNCYLNVAISLLQDIDVSFSTPWVCRAYDALKGGNP 1566
Query 1685 ANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEA 1744
+++A T G D ++ +L H + +A+RV+ VC+HCG TG +A
Sbjct 1567 LPMAEVLIALGKATPGVSDDAHMVLSAVLNHGTV-TARRVMQTVCEHCGVSQMVFTGTDA 1625
Query 1745 VMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQ-QGTFLCANE 1803
+ G++ D+L VS+ C CGR A +Y+ +Q+S +++MS P + L G + A
Sbjct 1626 CTFYGSVVLDDLYAPVSVVCQCGRPAIRYVSEQKSPWLLMSCTPTQVPLDTSGIWKTAIV 1685
Query 1804 YTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDG 1863
+ G GHY + + D + S+ K P TD+ Y TS+T+ K +Y LDG
Sbjct 1686 FRGPVTAGHYMYAVNGTLISVYDANTRRRTSDLKLPATDILYGPTSFTSDSKVETYYLDG 1745
Query 1864 VTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLT-CSNTKFADDLNQMT 1922
V T I+P Y K+ + Y+T PI++V P S+D F L+ C N + A+ N+
Sbjct 1746 VKRTTIDPDFSKYVKRGDYYFTTAPIEVV-AAPKLVTSYDGFYLSSCQNPQLAESFNKAI 1804
Query 1923 GFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKP 1982
TK +L +T +P++ GDVVAI + A G+ + KP+++ +P
Sbjct 1805 NATKTGPMKL-LTMYPNVAGDVVAISDDNVVAH-PYGSLHMGKPVLF---------VTRP 1853
Query 1983 NTWC-LRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENP-TIQKEVIE 2040
NTW L L ST V+T N+++VLAV+ P + E E P +++ +
Sbjct 1854 NTWKKLVPLLSTVVVNTPNTYDVLAVDPL------------PVNNETSEEPISVKAPIPL 1901
Query 2041 CDVKTTEVVGNVILKPSDEG-VKVTQELGHEDLMAAYVENTS-ITIKKPNELSLALGLKT 2098
+K T V+ P ++G + +E DL YVE + K + LS LGL+
Sbjct 1902 YGLKATMVLNGTTYVPGNKGHLLCLKEFTLTDLQTFYVEGVQPFVLLKASHLSKVLGLRV 1961
Query 2099 IATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTL-LFQLC 2157
+ +N + + AY A RL RV + + + T + +
Sbjct 1962 --SDSSLHVNHLSKGVVYAYA--------------ATRLTTRVTTSLLGGLVTRSVRKTA 2005
Query 2158 TFTKSTNS------------RIRASLPTTIAKNSVKSVAKL-CLDAG-------INYVKS 2197
F +STN ++ + K + V+ + + G +NY++S
Sbjct 2006 DFVRSTNPGSKCVGLLCLFYQLFMRFWLLVKKPPIVKVSGIIAYNTGCGVTTCVLNYLRS 2065
Query 2198 -------PKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELY--L 2248
+ KL +++ + CL IC GV LS APS + +
Sbjct 2066 RCGNISWSRLLKLLRYMLYIWFVWTCL--TIC-----GVWLSEPYAPSLVTRFKYFLGIV 2118
Query 2249 NSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAY 2308
+ ++ + +C++G+DSLD YPAL Q S + T + + E AY
Sbjct 2119 MPCDYVLVNETGTGWLHHLCMAGMDSLD-YPALRMQQHRYGS-PYNYTYILMLLEAFFAY 2176
Query 2309 MLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFY 2368
+L+T ++G+ A++ + Y + NSWL+ F+ I+++ P ++M+RMYI A +
Sbjct 2177 LLYTPALPIVGILAVLHLIVLYLPIP-LGNSWLVVFLYYIIRLVPFTSMLRMYIVIAFLW 2235
Query 2369 YIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWN 2428
+K ++H+ GC + C+MCYK+N A R+EC+T+VNG+KR FYV ANGG FC HNWN
Sbjct 2236 LCYKGFLHVRYGCNNVACLMCYKKNVAKRIECSTVVNGVKRMFYVNANGGTHFCTKHNWN 2295
Query 2429 CLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQK 2488
C++CDT+ STFI +VA DLS QFKRPI TD++ Y V SV V+NG ++ YF+ GQ+
Sbjct 2296 CVSCDTYTVDSTFICRQVALDLSAQFKRPIIHTDEAYYEVTSVEVRNGYVYCYFESDGQR 2355
Query 2489 TYERHPLSHFVNLDNLRANNTKGSLP-INVIVFDGKSKCDESASKSASVYYSQLMCQPIL 2547
+YER P+ F N+ L + KG+ P NV+VFD ++ +E+A K+A++YY+QL C+PIL
Sbjct 2356 SYERFPMDAFTNVSKLHYSELKGAAPAFNVLVFDATNRIEENAVKTAAIYYAQLACKPIL 2415
Query 2548 LLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVL 2607
L+D+ +V VGD ++ MF+AY + +S+ M+K+K L +TA +++ G+ ++ VL
Sbjct 2416 LVDKRMVGVVGDDATIARAMFEAYAQNYLLKYSIAMDKVKHLYSTALQQISSGMTVESVL 2475
Query 2608 STFVSAARQGVVD--TDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDL 2665
FV + R D +DVDT D++ C++L H E T DS NN + TY K + ++ ++
Sbjct 2476 KVFVGSTRAEAKDLESDVDTNDLVSCIRLCHQEGWEWTTDSWNNLVPTYIKQDTLSTLEV 2535
Query 2666 GACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTR 2725
G + NA+++NA +AK V+LIW D++ LSE +R+Q++ AA+K + +T ++ +
Sbjct 2536 GQFMTANAKYVNANIAKGAAVNLIWRYADFIKLSESMRRQLKVAARKTGLNLLVTTSSLK 2595
Query 2726 QVVNVITTKISLKGG--KIVSTCFKLMLKATLLCVLAA---LVCYIVMPVHTLSIHDGYT 2780
V + T + GG +IVS L+ LL VL YI+ P+
Sbjct 2596 ADVPCMVTPFKIIGGHRRIVSWRRVLIHVFMLLVVLNPQWFTPWYIMRPIEY-------- 2647
Query 2781 NEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIG 2840
++ +K I + V RDI S D CFANK + F+ W+S R GSY N + CP+V +++ +G
Sbjct 2648 -NVVDFKVIDNAVIRDITSADQCFANKFSAFENWYSNRYGSYVNSRGCPMVVGVVSDIVG 2706
Query 2841 FIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFK 2900
+VPGLP LR + L + AVG++CYTP I Y F TSACVLAA CT+F
Sbjct 2707 SLVPGLPARFLR-VGTTLLPLVNYGLGAVGSVCYTPHYAINYDVFDTSACVLAATCTLFS 2765
Query 2901 DAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAE 2959
A G+ +PYC D L++ + Y L+P Y + S I+FP + V +V T E
Sbjct 2766 SASGERMPYCADAALIQNASRYDMLKPHVMYPFYEHSGYIRFPEV-ISAGVHIVRTMAME 2824
Query 2960 YCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALD 3019
YC+ G C+ SE G+C+S RWV+NN ++R SGV+CG A +L N+ P+ PVGA+D
Sbjct 2825 YCKVGRCDVSEAGLCMSLQPRWVVNNAYFRQQSGVYCGTSAFDLFMNMLLPIFTPVGAVD 2884
Query 3020 VSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLP 3079
++ S++ G ++A++V+ + YY ++FRR FG+Y+ V+ N L F+++ +LCL Y LP
Sbjct 2885 ITTSILMGALLAVVVSMSLYYLLRFRRAFGDYSGVIFTNILAFVLNVIVLCLEGPYPMLP 2944
Query 3080 GVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLR 3139
+Y++ +LY T YF +D++ + H+ + MF+ +VP W+T +Y+ + +H WF + +
Sbjct 2945 SIYAMVFLYATCYFGSDIACMMHVSFLIMFAGVVPLWVTVLYIVVVLSRHILWFASLCTK 3004
Query 3140 KRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALD 3199
+ V + F +F++AAL TF+L+KE++L+L+ E + Y +YLA+YNKYKY+SG +D
Sbjct 3005 RTVQVGDLAFHSFQDAALQTFMLDKEVFLRLKRE--ISSDAYFKYLAMYNKYKYYSGPMD 3062
Query 3200 TTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQ 3259
T +YREAAC HL AL +SN G D +YQPP+ S+ SA LQ+G +MA PSG VE C+V+
Sbjct 3063 TAAYREAACSHLVMALEKYSNGGGDTIYQPPRCSVASAALQAGLTRMAHPSGLVEPCLVK 3122
Query 3260 VTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIG 3319
V G+ TLNG+WLD+ V CPRHV+C+ +++ NP+Y L +R +N+ F V +RVIG
Sbjct 3123 VNYGSMTLNGIWLDNFVICPRHVMCSRDELANPDYPRLSMRAANYDFHVSQNGHNIRVIG 3182
Query 3320 HSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGS 3379
H+M+ LL+L VD +NPKTP Y F+R+ GQ S+LACY+G P+GVY C +R N T++ S
Sbjct 3183 HTMEGSLLKLTVDVNNPKTPAYSFIRVSTGQAMSLLACYDGLPTGVYTCTLRSNGTMRAS 3242
Query 3380 FLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTT 3439
FL GSCGS GF ++ V FCY+H +ELP G H GTD G FYGPF D+Q Q A D T
Sbjct 3243 FLCGSCGSPGFVMNGKEVQFCYLHQLELPNGTHTGTDFSGVFYGPFEDKQVPQLAAPDCT 3302
Query 3440 ITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGI 3499
IT+NVLAWLYAAV++G+ WFL + + + +FN A+KY + +T + + +L PL+A+TGI
Sbjct 3303 ITVNVLAWLYAAVLSGENWFLTKSSISPAEFNNCAVKYMCQSVTSESLQVLQPLAAKTGI 3362
Query 3500 AVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW 3559
+V M +ALK LL G GRTI+GS LEDE TP+D+ RQ GV QGKF+ + + T W
Sbjct 3363 SVERMLSALKVLLSAGFCGRTIMGSCSLEDEHTPYDIGRQMLGVKLQGKFQSMFRWTLQW 3422
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAM------LLVKHKHAFL 3613
+ F+ ++LIL+Q QW+ LPFTL + I A+ LL+KHKH +L
Sbjct 3423 FAIIFVLTILILLQLAQWTFV------GALPFTLLLPLIGFVAVCVGFVSLLIKHKHTYL 3476
Query 3614 CLFLLPSLATVAYFNMVYMP---ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLI 3670
++LLP AY+N Y P +++ + ++ + G L ++ + A LL
Sbjct 3477 TVYLLPVAMVTAYYNFQYTPEGVQGYLLSLYNYVNPGRIDVIGTDLLTMLIISVACTLL- 3535
Query 3671 LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMF 3730
+ R V DA R+W + + +Y + G+A AIS ++SV +NY+GV ++
Sbjct 3536 --SVRMVRTDAYSRIWYVCTAVGWLYNCWTGSADTVAISYLTFMVSVFTNYTGVACASLY 3593
Query 3731 LARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
A+ +V+V P + + +C+++ Y +GY C CYFG+F L+NR FR TLG Y+Y
Sbjct 3594 AAQFMVWVLKFLDPTILLLYGRFRCVLVCYLLVGYLCTCYFGVFNLINRLFRCTLGNYEY 3653
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
+VS+QE RYMNS GLLPP +S A LNIKL GIGG P +V+T+QS M+D+KCTSVVLL
Sbjct 3654 VVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIGGIPIYRVSTIQSNMTDLKCTSVVLL 3713
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
SVLQQLRVESSSKLWA CV+LHN+IL + TEAFE VSLLSVLLS+ GA++++ LC
Sbjct 3714 SVLQQLRVESSSKLWALCVKLHNEILASNSPTEAFEAFVSLLSVLLSLPGAINLDELCSS 3773
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDR 3970
+L+N + LQA+ASEFS+L SY Y AQ+AY+ AVA G + LKK++NVAKS D+
Sbjct 3774 ILENNSVLQAVASEFSNLSSYVDYENAQKAYDTAVATGAPASTVNALKKAMNVAKSVLDK 3833
Query 3971 DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNAR 4030
D A RKLE+M++ AMT MYKQAR+ED+R+KVT+AMQTMLF M+R+LD+DAL+NI+NNAR
Sbjct 3834 DVATTRKLERMSELAMTAMYKQARAEDRRSKVTAAMQTMLFNMIRRLDSDALSNILNNAR 3893
Query 4031 DGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSE 4090
+G VPL +IP T A KL++VVPD+ Y T T TYA + W++ QV DAD K V ++
Sbjct 3894 NGVVPLGVIPRTAANKLLLVVPDFSVYTATITMPTLTYAGSAWDVMQVADADGKTVNATD 3953
Query 4091 INMDNSPNLAWPLIVTALR--ANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAY 4148
I +NS NLAWPL+VTA R A S VKLQNNEL P +++M+ AG +QTAC D A+AY
Sbjct 3954 ITRENSVNLAWPLVVTAQRQQATSPVKLQNNELMPQTVKRMNVVAGVSQTACVTD-AVAY 4012
Query 4149 YNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFI 4208
YN +K GR V+A+L+D L +A+ KS G G + ELEPPC+F+ DTPKGP +KYLYF
Sbjct 4013 YNATKEGRHVMAILADTDGLAFAKVEKSTGDGFVILELEPPCKFMVDTPKGPALKYLYFT 4072
Query 4209 KGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPI 4268
KGL NL RG VLG+LA TVRL AG+ATEV +NS++LS C+F+VDP YKDYL +GG PI
Sbjct 4073 KGLKNLCRGTVLGTLACTVRLHAGSATEVASNSSILSLCSFSVDPEATYKDYLDNGGSPI 4132
Query 4269 TNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQ 4328
NCVKML HTGTG AIT P+AN+DQESFGGASCCLYCRCHI+HP G C KGK+VQ
Sbjct 4133 GNCVKMLTPHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHPGASGVCKYKGKFVQ 4192
Query 4329 IPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
IP NDP+GF +RN VC VC MW+GYGC C LRE +Q+ D FLN
Sbjct 4193 IPLVGVNDPIGFCIRNVVCAVCNMWQGYGCPCSSLREINLQARD-ECFLN 4241
Score = 288 bits (738), Expect = 5e-76, Method: Compositional matrix adjust.
Identities = 326/1183 (28%), Positives = 514/1183 (43%), Gaps = 143/1183 (12%)
Query 28 VRGFGDSVEEALSEAREHLKNGTCGLVELEKGV--LPQLEQPYVFIKRSDALSTNHG-HK 84
V G+ +EEAL A++ L+ LV + + P + V I S +TN G
Sbjct 29 VTGWDIPIEEALEYAKQQLRTPEPQLVFVPYYLSHAPGISGDRVVITDSIWYATNFGWQP 88
Query 85 VVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYR-NVLLRKNGNKGAGGHSYGIDLKSY 143
+ EL + DG++YGR G T GVL+P + I ++ +RK G G +S L +
Sbjct 89 IRELAMDKDGVRYGRGG-THGVLLPMQDPSFIMGDIDIQIRK---YGIGANSPPDVLPLW 144
Query 144 DLGDELGTD--PIEDYEQNW---NTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPL 198
D + G D P D+ N K G L+ + DNN G +
Sbjct 145 DGFSDPGPDVGPYLDFPDNCCPTKPKAKRGGDVYLSDQYG-------FDNN-----GILV 192
Query 199 DCIKDFLARAGKSMCTLSEQLDYIESKR--GVYCCRDHEHEIAWFTERSDKSYEHQTPFE 256
+ + L KS TL + L + R Y D ++A R Q+ F
Sbjct 193 EPVMKLLGVI-KSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFT 251
Query 257 IKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGR-IRSVYPVASPQECNNM 315
+ + P + +P ++ V K G +G+ + +V + S NN
Sbjct 252 VVGVTE-----QLVPGYYYPFSTSSVVEH---TKPTRGGPVGKTVEAV--MLSLYGTNNY 301
Query 316 HLST---LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPA 372
+ +T +KC++CD W + CG E + ++C + V+K C
Sbjct 302 NPATPVARLKCSYCDYYGWTPLKDIGTVNCLCGAE---FQLTSSCVDAESAGVIKPGCVM 358
Query 373 CQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC-FGGCVFAYVGCYNKRAYWVPRASADI 431
D G RL G RT FGG +++ +G N WVPRA + +
Sbjct 359 LLDKSPG---------------MRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIV 403
Query 432 GSGHTGITGD-NVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA-FID 489
H+G G + +N++L+E L I + D N A +A+ T A +
Sbjct 404 AGEHSGAVGSGDTVAINKELVEYLIE---GIRVDADTLDNPTCATFIANLDCDTKAPVVH 460
Query 490 TIKSLDYKSFKTIVESCGNYKVTKG-KPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIF 548
T++SL C K+ G KP+ + + L + Q A ++
Sbjct 461 TVESLQ--------GLCLANKIMLGDKPLP----TDEFHPFIVGL-AYHVQRACWYGALA 507
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-VTGGLVQ 607
+RT +A D R + ++ VY + + AY V +
Sbjct 508 SRTFEA----FRDFVRTEEERFAQFFGKVCAPINGCVYLAYTTGRVTLFSAYQVLNTAIA 563
Query 608 QTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAW----EILKFLITGVFDIVKGQ 663
++ + V+ L+PI EW+ K+S K AW E L L F +VKG+
Sbjct 564 KSKDAFGGVAAIVVDMLKPILEWVLKKMSIA----KGAWLPYAEGLLALFKAQFTVVKGK 619
Query 664 IQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRG 723
Q ++ D++ + + V AG K+ +L G + KG+ +
Sbjct 620 FQFLRASLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALYTGTYYYFSRKGVLTEVQLC 679
Query 724 KEQLQLLM-PLKAPKEVTFLEGDSHDTV-LTSEEVVLKNGELEALETPVDSFTNGAIVGT 781
++L LL+ P + EV L+GD V LT E+ G LE + D + GT
Sbjct 680 AKRLGLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGVLEEVFGASDV---KLVKGT 736
Query 782 PVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVR 841
V + + + +D Y + G + FRL+GG + VTFG++ V + V
Sbjct 737 LVSLASKLFVRTEDGFLYRYVKSGGV-LGKAFRLRGGG-VSKVTFGDEEVHTIPNTVTVN 794
Query 842 ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTN-----MGI 896
++++ E +D +L++ + + VE GT++ + ACVV +AV + L SDL ++ I
Sbjct 795 FSYDVCEGLDAILDKVMAPFQVEEGTKLEDLACVVQKAVYERL---SDLFSDCPAELRPI 851
Query 897 DLDEWSVATFYLFDDAGEENFSSRMYCSF---YPPDEEEEDDAECEEEEIDETCEHEYGT 953
+L+++ + +++ E+ MY S P D+E DD I++T E +
Sbjct 852 NLEDFLTSECFVYSKDYEKILMPEMYFSLEDAVPVDDEMVDD-------IEDTVEQASDS 904
Query 954 EDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLT 1013
+D + G +E ED D+T + ++ TP GY K+
Sbjct 905 DDQWLG---------------DEGAED-CDNTIQDVDVATS-MTTP-------CGYTKIA 940
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
++V IKC DIV+EA++ + V+VNAAN++L HGGGVAGALN+ATN AMQKES +YIK NG
Sbjct 941 EHVYIKCADIVQEARNYSYAVLVNAANVNLHHGGGVAGALNRATNNAMQKESSEYIKANG 1000
Query 1074 PLTVGGSCLLSGHNLAKK-CLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIF 1132
L GG LLS H LA LHVVGP+ G+D+ LL A Y + D +L PL+SAGIF
Sbjct 1001 SLQPGGHVLLSSHGLASHGILHVVGPDKRLGQDLALLDAVYAAYTGFDSVLTPLVSAGIF 1060
Query 1133 GAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR 1175
G +SL V+ V Y+ V D+ LYE+ + D P+
Sbjct 1061 GFTVEESLCSLVKNVACTTYVVVYDRQLYERALATSFDVPGPQ 1103
>sp|K9N638|R1A_MERS1 Replicase polyprotein 1a OS=Middle East respiratory
syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
OX=1263720 GN=1a PE=1 SV=1
Length=4391
Score = 2189 bits (5671), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1241/3286 (38%), Positives = 1868/3286 (57%), Gaps = 198/3286 (6%)
Query 1235 INGKLYHDSQNMLRGEDMSFLEKDAPYMVGD-VITSG-----DITCVVIPSKKAGGTTEM 1288
I G + S+ ++ E ++ P VGD V+ G +I VV P +A +
Sbjct 1156 IAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSL 1215
Query 1289 LSR---ALKKVPVDEYITTYPGQGCAG--------YTLEEAKTALKKCKSAFYVLPSEAP 1337
LS+ A+ P+ +T G G Y + EAKT + ++ V S
Sbjct 1216 LSKCYKAMNAYPL--VVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTI 1273
Query 1338 NAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVR 1397
+ L LR + A++ + +C D A ++ K + VD GV+
Sbjct 1274 VDIPQSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNKGVDYTKKFLTVD-GVQ 1332
Query 1398 FFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPD 1457
++ YTSK+ + I+ + N + +++MP+GYV+HG +L +A +R + P V +++ +
Sbjct 1333 YYCYTSKDTLDDILQQANK-SVGIISMPLGYVSHGLDLIQAGSVVRRVNVPYVCLLANKE 1391
Query 1458 AVTTYNGYLTSSSK--TSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKI----- 1510
L S E F++ V G Y W EL V+ L+ +
Sbjct 1392 Q----EAILMSEDVKLNPSEDFIKHVRTNGGYNSWHLV--EGELLVQDLRLNKLLHWSDQ 1445
Query 1511 -------VYHTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIKVFTTVDNTNLHTQLV 1561
V++ +++ F + +L ++ L R + TI+V TVD N T ++
Sbjct 1446 TICYKDSVFYVVKNSTAFPFE----TLSACRAYLDSRTTQQLTIEVLVTVDGVNFRTVVL 1501
Query 1562 DMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV---LPSDDTLRSEAFEYYHTLDES 1618
+ TY Q G + +GAD++ P G + ++ L +D+T + E Y +D +
Sbjct 1502 NNKNTYRSQLGCVFFNGADISDTIPDEKQNGHSLYLADNLTADETKALK--ELYGPVDPT 1559
Query 1619 FLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL-EVKFNAPALQEAYY 1677
FL R+ S KWK + S+K +DNNCYL++V++ L L ++KF PALQ A+
Sbjct 1560 FLHRFYSLKAAVHKWKMVVCDKVRSLKLSDNNCYLNAVIMTLDLLKDIKFVIPALQHAFM 1619
Query 1678 RARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SAKRVLNVVCKHCGQKT 1736
+ + GD+ +F ALI+AY N T G D + +L A L SA+ V C CG K
Sbjct 1620 KHKGGDSTDFIALIMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKD 1679
Query 1737 TTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQG 1796
L G++A Y+G + ++L+ ++ C CG + + +V+ + ++++S P E +
Sbjct 1680 VVLQGLKACCYVGVQTVEDLRARMTYVCQCGGERHRQIVEHTTPWLLLSGTPNEKLVTTS 1739
Query 1797 T---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEYKGPVTDVFYKETSYT 1851
T F+ N + G GHY H K L + D ++K S++K VTDV + Y+
Sbjct 1740 TAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTSDWKCKVTDVLFPGQKYS 1799
Query 1852 TTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYT-EQPIDLVPTQPLPNASFDNFKLTCS 1910
+ V Y LDG TE++P L +Y KD Y+T E P+ P L + + N L S
Sbjct 1800 SDCNVVRYSLDGNFRTEVDPDLSAFYVKDGKYFTSEPPVTYSPATILAGSVYTNSCLVSS 1859
Query 1911 NTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLL 1963
+ + D N + GF +KP +++ + +F P +GDV+ ++ Y +K GA
Sbjct 1860 DGQPGGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPIYKNGAMYK 1919
Query 1964 HKPIVWHINQATTKTTF-KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQ 2022
KPI+W +N+A+ T K N LR ++ P++ N F L+VE T
Sbjct 1920 GKPILW-VNKASYDTNLNKFNRASLRQIFDVAPIELENKFTPLSVEST------------ 1966
Query 2023 PTSEEVVENPTIQKE--VIECD-VKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE- 2078
P V+ +Q+E +++C + V NV D G V + L EDL YV+
Sbjct 1967 PVEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVSFVADDSGTPVVEYLSKEDLHTLYVDP 2026
Query 2079 NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAI---------- 2128
+ + K N LS L L T+ + IN V S L L +A+
Sbjct 2027 KYQVIVLKDNVLSSMLRLHTVES---GDINVVAASGSLTRKVKLLFRASFYFKEFATRTF 2083
Query 2129 ----TTSNCAKRLAQRV---------FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTT- 2174
+C K + + + +++ +F L + +K + ++ S T
Sbjct 2084 TATTAVGSCIKSVVRHLGVTKGILTGCFSFVKMLFMLPLAYFSDSKLGTTEVKVSALKTA 2143
Query 2175 --IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLS 2232
+ N VK +D ++ ++ + + + L + L S+ + VL S
Sbjct 2144 GVVTGNVVKQCCTAAVDLSMDKLRRVDWKSTLRLLLMLCTTMVLLSSVYHLYVFNQVLSS 2203
Query 2233 N-------------------FGAPSYCNGVRELY-LNSSNVTTMDFCEG-SFPCSICLSG 2271
+ G S C+G+ Y NS +V T FC S C+ CL
Sbjct 2204 DVMFEDAQGLKKFYKEVRAYLGISSACDGLASAYRANSFDVPT--FCANRSAMCNWCLIS 2261
Query 2272 LDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGY- 2330
DS+ YPAL+ +Q +S Y L++ L A E LAYML+T F L L+ + FF
Sbjct 2262 QDSITHYPALKMVQTHLSHYVLNIDWLWFAFETGLAYMLYTSAFNWLLLAGTLHYFFAQT 2321
Query 2331 -----FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSST 2385
+ S+ + S W I P++ +VRMY A + + K Y H+++GC +
Sbjct 2322 SIFVDWRSYNYAVSSAFWLFTHI----PMAGLVRMYNLLACLWLLRKFYQHVINGCKDTA 2377
Query 2386 CMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDE 2445
C++CYKRNR TRVE +T+V G KR+FY+ ANGG FC+ HNWNC++CDT G+TFI +E
Sbjct 2378 CLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDTAGVGNTFICEE 2437
Query 2446 VARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLR 2505
VA DL+ +RPIN TD+S Y VDSV VK + + + GQ YER PL F NLD L+
Sbjct 2438 VANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPFYERFPLCAFTNLDKLK 2497
Query 2506 ----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDST 2561
T G N I++D + ES ++SA VYYSQ++C+ ILL+D +LV+ VGDS+
Sbjct 2498 FKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSS 2557
Query 2562 EVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VD 2620
E++ KMFD++V++F + ++V +KL+ L++TA + +G VL+TF+ AAR V+
Sbjct 2558 EIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAARGPAGVE 2617
Query 2621 TDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQV 2680
+DV+T ++++ ++ +H D+++T +S NN++ +Y K ++++ DLG+ IDCNA +N V
Sbjct 2618 SDVETNEIVDSVQYAHKHDIQITNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQIV 2677
Query 2681 AKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG 2740
++ N + IWN YM LS+ L++QIR A +K N+ FRLT + R N+++ + +
Sbjct 2678 LRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFT--AN 2735
Query 2741 KIVSTC-----------FKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAI 2789
KIV K + AT++ L A++ Y+ +P ++ + Y + I+ +K +
Sbjct 2736 KIVGGAPTWFNALRDFTLKGYVLATIIVFLCAVLMYLCLPTFSMVPVEFYEDRILDFKVL 2795
Query 2790 QDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKSCPVVAAIITREIGFIVPGLPG 2848
+G+ RD+ D CFANKH F W+ + GG Y N +CP+ A+I G +P +P
Sbjct 2796 DNGIIRDVNPDDKCFANKHRSFTQWYHEHVGGVYDNSITCPLTVAVIAGVAGARIPDVP- 2854
Query 2849 TVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVP 2908
T L +N + F+ RVF+ G++CYTP I Y F+ S C+L +ECT+F+DA G+ P
Sbjct 2855 TTLAWVNNQIIFFVSRVFANTGSVCYTPIDEIPYKSFSDSGCILPSECTMFRDAEGRMTP 2914
Query 2909 YCYDTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNTYLEGSVRVVTTFDAEYCRHGTCE 2967
YC+D +L G+ +YS++RP RY L DG++ I+FP E ++R+ T +YCR G+CE
Sbjct 2915 YCHDPTVLPGAFAYSQMRPHVRYDLYDGNMFIKFPEVVFESTLRITRTLSTQYCRFGSCE 2974
Query 2968 RSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAG 3027
++ G+C++T+G W + N+H+ GV+CG D ++++ + L QP+ ++ S+V G
Sbjct 2975 YAQEGVCITTNGSWAIFNDHHLNRPGVYCGSDFIDIVRRLAVSLFQPITYFQLTTSLVLG 3034
Query 3028 GIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYL 3087
+ +T YY K +R F +Y + +++ +C V + Y+ Y
Sbjct 3035 IGLCAFLTLLFYYINKVKRAFADYTQCAVIAVVAAVLNSLCICFVASIPLCIVPYTALYY 3094
Query 3088 YLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV--MFN 3145
Y TFYFTN+ +F+ H+ W+ MF PIVP W+T +Y + +H W + +K V +
Sbjct 3095 YATFYFTNEPAFIMHVSWYIMFGPIVPIWMTCVYTVAMCFRHFFWVLAYFSKKHVEVFTD 3154
Query 3146 GVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYRE 3205
G +F++AA F++NK+ Y LR+ L Y+R+L L+NKYKYFSGA++T +YRE
Sbjct 3155 GKLNCSFQDAASNIFVINKDTYAALRNS--LTNDAYSRFLGLFNKYKYFSGAMETAAYRE 3212
Query 3206 AACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTT 3265
AA CHLAKAL +S +G+D+LYQPP SITS VLQSG KM+ PSG VE CMVQVTCG+
Sbjct 3213 AAACHLAKALQTYSETGSDLLYQPPNCSITSGVLQSGLVKMSHPSGDVEACMVQVTCGSM 3272
Query 3266 TLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVIGHSM 3322
TLNGLWLD+TV+CPRHV+C A+ + +PNY+ LLI +NHSF VQ LRV+GH+M
Sbjct 3273 TLNGLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRVVGHAM 3332
Query 3323 QNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLN 3382
Q LL+L VD +NP TP Y F ++PG FSVLACYNG P+G + MRPN+TIKGSFL
Sbjct 3333 QGTLLKLTVDVANPSTPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLC 3392
Query 3383 GSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITL 3442
GSCGSVG+ + ++FCYMH MEL G H G+ +G YG F+D+Q Q TD ++
Sbjct 3393 GSCGSVGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCSV 3452
Query 3443 NVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY-EPLTQDHVDILGPLSAQTGIAV 3501
NV+AWLYAA++NG WF+ T++ FN A+ + E + VD+L + +TG+A+
Sbjct 3453 NVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDML---AVKTGVAI 3509
Query 3502 LDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWML 3561
+ A+++L G G+ ILGST+LEDEFTP DV Q GV Q +K+ GT HW+
Sbjct 3510 EQLLYAIQQLY-TGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQSGVRKVTYGTAHWLF 3568
Query 3562 LTFLTSLLILVQSTQWSLFFFVYEN---AFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
T +++ +I++Q+T+++L+ +++E P MA MLLVKHKH FL LFLL
Sbjct 3569 ATLVSTYVIILQATKFTLWNYLFETIPTQLFPLLFVTMAFV---MLLVKHKHTFLTLFLL 3625
Query 3619 PSLATVAYFNMVYMP----ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTA 3674
P + Y N+VY P +S ++ + WL + + D +Y S ++L+++
Sbjct 3626 PVAICLTYANIVYEPTTPISSALIAVANWLAPTNAYMRTTH-TDIGVYISMSLVLVIVVK 3684
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R + L + + +Y G A I+ V ++TS+Y+ V + LA+
Sbjct 3685 RLYNPSLSNFALALCSGVMWLYTYSIGEA-SSPIAYLVFVTTLTSDYTITVFVTVNLAKV 3743
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
+ Y P L + ++ I+L+Y LG+ C CYFG+F LLN R +GVYD+ VST
Sbjct 3744 CTYAIFAYSPQLTLVFPEVKMILLLYTCLGFMCTCYFGVFSLLNLKLRAPMGVYDFKVST 3803
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
QEFR+M + L P++S +A LN KL+GIGG PCIKVA +QSK++D+KCTSVVLLSVLQ
Sbjct 3804 QEFRFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQSKLTDLKCTSVVLLSVLQ 3863
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
QL +E++S+ WA CV+ HNDIL A D +EAFEK VSL + L++ G VD++ L ++ D
Sbjct 3864 QLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFDT 3923
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAA 3973
+ LQA SEFS L ++A AQ+AY++A+ +GD S VLK L+K++N+AK+ +++D A
Sbjct 3924 PSVLQATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDKA 3983
Query 3974 MQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGC 4033
+ RKLE+MADQAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN II+NAR+GC
Sbjct 3984 VARKLERMADQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGIISNARNGC 4043
Query 4034 VPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINM 4093
+PL++IPL + KL VV+PD+ + + YA ALW+I + + D++IV+ S++ +
Sbjct 4044 IPLSVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDV-V 4102
Query 4094 DNSPNLAWPLIVTALRAN-SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNS 4152
D++ NL WPL++ RA+ SAVKLQNNE+ P L+ M +AG QT C + ++LAYY
Sbjct 4103 DSNENLTWPLVLECTRASTSAVKLQNNEIKPSGLKTMVVSAGQEQTNC-NTSSLAYYEPV 4161
Query 4153 KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLN 4212
+G + ++ALLSD+ LKWAR DG ++ EL+PPC+F+ PKGP+++YLYF+K LN
Sbjct 4162 QGRKMLMALLSDNAYLKWARVEGKDGFVSV--ELQPPCKFLIAGPKGPEIRYLYFVKNLN 4219
Query 4213 NLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCV 4272
NL+RG VLG +AATVRLQAG+ TE +NS+VLS F VDP KAY D++ +GG P+TNCV
Sbjct 4220 NLHRGQVLGHIAATVRLQAGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCV 4279
Query 4273 KMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTT 4332
KML TGTG AI+V PE+ DQE++GGAS CLYCR HI+HP+ G C KGK+VQIP
Sbjct 4280 KMLTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPAQ 4339
Query 4333 CANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
C DPVGF L NT C VC W GYGC+CD LR+ + + S FLN
Sbjct 4340 CVRDPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQSKDSNFLN 4385
Score = 305 bits (781), Expect = 5e-81, Method: Compositional matrix adjust.
Identities = 314/1190 (26%), Positives = 519/1190 (44%), Gaps = 163/1190 (14%)
Query 101 GITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQN 160
G +G+ P+ E +N+LLRK G GG+ Y Y+ + + ++D+E +
Sbjct 123 GKPIGMFFPYDIELVTGKQNILLRKYGR---GGYHY--TPFHYERDNTSCPEWMDDFEAD 177
Query 161 WNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG-KSMCTLSEQL 219
K+ L++L GG VT VD CG DG P+ +A+ G + + +
Sbjct 178 PKGKYAQNLLKKLI----GGDVTP-VDQYMCGVDGKPISAYAFLMAKDGITKLADVEADV 232
Query 220 DYIESKRGVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNS 279
G +++ + + W ER D Y Q+ F I S + D + P + F L
Sbjct 233 AARADDEGFITLKNNLYRLVWHVERKDVPYPKQSIFTINSVVQKDGVENTPPHY-FTLGC 291
Query 280 KVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN---MHLSTLMKCNHCDEVSWQTCDF 336
K+ + PR + + + +Y + N ++ S ++C C SW T +
Sbjct 292 KILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLENPTYIYHSAFIECGSCGNDSWLTGNA 351
Query 337 LKATCEHCGTENLVIEGPT-TCGYLPTNAVVKMPCPACQDPEIGP--EHSVADYHNHSNI 393
++ CG + + G + NA++ CP + +HSVA ++ +
Sbjct 352 IQGFACGCGASYTANDVEVQSSGMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSE 411
Query 394 ETRLRKGGR--TRCFGGCVFAYVGCYNKRAYWVPRASADIG----SGHTGITG--DNVET 445
+ + T FGG +AY GC Y+VPRA + + S TG TG + V
Sbjct 412 RCNVIADSKSFTLIFGGVAYAYFGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQ 471
Query 446 LNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVES 505
+ LE + + ++N VG+F +N+ V IL+ + + +K + + +
Sbjct 472 IANMFLE---QTQHSLNFVGEFVVNDVVLAILSGTTTNVDKIRQLLKGVTLDKLRDYLAD 528
Query 506 CGNYKVTKGKPVKGAWNIG----QQRSVLTP---LCGFPSQAAGV------IRSIFARTL 552
+ VT G + A N+G Q ++ P L G V + + TL
Sbjct 529 Y-DVAVTAGPFMDNAINVGGTGLQYAAITAPYVVLTGLGESFKKVATIPYKVCNSVKDTL 587
Query 553 DAANHSIPDLQRAAVTILD-GISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQ 611
HS+ L R +D G+S S L D + DL SV ++ L +T
Sbjct 588 TYYAHSV--LYRVFPYDMDSGVSSFSELLFDCV----DL---SVASTYFLVRLLQDKTGD 638
Query 612 WLSNLLG---TTVEKL-RPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVA 667
++S ++ T V KL FE EA + FL D + + + + V
Sbjct 639 FMSTIITSCQTAVSKLLDTCFEATEATFN----FLLDLAGLFRIFLRNAYVYTSQGFVVV 694
Query 668 SDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLG--EVFIAQSKGLYRQCIRGK- 724
+ + VK +D++NK +++ +V+ AG+ + ++ E I S Y + K
Sbjct 695 NGKVSTLVKQVLDLLNKGMQLLHTKVSWAGSNISAVIYSGRESLIFPSGTYYCVTTKAKS 754
Query 725 --EQLQLLMPLK-APKEVTFLEGDSHDTVLTSE------EVVLKNGELEALETPVDSFTN 775
+ L +++P + + K++ L+ + T ++ E V+ E + +P
Sbjct 755 VQQDLDVILPGEFSKKQLGLLQPTDNSTTVSVTVSSNMVETVVGQLEQTNMHSP------ 808
Query 776 GAIVGTPVCVNGLMLLEIKDKEQYCALSPGLL---ATNNVFRLKGGAPIKGVTFGEDTVW 832
IVG V ++ + + K+++ + A P A +FRLKGGAP+K V FG D V
Sbjct 809 DVIVGDYVIISEKLFVRSKEEDGF-AFYPACTNGHAVPTLFRLKGGAPVKKVAFGGDQVH 867
Query 833 EVQGYKNVRITFELDERVDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL 891
EV ++V + + + +D +L + + V+ + EFA VV E V L LL
Sbjct 868 EVAAVRSVTVEYNIHAVLDTLLASSSLRTFVVDKSLSIEEFADVVKEQVSDLL---VKLL 924
Query 892 TNMGI---DLDEWSVATFYLFDDAGEENFSSRMYCSFYPP--DEE---------EEDDAE 937
M I DLD++ A Y F+ G+ ++SS M S +P DEE EE ++E
Sbjct 925 RGMPIPDFDLDDFIDAPCYCFNAEGDASWSSTMIFSLHPVECDEECSEVEASDLEEGESE 984
Query 938 CEEEEIDETCEHEYGTEDDY------QGLPLEFGASAETVRVEEEEE------------- 978
C E E + + DD + PL+ A T V+EE +
Sbjct 985 CISETSTEQVDVSHEISDDEWAAAVDEAFPLD-EAEDVTESVQEEAQPVEVPVEDIAQVV 1043
Query 979 -EDWLDDT---TEQSEIEPEPEPTPEEP-------------------------------- 1002
D L +T ++ E+ P+ P EP
Sbjct 1044 IADTLQETPVVSDTVEVPPQVVKLPSEPQTIQPEVKEVAPVYEADTEQTQSVTVKPKRLR 1103
Query 1003 ----VNQFTGYLK--LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKA 1056
V+ + + +T+ V I D ++ A+ V+VNAAN HLKHGGG+AGA+N A
Sbjct 1104 KKRNVDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAA 1163
Query 1057 TNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
+ GA+QKESD+YI GPL VG S LL GH+LAK LHVVGP+ A +D+ LL Y+
Sbjct 1164 SKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAM 1223
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVM 1166
N+ +++ PL+SAGIFG KP S ++ +T+V + VN + +Y+ + +
Sbjct 1224 NAYPLVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTI 1273
>sp|K9N7C7|R1AB_MERS1 Replicase polyprotein 1ab OS=Middle East
respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
OX=1263720 GN=rep PE=1 SV=1
Length=7078
Score = 2184 bits (5659), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1238/3282 (38%), Positives = 1870/3282 (57%), Gaps = 192/3282 (6%)
Query 1235 INGKLYHDSQNMLRGEDMSFLEKDAPYMVGD-VITSG-----DITCVVIPSKKAGGTTEM 1288
I G + S+ ++ E ++ P VGD V+ G +I VV P +A +
Sbjct 1156 IAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSL 1215
Query 1289 LSR---ALKKVPVDEYITTYPGQGCAG--------YTLEEAKTALKKCKSAFYVLPSEAP 1337
LS+ A+ P+ +T G G Y + EAKT + ++ V S
Sbjct 1216 LSKCYKAMNAYPL--VVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTI 1273
Query 1338 NAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVR 1397
+ L LR + A++ + +C D A ++ K + VD GV+
Sbjct 1274 VDIPQSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNKGVDYTKKFLTVD-GVQ 1332
Query 1398 FFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPD 1457
++ YTSK+ + I+ + N + +++MP+GYV+HG +L +A +R + P V +++ +
Sbjct 1333 YYCYTSKDTLDDILQQANK-SVGIISMPLGYVSHGLDLIQAGSVVRRVNVPYVCLLANKE 1391
Query 1458 AVTTYNGYLTSSSKTS-EEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKI------ 1510
++ K + E F++ V G Y W EL V+ L+ +
Sbjct 1392 QEAIL---MSEDVKLNPSEDFIKHVRTNGGYNSWHLV--EGELLVQDLRLNKLLHWSDQT 1446
Query 1511 ------VYHTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIKVFTTVDNTNLHTQLVD 1562
V++ +++ F + +L ++ L R + TI+V TVD N T +++
Sbjct 1447 ICYKDSVFYVVKNSTAFPFE----TLSACRAYLDSRTTQQLTIEVLVTVDGVNFRTVVLN 1502
Query 1563 MSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV---LPSDDTLRSEAFEYYHTLDESF 1619
TY Q G + +GAD++ P G + ++ L +D+T + E Y +D +F
Sbjct 1503 NKNTYRSQLGCVFFNGADISDTIPDEKQNGHSLYLADNLTADETKALK--ELYGPVDPTF 1560
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL-EVKFNAPALQEAYYR 1678
L R+ S KWK + S+K +DNNCYL++V++ L L ++KF PALQ A+ +
Sbjct 1561 LHRFYSLKAAVHKWKMVVCDKVRSLKLSDNNCYLNAVIMTLDLLKDIKFVIPALQHAFMK 1620
Query 1679 ARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SAKRVLNVVCKHCGQKTT 1737
+ GD+ +F ALI+AY N T G D + +L A L SA+ V C CG K
Sbjct 1621 HKGGDSTDFIALIMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDV 1680
Query 1738 TLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGT 1797
L G++A Y+G + ++L+ ++ C CG + + +V+ + ++++S P E + T
Sbjct 1681 VLQGLKACCYVGVQTVEDLRARMTYVCQCGGERHRQIVEHTTPWLLLSGTPNEKLVTTST 1740
Query 1798 ---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEYKGPVTDVFYKETSYTT 1852
F+ N + G GHY H K L + D ++K S++K VTDV + Y++
Sbjct 1741 APDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTSDWKCKVTDVLFPGQKYSS 1800
Query 1853 TIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYT-EQPIDLVPTQPLPNASFDNFKLTCSN 1911
V Y LDG TE++P L +Y KD Y+T E P+ P L + + N L S+
Sbjct 1801 DCNVVRYSLDGNFRTEVDPDLSAFYVKDGKYFTSEPPVTYSPATILAGSVYTNSCLVSSD 1860
Query 1912 TKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLH 1964
+ D N + GF +KP +++ + +F P +GDV+ ++ Y +K GA
Sbjct 1861 GQPGGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPIYKNGAMYKG 1920
Query 1965 KPIVWHINQATTKTTF-KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQP 2023
KPI+W +N+A+ T K N LR ++ P++ N F L+VE T P
Sbjct 1921 KPILW-VNKASYDTNLNKFNRASLRQIFDVAPIELENKFTPLSVEST------------P 1967
Query 2024 TSEEVVENPTIQKE--VIECD-VKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE-N 2079
V+ +Q+E +++C + V NV D G V + L EDL YV+
Sbjct 1968 VEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVSFVADDSGTPVVEYLSKEDLHTLYVDPK 2027
Query 2080 TSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAI----------- 2128
+ + K N LS L L T+ + IN V S L L +A+
Sbjct 2028 YQVIVLKDNVLSSMLRLHTVES---GDINVVAASGSLTRKVKLLFRASFYFKEFATRTFT 2084
Query 2129 ---TTSNCAKRLAQRV---------FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTT-- 2174
+C K + + + +++ +F L + +K + ++ S T
Sbjct 2085 ATTAVGSCIKSVVRHLGVTKGILTGCFSFVKMLFMLPLAYFSDSKLGTTEVKVSALKTAG 2144
Query 2175 -IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSN 2233
+ N VK +D ++ ++ + + + L + L S+ + VL S+
Sbjct 2145 VVTGNVVKQCCTAAVDLSMDKLRRVDWKSTLRLLLMLCTTMVLLSSVYHLYVFNQVLSSD 2204
Query 2234 -------------------FGAPSYCNGVRELY-LNSSNVTTMDFCEG-SFPCSICLSGL 2272
G S C+G+ Y NS +V T FC S C+ CL
Sbjct 2205 VMFEDAQGLKKFYKEVRAYLGISSACDGLASAYRANSFDVPT--FCANRSAMCNWCLISQ 2262
Query 2273 DSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGY-- 2330
DS+ YPAL+ +Q +S Y L++ L A E LAYML+T F L L+ + FF
Sbjct 2263 DSITHYPALKMVQTHLSHYVLNIDWLWFAFETGLAYMLYTSAFNWLLLAGTLHYFFAQTS 2322
Query 2331 ----FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTC 2386
+ S+ + S W I P++ +VRMY A + + K Y H+++GC + C
Sbjct 2323 IFVDWRSYNYAVSSAFWLFTHI----PMAGLVRMYNLLACLWLLRKFYQHVINGCKDTAC 2378
Query 2387 MMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEV 2446
++CYKRNR TRVE +T+V G KR+FY+ ANGG FC+ HNWNC++CDT G+TFI +EV
Sbjct 2379 LLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDTAGVGNTFICEEV 2438
Query 2447 ARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLR- 2505
A DL+ +RPIN TD+S Y VDSV VK + + + GQ YER PL F NLD L+
Sbjct 2439 ANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPFYERFPLCAFTNLDKLKF 2498
Query 2506 ---ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTE 2562
T G N I++D + ES ++SA VYYSQ++C+ ILL+D +LV+ VGDS+E
Sbjct 2499 KEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLVTSVGDSSE 2558
Query 2563 VSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDT 2621
++ KMFD++V++F + ++V +KL+ L++TA + +G VL+TF+ AAR V++
Sbjct 2559 IATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAARGPAGVES 2618
Query 2622 DVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVA 2681
DV+T ++++ ++ +H D+++T +S NN++ +Y K ++++ DLG+ IDCNA +N V
Sbjct 2619 DVETNEIVDSVQYAHKHDIQITNESYNNYVPSYVKPDSVSTSDLGSLIDCNAASVNQIVL 2678
Query 2682 KSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKIS---LK 2738
++ N + IWN YM LS+ L++QIR A +K N+ FRLT + R N+++ + + +
Sbjct 2679 RNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSVRFTANKIV 2738
Query 2739 GGK------IVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDG 2792
GG + K + AT++ L A++ Y+ +P ++ + Y + I+ +K + +G
Sbjct 2739 GGAPTWFNALRDFTLKGYVLATIIVFLCAVLMYLCLPTFSMVPVEFYEDRILDFKVLDNG 2798
Query 2793 VTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKSCPVVAAIITREIGFIVPGLPGTVL 2851
+ RD+ D CFANKH F W+ + GG Y N +CP+ A+I G +P +P T L
Sbjct 2799 IIRDVNPDDKCFANKHRSFTQWYHEHVGGVYDNSITCPLTVAVIAGVAGARIPDVP-TTL 2857
Query 2852 RAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCY 2911
+N + F+ RVF+ G++CYTP I Y F+ S C+L +ECT+F+DA G+ PYC+
Sbjct 2858 AWVNNQIIFFVSRVFANTGSVCYTPIDEIPYKSFSDSGCILPSECTMFRDAEGRMTPYCH 2917
Query 2912 DTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE 2970
D +L G+ +YS++RP RY L DG++ I+FP E ++R+ T +YCR G+CE ++
Sbjct 2918 DPTVLPGAFAYSQMRPHVRYDLYDGNMFIKFPEVVFESTLRITRTLSTQYCRFGSCEYAQ 2977
Query 2971 VGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGII 3030
G+C++T+G W + N+H+ GV+CG D ++++ + L QP+ ++ S+V G +
Sbjct 2978 EGVCITTNGSWAIFNDHHLNRPGVYCGSDFIDIVRRLAVSLFQPITYFQLTTSLVLGIGL 3037
Query 3031 AILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT 3090
+T YY K +R F +Y + +++ +C V + Y+ Y Y T
Sbjct 3038 CAFLTLLFYYINKVKRAFADYTQCAVIAVVAAVLNSLCICFVASIPLCIVPYTALYYYAT 3097
Query 3091 FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV--MFNGVT 3148
FYFTN+ +F+ H+ W+ MF PIVP W+T +Y + +H W + +K V +G
Sbjct 3098 FYFTNEPAFIMHVSWYIMFGPIVPIWMTCVYTVAMCFRHFFWVLAYFSKKHVEVFTDGKL 3157
Query 3149 FSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAAC 3208
+F++AA F++NK+ Y LR+ L Y+R+L L+NKYKYFSGA++T +YREAA
Sbjct 3158 NCSFQDAASNIFVINKDTYAALRNS--LTNDAYSRFLGLFNKYKYFSGAMETAAYREAAA 3215
Query 3209 CHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLN 3268
CHLAKAL +S +G+D+LYQPP SITS VLQSG KM+ PSG VE CMVQVTCG+ TLN
Sbjct 3216 CHLAKALQTYSETGSDLLYQPPNCSITSGVLQSGLVKMSHPSGDVEACMVQVTCGSMTLN 3275
Query 3269 GLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVIGHSMQNC 3325
GLWLD+TV+CPRHV+C A+ + +PNY+ LLI +NHSF VQ LRV+GH+MQ
Sbjct 3276 GLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRVVGHAMQGT 3335
Query 3326 LLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSC 3385
LL+L VD +NP TP Y F ++PG FSVLACYNG P+G + MRPN+TIKGSFL GSC
Sbjct 3336 LLKLTVDVANPSTPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSC 3395
Query 3386 GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVL 3445
GSVG+ + ++FCYMH MEL G H G+ +G YG F+D+Q Q TD ++NV+
Sbjct 3396 GSVGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDKYCSVNVV 3455
Query 3446 AWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY-EPLTQDHVDILGPLSAQTGIAVLDM 3504
AWLYAA++NG WF+ T++ FN A+ + E + VD+L + +TG+A+ +
Sbjct 3456 AWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSVDML---AVKTGVAIEQL 3512
Query 3505 CAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTF 3564
A+++L G G+ ILGST+LEDEFTP DV Q GV Q +K+ GT HW+ T
Sbjct 3513 LYAIQQLY-TGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQSGVRKVTYGTAHWLFATL 3571
Query 3565 LTSLLILVQSTQWSLFFFVYEN---AFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSL 3621
+++ +I++Q+T+++L+ +++E P MA MLLVKHKH FL LFLLP
Sbjct 3572 VSTYVIILQATKFTLWNYLFETIPTQLFPLLFVTMAFV---MLLVKHKHTFLTLFLLPVA 3628
Query 3622 ATVAYFNMVYMP----ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTV 3677
+ Y N+VY P +S ++ + WL + + D +Y S ++L+++ R
Sbjct 3629 ICLTYANIVYEPTTPISSALIAVANWLAPTNAYMRTTH-TDIGVYISMSLVLVIVVKRLY 3687
Query 3678 YDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVF 3737
+ L + + +Y G A I+ V ++TS+Y+ V + LA+ +
Sbjct 3688 NPSLSNFALALCSGVMWLYTYSIGEA-SSPIAYLVFVTTLTSDYTITVFVTVNLAKVCTY 3746
Query 3738 VCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEF 3797
Y P L + ++ I+L+Y LG+ C CYFG+F LLN R +GVYD+ VSTQEF
Sbjct 3747 AIFAYSPQLTLVFPEVKMILLLYTCLGFMCTCYFGVFSLLNLKLRAPMGVYDFKVSTQEF 3806
Query 3798 RYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLR 3857
R+M + L P++S +A LN KL+GIGG PCIKVA +QSK++D+KCTSVVLLSVLQQL
Sbjct 3807 RFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQSKLTDLKCTSVVLLSVLQQLH 3866
Query 3858 VESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRAT 3917
+E++S+ WA CV+ HNDIL A D +EAFEK VSL + L++ G VD++ L ++ D +
Sbjct 3867 LEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFDTPSV 3926
Query 3918 LQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAAMQR 3976
LQA SEFS L ++A AQ+AY++A+ +GD S VLK L+K++N+AK+ +++D A+ R
Sbjct 3927 LQATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDKAVAR 3986
Query 3977 KLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPL 4036
KLE+MADQAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN II+NAR+GC+PL
Sbjct 3987 KLERMADQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGIISNARNGCIPL 4046
Query 4037 NIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNS 4096
++IPL + KL VV+PD+ + + YA ALW+I + + D++IV+ S++ +D++
Sbjct 4047 SVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDV-VDSN 4105
Query 4097 PNLAWPLIVTALRAN-SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGG 4155
NL WPL++ RA+ SAVKLQNNE+ P L+ M +AG QT C + ++LAYY +G
Sbjct 4106 ENLTWPLVLECTRASTSAVKLQNNEIKPSGLKTMVVSAGQEQTNC-NTSSLAYYEPVQGR 4164
Query 4156 RFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLN 4215
+ ++ALLSD+ LKWAR DG ++ EL+PPC+F+ PKGP+++YLYF+K LNNL+
Sbjct 4165 KMLMALLSDNAYLKWARVEGKDGFVSV--ELQPPCKFLIAGPKGPEIRYLYFVKNLNNLH 4222
Query 4216 RGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKML 4275
RG VLG +AATVRLQAG+ TE +NS+VLS F VDP KAY D++ +GG P+TNCVKML
Sbjct 4223 RGQVLGHIAATVRLQAGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNCVKML 4282
Query 4276 CTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCAN 4335
TGTG AI+V PE+ DQE++GGAS CLYCR HI+HP+ G C KGK+VQIP C
Sbjct 4283 TPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPAQCVR 4342
Query 4336 DPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFL 4377
DPVGF L NT C VC W GYGC+CD LR+ + + S FL
Sbjct 4343 DPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQSKDSNFL 4384
Score = 305 bits (781), Expect = 6e-81, Method: Compositional matrix adjust.
Identities = 307/1186 (26%), Positives = 515/1186 (43%), Gaps = 155/1186 (13%)
Query 101 GITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQN 160
G +G+ P+ E +N+LLRK G GG+ Y Y+ + + ++D+E +
Sbjct 123 GKPIGMFFPYDIELVTGKQNILLRKYGR---GGYHY--TPFHYERDNTSCPEWMDDFEAD 177
Query 161 WNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG-KSMCTLSEQL 219
K+ L++L GG VT VD CG DG P+ +A+ G + + +
Sbjct 178 PKGKYAQNLLKKLI----GGDVTP-VDQYMCGVDGKPISAYAFLMAKDGITKLADVEADV 232
Query 220 DYIESKRGVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNS 279
G +++ + + W ER D Y Q+ F I S + D + P + F L
Sbjct 233 AARADDEGFITLKNNLYRLVWHVERKDVPYPKQSIFTINSVVQKDGVENTPPHY-FTLGC 291
Query 280 KVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNN---MHLSTLMKCNHCDEVSWQTCDF 336
K+ + PR + + + +Y + N ++ S ++C C SW T +
Sbjct 292 KILTLTPRNKWSGVSDLSLKQKLLYTFYGKESLENPTYIYHSAFIECGSCGNDSWLTGNA 351
Query 337 LKATCEHCGTENLVIEGPT-TCGYLPTNAVVKMPCPACQDPEIGP--EHSVADYHNHSNI 393
++ CG + + G + NA++ CP + +HSVA ++ +
Sbjct 352 IQGFACGCGASYTANDVEVQSSGMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSE 411
Query 394 ETRLRKGGR--TRCFGGCVFAYVGCYNKRAYWVPRASADIG----SGHTGITG--DNVET 445
+ + T FGG +AY GC Y+VPRA + + S TG TG + V
Sbjct 412 RCNVIADSKSFTLIFGGVAYAYFGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQ 471
Query 446 LNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVES 505
+ LE + + ++N VG+F +N+ V IL+ + + +K + + +
Sbjct 472 IANMFLE---QTQHSLNFVGEFVVNDVVLAILSGTTTNVDKIRQLLKGVTLDKLRDYLAD 528
Query 506 CGNYKVTKGKPVKGAWNIG----QQRSVLTP---LCGFPSQAAGV------IRSIFARTL 552
+ VT G + A N+G Q ++ P L G V + + TL
Sbjct 529 Y-DVAVTAGPFMDNAINVGGTGLQYAAITAPYVVLTGLGESFKKVATIPYKVCNSVKDTL 587
Query 553 DAANHSIPDLQRAAVTILD-GISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQ 611
HS+ L R +D G+S S L D + DL SV ++ L +T
Sbjct 588 TYYAHSV--LYRVFPYDMDSGVSSFSELLFDCV----DL---SVASTYFLVRLLQDKTGD 638
Query 612 WLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNI 671
++S ++ + + + + A FL D + + + + V + +
Sbjct 639 FMSTIITSCQTAVSKLLDTCFEATEATFNFLLDLAGLFRIFLRNAYVYTSQGFVVVNGKV 698
Query 672 KDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLG--EVFIAQSKGLYRQCIRGK---EQ 726
VK +D++NK +++ +V+ AG+ + ++ E I S Y + K +
Sbjct 699 STLVKQVLDLLNKGMQLLHTKVSWAGSNISAVIYSGRESLIFPSGTYYCVTTKAKSVQQD 758
Query 727 LQLLMPLK-APKEVTFLEGDSHDTVLTSE------EVVLKNGELEALETPVDSFTNGAIV 779
L +++P + + K++ L+ + T ++ E V+ E + +P IV
Sbjct 759 LDVILPGEFSKKQLGLLQPTDNSTTVSVTVSSNMVETVVGQLEQTNMHSP------DVIV 812
Query 780 GTPVCVNGLMLLEIKDKEQYCALSPGLL---ATNNVFRLKGGAPIKGVTFGEDTVWEVQG 836
G V ++ + + K+++ + A P A +FRLKGGAP+K V FG D V EV
Sbjct 813 GDYVIISEKLFVRSKEEDGF-AFYPACTNGHAVPTLFRLKGGAPVKKVAFGGDQVHEVAA 871
Query 837 YKNVRITFELDERVDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMG 895
++V + + + +D +L + + V+ + EFA VV E V L LL M
Sbjct 872 VRSVTVEYNIHAVLDTLLASSSLRTFVVDKSLSIEEFADVVKEQVSDLL---VKLLRGMP 928
Query 896 I---DLDEWSVATFYLFDDAGEENFSSRMYCSFYPP--DEE---------EEDDAECEEE 941
I DLD++ A Y F+ G+ ++SS M S +P DEE EE ++EC E
Sbjct 929 IPDFDLDDFIDAPCYCFNAEGDASWSSTMIFSLHPVECDEECSEVEASDLEEGESECISE 988
Query 942 EIDETCEHEYGTEDDY------QGLPLEFGASAETVRVEEEEE--------------EDW 981
E + + DD + PL+ A T V+EE + D
Sbjct 989 TSTEQVDVSHEISDDEWAAAVDEAFPLD-EAEDVTESVQEEAQPVEVPVEDIAQVVIADT 1047
Query 982 LDDT---TEQSEIEPEPEPTPEEP------------------------------------ 1002
L +T ++ E+ P+ P EP
Sbjct 1048 LQETPVVSDTVEVPPQVVKLPSEPQTIQPEVKEVAPVYEADTEQTQSVTVKPKRLRKKRN 1107
Query 1003 VNQFTGYLK--LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGA 1060
V+ + + +T+ V I D ++ A+ V+VNAAN HLKHGGG+AGA+N A+ GA
Sbjct 1108 VDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHLKHGGGIAGAINAASKGA 1167
Query 1061 MQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQD 1120
+QKESD+YI GPL VG S LL GH+LAK LHVVGP+ A +D+ LL Y+ N+
Sbjct 1168 VQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYP 1227
Query 1121 ILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVM 1166
+++ PL+SAGIFG KP S ++ +T+V + VN + +Y+ + +
Sbjct 1228 LVVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVNSQDVYKSLTI 1273
>sp|P0C6T9|R1A_CVBLU Replicase polyprotein 1a OS=Bovine coronavirus
(strain 98TXSF-110-LUN) OX=233264 GN=1a PE=3 SV=1
Length=4383
Score = 1897 bits (4915), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1105/2894 (38%), Positives = 1636/2894 (57%), Gaps = 133/2894 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + +G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGENFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
++ ES S+E+ I+ ++ K +V +VI+ +K + L D+
Sbjct 2025 IS-ESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDM 2077
Query 2076 YVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTS 2131
++ ++ N+LS+A+ + TI G+ + S+P + L +KP
Sbjct 2078 WLTGCRYVVRTANDLSMAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF-------- 2128
Query 2132 NCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLD 2189
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVAL 2181
Query 2190 AGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELY 2247
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2182 AFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWI 2241
Query 2248 LNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-L 2293
++ ++ T+ +C GS C CL+G D LD+Y A++ +Q +
Sbjct 2242 KSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFV 2301
Query 2294 DLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQ 2350
D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2302 DYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLAN 2361
Query 2351 MAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRS 2410
M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2362 MLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKPGCLFCYKRNRSLRVKCSTIVGGMIRY 2421
Query 2411 FYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDS 2470
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2422 YDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTD 2481
Query 2471 VAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESA 2530
V + L++++ GQ+TY+ S FV+ NL + KG ++V+V + + D++
Sbjct 2482 VKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVENDA--DKAN 2539
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+
Sbjct 2540 FLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALI 2599
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNN 2649
ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN
Sbjct 2600 ATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNN 2659
Query 2650 FMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++ A
Sbjct 2660 LVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKA 2719
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI--- 2766
K + +LT V+V+TT SLKGG + S +C L +LVC+I
Sbjct 2720 CCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFLLSLVCFIGLW 2772
Query 2767 -VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYK 2823
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2773 CLMPTYTVHKSDFQLPVYTSYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYS 2832
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYS 2883
N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I YS
Sbjct 2833 NSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYS 2891
Query 2884 DFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFP 2942
+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2892 NFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFIRFP 2951
Query 2943 NTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMN 3002
EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +
Sbjct 2952 EVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFD 3011
Query 3003 LIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLF 3062
LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N +++
Sbjct 3012 LIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVW 3071
Query 3063 LMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYV 3122
++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+
Sbjct 3072 CVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYI 3131
Query 3123 FCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
+ H W F Y R R+ + + TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3132 SVVVSNHAFWVF-AYCR-RLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T + + +
Sbjct 3545 GIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKT 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLNGFAV 4382
QS D + FLNGF V
Sbjct 4369 QSKD-TNFLNGFGV 4381
Score = 83.6 bits (205), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 73.2 bits (178), Expect = 8e-11, Method: Compositional matrix adjust.
Identities = 77/286 (27%), Positives = 129/286 (45%), Gaps = 36/286 (13%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTPKTIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVVDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 936 KLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD----- 986
Query 960 LPLEFGASAETVRVEEEEE-----EDWLDD----TTEQSEIEPEPE 996
L ++ E E+EE ED LDD T S++E + E
Sbjct 987 --LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVE 1030
>sp|P0C6T8|R1A_CVBEN Replicase polyprotein 1a OS=Bovine coronavirus
(strain 98TXSF-110-ENT) OX=233262 GN=1a PE=3 SV=1
Length=4383
Score = 1895 bits (4908), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1105/2894 (38%), Positives = 1635/2894 (56%), Gaps = 133/2894 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYNPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
++ ES S+E+ I+ ++ K +V +VI+ +K + L D+
Sbjct 2025 IS-ESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDM 2077
Query 2076 YVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTS 2131
++ ++ N LS+A+ + TI G+ + S+P + L +KP
Sbjct 2078 WLTGCRYVVRTANALSMAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF-------- 2128
Query 2132 NCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLD 2189
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVAL 2181
Query 2190 AGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELY 2247
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2182 AFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWI 2241
Query 2248 LNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-L 2293
++ ++ T+ +C GS C CL+G D LD+Y A++ +Q +
Sbjct 2242 KSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFV 2301
Query 2294 DLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQ 2350
D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2302 DYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLAN 2361
Query 2351 MAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRS 2410
M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2362 MLPAHVFMRFYIIIASFIKLFILFRHVAYGCSKPGCLFCYKRNRSLRVKCSTIVGGMIRY 2421
Query 2411 FYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDS 2470
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2422 YDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTD 2481
Query 2471 VAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESA 2530
V + L++++ GQ+TY+ S FV+ NL + KG ++V+V + + D++
Sbjct 2482 VKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVENDA--DKAN 2539
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+
Sbjct 2540 FLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALI 2599
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNN 2649
ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN
Sbjct 2600 ATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNN 2659
Query 2650 FMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++ A
Sbjct 2660 LVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKA 2719
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI--- 2766
K + +LT V+V+TT SLKGG + S +C L +LVC+I
Sbjct 2720 CCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFLLSLVCFIGLW 2772
Query 2767 -VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYK 2823
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2773 CLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYS 2832
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYS 2883
N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I YS
Sbjct 2833 NSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYS 2891
Query 2884 DFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFP 2942
+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2892 NFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFIRFP 2951
Query 2943 NTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMN 3002
EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +
Sbjct 2952 EVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFD 3011
Query 3003 LIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLF 3062
LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N +++
Sbjct 3012 LIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVW 3071
Query 3063 LMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYV 3122
++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+
Sbjct 3072 CVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYI 3131
Query 3123 FCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
+ H W F Y R R+ + + TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3132 SVVVSNHAFWVF-AYCR-RLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T + + +
Sbjct 3545 GIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKT 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLNGFAV 4382
QS D + FLNGF V
Sbjct 4369 QSKD-TNFLNGFGV 4381
Score = 83.2 bits (204), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 72.4 bits (176), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 77/286 (27%), Positives = 129/286 (45%), Gaps = 36/286 (13%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTPKTIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 936 KLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD----- 986
Query 960 LPLEFGASAETVRVEEEEE-----EDWLDD----TTEQSEIEPEPE 996
L ++ E E+EE ED LDD T S++E + E
Sbjct 987 --LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVE 1030
>sp|P0C6U7|R1A_CVHOC Replicase polyprotein 1a OS=Human coronavirus
OC43 OX=31631 GN=1a PE=1 SV=1
Length=4383
Score = 1890 bits (4897), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1106/2894 (38%), Positives = 1626/2894 (56%), Gaps = 133/2894 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCFKWQVVVNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L + F QEA+ R+G A F AL+LA G+ D R+ + + +L A
Sbjct 1682 SLHLTFKIVQWQEAWLEFRSGRPARFVALVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TG++AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGLDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFIGD-NVGHYVHVKCEQSYQLYDASNVKKVTDVTGKLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E +T +P GDVV + Y ++
Sbjct 1917 DGVYTNFKLIGHTV--CDSLNSKLGFDSSKEFVEYKITEWPTATGDVVLANDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLA 2017
+G KP++W ++ K + T+ R L VD N F+VL V+D + +
Sbjct 1975 RGCITFGKPVIWLSHE---KASLNSLTYFNRPLL----VD-DNKFDVLKVDDVDDSGDSS 2026
Query 2018 CESQQPTSE-EVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAY 2076
+ T E +++ ++K +V +VI+ K + L D+ +
Sbjct 2027 ESGAKETKEINIIKLSGVKKPF--------KVEDSVIVNDDTSETKYVKSLSIVDVYDMW 2078
Query 2077 VENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTSN 2132
+ ++ N LS A+ + TI G+ + S+P + L +KP A+
Sbjct 2079 LTGCKYVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKP-----AVNVVK 2132
Query 2133 CAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGI 2192
+ FN ++ ++F LLF + + T IA K KL A
Sbjct 2133 AVRNKTSACFN-FIKWLFVLLFGWIKISADN----KVIYTTEIAS---KLTCKLVALAFK 2184
Query 2193 NYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELYLNS 2250
N + K+S + A + + + + I F L G P++ + + N+
Sbjct 2185 NAFLTFKWSMVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWIKNT 2244
Query 2251 SNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-LDLT 2296
++ T+ +C GS C CL+G D LD+Y A++ +Q +D T
Sbjct 2245 FSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFVDYT 2304
Query 2297 -ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAP 2353
+L + E +++Y L+T +FY L +Q+ + F+ ++ W ++++ M P
Sbjct 2305 GVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSFRLLVALANMLP 2364
Query 2354 VSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYV 2413
+R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R + V
Sbjct 2365 AHVFMRFYIIIASFIKLFSLFKHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIRYYDV 2424
Query 2414 YANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAV 2473
ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V V
Sbjct 2425 MANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTDVKQ 2484
Query 2474 KNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKS 2533
++ L++D+ GQ+ Y+ S FV+ NL + K ++V+V + + D++ +
Sbjct 2485 VGCSMRLFYDRDGQRIYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKANFLN 2542
Query 2534 ASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATA 2593
A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+ATA
Sbjct 2543 AAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALIATA 2602
Query 2594 HSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFML 2652
HS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN +
Sbjct 2603 HSSIKQGTQIYKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNNLVP 2662
Query 2653 TYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKK 2712
TY K +N+ DLG I +A+H+ VAK VS IW+V + S + +++ A K
Sbjct 2663 TYLKSDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQFSSDFQHKLKKACCK 2722
Query 2713 NNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI----VM 2768
+ +LT V+V+TT SLKGG + S +C + +LVC+I +M
Sbjct 2723 TGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGLWCLM 2775
Query 2769 PVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDK 2826
P +T+ D YK + +GV RD+ D CFANK FD W+ G Y N
Sbjct 2776 PTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSM 2835
Query 2827 SCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFA 2886
+CP+V A+I ++ G V +P VLR LHF+ SA G CYTP I YS+F
Sbjct 2836 ACPIVVAVIDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYSNFY 2894
Query 2887 TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTY 2945
S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2895 ASGCVLSSACTMFTMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVL 2954
Query 2946 LEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIA 3005
EG VRVV T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +LI
Sbjct 2955 REGLVRVVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIY 3014
Query 3006 NIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMS 3065
+F L QPV L ++AS +AG I+A++V YY +K +R FG+Y VV N +++ ++
Sbjct 3015 QLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVIVWCVN 3074
Query 3066 FTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCI 3125
F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+ +
Sbjct 3075 FMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYIAVV 3134
Query 3126 SLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
H W F+ Y RK V +G TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3135 VSNHAFWVFS-YCRKLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS-GADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+N+ G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCVVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + M+ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMRGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N LAWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPIQDYIQSVNFLAWLYAAILNNCNWFIQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++ KGT W++ TFL S I+ +W++F +V N F T + + +
Sbjct 3545 GIKLQSKRTRLFKGTVCWIMASTFLFS-CIITAFVKWTMFMYVTTNMF-SITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L +++ P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYITPVLFTLLYNNYLVVYKHTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + +I++ Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLVGMVFVTLRSINHDLFSFIMFVGRLISVFSLWYKGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M +A+ I +V V L F ++ ++L Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTVLSMAVAKVIAKWVAVNV--LYFTDIPQIKIVLLCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D + AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A +G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARFSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ +KLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVAKKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLNIIVPDKSVYDQIVDNIYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRYNEVSATVLQNNELMPAKLKI 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDAKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCRVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLNGFAV 4382
QS D + FLNGF V
Sbjct 4369 QSKD-TNFLNGFGV 4381
Score = 83.2 bits (204), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 81/155 (52%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ + +K
Sbjct 1273 ITPNVCFVKGDIIKVSKLVKAEVVVNPANGHMVHGGGVAKAIAVAAGQQFVKETTNMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++FN+ D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYVLLERVYKHFNNYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 67.4 bits (163), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 74/284 (26%), Positives = 126/284 (44%), Gaps = 26/284 (9%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDDHVGLLDQAWRVPCAG--RRVTFKEQPTVKEIISMPKIIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDNDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ +LFD+AGEE F+ ++YC+F P E+DD ++E+ E E +
Sbjct 936 KLEDNPLFLFDEAGEEVFAPKLYCAFTAP---EDDDF------LEESDVEEDDVEGEETD 986
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV 1003
L + A V E+EE + L+DT + + EE V
Sbjct 987 LTIT-SAGQPCVASEQEESSEVLEDTLDDGPSVETSDSQVEEDV 1029
>sp|P0C6W8|R1AB_CVBLU Replicase polyprotein 1ab OS=Bovine coronavirus
(strain 98TXSF-110-LUN) OX=233264 GN=rep PE=3 SV=1
Length=7094
Score = 1889 bits (4893), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1102/2890 (38%), Positives = 1633/2890 (57%), Gaps = 133/2890 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + +G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGENFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
++ ES S+E+ I+ ++ K +V +VI+ +K + L D+
Sbjct 2025 IS-ESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDM 2077
Query 2076 YVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTS 2131
++ ++ N+LS+A+ + TI G+ + S+P + L +KP
Sbjct 2078 WLTGCRYVVRTANDLSMAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF-------- 2128
Query 2132 NCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLD 2189
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVAL 2181
Query 2190 AGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELY 2247
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2182 AFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWI 2241
Query 2248 LNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-L 2293
++ ++ T+ +C GS C CL+G D LD+Y A++ +Q +
Sbjct 2242 KSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFV 2301
Query 2294 DLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQ 2350
D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2302 DYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLAN 2361
Query 2351 MAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRS 2410
M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2362 MLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKPGCLFCYKRNRSLRVKCSTIVGGMIRY 2421
Query 2411 FYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDS 2470
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2422 YDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTD 2481
Query 2471 VAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESA 2530
V + L++++ GQ+TY+ S FV+ NL + KG ++V+V + + D++
Sbjct 2482 VKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVENDA--DKAN 2539
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+
Sbjct 2540 FLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALI 2599
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNN 2649
ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN
Sbjct 2600 ATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNN 2659
Query 2650 FMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++ A
Sbjct 2660 LVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKA 2719
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI--- 2766
K + +LT V+V+TT SLKGG + S +C L +LVC+I
Sbjct 2720 CCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFLLSLVCFIGLW 2772
Query 2767 -VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYK 2823
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2773 CLMPTYTVHKSDFQLPVYTSYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYS 2832
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYS 2883
N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I YS
Sbjct 2833 NSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYS 2891
Query 2884 DFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFP 2942
+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2892 NFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFIRFP 2951
Query 2943 NTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMN 3002
EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +
Sbjct 2952 EVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFD 3011
Query 3003 LIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLF 3062
LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N +++
Sbjct 3012 LIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVW 3071
Query 3063 LMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYV 3122
++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+
Sbjct 3072 CVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYI 3131
Query 3123 FCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
+ H W F Y R R+ + + TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3132 SVVVSNHAFWVF-AYCR-RLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T + + +
Sbjct 3545 GIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKT 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLN 4378
QS D + FLN
Sbjct 4369 QSKD-TNFLN 4377
Score = 83.6 bits (205), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 73.2 bits (178), Expect = 7e-11, Method: Compositional matrix adjust.
Identities = 77/286 (27%), Positives = 129/286 (45%), Gaps = 36/286 (13%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTPKTIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVVDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 936 KLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD----- 986
Query 960 LPLEFGASAETVRVEEEEE-----EDWLDD----TTEQSEIEPEPE 996
L ++ E E+EE ED LDD T S++E + E
Sbjct 987 --LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVE 1030
>sp|P0C6W7|R1AB_CVBEN Replicase polyprotein 1ab OS=Bovine coronavirus
(strain 98TXSF-110-ENT) OX=233262 GN=rep PE=3 SV=1
Length=7094
Score = 1887 bits (4889), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1102/2890 (38%), Positives = 1632/2890 (56%), Gaps = 133/2890 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYNPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
++ ES S+E+ I+ ++ K +V +VI+ +K + L D+
Sbjct 2025 IS-ESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDM 2077
Query 2076 YVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTS 2131
++ ++ N LS+A+ + TI G+ + S+P + L +KP
Sbjct 2078 WLTGCRYVVRTANALSMAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF-------- 2128
Query 2132 NCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLD 2189
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVAL 2181
Query 2190 AGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELY 2247
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2182 AFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWI 2241
Query 2248 LNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-L 2293
++ ++ T+ +C GS C CL+G D LD+Y A++ +Q +
Sbjct 2242 KSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFV 2301
Query 2294 DLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQ 2350
D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2302 DYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLAN 2361
Query 2351 MAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRS 2410
M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2362 MLPAHVFMRFYIIIASFIKLFILFRHVAYGCSKPGCLFCYKRNRSLRVKCSTIVGGMIRY 2421
Query 2411 FYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDS 2470
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2422 YDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTD 2481
Query 2471 VAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESA 2530
V + L++++ GQ+TY+ S FV+ NL + KG ++V+V + + D++
Sbjct 2482 VKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVENDA--DKAN 2539
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+
Sbjct 2540 FLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALI 2599
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNN 2649
ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN
Sbjct 2600 ATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNN 2659
Query 2650 FMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++ A
Sbjct 2660 LVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKA 2719
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI--- 2766
K + +LT V+V+TT SLKGG + S +C L +LVC+I
Sbjct 2720 CCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFLLSLVCFIGLW 2772
Query 2767 -VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYK 2823
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2773 CLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYS 2832
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYS 2883
N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I YS
Sbjct 2833 NSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYS 2891
Query 2884 DFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFP 2942
+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2892 NFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFIRFP 2951
Query 2943 NTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMN 3002
EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +
Sbjct 2952 EVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFD 3011
Query 3003 LIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLF 3062
LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N +++
Sbjct 3012 LIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIVW 3071
Query 3063 LMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYV 3122
++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+
Sbjct 3072 CVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYI 3131
Query 3123 FCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
+ H W F Y R R+ + + TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3132 SVVVSNHAFWVF-AYCR-RLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T + + +
Sbjct 3545 GIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKT 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLN 4378
QS D + FLN
Sbjct 4369 QSKD-TNFLN 4377
Score = 83.6 bits (205), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 78/155 (50%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 72.8 bits (177), Expect = 9e-11, Method: Compositional matrix adjust.
Identities = 77/286 (27%), Positives = 129/286 (45%), Gaps = 36/286 (13%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTPKTIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 936 KLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD----- 986
Query 960 LPLEFGASAETVRVEEEEE-----EDWLDD----TTEQSEIEPEPE 996
L ++ E E+EE ED LDD T S++E + E
Sbjct 987 --LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVE 1030
>sp|P0C6U1|R1A_CVBQ Replicase polyprotein 1a OS=Bovine coronavirus
(strain Quebec) OX=11133 GN=1a PE=3 SV=1
Length=4383
Score = 1884 bits (4881), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1100/2898 (38%), Positives = 1628/2898 (56%), Gaps = 141/2898 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LA-CESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMA 2074
++ ++++P +++ ++K +V +VI+ +K + L D+
Sbjct 2025 ISESDAKEPKEINIIKLSGVKKPF--------KVEDSVIVNDDTSEIKYVKSLSIVDVYD 2076
Query 2075 AYVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITT 2130
++ ++ N LS A+ + TI G+ + S+P + L +KP
Sbjct 2077 MWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF------- 2128
Query 2131 SNCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCL 2188
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 -NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVA 2180
Query 2189 DAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVREL 2246
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2181 LAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIVQW 2240
Query 2247 YLNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK- 2292
N+ ++ T+ +C GS C CL+G D LD+Y A++ +Q
Sbjct 2241 IKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAF 2300
Query 2293 LDLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIV 2349
+D T +L + E +++Y L+T +FY L +Q+ + + ++ W + ++S+
Sbjct 2301 VDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELLMLSTLHWSVRLLVSLA 2360
Query 2350 QMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKR 2409
M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2361 NMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIR 2420
Query 2410 SFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVD 2469
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2421 YYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVT 2480
Query 2470 SVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDES 2529
V + L++D+ GQ+TY+ S FV+ NL + K ++V+V + + D++
Sbjct 2481 DVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKA 2538
Query 2530 ASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKAL 2589
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL
Sbjct 2539 NFLNAAVFYAQSLFRPILMVDKILITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNAL 2598
Query 2590 VATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCN 2648
+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCN
Sbjct 2599 IATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCN 2658
Query 2649 NFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRS 2708
N + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++
Sbjct 2659 NLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKK 2718
Query 2709 AAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI-- 2766
A K + LT V+V+TT SLKGG + S +C + +LVC+I
Sbjct 2719 ACCKTGLKLELTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGL 2771
Query 2767 --VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SY 2822
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2772 WCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYY 2831
Query 2823 KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEY 2882
N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I Y
Sbjct 2832 SNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISY 2890
Query 2883 SDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQF 2941
S+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+
Sbjct 2891 SNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRL 2950
Query 2942 PNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAM 3001
P EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2951 PEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVF 3010
Query 3002 NLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALL 3061
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N ++
Sbjct 3011 DLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLGFYYLIKLKRAFGDYTSIVFVNVIV 3070
Query 3062 FLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIY 3121
+ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y
Sbjct 3071 WCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLY 3130
Query 3122 VFCISLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+ + H W F+ Y R+ V +G TFEE AL TF++ K+ Y KL++ L
Sbjct 3131 ISVVVSNHAFWVFS-YCRQLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS-GADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+N+ G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIM 3596
+Q +G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T +
Sbjct 3541 QQLAGIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCAL 3598
Query 3597 AIAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYR 3655
+ + AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3599 CVISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YT 3657
Query 3656 LKDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALV 3714
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++
Sbjct 3658 YTDEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--ML 3715
Query 3715 ISVTSNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGL 3773
S+ Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GL
Sbjct 3716 ASLFGTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGL 3773
Query 3774 FCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVA 3833
F L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3774 FSLMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVS 3833
Query 3834 TVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLS 3893
QSK++DVKC + LL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL
Sbjct 3834 QFQSKLTDVKCANGGLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLI 3893
Query 3894 VLLSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN 3947
VL + AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++
Sbjct 3894 VLFANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSS 3953
Query 3948 GDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAM 4006
G + + LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+
Sbjct 3954 GSANQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSAL 4013
Query 4007 QTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTF 4066
QTMLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D
Sbjct 4014 QTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYV 4073
Query 4067 TYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPV 4124
TYA +W+IQ + D+D QL EI S + WPL++ A R N SA LQNNEL P
Sbjct 4074 TYAGNVWQIQTIQDSDGTNKQLHEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPA 4129
Query 4125 ALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYT 4184
L+ +G QT T YYNNS G+ V A+LSD LK+ + K DG +
Sbjct 4130 KLKTQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-L 4186
Query 4185 ELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVL 4244
EL+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++L
Sbjct 4187 ELDPPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSIL 4246
Query 4245 SFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCC 4304
S CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C
Sbjct 4247 SLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVC 4306
Query 4305 LYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
+YCR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4307 IYCRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-T 4364
Query 4365 EPLMQSADASTFLNGFAV 4382
+ +QS D + FLNGF V
Sbjct 4365 DTTVQSKD-TNFLNGFGV 4381
Score = 84.3 bits (207), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 79/155 (51%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 66.2 bits (160), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 54/189 (29%), Positives = 90/189 (48%), Gaps = 17/189 (9%)
Query 822 KGVTFGED-TVWEVQGY-KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEA 879
+ VTF E TV E+ K +++ +ELD+ + +LN C + V+ ++ EF VV +A
Sbjct 853 RCVTFKEQPTVNEIASTPKTIKVFYELDKDFNTILNTACGEFEVDDTVDMEEFYAVVIDA 912
Query 880 VVKTLQPVSDLL---TNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
+ + L P +L + L + + +LFD+AGEE + ++YC+F P EDD
Sbjct 913 IEEKLSPCKELEGVGAKVSAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDD 968
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEP 995
EE ++E T+ L ++ E V E+EE + L+DT +
Sbjct 969 FLEESGVEEDDVEGEETD-------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETS 1021
Query 996 EPTPEEPVN 1004
+ EE V
Sbjct 1022 DSQVEEDVQ 1030
>sp|P0C6U0|R1A_CVBM Replicase polyprotein 1a OS=Bovine coronavirus
(strain Mebus) OX=11132 GN=1a PE=3 SV=1
Length=4383
Score = 1883 bits (4878), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1099/2898 (38%), Positives = 1629/2898 (56%), Gaps = 141/2898 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LA-CESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMA 2074
++ ++++P +++ ++K +V +VI+ +K + L D+
Sbjct 2025 ISESDAKEPKEINIIKLSGVKKPF--------KVEDSVIVNDDTSEIKYVKSLSIVDVYD 2076
Query 2075 AYVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITT 2130
++ ++ N LS A+ + TI G+ + S+P + L +KP
Sbjct 2077 MWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF------- 2128
Query 2131 SNCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCL 2188
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 -NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVA 2180
Query 2189 DAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVREL 2246
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2181 LAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQW 2240
Query 2247 YLNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK- 2292
N+ ++ T+ +C GS C CL+G D LD+Y A++ +Q
Sbjct 2241 IKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAF 2300
Query 2293 LDLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIV 2349
+D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2301 VDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLA 2360
Query 2350 QMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKR 2409
M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2361 NMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIR 2420
Query 2410 SFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVD 2469
+ ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2421 YYDAMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVT 2480
Query 2470 SVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDES 2529
V + L++D+ GQ+TY+ S FV+ NL + K ++V+V + + D++
Sbjct 2481 DVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKA 2538
Query 2530 ASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKAL 2589
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL
Sbjct 2539 NFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNAL 2598
Query 2590 VATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCN 2648
+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCN
Sbjct 2599 IATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCN 2658
Query 2649 NFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRS 2708
N + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++
Sbjct 2659 NLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKK 2718
Query 2709 AAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI-- 2766
A K + +LT V+V+TT SLKGG + S +C + +LVC+I
Sbjct 2719 ACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGL 2771
Query 2767 --VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SY 2822
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2772 WCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYY 2831
Query 2823 KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEY 2882
N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I Y
Sbjct 2832 SNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISY 2890
Query 2883 SDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQF 2941
S+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+F
Sbjct 2891 SNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRF 2950
Query 2942 PNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAM 3001
P EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2951 PEVLREGLVRIVRTRSMPYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVF 3010
Query 3002 NLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALL 3061
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N ++
Sbjct 3011 DLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIV 3070
Query 3062 FLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIY 3121
+ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y
Sbjct 3071 WCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLY 3130
Query 3122 VFCISLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+ + H W F +Y R+ V +G TFEE AL TF++ K+ Y KL++ L
Sbjct 3131 ISVVVSNHAFWVF-SYCRQLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWL D VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLGDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSV + I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVVYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKH-LKNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIM 3596
+Q +G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T +
Sbjct 3541 QQLAGIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCAL 3598
Query 3597 AIAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYR 3655
+ + MLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3599 CVISLTMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YT 3657
Query 3656 LKDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALV 3714
D V+Y L++ ++ +T R++ + + VI++V Y G+ L++ I + ++
Sbjct 3658 YTDEVIYGMLLLIGMVFVTLRSINQYLFSFIMFVGRVISVVSLWYMGSNLEEEILL--ML 3715
Query 3715 ISVTSNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGL 3773
S+ Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GL
Sbjct 3716 ASLFGTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGL 3773
Query 3774 FCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVA 3833
F L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3774 FSLMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVS 3833
Query 3834 TVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLS 3893
QSK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL
Sbjct 3834 QFQSKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLI 3893
Query 3894 VLLSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN 3947
VL + AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++
Sbjct 3894 VLFANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSS 3953
Query 3948 GDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAM 4006
G + + LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+
Sbjct 3954 GSANQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSAL 4013
Query 4007 QTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTF 4066
QTMLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D
Sbjct 4014 QTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYV 4073
Query 4067 TYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPV 4124
TYA +W+IQ + D+D QL EI+ D + WPL++ A R N SA LQNNEL P
Sbjct 4074 TYAGNVWQIQTIQDSDGTNKQLHEISDDCN----WPLVIIANRHNEVSATALQNNELMPA 4129
Query 4125 ALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYT 4184
L+ +G QT T YYNNS G+ V A+LSD LK+ + K DG +
Sbjct 4130 KLKTQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-L 4186
Query 4185 ELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVL 4244
EL+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++L
Sbjct 4187 ELDPPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSIL 4246
Query 4245 SFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCC 4304
S CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C
Sbjct 4247 SLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVC 4306
Query 4305 LYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
+YCR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4307 IYCRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-T 4364
Query 4365 EPLMQSADASTFLNGFAV 4382
+ +QS D + FLNGF V
Sbjct 4365 DTTVQSKD-TNFLNGFGV 4381
Score = 84.3 bits (207), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 79/155 (51%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 69.3 bits (168), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 57/197 (29%), Positives = 96/197 (49%), Gaps = 18/197 (9%)
Query 822 KGVTFGED-TVWEVQGY-KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEA 879
+ VTF E TV E+ K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A
Sbjct 853 RCVTFKEQPTVNEIASTPKTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDA 912
Query 880 VVKTLQPVSDLL---TNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
+ + L P +L + L + + +LFD+AGEE + ++YC+F P EDD
Sbjct 913 IEEKLSPCKELEGVGAKVSAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDD 968
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEP 995
EE ++E T+ L ++ E V E+EE + L+DT +
Sbjct 969 FLEESGVEEDDVEGEETD-------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETS 1021
Query 996 EPTPEEPVNQFTGYLKL 1012
+ EE V Q + ++ L
Sbjct 1022 DSQVEEDV-QMSDFVDL 1037
>sp|P0C6X6|R1AB_CVHOC Replicase polyprotein 1ab OS=Human coronavirus
OC43 OX=31631 GN=rep PE=1 SV=1
Length=7095
Score = 1883 bits (4877), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1103/2890 (38%), Positives = 1623/2890 (56%), Gaps = 133/2890 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCFKWQVVVNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L + F QEA+ R+G A F AL+LA G+ D R+ + + +L A
Sbjct 1682 SLHLTFKIVQWQEAWLEFRSGRPARFVALVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TG++AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGLDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFIGD-NVGHYVHVKCEQSYQLYDASNVKKVTDVTGKLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E +T +P GDVV + Y ++
Sbjct 1917 DGVYTNFKLIGHTV--CDSLNSKLGFDSSKEFVEYKITEWPTATGDVVLANDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLA 2017
+G KP++W ++ K + T+ R L VD N F+VL V+D + +
Sbjct 1975 RGCITFGKPVIWLSHE---KASLNSLTYFNRPLL----VD-DNKFDVLKVDDVDDSGDSS 2026
Query 2018 CESQQPTSE-EVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAY 2076
+ T E +++ ++K +V +VI+ K + L D+ +
Sbjct 2027 ESGAKETKEINIIKLSGVKKPF--------KVEDSVIVNDDTSETKYVKSLSIVDVYDMW 2078
Query 2077 VENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITTSN 2132
+ ++ N LS A+ + TI G+ + S+P + L +KP A+
Sbjct 2079 LTGCKYVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKP-----AVNVVK 2132
Query 2133 CAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGI 2192
+ FN ++ ++F LLF + + T IA K KL A
Sbjct 2133 AVRNKTSACFN-FIKWLFVLLFGWIKISADN----KVIYTTEIAS---KLTCKLVALAFK 2184
Query 2193 NYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELYLNS 2250
N + K+S + A + + + + I F L G P++ + + N+
Sbjct 2185 NAFLTFKWSMVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQWIKNT 2244
Query 2251 SNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK-LDLT 2296
++ T+ +C GS C CL+G D LD+Y A++ +Q +D T
Sbjct 2245 FSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFVDYT 2304
Query 2297 -ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAP 2353
+L + E +++Y L+T +FY L +Q+ + F+ ++ W ++++ M P
Sbjct 2305 GVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSFRLLVALANMLP 2364
Query 2354 VSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYV 2413
+R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R + V
Sbjct 2365 AHVFMRFYIIIASFIKLFSLFKHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIRYYDV 2424
Query 2414 YANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAV 2473
ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V V
Sbjct 2425 MANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTDVKQ 2484
Query 2474 KNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKS 2533
++ L++D+ GQ+ Y+ S FV+ NL + K ++V+V + + D++ +
Sbjct 2485 VGCSMRLFYDRDGQRIYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKANFLN 2542
Query 2534 ASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATA 2593
A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+ATA
Sbjct 2543 AAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALIATA 2602
Query 2594 HSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFML 2652
HS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN +
Sbjct 2603 HSSIKQGTQIYKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNNLVP 2662
Query 2653 TYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKK 2712
TY K +N+ DLG I +A+H+ VAK VS IW+V + S + +++ A K
Sbjct 2663 TYLKSDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQFSSDFQHKLKKACCK 2722
Query 2713 NNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI----VM 2768
+ +LT V+V+TT SLKGG + S +C + +LVC+I +M
Sbjct 2723 TGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGLWCLM 2775
Query 2769 PVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDK 2826
P +T+ D YK + +GV RD+ D CFANK FD W+ G Y N
Sbjct 2776 PTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSM 2835
Query 2827 SCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFA 2886
+CP+V A+I ++ G V +P VLR LHF+ SA G CYTP I YS+F
Sbjct 2836 ACPIVVAVIDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYSNFY 2894
Query 2887 TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFPNTY 2945
S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+FP
Sbjct 2895 ASGCVLSSACTMFTMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRFPEVL 2954
Query 2946 LEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIA 3005
EG VRVV T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +LI
Sbjct 2955 REGLVRVVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIY 3014
Query 3006 NIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMS 3065
+F L QPV L ++AS +AG I+A++V YY +K +R FG+Y VV N +++ ++
Sbjct 3015 QLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVNVIVWCVN 3074
Query 3066 FTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCI 3125
F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+ +
Sbjct 3075 FMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYIAVV 3134
Query 3126 SLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYN 3182
H W F+ Y RK V +G TFEE AL TF++ K+ Y KL++ L +N
Sbjct 3135 VSNHAFWVFS-YCRKLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSDVAFN 3187
Query 3183 RYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS-GADVLYQPPQTSITSAVLQS 3241
RYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+N+ G+DVLYQPP S++++ LQS
Sbjct 3188 RYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQS 3247
Query 3242 GFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRK 3301
G KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R
Sbjct 3248 GIVKMVNPTSKVEPCVVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRV 3307
Query 3302 SNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
++ F V + L V+ + M+ C+L L V N +TPKY F ++PG+TF+VLA YNG
Sbjct 3308 TSSDFTVLFDRLSLTVMSYQMRGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGK 3367
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD G F
Sbjct 3368 PQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDFNGDF 3427
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YGP+ D Q Q D ++N LAWLYAA++N WF+ ++ DFN+ A+ +
Sbjct 3428 YGPYKDAQVVQLPIQDYIQSVNFLAWLYAAILNNCNWFIQSDKCSVEDFNVWALSNGFSQ 3487
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV +Q +
Sbjct 3488 VKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVYQQLA 3544
Query 3542 GVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
G+ Q K ++ KGT W++ TFL S I+ +W++F +V N F T + + +
Sbjct 3545 GIKLQSKRTRLFKGTVCWIMASTFLFS-CIITAFVKWTMFMYVTTNMF-SITFCALCVIS 3602
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
AMLLVKHKH +L +++ P L T+ Y N +V ++ + WL S+ Y D
Sbjct 3603 LAMLLVKHKHLYLTMYITPVLFTLLYNNYLVVYKHTFRGYVYAWLSYYVPSVE-YTYTDE 3661
Query 3660 VMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
V+Y L++ ++ +T R++ D + + +I++ Y G+ L++ I + ++ S+
Sbjct 3662 VIYGMLLLVGMVFVTLRSINHDLFSFIMFVGRLISVFSLWYKGSNLEEEILL--MLASLF 3719
Query 3719 SNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
Y+ M +A+ I +V V L F ++ ++L Y F+GY CY+GLF L+
Sbjct 3720 GTYTWTTVLSMAVAKVIAKWVAVNV--LYFTDIPQIKIVLLCYLFIGYIISCYWGLFSLM 3777
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QS
Sbjct 3778 NSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQS 3837
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D + AFEK+ LL VL +
Sbjct 3838 KLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVLFA 3897
Query 3898 MQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS- 3950
AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A +G +
Sbjct 3898 NPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARFSGSAN 3957
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ LK+L+K+ N+AKS ++RD A+ +KLE+MAD A+T MYK+AR DK++KV SA+QTML
Sbjct 3958 QQQLKQLEKACNIAKSAYERDRAVAKKLERMADLALTNMYKEARINDKKSKVVSALQTML 4017
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4018 FSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLNIIVPDKSVYDQIVDNIYVTYAG 4077
Query 4071 ALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQ 4128
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4078 NVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRYNEVSATVLQNNELMPAKLKI 4133
Query 4129 MSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEP 4188
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+P
Sbjct 4134 QVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDP 4190
Query 4189 PCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCA 4248
PC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS CA
Sbjct 4191 PCKFTVQDAKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCA 4250
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
F+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+YCR
Sbjct 4251 FSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYCR 4310
Query 4309 CHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLM 4368
++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC + +
Sbjct 4311 ARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCRVCGFWRDGSCSCVS-TDTTV 4368
Query 4369 QSADASTFLN 4378
QS D + FLN
Sbjct 4369 QSKD-TNFLN 4377
Score = 83.6 bits (205), Expect = 6e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 81/155 (52%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ + +K
Sbjct 1273 ITPNVCFVKGDIIKVSKLVKAEVVVNPANGHMVHGGGVAKAIAVAAGQQFVKETTNMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++FN+ D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYVLLERVYKHFNNYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 67.8 bits (164), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 74/284 (26%), Positives = 126/284 (44%), Gaps = 26/284 (9%)
Query 729 LLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVC- 784
L MP KA ++ +L+G D L V + L TP ++ V +C
Sbjct 763 LTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSL----TPC-GYSEPPKVADKICI 817
Query 785 VNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY-KNVRI 842
V+ + + + DK + + + +R+ + VTF E TV E+ K +++
Sbjct 818 VDNVYMAKAGDKYYPVVVDDHVGLLDQAWRVPCAG--RRVTFKEQPTVKEIISMPKIIKV 875
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLL---TNMGIDLD 899
+ELD + +LN C V+ V+ ++ EF VV +A+ + L P +L + L
Sbjct 876 FYELDNDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKVSAFLQ 935
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ +LFD+AGEE F+ ++YC+F P E+DD ++E+ E E +
Sbjct 936 KLEDNPLFLFDEAGEEVFAPKLYCAFTAP---EDDDF------LEESDVEEDDVEGEETD 986
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV 1003
L + A V E+EE + L+DT + + EE V
Sbjct 987 LTIT-SAGQPCVASEQEESSEVLEDTLDDGPSVETSDSQVEEDV 1029
>sp|P0C6X0|R1AB_CVBQ Replicase polyprotein 1ab OS=Bovine coronavirus
(strain Quebec) OX=11133 GN=rep PE=3 SV=1
Length=7059
Score = 1879 bits (4867), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1097/2894 (38%), Positives = 1625/2894 (56%), Gaps = 141/2894 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LA-CESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMA 2074
++ ++++P +++ ++K +V +VI+ +K + L D+
Sbjct 2025 ISESDAKEPKEINIIKLSGVKKPF--------KVEDSVIVNDDTSEIKYVKSLSIVDVYD 2076
Query 2075 AYVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITT 2130
++ ++ N LS A+ + TI G+ + S+P + L +KP
Sbjct 2077 MWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF------- 2128
Query 2131 SNCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCL 2188
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 -NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVA 2180
Query 2189 DAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVREL 2246
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2181 LAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIVQW 2240
Query 2247 YLNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK- 2292
N+ ++ T+ +C GS C CL+G D LD+Y A++ +Q
Sbjct 2241 IKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAF 2300
Query 2293 LDLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIV 2349
+D T +L + E +++Y L+T +FY L +Q+ + + ++ W + ++S+
Sbjct 2301 VDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELLMLSTLHWSVRLLVSLA 2360
Query 2350 QMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKR 2409
M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2361 NMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIR 2420
Query 2410 SFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVD 2469
+ V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2421 YYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVT 2480
Query 2470 SVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDES 2529
V + L++D+ GQ+TY+ S FV+ NL + K ++V+V + + D++
Sbjct 2481 DVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKA 2538
Query 2530 ASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKAL 2589
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL
Sbjct 2539 NFLNAAVFYAQSLFRPILMVDKILITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNAL 2598
Query 2590 VATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCN 2648
+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCN
Sbjct 2599 IATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCN 2658
Query 2649 NFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRS 2708
N + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++
Sbjct 2659 NLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKK 2718
Query 2709 AAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI-- 2766
A K + LT V+V+TT SLKGG + S +C + +LVC+I
Sbjct 2719 ACCKTGLKLELTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGL 2771
Query 2767 --VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SY 2822
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2772 WCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYY 2831
Query 2823 KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEY 2882
N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I Y
Sbjct 2832 SNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISY 2890
Query 2883 SDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQF 2941
S+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+
Sbjct 2891 SNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRL 2950
Query 2942 PNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAM 3001
P EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2951 PEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVF 3010
Query 3002 NLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALL 3061
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N ++
Sbjct 3011 DLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLGFYYLIKLKRAFGDYTSIVFVNVIV 3070
Query 3062 FLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIY 3121
+ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y
Sbjct 3071 WCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLY 3130
Query 3122 VFCISLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+ + H W F+ Y R+ V +G TFEE AL TF++ K+ Y KL++ L
Sbjct 3131 ISVVVSNHAFWVFS-YCRQLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS-GADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+N+ G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKR-LKNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIM 3596
+Q +G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T +
Sbjct 3541 QQLAGIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCAL 3598
Query 3597 AIAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYR 3655
+ + AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3599 CVISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YT 3657
Query 3656 LKDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALV 3714
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++
Sbjct 3658 YTDEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--ML 3715
Query 3715 ISVTSNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGL 3773
S+ Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GL
Sbjct 3716 ASLFGTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGL 3773
Query 3774 FCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVA 3833
F L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3774 FSLMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVS 3833
Query 3834 TVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLS 3893
QSK++DVKC + LL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL
Sbjct 3834 QFQSKLTDVKCANGGLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLI 3893
Query 3894 VLLSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN 3947
VL + AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++
Sbjct 3894 VLFANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSS 3953
Query 3948 GDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAM 4006
G + + LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+
Sbjct 3954 GSANQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSAL 4013
Query 4007 QTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTF 4066
QTMLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D
Sbjct 4014 QTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYV 4073
Query 4067 TYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPV 4124
TYA +W+IQ + D+D QL EI S + WPL++ A R N SA LQNNEL P
Sbjct 4074 TYAGNVWQIQTIQDSDGTNKQLHEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPA 4129
Query 4125 ALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYT 4184
L+ +G QT T YYNNS G+ V A+LSD LK+ + K DG +
Sbjct 4130 KLKTQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-L 4186
Query 4185 ELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVL 4244
EL+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++L
Sbjct 4187 ELDPPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSIL 4246
Query 4245 SFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCC 4304
S CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C
Sbjct 4247 SLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVC 4306
Query 4305 LYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
+YCR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4307 IYCRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-T 4364
Query 4365 EPLMQSADASTFLN 4378
+ +QS D + FLN
Sbjct 4365 DTTVQSKD-TNFLN 4377
Score = 84.7 bits (208), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 79/155 (51%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 66.2 bits (160), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 54/188 (29%), Positives = 90/188 (48%), Gaps = 17/188 (9%)
Query 822 KGVTFGED-TVWEVQGY-KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEA 879
+ VTF E TV E+ K +++ +ELD+ + +LN C + V+ ++ EF VV +A
Sbjct 853 RCVTFKEQPTVNEIASTPKTIKVFYELDKDFNTILNTACGEFEVDDTVDMEEFYAVVIDA 912
Query 880 VVKTLQPVSDLL---TNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
+ + L P +L + L + + +LFD+AGEE + ++YC+F P EDD
Sbjct 913 IEEKLSPCKELEGVGAKVSAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDD 968
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEP 995
EE ++E T+ L ++ E V E+EE + L+DT +
Sbjct 969 FLEESGVEEDDVEGEETD-------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETS 1021
Query 996 EPTPEEPV 1003
+ EE V
Sbjct 1022 DSQVEEDV 1029
>sp|P0C6W9|R1AB_CVBM Replicase polyprotein 1ab OS=Bovine coronavirus
(strain Mebus) OX=11132 GN=rep PE=3 SV=1
Length=7094
Score = 1876 bits (4860), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1096/2894 (38%), Positives = 1625/2894 (56%), Gaps = 141/2894 (5%)
Query 1545 IKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTL 1604
+ + TVD N + V + ++G+ G + DG +VTK K +N++GK FF D L
Sbjct 1565 VDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQF---DNL 1621
Query 1605 RSE---AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
SE A D+ L Y + L + KW+ G + K A+NNC+++ L LQ
Sbjct 1622 SSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQ 1681
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
L +KF QEA+ R+G A F +L+LA G+ D R+ + + +L A
Sbjct 1682 SLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGA 1741
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
+ CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F
Sbjct 1742 ICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPF 1799
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++
Sbjct 1800 LICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLS 1857
Query 1842 DVFYKETSYTTTIKPV--SYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLP 1898
D Y + + T K V +Y LD V E +P L YY YYT++ I T
Sbjct 1858 DCLYLK-NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKV 1916
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL D LN GF + E VT +P GDVV Y ++
Sbjct 1917 DGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYE 1974
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP--VDTSNSFEVLAVEDTQGMDN 2015
+G KP++W ++ + + + +P VD N F+VL V+D +
Sbjct 1975 RGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVD-ENKFDVLKVDDVDDGGD 2024
Query 2016 LA-CESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMA 2074
++ ++++P +++ ++K +V +VI+ +K + L D+
Sbjct 2025 ISESDAKEPKEINIIKLSGVKKPF--------KVEDSVIVNDDTSEIKYVKSLSIVDVYD 2076
Query 2075 AYVENTSITIKKPNELSLALGLKTI---ATHGIAAINSVPWSKI-LAYVKPFLGQAAITT 2130
++ ++ N LS A+ + TI G+ + S+P + L +KP
Sbjct 2077 MWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLV-SIPIDLLNLREIKPVF------- 2128
Query 2131 SNCAKRLAQRVFN--NYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCL 2188
N K + ++ N++ ++F LLF + + T +A K KL
Sbjct 2129 -NVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVA 2180
Query 2189 DAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVREL 2246
A N + K+S + A + + + + I F L G P++ + +
Sbjct 2181 LAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIAQW 2240
Query 2247 YLNSSNVTTM-------------DFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK- 2292
N+ ++ T+ +C GS C CL+G D LD+Y A++ +Q
Sbjct 2241 IKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAF 2300
Query 2293 LDLT-ILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIV 2349
+D T +L + E +++Y L+T +FY L +Q+ + F+ ++ W + ++S+
Sbjct 2301 VDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVRLLVSLA 2360
Query 2350 QMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKR 2409
M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R
Sbjct 2361 NMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIR 2420
Query 2410 SFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVD 2469
+ ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V
Sbjct 2421 YYDAMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVT 2480
Query 2470 SVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDES 2529
V + L++D+ GQ+TY+ S FV+ NL + K ++V+V + + D++
Sbjct 2481 DVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKA 2538
Query 2530 ASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKAL 2589
+A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V + L AL
Sbjct 2539 NFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNAL 2598
Query 2590 VATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCN 2648
+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCN
Sbjct 2599 IATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCN 2658
Query 2649 NFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRS 2708
N + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS + +++
Sbjct 2659 NLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKK 2718
Query 2709 AAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYI-- 2766
A K + +LT V+V+TT SLKGG + S +C + +LVC+I
Sbjct 2719 ACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSY-------FVYVCFVLSLVCFIGL 2771
Query 2767 --VMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SY 2822
+MP +T+ D YK + +GV RD+ D CFANK FD W+ G Y
Sbjct 2772 WCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYY 2831
Query 2823 KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEY 2882
N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I Y
Sbjct 2832 SNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISY 2890
Query 2883 SDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQF 2941
S+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I+F
Sbjct 2891 SNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRF 2950
Query 2942 PNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAM 3001
P EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2951 PEVLREGLVRIVRTRSMPYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVF 3010
Query 3002 NLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALL 3061
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N ++
Sbjct 3011 DLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNVIV 3070
Query 3062 FLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIY 3121
+ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W +Y
Sbjct 3071 WCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLY 3130
Query 3122 VFCISLKHCHWFFNNYLRK---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+ + H W F +Y R+ V +G TFEE AL TF++ K+ Y KL++ L
Sbjct 3131 ISVVVSNHAFWVF-SYCRQLGTSVRSDG----TFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F+ N+G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWL D VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLGDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSV + I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVVYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L+NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKH-LKNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIM 3596
+Q +G+ Q K ++VKG W++ TFL S I+ +W++F +V N L T +
Sbjct 3541 QQLAGIKLQSKRTRLVKGIVCWIMASTFLFS-CIITAFVKWTMFMYVTTN-MLSITFCAL 3598
Query 3597 AIAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYR 3655
+ + MLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3599 CVISLTMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YT 3657
Query 3656 LKDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALV 3714
D V+Y L++ ++ +T R++ + + VI++V Y G+ L++ I + ++
Sbjct 3658 YTDEVIYGMLLLIGMVFVTLRSINQYLFSFIMFVGRVISVVSLWYMGSNLEEEILL--ML 3715
Query 3715 ISVTSNYSGVVTTIMFLARAIV-FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGL 3773
S+ Y+ M A+ I +V V L F ++ +++ Y F+GY CY+GL
Sbjct 3716 ASLFGTYTWTTALSMAAAKVIAKWVAVNV--LYFTDIPQIKIVLVCYLFIGYIISCYWGL 3773
Query 3774 FCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVA 3833
F L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3774 FSLMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVS 3833
Query 3834 TVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLS 3893
QSK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL
Sbjct 3834 QFQSKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLI 3893
Query 3894 VLLSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN 3947
VL + AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++
Sbjct 3894 VLFANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSS 3953
Query 3948 GDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAM 4006
G + + LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+
Sbjct 3954 GSANQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSAL 4013
Query 4007 QTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTF 4066
QTMLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D
Sbjct 4014 QTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYV 4073
Query 4067 TYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPV 4124
TYA +W+IQ + D+D QL EI S + WPL++ A R N SA LQNNEL P
Sbjct 4074 TYAGNVWQIQTIQDSDGTNKQLHEI----SDDCNWPLVIIANRHNEVSATALQNNELMPA 4129
Query 4125 ALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYT 4184
L+ +G QT T YYNNS G+ V A+LSD LK+ + K DG +
Sbjct 4130 KLKTQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-L 4186
Query 4185 ELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVL 4244
EL+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++L
Sbjct 4187 ELDPPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSIL 4246
Query 4245 SFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCC 4304
S CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C
Sbjct 4247 SLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVC 4306
Query 4305 LYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
+YCR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4307 IYCRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVS-T 4364
Query 4365 EPLMQSADASTFLN 4378
+ +QS D + FLN
Sbjct 4365 DTTVQSKD-TNFLN 4377
Score = 84.3 bits (207), Expect = 3e-14, Method: Compositional matrix adjust.
Identities = 51/155 (33%), Positives = 79/155 (51%), Gaps = 2/155 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1273 ITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVKS 1332
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPN--LNAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+SA
Sbjct 1333 KGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISA 1392
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GIF SL + T + QV + N++ ++ +
Sbjct 1393 GIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 69.3 bits (168), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 57/197 (29%), Positives = 96/197 (49%), Gaps = 18/197 (9%)
Query 822 KGVTFGED-TVWEVQGY-KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEA 879
+ VTF E TV E+ K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A
Sbjct 853 RCVTFKEQPTVNEIASTPKTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDA 912
Query 880 VVKTLQPVSDLL---TNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
+ + L P +L + L + + +LFD+AGEE + ++YC+F P EDD
Sbjct 913 IEEKLSPCKELEGVGAKVSAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDD 968
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEP 995
EE ++E T+ L ++ E V E+EE + L+DT +
Sbjct 969 FLEESGVEEDDVEGEETD-------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETS 1021
Query 996 EPTPEEPVNQFTGYLKL 1012
+ EE V Q + ++ L
Sbjct 1022 DSQVEEDV-QMSDFVDL 1037
>sp|P0C6U9|R1A_CVM2 Replicase polyprotein 1a OS=Murine coronavirus
(strain 2) OX=76344 GN=1a PE=3 SV=1
Length=4416
Score = 1869 bits (4841), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1107/2938 (38%), Positives = 1618/2938 (55%), Gaps = 147/2938 (5%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+V S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1543 KVASVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1598
Query 1586 PHVNHEGKTFF----VLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGL 1641
H+GK FF + +D ++AF + DE L +Y + L K W G
Sbjct 1599 CSAIHKGKVFFQYSGLSAADLVAVTDAFGF----DEPQLLKYYNMLGMCK-WPVVVCGNY 1653
Query 1642 TSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGE 1701
+ K ++NNCY++ L LQ L +KF+ QEA+ R+G F +L+LA + E
Sbjct 1654 FAFKQSNNNCYINVACLMLQHLSLKFHKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNE 1713
Query 1702 LGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVS 1761
D + M +L+ A+L A VCK CG K GV+AVM+ GTL +L G +
Sbjct 1714 PSDSTDFMRVVLREADLSGATCDFEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLAKGYT 1772
Query 1762 IPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKET 1821
I C CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1773 IACTCGNKLV-HCTQLNVPFLICSNKPEGKKLPDDV-VAANIFTGG-SLGHYTHVKCKPK 1829
Query 1822 LYRIDGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKD 1880
D +++K+SE KG TD Y K T + K ++ LD V E P L YY +
Sbjct 1830 YQLYDACNVSKVSEAKGNFTDCLYLKNLKQTFSSKLTTFYLDDVKCVEYNPDLSQYYCES 1889
Query 1881 NAYYTEQPIDLVPTQPLPNAS--FDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFF 1937
YYT +PI + + NFKL A+ N GF E +T +
Sbjct 1890 GKYYT-KPIIKAQFRTFEKVEGVYTNFKLV--GHSIAEKFNAKLGFDCNSPFTEYKITEW 1946
Query 1938 PDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWCLRCLWST 1993
P GDVV Y + + G KP++W H + T+ +P+ C ++
Sbjct 1947 PTATGDVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVCEN-KFNV 2005
Query 1994 KPVDTSNSFEV----LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE--------- 2040
PVD S + AV T + A ++V + ++ +V+
Sbjct 2006 LPVDVSEPTDKGPVPAAVLVTGALSGAATAPGTAKEQKVCASDSVVDQVVSGFLSDLSGA 2065
Query 2041 -CDVKTTEVVG---------NVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNEL 2090
DVK ++ G +V++ KV + L D+ ++ + NEL
Sbjct 2066 TVDVKEVKLNGVKKPIKVEDSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWMANEL 2125
Query 2091 SLALGLKTIATHGIAAINSVPW--SKILAYVKPFLGQAAITTSNCAKRLAQRVFNNY--M 2146
S + T+ + V W +KI+ K L + K + +V Y +
Sbjct 2126 SRLVNSPTVREY-------VKWGMTKIVIPAKLVLLRDEKQEFVAPKVVKAKVIACYSAV 2178
Query 2147 PYVFTLLFQLCTF--------TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSP 2198
+ F F F T S++ +L KN++++ + G V +
Sbjct 2179 KWFFLYCFSWIKFNTDNKVIYTTEVASKLTFNLCCLAFKNALQTFNWNVVSRGFFLVAT- 2237
Query 2199 KFSKLFTIAMWLLLLSICLGSLICVTAAF---------GVLLSNFGAPSYCNGVRELYLN 2249
+F + L ++ L F + + FG + C +LY
Sbjct 2238 ----VFLLWFNFLYANVILSDFYLPNIGFFPTFVGQIVAWVKTTFGIFTLC----DLYQV 2289
Query 2250 SSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEWVLA 2307
S FC GS C +C SG D LD+Y A+ +Q V D +++ L E V+
Sbjct 2290 SDVGYRSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRVSFDYISLFKLVVELVIG 2349
Query 2308 YMLFTKFFY-LLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFF 2364
Y L+T FY L GL MQ+ + F+ + W F + + M P ++R YI
Sbjct 2350 YSLYTVCFYPLFGLIG-MQLLTTWLPEFFMLETMHWSARFFVFVANMLPAFTLLRFYIVV 2408
Query 2365 ASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKT 2424
+ Y I+ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC
Sbjct 2409 TAMYKIFCLCRHVMYGCSRPGCLFCYKRNRSVRVKCSTVVGGTLRYYDVMANGGTGFCAK 2468
Query 2425 HNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDK 2484
H WNCLNC F G+TFI+ E A DLS + KRP+NPTD + Y+V V ++ L++++
Sbjct 2469 HQWNCLNCSAFGPGNTFITHEAAADLSKELKRPVNPTDSAYYLVTEVKQVGCSMRLFYER 2528
Query 2485 AGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQ 2544
GQ+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +
Sbjct 2529 DGQRVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYR 2586
Query 2545 PILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALD 2604
P+LL+++ L++ VS MFD YVD+ V + L + V AH+ L +GV L+
Sbjct 2587 PMLLVEKKLITTANTGLSVSQTMFDLYVDSLLGVLDVDRKSLTSFVNAAHNSLKEGVQLE 2646
Query 2605 GVLSTFVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPR 2663
V+ TF+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + +
Sbjct 2647 QVMDTFIGCARRKCAIDSDVETKSITKSIMSAVNAGVDFTDESCNNLVPTYVKSDTIVAA 2706
Query 2664 DLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCAT 2723
DLG I NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2707 DLGVLIQNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNK 2766
Query 2724 TRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEI 2783
V ++TT SLKGG + S + + L+C + V + +MP + + D
Sbjct 2767 QEANVPILTTPFSLKGGAVFSKVLQWLFVVNLICFI---VLWALMPTYAVHKSDMQLPLY 2823
Query 2784 IGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGF 2841
+K I +GV RD+ TD CFANK FD W+ G Y+N ++CPVV A+I ++IG+
Sbjct 2824 ASFKVIDNGVLRDVTVTDACFANKFIQFDQWYESTFGLVYYRNSRACPVVVAVIDQDIGY 2883
Query 2842 IVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKD 2901
+ +P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+
Sbjct 2884 TLFNVPTKVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAH 2942
Query 2902 AMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEY 2960
A G P PYCY ++ + Y L P RY L + + I+FP EG VR+V T Y
Sbjct 2943 ADGTPHPYCYTEGIMHNASLYDSLAPHVRYNLANSNGYIRFPEVVSEGIVRIVRTRSMTY 3002
Query 2961 CRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDV 3020
CR G CE +E G+C + + WVLNN +YRA+ G FCG +A +LI + LV+P+ +
Sbjct 3003 CRVGLCEDAEEGVCFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFAL 3062
Query 3021 SASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPG 3080
+AS VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L
Sbjct 3063 TASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSC 3122
Query 3081 VYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRK 3140
+Y+ FY Y T YF +++S + HLQW M+ I+P W IYV + H W F+ Y RK
Sbjct 3123 LYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFS-YCRK 3181
Query 3141 ---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
V +G TFEE +L TF++ KE Y KL++ + +NRYL+LYNKY+YFSG
Sbjct 3182 LGTEVRSDG----TFEEMSLTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGK 3235
Query 3198 LDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGC 3256
+DT +YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM FP+ KVE C
Sbjct 3236 MDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVFPTSKVEPC 3295
Query 3257 MVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLR 3316
+V VT G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R + F V +G + L
Sbjct 3296 VVSVTYGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYSNLLCRVISSDFCVMSGRMSLT 3355
Query 3317 VIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTI 3376
V+ + MQ LL L V NP TPKY F ++PG+TF+VLA YNG G + MR ++TI
Sbjct 3356 VMSYQMQGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGKSQGAFHVTMRSSYTI 3415
Query 3377 KGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
KGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q
Sbjct 3416 KGSFLCGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQ 3475
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
D T T+NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++
Sbjct 3476 DYTQTVNVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASM 3533
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGT 3556
TG+ V + AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K ++VKGT
Sbjct 3534 TGVTVEQILAAIKRLY-SGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVVKGT 3592
Query 3557 HHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLF 3616
W+L + L I+ +W++F +V + L TL + + AMLLVKHKH +L +F
Sbjct 3593 CCWILASTLLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLVKHKHLYLTMF 3651
Query 3617 LLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASA-LVLLILMTA 3674
++P L T+ Y N +V S+ WL ++ Y D V+Y LV ++ +T
Sbjct 3652 IMPVLCTLFYTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTM 3710
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R++ D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A
Sbjct 3711 RSINHDVFSVMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATA 3766
Query 3735 IVFVCVEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
V +L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S
Sbjct 3767 KVIAKWLAVNVLYFTDVPQVKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKIS 3826
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
QE RYMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ L
Sbjct 3827 VQELRYMNANGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQSRLTDVKCVNVVLLNCL 3886
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRL 3907
Q L + SSSKLW C LHN+IL D + AF+K+ LL VL + AVD I +
Sbjct 3887 QHLHIASSSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEV 3946
Query 3908 CEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKS 3966
++ + + LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS
Sbjct 3947 SDDYVRDSTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKS 4006
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I+
Sbjct 4007 AYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMIRKLDNQALNSIL 4066
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+NA GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD +
Sbjct 4067 DNAVKGCVPLNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQSIQDADGAVK 4126
Query 4087 QLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDN 4144
QL+EI++ N+ WPL++ A R N S+V LQNNEL P LR +G+ T
Sbjct 4127 QLNEIDV----NITWPLVIAANRHNEVSSVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ 4182
Query 4145 ALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKY 4204
YYN + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KY
Sbjct 4183 --CYYNTTGMGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKY 4239
Query 4205 LYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASG 4264
LYF+KG N L RG V+G+L++TVRLQAG ATE +NS + S CAF+VDP K Y DY+ G
Sbjct 4240 LYFVKGCNTLARGWVVGTLSSTVRLQAGTATEYASNSAIRSLCAFSVDPKKTYLDYIQQG 4299
Query 4265 GQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKG 4324
G P+TNCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+G
Sbjct 4300 GAPVTNCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRG 4359
Query 4325 KYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
K+VQ+P DPV + L + VC VCG W+ CSC QS D + FLNGF V
Sbjct 4360 KFVQVPLG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQF-QSKD-TNFLNGFGV 4414
Score = 76.3 bits (186), Expect = 8e-12, Method: Compositional matrix adjust.
Identities = 113/464 (24%), Positives = 193/464 (42%), Gaps = 57/464 (12%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT- 620
+LDG+ +S L+ + MV S +T+ + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMALLFMHDVKVATKYVKKVTGKLA 635
Query 621 -------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
V +R I EW + + W + L+ G+F + G I SD + +
Sbjct 636 VRFKALGVAVVRKITEWFDLAVDTAAS--AAGWLCYQ-LVNGLFAVANGGITFLSD-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A K +Y + K +
Sbjct 692 LVKNFVDKFKVFFKVLIDSMSVSVLSGLTVVKTASNRVCLAGCK-VYE--VVQKRLSAYV 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V+ + V + L + P SF +V + L
Sbjct 749 MPVGC-NEATCLVGEIEPAVVEDDVVDVVKAPLTYQGCCKPPTSFEKICVV------DKL 801
Query 789 MLLEIKDKEQYCAL---SPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITF 844
+ + D+ + + G+L F G K V F + V E+ + ++I F
Sbjct 802 YMAKCGDQFYPVVVDNDTIGVLDQCWRFPCAG----KKVEFNDKPKVKEIPSTRKIKINF 857
Query 845 ELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEW 901
LD D VL++ CS + V+ + E VV +AV TL P + + T + L+
Sbjct 858 ALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHDVIGTKVCALLNRL 917
Query 902 SVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLP 961
+ YLFD+ GEE + +MYCSF PD+E +C ++ + E++ DD L
Sbjct 918 AEDYVYLFDEGGEEVIAPKMYCSFSAPDDE-----DCVAADVVDADENQGDDADDSAALV 972
Query 962 L----EFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEE 1001
E G + V V E + D E +IE +P E
Sbjct 973 TDTQEEDGVAKGQVGVAESDAR---LDQVEAFDIEKVEDPILNE 1013
Score = 57.4 bits (137), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 52/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + VIVN AN + HG GVAGA+ KA + KE+ D +K
Sbjct 1267 ITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKSFIKETADMVKN 1326
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VG +G NL K L++VGP+ + + L+ AY++ N D ++ L+SA
Sbjct 1327 QGVCQVGECYESTGGNLCKTVLNIVGPDARGHGKQCYSFLERAYQHINKCDDVVTTLISA 1386
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N+K
Sbjct 1387 GIFSVPTDVSLTYLIGVVTKNVILVSNNK 1415
>sp|P0C6X8|R1AB_CVM2 Replicase polyprotein 1ab OS=Murine coronavirus
(strain 2) OX=76344 GN=rep PE=3 SV=1
Length=7124
Score = 1864 bits (4828), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1098/2916 (38%), Positives = 1608/2916 (55%), Gaps = 145/2916 (5%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+V S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1543 KVASVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1598
Query 1586 PHVNHEGKTFF----VLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGL 1641
H+GK FF + +D ++AF + DE L +Y + L K W G
Sbjct 1599 CSAIHKGKVFFQYSGLSAADLVAVTDAFGF----DEPQLLKYYNMLGMCK-WPVVVCGNY 1653
Query 1642 TSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGE 1701
+ K ++NNCY++ L LQ L +KF+ QEA+ R+G F +L+LA + E
Sbjct 1654 FAFKQSNNNCYINVACLMLQHLSLKFHKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNE 1713
Query 1702 LGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVS 1761
D + M +L+ A+L A VCK CG K GV+AVM+ GTL +L G +
Sbjct 1714 PSDSTDFMRVVLREADLSGATCDFEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLAKGYT 1772
Query 1762 IPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKET 1821
I C CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1773 IACTCGNKLV-HCTQLNVPFLICSNKPEGKKLPDDV-VAANIFTGG-SLGHYTHVKCKPK 1829
Query 1822 LYRIDGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKD 1880
D +++K+SE KG TD Y K T + K ++ LD V E P L YY +
Sbjct 1830 YQLYDACNVSKVSEAKGNFTDCLYLKNLKQTFSSKLTTFYLDDVKCVEYNPDLSQYYCES 1889
Query 1881 NAYYTEQPIDLVPTQPLPNAS--FDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFF 1937
YYT +PI + + NFKL A+ N GF E +T +
Sbjct 1890 GKYYT-KPIIKAQFRTFEKVEGVYTNFKLV--GHSIAEKFNAKLGFDCNSPFTEYKITEW 1946
Query 1938 PDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWCLRCLWST 1993
P GDVV Y + + G KP++W H + T+ +P+ C ++
Sbjct 1947 PTATGDVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVCEN-KFNV 2005
Query 1994 KPVDTSNSFEV----LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE--------- 2040
PVD S + AV T + A ++V + ++ +V+
Sbjct 2006 LPVDVSEPTDKGPVPAAVLVTGALSGAATAPGTAKEQKVCASDSVVDQVVSGFLSDLSGA 2065
Query 2041 -CDVKTTEVVG---------NVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNEL 2090
DVK ++ G +V++ KV + L D+ ++ + NEL
Sbjct 2066 TVDVKEVKLNGVKKPIKVEDSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWMANEL 2125
Query 2091 SLALGLKTIATHGIAAINSVPW--SKILAYVKPFLGQAAITTSNCAKRLAQRVFNNY--M 2146
S + T+ + V W +KI+ K L + K + +V Y +
Sbjct 2126 SRLVNSPTVREY-------VKWGMTKIVIPAKLVLLRDEKQEFVAPKVVKAKVIACYSAV 2178
Query 2147 PYVFTLLFQLCTF--------TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSP 2198
+ F F F T S++ +L KN++++ + G V +
Sbjct 2179 KWFFLYCFSWIKFNTDNKVIYTTEVASKLTFNLCCLAFKNALQTFNWNVVSRGFFLVAT- 2237
Query 2199 KFSKLFTIAMWLLLLSICLGSLICVTAAF---------GVLLSNFGAPSYCNGVRELYLN 2249
+F + L ++ L F + + FG + C +LY
Sbjct 2238 ----VFLLWFNFLYANVILSDFYLPNIGFFPTFVGQIVAWVKTTFGIFTLC----DLYQV 2289
Query 2250 SSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEWVLA 2307
S FC GS C +C SG D LD+Y A+ +Q V D +++ L E V+
Sbjct 2290 SDVGYRSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRVSFDYISLFKLVVELVIG 2349
Query 2308 YMLFTKFFY-LLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFF 2364
Y L+T FY L GL MQ+ + F+ + W F + + M P ++R YI
Sbjct 2350 YSLYTVCFYPLFGLIG-MQLLTTWLPEFFMLETMHWSARFFVFVANMLPAFTLLRFYIVV 2408
Query 2365 ASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKT 2424
+ Y I+ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC
Sbjct 2409 TAMYKIFCLCRHVMYGCSRPGCLFCYKRNRSVRVKCSTVVGGTLRYYDVMANGGTGFCAK 2468
Query 2425 HNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDK 2484
H WNCLNC F G+TFI+ E A DLS + KRP+NPTD + Y+V V ++ L++++
Sbjct 2469 HQWNCLNCSAFGPGNTFITHEAAADLSKELKRPVNPTDSAYYLVTEVKQVGCSMRLFYER 2528
Query 2485 AGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQ 2544
GQ+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +
Sbjct 2529 DGQRVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYR 2586
Query 2545 PILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALD 2604
P+LL+++ L++ VS MFD YVD+ V + L + V AH+ L +GV L+
Sbjct 2587 PMLLVEKKLITTANTGLSVSQTMFDLYVDSLLGVLDVDRKSLTSFVNAAHNSLKEGVQLE 2646
Query 2605 GVLSTFVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPR 2663
V+ TF+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + +
Sbjct 2647 QVMDTFIGCARRKCAIDSDVETKSITKSIMSAVNAGVDFTDESCNNLVPTYVKSDTIVAA 2706
Query 2664 DLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCAT 2723
DLG I NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2707 DLGVLIQNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNK 2766
Query 2724 TRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEI 2783
V ++TT SLKGG + S + + L+C + V + +MP + + D
Sbjct 2767 QEANVPILTTPFSLKGGAVFSKVLQWLFVVNLICFI---VLWALMPTYAVHKSDMQLPLY 2823
Query 2784 IGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGF 2841
+K I +GV RD+ TD CFANK FD W+ G Y+N ++CPVV A+I ++IG+
Sbjct 2824 ASFKVIDNGVLRDVTVTDACFANKFIQFDQWYESTFGLVYYRNSRACPVVVAVIDQDIGY 2883
Query 2842 IVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKD 2901
+ +P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+
Sbjct 2884 TLFNVPTKVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAH 2942
Query 2902 AMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEY 2960
A G P PYCY ++ + Y L P RY L + + I+FP EG VR+V T Y
Sbjct 2943 ADGTPHPYCYTEGIMHNASLYDSLAPHVRYNLANSNGYIRFPEVVSEGIVRIVRTRSMTY 3002
Query 2961 CRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDV 3020
CR G CE +E G+C + + WVLNN +YRA+ G FCG +A +LI + LV+P+ +
Sbjct 3003 CRVGLCEDAEEGVCFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFAL 3062
Query 3021 SASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPG 3080
+AS VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L
Sbjct 3063 TASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSC 3122
Query 3081 VYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRK 3140
+Y+ FY Y T YF +++S + HLQW M+ I+P W IYV + H W F+ Y RK
Sbjct 3123 LYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFS-YCRK 3181
Query 3141 ---RVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
V +G TFEE +L TF++ KE Y KL++ + +NRYL+LYNKY+YFSG
Sbjct 3182 LGTEVRSDG----TFEEMSLTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGK 3235
Query 3198 LDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGC 3256
+DT +YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM FP+ KVE C
Sbjct 3236 MDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVFPTSKVEPC 3295
Query 3257 MVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLR 3316
+V VT G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R + F V +G + L
Sbjct 3296 VVSVTYGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYSNLLCRVISSDFCVMSGRMSLT 3355
Query 3317 VIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTI 3376
V+ + MQ LL L V NP TPKY F ++PG+TF+VLA YNG G + MR ++TI
Sbjct 3356 VMSYQMQGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGKSQGAFHVTMRSSYTI 3415
Query 3377 KGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
KGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q
Sbjct 3416 KGSFLCGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQ 3475
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
D T T+NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++
Sbjct 3476 DYTQTVNVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASM 3533
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGT 3556
TG+ V + AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K ++VKGT
Sbjct 3534 TGVTVEQILAAIKRLY-SGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVVKGT 3592
Query 3557 HHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLF 3616
W+L + L I+ +W++F +V + L TL + + AMLLVKHKH +L +F
Sbjct 3593 CCWILASTLLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLVKHKHLYLTMF 3651
Query 3617 LLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASA-LVLLILMTA 3674
++P L T+ Y N +V S+ WL ++ Y D V+Y LV ++ +T
Sbjct 3652 IMPVLCTLFYTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTM 3710
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R++ D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A
Sbjct 3711 RSINHDVFSVMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATA 3766
Query 3735 IVFVCVEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
V +L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S
Sbjct 3767 KVIAKWLAVNVLYFTDVPQVKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKIS 3826
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
QE RYMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ L
Sbjct 3827 VQELRYMNANGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQSRLTDVKCVNVVLLNCL 3886
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRL 3907
Q L + SSSKLW C LHN+IL D + AF+K+ LL VL + AVD I +
Sbjct 3887 QHLHIASSSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEV 3946
Query 3908 CEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKS 3966
++ + + LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS
Sbjct 3947 SDDYVRDSTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKS 4006
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I+
Sbjct 4007 AYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMIRKLDNQALNSIL 4066
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+NA GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD +
Sbjct 4067 DNAVKGCVPLNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQSIQDADGAVK 4126
Query 4087 QLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDN 4144
QL+EI++ N+ WPL++ A R N S+V LQNNEL P LR +G+ T
Sbjct 4127 QLNEIDV----NITWPLVIAANRHNEVSSVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ 4182
Query 4145 ALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKY 4204
YYN + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KY
Sbjct 4183 --CYYNTTGMGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKY 4239
Query 4205 LYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASG 4264
LYF+KG N L RG V+G+L++TVRLQAG ATE +NS + S CAF+VDP K Y DY+ G
Sbjct 4240 LYFVKGCNTLARGWVVGTLSSTVRLQAGTATEYASNSAIRSLCAFSVDPKKTYLDYIQQG 4299
Query 4265 GQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKG 4324
G P+TNCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+G
Sbjct 4300 GAPVTNCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRG 4359
Query 4325 KYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
K+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4360 KFVQVPLG-IKDPVSYVLTHDVCQVCGFWRDGSCSC 4394
Score = 76.6 bits (187), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 110/462 (24%), Positives = 191/462 (41%), Gaps = 53/462 (11%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT- 620
+LDG+ +S L+ + MV S +T+ + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMALLFMHDVKVATKYVKKVTGKLA 635
Query 621 -------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
V +R I EW + + W + L+ G+F + G I SD + +
Sbjct 636 VRFKALGVAVVRKITEWFDLAVDTAAS--AAGWLCYQ-LVNGLFAVANGGITFLSD-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A K +Y + K +
Sbjct 692 LVKNFVDKFKVFFKVLIDSMSVSVLSGLTVVKTASNRVCLAGCK-VYE--VVQKRLSAYV 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V+ + V + L + P SF +V + L
Sbjct 749 MPVGC-NEATCLVGEIEPAVVEDDVVDVVKAPLTYQGCCKPPTSFEKICVV------DKL 801
Query 789 MLLEIKDKEQYCALSPGLLAT-NNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFEL 846
+ + D+ + + + +R K V F + V E+ + ++I F L
Sbjct 802 YMAKCGDQFYPVVVDNDTIGVLDQCWRFPCAG--KKVEFNDKPKVKEIPSTRKIKINFAL 859
Query 847 DERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEWSV 903
D D VL++ CS + V+ + E VV +AV TL P + + T + L+ +
Sbjct 860 DATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHDVIGTKVCALLNRLAE 919
Query 904 ATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPL- 962
YLFD+ GEE + +MYCSF PD+E +C ++ + E++ DD L
Sbjct 920 DYVYLFDEGGEEVIAPKMYCSFSAPDDE-----DCVAADVVDADENQGDDADDSAALVTD 974
Query 963 ---EFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEE 1001
E G + V V E + D E +IE +P E
Sbjct 975 TQEEDGVAKGQVGVAESDAR---LDQVEAFDIEKVEDPILNE 1013
Score = 57.8 bits (138), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 52/149 (35%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + VIVN AN + HG GVAGA+ KA + KE+ D +K
Sbjct 1267 ITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKSFIKETADMVKN 1326
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VG +G NL K L++VGP+ + + L+ AY++ N D ++ L+SA
Sbjct 1327 QGVCQVGECYESTGGNLCKTVLNIVGPDARGHGKQCYSFLERAYQHINKCDDVVTTLISA 1386
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N+K
Sbjct 1387 GIFSVPTDVSLTYLIGVVTKNVILVSNNK 1415
>sp|P0C6V0|R1A_CVMA5 Replicase polyprotein 1a OS=Murine coronavirus
(strain A59) OX=11142 GN=1a PE=1 SV=1
Length=4468
Score = 1860 bits (4819), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1109/2932 (38%), Positives = 1621/2932 (55%), Gaps = 142/2932 (5%)
Query 1529 SLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHV 1588
S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1599 SVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVRCSA 1654
Query 1589 NHEGKTFF----VLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSI 1644
++GK FF + +D +AF + DE L +Y + L K W G +
Sbjct 1655 IYKGKVFFQYSDLSEADLVAVKDAFGF----DEPQLLKYYTMLGMCK-WPVVVCGNYFAF 1709
Query 1645 KWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGD 1704
K ++NNCY++ L LQ L +KF QEA+ R+G F +L+LA + E D
Sbjct 1710 KQSNNNCYINVACLMLQHLSLKFPKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSD 1769
Query 1705 VRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPC 1764
+ M +L+ A+L A L VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1770 SIDFMRVVLREADLSGATCNLEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLVRGYNIAC 1828
Query 1765 VCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYR 1824
CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1829 TCGSKLV-HCTQFNVPFLICSNTPEGRKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQL 1885
Query 1825 IDGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAY 1883
D ++ K+SE KG TD Y K T + ++ LD V E +P L YY + Y
Sbjct 1886 YDACNVNKVSEAKGNFTDCLYLKNLKQTFSSVLTTFYLDDVKCVEYKPDLSQYYCESGKY 1945
Query 1884 YTEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLN 1941
YT+ I T + + NFKL A+ LN GF E +T +P
Sbjct 1946 YTKPIIKAQFRTFEKVDGVYTNFKLV--GHSIAEKLNAKLGFDCNSPFVEYKITEWPTAT 2003
Query 1942 GDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWCLRCLWSTKPVD 1997
GDVV Y + + G KP+VW H + T+ +P+ C ++ PVD
Sbjct 2004 GDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVD 2062
Query 1998 TSNSFE------VLAVEDTQGMD----------NLACES---QQPTSEEVVENPTIQ--- 2035
S + + V G D AC S + EV + P++
Sbjct 2063 VSEPTDKGPVPAAVLVTGVPGADASAGAGIAKEQKACASASVEDQVVTEVRQEPSVSAAD 2122
Query 2036 -KEVIECDVKT-TEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLA 2093
KEV VK +V G+V++ KV + L D+ ++ + NELS
Sbjct 2123 VKEVKLNGVKKPVKVEGSVVVNDPTSETKVVKSLSIVDVYDMFLTGCKYVVWTANELSRL 2182
Query 2094 LGLKTIATHGIAAINSVPWS--KILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFT 2151
+ T+ + V W KI+ K L + K + + Y +
Sbjct 2183 VNSPTVREY-------VKWGMGKIVTPAKLLLLRDEKQEFVAPKVVKAKAIACYCAVKWF 2235
Query 2152 LLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTIA 2207
LL+ +T++++ + T +A K KLC A N +++ +S F +A
Sbjct 2236 LLYCFSWIKFNTDNKVIYT--TEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLVA 2290
Query 2208 MWLLLLSICLGSLICVTAAFGVLLSNFGA-PSYCNGVRELYLNSSNVTTM---------- 2256
LL L + + ++ + L N G P++ + + + V+T+
Sbjct 2291 TVFLLWFNFLYANVILSDFY---LPNIGPLPTFVGQIVAWFKTTFGVSTICDFYQVTDLG 2347
Query 2257 ---DFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEWVLAYMLF 2311
FC GS C +C SG D LD+Y A+ +Q V D +++ L E V+ Y L+
Sbjct 2348 YRSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRLSFDYISLFKLVVELVIGYSLY 2407
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYY 2369
T FY L + MQ+ + F+ + W + + M P ++R YI + Y
Sbjct 2408 TVCFYPLFVLIGMQLLTTWLPEFFMLETMHWSARLFVFVANMLPAFTLLRFYIVVTAMYK 2467
Query 2370 IWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNC 2429
++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNC
Sbjct 2468 VYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQWNC 2527
Query 2430 LNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKT 2489
LNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ+
Sbjct 2528 LNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVTEVKQVGCSMRLFYERDGQRV 2587
Query 2490 YERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLL 2549
Y+ S FV+++ L + KG +V+V + ++ D++ A+V+Y+Q + +P+L++
Sbjct 2588 YDDVNASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLGAAVFYAQSLYRPMLMV 2645
Query 2550 DQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLST 2609
++ L++ VS MFD YVD+ V + L + V AH+ L +GV L+ V+ T
Sbjct 2646 EKKLITTANTGLSVSRTMFDLYVDSLLNVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDT 2705
Query 2610 FVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGAC 2668
F+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG
Sbjct 2706 FIGCARRKCAIDSDVETKSITKSVMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVL 2765
Query 2669 IDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVV 2728
I NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V
Sbjct 2766 IQNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANV 2825
Query 2729 NVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKA 2788
++TT SLKGG + S + + A L+C + V + +MP + + D +K
Sbjct 2826 PILTTPFSLKGGAVFSRMLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASFKV 2882
Query 2789 IQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGL 2846
I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG + +
Sbjct 2883 IDNGVLRDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVIDQDIGHTLFNV 2942
Query 2847 PGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKP 2906
P TVLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P
Sbjct 2943 PTTVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTP 3001
Query 2907 VPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGT 2965
PYCY ++ + YS L P RY L + I+FP EG VRVV T YCR G
Sbjct 3002 HPYCYTGGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRVGL 3061
Query 2966 CERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVV 3025
CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS V
Sbjct 3062 CEEAEEGICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSV 3121
Query 3026 AGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVF 3085
AG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ F
Sbjct 3122 AGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACF 3181
Query 3086 YLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRK---RV 3142
Y Y T YF +++S + HLQW M+ I+P W IYV + H W F+ Y RK V
Sbjct 3182 YFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFS-YCRKIGTEV 3240
Query 3143 MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
+G TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +
Sbjct 3241 RSDG----TFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAA 3294
Query 3203 YREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT
Sbjct 3295 YREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCIVSVT 3354
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHS 3321
G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V +G + L V+ +
Sbjct 3355 YGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSGRMSLTVMSYQ 3414
Query 3322 MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFL 3381
MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + +R +HTIKGSFL
Sbjct 3415 MQGCQLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVTLRSSHTIKGSFL 3474
Query 3382 NGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTIT 3441
GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T
Sbjct 3475 CGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQT 3534
Query 3442 LNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAV 3501
+NV+AWLYAA+ N WF+ + +L +FN+ AM + + D V L L++ TG+ V
Sbjct 3535 VNVVAWLYAAIFNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTV 3592
Query 3502 LDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWML 3561
+ AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L
Sbjct 3593 EQVLAAIKR-LHSGFQGKQILGSCVLEDE-TPSDVYQQLAGVKLQSKRTRVIKGTCCWIL 3650
Query 3562 LTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSL 3621
+ I+ +W++F +V + L TL + + AMLL+KHKH +L ++++P L
Sbjct 3651 ASTFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLIKHKHLYLTMYIMPVL 3709
Query 3622 ATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASA-LVLLILMTARTVYDD 3680
T +V S+ WL ++ Y D V+Y LV ++ +T R++ D
Sbjct 3710 CTFYTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHD 3768
Query 3681 AARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCV 3740
++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3769 VFSIMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKW 3824
Query 3741 EYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRY 3799
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RY
Sbjct 3825 LAVNVLYFTDVPQIKLVLLSYLCIGYVCCCYWGILSLLNSIFRMPLGVYNYKISVQELRY 3884
Query 3800 MNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVE 3859
MN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L +
Sbjct 3885 MNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHIA 3944
Query 3860 SSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLD 3913
S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ +
Sbjct 3945 SNSKLWQYCSTLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVR 4004
Query 3914 NRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDA 3972
+ LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD
Sbjct 4005 DNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDR 4064
Query 3973 AMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDG 4032
A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA G
Sbjct 4065 AVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKG 4124
Query 4033 CVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEIN 4092
CVPLN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI+
Sbjct 4125 CVPLNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQFIQDADGAVKQLNEID 4184
Query 4093 MDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN 4150
++++ WPL++ A R N S V LQNNEL P LR +G+ T YYN
Sbjct 4185 VNST----WPLVIAANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYN 4238
Query 4151 NSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKG 4210
+ G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG
Sbjct 4239 TTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKG 4297
Query 4211 LNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITN 4270
N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+TN
Sbjct 4298 CNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIKQGGVPVTN 4357
Query 4271 CVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIP 4330
CVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P
Sbjct 4358 CVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVP 4417
Query 4331 TTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
DPV + L + VC VCG W+ CSC QS D + FLNGF V
Sbjct 4418 LG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQF-QSKD-TNFLNGFGV 4466
Score = 82.4 bits (202), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 52/149 (35%), Positives = 77/149 (52%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + N VIVN AN + HG GVAGA+ + A KE+ D +K
Sbjct 1320 ITPNVCFVKGDVIKVVRLVNAEVIVNPANGRMAHGAGVAGAIAEKAGSAFIKETSDMVKA 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VG +G L KK L++VGP+ + + LL+ AY++ N D ++ L+SA
Sbjct 1380 QGVCQVGECYESAGGKLCKKVLNIVGPDARGHGKQCYSLLERAYQHINKCDNVVTTLISA 1439
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N++
Sbjct 1440 GIFSVPTDVSLTYLLGVVTKNVILVSNNQ 1468
Score = 78.6 bits (192), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 111/455 (24%), Positives = 194/455 (43%), Gaps = 66/455 (15%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT- 620
+LDG+ +S L+ + MV S +T+ + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMALLFMHDVKVATKYVKKVTGKLA 635
Query 621 -------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
V +R I EW + L+ + W + L+ G+F + G I + + +
Sbjct 636 VRFKALGVAVVRKITEWFD--LAVDIAASAAGWLCYQ-LVNGLFAVANGVITFVQE-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A SK +Y + K +
Sbjct 692 LVKNFVDKFKAFFKVLIDSMSVSILSGLTVVKTASNRVCLAGSK-VYE--VVQKSLSAYV 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V + V + L + P SF IV + L
Sbjct 749 MPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLTYQGCCKPPTSFEKICIV------DKL 801
Query 789 MLLEIKDKEQYCAL---SPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITF 844
+ + D+ + + G+L F G K V F + V ++ + ++ITF
Sbjct 802 YMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG----KKVEFNDKPKVRKIPSTRKIKITF 857
Query 845 ELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEW 901
LD D VL++ CS + V+ + E VV +AV TL P + + T + LD
Sbjct 858 ALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHDVIGTKVCALLDRL 917
Query 902 SVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLP 961
+ YLFD+ G+E + RMYCSF PD+E +C ++ + E++ +DD
Sbjct 918 AGDYVYLFDEGGDEVIAPRMYCSFSAPDDE-----DCVAADVVDADENQ---DDD----- 964
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPE 996
A V V + +EE D + ++E + E
Sbjct 965 ----AEDSAVLVADTQEE----DGVAKGQVEADSE 991
>sp|P0C6V1|R1A_CVMJH Replicase polyprotein 1a OS=Murine coronavirus
(strain JHM) OX=11144 GN=1a PE=1 SV=1
Length=4474
Score = 1854 bits (4803), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1097/2938 (37%), Positives = 1609/2938 (55%), Gaps = 147/2938 (5%)
Query 1529 SLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHV 1588
S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1598 SVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVRCSA 1653
Query 1589 NHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWAD 1648
H+GK FF A + DE L +Y S L K W G + K ++
Sbjct 1654 IHKGKVFFQYSGLSAADLAAVKDAFGFDEPQLLQYYSMLGMCK-WPVVVCGNYFAFKQSN 1712
Query 1649 NNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRET 1708
NNCY++ L LQ L +KF + R+G F +L+LA + E D +
Sbjct 1713 NNCYINVACLMLQHLSLKFPKWQWRRPGNEFRSGKPLRFVSLVLAKGSFKFNEPSDSTDF 1772
Query 1709 MTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
+ L+ A+L A L +CK CG K GV+AVM+ GTL L G +I C CG
Sbjct 1773 IRVELREADLSGATCDLEFICK-CGVKQEQRKGVDAVMHFGTLDKSGLVKGYNIACTCG- 1830
Query 1769 DATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGA 1828
D + Q F++ S P KL + AN +TG GHYTH+ K D
Sbjct 1831 DKLVHCTQFNVPFLICSNTPEGKKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLYDAC 1888
Query 1829 HLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQ 1887
+++K+SE KG TD Y K T + +Y LD V +P L YY + YYT +
Sbjct 1889 NVSKVSEAKGNFTDCLYLKNLKQTFSSVLTTYYLDDVKCVAYKPDLSQYYCESGKYYT-K 1947
Query 1888 PIDLVPTQPLPNAS--FDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
PI + + NFKL A+ LN GF E +T +P GDV
Sbjct 1948 PIIKAQFRTFEKVEGVYTNFKLV--GHDIAEKLNAKLGFDCNSPFMEYKITEWPTATGDV 2005
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDTSN 2000
V Y + + G KP++W ++ + + +P+ C ++ PVD S
Sbjct 2006 VLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDVSE 2064
Query 2001 SFE--------------------VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
+ ++ E + AC S + V+E QK+
Sbjct 2065 PTDRRPVPSAVLVTGAASGADASAISTEPGTAKEQKACASDSVEDQIVME---AQKKSSV 2121
Query 2041 CDVKTTEVVGNVILKP-----------SDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
V EV N + KP KV + L D+ ++ + NE
Sbjct 2122 TTVAVKEVKLNGVKKPVKWNCSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWTANE 2181
Query 2090 LSLALGLKTIATHGIAAINSVPW--SKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMP 2147
LS + T+ + V W SK++ L + K + + Y
Sbjct 2182 LSRLINSPTVREY-------VKWGMSKLIIPANLLLLRDEKQEFVAPKVVKAKAIACYGA 2234
Query 2148 YVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KL 2203
+ LL+ +T++++ + T +A K KLC A N +++ +S
Sbjct 2235 VKWFLLYCFSWIKFNTDNKVIYT--TEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGF 2289
Query 2204 FTIA-MWLLLLSICLGSLIC--------------VTAAFGVLLSNFGAPSYCN--GVREL 2246
F +A ++LL + ++I V + + FG + C+ V +L
Sbjct 2290 FLVATVFLLWFNFLYANVILSDFYLPNIGPLPMFVGQIVAWVKTTFGVLTICDFYQVTDL 2349
Query 2247 YLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEW 2304
SS FC GS C +C SG D LD+Y ++ +Q V D +++ L E
Sbjct 2350 GYRSS------FCNGSMVCELCFSGFDMLDNYESINVVQHVVDRRVSFDYISLFKLVVEL 2403
Query 2305 VLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYI 2362
V+ Y L+T FY L + MQ+ + F+ + W + + M P ++R YI
Sbjct 2404 VIGYSLYTVCFYPLFVLVGMQLLTTWLPEFFMLGTMHWSARLFVFVANMLPAFTLLRFYI 2463
Query 2363 FFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFC 2422
+ Y ++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC
Sbjct 2464 VVTAMYKVYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFC 2523
Query 2423 KTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYF 2482
H WNCLNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++
Sbjct 2524 TKHQWNCLNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVIEVKQVGCSMRLFY 2583
Query 2483 DKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLM 2542
++ GQ+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q +
Sbjct 2584 ERDGQRVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSL 2641
Query 2543 CQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVA 2602
+P+L++++ L++ VS MFD YV + V + L + V AH+ L +GV
Sbjct 2642 YRPMLMVEKKLITTANTGLSVSRTMFDLYVYSLLRHLDVDRKSLTSFVNAAHNSLKEGVQ 2701
Query 2603 LDGVLSTFVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMT 2661
L+ V+ TFV AR+ +D+DV+TK + + + + ++ +EVT +SCNN + TY K + +
Sbjct 2702 LEQVMDTFVGCARRKCAIDSDVETKSITKSVMAAVNAGVEVTDESCNNLVPTYVKSDTIV 2761
Query 2662 PRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTC 2721
DLG I NA+H+ + VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2762 AADLGVLIQNNAKHVQSNVAKAANVACIWSVDAFNQLSADLQHRLRKACVKTGLKIKLTY 2821
Query 2722 ATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTN 2781
V ++TT SLKGG + S + + A L+C + V + +MP + + D
Sbjct 2822 NKQEANVPILTTPFSLKGGAVFSRVLQWLFVANLICFI---VLWALMPTYAVHKSDMQLP 2878
Query 2782 EIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREI 2839
+K I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++I
Sbjct 2879 LYASFKVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLVYYRNSKACPVVVAVIDQDI 2938
Query 2840 GFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIF 2899
G + +P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+
Sbjct 2939 GHTLFNVPTKVLR-YGFHVLHFITHAFATDRVQCYTPHMQIPYDNFYASGCVLSSLCTML 2997
Query 2900 KDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDA 2958
A G P PYCY ++ + YS L P RY L + I+FP EG VRVV T
Sbjct 2998 AHADGTPHPYCYTEGVMHNASLYSSLVPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSM 3057
Query 2959 EYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGAL 3018
YCR G CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LVQP+
Sbjct 3058 TYCRVGLCEEAEEGICFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVQPIDFF 3117
Query 3019 DVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFL 3078
++AS VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L
Sbjct 3118 ALTASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTL 3177
Query 3079 PGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYL 3138
+Y+ FY Y T YF +++S + HLQW M+ I+P W YV + H W F+ Y
Sbjct 3178 SCLYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCITYVAVVVSNHALWLFS-YC 3236
Query 3139 RKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGAL 3198
RK + + + TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +
Sbjct 3237 RK-IGTDVRSDGTFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKM 3293
Query 3199 DTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
DT +YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+
Sbjct 3294 DTATYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCV 3353
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V VT G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V + + L V
Sbjct 3354 VSVTYGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSDRMSLTV 3413
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+ + MQ LL L V NP TPKY F ++PG+TF+VLA YNG P G + MR +HTIK
Sbjct 3414 MSYQMQGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVVMRSSHTIK 3473
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D
Sbjct 3474 GSFLCGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQD 3533
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
T T+NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ T
Sbjct 3534 YTQTVNVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMT 3591
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTH 3557
G+ V + AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT
Sbjct 3592 GVTVEQVLAAIKR-LHSGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVIKGTC 3650
Query 3558 HWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFL 3617
W+L + I+ +W++F +V + L TL + AMLL+KHKH +L +++
Sbjct 3651 CWILASTFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVIFAMLLIKHKHLYLTMYI 3709
Query 3618 LPSLATVAYFNMVYMPASWVMRIM--TWLELADTSLSGYRLKDCVMYASA-LVLLILMTA 3674
+P L T+ Y N + + R + WL ++ Y D V+Y LV ++ +T
Sbjct 3710 MPVLCTLFYTNYLVVGYKQSFRGLAYAWLSYFVPAVD-YTYMDEVLYGVVLLVAMVFVTM 3768
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R++ D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A
Sbjct 3769 RSINHDVFSTMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATA 3824
Query 3735 IVFVCVEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
V +L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S
Sbjct 3825 KVIAKWLAVNVLYFTDIPQIKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKIS 3884
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
QE RYMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ L
Sbjct 3885 VQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCL 3944
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRL 3907
Q L + S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I +
Sbjct 3945 QHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEV 4004
Query 3908 CEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKS 3966
++ + + LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS
Sbjct 4005 SDDYVRDNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKS 4064
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I+
Sbjct 4065 AYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSIL 4124
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+NA GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD +
Sbjct 4125 DNAVKGCVPLNAIPPLTSNTLTIIVPDKQVFDQVVDNVYVTYAPNVWHIQSIQDADGAVK 4184
Query 4087 QLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDN 4144
QL+EI+++++ WPL+++A R N S V LQNNEL P LR +G+ +
Sbjct 4185 QLNEIDVNST----WPLVISANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNC--NIP 4238
Query 4145 ALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKY 4204
YYN + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KY
Sbjct 4239 TQCYYNTTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKY 4297
Query 4205 LYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASG 4264
LYF+KG N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ G
Sbjct 4298 LYFVKGCNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIQQG 4357
Query 4265 GQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKG 4324
G P+TNCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+G
Sbjct 4358 GVPVTNCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRG 4417
Query 4325 KYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
K+VQ+P DPV + L + VC VCG W+ CSC QS D + FLNGF V
Sbjct 4418 KFVQVPLG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQF-QSKD-TNFLNGFGV 4472
Score = 74.7 bits (182), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 98/390 (25%), Positives = 165/390 (42%), Gaps = 45/390 (12%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTV 621
+LDG+ +S L+ + MV S + + + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSLMVNFSREVVDMCMDMALLFMHDVKVATKYVKKVTGKVA 635
Query 622 EK--------LRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
+ +R I EW + + W + L+ G+F + G I + + +
Sbjct 636 VRFKALGIAVVRKITEWFDLAVDTAAS--AAGWLCYQ-LVNGLFAVANGVITFIQE-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A SK +Y + K +
Sbjct 692 LVKNFVDKFKTFFKVLIDSMSVSILSGLTVVKTASNRVCLAGSK-VYE--VVQKSLPAYI 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V + V + L + P SF IV + L
Sbjct 749 MPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLTYQGCCKPPSSFEKICIV------DKL 801
Query 789 MLLEIKDKEQYCAL---SPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITF 844
+ + D+ + + G+L F G K V F + V EV + ++I F
Sbjct 802 YMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG----KKVVFNDKPKVKEVPSTRKIKIIF 857
Query 845 ELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEW 901
LD D VL++ CS + V+ + E VV +AV TL P + + T + L+
Sbjct 858 ALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHGVIGTKVCALLERL 917
Query 902 SVATFYLFDDAGEENFSSRMYCSFYPPDEE 931
YLFD+ GEE +SRMYCSF PDE+
Sbjct 918 VDDYVYLFDEGGEEVIASRMYCSFSAPDED 947
Score = 59.7 bits (143), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 54/149 (36%), Positives = 77/149 (52%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + VIVN AN + HG GVAGA+ KA A E+ D +K
Sbjct 1319 ITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKAFINETADMVKA 1378
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VGG +G L KK L++VGP+ + E LL+ AY++ N D ++ L+SA
Sbjct 1379 QGVCQVGGCYESTGGKLCKKVLNIVGPDARGHGNECYSLLERAYQHINKCDNVVTTLISA 1438
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N++
Sbjct 1439 GIFSVPTDVSLTYLLGVVTKNVILVSNNQ 1467
Score = 41.6 bits (96), Expect = 0.28, Method: Compositional matrix adjust.
Identities = 50/202 (25%), Positives = 82/202 (41%), Gaps = 21/202 (10%)
Query 1573 PTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSE-AFEYYHTLDESFLGRYMSALNHTK 1631
P ++ D+ K++ + E +T P+D T AF+ ++ S S H K
Sbjct 1047 PDQVEAFDIEKVEDSILSELQTELNAPADKTYEDVLAFDAIYSETLSAFYAVPSDETHFK 1106
Query 1632 KWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI 1691
V G S NC+L S L+ +Q L ++F +Q+ + +AG F +
Sbjct 1107 ------VCGFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKL 1160
Query 1692 LAYSNKTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMG 1749
+ + K++ + G V + L S K N C CG + L G++AV + G
Sbjct 1161 VKSAPKSIILPQGGYVADFAYFFLSQC---SFKVHANWRCLKCGME-LKLQGLDAVFFYG 1216
Query 1750 TLSYDNLKTGVSIPCVCGRDAT 1771
+ VS C CG T
Sbjct 1217 DV--------VSHMCKCGNSMT 1230
>sp|P0C6X9|R1AB_CVMA5 Replicase polyprotein 1ab OS=Murine coronavirus
(strain A59) OX=11142 GN=rep PE=1 SV=1
Length=7176
Score = 1852 bits (4797), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1101/2910 (38%), Positives = 1609/2910 (55%), Gaps = 140/2910 (5%)
Query 1529 SLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHV 1588
S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1599 SVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVRCSA 1654
Query 1589 NHEGKTFF----VLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSI 1644
++GK FF + +D +AF + DE L +Y + L K W G +
Sbjct 1655 IYKGKVFFQYSDLSEADLVAVKDAFGF----DEPQLLKYYTMLGMCK-WPVVVCGNYFAF 1709
Query 1645 KWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGD 1704
K ++NNCY++ L LQ L +KF QEA+ R+G F +L+LA + E D
Sbjct 1710 KQSNNNCYINVACLMLQHLSLKFPKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSD 1769
Query 1705 VRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPC 1764
+ M +L+ A+L A L VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1770 SIDFMRVVLREADLSGATCNLEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLVRGYNIAC 1828
Query 1765 VCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYR 1824
CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1829 TCGSKLV-HCTQFNVPFLICSNTPEGRKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQL 1885
Query 1825 IDGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAY 1883
D ++ K+SE KG TD Y K T + ++ LD V E +P L YY + Y
Sbjct 1886 YDACNVNKVSEAKGNFTDCLYLKNLKQTFSSVLTTFYLDDVKCVEYKPDLSQYYCESGKY 1945
Query 1884 YTEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLN 1941
YT+ I T + + NFKL A+ LN GF E +T +P
Sbjct 1946 YTKPIIKAQFRTFEKVDGVYTNFKLV--GHSIAEKLNAKLGFDCNSPFVEYKITEWPTAT 2003
Query 1942 GDVVAIDYRHYSASFKKGAKLLHKPIVW--HINQATTKTTF--KPNTWCLRCLWSTKPVD 1997
GDVV Y + + G KP+VW H + T+ +P+ C ++ PVD
Sbjct 2004 GDVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVD 2062
Query 1998 TSNSFE------VLAVEDTQGMD----------NLACES---QQPTSEEVVENPTIQ--- 2035
S + + V G D AC S + EV + P++
Sbjct 2063 VSEPTDKGPVPAAVLVTGVPGADASAGAGIAKEQKACASASVEDQVVTEVRQEPSVSAAD 2122
Query 2036 -KEVIECDVKT-TEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLA 2093
KEV VK +V G+V++ KV + L D+ ++ + NELS
Sbjct 2123 VKEVKLNGVKKPVKVEGSVVVNDPTSETKVVKSLSIVDVYDMFLTGCKYVVWTANELSRL 2182
Query 2094 LGLKTIATHGIAAINSVPWS--KILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFT 2151
+ T+ + V W KI+ K L + K + + Y +
Sbjct 2183 VNSPTVREY-------VKWGMGKIVTPAKLLLLRDEKQEFVAPKVVKAKAIACYCAVKWF 2235
Query 2152 LLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTIA 2207
LL+ +T++++ + T +A K KLC A N +++ +S F +A
Sbjct 2236 LLYCFSWIKFNTDNKVIYT--TEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLVA 2290
Query 2208 MWLLLLSICLGSLICVTAAFGVLLSNFGA-PSYCNGVRELYLNSSNVTTM---------- 2256
LL L + + ++ + L N G P++ + + + V+T+
Sbjct 2291 TVFLLWFNFLYANVILSDFY---LPNIGPLPTFVGQIVAWFKTTFGVSTICDFYQVTDLG 2347
Query 2257 ---DFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEWVLAYMLF 2311
FC GS C +C SG D LD+Y A+ +Q V D +++ L E V+ Y L+
Sbjct 2348 YRSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRLSFDYISLFKLVVELVIGYSLY 2407
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYY 2369
T FY L + MQ+ + F+ + W + + M P ++R YI + Y
Sbjct 2408 TVCFYPLFVLIGMQLLTTWLPEFFMLETMHWSARLFVFVANMLPAFTLLRFYIVVTAMYK 2467
Query 2370 IWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNC 2429
++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNC
Sbjct 2468 VYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQWNC 2527
Query 2430 LNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKT 2489
LNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ+
Sbjct 2528 LNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVTEVKQVGCSMRLFYERDGQRV 2587
Query 2490 YERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLL 2549
Y+ S FV+++ L + KG +V+V + ++ D++ A+V+Y+Q + +P+L++
Sbjct 2588 YDDVNASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLGAAVFYAQSLYRPMLMV 2645
Query 2550 DQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLST 2609
++ L++ VS MFD YVD+ V + L + V AH+ L +GV L+ V+ T
Sbjct 2646 EKKLITTANTGLSVSRTMFDLYVDSLLNVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDT 2705
Query 2610 FVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGAC 2668
F+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG
Sbjct 2706 FIGCARRKCAIDSDVETKSITKSVMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVL 2765
Query 2669 IDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVV 2728
I NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V
Sbjct 2766 IQNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANV 2825
Query 2729 NVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKA 2788
++TT SLKGG + S + + A L+C + V + +MP + + D +K
Sbjct 2826 PILTTPFSLKGGAVFSRMLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASFKV 2882
Query 2789 IQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGL 2846
I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG + +
Sbjct 2883 IDNGVLRDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVIDQDIGHTLFNV 2942
Query 2847 PGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKP 2906
P TVLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P
Sbjct 2943 PTTVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTP 3001
Query 2907 VPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGT 2965
PYCY ++ + YS L P RY L + I+FP EG VRVV T YCR G
Sbjct 3002 HPYCYTGGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRVGL 3061
Query 2966 CERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVV 3025
CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS V
Sbjct 3062 CEEAEEGICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSV 3121
Query 3026 AGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVF 3085
AG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ F
Sbjct 3122 AGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACF 3181
Query 3086 YLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRK---RV 3142
Y Y T YF +++S + HLQW M+ I+P W IYV + H W F+ Y RK V
Sbjct 3182 YFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFS-YCRKIGTEV 3240
Query 3143 MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
+G TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +
Sbjct 3241 RSDG----TFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAA 3294
Query 3203 YREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT
Sbjct 3295 YREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCIVSVT 3354
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHS 3321
G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V +G + L V+ +
Sbjct 3355 YGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSGRMSLTVMSYQ 3414
Query 3322 MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFL 3381
MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + +R +HTIKGSFL
Sbjct 3415 MQGCQLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVTLRSSHTIKGSFL 3474
Query 3382 NGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTIT 3441
GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T
Sbjct 3475 CGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQT 3534
Query 3442 LNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAV 3501
+NV+AWLYAA+ N WF+ + +L +FN+ AM + + D V L L++ TG+ V
Sbjct 3535 VNVVAWLYAAIFNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTV 3592
Query 3502 LDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWML 3561
+ AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L
Sbjct 3593 EQVLAAIKR-LHSGFQGKQILGSCVLEDE-TPSDVYQQLAGVKLQSKRTRVIKGTCCWIL 3650
Query 3562 LTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSL 3621
+ I+ +W++F +V + L TL + + AMLL+KHKH +L ++++P L
Sbjct 3651 ASTFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLIKHKHLYLTMYIMPVL 3709
Query 3622 ATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASA-LVLLILMTARTVYDD 3680
T +V S+ WL ++ Y D V+Y LV ++ +T R++ D
Sbjct 3710 CTFYTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHD 3768
Query 3681 AARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCV 3740
++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3769 VFSIMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKW 3824
Query 3741 EYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRY 3799
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RY
Sbjct 3825 LAVNVLYFTDVPQIKLVLLSYLCIGYVCCCYWGILSLLNSIFRMPLGVYNYKISVQELRY 3884
Query 3800 MNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVE 3859
MN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L +
Sbjct 3885 MNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHIA 3944
Query 3860 SSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLD 3913
S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ +
Sbjct 3945 SNSKLWQYCSTLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVR 4004
Query 3914 NRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDA 3972
+ LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD
Sbjct 4005 DNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDR 4064
Query 3973 AMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDG 4032
A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA G
Sbjct 4065 AVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKG 4124
Query 4033 CVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEIN 4092
CVPLN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI+
Sbjct 4125 CVPLNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQFIQDADGAVKQLNEID 4184
Query 4093 MDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN 4150
+ N WPL++ A R N S V LQNNEL P LR +G+ T YYN
Sbjct 4185 V----NSTWPLVIAANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYN 4238
Query 4151 NSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKG 4210
+ G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG
Sbjct 4239 TTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKG 4297
Query 4211 LNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITN 4270
N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+TN
Sbjct 4298 CNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIKQGGVPVTN 4357
Query 4271 CVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIP 4330
CVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P
Sbjct 4358 CVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVP 4417
Query 4331 TTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
DPV + L + VC VCG W+ CSC
Sbjct 4418 LG-IKDPVSYVLTHDVCQVCGFWRDGSCSC 4446
Score = 82.4 bits (202), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 52/149 (35%), Positives = 77/149 (52%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + N VIVN AN + HG GVAGA+ + A KE+ D +K
Sbjct 1320 ITPNVCFVKGDVIKVVRLVNAEVIVNPANGRMAHGAGVAGAIAEKAGSAFIKETSDMVKA 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VG +G L KK L++VGP+ + + LL+ AY++ N D ++ L+SA
Sbjct 1380 QGVCQVGECYESAGGKLCKKVLNIVGPDARGHGKQCYSLLERAYQHINKCDNVVTTLISA 1439
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N++
Sbjct 1440 GIFSVPTDVSLTYLLGVVTKNVILVSNNQ 1468
Score = 78.6 bits (192), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 102/407 (25%), Positives = 177/407 (43%), Gaps = 48/407 (12%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT- 620
+LDG+ +S L+ + MV S +T+ + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMALLFMHDVKVATKYVKKVTGKLA 635
Query 621 -------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
V +R I EW + L+ + W + L+ G+F + G I + + +
Sbjct 636 VRFKALGVAVVRKITEWFD--LAVDIAASAAGWLCYQ-LVNGLFAVANGVITFVQE-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A SK +Y + K +
Sbjct 692 LVKNFVDKFKAFFKVLIDSMSVSILSGLTVVKTASNRVCLAGSK-VYE--VVQKSLSAYV 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V + V + L + P SF IV + L
Sbjct 749 MPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLTYQGCCKPPTSFEKICIV------DKL 801
Query 789 MLLEIKDKEQYCAL---SPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITF 844
+ + D+ + + G+L F G K V F + V ++ + ++ITF
Sbjct 802 YMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG----KKVEFNDKPKVRKIPSTRKIKITF 857
Query 845 ELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEW 901
LD D VL++ CS + V+ + E VV +AV TL P + + T + LD
Sbjct 858 ALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHDVIGTKVCALLDRL 917
Query 902 SVATFYLFDDAGEENFSSRMYCSFYPPDEEE---EDDAECEEEEIDE 945
+ YLFD+ G+E + RMYCSF PD+E+ D + +E + D+
Sbjct 918 AGDYVYLFDEGGDEVIAPRMYCSFSAPDDEDCVAADVVDADENQDDD 964
>sp|P0C6Y0|R1AB_CVMJH Replicase polyprotein 1ab OS=Murine coronavirus
(strain JHM) OX=11144 GN=rep PE=1 SV=1
Length=7180
Score = 1846 bits (4781), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1089/2916 (37%), Positives = 1598/2916 (55%), Gaps = 145/2916 (5%)
Query 1529 SLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHV 1588
S+ ++++LL+ + V TVD N + V +G+ G + DG +VTK++
Sbjct 1598 SVSQIRALLA----NKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVRCSA 1653
Query 1589 NHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWAD 1648
H+GK FF A + DE L +Y S L K W G + K ++
Sbjct 1654 IHKGKVFFQYSGLSAADLAAVKDAFGFDEPQLLQYYSMLGMCK-WPVVVCGNYFAFKQSN 1712
Query 1649 NNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRET 1708
NNCY++ L LQ L +KF + R+G F +L+LA + E D +
Sbjct 1713 NNCYINVACLMLQHLSLKFPKWQWRRPGNEFRSGKPLRFVSLVLAKGSFKFNEPSDSTDF 1772
Query 1709 MTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
+ L+ A+L A L +CK CG K GV+AVM+ GTL L G +I C CG
Sbjct 1773 IRVELREADLSGATCDLEFICK-CGVKQEQRKGVDAVMHFGTLDKSGLVKGYNIACTCG- 1830
Query 1769 DATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGA 1828
D + Q F++ S P KL + AN +TG GHYTH+ K D
Sbjct 1831 DKLVHCTQFNVPFLICSNTPEGKKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLYDAC 1888
Query 1829 HLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQ 1887
+++K+SE KG TD Y K T + +Y LD V +P L YY + YYT +
Sbjct 1889 NVSKVSEAKGNFTDCLYLKNLKQTFSSVLTTYYLDDVKCVAYKPDLSQYYCESGKYYT-K 1947
Query 1888 PIDLVPTQPLPNAS--FDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
PI + + NFKL + A+ LN GF E +T +P GDV
Sbjct 1948 PIIKAQFRTFEKVEGVYTNFKLVGHD--IAEKLNAKLGFDCNSPFMEYKITEWPTATGDV 2005
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDTSN 2000
V Y + + G KP++W ++ + + +P+ C ++ PVD S
Sbjct 2006 VLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDVSE 2064
Query 2001 SFE--------------------VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
+ ++ E + AC S + V+E QK+
Sbjct 2065 PTDRRPVPSAVLVTGAASGADASAISTEPGTAKEQKACASDSVEDQIVME---AQKKSSV 2121
Query 2041 CDVKTTEVVGNVILKP-----------SDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
V EV N + KP KV + L D+ ++ + NE
Sbjct 2122 TTVAVKEVKLNGVKKPVKWNCSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWTANE 2181
Query 2090 LSLALGLKTIATHGIAAINSVPW--SKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMP 2147
LS + T+ + V W SK++ L + K + + Y
Sbjct 2182 LSRLINSPTVREY-------VKWGMSKLIIPANLLLLRDEKQEFVAPKVVKAKAIACYGA 2234
Query 2148 YVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KL 2203
+ LL+ +T++++ + T +A K KLC A N +++ +S
Sbjct 2235 VKWFLLYCFSWIKFNTDNKVIYT--TEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGF 2289
Query 2204 FTIA-MWLLLLSICLGSLIC--------------VTAAFGVLLSNFGAPSYCN--GVREL 2246
F +A ++LL + ++I V + + FG + C+ V +L
Sbjct 2290 FLVATVFLLWFNFLYANVILSDFYLPNIGPLPMFVGQIVAWVKTTFGVLTICDFYQVTDL 2349
Query 2247 YLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQ-VTISSYKLD-LTILGLAAEW 2304
SS FC GS C +C SG D LD+Y ++ +Q V D +++ L E
Sbjct 2350 GYRSS------FCNGSMVCELCFSGFDMLDNYESINVVQHVVDRRVSFDYISLFKLVVEL 2403
Query 2305 VLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYI 2362
V+ Y L+T FY L + MQ+ + F+ + W + + M P ++R YI
Sbjct 2404 VIGYSLYTVCFYPLFVLVGMQLLTTWLPEFFMLGTMHWSARLFVFVANMLPAFTLLRFYI 2463
Query 2363 FFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFC 2422
+ Y ++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC
Sbjct 2464 VVTAMYKVYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFC 2523
Query 2423 KTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYF 2482
H WNCLNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++
Sbjct 2524 TKHQWNCLNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVIEVKQVGCSMRLFY 2583
Query 2483 DKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLM 2542
++ GQ+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q +
Sbjct 2584 ERDGQRVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSL 2641
Query 2543 CQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVA 2602
+P+L++++ L++ VS MFD YV + V + L + V AH+ L +GV
Sbjct 2642 YRPMLMVEKKLITTANTGLSVSRTMFDLYVYSLLRHLDVDRKSLTSFVNAAHNSLKEGVQ 2701
Query 2603 LDGVLSTFVSAARQG-VVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMT 2661
L+ V+ TFV AR+ +D+DV+TK + + + + ++ +EVT +SCNN + TY K + +
Sbjct 2702 LEQVMDTFVGCARRKCAIDSDVETKSITKSVMAAVNAGVEVTDESCNNLVPTYVKSDTIV 2761
Query 2662 PRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTC 2721
DLG I NA+H+ + VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2762 AADLGVLIQNNAKHVQSNVAKAANVACIWSVDAFNQLSADLQHRLRKACVKTGLKIKLTY 2821
Query 2722 ATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTN 2781
V ++TT SLKGG + S + + A L+C + V + +MP + + D
Sbjct 2822 NKQEANVPILTTPFSLKGGAVFSRVLQWLFVANLICFI---VLWALMPTYAVHKSDMQLP 2878
Query 2782 EIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREI 2839
+K I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++I
Sbjct 2879 LYASFKVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLVYYRNSKACPVVVAVIDQDI 2938
Query 2840 GFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIF 2899
G + +P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+
Sbjct 2939 GHTLFNVPTKVLR-YGFHVLHFITHAFATDRVQCYTPHMQIPYDNFYASGCVLSSLCTML 2997
Query 2900 KDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDA 2958
A G P PYCY ++ + YS L P RY L + I+FP EG VRVV T
Sbjct 2998 AHADGTPHPYCYTEGVMHNASLYSSLVPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSM 3057
Query 2959 EYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGAL 3018
YCR G CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LVQP+
Sbjct 3058 TYCRVGLCEEAEEGICFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVQPIDFF 3117
Query 3019 DVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFL 3078
++AS VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L
Sbjct 3118 ALTASSVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTL 3177
Query 3079 PGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYL 3138
+Y+ FY Y T YF +++S + HLQW M+ I+P W YV + H W F+ Y
Sbjct 3178 SCLYACFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCITYVAVVVSNHALWLFS-YC 3236
Query 3139 RKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGAL 3198
RK + + + TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +
Sbjct 3237 RK-IGTDVRSDGTFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKM 3293
Query 3199 DTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
DT +YREAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+
Sbjct 3294 DTATYREAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCV 3353
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V VT G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V + + L V
Sbjct 3354 VSVTYGNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSDRMSLTV 3413
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+ + MQ LL L V NP TPKY F ++PG+TF+VLA YNG P G + MR +HTIK
Sbjct 3414 MSYQMQGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVVMRSSHTIK 3473
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D
Sbjct 3474 GSFLCGSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQD 3533
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
T T+NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ T
Sbjct 3534 YTQTVNVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMT 3591
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTH 3557
G+ V + AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT
Sbjct 3592 GVTVEQVLAAIKR-LHSGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVIKGTC 3650
Query 3558 HWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFL 3617
W+L + I+ +W++F +V + L TL + AMLL+KHKH +L +++
Sbjct 3651 CWILASTFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVIFAMLLIKHKHLYLTMYI 3709
Query 3618 LPSLATVAYFNMVYMPASWVMRIM--TWLELADTSLSGYRLKDCVMYASA-LVLLILMTA 3674
+P L T+ Y N + + R + WL ++ Y D V+Y LV ++ +T
Sbjct 3710 MPVLCTLFYTNYLVVGYKQSFRGLAYAWLSYFVPAVD-YTYMDEVLYGVVLLVAMVFVTM 3768
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R++ D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A
Sbjct 3769 RSINHDVFSTMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATA 3824
Query 3735 IVFVCVEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
V +L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S
Sbjct 3825 KVIAKWLAVNVLYFTDIPQIKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKIS 3884
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
QE RYMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ L
Sbjct 3885 VQELRYMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCL 3944
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRL 3907
Q L + S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I +
Sbjct 3945 QHLHIASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEV 4004
Query 3908 CEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKS 3966
++ + + LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS
Sbjct 4005 SDDYVRDNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKS 4064
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I+
Sbjct 4065 AYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSIL 4124
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+NA GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD +
Sbjct 4125 DNAVKGCVPLNAIPPLTSNTLTIIVPDKQVFDQVVDNVYVTYAPNVWHIQSIQDADGAVK 4184
Query 4087 QLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDN 4144
QL+EI++ N WPL+++A R N S V LQNNEL P LR +G+ +
Sbjct 4185 QLNEIDV----NSTWPLVISANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNC--NIP 4238
Query 4145 ALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKY 4204
YYN + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KY
Sbjct 4239 TQCYYNTTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKY 4297
Query 4205 LYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASG 4264
LYF+KG N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ G
Sbjct 4298 LYFVKGCNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIQQG 4357
Query 4265 GQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKG 4324
G P+TNCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+G
Sbjct 4358 GVPVTNCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRG 4417
Query 4325 KYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
K+VQ+P DPV + L + VC VCG W+ CSC
Sbjct 4418 KFVQVPLG-IKDPVSYVLTHDVCQVCGFWRDGSCSC 4452
Score = 74.7 bits (182), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 99/392 (25%), Positives = 164/392 (42%), Gaps = 49/392 (13%)
Query 569 ILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTV 621
+LDG+ +S L+ + MV S + + + MA + V+ ++++ + G
Sbjct 576 LLDGLVPRSYYLIKSGQAFTSLMVNFSREVVDMCMDMALLFMHDVKVATKYVKKVTGKVA 635
Query 622 EK--------LRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKD 673
+ +R I EW + + W + L+ G+F + G I + + +
Sbjct 636 VRFKALGIAVVRKITEWFDLAVDTAAS--AAGWLCYQ-LVNGLFAVANGVITFIQE-VPE 691
Query 674 CVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLL 730
VK F+D ++ ID ++++ G + V +A SK +Y + K +
Sbjct 692 LVKNFVDKFKTFFKVLIDSMSVSILSGLTVVKTASNRVCLAGSK-VYE--VVQKSLPAYI 748
Query 731 MPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALETPVDSFTNGAIVGTPVCVNGL 788
MP+ E T L G+ V + V + L + P SF IV
Sbjct 749 MPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLTYQGCCKPPSSFEKICIVDK------- 800
Query 789 MLLEIKDKEQYCAL-----SPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRI 842
L K +Q+ + + G+L F G K V F + V EV + ++I
Sbjct 801 -LYMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG----KKVVFNDKPKVKEVPSTRKIKI 855
Query 843 TFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLD 899
F LD D VL++ CS + V+ + E VV +AV TL P + + T + L+
Sbjct 856 IFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVESTLSPCKEHGVIGTKVCALLE 915
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEE 931
YLFD+ GEE +SRMYCSF PDE+
Sbjct 916 RLVDDYVYLFDEGGEEVIASRMYCSFSAPDED 947
Score = 59.7 bits (143), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 54/149 (36%), Positives = 77/149 (52%), Gaps = 2/149 (1%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T NV D++K + VIVN AN + HG GVAGA+ KA A E+ D +K
Sbjct 1319 ITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKAFINETADMVKA 1378
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLLSA 1129
G VGG +G L KK L++VGP+ + E LL+ AY++ N D ++ L+SA
Sbjct 1379 QGVCQVGGCYESTGGKLCKKVLNIVGPDARGHGNECYSLLERAYQHINKCDNVVTTLISA 1438
Query 1130 GIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
GIF SL + V V + N++
Sbjct 1439 GIFSVPTDVSLTYLLGVVTKNVILVSNNQ 1467
Score = 41.2 bits (95), Expect = 0.31, Method: Compositional matrix adjust.
Identities = 50/202 (25%), Positives = 82/202 (41%), Gaps = 21/202 (10%)
Query 1573 PTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSE-AFEYYHTLDESFLGRYMSALNHTK 1631
P ++ D+ K++ + E +T P+D T AF+ ++ S S H K
Sbjct 1047 PDQVEAFDIEKVEDSILSELQTELNAPADKTYEDVLAFDAIYSETLSAFYAVPSDETHFK 1106
Query 1632 KWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI 1691
V G S NC+L S L+ +Q L ++F +Q+ + +AG F +
Sbjct 1107 ------VCGFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKL 1160
Query 1692 LAYSNKTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMG 1749
+ + K++ + G V + L S K N C CG + L G++AV + G
Sbjct 1161 VKSAPKSIILPQGGYVADFAYFFLSQC---SFKVHANWRCLKCGME-LKLQGLDAVFFYG 1216
Query 1750 TLSYDNLKTGVSIPCVCGRDAT 1771
+ VS C CG T
Sbjct 1217 DV--------VSHMCKCGNSMT 1230
>sp|P0C6U4|R1A_CVHN2 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N2) OX=443240 GN=1a PE=3 SV=1
Length=4441
Score = 1819 bits (4712), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1069/2885 (37%), Positives = 1581/2885 (55%), Gaps = 110/2885 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1620 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1679
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1680 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1738
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1739 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1798
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1799 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1855
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1856 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1913
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1914 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1972
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL + LN GF E VT +P GDVV Y +
Sbjct 1973 DGVYTNFKLVGHDI--CAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2030
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2031 KGCETFGKPVIWLCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2075
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2076 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2135
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2136 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2194
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2195 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2248
Query 2196 KSPKFSKLFTIA-----MWL--LLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K F + W L +++ I V + + FG +
Sbjct 2249 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2308
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2309 CDFYSKLGVG----FTSHFCNGSFICELCYSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2364
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2365 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2424
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2425 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2484
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2485 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2544
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V +S D + +A
Sbjct 2545 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVV--VESDADRANFLNAV 2602
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2603 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2662
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2663 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2722
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2723 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDTFNQLTADLQHKLKKACVKTG 2782
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2783 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2839
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2840 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVV 2899
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2900 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2958
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2959 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3018
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3019 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3078
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3079 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3138
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3139 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3198
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3199 WLFS-YCRK-IGVNVCNDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3254
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3255 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3314
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3315 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3374
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3375 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3434
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3435 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3494
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3495 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3552
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3553 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3611
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3612 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3669
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3670 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGLTYVWLSYFVPAVNFTYVYE-VFYGCILCV 3728
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3729 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3784
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3785 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3844
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3845 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3904
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+S+LW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3905 VVLLNCLQHLHVASNSRLWQYCSILHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKC 3964
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3965 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4024
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4025 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4084
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPLN IP A L +++PD + D YA ++W IQ V
Sbjct 4085 QALNSILDNAVKGCVPLNAIPALAANTLTIIIPDKQVFDKVVDNVYVAYAGSVWHIQTVQ 4144
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGTTQ 4137
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4145 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDM 4200
Query 4138 TACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP 4197
+ YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4201 NC--NIPTQCYYNNGSSGRIVYAVLSDVDGLKYTKIIKDDGNCVV-LELDPPCKFSIQDV 4257
Query 4198 KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAY 4257
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y
Sbjct 4258 KGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTY 4317
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK 4317
DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+
Sbjct 4318 LDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVD 4377
Query 4318 GFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFL 4377
G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D + FL
Sbjct 4378 GLCKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SGVAVQSKDLN-FL 4434
Query 4378 NGFAV 4382
NGF V
Sbjct 4435 NGFGV 4439
Score = 82.8 bits (203), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1328 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1387
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1388 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1447
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1448 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1484
Score = 79.7 bits (195), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 90/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G+F + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGLFVVSQANFNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTN---GAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDQAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L D + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKDHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 44.7 bits (104), Expect = 0.026, Method: Compositional matrix adjust.
Identities = 38/137 (28%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1117 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1176
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++AV + G +
Sbjct 1177 KAIVLPQGGYVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDAVFFYGDI--- 1229
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1230 -----VSHVCKCGHNMT 1241
>sp|P0C6U5|R1A_CVHN5 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N5) OX=443241 GN=1a PE=3 SV=1
Length=4421
Score = 1815 bits (4702), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1072/2890 (37%), Positives = 1582/2890 (55%), Gaps = 120/2890 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1600 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1659
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1660 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1718
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1719 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1778
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1779 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1835
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1836 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1893
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1894 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1952
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL + LN GF E VT +P GDVV Y +
Sbjct 1953 DGVYTNFKLVGHDI--CAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2010
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2011 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2055
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2056 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2115
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2116 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2174
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2175 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2228
Query 2196 KSPKFSKLFTIA-----MWL--LLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K F + W L +++ I V + + FG +
Sbjct 2229 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2288
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2289 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2344
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2345 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2404
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2405 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2464
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2465 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2524
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V +S D + +A
Sbjct 2525 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVV--VESDADRANFLNAV 2582
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2583 VFYAQSLYRPILLVDKKLITTACNGISVTQIMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2642
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2643 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2702
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK N+S IW + + L+ L+ +++ A K
Sbjct 2703 LKSDNIVAADLGVLIQNGAKHVQGNVAKVANISCIWFIDAFNQLTADLQHKLKKACVKTG 2762
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2763 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2819
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2820 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2879
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2880 AVMDEDIGSTMFNVPTKVLRY-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2938
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2939 SSLCTMFKRGDGTPHPYCYTDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 2998
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 2999 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFSSL 3058
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3059 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3118
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3119 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3178
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3179 WLFS-YCRK-IGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3234
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3235 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3294
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3295 SKIEPCLVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3354
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3355 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3414
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3415 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFNGNFYGPYRDAQV 3474
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3475 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3532
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3533 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3591
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3592 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3649
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3650 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSHFVPAVNFTYVYE-VFYGCILCV 3708
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3709 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3764
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3765 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3824
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3825 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3884
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL S AVD
Sbjct 3885 VVLLNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFSNPAAVDTKC 3944
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3945 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4004
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4005 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4064
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPL+ IP A L +++PD + D TYA ++W IQ V
Sbjct 4065 QALNSILDNAVKGCVPLSAIPALAANTLTIIIPDKQVFDKVVDNVYVTYAGSVWHIQTVQ 4124
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGT-- 4135
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4125 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDI 4180
Query 4136 ---TQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRF 4192
T C YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4181 NCNIPTQC-------YYNNVSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKF 4232
Query 4193 VTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVD 4252
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VD
Sbjct 4233 SIQDVKGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVD 4292
Query 4253 PAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHID 4312
P K Y DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++
Sbjct 4293 PKKTYLDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVE 4352
Query 4313 HPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSAD 4372
HP+ G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D
Sbjct 4353 HPDVDGICKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKD 4410
Query 4373 ASTFLNGFAV 4382
+ FLNG V
Sbjct 4411 LN-FLNGLGV 4419
Score = 82.8 bits (203), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1308 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1367
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1368 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1427
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1428 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1464
Score = 77.8 bits (190), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 89/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G F + + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGFFVVSQANLNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTN---GAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDHAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L + + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 45.1 bits (105), Expect = 0.025, Method: Compositional matrix adjust.
Identities = 38/137 (28%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1097 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1156
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++AV + G +
Sbjct 1157 KAIVLPQGGYVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDAVFFYGDI--- 1209
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1210 -----VSHVCKCGHNMT 1221
>sp|P0C6U3|R1A_CVHN1 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N1) OX=443239 GN=1a PE=1 SV=1
Length=4471
Score = 1814 bits (4699), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1071/2885 (37%), Positives = 1583/2885 (55%), Gaps = 110/2885 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1650 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1709
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1710 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1768
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1769 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1828
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1829 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1885
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1886 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1943
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1944 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 2002
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL + LN GF E VT +P GDVV Y +
Sbjct 2003 DGVYTNFKLVGHDI--CAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2060
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2061 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2105
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2106 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2165
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2166 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2224
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2225 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2278
Query 2196 KSPKFSKLFTIA-----MWL--LLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K F + W L +++ I V + + FG +
Sbjct 2279 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2338
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2339 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2394
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2395 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2454
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2455 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2514
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2515 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2574
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V +S D + +A
Sbjct 2575 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVV--VESDADRANFLNAV 2632
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2633 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2692
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2693 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2752
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2753 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDAFNQLTADLQHKLKKACVKTG 2812
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2813 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFVSLICFI---LLWALLPTYSVY 2869
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2870 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2929
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2930 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2988
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2989 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3048
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3049 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3108
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3109 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLMLFV 3168
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3169 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3228
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3229 WLFS-YCRK-IGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3284
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3285 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3344
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC++ +M P+Y LL R + F + +
Sbjct 3345 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMNEPDYSALLCRVTLGDFTIMS 3404
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3405 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGNVKPGETFTVLAAYNGRPQGAFHVTM 3464
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3465 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3524
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ + DFN+ AM + + D V L
Sbjct 3525 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLV--L 3582
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3583 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3641
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3642 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3699
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3700 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSYFVPAVNFTYVYE-VFYGCILCV 3758
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3759 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3814
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3815 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3874
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3875 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3934
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3935 VVLLNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKC 3994
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3995 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4054
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4055 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4114
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPL+ IP A L +V+PD + D TYA ++W IQ V
Sbjct 4115 QALNSILDNAVKGCVPLSAIPALAANTLTIVIPDKQVFDKVVDNVYVTYAGSVWHIQTVQ 4174
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGTTQ 4137
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4175 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDM 4230
Query 4138 TACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP 4197
+ YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4231 NC--NIPTQCYYNNGSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDV 4287
Query 4198 KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAY 4257
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y
Sbjct 4288 KGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTY 4347
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK 4317
DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+
Sbjct 4348 LDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVD 4407
Query 4318 GFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFL 4377
G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D + FL
Sbjct 4408 GICKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKDLN-FL 4464
Query 4378 NGFAV 4382
NGF V
Sbjct 4465 NGFGV 4469
Score = 82.8 bits (203), Expect = 1e-13, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1358 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1417
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1418 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1477
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1478 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1514
Score = 77.8 bits (190), Expect = 3e-12, Method: Compositional matrix adjust.
Identities = 89/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G+F + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGLFVVSQANFNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTN---GAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDQAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L + + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 43.5 bits (101), Expect = 0.065, Method: Compositional matrix adjust.
Identities = 37/137 (27%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1147 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1206
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++A+ + G +
Sbjct 1207 KAIVLPQGGFVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDALFFYGDI--- 1259
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1260 -----VSHVCKCGHNMT 1271
>sp|P0C6X3|R1AB_CVHN2 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N2) OX=443240 GN=rep PE=3 SV=1
Length=7152
Score = 1812 bits (4694), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1058/2863 (37%), Positives = 1569/2863 (55%), Gaps = 108/2863 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1620 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1679
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1680 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1738
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1739 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1798
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1799 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1855
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1856 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1913
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1914 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1972
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 1973 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2030
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2031 KGCETFGKPVIWLCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2075
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2076 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2135
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2136 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2194
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2195 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2248
Query 2196 KSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGV----------------LLSNFGAPSY 2239
+ F K F + + L + + + F + + + FG +
Sbjct 2249 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2308
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2309 CDFYSKLGVG----FTSHFCNGSFICELCYSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2364
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2365 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2424
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2425 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2484
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2485 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2544
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V +S D + +A
Sbjct 2545 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVV--VESDADRANFLNAV 2602
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2603 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2662
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2663 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2722
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2723 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDTFNQLTADLQHKLKKACVKTG 2782
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2783 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2839
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2840 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVV 2899
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2900 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2958
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2959 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3018
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3019 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3078
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3079 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3138
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3139 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3198
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3199 WLFS-YCRK-IGVNVCNDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3254
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3255 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3314
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3315 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3374
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3375 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3434
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3435 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3494
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3495 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3552
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3553 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3611
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3612 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3669
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3670 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGLTYVWLSYFVPAVNFTYVYE-VFYGCILCV 3728
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3729 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3784
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3785 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3844
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3845 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3904
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+S+LW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3905 VVLLNCLQHLHVASNSRLWQYCSILHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKC 3964
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3965 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4024
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4025 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4084
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPLN IP A L +++PD + D YA ++W IQ V
Sbjct 4085 QALNSILDNAVKGCVPLNAIPALAANTLTIIIPDKQVFDKVVDNVYVAYAGSVWHIQTVQ 4144
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGTTQ 4137
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4145 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDM 4200
Query 4138 TACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP 4197
+ YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4201 NC--NIPTQCYYNNGSSGRIVYAVLSDVDGLKYTKIIKDDGNCVV-LELDPPCKFSIQDV 4257
Query 4198 KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAY 4257
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y
Sbjct 4258 KGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTY 4317
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK 4317
DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+
Sbjct 4318 LDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVD 4377
Query 4318 GFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC
Sbjct 4378 GLCKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSC 4419
Score = 82.8 bits (203), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1328 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1387
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1388 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1447
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1448 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1484
Score = 80.5 bits (197), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 90/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G+F + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGLFVVSQANFNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSF---TNGAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDQAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L D + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKDHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 44.7 bits (104), Expect = 0.027, Method: Compositional matrix adjust.
Identities = 38/137 (28%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1117 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1176
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++AV + G +
Sbjct 1177 KAIVLPQGGYVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDAVFFYGDI--- 1229
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1230 -----VSHVCKCGHNMT 1241
>sp|P0C6X4|R1AB_CVHN5 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N5) OX=443241 GN=rep PE=3 SV=1
Length=7132
Score = 1809 bits (4685), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1062/2868 (37%), Positives = 1572/2868 (55%), Gaps = 118/2868 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1600 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1659
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1660 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1718
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1719 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1778
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1779 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1835
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1836 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1893
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1894 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1952
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL + LN GF E VT +P GDVV Y +
Sbjct 1953 DGVYTNFKLVGHD--ICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2010
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2011 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2055
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2056 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2115
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2116 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2174
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2175 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2228
Query 2196 KSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGV----------------LLSNFGAPSY 2239
+ F K F + + L + + + F + + + FG +
Sbjct 2229 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2288
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2289 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2344
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2345 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2404
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2405 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2464
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2465 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2524
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + S D + +A
Sbjct 2525 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVE--SDADRANFLNAV 2582
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2583 VFYAQSLYRPILLVDKKLITTACNGISVTQIMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2642
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2643 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2702
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK N+S IW + + L+ L+ +++ A K
Sbjct 2703 LKSDNIVAADLGVLIQNGAKHVQGNVAKVANISCIWFIDAFNQLTADLQHKLKKACVKTG 2762
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2763 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2819
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2820 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2879
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2880 AVMDEDIGSTMFNVPTKVLR-YGFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2938
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2939 SSLCTMFKRGDGTPHPYCYTDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 2998
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 2999 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFSSL 3058
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3059 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3118
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3119 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3178
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3179 WLFS-YCRK-IGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3234
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3235 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3294
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3295 SKIEPCLVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3354
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3355 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3414
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3415 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFNGNFYGPYRDAQV 3474
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3475 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3532
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3533 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3591
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3592 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3649
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3650 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSHFVPAVNFTYVYE-VFYGCILCV 3708
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3709 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3764
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3765 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3824
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3825 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3884
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL S AVD
Sbjct 3885 VVLLNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFSNPAAVDTKC 3944
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3945 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4004
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4005 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4064
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPL+ IP A L +++PD + D TYA ++W IQ V
Sbjct 4065 QALNSILDNAVKGCVPLSAIPALAANTLTIIIPDKQVFDKVVDNVYVTYAGSVWHIQTVQ 4124
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGT-- 4135
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4125 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDI 4180
Query 4136 ---TQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRF 4192
T C YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4181 NCNIPTQC-------YYNNVSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKF 4232
Query 4193 VTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVD 4252
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VD
Sbjct 4233 SIQDVKGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVD 4292
Query 4253 PAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHID 4312
P K Y DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++
Sbjct 4293 PKKTYLDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVE 4352
Query 4313 HPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
HP+ G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC
Sbjct 4353 HPDVDGICKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSC 4399
Score = 82.8 bits (203), Expect = 8e-14, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1308 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1367
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1368 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1427
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1428 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1464
Score = 78.6 bits (192), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 89/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G F + + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGFFVVSQANLNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSF---TNGAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDHAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L + + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 45.1 bits (105), Expect = 0.026, Method: Compositional matrix adjust.
Identities = 38/137 (28%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1097 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1156
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++AV + G +
Sbjct 1157 KAIVLPQGGYVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDAVFFYGDI--- 1209
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1210 -----VSHVCKCGHNMT 1221
>sp|P0C6X2|R1AB_CVHN1 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N1) OX=443239 GN=rep PE=3 SV=1
Length=7182
Score = 1806 bits (4678), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1060/2863 (37%), Positives = 1572/2863 (55%), Gaps = 108/2863 (4%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1650 KKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENLS 1709
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1710 LADISAVQSSFGFDQQQLLAYYNFLT-VCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQH 1768
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1769 INLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGAI 1828
Query 1723 RVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC-GRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C GR + + F
Sbjct 1829 CELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAGR--IVHCTKLNVPF 1885
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1886 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1943
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1944 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 2002
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPAS-RELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL + LN GF E VT +P GDVV Y +
Sbjct 2003 DGVYTNFKLVGHD--ICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2060
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2061 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2105
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2106 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2165
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2166 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2224
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2225 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2278
Query 2196 KSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGV----------------LLSNFGAPSY 2239
+ F K F + + L + + + F + + + FG +
Sbjct 2279 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2338
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKL--DLTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2339 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2394
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2395 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2454
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2455 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2514
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2515 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2574
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V +S D + +A
Sbjct 2575 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVV--VESDADRANFLNAV 2632
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2633 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2692
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2693 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2752
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2753 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDAFNQLTADLQHKLKKACVKTG 2812
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2813 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFVSLICFI---LLWALLPTYSVY 2869
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS--YKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ GS Y N CP+V
Sbjct 2870 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2929
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2930 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2988
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2989 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3048
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3049 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3108
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3109 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLMLFV 3168
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3169 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3228
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ Y RK + N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3229 WLFS-YCRK-IGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3284
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3285 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3344
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC++ +M P+Y LL R + F + +
Sbjct 3345 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMNEPDYSALLCRVTLGDFTIMS 3404
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3405 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGNVKPGETFTVLAAYNGRPQGAFHVTM 3464
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3465 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3524
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ + DFN+ AM + + D V L
Sbjct 3525 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLV--L 3582
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3583 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3641
Query 3551 KIVKGTHHWMLL-TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK 3609
+ +K T +W+L+ TFL S I+ +W++F ++ + TL ++ + MLLVKHK
Sbjct 3642 RFIKETIYWILISTFLFS-CIISAFVKWTIFMYI-NTHMIGVTLCVLCFVSFMMLLVKHK 3699
Query 3610 HAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-V 3667
H +L ++++P L T+ Y N +V + WL +++ + + V Y L V
Sbjct 3700 HFYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSYFVPAVNFTYVYE-VFYGCILCV 3758
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTT 3727
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ T + TT
Sbjct 3759 FAIFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLFITAFLGTYTW----TT 3814
Query 3728 IMFLARA-IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
I+ LA A IV + F ++ I+L Y F+GY CY+G F LLN FR+ +G
Sbjct 3815 ILSLAIAKIVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMG 3874
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
VY+Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +
Sbjct 3875 VYNYKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCAN 3934
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD--- 3903
VVLL+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3935 VVLLNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKC 3994
Query 3904 ---INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKK 3959
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K
Sbjct 3995 LASIDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEK 4054
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN
Sbjct 4055 ACNIAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDN 4114
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
ALN+I++NA GCVPL+ IP A L +V+PD + D TYA ++W IQ V
Sbjct 4115 QALNSILDNAVKGCVPLSAIPALAANTLTIVIPDKQVFDKVVDNVYVTYAGSVWHIQTVQ 4174
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVK--LQNNELSPVALRQMSCAAGTTQ 4137
DAD QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4175 DADGINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDM 4230
Query 4138 TACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTP 4197
+ YYNN GR V A+LSD LK+ + K DG + EL+PPC+F
Sbjct 4231 NC--NIPTQCYYNNGSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDV 4287
Query 4198 KGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAY 4257
KG K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y
Sbjct 4288 KGLKIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTY 4347
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPK 4317
DY+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+
Sbjct 4348 LDYIQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVD 4407
Query 4318 GFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
G C L+GK+VQ+P DP+ + L + VC VCG W+ CSC
Sbjct 4408 GICKLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSC 4449
Score = 82.8 bits (203), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 55/157 (35%), Positives = 80/157 (51%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1358 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1417
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + + LL AY++ N+ D L+ L+
Sbjct 1418 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1477
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1478 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1514
Score = 78.6 bits (192), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 89/362 (25%), Positives = 158/362 (44%), Gaps = 48/362 (13%)
Query 616 LLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCV 675
LLGTT+ + + W L A W +L L+ G+F + + + I D
Sbjct 615 LLGTTL--VNKMVNWFNTMLDASAP--ATGW-LLYQLLNGLFVVSQANFNFVA-LIPDYA 668
Query 676 KCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLYRQCIRGKEQ 726
K ++ ++ ++ VT+ K L+++N +G F S GL I G
Sbjct 669 KILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGL----IPG--- 721
Query 727 LQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTN---GAIVGTP 782
++P A +++ F EG +E V++++ +E +++ + S+ V
Sbjct 722 --FVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYCQPPKSVEKI 772
Query 783 VCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGG--APIKG--VTFGED-TVWEVQGY 837
++ + + + DK P ++ N+ L P G V F E V E+
Sbjct 773 CIIDNMYMGKCGDK-----FFPIVMNDKNICLLDQAWRFPCAGRKVNFNEKPVVMEIPSL 827
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD---LLTNM 894
V++ F+LD D +L + CS + VE G V +F VV +A+ L + + +
Sbjct 828 MTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHPVVGYQV 887
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E +
Sbjct 888 RAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVEDTINDD 947
Query 955 DD 956
+D
Sbjct 948 ED 949
Score = 43.5 bits (101), Expect = 0.066, Method: Compositional matrix adjust.
Identities = 37/137 (27%), Positives = 60/137 (44%), Gaps = 14/137 (10%)
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
+V GL S NC+L SVLL +Q+L KF A++ + + G +F +L
Sbjct 1147 KVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIP 1206
Query 1697 KTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
K + + G V + L ++ + N C CG + L G++A+ + G +
Sbjct 1207 KAIVLPQGGFVADFAYWFLNQFDINAYA---NWCCLKCG-FSFDLNGLDALFFYGDI--- 1259
Query 1755 NLKTGVSIPCVCGRDAT 1771
VS C CG + T
Sbjct 1260 -----VSHVCKCGHNMT 1271
>sp|P0C6F6|R1A_BC512 Replicase polyprotein 1a OS=Bat coronavirus
512/2005 OX=693999 GN=1a PE=3 SV=1
Length=4128
Score = 1209 bits (3129), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 777/2257 (34%), Positives = 1211/2257 (54%), Gaps = 147/2257 (7%)
Query 2148 YVFTLLFQLCTFTKSTNSRIRASLPT---TIAKNSVKSVAKLCLDAGINYVKSPKFSKL- 2203
Y+F+LL K + ++ A +P I K SVK NY F +L
Sbjct 1984 YLFSLLAICFRALKKRDMKVMAGVPERTGIILKRSVK----------YNYKALKFFFRLK 2033
Query 2204 FTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSF 2263
F L S+ L +L + F + + G P C + Y NS+ D+C G+
Sbjct 2034 FQYIKVFLKFSLVLYTLYALMFMF-IRFTPVGTP-ICKRYTDGYANST-FDKNDYC-GNV 2089
Query 2264 PCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAI 2323
C ICL G + L + I + L IL L +++ ++F FF +G++
Sbjct 2090 LCKICLYGYEELSDFTHTRVIWQHLKD-PLIGNILPLF--YLVFLIIFGGFFVRIGITYF 2146
Query 2324 MQVFFGY--FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGC 2381
+ + A + N WL+ + P ++M + + I H++ GC
Sbjct 2147 IMQYINAAGVALGYQDNVWLL-------HLLPFNSMGNIIVVAFIVTRILLFLKHVLFGC 2199
Query 2382 TSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTF 2441
+C+ C K + TRV TI+ G+ +SFYV ANGG+ FCK HN+ C++CD++ G TF
Sbjct 2200 DKPSCIACSKSAKLTRVPLQTILQGVTKSFYVNANGGKKFCKKHNFFCVDCDSYGYGCTF 2259
Query 2442 ISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNL 2501
I+D +A +LS K + PT ++ I+D V NG +LY K + +
Sbjct 2260 INDVIAPELSNVTKLNVIPTGPATIIIDKVEFSNGFYYLYSGSTFWKYNFDITEAKYACK 2319
Query 2502 DNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDST 2561
D L+ N + + +VF+ S + + K+A VY+SQL+C+PI L+D AL++ + +
Sbjct 2320 DVLKNCN----ILTDFVVFN-NSGSNVTQVKNACVYFSQLLCKPIKLVDSALLASL--NV 2372
Query 2562 EVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDT 2621
+ S + A+V+ S +F + + + R+ + +
Sbjct 2373 DFSANLHKAFVEVLSNSFGKDLSNCSNM----------------------NECRESLGLS 2410
Query 2622 DVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTPRDLGACIDCNARHINAQV 2680
DV ++ + +H D+ ++ S NN +++Y K E + D+ C+ A+ +N V
Sbjct 2411 DVPEEEFSAAVSEAHRYDVLISDVSFNNLIVSYAKPEEKLAVHDIANCMRVGAKVVNHNV 2470
Query 2681 AKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG 2740
NV ++W KD+++LSE+ RK I K I F LT R + + T ++ K G
Sbjct 2471 LTKDNVPVVWLAKDFIALSEEARKYIVRTTKTKGINFMLTFNDRRMHLTIPTISVANKKG 2530
Query 2741 KIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEI-IGYKAIQDGVTRDIIS 2799
+ + F + + L L+ + + L T++ +K I++GV +
Sbjct 2531 AGLPSLFTRLY--SFFWHLCVLIVVLFVATSLLDFSAQVTSDTQYDFKYIENGVLKVFEK 2588
Query 2800 TDDCFANKHAGFDAWFSQRGGSY-KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDF 2858
DC N F+ W + + GS N + CP+V + E+ +I PG+P V + G
Sbjct 2589 PLDCVHNAFVNFNEWHNAKFGSIPTNSRRCPIVVGT-SDEVRYI-PGVPAGVF--LYGKS 2644
Query 2859 LHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEG 2918
L F +C+ L + +C+ + CT G+ V YCY +++
Sbjct 2645 LIFAMSTIFGTSGLCFDDRGLTD-----PDSCIFNSACTTLSGIGGRNV-YCYREGVVDN 2698
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLST 2977
+ YS L P + Y LMDG+ I P G +R + T YCR G C S+ G+C+
Sbjct 2699 AKLYSSLLPHSYYRLMDGNHIVLPEIITRGFGIRTIKTQAMTYCRTGECIDSQAGVCVGL 2758
Query 2978 SGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCA 3037
+V + S CG +L+ N+ + +S ++ ++A A
Sbjct 2759 DRFFVYSKT---PGSDYVCGTGFFSLLFNVIGMFSNSIPVTVMSGQILLNCVVAFTAVMA 2815
Query 3038 AYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYL-YLTFYF--T 3094
+ F KF+R+FG+ + V +S + +V S++ S+ L Y T YF T
Sbjct 2816 CFAFTKFKRLFGDMSFGV--------LSVGLCTVVNNLSYVVTQNSIGMLAYATLYFLCT 2867
Query 3095 NDV--SFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV---MFNGVTF 3149
V S++ H+ + + + P+W+ Y+ C L+ F N + +V +F G F
Sbjct 2868 KGVRYSWVWHVGFAISYCFLAPWWVVLAYLICALLE----FLPNLFKLKVSTQLFEGDKF 2923
Query 3150 -STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAAC 3208
+FE AA TF+L+ Y KL + + + +Y A YN+YKY+SG+ YR A
Sbjct 2924 VGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQYCASYNRYKYYSGSASEADYRLACF 2981
Query 3209 CHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLN 3268
HLAKA++DF+N D LY PP S S LQ+G RKMA PSG VEGC+V+V+ G TLN
Sbjct 2982 AHLAKAMSDFANDHMDKLYTPPTVSYNST-LQAGLRKMAQPSGIVEGCIVRVSYGNLTLN 3040
Query 3269 GLWLDDTVYCPRHVICT-AEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLL 3327
GLWL DTV CPRHVI + ++++ ++ L+R H+F + +GN+ L VI SM+ LL
Sbjct 3041 GLWLGDTVICPRHVIASNTTNVIDYDHAMSLVRL--HNFSISSGNMFLGVISASMRGTLL 3098
Query 3328 RLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGS 3387
+KV+ SN TP Y + ++PG +F++LACY+GS +GVY MR N+TI+GSF++G+CGS
Sbjct 3099 HIKVNQSNVNTPNYTYKVLKPGDSFNILACYDGSAAGVYGVNMRTNYTIRGSFISGACGS 3158
Query 3388 VGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAW 3447
G+NI+ V FCYMHH+EL +G H G+D++G YG + D+ T Q G +T NV +W
Sbjct 3159 PGYNINNGVVEFCYMHHLELGSGCHVGSDMDGTMYGKYEDQPTLQIEGASNLVTENVCSW 3218
Query 3448 LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAA 3507
LY A+INGDRW+L+ + ++ +N A++ L +VD L A+TG+ V + A+
Sbjct 3219 LYGALINGDRWWLSSVSVGVDTYNEWALRNGMTALK--NVDCFSLLVAKTGVDVGRLLAS 3276
Query 3508 LKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKGTHHWMLLTFLT 3566
+++L N G++ILG T L DEFT +VV+Q GVT Q GK + + L FL
Sbjct 3277 IQKLHGN-FGGKSILGCTSLCDEFTLSEVVKQMYGVTLQSGKVSRAFRNASIVCCLLFL- 3334
Query 3567 SLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAY 3626
L + S F++ P L I+ ++ MLLVKHK FL L+LLPSL V+
Sbjct 3335 ---FLSEMLNHSKLFWINPGYITPVFLAIIVASSALMLLVKHKLLFLQLYLLPSLCIVSG 3391
Query 3627 FNMV--YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARR 3684
+N+ Y ++++ + G+ + + + ++ L T R + +
Sbjct 3392 YNIFKDYHFYTYMLEEFDY----KVPFGGFNVTGVLNISLCCFVMGLHTFR--FLQTPNK 3445
Query 3685 VWT-LMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYY 3743
+++ ++ V+T++Y YY + + L+++ S + T F+ A +
Sbjct 3446 IFSYVVAVLTVLYTYYY------STDVLGLILTSMSGF----TNYWFIGTATYKLATYVL 3495
Query 3744 P--LLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMN 3801
P L + + ++ ++ +Y LGYC C Y+G +NR+ +LTLG Y++ VS EF+YM
Sbjct 3496 PHTSLLDSFDAIKAVVFLYLLLGYCNCVYYGSLYWINRFCKLTLGCYEFKVSAAEFKYMV 3555
Query 3802 SQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESS 3861
+ GL P DA L++KL+G+GG+ IK+++VQSK++D+KCT+VVLL L + + ++
Sbjct 3556 ANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQSKLTDLKCTNVVLLGCLSNMNIAAN 3615
Query 3862 SKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAI 3921
S+ WA CV LHN I L D A E +++LL+ LS A ++ L + ++ + LQ++
Sbjct 3616 SREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFGVDELLDSYFNDSSVLQSV 3675
Query 3922 ASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM 3981
A+ + +LPSY AY TA+++YE A+ANG ++K+L+ ++NVAKSEFDR+A+ QRKL++M
Sbjct 3676 AATYVNLPSYLAYETARQSYEDALANGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRM 3735
Query 3982 ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPL 4041
A+QA +QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I++ A+DG VPL+IIP
Sbjct 3736 AEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILSLAKDGVVPLSIIPA 3795
Query 4042 TTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAW 4101
+A KL +VV D +Y YA +W + + D D K V E+ N +LAW
Sbjct 3796 VSATKLNIVVSDIESYSKIQREGCVHYAGVIWSVVDIKDNDGKPVHAKEVVTSNVESLAW 3855
Query 4102 PLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLAL 4161
PL + R +KLQNNE+ P ++Q A + D NAL Y+N G F+ A
Sbjct 3856 PLFLNCER---IIKLQNNEIIPSKIKQRPIKA-EGEGVVADGNAL--YSNEGGRTFMYAF 3909
Query 4162 LSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLG 4221
+SD DLK ++ G+ I ELEPPC+F+ + P GP VKYLYF++ LNNL RG VLG
Sbjct 3910 ISDKPDLKVVKWEFDGGSNAI--ELEPPCKFLVEAPSGPVVKYLYFVRNLNNLRRGAVLG 3967
Query 4222 SLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGT 4281
+ ATVRLQAG TE NS++L+ CAFAVDP K Y D + SG +P+ NCVKML +G
Sbjct 3968 FIGATVRLQAGKQTEQATNSSLLTLCAFAVDPPKTYLDAVKSGHRPVGNCVKMLANGSGN 4027
Query 4282 GQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFT 4341
GQAIT EA+ +Q+S+GGAS CLYCR H++HP+ GFC L+GKYVQ+P DP+ F
Sbjct 4028 GQAITNGVEASTNQDSYGGASVCLYCRAHVEHPDMDGFCKLRGKYVQVPLGTL-DPIRFV 4086
Query 4342 LRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
L NTVC VCG W+ GC+CD+ ++QS D S +LN
Sbjct 4087 LENTVCKVCGCWQANGCTCDR---AVIQSVD-SGYLN 4119
Score = 69.7 bits (169), Expect = 9e-10, Method: Compositional matrix adjust.
Identities = 46/123 (37%), Positives = 60/123 (49%), Gaps = 2/123 (2%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
S N +VNAAN L HGGG+A AL+ T G +Q S+ Y+ NG + VG L+
Sbjct 1317 SVNHDFVVNAANEQLSHGGGIAKALDDLTKGELQVLSNQYVSRNGSIKVGSGVLIKCKE- 1375
Query 1089 AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVR 1148
L+VVGP L KA F + + L PLLS GIF +SL + V
Sbjct 1376 -HSILNVVGPRKGKHAAELLTKAYTFVFKQKGVPLMPLLSVGIFKVPITESLAAFLACVG 1434
Query 1149 TQV 1151
+V
Sbjct 1435 DRV 1437
Score = 66.6 bits (161), Expect = 7e-09, Method: Compositional matrix adjust.
Identities = 78/317 (25%), Positives = 125/317 (39%), Gaps = 29/317 (9%)
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
+L E K ++V T D + HT + S TYGQQ G ++ VT +KP + + V
Sbjct 1634 TLFEAKPVQVVVTQDQRSFHTVELSTSQTYGQQLGDCVVEDKKVTNLKPVSKDKVVS--V 1691
Query 1598 LPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLS 1654
+P+ D + F +HTLD + M ++ V G ++ +DNNC+++
Sbjct 1692 VPNVDWDKHYGFVDAGIFHTLDHT-----MFVFDNN------VVNGKRVLRTSDNNCWIN 1740
Query 1655 SVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQ 1714
+V L LQ KF LQ+ + GD A F + + GE D T+ + +
Sbjct 1741 AVCLQLQFANAKFKPKGLQQLWESYCTGDVAMFVHWLYWITGVEKGEPSDAENTLNIISR 1800
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQY 1773
+ + +L C +T + V+ ++ LK G+ CV G
Sbjct 1801 FLKPQGSVEMLRATSTTCDGTCST----KRVVSTPVVNASVLKVGLDDGNCVHGLPLVDR 1856
Query 1774 LVQQESSFVMMSA---PPAEYKLQQGTFLCANEYT----GNYQCGHYTHITAKETLYRID 1826
+V + ++ + P + L YT GHYT + KE D
Sbjct 1857 VVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGVGHYT-VFDKEAKLMFD 1915
Query 1827 GAHLTKMSEYKGPVTDV 1843
G L PVT V
Sbjct 1916 GDVLKPCDLNVSPVTSV 1932
>sp|P0C6W0|R1AB_BC512 Replicase polyprotein 1ab OS=Bat coronavirus
512/2005 OX=693999 GN=rep PE=3 SV=1
Length=6793
Score = 1209 bits (3128), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 777/2257 (34%), Positives = 1211/2257 (54%), Gaps = 147/2257 (7%)
Query 2148 YVFTLLFQLCTFTKSTNSRIRASLPT---TIAKNSVKSVAKLCLDAGINYVKSPKFSKL- 2203
Y+F+LL K + ++ A +P I K SVK NY F +L
Sbjct 1984 YLFSLLAICFRALKKRDMKVMAGVPERTGIILKRSVK----------YNYKALKFFFRLK 2033
Query 2204 FTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSF 2263
F L S+ L +L + F + + G P C + Y NS+ D+C G+
Sbjct 2034 FQYIKVFLKFSLVLYTLYALMFMF-IRFTPVGTP-ICKRYTDGYANST-FDKNDYC-GNV 2089
Query 2264 PCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAI 2323
C ICL G + L + I + L IL L +++ ++F FF +G++
Sbjct 2090 LCKICLYGYEELSDFTHTRVIWQHLKD-PLIGNILPLF--YLVFLIIFGGFFVRIGITYF 2146
Query 2324 MQVFFGY--FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGC 2381
+ + A + N WL+ + P ++M + + I H++ GC
Sbjct 2147 IMQYINAAGVALGYQDNVWLL-------HLLPFNSMGNIIVVAFIVTRILLFLKHVLFGC 2199
Query 2382 TSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTF 2441
+C+ C K + TRV TI+ G+ +SFYV ANGG+ FCK HN+ C++CD++ G TF
Sbjct 2200 DKPSCIACSKSAKLTRVPLQTILQGVTKSFYVNANGGKKFCKKHNFFCVDCDSYGYGCTF 2259
Query 2442 ISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNL 2501
I+D +A +LS K + PT ++ I+D V NG +LY K + +
Sbjct 2260 INDVIAPELSNVTKLNVIPTGPATIIIDKVEFSNGFYYLYSGSTFWKYNFDITEAKYACK 2319
Query 2502 DNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDST 2561
D L+ N + + +VF+ S + + K+A VY+SQL+C+PI L+D AL++ + +
Sbjct 2320 DVLKNCN----ILTDFVVFN-NSGSNVTQVKNACVYFSQLLCKPIKLVDSALLASL--NV 2372
Query 2562 EVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDT 2621
+ S + A+V+ S +F + + + R+ + +
Sbjct 2373 DFSANLHKAFVEVLSNSFGKDLSNCSNM----------------------NECRESLGLS 2410
Query 2622 DVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTPRDLGACIDCNARHINAQV 2680
DV ++ + +H D+ ++ S NN +++Y K E + D+ C+ A+ +N V
Sbjct 2411 DVPEEEFSAAVSEAHRYDVLISDVSFNNLIVSYAKPEEKLAVHDIANCMRVGAKVVNHNV 2470
Query 2681 AKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG 2740
NV ++W KD+++LSE+ RK I K I F LT R + + T ++ K G
Sbjct 2471 LTKDNVPVVWLAKDFIALSEEARKYIVRTTKTKGINFMLTFNDRRMHLTIPTISVANKKG 2530
Query 2741 KIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEI-IGYKAIQDGVTRDIIS 2799
+ + F + + L L+ + + L T++ +K I++GV +
Sbjct 2531 AGLPSLFTRLY--SFFWHLCVLIVVLFVATSLLDFSAQVTSDTQYDFKYIENGVLKVFEK 2588
Query 2800 TDDCFANKHAGFDAWFSQRGGSY-KNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDF 2858
DC N F+ W + + GS N + CP+V + E+ +I PG+P V + G
Sbjct 2589 PLDCVHNAFVNFNEWHNAKFGSIPTNSRRCPIVVGT-SDEVRYI-PGVPAGVF--LYGKS 2644
Query 2859 LHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEG 2918
L F +C+ L + +C+ + CT G+ V YCY +++
Sbjct 2645 LIFAMSTIFGTSGLCFDDRGLTD-----PDSCIFNSACTTLSGIGGRNV-YCYREGVVDN 2698
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLST 2977
+ YS L P + Y LMDG+ I P G +R + T YCR G C S+ G+C+
Sbjct 2699 AKLYSSLLPHSYYRLMDGNHIVLPEIITRGFGIRTIKTQAMTYCRTGECIDSQAGVCVGL 2758
Query 2978 SGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCA 3037
+V + S CG +L+ N+ + +S ++ ++A A
Sbjct 2759 DRFFVYSKT---PGSDYVCGTGFFSLLFNVIGMFSNSIPVTVMSGQILLNCVVAFTAVMA 2815
Query 3038 AYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYL-YLTFYF--T 3094
+ F KF+R+FG+ + V +S + +V S++ S+ L Y T YF T
Sbjct 2816 CFAFTKFKRLFGDMSFGV--------LSVGLCTVVNNLSYVVTQNSIGMLAYATLYFLCT 2867
Query 3095 NDV--SFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV---MFNGVTF 3149
V S++ H+ + + + P+W+ Y+ C L+ F N + +V +F G F
Sbjct 2868 KGVRYSWVWHVGFAISYCFLAPWWVVLAYLICALLE----FLPNLFKLKVSTQLFEGDKF 2923
Query 3150 -STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAAC 3208
+FE AA TF+L+ Y KL + + + +Y A YN+YKY+SG+ YR A
Sbjct 2924 VGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQYCASYNRYKYYSGSASEADYRLACF 2981
Query 3209 CHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLN 3268
HLAKA++DF+N D LY PP S S LQ+G RKMA PSG VEGC+V+V+ G TLN
Sbjct 2982 AHLAKAMSDFANDHMDKLYTPPTVSYNST-LQAGLRKMAQPSGIVEGCIVRVSYGNLTLN 3040
Query 3269 GLWLDDTVYCPRHVICT-AEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLL 3327
GLWL DTV CPRHVI + ++++ ++ L+R H+F + +GN+ L VI SM+ LL
Sbjct 3041 GLWLGDTVICPRHVIASNTTNVIDYDHAMSLVRL--HNFSISSGNMFLGVISASMRGTLL 3098
Query 3328 RLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGS 3387
+KV+ SN TP Y + ++PG +F++LACY+GS +GVY MR N+TI+GSF++G+CGS
Sbjct 3099 HIKVNQSNVNTPNYTYKVLKPGDSFNILACYDGSAAGVYGVNMRTNYTIRGSFISGACGS 3158
Query 3388 VGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAW 3447
G+NI+ V FCYMHH+EL +G H G+D++G YG + D+ T Q G +T NV +W
Sbjct 3159 PGYNINNGVVEFCYMHHLELGSGCHVGSDMDGTMYGKYEDQPTLQIEGASNLVTENVCSW 3218
Query 3448 LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAA 3507
LY A+INGDRW+L+ + ++ +N A++ L +VD L A+TG+ V + A+
Sbjct 3219 LYGALINGDRWWLSSVSVGVDTYNEWALRNGMTALK--NVDCFSLLVAKTGVDVGRLLAS 3276
Query 3508 LKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKGTHHWMLLTFLT 3566
+++L N G++ILG T L DEFT +VV+Q GVT Q GK + + L FL
Sbjct 3277 IQKLHGN-FGGKSILGCTSLCDEFTLSEVVKQMYGVTLQSGKVSRAFRNASIVCCLLFL- 3334
Query 3567 SLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAY 3626
L + S F++ P L I+ ++ MLLVKHK FL L+LLPSL V+
Sbjct 3335 ---FLSEMLNHSKLFWINPGYITPVFLAIIVASSALMLLVKHKLLFLQLYLLPSLCIVSG 3391
Query 3627 FNMV--YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARR 3684
+N+ Y ++++ + G+ + + + ++ L T R + +
Sbjct 3392 YNIFKDYHFYTYMLEEFDY----KVPFGGFNVTGVLNISLCCFVMGLHTFR--FLQTPNK 3445
Query 3685 VWT-LMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYY 3743
+++ ++ V+T++Y YY + + L+++ S + T F+ A +
Sbjct 3446 IFSYVVAVLTVLYTYYY------STDVLGLILTSMSGF----TNYWFIGTATYKLATYVL 3495
Query 3744 PL--LFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMN 3801
P L + + ++ ++ +Y LGYC C Y+G +NR+ +LTLG Y++ VS EF+YM
Sbjct 3496 PHTSLLDSFDAIKAVVFLYLLLGYCNCVYYGSLYWINRFCKLTLGCYEFKVSAAEFKYMV 3555
Query 3802 SQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESS 3861
+ GL P DA L++KL+G+GG+ IK+++VQSK++D+KCT+VVLL L + + ++
Sbjct 3556 ANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQSKLTDLKCTNVVLLGCLSNMNIAAN 3615
Query 3862 SKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAI 3921
S+ WA CV LHN I L D A E +++LL+ LS A ++ L + ++ + LQ++
Sbjct 3616 SREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFGVDELLDSYFNDSSVLQSV 3675
Query 3922 ASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM 3981
A+ + +LPSY AY TA+++YE A+ANG ++K+L+ ++NVAKSEFDR+A+ QRKL++M
Sbjct 3676 AATYVNLPSYLAYETARQSYEDALANGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRM 3735
Query 3982 ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPL 4041
A+QA +QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I++ A+DG VPL+IIP
Sbjct 3736 AEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILSLAKDGVVPLSIIPA 3795
Query 4042 TTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAW 4101
+A KL +VV D +Y YA +W + + D D K V E+ N +LAW
Sbjct 3796 VSATKLNIVVSDIESYSKIQREGCVHYAGVIWSVVDIKDNDGKPVHAKEVVTSNVESLAW 3855
Query 4102 PLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLAL 4161
PL + R +KLQNNE+ P ++Q A + D NAL Y+N G F+ A
Sbjct 3856 PLFLNCER---IIKLQNNEIIPSKIKQRPIKA-EGEGVVADGNAL--YSNEGGRTFMYAF 3909
Query 4162 LSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLG 4221
+SD DLK ++ G+ I ELEPPC+F+ + P GP VKYLYF++ LNNL RG VLG
Sbjct 3910 ISDKPDLKVVKWEFDGGSNAI--ELEPPCKFLVEAPSGPVVKYLYFVRNLNNLRRGAVLG 3967
Query 4222 SLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGT 4281
+ ATVRLQAG TE NS++L+ CAFAVDP K Y D + SG +P+ NCVKML +G
Sbjct 3968 FIGATVRLQAGKQTEQATNSSLLTLCAFAVDPPKTYLDAVKSGHRPVGNCVKMLANGSGN 4027
Query 4282 GQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFT 4341
GQAIT EA+ +Q+S+GGAS CLYCR H++HP+ GFC L+GKYVQ+P DP+ F
Sbjct 4028 GQAITNGVEASTNQDSYGGASVCLYCRAHVEHPDMDGFCKLRGKYVQVPLGTL-DPIRFV 4086
Query 4342 LRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
L NTVC VCG W+ GC+CD+ ++QS D S +LN
Sbjct 4087 LENTVCKVCGCWQANGCTCDR---AVIQSVD-SGYLN 4119
Score = 70.1 bits (170), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 46/123 (37%), Positives = 60/123 (49%), Gaps = 2/123 (2%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
S N +VNAAN L HGGG+A AL+ T G +Q S+ Y+ NG + VG L+
Sbjct 1317 SVNHDFVVNAANEQLSHGGGIAKALDDLTKGELQVLSNQYVSRNGSIKVGSGVLIKCKE- 1375
Query 1089 AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVR 1148
L+VVGP L KA F + + L PLLS GIF +SL + V
Sbjct 1376 -HSILNVVGPRKGKHAAELLTKAYTFVFKQKGVPLMPLLSVGIFKVPITESLAAFLACVG 1434
Query 1149 TQV 1151
+V
Sbjct 1435 DRV 1437
Score = 66.2 bits (160), Expect = 9e-09, Method: Compositional matrix adjust.
Identities = 77/317 (24%), Positives = 124/317 (39%), Gaps = 29/317 (9%)
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
+L E K ++V T D + HT + S TYGQQ G ++ VT +KP + + V
Sbjct 1634 TLFEAKPVQVVVTQDQRSFHTVELSTSQTYGQQLGDCVVEDKKVTNLKPVSKDKVVS--V 1691
Query 1598 LPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLS 1654
+P+ D + F +HTLD + + +N G ++ +DNNC+++
Sbjct 1692 VPNVDWDKHYGFVDAGIFHTLDHTMFVFDNNVVN-----------GKRVLRTSDNNCWIN 1740
Query 1655 SVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQ 1714
+V L LQ KF LQ+ + GD A F + + GE D T+ + +
Sbjct 1741 AVCLQLQFANAKFKPKGLQQLWESYCTGDVAMFVHWLYWITGVEKGEPSDAENTLNIISR 1800
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQY 1773
+ + +L C +T + V+ ++ LK G+ CV G
Sbjct 1801 FLKPQGSVEMLRATSTTCDGTCST----KRVVSTPVVNASVLKVGLDDGNCVHGLPLVDR 1856
Query 1774 LVQQESSFVMMSA---PPAEYKLQQGTFLCANEYT----GNYQCGHYTHITAKETLYRID 1826
+V + ++ + P + L YT GHYT + KE D
Sbjct 1857 VVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGVGHYT-VFDKEAKLMFD 1915
Query 1827 GAHLTKMSEYKGPVTDV 1843
G L PVT V
Sbjct 1916 GDVLKPCDLNVSPVTSV 1932
>sp|P0C6V6|R1A_PEDV7 Replicase polyprotein 1a OS=Porcine epidemic
diarrhea virus (strain CV777) OX=229032 GN=1a PE=1 SV=1
Length=4117
Score = 1192 bits (3084), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 760/2187 (35%), Positives = 1154/2187 (53%), Gaps = 165/2187 (8%)
Query 2235 GAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETI---------- 2284
G+P C+ V Y NSS ++C S C +CL G L + + +
Sbjct 2050 GSP-VCDDVVAGYANSS-FDKNEYCN-SVICKVCLYGYQELSDFSHTQVVWQHLRDPLIG 2106
Query 2285 QVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWF 2344
V Y L I G +V A L+ F YL L VF G S +WF
Sbjct 2107 NVMPFFYLAFLAIFG--GVYVKAITLYFIFQYLNSLG----VFLGLQQS--------IWF 2152
Query 2345 IISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIV 2404
+ Q+ P + F + H+ GC ++C+ C K R RV TI
Sbjct 2153 L----QLVPFDVFGDEIVVFFIVTRVLMFIKHVCLGCDKASCVACSKSARLKRVPVQTIF 2208
Query 2405 NGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQS 2464
G +SFYV+ANGG FCK HN+ CLNCD++ G TFI+D +A ++ K + PT +
Sbjct 2209 QGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGCTFINDVIATEVGNVVKLNVQPTGPA 2268
Query 2465 SYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKS 2524
+ ++D V NG +LY K S + + L+ S+ + IVF+
Sbjct 2269 TILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYTCKEALK----NCSIITDFIVFNNNG 2324
Query 2525 KCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPME 2584
+ + K+A VY+SQ++C+P+ L+D AL++ + S + + A+V S +F +
Sbjct 2325 S-NVNQVKNACVYFSQMLCKPVKLVDSALLASL--SVDFGASLHSAFVSVLSNSFGKDLS 2381
Query 2585 KLKALVATAHSELAKGVALDGV-LSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVT 2643
+ + + D V L TF +A + +H D+ +T
Sbjct 2382 SCNDM-----QDCKSTLGFDDVPLDTFNAAVAE------------------AHRYDVLLT 2418
Query 2644 GDSCNNFMLTYNKVENMTP-RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
S NNF +Y K E P D+ C+ A+ +N V ++ ++W V+D+++LSE+
Sbjct 2419 DMSFNNFTTSYAKPEEKFPVHDIATCMRVGAKIVNHNVLVKDSIPVVWLVRDFIALSEET 2478
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
RK I K I F LT R + T I+ K G + + K+ LC+
Sbjct 2479 RKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIANKKGAGLPSFSKVKKFFWFLCL---- 2534
Query 2763 VCYIVMPVHTLSIHDGYT----NEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR 2818
+IV LS D T + +K I+ G + + C N FD W +
Sbjct 2535 --FIVAAFFALSFLDFSTQVSSDSDYDFKYIESGQLKTFDNPLSCVHNVFINFDQWHDAK 2592
Query 2819 GG-SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPS 2877
G + N+ SCP+V + + VPG+P V A G L F +C+ S
Sbjct 2593 FGFTPVNNPSCPIVVGV--SDEARTVPGIPAGVYLA--GKTLVFAINTIFGTSGLCFDAS 2648
Query 2878 KLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS 2937
+ + AC+ + CT +G YCY L+EG+ YSEL P + Y ++DG+
Sbjct 2649 GVAD-----KGACIFNSACTTLS-GLGGTAVYCYKNGLVEGAKLYSELAPHSYYKMVDGN 2702
Query 2938 IIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFC 2996
+ P G +R + T YCR G C +S G+C +V N E + S C
Sbjct 2703 AVSLPEIISRGFGIRTIRTKAMTYCRVGQCVQSAEGVCFGADRFFVYNAE---SGSDFVC 2759
Query 2997 GVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYN-HVV 3055
G L+ N+ + + V +S ++ IIA + + F KF+R+FG+ + V
Sbjct 2760 GTGLFTLLMNVISVFSKTVPVTVLSGQILFNCIIAFVAVAVCFLFTKFKRMFGDMSVGVF 2819
Query 3056 AANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYF--TNDVSFLA--HLQWFAMFSP 3111
A L + + + L Y T YF T V ++ HL + +
Sbjct 2820 TVGACTLLNNVSYIVTQNTLGMLG--------YATLYFLCTKGVRYMWIWHLGFLISYIL 2871
Query 3112 IVPFWITAIYVFCISLKHCHWFFNNYLRKRV---MFNGVTF-STFEEAALCTFLLNKEMY 3167
I P+W+ +Y F + F N + +V +F G F +FE AA TF+L+ Y
Sbjct 2872 IAPWWVLMVYAFSAIFE----FMPNLFKLKVSTQLFEGDKFVGSFENAAAGTFVLDMHAY 2927
Query 3168 LKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLY 3227
+L + + + +Y + YNKYKY+SG+ YR A HLAKA+ D++++ D LY
Sbjct 2928 ERLANS--ISTEKLRQYASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYASNHNDTLY 2985
Query 3228 QPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAE 3287
PP S S LQ+G RKMA PSG VE C+V+V G LNGLWL D V CPRHVI ++
Sbjct 2986 TPPTVSYNST-LQAGLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRHVIASST 3044
Query 3288 -DMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRI 3346
++ +Y ++R H+F + +GNV L V+ +M+ LL++KV+ +N TPKY + +
Sbjct 3045 TSTIDYDYALSVLRL--HNFSISSGNVFLGVVSATMRGALLQIKVNQNNVHTPKYTYRTV 3102
Query 3347 QPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHME 3406
+PG++F++LACY+G+ +GVY MR N+TI+GSF+NG+CGS G+NI+ V FCY+H +E
Sbjct 3103 RPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNINNGTVEFCYLHQLE 3162
Query 3407 LPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTT 3466
L +G H G+DL+G YG + D+ T Q G + T NVLA+LYAA+ING W+L+
Sbjct 3163 LGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTENVLAFLYAALINGSTWWLSSSRIA 3222
Query 3467 LNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTI 3526
++ FN A+ T + D L+A+TG+ V + A+++ L +N G+ ILG T
Sbjct 3223 VDRFNEWAVHNGMT--TVGNTDCFSILAAKTGVDVQRLLASIQSLHKN-FGGKQILGHTS 3279
Query 3527 LEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWML----LTFLTSLLILVQSTQWSLFFF 3582
L DEFT +VVRQ GV QG + + + + +L LTF S L+ ++ FF+
Sbjct 3280 LTDEFTTGEVVRQMYGVNLQGGY--VSRACRNVLLVGSFLTFFWSELV-----SYTKFFW 3332
Query 3583 VYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMT 3642
V P + +++ M +KHK F +FL+P+L + N+ + +
Sbjct 3333 VNPGYVTPMFACLSLLSSLLMFTLKHKTLFFQVFLIPALIVTSCINLAF-------DVEV 3385
Query 3643 WLELAD-----TSLSGYRLKDCVMYASALVLLILMTART--VYDDAARRVWTLMNVITLV 3695
+ LA+ SL G+ + V V+ IL T ++ A V ++ ++T
Sbjct 3386 YNYLAEHFDYHVSLMGFNAQGLVNIFVCFVVTILHGTYTWRFFNTPASSVTYVVALLTAA 3445
Query 3696 YKVYYG-NALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQ 3754
Y +Y + L A++++A SVT N+ V + + + V++ + + + I G+ ++
Sbjct 3446 YNYFYASDILSCAMTLFA---SVTGNW--FVGAVCY--KVAVYMALRFPTFVAIFGD-IK 3497
Query 3755 CIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDA 3814
+M Y LGY CC++G+ NR+F++++GVYDY VS EF+YM + GL P ++D+
Sbjct 3498 SVMFCYLVLGYFTCCFYGILYWFNRFFKVSVGVYDYTVSAAEFKYMVANGLRAPTGTLDS 3557
Query 3815 FKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHND 3874
L+ KL+GIGG+ IK+++VQSK++D+KC++VVLL L + V ++S WA CV LHN
Sbjct 3558 LLLSAKLIGIGGERNIKISSVQSKLTDIKCSNVVLLGCLSSMNVSANSTEWAYCVDLHNK 3617
Query 3875 ILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAY 3934
I L D +A E +++LL+ LS A ++ L E ++ + LQ++AS + LPSY Y
Sbjct 3618 INLCNDPEKAQEMLLALLAFFLSKNSAFGLDDLLESYFNDNSMLQSVASTYVGLPSYVIY 3677
Query 3935 ATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQAR 3994
A++ YE AV NG ++K+L+ ++NVAKSEFDR+A+ QRKL++MA+QA QMYK+AR
Sbjct 3678 ENARQQYEDAVNNGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAAAQMYKEAR 3737
Query 3995 SEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDY 4054
+ ++++KV SAM ++LF MLR+LD +++ I+N A+DG VPL++IP +A KL +V D
Sbjct 3738 AVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVPLSVIPAVSATKLNIVTSDI 3797
Query 4055 GTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAV 4114
+Y YA +W I + D D K+V + E+ N+ +L+WPL++ R V
Sbjct 3798 DSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQNAESLSWPLVLGCER---IV 3854
Query 4115 KLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFP 4174
KLQNNE+ P L+Q S A A YNN G F+ A +SD DL+ ++
Sbjct 3855 KLQNNEIIPGKLKQRSIKAEGDGIV---GEGKALYNNEGGRTFMYAFISDKPDLRVVKWE 3911
Query 4175 KSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNA 4234
G TI ELEPP +F+ D+P G ++KYLYF++ LN L RG VLG + ATVRLQAG
Sbjct 3912 FDGGCNTI--ELEPPRKFLVDSPNGAQIKYLYFVRNLNTLRRGAVLGYIGATVRLQAGKQ 3969
Query 4235 TEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMD 4294
TE NS++L+ CAFAVDPAK Y D + SG +P+ NCVKML +G GQA+T EA+ +
Sbjct 3970 TEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTNGVEASTN 4029
Query 4295 QESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWK 4354
Q+S+GGAS CLYCR H++HP+ GFC LKGKYVQ+P DP+ F L N VC VCG W
Sbjct 4030 QDSYGGASVCLYCRAHVEHPSMDGFCRLKGKYVQVPLGTV-DPIRFVLENDVCKVCGCWL 4088
Query 4355 GYGCSCDQLREPLMQSADASTFLNGFA 4381
GC+CD+ +MQS D + +LN +
Sbjct 4089 SNGCTCDR---SIMQSTDMA-YLNEYG 4111
Score = 87.4 bits (215), Expect = 4e-15, Method: Compositional matrix adjust.
Identities = 86/282 (30%), Positives = 133/282 (47%), Gaps = 29/282 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNAAN L HGGG+A A++ T G +QK S+DYIK +GP+ VG +L L K +
Sbjct 1317 VVNAANEKLSHGGGIAKAIDVYTKGMLQKCSNDYIKAHGPIKVGRGVMLEA--LGLKVFN 1374
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGA---KPLQSLQVCVQTVRTQV 1151
VVGP L+KA F + + L PL+S GIF + L + CV +
Sbjct 1375 VVGPRKGKHAPELLVKAYKSVFANSGVALTPLISVGIFSVPLEESLSAFLACVGDRHCKC 1434
Query 1152 YIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPV--DVKP-KI 1208
+ DK + ++ Y+D L V+A +E +T + + + V QKPV + +P +I
Sbjct 1435 F-CYGDKE--REAIIKYMDGL---VDAIFKEALVDTTPVQEDVQQVSQKPVLPNFEPFRI 1488
Query 1209 KA------CIDEVTTTLEETKFL--TNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
+ C E +L K + TN L F + GK +D + E ++ +K
Sbjct 1489 EGAHAFYECNPEGLMSLGADKLVLFTNSNLDFCSV-GKCLNDVTSGALLEAINVFKKSNK 1547
Query 1261 YM-VGDVITSG-----DITCVVIPSKKAGGTTEMLSRALKKV 1296
+ G+ +T IT VV+P + +RA+ KV
Sbjct 1548 TVPAGNCVTLDCANMISITMVVLPFDGDANYDKNYARAVVKV 1589
Score = 51.6 bits (122), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 82/327 (25%), Positives = 131/327 (40%), Gaps = 37/327 (11%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K++ + T D ++ V+ + TYGQQ GP ++ VT KP V V+P+ +
Sbjct 1631 KSVVIKVTEDTRSVKAVKVESTATYGQQIGPCLVNDTVVTDNKPVVADVVAK--VVPNAN 1688
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQ--VGGLTSIKWADNNCYLSSVLLAL 1660
++ ++ D++ G + L+HT + FP V G IK DNNC+++ L L
Sbjct 1689 ------WDSHYGFDKA--GEF-HMLDHTG-FTFPSEVVNGRRVIKTTDNNCWVNVTCLQL 1738
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQH---AN 1717
Q +F + LQ + GD A F + + G+ D + L ++ A
Sbjct 1739 QFARFRFKSAGLQAMWESYCTGDVAMFVHWLYWLTGVDKGQPSDSENALNMLSKYIVPAG 1798
Query 1718 LESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDAT-QYLV 1775
+ +RV + C C ++ T V A + LK GV C G + + +V
Sbjct 1799 SVTIERVTHDGC-CCSKRVVTAPVVNASV---------LKLGVEDGLCPHGLNYIGKVVV 1848
Query 1776 QQESSFVMMSAPPAEYKLQQGTFLCANEYT-----GNYQCGHYTHITAKETLYRIDGAHL 1830
+ ++ V+ P FL YT GN GHYT + DG
Sbjct 1849 VKGTTIVVNVGKPV--VAPSHLFLKGVSYTTFLDNGNGVVGHYTVFDHGTGMVH-DGDAF 1905
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPV 1857
PVT+V E + PV
Sbjct 1906 VPGDLNVSPVTNVVVSEQTAVVIKDPV 1932
Score = 40.4 bits (93), Expect = 0.55, Method: Compositional matrix adjust.
Identities = 31/101 (31%), Positives = 49/101 (49%), Gaps = 8/101 (8%)
Query 1633 WKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALIL 1692
+ F GGL ++ + NNC+++S L+ LQ L + + PA+ E + R G C
Sbjct 1073 FDFVSYGGLKVLRQSHNNCWVTSTLVQLQLLGI-VDDPAM-ELFSAGRVGPMVRKC---Y 1127
Query 1693 AYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCG 1733
+G LGDV + L + +L + K +VVC CG
Sbjct 1128 ESQKAILGSLGDVSACLESLTK--DLHTLKITCSVVCG-CG 1165
>sp|P0C6Y4|R1AB_PEDV7 Replicase polyprotein 1ab OS=Porcine epidemic
diarrhea virus (strain CV777) OX=229032 GN=rep PE=1 SV=1
Length=6781
Score = 1189 bits (3077), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 760/2190 (35%), Positives = 1155/2190 (53%), Gaps = 165/2190 (8%)
Query 2229 VLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETI---- 2284
+ + G+P C+ V Y NSS ++C S C +CL G L + + +
Sbjct 2044 IRFTPIGSP-VCDDVVAGYANSS-FDKNEYCN-SVICKVCLYGYQELSDFSHTQVVWQHL 2100
Query 2285 ------QVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISN 2338
V Y L I G +V A L+ F YL L VF G S
Sbjct 2101 RDPLIGNVMPFFYLAFLAIFG--GVYVKAITLYFIFQYLNSLG----VFLGLQQS----- 2149
Query 2339 SWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRV 2398
+WF+ Q+ P + F + H+ GC ++C+ C K R RV
Sbjct 2150 ---IWFL----QLVPFDVFGDEIVVFFIVTRVLMFIKHVCLGCDKASCVACSKSARLKRV 2202
Query 2399 ECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPI 2458
TI G +SFYV+ANGG FCK HN+ CLNCD++ G TFI+D +A ++ K +
Sbjct 2203 PVQTIFQGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGCTFINDVIATEVGNVVKLNV 2262
Query 2459 NPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVI 2518
PT ++ ++D V NG +LY K S + + L+ S+ + I
Sbjct 2263 QPTGPATILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYTCKEALK----NCSIITDFI 2318
Query 2519 VFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSAT 2578
VF+ + + K+A VY+SQ++C+P+ L+D AL++ + S + + A+V S +
Sbjct 2319 VFNNNGS-NVNQVKNACVYFSQMLCKPVKLVDSALLASL--SVDFGASLHSAFVSVLSNS 2375
Query 2579 FSVPMEKLKALVATAHSELAKGVALDGV-LSTFVSAARQGVVDTDVDTKDVIECLKLSHH 2637
F + + + + D V L TF +A + +H
Sbjct 2376 FGKDLSSCNDM-----QDCKSTLGFDDVPLDTFNAAVAE------------------AHR 2412
Query 2638 SDLEVTGDSCNNFMLTYNKVENMTP-RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYM 2696
D+ +T S NNF +Y K E P D+ C+ A+ +N V ++ ++W V+D++
Sbjct 2413 YDVLLTDMSFNNFTTSYAKPEEKFPVHDIATCMRVGAKIVNHNVLVKDSIPVVWLVRDFI 2472
Query 2697 SLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLL 2756
+LSE+ RK I K I F LT R + T I+ K G + + K+ L
Sbjct 2473 ALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIANKKGAGLPSFSKVKKFFWFL 2532
Query 2757 CVLAALVCYIVMPVHTLSIHDGYT----NEIIGYKAIQDGVTRDIISTDDCFANKHAGFD 2812
C+ +IV LS D T + +K I+ G + + C N FD
Sbjct 2533 CL------FIVAAFFALSFLDFSTQVSSDSDYDFKYIESGQLKTFDNPLSCVHNVFINFD 2586
Query 2813 AWFSQRGG-SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGN 2871
W + G + N+ SCP+V + + VPG+P V A G L F
Sbjct 2587 QWHDAKFGFTPVNNPSCPIVVGV--SDEARTVPGIPAGVYLA--GKTLVFAINTIFGTSG 2642
Query 2872 ICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRY 2931
+C+ S + + AC+ + CT +G YCY L+EG+ YSEL P + Y
Sbjct 2643 LCFDASGVAD-----KGACIFNSACTTLS-GLGGTAVYCYKNGLVEGAKLYSELAPHSYY 2696
Query 2932 VLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRA 2990
++DG+ + P G +R + T YCR G C +S G+C +V N E +
Sbjct 2697 KMVDGNAVSLPEIISRGFGIRTIRTKAMTYCRVGQCVQSAEGVCFGADRFFVYNAE---S 2753
Query 2991 LSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGE 3050
S CG L+ N+ + + V +S ++ IIA + + F KF+R+FG+
Sbjct 2754 GSDFVCGTGLFTLLMNVISVFSKTVPVTVLSGQILFNCIIAFVAVAVCFLFTKFKRMFGD 2813
Query 3051 YN-HVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYF--TNDVSFLA--HLQW 3105
+ V A L + + + L Y T YF T V ++ HL +
Sbjct 2814 MSVGVFTVGACTLLNNVSYIVTQNTLGMLG--------YATLYFLCTKGVRYMWIWHLGF 2865
Query 3106 FAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV---MFNGVTF-STFEEAALCTFL 3161
+ I P+W+ +Y F + F N + +V +F G F +FE AA TF+
Sbjct 2866 LISYILIAPWWVLMVYAFSAIFE----FMPNLFKLKVSTQLFEGDKFVGSFENAAAGTFV 2921
Query 3162 LNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS 3221
L+ Y +L + + + +Y + YNKYKY+SG+ YR A HLAKA+ D++++
Sbjct 2922 LDMHAYERLANS--ISTEKLRQYASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYASN 2979
Query 3222 GADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRH 3281
D LY PP S S LQ+G RKMA PSG VE C+V+V G LNGLWL D V CPRH
Sbjct 2980 HNDTLYTPPTVSYNST-LQAGLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRH 3038
Query 3282 VICTAE-DMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPK 3340
VI ++ ++ +Y ++R H+F + +GNV L V+ +M+ LL++KV+ +N TPK
Sbjct 3039 VIASSTTSTIDYDYALSVLRL--HNFSISSGNVFLGVVSATMRGALLQIKVNQNNVHTPK 3096
Query 3341 YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC 3400
Y + ++PG++F++LACY+G+ +GVY MR N+TI+GSF+NG+CGS G+NI+ V FC
Sbjct 3097 YTYRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNINNGTVEFC 3156
Query 3401 YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFL 3460
Y+H +EL +G H G+DL+G YG + D+ T Q G + T NVLA+LYAA+ING W+L
Sbjct 3157 YLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTENVLAFLYAALINGSTWWL 3216
Query 3461 NRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT 3520
+ ++ FN A+ T + D L+A+TG+ V + A+++ L +N G+
Sbjct 3217 SSSRIAVDRFNEWAVHNGMT--TVGNTDCFSILAAKTGVDVQRLLASIQSLHKN-FGGKQ 3273
Query 3521 ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWML----LTFLTSLLILVQSTQ 3576
ILG T L DEFT +VVRQ GV QG + + + + +L LTF S L+
Sbjct 3274 ILGHTSLTDEFTTGEVVRQMYGVNLQGGY--VSRACRNVLLVGSFLTFFWSELV-----S 3326
Query 3577 WSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASW 3636
++ FF+V P + +++ M +KHK F +FL+P+L + N+ +
Sbjct 3327 YTKFFWVNPGYVTPMFACLSLLSSLLMFTLKHKTLFFQVFLIPALIVTSCINLAF----- 3381
Query 3637 VMRIMTWLELAD-----TSLSGYRLKDCVMYASALVLLILMTART--VYDDAARRVWTLM 3689
+ + LA+ SL G+ + V V+ IL T ++ A V ++
Sbjct 3382 --DVEVYNYLAEHFDYHVSLMGFNAQGLVNIFVCFVVTILHGTYTWRFFNTPASSVTYVV 3439
Query 3690 NVITLVYKVYYG-NALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFI 3748
++T Y +Y + L A++++A SVT N+ V + + + V++ + + + I
Sbjct 3440 ALLTAAYNYFYASDILSCAMTLFA---SVTGNW--FVGAVCY--KVAVYMALRFPTFVAI 3492
Query 3749 TGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPP 3808
G+ ++ +M Y LGY CC++G+ NR+F++++GVYDY VS EF+YM + GL P
Sbjct 3493 FGD-IKSVMFCYLVLGYFTCCFYGILYWFNRFFKVSVGVYDYTVSAAEFKYMVANGLRAP 3551
Query 3809 KSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQC 3868
++D+ L+ KL+GIGG+ IK+++VQSK++D+KC++VVLL L + V ++S WA C
Sbjct 3552 TGTLDSLLLSAKLIGIGGERNIKISSVQSKLTDIKCSNVVLLGCLSSMNVSANSTEWAYC 3611
Query 3869 VQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSL 3928
V LHN I L D +A E +++LL+ LS A ++ L E ++ + LQ++AS + L
Sbjct 3612 VDLHNKINLCNDPEKAQEMLLALLAFFLSKNSAFGLDDLLESYFNDNSMLQSVASTYVGL 3671
Query 3929 PSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQ 3988
PSY Y A++ YE AV NG ++K+L+ ++NVAKSEFDR+A+ QRKL++MA+QA Q
Sbjct 3672 PSYVIYENARQQYEDAVNNGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAAAQ 3731
Query 3989 MYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLM 4048
MYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N A+DG VPL++IP +A KL
Sbjct 3732 MYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVPLSVIPAVSATKLN 3791
Query 4049 VVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTAL 4108
+V D +Y YA +W I + D D K+V + E+ N+ +L+WPL++
Sbjct 3792 IVTSDIDSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQNAESLSWPLVLGCE 3851
Query 4109 RANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDL 4168
R VKLQNNE+ P L+Q S A A YNN G F+ A +SD DL
Sbjct 3852 R---IVKLQNNEIIPGKLKQRSIKAEGDGIV---GEGKALYNNEGGRTFMYAFISDKPDL 3905
Query 4169 KWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVR 4228
+ ++ G TI ELEPP +F+ D+P G ++KYLYF++ LN L RG VLG + ATVR
Sbjct 3906 RVVKWEFDGGCNTI--ELEPPRKFLVDSPNGAQIKYLYFVRNLNTLRRGAVLGYIGATVR 3963
Query 4229 LQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVT 4288
LQAG TE NS++L+ CAFAVDPAK Y D + SG +P+ NCVKML +G GQA+T
Sbjct 3964 LQAGKQTEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTNG 4023
Query 4289 PEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCT 4348
EA+ +Q+S+GGAS CLYCR H++HP+ GFC LKGKYVQ+P DP+ F L N VC
Sbjct 4024 VEASTNQDSYGGASVCLYCRAHVEHPSMDGFCRLKGKYVQVPLGTV-DPIRFVLENDVCK 4082
Query 4349 VCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
VCG W GC+CD+ +MQS D + +LN
Sbjct 4083 VCGCWLSNGCTCDR---SIMQSTDMA-YLN 4108
Score = 87.4 bits (215), Expect = 4e-15, Method: Compositional matrix adjust.
Identities = 86/282 (30%), Positives = 133/282 (47%), Gaps = 29/282 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNAAN L HGGG+A A++ T G +QK S+DYIK +GP+ VG +L L K +
Sbjct 1317 VVNAANEKLSHGGGIAKAIDVYTKGMLQKCSNDYIKAHGPIKVGRGVMLEA--LGLKVFN 1374
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGA---KPLQSLQVCVQTVRTQV 1151
VVGP L+KA F + + L PL+S GIF + L + CV +
Sbjct 1375 VVGPRKGKHAPELLVKAYKSVFANSGVALTPLISVGIFSVPLEESLSAFLACVGDRHCKC 1434
Query 1152 YIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPV--DVKP-KI 1208
+ DK + ++ Y+D L V+A +E +T + + + V QKPV + +P +I
Sbjct 1435 F-CYGDKE--REAIIKYMDGL---VDAIFKEALVDTTPVQEDVQQVSQKPVLPNFEPFRI 1488
Query 1209 KA------CIDEVTTTLEETKFL--TNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
+ C E +L K + TN L F + GK +D + E ++ +K
Sbjct 1489 EGAHAFYECNPEGLMSLGADKLVLFTNSNLDFCSV-GKCLNDVTSGALLEAINVFKKSNK 1547
Query 1261 YM-VGDVITSG-----DITCVVIPSKKAGGTTEMLSRALKKV 1296
+ G+ +T IT VV+P + +RA+ KV
Sbjct 1548 TVPAGNCVTLDCANMISITMVVLPFDGDANYDKNYARAVVKV 1589
Score = 50.8 bits (120), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 82/327 (25%), Positives = 131/327 (40%), Gaps = 37/327 (11%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K++ + T D ++ V+ + TYGQQ GP ++ VT KP V V+P+ +
Sbjct 1631 KSVVIKVTEDTRSVKAVKVESTATYGQQIGPCLVNDTVVTDNKPVVADVVAK--VVPNAN 1688
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQ--VGGLTSIKWADNNCYLSSVLLAL 1660
++ ++ D++ G + L+HT + FP V G IK DNNC+++ L L
Sbjct 1689 ------WDSHYGFDKA--GEF-HMLDHTG-FTFPSEVVNGRRVIKTTDNNCWVNVTCLQL 1738
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQH---AN 1717
Q +F + LQ + GD A F + + G+ D + L ++ A
Sbjct 1739 QFARFRFKSAGLQAMWESYCTGDVAMFVHWLYWLTGVDKGQPSDSENALNMLSKYIVPAG 1798
Query 1718 LESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDAT-QYLV 1775
+ +RV + C C ++ T V A + LK GV C G + + +V
Sbjct 1799 SVTIERVTHDGC-CCSKRVVTAPVVNASV---------LKLGVEDGLCPHGLNYIGKVVV 1848
Query 1776 QQESSFVMMSAPPAEYKLQQGTFLCANEYT-----GNYQCGHYTHITAKETLYRIDGAHL 1830
+ ++ V+ P FL YT GN GHYT + DG
Sbjct 1849 VKGTTIVVNVGKPV--VAPSHLFLKGVSYTTFLDNGNGVVGHYTVFDHGTGMVH-DGDAF 1905
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPV 1857
PVT+V E + PV
Sbjct 1906 VPGDLNVSPVTNVVVSEQTAVVIKDPV 1932
Score = 40.0 bits (92), Expect = 0.66, Method: Compositional matrix adjust.
Identities = 31/101 (31%), Positives = 49/101 (49%), Gaps = 8/101 (8%)
Query 1633 WKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALIL 1692
+ F GGL ++ + NNC+++S L+ LQ L + + PA+ E + R G C
Sbjct 1073 FDFVSYGGLKVLRQSHNNCWVTSTLVQLQLLGI-VDDPAM-ELFSAGRVGPMVRKC---Y 1127
Query 1693 AYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCG 1733
+G LGDV + L + +L + K +VVC CG
Sbjct 1128 ESQKAILGSLGDVSACLESLTK--DLHTLKITCSVVCG-CG 1165
>sp|P0C6U2|R1A_CVH22 Replicase polyprotein 1a OS=Human coronavirus
229E OX=11137 GN=1a PE=1 SV=1
Length=4085
Score = 1186 bits (3068), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 768/2268 (34%), Positives = 1180/2268 (52%), Gaps = 202/2268 (9%)
Query 2173 TTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAM-----WLLLLSICLGSLICVTAAF 2227
T + VK +AK G+ +S K++ + A+ WLL L LI +
Sbjct 1949 TAVTTGDVKIMAKAPQRTGVVLKRSLKYNLKASAAVLKSKWWLLAKFTKLLLLIYTLYSV 2008
Query 2228 GVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+L FG ++C+ Y SN D+C+GS C +CL G L + L+ +
Sbjct 2009 VLLCVRFGPFNFCSETVNGYA-KSNFVKDDYCDGSLGCKMCLFGYQELSQFSHLDVVWKH 2067
Query 2288 ISS--------YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
I+ + + + +L ++ ++L+ ++ + + + VF GY ++
Sbjct 2068 ITDPLFSNMQPFIVMVLLLIFGDNYLRCFLLY----FVAQMISTVGVFLGYKETN----- 2118
Query 2340 WLMWFII--SIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATR 2397
W + FI I V+ +V I F H++ GC + C+ C K R R
Sbjct 2119 WFLHFIPFDVICDELLVTVIVIKVISFVR---------HVLFGCENPDCIACSKSARLKR 2169
Query 2398 VECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRP 2457
TIVNG++RSFYV ANGG FCK H + C++CD++ GSTFI+ EV+R+L K
Sbjct 2170 FPVNTIVNGVQRSFYVNANGGSKFCKKHRFFCVDCDSYGYGSTFITPEVSRELGNITKTN 2229
Query 2458 INPTDQSSYIVDSVAVKNGALHLY---------FDKAGQKTYERHPLSHFVNLDNLRANN 2508
+ PT + ++D V +NG LY FD K + + LD+ N
Sbjct 2230 VQPTGPAYVMIDKVEFENGFYRLYSCETFWRYNFDITESKYSCKEVFKNCNVLDDFIVFN 2289
Query 2509 TKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMF 2568
G+ + + K+ASVY+SQL+C+PI L+D L+S + S + + +
Sbjct 2290 NNGT--------------NVTQVKNASVYFSQLLCRPIKLVDSELLSTL--SVDFNGVLH 2333
Query 2569 DAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDV 2628
AY+D +F + L A ++ A + A G+++ F SA
Sbjct 2334 KAYIDVLRNSFG---KDLNANMSLAECKRALGLSISD--HEFTSAISN------------ 2376
Query 2629 IECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTPRDLGACIDCNARHINAQVAKSHNVS 2687
+H D+ ++ S NNF+ +Y K E ++ DL C+ A+ +NA V
Sbjct 2377 ------AHRCDVLLSDLSFNNFVSSYAKPEEKLSAYDLACCMRAGAKVVNANVLTKDQTP 2430
Query 2688 LIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLK--GGKIVST 2745
++W+ KD+ SLS + RK I +K + F LT + V + T I K G +
Sbjct 2431 IVWHAKDFNSLSAEGRKYIVKTSKAKGLTFLLTINENQAVTQIPATSIVAKQGAGDAGHS 2490
Query 2746 CFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFA 2805
L L L+C++ +C+ MP I + E +K I++G ++ + C
Sbjct 2491 LTWLWLLCGLVCLIQFYLCFF-MPYFMYDIVSSF--EGYDFKYIENGQLKNFEAPLKCVR 2547
Query 2806 NKHAGFDAW-FSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPR 2864
N F+ W +++ G + N +SCP+V + EI V G+P V + G L F +
Sbjct 2548 NVFENFEDWHYAKFGFTPLNKQSCPIVVGV--SEIVNTVAGIPSNVY--LVGKTLIFTLQ 2603
Query 2865 VFSAVGNICY------TPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEG 2918
+CY TP K C+ + CT + G V YCY+T L+EG
Sbjct 2604 AAFGNAGVCYDIFGVTTPEK-----------CIFTSACTRLEGLGGNNV-YCYNTALMEG 2651
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLST 2977
S+ YS ++ + Y +G+ I+ P +G R V T +YCR G C S G+C
Sbjct 2652 SLPYSSIQANAYYKYDNGNFIKLPEVIAQGFGFRTVRTIATKYCRVGECVESNAGVCFGF 2711
Query 2978 SGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCA 3037
+W +N+ R +G CG NL+ NI + +S ++ +
Sbjct 2712 D-KWFVNDG--RVANGYVCGTGLWNLVFNILSMFSSSFSVAAMSGQILLNCALGAFAIFC 2768
Query 3038 AYYFMKFRRVFGEYN----------------HVVAANALLFLMSFTILCLVPAYSFLPGV 3081
+ KFRR+FG+ + ++V N L+ ++++ IL Y F
Sbjct 2769 CFLVTKFRRMFGDLSVGVCTVVVAVLLNNVSYIVTQN-LVTMIAYAIL-----YFFATRS 2822
Query 3082 YSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKR 3141
+++ Y +SF P+W+ A Y L + L+ +
Sbjct 2823 LRYAWIWCAAYLIAYISF-------------APWWLCAWYF----LAMLTGLLPSLLKLK 2865
Query 3142 V---MFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
V +F G F TFE AA TF+++ Y KL + ++ P + Y A YN+YKY+SG
Sbjct 2866 VSTNLFEGDKFVGTFESAAAGTFVIDMRSYEKL-ANSISP-EKLKSYAASYNRYKYYSGN 2923
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
+ YR A +LAKA+ DFS D+LY PP S S LQ+G RKMA PSG VE C+
Sbjct 2924 ANEADYRCACYAYLAKAMLDFSRDHNDILYTPPTVSYGST-LQAGLRKMAQPSGFVEKCV 2982
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICT-AEDMLNPNYEDLLIRKSNHSFLVQAGNVQLR 3316
V+V G T LNGLWL D VYCPRHVI + ++ ++E ++R H+F + +G L
Sbjct 2983 VRVCYGNTVLNGLWLGDIVYCPRHVIASNTTSAIDYDHEYSIMRL--HNFSIISGTAFLG 3040
Query 3317 VIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTI 3376
V+G +M L++KV +N TP++ F ++ G+ F++LACY+G GV+ MR N TI
Sbjct 3041 VVGATMHGVTLKIKVSQTNMHTPRHSFRTLKSGEGFNILACYDGCAQGVFGVNMRTNWTI 3100
Query 3377 KGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
+GSF+NG+CGS G+N+ V F YMH +EL +G H G+ +G YG F D+ Q
Sbjct 3101 RGSFINGACGSPGYNLKNGEVEFVYMHQIELGSGSHVGSSFDGVMYGGFEDQPNLQVESA 3160
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
+ +T+NV+A+LYAA++NG W+L + +N A + + + D L+A+
Sbjct 3161 NQMLTVNVVAFLYAAILNGCTWWLKGEKLFVEHYNEWAQANGFTAMNGE--DAFSILAAK 3218
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKG 3555
TG+ V + A+ ++L NG G+ ILG + L DEF+ +VV+Q GV Q GK + K
Sbjct 3219 TGVCVERLLHAI-QVLNNGFGGKQILGYSSLNDEFSINEVVKQMFGVNLQSGKTTSMFKS 3277
Query 3556 THHWM-LLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLC 3614
+ + L + +T W V PF + ++A++ C +VKHK FL
Sbjct 3278 ISLFAGFFVMFWAELFVYTTTIW-----VNPGFLTPFMILLVALSLCLTFVVKHKVLFLQ 3332
Query 3615 LFLLPSLATVAYFNMVYMPASW---VMRIMTWLELADTSLSGYRLKDCVMYASALVLLIL 3671
+FLLPS+ A N +W V +++ + S+ ++ V L + +L
Sbjct 3333 VFLLPSIIVAAIQN-----CAWDYHVTKVLAEKFDYNVSVMQMDIQGFVNIFICLFVALL 3387
Query 3672 MTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFL 3731
T R + L ++I ++Y Y +S+ +++ SN + I +
Sbjct 3388 HTWRFAKERCTHWCTYLFSLIAVLYTALYSY---DYVSLLVMLLCAISNEWYIGAIIFRI 3444
Query 3732 AR-AIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
R + F+ VEY + ++ ++L Y LG+ C Y+GL +NR+ + TLGVYD+
Sbjct 3445 CRFGVAFLPVEYVSYF----DGVKTVLLFYMLLGFVSCMYYGLLYWINRFCKCTLGVYDF 3500
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
VS EF+YM + GL P DA L+ KL+GIGG IKV+TVQSK++D+KCT+VVL+
Sbjct 3501 CVSPAEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQSKLTDLKCTNVVLM 3560
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
+L + + S+SK WA CV++HN I L D A E +++LL+ LS + L +
Sbjct 3561 GILSNMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFGLGDLVDS 3620
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDR 3970
+N + LQ++AS F +PS+ AY TA++ YE AVANG S ++K+LKK++NVAK+EFDR
Sbjct 3621 YFENDSILQSVASSFVGMPSFVAYETARQEYENAVANGSSPQIIKQLKKAMNVAKAEFDR 3680
Query 3971 DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNAR 4030
++++Q+K+ +MA+QA MYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N AR
Sbjct 3681 ESSVQKKINRMAEQAAAAMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNMAR 3740
Query 4031 DGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSE 4090
+G VPL++IP T+AA+L+VVVPD+ ++ YA +W +Q+V D D K V L +
Sbjct 3741 NGVVPLSVIPATSAARLVVVVPDHDSFVKMMVDGFVHYAGVVWTLQEVKDNDGKNVHLKD 3800
Query 4091 INMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN 4150
+ +N L WPLI+T R VKLQNNE+ P ++ + ++ NAL YN
Sbjct 3801 VTKENQEILVWPLILTCER---VVKLQNNEIMPGKMKVKATKGEGDGGITSEGNAL--YN 3855
Query 4151 NSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKG 4210
N G F+ A ++ +K+ ++ G T+ ELEPPCRFV DTP GP++KYLYF+K
Sbjct 3856 NEGGRAFMYAYVTTKPGMKYVKWEHDSGVVTV--ELEPPCRFVIDTPTGPQIKYLYFVKN 3913
Query 4211 LNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITN 4270
LNNL RG VLG + ATVRLQAG TE +NS +L+ C+FAVDPA AY D + G +P+ N
Sbjct 3914 LNNLRRGAVLGYIGATVRLQAGKQTEFVSNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGN 3973
Query 4271 CVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIP 4330
CVKML +G+GQAIT T ++N Q+++GGAS C+YCR H+ HP GFC KGK+VQ+P
Sbjct 3974 CVKMLTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHPTMDGFCQYKGKWVQVP 4033
Query 4331 TTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
NDP+ F L NTVC VCG W +GC+CD+ +QS D S +LN
Sbjct 4034 IG-TNDPIRFCLENTVCKVCGCWLNHGCTCDR---TAIQSFDNS-YLN 4076
Score = 86.7 bits (213), Expect = 6e-15, Method: Compositional matrix adjust.
Identities = 66/196 (34%), Positives = 99/196 (51%), Gaps = 10/196 (5%)
Query 993 PEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGA 1052
P+ E +E +N F + DNVA D+ + IVNAAN +L HGGG+A A
Sbjct 1262 PKEEFVVKEKLNAFL----VHDNVAFYQGDVDTVVNGVDFDFIVNAANENLAHGGGLAKA 1317
Query 1053 LNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAA 1112
L+ T G +Q+ S ++I L G + VG ++ +L + +VVGP E L+KA
Sbjct 1318 LDVYTKGKLQRLSKEHIGLAGKVKVGTGVMVECDSL--RIFNVVGPRKGKHERDLLIKAY 1375
Query 1113 YENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT---QVYIAVNDKALYEQVVMDYL 1169
N Q L P+LS GIFG K SL+V + T +V++ + + + + L
Sbjct 1376 NTINNEQGTPLTPILSCGIFGIKLETSLEVLLDVCNTKEVKVFVYTDTEVCKVKDFVSGL 1435
Query 1170 DNLKPRVEAPKQEEPP 1185
N++ +VE PK E P
Sbjct 1436 VNVQ-KVEQPKIEPKP 1450
Score = 68.6 bits (166), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 84/340 (25%), Positives = 139/340 (41%), Gaps = 32/340 (9%)
Query 1537 LSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFF 1596
L E K I + T D N+H V ++ QQ G D++ P + +
Sbjct 1595 LKAAEAKVITIKVTEDGVNVHDVTVTTDKSFEQQVGVIADKDKDLSGAVPSDLNTSELLT 1654
Query 1597 VLPSDDTLRSEAFE---YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYL 1653
D + F+ + T+D S Y SA+ V G+ +K +DNNC++
Sbjct 1655 KAIDVDWVEFYGFKDAVTFATVDHSAFA-YESAV----------VNGIRVLKTSDNNCWV 1703
Query 1654 SSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLL 1713
++V +ALQ + F + L A+ + GD F A + + G+ GD +T+T L
Sbjct 1704 NAVCIALQYSKPHFISQGLDAAWNKFVLGDVEIFVAFVYYVARLMKGDKGDAEDTLTKLS 1763
Query 1714 QH-ANLESAKRVLNVVCKHCGQK-TTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ AN + C C K ++ + + + ++ D ++ G CV G
Sbjct 1764 KYLANEAQVQLEHYSSCVECDAKFKNSVASINSAIVCASVKRDGVQVGY---CVHGIKYY 1820
Query 1772 QYLVQQESSFVMMSA----PPAEYKLQQGTFLCANEYTGNYQCGHYT-HITAKETLYRID 1826
+ +++S P A+ +L G A ++G GHYT + TAK+++Y D
Sbjct 1821 SRVRSVRGRAIIVSVEQLEPCAQSRLLSGVAYTA--FSGPVDKGHYTVYDTAKKSMY--D 1876
Query 1827 GAHLTKMSEYKGPVTDVF----YKETSYTTTIKPVSYKLD 1862
G K VT V Y T KPV +LD
Sbjct 1877 GDRFVKHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLD 1916
Score = 49.3 bits (116), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 61/266 (23%), Positives = 109/266 (41%), Gaps = 20/266 (8%)
Query 1635 FPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAY 1694
F ++ GL +K DNNC+++SV+L +Q + A+Q + G A
Sbjct 1038 FEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQ----FFKMGRVAKMIERCYTA 1093
Query 1695 SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
G +GDV M LL+ +L + V++ C C +G AV++ T +
Sbjct 1094 EQCIRGAMGDVGLCMYRLLK--DLHTGFMVMDYKCS-CTSGRLEESG--AVLFC-TPTKK 1147
Query 1755 NLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHY- 1813
G + C R T +Q FV P +C++ + G CGHY
Sbjct 1148 AFPYGTCLNCNAPRMCTIRQLQGTIIFVQQKPEPVNPVSFVVKPVCSSIFRGAVSCGHYQ 1207
Query 1814 THITAKETLYRIDGAHLTKMSEYKG-PVTDVFYKETSYTT----TIKPVSYKLDGVTYTE 1868
T+I ++ +DG + K+ + + + K+ Y ++ P+ +D E
Sbjct 1208 TNIYSQNLC--VDGFGVNKIQPWTNDALNTICIKDADYNAKVEISVTPIKNTVDTTPKEE 1265
Query 1869 --IEPKLDGYYKKDNAYYTEQPIDLV 1892
++ KL+ + DN + + +D V
Sbjct 1266 FVVKEKLNAFLVHDNVAFYQGDVDTV 1291
>sp|P0C6X1|R1AB_CVH22 Replicase polyprotein 1ab OS=Human coronavirus
229E OX=11137 GN=rep PE=1 SV=1
Length=6758
Score = 1186 bits (3067), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 768/2268 (34%), Positives = 1180/2268 (52%), Gaps = 202/2268 (9%)
Query 2173 TTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAM-----WLLLLSICLGSLICVTAAF 2227
T + VK +AK G+ +S K++ + A+ WLL L LI +
Sbjct 1949 TAVTTGDVKIMAKAPQRTGVVLKRSLKYNLKASAAVLKSKWWLLAKFTKLLLLIYTLYSV 2008
Query 2228 GVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+L FG ++C+ Y SN D+C+GS C +CL G L + L+ +
Sbjct 2009 VLLCVRFGPFNFCSETVNGYA-KSNFVKDDYCDGSLGCKMCLFGYQELSQFSHLDVVWKH 2067
Query 2288 ISS--------YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
I+ + + + +L ++ ++L+ ++ + + + VF GY ++
Sbjct 2068 ITDPLFSNMQPFIVMVLLLIFGDNYLRCFLLY----FVAQMISTVGVFLGYKETN----- 2118
Query 2340 WLMWFII--SIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATR 2397
W + FI I V+ +V I F H++ GC + C+ C K R R
Sbjct 2119 WFLHFIPFDVICDELLVTVIVIKVISFVR---------HVLFGCENPDCIACSKSARLKR 2169
Query 2398 VECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRP 2457
TIVNG++RSFYV ANGG FCK H + C++CD++ GSTFI+ EV+R+L K
Sbjct 2170 FPVNTIVNGVQRSFYVNANGGSKFCKKHRFFCVDCDSYGYGSTFITPEVSRELGNITKTN 2229
Query 2458 INPTDQSSYIVDSVAVKNGALHLY---------FDKAGQKTYERHPLSHFVNLDNLRANN 2508
+ PT + ++D V +NG LY FD K + + LD+ N
Sbjct 2230 VQPTGPAYVMIDKVEFENGFYRLYSCETFWRYNFDITESKYSCKEVFKNCNVLDDFIVFN 2289
Query 2509 TKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMF 2568
G+ + + K+ASVY+SQL+C+PI L+D L+S + S + + +
Sbjct 2290 NNGT--------------NVTQVKNASVYFSQLLCRPIKLVDSELLSTL--SVDFNGVLH 2333
Query 2569 DAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDV 2628
AY+D +F + L A ++ A + A G+++ F SA
Sbjct 2334 KAYIDVLRNSFG---KDLNANMSLAECKRALGLSISD--HEFTSAISN------------ 2376
Query 2629 IECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTPRDLGACIDCNARHINAQVAKSHNVS 2687
+H D+ ++ S NNF+ +Y K E ++ DL C+ A+ +NA V
Sbjct 2377 ------AHRCDVLLSDLSFNNFVSSYAKPEEKLSAYDLACCMRAGAKVVNANVLTKDQTP 2430
Query 2688 LIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLK--GGKIVST 2745
++W+ KD+ SLS + RK I +K + F LT + V + T I K G +
Sbjct 2431 IVWHAKDFNSLSAEGRKYIVKTSKAKGLTFLLTINENQAVTQIPATSIVAKQGAGDAGHS 2490
Query 2746 CFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFA 2805
L L L+C++ +C+ MP I + E +K I++G ++ + C
Sbjct 2491 LTWLWLLCGLVCLIQFYLCFF-MPYFMYDIVSSF--EGYDFKYIENGQLKNFEAPLKCVR 2547
Query 2806 NKHAGFDAW-FSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPR 2864
N F+ W +++ G + N +SCP+V + EI V G+P V + G L F +
Sbjct 2548 NVFENFEDWHYAKFGFTPLNKQSCPIVVGV--SEIVNTVAGIPSNVY--LVGKTLIFTLQ 2603
Query 2865 VFSAVGNICY------TPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEG 2918
+CY TP K C+ + CT + G V YCY+T L+EG
Sbjct 2604 AAFGNAGVCYDIFGVTTPEK-----------CIFTSACTRLEGLGGNNV-YCYNTALMEG 2651
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLST 2977
S+ YS ++ + Y +G+ I+ P +G R V T +YCR G C S G+C
Sbjct 2652 SLPYSSIQANAYYKYDNGNFIKLPEVIAQGFGFRTVRTIATKYCRVGECVESNAGVCFGF 2711
Query 2978 SGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCA 3037
+W +N+ R +G CG NL+ NI + +S ++ +
Sbjct 2712 D-KWFVNDG--RVANGYVCGTGLWNLVFNILSMFSSSFSVAAMSGQILLNCALGAFAIFC 2768
Query 3038 AYYFMKFRRVFGE----------------YNHVVAANALLFLMSFTILCLVPAYSFLPGV 3081
+ KFRR+FG+ +++V N L+ ++++ IL Y F
Sbjct 2769 CFLVTKFRRMFGDLSVGVCTVVVAVLLNNVSYIVTQN-LVTMIAYAIL-----YFFATRS 2822
Query 3082 YSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKR 3141
+++ Y +SF P+W+ A Y L + L+ +
Sbjct 2823 LRYAWIWCAAYLIAYISF-------------APWWLCAWYF----LAMLTGLLPSLLKLK 2865
Query 3142 V---MFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
V +F G F TFE AA TF+++ Y KL + ++ P + Y A YN+YKY+SG
Sbjct 2866 VSTNLFEGDKFVGTFESAAAGTFVIDMRSYEKL-ANSISP-EKLKSYAASYNRYKYYSGN 2923
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
+ YR A +LAKA+ DFS D+LY PP S S LQ+G RKMA PSG VE C+
Sbjct 2924 ANEADYRCACYAYLAKAMLDFSRDHNDILYTPPTVSYGST-LQAGLRKMAQPSGFVEKCV 2982
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICT-AEDMLNPNYEDLLIRKSNHSFLVQAGNVQLR 3316
V+V G T LNGLWL D VYCPRHVI + ++ ++E ++R H+F + +G L
Sbjct 2983 VRVCYGNTVLNGLWLGDIVYCPRHVIASNTTSAIDYDHEYSIMRL--HNFSIISGTAFLG 3040
Query 3317 VIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTI 3376
V+G +M L++KV +N TP++ F ++ G+ F++LACY+G GV+ MR N TI
Sbjct 3041 VVGATMHGVTLKIKVSQTNMHTPRHSFRTLKSGEGFNILACYDGCAQGVFGVNMRTNWTI 3100
Query 3377 KGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
+GSF+NG+CGS G+N+ V F YMH +EL +G H G+ +G YG F D+ Q
Sbjct 3101 RGSFINGACGSPGYNLKNGEVEFVYMHQIELGSGSHVGSSFDGVMYGGFEDQPNLQVESA 3160
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
+ +T+NV+A+LYAA++NG W+L + +N A + + + D L+A+
Sbjct 3161 NQMLTVNVVAFLYAAILNGCTWWLKGEKLFVEHYNEWAQANGFTAMNGE--DAFSILAAK 3218
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKG 3555
TG+ V + A+ ++L NG G+ ILG + L DEF+ +VV+Q GV Q GK + K
Sbjct 3219 TGVCVERLLHAI-QVLNNGFGGKQILGYSSLNDEFSINEVVKQMFGVNLQSGKTTSMFKS 3277
Query 3556 THHWM-LLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLC 3614
+ + L + +T W V PF + ++A++ C +VKHK FL
Sbjct 3278 ISLFAGFFVMFWAELFVYTTTIW-----VNPGFLTPFMILLVALSLCLTFVVKHKVLFLQ 3332
Query 3615 LFLLPSLATVAYFNMVYMPASW---VMRIMTWLELADTSLSGYRLKDCVMYASALVLLIL 3671
+FLLPS+ A N +W V +++ + S+ ++ V L + +L
Sbjct 3333 VFLLPSIIVAAIQN-----CAWDYHVTKVLAEKFDYNVSVMQMDIQGFVNIFICLFVALL 3387
Query 3672 MTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFL 3731
T R + L ++I ++Y Y +S+ +++ SN + I +
Sbjct 3388 HTWRFAKERCTHWCTYLFSLIAVLYTALYSY---DYVSLLVMLLCAISNEWYIGAIIFRI 3444
Query 3732 AR-AIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
R + F+ VEY + ++ ++L Y LG+ C Y+GL +NR+ + TLGVYD+
Sbjct 3445 CRFGVAFLPVEYVSYF----DGVKTVLLFYMLLGFVSCMYYGLLYWINRFCKCTLGVYDF 3500
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
VS EF+YM + GL P DA L+ KL+GIGG IKV+TVQSK++D+KCT+VVL+
Sbjct 3501 CVSPAEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQSKLTDLKCTNVVLM 3560
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
+L + + S+SK WA CV++HN I L D A E +++LL+ LS + L +
Sbjct 3561 GILSNMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFGLGDLVDS 3620
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDR 3970
+N + LQ++AS F +PS+ AY TA++ YE AVANG S ++K+LKK++NVAK+EFDR
Sbjct 3621 YFENDSILQSVASSFVGMPSFVAYETARQEYENAVANGSSPQIIKQLKKAMNVAKAEFDR 3680
Query 3971 DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNAR 4030
++++Q+K+ +MA+QA MYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N AR
Sbjct 3681 ESSVQKKINRMAEQAAAAMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNMAR 3740
Query 4031 DGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSE 4090
+G VPL++IP T+AA+L+VVVPD+ ++ YA +W +Q+V D D K V L +
Sbjct 3741 NGVVPLSVIPATSAARLVVVVPDHDSFVKMMVDGFVHYAGVVWTLQEVKDNDGKNVHLKD 3800
Query 4091 INMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN 4150
+ +N L WPLI+T R VKLQNNE+ P ++ + ++ NAL YN
Sbjct 3801 VTKENQEILVWPLILTCER---VVKLQNNEIMPGKMKVKATKGEGDGGITSEGNAL--YN 3855
Query 4151 NSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKG 4210
N G F+ A ++ +K+ ++ G T+ ELEPPCRFV DTP GP++KYLYF+K
Sbjct 3856 NEGGRAFMYAYVTTKPGMKYVKWEHDSGVVTV--ELEPPCRFVIDTPTGPQIKYLYFVKN 3913
Query 4211 LNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITN 4270
LNNL RG VLG + ATVRLQAG TE +NS +L+ C+FAVDPA AY D + G +P+ N
Sbjct 3914 LNNLRRGAVLGYIGATVRLQAGKQTEFVSNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGN 3973
Query 4271 CVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIP 4330
CVKML +G+GQAIT T ++N Q+++GGAS C+YCR H+ HP GFC KGK+VQ+P
Sbjct 3974 CVKMLTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHPTMDGFCQYKGKWVQVP 4033
Query 4331 TTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
NDP+ F L NTVC VCG W +GC+CD+ +QS D S +LN
Sbjct 4034 IG-TNDPIRFCLENTVCKVCGCWLNHGCTCDR---TAIQSFDNS-YLN 4076
Score = 87.0 bits (214), Expect = 5e-15, Method: Compositional matrix adjust.
Identities = 66/196 (34%), Positives = 99/196 (51%), Gaps = 10/196 (5%)
Query 993 PEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGA 1052
P+ E +E +N F + DNVA D+ + IVNAAN +L HGGG+A A
Sbjct 1262 PKEEFVVKEKLNAFL----VHDNVAFYQGDVDTVVNGVDFDFIVNAANENLAHGGGLAKA 1317
Query 1053 LNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAA 1112
L+ T G +Q+ S ++I L G + VG ++ +L + +VVGP E L+KA
Sbjct 1318 LDVYTKGKLQRLSKEHIGLAGKVKVGTGVMVECDSL--RIFNVVGPRKGKHERDLLIKAY 1375
Query 1113 YENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT---QVYIAVNDKALYEQVVMDYL 1169
N Q L P+LS GIFG K SL+V + T +V++ + + + + L
Sbjct 1376 NTINNEQGTPLTPILSCGIFGIKLETSLEVLLDVCNTKEVKVFVYTDTEVCKVKDFVSGL 1435
Query 1170 DNLKPRVEAPKQEEPP 1185
N++ +VE PK E P
Sbjct 1436 VNVQ-KVEQPKIEPKP 1450
Score = 68.2 bits (165), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 84/340 (25%), Positives = 139/340 (41%), Gaps = 32/340 (9%)
Query 1537 LSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFF 1596
L E K I + T D N+H V ++ QQ G D++ P + +
Sbjct 1595 LKAAEAKVITIKVTEDGVNVHDVTVTTDKSFEQQVGVIADKDKDLSGAVPSDLNTSELLT 1654
Query 1597 VLPSDDTLRSEAFE---YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYL 1653
D + F+ + T+D S Y SA+ V G+ +K +DNNC++
Sbjct 1655 KAIDVDWVEFYGFKDAVTFATVDHSAFA-YESAV----------VNGIRVLKTSDNNCWV 1703
Query 1654 SSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLL 1713
++V +ALQ + F + L A+ + GD F A + + G+ GD +T+T L
Sbjct 1704 NAVCIALQYSKPHFISQGLDAAWNKFVLGDVEIFVAFVYYVARLMKGDKGDAEDTLTKLS 1763
Query 1714 QH-ANLESAKRVLNVVCKHCGQK-TTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ AN + C C K ++ + + + ++ D ++ G CV G
Sbjct 1764 KYLANEAQVQLEHYSSCVECDAKFKNSVASINSAIVCASVKRDGVQVGY---CVHGIKYY 1820
Query 1772 QYLVQQESSFVMMSA----PPAEYKLQQGTFLCANEYTGNYQCGHYT-HITAKETLYRID 1826
+ +++S P A+ +L G A ++G GHYT + TAK+++Y D
Sbjct 1821 SRVRSVRGRAIIVSVEQLEPCAQSRLLSGVAYTA--FSGPVDKGHYTVYDTAKKSMY--D 1876
Query 1827 GAHLTKMSEYKGPVTDVF----YKETSYTTTIKPVSYKLD 1862
G K VT V Y T KPV +LD
Sbjct 1877 GDRFVKHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLD 1916
Score = 49.3 bits (116), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 61/266 (23%), Positives = 109/266 (41%), Gaps = 20/266 (8%)
Query 1635 FPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAY 1694
F ++ GL +K DNNC+++SV+L +Q + A+Q + G A
Sbjct 1038 FEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQ----FFKMGRVAKMIERCYTA 1093
Query 1695 SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYD 1754
G +GDV M LL+ +L + V++ C C +G AV++ T +
Sbjct 1094 EQCIRGAMGDVGLCMYRLLK--DLHTGFMVMDYKCS-CTSGRLEESG--AVLFC-TPTKK 1147
Query 1755 NLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHY- 1813
G + C R T +Q FV P +C++ + G CGHY
Sbjct 1148 AFPYGTCLNCNAPRMCTIRQLQGTIIFVQQKPEPVNPVSFVVKPVCSSIFRGAVSCGHYQ 1207
Query 1814 THITAKETLYRIDGAHLTKMSEYKG-PVTDVFYKETSYTT----TIKPVSYKLDGVTYTE 1868
T+I ++ +DG + K+ + + + K+ Y ++ P+ +D E
Sbjct 1208 TNIYSQNLC--VDGFGVNKIQPWTNDALNTICIKDADYNAKVEISVTPIKNTVDTTPKEE 1265
Query 1869 --IEPKLDGYYKKDNAYYTEQPIDLV 1892
++ KL+ + DN + + +D V
Sbjct 1266 FVVKEKLNAFLVHDNVAFYQGDVDTV 1291
>sp|P0C6X5|R1AB_CVHNL Replicase polyprotein 1ab OS=Human coronavirus
NL63 OX=277944 GN=rep PE=1 SV=1
Length=6729
Score = 1179 bits (3051), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 788/2330 (34%), Positives = 1207/2330 (52%), Gaps = 183/2330 (8%)
Query 2096 LKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQ 2155
L T+A I + S + P + I+ + AQ+ F + +V +
Sbjct 1858 LSTLAVTAIVVVGGCVTSNV-----PTIVSEKISVMDKLDTGAQKFFQ-FGDFVMNNIVL 1911
Query 2156 LCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKF---SKLFTIAM-WLL 2211
T+ S S +R T+I K+ +K +AK G+ +S K+ S LF I W +
Sbjct 1912 FLTWLLSMFSLLR----TSIMKHDIKVIAKAPKRTGVILTRSFKYNIRSALFVIKQKWCV 1967
Query 2212 LLSICLGSLICVTAAFGVLLSNFGAPS---YCNGVRELYLNSSNVTTMDFCEGSFPCSIC 2268
++++ L+ V + +P C + Y S+ + +C S C +C
Sbjct 1968 IVTLFKFLLLLYAIYALVFMIVQFSPFNSLLCGDIVSGYEKSTFNKDI-YCGNSMVCKMC 2026
Query 2269 LSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYML-FTKFFYLLGLSAIMQ 2325
L SY + T +K D ++ L +L +L F + GL +
Sbjct 2027 LF------SYQEFNDLDHTSLVWKHIRDPILISLQPFVILVILLIFGNMYLRFGLLYFVA 2080
Query 2326 VFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYY--IWKSYVHIMDGCTS 2383
F F S F+ WF+ P + F A+F I HI+ GC +
Sbjct 2081 QFISTFGS-FLGFHQKQWFL----HFVPFDVLCNE--FLATFIVCKIVLFVRHIIVGCNN 2133
Query 2384 STCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFIS 2443
+ C+ C K R RV TI+NGM +SFYV ANGG FC HN+ C+NCD+F G+TFI+
Sbjct 2134 ADCVACSKSARLKRVPLQTIINGMHKSFYVNANGGTCFCNKHNFFCVNCDSFGPGNTFIN 2193
Query 2444 DEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY---------FDKAGQKTYERHP 2494
++AR+L K + PT + I+D V NG LY FD K +
Sbjct 2194 GDIARELGNVVKTAVQPTAPAYVIIDKVDFVNGFYRLYSGDTFWRYDFDITESKYSCKEV 2253
Query 2495 LSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALV 2554
L + L+N N GS + + K+A VY+SQL+C+PI L++ L+
Sbjct 2254 LKNCNVLENFIVYNNSGS--------------NITQIKNACVYFSQLLCEPIKLVNSELL 2299
Query 2555 SDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAA 2614
S + S + + + AYVD +F ++L A ++ A + G+
Sbjct 2300 STL--SVDFNGVLHKAYVDVLCNSF---FKELTANMSMAECKATLGLT------------ 2342
Query 2615 RQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVEN-MTPRDLGACIDCNA 2673
V D + + +H D+ ++ S NNF ++Y K E+ ++ D+ C+ +
Sbjct 2343 --------VSDDDFVSAVANAHRYDVLLSDLSFNNFFISYAKPEDKLSVYDIACCMRAGS 2394
Query 2674 RHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITT 2733
+ +N V ++ ++W VKD+ +LS++ +K + K + F LT + + V T
Sbjct 2395 KVVNHNVLIKESIPIVWGVKDFNTLSQEGKKYLVKTTKAKGLTFLLTFNDNQAITQVPAT 2454
Query 2734 KISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGV 2793
I K G + + L V + + T++ GY +K I++G
Sbjct 2455 SIVAKQGAGFKRTYNFLWYVCLFVVALFIGVSFIDYTTTVTSFHGYD-----FKYIENGQ 2509
Query 2794 TRDIISTDDCFANKHAGFDAWFSQRGGSYK-NDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
+ + C N F+ W + G N CP+V + R +VPG+P V
Sbjct 2510 LKVFEAPLHCVRNVFDNFNQWHEAKFGVVTTNSDKCPIVVGVSERIN--VVPGVPTNVY- 2566
Query 2853 AINGDFLHFLPRVFSAVGN--ICYTPSKLIEYSDFATS-ACVLAAECTIFKDAMGKPVPY 2909
+ G L F + +A GN +CY ++ TS C+ + CT + G V Y
Sbjct 2567 -LVGKTLVFTLQ--AAFGNTGVCY------DFDGVTTSDKCIFNSACTRLEGLGGDNV-Y 2616
Query 2910 CYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCER 2968
CY+T+L+EGS YS L+P+ Y + ++FP G +R + T YCR G C
Sbjct 2617 CYNTDLIEGSKPYSTLQPNAYYKYDAKNYVRFPEILARGFGLRTIRTLATRYCRVGECRD 2676
Query 2969 SEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGG 3028
S G+C +W +N+ R G CG ++L+ N+ + + +S ++
Sbjct 2677 SHKGVCFGFD-KWYVNDG--RVDDGYICGDGLIDLLVNVLSIFSSSFSVVAMSGHMLFNF 2733
Query 3029 IIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILC--LVPAYSFLPG---VYS 3083
+ A +T + KF+RVFG+ ++ V FT++C L+ S++ +
Sbjct 2734 LFAAFITFLCFLVTKFKRVFGDLSYGV----------FTVVCATLINNISYVVTQNLFFM 2783
Query 3084 VFYLYLTFYFTNDV--SFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKR 3141
+ Y L F FT V +++ H+ + + ++P+W+ + F L+ N + +
Sbjct 2784 LLYAILYFVFTRTVRYAWIWHIAYIVAYFLLIPWWLLTWFSFAAFLE----LLPNVFKLK 2839
Query 3142 V---MFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
+ +F G F TFE AA TF+L+ Y +L + T+ P + Y A YNKYKY+SG+
Sbjct 2840 ISTQLFEGDKFIGTFESAAAGTFVLDMRSYERLIN-TISP-EKLKNYAASYNKYKYYSGS 2897
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
YR A HLAKA+ D++ D+LY PP S S LQSG +KMA PSG VE C+
Sbjct 2898 ASEADYRCACYAHLAKAMLDYAKDHNDMLYSPPTISYNST-LQSGLKKMAQPSGCVERCV 2956
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V+V G+T LNG+WL DTV CPRHVI + +L +Y+ H+F V V L V
Sbjct 2957 VRVCYGSTVLNGVWLGDTVTCPRHVIAPSTTVL-IDYDHAYSTMRLHNFSVSHNGVFLGV 3015
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+G +M +LR+KV SN TPK+ F ++PG +F++LACY G SGV+ +R N TIK
Sbjct 3016 VGVTMHGSVLRIKVSQSNVHTPKHVFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIK 3075
Query 3378 GSFLNGSCGSVGFNIDYD-CVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
GSF+NG+CGS G+N+ D V FCY+H +EL +G H G+D G YG F D+ + Q
Sbjct 3076 GSFINGACGSPGYNVRNDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESA 3135
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
+ ++ NV+A+LYAA++NG RW+L ++ FN AM Y ++ V+ L+A+
Sbjct 3136 NLMLSDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSS--VECYSILAAK 3193
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGT 3556
TG++V + A+++ L G G+ ILG + L DEFT +VV+Q GV Q K++ G
Sbjct 3194 TGVSVEQLLASIQHL-HEGFGGKNILGYSSLCDEFTLAEVVKQMYGVNLQSG--KVIFGL 3250
Query 3557 HHWMLLTFLTSLLILVQSTQWSLFFFVYENA-------FLPFTLGIMAIAACAMLLVKHK 3609
L + ++ W+ F +Y N P ++ ++ + +KHK
Sbjct 3251 KTMFLFSVFFTMF-------WAELF-IYTNTIWINPVILTPIFCLLLFLSLVLTMFLKHK 3302
Query 3610 HAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
FL +FLLP++ A +N V ++++ + + S+ ++ V L ++
Sbjct 3303 FLFLQVFLLPTVIATALYNCVL--DYYIVKFLADHFNYNVSVLQMDVQGLVNVLVCLFVV 3360
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
L T R + + ++I + Y +Y + M+ IS + Y G + +
Sbjct 3361 FLHTWRFSKERFTHWFTYVCSLIAVAYTYFYSGDFLSLLVMFLCAIS-SDWYIGAI--VF 3417
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
L+R IVF E +F ++ ++VY GY C Y+G+ NR+F+ T+GVYD
Sbjct 3418 RLSRLIVFFSPES---VFSVFGDVKLTLVVYLICGYLVCTYWGILYWFNRFFKCTMGVYD 3474
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
+ VS EF+YM + GL P DA L+ KLLGIGG CIK++TVQSK++D+KCT+VVL
Sbjct 3475 FKVSAAEFKYMVANGLHAPHGPFDALWLSFKLLGIGGDRCIKISTVQSKLTDLKCTNVVL 3534
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCE 3909
L L + + ++S WA CV LHN I L D +A +++LL+ LS ++ L +
Sbjct 3535 LGCLSSMNIAANSSEWAYCVDLHNKINLCDDPEKAQSMLLALLAFFLSKHSDFGLDGLID 3594
Query 3910 EMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFD 3969
DN +TLQ++AS F S+PSY AY A++AYE A+ANG S ++K+LK+++N+AKSEFD
Sbjct 3595 SYFDNSSTLQSVASSFVSMPSYIAYENARQAYEDAIANGSSSQLIKQLKRAMNIAKSEFD 3654
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
+ ++Q+K+ +MA+QA TQMYK+ARS ++++KV SAM ++LF MLR+LD ++ ++N A
Sbjct 3655 HEISVQKKINRMAEQAATQMYKEARSVNRKSKVISAMHSLLFGMLRRLDMSSVETVLNLA 3714
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTY-KNTCDGNTFTYASALWEIQQVVDADSKIVQL 4088
RDG VPL++IP T+A+KL +V PD +Y K CDG+ YA +W + V D D + V +
Sbjct 3715 RDGVVPLSVIPATSASKLTIVSPDLESYSKIVCDGSV-HYAGVVWTLNDVKDNDGRPVHV 3773
Query 4089 SEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAY 4148
EI +N L WPLI+ R VKLQNNE+ P L+Q A D NAL
Sbjct 3774 KEITKENVETLTWPLILNCER---VVKLQNNEIMPGKLKQKPMKAEGDGGVLGDGNAL-- 3828
Query 4149 YNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFI 4208
YN G F+ A +S+ DLK+ ++ G TI EL+ PCRF+ +TP GP+VKYLYF+
Sbjct 3829 YNTEGGKTFMYAYISNKADLKFVKWEYEGGCNTI--ELDSPCRFMVETPNGPQVKYLYFV 3886
Query 4209 KGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPI 4268
K LN L RG VLG + AT+RLQAG TE+ NS +L+ CAF+VDPA Y + + G +P+
Sbjct 3887 KNLNTLRRGAVLGFIGATIRLQAGKQTELAVNSGLLTACAFSVDPATTYLEAVKHGAKPV 3946
Query 4269 TNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQ 4328
+NC+KML G GQAIT + +AN +Q+S+GGAS CLYCR H+ HP+ G+C KGK VQ
Sbjct 3947 SNCIKMLSNGAGNGQAITTSVDANTNQDSYGGASICLYCRAHVPHPSMDGYCKFKGKCVQ 4006
Query 4329 IPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
+P C DP+ F L N VC VCG W G+GC+CD+ +QS D S +LN
Sbjct 4007 VPIGCL-DPIRFCLENNVCNVCGCWLGHGCACDR---TTIQSVDIS-YLN 4051
Score = 84.0 bits (206), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 62/179 (35%), Positives = 86/179 (48%), Gaps = 10/179 (6%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
NV DI + +VNAAN +L HGGGVA A++ T G +Q S DYI NGP
Sbjct 1265 NVKFYLGDISHLVNCVSFDFVVNAANENLLHGGGVARAIDILTEGQLQSLSKDYISSNGP 1324
Query 1075 LTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGA 1134
L VG +L +VVGP E L++A I L PLLS GIFG
Sbjct 1325 LKVGAGVMLECEKF--NVFNVVGPRTGKHEHSLLVEAYNSILFENGIPLMPLLSCGIFGV 1382
Query 1135 K---PLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLD--NLKPRVEAPKQEEPPNTE 1188
+ L++L C QV++ +++ EQ V+ +LD +L P ++ +P E
Sbjct 1383 RIENSLKALFSCDINKPLQVFVYSSNE---EQAVLKFLDGLDLTPVIDDVDVVKPFRVE 1438
Score = 52.0 bits (123), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 72/288 (25%), Positives = 119/288 (41%), Gaps = 28/288 (10%)
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLP-SDDTLRSEA 1608
T D N+ +V+ S + G+Q G DG D + EG VLP + DT+ S A
Sbjct 1587 TEDGINVKDVVVESSKSLGKQLGVVS-DGVD--------SFEG----VLPINTDTVLSVA 1633
Query 1609 FEYYHTLDESFLGRYMSALNHTKKWKFPQ--VGGLTSIKWADNNCYLSSVLLALQQLEVK 1666
E F + A K + +P VGG + DNNC++++ + LQ L+
Sbjct 1634 PEVDWVAFYGFEKAALFASLDVKPYGYPNDFVGGFRVLGTTDNNCWVNATCIILQYLKPT 1693
Query 1667 FNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN 1726
F + L + + GD F + I + + G+ GD E ++ L ++ L S V
Sbjct 1694 FKSKGLNVLWNKFVTGDVGPFVSFIYFITMSSKGQKGDAEEALSKLSEY--LISDSIVTL 1751
Query 1727 VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
C +T+ V++ + ++ LK G + R + V+ + V+++
Sbjct 1752 EQYSTCDICKSTVVEVKSAIVCASV----LKDGCDVGFCPHRHKLRSRVKFVNGRVVITN 1807
Query 1787 PPAEYKLQQGTFLCANEYT---GNYQCGHY-THITAKETLYRIDGAHL 1830
Q L YT G++ GHY + A +Y DGA L
Sbjct 1808 VGEPIISQPSKLLNGIAYTTFSGSFDNGHYVVYDAANNAVY--DGARL 1853
>sp|P0C6U6|R1A_CVHNL Replicase polyprotein 1a OS=Human coronavirus
NL63 OX=277944 GN=1a PE=1 SV=1
Length=4060
Score = 1178 bits (3047), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 788/2330 (34%), Positives = 1207/2330 (52%), Gaps = 183/2330 (8%)
Query 2096 LKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQ 2155
L T+A I + S + P + I+ + AQ+ F + +V +
Sbjct 1858 LSTLAVTAIVVVGGCVTSNV-----PTIVSEKISVMDKLDTGAQKFFQ-FGDFVMNNIVL 1911
Query 2156 LCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKF---SKLFTIAM-WLL 2211
T+ S S +R T+I K+ +K +AK G+ +S K+ S LF I W +
Sbjct 1912 FLTWLLSMFSLLR----TSIMKHDIKVIAKAPKRTGVILTRSFKYNIRSALFVIKQKWCV 1967
Query 2212 LLSICLGSLICVTAAFGVLLSNFGAPS---YCNGVRELYLNSSNVTTMDFCEGSFPCSIC 2268
++++ L+ V + +P C + Y S+ + +C S C +C
Sbjct 1968 IVTLFKFLLLLYAIYALVFMIVQFSPFNSLLCGDIVSGYEKSTFNKDI-YCGNSMVCKMC 2026
Query 2269 LSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYML-FTKFFYLLGLSAIMQ 2325
L SY + T +K D ++ L +L +L F + GL +
Sbjct 2027 LF------SYQEFNDLDHTSLVWKHIRDPILISLQPFVILVILLIFGNMYLRFGLLYFVA 2080
Query 2326 VFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYY--IWKSYVHIMDGCTS 2383
F F S F+ WF+ P + F A+F I HI+ GC +
Sbjct 2081 QFISTFGS-FLGFHQKQWFL----HFVPFDVLCNE--FLATFIVCKIVLFVRHIIVGCNN 2133
Query 2384 STCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFIS 2443
+ C+ C K R RV TI+NGM +SFYV ANGG FC HN+ C+NCD+F G+TFI+
Sbjct 2134 ADCVACSKSARLKRVPLQTIINGMHKSFYVNANGGTCFCNKHNFFCVNCDSFGPGNTFIN 2193
Query 2444 DEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY---------FDKAGQKTYERHP 2494
++AR+L K + PT + I+D V NG LY FD K +
Sbjct 2194 GDIARELGNVVKTAVQPTAPAYVIIDKVDFVNGFYRLYSGDTFWRYDFDITESKYSCKEV 2253
Query 2495 LSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALV 2554
L + L+N N GS + + K+A VY+SQL+C+PI L++ L+
Sbjct 2254 LKNCNVLENFIVYNNSGS--------------NITQIKNACVYFSQLLCEPIKLVNSELL 2299
Query 2555 SDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAA 2614
S + S + + + AYVD +F ++L A ++ A + G+
Sbjct 2300 STL--SVDFNGVLHKAYVDVLCNSF---FKELTANMSMAECKATLGLT------------ 2342
Query 2615 RQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVEN-MTPRDLGACIDCNA 2673
V D + + +H D+ ++ S NNF ++Y K E+ ++ D+ C+ +
Sbjct 2343 --------VSDDDFVSAVANAHRYDVLLSDLSFNNFFISYAKPEDKLSVYDIACCMRAGS 2394
Query 2674 RHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITT 2733
+ +N V ++ ++W VKD+ +LS++ +K + K + F LT + + V T
Sbjct 2395 KVVNHNVLIKESIPIVWGVKDFNTLSQEGKKYLVKTTKAKGLTFLLTFNDNQAITQVPAT 2454
Query 2734 KISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGV 2793
I K G + + L V + + T++ GY +K I++G
Sbjct 2455 SIVAKQGAGFKRTYNFLWYVCLFVVALFIGVSFIDYTTTVTSFHGYD-----FKYIENGQ 2509
Query 2794 TRDIISTDDCFANKHAGFDAWFSQRGGSYK-NDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
+ + C N F+ W + G N CP+V + R +VPG+P V
Sbjct 2510 LKVFEAPLHCVRNVFDNFNQWHEAKFGVVTTNSDKCPIVVGVSERIN--VVPGVPTNVY- 2566
Query 2853 AINGDFLHFLPRVFSAVGN--ICYTPSKLIEYSDFATS-ACVLAAECTIFKDAMGKPVPY 2909
+ G L F + +A GN +CY ++ TS C+ + CT + G V Y
Sbjct 2567 -LVGKTLVFTLQ--AAFGNTGVCY------DFDGVTTSDKCIFNSACTRLEGLGGDNV-Y 2616
Query 2910 CYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCER 2968
CY+T+L+EGS YS L+P+ Y + ++FP G +R + T YCR G C
Sbjct 2617 CYNTDLIEGSKPYSTLQPNAYYKYDAKNYVRFPEILARGFGLRTIRTLATRYCRVGECRD 2676
Query 2969 SEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGG 3028
S G+C +W +N+ R G CG ++L+ N+ + + +S ++
Sbjct 2677 SHKGVCFGFD-KWYVNDG--RVDDGYICGDGLIDLLVNVLSIFSSSFSVVAMSGHMLFNF 2733
Query 3029 IIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILC--LVPAYSFLPG---VYS 3083
+ A +T + KF+RVFG+ ++ V FT++C L+ S++ +
Sbjct 2734 LFAAFITFLCFLVTKFKRVFGDLSYGV----------FTVVCATLINNISYVVTQNLFFM 2783
Query 3084 VFYLYLTFYFTNDV--SFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKR 3141
+ Y L F FT V +++ H+ + + ++P+W+ + F L+ N + +
Sbjct 2784 LLYAILYFVFTRTVRYAWIWHIAYIVAYFLLIPWWLLTWFSFAAFLE----LLPNVFKLK 2839
Query 3142 V---MFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
+ +F G F TFE AA TF+L+ Y +L + T+ P + Y A YNKYKY+SG+
Sbjct 2840 ISTQLFEGDKFIGTFESAAAGTFVLDMRSYERLIN-TISP-EKLKNYAASYNKYKYYSGS 2897
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
YR A HLAKA+ D++ D+LY PP S S LQSG +KMA PSG VE C+
Sbjct 2898 ASEADYRCACYAHLAKAMLDYAKDHNDMLYSPPTISYNST-LQSGLKKMAQPSGCVERCV 2956
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V+V G+T LNG+WL DTV CPRHVI + +L +Y+ H+F V V L V
Sbjct 2957 VRVCYGSTVLNGVWLGDTVTCPRHVIAPSTTVL-IDYDHAYSTMRLHNFSVSHNGVFLGV 3015
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+G +M +LR+KV SN TPK+ F ++PG +F++LACY G SGV+ +R N TIK
Sbjct 3016 VGVTMHGSVLRIKVSQSNVHTPKHVFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIK 3075
Query 3378 GSFLNGSCGSVGFNIDYD-CVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGT 3436
GSF+NG+CGS G+N+ D V FCY+H +EL +G H G+D G YG F D+ + Q
Sbjct 3076 GSFINGACGSPGYNVRNDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESA 3135
Query 3437 DTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQ 3496
+ ++ NV+A+LYAA++NG RW+L ++ FN AM Y ++ V+ L+A+
Sbjct 3136 NLMLSDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSS--VECYSILAAK 3193
Query 3497 TGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGT 3556
TG++V + A+++ L G G+ ILG + L DEFT +VV+Q GV Q K++ G
Sbjct 3194 TGVSVEQLLASIQHL-HEGFGGKNILGYSSLCDEFTLAEVVKQMYGVNLQSG--KVIFGL 3250
Query 3557 HHWMLLTFLTSLLILVQSTQWSLFFFVYENA-------FLPFTLGIMAIAACAMLLVKHK 3609
L + ++ W+ F +Y N P ++ ++ + +KHK
Sbjct 3251 KTMFLFSVFFTMF-------WAELF-IYTNTIWINPVILTPIFCLLLFLSLVLTMFLKHK 3302
Query 3610 HAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
FL +FLLP++ A +N V ++++ + + S+ ++ V L ++
Sbjct 3303 FLFLQVFLLPTVIATALYNCVL--DYYIVKFLADHFNYNVSVLQMDVQGLVNVLVCLFVV 3360
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
L T R + + ++I + Y +Y + M+ IS + Y G + +
Sbjct 3361 FLHTWRFSKERFTHWFTYVCSLIAVAYTYFYSGDFLSLLVMFLCAIS-SDWYIGAI--VF 3417
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
L+R IVF E +F ++ ++VY GY C Y+G+ NR+F+ T+GVYD
Sbjct 3418 RLSRLIVFFSPES---VFSVFGDVKLTLVVYLICGYLVCTYWGILYWFNRFFKCTMGVYD 3474
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
+ VS EF+YM + GL P DA L+ KLLGIGG CIK++TVQSK++D+KCT+VVL
Sbjct 3475 FKVSAAEFKYMVANGLHAPHGPFDALWLSFKLLGIGGDRCIKISTVQSKLTDLKCTNVVL 3534
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCE 3909
L L + + ++S WA CV LHN I L D +A +++LL+ LS ++ L +
Sbjct 3535 LGCLSSMNIAANSSEWAYCVDLHNKINLCDDPEKAQSMLLALLAFFLSKHSDFGLDGLID 3594
Query 3910 EMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFD 3969
DN +TLQ++AS F S+PSY AY A++AYE A+ANG S ++K+LK+++N+AKSEFD
Sbjct 3595 SYFDNSSTLQSVASSFVSMPSYIAYENARQAYEDAIANGSSSQLIKQLKRAMNIAKSEFD 3654
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
+ ++Q+K+ +MA+QA TQMYK+ARS ++++KV SAM ++LF MLR+LD ++ ++N A
Sbjct 3655 HEISVQKKINRMAEQAATQMYKEARSVNRKSKVISAMHSLLFGMLRRLDMSSVETVLNLA 3714
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTY-KNTCDGNTFTYASALWEIQQVVDADSKIVQL 4088
RDG VPL++IP T+A+KL +V PD +Y K CDG+ YA +W + V D D + V +
Sbjct 3715 RDGVVPLSVIPATSASKLTIVSPDLESYSKIVCDGSV-HYAGVVWTLNDVKDNDGRPVHV 3773
Query 4089 SEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAY 4148
EI +N L WPLI+ R VKLQNNE+ P L+Q A D NAL
Sbjct 3774 KEITKENVETLTWPLILNCER---VVKLQNNEIMPGKLKQKPMKAEGDGGVLGDGNAL-- 3828
Query 4149 YNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFI 4208
YN G F+ A +S+ DLK+ ++ G TI EL+ PCRF+ +TP GP+VKYLYF+
Sbjct 3829 YNTEGGKTFMYAYISNKADLKFVKWEYEGGCNTI--ELDSPCRFMVETPNGPQVKYLYFV 3886
Query 4209 KGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPI 4268
K LN L RG VLG + AT+RLQAG TE+ NS +L+ CAF+VDPA Y + + G +P+
Sbjct 3887 KNLNTLRRGAVLGFIGATIRLQAGKQTELAVNSGLLTACAFSVDPATTYLEAVKHGAKPV 3946
Query 4269 TNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQ 4328
+NC+KML G GQAIT + +AN +Q+S+GGAS CLYCR H+ HP+ G+C KGK VQ
Sbjct 3947 SNCIKMLSNGAGNGQAITTSVDANTNQDSYGGASICLYCRAHVPHPSMDGYCKFKGKCVQ 4006
Query 4329 IPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
+P C DP+ F L N VC VCG W G+GC+CD+ +QS D S +LN
Sbjct 4007 VPIGCL-DPIRFCLENNVCNVCGCWLGHGCACDR---TTIQSVDIS-YLN 4051
Score = 84.0 bits (206), Expect = 4e-14, Method: Compositional matrix adjust.
Identities = 62/179 (35%), Positives = 86/179 (48%), Gaps = 10/179 (6%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
NV DI + +VNAAN +L HGGGVA A++ T G +Q S DYI NGP
Sbjct 1265 NVKFYLGDISHLVNCVSFDFVVNAANENLLHGGGVARAIDILTEGQLQSLSKDYISSNGP 1324
Query 1075 LTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGA 1134
L VG +L +VVGP E L++A I L PLLS GIFG
Sbjct 1325 LKVGAGVMLECEKF--NVFNVVGPRTGKHEHSLLVEAYNSILFENGIPLMPLLSCGIFGV 1382
Query 1135 K---PLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLD--NLKPRVEAPKQEEPPNTE 1188
+ L++L C QV++ +++ EQ V+ +LD +L P ++ +P E
Sbjct 1383 RIENSLKALFSCDINKPLQVFVYSSNE---EQAVLKFLDGLDLTPVIDDVDVVKPFRVE 1438
Score = 52.4 bits (124), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 72/288 (25%), Positives = 119/288 (41%), Gaps = 28/288 (10%)
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLP-SDDTLRSEA 1608
T D N+ +V+ S + G+Q G DG D + EG VLP + DT+ S A
Sbjct 1587 TEDGINVKDVVVESSKSLGKQLGVVS-DGVD--------SFEG----VLPINTDTVLSVA 1633
Query 1609 FEYYHTLDESFLGRYMSALNHTKKWKFPQ--VGGLTSIKWADNNCYLSSVLLALQQLEVK 1666
E F + A K + +P VGG + DNNC++++ + LQ L+
Sbjct 1634 PEVDWVAFYGFEKAALFASLDVKPYGYPNDFVGGFRVLGTTDNNCWVNATCIILQYLKPT 1693
Query 1667 FNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN 1726
F + L + + GD F + I + + G+ GD E ++ L ++ L S V
Sbjct 1694 FKSKGLNVLWNKFVTGDVGPFVSFIYFITMSSKGQKGDAEEALSKLSEY--LISDSIVTL 1751
Query 1727 VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
C +T+ V++ + ++ LK G + R + V+ + V+++
Sbjct 1752 EQYSTCDICKSTVVEVKSAIVCASV----LKDGCDVGFCPHRHKLRSRVKFVNGRVVITN 1807
Query 1787 PPAEYKLQQGTFLCANEYT---GNYQCGHY-THITAKETLYRIDGAHL 1830
Q L YT G++ GHY + A +Y DGA L
Sbjct 1808 VGEPIISQPSKLLNGIAYTTFSGSFDNGHYVVYDAANNAVY--DGARL 1853
Score = 36.2 bits (82), Expect = 9.6, Method: Compositional matrix adjust.
Identities = 46/215 (21%), Positives = 87/215 (40%), Gaps = 18/215 (8%)
Query 1601 DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL 1660
DD++R E +E ++ ++ + F G+ + +DNNC++S+ L+ L
Sbjct 1015 DDSVREEVDIIEQPFEEV---EHVLSIKQPFSFSFRDELGVRVLDQSDNNCWISTTLVQL 1071
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES 1720
Q ++ ++ +Q + G + S+ G LGD + ++ LL+ +
Sbjct 1072 QLTKLLDDSIEMQ----LFKVGKVDSIVQKCYELSHLISGSLGDSGKLLSELLKEK--YT 1125
Query 1721 AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNL-KTGVSIPCVCGRDATQYLVQQES 1779
+ C CG+K G + Y L + G C+C + T LV +
Sbjct 1126 CSITFEMSCD-CGKKFDDQVGC----LFWIMPYTKLFQKGEC--CICHKMQTYKLVSMKG 1178
Query 1780 SFVMMSAP-PAEYKLQQGTFLCANEYTGNYQCGHY 1813
+ V + P P + +C++ Y G GHY
Sbjct 1179 TGVFVQDPAPIDIDAFPVKPICSSVYLGVKGSGHY 1213
>sp|Q98VG9|R1AB_FIPV Replicase polyprotein 1ab OS=Feline coronavirus
(strain FIPV WSU-79/1146) OX=33734 GN=rep PE=1 SV=2
Length=6709
Score = 1120 bits (2896), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 730/2188 (33%), Positives = 1118/2188 (51%), Gaps = 149/2188 (7%)
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILG 2299
C+G + Y NSS V + + C S C CL+ D L + L+ YK D
Sbjct 1946 CSGSVQAYSNSSFVKS-EVCGNSILCKACLASYDELADFDHLQVSW----DYKSDPLWNR 2000
Query 2300 LAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWF-------IISIVQMA 2352
+ L+Y +F F + ++ YF S ++ N WL +F + +V
Sbjct 2001 VIQ---LSYFIFLAVFG----NNYVRCLLMYFVSQYL-NLWLSYFGYVKYSWFLHVVNFE 2052
Query 2353 PVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFY 2412
+S + + K HI C + +C C K R TR+ +VNG ++ Y
Sbjct 2053 SISVEFVIIVVVFKAVLALK---HIFLPCNNPSCKTCSKIARQTRIPIQVVVNGSMKTVY 2109
Query 2413 VYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVA 2472
V+ANG CK HN+ C NCD++ TFI DE+ RDLS K+ + TD+S V V
Sbjct 2110 VHANGTGKLCKKHNFYCKNCDSYGFDHTFICDEIVRDLSNSIKQTVYATDRSYQEVTKVE 2169
Query 2473 VKNGALHLY---------FDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+G Y +D +K + L LD+ N GS +V
Sbjct 2170 CTDGFYRFYVGEEFTAYDYDVKHKKYSSQEVLKTMFLLDDFIVYNPSGSSLASV------ 2223
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
++ VY+SQL+ +PI +++ L+ D+ S + +F+A + +F+V +
Sbjct 2224 --------RNVCVYFSQLIGRPIKIVNSELLEDL--SVDFKGALFNAKKNVIKNSFNVDV 2273
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVT 2643
+ K L E K LD STF A +H + +T
Sbjct 2274 SECKNL-----EECYKLCNLDVTFSTFEMAINN------------------AHRFGILIT 2310
Query 2644 GDSCNNFMLTYNK--VENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQ 2701
S NNF + K ++ D+G C+ +A+ +NA+V S++W +D+ +LS
Sbjct 2311 DRSFNNFWPSKIKPGSSGVSAMDIGKCMTFDAKIVNAKVLTQRGKSVVWLSQDFSTLSST 2370
Query 2702 LRKQIRSAAKKNNIPFRLTCATTRQVVNV----ITTKISLKGGKIVSTCFKLMLKATLLC 2757
+K + + + F LT ++ T +S K G K LK C
Sbjct 2371 AQKVLVKTFVEEGVNFSLTFNAVGSDEDLPYERFTESVSAKSGSGFFDVLK-QLKQLFWC 2429
Query 2758 VLAALVCYIVMPVHTLSIHDGYTNEIIGYK--AIQDGVTRDIISTDDCFANKHAGFDAWF 2815
++ + Y + V++++ Y + GY I++GV + + +C N + GF WF
Sbjct 2430 LVLFITLYGLCSVYSVATQ-SYIDSAEGYDYMVIKNGVVQSFDDSINCVHNTYKGFAVWF 2488
Query 2816 SQRGGSYKN-DKSCPVVAAIITREIGFI--VPGLPGTVLRAINGDFLHFLPRVFSAVGNI 2872
+ G DKSCP+V + ++G + +P +P V A+ G L F V N+
Sbjct 2489 KAKHGFVPTFDKSCPIVLGTVF-DLGNMRPIPDVPAYV--ALVGRSLVFAINAAFGVTNV 2545
Query 2873 CY--TPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTR 2930
CY T + + + S F T CV + CT +G V YC L+EG+ YSEL PD
Sbjct 2546 CYDHTGAAVSKNSYFDT--CVFNSACTTLT-GIGGTVVYCAKQGLVEGAKLYSELLPDYY 2602
Query 2931 YVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRA 2990
Y G++++ P +R V T YCR G C S+ G C +V + E
Sbjct 2603 YEHASGNMVKIPAIIRSFGLRFVKTQATTYCRVGECTESQAGFCFGGDNWFVYDKEFG-- 2660
Query 2991 LSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGE 3050
G CG + N+F + + S +++A +IA L Y +KF+++FG+
Sbjct 2661 -DGYICGSSTLGFFKNVFALFNSNMSVVATSGAMLANIVIACLAIAVCYGVLKFKKIFGD 2719
Query 3051 YNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAM 3108
+V ++ L+ + V +F VY++ Y ++ T +++ L +
Sbjct 2720 CTLLVVM-IIVTLVVNNVSYFVTQNTFFMIVYAIIY----YFTTRKLAYPGVLDAGFIIA 2774
Query 3109 FSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMY 3167
+ + P+++ +Y+ F + +F G F +FE AA+ TF+++ Y
Sbjct 2775 YLNMAPWYVLVLYIMVFLYDSLPSLFKLKVTTN-LFEGDKFVGSFESAAMGTFVIDMRSY 2833
Query 3168 LKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLY 3227
L + T L + Y +NKYKY++G++ YR A HL KAL D+S S D+LY
Sbjct 2834 ETLVNST--SLDRIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYSVSRNDMLY 2891
Query 3228 QPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAE 3287
PP S+ S LQSG RKMA PSG VE C+V+V G LNGLWL D V CPRHVI +
Sbjct 2892 TPPTVSVNST-LQSGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDT 2950
Query 3288 DMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQ 3347
+ NYE+ L H+F + N L V+ + L LKV+ NP TP++KF ++
Sbjct 2951 SRV-INYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPEHKFKSVR 3009
Query 3348 PGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMEL 3407
PG++F++LACY G P VY MR TIKGSF+ G+CGSVG+ ++ + F YMHH+EL
Sbjct 3010 PGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGTLYFVYMHHLEL 3069
Query 3408 PTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTL 3467
G H G++LEG+ YG + D+ + Q GT+ + NV+A+LYAA+ING+RWF+ + TL
Sbjct 3070 GNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGERWFVTNTSMTL 3129
Query 3468 NDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTIL 3527
+N A ++ + D L+A+TG +V + + L G GRTIL L
Sbjct 3130 ESYNAWAKTNSFTEIVS--TDAFNMLAAKTGYSVEKLLECIVRL-NKGFGGRTILSYGSL 3186
Query 3528 EDEFTPFDVVRQCSGVTFQ-GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFF----F 3582
DEFTP +V+RQ GV Q GK K I +T++ IL W FF F
Sbjct 3187 CDEFTPTEVIRQMYGVNLQSGKVKSI--------FYPMMTAIAILFAF--WLEFFMYTPF 3236
Query 3583 VYEN-AFLPFTLGIMAIAACAMLL-VKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRI 3640
+ N F+ L I + + ++ +KHK F F++PS+ N+V+ ++ +
Sbjct 3237 TWINPTFVSVVLAITTLVSVLLVAGIKHKMLFFMSFVMPSVILATAHNVVW-DMTYYESL 3295
Query 3641 MTWLELADTSLSGYRLKDCVMYASALVLLILMTAR------TVYDDAARRVWTLMNVITL 3694
+E +T+ ++ ++ +V+ ++ T R + + A ++ + N++ L
Sbjct 3296 QVLVENVNTTFLPVDMQGVMLALFCVVVFVICTIRFFTCKQSWFSLFATTIFVMFNIVKL 3355
Query 3695 VYKVYYGNALDQ----AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
+ + D ++M ++IS+T+ VV +A IV ++ P
Sbjct 3356 LGMIGEPWTDDHFLLCLVNMLTMLISLTTKDWFVVFASYKVAYYIVVYVMQ--PAFVQDF 3413
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKS 3810
++C+ ++Y GY CCY+G+ +NR+ +T GVY + VS E +YM + L PK+
Sbjct 3414 GFVKCVSIIYMACGYLFCCYYGILYWVNRFTCMTCGVYQFTVSPAELKYMTANNLSAPKT 3473
Query 3811 SIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3870
+ DA L+ KL+GIGG IK++TVQSK++++KCT+VVLL +L ++ VES+SK W CV
Sbjct 3474 AYDAMILSFKLMGIGGGRNIKISTVQSKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVG 3533
Query 3871 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPS 3930
LHN+I L D EK+++L++ LS D++ L E +N LQ++AS +++LPS
Sbjct 3534 LHNEINLCDDPDAVLEKLLALIAFFLSKHNTCDLSDLIESYFENTTILQSVASAYAALPS 3593
Query 3931 YAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 3990
+ AY A+ E+A N S +LK+L K+ N+AKSEF+R+A++Q+KL+KMA+QA MY
Sbjct 3594 WIAYEKARADLEEAKKNDVSPQLLKQLTKACNIAKSEFEREASVQKKLDKMAEQAAASMY 3653
Query 3991 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4050
K+AR+ D+++K+ SAM ++LF ML+KLD ++N II AR+G +PL+IIP +A +L+VV
Sbjct 3654 KEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIEQARNGVLPLSIIPAASATRLIVV 3713
Query 4051 VPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRA 4110
P+ N YA A+W I +V DA+ V L E+ N N+ WPL +T R
Sbjct 3714 TPNLEVLSKVRQENNVHYAGAIWSIVEVKDANGAQVHLKEVTAANELNITWPLSITCER- 3772
Query 4111 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKW 4170
KLQNNE+ P L++ + A T + A + G F+ A ++ +LK+
Sbjct 3773 --TTKLQNNEILPGKLKEKAVKASATIDGDAYGSGKALMASEGGKSFIYAFIASDSNLKY 3830
Query 4171 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4230
++ ++ I ELE P RF D GP+VKYLYF+K LN L RG VLG + ATVRLQ
Sbjct 3831 VKWESNN--DVIPIELEAPLRFYVDGVNGPEVKYLYFVKSLNTLRRGAVLGYIGATVRLQ 3888
Query 4231 AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
AG TE P+NS +L+ CAFA DPAKAY D + G QP+TNCVKML G G AIT E
Sbjct 3889 AGKPTEHPSNSGLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKMLSNGAGNGMAITNGVE 3948
Query 4291 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVC 4350
+N Q+S+GGAS C+YCRCH++HP G C KGK+VQ+PT DP+ F + N VC VC
Sbjct 3949 SNTQQDSYGGASVCIYCRCHVEHPAIDGLCRFKGKFVQVPTG-TQDPIRFCIENEVCVVC 4007
Query 4351 GMWKGYGCSCDQLREPLMQSADASTFLN 4378
G W GC CD R + + ++LN
Sbjct 4008 GCWLTNGCMCD--RTSIQGTTIDQSYLN 4033
Score = 59.3 bits (142), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 42/117 (36%), Positives = 58/117 (50%), Gaps = 1/117 (1%)
Query 1032 PMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK 1091
P V+VNAAN L+H GGVA A++ T G + K S +Y+K + + G + L
Sbjct 1358 PDVLVNAANGDLRHVGGVARAIDVFTGGKLTKRSKEYLKSSKAIAPGNAVLFENVLEHLS 1417
Query 1092 CLHVVGPNLNAGEDIQLLKAAYENFNSQD-ILLAPLLSAGIFGAKPLQSLQVCVQTV 1147
L+ VGP L Y+ D +L PL+S GIF K SLQ ++TV
Sbjct 1418 VLNAVGPRNGDSRVEGKLCNVYKAIAKCDGKILTPLISVGIFKVKLEVSLQCLLKTV 1474
Score = 51.6 bits (122), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 71/285 (25%), Positives = 111/285 (39%), Gaps = 27/285 (9%)
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
TI + T D N V + TYG+Q G + DVT P V+ G+
Sbjct 1499 TIPIKVTEDTVNQKRVSVALDKTYGEQLKGTVVIKDKDVTNQLPSVSDVGEKVV-----K 1553
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSI--KWADNNCYLSSVLLAL 1660
L + YY + + SA +H ++F V I K DNNC+++++ LAL
Sbjct 1554 ALDVDWNAYYGFPNAAAF----SASSH-DAYEFDVVTHNNFIVHKQTDNNCWVNAICLAL 1608
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES 1720
Q+L+ + P ++ + A F ++ S T G+ GD T+ L+ + +S
Sbjct 1609 QRLKPTWKFPGVKSLWDAFLTRKTAGFVHMLYHISGLTKGQPGDAELTLHKLVDLMSSDS 1668
Query 1721 AKRVLN-VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQES 1779
A V + C C K T TG + L G CV G +
Sbjct 1669 AVTVTHTTACDKCA-KVETFTGPVVAAPL-------LVCGTDEICVHGVHVNVKVTSIRG 1720
Query 1780 SFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETL 1822
+ + S P + ++C YTG GHYT+ + L
Sbjct 1721 TVAITSLIGPVVGDVIDATGYIC---YTGLNSRGHYTYYDNRNGL 1762
>sp|P0C6V2|R1A_CVPPU Replicase polyprotein 1a OS=Porcine transmissible
gastroenteritis coronavirus (strain Purdue) OX=11151
GN=1a PE=1 SV=1
Length=4017
Score = 1113 bits (2880), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 720/2176 (33%), Positives = 1108/2176 (51%), Gaps = 155/2176 (7%)
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILG 2299
CNG + Y NSS + + C S C CL+ D L + + +QVT +K D
Sbjct 1921 CNGAVQAYKNSSFIKSA-VCGNSILCKACLASYDELADF---QHLQVTWD-FKSDPLWNR 1975
Query 2300 LAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWF-------IISIVQMA 2352
L L+Y F F + ++ F YF S ++ N WL +F + +V
Sbjct 1976 LVQ---LSYFAFLAVFG----NNYVRCFLMYFVSQYL-NLWLSYFGYVEYSWFLHVVNFE 2027
Query 2353 PVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFY 2412
+SA + + K HI+ C++ +C C + R TR+ +VNG ++ Y
Sbjct 2028 SISAEFVIVVIVVKAVLALK---HIVFACSNPSCKTCSRTARQTRIPIQVVVNGSMKTVY 2084
Query 2413 VYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVA 2472
V+ANG FCK HN+ C NCD++ +TFI DE+ RDLS K+ + TD+S V V
Sbjct 2085 VHANGTGKFCKKHNFYCKNCDSYGFENTFICDEIVRDLSNSVKQTVYATDRSHQEVTKVE 2144
Query 2473 VKNGALHLY---------FDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+G Y +D +K + L + LD+ + GS NV
Sbjct 2145 CSDGFYRFYVGDEFTSYDYDVKHKKYSSQEVLKSMLLLDDFIVYSPSGSALANV------ 2198
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
++A VY+SQL+ +PI +++ L+ D+ S + +F+A + +F+V +
Sbjct 2199 --------RNACVYFSQLIGKPIKIVNSDLLEDL--SVDFKGALFNAKKNVIKNSFNVDV 2248
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVT 2643
+ K L E + L+ STF A +H + +T
Sbjct 2249 SECKNL-----DECYRACNLNVSFSTFEMAVNN------------------AHRFGILIT 2285
Query 2644 GDSCNNFMLTYNK--VENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQ 2701
S NNF + K ++ D+G C+ +A+ +NA+V S++W +D+ +LS
Sbjct 2286 DRSFNNFWPSKVKPGSSGVSAMDIGKCMTSDAKIVNAKVLTQRGKSVVWLSQDFAALSST 2345
Query 2702 LRKQIRSAAKKNNIPFRLTCATTRQVVNV----ITTKISLKGGKIVSTCFKLMLKATLLC 2757
+K + + + F LT ++ T +S K G + + +L
Sbjct 2346 AQKVLVKTFVEEGVNFSLTFNAVGSDDDLPYERFTESVSPKSGSGFFDVITQLKQIVILV 2405
Query 2758 VLAALVC-----YIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFD 2812
+ +C Y V + +GY Y I++G+ + T C N + GF
Sbjct 2406 FVFIFICGLCSVYSVATQSYIESAEGYD-----YMVIKNGIVQPFDDTISCVHNTYKGFG 2460
Query 2813 AWFSQRGGSYKN-DKSCP-VVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVG 2870
WF + G KSCP VV + E +P +P V +I G L F V
Sbjct 2461 DWFKAKYGFIPTFGKSCPIVVGTVFDLENMRPIPDVPAYV--SIVGRSLVFAINAAFGVT 2518
Query 2871 NICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTR 2930
N+CY + D CV CT +G + YC L+EG+ YS+L PD
Sbjct 2519 NMCYDHTGNAVSKDSYFDTCVFNTACTTLT-GLGGTIVYCAKQGLVEGAKLYSDLMPDYY 2577
Query 2931 YVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRA 2990
Y G++++ P +R V T YCR G C S+ G C +V +NE
Sbjct 2578 YEHASGNMVKLPAIIRGLGLRFVKTQATTYCRVGECIDSKAGFCFGGDNWFVYDNEFG-- 2635
Query 2991 LSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGE 3050
+G CG + N+F + + S +++ IIA L Y +KF+++FG+
Sbjct 2636 -NGYICGNSVLGFFKNVFKLFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGD 2694
Query 3051 YNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAM 3108
++ ++ L+ + V +F +Y++ Y ++ T +++ L +
Sbjct 2695 CTFLIVM-IIVTLVVNNVSYFVTQNTFFMIIYAIVY----YFITRKLAYPGILDAGFIIA 2749
Query 3109 FSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMY 3167
+ + P+++ Y+ F + +F G F FE AA+ TF+++ Y
Sbjct 2750 YINMAPWYVITAYILVFLYDSLPSLFKLKVSTN-LFEGDKFVGNFESAAMGTFVIDMRSY 2808
Query 3168 LKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLY 3227
+ + T + + Y +NKYKY++G++ YR A HL KAL D+S + D+LY
Sbjct 2809 ETIVNST--SIARIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYSVNRTDMLY 2866
Query 3228 QPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAE 3287
PP S+ S LQSG RKMA PSG VE C+V+V+ G LNGLWL D V CPRHVI +
Sbjct 2867 TPPTVSVNST-LQSGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDT 2925
Query 3288 DMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQ 3347
+ NYE+ + H+F V NV L V+ + L LKV+ NP TP++KF I+
Sbjct 2926 TRV-INYENEMSSVRLHNFSVSKNNVFLGVVSARYKGVNLVLKVNQVNPNTPEHKFKSIK 2984
Query 3348 PGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMEL 3407
G++F++LACY G P VY MR TIKGSF+ G+CGSVG+ ++ + F YMHH+EL
Sbjct 2985 AGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLEL 3044
Query 3408 PTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTL 3467
G H G++ EG+ YG + D+ + Q GT+ + NV+A+LYAA+ING+RWF+ + +L
Sbjct 3045 GNGSHVGSNFEGEMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGERWFVTNTSMSL 3104
Query 3468 NDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTIL 3527
+N A ++ L+ D L+A+TG +V + ++ L G GRTIL L
Sbjct 3105 ESYNTWAKTNSFTELSS--TDAFSMLAAKTGQSVEKLLDSIVRL-NKGFGGRTILSYGSL 3161
Query 3528 EDEFTPFDVVRQCSGVTFQ-GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFF----F 3582
DEFTP +V+RQ GV Q GK K + + ++T +T L W FF F
Sbjct 3162 CDEFTPTEVIRQMYGVNLQAGKVK-----SFFYPIMTAMTILFAF-----WLEFFMYTPF 3211
Query 3583 VYEN-AFLPFTLGIMAIAACAMLL-VKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRI 3640
+ N F+ L + + + + +KHK F F+LPS+ V N+ + S+ +
Sbjct 3212 TWINPTFVSIVLAVTTLISTVFVSGIKHKMLFFMSFVLPSVILVTAHNL-FWDFSYYESL 3270
Query 3641 MTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY---K 3697
+ +E +T ++ ++ ++ + + R ++ W + V T++
Sbjct 3271 QSIVENTNTMFLPVDMQGVMLTVFCFIVFVTYSVRFF---TCKQSWFSLAVTTILVIFNM 3327
Query 3698 VYYGNALDQA----------ISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLF 3747
V D+ ++M +++S+T+ VV +A IV VCV P F
Sbjct 3328 VKIFGTSDEPWTENQIAFCFVNMLTMIVSLTTKDWMVVIASYRIAYYIV-VCV--MPSAF 3384
Query 3748 ITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLL 3806
++ ++CI +VY GY CCY+G+ +NR+ +T GVY + VS E +YM + L
Sbjct 3385 VSDFGFMKCISIVYMACGYLFCCYYGILYWVNRFTCMTCGVYQFTVSAAELKYMTANNLS 3444
Query 3807 PPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWA 3866
PK++ DA L+ KL+G+GGK IK++TVQSK++++KCT+VVLL +L ++ VES+SK W
Sbjct 3445 APKNAYDAMILSAKLIGVGGKRNIKISTVQSKLTEMKCTNVVLLGLLSKMHVESNSKEWN 3504
Query 3867 QCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFS 3926
CV LHN+I L D EK+++L++ LS D++ L E +N LQ++AS ++
Sbjct 3505 YCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCDLSELIESYFENTTILQSVASAYA 3564
Query 3927 SLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAM 3986
+LPS+ A A+ E+A N S +LK+L K+ N+AKS+F+R+A++Q+KL+KMA+QA
Sbjct 3565 ALPSWIALEKARADLEEAKKNDVSPQILKQLTKAFNIAKSDFEREASVQKKLDKMAEQAA 3624
Query 3987 TQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAK 4046
MYK+AR+ D+++K+ SAM ++LF ML+KLD ++N II+ AR+G +PL+IIP +A +
Sbjct 3625 ASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIDQARNGVLPLSIIPAASATR 3684
Query 4047 LMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVT 4106
L+V+ P + N YA A+W I +V DA+ V L E+ N NL WPL +T
Sbjct 3685 LVVITPSLEVFSKIRQENNVHYAGAIWTIVEVKDANGSHVHLKEVTAANELNLTWPLSIT 3744
Query 4107 ALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQ 4166
R KLQNNE+ P L++ + A T + A + G F+ A ++
Sbjct 3745 CER---TTKLQNNEIMPGKLKERAVRASATLDGEAFGSGKALMASESGKSFMYAFIASDN 3801
Query 4167 DLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAAT 4226
+LK+ ++ ++ I ELE P RF D GP+VKYLYF+K LN L RG VLG + AT
Sbjct 3802 NLKYVKWESNN--DIIPIELEAPLRFYVDGANGPEVKYLYFVKNLNTLRRGAVLGYIGAT 3859
Query 4227 VRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAIT 4286
VRLQAG TE P+NS++L+ CAF+ DPAKAY D + G QP+ NCVKML G G A+T
Sbjct 3860 VRLQAGKPTEHPSNSSLLTLCAFSPDPAKAYVDAVKRGMQPVNNCVKMLSNGAGNGMAVT 3919
Query 4287 VTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTV 4346
EAN Q+S+GGAS C+YCRCH++HP G C KGK+VQIPT DP+ F + N V
Sbjct 3920 NGVEANTQQDSYGGASVCIYCRCHVEHPAIDGLCRYKGKFVQIPTG-TQDPIRFCIENEV 3978
Query 4347 CTVCGMWKGYGCSCDQ 4362
C VCG W GC CD+
Sbjct 3979 CVVCGCWLNNGCMCDR 3994
Score = 65.5 bits (158), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 72/276 (26%), Positives = 118/276 (43%), Gaps = 28/276 (10%)
Query 969 ETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQF--TGYLKLTDNVAIKCVDIVKE 1026
+ +VE+ E++ +++ E E P ++ + F G L ++ ++
Sbjct 1288 QEFKVEKVEQQPIVEENKSSIEKEEIQSPKNDDLILPFYKAGKLSFYQGALDVLINFLE- 1346
Query 1027 AQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGH 1086
P VIVNAAN LKH GGVA A++ T G + + S DY+K N + G +
Sbjct 1347 -----PDVIVNAANGDLKHMGGVARAIDVFTGGKLTERSKDYLKKNKSIAPGNAVFFENV 1401
Query 1087 NLAKKCLHVVGP-NLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQ 1145
L+ VGP N ++ + +L + +L PL+S GIF + SLQ ++
Sbjct 1402 IEHLSVLNAVGPRNGDSRVEAKLCNVYKAIAKCEGKILTPLISVGIFNVRLETSLQCLLK 1461
Query 1146 TVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP--NTEDSKTEEKSVVQKPVD 1203
T VND+ L V Y D + +E P TED+ E+ V
Sbjct 1462 T--------VNDRGLN---VFVYTDQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKT 1510
Query 1204 VKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKL 1239
++K T + + K +TN+L D+ K+
Sbjct 1511 YGEQLKG------TVVIKDKDVTNQLPSAFDVGQKV 1540
Score = 47.4 bits (111), Expect = 0.005, Method: Compositional matrix adjust.
Identities = 71/287 (25%), Positives = 115/287 (40%), Gaps = 31/287 (11%)
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
+I V T DN N V TYG+Q G + DVT P G+ V+ + D
Sbjct 1488 SIPVNVTEDNVNHERVSVSFDKTYGEQLKGTVVIKDKDVTNQLPSAFDVGQK--VIKAID 1545
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSI--KWADNNCYLSSVLLAL 1660
+ +Y D + SA +H +KF V I K DNNC+++++ LAL
Sbjct 1546 I---DWQAHYGFRDAAAF----SASSH-DAYKFEVVTHSNFIVHKQTDNNCWINAICLAL 1597
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES 1720
Q+L+ ++ P ++ + F ++ S GE GD E M H L
Sbjct 1598 QRLKPQWKFPGVRGLWNEFLERKTQGFVHMLYHISGVKKGEPGDA-ELMLHKLGDLMDND 1656
Query 1721 AKRVL--NVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKT-GVSIPCVCGRDATQYLVQQ 1777
+ ++ C C + VE ++G + L G CV G + Q
Sbjct 1657 CEIIVTHTTACDKCAK-------VEK--FVGPVVAAPLAIHGTDETCVHGVSVNVKVTQI 1707
Query 1778 ESSFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETL 1822
+ + + S P L+ ++C Y+G+ + GHYT+ + L
Sbjct 1708 KGTVAITSLIGPIIGEVLEATGYIC---YSGSNRNGHYTYYDNRNGL 1751
Score = 45.1 bits (105), Expect = 0.022, Method: Compositional matrix adjust.
Identities = 53/205 (26%), Positives = 85/205 (41%), Gaps = 15/205 (7%)
Query 1633 WKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALIL 1692
+K + G +K DNNC++++ LQ + FN EA+ + + GD +F L
Sbjct 1075 FKTTNLNGKIILKQGDNNCWINACCYQLQAFDF-FN----NEAWEKFKKGDVMDFVNLCY 1129
Query 1693 AYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLS 1752
A + G GD + +L + +AK VL C CG+K L E ++ T
Sbjct 1130 AATTLARGHSGDAEYLLELMLN--DYSTAKIVLAAKCG-CGEKEIVL---ERAVFKLTPL 1183
Query 1753 YDNLKTGVSIPCVCGRDATQYLVQQESSFV--MMSAPPAEYKLQQGTFLCANEYTGNYQC 1810
++ GV C+ V+ FV ++S E + A YTG Q
Sbjct 1184 KESFNYGVCGDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVKPVMHA-VYTGTTQN 1242
Query 1811 GHYTHITAKETLYRIDGAHLTKMSE 1835
GHY + E Y +DG + + +
Sbjct 1243 GHYM-VDDIEHGYCVDGMGIKPLKK 1266
>sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmissible
gastroenteritis coronavirus (strain Purdue) OX=11151
GN=rep PE=1 SV=1
Length=6684
Score = 1111 bits (2873), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 720/2176 (33%), Positives = 1108/2176 (51%), Gaps = 155/2176 (7%)
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILG 2299
CNG + Y NSS + + C S C CL+ D L + + +QVT +K D
Sbjct 1921 CNGAVQAYKNSSFIKSA-VCGNSILCKACLASYDELADF---QHLQVTWD-FKSDPLWNR 1975
Query 2300 LAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWF-------IISIVQMA 2352
L L+Y F F + ++ F YF S ++ N WL +F + +V
Sbjct 1976 LVQ---LSYFAFLAVFG----NNYVRCFLMYFVSQYL-NLWLSYFGYVEYSWFLHVVNFE 2027
Query 2353 PVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFY 2412
+SA + + K HI+ C++ +C C + R TR+ +VNG ++ Y
Sbjct 2028 SISAEFVIVVIVVKAVLALK---HIVFACSNPSCKTCSRTARQTRIPIQVVVNGSMKTVY 2084
Query 2413 VYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVA 2472
V+ANG FCK HN+ C NCD++ +TFI DE+ RDLS K+ + TD+S V V
Sbjct 2085 VHANGTGKFCKKHNFYCKNCDSYGFENTFICDEIVRDLSNSVKQTVYATDRSHQEVTKVE 2144
Query 2473 VKNGALHLY---------FDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+G Y +D +K + L + LD+ + GS NV
Sbjct 2145 CSDGFYRFYVGDEFTSYDYDVKHKKYSSQEVLKSMLLLDDFIVYSPSGSALANV------ 2198
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
++A VY+SQL+ +PI +++ L+ D+ S + +F+A + +F+V +
Sbjct 2199 --------RNACVYFSQLIGKPIKIVNSDLLEDL--SVDFKGALFNAKKNVIKNSFNVDV 2248
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVT 2643
+ K L E + L+ STF A +H + +T
Sbjct 2249 SECKNL-----DECYRACNLNVSFSTFEMAVNN------------------AHRFGILIT 2285
Query 2644 GDSCNNFMLTYNK--VENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQ 2701
S NNF + K ++ D+G C+ +A+ +NA+V S++W +D+ +LS
Sbjct 2286 DRSFNNFWPSKVKPGSSGVSAMDIGKCMTSDAKIVNAKVLTQRGKSVVWLSQDFAALSST 2345
Query 2702 LRKQIRSAAKKNNIPFRLTCATTRQVVNV----ITTKISLKGGKIVSTCFKLMLKATLLC 2757
+K + + + F LT ++ T +S K G + + +L
Sbjct 2346 AQKVLVKTFVEEGVNFSLTFNAVGSDDDLPYERFTESVSPKSGSGFFDVITQLKQIVILV 2405
Query 2758 VLAALVC-----YIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFD 2812
+ +C Y V + +GY Y I++G+ + T C N + GF
Sbjct 2406 FVFIFICGLCSVYSVATQSYIESAEGYD-----YMVIKNGIVQPFDDTISCVHNTYKGFG 2460
Query 2813 AWFSQRGGSYKN-DKSCP-VVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVG 2870
WF + G KSCP VV + E +P +P V +I G L F V
Sbjct 2461 DWFKAKYGFIPTFGKSCPIVVGTVFDLENMRPIPDVPAYV--SIVGRSLVFAINAAFGVT 2518
Query 2871 NICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTR 2930
N+CY + D CV CT +G + YC L+EG+ YS+L PD
Sbjct 2519 NMCYDHTGNAVSKDSYFDTCVFNTACTTLT-GLGGTIVYCAKQGLVEGAKLYSDLMPDYY 2577
Query 2931 YVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRA 2990
Y G++++ P +R V T YCR G C S+ G C +V +NE
Sbjct 2578 YEHASGNMVKLPAIIRGLGLRFVKTQATTYCRVGECIDSKAGFCFGGDNWFVYDNEFG-- 2635
Query 2991 LSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGE 3050
+G CG + N+F + + S +++ IIA L Y +KF+++FG+
Sbjct 2636 -NGYICGNSVLGFFKNVFKLFNSNMSVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGD 2694
Query 3051 YNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAM 3108
++ ++ L+ + V +F +Y++ Y ++ T +++ L +
Sbjct 2695 CTFLIVM-IIVTLVVNNVSYFVTQNTFFMIIYAIVY----YFITRKLAYPGILDAGFIIA 2749
Query 3109 FSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMY 3167
+ + P+++ Y+ F + +F G F FE AA+ TF+++ Y
Sbjct 2750 YINMAPWYVITAYILVFLYDSLPSLFKLKVSTN-LFEGDKFVGNFESAAMGTFVIDMRSY 2808
Query 3168 LKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLY 3227
+ + T + + Y +NKYKY++G++ YR A HL KAL D+S + D+LY
Sbjct 2809 ETIVNST--SIARIKSYANSFNKYKYYTGSMGEADYRMACYAHLGKALMDYSVNRTDMLY 2866
Query 3228 QPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAE 3287
PP S+ S LQSG RKMA PSG VE C+V+V+ G LNGLWL D V CPRHVI +
Sbjct 2867 TPPTVSVNST-LQSGLRKMAQPSGLVEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDT 2925
Query 3288 DMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQ 3347
+ NYE+ + H+F V NV L V+ + L LKV+ NP TP++KF I+
Sbjct 2926 TRV-INYENEMSSVRLHNFSVSKNNVFLGVVSARYKGVNLVLKVNQVNPNTPEHKFKSIK 2984
Query 3348 PGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMEL 3407
G++F++LACY G P VY MR TIKGSF+ G+CGSVG+ ++ + F YMHH+EL
Sbjct 2985 AGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLEL 3044
Query 3408 PTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTL 3467
G H G++ EG+ YG + D+ + Q GT+ + NV+A+LYAA+ING+RWF+ + +L
Sbjct 3045 GNGSHVGSNFEGEMYGGYEDQPSMQLEGTNVMSSDNVVAFLYAALINGERWFVTNTSMSL 3104
Query 3468 NDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTIL 3527
+N A ++ L+ D L+A+TG +V + ++ L G GRTIL L
Sbjct 3105 ESYNTWAKTNSFTELSS--TDAFSMLAAKTGQSVEKLLDSIVRL-NKGFGGRTILSYGSL 3161
Query 3528 EDEFTPFDVVRQCSGVTFQ-GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFF----F 3582
DEFTP +V+RQ GV Q GK K + + ++T +T L W FF F
Sbjct 3162 CDEFTPTEVIRQMYGVNLQAGKVK-----SFFYPIMTAMTILFAF-----WLEFFMYTPF 3211
Query 3583 VYEN-AFLPFTLGIMAIAACAMLL-VKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRI 3640
+ N F+ L + + + + +KHK F F+LPS+ V N+ + S+ +
Sbjct 3212 TWINPTFVSIVLAVTTLISTVFVSGIKHKMLFFMSFVLPSVILVTAHNL-FWDFSYYESL 3270
Query 3641 MTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY---K 3697
+ +E +T ++ ++ ++ + + R ++ W + V T++
Sbjct 3271 QSIVENTNTMFLPVDMQGVMLTVFCFIVFVTYSVRFF---TCKQSWFSLAVTTILVIFNM 3327
Query 3698 VYYGNALDQA----------ISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLF 3747
V D+ ++M +++S+T+ VV +A IV VCV P F
Sbjct 3328 VKIFGTSDEPWTENQIAFCFVNMLTMIVSLTTKDWMVVIASYRIAYYIV-VCV--MPSAF 3384
Query 3748 ITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLL 3806
++ ++CI +VY GY CCY+G+ +NR+ +T GVY + VS E +YM + L
Sbjct 3385 VSDFGFMKCISIVYMACGYLFCCYYGILYWVNRFTCMTCGVYQFTVSAAELKYMTANNLS 3444
Query 3807 PPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWA 3866
PK++ DA L+ KL+G+GGK IK++TVQSK++++KCT+VVLL +L ++ VES+SK W
Sbjct 3445 APKNAYDAMILSAKLIGVGGKRNIKISTVQSKLTEMKCTNVVLLGLLSKMHVESNSKEWN 3504
Query 3867 QCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFS 3926
CV LHN+I L D EK+++L++ LS D++ L E +N LQ++AS ++
Sbjct 3505 YCVGLHNEINLCDDPEIVLEKLLALIAFFLSKHNTCDLSELIESYFENTTILQSVASAYA 3564
Query 3927 SLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAM 3986
+LPS+ A A+ E+A N S +LK+L K+ N+AKS+F+R+A++Q+KL+KMA+QA
Sbjct 3565 ALPSWIALEKARADLEEAKKNDVSPQILKQLTKAFNIAKSDFEREASVQKKLDKMAEQAA 3624
Query 3987 TQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAK 4046
MYK+AR+ D+++K+ SAM ++LF ML+KLD ++N II+ AR+G +PL+IIP +A +
Sbjct 3625 ASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDMSSVNTIIDQARNGVLPLSIIPAASATR 3684
Query 4047 LMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVT 4106
L+V+ P + N YA A+W I +V DA+ V L E+ N NL WPL +T
Sbjct 3685 LVVITPSLEVFSKIRQENNVHYAGAIWTIVEVKDANGSHVHLKEVTAANELNLTWPLSIT 3744
Query 4107 ALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQ 4166
R KLQNNE+ P L++ + A T + A + G F+ A ++
Sbjct 3745 CER---TTKLQNNEIMPGKLKERAVRASATLDGEAFGSGKALMASESGKSFMYAFIASDN 3801
Query 4167 DLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAAT 4226
+LK+ ++ ++ I ELE P RF D GP+VKYLYF+K LN L RG VLG + AT
Sbjct 3802 NLKYVKWESNN--DIIPIELEAPLRFYVDGANGPEVKYLYFVKNLNTLRRGAVLGYIGAT 3859
Query 4227 VRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAIT 4286
VRLQAG TE P+NS++L+ CAF+ DPAKAY D + G QP+ NCVKML G G A+T
Sbjct 3860 VRLQAGKPTEHPSNSSLLTLCAFSPDPAKAYVDAVKRGMQPVNNCVKMLSNGAGNGMAVT 3919
Query 4287 VTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTV 4346
EAN Q+S+GGAS C+YCRCH++HP G C KGK+VQIPT DP+ F + N V
Sbjct 3920 NGVEANTQQDSYGGASVCIYCRCHVEHPAIDGLCRYKGKFVQIPTG-TQDPIRFCIENEV 3978
Query 4347 CTVCGMWKGYGCSCDQ 4362
C VCG W GC CD+
Sbjct 3979 CVVCGCWLNNGCMCDR 3994
Score = 65.9 bits (159), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 73/274 (27%), Positives = 119/274 (43%), Gaps = 24/274 (9%)
Query 969 ETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQ 1028
+ +VE+ E++ +++ E E P ++ + F KL+ +D++
Sbjct 1288 QEFKVEKVEQQPIVEENKSSIEKEEIQSPKNDDLILPFYKAGKLS--FYQGALDVL--IN 1343
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
P VIVNAAN LKH GGVA A++ T G + + S DY+K N + G +
Sbjct 1344 FLEPDVIVNAANGDLKHMGGVARAIDVFTGGKLTERSKDYLKKNKSIAPGNAVFFENVIE 1403
Query 1089 AKKCLHVVGP-NLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTV 1147
L+ VGP N ++ + +L + +L PL+S GIF + SLQ ++T
Sbjct 1404 HLSVLNAVGPRNGDSRVEAKLCNVYKAIAKCEGKILTPLISVGIFNVRLETSLQCLLKT- 1462
Query 1148 RTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP--NTEDSKTEEKSVVQKPVDVK 1205
VND+ L V Y D + +E P TED+ E+ V
Sbjct 1463 -------VNDRGLN---VFVYTDQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKTYG 1512
Query 1206 PKIKACIDEVTTTLEETKFLTNKLLLFADINGKL 1239
++K T + + K +TN+L D+ K+
Sbjct 1513 EQLKG------TVVIKDKDVTNQLPSAFDVGQKV 1540
Score = 47.0 bits (110), Expect = 0.007, Method: Compositional matrix adjust.
Identities = 71/287 (25%), Positives = 115/287 (40%), Gaps = 31/287 (11%)
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
+I V T DN N V TYG+Q G + DVT P G+ V+ + D
Sbjct 1488 SIPVNVTEDNVNHERVSVSFDKTYGEQLKGTVVIKDKDVTNQLPSAFDVGQK--VIKAID 1545
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSI--KWADNNCYLSSVLLAL 1660
+ +Y D + SA +H +KF V I K DNNC+++++ LAL
Sbjct 1546 I---DWQAHYGFRDAAAF----SASSH-DAYKFEVVTHSNFIVHKQTDNNCWINAICLAL 1597
Query 1661 QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES 1720
Q+L+ ++ P ++ + F ++ S GE GD E M H L
Sbjct 1598 QRLKPQWKFPGVRGLWNEFLERKTQGFVHMLYHISGVKKGEPGDA-ELMLHKLGDLMDND 1656
Query 1721 AKRVL--NVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKT-GVSIPCVCGRDATQYLVQQ 1777
+ ++ C C + VE ++G + L G CV G + Q
Sbjct 1657 CEIIVTHTTACDKCAK-------VEK--FVGPVVAAPLAIHGTDETCVHGVSVNVKVTQI 1707
Query 1778 ESSFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETL 1822
+ + + S P L+ ++C Y+G+ + GHYT+ + L
Sbjct 1708 KGTVAITSLIGPIIGEVLEATGYIC---YSGSNRNGHYTYYDNRNGL 1751
Score = 45.1 bits (105), Expect = 0.022, Method: Compositional matrix adjust.
Identities = 53/205 (26%), Positives = 85/205 (41%), Gaps = 15/205 (7%)
Query 1633 WKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALIL 1692
+K + G +K DNNC++++ LQ + FN EA+ + + GD +F L
Sbjct 1075 FKTTNLNGKIILKQGDNNCWINACCYQLQAFDF-FN----NEAWEKFKKGDVMDFVNLCY 1129
Query 1693 AYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLS 1752
A + G GD + +L + +AK VL C CG+K L E ++ T
Sbjct 1130 AATTLARGHSGDAEYLLELMLN--DYSTAKIVLAAKCG-CGEKEIVL---ERAVFKLTPL 1183
Query 1753 YDNLKTGVSIPCVCGRDATQYLVQQESSFV--MMSAPPAEYKLQQGTFLCANEYTGNYQC 1810
++ GV C+ V+ FV ++S E + A YTG Q
Sbjct 1184 KESFNYGVCGDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVKPVMHA-VYTGTTQN 1242
Query 1811 GHYTHITAKETLYRIDGAHLTKMSE 1835
GHY + E Y +DG + + +
Sbjct 1243 GHYM-VDDIEHGYCVDGMGIKPLKK 1266
Score = 37.0 bits (84), Expect = 5.7, Method: Compositional matrix adjust.
Identities = 52/256 (20%), Positives = 100/256 (39%), Gaps = 21/256 (8%)
Query 604 GLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV--K 661
GL+ + + W G + E + L+ K +E++ L T F IV K
Sbjct 380 GLLFKKTPWFVQKCGALFVDAWKVVEELCGSLTLT---YKQIYEVVASLCTSAFTIVNYK 436
Query 662 GQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC- 720
V + +KD V + V+ KA ++ +TIAG + + LG ++ + L +
Sbjct 437 PTFVVPDNRVKDLVDKCVKVLVKAFDVFTQIITIAGIEAKCFVLGAKYLLFNNALVKLVS 496
Query 721 --IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAI 778
I GK+Q L A + + + T +E + +++ + P + +
Sbjct 497 VKILGKKQKGLECAFFA---TSLVGATVNVTPKRTETATISLNKVDDVVAPGEGY----- 548
Query 779 VGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYK 838
+ + G M + + SP + TNNVF+ P + + D + +
Sbjct 549 ----IVIVGDMAFYKSGEYYFMMSSPNFVLTNNVFKAV-KVPSYDIVYDVDNDTKSKMIA 603
Query 839 NVRITFELDERVDKVL 854
+ +FE D +D +
Sbjct 604 KLGSSFEYDGDIDAAI 619
>sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain Beaudette CK) OX=160235 GN=1a PE=3
SV=1
Length=3951
Score = 1100 bits (2845), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 754/2263 (33%), Positives = 1132/2263 (50%), Gaps = 217/2263 (10%)
Query 2238 SYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTI 2297
S C ++ +S +V + +C F C +CL DSL Y +++ YK +
Sbjct 1783 SLCGPYKDYGKDSFDV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS- 1836
Query 2298 LGLAAEWVLAYMLFTKFFY--LLGLSAIMQVFFGYFASHFISNS--------WLMWFIIS 2347
G W Y++F F + G V Y + + NS +L WF
Sbjct 1837 -GFIFNWNWLYLVFLILFVKPVAGF-----VIICYCVKYLVLNSTVLQTGVCFLDWF--- 1887
Query 2348 IVQMAPVSAMVRMYIFFASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTT 2402
V + + F + +Y W Y VH + C TC +C + R+ R E +
Sbjct 1888 ------VQTVFSHFNFMGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSV 1941
Query 2403 IVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTD 2462
+V G K+ +VY N G FCK HNW C NCD + +TF+S EVA +LS + KR + PT
Sbjct 1942 VVGGRKQIVHVYTNSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTA 2001
Query 2463 QSSYIVDSVAVKNGALHLYFDKAGQ-KTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVF 2520
+ ++VD + + ++L + A K + F D L+ A K +L I
Sbjct 2002 YAYHVVDEACLVDDFVNLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISN 2061
Query 2521 DGKSKCDESAS------KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDT 2574
DG C+ ++ K+A++YY+Q +C+PIL+LDQAL + VS + D
Sbjct 2062 DGFIVCNTQSAHALEEAKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSI 2120
Query 2575 FSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECL 2632
S+ SV TA G D +LS TKD ++
Sbjct 2121 LSSIISVD---------TAALNYKAGTLRDALLSI---------------TKDEEAVDMA 2156
Query 2633 KLSHHSDLEVTGDSCNNFMLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWN 2691
H+ D++ TGD N + +Y +TPRD G I+ +A N +V + V +W
Sbjct 2157 IFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPV--VWK 2214
Query 2692 VKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TC 2746
+ + LS+ K + SA K+ + F +T + +QV+ T K+ + K G IVS C
Sbjct 2215 FSELIKLSDSCLKYLISATVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKC 2274
Query 2747 FKLMLKATLLCVLAALVC---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIIS 2799
FK K L+ + C Y M V +H Y T + G+K I GV R+I+
Sbjct 2275 FKSYFKWLLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVP 2334
Query 2800 TDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DF 2858
D CF+NK FDA++ G Y N ++CP+V A+I + G + G+PG V ++G F
Sbjct 2335 EDTCFSNKFVNFDAFW---GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMF 2390
Query 2859 LH---------FLPRVFS--AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPV 2907
+H ++P F+ VG YT +I F TS + +A C ++ A P
Sbjct 2391 IHMTQTERKPWYIPTWFNREIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQ 2446
Query 2908 PYCYD-TNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTC 2966
YC++ N G++ + + P Y +G + P L + VV YCR C
Sbjct 2447 LYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVC 2505
Query 2967 ERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVA 3026
E + G C+S + +WVL N+ Y + GVFCG L+ ++ + V ++ +
Sbjct 2506 EYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLAT 2564
Query 3027 GGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFY 3086
+I ++V +KF+ VF Y V L+++++ ILC+ S L + V Y
Sbjct 2565 MFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLY 2624
Query 3087 LYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH---WFFNNYLRKRVM 3143
Y + + + + H F IVP W+ Y+ I + W + R +
Sbjct 2625 CYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKL 2684
Query 3144 FNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
++G F ++ AA TF++ ++KL +E ++ YL+ Y + KY+SG
Sbjct 2685 YDGNEFVGNYDLAAKSTFVIRGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQD 2741
Query 3203 YREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTC 3262
Y +A LA AL+ + NSG +++Y PP+ SI + LQSGF+K+ PS VE C+V V+
Sbjct 2742 YLQACRAWLAYALDQYRNSGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSY 2801
Query 3263 GTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHS 3321
LNGLWL DT+YCPRHV+ + D+L +NH F V + V L V+
Sbjct 2802 RGNNLNGLWLGDTIYCPRHVL---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRR 2858
Query 3322 MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFL 3381
++ +L L+ +N +TPKYKF++ G +F++ Y G+ G+Y MR N TI+ SFL
Sbjct 2859 LKGAVLILQTAVANAETPKYKFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFL 2918
Query 3382 NGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTIT 3441
G+CGSVGFNI+ V+F YMHH+ELP +H GTDL G+FYG +VD + AQ D +T
Sbjct 2919 AGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVT 2978
Query 3442 LNVLAWLYAAVINGD-------RWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLS 3494
N++AWLYAA+I+ +W L T +++D+N A + P + + LS
Sbjct 2979 NNIVAWLYAAIISVKESSFSLPKW-LESTTVSVDDYNKWAGDNGFTPFSTSTA--ITKLS 3035
Query 3495 AQTGIAVLDMCAALKELL--QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKI 3552
A TG+ D+C L+ ++ + G ILG EDE TP V Q GV Q F
Sbjct 3036 AITGV---DVCKLLRTIMVKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF--- 3089
Query 3553 VKGTHHW-----MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVK 3607
V+ W +L FL L +V T L F+VY L +MA+ + VK
Sbjct 3090 VRKATSWFWSRCVLACFLFVLCAIVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVK 3143
Query 3608 HKHAFLCLFLLPSLAT--------------------VAYFNMVYMPASWVMRIMTWLELA 3647
H A++ FLLP+L T V + + Y P + ++ W+ L
Sbjct 3144 HVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLP 3202
Query 3648 DTSLSGYR-LKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQ 3706
+ ++ ++ C M + LL+L + ++T N +T + GN
Sbjct 3203 LVLYTAFKCVQGCYMNSFNTSLLMLYQ----FVKLGFVIYTSSNTLTAYTE---GN---- 3251
Query 3707 AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFL 3763
W L + + L VF C + YY N + ++V C +
Sbjct 3252 ----WELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-I 3306
Query 3764 GYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLG 3823
G+ C CYFGL+ +N+ F LTLG Y++ VS ++RYM + PPK+ + F NI + G
Sbjct 3307 GWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQG 3366
Query 3824 IGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE 3883
IGG + +ATVQ+K+SDVKCT+VVL+ +L +L VE++SK+ V+LHN IL + D E
Sbjct 3367 IGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGE 3426
Query 3884 AFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQ 3943
+ ++ +L L + +D++ C+++L LQ++ EFS +PSYA Y A+ YE+
Sbjct 3427 CMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEK 3486
Query 3944 AVAN----GDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKR 3999
+ + G ++ L +K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+R
Sbjct 3487 VLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRR 3546
Query 4000 AKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKN 4059
AK+ S++ +LF+ML+K+D++ LN + + A G VPL +P+ + KL +V+PD T+
Sbjct 3547 AKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVK 3606
Query 4060 TCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA- 4113
+G TY++ +W I V+DAD + + + N+AWPL V R
Sbjct 3607 CVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNK 3666
Query 4114 --VKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWA 4171
V LQNNEL P ++ +C AG Q C+ ++ YY N G V A+ S + +LK A
Sbjct 3667 VDVVLQNNELMPHGVKTKACVAGVDQAHCSVESK-CYYTNISGNSVVAAITSSNPNLKVA 3725
Query 4172 RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA 4231
F G IY +L+PPC+F +V YLYFIK ++ RGMVLG+++ V LQ+
Sbjct 3726 SFLNEAGN-QIYVDLDPPCKFGMKVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQS 3784
Query 4232 -GNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
G+ TE +LS C+FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P
Sbjct 3785 KGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPS 3844
Query 4291 ANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTV 4346
DQ+S+GGAS CLYCR HI HP N G C KG +VQIPTT DPVGF LRN V
Sbjct 3845 PTPDQDSYGGASVCLYCRAHIAHPGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKV 3903
Query 4347 CTVCGMWKGYGCSCDQLREP---LMQSADASTF----LNGFAV 4382
CTVC W GYGC CD LR+P + A AS F LNG+ V
Sbjct 3904 CTVCQCWIGYGCQCDSLRQPKSSVQSVAGASDFDKNYLNGYGV 3946
Score = 65.5 bits (158), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/220 (26%), Positives = 95/220 (43%), Gaps = 14/220 (6%)
Query 1570 QFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNH 1629
QFG Y V + E K +P+ D EYY LD Y+ L
Sbjct 1202 QFGQVYAKNKIVFTAD---DVEDKEILYVPTTD---KSILEYY-GLDAQKYVIYLQTL-- 1252
Query 1630 TKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCA 1689
+KW ++W D NC++SS ++ LQ +++F L EA+ + GD +F A
Sbjct 1253 AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKG-FLTEAWAKLLGGDPTDFVA 1311
Query 1690 LILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN--VVCKHCGQKTTTLTGVEA-VM 1746
A VG+ D + +L +H + + L V C +CG K+ L G+EA +
Sbjct 1312 WCYASCTAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSC-NCGIKSYELRGLEACIQ 1370
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
+ + + KT S CG + T +++ ++++ A
Sbjct 1371 PVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFA 1410
Score = 50.1 bits (118), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 51/186 (27%), Positives = 82/186 (44%), Gaps = 15/186 (8%)
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
V I K IVNAAN H+ HG GVA A+ + +DY+K +GP
Sbjct 1025 VVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---R 1081
Query 1081 CLLSGHNLAKKCL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPL 1137
+ +C+ +VVGP + L AAY+N ++ + P+LS GIFG
Sbjct 1082 LVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGV--- 1138
Query 1138 QSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSV 1197
++ + +R + + + L + +++D KQ+ TED + +S+
Sbjct 1139 -DFKMSIDAMR-EAFEGCTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSI 1192
Query 1198 VQKPVD 1203
V KP D
Sbjct 1193 VLKPGD 1198
>sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain Beaudette) OX=11122 GN=1a PE=1 SV=1
Length=3951
Score = 1100 bits (2845), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 754/2263 (33%), Positives = 1132/2263 (50%), Gaps = 217/2263 (10%)
Query 2238 SYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTI 2297
S C ++ +S +V + +C F C +CL DSL Y +++ YK +
Sbjct 1783 SLCGPYKDYGKDSFDV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS- 1836
Query 2298 LGLAAEWVLAYMLFTKFFY--LLGLSAIMQVFFGYFASHFISNS--------WLMWFIIS 2347
G W Y++F F + G V Y + + NS +L WF
Sbjct 1837 -GFIFNWNWLYLVFLILFVKPVAGF-----VIICYCVKYLVLNSTVLQTGVCFLDWF--- 1887
Query 2348 IVQMAPVSAMVRMYIFFASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTT 2402
V + + F + +Y W Y VH + C TC +C + R+ R E +
Sbjct 1888 ------VQTVFSHFNFMGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSV 1941
Query 2403 IVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTD 2462
+V G K+ +VY N G FCK HNW C NCD + +TF+S EVA +LS + KR + PT
Sbjct 1942 VVGGRKQIVHVYTNSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTA 2001
Query 2463 QSSYIVDSVAVKNGALHLYFDKAGQ-KTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVF 2520
+ ++VD + + ++L + A K + F D L+ A K +L I
Sbjct 2002 YAYHVVDEACLVDDFVNLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISN 2061
Query 2521 DGKSKCDESAS------KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDT 2574
DG C+ ++ K+A++YY+Q +C+PIL+LDQAL + VS + D
Sbjct 2062 DGFIVCNTQSAHALEEAKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSI 2120
Query 2575 FSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECL 2632
S+ SV TA G D +LS TKD ++
Sbjct 2121 LSSIISVD---------TAALNYKAGTLRDALLSI---------------TKDEEAVDMA 2156
Query 2633 KLSHHSDLEVTGDSCNNFMLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWN 2691
H+ D++ TGD N + +Y +TPRD G I+ +A N +V + V +W
Sbjct 2157 IFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPV--VWK 2214
Query 2692 VKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TC 2746
+ + LS+ K + SA K+ + F +T + +QV+ T K+ + K G IVS C
Sbjct 2215 FSELIKLSDSCLKYLISATVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKC 2274
Query 2747 FKLMLKATLLCVLAALVC---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIIS 2799
FK K L+ + C Y M V +H Y T + G+K I GV R+I+
Sbjct 2275 FKSYFKWLLIFYILFTACCSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVP 2334
Query 2800 TDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DF 2858
D CF+NK FDA++ G Y N ++CP+V A+I + G + G+PG V ++G F
Sbjct 2335 EDTCFSNKFVNFDAFW---GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMF 2390
Query 2859 LH---------FLPRVFS--AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPV 2907
+H ++P F+ VG YT +I F TS + +A C ++ A P
Sbjct 2391 IHMTQTERKPWYIPTWFNREIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQ 2446
Query 2908 PYCYD-TNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTC 2966
YC++ N G++ + + P Y +G + P L + VV YCR C
Sbjct 2447 LYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVC 2505
Query 2967 ERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVA 3026
E + G C+S + +WVL N+ Y + GVFCG L+ ++ + V ++ +
Sbjct 2506 EYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLAT 2564
Query 3027 GGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFY 3086
+I ++V +KF+ VF Y V L+++++ ILC+ S L + V Y
Sbjct 2565 MFLILVVVVLIFAMVIKFQGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLY 2624
Query 3087 LYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH---WFFNNYLRKRVM 3143
Y + + + + H F IVP W+ Y+ I + W + R +
Sbjct 2625 CYASLVTSRNTVIIMHCWLVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKL 2684
Query 3144 FNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
++G F ++ AA TF++ ++KL +E ++ YL+ Y + KY+SG
Sbjct 2685 YDGNEFVGNYDLAAKSTFVIRGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQD 2741
Query 3203 YREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTC 3262
Y +A LA AL+ + NSG +++Y PP+ SI + LQSGF+K+ PS VE C+V V+
Sbjct 2742 YLQACRAWLAYALDQYRNSGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSY 2801
Query 3263 GTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHS 3321
LNGLWL DT+YCPRHV+ + D+L +NH F V + V L V+
Sbjct 2802 RGNNLNGLWLGDTIYCPRHVL---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRR 2858
Query 3322 MQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFL 3381
++ +L L+ +N +TPKYKF++ G +F++ Y G+ G+Y MR N TI+ SFL
Sbjct 2859 LKGAVLILQTAVANAETPKYKFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFL 2918
Query 3382 NGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTIT 3441
G+CGSVGFNI+ V+F YMHH+ELP +H GTDL G+FYG +VD + AQ D +T
Sbjct 2919 AGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVT 2978
Query 3442 LNVLAWLYAAVINGD-------RWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLS 3494
N++AWLYAA+I+ +W L T +++D+N A + P + + LS
Sbjct 2979 NNIVAWLYAAIISVKESSFSLPKW-LESTTVSVDDYNKWAGDNGFTPFSTSTA--ITKLS 3035
Query 3495 AQTGIAVLDMCAALKELL--QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKI 3552
A TG+ D+C L+ ++ + G ILG EDE TP V Q GV Q F
Sbjct 3036 AITGV---DVCKLLRTIMVKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF--- 3089
Query 3553 VKGTHHW-----MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVK 3607
V+ W +L FL L +V T L F+VY L +MA+ + VK
Sbjct 3090 VRKATSWFWSRCVLACFLFVLCAIVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVK 3143
Query 3608 HKHAFLCLFLLPSLAT--------------------VAYFNMVYMPASWVMRIMTWLELA 3647
H A++ FLLP+L T V + + Y P + ++ W+ L
Sbjct 3144 HVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLP 3202
Query 3648 DTSLSGYR-LKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQ 3706
+ ++ ++ C M + LL+L + ++T N +T + GN
Sbjct 3203 LVLYTAFKCVQGCYMNSFNTSLLMLYQ----FVKLGFVIYTSSNTLTAYTE---GN---- 3251
Query 3707 AISMWALVISVTSNYSGVVTTIMFLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFL 3763
W L + + L VF C + YY N + ++V C +
Sbjct 3252 ----WELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-I 3306
Query 3764 GYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLG 3823
G+ C CYFGL+ +N+ F LTLG Y++ VS ++RYM + PPK+ + F NI + G
Sbjct 3307 GWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQG 3366
Query 3824 IGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTE 3883
IGG + +ATVQ+K+SDVKCT+VVL+ +L +L VE++SK+ V+LHN IL + D E
Sbjct 3367 IGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGE 3426
Query 3884 AFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQ 3943
+ ++ +L L + +D++ C+++L LQ++ EFS +PSYA Y A+ YE+
Sbjct 3427 CMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEK 3486
Query 3944 AVAN----GDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKR 3999
+ + G ++ L +K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+R
Sbjct 3487 VLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRR 3546
Query 4000 AKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKN 4059
AK+ S++ +LF+ML+K+D++ LN + + A G VPL +P+ + KL +V+PD T+
Sbjct 3547 AKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVK 3606
Query 4060 TCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA- 4113
+G TY++ +W I V+DAD + + + N+AWPL V R
Sbjct 3607 CVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNK 3666
Query 4114 --VKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWA 4171
V LQNNEL P ++ +C AG Q C+ ++ YY N G V A+ S + +LK A
Sbjct 3667 VDVVLQNNELMPHGVKTKACVAGVDQAHCSVESK-CYYTNISGNSVVAAITSSNPNLKVA 3725
Query 4172 RFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA 4231
F G IY +L+PPC+F +V YLYFIK ++ RGMVLG+++ V LQ+
Sbjct 3726 SFLNEAGN-QIYVDLDPPCKFGMKVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQS 3784
Query 4232 -GNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
G+ TE +LS C+FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P
Sbjct 3785 KGHETEEVDAVGILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPS 3844
Query 4291 ANMDQESFGGASCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTV 4346
DQ+S+GGAS CLYCR HI HP N G C KG +VQIPTT DPVGF LRN V
Sbjct 3845 PTPDQDSYGGASVCLYCRAHIAHPGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKV 3903
Query 4347 CTVCGMWKGYGCSCDQLREP---LMQSADASTF----LNGFAV 4382
CTVC W GYGC CD LR+P + A AS F LNG+ V
Sbjct 3904 CTVCQCWIGYGCQCDSLRQPKSSVQSVAGASDFDKNYLNGYGV 3946
Score = 65.5 bits (158), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/220 (26%), Positives = 95/220 (43%), Gaps = 14/220 (6%)
Query 1570 QFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNH 1629
QFG Y V + E K +P+ D EYY LD Y+ L
Sbjct 1202 QFGQVYAKNKIVFTAD---DVEDKEILYVPTTD---KSILEYY-GLDAQKYVIYLQTL-- 1252
Query 1630 TKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCA 1689
+KW ++W D NC++SS ++ LQ +++F L EA+ + GD +F A
Sbjct 1253 AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKG-FLTEAWAKLLGGDPTDFVA 1311
Query 1690 LILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN--VVCKHCGQKTTTLTGVEA-VM 1746
A VG+ D + +L +H + + L V C +CG K+ L G+EA +
Sbjct 1312 WCYASCTAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSC-NCGIKSYELRGLEACIQ 1370
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
+ + + KT S CG + T +++ ++++ A
Sbjct 1371 PVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFA 1410
Score = 50.1 bits (118), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 51/186 (27%), Positives = 82/186 (44%), Gaps = 15/186 (8%)
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
V I K IVNAAN H+ HG GVA A+ + +DY+K +GP
Sbjct 1025 VVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---R 1081
Query 1081 CLLSGHNLAKKCL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPL 1137
+ +C+ +VVGP + L AAY+N ++ + P+LS GIFG
Sbjct 1082 LVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGV--- 1138
Query 1138 QSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSV 1197
++ + +R + + + L + +++D KQ+ TED + +S+
Sbjct 1139 -DFKMSIDAMR-EAFEGCTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSI 1192
Query 1198 VQKPVD 1203
V KP D
Sbjct 1193 VLKPGD 1198
>sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain M41) OX=11127 GN=1a PE=1 SV=1
Length=3953
Score = 1097 bits (2836), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 748/2252 (33%), Positives = 1130/2252 (50%), Gaps = 229/2252 (10%)
Query 2256 MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFF 2315
+ +C G F C +CL DSL Y +++ YK + G+ W Y++F F
Sbjct 1801 LRYCAGDFTCRVCLHDRDSLHLYKHAYSVE---QIYKDAAS--GINFNWNWLYLVFLILF 1855
Query 2316 ---------------YLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRM 2360
YL+ S ++Q G+ L WF V +
Sbjct 1856 VKPVAGFVIICYCVKYLVLSSTVLQTGVGF----------LDWF---------VKTVFTH 1896
Query 2361 YIFFASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
+ F + +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY
Sbjct 1897 FNFMGAGFYFWLFYKIYVQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYT 1956
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
N G FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++V V +
Sbjct 1957 NSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVYEACVVD 2016
Query 2476 GALHLYFDKA-GQKTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVFDGKSKCDESAS-- 2531
++L + A K + F D L+ A K +L I DG C+ ++
Sbjct 2017 DFVNLKYKAAIPGKDNASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHA 2076
Query 2532 ----KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLK 2587
K+A+VYY+Q +C+PIL+LDQAL + VS + D S SV
Sbjct 2077 LEEAKNAAVYYAQYLCKPILILDQALYEQL-IVEPVSKSVIDKVCSILSNIISVD----- 2130
Query 2588 ALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECLKLSHHSDLEVTGD 2645
TA G D +LS TKD ++ H+ ++E TGD
Sbjct 2131 ----TAALNYKAGTLRDALLSI---------------TKDEEAVDMAIFCHNHEVEYTGD 2171
Query 2646 SCNNFMLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRK 2704
N + +Y + +TPRD G I+ +A N +V + V +W D + LS+ K
Sbjct 2172 GFTNVIPSYGMDTDKLTPRDRGFLINADASIANLRVKNAPPV--VWKFSDLIKLSDSCLK 2229
Query 2705 QIRSAAKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS-------TCFKLMLKATL 2755
+ SA K+ F +T + +QV++ T K+ + K G +++ +CFK + +
Sbjct 2230 YLISATVKSGGRFFITKSGAKQVISCHTQKLLVEKKAGGVINNTFKWFMSCFKWLFVFYI 2289
Query 2756 LCVLAALVCYIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGF 2811
L A + Y M ++ +H Y T + G+K I GV R+I+S D+CF+NK F
Sbjct 2290 L-FTACCLGYYYMEMNKSFVHPMYDVNSTLHVEGFKVIDKGVIREIVSEDNCFSNKFVNF 2348
Query 2812 DAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------F 2861
DA++ G SY+N+K+CP+V +I + G + G+PG V ++G F+H +
Sbjct 2349 DAFW---GKSYENNKNCPIVTVVIDGD-GTVAVGVPGFVSWVMDGVMFVHMTQTDRRPWY 2404
Query 2862 LPRVFS--AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEG 2918
+P F+ VG YT +I F TS + +A C ++ A P YC++ N G
Sbjct 2405 IPTWFNREIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPG 2460
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTS 2978
++ + + P Y +G + P L + +V YCR CE ++ G C+S
Sbjct 2461 ALPFGSIIPHRVYFQPNGVRLIVPQQILH-TPYIVKFVSDSYCRGSVCEYTKPGYCVSLD 2519
Query 2979 GRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAA 3038
+WVL N+ Y + GVFCG L+ N+ + V ++ + +I +++
Sbjct 2520 SQWVLFNDEYISKPGVFCGSTVRELMFNMVSTFFTGVNP-NIYIQLATMFLILVVIVLIF 2578
Query 3039 YYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVS 3098
+KF+ VF Y +V L+++++ +LC+ S L + V Y Y + + + +
Sbjct 2579 AMVIKFQGVFKAYATIVFTIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASMVTSRNTA 2638
Query 3099 FLAHLQWFAMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEE 3154
+ H F IVP W+ Y+ I + W + R +++G F ++
Sbjct 2639 IIMHCWLVFTFGLIVPTWLACCYLGFILYMYTPLVFWCYGTTKNTRKLYDGNEFVGNYDL 2698
Query 3155 AALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKA 3214
AA TF++ ++KL +E ++ YL+ Y + KY+SG Y +A LA A
Sbjct 2699 AAKSTFVIRGTEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYA 2755
Query 3215 LNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDD 3274
L+ + NSG +V+Y PP+ SI + LQ+GF+K+ PS VE C+V V+ LNGLWL D
Sbjct 2756 LDQYRNSGVEVVYTPPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGD 2815
Query 3275 TVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDT 3333
++YCPRHV+ + D+L +NH F V N V L V+ ++ +L L+
Sbjct 2816 SIYCPRHVL---GKFSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAV 2872
Query 3334 SNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNID 3393
+N +TPKYKFV+ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+
Sbjct 2873 ANAETPKYKFVKANCGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIE 2932
Query 3394 YDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVI 3453
V+F YMHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I
Sbjct 2933 KGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAII 2992
Query 3454 N-------GDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA 3506
+ +W L T ++ D+N A + P + + LSA TG+ D+C
Sbjct 2993 SVKESSFSQPKW-LESTTVSIEDYNRWASDNGFTPFSTSTA--ITKLSAITGV---DVCK 3046
Query 3507 ALKELLQNGMNGRT--ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW----- 3559
L+ ++ + ILG EDE TP V Q GV Q F V+ W
Sbjct 3047 LLRTIMVKSAQWGSDPILGQYNFEDELTPESVFNQVGGVRLQSSF---VRKATSWFWSRC 3103
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLP 3619
+L FL L +V T L F+V+ L +MA+ + VKH A++ FLLP
Sbjct 3104 VLACFLFVLCAIVLFTAVPLKFYVHAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLP 3157
Query 3620 SLATVA--------------------YFNMVYMPASWVMRIMTWLELADTSLSGYR-LKD 3658
+L TV + + Y P + ++ W+ L + ++ ++
Sbjct 3158 TLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMLLPLVLYTAFKCVQG 3216
Query 3659 CVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
C M + LL+L + ++T N +T + GN W L +
Sbjct 3217 CYMNSFNTSLLMLYQ----FMKLGFVIYTSSNTLTAYTE---GN--------WELFFELV 3261
Query 3719 SNYSGVVTTIMFLARAIVFVCVE----YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLF 3774
+ L IVF C + Y + L +M+ +G+ C CYFGL+
Sbjct 3262 HTIVLANVSSNSLIGLIVFKCAKWMLYYCNATYFNNYVLMAVMV--NGIGWLCTCYFGLY 3319
Query 3775 CLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVAT 3834
+N+ F LTLG Y++ VS ++RYM + PPK+ + F NI + GIGG + +AT
Sbjct 3320 WWVNKVFGLTLGKYNFKVSVDQYRYMCLHKVNPPKTVWEVFTTNILIQGIGGDRVLPIAT 3379
Query 3835 VQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSV 3894
VQSK+SDVKCT+VVL+ +L +L VE++SK+ A V+LHN IL + D E + ++ +L
Sbjct 3380 VQSKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVELHNKILASDDVGECMDNLLGMLIT 3439
Query 3895 LLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDS 3950
L + +D+ C+++L LQ++ EFS +PSYA Y A+ YE+ +A+ G +
Sbjct 3440 LFCIDSTIDLGEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKSIYEKVLADSKNGGVT 3499
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ L +K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +L
Sbjct 3500 QQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALL 3559
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+ML+K+D++ LN + + A G VPL +P+ + KL +V+PD T+ +G TY++
Sbjct 3560 FSMLKKIDSEKLNVLFDQANSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYST 3619
Query 4071 ALWEIQQVVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELS 4122
+W I V DAD + + + N+AWPL V R V LQNNEL
Sbjct 3620 VVWNIDCVTDADGTELHPTSTGSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELM 3679
Query 4123 PVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTI 4182
P ++ +C AG Q C+ ++ YY + G V A+ S + +LK A F G I
Sbjct 3680 PHGVKTKACVAGVDQAHCSVESK-CYYTSISGSSVVAAITSSNPNLKVASFLNEAGN-QI 3737
Query 4183 YTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANS 4241
Y +L+PPC+F +V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE
Sbjct 3738 YVDLDPPCKFGMKVGDKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAV 3797
Query 4242 TVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGA 4301
+LS C+FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGA
Sbjct 3798 GILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGA 3857
Query 4302 SCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYG 4357
S CLYCR HI HP N G C KG +VQIPTT DPVGF LRN VCTVC W GYG
Sbjct 3858 SVCLYCRAHIAHPGGAGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYG 3916
Query 4358 CSCDQLREP---LMQSADASTF----LNGFAV 4382
C CD LR+P + A AS F LNG+ V
Sbjct 3917 CQCDSLRQPKPSVQSVAVASGFDKNYLNGYGV 3948
Score = 69.7 bits (169), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 51/198 (26%), Positives = 90/198 (45%), Gaps = 9/198 (5%)
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
E K +P+ D E Y+ LD Y+ L +KW ++W D N
Sbjct 1222 EDKEILFIPTTDKTILE----YYGLDAQKYVTYLQTL--AQKWDVQYRDNFVILEWRDGN 1275
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
C++SS ++ LQ +++F L EA+ + GD +F A A N VG+ D +
Sbjct 1276 CWISSAIVLLQAAKIRFKG-FLAEAWAKLLGGDPTDFVAWCYASCNAKVGDFSDANWLLA 1334
Query 1711 HLLQHANLESAKRVL-NVVCKHCGQKTTTLTGVEA-VMYMGTLSYDNLKTGVSIPCVCGR 1768
+L +H + + +L V +CG K+ L G+EA + + + + KT S CG
Sbjct 1335 NLAEHFDADYTNALLKKCVSCNCGVKSYELRGLEACIQPVRAPNLLHFKTQYSNCPTCGA 1394
Query 1769 DATQYLVQQESSFVMMSA 1786
+T +++ ++++ A
Sbjct 1395 SSTDEVIEASLPYLLLFA 1412
Score = 56.2 bits (134), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 88/355 (25%), Positives = 140/355 (39%), Gaps = 53/355 (15%)
Query 878 EAVVKTL-QPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
E VK L Q V D+L + G +D A L S + F + + A
Sbjct 870 EGAVKALPQKVIDVLGDWGEAVD----AQEQLCQQESTRVISEKSVEGFTGSCDAMAEQA 925
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEE-------EEEDWLDDTTEQS 989
EE+EI E ++D P + ET +E +E+ + E+
Sbjct 926 IVEEQEIVPVVEQ---SQDVVVFTPADLEVVKETAEEVDEFILISAVPKEEVVSQEKEEP 982
Query 990 EIEPEPE------------------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSAN 1031
++E EP T E+P +F Y ++A V I K
Sbjct 983 QVEQEPTLVVKAQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLA---VVIAKALDEFK 1037
Query 1032 PMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK 1091
IVNAAN H+ HGGGVA A+ + DY+K +GP + +
Sbjct 1038 EFCIVNAANEHMSHGGGVAKAIADFCGPDFVEYCADYVKKHGPQQ---KLVTPSFVKGIQ 1094
Query 1092 CL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVR 1148
C+ +VVGP + L AAY++ ++ + P+LS+GIFG ++ + +R
Sbjct 1095 CVNNVVGPRHGDSNLREKLVAAYKSVLVGGVVNYVVPVLSSGIFGV----DFKISIDAMR 1150
Query 1149 TQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVD 1203
+ + + L + +++D KQ+ TED + +SVV KP D
Sbjct 1151 -EAFKGCAIRVLLFSLSQEHIDYFDATC---KQKTIYLTEDG-VKYRSVVLKPGD 1200
>sp|P0C6Y2|R1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain Beaudette CK) OX=160235 GN=rep
PE=3 SV=1
Length=6629
Score = 1093 bits (2827), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 746/2235 (33%), Positives = 1118/2235 (50%), Gaps = 211/2235 (9%)
Query 2256 MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFF 2315
+ +C F C +CL DSL Y +++ YK + G W Y++F F
Sbjct 1799 LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVFLILF 1853
Query 2316 Y--LLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIFFA 2365
+ G V Y + + NS +L WF V + + F
Sbjct 1854 VKPVAGF-----VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNFMG 1899
Query 2366 SFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRG 2420
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1900 AGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYN 1959
Query 2421 FCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHL 2480
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + ++L
Sbjct 1960 FCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFVNL 2019
Query 2481 YFDKAGQ-KTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVFDGKSKCDESAS------K 2532
+ A K + F D L+ A K +L I DG C+ ++ K
Sbjct 2020 KYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAK 2079
Query 2533 SASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVAT 2592
+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV T
Sbjct 2080 NAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD---------T 2129
Query 2593 AHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECLKLSHHSDLEVTGDSCNNF 2650
A G D +LS TKD ++ H+ D++ TGD N
Sbjct 2130 AALNYKAGTLRDALLSI---------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + V +W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPV--VWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTK--ISLKGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 A--VGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSE 2924
VG YT +I F TS + +A C ++ A P YC++ N G++ +
Sbjct 2409 REIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGS 2464
Query 2925 LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLN 2984
+ P Y +G + P L + VV YCR CE + G C+S + +WVL
Sbjct 2465 IIPHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLF 2523
Query 2985 NEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKF 3044
N+ Y + GVFCG L+ ++ + V ++ + +I ++V +KF
Sbjct 2524 NDEYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKF 2582
Query 3045 RRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQ 3104
+ VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2583 QGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCW 2642
Query 3105 WFAMFSPIVPFWITAIYVFCISLKHCH---WFFNNYLRKRVMFNGVTF-STFEEAALCTF 3160
F IVP W+ Y+ I + W + R +++G F ++ AA TF
Sbjct 2643 LVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTF 2702
Query 3161 LLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSN 3220
++ ++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + N
Sbjct 2703 VIRGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRN 2759
Query 3221 SGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR 3280
SG +++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPR
Sbjct 2760 SGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPR 2819
Query 3281 HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTP 3339
HV+ + D+L +NH F V + V L V+ ++ +L L+ +N +TP
Sbjct 2820 HVL---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETP 2876
Query 3340 KYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSF 3399
KYKF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F
Sbjct 2877 KYKFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNF 2936
Query 3400 CYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGD--- 3456
YMHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2937 FYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESS 2996
Query 3457 ----RWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELL 3512
+W L T +++D+N A + P + + LSA TG+ D+C L+ ++
Sbjct 2997 FSLPKW-LESTTVSVDDYNKWAGDNGFTPFSTSTA--ITKLSAITGV---DVCKLLRTIM 3050
Query 3513 --QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW-----MLLTFL 3565
+ G ILG EDE TP V Q GV Q F V+ W +L FL
Sbjct 3051 VKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFL 3107
Query 3566 TSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT-- 3623
L +V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3108 FVLCAIVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVI 3161
Query 3624 ------------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYAS 3664
V + + Y P + ++ W+ L + ++ ++ C M +
Sbjct 3162 IGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSF 3220
Query 3665 ALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGV 3724
LL+L + ++T N +T + GN W L +
Sbjct 3221 NTSLLMLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLA 3265
Query 3725 VTTIMFLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYF 3781
+ L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F
Sbjct 3266 NVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVF 3324
Query 3782 RLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSD 3841
LTLG Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SD
Sbjct 3325 GLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSD 3384
Query 3842 VKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGA 3901
VKCT+VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L +
Sbjct 3385 VKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDST 3444
Query 3902 VDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKL 3957
+D++ C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L
Sbjct 3445 IDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAY 3504
Query 3958 KKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKL 4017
+K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+
Sbjct 3505 RKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKI 3564
Query 4018 DNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQ 4077
D++ LN + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I
Sbjct 3565 DSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDT 3624
Query 4078 VVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQM 4129
V+DAD + + + N+AWPL V R V LQNNEL P ++
Sbjct 3625 VIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTK 3684
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
+C AG Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PP
Sbjct 3685 ACVAGVDQAHCSVESK-CYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPP 3742
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCA 4248
C+F +V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+
Sbjct 3743 CKFGMKVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCS 3802
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR
Sbjct 3803 FAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCR 3862
Query 4309 CHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
HI HP N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR
Sbjct 3863 AHIAHPGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLR 3921
Query 4365 EP---LMQSADASTF 4376
+P + A AS F
Sbjct 3922 QPKSSVQSVAGASDF 3936
Score = 65.1 bits (157), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/220 (26%), Positives = 95/220 (43%), Gaps = 14/220 (6%)
Query 1570 QFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNH 1629
QFG Y V + E K +P+ D EYY LD Y+ L
Sbjct 1202 QFGQVYAKNKIVFTAD---DVEDKEILYVPTTD---KSILEYY-GLDAQKYVIYLQTL-- 1252
Query 1630 TKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCA 1689
+KW ++W D NC++SS ++ LQ +++F L EA+ + GD +F A
Sbjct 1253 AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKG-FLTEAWAKLLGGDPTDFVA 1311
Query 1690 LILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN--VVCKHCGQKTTTLTGVEA-VM 1746
A VG+ D + +L +H + + L V C +CG K+ L G+EA +
Sbjct 1312 WCYASCTAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSC-NCGIKSYELRGLEACIQ 1370
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
+ + + KT S CG + T +++ ++++ A
Sbjct 1371 PVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFA 1410
Score = 49.7 bits (117), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 57/193 (30%), Positives = 83/193 (43%), Gaps = 29/193 (15%)
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
V I K IVNAAN H+ HG GVA A+ + +DY+K +GP
Sbjct 1025 VVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---- 1080
Query 1081 CLLSGHNLAK--KCL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAK 1135
L + K +C+ +VVGP + L AAY+N ++ + P+LS GIFG
Sbjct 1081 -RLVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD 1139
Query 1136 PLQSLQVCVQ-----TVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDS 1190
S+ + T+R ++ Q +DY D KQ+ TED
Sbjct 1140 FKMSIDAMREAFEGCTIRVLLFSL-------SQEHIDYFD------VTCKQKTIYLTEDG 1186
Query 1191 KTEEKSVVQKPVD 1203
+ +S+V KP D
Sbjct 1187 -VKYRSIVLKPGD 1198
>sp|P0C6Y1|R1AB_IBVB Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain Beaudette) OX=11122 GN=rep PE=1
SV=1
Length=6629
Score = 1093 bits (2827), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 746/2235 (33%), Positives = 1118/2235 (50%), Gaps = 211/2235 (9%)
Query 2256 MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFF 2315
+ +C F C +CL DSL Y +++ YK + G W Y++F F
Sbjct 1799 LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVFLILF 1853
Query 2316 Y--LLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIFFA 2365
+ G V Y + + NS +L WF V + + F
Sbjct 1854 VKPVAGF-----VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNFMG 1899
Query 2366 SFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRG 2420
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1900 AGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYN 1959
Query 2421 FCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHL 2480
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + ++L
Sbjct 1960 FCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFVNL 2019
Query 2481 YFDKAGQ-KTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVFDGKSKCDESAS------K 2532
+ A K + F D L+ A K +L I DG C+ ++ K
Sbjct 2020 KYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAK 2079
Query 2533 SASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVAT 2592
+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV T
Sbjct 2080 NAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD---------T 2129
Query 2593 AHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECLKLSHHSDLEVTGDSCNNF 2650
A G D +LS TKD ++ H+ D++ TGD N
Sbjct 2130 AALNYKAGTLRDALLSI---------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + V +W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAPPV--VWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTK--ISLKGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 A--VGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSE 2924
VG YT +I F TS + +A C ++ A P YC++ N G++ +
Sbjct 2409 REIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGS 2464
Query 2925 LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLN 2984
+ P Y +G + P L + VV YCR CE + G C+S + +WVL
Sbjct 2465 IIPHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLF 2523
Query 2985 NEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKF 3044
N+ Y + GVFCG L+ ++ + V ++ + +I ++V +KF
Sbjct 2524 NDEYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKF 2582
Query 3045 RRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQ 3104
+ VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2583 QGVFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCW 2642
Query 3105 WFAMFSPIVPFWITAIYVFCISLKHCH---WFFNNYLRKRVMFNGVTF-STFEEAALCTF 3160
F IVP W+ Y+ I + W + R +++G F ++ AA TF
Sbjct 2643 LVFTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTF 2702
Query 3161 LLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSN 3220
++ ++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + N
Sbjct 2703 VIRGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRN 2759
Query 3221 SGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR 3280
SG +++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPR
Sbjct 2760 SGVEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPR 2819
Query 3281 HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTP 3339
HV+ + D+L +NH F V + V L V+ ++ +L L+ +N +TP
Sbjct 2820 HVL---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETP 2876
Query 3340 KYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSF 3399
KYKF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F
Sbjct 2877 KYKFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNF 2936
Query 3400 CYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGD--- 3456
YMHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2937 FYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESS 2996
Query 3457 ----RWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELL 3512
+W L T +++D+N A + P + + LSA TG+ D+C L+ ++
Sbjct 2997 FSLPKW-LESTTVSVDDYNKWAGDNGFTPFSTSTA--ITKLSAITGV---DVCKLLRTIM 3050
Query 3513 --QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW-----MLLTFL 3565
+ G ILG EDE TP V Q GV Q F V+ W +L FL
Sbjct 3051 VKNSQWGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFL 3107
Query 3566 TSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT-- 3623
L +V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3108 FVLCAIVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVI 3161
Query 3624 ------------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYAS 3664
V + + Y P + ++ W+ L + ++ ++ C M +
Sbjct 3162 IGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSF 3220
Query 3665 ALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGV 3724
LL+L + ++T N +T + GN W L +
Sbjct 3221 NTSLLMLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLA 3265
Query 3725 VTTIMFLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYF 3781
+ L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F
Sbjct 3266 NVSSNSLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVF 3324
Query 3782 RLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSD 3841
LTLG Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SD
Sbjct 3325 GLTLGKYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSD 3384
Query 3842 VKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGA 3901
VKCT+VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L +
Sbjct 3385 VKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDST 3444
Query 3902 VDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKL 3957
+D++ C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L
Sbjct 3445 IDLSEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAY 3504
Query 3958 KKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKL 4017
+K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+
Sbjct 3505 RKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKI 3564
Query 4018 DNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQ 4077
D++ LN + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I
Sbjct 3565 DSEKLNVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDT 3624
Query 4078 VVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQM 4129
V+DAD + + + N+AWPL V R V LQNNEL P ++
Sbjct 3625 VIDADGTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTK 3684
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
+C AG Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PP
Sbjct 3685 ACVAGVDQAHCSVESK-CYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPP 3742
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCA 4248
C+F +V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+
Sbjct 3743 CKFGMKVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCS 3802
Query 4249 FAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCR 4308
FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR
Sbjct 3803 FAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCR 3862
Query 4309 CHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLR 4364
HI HP N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR
Sbjct 3863 AHIAHPGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLR 3921
Query 4365 EP---LMQSADASTF 4376
+P + A AS F
Sbjct 3922 QPKSSVQSVAGASDF 3936
Score = 65.1 bits (157), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 57/220 (26%), Positives = 95/220 (43%), Gaps = 14/220 (6%)
Query 1570 QFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNH 1629
QFG Y V + E K +P+ D EYY LD Y+ L
Sbjct 1202 QFGQVYAKNKIVFTAD---DVEDKEILYVPTTD---KSILEYY-GLDAQKYVIYLQTL-- 1252
Query 1630 TKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCA 1689
+KW ++W D NC++SS ++ LQ +++F L EA+ + GD +F A
Sbjct 1253 AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQAAKIRFKG-FLTEAWAKLLGGDPTDFVA 1311
Query 1690 LILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLN--VVCKHCGQKTTTLTGVEA-VM 1746
A VG+ D + +L +H + + L V C +CG K+ L G+EA +
Sbjct 1312 WCYASCTAKVGDFSDANWLLANLAEHFDADYTNAFLKKRVSC-NCGIKSYELRGLEACIQ 1370
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
+ + + KT S CG + T +++ ++++ A
Sbjct 1371 PVRATNLLHFKTQYSNCPTCGANNTDEVIEASLPYLLLFA 1410
Score = 49.7 bits (117), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 57/193 (30%), Positives = 83/193 (43%), Gaps = 29/193 (15%)
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
V I K IVNAAN H+ HG GVA A+ + +DY+K +GP
Sbjct 1025 VVIAKALDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---- 1080
Query 1081 CLLSGHNLAK--KCL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAK 1135
L + K +C+ +VVGP + L AAY+N ++ + P+LS GIFG
Sbjct 1081 -RLVTPSFVKGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD 1139
Query 1136 PLQSLQVCVQ-----TVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDS 1190
S+ + T+R ++ Q +DY D KQ+ TED
Sbjct 1140 FKMSIDAMREAFEGCTIRVLLFSL-------SQEHIDYFD------VTCKQKTIYLTEDG 1186
Query 1191 KTEEKSVVQKPVD 1203
+ +S+V KP D
Sbjct 1187 -VKYRSIVLKPGD 1198
>sp|P0C6Y3|R1AB_IBVM Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain M41) OX=11127 GN=rep PE=1 SV=1
Length=6631
Score = 1092 bits (2824), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 740/2229 (33%), Positives = 1119/2229 (50%), Gaps = 222/2229 (10%)
Query 2256 MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFF 2315
+ +C G F C +CL DSL Y +++ YK + G+ W Y++F F
Sbjct 1801 LRYCAGDFTCRVCLHDRDSLHLYKHAYSVE---QIYKDAAS--GINFNWNWLYLVFLILF 1855
Query 2316 ---------------YLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRM 2360
YL+ S ++Q G+ L WF V +
Sbjct 1856 VKPVAGFVIICYCVKYLVLSSTVLQTGVGF----------LDWF---------VKTVFTH 1896
Query 2361 YIFFASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
+ F + +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY
Sbjct 1897 FNFMGAGFYFWLFYKIYVQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYT 1956
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
N G FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++V V +
Sbjct 1957 NSGYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVYEACVVD 2016
Query 2476 GALHLYFDKA-GQKTYERHPLSHFVNLDNLR-ANNTKGSLPINVIVFDGKSKCDESAS-- 2531
++L + A K + F D L+ A K +L I DG C+ ++
Sbjct 2017 DFVNLKYKAAIPGKDNASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHA 2076
Query 2532 ----KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLK 2587
K+A+VYY+Q +C+PIL+LDQAL + VS + D S SV
Sbjct 2077 LEEAKNAAVYYAQYLCKPILILDQALYEQL-IVEPVSKSVIDKVCSILSNIISVD----- 2130
Query 2588 ALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD--VIECLKLSHHSDLEVTGD 2645
TA G D +LS TKD ++ H+ ++E TGD
Sbjct 2131 ----TAALNYKAGTLRDALLSI---------------TKDEEAVDMAIFCHNHEVEYTGD 2171
Query 2646 SCNNFMLTYN-KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRK 2704
N + +Y + +TPRD G I+ +A N +V + V +W D + LS+ K
Sbjct 2172 GFTNVIPSYGMDTDKLTPRDRGFLINADASIANLRVKNAPPV--VWKFSDLIKLSDSCLK 2229
Query 2705 QIRSAAKKNNIPFRLTCATTRQVVNVITTK--ISLKGGKIVS-------TCFKLMLKATL 2755
+ SA K+ F +T + +QV++ T K + K G +++ +CFK + +
Sbjct 2230 YLISATVKSGGRFFITKSGAKQVISCHTQKLLVEKKAGGVINNTFKWFMSCFKWLFVFYI 2289
Query 2756 LCVLAALVCYIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGF 2811
L A + Y M ++ +H Y T + G+K I GV R+I+S D+CF+NK F
Sbjct 2290 L-FTACCLGYYYMEMNKSFVHPMYDVNSTLHVEGFKVIDKGVIREIVSEDNCFSNKFVNF 2348
Query 2812 DAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------F 2861
DA++ G SY+N+K+CP+V +I + G + G+PG V ++G F+H +
Sbjct 2349 DAFW---GKSYENNKNCPIVTVVIDGD-GTVAVGVPGFVSWVMDGVMFVHMTQTDRRPWY 2404
Query 2862 LPRVFSA--VGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEG 2918
+P F+ VG YT +I F TS + +A C ++ A P YC++ N G
Sbjct 2405 IPTWFNREIVG---YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPG 2460
Query 2919 SISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTS 2978
++ + + P Y +G + P L + +V YCR CE ++ G C+S
Sbjct 2461 ALPFGSIIPHRVYFQPNGVRLIVPQQILH-TPYIVKFVSDSYCRGSVCEYTKPGYCVSLD 2519
Query 2979 GRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAA 3038
+WVL N+ Y + GVFCG L+ N+ + V ++ + +I +++
Sbjct 2520 SQWVLFNDEYISKPGVFCGSTVRELMFNMVSTFFTGVNP-NIYIQLATMFLILVVIVLIF 2578
Query 3039 YYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVS 3098
+KF+ VF Y +V L+++++ +LC+ S L + V Y Y + + + +
Sbjct 2579 AMVIKFQGVFKAYATIVFTIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASMVTSRNTA 2638
Query 3099 FLAHLQWFAMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEE 3154
+ H F IVP W+ Y+ I + W + R +++G F ++
Sbjct 2639 IIMHCWLVFTFGLIVPTWLACCYLGFILYMYTPLVFWCYGTTKNTRKLYDGNEFVGNYDL 2698
Query 3155 AALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKA 3214
AA TF++ ++KL +E ++ YL+ Y + KY+SG Y +A LA A
Sbjct 2699 AAKSTFVIRGTEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYA 2755
Query 3215 LNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDD 3274
L+ + NSG +V+Y PP+ SI + LQ+GF+K+ PS VE C+V V+ LNGLWL D
Sbjct 2756 LDQYRNSGVEVVYTPPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGD 2815
Query 3275 TVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDT 3333
++YCPRHV+ + D+L +NH F V N V L V+ ++ +L L+
Sbjct 2816 SIYCPRHVL---GKFSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAV 2872
Query 3334 SNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNID 3393
+N +TPKYKFV+ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+
Sbjct 2873 ANAETPKYKFVKANCGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIE 2932
Query 3394 YDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVI 3453
V+F YMHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I
Sbjct 2933 KGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAII 2992
Query 3454 N-------GDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA 3506
+ +W L T ++ D+N A + P + + LSA TG+ D+C
Sbjct 2993 SVKESSFSQPKW-LESTTVSIEDYNRWASDNGFTPFSTSTA--ITKLSAITGV---DVCK 3046
Query 3507 ALKELLQNGMNGRT--ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHW----- 3559
L+ ++ + ILG EDE TP V Q GV Q F V+ W
Sbjct 3047 LLRTIMVKSAQWGSDPILGQYNFEDELTPESVFNQVGGVRLQSSF---VRKATSWFWSRC 3103
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLP 3619
+L FL L +V T L F+V+ L +MA+ + VKH A++ FLLP
Sbjct 3104 VLACFLFVLCAIVLFTAVPLKFYVHAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLP 3157
Query 3620 SLATVA--------------------YFNMVYMPASWVMRIMTWLELADTSLSGYR-LKD 3658
+L TV + + Y P + ++ W+ L + ++ ++
Sbjct 3158 TLITVIIGVCAEVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMLLPLVLYTAFKCVQG 3216
Query 3659 CVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVT 3718
C M + LL+L + ++T N +T + GN W L +
Sbjct 3217 CYMNSFNTSLLMLYQ----FMKLGFVIYTSSNTLTAYTE---GN--------WELFFELV 3261
Query 3719 SNYSGVVTTIMFLARAIVFVCVE----YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLF 3774
+ L IVF C + Y + L +M+ +G+ C CYFGL+
Sbjct 3262 HTIVLANVSSNSLIGLIVFKCAKWMLYYCNATYFNNYVLMAVMV--NGIGWLCTCYFGLY 3319
Query 3775 CLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVAT 3834
+N+ F LTLG Y++ VS ++RYM + PPK+ + F NI + GIGG + +AT
Sbjct 3320 WWVNKVFGLTLGKYNFKVSVDQYRYMCLHKVNPPKTVWEVFTTNILIQGIGGDRVLPIAT 3379
Query 3835 VQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSV 3894
VQSK+SDVKCT+VVL+ +L +L VE++SK+ A V+LHN IL + D E + ++ +L
Sbjct 3380 VQSKLSDVKCTTVVLMQLLTKLNVEANSKMHAYLVELHNKILASDDVGECMDNLLGMLIT 3439
Query 3895 LLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDS 3950
L + +D+ C+++L LQ++ EFS +PSYA Y A+ YE+ +A+ G +
Sbjct 3440 LFCIDSTIDLGEYCDDILKRSTVLQSVTQEFSHIPSYAEYERAKSIYEKVLADSKNGGVT 3499
Query 3951 EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTML 4010
+ L +K+ N+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +L
Sbjct 3500 QQELAAYRKAANIAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALL 3559
Query 4011 FTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYAS 4070
F+ML+K+D++ LN + + A G VPL +P+ + KL +V+PD T+ +G TY++
Sbjct 3560 FSMLKKIDSEKLNVLFDQANSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYST 3619
Query 4071 ALWEIQQVVDADSKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELS 4122
+W I V DAD + + + N+AWPL V R V LQNNEL
Sbjct 3620 VVWNIDCVTDADGTELHPTSTGSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELM 3679
Query 4123 PVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTI 4182
P ++ +C AG Q C+ ++ YY + G V A+ S + +LK A F G I
Sbjct 3680 PHGVKTKACVAGVDQAHCSVESK-CYYTSISGSSVVAAITSSNPNLKVASFLNEAGN-QI 3737
Query 4183 YTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANS 4241
Y +L+PPC+F +V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE
Sbjct 3738 YVDLDPPCKFGMKVGDKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAV 3797
Query 4242 TVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGA 4301
+LS C+FAVDPA Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGA
Sbjct 3798 GILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGA 3857
Query 4302 SCCLYCRCHIDHP----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYG 4357
S CLYCR HI HP N G C KG +VQIPTT DPVGF LRN VCTVC W GYG
Sbjct 3858 SVCLYCRAHIAHPGGAGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYG 3916
Query 4358 CSCDQLREP 4366
C CD LR+P
Sbjct 3917 CQCDSLRQP 3925
Score = 70.1 bits (170), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 51/198 (26%), Positives = 90/198 (45%), Gaps = 9/198 (5%)
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
E K +P+ D E Y+ LD Y+ L +KW ++W D N
Sbjct 1222 EDKEILFIPTTDKTILE----YYGLDAQKYVTYLQTL--AQKWDVQYRDNFVILEWRDGN 1275
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
C++SS ++ LQ +++F L EA+ + GD +F A A N VG+ D +
Sbjct 1276 CWISSAIVLLQAAKIRFKG-FLAEAWAKLLGGDPTDFVAWCYASCNAKVGDFSDANWLLA 1334
Query 1711 HLLQHANLESAKRVL-NVVCKHCGQKTTTLTGVEA-VMYMGTLSYDNLKTGVSIPCVCGR 1768
+L +H + + +L V +CG K+ L G+EA + + + + KT S CG
Sbjct 1335 NLAEHFDADYTNALLKKCVSCNCGVKSYELRGLEACIQPVRAPNLLHFKTQYSNCPTCGA 1394
Query 1769 DATQYLVQQESSFVMMSA 1786
+T +++ ++++ A
Sbjct 1395 SSTDEVIEASLPYLLLFA 1412
Score = 55.1 bits (131), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 88/355 (25%), Positives = 140/355 (39%), Gaps = 53/355 (15%)
Query 878 EAVVKTL-QPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
E VK L Q V D+L + G +D A L S + F + + A
Sbjct 870 EGAVKALPQKVIDVLGDWGEAVD----AQEQLCQQESTRVISEKSVEGFTGSCDAMAEQA 925
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEE-------EEEDWLDDTTEQS 989
EE+EI E ++D P + ET +E +E+ + E+
Sbjct 926 IVEEQEIVPVVEQ---SQDVVVFTPADLEVVKETAEEVDEFILISAVPKEEVVSQEKEEP 982
Query 990 EIEPEPE------------------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSAN 1031
++E EP T E+P +F Y ++A V I K
Sbjct 983 QVEQEPTLVVKAQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLA---VVIAKALDEFK 1037
Query 1032 PMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK 1091
IVNAAN H+ HGGGVA A+ + DY+K +GP + +
Sbjct 1038 EFCIVNAANEHMSHGGGVAKAIADFCGPDFVEYCADYVKKHGPQQ---KLVTPSFVKGIQ 1094
Query 1092 CL-HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVR 1148
C+ +VVGP + L AAY++ ++ + P+LS+GIFG ++ + +R
Sbjct 1095 CVNNVVGPRHGDSNLREKLVAAYKSVLVGGVVNYVVPVLSSGIFGV----DFKISIDAMR 1150
Query 1149 TQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVD 1203
+ + + L + +++D KQ+ TED + +SVV KP D
Sbjct 1151 -EAFKGCAIRVLLFSLSQEHIDYFDATC---KQKTIYLTEDG-VKYRSVVLKPGD 1200
>sp|P0C6T4|R1A_BCHK4 Replicase polyprotein 1a OS=Bat coronavirus
HKU4 OX=694007 GN=1a PE=1 SV=1
Length=4434
Score = 311 bits (797), Expect = 7e-83, Method: Compositional matrix adjust.
Identities = 234/757 (31%), Positives = 363/757 (48%), Gaps = 55/757 (7%)
Query 1381 KYKGIKIQEGI--VDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEA 1438
+ KG+ + I VD GV ++ Y++++ + +I N + + MP GYVTHG +L ++
Sbjct 1357 RTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCSG-ICAMPFGYVTHGLDLAQS 1414
Query 1439 ARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SGQRT 1497
+R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1415 GNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSGDLI 1472
Query 1498 ELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIK 1546
V + K G I Y + +++ V L+ ++ L+ R + I+
Sbjct 1473 VKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQVNIE 1528
Query 1547 VFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRS 1606
V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +D+ S
Sbjct 1529 VLVTIDGVNFRTVILNDTTTFRKQLGATFYKGVDISDAFPTVKMGGESLFV--ADNLSES 1586
Query 1607 EAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL 1663
E EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ + L
Sbjct 1587 EKVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDML 1646
Query 1664 -EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SA 1721
++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L SA
Sbjct 1647 HDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSA 1706
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
K V C CG + TG+ A +Y G S + L++ + CVCG + LV+ + +
Sbjct 1707 KMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSAPW 1766
Query 1782 VMMSAPPAEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
+++S E K+ T + N + G GHY HI K+ L Y+ D LTK S+
Sbjct 1767 LLVSGL-NEVKVSTSTDPIYRAFNVFQGVETSVGHYVHIRVKDGLFYKYDSGSLTKTSDM 1825
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1826 KCKMTSVWYPTVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1885
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1886 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1945
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1946 FSNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2005
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTE---VVGNVILKPSDEGVKVTQ 2065
+Q E P ++V P +++IE K V GN GV V
Sbjct 2006 TSQ-----LVEHNVPVVDDV---PITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2057
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIAT 2101
LG +L A YV+ NT + + N S L T+ +
Sbjct 2058 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVES 2094
Score = 176 bits (445), Expect = 7e-42, Method: Compositional matrix adjust.
Identities = 263/1074 (24%), Positives = 438/1074 (41%), Gaps = 134/1074 (12%)
Query 9 NEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGVL 61
NEK HV ++P+ D+ L F D E A ++ LK G V + + +
Sbjct 22 NEKRSDHVACTVPLCDTDDMACKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRAM 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGIT---LGVLVPHVGETPI 116
L P V++ H +V +A D G R+ + LG+ P+
Sbjct 81 KFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDQVGAAMMRTTLNAKPLGMFFPYDSSLET 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALREL 173
LLRKNG G D K ++ D+L DP Y QN L
Sbjct 141 GEYTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------L 188
Query 174 TRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSE-QLDY---IESKRGVY 229
++L GG +D CG +G P+ +A+ G + TL++ ++D ++S R +
Sbjct 189 LKKLIGGDCIP-IDQYMCGKNGKPIADYAKIVAKEG--LTTLADIEVDVKSRMDSDRFI- 244
Query 230 CCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RV 288
+ + W R + Y QT F I S + D K P+ F + S++ ++ P +
Sbjct 245 VLNKKLYRVVWNVTRRNVPYPKQTAFTIVSVVQCDD-KDSVPEHTFTIGSQILMVSPLKA 303
Query 289 EKKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTE 347
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 304 TNNKNFNLKQRLLYTFYGKDAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGAN 363
Query 348 NLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TR 404
+ + G +P NA+ CP + HS A +N + + + GG+ T
Sbjct 364 YSANDVDLQSSGLVPRNALFLANCPCANNGAC--SHSAAQVYNILDGKACVEVGGKSFTL 421
Query 405 CFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRE 457
FGG V+AY+GC + Y+VPRA + I +G TG VET N L +
Sbjct 422 TFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKA 477
Query 458 RVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGK 515
+ ++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 478 QRSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGD 534
Query 516 PVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISE 575
++ A NIG V P A + F + +L+ A LD S
Sbjct 535 YIRDAINIGAN-GVCNATINAPFIAFTGLGESFKKVSAIPWKICSNLKSA----LDYYSS 589
Query 576 QSLRLV-------DAMVYTSDLLTNSVIIMA---YVTGGLVQQTSQWLSNLLGTTVEKLR 625
+ V D + LL + +A +V L ++ L + L
Sbjct 590 NIMFRVFPYDIPCDVSNFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTVSSACQTALS 649
Query 626 PIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVK-GQIQVASDNIKDCVKCFIDVVNK 684
A A F+ D +++ K L+ ++ G + VA + K V+ +D+++K
Sbjct 650 SFLNACVAASRATAGFINDMFKLFKVLMHKLYVYTSCGYVAVAEHSSK-IVQQVLDIMSK 708
Query 685 ALEMCIDQVTIAGAKLRSL----------NLGEVFIAQSKGLYRQCIRGKEQLQLLMPLK 734
A+++ V+ AG KL ++ N G F +K + ++G Q+ L++P
Sbjct 709 AMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKA---KTLQG--QMNLVLPGD 763
Query 735 APKEVTFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLM 789
K+ + D+ D S V + +G+LE P + IVG V V+ +
Sbjct 764 YNKKTLGILDPVPNADTIDVNANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKL 819
Query 790 LLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDER 849
+ +D+E Y + G + + +FRLKGG P K VTFG+ EV Y++V IT+++
Sbjct 820 FVRTEDEEFYPLCTNGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPV 878
Query 850 VDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYL 908
+D +L + K + +TVE V +F V+ + V+ L P+ G D++++ Y+
Sbjct 879 LDALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYV 938
Query 909 FDDAGEENFSSRMYCSFYP-----------------------PDEEEEDDAECEEEEIDE 945
++ G+ +SS M S P DEE A E +D+
Sbjct 939 YNQDGDCAWSSNMTFSINPVEDVEEVEEFIEDDYLSDELPIADDEEAWARAVEEVMPLDD 998
Query 946 TCEHEYGTEDDYQGLPLEFG---ASAETVRVEEEEEE--DWLDDTTEQSEIEPE 994
E E+D PLE AE V E +E + +D T S + E
Sbjct 999 ILVAEIELEED---PPLETALESVEAEVVETAEAQEPSVESIDSTPSTSTVVGE 1049
Score = 133 bits (334), Expect = 5e-29, Method: Compositional matrix adjust.
Identities = 75/188 (40%), Positives = 105/188 (56%), Gaps = 6/188 (3%)
Query 960 LPLEFGASAETV-RVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLK-----LT 1013
LP++ AS V +V + + + L T+ ++P + P K +
Sbjct 1103 LPIQDEASENQVHQVSDLQGNELLCSETKVEIVQPRQDLKPRRSRKSKVDLSKYKHTVIN 1162
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
++V + D ++ A ++VNAAN HLKHGGG+AG +NKA+ G +Q+ESD+YI NG
Sbjct 1163 NSVTLVLGDAIQIASLLPKCILVNAANRHLKHGGGIAGVINKASGGDVQEESDEYISNNG 1222
Query 1074 PLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFG 1133
PL VG S LL GH LA LHVVGP+ ED LLK Y+ FN I++ PL+SAGIF
Sbjct 1223 PLHVGDSVLLKGHGLADAILHVVGPDARNNEDAALLKRCYKAFNKHTIVVTPLISAGIFS 1282
Query 1134 AKPLQSLQ 1141
P S +
Sbjct 1283 VDPKVSFE 1290
>sp|P0C6W3|R1AB_BCHK4 Replicase polyprotein 1ab OS=Bat coronavirus
HKU4 OX=694007 GN=rep PE=1 SV=1
Length=7119
Score = 310 bits (795), Expect = 1e-82, Method: Compositional matrix adjust.
Identities = 234/757 (31%), Positives = 363/757 (48%), Gaps = 55/757 (7%)
Query 1381 KYKGIKIQEGI--VDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEA 1438
+ KG+ + I VD GV ++ Y++++ + +I N + + MP GYVTHG +L ++
Sbjct 1357 RTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCSG-ICAMPFGYVTHGLDLAQS 1414
Query 1439 ARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SGQRT 1497
+R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1415 GNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSGDLI 1472
Query 1498 ELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIK 1546
V + K G I Y + +++ V L+ ++ L+ R + I+
Sbjct 1473 VKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQVNIE 1528
Query 1547 VFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRS 1606
V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +D+ S
Sbjct 1529 VLVTIDGVNFRTVILNDTTTFRKQLGATFYKGVDISDAFPTVKMGGESLFV--ADNLSES 1586
Query 1607 EAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL 1663
E EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ + L
Sbjct 1587 EKVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDML 1646
Query 1664 -EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SA 1721
++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L SA
Sbjct 1647 HDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSA 1706
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
K V C CG + TG+ A +Y G S + L++ + CVCG + LV+ + +
Sbjct 1707 KMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSAPW 1766
Query 1782 VMMSAPPAEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
+++S E K+ T + N + G GHY HI K+ L Y+ D LTK S+
Sbjct 1767 LLVSGL-NEVKVSTSTDPIYRAFNVFQGVETSVGHYVHIRVKDGLFYKYDSGSLTKTSDM 1825
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1826 KCKMTSVWYPTVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1885
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1886 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1945
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1946 FSNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2005
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTE---VVGNVILKPSDEGVKVTQ 2065
+Q E P ++V P +++IE K V GN GV V
Sbjct 2006 TSQ-----LVEHNVPVVDDV---PITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2057
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIAT 2101
LG +L A YV+ NT + + N S L T+ +
Sbjct 2058 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVES 2094
Score = 176 bits (445), Expect = 7e-42, Method: Compositional matrix adjust.
Identities = 263/1074 (24%), Positives = 438/1074 (41%), Gaps = 134/1074 (12%)
Query 9 NEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGVL 61
NEK HV ++P+ D+ L F D E A ++ LK G V + + +
Sbjct 22 NEKRSDHVACTVPLCDTDDMACKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRAM 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGIT---LGVLVPHVGETPI 116
L P V++ H +V +A D G R+ + LG+ P+
Sbjct 81 KFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDQVGAAMMRTTLNAKPLGMFFPYDSSLET 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALREL 173
LLRKNG G D K ++ D+L DP Y QN L
Sbjct 141 GEYTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------L 188
Query 174 TRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSE-QLDY---IESKRGVY 229
++L GG +D CG +G P+ +A+ G + TL++ ++D ++S R +
Sbjct 189 LKKLIGGDCIP-IDQYMCGKNGKPIADYAKIVAKEG--LTTLADIEVDVKSRMDSDRFI- 244
Query 230 CCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RV 288
+ + W R + Y QT F I S + D K P+ F + S++ ++ P +
Sbjct 245 VLNKKLYRVVWNVTRRNVPYPKQTAFTIVSVVQCDD-KDSVPEHTFTIGSQILMVSPLKA 303
Query 289 EKKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTE 347
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 304 TNNKNFNLKQRLLYTFYGKDAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGAN 363
Query 348 NLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TR 404
+ + G +P NA+ CP + HS A +N + + + GG+ T
Sbjct 364 YSANDVDLQSSGLVPRNALFLANCPCANNGAC--SHSAAQVYNILDGKACVEVGGKSFTL 421
Query 405 CFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRE 457
FGG V+AY+GC + Y+VPRA + I +G TG VET N L +
Sbjct 422 TFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKA 477
Query 458 RVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGK 515
+ ++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 478 QRSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGD 534
Query 516 PVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISE 575
++ A NIG V P A + F + +L+ A LD S
Sbjct 535 YIRDAINIGAN-GVCNATINAPFIAFTGLGESFKKVSAIPWKICSNLKSA----LDYYSS 589
Query 576 QSLRLV-------DAMVYTSDLLTNSVIIMA---YVTGGLVQQTSQWLSNLLGTTVEKLR 625
+ V D + LL + +A +V L ++ L + L
Sbjct 590 NIMFRVFPYDIPCDVSNFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTVSSACQTALS 649
Query 626 PIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVK-GQIQVASDNIKDCVKCFIDVVNK 684
A A F+ D +++ K L+ ++ G + VA + K V+ +D+++K
Sbjct 650 SFLNACVAASRATAGFINDMFKLFKVLMHKLYVYTSCGYVAVAEHSSK-IVQQVLDIMSK 708
Query 685 ALEMCIDQVTIAGAKLRSL----------NLGEVFIAQSKGLYRQCIRGKEQLQLLMPLK 734
A+++ V+ AG KL ++ N G F +K + ++G Q+ L++P
Sbjct 709 AMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKA---KTLQG--QMNLVLPGD 763
Query 735 APKEVTFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLM 789
K+ + D+ D S V + +G+LE P + IVG V V+ +
Sbjct 764 YNKKTLGILDPVPNADTIDVNANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKL 819
Query 790 LLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDER 849
+ +D+E Y + G + + +FRLKGG P K VTFG+ EV Y++V IT+++
Sbjct 820 FVRTEDEEFYPLCTNGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPV 878
Query 850 VDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYL 908
+D +L + K + +TVE V +F V+ + V+ L P+ G D++++ Y+
Sbjct 879 LDALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYV 938
Query 909 FDDAGEENFSSRMYCSFYP-----------------------PDEEEEDDAECEEEEIDE 945
++ G+ +SS M S P DEE A E +D+
Sbjct 939 YNQDGDCAWSSNMTFSINPVEDVEEVEEFIEDDYLSDELPIADDEEAWARAVEEVMPLDD 998
Query 946 TCEHEYGTEDDYQGLPLEFG---ASAETVRVEEEEEE--DWLDDTTEQSEIEPE 994
E E+D PLE AE V E +E + +D T S + E
Sbjct 999 ILVAEIELEED---PPLETALESVEAEVVETAEAQEPSVESIDSTPSTSTVVGE 1049
Score = 133 bits (334), Expect = 6e-29, Method: Compositional matrix adjust.
Identities = 75/188 (40%), Positives = 105/188 (56%), Gaps = 6/188 (3%)
Query 960 LPLEFGASAETV-RVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLK-----LT 1013
LP++ AS V +V + + + L T+ ++P + P K +
Sbjct 1103 LPIQDEASENQVHQVSDLQGNELLCSETKVEIVQPRQDLKPRRSRKSKVDLSKYKHTVIN 1162
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
++V + D ++ A ++VNAAN HLKHGGG+AG +NKA+ G +Q+ESD+YI NG
Sbjct 1163 NSVTLVLGDAIQIASLLPKCILVNAANRHLKHGGGIAGVINKASGGDVQEESDEYISNNG 1222
Query 1074 PLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFG 1133
PL VG S LL GH LA LHVVGP+ ED LLK Y+ FN I++ PL+SAGIF
Sbjct 1223 PLHVGDSVLLKGHGLADAILHVVGPDARNNEDAALLKRCYKAFNKHTIVVTPLISAGIFS 1282
Query 1134 AKPLQSLQ 1141
P S +
Sbjct 1283 VDPKVSFE 1290
>sp|P0C6F7|R1A_BC133 Replicase polyprotein 1a OS=Bat coronavirus
133/2005 OX=389230 GN=1a PE=3 SV=1
Length=4441
Score = 308 bits (790), Expect = 5e-82, Method: Compositional matrix adjust.
Identities = 233/757 (31%), Positives = 363/757 (48%), Gaps = 55/757 (7%)
Query 1381 KYKGIKIQEGI--VDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEA 1438
+ KG+ + I VD GV ++ Y++++ + +I N + MP GYVTHG +L ++
Sbjct 1364 RTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGC-PGICAMPFGYVTHGLDLAQS 1421
Query 1439 ARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SGQRT 1497
+R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1422 GNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSGDLI 1479
Query 1498 ELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIK 1546
V + K G I Y + +++ V L+ ++ L+ R + I+
Sbjct 1480 VKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQVNIE 1535
Query 1547 VFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRS 1606
V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +D+ S
Sbjct 1536 VLVTIDGVNFRTVILNDATTFRKQLGATFYKGVDISDALPTVKMGGESLFV--ADNLSES 1593
Query 1607 EAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL 1663
E EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ + L
Sbjct 1594 EEVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDML 1653
Query 1664 -EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SA 1721
++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L SA
Sbjct 1654 HDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSA 1713
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
K V C CG + TG+ A +Y G S + L++ + CVCG + LV+ + +
Sbjct 1714 KMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSTPW 1773
Query 1782 VMMSAPPAEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
+++S E K+ T + N + G GHY H+ K+ L Y+ D LTK S+
Sbjct 1774 LLVSGL-NEVKVSTSTDPVYRAFNVFQGVETSVGHYVHVRVKDGLFYKYDSGSLTKTSDM 1832
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y + YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1833 KCKMTSVWYPKVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1892
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1893 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1952
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1953 FNNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2012
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTE---VVGNVILKPSDEGVKVTQ 2065
+Q + E P E+V +++IE K V GN GV V
Sbjct 2013 TSQLI-----EPNVPVVEDV---SITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2064
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIAT 2101
LG +L A YV+ NT + + N S L T+ +
Sbjct 2065 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVES 2101
Score = 174 bits (442), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 261/1084 (24%), Positives = 440/1084 (41%), Gaps = 152/1084 (14%)
Query 9 NEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGVL 61
NEK HV ++P+ D+ L F D E A ++ LK G V + + +
Sbjct 22 NEKRSDHVACTVPLCDTEDMASKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRAM 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGIT---LGVLVPHVGETPI 116
L P V++ H +V +A D G R+ + LG+ P+
Sbjct 81 KFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDHVGAAMMRTTLNVKPLGMFFPYDSSLET 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALREL 173
LLRKNG G D K ++ D+L DP Y QN L
Sbjct 141 GEHTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------L 188
Query 174 TRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSE-QLDY---IESKRGVY 229
++L GG VD CG +G P+ +A+ G + TL++ ++D ++S R +
Sbjct 189 LKKLIGGDCIP-VDQYMCGKNGKPIADYAKIVAKEG--LTTLADIEVDVKSRMDSDRFI- 244
Query 230 CCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RV 288
+ + W R + Y QT F + S + D K P+ F + S++ ++ P +
Sbjct 245 VLNKKLYRVVWNVTRRNVPYSKQTAFTVVSVIQCDD-KESVPEHTFTIGSQILMVSPLKA 303
Query 289 EKKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTE 347
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 304 TNNKNFNLKQRLLHTFYGKEAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGAN 363
Query 348 NLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TR 404
+ + G +P NA+ CP + H+ A ++ + + + GG+ T
Sbjct 364 YSANDVDLQSSGLVPKNALFLANCPCANNGAC--SHNAAQVYSILDGKACVEVGGKSFTL 421
Query 405 CFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRE 457
FGG V+AY+GC + Y+VPRA + I +G TG VET N L +
Sbjct 422 TFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKA 477
Query 458 RVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGK 515
+ ++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 478 QHSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGD 534
Query 516 PVKGAWNIGQ----QRSVLTPLCGFPS------QAAGVIRSIFARTLDAANHSIPDLQRA 565
++ A NIG ++ P F + A + I + A ++ ++
Sbjct 535 YIRDAINIGANGVCNATINAPFIAFTGLGESFKKVAAIPWKICSNLKSALDYYCSNIMFR 594
Query 566 AV--TILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-------VTGGLVQQTSQWLSNL 616
I +++ L+D T + S ++ Y V G + LS+
Sbjct 595 VFPYDIPCDVNDFVELLLDCGKLT---VATSYFVLRYLDEKFDTVLGTVSNACQTALSSF 651
Query 617 LGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVK-GQIQVASDNIKDCV 675
L V R A F+ D +++ K L+ ++ G + VA + K V
Sbjct 652 LNACVAASR-----------ATAGFISDMFKLFKVLMHKLYVYTSCGYVAVAEHSSK-IV 699
Query 676 KCFIDVVNKALEMCIDQVTIAGAKLRSL----------NLGEVFIAQSKGLYRQCIRGKE 725
+ +D+++KA+++ V+ AG KL ++ N G F +K Q +
Sbjct 700 QQVLDIMSKAMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQ-----D 754
Query 726 QLQLLMPLKAPKEVTFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Q+ L++P K+ + D+ D S V + +G+LE P + IVG
Sbjct 755 QMNLVLPGDYNKKTLGILDPVPNADTIDVTANSTVVDVVHGQLE----PTNEHGPSMIVG 810
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
V V+ + + D+E Y G + + +FRLKGG P K VTFG+ EV Y++V
Sbjct 811 NYVLVSDKLFVRTDDEEFYPLCINGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSV 869
Query 841 RITFELDERVDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLD 899
IT+++ +D +L + K + +TVE V +F V+ + V+ L P+ G D++
Sbjct 870 SITYDIHPVLDALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVE 929
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYP-----------------------PDEEEEDDA 936
++ Y+++ G+ +SS M S P DEE A
Sbjct 930 DFIDVPCYVYNQDGDCAWSSNMTFSINPVEDVEEVEEFIEDDYLSDELPIADDEEAWTRA 989
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPE 996
E +D+ E E+D LPLE + E+V E E + D E E
Sbjct 990 VEEVMPLDDILVAEIELEED---LPLE--TALESVEAEVGES---ISDELCVVETAKAQE 1041
Query 997 PTPE 1000
P+ E
Sbjct 1042 PSVE 1045
Score = 124 bits (310), Expect = 3e-26, Method: Compositional matrix adjust.
Identities = 62/130 (48%), Positives = 84/130 (65%), Gaps = 0/130 (0%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ ++V + D ++ A V+VNAAN HLKHGGG+AGA+NKA+ G +Q+ESD+YI
Sbjct 1168 INNSVTLVLGDAIQIASLLPKCVLVNAANRHLKHGGGIAGAINKASGGDVQEESDEYISN 1227
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGI 1131
+GPL VG S LL G+ LA L VVGP+ ED LLK Y+ FN I++ PL+S+GI
Sbjct 1228 SGPLHVGDSVLLKGYGLADAILRVVGPDARNNEDAALLKRCYKTFNKHTIVVTPLISSGI 1287
Query 1132 FGAKPLQSLQ 1141
F P S +
Sbjct 1288 FSVDPKVSFE 1297
>sp|P0C6W1|R1AB_BC133 Replicase polyprotein 1ab OS=Bat coronavirus
133/2005 OX=389230 GN=rep PE=3 SV=1
Length=7126
Score = 308 bits (790), Expect = 5e-82, Method: Compositional matrix adjust.
Identities = 233/757 (31%), Positives = 363/757 (48%), Gaps = 55/757 (7%)
Query 1381 KYKGIKIQEGI--VDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEA 1438
+ KG+ + I VD GV ++ Y++++ + +I N + MP GYVTHG +L ++
Sbjct 1364 RTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGC-PGICAMPFGYVTHGLDLAQS 1421
Query 1439 ARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SGQRT 1497
+R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1422 GNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSGDLI 1479
Query 1498 ELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIK 1546
V + K G I Y + +++ V L+ ++ L+ R + I+
Sbjct 1480 VKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQVNIE 1535
Query 1547 VFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRS 1606
V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +D+ S
Sbjct 1536 VLVTIDGVNFRTVILNDATTFRKQLGATFYKGVDISDALPTVKMGGESLFV--ADNLSES 1593
Query 1607 EAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQL 1663
E EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ + L
Sbjct 1594 EEVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDML 1653
Query 1664 -EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SA 1721
++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L SA
Sbjct 1654 HDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVSA 1713
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
K V C CG + TG+ A +Y G S + L++ + CVCG + LV+ + +
Sbjct 1714 KMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSTPW 1773
Query 1782 VMMSAPPAEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
+++S E K+ T + N + G GHY H+ K+ L Y+ D LTK S+
Sbjct 1774 LLVSGL-NEVKVSTSTDPVYRAFNVFQGVETSVGHYVHVRVKDGLFYKYDSGSLTKTSDM 1832
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y + YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1833 KCKMTSVWYPKVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1892
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1893 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1952
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1953 FNNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2012
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTE---VVGNVILKPSDEGVKVTQ 2065
+Q + E P E+V +++IE K V GN GV V
Sbjct 2013 TSQLI-----EPNVPVVEDV---SITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2064
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIAT 2101
LG +L A YV+ NT + + N S L T+ +
Sbjct 2065 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVES 2101
Score = 176 bits (445), Expect = 6e-42, Method: Compositional matrix adjust.
Identities = 261/1084 (24%), Positives = 440/1084 (41%), Gaps = 152/1084 (14%)
Query 9 NEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGVL 61
NEK HV ++P+ D+ L F D E A ++ LK G V + + +
Sbjct 22 NEKRSDHVACTVPLCDTEDMASKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRAM 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGIT---LGVLVPHVGETPI 116
L P V++ H +V +A D G R+ + LG+ P+
Sbjct 81 KFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDHVGAAMMRTTLNVKPLGMFFPYDSSLET 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALREL 173
LLRKNG G D K ++ D+L DP Y QN L
Sbjct 141 GEHTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------L 188
Query 174 TRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSE-QLDY---IESKRGVY 229
++L GG VD CG +G P+ +A+ G + TL++ ++D ++S R +
Sbjct 189 LKKLIGGDCIP-VDQYMCGKNGKPIADYAKIVAKEG--LTTLADIEVDVKSRMDSDRFI- 244
Query 230 CCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RV 288
+ + W R + Y QT F + S + D K P+ F + S++ ++ P +
Sbjct 245 VLNKKLYRVVWNVTRRNVPYSKQTAFTVVSVIQCDD-KESVPEHTFTIGSQILMVSPLKA 303
Query 289 EKKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTE 347
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 304 TNNKNFNLKQRLLHTFYGKEAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGAN 363
Query 348 NLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TR 404
+ + G +P NA+ CP + H+ A ++ + + + GG+ T
Sbjct 364 YSANDVDLQSSGLVPKNALFLANCPCANNGAC--SHNAAQVYSILDGKACVEVGGKSFTL 421
Query 405 CFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRE 457
FGG V+AY+GC + Y+VPRA + I +G TG VET N L +
Sbjct 422 TFGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKA 477
Query 458 RVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGK 515
+ ++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 478 QHSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGD 534
Query 516 PVKGAWNIGQ----QRSVLTPLCGFPS------QAAGVIRSIFARTLDAANHSIPDLQRA 565
++ A NIG ++ P F + A + I + A ++ ++
Sbjct 535 YIRDAINIGANGVCNATINAPFIAFTGLGESFKKVAAIPWKICSNLKSALDYYCSNIMFR 594
Query 566 AV--TILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-------VTGGLVQQTSQWLSNL 616
I +++ L+D T + S ++ Y V G + LS+
Sbjct 595 VFPYDIPCDVNDFVELLLDCGKLT---VATSYFVLRYLDEKFDTVLGTVSNACQTALSSF 651
Query 617 LGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVK-GQIQVASDNIKDCV 675
L V R A F+ D +++ K L+ ++ G + VA + K V
Sbjct 652 LNACVAASR-----------ATAGFISDMFKLFKVLMHKLYVYTSCGYVAVAEHSSK-IV 699
Query 676 KCFIDVVNKALEMCIDQVTIAGAKLRSL----------NLGEVFIAQSKGLYRQCIRGKE 725
+ +D+++KA+++ V+ AG KL ++ N G F +K Q +
Sbjct 700 QQVLDIMSKAMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQ-----D 754
Query 726 QLQLLMPLKAPKEVTFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Q+ L++P K+ + D+ D S V + +G+LE P + IVG
Sbjct 755 QMNLVLPGDYNKKTLGILDPVPNADTIDVTANSTVVDVVHGQLE----PTNEHGPSMIVG 810
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
V V+ + + D+E Y G + + +FRLKGG P K VTFG+ EV Y++V
Sbjct 811 NYVLVSDKLFVRTDDEEFYPLCINGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSV 869
Query 841 RITFELDERVDKVL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLD 899
IT+++ +D +L + K + +TVE V +F V+ + V+ L P+ G D++
Sbjct 870 SITYDIHPVLDALLSSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVE 929
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYP-----------------------PDEEEEDDA 936
++ Y+++ G+ +SS M S P DEE A
Sbjct 930 DFIDVPCYVYNQDGDCAWSSNMTFSINPVEDVEEVEEFIEDDYLSDELPIADDEEAWTRA 989
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPE 996
E +D+ E E+D LPLE + E+V E E + D E E
Sbjct 990 VEEVMPLDDILVAEIELEED---LPLE--TALESVEAEVGES---ISDELCVVETAKAQE 1041
Query 997 PTPE 1000
P+ E
Sbjct 1042 PSVE 1045
Score = 124 bits (311), Expect = 3e-26, Method: Compositional matrix adjust.
Identities = 62/130 (48%), Positives = 84/130 (65%), Gaps = 0/130 (0%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ ++V + D ++ A V+VNAAN HLKHGGG+AGA+NKA+ G +Q+ESD+YI
Sbjct 1168 INNSVTLVLGDAIQIASLLPKCVLVNAANRHLKHGGGIAGAINKASGGDVQEESDEYISN 1227
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGI 1131
+GPL VG S LL G+ LA L VVGP+ ED LLK Y+ FN I++ PL+S+GI
Sbjct 1228 SGPLHVGDSVLLKGYGLADAILRVVGPDARNNEDAALLKRCYKTFNKHTIVVTPLISSGI 1287
Query 1132 FGAKPLQSLQ 1141
F P S +
Sbjct 1288 FSVDPKVSFE 1297
>sp|Q97UU4|Y2899_SACS2 Uncharacterized protein SSO2899 OS=Saccharolobus
solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322
/ P2) OX=273057 GN=SSO2899 PE=4 SV=1
Length=177
Score = 68.2 bits (165), Expect = 5e-11, Method: Composition-based stats.
Identities = 45/106 (42%), Positives = 61/106 (58%), Gaps = 8/106 (8%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN +L+HGGGVA A+ + +QKESD+Y+K GP+ VG + S L AK +
Sbjct 25 IVNAANSYLQHGGGVAYAIVRKGGYIIQKESDEYVKKFGPVPVGEVAVTSAGKLKAKYVI 84
Query 1094 HVVGPNLN-AGEDIQLLKAAYENFNSQDIL-----LAPLLSAGIFG 1133
H VGP GED +L A +++ D L P +S GI+G
Sbjct 85 HAVGPRYGIEGED-KLESAIFKSLLKADELSLSSIAMPAISTGIYG 129
>sp|Q8ZXT3|Y1111_PYRAE Uncharacterized protein PAE1111 OS=Pyrobaculum
aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630
/ CIP 104966 / NBRC 100827 / IM2) OX=178306 GN=PAE1111 PE=4
SV=1
Length=182
Score = 68.2 bits (165), Expect = 5e-11, Method: Composition-based stats.
Identities = 42/106 (40%), Positives = 63/106 (59%), Gaps = 8/106 (8%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN +L+HGGGVAGA+ + +Q+ES ++++ +GP+ VG + S L AK +
Sbjct 25 IVNAANSYLEHGGGVAGAIVRKGGQVIQEESREWVRKHGPVPVGDVAVTSAGRLKAKYVI 84
Query 1094 HVVGPNLNAGEDIQLLKAAYEN--FNSQDILLA----PLLSAGIFG 1133
H VGP E I+ L A +N ++++ L P +S GIFG
Sbjct 85 HAVGPRCGV-EPIEKLAEAVKNALLKAEELGLVSIALPAISTGIFG 129
>sp|Q9WYX8|Y508_THEMA Uncharacterized protein TM_0508 OS=Thermotoga
maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC
100826 / MSB8) OX=243274 GN=TM_0508 PE=3 SV=1
Length=599
Score = 72.4 bits (176), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 50/136 (37%), Positives = 73/136 (54%), Gaps = 13/136 (10%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI +E A IVNAAN +LKHGGGVAGA+ +A +Q+ESD ++ G + G +
Sbjct 435 DITREEVDA----IVNAANEYLKHGGGVAGAIVRAGGSVIQEESDRIVQERGRVPTGEAV 490
Query 1082 LLSGHNL-AKKCLHVVGP---NLNAGEDIQLLKAAYEN-FNSQDILLA----PLLSAGIF 1132
+ S L AK +H VGP + GED L KA Y + ++ L P +S GIF
Sbjct 491 VTSAGKLKAKYVIHTVGPVWRGGSHGEDELLYKAVYNALLRAHELKLKSISMPAISTGIF 550
Query 1133 GAKPLQSLQVCVQTVR 1148
G +++ + + +R
Sbjct 551 GFPKERAVGIFSKAIR 566
>sp|Q4J9D2|Y1252_SULAC Uncharacterized protein Saci_1252 OS=Sulfolobus
acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929
/ NBRC 15157 / NCIMB 11770) OX=330779 GN=Saci_1252 PE=4
SV=1
Length=181
Score = 67.8 bits (164), Expect = 7e-11, Method: Composition-based stats.
Identities = 44/118 (37%), Positives = 62/118 (53%), Gaps = 10/118 (8%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI K A IVNAAN +L HGGGVA A+ ++ +Q+ESD+Y++ NGP+ VG
Sbjct 19 DITKVEADA----IVNAANSYLSHGGGVALAIVRSGGYIIQEESDEYVRRNGPVPVGEVA 74
Query 1082 LLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDIL-----LAPLLSAGIFG 1133
+ + L A+ +H VGP D +L A + D L P +S GI+G
Sbjct 75 VTTAGKLKARYVIHAVGPRYGIEGDDKLESAIRRSLEKADELKLSSIALPAISTGIYG 132
>sp|Q96XY5|Y2383_SULTO Uncharacterized protein STK_23830 OS=Sulfurisphaera
tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140
/ 7) OX=273063 GN=STK_23830 PE=4 SV=1
Length=182
Score = 62.4 bits (150), Expect = 4e-09, Method: Composition-based stats.
Identities = 41/106 (39%), Positives = 61/106 (58%), Gaps = 8/106 (8%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN +L+HGGGVA A+ + +QKES +Y++ GP+ GG + S L AK +
Sbjct 18 IVNAANSYLEHGGGVARAIVEKGGYIIQKESREYVRKYGPVPTGGVAVTSAGKLKAKYVI 77
Query 1094 HVVGPNLNAGEDIQLLKAAYENF--NSQDILLA----PLLSAGIFG 1133
H VGP E + L+ A N ++++ L+ P +S GI+G
Sbjct 78 HAVGPRYGI-EGEEKLEEAIRNALRKAEELKLSSIALPAISTGIYG 122
>sp|P0C6V7|R1AB_BEV Replicase polyprotein 1ab OS=Berne virus OX=11156
GN=rep PE=1 SV=1
Length=6857
Score = 65.5 bits (158), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 51/182 (28%), Positives = 85/182 (47%), Gaps = 13/182 (7%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQF----TGYLKLTDNVA 1017
L+ G+ E V V+ + +++ + E+ E + P E +F T + + D+
Sbjct 1641 LDIGSQCERVFVDYDVKKNEWTLSPEEGEDSDDNLDLPFEQYYEFKIGQTNVVLVQDDFK 1700
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ +K Q + +VN AN LKHGGG+A ++ +Q S++YI N + V
Sbjct 1701 -SVFEFLKSEQGVD--YVVNPANSQLKHGGGIAKVISCMCGPKLQAWSNNYITKNKTVPV 1757
Query 1078 GGSCLLSGHNLAKKC--LHVVGPNLNAGEDIQLLKAAYENF----NSQDILLAPLLSAGI 1131
+ G L KK +H VGP ++ G+ Q L A+ + Q +L +LS GI
Sbjct 1758 TKAIKSPGFQLGKKVNIIHAVGPRVSDGDVFQKLDQAWRSVFDLCEDQHTILTSMLSTGI 1817
Query 1132 FG 1133
FG
Sbjct 1818 FG 1819
>sp|P0C6F3|R1A_BEV Replicase polyprotein 1a OS=Berne virus OX=11156
GN=1a PE=1 SV=1
Length=4569
Score = 65.5 bits (158), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 51/182 (28%), Positives = 85/182 (47%), Gaps = 13/182 (7%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQF----TGYLKLTDNVA 1017
L+ G+ E V V+ + +++ + E+ E + P E +F T + + D+
Sbjct 1641 LDIGSQCERVFVDYDVKKNEWTLSPEEGEDSDDNLDLPFEQYYEFKIGQTNVVLVQDDFK 1700
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ +K Q + +VN AN LKHGGG+A ++ +Q S++YI N + V
Sbjct 1701 -SVFEFLKSEQGVD--YVVNPANSQLKHGGGIAKVISCMCGPKLQAWSNNYITKNKTVPV 1757
Query 1078 GGSCLLSGHNLAKKC--LHVVGPNLNAGEDIQLLKAAYENF----NSQDILLAPLLSAGI 1131
+ G L KK +H VGP ++ G+ Q L A+ + Q +L +LS GI
Sbjct 1758 TKAIKSPGFQLGKKVNIIHAVGPRVSDGDVFQKLDQAWRSVFDLCEDQHTILTSMLSTGI 1817
Query 1132 FG 1133
FG
Sbjct 1818 FG 1819
>sp|A7MG20|YMDB_CROS8 O-acetyl-ADP-ribose deacetylase OS=Cronobacter
sakazakii (strain ATCC BAA-894) OX=290339 GN=ymdB PE=3
SV=1
Length=180
Score = 59.3 bits (142), Expect = 5e-08, Method: Composition-based stats.
Identities = 49/156 (31%), Positives = 71/156 (46%), Gaps = 21/156 (13%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKC- 1092
VIVNAAN L GGGV GA+++A A+ + G G + + +LA K
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPALLAACRQVRQQQGECQPGHAVITEAGDLAAKAV 78
Query 1093 LHVVGPNLNAGED--IQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP G+D QLL AY N N + + P +S GI+G + Q+
Sbjct 79 VHTVGPVWRGGQDNEPQLLADAYRNSLQLVAANGYNSVAFPAISTGIYGYPKAAAAQIAF 138
Query 1145 QTVR---------TQVYIAVNDKA---LYEQVVMDY 1168
+TV QVY D+ LY++++ Y
Sbjct 139 ETVSDYLTRHPQPKQVYFVCYDEENFLLYQRLLGQY 174
>sp|B5F961|YMDB_SALA4 O-acetyl-ADP-ribose deacetylase OS=Salmonella
agona (strain SL483) OX=454166 GN=ymdB PE=3 SV=1
Length=179
Score = 58.5 bits (140), Expect = 1e-07, Method: Composition-based stats.
Identities = 52/157 (33%), Positives = 72/157 (46%), Gaps = 21/157 (13%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A A+ + G G + + L AK +
Sbjct 20 IVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA----------PLLSAGIFGAKPLQSLQ 1141
H VGP GE + +LL+AAY N +LLA P +S G++G Q+ +
Sbjct 80 HTVGPVWRGGEYQEAELLEAAYRNC----LLLAEANHFRSIAFPAISTGVYGYPRAQAAE 135
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
V V+TV + AL EQV D R+ A
Sbjct 136 VAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|P0C6V8|R1AB_BRV1 Replicase polyprotein 1ab OS=Breda virus
1 OX=360393 GN=rep PE=2 SV=1
Length=6733
Score = 62.8 bits (151), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 51/184 (28%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGY------LKLTDN 1015
L+ G+S E V V+ + ++ D +T ++ + E P NQ+ + + L +
Sbjct 1595 LDVGSSLEQVYVDYDVSKNVWDLSTH---LQDDSSDDLELPFNQYYEFKVGRASVVLVQD 1651
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
D +K Q + +VN AN LKHGGG+A ++ + S++YIK L
Sbjct 1652 DFKSVYDFLKSEQGVD--YVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYIKQYKKL 1709
Query 1076 TVGGSCLLSGHNLAK--KCLHVVGPNLNAGEDIQLLKAA----YENFNSQDILLAPLLSA 1129
V + G L K + +HVVGP + + L+A+ ++N +L +LS
Sbjct 1710 GVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVLTSMLST 1769
Query 1130 GIFG 1133
GIFG
Sbjct 1770 GIFG 1773
Score = 37.4 bits (85), Expect = 4.4, Method: Compositional matrix adjust.
Identities = 37/148 (25%), Positives = 69/148 (47%), Gaps = 16/148 (11%)
Query 3024 VVAGGIIAILVTCAAYYFMKFRRV-------FGEYNHVVAANALLFLMSFTILCLVPAYS 3076
+++ + +LV F+ R+ F + +VV LLF+ + +L +V
Sbjct 2937 IISPYVFVVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFK--LLFVNTVMVLFVVCLPP 2994
Query 3077 FLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNN 3136
+PGV V L+L + V FL +L ++F I+P++ ++V + W +
Sbjct 2995 LVPGVVFVLALWL----CDSVVFLLYLAVLSLF--ILPWFYVMLFVLIVGGFVFWWMMKS 3048
Query 3137 YLRKRVMFNGVTFS-TFEEAALCTFLLN 3163
+ +G+TF+ TFE+ + C F LN
Sbjct 3049 SDVVHLTPDGLTFNGTFEQVSKCVFPLN 3076
>sp|P0C6F4|R1A_BRV1 Replicase polyprotein 1a OS=Breda virus 1
OX=360393 GN=1a PE=3 SV=1
Length=4445
Score = 62.4 bits (150), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 51/184 (28%), Positives = 85/184 (46%), Gaps = 17/184 (9%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGY------LKLTDN 1015
L+ G+S E V V+ + ++ D +T ++ + E P NQ+ + + L +
Sbjct 1595 LDVGSSLEQVYVDYDVSKNVWDLSTH---LQDDSSDDLELPFNQYYEFKVGRASVVLVQD 1651
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
D +K Q + +VN AN LKHGGG+A ++ + S++YIK L
Sbjct 1652 DFKSVYDFLKSEQGVD--YVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYIKQYKKL 1709
Query 1076 TVGGSCLLSGHNLAK--KCLHVVGPNLNAGEDIQLLKAA----YENFNSQDILLAPLLSA 1129
V + G L K + +HVVGP + + L+A+ ++N +L +LS
Sbjct 1710 GVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVLTSMLST 1769
Query 1130 GIFG 1133
GIFG
Sbjct 1770 GIFG 1773
Score = 37.7 bits (86), Expect = 4.2, Method: Compositional matrix adjust.
Identities = 37/148 (25%), Positives = 69/148 (47%), Gaps = 16/148 (11%)
Query 3024 VVAGGIIAILVTCAAYYFMKFRRV-------FGEYNHVVAANALLFLMSFTILCLVPAYS 3076
+++ + +LV F+ R+ F + +VV LLF+ + +L +V
Sbjct 2937 IISPYVFVVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFK--LLFVNTVMVLFVVCLPP 2994
Query 3077 FLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNN 3136
+PGV V L+L + V FL +L ++F I+P++ ++V + W +
Sbjct 2995 LVPGVVFVLALWL----CDSVVFLLYLAVLSLF--ILPWFYVMLFVLIVGGFVFWWMMKS 3048
Query 3137 YLRKRVMFNGVTFS-TFEEAALCTFLLN 3163
+ +G+TF+ TFE+ + C F LN
Sbjct 3049 SDVVHLTPDGLTFNGTFEQVSKCVFPLN 3076
>sp|A8AI35|YMDB_CITK8 O-acetyl-ADP-ribose deacetylase OS=Citrobacter
koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
OX=290338 GN=ymdB PE=3 SV=1
Length=177
Score = 58.2 bits (139), Expect = 1e-07, Method: Composition-based stats.
Identities = 50/155 (32%), Positives = 75/155 (48%), Gaps = 25/155 (16%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A + + + G G + + L+G+ AK
Sbjct 19 VIVNAANASLLGGGGVDGAIHRAAGPTLLEACKKVRQQQGECPAGHAVITLAGNLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYENFNSQDILLA--------PLLSAGIFGAKPLQSLQV 1142
+H VGP G+ + QLL+ AY FNS ++LA P +S G +G + ++
Sbjct 79 IHTVGPVWRGGDHNESQLLEDAY--FNSLQLVLANGYRSVAFPAISTGAYGYPRPAAAEI 136
Query 1143 CVQTVR---------TQVYIAVNDKA---LYEQVV 1165
V TV QVY D+ LYE+++
Sbjct 137 AVNTVADFLARHALPEQVYFVCYDEETARLYERLL 171
>sp|P67341|YMDB_SALTY O-acetyl-ADP-ribose deacetylase OS=Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287
GN=ymdB PE=3 SV=1
Length=179
Score = 56.6 bits (135), Expect = 5e-07, Method: Composition-based stats.
Identities = 51/157 (32%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A A+ + G G + + L AK +
Sbjct 20 IVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA----------PLLSAGIFGAKPLQSLQ 1141
H VGP GE + +LL+ AY N +LLA P +S G++G Q+ +
Sbjct 80 HTVGPVWRGGEHQEAELLEEAYRNC----LLLAEANHFRSIAFPAISTGVYGYPRAQAAE 135
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
V V+TV + AL EQV D R+ A
Sbjct 136 VAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|P67342|YMDB_SALTI O-acetyl-ADP-ribose deacetylase OS=Salmonella
typhi OX=90370 GN=ymdB PE=3 SV=1
Length=179
Score = 56.6 bits (135), Expect = 5e-07, Method: Composition-based stats.
Identities = 51/157 (32%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A A+ + G G + + L AK +
Sbjct 20 IVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA----------PLLSAGIFGAKPLQSLQ 1141
H VGP GE + +LL+ AY N +LLA P +S G++G Q+ +
Sbjct 80 HTVGPVWRGGEHQEAELLEEAYRNC----LLLAEANHFRSIAFPAISTGVYGYPRAQAAE 135
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
V V+TV + AL EQV D R+ A
Sbjct 136 VAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|B4T2X8|YMDB_SALNS O-acetyl-ADP-ribose deacetylase OS=Salmonella
newport (strain SL254) OX=423368 GN=ymdB PE=3 SV=1
Length=179
Score = 55.8 bits (133), Expect = 7e-07, Method: Composition-based stats.
Identities = 50/157 (32%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A A+ + G G + + L AK +
Sbjct 20 IVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA----------PLLSAGIFGAKPLQSLQ 1141
H VGP GE + +LL+ AY N +LLA P +S G++G Q+ +
Sbjct 80 HTVGPVWRGGEHQEAELLEEAYRNC----LLLAEANHFRSIAFPAISTGVYGYPRAQAAE 135
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+ V+TV + AL EQV D R+ A
Sbjct 136 IAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|P0A8D6|YMDB_ECOLI O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli (strain K12) OX=83333 GN=ymdB PE=1 SV=1
Length=177
Score = 55.1 bits (131), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 48/140 (34%), Positives = 68/140 (49%), Gaps = 13/140 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ + G G + + L+G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL+ AY N NS + P +S G++G + ++ V
Sbjct 79 VHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAV 138
Query 1145 QTVRTQVYIAVNDKALYEQV 1164
+TV + AL EQV
Sbjct 139 KTVSE----FITRHALPEQV 154
>sp|P0A8D7|YMDB_ECOL6 O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310
GN=ymdB PE=3 SV=1
Length=177
Score = 55.1 bits (131), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 48/140 (34%), Positives = 68/140 (49%), Gaps = 13/140 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ + G G + + L+G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL+ AY N NS + P +S G++G + ++ V
Sbjct 79 VHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAV 138
Query 1145 QTVRTQVYIAVNDKALYEQV 1164
+TV + AL EQV
Sbjct 139 KTVSE----FITRHALPEQV 154
>sp|P0A8D8|YMDB_ECO57 O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli O157:H7 OX=83334 GN=ymdB PE=3 SV=1
Length=177
Score = 55.1 bits (131), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 48/140 (34%), Positives = 68/140 (49%), Gaps = 13/140 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ + G G + + L+G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL+ AY N NS + P +S G++G + ++ V
Sbjct 79 VHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAV 138
Query 1145 QTVRTQVYIAVNDKALYEQV 1164
+TV + AL EQV
Sbjct 139 KTVSE----FITRHALPEQV 154
>sp|C9Y0V8|YMDB_CROTZ O-acetyl-ADP-ribose deacetylase OS=Cronobacter
turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827
/ z3032) OX=693216 GN=ymdB PE=3 SV=1
Length=176
Score = 54.7 bits (130), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 48/156 (31%), Positives = 70/156 (45%), Gaps = 21/156 (13%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKC- 1092
VIVNAAN L GGGV GA+++A ++ + G G + + +LA K
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPSLLAACKVVRQQQGECQPGHAVITEAGDLAAKAV 78
Query 1093 LHVVGPNLNAGED--IQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP G D QLL AY N N + + P +S GI+G + Q+
Sbjct 79 IHTVGPIWRGGHDNEPQLLADAYRNSLELVTANGYNSVAFPAISTGIYGYPKAAAAQIAF 138
Query 1145 QTVR---------TQVYIAVNDKA---LYEQVVMDY 1168
+TV QVY D+ LY++++ Y
Sbjct 139 ETVSDYLTRRPQPKQVYFVCYDEENFLLYQRLLGQY 174
>sp|B5RBF3|YMDB_SALG2 O-acetyl-ADP-ribose deacetylase OS=Salmonella
gallinarum (strain 287/91 / NCTC 13346) OX=550538 GN=ymdB
PE=3 SV=1
Length=179
Score = 54.3 bits (129), Expect = 2e-06, Method: Composition-based stats.
Identities = 50/157 (32%), Positives = 71/157 (45%), Gaps = 21/157 (13%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A A+ + G G + + L AK +
Sbjct 20 IVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQQGECQTGHAVITPAGKLSAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA----------PLLSAGIFGAKPLQSLQ 1141
H VGP GE + +LL+ AY + +LLA P +S G++G Q+ +
Sbjct 80 HTVGPVWRGGEHQEAELLEEAYRSC----LLLAEANHFRSIAFPAISTGVYGYPRAQAAE 135
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
V V+TV + AL EQV D R+ A
Sbjct 136 VAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|D3RKJ0|YMDB_KLEVT O-acetyl-ADP-ribose deacetylase OS=Klebsiella
variicola (strain At-22) OX=640131 GN=ymdB PE=3 SV=1
Length=175
Score = 53.9 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 38/123 (31%), Positives = 63/123 (51%), Gaps = 9/123 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ ++ G G + + ++G A
Sbjct 19 VIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVITIAGDLPASAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP + G+ + Q L AY+N N+ + P +S G++G ++ ++ V
Sbjct 79 IHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYGYPKEEAAEIAV 138
Query 1145 QTV 1147
+TV
Sbjct 139 RTV 141
>sp|B5XXK9|YMDB_KLEP3 O-acetyl-ADP-ribose deacetylase OS=Klebsiella
pneumoniae (strain 342) OX=507522 GN=ymdB PE=3 SV=1
Length=175
Score = 53.9 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 38/123 (31%), Positives = 63/123 (51%), Gaps = 9/123 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ ++ G G + + ++G A
Sbjct 19 VIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVITIAGDLPASAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP + G+ + Q L AY+N N+ + P +S G++G ++ ++ V
Sbjct 79 IHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYGYPKEEAAEIAV 138
Query 1145 QTV 1147
+TV
Sbjct 139 RTV 141
>sp|Q0T5Z6|YMDB_SHIF8 O-acetyl-ADP-ribose deacetylase OS=Shigella
flexneri serotype 5b (strain 8401) OX=373384 GN=ymdB PE=3
SV=1
Length=177
Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 47/140 (34%), Positives = 67/140 (48%), Gaps = 13/140 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A A+ + G G + + L+G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL+ AY N NS + P +S G++ + ++ V
Sbjct 79 VHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYSYPRAAAAEIAV 138
Query 1145 QTVRTQVYIAVNDKALYEQV 1164
+TV + AL EQV
Sbjct 139 KTVSE----FITRHALPEQV 154
>sp|Q8CAS9|PARP9_MOUSE Protein mono-ADP-ribosyltransferase PARP9
OS=Mus musculus OX=10090 GN=Parp9 PE=1 SV=2
Length=866
Score = 55.8 bits (133), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 44/139 (32%), Positives = 65/139 (47%), Gaps = 16/139 (12%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKCL 1093
+VNAAN +L HG G+AG+L K +Q+ES I G ++VGG + L +
Sbjct 137 VVNAANENLLHGSGLAGSLVKTGGFEIQEESKRIIANVGKISVGGIAITGAGRLPCHLII 196
Query 1094 HVVGPNL---NAGEDIQLLKAAYENF----NSQDILLA----PLLSAGIFGAKPLQSLQV 1142
H VGP N+ I+LLK A N D+ + P LS+GIF L +
Sbjct 197 HAVGPRWTVTNSQTAIELLKFAIRNILDYVTKYDLRIKTVAIPALSSGIFQF----PLDL 252
Query 1143 CVQTVRTQVYIAVNDKALY 1161
C + + + DK ++
Sbjct 253 CTSIILETIRLYFQDKQMF 271
>sp|Q460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14
OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3
Length=1801
Score = 55.8 bits (133), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 41/125 (33%), Positives = 62/125 (50%), Gaps = 16/125 (13%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKC 1092
V+VNA+N LKH GG+A AL+KA +Q + D +K G L G + + L
Sbjct 818 VVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHV 877
Query 1093 LHVVGPNLNAGED---IQLLKAAY-------ENFNSQDILLAPLLSAGIFGAKPLQSLQV 1142
+H VGP + E + LL+ A E + + I + P +S+G+FG L
Sbjct 878 IHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAI-PAISSGVFGF----PLGR 932
Query 1143 CVQTV 1147
CV+T+
Sbjct 933 CVETI 937
>sp|A4W960|YMDB_ENT38 O-acetyl-ADP-ribose deacetylase OS=Enterobacter
sp. (strain 638) OX=399742 GN=ymdB PE=3 SV=1
Length=180
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/123 (32%), Positives = 59/123 (48%), Gaps = 9/123 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A + + + G G + + ++G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPQLLEACKTVRQQQGECAPGHAVITIAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + + L+ AY N N L P +S G++G + ++ V
Sbjct 79 IHAVGPVWQGGENHEARTLQDAYLNCLRLAAANGYKTLAFPAISTGVYGYPKAAAAEIAV 138
Query 1145 QTV 1147
TV
Sbjct 139 DTV 141
>sp|B7LT90|YMDB_ESCF3 O-acetyl-ADP-ribose deacetylase OS=Escherichia
fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766
/ IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128
/ CDC 0568-73) OX=585054 GN=ymdB PE=3 SV=2
Length=177
Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 40/123 (33%), Positives = 59/123 (48%), Gaps = 9/123 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
VIVNAAN L GGGV GA+++A + + + G G + + NL A+
Sbjct 19 VIVNAANSSLMGGGGVDGAIHRAAGPELLEACQKVRRQQGECPTGHAVITIAGNLPARAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL AY N N + P +S G++G + ++ V
Sbjct 79 IHTVGPVWRDGEHNEDQLLHDAYLNSLKLAQANGYKSIAFPAISTGVYGFPRAAAAEIAV 138
Query 1145 QTV 1147
+TV
Sbjct 139 KTV 141
>sp|P36327|POLN_EEVV3 Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain 3880) OX=36382 PE=3 SV=3
Length=2485
Score = 55.5 bits (132), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 52/145 (36%), Positives = 65/145 (45%), Gaps = 26/145 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A VI+NAAN + GGGV GAL K ES D P+ VG + L+ G
Sbjct 1342 TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL----QPIEVGKARLVKG--A 1390
Query 1089 AKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA----- 1134
AK +H VGPN N +I+ L AYE N N+ + PLLS GIF
Sbjct 1391 AKHIIHAVGPNFNKVSEIEGDKQLAEAYESIAKIVNDNNYKSVAIPLLSTGIFSGNKDRL 1450
Query 1135 -KPLQSLQVCVQTVRTQVYIAVNDK 1158
+ L L + T V I DK
Sbjct 1451 TQSLNHLLTALDTTDADVAIYCRDK 1475
>sp|D2TT52|YMDB_CITRI O-acetyl-ADP-ribose deacetylase OS=Citrobacter
rodentium (strain ICC168) OX=637910 GN=ymdB PE=3 SV=2
Length=177
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 13/124 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A + + + G G + + + L AK +
Sbjct 20 IVNAANPSLMGGGGVDGAIHRAAGPELLEACMTVRRQQGECPPGHAVITAAGRLPAKAVI 79
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDILLA--------PLLSAGIFGAKPLQSLQVC 1143
H VGP GE + QLL AY NS ++ LA P +S G++G + ++
Sbjct 80 HTVGPIWRGGEHNEAQLLHDAY--LNSLNLALANGYQSIAFPAISTGVYGYPRAAAAEIA 137
Query 1144 VQTV 1147
V T+
Sbjct 138 VNTI 141
>sp|Q32E73|YMDB_SHIDS O-acetyl-ADP-ribose deacetylase OS=Shigella
dysenteriae serotype 1 (strain Sd197) OX=300267 GN=ymdB
PE=3 SV=1
Length=177
Score = 51.6 bits (122), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 46/140 (33%), Positives = 66/140 (47%), Gaps = 13/140 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVN N L GGGV GA+++A A+ + G G + + L+G AK
Sbjct 19 VIVNVTNPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDCPTGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + QLL+ AY N NS + P +S G++G + ++ V
Sbjct 79 VHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPAISTGVYGYPRAAAAEIAV 138
Query 1145 QTVRTQVYIAVNDKALYEQV 1164
+TV + AL EQV
Sbjct 139 KTVSE----FITRHALPEQV 154
>sp|P27282|POLN_EEVVT Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain Trinidad donkey) OX=11038 PE=1 SV=3
Length=2493
Score = 55.1 bits (131), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 51/145 (35%), Positives = 65/145 (45%), Gaps = 26/145 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A VI+NAAN + GGGV GAL K ES D P+ VG + L+ G
Sbjct 1342 TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL----QPIEVGKARLVKG--A 1390
Query 1089 AKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA----- 1134
AK +H VGPN N +++ L AYE N N+ + PLLS GIF
Sbjct 1391 AKHIIHAVGPNFNKVSEVEGDKQLAEAYESIAKIVNDNNYKSVAIPLLSTGIFSGNKDRL 1450
Query 1135 -KPLQSLQVCVQTVRTQVYIAVNDK 1158
+ L L + T V I DK
Sbjct 1451 TQSLNHLLTALDTTDADVAIYCRDK 1475
>sp|Q8RHQ2|Y1951_FUSNN Uncharacterized protein FN1951 OS=Fusobacterium
nucleatum subsp. nucleatum (strain ATCC 25586 / DSM
15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG
13131 / VPI 4355) OX=190304 GN=FN1951 PE=4 SV=1
Length=175
Score = 51.6 bits (122), Expect = 2e-05, Method: Composition-based stats.
Identities = 38/107 (36%), Positives = 55/107 (51%), Gaps = 13/107 (12%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK-CL 1093
IVNAAN L+ GGGV GA+ KA + +E + G G + + G+NL K +
Sbjct 22 IVNAANSSLEMGGGVCGAIFKAAGSELAQECKEI----GGCNTGEAVITKGYNLPNKYII 77
Query 1094 HVVGPNLNAGEDIQ---LLKAAYENF---NSQDI--LLAPLLSAGIF 1132
H VGP + GE+ + L A YE+ N + I + P +S GI+
Sbjct 78 HTVGPRYSTGENREAERLASAYYESLKLANEKGIRRIAFPSISTGIY 124
>sp|P36328|POLN_EEVVP Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain P676) OX=36385 PE=1 SV=2
Length=2493
Score = 54.7 bits (130), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 51/145 (35%), Positives = 65/145 (45%), Gaps = 26/145 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A VI+NAAN + GGGV GAL K ES D P+ VG + L+ G
Sbjct 1342 TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL----QPIEVGKARLVKG--A 1390
Query 1089 AKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA----- 1134
AK +H VGPN N +++ L AYE N N+ + PLLS GIF
Sbjct 1391 AKHIIHAVGPNFNKVSEVEGDKQLAEAYESIAKIVNDNNYKSVAIPLLSTGIFSGNKDRL 1450
Query 1135 -KPLQSLQVCVQTVRTQVYIAVNDK 1158
+ L L + T V I DK
Sbjct 1451 TQSLNHLLTALDTTDADVAIYCRDK 1475
>sp|D5CE05|YMDB_ENTCC O-acetyl-ADP-ribose deacetylase OS=Enterobacter
cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054
/ NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56) OX=716541
GN=ymdB PE=3 SV=1
Length=180
Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 38/123 (31%), Positives = 59/123 (48%), Gaps = 9/123 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL-LSGHNLAKKC 1092
VIVNAAN L GGGV GA+++A + + + G G + + L+G AK
Sbjct 19 VIVNAANPSLMGGGGVDGAIHRAAGPQLLEACKTVRQQQGECPPGHAVITLAGDLPAKAV 78
Query 1093 LHVVGPNLNAGE--DIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP + G+ + +L+ AY N N + P +S G++G + + V
Sbjct 79 IHAVGPIWHGGDRHEASILEEAYRNCLRLAADNGYKTMAFPAISTGVYGYPKAAAATIAV 138
Query 1145 QTV 1147
TV
Sbjct 139 DTV 141
>sp|Q87JZ5|Y4103_VIBPA Macro domain-containing protein VPA0103
OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
OX=223926 GN=VPA0103 PE=4 SV=1
Length=170
Score = 48.5 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 42/141 (30%), Positives = 71/141 (50%), Gaps = 17/141 (12%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKES---DDYIKLNGPLTVGGSCLLSG 1085
+A+ IVNAAN + GGGV GA+++A A+ DD + P G + +
Sbjct 13 TAHVDAIVNAANPRMLGGGGVDGAIHRAAGPALINACYAVDDVDGIRCPF--GDARITEA 70
Query 1086 HNL-AKKCLHVVGPNLNAGEDIQ-LLKAAYENFNSQDILLA--------PLLSAGIFGAK 1135
NL A+ +H VGP + D + +L++AY+ S D+ LA P +S G++G
Sbjct 71 GNLNARYVIHAVGPIYDKFADPKTVLESAYQ--RSLDLALANHCQSVALPAISCGVYGYP 128
Query 1136 PLQSLQVCVQTVRTQVYIAVN 1156
P ++ +V + + Y A++
Sbjct 129 PQEAAEVAMAVCQRPEYAALD 149
>sp|Q8IXQ6|PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9
OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2
Length=854
Score = 51.6 bits (122), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 47/160 (29%), Positives = 76/160 (48%), Gaps = 19/160 (12%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKCL 1093
+VNAAN L HGGG+A AL KA +Q+ES ++ G ++ G + L K+ +
Sbjct 135 VVNAANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEIAVTGAGRLPCKQII 194
Query 1094 HVVGPNL----NAGEDIQLLKA--------AYENFNSQDILLAPLLSAGIFGAKPLQSLQ 1141
H VGP G +L +A Y+N + + + + P LS+GIF L
Sbjct 195 HAVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIKTVAI-PALSSGIFQF----PLN 249
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYL-DNLKPRVEAPK 1180
+C +T+ + +++ K + + +L N P V A K
Sbjct 250 LCTKTIVETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFK 289
>sp|Q8V294|POLN_EEVVC Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain CPA201) OX=376610 PE=3 SV=3
Length=2497
Score = 51.6 bits (122), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 49/145 (34%), Positives = 65/145 (45%), Gaps = 26/145 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A VIVNAAN + G GV GAL + ES D P+ VG + L+ G+
Sbjct 1342 TATEGVIVNAANSKGQPGSGVCGALYRK-----YPESFDL----QPIEVGKARLVKGN-- 1390
Query 1089 AKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA----- 1134
+K +H VGPN N +++ L AYE N N+ + PLLS GIF
Sbjct 1391 SKHLIHAVGPNFNKVSEVEGDKQLAEAYESIARIINDNNYRSVAIPLLSTGIFAGNKDRL 1450
Query 1135 -KPLQSLQVCVQTVRTQVYIAVNDK 1158
+ L L + T V I DK
Sbjct 1451 MQSLNHLLTALDTTDADVAIYCRDK 1475
>sp|Q8RB30|Y995_CALS4 Macro domain-containing protein TTE0995
OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain
DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=TTE0995
PE=4 SV=1
Length=175
Score = 47.8 bits (112), Expect = 5e-04, Method: Composition-based stats.
Identities = 42/124 (34%), Positives = 61/124 (49%), Gaps = 13/124 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA++KA A+ +E + G G + + NL AK +
Sbjct 20 IVNAANSSLIGGGGVDGAIHKAGGPAIAEELKVIREKQGGCPTGHAVITGAGNLKAKYVI 79
Query 1094 HVVGP----------NLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVC 1143
H VGP NL A I+ LK A E +N + I P +S G +G ++ ++
Sbjct 80 HAVGPIWKGGNHNEDNLLASAYIESLKLADE-YNVKTIAF-PSISTGAYGFPVERAARIA 137
Query 1144 VQTV 1147
++ V
Sbjct 138 LRVV 141
>sp|Q2EMV9|PAR14_MOUSE Protein mono-ADP-ribosyltransferase PARP14
OS=Mus musculus OX=10090 GN=Parp14 PE=1 SV=3
Length=1817
Score = 50.4 bits (119), Expect = 5e-04, Method: Compositional matrix adjust.
Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 17/137 (12%)
Query 1023 IVKEAQSANPM-VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
+++E S P+ V+VNAAN +LKH G+A AL+KA +Q E D +K G + G +
Sbjct 817 VLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAV 876
Query 1082 LLSGHNLA-KKCLHVVGPNLNAG---EDIQLLKAAY-------ENFNSQDILLAPLLSAG 1130
+ L +H VGP E + LLK E + I + P +SAG
Sbjct 877 ISKAGKLPCHHVIHAVGPRWKGDKVLECVSLLKKVVRQSLSLAEEHRCRSIAM-PAVSAG 935
Query 1131 IFGAKPLQSLQVCVQTV 1147
IF L++CV +
Sbjct 936 IFDF----PLELCVANI 948
>sp|Q8KAE4|Y2219_CHLTE Macro domain-containing protein CT2219
OS=Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC
103806 / TLS) OX=194439 GN=CT2219 PE=4 SV=1
Length=172
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 46/146 (32%), Positives = 69/146 (47%), Gaps = 15/146 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ DNV I + + S IVNAAN L GGGV GA+++A + + + L
Sbjct 1 MPDNVLIHAIK--ADITSLTVDAIVNAANTSLLGGGGVDGAIHRAAGPKLLEACRE---L 55
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENFNSQDI------L 1122
G LT G + + G+ L A +H VGP + G + +LL + Y N I +
Sbjct 56 GGCLT-GEAKITKGYRLPATFVIHTVGPVWHGGNHGEAELLASCYRNSLKLAIEHHCRTI 114
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVR 1148
P +S GI+G Q+ + + TVR
Sbjct 115 AFPSISTGIYGYPVEQAAAIAITTVR 140
>sp|Q8Y2K1|Y334_RALN1 Macro domain-containing protein RSc0334
OS=Ralstonia nicotianae (strain GMI1000) OX=267608 GN=RSc0334
PE=4 SV=1
Length=171
Score = 46.2 bits (108), Expect = 0.001, Method: Composition-based stats.
Identities = 41/123 (33%), Positives = 61/123 (50%), Gaps = 13/123 (11%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A + + L+G T G + + G L A+ +
Sbjct 23 IVNAANSALLGGGGVDGAIHRAAGPELLEACR---ALHGCRT-GQAKITPGFLLPARYII 78
Query 1094 HVVGPNLNAG--EDIQLLKAAYEN----FNSQDI--LLAPLLSAGIFGAKPLQSLQVCVQ 1145
H VGP G ++ LL A Y N D+ + P +S G++G P + + V+
Sbjct 79 HTVGPIWRGGRQDEAALLAACYRNSLALAKQHDVRTIAFPCISTGVYGFPPQLAAPIAVR 138
Query 1146 TVR 1148
TVR
Sbjct 139 TVR 141
>sp|Q8EYT0|Y4133_LEPIN Macro domain-containing protein LA_4133
OS=Leptospira interrogans serogroup Icterohaemorrhagiae serovar
Lai (strain 56601) OX=189518 GN=LA_4133 PE=4 SV=1
Length=175
Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 40/123 (33%), Positives = 63/123 (51%), Gaps = 11/123 (9%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A + +E + G VG + + + L AK +
Sbjct 20 IVNAANSSLLGGGGVDGAIHRAGGPEILEECYKIREKQGECKVGEAVITTAGRLNAKFII 79
Query 1094 HVVGPNLNAG---EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
H VGP + G ED +LL AY+N +S + P +S GI+ ++ ++ +
Sbjct 80 HTVGPIWSGGNKNED-ELLSNAYKNSLLLAKNHSLKTIAFPNISTGIYHFPKERAAKIAI 138
Query 1145 QTV 1147
Q+V
Sbjct 139 QSV 141
>sp|Q9WJC7|POLN_EEVVM Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain Mena II) OX=36384 PE=3 SV=3
Length=2499
Score = 48.9 bits (115), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 48/145 (33%), Positives = 64/145 (44%), Gaps = 26/145 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A VIVNAAN + G GV GAL + ES D P+ VG + L+ G
Sbjct 1342 TATEGVIVNAANSKGQPGSGVCGALYRK-----YPESFDL----QPIEVGKARLVKGS-- 1390
Query 1089 AKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA----- 1134
+K +H VGPN + +++ L AYE N N+ + PLLS GIF
Sbjct 1391 SKHIIHAVGPNFSKVSEVEGDKQLAEAYESIAKIINDNNYRSVAIPLLSTGIFAGNKDRL 1450
Query 1135 -KPLQSLQVCVQTVRTQVYIAVNDK 1158
+ L L + T V I DK
Sbjct 1451 MQSLNHLLTALDTTDADVAIYCRDK 1475
>sp|Q72M93|Y3295_LEPIC Macro domain-containing protein LIC_13295
OS=Leptospira interrogans serogroup Icterohaemorrhagiae serovar
copenhageni (strain Fiocruz L1-130) OX=267671 GN=LIC_13295
PE=4 SV=1
Length=175
Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 40/123 (33%), Positives = 63/123 (51%), Gaps = 11/123 (9%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A + +E + G VG + + + L AK +
Sbjct 20 IVNAANSSLLGGGGVDGAIHRAGGPEILEECYKIREKQGECKVGEAVITTAGRLNAKFII 79
Query 1094 HVVGPNLNAG---EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCV 1144
H VGP + G ED +LL AY+N +S + P +S GI+ ++ ++ +
Sbjct 80 HTVGPIWSGGNKNED-ELLSNAYKNSLLLAKNHSLKTIAFPNISTGIYHFPKERAAKIAI 138
Query 1145 QTV 1147
Q+V
Sbjct 139 QSV 141
>sp|Q93SX7|Y189_ACISE Macro domain-containing protein OS=Acinetobacter
sp. (strain ED45-25) OX=194927 PE=4 SV=1
Length=183
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 38/126 (30%), Positives = 64/126 (51%), Gaps = 9/126 (7%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVN+AN L GGG+ ++K M++E + G G + + + NL AK +
Sbjct 19 IVNSANKSLLGGGGLDYVIHKKAGPLMKEECVRLNQEKGGCPTGQAEVTTAGNLPAKYLI 78
Query 1094 HVVGPNLNAGE--DIQLLKAAYEN--FNSQDI----LLAPLLSAGIFGAKPLQSLQVCVQ 1145
H VGP GE + QLL AY N F + +I + P +S G++G P ++ ++ +
Sbjct 79 HAVGPRWLDGEHNEPQLLCDAYSNALFKANEIHALTVSFPCISTGVYGFPPQKAAEIAIG 138
Query 1146 TVRTQV 1151
T+ + +
Sbjct 139 TILSML 144
>sp|E1SDF1|YMDB1_PANVC O-acetyl-ADP-ribose deacetylase 1 OS=Pantoea
vagans (strain C9-1) OX=712898 GN=ymdB1 PE=3 SV=1
Length=171
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 13/136 (10%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI K + A IVNAAN L GGGV GA+++A + E G VG +
Sbjct 10 DITKVSAEA----IVNAANSSLLGGGGVDGAIHRAGGPVILAECQLIRNRQGGCKVGDAV 65
Query 1082 LLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYE------NFNSQDILLAPLLSAGIF 1132
+ NL A +H VGP + G ++ LLK AY+ +++ + P +S GI+
Sbjct 66 ITGAGNLPADYVIHTVGPRWSDGRHDEDALLKRAYQSCFKLVDYHGIKTVSFPNISTGIY 125
Query 1133 GAKPLQSLQVCVQTVR 1148
G ++ + + ++
Sbjct 126 GFPKERAATIALDVIK 141
>sp|Q8Q0F9|Y177_METMA Macro domain-containing protein MM_0177
OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1
/ Go1 / JCM 11833 / OCM 88) OX=192952 GN=MM_0177 PE=4 SV=1
Length=187
Score = 45.1 bits (105), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 49/145 (34%), Positives = 71/145 (49%), Gaps = 19/145 (13%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
D + I DIVK A IVNAAN L GGGV GA+++A A+ +E LNG
Sbjct 19 DRIRIFEGDIVKMRVDA----IVNAANNTLLGGGGVDGAIHRAAGPALLEECKT---LNG 71
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAY-------ENFNSQDILL 1123
T G + + SG+ L AK +H VGP GE + +LL + Y ++ + I
Sbjct 72 CPT-GEAKITSGYLLPAKYIIHTVGPVWQGGEKGEDELLASCYRKSLELARDYKIKTIAF 130
Query 1124 APLLSAGIFGAKPLQSLQVCVQTVR 1148
P +S G +G ++ + V V+
Sbjct 131 -PAISTGAYGFPSERAAGIAVSQVK 154
>sp|Q7MTZ7|MACRO_PORGI Macro domain-containing protein PG1779
OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619
GN=PG_1779 PE=2 SV=1
Length=164
Score = 43.1 bits (100), Expect = 0.014, Method: Compositional matrix adjust.
Identities = 39/122 (32%), Positives = 63/122 (52%), Gaps = 13/122 (11%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV GA+++A + +E LNG T G S + G+NL A+ +
Sbjct 19 IVNAANHTLLGGGGVDGAIHRAAGPELLEECR---TLNGCPT-GESKITGGYNLPAQYVI 74
Query 1094 HVVGPNLNAGE--DIQLLKAAYENFNSQDI------LLAPLLSAGIFGAKPLQSLQVCVQ 1145
H VGP + G+ + +LL + Y S + + P +S G++ Q+ ++ +
Sbjct 75 HTVGPVWHGGQHGEPELLASCYRTSLSIALDKGLKSIAFPCISTGVYRYPKDQAARIALA 134
Query 1146 TV 1147
T+
Sbjct 135 TI 136
>sp|Q9ZBG3|Y6450_STRCO Macro domain-containing protein SCO6450
OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
OX=100226 GN=SCO6450 PE=4 SV=1
Length=169
Score = 43.1 bits (100), Expect = 0.015, Method: Composition-based stats.
Identities = 44/138 (32%), Positives = 67/138 (49%), Gaps = 14/138 (10%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI--KLNGPLTVGG 1079
DI +++ A IVNAAN L GGGV GA+++ A+ E L L G
Sbjct 10 DITRQSADA----IVNAANSSLLGGGGVDGAIHRRGGPAILAECRRLRAGHLGKGLPTGR 65
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-LLKAAY-ENFNSQDILLA-----PLLSAGI 1131
+ + +L A+ +H VGP +A ED LL + Y E+ + D L A P +S G+
Sbjct 66 AVATTAGDLDARWVIHTVGPVWSATEDRSGLLASCYRESLRTADELGARTVAFPAISTGV 125
Query 1132 FGAKPLQSLQVCVQTVRT 1149
+ + ++ V+TV T
Sbjct 126 YRWPMDDAARIAVETVAT 143
>sp|Q88SK6|Y3408_LACPL Macro domain-containing protein lp_3408
OS=Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB
8826 / WCFS1) OX=220668 GN=lp_3408 PE=4 SV=1
Length=172
Score = 42.7 bits (99), Expect = 0.020, Method: Composition-based stats.
Identities = 53/165 (32%), Positives = 76/165 (46%), Gaps = 30/165 (18%)
Query 1016 VAIKCV--DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
V IK + DI K A IVNAAN L GGGV GA+++A A+ L+G
Sbjct 2 VEIKVIHGDITKMTVDA----IVNAANTSLLGGGGVDGAIHRAAGPALLAACR---PLHG 54
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENF------NSQDILLA 1124
T G + + G L AK +H GP G+ ++QLL +Y N N +
Sbjct 55 CAT-GEAKITPGFRLPAKYVIHTPGPVWQGGQHNELQLLANSYRNSLNLAAENHCQTVAF 113
Query 1125 PLLSAGIFG-----AKP--LQSLQVCVQ----TVRTQVYIAVNDK 1158
P +S G++ A P L++LQ Q TV+T + +D+
Sbjct 114 PSISTGVYHFPLSIAAPLALKTLQATAQTTAHTVQTITIVCFDDQ 158
>sp|P13896|POLN_WEEV Polyprotein P1234 OS=Western equine encephalitis
virus OX=11039 PE=3 SV=3
Length=2467
Score = 45.1 bits (105), Expect = 0.021, Method: Compositional matrix adjust.
Identities = 53/176 (30%), Positives = 77/176 (44%), Gaps = 39/176 (22%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI K A A IVNAAN + G GV GAL + A ++ P+ VG +
Sbjct 1337 DISKSADQA----IVNAANSKGQPGSGVCGALYRKWPAAFDRQ---------PIAVGTAR 1383
Query 1082 LLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENF----NSQDI--LLAPLLSAGIF 1132
L+ L +H VGPN + + + L AAY + N++ I + PLLS GI+
Sbjct 1384 LVKHEPL---IIHAVGPNFSKMPEPEGDLKLAAAYMSIASIVNAERITKISVPLLSTGIY 1440
Query 1133 GA---KPLQSLQ---VCVQTVRTQVYIAVNDK--------ALYEQVVMDYLDNLKP 1174
+ +QSL T V I DK A++ + ++ LD+ KP
Sbjct 1441 SGGKDRVMQSLHHLFTAFDTTDADVTIYCLDKQWETRIIEAIHRKESVEILDDDKP 1496
>sp|O28751|Y1521_ARCFU ADP-ribose glycohydrolase AF_1521 OS=Archaeoglobus
fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628
/ NBRC 100126 / VC-16) OX=224325 GN=AF_1521 PE=1 SV=2
Length=192
Score = 43.1 bits (100), Expect = 0.022, Method: Composition-based stats.
Identities = 44/147 (30%), Positives = 71/147 (48%), Gaps = 23/147 (16%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNG-----------AMQKE-SDDYIKLNGPLTVGGSCL 1082
IVNAAN L+HGGGVA A+ KA G AM+++ DYI +G + V +
Sbjct 29 IVNAANKRLEHGGGVAYAIAKACAGDAGLYTEISKKAMREQFGRDYID-HGEVVVTPAMN 87
Query 1083 LSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF-----NSQDI----LLAPLLSAGIFG 1133
L + K H VGP + +L + Y+ F ++++ + P +SAGI+G
Sbjct 88 LEERGI-KYVFHTVGPICSGMWSEELKEKLYKAFLGPLEKAEEMGVESIAFPAVSAGIYG 146
Query 1134 AKPLQSLQVCVQTVRTQVYIAVNDKAL 1160
+ ++ ++ V+ AV + AL
Sbjct 147 CDLEKVVETFLEAVKNFKGSAVKEVAL 173
>sp|Q4QXJ8|POLN_EEEVF Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain Florida 91-469) OX=374598 PE=1 SV=3
Length=2494
Score = 44.3 bits (103), Expect = 0.036, Method: Compositional matrix adjust.
Identities = 45/134 (34%), Positives = 58/134 (43%), Gaps = 34/134 (25%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI K +N VIVNAAN + G GV GAL + GA K+ P+ G +
Sbjct 1337 DITK----SNDEVIVNAANNKGQPGSGVCGALYRKWPGAFDKQ---------PVATGKAH 1383
Query 1082 LLSGHNLAKKCLHVVGPN---LNAGEDIQLLKAAY---------ENFNSQDILLAPLLSA 1129
L+ + +H VGPN L+ E Q L Y E F I PLLS
Sbjct 1384 LVKH---SPNVIHAVGPNFSRLSENEGDQKLSEVYMDIARIINNERFTKVSI---PLLST 1437
Query 1130 GIFGA---KPLQSL 1140
GI+ + +QSL
Sbjct 1438 GIYAGGKDRVMQSL 1451
>sp|O59182|Y1513_PYRHO Uncharacterized protein PH1513 OS=Pyrococcus
horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974
/ NBRC 100139 / OT-3) OX=70601 GN=PH1513 PE=4 SV=1
Length=190
Score = 42.0 bits (97), Expect = 0.041, Method: Composition-based stats.
Identities = 46/150 (31%), Positives = 74/150 (49%), Gaps = 27/150 (18%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNG-----------AMQKE-SDDYIKLNGPLTVGGSCL 1082
IVNAAN +L+HGGGVA A+ KA +G M+++ D+I+ +G + V
Sbjct 20 IVNAANKYLEHGGGVAYAIAKAASGDVSEYTRISKEEMRRQLGKDWIE-HGEVVVTPPMK 78
Query 1083 LSGHNLAKKCLHVVGP------NLNAGEDIQL-----LKAAYENFNSQDILLAPLLSAGI 1131
L N K +H VGP + + E ++L LK A E + I P +SAGI
Sbjct 79 LK-ENGVKYVIHTVGPYCGGVWSKDKEEKLKLAILGALKKADE-LGVKSIAF-PAISAGI 135
Query 1132 FGAKPLQSLQVCVQTVRTQVYIAVNDKALY 1161
+G + ++ + V+ + +A + K +Y
Sbjct 136 YGCPLKEVVRTFKEVVKEFLKVANHVKEVY 165
>sp|Q71W03|Y2748_LISMF Macro domain-containing protein LMOf2365_2748
OS=Listeria monocytogenes serotype 4b (strain F2365)
OX=265669 GN=LMOf2365_2748 PE=4 SV=1
Length=176
Score = 41.2 bits (95), Expect = 0.073, Method: Compositional matrix adjust.
Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 9/124 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
VIVNAAN L GGGV GA+++A + KE + I G G + + S +L A
Sbjct 17 VIVNAANPGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGTCPAGEAVITSAGDLQASYI 76
Query 1093 LHVVGPNLNAGEDIQLLKAAYENFNSQDI--------LLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + K A + + D+ + P +S G++G + +V +
Sbjct 77 IHAVGPIWKDGEHQEANKLASCYWKALDLAAGKELTSIAFPNISTGVYGFPKKLAAEVAL 136
Query 1145 QTVR 1148
TVR
Sbjct 137 YTVR 140
>sp|Q8Y3S3|Y2759_LISMO Macro domain-containing protein lmo2759
OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679
/ EGD-e) OX=169963 GN=lmo2759 PE=4 SV=1
Length=176
Score = 41.2 bits (95), Expect = 0.080, Method: Compositional matrix adjust.
Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 9/124 (7%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
VIVNAAN L GGGV GA+++A + KE + I G G + + S +L A
Sbjct 17 VIVNAANSGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGSCPAGEAVITSAGDLKATYI 76
Query 1093 LHVVGPNLNAGEDIQLLKAAYENFNSQDI--------LLAPLLSAGIFGAKPLQSLQVCV 1144
+H VGP GE + K A + + D+ + P +S G++G + +V +
Sbjct 77 IHAVGPIWKDGEHQEANKLASCYWKALDLAAGKDLTSIAFPNISTGVYGFPKKLAAEVAL 136
Query 1145 QTVR 1148
TVR
Sbjct 137 YTVR 140
>sp|P05720|YCX1_AUXPY Uncharacterized 12.7 kDa protein in 16S-23S
DNA spacer OS=Auxenochlorella pyrenoidosa OX=3078 PE=4 SV=1
Length=110
Score = 39.7 bits (91), Expect = 0.083, Method: Composition-based stats.
Identities = 26/68 (38%), Positives = 40/68 (59%), Gaps = 5/68 (7%)
Query 492 KSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFART 551
+SL K+F ++E NYKV K K + + Q +SVL + SQ + +I +I+++
Sbjct 47 ESLTNKNFSKLIEFLDNYKVEKAKSI----TLQQLQSVLQNIKLNNSQKSEIIENIYSK- 101
Query 552 LDAANHSI 559
LDAANH I
Sbjct 102 LDAANHLI 109
>sp|Q306W6|POLN_EEEV1 Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain PE-0.0155) OX=374596 PE=1 SV=3
Length=2471
Score = 43.1 bits (100), Expect = 0.088, Method: Compositional matrix adjust.
Identities = 52/187 (28%), Positives = 78/187 (42%), Gaps = 35/187 (19%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL 1093
VIVNAAN + G GV GAL K GA K P+ G + L+ +
Sbjct 1345 VIVNAANNKGQPGAGVCGALYKKWPGAFDK---------APIATGTAHLVKH---TPNII 1392
Query 1094 HVVGPNLNAGEDI---QLLKAAY---------ENFNSQDILLAPLLSAGIFGA---KPLQ 1138
H VGPN + ++ Q L Y E +N I PLLS G++ + +Q
Sbjct 1393 HAVGPNFSRMSEVEGNQKLSEVYMDIAKIINKERYNKVSI---PLLSTGVYAGGKDRVMQ 1449
Query 1139 SLQ---VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTE-E 1194
SL + T V I DK +E + D + + E + ++P + E + +
Sbjct 1450 SLNHLFTAMDTTDADVTIYCLDKQ-WETRIKDAIARKESVEELVEDDKPVDIELVRVHPQ 1508
Query 1195 KSVVQKP 1201
S+V +P
Sbjct 1509 SSLVGRP 1515
>sp|Q926Y8|Y2902_LISIN Macro domain-containing protein lin2902
OS=Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP
11262) OX=272626 GN=lin2902 PE=4 SV=1
Length=176
Score = 40.8 bits (94), Expect = 0.093, Method: Compositional matrix adjust.
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-A 1089
N VIVNAAN L GGGV GA+++A + KE + I G G + + S +L A
Sbjct 14 NVDVIVNAANPGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGSCPAGEAVITSAGDLKA 73
Query 1090 KKCLHVVGPNLNAGEDIQLLKAAYENFNSQDI--------LLAPLLSAGIFGAKPLQSLQ 1141
+H VGP GE + K A + + D+ + P +S G++G + +
Sbjct 74 HFIIHAVGPIWKDGEHQEANKLASCYWKALDLAAGKDLTSIAFPNISTGVYGFPKKLAAE 133
Query 1142 VCVQTVR 1148
V + TVR
Sbjct 134 VALYTVR 140
>sp|Q9V0Y3|Y656_PYRAB Uncharacterized protein PYRAB06560 OS=Pyrococcus
abyssi (strain GE5 / Orsay) OX=272844 GN=PYRAB06560
PE=4 SV=2
Length=183
Score = 40.8 bits (94), Expect = 0.10, Method: Composition-based stats.
Identities = 44/129 (34%), Positives = 62/129 (48%), Gaps = 28/129 (22%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNG-----------AMQKE-SDDYIKLNGPLTVGGSCL 1082
IVNAAN +L+HGGGVA A+ KA +G M+K+ D+I+ +G + V
Sbjct 17 IVNAANKYLEHGGGVAYAIAKAASGDVSEYIRISKEEMRKQIGRDWIE-HGEVVVTPPLN 75
Query 1083 LSGHNLAKKCLHVVGPNLNAGED-----------IQLLKAAYENFNSQDILLAPLLSAGI 1131
L+ N K +H VGP D + LK A E + I P +SAGI
Sbjct 76 LA-KNGVKYVIHTVGPYCGGKWDEDKRKKLELAILGALKKADE-LGVRSIAF-PAISAGI 132
Query 1132 FGAKPLQSL 1140
+G PL+ +
Sbjct 133 YGC-PLEEV 140
>sp|O40955|POLN_RUBVR Non-structural polyprotein p200 OS=Rubella
virus (strain RA27/3 vaccine) OX=11044 PE=1 SV=1
Length=2116
Score = 42.7 bits (99), Expect = 0.12, Method: Compositional matrix adjust.
Identities = 51/213 (24%), Positives = 80/213 (38%), Gaps = 32/213 (15%)
Query 1009 YLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY 1068
Y + V ++ DI+ V+VNAAN L G GV GA+ A+ +
Sbjct 812 YARAAGPVHLRVRDIMDPPPGCK--VVVNAANEGLLAGSGVCGAIFANATAALAAD---- 865
Query 1069 IKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPN-------LNAGEDIQLLKAAYENFNSQD 1120
+ P G + GH +H V P L GE LL+ AY + +
Sbjct 866 CRRLAPCPTGEAVATPGHGCGYTHIIHAVAPRRPRDPAALEEGE--ALLERAYRSIVALA 923
Query 1121 ILLA------PLLSAGIFGAKPLQSLQVCVQTVRTQ------VYIAVNDKALYEQVVMDY 1168
PLL AG++G +SL+ + RT+ ++I D+A +
Sbjct 924 AARRWARVACPLLGAGVYGWSAAESLRAALAATRTEPAERVSLHICHPDRATLTHASVLV 983
Query 1169 LDNLKPRVEAPKQEEP----PNTEDSKTEEKSV 1197
L R +P EP P + + ++S
Sbjct 984 GAGLAARRVSPPPTEPLASCPAGDPGRPAQRSA 1016
>sp|Q9UTG3|YKEE_SCHPO Uncharacterized protein C1805.14 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC1805.14
PE=4 SV=1
Length=452
Score = 42.0 bits (97), Expect = 0.12, Method: Composition-based stats.
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 3/83 (4%)
Query 912 AGEENFSS-RMYCSFYPPDEEEEDDAECEEEEID--ETCEHEYGTEDDYQGLPLEFGASA 968
AGEE F + D + + D E E E+D + EH++G EDD+ G +
Sbjct 97 AGEETFGQIERFEYLLSSDGDGDGDVEIENPEVDDYQVSEHDFGLEDDFNGDGCQQMIEI 156
Query 969 ETVRVEEEEEEDWLDDTTEQSEI 991
E+ EEEED ++ +S++
Sbjct 157 ESDEAISEEEEDLSNENKSESQL 179
>sp|Q8BCR0|POLN_RUBVN Non-structural polyprotein p200 OS=Rubella
virus (strain RN-UK86) OX=376267 PE=3 SV=1
Length=2116
Score = 42.4 bits (98), Expect = 0.13, Method: Compositional matrix adjust.
Identities = 49/196 (25%), Positives = 74/196 (38%), Gaps = 28/196 (14%)
Query 1009 YLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY 1068
Y + V ++ DI+ V+VNAAN L G GV GA+ A+ +
Sbjct 812 YARAAGPVHLRVRDIMDPPPGCK--VVVNAANEGLLAGSGVCGAIFANATAALAAD---- 865
Query 1069 IKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPN-------LNAGEDIQLLKAAYENF---- 1116
+ P G + GH +H V P L GE LL+ AY +
Sbjct 866 CRRLAPCPTGEAVATPGHGCGYTHIIHAVAPRRPRDPAALEEGE--ALLERAYRSIVALA 923
Query 1117 --NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQ------VYIAVNDKALYEQVVMDY 1168
+ PLL AG++G +SL+ + RT+ ++I D+A +
Sbjct 924 AARRWACVACPLLGAGVYGWSAAESLRAALAATRTEPAERVSLHICHPDRATLTHASVLV 983
Query 1169 LDNLKPRVEAPKQEEP 1184
L R +P EP
Sbjct 984 GAGLAARRVSPPPTEP 999
>sp|Q8TQD0|Y1614_METAC Macro domain-containing protein MA_1614
OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834
/ JCM 12185 / C2A) OX=188937 GN=MA_1614 PE=4 SV=1
Length=195
Score = 40.0 bits (92), Expect = 0.20, Method: Compositional matrix adjust.
Identities = 42/135 (31%), Positives = 66/135 (49%), Gaps = 19/135 (14%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
IVNAAN L GGGV GA+++A + +E LNG T G + + G+ L AK
Sbjct 43 AIVNAANNTLLGGGGVDGAIHRAAGPGLLEECRT---LNGCPT-GEAKITKGYLLPAKYV 98
Query 1093 LHVVGP---NLNAGEDIQLLKAAY-------ENFNSQDILLAPLLSAGIFGAKPLQSLQV 1142
+H VGP GED + L + Y ++ + I P +S G +G ++ ++
Sbjct 99 IHTVGPIWQEGTKGED-EFLASCYRKSLELARKYDVKTIAF-PTISTGAYGFPSERAARI 156
Query 1143 CVQTVRTQVYIAVND 1157
V V+ ++ VN+
Sbjct 157 AVSQVKE--FLKVNE 169
>sp|P13889|POLN_RUBVT Non-structural polyprotein p200 OS=Rubella
virus (strain Therien) OX=11045 PE=3 SV=5
Length=2116
Score = 41.6 bits (96), Expect = 0.23, Method: Compositional matrix adjust.
Identities = 51/213 (24%), Positives = 79/213 (37%), Gaps = 32/213 (15%)
Query 1009 YLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY 1068
Y + V ++ DI+ V+VNAAN L G GV GA+ A+
Sbjct 812 YARAAGPVHLRVRDIMDPPPGCK--VVVNAANEGLLAGSGVCGAIFANATAALAAN---- 865
Query 1069 IKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPN-------LNAGEDIQLLKAAYENF---- 1116
+ P G + GH +H V P L GE LL+ AY +
Sbjct 866 CRRLAPCPTGEAVATPGHGCGYTHIIHAVAPRRPRDPAALEEGE--ALLERAYRSIVALA 923
Query 1117 --NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQ------VYIAVNDKALYEQVVMDY 1168
+ PLL AG++G +SL+ + RT+ ++I D+A +
Sbjct 924 AARRWACVACPLLGAGVYGWSAAESLRAALAATRTEPVERVSLHICHPDRATLTHASVLV 983
Query 1169 LDNLKPRVEAPKQEEP----PNTEDSKTEEKSV 1197
L R +P EP P + + ++S
Sbjct 984 GAGLAARRVSPPPTEPLASCPAGDPGRPAQRSA 1016
>sp|Q9HXU7|Y3693_PSEAE Macro domain-containing protein PA3693
OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP
104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964
GN=PA3693 PE=4 SV=1
Length=173
Score = 39.7 bits (91), Expect = 0.24, Method: Composition-based stats.
Identities = 41/139 (29%), Positives = 61/139 (44%), Gaps = 19/139 (14%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI + A A IVNAAN L GGGV GA+++A + +L G +
Sbjct 10 DITRLAVDA----IVNAANSSLLGGGGVDGAIHRAAGAELVAAC----RLLHGCKTGEAK 61
Query 1082 LLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAY-------ENFNSQDILLAPLLSAGI 1131
+ G L A +H VGP G+ + +LL + Y E + + P +S GI
Sbjct 62 ITRGFRLPAAHVIHTVGPVWRGGDNGEAELLASCYRRSLALAEQAGAASVAF-PAISCGI 120
Query 1132 FGAKPLQSLQVCVQTVRTQ 1150
+G Q+ + V+ V Q
Sbjct 121 YGYPLEQAAAIAVEEVCRQ 139
>sp|Q9BQ69|MACD1_HUMAN ADP-ribose glycohydrolase MACROD1 OS=Homo
sapiens OX=9606 GN=MACROD1 PE=1 SV=2
Length=325
Score = 40.4 bits (93), Expect = 0.31, Method: Compositional matrix adjust.
Identities = 46/161 (29%), Positives = 75/161 (47%), Gaps = 24/161 (15%)
Query 1000 EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNG 1059
EEP ++ +L + +++ DI K A IVNAAN L GGGV G +++A
Sbjct 140 EEP--RYKKDKQLNEKISLLRSDITKLEVDA----IVNAANSSLLGGGGVDGCIHRAAGP 193
Query 1060 AMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGP---NLNAGEDIQLLKAAYEN 1115
+ +D+ L T G + + G+ L AK +H VGP + L++ Y
Sbjct 194 LL---TDECRTLQSCKT-GKAKITGGYRLPAKYVIHTVGPIAYGEPSASQAAELRSCY-- 247
Query 1116 FNSQDILLA--------PLLSAGIFGAKPLQSLQVCVQTVR 1148
+S D+LL P +S G+FG + ++ + T+R
Sbjct 248 LSSLDLLLEHRLRSVAFPCISTGVFGYPCEAAAEIVLATLR 288
>sp|Q8K4G6|MACD1_RAT ADP-ribose glycohydrolase MACROD1 (Fragment)
OS=Rattus norvegicus OX=10116 GN=Macrod1 PE=2 SV=2
Length=258
Score = 40.0 bits (92), Expect = 0.33, Method: Compositional matrix adjust.
Identities = 39/126 (31%), Positives = 61/126 (48%), Gaps = 16/126 (13%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
IVNAAN L GGGV G +++A + +D+ L T G + + G+ L AK
Sbjct 101 AIVNAANNSLLGGGGVDGCIHRAAGSLL---TDECRTLQNCET-GKAKITCGYRLPAKHV 156
Query 1093 LHVVGPNLNAGEDIQLLKAAYEN--FNSQDILLA--------PLLSAGIFGAKPLQSLQV 1142
+H VGP + G+ A + +S D+LL P +S G+FG ++ +V
Sbjct 157 IHTVGP-IAVGQPTASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEV 215
Query 1143 CVQTVR 1148
+ T+R
Sbjct 216 VLATLR 221
>sp|Q8P5Z8|Y3184_XANCP Macro domain-containing protein XCC3184
OS=Xanthomonas campestris pv. campestris (strain ATCC 33913
/ DSM 3586 / NCPPB 528 / LMG 568 / P 25) OX=190485 GN=XCC3184
PE=4 SV=1
Length=179
Score = 39.3 bits (90), Expect = 0.36, Method: Composition-based stats.
Identities = 36/126 (29%), Positives = 58/126 (46%), Gaps = 11/126 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQK--ESDDYIKLNGPLTVGGSCLLSGHNL-AK 1090
VIVNAAN L GGGV GA+++A + + E+ ++ G + G +L A+
Sbjct 17 VIVNAANESLLGGGGVDGAIHRAAGPRLLEACEALPEVRPGVRCPTGEIRITDGFDLKAR 76
Query 1091 KCLHVVGPNLNAG---EDIQLLKAAYENFNSQDILLA-----PLLSAGIFGAKPLQSLQV 1142
H VGP G E QL +++ + ++ P +S GI+G Q+ ++
Sbjct 77 HIFHTVGPVWRDGKHNEPEQLANCYWQSLKLAEQMMLHSIAFPAISCGIYGYPLYQAARI 136
Query 1143 CVQTVR 1148
V R
Sbjct 137 AVTETR 142
>sp|Q9RUV0|PPDE_DEIRA Phosphatase/phosphodiesterase DR_1281 OS=Deinococcus
radiodurans (strain ATCC 13939 / DSM 20539 / JCM
16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 /
VKM B-1422 / R1) OX=243230 GN=DR_1281 PE=1 SV=1
Length=255
Score = 39.7 bits (91), Expect = 0.41, Method: Composition-based stats.
Identities = 54/177 (31%), Positives = 74/177 (42%), Gaps = 31/177 (18%)
Query 2835 ITREIGFIVPGLPGTVLRA--INGDFL---HFLPRVF-SAVGNICYTPSKLIEYSDFATS 2888
I R + + PG PG R +NG+ L + L RVF AV N T L+E D T
Sbjct 84 IVRPLNYADPGTPGVGWRTFDVNGEKLTVVNLLGRVFMEAVDNPFRTMDALLERDDLGTV 143
Query 2889 ACVLAAECTIFKDAMG--------------KPVPYCYDTNLLEGSISYSELRPDTRYVLM 2934
AE T K+AMG VP DT +L+G +Y + D +
Sbjct 144 FVDFHAEATSEKEAMGWHLAGRVAAVIGTHTHVPTA-DTRILKGGTAY---QTDAGFTGP 199
Query 2935 DGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCE-RSEV-GICLSTSGRWVLNNEHYR 2989
SII + +EG ++ T R+G E R+E+ G+ L G E YR
Sbjct 200 HDSII---GSAIEGPLQRFLTERPH--RYGVAEGRAELNGVALHFEGGKATAAERYR 251
>sp|Q306W8|POLN_EEEV8 Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain PE-3.0815) OX=374597 PE=1 SV=3
Length=2474
Score = 40.8 bits (94), Expect = 0.45, Method: Compositional matrix adjust.
Identities = 43/134 (32%), Positives = 55/134 (41%), Gaps = 34/134 (25%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
DI K A IVNAAN + G GV GAL K GA K P+ G +
Sbjct 1337 DISKSTDEA----IVNAANNKGQPGAGVCGALYKKWPGAFDKV---------PIATGTAH 1383
Query 1082 LLSGHNLAKKCLHVVGPNLNAGEDI---QLLKAAY---------ENFNSQDILLAPLLSA 1129
L+ +H VGPN + ++ Q L Y E +N I PLLS
Sbjct 1384 LVKH---TPNIIHAVGPNFSRVSEVEGNQKLSEVYMDIAKIINRERYNKVSI---PLLST 1437
Query 1130 GIFGA---KPLQSL 1140
GI+ + +QSL
Sbjct 1438 GIYAGGKDRVMQSL 1451
>sp|Q8PHB6|Y3343_XANAC Macro domain-containing protein XAC3343
OS=Xanthomonas axonopodis pv. citri (strain 306) OX=190486
GN=XAC3343 PE=4 SV=2
Length=179
Score = 38.5 bits (88), Expect = 0.51, Method: Composition-based stats.
Identities = 36/126 (29%), Positives = 58/126 (46%), Gaps = 11/126 (9%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQK--ESDDYIKLNGPLTVGGSCLLSGHNL-AK 1090
VIVNAAN L GGGV GA+++A + + E+ ++ G + G +L A+
Sbjct 17 VIVNAANESLLGGGGVDGAIHRAAGPRLLEACEALPQVRPGVRCPTGEIRITDGFDLKAR 76
Query 1091 KCLHVVGPNLNAG---EDIQLLKAAYENFNSQDILLA-----PLLSAGIFGAKPLQSLQV 1142
H VGP G E QL +++ + ++ P +S GI+G Q+ ++
Sbjct 77 HIFHTVGPVWRDGRHNEPEQLANCYWQSLKLAEQMMLHSIAFPAISCGIYGYPLHQAARI 136
Query 1143 CVQTVR 1148
V R
Sbjct 137 AVTETR 142
>sp|Q97AU0|Y719_THEVO Uncharacterized protein TV0719 OS=Thermoplasma
volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 /
NBRC 15438 / GSS1) OX=273116 GN=TV0719 PE=4 SV=1
Length=186
Score = 38.9 bits (89), Expect = 0.52, Method: Compositional matrix adjust.
Identities = 38/115 (33%), Positives = 54/115 (47%), Gaps = 14/115 (12%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP--LTVGGSCLLSGHNL 1088
N IVNAAN L GGGV GA++ + E + + P L G + + SG L
Sbjct 22 NCEAIVNAANPSLMGGGGVDGAIHLKGGKTIDLECAELRRTKWPKGLPPGEADITSGGKL 81
Query 1089 -AKKCLHVVGPNLNAG-EDIQLLKAAYENFNSQDI--------LLAPLLSAGIFG 1133
AK +H VGP ED + L ++Y + S +I + P +S GI+G
Sbjct 82 KAKYVIHTVGPIYRGQEEDAETLYSSY--YRSLEIAKIHGIKCIAFPAISTGIYG 134
>sp|Q9HJ67|Y1105_THEAC Uncharacterized protein Ta1105 OS=Thermoplasma
acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062
/ NBRC 15155 / AMRC-C165) OX=273075 GN=Ta1105 PE=4 SV=2
Length=196
Score = 38.9 bits (89), Expect = 0.54, Method: Composition-based stats.
Identities = 41/144 (28%), Positives = 66/144 (46%), Gaps = 17/144 (12%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP- 1074
+A++ DI + A IVNAAN L GGGV GA++ A + E + P
Sbjct 11 LAVEVGDITESDAEA----IVNAANSSLMGGGGVDGAIHSAAGPELNGELVKIRRERYPN 66
Query 1075 -LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ--LLKAAYEN-------FNSQDILL 1123
L G + + G+ L A +H VGP G + + +L +Y + F DI
Sbjct 67 GLPPGEAVITRGYRLKASHIIHTVGPVWMGGRNGEDDVLYRSYRSCLDLAREFGIHDIAF 126
Query 1124 APLLSAGIFGAKPLQSLQVCVQTV 1147
P LS G +G ++ ++ +++V
Sbjct 127 -PALSTGAYGFPFDRAERIAIRSV 149
>sp|P26627|R1AB_CVMJD Replicase polyprotein 1ab (Fragment) OS=Murine
coronavirus (strain defective JHM) OX=11143 GN=rep PE=3
SV=1
Length=500
Score = 40.0 bits (92), Expect = 0.62, Method: Compositional matrix adjust.
Identities = 43/182 (24%), Positives = 76/182 (42%), Gaps = 13/182 (7%)
Query 1573 PTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSE-AFEYYHTLDESFLGRYMSALNHTK 1631
P ++ D+ K++ + E +T P+D T AF+ ++ S S H K
Sbjct 316 PDQVEAFDIEKVEDSILSELQTELNAPADKTYEDVLAFDAIYSETLSAFYAVPSDETHFK 375
Query 1632 KWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI 1691
V G S NC+L S L+ +Q L ++F +Q+ + +AG F +
Sbjct 376 ------VCGFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKL 429
Query 1692 LAYSNKTV--GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMG 1749
+ + K++ + G V + L + K N C CG + L G++AV + G
Sbjct 430 VKSAPKSIILPQGGYVADFAYFFLSQCSF---KVHANWRCLKCGME-LKLQGLDAVFFYG 485
Query 1750 TL 1751
+
Sbjct 486 DV 487
>sp|Q6PAV8|MACD2_XENLA ADP-ribose glycohydrolase MACROD2 OS=Xenopus
laevis OX=8355 GN=macrod2 PE=2 SV=1
Length=418
Score = 39.7 bits (91), Expect = 0.65, Method: Composition-based stats.
Identities = 40/128 (31%), Positives = 59/128 (46%), Gaps = 22/128 (17%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
IVNAAN L GGGV G +++A+ ++ E + G G + + G+ L AK +
Sbjct 85 IVNAANTSLLGGGGVDGCIHRASGPSLLAECREL----GGCETGQAKITCGYELPAKYVI 140
Query 1094 HVVGP------NLNAGEDI-----QLLKAAYENFNSQDI--LLAPLLSAGIFGAKPLQSL 1140
H VGP N +D+ L A EN DI + P +S GI+G +
Sbjct 141 HTVGPIARGHITPNHKQDLASCYNSSLTLATEN----DIRTIAFPCISTGIYGYPNEPAA 196
Query 1141 QVCVQTVR 1148
V + TV+
Sbjct 197 NVALTTVK 204
>sp|Q9EYI6|Y189_STRNO Macro domain-containing protein in sno 5'region
OS=Streptomyces nogalater OX=38314 PE=4 SV=1
Length=181
Score = 38.1 bits (87), Expect = 0.76, Method: Composition-based stats.
Identities = 42/138 (30%), Positives = 65/138 (47%), Gaps = 14/138 (10%)
Query 1022 DIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY--IKLNGPLTVGG 1079
DI ++ A +VNAAN L GGGV GA+++ A+ E + L G
Sbjct 10 DITRQHADA----LVNAANSSLLGGGGVDGAIHRRGGPAILAECRALRASRYGEGLPTGR 65
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGED-IQLLKAAY-ENFNSQDILLA-----PLLSAGI 1131
+ + +L A+ +H VGP ++ ED LL + Y E+ L A P LS G+
Sbjct 66 AVATTAGDLDARWVIHTVGPVWSSTEDRSDLLASCYRESLRLAGELGARTVAFPALSTGV 125
Query 1132 FGAKPLQSLQVCVQTVRT 1149
+ + ++ V+TVRT
Sbjct 126 YRWPMGDAARIAVETVRT 143
>sp|Q180E9|TIG_CLOD6 Trigger factor OS=Clostridioides difficile
(strain 630) OX=272563 GN=tig PE=3 SV=1
Length=428
Score = 39.7 bits (91), Expect = 0.76, Method: Composition-based stats.
Identities = 45/180 (25%), Positives = 82/180 (46%), Gaps = 29/180 (16%)
Query 1102 AGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALY 1161
AGE++++ E ++SQD+ P+ +F K + V+ + A++D+
Sbjct 209 AGEEVEVNVTFPEEYHSQDLAGKPV----VFNVK--------INDVKVKELSALDDEFAK 256
Query 1162 EQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK----------PVDVKPKIKAC 1211
+ D LD LK V A +EE N D++T SVV+K V ++ +I
Sbjct 257 DTSEFDSLDELKADVRAKLEEEAKNRADAET-RNSVVEKVAENTEIEIPEVMIQHQIDNM 315
Query 1212 IDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGD 1271
++E+ L+ F +LL ++ G+ + + R ED L K + +V + IT +
Sbjct 316 LNELNYQLQYQGFGLQQLL---EMTGRTMEELREE-RKEDAKKLVKSS--LVLEAITKAE 369
>sp|Q922B1|MACD1_MOUSE ADP-ribose glycohydrolase MACROD1 OS=Mus
musculus OX=10090 GN=Macrod1 PE=1 SV=2
Length=323
Score = 38.9 bits (89), Expect = 0.88, Method: Compositional matrix adjust.
Identities = 43/149 (29%), Positives = 71/149 (48%), Gaps = 20/149 (13%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+L + +++ DI K A IVNAAN L GGGV G +++A + +D+
Sbjct 147 QLNEKISLYRGDITKLEVDA----IVNAANSSLLGGGGVDGCIHRAAGSLL---TDECRT 199
Query 1071 LNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYEN--FNSQDILLA--- 1124
L T G + + G+ L AK +H VGP + G+ A + +S D+LL
Sbjct 200 LQNCET-GKAKITCGYRLPAKYVIHTVGP-IAVGQPTASQAAELRSCYLSSLDLLLEHRL 257
Query 1125 -----PLLSAGIFGAKPLQSLQVCVQTVR 1148
P +S G+FG ++ +V + ++R
Sbjct 258 RSVAFPCISTGVFGYPNEEAAEVVLASLR 286
>sp|C4L602|RIMM_EXISA Ribosome maturation factor RimM OS=Exiguobacterium
sp. (strain ATCC BAA-1283 / AT1b) OX=360911 GN=rimM
PE=3 SV=1
Length=172
Score = 37.7 bits (86), Expect = 1.1, Method: Composition-based stats.
Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 11/86 (13%)
Query 2770 VHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCP 2829
VH L H+ Y +EIIG +A+ DG ++ DD F A D W +R G K+D P
Sbjct 89 VHDLDEHEFYYHEIIGCEAVVDGEVIGVV--DDIFETNGAN-DVWVIKRPG--KSDALIP 143
Query 2830 VVAAIITREIG-----FIVPGLPGTV 2850
+ +++ +EI ++ +PG +
Sbjct 144 YIESVV-QEIDVDAKRVVITPIPGMI 168
>sp|Q7TZB9|Y1934_MYCBO Uncharacterized protein Mb1934c OS=Mycobacterium
bovis (strain ATCC BAA-935 / AF2122/97) OX=233413
GN=lppD PE=4 SV=1
Length=358
Score = 38.5 bits (88), Expect = 1.4, Method: Composition-based stats.
Identities = 23/79 (29%), Positives = 40/79 (51%), Gaps = 5/79 (6%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
I NAAN L+H GGVA A+ +A +Q+ES + P+ +G + + ++ A+ +
Sbjct 206 ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAPIGLGEAVETTAGDMPARYVI 261
Query 1094 HVVGPNLNAGEDIQLLKAA 1112
H L +++ AA
Sbjct 262 HAATMELGGPTSGEIITAA 280
>sp|P9WK29|Y1899_MYCTU Uncharacterized protein Rv1899c OS=Mycobacterium
tuberculosis (strain ATCC 25618 / H37Rv) OX=83332
GN=Rv1899c PE=1 SV=1
Length=359
Score = 38.5 bits (88), Expect = 1.4, Method: Composition-based stats.
Identities = 23/79 (29%), Positives = 40/79 (51%), Gaps = 5/79 (6%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
I NAAN L+H GGVA A+ +A +Q+ES + P+ +G + + ++ A+ +
Sbjct 207 ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAPIGLGEAVETTAGDMPARYVI 262
Query 1094 HVVGPNLNAGEDIQLLKAA 1112
H L +++ AA
Sbjct 263 HAATMELGGPTSGEIITAA 281
>sp|P9WK28|Y1899_MYCTO Uncharacterized protein MT1950 OS=Mycobacterium
tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT1950
PE=4 SV=1
Length=374
Score = 38.5 bits (88), Expect = 1.4, Method: Composition-based stats.
Identities = 23/79 (29%), Positives = 40/79 (51%), Gaps = 5/79 (6%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
I NAAN L+H GGVA A+ +A +Q+ES + P+ +G + + ++ A+ +
Sbjct 222 ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAPIGLGEAVETTAGDMPARYVI 277
Query 1094 HVVGPNLNAGEDIQLLKAA 1112
H L +++ AA
Sbjct 278 HAATMELGGPTSGEIITAA 296
>sp|Q985D2|Y7730_RHILO Macro domain-containing protein mll7730
OS=Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 /
MAFF 303099) OX=266835 GN=mll7730 PE=4 SV=1
Length=176
Score = 37.4 bits (85), Expect = 1.5, Method: Compositional matrix adjust.
Identities = 50/170 (29%), Positives = 77/170 (45%), Gaps = 21/170 (12%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
K D + I DI K A IVNAAN L GGGV GA+++A ++ E
Sbjct 3 KALDRIRIHTGDITKLDVDA----IVNAANTLLLGGGGVDGAIHRAAGRELEVECR---M 55
Query 1071 LNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYEN------FNSQDI 1121
LNG VG + + G+ L A+ +H VGP G + +LL + Y + N
Sbjct 56 LNG-CKVGDAKITKGYKLPARHIIHTVGPVWQGGGKGEAELLASCYRSSLELAAANDCRS 114
Query 1122 LLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDN 1171
+ P +S G++ ++ + V TV + + +KA+ E V+ D
Sbjct 115 VAFPAISTGVYRYPKDEATGIAVGTVS----MVIEEKAMPETVIFCCFDE 160
>sp|Q2KHU5|MACD1_BOVIN ADP-ribose glycohydrolase MACROD1 OS=Bos
taurus OX=9913 GN=MACROD1 PE=2 SV=1
Length=325
Score = 38.1 bits (87), Expect = 1.8, Method: Compositional matrix adjust.
Identities = 45/161 (28%), Positives = 74/161 (46%), Gaps = 24/161 (15%)
Query 1000 EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNG 1059
EEP ++ +L + +++ DI K A IVNAAN L GGGV G +++A
Sbjct 140 EEP--KYKKDKQLNEKISLFRGDITKLEVDA----IVNAANSSLLGGGGVDGCIHRAAGP 193
Query 1060 AMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLN---AGEDIQLLKAAYEN 1115
+ +D+ L G + + G+ L AK +H VGP + + L++ Y
Sbjct 194 LL---TDECRTLQN-CETGKAKITCGYRLPAKYVIHTVGPIAHGEPSASQAAELRSCY-- 247
Query 1116 FNSQDILLA--------PLLSAGIFGAKPLQSLQVCVQTVR 1148
+S D+LL P +S G+FG + +V + +R
Sbjct 248 LSSLDLLLEHRLRSAAFPCISTGVFGYPNEAAAEVVLTALR 288
>sp|Q5TB80|CE162_HUMAN Centrosomal protein of 162 kDa OS=Homo
sapiens OX=9606 GN=CEP162 PE=1 SV=2
Length=1403
Score = 38.5 bits (88), Expect = 2.2, Method: Composition-based stats.
Identities = 29/103 (28%), Positives = 46/103 (45%), Gaps = 27/103 (26%)
Query 931 EEEDDAECEEEEIDETCEHEYGTEDDYQGLPL---------EFGASAETVRVEEEEEE-- 979
++E + E + EE+ E ++ ED+Y G PL + + +E + V ++EEE
Sbjct 177 DDEHENESKHEELAENYSDDF--EDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKT 234
Query 980 ---------DWLDDTTE-----QSEIEPEPEPTPEEPVNQFTG 1008
D LD E Q +I P+P PE N+ TG
Sbjct 235 GMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTG 277
>sp|E1PL40|YMDB2_PANVC O-acetyl-ADP-ribose deacetylase 2 OS=Pantoea
vagans (strain C9-1) OX=712898 GN=ymdB2 PE=3 SV=1
Length=171
Score = 36.6 bits (83), Expect = 2.3, Method: Compositional matrix adjust.
Identities = 38/131 (29%), Positives = 54/131 (41%), Gaps = 16/131 (12%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
I+N AN L GGGV GA+++A + E G VG + + L A +
Sbjct 19 IINVANSSLLGGGGVDGAIHRAGGPVILAECQAIRSRQGGCKVGEAVITGAGTLPADYVI 78
Query 1094 HVVGPNLNAG---EDIQLLKAAYENF-----NSQDILLAPLLSAGIFG-------AKPLQ 1138
H VGP + G ED QL F + + P +S GI+G A L
Sbjct 79 HTVGPRWSDGRHNEDTQLKSVYLSCFKLVGHHGIKTVSFPNISTGIYGFPKKRAAAIALD 138
Query 1139 SLQVCVQTVRT 1149
++ C+ RT
Sbjct 139 VIKHCIAENRT 149
>sp|Q99IE5|POLN_RUBVV Non-structural polyprotein p200 OS=Rubella
virus (strain TO-336) OX=376264 PE=3 SV=1
Length=2116
Score = 38.1 bits (87), Expect = 2.6, Method: Compositional matrix adjust.
Identities = 54/228 (24%), Positives = 84/228 (37%), Gaps = 33/228 (14%)
Query 995 PEPTPEEPVNQFT-GYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGAL 1053
P PT +P + Y + V ++ DI+ V+VNAAN L G GV GA+
Sbjct 797 PTPTKADPDSDIVESYARAAGPVHLRVRDIMDPPPGCK--VVVNAANEGLLAGSGVCGAI 854
Query 1054 NKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPN-------LNAGED 1105
A+ + + P G + GH +H V P L GE
Sbjct 855 FANATAALAAD----CRRLAPCPTGEAVATPGHGCGYTHIIHAVAPRRPRDPAALEEGE- 909
Query 1106 IQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTV------RTQVYI 1153
LL+ AY + + PLL AG++G +SL+ + R ++I
Sbjct 910 -ALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAAESLRAALAATRAEPAERVSLHI 968
Query 1154 AVNDKALYEQVVMDYLDNLKPRVEAPKQEEP----PNTEDSKTEEKSV 1197
D+A + L R +P EP P + + ++S
Sbjct 969 CHPDRATLTHASVLVGAGLAARRVSPPPTEPLASCPAGDPGRPAQRSA 1016
>sp|Q99IE7|POLN_RUBVO Non-structural polyprotein p200 OS=Rubella
virus (strain TO-336 vaccine) OX=376265 PE=3 SV=1
Length=2116
Score = 37.7 bits (86), Expect = 3.2, Method: Compositional matrix adjust.
Identities = 54/228 (24%), Positives = 84/228 (37%), Gaps = 33/228 (14%)
Query 995 PEPTPEEPVNQFT-GYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGAL 1053
P PT +P + Y + V ++ DI+ V+VNAAN L G GV GA+
Sbjct 797 PTPTKADPDSDIVESYARAAGPVHLRVRDIMDPPPGCK--VVVNAANEGLLAGSGVCGAI 854
Query 1054 NKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPN-------LNAGED 1105
A+ + + P G + GH +H V P L GE
Sbjct 855 FANATAALAAD----CRRLAPCPTGEAVATPGHGCGYTHIIHAVAPRRPRDPAALEEGE- 909
Query 1106 IQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTV------RTQVYI 1153
LL+ AY + + PLL AG++G +SL+ + R ++I
Sbjct 910 -ALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAAESLRAALAATRAEPAERVSLHI 968
Query 1154 AVNDKALYEQVVMDYLDNLKPRVEAPKQEEP----PNTEDSKTEEKSV 1197
D+A + L R +P EP P + + ++S
Sbjct 969 CHPDRATLTHASVLVGAGLAARRVSPPPTEPLASCPAGDPGRPAQRSA 1016
>sp|A1Z1Q3|MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 OS=Homo
sapiens OX=9606 GN=MACROD2 PE=1 SV=2
Length=425
Score = 37.0 bits (84), Expect = 4.1, Method: Compositional matrix adjust.
Identities = 39/112 (35%), Positives = 55/112 (49%), Gaps = 18/112 (16%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
IVNAAN L GGGV G +++A + E + LNG G + + G++L AK
Sbjct 86 AIVNAANASLLGGGGVDGCIHRAAGPCLLAECRN---LNG-CDTGHAKITCGYDLPAKYV 141
Query 1093 LHVVGP------NLNAGEDI-----QLLKAAYENFNSQDILLAPLLSAGIFG 1133
+H VGP N + ED+ LK EN N + + P +S GI+G
Sbjct 142 IHTVGPIARGHINGSHKEDLANCYKSSLKLVKEN-NIRSVAF-PCISTGIYG 191
>sp|Q3ZX83|TIG_DEHMC Trigger factor OS=Dehalococcoides mccartyi
(strain CBDB1) OX=255470 GN=tig PE=3 SV=1
Length=447
Score = 36.6 bits (83), Expect = 5.4, Method: Composition-based stats.
Identities = 27/115 (23%), Positives = 57/115 (50%), Gaps = 9/115 (8%)
Query 3903 DINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAY----EQAVANGDSEVVLKKLK 3958
+++++ E+ L + EF ++ S Q+ Y EQ VA S +VL KL
Sbjct 308 ELDQIIEQQLQRLQSNVKSPEEFRAMLSQMTPEDMQQRYRPLAEQRVA---SSLVLGKLA 364
Query 3959 KSLNVAKSEFDRDAAMQRKLEKMADQAMTQ--MYKQARSEDKRAKVTSAMQTMLF 4011
+ N+ ++ + DA +++ + D+ + +Y Q+ + D+ ++ +A +TM F
Sbjct 365 TTENLVPNDEEVDAEIEKLITDAGDKKEEEKALYNQSETRDRLIQLLTARKTMAF 419
>sp|A9WSX9|RPOC_RENSM DNA-directed RNA polymerase subunit beta'
OS=Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767
/ JCM 11484 / NBRC 15589 / NCIMB 2235) OX=288705 GN=rpoC
PE=3 SV=1
Length=1299
Score = 37.0 bits (84), Expect = 6.2, Method: Compositional matrix adjust.
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 22/130 (17%)
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLR---SLNLGEVFIAQSKGLY 717
KGQ + + V F+ N L M +D V + +LR L+ G + LY
Sbjct 285 KGQRKTRALKRLKVVNAFLTTKNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLY 344
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
R+ I +L+ L+ L AP+ ++ N E L+ VDS +
Sbjct 345 RRVINRNNRLKRLLDLGAPE-------------------IIVNNEKRMLQEAVDSLFDNG 385
Query 778 IVGTPVCVNG 787
G PV G
Sbjct 386 RRGRPVTGPG 395
>sp|Q6X2U2|POLN_RUBVC Non-structural polyprotein p200 OS=Rubella
virus (strain BRDII) OX=376263 PE=3 SV=1
Length=2116
Score = 37.0 bits (84), Expect = 6.6, Method: Compositional matrix adjust.
Identities = 56/242 (23%), Positives = 90/242 (37%), Gaps = 27/242 (11%)
Query 977 EEEDWLDDTTEQSEIEPEPEPTPE--EPVNQFT-GYLKLTDNVAIKCVDIVKEAQSANPM 1033
E D D + EP TP +P + Y + V ++ +I+
Sbjct 777 EPADRARDAEPEVACEPGGPATPARADPDSDIVESYARAAGPVHLRVRNIMDPPPGCK-- 834
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKC 1092
V+VNAAN L G GV GA+ + ++ ++D +L P G + GH
Sbjct 835 VVVNAANEGLLAGSGVCGAIFASAAASL---AEDCRRL-APCPTGEAVATPGHGCGYAHI 890
Query 1093 LHVVGPNLNAG-----EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQ 1141
+H V P + LL+ AY + + PLL AGI+G +SL+
Sbjct 891 IHAVAPRRPQDPAALEQSEALLERAYRSIVALAAARRWTCVACPLLGAGIYGWSAAESLR 950
Query 1142 VCVQTV------RTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEK 1195
+ R ++I D+A + L R +P EPP + + +
Sbjct 951 AALAAARTEPAERVSLHICHPDRATLMHASVLVGAGLAARRVSPPPTEPPASRPADDPGR 1010
Query 1196 SV 1197
S
Sbjct 1011 SA 1012
>sp|B2GIK0|RPOC_KOCRD DNA-directed RNA polymerase subunit beta'
OS=Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217
/ DC2201) OX=378753 GN=rpoC PE=3 SV=1
Length=1296
Score = 36.6 bits (83), Expect = 7.7, Method: Compositional matrix adjust.
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 22/130 (17%)
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLR---SLNLGEVFIAQSKGLY 717
KGQ + + V F+ N L M +D V + +LR L+ G + LY
Sbjct 285 KGQRKTRALKRLKVVNAFLTTDNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLY 344
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
R+ I +L+ L+ L AP+ ++ N E L+ VDS +
Sbjct 345 RRVINRNNRLKRLLDLGAPE-------------------IIVNNEKRMLQEAVDSLFDNG 385
Query 778 IVGTPVCVNG 787
G PV G
Sbjct 386 RRGRPVTGPG 395
>sp|A1R8V3|RPOC_PAEAT DNA-directed RNA polymerase subunit beta'
OS=Paenarthrobacter aurescens (strain TC1) OX=290340 GN=rpoC
PE=3 SV=1
Length=1299
Score = 36.6 bits (83), Expect = 7.7, Method: Compositional matrix adjust.
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 22/130 (17%)
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLR---SLNLGEVFIAQSKGLY 717
KGQ + + V F+ N L M +D V + +LR L+ G + LY
Sbjct 285 KGQRKTRALKRLKVVNAFLTTNNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLY 344
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
R+ I +L+ L+ L AP+ ++ N E L+ VDS +
Sbjct 345 RRVINRNNRLKRLLDLGAPE-------------------IIVNNEKRMLQEAVDSLFDNG 385
Query 778 IVGTPVCVNG 787
G PV G
Sbjct 386 RRGRPVTGPG 395
>sp|Q8CDI7|CC150_MOUSE Coiled-coil domain-containing protein 150
OS=Mus musculus OX=10090 GN=Ccdc150 PE=2 SV=2
Length=1110
Score = 36.6 bits (83), Expect = 7.7, Method: Composition-based stats.
Identities = 66/253 (26%), Positives = 96/253 (38%), Gaps = 59/253 (23%)
Query 1054 NKATNGAMQKESDDYIKLNGPL----TVGGSCLLSGHNLAKKC------LHVVGPNLN-- 1101
NKAT +++KE ++ I L + V G + L+KKC L VV +
Sbjct 326 NKATQISLKKEHEENIYLKSEILSLQDVSGKAQVLNDQLSKKCSELTSMLQVVKMENSRI 385
Query 1102 AGEDIQLLKAAY----ENFNSQDILLAPLLSAGIFGAKPLQSLQ---------------- 1141
E +LK E F Q++LL A I G LQ++Q
Sbjct 386 IAEHQAILKVEQKMITETFQEQNLLLDAA-HASITGE--LQAVQNEKAQLQIHLDHLILE 442
Query 1142 --VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPK---------QEEPPNTEDS 1190
C+Q + V K L E + LK ++ K Q E TE
Sbjct 443 HNQCLQKSQEAEKRTVVQKELLESTIARLQGELKASLQEKKSLLEKNEWFQREVNKTEKE 502
Query 1191 KTEEKSVVQKPV-DVKPKIKACIDEVTTTLEETKFLTNKLLLF------ADINGKLYH-- 1241
+EK ++K + + K I + T +EE K LTNK+ +D GK+
Sbjct 503 VAKEKCNLEKELAESKEDINVLNQNLQTLMEENKHLTNKMASLEHHKATSDYQGKVEKAL 562
Query 1242 ----DSQNMLRGE 1250
DS+NML E
Sbjct 563 EKITDSKNMLAYE 575
>sp|Q3UYG8|MACD2_MOUSE ADP-ribose glycohydrolase MACROD2 OS=Mus
musculus OX=10090 GN=Macrod2 PE=1 SV=1
Length=475
Score = 36.2 bits (82), Expect = 8.2, Method: Compositional matrix adjust.
Identities = 39/112 (35%), Positives = 55/112 (49%), Gaps = 18/112 (16%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
IVNAAN L GGGV G +++A + E + LNG G + + G++L AK
Sbjct 86 AIVNAANASLLGGGGVDGCIHRAAGPCLLAECRN---LNG-CETGHAKITCGYDLPAKYV 141
Query 1093 LHVVGP------NLNAGEDI-----QLLKAAYENFNSQDILLAPLLSAGIFG 1133
+H VGP N + ED+ LK EN N + + P +S GI+G
Sbjct 142 IHTVGPIARGHINGSHKEDLANCYQSSLKLVKEN-NLRSVAF-PCISTGIYG 191
>sp|B8HD15|RPOC_PSECP DNA-directed RNA polymerase subunit beta'
OS=Pseudarthrobacter chlorophenolicus (strain ATCC 700700
/ DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794
/ A6) OX=452863 GN=rpoC PE=3 SV=1
Length=1299
Score = 36.6 bits (83), Expect = 8.2, Method: Compositional matrix adjust.
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 22/130 (17%)
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLR---SLNLGEVFIAQSKGLY 717
KGQ + + V F+ N L M +D V + +LR L+ G + LY
Sbjct 285 KGQRKTRALKRLKVVNAFLTTNNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLY 344
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
R+ I +L+ L+ L AP+ ++ N E L+ VDS +
Sbjct 345 RRVINRNNRLKRLLDLGAPE-------------------IIVNNEKRMLQEAVDSLFDNG 385
Query 778 IVGTPVCVNG 787
G PV G
Sbjct 386 RRGRPVTGPG 395
>sp|A0JZ92|RPOC_ARTS2 DNA-directed RNA polymerase subunit beta'
OS=Arthrobacter sp. (strain FB24) OX=290399 GN=rpoC PE=3 SV=1
Length=1299
Score = 36.6 bits (83), Expect = 8.2, Method: Compositional matrix adjust.
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 22/130 (17%)
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLR---SLNLGEVFIAQSKGLY 717
KGQ + + V F+ N L M +D V + +LR L+ G + LY
Sbjct 285 KGQRKTRALKRLKVVNAFLTTNNSPLGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLY 344
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
R+ I +L+ L+ L AP+ ++ N E L+ VDS +
Sbjct 345 RRVINRNNRLKRLLDLGAPE-------------------IIVNNEKRMLQEAVDSLFDNG 385
Query 778 IVGTPVCVNG 787
G PV G
Sbjct 386 RRGRPVTGPG 395
>sp|Q9KHE2|Y189_STRGR Macro domain-containing protein in non 5'region
OS=Streptomyces griseus OX=1911 PE=4 SV=1
Length=177
Score = 35.0 bits (79), Expect = 9.1, Method: Composition-based stats.
Identities = 37/127 (29%), Positives = 55/127 (43%), Gaps = 16/127 (13%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATN-----GAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
VIVNAAN L GGGV GA+++ + + Y K G T +G
Sbjct 23 VIVNAANSSLLGGGGVDGAIHRRGGPDILAACRELRASRYGK--GLPTGQAVATTAGRLD 80
Query 1089 AKKCLHVVGPNLNAGEDIQ-LLKAAYE-------NFNSQDILLAPLLSAGIFGAKPLQSL 1140
A+ +H VGP + +D LL + Y ++ I P +S GI+G
Sbjct 81 ARWIVHTVGPVFSGAQDRSALLASCYRESLRLAAELGARSIAF-PAISTGIYGWPMDDGA 139
Query 1141 QVCVQTV 1147
++ V+TV
Sbjct 140 RIAVRTV 146
>sp|P36517|RM04_YEAST Large ribosomal subunit protein uL29m OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=MRPL4 PE=1 SV=2
Length=319
Score = 35.8 bits (81), Expect = 9.2, Method: Composition-based stats.
Identities = 30/97 (31%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query 558 SIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLL 617
SIP+L+ + L + LR + + + LL N + G + S+ LSN +
Sbjct 94 SIPELRHKSFNDLHSLWYNCLREQNVLARENHLLKN-------IVGSTHDEFSE-LSNSI 145
Query 618 GTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLIT 654
TT+ ++R + E SA EFL+D E KFL T
Sbjct 146 RTTMWQIRHVLNERELAYSASREFLQDESERKKFLDT 182
>sp|A7A1V9|RM04_YEAS7 Large ribosomal subunit protein uL29m OS=Saccharomyces
cerevisiae (strain YJM789) OX=307796 GN=MRPL4
PE=3 SV=1
Length=319
Score = 35.8 bits (81), Expect = 9.2, Method: Composition-based stats.
Identities = 30/97 (31%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query 558 SIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLL 617
SIP+L+ + L + LR + + + LL N + G + S+ LSN +
Sbjct 94 SIPELRHKSFNDLHSLWYNCLREQNVLARENHLLKN-------IVGSTHDEFSE-LSNSI 145
Query 618 GTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLIT 654
TT+ ++R + E SA EFL+D E KFL T
Sbjct 146 RTTMWQIRHVLNERELAYSASREFLQDESERKKFLDT 182
>sp|Q60A10|RL11_METCA Large ribosomal subunit protein uL11 OS=Methylococcus
capsulatus (strain ATCC 33009 / NCIMB 11132 /
Bath) OX=243233 GN=rplK PE=3 SV=1
Length=143
Score = 34.3 bits (77), Expect = 9.5, Method: Composition-based stats.
Identities = 34/109 (31%), Positives = 48/109 (44%), Gaps = 12/109 (11%)
Query 1364 LMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITK----LNSLNE 1419
+M C +A A Q KG+ + I Y R F + +K P AS++ K L S +
Sbjct 35 IMEFC---KAFNAQTQNVEKGLPLPVVITVYADRSFTFITKTPPASVLLKKALGLKSGSS 91
Query 1420 PLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTS 1468
T +G VT LEE A+ +K P + + AV T G TS
Sbjct 92 KPNTDKVGTVTRA-QLEEIAK----MKMPDLTAADMDAAVRTIAGSATS 135
>sp|A6QAL0|MNME_SULNB tRNA modification GTPase MnmE OS=Sulfurovum
sp. (strain NBC37-1) OX=387093 GN=mnmE PE=3 SV=1
Length=450
Score = 35.8 bits (81), Expect = 9.8, Method: Composition-based stats.
Identities = 17/33 (52%), Positives = 24/33 (73%), Gaps = 1/33 (3%)
Query 552 LDAANHSIPD-LQRAAVTILDGISEQSLRLVDA 583
+D A IPD + R+ VT LDG+SEQ +++VDA
Sbjct 176 IDYAEEDIPDDIMRSIVTQLDGLSEQIMKIVDA 208
Lambda K H a alpha
0.320 0.135 0.406 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 540007450114
Results from round 2
Query= sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute
respiratory syndrome coronavirus OX=694009 GN=1a PE=1 SV=1
Length=4382
Score E
Sequences producing significant alignments: (Bits) Value
Sequences used in model and found again:
sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute respi... 6415 0.0
sp|P0C6X7|R1AB_SARS Replicase polyprotein 1ab OS=Severe acute res... 6407 0.0
sp|P0C6T7|R1A_BCRP3 Replicase polyprotein 1a OS=Bat coronavirus R... 6365 0.0
sp|P0C6W6|R1AB_BCRP3 Replicase polyprotein 1ab OS=Bat coronavirus... 6356 0.0
sp|P0C6F8|R1A_BCHK3 Replicase polyprotein 1a OS=Bat coronavirus H... 6302 0.0
sp|P0C6W2|R1AB_BCHK3 Replicase polyprotein 1ab OS=Bat coronavirus... 6299 0.0
sp|P0C6F5|R1A_BC279 Replicase polyprotein 1a OS=Bat coronavirus 2... 6295 0.0
sp|P0C6V9|R1AB_BC279 Replicase polyprotein 1ab OS=Bat coronavirus... 6286 0.0
sp|P0DTC1|R1A_SARS2 Replicase polyprotein 1a OS=Severe acute resp... 5997 0.0
sp|P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab OS=Severe acute re... 5995 0.0
sp|P0C6T5|R1A_BCHK5 Replicase polyprotein 1a OS=Bat coronavirus H... 4772 0.0
sp|P0C6W4|R1AB_BCHK5 Replicase polyprotein 1ab OS=Bat coronavirus... 4769 0.0
sp|P0C6T4|R1A_BCHK4 Replicase polyprotein 1a OS=Bat coronavirus H... 4447 0.0
sp|P0C6W3|R1AB_BCHK4 Replicase polyprotein 1ab OS=Bat coronavirus... 4446 0.0
sp|P0C6W1|R1AB_BC133 Replicase polyprotein 1ab OS=Bat coronavirus... 4435 0.0
sp|P0C6F7|R1A_BC133 Replicase polyprotein 1a OS=Bat coronavirus 1... 4435 0.0
sp|P0C6T6|R1A_BCHK9 Replicase polyprotein 1a OS=Bat coronavirus H... 4365 0.0
sp|P0C6W5|R1AB_BCHK9 Replicase polyprotein 1ab OS=Bat coronavirus... 4360 0.0
sp|P0C6U1|R1A_CVBQ Replicase polyprotein 1a OS=Bovine coronavirus... 3743 0.0
sp|P0C6X0|R1AB_CVBQ Replicase polyprotein 1ab OS=Bovine coronavir... 3740 0.0
sp|K9N638|R1A_MERS1 Replicase polyprotein 1a OS=Middle East respi... 3734 0.0
sp|K9N7C7|R1AB_MERS1 Replicase polyprotein 1ab OS=Middle East res... 3729 0.0
sp|P0C6V0|R1A_CVMA5 Replicase polyprotein 1a OS=Murine coronaviru... 3648 0.0
sp|P0C6X9|R1AB_CVMA5 Replicase polyprotein 1ab OS=Murine coronavi... 3647 0.0
sp|P0C6Y0|R1AB_CVMJH Replicase polyprotein 1ab OS=Murine coronavi... 3643 0.0
sp|P0C6V1|R1A_CVMJH Replicase polyprotein 1a OS=Murine coronaviru... 3643 0.0
sp|P0C6X8|R1AB_CVM2 Replicase polyprotein 1ab OS=Murine coronavir... 3641 0.0
sp|P0C6U9|R1A_CVM2 Replicase polyprotein 1a OS=Murine coronavirus... 3641 0.0
sp|P0C6T9|R1A_CVBLU Replicase polyprotein 1a OS=Bovine coronaviru... 3506 0.0
sp|P0C6T8|R1A_CVBEN Replicase polyprotein 1a OS=Bovine coronaviru... 3506 0.0
sp|P0C6W8|R1AB_CVBLU Replicase polyprotein 1ab OS=Bovine coronavi... 3502 0.0
sp|P0C6W7|R1AB_CVBEN Replicase polyprotein 1ab OS=Bovine coronavi... 3502 0.0
sp|P0C6U0|R1A_CVBM Replicase polyprotein 1a OS=Bovine coronavirus... 3479 0.0
sp|P0C6U4|R1A_CVHN2 Replicase polyprotein 1a OS=Human coronavirus... 3476 0.0
sp|P0C6W9|R1AB_CVBM Replicase polyprotein 1ab OS=Bovine coronavir... 3476 0.0
sp|P0C6U7|R1A_CVHOC Replicase polyprotein 1a OS=Human coronavirus... 3474 0.0
sp|P0C6X3|R1AB_CVHN2 Replicase polyprotein 1ab OS=Human coronavir... 3473 0.0
sp|P0C6X4|R1AB_CVHN5 Replicase polyprotein 1ab OS=Human coronavir... 3471 0.0
sp|P0C6U5|R1A_CVHN5 Replicase polyprotein 1a OS=Human coronavirus... 3470 0.0
sp|P0C6X6|R1AB_CVHOC Replicase polyprotein 1ab OS=Human coronavir... 3470 0.0
sp|P0C6U3|R1A_CVHN1 Replicase polyprotein 1a OS=Human coronavirus... 3466 0.0
sp|P0C6X2|R1AB_CVHN1 Replicase polyprotein 1ab OS=Human coronavir... 3464 0.0
sp|P0C6X5|R1AB_CVHNL Replicase polyprotein 1ab OS=Human coronavir... 2614 0.0
sp|P0C6U6|R1A_CVHNL Replicase polyprotein 1a OS=Human coronavirus... 2613 0.0
sp|P0C6U2|R1A_CVH22 Replicase polyprotein 1a OS=Human coronavirus... 2599 0.0
sp|P0C6X1|R1AB_CVH22 Replicase polyprotein 1ab OS=Human coronavir... 2598 0.0
sp|P0C6F6|R1A_BC512 Replicase polyprotein 1a OS=Bat coronavirus 5... 2587 0.0
sp|P0C6W0|R1AB_BC512 Replicase polyprotein 1ab OS=Bat coronavirus... 2585 0.0
sp|P0C6V6|R1A_PEDV7 Replicase polyprotein 1a OS=Porcine epidemic ... 2566 0.0
sp|P0C6Y4|R1AB_PEDV7 Replicase polyprotein 1ab OS=Porcine epidemi... 2565 0.0
sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious ... 2563 0.0
sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious b... 2563 0.0
sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious b... 2562 0.0
sp|P0C6Y3|R1AB_IBVM Replicase polyprotein 1ab OS=Avian infectious... 2556 0.0
sp|P0C6Y2|R1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectiou... 2556 0.0
sp|P0C6Y1|R1AB_IBVB Replicase polyprotein 1ab OS=Avian infectious... 2556 0.0
sp|Q98VG9|R1AB_FIPV Replicase polyprotein 1ab OS=Feline coronavir... 2549 0.0
sp|P0C6V2|R1A_CVPPU Replicase polyprotein 1a OS=Porcine transmiss... 2546 0.0
sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmi... 2544 0.0
sp|B5F961|YMDB_SALA4 O-acetyl-ADP-ribose deacetylase OS=Salmonell... 164 9e-45
sp|B4T2X8|YMDB_SALNS O-acetyl-ADP-ribose deacetylase OS=Salmonell... 164 9e-45
sp|A7MG20|YMDB_CROS8 O-acetyl-ADP-ribose deacetylase OS=Cronobact... 164 1e-44
sp|P67341|YMDB_SALTY O-acetyl-ADP-ribose deacetylase OS=Salmonell... 164 1e-44
sp|P67342|YMDB_SALTI O-acetyl-ADP-ribose deacetylase OS=Salmonell... 164 1e-44
sp|D5CE05|YMDB_ENTCC O-acetyl-ADP-ribose deacetylase OS=Enterobac... 164 1e-44
sp|A4W960|YMDB_ENT38 O-acetyl-ADP-ribose deacetylase OS=Enterobac... 163 3e-44
sp|C9Y0V8|YMDB_CROTZ O-acetyl-ADP-ribose deacetylase OS=Cronobact... 163 4e-44
sp|B5RBF3|YMDB_SALG2 O-acetyl-ADP-ribose deacetylase OS=Salmonell... 162 4e-44
sp|B7LT90|YMDB_ESCF3 O-acetyl-ADP-ribose deacetylase OS=Escherich... 162 4e-44
sp|P0A8D6|YMDB_ECOLI O-acetyl-ADP-ribose deacetylase OS=Escherich... 162 7e-44
sp|P0A8D7|YMDB_ECOL6 O-acetyl-ADP-ribose deacetylase OS=Escherich... 162 7e-44
sp|P0A8D8|YMDB_ECO57 O-acetyl-ADP-ribose deacetylase OS=Escherich... 162 7e-44
sp|D2TT52|YMDB_CITRI O-acetyl-ADP-ribose deacetylase OS=Citrobact... 161 1e-43
sp|Q0T5Z6|YMDB_SHIF8 O-acetyl-ADP-ribose deacetylase OS=Shigella ... 161 2e-43
sp|D3RKJ0|YMDB_KLEVT O-acetyl-ADP-ribose deacetylase OS=Klebsiell... 159 5e-43
sp|B5XXK9|YMDB_KLEP3 O-acetyl-ADP-ribose deacetylase OS=Klebsiell... 159 5e-43
sp|A8AI35|YMDB_CITK8 O-acetyl-ADP-ribose deacetylase OS=Citrobact... 159 5e-43
sp|Q32E73|YMDB_SHIDS O-acetyl-ADP-ribose deacetylase OS=Shigella ... 156 9e-42
sp|Q8EYT0|Y4133_LEPIN Macro domain-containing protein LA_4133 OS=... 148 5e-39
sp|Q72M93|Y3295_LEPIC Macro domain-containing protein LIC_13295 O... 148 5e-39
sp|Q8KAE4|Y2219_CHLTE Macro domain-containing protein CT2219 OS=C... 141 1e-36
sp|Q4J9D2|Y1252_SULAC Uncharacterized protein Saci_1252 OS=Sulfol... 139 6e-36
sp|P0C6F3|R1A_BEV Replicase polyprotein 1a OS=Berne virus OX=1115... 155 1e-35
sp|P0C6V7|R1AB_BEV Replicase polyprotein 1ab OS=Berne virus OX=11... 154 2e-35
sp|Q96XY5|Y2383_SULTO Uncharacterized protein STK_23830 OS=Sulfur... 137 3e-35
sp|Q8ZXT3|Y1111_PYRAE Uncharacterized protein PAE1111 OS=Pyrobacu... 137 5e-35
sp|Q97UU4|Y2899_SACS2 Uncharacterized protein SSO2899 OS=Saccharo... 136 8e-35
sp|Q9WYX8|Y508_THEMA Uncharacterized protein TM_0508 OS=Thermotog... 145 4e-34
sp|Q8RB30|Y995_CALS4 Macro domain-containing protein TTE0995 OS=C... 134 6e-34
sp|P0C6F4|R1A_BRV1 Replicase polyprotein 1a OS=Breda virus 1 OX=3... 148 2e-33
sp|P0C6V8|R1AB_BRV1 Replicase polyprotein 1ab OS=Breda virus 1 OX... 147 2e-33
sp|Q8Y2K1|Y334_RALN1 Macro domain-containing protein RSc0334 OS=R... 129 2e-32
sp|Q87JZ5|Y4103_VIBPA Macro domain-containing protein VPA0103 OS=... 125 4e-31
sp|Q8IXQ6|PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9 O... 135 3e-30
sp|Q2EMV9|PAR14_MOUSE Protein mono-ADP-ribosyltransferase PARP14 ... 136 4e-30
sp|Q8CAS9|PARP9_MOUSE Protein mono-ADP-ribosyltransferase PARP9 O... 134 1e-29
sp|Q460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 ... 133 3e-29
sp|Q8RHQ2|Y1951_FUSNN Uncharacterized protein FN1951 OS=Fusobacte... 120 4e-29
sp|Q9WJC7|POLN_EEVVM Polyprotein P1234 OS=Venezuelan equine encep... 109 9e-22
sp|Q8V294|POLN_EEVVC Polyprotein P1234 OS=Venezuelan equine encep... 109 1e-21
sp|P27282|POLN_EEVVT Polyprotein P1234 OS=Venezuelan equine encep... 108 1e-21
sp|P36328|POLN_EEVVP Polyprotein P1234 OS=Venezuelan equine encep... 108 1e-21
sp|P36327|POLN_EEVV3 Polyprotein P1234 OS=Venezuelan equine encep... 108 1e-21
Sequences not found previously or not previously below threshold:
sp|E1SDF1|YMDB1_PANVC O-acetyl-ADP-ribose deacetylase 1 OS=Pantoe... 143 2e-37
sp|Q8Q0F9|Y177_METMA Macro domain-containing protein MM_0177 OS=M... 132 2e-33
sp|E1PL40|YMDB2_PANVC O-acetyl-ADP-ribose deacetylase 2 OS=Pantoe... 130 5e-33
sp|Q7MTZ7|MACRO_PORGI Macro domain-containing protein PG1779 OS=P... 124 7e-31
sp|Q926Y8|Y2902_LISIN Macro domain-containing protein lin2902 OS=... 124 9e-31
sp|Q71W03|Y2748_LISMF Macro domain-containing protein LMOf2365_27... 124 1e-30
sp|Q8Y3S3|Y2759_LISMO Macro domain-containing protein lmo2759 OS=... 124 2e-30
sp|Q8PHB6|Y3343_XANAC Macro domain-containing protein XAC3343 OS=... 123 2e-30
sp|Q9HXU7|Y3693_PSEAE Macro domain-containing protein PA3693 OS=P... 123 2e-30
sp|Q8TQD0|Y1614_METAC Macro domain-containing protein MA_1614 OS=... 124 2e-30
sp|Q8P5Z8|Y3184_XANCP Macro domain-containing protein XCC3184 OS=... 123 3e-30
sp|Q93SX7|Y189_ACISE Macro domain-containing protein OS=Acinetoba... 123 4e-30
sp|Q88SK6|Y3408_LACPL Macro domain-containing protein lp_3408 OS=... 121 8e-30
sp|Q985D2|Y7730_RHILO Macro domain-containing protein mll7730 OS=... 119 1e-28
sp|Q9ZBG3|Y6450_STRCO Macro domain-containing protein SCO6450 OS=... 118 1e-28
sp|Q9KHE2|Y189_STRGR Macro domain-containing protein in non 5'reg... 117 4e-28
sp|Q9RS39|Y2288_DEIRA Macro domain-containing protein DR_2288 OS=... 116 4e-28
sp|Q3UYG8|MACD2_MOUSE ADP-ribose glycohydrolase MACROD2 OS=Mus mu... 125 5e-28
sp|Q97AU0|Y719_THEVO Uncharacterized protein TV0719 OS=Thermoplas... 116 7e-28
sp|Q6PAV8|MACD2_XENLA ADP-ribose glycohydrolase MACROD2 OS=Xenopu... 123 7e-28
sp|Q44020|YGB2_CUPNE Macro domain-containing protein in gbd 3'reg... 115 9e-28
sp|Q9EYI6|Y189_STRNO Macro domain-containing protein in sno 5'reg... 115 2e-27
sp|A1Z1Q3|MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 OS=Homo s... 120 7e-27
sp|Q9BQ69|MACD1_HUMAN ADP-ribose glycohydrolase MACROD1 OS=Homo s... 115 7e-26
sp|Q2KHU5|MACD1_BOVIN ADP-ribose glycohydrolase MACROD1 OS=Bos ta... 114 1e-25
sp|Q9HJ67|Y1105_THEAC Uncharacterized protein Ta1105 OS=Thermopla... 109 3e-25
sp|Q8K4G6|MACD1_RAT ADP-ribose glycohydrolase MACROD1 (Fragment) ... 110 9e-25
sp|Q922B1|MACD1_MOUSE ADP-ribose glycohydrolase MACROD1 OS=Mus mu... 110 2e-24
sp|O59182|Y1513_PYRHO Uncharacterized protein PH1513 OS=Pyrococcu... 95.5 2e-20
sp|Q9V0Y3|Y656_PYRAB Uncharacterized protein PYRAB06560 OS=Pyroco... 90.9 7e-19
sp|O28751|Y1521_ARCFU ADP-ribose glycohydrolase AF_1521 OS=Archae... 88.6 5e-18
sp|Q8U0P9|Y1536_PYRFU Uncharacterized protein PF1536 OS=Pyrococcu... 81.7 1e-15
sp|Q8NYB7|ADPRH_STAAW Protein-ADP-ribose hydrolase OS=Staphylococ... 81.3 8e-15
sp|Q6GCE6|ADPRH_STAAS Protein-ADP-ribose hydrolase OS=Staphylococ... 81.3 8e-15
sp|Q5HIW9|ADPRH_STAAC Protein-ADP-ribose hydrolase OS=Staphylococ... 81.3 9e-15
sp|Q8P0X2|ADPRH_STRP8 Protein-ADP-ribose hydrolase OS=Streptococc... 81.3 1e-14
sp|Q5XC09|ADPRH_STRP6 Protein-ADP-ribose hydrolase OS=Streptococc... 80.9 1e-14
sp|P0DN70|ADPRH_STRPG Protein-ADP-ribose hydrolase OS=Streptococc... 80.9 1e-14
sp|O67112|Y987_AQUAE Uncharacterized protein aq_987 OS=Aquifex ae... 78.2 1e-14
sp|Q5JER1|Y1890_THEKO Uncharacterized protein TK1890 OS=Thermococ... 78.6 1e-14
sp|P0DC29|ADPRH_STRPQ Protein-ADP-ribose hydrolase OS=Streptococc... 80.9 1e-14
sp|P0DC28|ADPRH_STRP3 Protein-ADP-ribose hydrolase OS=Streptococc... 80.9 1e-14
sp|Q99ZI6|ADPRH_STRP1 Protein-ADP-ribose hydrolase OS=Streptococc... 80.9 1e-14
sp|Q8BCR0|POLN_RUBVN Non-structural polyprotein p200 OS=Rubella v... 84.4 3e-14
sp|P67344|ADPRH_STAAN Protein-ADP-ribose hydrolase OS=Staphylococ... 79.4 3e-14
sp|P67343|ADPRH_STAAM Protein-ADP-ribose hydrolase OS=Staphylococ... 79.4 3e-14
sp|P13889|POLN_RUBVT Non-structural polyprotein p200 OS=Rubella v... 84.0 4e-14
sp|P27283|POLN_SINDO Polyprotein P1234 OS=Sindbis virus subtype O... 83.6 4e-14
sp|P03317|POLN_SINDV Polyprotein P1234 OS=Sindbis virus OX=11034 ... 83.6 5e-14
sp|Q93RG0|ADPRH_TREMD Protein-ADP-ribose hydrolase OS=Treponema m... 79.0 5e-14
sp|Q7TZB9|Y1934_MYCBO Uncharacterized protein Mb1934c OS=Mycobact... 80.5 5e-14
sp|P9WK29|Y1899_MYCTU Uncharacterized protein Rv1899c OS=Mycobact... 80.5 5e-14
sp|P9WK28|Y1899_MYCTO Uncharacterized protein MT1950 OS=Mycobacte... 80.5 6e-14
sp|O75367|H2AY_HUMAN Core histone macro-H2A.1 OS=Homo sapiens OX=... 80.5 7e-14
sp|Q02874|H2AY_RAT Core histone macro-H2A.1 OS=Rattus norvegicus ... 80.5 7e-14
sp|Q6GJZ1|ADPRH_STAAR Protein-ADP-ribose hydrolase OS=Staphylococ... 78.6 7e-14
sp|Q9QZQ8|H2AY_MOUSE Core histone macro-H2A.1 OS=Mus musculus OX=... 80.1 8e-14
sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog OS=Nematostella vecte... 81.3 9e-14
sp|O93327|H2AY_CHICK Core histone macro-H2A.1 OS=Gallus gallus OX... 79.8 1e-13
sp|P13896|POLN_WEEV Polyprotein P1234 OS=Western equine encephali... 82.5 1e-13
sp|Q5XXP4|POLN_CHIK3 Polyprotein P1234 OS=Chikungunya virus (stra... 81.7 2e-13
sp|Q4QXJ8|POLN_EEEVF Polyprotein P1234 OS=Eastern equine encephal... 81.3 3e-13
sp|Q8JUX6|POLN_CHIKS Polyprotein P1234 OS=Chikungunya virus (stra... 80.9 3e-13
sp|Q6X2U2|POLN_RUBVC Non-structural polyprotein p200 OS=Rubella v... 80.9 3e-13
sp|O40955|POLN_RUBVR Non-structural polyprotein p200 OS=Rubella v... 80.5 4e-13
sp|Q86924|POLN_AURAV Polyprotein P1234 OS=Aura virus OX=44158 PE=... 80.1 6e-13
sp|Q6X2U4|POLN_RUBVB Non-structural polyprotein p200 OS=Rubella v... 79.8 7e-13
sp|O90368|POLN_ONNVS Polyprotein P1234 OS=O'nyong-nyong virus (st... 79.4 1e-12
sp|O90370|POLN_ONNVI Polyprotein P1234 OS=O'nyong-nyong virus (st... 79.4 1e-12
sp|P13886|POLN_ONNVG Polyprotein P1234 OS=O'nyong-nyong virus (st... 78.6 2e-12
sp|Q306W6|POLN_EEEV1 Polyprotein P1234 OS=Eastern equine encephal... 78.2 2e-12
sp|Q306W8|POLN_EEEV8 Polyprotein P1234 OS=Eastern equine encephal... 78.2 2e-12
sp|Q99IE5|POLN_RUBVV Non-structural polyprotein p200 OS=Rubella v... 77.1 4e-12
sp|Q99IE7|POLN_RUBVO Non-structural polyprotein p200 OS=Rubella v... 77.1 4e-12
sp|P87515|POLN_BFV Polyprotein P1234 OS=Barmah forest virus OX=11... 76.7 6e-12
sp|Q6QLN1|POLN_AHEV Non-structural polyprotein pORF1 OS=Avian hep... 75.5 1e-11
sp|P13888|POLN_RRVT Polyprotein nsP1234 (Fragment) OS=Ross river ... 75.5 1e-11
sp|Q9J6K9|POLN_RUBVD Non-structural polyprotein p200 OS=Rubella v... 75.1 2e-11
sp|P13887|POLN_RRVN Polyprotein P1234 OS=Ross river virus (strain... 75.1 2e-11
sp|Q8QZ73|POLN_MAYAB Polyprotein P1234 OS=Mayaro virus (strain Br... 74.0 4e-11
sp|Q8QL53|POLN_SLDV Polyprotein P1234 OS=Sleeping disease virus O... 73.6 5e-11
sp|Q9YBE9|Y1648_AERPE Uncharacterized protein APE_1648.1 OS=Aerop... 67.0 1e-10
sp|Q5XGM5|GDAP2_XENLA Ganglioside-induced differentiation-associa... 70.9 1e-10
sp|Q86500|POLN_RUBVM Non-structural polyprotein p200 OS=Rubella v... 71.3 3e-10
sp|Q5Y389|POLN_GETV Polyprotein P1234 OS=Getah virus OX=59300 PE=... 71.3 3e-10
sp|Q9JGL0|POLN_SAGV Polyprotein P1234 OS=Sagiyama virus OX=59303 ... 71.3 3e-10
sp|Q8JJX1|POLN_SPDV Polyprotein P1234 OS=Salmon pancreas disease ... 70.9 3e-10
sp|Q2KIX2|GDAP2_BOVIN Ganglioside-induced differentiation-associa... 69.0 6e-10
sp|Q9NXN4|GDAP2_HUMAN Ganglioside-induced differentiation-associa... 68.6 8e-10
sp|Q66HX8|GDAP2_DANRE Ganglioside-induced differentiation-associa... 67.8 2e-09
sp|Q66H63|GDAP2_RAT Ganglioside-induced differentiation-associate... 66.7 3e-09
sp|Q9DBL2|GDAP2_MOUSE Ganglioside-induced differentiation-associa... 66.7 4e-09
sp|Q460N3|PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15 ... 66.7 4e-09
sp|Q4R678|GDAP2_MACFA Ganglioside-induced differentiation-associa... 65.1 9e-09
sp|Q5CZL1|GDAP2_XENTR Ganglioside-induced differentiation-associa... 64.3 2e-08
sp|Q9P0M6|H2AW_HUMAN Core histone macro-H2A.2 OS=Homo sapiens OX=... 62.8 4e-08
sp|Q8CCK0|H2AW_MOUSE Core histone macro-H2A.2 OS=Mus musculus OX=... 60.9 1e-07
sp|Q9YLR1|POLN_HEVUS Non-structural polyprotein pORF1 OS=Hepatiti... 60.5 5e-07
sp|Q7JUR6|GDAP2_DROME Protein GDAP2 homolog OS=Drosophila melanog... 57.4 3e-06
sp|A0A0D2UG83|H2AY_CAPO3 Histone macroH2A1.1 OS=Capsaspora owczar... 56.6 3e-06
sp|Q81862|POLN_HEVCH Non-structural polyprotein pORF1 OS=Hepatiti... 57.4 4e-06
sp|Q008X5|R1A_WBV24 Replicase polyprotein 1a OS=White bream virus... 57.0 5e-06
sp|Q008X6|R1AB_WBV24 Replicase polyprotein 1ab OS=White bream vir... 57.0 5e-06
sp|Q6J8G2|POLN_HEVMG Non-structural polyprotein pORF1 OS=Hepatiti... 56.6 6e-06
sp|P33424|POLN_HEVPA Non-structural polyprotein pORF1 OS=Hepatiti... 56.3 8e-06
sp|P29324|POLN_HEVBU Non-structural polyprotein pORF1 OS=Hepatiti... 56.3 8e-06
sp|Q292F9|GDAP2_DROPS Protein GDAP2 homolog OS=Drosophila pseudoo... 55.5 9e-06
sp|Q03495|POLN_HEVME Non-structural polyprotein pORF1 OS=Hepatiti... 55.9 1e-05
sp|Q9M041|BH140_ARATH Transcription factor bHLH140 OS=Arabidopsis... 54.7 2e-05
sp|Q9WC28|POLN_HEVHY Non-structural polyprotein pORF1 OS=Hepatiti... 53.9 5e-05
sp|Q04610|POLN_HEVMY Non-structural polyprotein pORF1 OS=Hepatiti... 53.2 8e-05
sp|Q9IVZ9|POLN_HEVCT Non-structural polyprotein pORF1 OS=Hepatiti... 53.2 8e-05
sp|P08411|POLN_SFV Polyprotein P1234 OS=Semliki forest virus OX=1... 49.3 0.001
sp|P26627|R1AB_CVMJD Replicase polyprotein 1ab (Fragment) OS=Muri... 45.5 0.011
sp|Q5UQ32|RPO6_MIMIV DNA-directed RNA polymerase subunit 6 OS=Aca... 40.9 0.27
sp|Q4FRM3|RS20_PSYA2 Small ribosomal subunit protein bS20 OS=Psyc... 37.0 0.40
sp|Q91ZC6|MRGA6_MOUSE Mas-related G-protein coupled receptor memb... 39.7 0.47
sp|Q2FQC0|KUP_METHJ Probable potassium transport system protein K... 40.5 0.48
sp|Q3KNA1|MRGB2_MOUSE Mas-related G-protein coupled receptor memb... 40.1 0.49
sp|B9JA28|ATP6_RHIR8 ATP synthase subunit a OS=Rhizobium rhizogen... 39.3 0.60
sp|Q1RGZ3|ATP6_RICBR ATP synthase subunit a OS=Rickettsia bellii ... 38.9 0.64
sp|A8GUJ3|ATP6_RICB8 ATP synthase subunit a OS=Rickettsia bellii ... 38.9 0.65
sp|Q51151|LCBA_NEIMI Capsular polysaccharide phosphotransferase O... 39.3 0.73
sp|B0R461|HTR6_HALS3 Transducer protein Htr6 OS=Halobacterium sal... 39.3 1.0
sp|P15576|NU1M_LEITA NADH-ubiquinone oxidoreductase chain 1 OS=Le... 38.9 1.0
sp|Q71SS4|DERL1_BOVIN Derlin-1 OS=Bos taurus OX=9913 GN=DERL1 PE=... 38.2 1.2
sp|Q1RH22|Y1261_RICBR Uncharacterized lipoprotein RBE_1261 OS=Ric... 39.3 1.3
sp|Q9BUN8|DERL1_HUMAN Derlin-1 OS=Homo sapiens OX=9606 GN=DERL1 P... 38.2 1.3
sp|Q67ES1|TR113_RAT Taste receptor type 2 member 113 OS=Rattus no... 38.5 1.4
sp|Q5R9W3|DERL1_PONAB Derlin-1 OS=Pongo abelii OX=9601 GN=DERL1 P... 38.2 1.4
sp|Q37376|NU2M_ACACA NADH-ubiquinone oxidoreductase chain 2 OS=Ac... 38.5 1.4
sp|Q9TC94|YMF16_NEPOL Uncharacterized tatC-like protein ymf16 OS=... 37.8 1.5
sp|Q92JP0|ATP6_RICCN ATP synthase subunit a OS=Rickettsia conorii... 37.8 1.6
sp|A8F0C9|ATP6_RICM5 ATP synthase subunit a OS=Rickettsia massili... 37.8 1.6
sp|C3PM51|ATP6_RICAE ATP synthase subunit a OS=Rickettsia africae... 37.8 1.6
sp|Q99J56|DERL1_MOUSE Derlin-1 OS=Mus musculus OX=10090 GN=Derl1 ... 37.8 1.7
sp|P04540|NU5M_TRYBB NADH-ubiquinone oxidoreductase chain 5 OS=Tr... 38.5 1.7
sp|Q03F26|TIG_PEDPA Trigger factor OS=Pediococcus pentosaceus (st... 38.2 1.7
sp|C4K0P3|ATP6_RICPU ATP synthase subunit a OS=Rickettsia peacock... 37.4 2.1
sp|A8GQF6|ATP6_RICRS ATP synthase subunit a OS=Rickettsia rickett... 37.4 2.3
sp|B0BVU2|ATP6_RICRO ATP synthase subunit a OS=Rickettsia rickett... 37.4 2.3
sp|Q68XQ1|ATP6_RICTY ATP synthase subunit a OS=Rickettsia typhi (... 37.0 2.7
sp|Q09887|YC9D_SCHPO Uncharacterized amino-acid permease C584.13 ... 37.8 2.8
sp|Q1QA59|RS20_PSYCK Small ribosomal subunit protein bS20 OS=Psyc... 34.7 3.0
sp|Q00167|VG78_ICHVA Putative zinc-binding protein ORF78 OS=Ictal... 37.4 3.0
sp|Q4UNH7|ATP6_RICFE ATP synthase subunit a OS=Rickettsia felis (... 36.6 3.4
sp|Q4WFQ4|ABCH_ASPFU ABC multidrug transporter H OS=Aspergillus f... 37.8 3.6
sp|Q6Q487|CALX_ASPFU Calnexin homolog OS=Aspergillus fumigatus (s... 37.4 3.8
sp|Q12UQ9|SYM_METBU Methionine--tRNA ligase OS=Methanococcoides b... 37.4 3.8
sp|P36819|VE7_HPV12 Protein E7 OS=Human papillomavirus 12 OX=1060... 34.7 4.1
sp|Q9UTG3|YKEE_SCHPO Uncharacterized protein C1805.14 OS=Schizosa... 37.0 4.2
sp|Q91ZC7|MRGA5_MOUSE Mas-related G-protein coupled receptor memb... 36.6 4.2
sp|A8GLV8|ATP6_RICAH ATP synthase subunit a OS=Rickettsia akari (... 36.6 4.4
sp|Q86X53|ERIC1_HUMAN Glutamate-rich protein 1 OS=Homo sapiens OX... 37.0 4.5
sp|Q864G6|MSHR_ALOSE Melanocyte-stimulating hormone receptor OS=A... 36.6 4.9
sp|Q5A1V3|POA1_CANAL ADP-ribose 1''-phosphate phosphatase OS=Cand... 35.5 5.4
sp|Q8SR69|IPYR_ENCCU Inorganic pyrophosphatase OS=Encephalitozoon... 36.2 6.0
sp|D4AVD4|CALX_ARTBC Calnexin homolog ARB_00147 OS=Arthroderma be... 36.6 6.0
sp|P9WP37|QCRB_MYCTU Cytochrome bc1 complex cytochrome b subunit ... 36.6 6.0
sp|P9WP36|QCRB_MYCTO Cytochrome bc1 complex cytochrome b subunit ... 36.6 6.0
sp|P63886|QCRB_MYCBO Cytochrome bc1 complex cytochrome b subunit ... 36.6 6.0
sp|F4KIB2|TMN8_ARATH Transmembrane 9 superfamily member 8 OS=Arab... 36.6 6.3
sp|P03318|POLN_MIDDV Polyprotein nsP1234 (Fragment) OS=Middelburg... 37.0 6.3
sp|Q12019|MDN1_YEAST Midasin OS=Saccharomyces cerevisiae (strain ... 37.0 6.8
sp|O31352|MTAD_BACC1 5-methylthioadenosine/S-adenosylhomocysteine... 36.2 7.5
sp|Q7VRW4|NUON_BLOFL NADH-quinone oxidoreductase subunit N OS=Blo... 36.2 8.3
sp|Q9SJM4|STKLI_ARATH GLABROUS1 enhancer-binding protein-like 3 O... 35.8 9.1
sp|B7IS56|MTAD_BACC2 5-methylthioadenosine/S-adenosylhomocysteine... 35.8 9.1
sp|P75354|DNAJM_MYCPN DnaJ-like protein MG200 homolog OS=Mycoplas... 36.2 9.1
sp|Q85BG0|NU4C_ANTAG NAD(P)H-quinone oxidoreductase chain 4, chlo... 35.8 9.9
sp|P13830|RESA_PLAFF Ring-infected erythrocyte surface antigen OS... 36.2 9.9
>sp|P0C6U8|R1A_SARS Replicase polyprotein 1a OS=Severe acute respiratory
syndrome coronavirus OX=694009 GN=1a PE=1 SV=1
Length=4382
Score = 6415 bits (16643), Expect = 0.0, Method: Composition-based stats.
Identities = 4382/4382 (100%), Positives = 4382/4382 (100%), Gaps = 0/4382 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
Sbjct 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL
Sbjct 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY
Sbjct 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV
Sbjct 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
Sbjct 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC
Sbjct 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS
Sbjct 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
Query 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL
Sbjct 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
Query 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
Sbjct 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
Query 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP
Sbjct 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
Query 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT
Sbjct 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
Query 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR
Sbjct 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
Query 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
Sbjct 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
Query 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG
Sbjct 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
Query 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL
Sbjct 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
Query 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL
Sbjct 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
Query 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
Sbjct 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
Query 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
Sbjct 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC
Sbjct 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
Query 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK
Sbjct 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
Query 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
Sbjct 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
Query 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF
Sbjct 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
Query 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE
Sbjct 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
Query 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA
Sbjct 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
Query 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
Sbjct 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
Query 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL
Sbjct 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
Query 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA
Sbjct 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
Query 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW
Sbjct 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
Query 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
Sbjct 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
Query 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP
Sbjct 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
Query 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF
Sbjct 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
Query 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS
Sbjct 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
Query 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
Sbjct 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
Query 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE
Sbjct 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
Query 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA
Sbjct 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
Query 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG
Sbjct 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
Sbjct 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ
Sbjct 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
Query 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA
Sbjct 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
Query 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL
Sbjct 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
Query 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
Sbjct 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
Query 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ
Sbjct 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
Query 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ
Sbjct 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
Query 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR
Sbjct 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
Query 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
Sbjct 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
Query 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK
Sbjct 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
Query 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
Sbjct 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
Query 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
Sbjct 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
Query 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
Sbjct 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV
Sbjct 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
Query 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN
Sbjct 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
Query 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY
Sbjct 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
Query 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
Sbjct 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
Query 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG
Sbjct 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
Query 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS
Sbjct 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
Query 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND
Sbjct 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
Query 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
Sbjct 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
Query 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC
Sbjct 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP
Sbjct 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY
Sbjct 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
Sbjct 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF
Sbjct 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
Query 4381 AV 4382
AV
Sbjct 4381 AV 4382
>sp|P0C6X7|R1AB_SARS Replicase polyprotein 1ab OS=Severe acute
respiratory syndrome coronavirus OX=694009 GN=rep PE=1 SV=1
Length=7073
Score = 6407 bits (16621), Expect = 0.0, Method: Composition-based stats.
Identities = 4378/4378 (100%), Positives = 4378/4378 (100%), Gaps = 0/4378 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
Sbjct 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL
Sbjct 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY
Sbjct 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV
Sbjct 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
Sbjct 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC
Sbjct 961 PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS
Sbjct 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
Query 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL
Sbjct 1081 CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL 1140
Query 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
Sbjct 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK 1200
Query 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP
Sbjct 1201 PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP 1260
Query 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT
Sbjct 1261 YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT 1320
Query 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR
Sbjct 1321 ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR 1380
Query 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
Sbjct 1381 KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR 1440
Query 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG
Sbjct 1441 CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG 1500
Query 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL
Sbjct 1501 VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL 1560
Query 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL
Sbjct 1561 VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL 1620
Query 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
Sbjct 1621 GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR 1680
Query 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
Sbjct 1681 AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT 1740
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC
Sbjct 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC 1800
Query 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK
Sbjct 1801 ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK 1860
Query 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
Sbjct 1861 LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ 1920
Query 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF
Sbjct 1921 MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF 1980
Query 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE
Sbjct 1981 KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE 2040
Query 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA
Sbjct 2041 CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA 2100
Query 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
Sbjct 2101 THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT 2160
Query 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL
Sbjct 2161 KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL 2220
Query 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA
Sbjct 2221 ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA 2280
Query 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW
Sbjct 2281 LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW 2340
Query 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
Sbjct 2341 LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC 2400
Query 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP
Sbjct 2401 TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP 2460
Query 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF
Sbjct 2461 TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF 2520
Query 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS
Sbjct 2521 DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS 2580
Query 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
Sbjct 2581 VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL 2640
Query 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE
Sbjct 2641 EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE 2700
Query 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA
Sbjct 2701 QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA 2760
Query 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG
Sbjct 2761 ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG 2820
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
Sbjct 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ
Sbjct 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ 2940
Query 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA
Sbjct 2941 FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA 3000
Query 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL
Sbjct 3001 MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL 3060
Query 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
Sbjct 3061 LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI 3120
Query 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ
Sbjct 3121 YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ 3180
Query 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ
Sbjct 3181 YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ 3240
Query 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR
Sbjct 3241 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR 3300
Query 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
Sbjct 3301 KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG 3360
Query 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK
Sbjct 3361 SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK 3420
Query 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
Sbjct 3421 FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE 3480
Query 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
Sbjct 3481 PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC 3540
Query 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
Sbjct 3541 SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA 3600
Query 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV
Sbjct 3601 CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV 3660
Query 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN
Sbjct 3661 MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN 3720
Query 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY
Sbjct 3721 YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY 3780
Query 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
Sbjct 3781 FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS 3840
Query 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG
Sbjct 3841 DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG 3900
Query 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS
Sbjct 3901 AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS 3960
Query 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND
Sbjct 3961 LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND 4020
Query 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
Sbjct 4021 ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD 4080
Query 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC
Sbjct 4081 ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC 4140
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP
Sbjct 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY
Sbjct 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
Sbjct 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN
Sbjct 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
>sp|P0C6T7|R1A_BCRP3 Replicase polyprotein 1a OS=Bat coronavirus
Rp3/2004 OX=349344 GN=1a PE=3 SV=1
Length=4380
Score = 6365 bits (16512), Expect = 0.0, Method: Composition-based stats.
Identities = 4232/4383 (97%), Positives = 4302/4383 (98%), Gaps = 4/4383 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLG+NEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLK+GTCG+VELEKGV
Sbjct 1 MESLVLGINEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKSGTCGIVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQ EQPYVFIKRSDA T+HGH+V ELVAE+DG+QYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQPEQPYVFIKRSDAQGTDHGHRVRELVAELDGVQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSG LRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGVLRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A+TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCRDH HEIAW
Sbjct 181 ALTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCRDHGHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGP TCGYL
Sbjct 301 RSVYPVATPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVSEGPNTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHS ADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSAADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDF LNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFQLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKP+KGAWNIGQ RSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPIKGAWNIGQHRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSIPDLQRAAVTILD ISEQSLRLVDAMVYTS+LLTNSVIIMAY
Sbjct 541 AGVIRSIFSRTLDAANHSIPDLQRAAVTILDSISEQSLRLVDAMVYTSNLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLL TTVEKLRPIF WIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLDTTVEKLRPIFAWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCF+DVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFVDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIK EQYCALSPGLLATNNVFRLKGGAP KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLEIKANEQYCALSPGLLATNNVFRLKGGAPTKGVTFGEDTVVEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDE-TCEHEYGTEDDYQG 959
WSVATFYLFDD+GEE SSRMYCSFYPPDEEE+ + EEEE+ E TCEHEYGTE+DY+G
Sbjct 901 WSVATFYLFDDSGEEKLSSRMYCSFYPPDEEEDCEEYEEEEEVSERTCEHEYGTEEDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS + ++VEE+EEEDWLDD E EPEPEP EEPVNQ TGYLKLTDNVAIK
Sbjct 961 LPLEFGASTDIIQVEEQEEEDWLDD---AVEAEPEPEPLHEEPVNQLTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIV+EAQ+ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD YIKLNGPLTVGG
Sbjct 1018 CVDIVEEAQNANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDHYIKLNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
LQ+CVQTVRTQVYI VNDK LYEQVVMDYLD+LKP+VEAPKQE P E K +EKSVVQ
Sbjct 1138 LQMCVQTVRTQVYIVVNDKVLYEQVVMDYLDSLKPKVEAPKQEVLPKAEYPKVDEKSVVQ 1197
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
K +DVKPKIKACIDEVTTTLEETKFLTNKLLLF DINGKLY DS+NMLRGEDMSFLEKDA
Sbjct 1198 KTIDVKPKIKACIDEVTTTLEETKFLTNKLLLFTDINGKLYQDSKNMLRGEDMSFLEKDA 1257
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVP++EYITTYPGQGCAGYTLEEAK
Sbjct 1258 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPINEYITTYPGQGCAGYTLEEAK 1317
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PNAKEEILGTVSWNLREMLAHAEETRKLMP+CMDVRAIMATIQ
Sbjct 1318 TALKKCKSAFYVLPSETPNAKEEILGTVSWNLREMLAHAEETRKLMPVCMDVRAIMATIQ 1377
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA
Sbjct 1378 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1437
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPA+VSVSSPDAVTTYNGYLTSSSKTSE+HFVETVSLAGSYRDWSYSGQRTEL
Sbjct 1438 RCMRSLKAPAIVSVSSPDAVTTYNGYLTSSSKTSEDHFVETVSLAGSYRDWSYSGQRTEL 1497
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRG+KIVYHTLESPV+FHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHTQ
Sbjct 1498 GVEFLKRGEKIVYHTLESPVKFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1557
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
LVDMSMTYGQQ GPTYL+GADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF
Sbjct 1558 LVDMSMTYGQQLGPTYLEGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1617
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1618 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRA 1677
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1678 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1737
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
TGVEAVMYMGTLSYDNLK GVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL
Sbjct 1738 TGVEAVMYMGTLSYDNLKMGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1797
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY
Sbjct 1798 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1857
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL+PTQPLPNASFDNFKLTCSNTKFADDLN
Sbjct 1858 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLIPTQPLPNASFDNFKLTCSNTKFADDLN 1917
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT
Sbjct 1918 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1977
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT EEVVENPTIQKEVI
Sbjct 1978 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTPEEVVENPTIQKEVI 2037
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPSDEGVKVTQEL HEDLMAAYVENTSITIKKPNELSLALGLKTI
Sbjct 2038 ECDVKTTEVVGNVILKPSDEGVKVTQELDHEDLMAAYVENTSITIKKPNELSLALGLKTI 2097
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHGIAAINSVPW KILAYVKPFLGQAA+TTSNCAKRL QR+FNNYMPYV TLLFQLCTF
Sbjct 2098 ATHGIAAINSVPWGKILAYVKPFLGQAAVTTSNCAKRLVQRMFNNYMPYVLTLLFQLCTF 2157
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRIRASLPTTIAKNSV+ + +LCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS
Sbjct 2158 TKSTNSRIRASLPTTIAKNSVRGIVRLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2217
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
LI VTAA GVLLSNFGAPSYC+GVRE YLNSSNVTTMDFCEGSFPCS+CLSGLDSLDSYP
Sbjct 2218 LIYVTAALGVLLSNFGAPSYCSGVRESYLNSSNVTTMDFCEGSFPCSVCLSGLDSLDSYP 2277
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLTILGLAAEW AYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS
Sbjct 2278 ALETIQVTISSYKLDLTILGLAAEWFFAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2337
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2338 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2397
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2398 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2457
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2458 PTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2517
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2518 FDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2577
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSA+RQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2578 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSASRQGVVDTDVDTKDVIECLKLSHHSD 2637
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVA+SHNVSLIWNVKDYMSLS
Sbjct 2638 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVARSHNVSLIWNVKDYMSLS 2697
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVST FK+MLKATLLCVL
Sbjct 2698 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTWFKIMLKATLLCVL 2757
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AALVCYIVMPVH LS+H GYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2758 AALVCYIVMPVHILSVHGGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2817
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2818 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2877
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDF+TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2878 IEYSDFSTSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2937
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPN YLEGSVRVVTTFDAEYCRHGTCERSE GICLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2938 QFPNAYLEGSVRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALPGVFCGVD 2997
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2998 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3057
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LFLMSFTILCL PAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3058 PLFLMSFTILCLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3117
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFFNNYLRKRV+FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT
Sbjct 3118 IYVFCISLKHFHWFFNNYLRKRVVFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3177
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3178 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3237
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI
Sbjct 3238 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3297
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3298 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3357
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT VHAGTDLEG
Sbjct 3358 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTEVHAGTDLEG 3417
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3418 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3477
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3478 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3537
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFK+IVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA+A
Sbjct 3538 CSGVTFQGKFKRIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAVA 3597
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3598 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3657
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS
Sbjct 3658 VMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3717
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3718 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3777
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3778 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3837
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3838 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3897
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK
Sbjct 3898 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3957
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFDR+AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3958 SLNVAKSEFDRNAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4017
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4018 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4077
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINM+NS NLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4078 DADSKIVQLSEINMENSSNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4137
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4138 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4197
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYL+FIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4198 PKVKYLHFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4257
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4258 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4317
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNG 4379
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLNG
Sbjct 4318 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLNG 4377
Query 4380 FAV 4382
FAV
Sbjct 4378 FAV 4380
>sp|P0C6W6|R1AB_BCRP3 Replicase polyprotein 1ab OS=Bat coronavirus
Rp3/2004 OX=349344 GN=rep PE=3 SV=1
Length=7071
Score = 6356 bits (16489), Expect = 0.0, Method: Composition-based stats.
Identities = 4228/4379 (97%), Positives = 4298/4379 (98%), Gaps = 4/4379 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLG+NEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLK+GTCG+VELEKGV
Sbjct 1 MESLVLGINEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKSGTCGIVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQ EQPYVFIKRSDA T+HGH+V ELVAE+DG+QYGRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQPEQPYVFIKRSDAQGTDHGHRVRELVAELDGVQYGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSG LRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGVLRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A+TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCRDH HEIAW
Sbjct 181 ALTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCRDHGHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGP TCGYL
Sbjct 301 RSVYPVATPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVSEGPNTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPEIGPEHS ADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEIGPEHSAADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDF LNEEVAIILASF
Sbjct 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFQLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKP+KGAWNIGQ RSVLTPLCGFPSQA
Sbjct 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPIKGAWNIGQHRSVLTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSIPDLQRAAVTILD ISEQSLRLVDAMVYTS+LLTNSVIIMAY
Sbjct 541 AGVIRSIFSRTLDAANHSIPDLQRAAVTILDSISEQSLRLVDAMVYTSNLLTNSVIIMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQTSQWLSNLL TTVEKLRPIF WIEAKLSAGVEFLKDAWEILKFLITGVFDIV
Sbjct 601 VTGGLVQQTSQWLSNLLDTTVEKLRPIFAWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDNIKDCVKCF+DVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNIKDCVKCFVDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIK EQYCALSPGLLATNNVFRLKGGAP KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLEIKANEQYCALSPGLLATNNVFRLKGGAPTKGVTFGEDTVVEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDE-TCEHEYGTEDDYQG 959
WSVATFYLFDD+GEE SSRMYCSFYPPDEEE+ + EEEE+ E TCEHEYGTE+DY+G
Sbjct 901 WSVATFYLFDDSGEEKLSSRMYCSFYPPDEEEDCEEYEEEEEVSERTCEHEYGTEEDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS + ++VEE+EEEDWLDD E EPEPEP EEPVNQ TGYLKLTDNVAIK
Sbjct 961 LPLEFGASTDIIQVEEQEEEDWLDD---AVEAEPEPEPLHEEPVNQLTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIV+EAQ+ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD YIKLNGPLTVGG
Sbjct 1018 CVDIVEEAQNANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDHYIKLNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
LQ+CVQTVRTQVYI VNDK LYEQVVMDYLD+LKP+VEAPKQE P E K +EKSVVQ
Sbjct 1138 LQMCVQTVRTQVYIVVNDKVLYEQVVMDYLDSLKPKVEAPKQEVLPKAEYPKVDEKSVVQ 1197
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
K +DVKPKIKACIDEVTTTLEETKFLTNKLLLF DINGKLY DS+NMLRGEDMSFLEKDA
Sbjct 1198 KTIDVKPKIKACIDEVTTTLEETKFLTNKLLLFTDINGKLYQDSKNMLRGEDMSFLEKDA 1257
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVP++EYITTYPGQGCAGYTLEEAK
Sbjct 1258 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPINEYITTYPGQGCAGYTLEEAK 1317
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PNAKEEILGTVSWNLREMLAHAEETRKLMP+CMDVRAIMATIQ
Sbjct 1318 TALKKCKSAFYVLPSETPNAKEEILGTVSWNLREMLAHAEETRKLMPVCMDVRAIMATIQ 1377
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA
Sbjct 1378 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1437
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPA+VSVSSPDAVTTYNGYLTSSSKTSE+HFVETVSLAGSYRDWSYSGQRTEL
Sbjct 1438 RCMRSLKAPAIVSVSSPDAVTTYNGYLTSSSKTSEDHFVETVSLAGSYRDWSYSGQRTEL 1497
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRG+KIVYHTLESPV+FHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHTQ
Sbjct 1498 GVEFLKRGEKIVYHTLESPVKFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1557
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
LVDMSMTYGQQ GPTYL+GADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF
Sbjct 1558 LVDMSMTYGQQLGPTYLEGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1617
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1618 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQIEVKFNAPALQEAYYRA 1677
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1678 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1737
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
TGVEAVMYMGTLSYDNLK GVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL
Sbjct 1738 TGVEAVMYMGTLSYDNLKMGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1797
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY
Sbjct 1798 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1857
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL+PTQPLPNASFDNFKLTCSNTKFADDLN
Sbjct 1858 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLIPTQPLPNASFDNFKLTCSNTKFADDLN 1917
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT
Sbjct 1918 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1977
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT EEVVENPTIQKEVI
Sbjct 1978 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTPEEVVENPTIQKEVI 2037
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPSDEGVKVTQEL HEDLMAAYVENTSITIKKPNELSLALGLKTI
Sbjct 2038 ECDVKTTEVVGNVILKPSDEGVKVTQELDHEDLMAAYVENTSITIKKPNELSLALGLKTI 2097
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHGIAAINSVPW KILAYVKPFLGQAA+TTSNCAKRL QR+FNNYMPYV TLLFQLCTF
Sbjct 2098 ATHGIAAINSVPWGKILAYVKPFLGQAAVTTSNCAKRLVQRMFNNYMPYVLTLLFQLCTF 2157
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRIRASLPTTIAKNSV+ + +LCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS
Sbjct 2158 TKSTNSRIRASLPTTIAKNSVRGIVRLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2217
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
LI VTAA GVLLSNFGAPSYC+GVRE YLNSSNVTTMDFCEGSFPCS+CLSGLDSLDSYP
Sbjct 2218 LIYVTAALGVLLSNFGAPSYCSGVRESYLNSSNVTTMDFCEGSFPCSVCLSGLDSLDSYP 2277
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLTILGLAAEW AYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS
Sbjct 2278 ALETIQVTISSYKLDLTILGLAAEWFFAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2337
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2338 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2397
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2398 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2457
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2458 PTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2517
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2518 FDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2577
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSA+RQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2578 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSASRQGVVDTDVDTKDVIECLKLSHHSD 2637
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVA+SHNVSLIWNVKDYMSLS
Sbjct 2638 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVARSHNVSLIWNVKDYMSLS 2697
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVST FK+MLKATLLCVL
Sbjct 2698 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTWFKIMLKATLLCVL 2757
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AALVCYIVMPVH LS+H GYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2758 AALVCYIVMPVHILSVHGGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2817
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2818 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2877
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDF+TSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2878 IEYSDFSTSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2937
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPN YLEGSVRVVTTFDAEYCRHGTCERSE GICLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2938 QFPNAYLEGSVRVVTTFDAEYCRHGTCERSEAGICLSTSGRWVLNNEHYRALPGVFCGVD 2997
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2998 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3057
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LFLMSFTILCL PAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3058 PLFLMSFTILCLAPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3117
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFFNNYLRKRV+FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT
Sbjct 3118 IYVFCISLKHFHWFFNNYLRKRVVFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3177
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3178 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3237
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI
Sbjct 3238 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3297
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3298 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3357
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT VHAGTDLEG
Sbjct 3358 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTEVHAGTDLEG 3417
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3418 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3477
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3478 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3537
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFK+IVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA+A
Sbjct 3538 CSGVTFQGKFKRIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAVA 3597
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3598 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3657
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS
Sbjct 3658 VMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3717
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3718 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3777
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3778 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3837
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3838 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3897
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK
Sbjct 3898 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3957
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFDR+AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3958 SLNVAKSEFDRNAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4017
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4018 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4077
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINM+NS NLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4078 DADSKIVQLSEINMENSSNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4137
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4138 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4197
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYL+FIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4198 PKVKYLHFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4257
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4258 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4317
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLN
Sbjct 4318 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLN 4376
>sp|P0C6F8|R1A_BCHK3 Replicase polyprotein 1a OS=Bat coronavirus
HKU3 OX=442736 GN=1a PE=3 SV=1
Length=4376
Score = 6302 bits (16350), Expect = 0.0, Method: Composition-based stats.
Identities = 4117/4383 (94%), Positives = 4255/4383 (97%), Gaps = 8/4383 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAE+DGIQ+GRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAELDGIQFGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
VTRYVDNNFCGPDGYPL+CIKDFLARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 VVTRYVDNNFCGPDGYPLECIKDFLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVF+YVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFSYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITG+NVETLNEDLLEIL+RERVNINIVGDF NEEVAIILASF
Sbjct 421 AYWVPRASANIGANHTGITGENVETLNEDLLEILNRERVNINIVGDFRFNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAS SAFI+T+K LDYKSFK IVESCGNYKVT GKPV GAWNIGQQRS+LTPLCGFPSQA
Sbjct 481 SASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGKPVTGAWNIGQQRSILTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSI DLQRAAVT LDGISEQSLRLVDAMVYTSDLLTNSV++MAY
Sbjct 541 AGVIRSIFSRTLDAANHSILDLQRAAVTTLDGISEQSLRLVDAMVYTSDLLTNSVVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQT QWLSN+LGT V+KL+P+F W+EAKLSAGVEFL+DAWEILKFLITGVFD++
Sbjct 601 VTGGLVQQTMQWLSNMLGTAVDKLKPVFTWVEAKLSAGVEFLRDAWEILKFLITGVFDVI 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVA+DNIK+CVK F+ VVNKALEMC+DQVTIAG KLR+LNLGEVFIAQS+GLYRQC
Sbjct 661 KGQIQVATDNIKECVKIFLGVVNKALEMCLDQVTIAGTKLRALNLGEVFIAQSRGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGD+HDTVLTSEEVVLK+GELEALETP+DSFT+GA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVLKSGELEALETPIDSFTSGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLE+++KEQYCALSPGLLATNNVFRLKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLELENKEQYCALSPGLLATNNVFRLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELD RVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLT MGIDLDE
Sbjct 841 KITFELDVRVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTPMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEE TCEHEYGTEDDY+GL
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEECEDEEE---TCEHEYGTEDDYKGL 957
Query 961 PLEFGASAETVRVEEEEEE-DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
PLEFGAS ET VEEEEEE DWLDD E PVNQF GYLKLTDNVAIK
Sbjct 958 PLEFGASTETPHVEEEEEEEDWLDDAIEAEPEPEPLPEE---PVNQFVGYLKLTDNVAIK 1014
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
C+DIVKEAQSA P VIVNAAN HLKHGGGVAGALNKATNGAMQ ESD+YI+ NGPLTVGG
Sbjct 1015 CIDIVKEAQSAKPTVIVNAANTHLKHGGGVAGALNKATNGAMQNESDEYIRQNGPLTVGG 1074
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLA+KCLHVVGPNLNAGED+QLLK AYENFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1075 SCLLSGHNLAEKCLHVVGPNLNAGEDVQLLKRAYENFNSQDVLLAPLLSAGIFGAKPLQS 1134
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
L++CV+ VRTQVY+AVNDK+LY+Q+V+DYLD+LKP+VE+P +EE P E+ K + V +
Sbjct 1135 LKMCVEIVRTQVYLAVNDKSLYDQIVLDYLDSLKPKVESPNKEEEPKLEEPKA-VQPVAE 1193
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLY DSQNMLRGEDMSFLEKDA
Sbjct 1194 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYQDSQNMLRGEDMSFLEKDA 1253
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PY+VGDVITSGDITCV+IP+KK+GGTTEML+RALK+VPV EYITTYPGQGCAGYTLEEAK
Sbjct 1254 PYIVGDVITSGDITCVIIPAKKSGGTTEMLARALKEVPVAEYITTYPGQGCAGYTLEEAK 1313
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PN KEE+LGTVSWNLREMLAHAEETRKLMPIC+DVRAIMATIQ
Sbjct 1314 TALKKCKSAFYVLPSETPNEKEEVLGTVSWNLREMLAHAEETRKLMPICLDVRAIMATIQ 1373
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHG NLEEAA
Sbjct 1374 RKYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGLNLEEAA 1433
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPAVVSVSSPDAVT YNGYLTSSSKT EE+FVET SLAGSYRDWSYSGQRTEL
Sbjct 1434 RCMRSLKAPAVVSVSSPDAVTAYNGYLTSSSKTPEEYFVETTSLAGSYRDWSYSGQRTEL 1493
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRGDKIVYHT SP+EFHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHT
Sbjct 1494 GVEFLKRGDKIVYHTTGSPIEFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTH 1553
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
+VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHT+DESF
Sbjct 1554 IVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTIDESF 1613
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1614 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQVEVKFNAPALQEAYYRA 1673
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1674 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1733
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
GVEAVMYMGTLSYD LKTGVSIPCVCGR+ATQYLVQQESSFVMMSAPPAEYKLQQG FL
Sbjct 1734 KGVEAVMYMGTLSYDELKTGVSIPCVCGRNATQYLVQQESSFVMMSAPPAEYKLQQGAFL 1793
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYR+DGAHLTKMSEYKGPVTDVFYKETSYTT IKPVSY
Sbjct 1794 CANEYTGNYQCGHYTHITAKETLYRVDGAHLTKMSEYKGPVTDVFYKETSYTTAIKPVSY 1853
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKK NAYYTEQPIDLVPTQP+PNASFDNFKLTCSNTKFADDLN
Sbjct 1854 KLDGVTYTEIEPKLDGYYKKGNAYYTEQPIDLVPTQPMPNASFDNFKLTCSNTKFADDLN 1913
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGF KPASREL+VTFFPDLNGDVVAIDYRHYS SFKKGAKL+HKPI+WHINQ T KTT
Sbjct 1914 QMTGFKKPASRELTVTFFPDLNGDVVAIDYRHYSTSFKKGAKLVHKPILWHINQTTNKTT 1973
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
+KPN WCLRCLWSTKPVDTSNSFEVL VEDTQGMDNLACESQ TSEEVVENPT+QKE+I
Sbjct 1974 YKPNIWCLRCLWSTKPVDTSNSFEVLVVEDTQGMDNLACESQTTTSEEVVENPTVQKEII 2033
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNELSLALGLKT+
Sbjct 2034 ECDVKTTEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNELSLALGLKTL 2093
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHG AAINSVPWSKILAYVKPFLGQ A+ TSNC K+ QRVF+NYMPYV TLLFQLCTF
Sbjct 2094 ATHGAAAINSVPWSKILAYVKPFLGQTAVITSNCIKKCVQRVFSNYMPYVITLLFQLCTF 2153
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRI+ASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTI MWLLLLSICLGS
Sbjct 2154 TKSTNSRIKASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIVMWLLLLSICLGS 2213
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
L VTA GV LS+ G PSYC+GVRELY+NSSNVTTMDFC+G FPCS+CLSGLDSLDSYP
Sbjct 2214 LTYVTAVLGVCLSSLGVPSYCDGVRELYINSSNVTTMDFCQGYFPCSVCLSGLDSLDSYP 2273
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLT LGLAAEW+LAYMLFTKFFYLLGLSAIMQ FFGYFASHFISNS
Sbjct 2274 ALETIQVTISSYKLDLTFLGLAAEWLLAYMLFTKFFYLLGLSAIMQAFFGYFASHFISNS 2333
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYY+WKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2334 WLMWFIISIVQMAPVSAMVRMYIFFASFYYVWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2393
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNG+KRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2394 CTTIVNGVKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2453
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQS+Y+VDSV VKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2454 PTDQSAYVVDSVTVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2513
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKC+ESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2514 FDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2573
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2574 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2633
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
+EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSL+WNVKDYMSLS
Sbjct 2634 IEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLVWNVKDYMSLS 2693
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGK+VST FKL+LK TLLCVL
Sbjct 2694 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKVVSTWFKLLLKVTLLCVL 2753
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AAL CY++MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2754 AALFCYVIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2813
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSY+NDK+CPVVAAIITREIGFIVPGLPGTVLRA+NGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2814 GSYRNDKNCPVVAAIITREIGFIVPGLPGTVLRALNGDFLHFLPRVFSAVGNICYTPSKL 2873
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2874 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2933
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVG+CLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2934 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVD 2993
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2994 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3053
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3054 LLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3113
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFF+NYL+KRVMFNGVTFSTFEEAALCTFLLNKEMYL+LRSETLLPLT
Sbjct 3114 IYVFCISLKHFHWFFSNYLKKRVMFNGVTFSTFEEAALCTFLLNKEMYLRLRSETLLPLT 3173
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3174 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3233
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV+CTAEDMLNPNY+DLLI
Sbjct 3234 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVVCTAEDMLNPNYDDLLI 3293
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3294 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3353
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG
Sbjct 3354 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3413
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3414 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3473
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3474 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3533
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPF LGIMA+A
Sbjct 3534 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFALGIMAVA 3593
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3594 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3653
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAISMWALVISVTS
Sbjct 3654 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAISMWALVISVTS 3713
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3714 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3773
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3774 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3833
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3834 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3893
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV+NGDSEVVLKKLKK
Sbjct 3894 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVSNGDSEVVLKKLKK 3953
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFD DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3954 SLNVAKSEFDHDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4013
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4014 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4073
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4074 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4133
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNN+KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4134 CTDDNALAYYNNAKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4193
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4194 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4253
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4254 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4313
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNG 4379
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLNG
Sbjct 4314 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLNG 4373
Query 4380 FAV 4382
FAV
Sbjct 4374 FAV 4376
>sp|P0C6W2|R1AB_BCHK3 Replicase polyprotein 1ab OS=Bat coronavirus
HKU3 OX=442736 GN=rep PE=3 SV=1
Length=7067
Score = 6299 bits (16341), Expect = 0.0, Method: Composition-based stats.
Identities = 4113/4379 (94%), Positives = 4251/4379 (97%), Gaps = 8/4379 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
Sbjct 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDALSTNHGHKVVELVAE+DGIQ+GRSGITLGVLVPHVGETPIAYRN
Sbjct 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAELDGIQFGRSGITLGVLVPHVGETPIAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHS+GIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
Sbjct 121 VLLRKNGNKGAGGHSFGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
VTRYVDNNFCGPDGYPL+CIKDFLARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 VVTRYVDNNFCGPDGYPLECIKDFLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
PTNAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVF+YVGCYNKR
Sbjct 361 PTNAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFSYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITG+NVETLNEDLLEIL+RERVNINIVGDF NEEVAIILASF
Sbjct 421 AYWVPRASANIGANHTGITGENVETLNEDLLEILNRERVNINIVGDFRFNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAS SAFI+T+K LDYKSFK IVESCGNYKVT GKPV GAWNIGQQRS+LTPLCGFPSQA
Sbjct 481 SASPSAFIETVKGLDYKSFKVIVESCGNYKVTNGKPVTGAWNIGQQRSILTPLCGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF+RTLDAANHSI DLQRAAVT LDGISEQSLRLVDAMVYTSDLLTNSV++MAY
Sbjct 541 AGVIRSIFSRTLDAANHSILDLQRAAVTTLDGISEQSLRLVDAMVYTSDLLTNSVVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQT QWLSN+LGT V+KL+P+F W+EAKLSAGVEFL+DAWEILKFLITGVFD++
Sbjct 601 VTGGLVQQTMQWLSNMLGTAVDKLKPVFTWVEAKLSAGVEFLRDAWEILKFLITGVFDVI 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVA+DNIK+CVK F+ VVNKALEMC+DQVTIAG KLR+LNLGEVFIAQS+GLYRQC
Sbjct 661 KGQIQVATDNIKECVKIFLGVVNKALEMCLDQVTIAGTKLRALNLGEVFIAQSRGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPLKAPKEVTFLEGD+HDTVLTSEEVVLK+GELEALETP+DSFT+GA+VG
Sbjct 721 IRGKEQLQLLMPLKAPKEVTFLEGDAHDTVLTSEEVVLKSGELEALETPIDSFTSGAVVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLE+++KEQYCALSPGLLATNNVFRLKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCINGLMLLELENKEQYCALSPGLLATNNVFRLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELD RVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLT MGIDLDE
Sbjct 841 KITFELDVRVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTPMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEE TCEHEYGTEDDY+GL
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEECEDEEE---TCEHEYGTEDDYKGL 957
Query 961 PLEFGASAETVRVEEEEEE-DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
PLEFGAS ET VEEEEEE DWLDD E PVNQF GYLKLTDNVAIK
Sbjct 958 PLEFGASTETPHVEEEEEEEDWLDDAIEAEPEPEPLPEE---PVNQFVGYLKLTDNVAIK 1014
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
C+DIVKEAQSA P VIVNAAN HLKHGGGVAGALNKATNGAMQ ESD+YI+ NGPLTVGG
Sbjct 1015 CIDIVKEAQSAKPTVIVNAANTHLKHGGGVAGALNKATNGAMQNESDEYIRQNGPLTVGG 1074
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLA+KCLHVVGPNLNAGED+QLLK AYENFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1075 SCLLSGHNLAEKCLHVVGPNLNAGEDVQLLKRAYENFNSQDVLLAPLLSAGIFGAKPLQS 1134
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQ 1199
L++CV+ VRTQVY+AVNDK+LY+Q+V+DYLD+LKP+VE+P +EE P E+ K + V +
Sbjct 1135 LKMCVEIVRTQVYLAVNDKSLYDQIVLDYLDSLKPKVESPNKEEEPKLEEPKA-VQPVAE 1193
Query 1200 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDA 1259
KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLY DSQNMLRGEDMSFLEKDA
Sbjct 1194 KPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYQDSQNMLRGEDMSFLEKDA 1253
Query 1260 PYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAK 1319
PY+VGDVITSGDITCV+IP+KK+GGTTEML+RALK+VPV EYITTYPGQGCAGYTLEEAK
Sbjct 1254 PYIVGDVITSGDITCVIIPAKKSGGTTEMLARALKEVPVAEYITTYPGQGCAGYTLEEAK 1313
Query 1320 TALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQ 1379
TALKKCKSAFYVLPSE PN KEE+LGTVSWNLREMLAHAEETRKLMPIC+DVRAIMATIQ
Sbjct 1314 TALKKCKSAFYVLPSETPNEKEEVLGTVSWNLREMLAHAEETRKLMPICLDVRAIMATIQ 1373
Query 1380 RKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAA 1439
RKYKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHG NLEEAA
Sbjct 1374 RKYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGLNLEEAA 1433
Query 1440 RCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTEL 1499
RCMRSLKAPAVVSVSSPDAVT YNGYLTSSSKT EE+FVET SLAGSYRDWSYSGQRTEL
Sbjct 1434 RCMRSLKAPAVVSVSSPDAVTAYNGYLTSSSKTPEEYFVETTSLAGSYRDWSYSGQRTEL 1493
Query 1500 GVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQ 1559
GVEFLKRGDKIVYHT SP+EFHLDGEVL LDKLKSLLSLREVKTIKVFTTVDNTNLHT
Sbjct 1494 GVEFLKRGDKIVYHTTGSPIEFHLDGEVLPLDKLKSLLSLREVKTIKVFTTVDNTNLHTH 1553
Query 1560 LVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF 1619
+VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHT+DESF
Sbjct 1554 IVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTIDESF 1613
Query 1620 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRA 1679
LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ+EVKFNAPALQEAYYRA
Sbjct 1614 LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQVEVKFNAPALQEAYYRA 1673
Query 1680 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1739
RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL
Sbjct 1674 RAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL 1733
Query 1740 TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFL 1799
GVEAVMYMGTLSYD LKTGVSIPCVCGR+ATQYLVQQESSFVMMSAPPAEYKLQQG FL
Sbjct 1734 KGVEAVMYMGTLSYDELKTGVSIPCVCGRNATQYLVQQESSFVMMSAPPAEYKLQQGAFL 1793
Query 1800 CANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSY 1859
CANEYTGNYQCGHYTHITAKETLYR+DGAHLTKMSEYKGPVTDVFYKETSYTT IKPVSY
Sbjct 1794 CANEYTGNYQCGHYTHITAKETLYRVDGAHLTKMSEYKGPVTDVFYKETSYTTAIKPVSY 1853
Query 1860 KLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLN 1919
KLDGVTYTEIEPKLDGYYKK NAYYTEQPIDLVPTQP+PNASFDNFKLTCSNTKFADDLN
Sbjct 1854 KLDGVTYTEIEPKLDGYYKKGNAYYTEQPIDLVPTQPMPNASFDNFKLTCSNTKFADDLN 1913
Query 1920 QMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTT 1979
QMTGF KPASREL+VTFFPDLNGDVVAIDYRHYS SFKKGAKL+HKPI+WHINQ T KTT
Sbjct 1914 QMTGFKKPASRELTVTFFPDLNGDVVAIDYRHYSTSFKKGAKLVHKPILWHINQTTNKTT 1973
Query 1980 FKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVI 2039
+KPN WCLRCLWSTKPVDTSNSFEVL VEDTQGMDNLACESQ TSEEVVENPT+QKE+I
Sbjct 1974 YKPNIWCLRCLWSTKPVDTSNSFEVLVVEDTQGMDNLACESQTTTSEEVVENPTVQKEII 2033
Query 2040 ECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTI 2099
ECDVKTTEVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNELSLALGLKT+
Sbjct 2034 ECDVKTTEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNELSLALGLKTL 2093
Query 2100 ATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTF 2159
ATHG AAINSVPWSKILAYVKPFLGQ A+ TSNC K+ QRVF+NYMPYV TLLFQLCTF
Sbjct 2094 ATHGAAAINSVPWSKILAYVKPFLGQTAVITSNCIKKCVQRVFSNYMPYVITLLFQLCTF 2153
Query 2160 TKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGS 2219
TKSTNSRI+ASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTI MWLLLLSICLGS
Sbjct 2154 TKSTNSRIKASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIVMWLLLLSICLGS 2213
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYP 2279
L VTA GV LS+ G PSYC+GVRELY+NSSNVTTMDFC+G FPCS+CLSGLDSLDSYP
Sbjct 2214 LTYVTAVLGVCLSSLGVPSYCDGVRELYINSSNVTTMDFCQGYFPCSVCLSGLDSLDSYP 2273
Query 2280 ALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS 2339
ALETIQVTISSYKLDLT LGLAAEW+LAYMLFTKFFYLLGLSAIMQ FFGYFASHFISNS
Sbjct 2274 ALETIQVTISSYKLDLTFLGLAAEWLLAYMLFTKFFYLLGLSAIMQAFFGYFASHFISNS 2333
Query 2340 WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2399
WLMWFIISIVQMAPVSAMVRMYIFFASFYY+WKSYVHIMDGCTSSTCMMCYKRNRATRVE
Sbjct 2334 WLMWFIISIVQMAPVSAMVRMYIFFASFYYVWKSYVHIMDGCTSSTCMMCYKRNRATRVE 2393
Query 2400 CTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPIN 2459
CTTIVNG+KRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARDLSLQFKRPIN
Sbjct 2394 CTTIVNGVKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARDLSLQFKRPIN 2453
Query 2460 PTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2519
PTDQS+Y+VDSV VKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV
Sbjct 2454 PTDQSAYVVDSVTVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIV 2513
Query 2520 FDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2579
FDGKSKC+ESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF
Sbjct 2514 FDGKSKCEESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATF 2573
Query 2580 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2639
SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD
Sbjct 2574 SVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSD 2633
Query 2640 LEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLS 2699
+EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSL+WNVKDYMSLS
Sbjct 2634 IEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLVWNVKDYMSLS 2693
Query 2700 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVL 2759
EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGK+VST FKL+LK TLLCVL
Sbjct 2694 EQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKVVSTWFKLLLKVTLLCVL 2753
Query 2760 AALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRG 2819
AAL CY++MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI+STDDCFANKHAGFD+WFSQRG
Sbjct 2754 AALFCYVIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIVSTDDCFANKHAGFDSWFSQRG 2813
Query 2820 GSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
GSY+NDK+CPVVAAIITREIGFIVPGLPGTVLRA+NGDFLHFLPRVFSAVGNICYTPSKL
Sbjct 2814 GSYRNDKNCPVVAAIITREIGFIVPGLPGTVLRALNGDFLHFLPRVFSAVGNICYTPSKL 2873
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2939
IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII
Sbjct 2874 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSII 2933
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVG+CLSTSGRWVLNNEHYRAL GVFCGVD
Sbjct 2934 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGVCLSTSGRWVLNNEHYRALPGVFCGVD 2993
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FGEYNHVVAANA
Sbjct 2994 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFGEYNHVVAANA 3053
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
LLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA
Sbjct 3054 LLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3113
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
IYVFCISLKH HWFF+NYL+KRVMFNGVTFSTFEEAALCTFLLNKEMYL+LRSETLLPLT
Sbjct 3114 IYVFCISLKHFHWFFSNYLKKRVMFNGVTFSTFEEAALCTFLLNKEMYLRLRSETLLPLT 3173
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3239
QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL
Sbjct 3174 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVL 3233
Query 3240 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLI 3299
QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV+CTAEDMLNPNY+DLLI
Sbjct 3234 QSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVVCTAEDMLNPNYDDLLI 3293
Query 3300 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3359
RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN
Sbjct 3294 RKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYN 3353
Query 3360 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3419
GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG
Sbjct 3354 GSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEG 3413
Query 3420 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3479
KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY
Sbjct 3414 KFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNY 3473
Query 3480 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3539
EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ
Sbjct 3474 EPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQ 3533
Query 3540 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIA 3599
CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPF LGIMA+A
Sbjct 3534 CSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFALGIMAVA 3593
Query 3600 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3659
ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC
Sbjct 3594 ACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDC 3653
Query 3660 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTS 3719
VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAISMWALVISVTS
Sbjct 3654 VMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAISMWALVISVTS 3713
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR
Sbjct 3714 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3773
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM
Sbjct 3774 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3833
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ
Sbjct 3834 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3893
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
GAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV+NGDSEVVLKKLKK
Sbjct 3894 GAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVSNGDSEVVLKKLKK 3953
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
SLNVAKSEFD DAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN
Sbjct 3954 SLNVAKSEFDHDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4013
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV
Sbjct 4014 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4073
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA
Sbjct 4074 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4133
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
CTDDNALAYYNN+KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG
Sbjct 4134 CTDDNALAYYNNAKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4193
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD
Sbjct 4194 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4253
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF
Sbjct 4254 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4313
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP+MQSADASTFLN
Sbjct 4314 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPMMQSADASTFLN 4372
>sp|P0C6F5|R1A_BC279 Replicase polyprotein 1a OS=Bat coronavirus
279/2005 OX=389167 GN=1a PE=3 SV=1
Length=4388
Score = 6295 bits (16332), Expect = 0.0, Method: Composition-based stats.
Identities = 4096/4393 (93%), Positives = 4238/4393 (96%), Gaps = 16/4393 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESL LGV+EKTHVQLSLPVLQVRDVLVRGFGDSVEEAL+EAREHLKNGTCGLVELEKGV
Sbjct 1 MESLALGVSEKTHVQLSLPVLQVRDVLVRGFGDSVEEALAEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA TNHG+KVVELVAE+DGIQYGRSG TLGVLVPHVGETP+AYRN
Sbjct 61 LPQLEQPYVFIKRSDAQGTNHGYKVVELVAELDGIQYGRSGTTLGVLVPHVGETPVAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLG ELGTDPIEDYEQNWNTKHG G LREL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGVELGTDPIEDYEQNWNTKHGGGVLRELIRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 AFTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYE QTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYERQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVFAYVGCYNKR
Sbjct 361 PANAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITGDNVETLNEDL+EIL+R+RVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASANIGASHTGITGDNVETLNEDLMEILNRDRVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAST AF+DT+K LDYK+FK IVESCGN+KVT+G+ KGAWNIGQ++S+LTPL GFPSQA
Sbjct 481 SASTCAFVDTVKGLDYKTFKDIVESCGNFKVTRGRAKKGAWNIGQEKSILTPLYGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF R LD ANHSIPDLQRAA+TILDGISEQSLRL+DAMVYTSDLLTNSVI+MAY
Sbjct 541 AGVIRSIFTRALDTANHSIPDLQRAAITILDGISEQSLRLIDAMVYTSDLLTNSVIVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQ +QWLSN+LGTTV+KL+P+F W+EAKLSAG+EFL+DAWEILKFL+TGVFDIV
Sbjct 601 VTGGLVQQITQWLSNMLGTTVDKLKPVFTWVEAKLSAGIEFLRDAWEILKFLVTGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDN+K+CVK F+DV+NKALEMCIDQV IAGAKLR+LNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNLKECVKAFLDVLNKALEMCIDQVIIAGAKLRTLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPL+APKEVTF EGDSHDTV TSEEVVLKNGELEALETPVDSFTNGA++G
Sbjct 721 IRGKEQLQLLMPLRAPKEVTFFEGDSHDTVFTSEEVVLKNGELEALETPVDSFTNGAVIG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLE+KDKEQYCALSPGLLATNNVF LKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCVNGLMLLELKDKEQYCALSPGLLATNNVFSLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 KITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE-HEYGTEDDYQG 959
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEEI E HEYGTEDDY+G
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEEYEDEEEIPEETCEHEYGTEDDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS E +++ +EE+ D E +PEPEP PEEPVNQFTGYLKLTDNVAIK
Sbjct 961 LPLEFGASTE---IQQVDEEEEEDWLEEAIAAKPEPEPLPEEPVNQFTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIVKEAQ A P VIVNAAN+HLKHGGGVAGALNKATNGAMQ+ESDDYIK NGPLTVGG
Sbjct 1018 CVDIVKEAQHAKPTVIVNAANVHLKHGGGVAGALNKATNGAMQQESDDYIKKNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKC+HVVGPNLNAGED+QLLKAAY NFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCMHVVGPNLNAGEDVQLLKAAYANFNSQDVLLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTE------ 1193
L++CV+TVRTQVY AVND+ LY+ VV+ YLD+LKP+VE P QE E E
Sbjct 1138 LKMCVETVRTQVYFAVNDQDLYDHVVLGYLDSLKPKVETPTQENLELKEQPAVETLTQEN 1197
Query 1194 ----EKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRG 1249
E V++KPVDVK KA I+EV T+LEETKFLT++LLLFADINGKLY DSQNMLRG
Sbjct 1198 LELEELPVIEKPVDVK--FKARIEEVNTSLEETKFLTSRLLLFADINGKLYQDSQNMLRG 1255
Query 1250 EDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQG 1309
EDM FLEKDAPY+VGDVI+SGDITCV+IP+KKAGGTTEML++ALKKVPV EYITTYPGQG
Sbjct 1256 EDMFFLEKDAPYIVGDVISSGDITCVIIPAKKAGGTTEMLAKALKKVPVSEYITTYPGQG 1315
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICM 1369
CAGYTLEEAKTAL+KCKS FYVLPS+ PN KEEILGTVSWNLREMLAHAEETRKLM ICM
Sbjct 1316 CAGYTLEEAKTALRKCKSVFYVLPSKTPNDKEEILGTVSWNLREMLAHAEETRKLMLICM 1375
Query 1370 DVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYV 1429
DV+A+M+TI R+YKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLN LNEPLVTMPIGYV
Sbjct 1376 DVKALMSTIHRRYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNLLNEPLVTMPIGYV 1435
Query 1430 THGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRD 1489
THG NLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF+ETVSLAG YRD
Sbjct 1436 THGLNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFIETVSLAGMYRD 1495
Query 1490 WSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFT 1549
WSYSGQRTELGVEFLKRGDK+VYHT+ SP++FHLDGEVL LDKLKSLLSLREV+TIKVFT
Sbjct 1496 WSYSGQRTELGVEFLKRGDKVVYHTVGSPIQFHLDGEVLLLDKLKSLLSLREVRTIKVFT 1555
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF 1609
TVDNTNLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH HEGKTFFVLPSDDTLRSEAF
Sbjct 1556 TVDNTNLHTQIVDMSMTYGQQFGPTYLDGADVTKIKPHAKHEGKTFFVLPSDDTLRSEAF 1615
Query 1610 EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNA 1669
EYYHTLDESFLGRYMSALNHTKKWKFPQ+GGLTSIKWADNNCYLSSVLLALQQ+EVKFNA
Sbjct 1616 EYYHTLDESFLGRYMSALNHTKKWKFPQIGGLTSIKWADNNCYLSSVLLALQQIEVKFNA 1675
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1729
PALQEAYYRARAGDAANFCALILAYSN+TVGELGDVRETMTHLLQHANLESAKRVLNVVC
Sbjct 1676 PALQEAYYRARAGDAANFCALILAYSNRTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1735
Query 1730 KHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA 1789
K CGQK+TTLTGVEAVMYMGTLSY+ LKTGV+IPC+CGRDATQYLVQQESSFVMMSAPP+
Sbjct 1736 KTCGQKSTTLTGVEAVMYMGTLSYEELKTGVTIPCICGRDATQYLVQQESSFVMMSAPPS 1795
Query 1790 EYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
EY LQQG FLCANEYTG+YQCGHYTH+T KETLYRIDGA+LTKMSEYKGPVTDVFYKE S
Sbjct 1796 EYTLQQGAFLCANEYTGSYQCGHYTHVTVKETLYRIDGAYLTKMSEYKGPVTDVFYKEIS 1855
Query 1850 YTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1909
YTTTIKPVSYKLDGV YTEI+PKLD YYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC
Sbjct 1856 YTTTIKPVSYKLDGVIYTEIQPKLDEYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1915
Query 1910 SNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW 1969
SNTKFADDLNQMTGF KPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPI+W
Sbjct 1916 SNTKFADDLNQMTGFKKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW 1975
Query 1970 HINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVV 2029
HINQ T KTT+KPNTWCLRCLWSTKPV+TSNSFEVL VEDTQGMDNLACESQ PTSEEVV
Sbjct 1976 HINQTTNKTTYKPNTWCLRCLWSTKPVETSNSFEVLEVEDTQGMDNLACESQTPTSEEVV 2035
Query 2030 ENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
ENPTIQKEVIECDVKT EVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNE
Sbjct 2036 ENPTIQKEVIECDVKTIEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNE 2095
Query 2090 LSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYV 2149
LSLALGL+T+ATHG AAINSVPWSKILAYVKPFLGQAA+TT+NC KR QRVFNNYMPYV
Sbjct 2096 LSLALGLRTLATHGAAAINSVPWSKILAYVKPFLGQAAVTTTNCIKRCVQRVFNNYMPYV 2155
Query 2150 FTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMW 2209
TLLFQLCTFT+STNSRIRASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTIAMW
Sbjct 2156 ITLLFQLCTFTRSTNSRIRASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIAMW 2215
Query 2210 LLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICL 2269
LLLLSICLGSLI VTAAFGVLLSN G PSYC+GVRE Y+NSSNVTTMDFCEGSF CS+CL
Sbjct 2216 LLLLSICLGSLIYVTAAFGVLLSNLGIPSYCDGVRESYVNSSNVTTMDFCEGSFLCSVCL 2275
Query 2270 SGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFG 2329
+GLDSLDSYPALETIQVTISSYKLDLT LGLAAEW LAYMLFTKFFYLLGLSAIMQVFFG
Sbjct 2276 NGLDSLDSYPALETIQVTISSYKLDLTSLGLAAEWFLAYMLFTKFFYLLGLSAIMQVFFG 2335
Query 2330 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMC 2389
YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFA YY+WKSYVHIMDGCTSSTCMMC
Sbjct 2336 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFAFCYYVWKSYVHIMDGCTSSTCMMC 2395
Query 2390 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARD 2449
YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARD
Sbjct 2396 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARD 2455
Query 2450 LSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2509
LSLQFKRPINPTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT
Sbjct 2456 LSLQFKRPINPTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2515
Query 2510 KGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2569
KGSLPINVIVFDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD
Sbjct 2516 KGSLPINVIVFDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2575
Query 2570 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2629
AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI
Sbjct 2576 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2635
Query 2630 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2689
ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI
Sbjct 2636 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2695
Query 2690 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKL 2749
WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN ITTKISLKGGKIVST FKL
Sbjct 2696 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNAITTKISLKGGKIVSTWFKL 2755
Query 2750 MLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
MLKATLLCVLAAL CYI+MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI++TDDCFANKHA
Sbjct 2756 MLKATLLCVLAALFCYIIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIMATDDCFANKHA 2815
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
GFD+WFSQRGGSY+NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV
Sbjct 2816 GFDSWFSQRGGSYRNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2875
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT
Sbjct 2876 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2935
Query 2930 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYR 2989
RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE G+CLSTSGRWVLNNEHYR
Sbjct 2936 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEAGVCLSTSGRWVLNNEHYR 2995
Query 2990 ALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFG 3049
AL GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FG
Sbjct 2996 ALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFG 3055
Query 3050 EYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMF 3109
EYNHVVAANALLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMF
Sbjct 3056 EYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMF 3115
Query 3110 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3169
SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK
Sbjct 3116 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3175
Query 3170 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3229
LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP
Sbjct 3176 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3235
Query 3230 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3289
PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM
Sbjct 3236 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3295
Query 3290 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3349
LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG
Sbjct 3296 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3355
Query 3350 QTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3409
QTFSVLACYNGSPSGVYQCAMRPN+TIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT
Sbjct 3356 QTFSVLACYNGSPSGVYQCAMRPNYTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3415
Query 3410 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3469
GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND
Sbjct 3416 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3475
Query 3470 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3529
FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED
Sbjct 3476 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3535
Query 3530 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3589
EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL
Sbjct 3536 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3595
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT
Sbjct 3596 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3655
Query 3650 SLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAIS 3709
SLSGYRLKDCVMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAIS
Sbjct 3656 SLSGYRLKDCVMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAIS 3715
Query 3710 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3769
MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC
Sbjct 3716 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3775
Query 3770 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3829
YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC
Sbjct 3776 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3835
Query 3830 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3889
IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV
Sbjct 3836 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3895
Query 3890 SLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
SLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD
Sbjct 3896 SLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3955
Query 3950 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM
Sbjct 3956 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4015
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA
Sbjct 4016 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4075
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4129
SALWEIQQVVDADSKIVQLSEINMDNS NLAWPLIVTALRANSAVKLQNNELSPVALRQM
Sbjct 4076 SALWEIQQVVDADSKIVQLSEINMDNSQNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4135
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP
Sbjct 4136 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4195
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAF 4249
CRFVTDTP+GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANS VLSFCAF
Sbjct 4196 CRFVTDTPRGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSAVLSFCAF 4255
Query 4250 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4309
AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC
Sbjct 4256 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4315
Query 4310 HIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ 4369
HIDHPNPKGFCDLKGKYVQIP TCANDPVGFTL+NTVCTVCG WKGYGCSCDQLREP+MQ
Sbjct 4316 HIDHPNPKGFCDLKGKYVQIPATCANDPVGFTLKNTVCTVCGTWKGYGCSCDQLREPMMQ 4375
Query 4370 SADASTFLNGFAV 4382
SADASTFLNGFAV
Sbjct 4376 SADASTFLNGFAV 4388
>sp|P0C6V9|R1AB_BC279 Replicase polyprotein 1ab OS=Bat coronavirus
279/2005 OX=389167 GN=rep PE=3 SV=1
Length=7079
Score = 6286 bits (16309), Expect = 0.0, Method: Composition-based stats.
Identities = 4092/4389 (93%), Positives = 4234/4389 (96%), Gaps = 16/4389 (0%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESL LGV+EKTHVQLSLPVLQVRDVLVRGFGDSVEEAL+EAREHLKNGTCGLVELEKGV
Sbjct 1 MESLALGVSEKTHVQLSLPVLQVRDVLVRGFGDSVEEALAEAREHLKNGTCGLVELEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA TNHG+KVVELVAE+DGIQYGRSG TLGVLVPHVGETP+AYRN
Sbjct 61 LPQLEQPYVFIKRSDAQGTNHGYKVVELVAELDGIQYGRSGTTLGVLVPHVGETPVAYRN 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYGIDLKSYDLG ELGTDPIEDYEQNWNTKHG G LREL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGIDLKSYDLGVELGTDPIEDYEQNWNTKHGGGVLRELIRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGKSMCTLSEQLDYIESKRGVYCCR+HEHEI W
Sbjct 181 AFTRYVDNNFCGPDGYPLECIKDLLARAGKSMCTLSEQLDYIESKRGVYCCREHEHEIVW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
FTERS+KSYE QTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
Sbjct 241 FTERSEKSYERQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVA+PQECN+MHLSTLMKCNHCDEVSWQTCDFLKATCE CGTENLV EGPTTCGYL
Sbjct 301 RSVYPVATPQECNDMHLSTLMKCNHCDEVSWQTCDFLKATCEQCGTENLVCEGPTTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVKMPCPACQDPE+GPEHSVADYHNHSNIETRLRKGGRT+CFGGCVFAYVGCYNKR
Sbjct 361 PANAVVKMPCPACQDPEVGPEHSVADYHNHSNIETRLRKGGRTKCFGGCVFAYVGCYNKR 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG+ HTGITGDNVETLNEDL+EIL+R+RVNINIVGDFHLNEEVAIILASF
Sbjct 421 AYWVPRASANIGASHTGITGDNVETLNEDLMEILNRDRVNINIVGDFHLNEEVAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SAST AF+DT+K LDYK+FK IVESCGN+KVT+G+ KGAWNIGQ++S+LTPL GFPSQA
Sbjct 481 SASTCAFVDTVKGLDYKTFKDIVESCGNFKVTRGRAKKGAWNIGQEKSILTPLYGFPSQA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
AGVIRSIF R LD ANHSIPDLQRAA+TILDGISEQSLRL+DAMVYTSDLLTNSVI+MAY
Sbjct 541 AGVIRSIFTRALDTANHSIPDLQRAAITILDGISEQSLRLIDAMVYTSDLLTNSVIVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
VTGGLVQQ +QWLSN+LGTTV+KL+P+F W+EAKLSAG+EFL+DAWEILKFL+TGVFDIV
Sbjct 601 VTGGLVQQITQWLSNMLGTTVDKLKPVFTWVEAKLSAGIEFLRDAWEILKFLVTGVFDIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
KGQIQVASDN+K+CVK F+DV+NKALEMCIDQV IAGAKLR+LNLGEVFIAQSKGLYRQC
Sbjct 661 KGQIQVASDNLKECVKAFLDVLNKALEMCIDQVIIAGAKLRTLNLGEVFIAQSKGLYRQC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
IRGKEQLQLLMPL+APKEVTF EGDSHDTV TSEEVVLKNGELEALETPVDSFTNGA++G
Sbjct 721 IRGKEQLQLLMPLRAPKEVTFFEGDSHDTVFTSEEVVLKNGELEALETPVDSFTNGAVIG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVCVNGLMLLE+KDKEQYCALSPGLLATNNVF LKGGAP+KGVTFGEDTV EVQGYKNV
Sbjct 781 TPVCVNGLMLLELKDKEQYCALSPGLLATNNVFSLKGGAPVKGVTFGEDTVLEVQGYKNV 840
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
+ITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
Sbjct 841 KITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE-HEYGTEDDYQG 959
WSVATFYLFDDAGEE SSRMYCSFYPPDEEE+ + +EEEI E HEYGTEDDY+G
Sbjct 901 WSVATFYLFDDAGEEKLSSRMYCSFYPPDEEEDCEEYEDEEEIPEETCEHEYGTEDDYKG 960
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
LPLEFGAS E +++ +EE+ D E +PEPEP PEEPVNQFTGYLKLTDNVAIK
Sbjct 961 LPLEFGASTE---IQQVDEEEEEDWLEEAIAAKPEPEPLPEEPVNQFTGYLKLTDNVAIK 1017
Query 1020 CVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGG 1079
CVDIVKEAQ A P VIVNAAN+HLKHGGGVAGALNKATNGAMQ+ESDDYIK NGPLTVGG
Sbjct 1018 CVDIVKEAQHAKPTVIVNAANVHLKHGGGVAGALNKATNGAMQQESDDYIKKNGPLTVGG 1077
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
SCLLSGHNLAKKC+HVVGPNLNAGED+QLLKAAY NFNSQD+LLAPLLSAGIFGAKPLQS
Sbjct 1078 SCLLSGHNLAKKCMHVVGPNLNAGEDVQLLKAAYANFNSQDVLLAPLLSAGIFGAKPLQS 1137
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTE------ 1193
L++CV+TVRTQVY AVND+ LY+ VV+ YLD+LKP+VE P QE E E
Sbjct 1138 LKMCVETVRTQVYFAVNDQDLYDHVVLGYLDSLKPKVETPTQENLELKEQPAVETLTQEN 1197
Query 1194 ----EKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRG 1249
E V++KPVDVK KA I+EV T+LEETKFLT++LLLFADINGKLY DSQNMLRG
Sbjct 1198 LELEELPVIEKPVDVK--FKARIEEVNTSLEETKFLTSRLLLFADINGKLYQDSQNMLRG 1255
Query 1250 EDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQG 1309
EDM FLEKDAPY+VGDVI+SGDITCV+IP+KKAGGTTEML++ALKKVPV EYITTYPGQG
Sbjct 1256 EDMFFLEKDAPYIVGDVISSGDITCVIIPAKKAGGTTEMLAKALKKVPVSEYITTYPGQG 1315
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICM 1369
CAGYTLEEAKTAL+KCKS FYVLPS+ PN KEEILGTVSWNLREMLAHAEETRKLM ICM
Sbjct 1316 CAGYTLEEAKTALRKCKSVFYVLPSKTPNDKEEILGTVSWNLREMLAHAEETRKLMLICM 1375
Query 1370 DVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYV 1429
DV+A+M+TI R+YKGIK+QEGIVDYGVRFFFYTSKEPVASIITKLN LNEPLVTMPIGYV
Sbjct 1376 DVKALMSTIHRRYKGIKVQEGIVDYGVRFFFYTSKEPVASIITKLNLLNEPLVTMPIGYV 1435
Query 1430 THGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRD 1489
THG NLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF+ETVSLAG YRD
Sbjct 1436 THGLNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFIETVSLAGMYRD 1495
Query 1490 WSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFT 1549
WSYSGQRTELGVEFLKRGDK+VYHT+ SP++FHLDGEVL LDKLKSLLSLREV+TIKVFT
Sbjct 1496 WSYSGQRTELGVEFLKRGDKVVYHTVGSPIQFHLDGEVLLLDKLKSLLSLREVRTIKVFT 1555
Query 1550 TVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF 1609
TVDNTNLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH HEGKTFFVLPSDDTLRSEAF
Sbjct 1556 TVDNTNLHTQIVDMSMTYGQQFGPTYLDGADVTKIKPHAKHEGKTFFVLPSDDTLRSEAF 1615
Query 1610 EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNA 1669
EYYHTLDESFLGRYMSALNHTKKWKFPQ+GGLTSIKWADNNCYLSSVLLALQQ+EVKFNA
Sbjct 1616 EYYHTLDESFLGRYMSALNHTKKWKFPQIGGLTSIKWADNNCYLSSVLLALQQIEVKFNA 1675
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1729
PALQEAYYRARAGDAANFCALILAYSN+TVGELGDVRETMTHLLQHANLESAKRVLNVVC
Sbjct 1676 PALQEAYYRARAGDAANFCALILAYSNRTVGELGDVRETMTHLLQHANLESAKRVLNVVC 1735
Query 1730 KHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA 1789
K CGQK+TTLTGVEAVMYMGTLSY+ LKTGV+IPC+CGRDATQYLVQQESSFVMMSAPP+
Sbjct 1736 KTCGQKSTTLTGVEAVMYMGTLSYEELKTGVTIPCICGRDATQYLVQQESSFVMMSAPPS 1795
Query 1790 EYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
EY LQQG FLCANEYTG+YQCGHYTH+T KETLYRIDGA+LTKMSEYKGPVTDVFYKE S
Sbjct 1796 EYTLQQGAFLCANEYTGSYQCGHYTHVTVKETLYRIDGAYLTKMSEYKGPVTDVFYKEIS 1855
Query 1850 YTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1909
YTTTIKPVSYKLDGV YTEI+PKLD YYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC
Sbjct 1856 YTTTIKPVSYKLDGVIYTEIQPKLDEYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTC 1915
Query 1910 SNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVW 1969
SNTKFADDLNQMTGF KPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPI+W
Sbjct 1916 SNTKFADDLNQMTGFKKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIIW 1975
Query 1970 HINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVV 2029
HINQ T KTT+KPNTWCLRCLWSTKPV+TSNSFEVL VEDTQGMDNLACESQ PTSEEVV
Sbjct 1976 HINQTTNKTTYKPNTWCLRCLWSTKPVETSNSFEVLEVEDTQGMDNLACESQTPTSEEVV 2035
Query 2030 ENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNE 2089
ENPTIQKEVIECDVKT EVVGNVILKPS+EGVKVTQELGHEDLMAAYVE TSITIKKPNE
Sbjct 2036 ENPTIQKEVIECDVKTIEVVGNVILKPSEEGVKVTQELGHEDLMAAYVEETSITIKKPNE 2095
Query 2090 LSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYV 2149
LSLALGL+T+ATHG AAINSVPWSKILAYVKPFLGQAA+TT+NC KR QRVFNNYMPYV
Sbjct 2096 LSLALGLRTLATHGAAAINSVPWSKILAYVKPFLGQAAVTTTNCIKRCVQRVFNNYMPYV 2155
Query 2150 FTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMW 2209
TLLFQLCTFT+STNSRIRASLPTTIAKNSVKSVAKLCLD INYVKSPKFSKLFTIAMW
Sbjct 2156 ITLLFQLCTFTRSTNSRIRASLPTTIAKNSVKSVAKLCLDVCINYVKSPKFSKLFTIAMW 2215
Query 2210 LLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICL 2269
LLLLSICLGSLI VTAAFGVLLSN G PSYC+GVRE Y+NSSNVTTMDFCEGSF CS+CL
Sbjct 2216 LLLLSICLGSLIYVTAAFGVLLSNLGIPSYCDGVRESYVNSSNVTTMDFCEGSFLCSVCL 2275
Query 2270 SGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFG 2329
+GLDSLDSYPALETIQVTISSYKLDLT LGLAAEW LAYMLFTKFFYLLGLSAIMQVFFG
Sbjct 2276 NGLDSLDSYPALETIQVTISSYKLDLTSLGLAAEWFLAYMLFTKFFYLLGLSAIMQVFFG 2335
Query 2330 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMC 2389
YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFA YY+WKSYVHIMDGCTSSTCMMC
Sbjct 2336 YFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFAFCYYVWKSYVHIMDGCTSSTCMMC 2395
Query 2390 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARD 2449
YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK HNWNCLNCDTFC GSTFISDEVARD
Sbjct 2396 YKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKAHNWNCLNCDTFCAGSTFISDEVARD 2455
Query 2450 LSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2509
LSLQFKRPINPTDQSSY+VDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT
Sbjct 2456 LSLQFKRPINPTDQSSYVVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNT 2515
Query 2510 KGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2569
KGSLPINVIVFDGKSKCDESA+KSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD
Sbjct 2516 KGSLPINVIVFDGKSKCDESAAKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFD 2575
Query 2570 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2629
AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI
Sbjct 2576 AYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVI 2635
Query 2630 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2689
ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI
Sbjct 2636 ECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLI 2695
Query 2690 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKL 2749
WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN ITTKISLKGGKIVST FKL
Sbjct 2696 WNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNAITTKISLKGGKIVSTWFKL 2755
Query 2750 MLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
MLKATLLCVLAAL CYI+MPVH+LS+HDGYTNEIIGYKAIQDGVTRDI++TDDCFANKHA
Sbjct 2756 MLKATLLCVLAALFCYIIMPVHSLSVHDGYTNEIIGYKAIQDGVTRDIMATDDCFANKHA 2815
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
GFD+WFSQRGGSY+NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV
Sbjct 2816 GFDSWFSQRGGSYRNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2875
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT
Sbjct 2876 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2935
Query 2930 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYR 2989
RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE G+CLSTSGRWVLNNEHYR
Sbjct 2936 RYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEAGVCLSTSGRWVLNNEHYR 2995
Query 2990 ALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFG 3049
AL GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR FG
Sbjct 2996 ALPGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRAFG 3055
Query 3050 EYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMF 3109
EYNHVVAANALLFLMSFTILCL PAYSFLPGVYS+FYLYLTFYFTNDVSFLAHLQWFAMF
Sbjct 3056 EYNHVVAANALLFLMSFTILCLAPAYSFLPGVYSIFYLYLTFYFTNDVSFLAHLQWFAMF 3115
Query 3110 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3169
SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK
Sbjct 3116 SPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLK 3175
Query 3170 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3229
LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP
Sbjct 3176 LRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQP 3235
Query 3230 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3289
PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM
Sbjct 3236 PQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDM 3295
Query 3290 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3349
LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG
Sbjct 3296 LNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPG 3355
Query 3350 QTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3409
QTFSVLACYNGSPSGVYQCAMRPN+TIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT
Sbjct 3356 QTFSVLACYNGSPSGVYQCAMRPNYTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPT 3415
Query 3410 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3469
GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND
Sbjct 3416 GVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLND 3475
Query 3470 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3529
FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED
Sbjct 3476 FNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILED 3535
Query 3530 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3589
EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL
Sbjct 3536 EFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFL 3595
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT
Sbjct 3596 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3655
Query 3650 SLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAIS 3709
SLSGYRLKDCVMYASALVLL+LMTARTVYDDAARRVWTLMNVITLVYKVYYGN+LDQAIS
Sbjct 3656 SLSGYRLKDCVMYASALVLLVLMTARTVYDDAARRVWTLMNVITLVYKVYYGNSLDQAIS 3715
Query 3710 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3769
MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC
Sbjct 3716 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3775
Query 3770 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3829
YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC
Sbjct 3776 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3835
Query 3830 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3889
IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV
Sbjct 3836 IKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMV 3895
Query 3890 SLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
SLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD
Sbjct 3896 SLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3955
Query 3950 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM
Sbjct 3956 SEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4015
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA
Sbjct 4016 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4075
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4129
SALWEIQQVVDADSKIVQLSEINMDNS NLAWPLIVTALRANSAVKLQNNELSPVALRQM
Sbjct 4076 SALWEIQQVVDADSKIVQLSEINMDNSQNLAWPLIVTALRANSAVKLQNNELSPVALRQM 4135
Query 4130 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4189
SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP
Sbjct 4136 SCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPP 4195
Query 4190 CRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAF 4249
CRFVTDTP+GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANS VLSFCAF
Sbjct 4196 CRFVTDTPRGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSAVLSFCAF 4255
Query 4250 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4309
AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC
Sbjct 4256 AVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRC 4315
Query 4310 HIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQ 4369
HIDHPNPKGFCDLKGKYVQIP TCANDPVGFTL+NTVCTVCG WKGYGCSCDQLREP+MQ
Sbjct 4316 HIDHPNPKGFCDLKGKYVQIPATCANDPVGFTLKNTVCTVCGTWKGYGCSCDQLREPMMQ 4375
Query 4370 SADASTFLN 4378
SADASTFLN
Sbjct 4376 SADASTFLN 4384
>sp|P0DTC1|R1A_SARS2 Replicase polyprotein 1a OS=Severe acute
respiratory syndrome coronavirus 2 OX=2697049 PE=1 SV=1
Length=4405
Score = 5997 bits (15557), Expect = 0.0, Method: Composition-based stats.
Identities = 3549/4412 (80%), Positives = 3948/4412 (89%), Gaps = 37/4412 (1%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLV G NEKTHVQLSLPVLQVRDVLVRGFGDSVEE LSEAR+HLK+GTCGLVE+EKGV
Sbjct 1 MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA + HGH +VELVAE++GIQYGRSG TLGVLVPHVGE P+AYR
Sbjct 61 LPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRK 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYG DLKS+DLGDELGTDP ED+++NWNTKH SG REL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGK+ CTLSEQLD+I++KRGVYCCR+HEHEIAW
Sbjct 181 AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
+TERS+KSYE QTPFEIK AKKFDTF GECP FVFPLNS +K IQPRVEKKK +GFMGRI
Sbjct 241 YTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASP ECN M LSTLMKC+HC E SWQT DF+KATCE CGTENL EG TTCGYL
Sbjct 301 RSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVK+ CPAC + E+GPEHS+A+YHN S ++T LRKGGRT FGGCVF+YVGC+NK
Sbjct 361 PQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKC 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG HTG+ G+ E LN++LLEIL +E+VNINIVGDF LNEE+AIILASF
Sbjct 421 AYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAF++T+K LDYK+FK IVESCGN+KVTKGK KGAWNIG+Q+S+L+PL F S+A
Sbjct 481 SASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
A V+RSIF+RTL+ A +S+ LQ+AA+TILDGIS+ SLRL+DAM++TSDL TN++++MAY
Sbjct 541 ARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
+TGG+VQ TSQWL+N+ GT EKL+P+ +W+E K GVEFL+D WEI+KF+ T +IV
Sbjct 601 ITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
GQI + IK+ V+ F +VNK L +C D + I GAKL++LNLGE F+ SKGLYR+C
Sbjct 661 GGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
++ +E+ LLMPLKAPKE+ FLEG++ T + +EEVVLK G+L+ LE P +VG
Sbjct 721 VKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIKD E+YCAL+P ++ TNN F LKGGAP K VTFG+DTV EVQGYK+V
Sbjct 781 TPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTK-VTFGDDTVIEVQGYKSV 839
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
ITFELDER+DKVLNEKCS YTVE GTEV EFACVVA+AV+KTLQPVS+LLT +GIDLDE
Sbjct 840 NITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDE 899
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WS+AT+YLFD++GE +S MYCSFYPPDE+EE+ EEE T ++EYGTEDDYQG
Sbjct 900 WSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPST-QYEYGTEDDYQGK 958
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQ-------------------SEIEP--EPEPTP 999
PLEFGA++ ++ EEE+EEDWLDD ++Q E++P E E TP
Sbjct 959 PLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTP 1018
Query 1000 ---EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKA 1056
VN F+GYLKLTDNV IK DIV+EA+ P V+VNAAN++LKHGGGVAGALNKA
Sbjct 1019 VVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKA 1078
Query 1057 TNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
TN AMQ ESDDYI NGPL VGGSC+LSGHNLAK CLHVVGPN+N GEDIQLLK+AYENF
Sbjct 1079 TNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENF 1138
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR- 1175
N ++LLAPLLSAGIFGA P+ SL+VCV TVRT VY+AV DK LY+++V +L+ +
Sbjct 1139 NQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQ 1198
Query 1176 -----VEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL 1230
E PK+E P +SK SV Q+ D K KIKAC++EVTTTLEETKFLT LL
Sbjct 1199 VEQKIAEIPKEEVKPFITESK---PSVEQRKQDDK-KIKACVEEVTTTLEETKFLTENLL 1254
Query 1231 LFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLS 1290
L+ DING L+ DS ++ D++FL+KDAPY+VGDV+ G +T VVIP+KKAGGTTEML+
Sbjct 1255 LYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLA 1314
Query 1291 RALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWN 1350
+AL+KVP D YITTYPGQG GYT+EEAKT LKKCKSAFY+LPS N K+EILGTVSWN
Sbjct 1315 KALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWN 1374
Query 1351 LREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASI 1410
LREMLAHAEETRKLMP+C++ +AI++TIQRKYKGIKIQEG+VDYG RF+FYTSK VAS+
Sbjct 1375 LREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASL 1434
Query 1411 ITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSS 1470
I LN LNE LVTMP+GYVTHG NLEEAAR MRSLK PA VSVSSPDAVT YNGYLTSSS
Sbjct 1435 INTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS 1494
Query 1471 KTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSL 1530
KT EEHF+ET+SLAGSY+DWSYSGQ T+LG+EFLKRGDK VY+T +P FHLDGEV++
Sbjct 1495 KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYT-SNPTTFHLDGEVITF 1553
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNH 1590
D LK+LLSLREV+TIKVFTTVDN NLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH +H
Sbjct 1554 DNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSH 1613
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
EGKTF+VLP+DDTLR EAFEYYHT D SFLGRYMSALNHTKKWK+PQV GLTSIKWADNN
Sbjct 1614 EGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNN 1673
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
CYL++ LL LQQ+E+KFN PALQ+AYYRARAG+AANFCALILAY NKTVGELGDVRETM+
Sbjct 1674 CYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMS 1733
Query 1711 HLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDA 1770
+L QHANL+S KRVLNVVCK CGQ+ TTL GVEAVMYMGTLSY+ K GV IPC CG+ A
Sbjct 1734 YLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQA 1793
Query 1771 TQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHL 1830
T+YLVQQES FVMMSAPPA+Y+L+ GTF CA+EYTGNYQCGHY HIT+KETLY IDGA L
Sbjct 1794 TKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL 1853
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPID 1890
TK SEYKGP+TDVFYKE SYTTTIKPV+YKLDGV TEI+PKLD YYKKDN+Y+TEQPID
Sbjct 1854 TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPID 1913
Query 1891 LVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYR 1950
LVP QP PNASFDNFK C N KFADDLNQ+TG+ KPASREL VTFFPDLNGDVVAIDY+
Sbjct 1914 LVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYK 1973
Query 1951 HYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDT 2010
HY+ SFKKGAKLLHKPIVWH+N AT K T+KPNTWC+RCLWSTKPV+TSNSF+VL ED
Sbjct 1974 HYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDA 2033
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
QGMDNLACE +P SEEVVENPTIQK+V+EC+VKTTEVVG++ILKP++ +K+T+E+GH
Sbjct 2034 QGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHT 2093
Query 2071 DLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITT 2130
DLMAAYV+N+S+TIKKPNELS LGLKT+ATHG+AA+NSVPW I Y KPFL + TT
Sbjct 2094 DLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTT 2153
Query 2131 SNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDA 2190
+N R RV NYMPY FTLL QLCTFT+STNSRI+AS+PTTIAKN+VKSV K CL+A
Sbjct 2154 TNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEA 2213
Query 2191 GINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNS 2250
NY+KSP FSKL I +W LLLS+CLGSLI TAA GVL+SN G PSYC G RE YLNS
Sbjct 2214 SFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNS 2273
Query 2251 SNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML 2310
+NVT +C GS PCS+CLSGLDSLD+YP+LETIQ+TISS+K DLT GL AEW LAY+L
Sbjct 2274 TNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYIL 2333
Query 2311 FTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FT+FFY+LGL+AIMQ+FF YFA HFISNSWLMW II++VQMAP+SAMVRMYIFFASFYY+
Sbjct 2334 FTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYV 2393
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
WKSYVH++DGC SSTCMMCYKRNRATRVECTTIVNG++RSFYVYANGG+GFCK HNWNC+
Sbjct 2394 WKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCV 2453
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NCDTFC GSTFISDEVARDLSLQFKRPINPTDQSSYIVDSV VKNG++HLYFDKAGQKTY
Sbjct 2454 NCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTY 2513
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
ERH LSHFVNLDNLRANNTKGSLPINVIVFDGKSKC+ES++KSASVYYSQLMCQPILLLD
Sbjct 2514 ERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLD 2573
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
QALVSDVGDS EV+VKMFDAYV+TFS+TF+VPMEKLK LVATA +ELAK V+LD VLSTF
Sbjct 2574 QALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTF 2633
Query 2611 VSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACID 2670
+SAARQG VD+DV+TKDV+ECLKLSH SD+EVTGDSCNN+MLTYNKVENMTPRDLGACID
Sbjct 2634 ISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACID 2693
Query 2671 CNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNV 2730
C+ARHINAQVAKSHN++LIWNVKD+MSLSEQLRKQIRSAAKKNN+PF+LTCATTRQVVNV
Sbjct 2694 CSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNV 2753
Query 2731 ITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQ 2790
+TTKI+LKGGKIV+ K ++K TL+ + A + Y++ PVH +S H +++EIIGYKAI
Sbjct 2754 VTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAID 2813
Query 2791 DGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTV 2850
GVTRDI STD CFANKHA FD WFSQRGGSY NDK+CP++AA+ITRE+GF+VPGLPGT+
Sbjct 2814 GGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTI 2873
Query 2851 LRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYC 2910
LR NGDFLHFLPRVFSAVGNICYTPSKLIEY+DFATSACVLAAECTIFKDA GKPVPYC
Sbjct 2874 LRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYC 2933
Query 2911 YDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE 2970
YDTN+LEGS++Y LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFD+EYCRHGTCERSE
Sbjct 2934 YDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSE 2993
Query 2971 VGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGII 3030
G+C+STSGRWVLNN++YR+L GVFCGVDA+NL+ N+FTPL+QP+GALD+SAS+VAGGI+
Sbjct 2994 AGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIV 3053
Query 3031 AILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT 3090
AI+VTC AYYFM+FRR FGEY+HVVA N LLFLMSFT+LCL P YSFLPGVYSV YLYLT
Sbjct 3054 AIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLT 3113
Query 3091 FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFS 3150
FY TNDVSFLAH+QW MF+P+VPFWIT Y+ CIS KH +WFF+NYL++RV+FNGV+FS
Sbjct 3114 FYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFS 3173
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
TFEEAALCTFLLNKEMYLKLRS+ LLPLTQYNRYLALYNKYKYFSGA+DTTSYREAACCH
Sbjct 3174 TFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCH 3233
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKALNDFSNSG+DVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
Sbjct 3234 LAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3293
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVICT+EDMLNPNYEDLLIRKSNH+FLVQAGNVQLRVIGHSMQNC+L+LK
Sbjct 3294 WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLK 3353
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
VDT+NPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN TIKGSFLNGSCGSVGF
Sbjct 3354 VDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF 3413
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NIDYDCVSFCYMHHMELPTGVHAGTDLEG FYGPFVDRQTAQAAGTDTTIT+NVLAWLYA
Sbjct 3414 NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYA 3473
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA+LKE
Sbjct 3474 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKE 3533
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
LLQNGMNGRTILGS +LEDEFTPFDVVRQCSGVTFQ K+ +KGTHHW+LLT LTSLL+
Sbjct 3534 LLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLV 3593
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
LVQSTQWSLFFF+YENAFLPF +GI+A++A AM+ VKHKHAFLCLFLLPSLATVAYFNMV
Sbjct 3594 LVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMV 3653
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMN 3690
YMPASWVMRIMTWL++ DTSLSG++LKDCVMYASA+VLLILMTARTVYDD ARRVWTLMN
Sbjct 3654 YMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMN 3713
Query 3691 VITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
V+TLVYKVYYGNALDQAISMWAL+ISVTSNYSGVVTT+MFLAR IVF+CVEY P+ FITG
Sbjct 3714 VLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITG 3773
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKS 3810
NTLQCIMLVYCFLGY C CYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPK+
Sbjct 3774 NTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKN 3833
Query 3811 SIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3870
SIDAFKLNIKLLG+GGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ
Sbjct 3834 SIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3893
Query 3871 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPS 3930
LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPS
Sbjct 3894 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPS 3953
Query 3931 YAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 3990
YAA+ATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY
Sbjct 3954 YAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 4013
Query 3991 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4050
KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV
Sbjct 4014 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4073
Query 4051 VPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRA 4110
+PDY TYKNTCDG TFTYASALWEIQQVVDADSKIVQLSEI+MDNSPNLAWPLIVTALRA
Sbjct 4074 IPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA 4133
Query 4111 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKW 4170
NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN +KGGRFVLALLSD QDLKW
Sbjct 4134 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKW 4193
Query 4171 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4230
ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ
Sbjct 4194 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4253
Query 4231 AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
AGNATEVPANSTVLSFCAFAVD AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE
Sbjct 4254 AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4313
Query 4291 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVC 4350
ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTL+NTVCTVC
Sbjct 4314 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVC 4373
Query 4351 GMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
GMWKGYGCSCDQLREP++QSADA +FLNGFAV
Sbjct 4374 GMWKGYGCSCDQLREPMLQSADAQSFLNGFAV 4405
>sp|P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab OS=Severe acute
respiratory syndrome coronavirus 2 OX=2697049 GN=rep PE=1
SV=1
Length=7096
Score = 5995 bits (15553), Expect = 0.0, Method: Composition-based stats.
Identities = 3545/4408 (80%), Positives = 3944/4408 (89%), Gaps = 37/4408 (1%)
Query 1 MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV 60
MESLV G NEKTHVQLSLPVLQVRDVLVRGFGDSVEE LSEAR+HLK+GTCGLVE+EKGV
Sbjct 1 MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQHLKDGTCGLVEVEKGV 60
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN 120
LPQLEQPYVFIKRSDA + HGH +VELVAE++GIQYGRSG TLGVLVPHVGE P+AYR
Sbjct 61 LPQLEQPYVFIKRSDARTAPHGHVMVELVAELEGIQYGRSGETLGVLVPHVGEIPVAYRK 120
Query 121 VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG 180
VLLRKNGNKGAGGHSYG DLKS+DLGDELGTDP ED+++NWNTKH SG REL RELNGG
Sbjct 121 VLLRKNGNKGAGGHSYGADLKSFDLGDELGTDPYEDFQENWNTKHSSGVTRELMRELNGG 180
Query 181 AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW 240
A TRYVDNNFCGPDGYPL+CIKD LARAGK+ CTLSEQLD+I++KRGVYCCR+HEHEIAW
Sbjct 181 AYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTKRGVYCCREHEHEIAW 240
Query 241 FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI 300
+TERS+KSYE QTPFEIK AKKFDTF GECP FVFPLNS +K IQPRVEKKK +GFMGRI
Sbjct 241 YTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTIQPRVEKKKLDGFMGRI 300
Query 301 RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL 360
RSVYPVASP ECN M LSTLMKC+HC E SWQT DF+KATCE CGTENL EG TTCGYL
Sbjct 301 RSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEFCGTENLTKEGATTCGYL 360
Query 361 PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR 420
P NAVVK+ CPAC + E+GPEHS+A+YHN S ++T LRKGGRT FGGCVF+YVGC+NK
Sbjct 361 PQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGRTIAFGGCVFSYVGCHNKC 420
Query 421 AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF 480
AYWVPRASA+IG HTG+ G+ E LN++LLEIL +E+VNINIVGDF LNEE+AIILASF
Sbjct 421 AYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNINIVGDFKLNEEIAIILASF 480
Query 481 SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA 540
SASTSAF++T+K LDYK+FK IVESCGN+KVTKGK KGAWNIG+Q+S+L+PL F S+A
Sbjct 481 SASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGAWNIGEQKSILSPLYAFASEA 540
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
A V+RSIF+RTL+ A +S+ LQ+AA+TILDGIS+ SLRL+DAM++TSDL TN++++MAY
Sbjct 541 ARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLRLIDAMMFTSDLATNNLVVMAY 600
Query 601 VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV 660
+TGG+VQ TSQWL+N+ GT EKL+P+ +W+E K GVEFL+D WEI+KF+ T +IV
Sbjct 601 ITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEGVEFLRDGWEIVKFISTCACEIV 660
Query 661 KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC 720
GQI + IK+ V+ F +VNK L +C D + I GAKL++LNLGE F+ SKGLYR+C
Sbjct 661 GGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGGAKLKALNLGETFVTHSKGLYRKC 720
Query 721 IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
++ +E+ LLMPLKAPKE+ FLEG++ T + +EEVVLK G+L+ LE P +VG
Sbjct 721 VKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEVVLKTGDLQPLEQPTSEAVEAPLVG 780
Query 781 TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV 840
TPVC+NGLMLLEIKD E+YCAL+P ++ TNN F LKGGAP K VTFG+DTV EVQGYK+V
Sbjct 781 TPVCINGLMLLEIKDTEKYCALAPNMMVTNNTFTLKGGAPTK-VTFGDDTVIEVQGYKSV 839
Query 841 RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE 900
ITFELDER+DKVLNEKCS YTVE GTEV EFACVVA+AV+KTLQPVS+LLT +GIDLDE
Sbjct 840 NITFELDERIDKVLNEKCSAYTVELGTEVNEFACVVADAVIKTLQPVSELLTPLGIDLDE 899
Query 901 WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL 960
WS+AT+YLFD++GE +S MYCSFYPPDE+EE+ EEE T ++EYGTEDDYQG
Sbjct 900 WSMATYYLFDESGEFKLASHMYCSFYPPDEDEEEGDCEEEEFEPST-QYEYGTEDDYQGK 958
Query 961 PLEFGASAETVRVEEEEEEDWLDDTTEQ-------------------SEIEP--EPEPTP 999
PLEFGA++ ++ EEE+EEDWLDD ++Q E++P E E TP
Sbjct 959 PLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQDGSEDNQTTTIQTIVEVQPQLEMELTP 1018
Query 1000 ---EEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKA 1056
VN F+GYLKLTDNV IK DIV+EA+ P V+VNAAN++LKHGGGVAGALNKA
Sbjct 1019 VVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKA 1078
Query 1057 TNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
TN AMQ ESDDYI NGPL VGGSC+LSGHNLAK CLHVVGPN+N GEDIQLLK+AYENF
Sbjct 1079 TNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENF 1138
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPR- 1175
N ++LLAPLLSAGIFGA P+ SL+VCV TVRT VY+AV DK LY+++V +L+ +
Sbjct 1139 NQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLEMKSEKQ 1198
Query 1176 -----VEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL 1230
E PK+E P +SK SV Q+ D K KIKAC++EVTTTLEETKFLT LL
Sbjct 1199 VEQKIAEIPKEEVKPFITESK---PSVEQRKQDDK-KIKACVEEVTTTLEETKFLTENLL 1254
Query 1231 LFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLS 1290
L+ DING L+ DS ++ D++FL+KDAPY+VGDV+ G +T VVIP+KKAGGTTEML+
Sbjct 1255 LYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLA 1314
Query 1291 RALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWN 1350
+AL+KVP D YITTYPGQG GYT+EEAKT LKKCKSAFY+LPS N K+EILGTVSWN
Sbjct 1315 KALRKVPTDNYITTYPGQGLNGYTVEEAKTVLKKCKSAFYILPSIISNEKQEILGTVSWN 1374
Query 1351 LREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASI 1410
LREMLAHAEETRKLMP+C++ +AI++TIQRKYKGIKIQEG+VDYG RF+FYTSK VAS+
Sbjct 1375 LREMLAHAEETRKLMPVCVETKAIVSTIQRKYKGIKIQEGVVDYGARFYFYTSKTTVASL 1434
Query 1411 ITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSS 1470
I LN LNE LVTMP+GYVTHG NLEEAAR MRSLK PA VSVSSPDAVT YNGYLTSSS
Sbjct 1435 INTLNDLNETLVTMPLGYVTHGLNLEEAARYMRSLKVPATVSVSSPDAVTAYNGYLTSSS 1494
Query 1471 KTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSL 1530
KT EEHF+ET+SLAGSY+DWSYSGQ T+LG+EFLKRGDK VY+T +P FHLDGEV++
Sbjct 1495 KTPEEHFIETISLAGSYKDWSYSGQSTQLGIEFLKRGDKSVYYT-SNPTTFHLDGEVITF 1553
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNH 1590
D LK+LLSLREV+TIKVFTTVDN NLHTQ+VDMSMTYGQQFGPTYLDGADVTKIKPH +H
Sbjct 1554 DNLKTLLSLREVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSH 1613
Query 1591 EGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
EGKTF+VLP+DDTLR EAFEYYHT D SFLGRYMSALNHTKKWK+PQV GLTSIKWADNN
Sbjct 1614 EGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNN 1673
Query 1651 CYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMT 1710
CYL++ LL LQQ+E+KFN PALQ+AYYRARAG+AANFCALILAY NKTVGELGDVRETM+
Sbjct 1674 CYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMS 1733
Query 1711 HLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDA 1770
+L QHANL+S KRVLNVVCK CGQ+ TTL GVEAVMYMGTLSY+ K GV IPC CG+ A
Sbjct 1734 YLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQA 1793
Query 1771 TQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHL 1830
T+YLVQQES FVMMSAPPA+Y+L+ GTF CA+EYTGNYQCGHY HIT+KETLY IDGA L
Sbjct 1794 TKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALL 1853
Query 1831 TKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPID 1890
TK SEYKGP+TDVFYKE SYTTTIKPV+YKLDGV TEI+PKLD YYKKDN+Y+TEQPID
Sbjct 1854 TKSSEYKGPITDVFYKENSYTTTIKPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPID 1913
Query 1891 LVPTQPLPNASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYR 1950
LVP QP PNASFDNFK C N KFADDLNQ+TG+ KPASREL VTFFPDLNGDVVAIDY+
Sbjct 1914 LVPNQPYPNASFDNFKFVCDNIKFADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYK 1973
Query 1951 HYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDT 2010
HY+ SFKKGAKLLHKPIVWH+N AT K T+KPNTWC+RCLWSTKPV+TSNSF+VL ED
Sbjct 1974 HYTPSFKKGAKLLHKPIVWHVNNATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDA 2033
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
QGMDNLACE +P SEEVVENPTIQK+V+EC+VKTTEVVG++ILKP++ +K+T+E+GH
Sbjct 2034 QGMDNLACEDLKPVSEEVVENPTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHT 2093
Query 2071 DLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITT 2130
DLMAAYV+N+S+TIKKPNELS LGLKT+ATHG+AA+NSVPW I Y KPFL + TT
Sbjct 2094 DLMAAYVDNSSLTIKKPNELSRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTT 2153
Query 2131 SNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDA 2190
+N R RV NYMPY FTLL QLCTFT+STNSRI+AS+PTTIAKN+VKSV K CL+A
Sbjct 2154 TNIVTRCLNRVCTNYMPYFFTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEA 2213
Query 2191 GINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNS 2250
NY+KSP FSKL I +W LLLS+CLGSLI TAA GVL+SN G PSYC G RE YLNS
Sbjct 2214 SFNYLKSPNFSKLINIIIWFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNS 2273
Query 2251 SNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML 2310
+NVT +C GS PCS+CLSGLDSLD+YP+LETIQ+TISS+K DLT GL AEW LAY+L
Sbjct 2274 TNVTIATYCTGSIPCSVCLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYIL 2333
Query 2311 FTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FT+FFY+LGL+AIMQ+FF YFA HFISNSWLMW II++VQMAP+SAMVRMYIFFASFYY+
Sbjct 2334 FTRFFYVLGLAAIMQLFFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYV 2393
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
WKSYVH++DGC SSTCMMCYKRNRATRVECTTIVNG++RSFYVYANGG+GFCK HNWNC+
Sbjct 2394 WKSYVHVVDGCNSSTCMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCV 2453
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NCDTFC GSTFISDEVARDLSLQFKRPINPTDQSSYIVDSV VKNG++HLYFDKAGQKTY
Sbjct 2454 NCDTFCAGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTY 2513
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
ERH LSHFVNLDNLRANNTKGSLPINVIVFDGKSKC+ES++KSASVYYSQLMCQPILLLD
Sbjct 2514 ERHSLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLD 2573
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
QALVSDVGDS EV+VKMFDAYV+TFS+TF+VPMEKLK LVATA +ELAK V+LD VLSTF
Sbjct 2574 QALVSDVGDSAEVAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTF 2633
Query 2611 VSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACID 2670
+SAARQG VD+DV+TKDV+ECLKLSH SD+EVTGDSCNN+MLTYNKVENMTPRDLGACID
Sbjct 2634 ISAARQGFVDSDVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACID 2693
Query 2671 CNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNV 2730
C+ARHINAQVAKSHN++LIWNVKD+MSLSEQLRKQIRSAAKKNN+PF+LTCATTRQVVNV
Sbjct 2694 CSARHINAQVAKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNV 2753
Query 2731 ITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQ 2790
+TTKI+LKGGKIV+ K ++K TL+ + A + Y++ PVH +S H +++EIIGYKAI
Sbjct 2754 VTTKIALKGGKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAID 2813
Query 2791 DGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTV 2850
GVTRDI STD CFANKHA FD WFSQRGGSY NDK+CP++AA+ITRE+GF+VPGLPGT+
Sbjct 2814 GGVTRDIASTDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTI 2873
Query 2851 LRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYC 2910
LR NGDFLHFLPRVFSAVGNICYTPSKLIEY+DFATSACVLAAECTIFKDA GKPVPYC
Sbjct 2874 LRTTNGDFLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYC 2933
Query 2911 YDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSE 2970
YDTN+LEGS++Y LRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFD+EYCRHGTCERSE
Sbjct 2934 YDTNVLEGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSE 2993
Query 2971 VGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGII 3030
G+C+STSGRWVLNN++YR+L GVFCGVDA+NL+ N+FTPL+QP+GALD+SAS+VAGGI+
Sbjct 2994 AGVCVSTSGRWVLNNDYYRSLPGVFCGVDAVNLLTNMFTPLIQPIGALDISASIVAGGIV 3053
Query 3031 AILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT 3090
AI+VTC AYYFM+FRR FGEY+HVVA N LLFLMSFT+LCL P YSFLPGVYSV YLYLT
Sbjct 3054 AIVVTCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFTVLCLTPVYSFLPGVYSVIYLYLT 3113
Query 3091 FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFS 3150
FY TNDVSFLAH+QW MF+P+VPFWIT Y+ CIS KH +WFF+NYL++RV+FNGV+FS
Sbjct 3114 FYLTNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFS 3173
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
TFEEAALCTFLLNKEMYLKLRS+ LLPLTQYNRYLALYNKYKYFSGA+DTTSYREAACCH
Sbjct 3174 TFEEAALCTFLLNKEMYLKLRSDVLLPLTQYNRYLALYNKYKYFSGAMDTTSYREAACCH 3233
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKALNDFSNSG+DVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
Sbjct 3234 LAKALNDFSNSGSDVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3293
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVICT+EDMLNPNYEDLLIRKSNH+FLVQAGNVQLRVIGHSMQNC+L+LK
Sbjct 3294 WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLK 3353
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
VDT+NPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN TIKGSFLNGSCGSVGF
Sbjct 3354 VDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF 3413
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NIDYDCVSFCYMHHMELPTGVHAGTDLEG FYGPFVDRQTAQAAGTDTTIT+NVLAWLYA
Sbjct 3414 NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYA 3473
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA+LKE
Sbjct 3474 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKE 3533
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
LLQNGMNGRTILGS +LEDEFTPFDVVRQCSGVTFQ K+ +KGTHHW+LLT LTSLL+
Sbjct 3534 LLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTILTSLLV 3593
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
LVQSTQWSLFFF+YENAFLPF +GI+A++A AM+ VKHKHAFLCLFLLPSLATVAYFNMV
Sbjct 3594 LVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMMFVKHKHAFLCLFLLPSLATVAYFNMV 3653
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMN 3690
YMPASWVMRIMTWL++ DTSLSG++LKDCVMYASA+VLLILMTARTVYDD ARRVWTLMN
Sbjct 3654 YMPASWVMRIMTWLDMVDTSLSGFKLKDCVMYASAVVLLILMTARTVYDDGARRVWTLMN 3713
Query 3691 VITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
V+TLVYKVYYGNALDQAISMWAL+ISVTSNYSGVVTT+MFLAR IVF+CVEY P+ FITG
Sbjct 3714 VLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPIFFITG 3773
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKS 3810
NTLQCIMLVYCFLGY C CYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPK+
Sbjct 3774 NTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKN 3833
Query 3811 SIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3870
SIDAFKLNIKLLG+GGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ
Sbjct 3834 SIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQ 3893
Query 3871 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPS 3930
LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDIN+LCEEMLDNRATLQAIASEFSSLPS
Sbjct 3894 LHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIASEFSSLPS 3953
Query 3931 YAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 3990
YAA+ATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY
Sbjct 3954 YAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMY 4013
Query 3991 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4050
KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV
Sbjct 4014 KQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVV 4073
Query 4051 VPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRA 4110
+PDY TYKNTCDG TFTYASALWEIQQVVDADSKIVQLSEI+MDNSPNLAWPLIVTALRA
Sbjct 4074 IPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNLAWPLIVTALRA 4133
Query 4111 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKW 4170
NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYN +KGGRFVLALLSD QDLKW
Sbjct 4134 NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFVLALLSDLQDLKW 4193
Query 4171 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4230
ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ
Sbjct 4194 ARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQ 4253
Query 4231 AGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4290
AGNATEVPANSTVLSFCAFAVD AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE
Sbjct 4254 AGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPE 4313
Query 4291 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVC 4350
ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTL+NTVCTVC
Sbjct 4314 ANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCTVC 4373
Query 4351 GMWKGYGCSCDQLREPLMQSADASTFLN 4378
GMWKGYGCSCDQLREP++QSADA +FLN
Sbjct 4374 GMWKGYGCSCDQLREPMLQSADAQSFLN 4401
>sp|P0C6T5|R1A_BCHK5 Replicase polyprotein 1a OS=Bat coronavirus
HKU5 OX=694008 GN=1a PE=3 SV=1
Length=4481
Score = 4772 bits (12377), Expect = 0.0, Method: Composition-based stats.
Identities = 1532/4567 (34%), Positives = 2358/4567 (52%), Gaps = 302/4567 (7%)
Query 9 NEKT--HVQLSLPVLQVRDVLV---RGFGDSVEEALSEAREHLKNGTCGLV--ELEKGVL 61
EK HV L + D+++ F D E A E L G+ L + KG +
Sbjct 22 TEKRTDHVSLKASLCDAGDLVLKISPWFMDG-ESAYKHVSEQLSKGSKLLFVPQTLKGFI 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITL-----GVLVPHVGETPI 116
L P V++ T +V +A + G G TL G+ P +
Sbjct 81 RHLPGPRVYLVERLTGGTYSDPFMVNQLAYQNAAGEGVIGTTLQGKRVGMFFPFDADLVT 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKSY------DLGDELGTDPIEDYEQNWNTKHGSGAL 170
LLRK KG GG+ + Y DL D L DP Y Q+
Sbjct 141 GEFQFLLRK---KGFGGNRFRDAPWDYNWTPYSDLMDALEADPCGKYSQS---------- 187
Query 171 RELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGV 228
L ++L GG T +D CG +G P+ +A G K +E +S R +
Sbjct 188 --LLKKLVGGDFTP-IDQYMCGKNGKPIAEFAALMASEGITKLADVEAEVKSRTDSDRYI 244
Query 229 YCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRV 288
++ + I W +R D +Y Q+ F + S + DT + + P+ F + S+++VI P
Sbjct 245 -VFKNKLYRIVWNVQRKDVAYSKQSAFTMNSIVQLDTME-DVPRHSFTIGSEIQVIAPST 302
Query 289 EKKKTEGFMGRIRSVYPVASPQ---ECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCG 345
+ + R +Y Q E N ++ S + C C + SW T + ++ CG
Sbjct 303 AVQANGHLNLKQRLLYAFYGKQAVSEPNYIYHSAYVDCTSCGKGSWLTGNAVQGFACDCG 362
Query 346 TENLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRT- 403
+ + G + NAV+ CP +D E +H++ + + + G+T
Sbjct 363 AHYCANDVDLQSSGLVRKNAVLLTTCPCNKDGEC--KHTLPQLVSMMTDKCDVEVVGKTF 420
Query 404 -RCFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILS 455
+GG ++AY+GC +++PRA + I +G TG ET N L
Sbjct 421 ILTYGGVIYAYMGCSGGTMHFIPRAKSCVSKIGDAIFTGCTGTWSKVCETAN----LFLE 476
Query 456 RERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGK 515
R + IN V +F L E V +L+ ++S D ++ ++ + + G + VT G
Sbjct 477 RAQHAINFVNEFVLTETVVALLSGTTSSIEELRDLCRNATFEKVRDYLTPRG-WIVTMGS 535
Query 516 PVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISE 575
++G N+G +C A ++ S + + L + LD ++
Sbjct 536 YIEGVINVGA-----AGVCNAALNAPFIVLSGLGESFKKVAATPWKLCSSLRETLDHYAD 590
Query 576 QSLRLV-------DAMVYTSDLLTNSVII--MAYVTGGLVQQTSQWLSNLLGTTVEKLRP 626
V D YT+ LL +V+ AY V + + L+NL+ ++ +
Sbjct 591 SITYRVFPYDIPCDVTDYTALLLDCAVLTGASAYFVARYVDEKVEQLTNLVFSSCQSAVA 650
Query 627 IF-EWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKA 685
F + + A +F+ D + ++K + ++ V D +K F+ +++KA
Sbjct 651 AFVQACMSTYKATAKFISDMFTLIKVVSERLYVYTSVGFVVVGDYSSQLLKQFMHILSKA 710
Query 686 LEMCIDQVTIAGAKLRSL--NLGEVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEV 739
+++ V+ AG+KL S+ N + + S Y +G+ +Q L++P + K++
Sbjct 711 MQLLHTTVSWAGSKLPSVVYNGRDSLVFPSGTYYCVSTQGRSLQDQFDLVIPGDLSKKQI 770
Query 740 TFLEGDSHDTVLTSE----EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLE-IK 794
LE + T + + V + G+LE P + +VG V ++ + + ++
Sbjct 771 GILEPTPNSTTVDKKINTNVVEVVVGQLE----PTKEHSPELVVGDYVIISNKIFVRSVE 826
Query 795 DKE--QYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDK 852
D E Y + G + +FRLKGGAP KGV FG + E+ ++V + +++ +D
Sbjct 827 DSETVFYPLCTDGKIV-PTLFRLKGGAPPKGVKFGGEQTKEITAVRSVSVDYDVHPVLDA 885
Query 853 VL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDD 911
+L + + +TVE V +F VV + V++ L + G DL++++ Y+++
Sbjct 886 LLAGSELATFTVEKDLPVKDFVDVVKDEVIELLSKLLRGYNVDGFDLEDFADTPCYVYNA 945
Query 912 AGEENFSSRMYCSFYPPDEEEEDDAECEEEEI-DETCEHEYGTEDDYQGLPLEFGASAET 970
G+ +SS M S P EE + EC+++ + DE E E+D + A+ E
Sbjct 946 EGDLAWSSTMTFSVNPV---EEVEEECDDDYVEDEYLSEEMLVEEDEN----SWAAAVEA 998
Query 971 VRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA 1030
V E+ + D L + SE P + V + T+ V + +++ +Q A
Sbjct 999 VIPMEDVQLDTLVAEIDVSE--------PADDVAEQAS----TEEVEVPSACVLEASQVA 1046
Query 1031 NPMVIVN-----AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
N + + +++I L A A + A ++ KL+ VG
Sbjct 1047 NAAEVESCEAEVSSSIPLHEDANAAKANDCAEGMPALDSTETVSKLSVDTPVGD------ 1100
Query 1086 HNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQ 1145
V + + + + + +S+ ++ P + P ++L V+
Sbjct 1101 ---------VTQDDATSSNATVISEDVHTATHSKGLVAVPEVV-------PEKALGTSVE 1144
Query 1146 TVRTQVYIAVNDKALYEQ--VVMDYLDNLKP-RVEAPKQEEPPNTEDSKTEEKSVVQKPV 1202
+R+ V + +L ++ V++ + KP RV+ PK E P V
Sbjct 1145 RMRSTSEWTVVETSLKQETAVIVKNDSSAKPQRVKKPKAENPLKNFKHIVLNNDVTLVFG 1204
Query 1203 DVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYM 1262
D +A D + T I + S +++ E ++ P
Sbjct 1205 DAIAVARATEDCILVNAANTHLKHG-----GGIAAAIDRASGGLVQAESDDYVNFYGPLN 1259
Query 1263 VGDVITSGD------ITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLE 1316
VGD I VV P +A ++L R K ++Y AG
Sbjct 1260 VGDSTLLKGHGLATGILHVVGPDARANQDIQLLKRCYKAF--NKYPLVVSPLISAGIFCV 1317
Query 1317 EAKTALKKCKSA-----FYVLPSE-------APNAKEEI-LGTVSWNLREMLAHAEETRK 1363
E + +L+ S + V+ SE AP + W R ++ +A+
Sbjct 1318 EPRVSLEYLLSVVHTKTYVVVNSEKVYNDLAAPKPPTGLTYSHEGW--RGIIRNAKSFGF 1375
Query 1364 LMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVT 1423
IC D A ++ + + + VD GV+++ Y+SK+P+ IIT N+ + +
Sbjct 1376 TCFICTDQSANAKLLKGRGVDLTKKTQTVD-GVKYYLYSSKDPLTDIITAANAC-KGICA 1433
Query 1424 MPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSL 1483
MPIGYVTHG +L +A + ++ + P V ++S D V N + + +T E+ F+ TV
Sbjct 1434 MPIGYVTHGLDLAQAGQQVKKITVPYVCLLASKDQVPILNSDV--AVQTPEQSFINTVIA 1491
Query 1484 AGSYRDWSY-SGQRTELGVEF---LKRGDKIV------YHTLESPVEFHLDGEVLSLDKL 1533
G Y W +G+ GV + L D+ + ++ ++ + D SL+K
Sbjct 1492 NGGYHCWHLVTGELIVKGVSYRKLLNWSDQTICYADNKFYVVKGQIALPFD----SLEKC 1547
Query 1534 KSLLSLR--EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHE 1591
++ L+ R + K + V T+D N T +++ + TY Q G + G+D++ P
Sbjct 1548 RTYLTSRAAQQKNVDVLVTIDGVNFRTVVLNNTTTYRVQLGSVFYKGSDISDTIPTEKMS 1607
Query 1592 GKTFFVLPSDDTLRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
G+ ++ + E Y T D +FL RY S L KKWK+ G+ S+K NN
Sbjct 1608 GEAVYLADNLSEAEKAVLSEVYGTADTAFLHRYYSLLALVKKWKYTVHDGVKSLKLNSNN 1667
Query 1651 CYLSSVLLALQQLE-VKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETM 1709
CY++ +L L L+ +KF PALQ AY + + GD+ F ALI+AY + T GE D +
Sbjct 1668 CYVNVTMLMLDMLKEIKFIVPALQAAYLKHKGGDSTEFIALIMAYGDCTYGEPDDASRLL 1727
Query 1710 THLLQHANLES-AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
+L A L + AK V C CG + TT TG++A +Y+G S D L C CG
Sbjct 1728 HTILSKAELTTQAKMVWRQWCNVCGVQDTTTTGLKACIYVGMNSLDELHATHEECCQCGD 1787
Query 1769 DATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTG-------NYQCGHYTHITAKET 1821
+ LV+ + ++++S + + +YT GHY H+ K+
Sbjct 1788 VRKRQLVEHNAPWLLLSGLNEAKVMTPTSQSAGPDYTAFNVFQGVETSVGHYLHVRVKDN 1847
Query 1822 L-YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKD 1880
L Y+ D L+K S+ K +TDV+Y + Y+ V Y LDG T+ +++P L +Y KD
Sbjct 1848 LLYKYDSGSLSKTSDMKCKMTDVYYPKQRYSADCNVVVYSLDGNTWADVDPDLSAFYMKD 1907
Query 1881 NAYYTEQP-IDLVPTQPLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASREL 1932
Y+T++P I+ P L + + N L + D N + GF +KP S++L
Sbjct 1908 GKYFTKKPVIEYSPATILSGSVYTNSCLVGHDGTIGSDAISSSFNNLLGFDNSKPVSKKL 1967
Query 1933 SVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWS 1992
+ +FFPD GDV+ +Y Y +K GA L KPI+W N K N LR ++
Sbjct 1968 TYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWVNNSKFDSALNKFNRATLRQVYD 2027
Query 1993 TKPVDTSNSFEVLAVEDTQGMDNLAC-ESQQPTSE-EVVENPTIQKEVIECD-VKTTEVV 2049
PV N + VL Q ++ A E +P S +V E+ + +I+C +K V
Sbjct 2028 IAPVTLENKYTVLQDNQIQQVEVEAPKEDAKPQSPVQVAEDIDNKLPIIKCKGLKKPFVK 2087
Query 2050 GNVILKPSDEGVKVTQELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG---IA 2105
+GV V LG +DL A YV+ N + + K N S + T+ IA
Sbjct 2088 DGYSFVNDPQGVNVIDTLGIDDLRALYVDRNLRLIVLKENNWSALFNIHTVEKGDLSVIA 2147
Query 2106 AINSVPWS-KILAYVKPFLGQAAITTSNCAK-------RLAQRVFNN--YMPYVFTLLFQ 2155
A S+ KIL Q A T N R+ + V N + F LL
Sbjct 2148 ASGSITRRVKILLGASSLFAQFASVTVNVTTAMGKALGRMTRNVITNTGIIGQGFALLKM 2207
Query 2156 L----CTFTKSTN-SRIRASLPTTIAKNSVKS-VAKLCLDAGINYVKSPKFSKLFTIAMW 2209
L TF KS N S ++ + V + V K C A + V KF ++ +
Sbjct 2208 LLILPFTFWKSKNQSTVKVEVGALRTAGIVTTNVVKQCASAAYD-VLVVKFKRIDWKSTL 2266
Query 2210 LLLLSIC------------------LGSLICVTAAFGVLL------SNFGAPSYCNGVRE 2245
LL IC L S + + A G+L S G S C+G+ E
Sbjct 2267 RLLFLICTTGLLLSSLYYLFLFHQVLTSDVMLDGAEGMLATYRELRSYLGIHSLCDGMVE 2326
Query 2246 LYLNSSNVTTMDFCEG-SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEW 2304
Y N S DFC S C+ CL G DSL Y A + IQ ++SY +++ + E+
Sbjct 2327 AYRNVS-YDVNDFCSNRSALCNWCLIGQDSLTRYSAFQMIQTHVTSYVINIDWVWFVMEF 2385
Query 2305 VLAYMLFTKFFYLLGLSAIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYI 2362
LAY+L+T F +L L Q FF Y + + S ++L+ V P+ +VR+Y
Sbjct 2386 ALAYVLYTSTFNVLLLVVSSQYFFSYTGAFVNWRSYNYLVSGYFFCVTHIPLLGLVRIYN 2445
Query 2363 FFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFC 2422
F A +++ + Y H+++GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG FC
Sbjct 2446 FLACLWFLRRFYNHVINGCKDTACLLCYKRNRLTRVEASTVVCGSKRTFYIVANGGTSFC 2505
Query 2423 KTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYF 2482
HNWNC++CDT G+TFI +EVA DL+ +R + PTD+S Y V+SV VK+ + L++
Sbjct 2506 CRHNWNCVDCDTAGIGNTFICEEVANDLTTSLRRLVKPTDKSHYYVESVTVKDSVVQLHY 2565
Query 2483 DKAGQKTYERHPLSHFVNLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYY 2538
+ G YER+PL +F NLD L+ G N +++D + E+ ++SA VYY
Sbjct 2566 SREGASCYERYPLCYFTNLDKLKFKEVCKTPTGIPEHNFLIYDSSDRGQENLARSACVYY 2625
Query 2539 SQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELA 2598
SQ++ +P+LL+D +V+ VGDS E++ KM D+YV++F + F V +KL LVATA +
Sbjct 2626 SQVLSKPMLLVDSNMVTTVGDSREIASKMLDSYVNSFISLFGVNRDKLDKLVATARDCVK 2685
Query 2599 KGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKV 2657
+G V+ TF AAR V++DV+T +++ L+ ++ DL++T + NN++ +Y K
Sbjct 2686 RGDDFQTVIKTFTDAARGPAGVESDVETSSIVDALQYAYKHDLQLTTEGFNNYVPSYIKP 2745
Query 2658 ENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPF 2717
+++ DLG ID NA +N ++ N + IWN DYM LS+ L++QIR A +K NIPF
Sbjct 2746 DSVATADLGCLIDLNAASVNQTSIRNANGACIWNSSDYMKLSDSLKRQIRIACRKCNIPF 2805
Query 2718 RLTCATTRQVVNVITTKIS---LKGG------KIVSTCFKLMLKATLLCVLAALVCYIVM 2768
RLT + R N+++ K S L GG K+ +K TL+ A++ Y+ +
Sbjct 2806 RLTTSRLRSADNILSVKFSATKLSGGAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYLCL 2865
Query 2769 PVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKS 2827
P +S + + I+ YK +++G+ RDI +D CFANK+ F WF++ GG + ND S
Sbjct 2866 PAFNMSQVSFHEDRILTYKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGLFNNDIS 2925
Query 2828 CPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFAT 2887
CPV A+I G VP LP V + + F+ RVF++ N+CYTP+ I Y F+
Sbjct 2926 CPVTVAVIAGVAGARVPNLPANV-AWVGRQIVLFVSRVFASSNNVCYTPTAEIPYERFSD 2984
Query 2888 SACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYL 2946
S CVLA+ECT+F+DA GK PYCYD +L G+ +Y +++P RY + D I+FP
Sbjct 2985 SGCVLASECTLFRDAEGKINPYCYDPTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEVVF 3044
Query 2947 EGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIAN 3006
E ++R+ T YCR G+CE + G+C++T+G W + N+HY GV+CG + +++
Sbjct 3045 ESTLRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIVRR 3104
Query 3007 IFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSF 3066
+ L QPV +S S+ G ++ I +T A YY K +R +Y L++
Sbjct 3105 LGLSLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALLNS 3164
Query 3067 TILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCIS 3126
LC V + L Y+ Y Y TFY T + +F+ H+ WF MF +VP W+ Y+ +
Sbjct 3165 LCLCFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVGVC 3224
Query 3127 LKHCHWFFNNYLRKRV--MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY 3184
L+H W + +K V +G +F++AA F++NK+ Y+ LR+ + YNRY
Sbjct 3225 LRHLLWVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS--ITQDSYNRY 3282
Query 3185 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFR 3244
L+++NKYKY+SGA+DT SYREA+ HL KAL +S +G+DVL+QPP S+TS+VLQSG
Sbjct 3283 LSMFNKYKYYSGAMDTASYREASAAHLCKALQVYSETGSDVLFQPPNCSVTSSVLQSGLV 3342
Query 3245 KMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNH 3304
KMA PSG VE CMVQVTCG+ TLNGLWLD+ V+CPRHV+C A+ + +PNY+ LL+ K+N
Sbjct 3343 KMAAPSGVVENCMVQVTCGSMTLNGLWLDNYVWCPRHVMCPADQLSDPNYDALLVSKTNL 3402
Query 3305 SFLVQAG---NVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
SF+VQ LRV+GH+M LL+L V+++NP+TP Y F ++PG +FSVLACYNG
Sbjct 3403 SFIVQKNVGAPANLRVVGHTMVGTLLKLTVESANPQTPAYTFTTVKPGASFSVLACYNGR 3462
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P+GV+ MR N TIKGSFL GSCGSVG+ + + ++FCYMH MEL G H G +G
Sbjct 3463 PTGVFMVNMRQNSTIKGSFLCGSCGSVGYTQEGNVINFCYMHQMELSNGTHTGCAFDGVM 3522
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YG F DRQ Q +D T+N++AWLYAA++NG WF+ T + FN AM +
Sbjct 3523 YGAFEDRQVHQVQLSDKYCTINIVAWLYAAILNGCNWFVKPNKTGIATFNEWAMSNQFTE 3582
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ L+ +TG++V + A++ L G G+TILG+++LEDEFTP DV Q
Sbjct 3583 FIG--TQSVDMLAHKTGVSVEQLLYAIQTL-HKGFQGKTILGNSMLEDEFTPDDVNMQVM 3639
Query 3542 GVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAAC 3601
GV Q K+I G HW+ T L + + +Q T+++++ +++E L T ++ + AC
Sbjct 3640 GVVMQSGVKRISYGLVHWLFTTLLLAYVATLQLTKFTIWNYLFEVIPLQLTPLVLCVMAC 3699
Query 3602 AMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPA----SWVMRIMTWLELADTSLSGYRLK 3657
ML VKHKH FL LFLLP+ + Y N+VY P S ++ + WL A +
Sbjct 3700 VMLTVKHKHTFLTLFLLPTAICLTYANIVYEPQTPVSSALIAVANWLNPASVYMRTTH-T 3758
Query 3658 DCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISV 3717
D +Y S L ++ R +A+ L + + Y G+ ++ + ++
Sbjct 3759 DLGVYLSLCFALAVVVRRLYRPNASNLALALGSAMVWFYTYTTGDC-SSPLTYLMFLTTL 3817
Query 3718 TSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
TS+Y+ V + +A+ V Y P ++ ++L+Y +GY C YFG+F LL
Sbjct 3818 TSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYLAVGYFCTVYFGVFSLL 3877
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N R+ LGVYDY VSTQEFRY+ GL P++S +A +LN+KL+GIGG PCIK+A+VQS
Sbjct 3878 NLKLRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIASVQS 3937
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++D+KCTSVVLLSVLQQL +E++SK WA CV+LHNDIL A D TEAF+ V L + L+S
Sbjct 3938 KLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFATLMS 3997
Query 3898 MQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKK 3956
VD+ L ++LD+ + LQA SEFS L SYA AQ +Y++A+ +GD S VLK
Sbjct 3998 FSANVDLEALASDLLDHPSVLQATLSEFSHLASYAELEAAQSSYQKALNSGDASPQVLKA 4057
Query 3957 LKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRK 4016
L+K++N+AK+ +++D A+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++K
Sbjct 4058 LQKAVNIAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKK 4117
Query 4017 LDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQ 4076
LDND LN +I+NAR+GCVPL+++PL + KL VV+PD + + +YA ALW+I
Sbjct 4118 LDNDVLNGVISNARNGCVPLSVVPLCASNKLRVVIPDITIWNKVVTWPSLSYAGALWDIS 4177
Query 4077 QVVDADSKIVQLSEINMDNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSCAAGT 4135
+ + D ++V+ S++ N +L WPL++ R A+SAV LQNNE+ P L+ M +AG
Sbjct 4178 LINNVDGEVVKSSDVTETN-ESLTWPLVLECTRAASSAVTLQNNEIRPSGLKTMVVSAGI 4236
Query 4136 TQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTD 4195
C + ++LAYY +G + ++ +LS++ LKWA+ DG I EL+PPC+F+
Sbjct 4237 DHANC-NTSSLAYYEPVEGRKMLMGILSENAHLKWAKVEGRDGFVNI--ELQPPCKFLIA 4293
Query 4196 TPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAK 4255
PKGP+V+YLYF+K LNNL+RG +LG +AATVRLQAG+ TE NS+VLS F+VDP K
Sbjct 4294 GPKGPEVRYLYFVKNLNNLHRGQLLGHIAATVRLQAGSNTEFAINSSVLSAVTFSVDPGK 4353
Query 4256 AYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPN 4315
AY D++ +GG P+TNCVKML TGTG A++V PEAN DQ+++GGAS CLYCR HI+HP+
Sbjct 4354 AYLDFVNAGGAPLTNCVKMLTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIEHPD 4413
Query 4316 PKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADAST 4375
G C KGK+VQ+P DPVGF L+NT C VC W G+GC+CD LR + + S
Sbjct 4414 VTGVCKFKGKFVQVPLH-IRDPVGFCLQNTPCNVCQFWIGHGCNCDALRGTTIPQSKDSN 4472
Query 4376 FLNGFAV 4382
FLN V
Sbjct 4473 FLNESGV 4479
>sp|P0C6W4|R1AB_BCHK5 Replicase polyprotein 1ab OS=Bat coronavirus
HKU5 OX=694008 GN=rep PE=3 SV=1
Length=7182
Score = 4769 bits (12370), Expect = 0.0, Method: Composition-based stats.
Identities = 1531/4563 (34%), Positives = 2357/4563 (52%), Gaps = 302/4563 (7%)
Query 9 NEKT--HVQLSLPVLQVRDVLV---RGFGDSVEEALSEAREHLKNGTCGLV--ELEKGVL 61
EK HV L + D+++ F D E A E L G+ L + KG +
Sbjct 22 TEKRTDHVSLKASLCDAGDLVLKISPWFMDG-ESAYKHVSEQLSKGSKLLFVPQTLKGFI 80
Query 62 PQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITL-----GVLVPHVGETPI 116
L P V++ T +V +A + G G TL G+ P +
Sbjct 81 RHLPGPRVYLVERLTGGTYSDPFMVNQLAYQNAAGEGVIGTTLQGKRVGMFFPFDADLVT 140
Query 117 AYRNVLLRKNGNKGAGGHSYGIDLKSY------DLGDELGTDPIEDYEQNWNTKHGSGAL 170
LLRK KG GG+ + Y DL D L DP Y Q+
Sbjct 141 GEFQFLLRK---KGFGGNRFRDAPWDYNWTPYSDLMDALEADPCGKYSQS---------- 187
Query 171 RELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGV 228
L ++L GG T +D CG +G P+ +A G K +E +S R +
Sbjct 188 --LLKKLVGGDFTP-IDQYMCGKNGKPIAEFAALMASEGITKLADVEAEVKSRTDSDRYI 244
Query 229 YCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRV 288
++ + I W +R D +Y Q+ F + S + DT + + P+ F + S+++VI P
Sbjct 245 -VFKNKLYRIVWNVQRKDVAYSKQSAFTMNSIVQLDTME-DVPRHSFTIGSEIQVIAPST 302
Query 289 EKKKTEGFMGRIRSVYPVASPQ---ECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCG 345
+ + R +Y Q E N ++ S + C C + SW T + ++ CG
Sbjct 303 AVQANGHLNLKQRLLYAFYGKQAVSEPNYIYHSAYVDCTSCGKGSWLTGNAVQGFACDCG 362
Query 346 TENLVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRT- 403
+ + G + NAV+ CP +D E +H++ + + + G+T
Sbjct 363 AHYCANDVDLQSSGLVRKNAVLLTTCPCNKDGEC--KHTLPQLVSMMTDKCDVEVVGKTF 420
Query 404 -RCFGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILS 455
+GG ++AY+GC +++PRA + I +G TG ET N L
Sbjct 421 ILTYGGVIYAYMGCSGGTMHFIPRAKSCVSKIGDAIFTGCTGTWSKVCETAN----LFLE 476
Query 456 RERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGK 515
R + IN V +F L E V +L+ ++S D ++ ++ + + G + VT G
Sbjct 477 RAQHAINFVNEFVLTETVVALLSGTTSSIEELRDLCRNATFEKVRDYLTPRG-WIVTMGS 535
Query 516 PVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISE 575
++G N+G +C A ++ S + + L + LD ++
Sbjct 536 YIEGVINVGA-----AGVCNAALNAPFIVLSGLGESFKKVAATPWKLCSSLRETLDHYAD 590
Query 576 QSLRLV-------DAMVYTSDLLTNSVII--MAYVTGGLVQQTSQWLSNLLGTTVEKLRP 626
V D YT+ LL +V+ AY V + + L+NL+ ++ +
Sbjct 591 SITYRVFPYDIPCDVTDYTALLLDCAVLTGASAYFVARYVDEKVEQLTNLVFSSCQSAVA 650
Query 627 IF-EWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKA 685
F + + A +F+ D + ++K + ++ V D +K F+ +++KA
Sbjct 651 AFVQACMSTYKATAKFISDMFTLIKVVSERLYVYTSVGFVVVGDYSSQLLKQFMHILSKA 710
Query 686 LEMCIDQVTIAGAKLRSL--NLGEVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEV 739
+++ V+ AG+KL S+ N + + S Y +G+ +Q L++P + K++
Sbjct 711 MQLLHTTVSWAGSKLPSVVYNGRDSLVFPSGTYYCVSTQGRSLQDQFDLVIPGDLSKKQI 770
Query 740 TFLEGDSHDTVLTSE----EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLE-IK 794
LE + T + + V + G+LE P + +VG V ++ + + ++
Sbjct 771 GILEPTPNSTTVDKKINTNVVEVVVGQLE----PTKEHSPELVVGDYVIISNKIFVRSVE 826
Query 795 DKE--QYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDK 852
D E Y + G + +FRLKGGAP KGV FG + E+ ++V + +++ +D
Sbjct 827 DSETVFYPLCTDGKIV-PTLFRLKGGAPPKGVKFGGEQTKEITAVRSVSVDYDVHPVLDA 885
Query 853 VL-NEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDD 911
+L + + +TVE V +F VV + V++ L + G DL++++ Y+++
Sbjct 886 LLAGSELATFTVEKDLPVKDFVDVVKDEVIELLSKLLRGYNVDGFDLEDFADTPCYVYNA 945
Query 912 AGEENFSSRMYCSFYPPDEEEEDDAECEEEEI-DETCEHEYGTEDDYQGLPLEFGASAET 970
G+ +SS M S P EE + EC+++ + DE E E+D + A+ E
Sbjct 946 EGDLAWSSTMTFSVNP---VEEVEEECDDDYVEDEYLSEEMLVEEDEN----SWAAAVEA 998
Query 971 VRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA 1030
V E+ + D L + SE P + V + T+ V + +++ +Q A
Sbjct 999 VIPMEDVQLDTLVAEIDVSE--------PADDVAEQAS----TEEVEVPSACVLEASQVA 1046
Query 1031 NPMVIVN-----AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
N + + +++I L A A + A ++ KL+ VG
Sbjct 1047 NAAEVESCEAEVSSSIPLHEDANAAKANDCAEGMPALDSTETVSKLSVDTPVGD------ 1100
Query 1086 HNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQ 1145
V + + + + + +S+ ++ P + P ++L V+
Sbjct 1101 ---------VTQDDATSSNATVISEDVHTATHSKGLVAVPEVV-------PEKALGTSVE 1144
Query 1146 TVRTQVYIAVNDKALYEQ--VVMDYLDNLKP-RVEAPKQEEPPNTEDSKTEEKSVVQKPV 1202
+R+ V + +L ++ V++ + KP RV+ PK E P V
Sbjct 1145 RMRSTSEWTVVETSLKQETAVIVKNDSSAKPQRVKKPKAENPLKNFKHIVLNNDVTLVFG 1204
Query 1203 DVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYM 1262
D +A D + T I + S +++ E ++ P
Sbjct 1205 DAIAVARATEDCILVNAANTHLKHG-----GGIAAAIDRASGGLVQAESDDYVNFYGPLN 1259
Query 1263 VGDVITSGD------ITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLE 1316
VGD I VV P +A ++L R K ++Y AG
Sbjct 1260 VGDSTLLKGHGLATGILHVVGPDARANQDIQLLKRCYKAF--NKYPLVVSPLISAGIFCV 1317
Query 1317 EAKTALKKCKSA-----FYVLPSE-------APNAKEEI-LGTVSWNLREMLAHAEETRK 1363
E + +L+ S + V+ SE AP + W R ++ +A+
Sbjct 1318 EPRVSLEYLLSVVHTKTYVVVNSEKVYNDLAAPKPPTGLTYSHEGW--RGIIRNAKSFGF 1375
Query 1364 LMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVT 1423
IC D A ++ + + + VD GV+++ Y+SK+P+ IIT N+ + +
Sbjct 1376 TCFICTDQSANAKLLKGRGVDLTKKTQTVD-GVKYYLYSSKDPLTDIITAANAC-KGICA 1433
Query 1424 MPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSL 1483
MPIGYVTHG +L +A + ++ + P V ++S D V N + + +T E+ F+ TV
Sbjct 1434 MPIGYVTHGLDLAQAGQQVKKITVPYVCLLASKDQVPILNSDV--AVQTPEQSFINTVIA 1491
Query 1484 AGSYRDWSY-SGQRTELGVEF---LKRGDKIV------YHTLESPVEFHLDGEVLSLDKL 1533
G Y W +G+ GV + L D+ + ++ ++ + D SL+K
Sbjct 1492 NGGYHCWHLVTGELIVKGVSYRKLLNWSDQTICYADNKFYVVKGQIALPFD----SLEKC 1547
Query 1534 KSLLSLR--EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHE 1591
++ L+ R + K + V T+D N T +++ + TY Q G + G+D++ P
Sbjct 1548 RTYLTSRAAQQKNVDVLVTIDGVNFRTVVLNNTTTYRVQLGSVFYKGSDISDTIPTEKMS 1607
Query 1592 GKTFFVLPSDDTLRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNN 1650
G+ ++ + E Y T D +FL RY S L KKWK+ G+ S+K NN
Sbjct 1608 GEAVYLADNLSEAEKAVLSEVYGTADTAFLHRYYSLLALVKKWKYTVHDGVKSLKLNSNN 1667
Query 1651 CYLSSVLLALQQLE-VKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETM 1709
CY++ +L L L+ +KF PALQ AY + + GD+ F ALI+AY + T GE D +
Sbjct 1668 CYVNVTMLMLDMLKEIKFIVPALQAAYLKHKGGDSTEFIALIMAYGDCTYGEPDDASRLL 1727
Query 1710 THLLQHANLES-AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
+L A L + AK V C CG + TT TG++A +Y+G S D L C CG
Sbjct 1728 HTILSKAELTTQAKMVWRQWCNVCGVQDTTTTGLKACIYVGMNSLDELHATHEECCQCGD 1787
Query 1769 DATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTG-------NYQCGHYTHITAKET 1821
+ LV+ + ++++S + + +YT GHY H+ K+
Sbjct 1788 VRKRQLVEHNAPWLLLSGLNEAKVMTPTSQSAGPDYTAFNVFQGVETSVGHYLHVRVKDN 1847
Query 1822 L-YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKD 1880
L Y+ D L+K S+ K +TDV+Y + Y+ V Y LDG T+ +++P L +Y KD
Sbjct 1848 LLYKYDSGSLSKTSDMKCKMTDVYYPKQRYSADCNVVVYSLDGNTWADVDPDLSAFYMKD 1907
Query 1881 NAYYTEQP-IDLVPTQPLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASREL 1932
Y+T++P I+ P L + + N L + D N + GF +KP S++L
Sbjct 1908 GKYFTKKPVIEYSPATILSGSVYTNSCLVGHDGTIGSDAISSSFNNLLGFDNSKPVSKKL 1967
Query 1933 SVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWS 1992
+ +FFPD GDV+ +Y Y +K GA L KPI+W N K N LR ++
Sbjct 1968 TYSFFPDFEGDVILTEYSTYDPIYKNGAMLHGKPILWVNNSKFDSALNKFNRATLRQVYD 2027
Query 1993 TKPVDTSNSFEVLAVEDTQGMDNLAC-ESQQPTSE-EVVENPTIQKEVIECD-VKTTEVV 2049
PV N + VL Q ++ A E +P S +V E+ + +I+C +K V
Sbjct 2028 IAPVTLENKYTVLQDNQIQQVEVEAPKEDAKPQSPVQVAEDIDNKLPIIKCKGLKKPFVK 2087
Query 2050 GNVILKPSDEGVKVTQELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG---IA 2105
+GV V LG +DL A YV+ N + + K N S + T+ IA
Sbjct 2088 DGYSFVNDPQGVNVIDTLGIDDLRALYVDRNLRLIVLKENNWSALFNIHTVEKGDLSVIA 2147
Query 2106 AINSVPWS-KILAYVKPFLGQAAITTSNCAK-------RLAQRVFNN--YMPYVFTLLFQ 2155
A S+ KIL Q A T N R+ + V N + F LL
Sbjct 2148 ASGSITRRVKILLGASSLFAQFASVTVNVTTAMGKALGRMTRNVITNTGIIGQGFALLKM 2207
Query 2156 L----CTFTKSTN-SRIRASLPTTIAKNSVKS-VAKLCLDAGINYVKSPKFSKLFTIAMW 2209
L TF KS N S ++ + V + V K C A + V KF ++ +
Sbjct 2208 LLILPFTFWKSKNQSTVKVEVGALRTAGIVTTNVVKQCASAAYD-VLVVKFKRIDWKSTL 2266
Query 2210 LLLLSIC------------------LGSLICVTAAFGVLL------SNFGAPSYCNGVRE 2245
LL IC L S + + A G+L S G S C+G+ E
Sbjct 2267 RLLFLICTTGLLLSSLYYLFLFHQVLTSDVMLDGAEGMLATYRELRSYLGIHSLCDGMVE 2326
Query 2246 LYLNSSNVTTMDFCEG-SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEW 2304
Y N S DFC S C+ CL G DSL Y A + IQ ++SY +++ + E+
Sbjct 2327 AYRNVS-YDVNDFCSNRSALCNWCLIGQDSLTRYSAFQMIQTHVTSYVINIDWVWFVMEF 2385
Query 2305 VLAYMLFTKFFYLLGLSAIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYI 2362
LAY+L+T F +L L Q FF Y + + S ++L+ V P+ +VR+Y
Sbjct 2386 ALAYVLYTSTFNVLLLVVSSQYFFSYTGAFVNWRSYNYLVSGYFFCVTHIPLLGLVRIYN 2445
Query 2363 FFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFC 2422
F A +++ + Y H+++GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG FC
Sbjct 2446 FLACLWFLRRFYNHVINGCKDTACLLCYKRNRLTRVEASTVVCGSKRTFYIVANGGTSFC 2505
Query 2423 KTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYF 2482
HNWNC++CDT G+TFI +EVA DL+ +R + PTD+S Y V+SV VK+ + L++
Sbjct 2506 CRHNWNCVDCDTAGIGNTFICEEVANDLTTSLRRLVKPTDKSHYYVESVTVKDSVVQLHY 2565
Query 2483 DKAGQKTYERHPLSHFVNLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYY 2538
+ G YER+PL +F NLD L+ G N +++D + E+ ++SA VYY
Sbjct 2566 SREGASCYERYPLCYFTNLDKLKFKEVCKTPTGIPEHNFLIYDSSDRGQENLARSACVYY 2625
Query 2539 SQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELA 2598
SQ++ +P+LL+D +V+ VGDS E++ KM D+YV++F + F V +KL LVATA +
Sbjct 2626 SQVLSKPMLLVDSNMVTTVGDSREIASKMLDSYVNSFISLFGVNRDKLDKLVATARDCVK 2685
Query 2599 KGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKV 2657
+G V+ TF AAR V++DV+T +++ L+ ++ DL++T + NN++ +Y K
Sbjct 2686 RGDDFQTVIKTFTDAARGPAGVESDVETSSIVDALQYAYKHDLQLTTEGFNNYVPSYIKP 2745
Query 2658 ENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPF 2717
+++ DLG ID NA +N ++ N + IWN DYM LS+ L++QIR A +K NIPF
Sbjct 2746 DSVATADLGCLIDLNAASVNQTSIRNANGACIWNSSDYMKLSDSLKRQIRIACRKCNIPF 2805
Query 2718 RLTCATTRQVVNVITTKIS---LKGG------KIVSTCFKLMLKATLLCVLAALVCYIVM 2768
RLT + R N+++ K S L GG K+ +K TL+ A++ Y+ +
Sbjct 2806 RLTTSRLRSADNILSVKFSATKLSGGAPKWLLKLRDFTWKSYCVVTLVVFAMAVLSYLCL 2865
Query 2769 PVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKS 2827
P +S + + I+ YK +++G+ RDI +D CFANK+ F WF++ GG + ND S
Sbjct 2866 PAFNMSQVSFHEDRILTYKVVENGIIRDITPSDTCFANKYQSFSKWFNEHYGGLFNNDIS 2925
Query 2828 CPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFAT 2887
CPV A+I G VP LP V + + F+ RVF++ N+CYTP+ I Y F+
Sbjct 2926 CPVTVAVIAGVAGARVPNLPANV-AWVGRQIVLFVSRVFASSNNVCYTPTAEIPYERFSD 2984
Query 2888 SACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYL 2946
S CVLA+ECT+F+DA GK PYCYD +L G+ +Y +++P RY + D I+FP
Sbjct 2985 SGCVLASECTLFRDAEGKINPYCYDPTVLPGASAYDQMKPHVRYDMYDSDMYIKFPEVVF 3044
Query 2947 EGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIAN 3006
E ++R+ T YCR G+CE + G+C++T+G W + N+HY GV+CG + +++
Sbjct 3045 ESTLRITKTLATRYCRFGSCEDANEGVCITTNGSWAIYNDHYANKPGVYCGDNYFDIVRR 3104
Query 3007 IFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSF 3066
+ L QPV +S S+ G ++ I +T A YY K +R +Y L++
Sbjct 3105 LGLSLFQPVTYFQLSTSLALGVMLCIFLTIAFYYVNKVKRALADYTQCAVVAVAAALLNS 3164
Query 3067 TILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCIS 3126
LC V + L Y+ Y Y TFY T + +F+ H+ WF MF +VP W+ Y+ +
Sbjct 3165 LCLCFVVSNPLLVLPYTALYYYATFYLTGEPAFVMHVSWFVMFGTVVPIWMVFAYIVGVC 3224
Query 3127 LKHCHWFFNNYLRKRV--MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRY 3184
L+H W + +K V +G +F++AA F++NK+ Y+ LR+ + YNRY
Sbjct 3225 LRHLLWVMAYFSKKHVEVFTDGKLNCSFQDAAANIFVINKDTYVALRNS--ITQDSYNRY 3282
Query 3185 LALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFR 3244
L+++NKYKY+SGA+DT SYREA+ HL KAL +S +G+DVL+QPP S+TS+VLQSG
Sbjct 3283 LSMFNKYKYYSGAMDTASYREASAAHLCKALQVYSETGSDVLFQPPNCSVTSSVLQSGLV 3342
Query 3245 KMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNH 3304
KMA PSG VE CMVQVTCG+ TLNGLWLD+ V+CPRHV+C A+ + +PNY+ LL+ K+N
Sbjct 3343 KMAAPSGVVENCMVQVTCGSMTLNGLWLDNYVWCPRHVMCPADQLSDPNYDALLVSKTNL 3402
Query 3305 SFLVQAG---NVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGS 3361
SF+VQ LRV+GH+M LL+L V+++NP+TP Y F ++PG +FSVLACYNG
Sbjct 3403 SFIVQKNVGAPANLRVVGHTMVGTLLKLTVESANPQTPAYTFTTVKPGASFSVLACYNGR 3462
Query 3362 PSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKF 3421
P+GV+ MR N TIKGSFL GSCGSVG+ + + ++FCYMH MEL G H G +G
Sbjct 3463 PTGVFMVNMRQNSTIKGSFLCGSCGSVGYTQEGNVINFCYMHQMELSNGTHTGCAFDGVM 3522
Query 3422 YGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEP 3481
YG F DRQ Q +D T+N++AWLYAA++NG WF+ T + FN AM +
Sbjct 3523 YGAFEDRQVHQVQLSDKYCTINIVAWLYAAILNGCNWFVKPNKTGIATFNEWAMSNQFTE 3582
Query 3482 LTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCS 3541
+ L+ +TG++V + A++ L G G+TILG+++LEDEFTP DV Q
Sbjct 3583 FIG--TQSVDMLAHKTGVSVEQLLYAIQTL-HKGFQGKTILGNSMLEDEFTPDDVNMQVM 3639
Query 3542 GVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAAC 3601
GV Q K+I G HW+ T L + + +Q T+++++ +++E L T ++ + AC
Sbjct 3640 GVVMQSGVKRISYGLVHWLFTTLLLAYVATLQLTKFTIWNYLFEVIPLQLTPLVLCVMAC 3699
Query 3602 AMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPA----SWVMRIMTWLELADTSLSGYRLK 3657
ML VKHKH FL LFLLP+ + Y N+VY P S ++ + WL A +
Sbjct 3700 VMLTVKHKHTFLTLFLLPTAICLTYANIVYEPQTPVSSALIAVANWLNPASVYMRTTH-T 3758
Query 3658 DCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISV 3717
D +Y S L ++ R +A+ L + + Y G+ ++ + ++
Sbjct 3759 DLGVYLSLCFALAVVVRRLYRPNASNLALALGSAMVWFYTYTTGDC-SSPLTYLMFLTTL 3817
Query 3718 TSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
TS+Y+ V + +A+ V Y P ++ ++L+Y +GY C YFG+F LL
Sbjct 3818 TSDYTVTVFLAVNVAKFFARVVFLYAPHAGFIFPEVKLVLLMYLAVGYFCTVYFGVFSLL 3877
Query 3778 NRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQS 3837
N R+ LGVYDY VSTQEFRY+ GL P++S +A +LN+KL+GIGG PCIK+A+VQS
Sbjct 3878 NLKLRVPLGVYDYTVSTQEFRYLTGNGLHAPRNSWEALRLNMKLIGIGGTPCIKIASVQS 3937
Query 3838 KMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLS 3897
K++D+KCTSVVLLSVLQQL +E++SK WA CV+LHNDIL A D TEAF+ V L + L+S
Sbjct 3938 KLTDLKCTSVVLLSVLQQLHLEANSKAWAHCVKLHNDILAATDPTEAFDNFVCLFATLMS 3997
Query 3898 MQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKK 3956
VD+ L ++LD+ + LQA SEFS L SYA AQ +Y++A+ +GD S VLK
Sbjct 3998 FSANVDLEALASDLLDHPSVLQATLSEFSHLASYAELEAAQSSYQKALNSGDASPQVLKA 4057
Query 3957 LKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRK 4016
L+K++N+AK+ +++D A+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++K
Sbjct 4058 LQKAVNIAKNAYEKDKAVARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKK 4117
Query 4017 LDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQ 4076
LDND LN +I+NAR+GCVPL+++PL + KL VV+PD + + +YA ALW+I
Sbjct 4118 LDNDVLNGVISNARNGCVPLSVVPLCASNKLRVVIPDITIWNKVVTWPSLSYAGALWDIS 4177
Query 4077 QVVDADSKIVQLSEINMDNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSCAAGT 4135
+ + D ++V+ S++ N +L WPL++ R A+SAV LQNNE+ P L+ M +AG
Sbjct 4178 LINNVDGEVVKSSDVTETN-ESLTWPLVLECTRAASSAVTLQNNEIRPSGLKTMVVSAGI 4236
Query 4136 TQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTD 4195
C + ++LAYY +G + ++ +LS++ LKWA+ DG I EL+PPC+F+
Sbjct 4237 DHANC-NTSSLAYYEPVEGRKMLMGILSENAHLKWAKVEGRDGFVNI--ELQPPCKFLIA 4293
Query 4196 TPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAK 4255
PKGP+V+YLYF+K LNNL+RG +LG +AATVRLQAG+ TE NS+VLS F+VDP K
Sbjct 4294 GPKGPEVRYLYFVKNLNNLHRGQLLGHIAATVRLQAGSNTEFAINSSVLSAVTFSVDPGK 4353
Query 4256 AYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPN 4315
AY D++ +GG P+TNCVKML TGTG A++V PEAN DQ+++GGAS CLYCR HI+HP+
Sbjct 4354 AYLDFVNAGGAPLTNCVKMLTPKTGTGIAVSVKPEANADQDTYGGASVCLYCRAHIEHPD 4413
Query 4316 PKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADAST 4375
G C KGK+VQ+P DPVGF L+NT C VC W G+GC+CD LR + + S
Sbjct 4414 VTGVCKFKGKFVQVPLH-IRDPVGFCLQNTPCNVCQFWIGHGCNCDALRGTTIPQSKDSN 4472
Query 4376 FLN 4378
FLN
Sbjct 4473 FLN 4475
>sp|P0C6T4|R1A_BCHK4 Replicase polyprotein 1a OS=Bat coronavirus
HKU4 OX=694007 GN=1a PE=1 SV=1
Length=4434
Score = 4447 bits (11533), Expect = 0.0, Method: Composition-based stats.
Identities = 1489/4550 (33%), Positives = 2279/4550 (50%), Gaps = 313/4550 (7%)
Query 8 VNEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGV 60
NEK HV ++P+ D+ L F D E A ++ LK G V + +
Sbjct 21 YNEKRSDHVACTVPLCDTDDMACKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRA 79
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGI---TLGVLVPHVGETP 115
+ L P V++ H +V +A D G R+ + LG+ P+
Sbjct 80 MKFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDQVGAAMMRTTLNAKPLGMFFPYDSSLE 139
Query 116 IAYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALRE 172
LLRKNG G D K ++ D+L DP Y QN
Sbjct 140 TGEYTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------ 187
Query 173 LTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYC 230
L ++L GG +D CG +G P+ +A+ G + ++S R +
Sbjct 188 LLKKLIGGDCIP-IDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDSDRFI-V 245
Query 231 CRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RVE 289
+ + W R + Y QT F I S + D K P+ F + S++ ++ P +
Sbjct 246 LNKKLYRVVWNVTRRNVPYPKQTAFTIVSVVQCDD-KDSVPEHTFTIGSQILMVSPLKAT 304
Query 290 KKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTEN 348
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 305 NNKNFNLKQRLLYTFYGKDAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANY 364
Query 349 LVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TRC 405
+ + G +P NA+ CP + HS A +N + + + GG+ T
Sbjct 365 SANDVDLQSSGLVPRNALFLANCPCANNGAC--SHSAAQVYNILDGKACVEVGGKSFTLT 422
Query 406 FGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRER 458
FGG V+AY+GC + Y+VPRA + I +G TG VET N L + +
Sbjct 423 FGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKAQ 478
Query 459 VNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGKP 516
++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 479 RSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDY 535
Query 517 VKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQ 576
++ A NIG V P A + F + +L+ A LD S
Sbjct 536 IRDAINIGAN-GVCNATINAPFIAFTGLGESFKKVSAIPWKICSNLKSA----LDYYSSN 590
Query 577 SLRLV-------DAMVYTSDLLTNSVIIMA---YVTGGLVQQTSQWLSNLLGTTVEKLRP 626
+ V D + LL + +A +V L ++ L + L
Sbjct 591 IMFRVFPYDIPCDVSNFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTVSSACQTALSS 650
Query 627 IFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKAL 686
A A F+ D +++ K L+ ++ +++ V+ +D+++KA+
Sbjct 651 FLNACVAASRATAGFINDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSKAM 710
Query 687 EMCIDQVTIAGAKLRSLNL--GEVFIAQSKGLYRQCIRGKE---QLQLLMPLKAPKEVTF 741
++ V+ AG KL ++ E + S + + K Q+ L++P K+
Sbjct 711 KLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQGQMNLVLPGDYNKKTLG 770
Query 742 L-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDK 796
+ D+ D S V + +G+LE P + IVG V V+ + + +D+
Sbjct 771 ILDPVPNADTIDVNANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKLFVRTEDE 826
Query 797 EQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNE 856
E Y + G + + +FRLKGG P K VTFG+ EV Y++V IT+++ +D +L+
Sbjct 827 EFYPLCTNGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLDALLSS 885
Query 857 -KCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEE 915
K + +TVE V +F V+ + V+ L P+ G D++++ Y+++ G+
Sbjct 886 SKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDGDC 945
Query 916 NFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEE 975
+SS M S P ++ EE + E++ + + E DD + + + E V
Sbjct 946 AWSSNMTFSINPVEDVEEVEEFIEDDYLSD----ELPIADDEEA----WARAVEEVMP-- 995
Query 976 EEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVI 1035
D +EIE E +P E + + T V+ + S + +V
Sbjct 996 -------LDDILVAEIELEEDPPLETALESVEAEVVETAEAQEPSVESIDSTPSTSTVVG 1048
Query 1036 VNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHV 1095
N ++ +K VA E+DD ++L + VG
Sbjct 1049 EN--DLSVKPMSRVA-------------ETDDVLELETAV-VG----------------- 1075
Query 1096 VGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAV 1155
GP + + + + G+ + QV
Sbjct 1076 -GP----------VSDVTAIVTNDIVSVEQAQQCGVSSLPIQ---DEASENQVHQVSDLQ 1121
Query 1156 NDKALYEQVVMDYLD---NLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACI 1212
++ L + ++ + +LKPR + K + + SV D
Sbjct 1122 GNELLCSETKVEIVQPRQDLKPR-RSRKSKVDLSKYKHTVINNSVTLVLGDAIQIASLLP 1180
Query 1213 DEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS--- 1269
+ I G + S ++ E ++ + P VGD +
Sbjct 1181 KCILVNAANRHLKHG-----GGIAGVINKASGGDVQEESDEYISNNGPLHVGDSVLLKGH 1235
Query 1270 ---GDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCK 1326
I VV P + +L R K +++ AG + K + +
Sbjct 1236 GLADAILHVVGPDARNNEDAALLKRCYKAF--NKHTIVVTPLISAGIFSVDPKVSFEYLL 1293
Query 1327 SAF-----------YVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIM 1375
+ + + A +K + L R + A+ IC + A +
Sbjct 1294 ANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANV 1353
Query 1376 ATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNL 1435
++ K + VD GV ++ Y++++ + +I N + + MP GYVTHG +L
Sbjct 1354 KFLRTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCS-GICAMPFGYVTHGLDL 1411
Query 1436 EEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SG 1494
++ +R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1412 AQSGNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSG 1469
Query 1495 QRTELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK-- 1543
V + K G I Y + +++ V L+ ++ L+ R +
Sbjct 1470 DLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQV 1525
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDT 1603
I+V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +
Sbjct 1526 NIEVLVTIDGVNFRTVILNDTTTFRKQLGATFYKGVDISDAFPTVKMGGESLFVADNLSE 1585
Query 1604 LRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ +
Sbjct 1586 SEKVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDM 1645
Query 1663 L-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-S 1720
L ++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L S
Sbjct 1646 LHDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVS 1705
Query 1721 AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
AK V C CG + TG+ A +Y G S + L++ + CVCG + LV+ +
Sbjct 1706 AKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSAP 1765
Query 1781 FVMMSAPPAEYKLQQG--TFLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
++++S + N + G GHY HI K+ L Y+ D LTK S+
Sbjct 1766 WLLVSGLNEVKVSTSTDPIYRAFNVFQGVETSVGHYVHIRVKDGLFYKYDSGSLTKTSDM 1825
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1826 KCKMTSVWYPTVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1885
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1886 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1945
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1946 FSNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2005
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVK---TTEVVGNVILKPSDEGVKVTQ 2065
+Q E P ++V P +++IE K V GN GV V
Sbjct 2006 TSQ-----LVEHNVPVVDDV---PITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2057
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG---IAAINSVPWS-KILAYVK 2120
LG +L A YV+ NT + + N S L T+ + +AA SV ++L
Sbjct 2058 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVESGDLQIVAAGGSVTRRARVLLGAS 2117
Query 2121 PFLGQAAITTSNCAK-------RLAQRVFNNY---------MPYVFTLLFQLCTFTKSTN 2164
A T R + NY + +F L F K
Sbjct 2118 SLFASFAKITVTATTAACKTAGRGFCKFVVNYGVLQNMFVFLKMLFFLPFNYLWPKKQPT 2177
Query 2165 SRIRASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTI-------------AM 2208
I S T + N VK + K + +
Sbjct 2178 VDIGVSGLRTAGIVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLLSSIY 2237
Query 2209 WLLLLSICLGSLICVTAAFGVLL------SNFGAPSYCNGVRELYLNSSNVTTMDFCEG- 2261
L+L + L S + + A G+L S G + C+G+ Y N+S M+FC
Sbjct 2238 HLVLFNQVLSSDVMLEDATGILAIYKEVRSYLGIRTLCDGLVVEYRNTS-FDVMEFCSNR 2296
Query 2262 SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLS 2321
S C CL G DSL Y AL+ +Q I+SY L++ + A E+ LAY+L+T F +L L
Sbjct 2297 SVLCQWCLIGQDSLTRYSALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLV 2356
Query 2322 AIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
Q FF Y ++ + + ++++ + +V P+ +VR+Y F A +++ K Y H+++
Sbjct 2357 VTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHGLVRVYNFLACLWFLRKFYSHVIN 2416
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC + C++CYKRNR TRVE +TIV G KR+FY+ ANGG +C HNWNC+ CDT G+
Sbjct 2417 GCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAGVGN 2476
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI EVA DL+ +R I PTDQS Y VDSV VK+ + L++++ G YER+PL +F
Sbjct 2477 TFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFT 2536
Query 2500 NLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
NL+ L+ G N +++D + E+ ++SA VYYSQ++C+P+LL+D LV+
Sbjct 2537 NLEKLKFKEVCKTPTGIPEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVT 2596
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VGDS E+++KM D+++++F + FSV +KL+ L+ TA + +G VL TF AAR
Sbjct 2597 TVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINTARDCVRRGDDFQNVLKTFTDAAR 2656
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
V++DV+T V++ L+ +H +D+++T + NN++ Y K +++ DLG ID A
Sbjct 2657 GHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDLKAA 2716
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
+N ++ N + +WN DYM LS+ ++QIR A +K NIPFRLT + R N+++ K
Sbjct 2717 SVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVK 2776
Query 2735 ISLKG--GKIVSTCF-------KLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIG 2785
S G S K TL A++ + +P ++++ + + I+
Sbjct 2777 FSATKIVGGAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILT 2836
Query 2786 YKAIQDGVTRDIISTDDCFANKHAGFDAWF-SQRGGSYKNDKSCPVVAAIITREIGFIVP 2844
YK I++G+ RDI D CFANK+ F WF GG Y+N CP+ A+I G V
Sbjct 2837 YKVIENGIVRDIAPNDVCFANKYGHFSKWFNENHGGVYRNSMDCPITIAVIAGVAGARVA 2896
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P L + + F+ RVF+ N+C+TP I Y F+ S CVL++ECT+F+DA G
Sbjct 2897 NVPAN-LAWVGKQIVLFVSRVFANT-NVCFTPINEIPYDTFSDSGCVLSSECTLFRDAEG 2954
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P+CYD +L G+ SY++++P RY + D I+FP +E ++R+ T +YCR
Sbjct 2955 NLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIVESTLRITKTLATQYCRF 3014
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G+CE S G+C+ST+G W L N++Y G++CG D +++ + L QPV +S S
Sbjct 3015 GSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAISLFQPVTYFQLSTS 3074
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
+ G ++ + +T A YY K +R +Y + L++ LC + A L Y+
Sbjct 3075 LAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCLCFIVANPLLVAPYT 3134
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV- 3142
Y Y TFY T + +F+ H+ W+ MF +VP W+ A Y + L+H W + +K V
Sbjct 3135 AMYYYATFYLTGEPAFIMHISWYVMFGAVVPIWMLASYTVGVMLRHLFWVLAYFSKKHVD 3194
Query 3143 -MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTT 3201
+G +F++AA F++ K+ Y+ LR+ + + RYL+L+NKYKY+SGA+DT
Sbjct 3195 VFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRYLSLFNKYKYYSGAMDTA 3252
Query 3202 SYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
SYREA HL KAL +S +G+D+LYQPP S+TS+VLQSG KM+ PSG VE C+VQVT
Sbjct 3253 SYREACAAHLCKALQTYSETGSDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVT 3312
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVI 3318
CG+ TLNGLWLD+TV+CPRH++C A+ + +PNY+ LLI K+NHSF+VQ LRV+
Sbjct 3313 CGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKTNHSFIVQKHIGAQANLRVV 3372
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
HSM LL+L VD +NP TP Y F ++PG +FSVLACYNG P+GV+ +R N TIKG
Sbjct 3373 AHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKG 3432
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ + ++F YMH MEL G H G+ +G YG F D+QT Q TD
Sbjct 3433 SFLCGSCGSVGYTENGGVINFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDK 3492
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
T+NV+AWLYAAV+NG +WF+ + +N A+ + + L+ +TG
Sbjct 3493 YCTINVVAWLYAAVLNGCKWFVKPTRVGIVTYNEWALSNQFTEFVG--TQSIDMLAHRTG 3550
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
++V M AA++ L G G+TILG + LEDEFTP DV Q GV Q K+I G H
Sbjct 3551 VSVEQMLAAIQSL-HAGFQGKTILGQSTLEDEFTPDDVNMQVMGVVMQSGVKRISYGFIH 3609
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ TF+ + + ++Q T+++++ +++E T ++ AC M VKHKH F+ LFLL
Sbjct 3610 WLISTFVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLLGFMACVMFTVKHKHTFMSLFLL 3669
Query 3619 PSLATVAYFNMVYMPASW----VMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTA 3674
P + Y N+VY P + ++ + WL + D +Y S +L ++
Sbjct 3670 PVALCLTYANIVYEPQTLISSTLIAVANWLTPTSVYMRTTHF-DFGLYISLSFVLAIIVR 3728
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R + L + + Y G+ I+ + ++TS+Y+ V + LA+
Sbjct 3729 RLYRPSMSNLALALCSGVMWFYTYVIGDH-SSPITYLMFITTLTSDYTITVFATVNLAKF 3787
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
I + Y P L ++ ++L+Y LGY C YFG+F LLN R+ LGVYDY VST
Sbjct 3788 ISGLVFFYAPHLGFILPEVKLVLLIYLGLGYMCTMYFGVFSLLNLKLRVPLGVYDYSVST 3847
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
QEFR++ GL P++S +A LN KLLGIGG PCIKVATVQSK++D+KCTSVVLL+VLQ
Sbjct 3848 QEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQ 3907
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
QL +ES+SK W+ CV+LHN+IL A D TEAFE+ V L + L+S VD++ L ++ +N
Sbjct 3908 QLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFEN 3967
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAA 3973
+ LQA +EFS L +YA TAQ +Y++A+ +GD S VLK L+K++NVAK+ +++D A
Sbjct 3968 SSVLQATLTEFSHLATYAELETAQSSYQKALNSGDASPQVLKALQKAVNVAKNAYEKDKA 4027
Query 3974 MQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGC 4033
+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN +I NAR+GC
Sbjct 4028 VARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGC 4087
Query 4034 VPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINM 4093
VPL+I+PL + KL VV+PD + + + +YA +LW+I + + D+++V+ +++
Sbjct 4088 VPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDITVINNVDNEVVKPTDVVE 4147
Query 4094 DNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNS 4152
N +L WPL++ R ++SAVKLQNNE+ P L+ M AG Q C + +A+AYY
Sbjct 4148 TN-ESLTWPLVIECSRSSSSAVKLQNNEIHPKGLKTMVITAGVDQVNC-NSSAVAYYEPV 4205
Query 4153 KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLN 4212
+G R V+ LLS++ LKWA+ DG I EL+PPC+F+ PKGP+++YLYF+K LN
Sbjct 4206 QGHRMVMGLLSENAHLKWAKVEGKDGF--INIELQPPCKFLIAGPKGPEIRYLYFVKNLN 4263
Query 4213 NLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCV 4272
NL+RG +LG +AATVRLQAG TE +NSTVL+ AFAVDPAKAY DY+ SGG P++N V
Sbjct 4264 NLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYV 4323
Query 4273 KMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTT 4332
KML TGTG AI+V PEA DQE++GGAS CLYCR HI+HP+ G C K ++VQIP
Sbjct 4324 KMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAH 4383
Query 4333 CANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
DPVGF L+N C VC W GYGC+CD LR + + + FLN V
Sbjct 4384 -VRDPVGFLLKNVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLNESGV 4432
>sp|P0C6W3|R1AB_BCHK4 Replicase polyprotein 1ab OS=Bat coronavirus
HKU4 OX=694007 GN=rep PE=1 SV=1
Length=7119
Score = 4446 bits (11532), Expect = 0.0, Method: Composition-based stats.
Identities = 1488/4546 (33%), Positives = 2278/4546 (50%), Gaps = 313/4546 (7%)
Query 8 VNEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGV 60
NEK HV ++P+ D+ L F D E A ++ LK G V + +
Sbjct 21 YNEKRSDHVACTVPLCDTDDMACKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRA 79
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGI---TLGVLVPHVGETP 115
+ L P V++ H +V +A D G R+ + LG+ P+
Sbjct 80 MKFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDQVGAAMMRTTLNAKPLGMFFPYDSSLE 139
Query 116 IAYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALRE 172
LLRKNG G D K ++ D+L DP Y QN
Sbjct 140 TGEYTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------ 187
Query 173 LTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYC 230
L ++L GG +D CG +G P+ +A+ G + ++S R +
Sbjct 188 LLKKLIGGDCIP-IDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDSDRFI-V 245
Query 231 CRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RVE 289
+ + W R + Y QT F I S + D K P+ F + S++ ++ P +
Sbjct 246 LNKKLYRVVWNVTRRNVPYPKQTAFTIVSVVQCDD-KDSVPEHTFTIGSQILMVSPLKAT 304
Query 290 KKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTEN 348
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 305 NNKNFNLKQRLLYTFYGKDAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANY 364
Query 349 LVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TRC 405
+ + G +P NA+ CP + HS A +N + + + GG+ T
Sbjct 365 SANDVDLQSSGLVPRNALFLANCPCANNGAC--SHSAAQVYNILDGKACVEVGGKSFTLT 422
Query 406 FGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRER 458
FGG V+AY+GC + Y+VPRA + I +G TG VET N L + +
Sbjct 423 FGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKAQ 478
Query 459 VNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGKP 516
++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 479 RSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDY 535
Query 517 VKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQ 576
++ A NIG V P A + F + +L+ A LD S
Sbjct 536 IRDAINIGAN-GVCNATINAPFIAFTGLGESFKKVSAIPWKICSNLKSA----LDYYSSN 590
Query 577 SLRLV-------DAMVYTSDLLTNSVIIMA---YVTGGLVQQTSQWLSNLLGTTVEKLRP 626
+ V D + LL + +A +V L ++ L + L
Sbjct 591 IMFRVFPYDIPCDVSNFVELLLDCGKLTVATSYFVLRYLDEKFDTVLGTVSSACQTALSS 650
Query 627 IFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKAL 686
A A F+ D +++ K L+ ++ +++ V+ +D+++KA+
Sbjct 651 FLNACVAASRATAGFINDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSKAM 710
Query 687 EMCIDQVTIAGAKLRSLNL--GEVFIAQSKGLYRQCIRGKE---QLQLLMPLKAPKEVTF 741
++ V+ AG KL ++ E + S + + K Q+ L++P K+
Sbjct 711 KLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQGQMNLVLPGDYNKKTLG 770
Query 742 L-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDK 796
+ D+ D S V + +G+LE P + IVG V V+ + + +D+
Sbjct 771 ILDPVPNADTIDVNANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKLFVRTEDE 826
Query 797 EQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNE 856
E Y + G + + +FRLKGG P K VTFG+ EV Y++V IT+++ +D +L+
Sbjct 827 EFYPLCTNGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLDALLSS 885
Query 857 -KCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEE 915
K + +TVE V +F V+ + V+ L P+ G D++++ Y+++ G+
Sbjct 886 SKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDGDC 945
Query 916 NFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEE 975
+SS M S P ++ EE + E++ + + E DD + + + E V
Sbjct 946 AWSSNMTFSINPVEDVEEVEEFIEDDYLSD----ELPIADDEEA----WARAVEEVMP-- 995
Query 976 EEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVI 1035
D +EIE E +P E + + T V+ + S + +V
Sbjct 996 -------LDDILVAEIELEEDPPLETALESVEAEVVETAEAQEPSVESIDSTPSTSTVVG 1048
Query 1036 VNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHV 1095
N ++ +K VA E+DD ++L + VG
Sbjct 1049 EN--DLSVKPMSRVA-------------ETDDVLELETAV-VG----------------- 1075
Query 1096 VGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAV 1155
GP + + + + G+ + QV
Sbjct 1076 -GP----------VSDVTAIVTNDIVSVEQAQQCGVSSLPIQ---DEASENQVHQVSDLQ 1121
Query 1156 NDKALYEQVVMDYLD---NLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACI 1212
++ L + ++ + +LKPR + K + + SV D
Sbjct 1122 GNELLCSETKVEIVQPRQDLKPR-RSRKSKVDLSKYKHTVINNSVTLVLGDAIQIASLLP 1180
Query 1213 DEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS--- 1269
+ I G + S ++ E ++ + P VGD +
Sbjct 1181 KCILVNAANRHLKHG-----GGIAGVINKASGGDVQEESDEYISNNGPLHVGDSVLLKGH 1235
Query 1270 ---GDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCK 1326
I VV P + +L R K +++ AG + K + +
Sbjct 1236 GLADAILHVVGPDARNNEDAALLKRCYKAF--NKHTIVVTPLISAGIFSVDPKVSFEYLL 1293
Query 1327 SAF-----------YVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIM 1375
+ + + A +K + L R + A+ IC + A +
Sbjct 1294 ANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANV 1353
Query 1376 ATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNL 1435
++ K + VD GV ++ Y++++ + +I N + + MP GYVTHG +L
Sbjct 1354 KFLRTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCS-GICAMPFGYVTHGLDL 1411
Query 1436 EEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SG 1494
++ +R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1412 AQSGNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSG 1469
Query 1495 QRTELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK-- 1543
V + K G I Y + +++ V L+ ++ L+ R +
Sbjct 1470 DLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQV 1525
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDT 1603
I+V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +
Sbjct 1526 NIEVLVTIDGVNFRTVILNDTTTFRKQLGATFYKGVDISDAFPTVKMGGESLFVADNLSE 1585
Query 1604 LRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ +
Sbjct 1586 SEKVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDM 1645
Query 1663 L-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-S 1720
L ++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L S
Sbjct 1646 LHDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVS 1705
Query 1721 AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
AK V C CG + TG+ A +Y G S + L++ + CVCG + LV+ +
Sbjct 1706 AKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSAP 1765
Query 1781 FVMMSAPPAEYKLQQG--TFLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
++++S + N + G GHY HI K+ L Y+ D LTK S+
Sbjct 1766 WLLVSGLNEVKVSTSTDPIYRAFNVFQGVETSVGHYVHIRVKDGLFYKYDSGSLTKTSDM 1825
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1826 KCKMTSVWYPTVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1885
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1886 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1945
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1946 FSNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2005
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVK---TTEVVGNVILKPSDEGVKVTQ 2065
+Q E P ++V P +++IE K V GN GV V
Sbjct 2006 TSQ-----LVEHNVPVVDDV---PITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2057
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHG---IAAINSVPWS-KILAYVK 2120
LG +L A YV+ NT + + N S L T+ + +AA SV ++L
Sbjct 2058 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVESGDLQIVAAGGSVTRRARVLLGAS 2117
Query 2121 PFLGQAAITTSNCAK-------RLAQRVFNNY---------MPYVFTLLFQLCTFTKSTN 2164
A T R + NY + +F L F K
Sbjct 2118 SLFASFAKITVTATTAACKTAGRGFCKFVVNYGVLQNMFVFLKMLFFLPFNYLWPKKQPT 2177
Query 2165 SRIRASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTI-------------AM 2208
I S T + N VK + K + +
Sbjct 2178 VDIGVSGLRTAGIVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLLSSIY 2237
Query 2209 WLLLLSICLGSLICVTAAFGVLL------SNFGAPSYCNGVRELYLNSSNVTTMDFCEG- 2261
L+L + L S + + A G+L S G + C+G+ Y N+S M+FC
Sbjct 2238 HLVLFNQVLSSDVMLEDATGILAIYKEVRSYLGIRTLCDGLVVEYRNTS-FDVMEFCSNR 2296
Query 2262 SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLS 2321
S C CL G DSL Y AL+ +Q I+SY L++ + A E+ LAY+L+T F +L L
Sbjct 2297 SVLCQWCLIGQDSLTRYSALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLV 2356
Query 2322 AIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
Q FF Y ++ + + ++++ + +V P+ +VR+Y F A +++ K Y H+++
Sbjct 2357 VTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHGLVRVYNFLACLWFLRKFYSHVIN 2416
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC + C++CYKRNR TRVE +TIV G KR+FY+ ANGG +C HNWNC+ CDT G+
Sbjct 2417 GCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAGVGN 2476
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI EVA DL+ +R I PTDQS Y VDSV VK+ + L++++ G YER+PL +F
Sbjct 2477 TFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFT 2536
Query 2500 NLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
NL+ L+ G N +++D + E+ ++SA VYYSQ++C+P+LL+D LV+
Sbjct 2537 NLEKLKFKEVCKTPTGIPEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVT 2596
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VGDS E+++KM D+++++F + FSV +KL+ L+ TA + +G VL TF AAR
Sbjct 2597 TVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINTARDCVRRGDDFQNVLKTFTDAAR 2656
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
V++DV+T V++ L+ +H +D+++T + NN++ Y K +++ DLG ID A
Sbjct 2657 GHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDLKAA 2716
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
+N ++ N + +WN DYM LS+ ++QIR A +K NIPFRLT + R N+++ K
Sbjct 2717 SVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVK 2776
Query 2735 ISLKG--GKIVSTCF-------KLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIG 2785
S G S K TL A++ + +P ++++ + + I+
Sbjct 2777 FSATKIVGGAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILT 2836
Query 2786 YKAIQDGVTRDIISTDDCFANKHAGFDAWF-SQRGGSYKNDKSCPVVAAIITREIGFIVP 2844
YK I++G+ RDI D CFANK+ F WF GG Y+N CP+ A+I G V
Sbjct 2837 YKVIENGIVRDIAPNDVCFANKYGHFSKWFNENHGGVYRNSMDCPITIAVIAGVAGARVA 2896
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P L + + F+ RVF+ N+C+TP I Y F+ S CVL++ECT+F+DA G
Sbjct 2897 NVPAN-LAWVGKQIVLFVSRVFANT-NVCFTPINEIPYDTFSDSGCVLSSECTLFRDAEG 2954
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P+CYD +L G+ SY++++P RY + D I+FP +E ++R+ T +YCR
Sbjct 2955 NLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIVESTLRITKTLATQYCRF 3014
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G+CE S G+C+ST+G W L N++Y G++CG D +++ + L QPV +S S
Sbjct 3015 GSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAISLFQPVTYFQLSTS 3074
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
+ G ++ + +T A YY K +R +Y + L++ LC + A L Y+
Sbjct 3075 LAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCLCFIVANPLLVAPYT 3134
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV- 3142
Y Y TFY T + +F+ H+ W+ MF +VP W+ A Y + L+H W + +K V
Sbjct 3135 AMYYYATFYLTGEPAFIMHISWYVMFGAVVPIWMLASYTVGVMLRHLFWVLAYFSKKHVD 3194
Query 3143 -MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTT 3201
+G +F++AA F++ K+ Y+ LR+ + + RYL+L+NKYKY+SGA+DT
Sbjct 3195 VFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRYLSLFNKYKYYSGAMDTA 3252
Query 3202 SYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
SYREA HL KAL +S +G+D+LYQPP S+TS+VLQSG KM+ PSG VE C+VQVT
Sbjct 3253 SYREACAAHLCKALQTYSETGSDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVT 3312
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVI 3318
CG+ TLNGLWLD+TV+CPRH++C A+ + +PNY+ LLI K+NHSF+VQ LRV+
Sbjct 3313 CGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKTNHSFIVQKHIGAQANLRVV 3372
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
HSM LL+L VD +NP TP Y F ++PG +FSVLACYNG P+GV+ +R N TIKG
Sbjct 3373 AHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKG 3432
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ + ++F YMH MEL G H G+ +G YG F D+QT Q TD
Sbjct 3433 SFLCGSCGSVGYTENGGVINFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDK 3492
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
T+NV+AWLYAAV+NG +WF+ + +N A+ + + L+ +TG
Sbjct 3493 YCTINVVAWLYAAVLNGCKWFVKPTRVGIVTYNEWALSNQFTEFVG--TQSIDMLAHRTG 3550
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
++V M AA++ L G G+TILG + LEDEFTP DV Q GV Q K+I G H
Sbjct 3551 VSVEQMLAAIQSL-HAGFQGKTILGQSTLEDEFTPDDVNMQVMGVVMQSGVKRISYGFIH 3609
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ TF+ + + ++Q T+++++ +++E T ++ AC M VKHKH F+ LFLL
Sbjct 3610 WLISTFVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLLGFMACVMFTVKHKHTFMSLFLL 3669
Query 3619 PSLATVAYFNMVYMPASW----VMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTA 3674
P + Y N+VY P + ++ + WL + D +Y S +L ++
Sbjct 3670 PVALCLTYANIVYEPQTLISSTLIAVANWLTPTSVYMRTTHF-DFGLYISLSFVLAIIVR 3728
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R + L + + Y G+ I+ + ++TS+Y+ V + LA+
Sbjct 3729 RLYRPSMSNLALALCSGVMWFYTYVIGDH-SSPITYLMFITTLTSDYTITVFATVNLAKF 3787
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
I + Y P L ++ ++L+Y LGY C YFG+F LLN R+ LGVYDY VST
Sbjct 3788 ISGLVFFYAPHLGFILPEVKLVLLIYLGLGYMCTMYFGVFSLLNLKLRVPLGVYDYSVST 3847
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
QEFR++ GL P++S +A LN KLLGIGG PCIKVATVQSK++D+KCTSVVLL+VLQ
Sbjct 3848 QEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQ 3907
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
QL +ES+SK W+ CV+LHN+IL A D TEAFE+ V L + L+S VD++ L ++ +N
Sbjct 3908 QLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFEN 3967
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAA 3973
+ LQA +EFS L +YA TAQ +Y++A+ +GD S VLK L+K++NVAK+ +++D A
Sbjct 3968 SSVLQATLTEFSHLATYAELETAQSSYQKALNSGDASPQVLKALQKAVNVAKNAYEKDKA 4027
Query 3974 MQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGC 4033
+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN +I NAR+GC
Sbjct 4028 VARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGC 4087
Query 4034 VPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINM 4093
VPL+I+PL + KL VV+PD + + + +YA +LW+I + + D+++V+ +++
Sbjct 4088 VPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDITVINNVDNEVVKPTDVVE 4147
Query 4094 DNSPNLAWPLIVTALR-ANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNS 4152
N +L WPL++ R ++SAVKLQNNE+ P L+ M AG Q C + +A+AYY
Sbjct 4148 TN-ESLTWPLVIECSRSSSSAVKLQNNEIHPKGLKTMVITAGVDQVNC-NSSAVAYYEPV 4205
Query 4153 KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLN 4212
+G R V+ LLS++ LKWA+ DG I EL+PPC+F+ PKGP+++YLYF+K LN
Sbjct 4206 QGHRMVMGLLSENAHLKWAKVEGKDGF--INIELQPPCKFLIAGPKGPEIRYLYFVKNLN 4263
Query 4213 NLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCV 4272
NL+RG +LG +AATVRLQAG TE +NSTVL+ AFAVDPAKAY DY+ SGG P++N V
Sbjct 4264 NLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYV 4323
Query 4273 KMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTT 4332
KML TGTG AI+V PEA DQE++GGAS CLYCR HI+HP+ G C K ++VQIP
Sbjct 4324 KMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAH 4383
Query 4333 CANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
DPVGF L+N C VC W GYGC+CD LR + + + FLN
Sbjct 4384 -VRDPVGFLLKNVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLN 4428
>sp|P0C6W1|R1AB_BC133 Replicase polyprotein 1ab OS=Bat coronavirus
133/2005 OX=389230 GN=rep PE=3 SV=1
Length=7126
Score = 4435 bits (11503), Expect = 0.0, Method: Composition-based stats.
Identities = 1469/4546 (32%), Positives = 2267/4546 (50%), Gaps = 306/4546 (7%)
Query 8 VNEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGV 60
NEK HV ++P+ D+ L F D E A ++ LK G V + +
Sbjct 21 YNEKRSDHVACTVPLCDTEDMASKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRA 79
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGI---TLGVLVPHVGETP 115
+ L P V++ H +V +A D G R+ + LG+ P+
Sbjct 80 MKFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDHVGAAMMRTTLNVKPLGMFFPYDSSLE 139
Query 116 IAYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALRE 172
LLRKNG G D K ++ D+L DP Y QN
Sbjct 140 TGEHTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------ 187
Query 173 LTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYC 230
L ++L GG VD CG +G P+ +A+ G + ++S R +
Sbjct 188 LLKKLIGGDCIP-VDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDSDRFI-V 245
Query 231 CRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RVE 289
+ + W R + Y QT F + S + D K P+ F + S++ ++ P +
Sbjct 246 LNKKLYRVVWNVTRRNVPYSKQTAFTVVSVIQCDD-KESVPEHTFTIGSQILMVSPLKAT 304
Query 290 KKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTEN 348
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 305 NNKNFNLKQRLLHTFYGKEAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANY 364
Query 349 LVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TRC 405
+ + G +P NA+ CP + H+ A ++ + + + GG+ T
Sbjct 365 SANDVDLQSSGLVPKNALFLANCPCANNGAC--SHNAAQVYSILDGKACVEVGGKSFTLT 422
Query 406 FGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRER 458
FGG V+AY+GC + Y+VPRA + I +G TG VET N L + +
Sbjct 423 FGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKAQ 478
Query 459 VNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGKP 516
++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 479 HSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDY 535
Query 517 VKGAWNIGQQ----RSVLTPLCGFPS------QAAGVIRSIFARTLDAANHSIPDLQRAA 566
++ A NIG ++ P F + A + I + A ++ ++
Sbjct 536 IRDAINIGANGVCNATINAPFIAFTGLGESFKKVAAIPWKICSNLKSALDYYCSNIMFRV 595
Query 567 V--TILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKL 624
I +++ L+D T V +V L ++ L + L
Sbjct 596 FPYDIPCDVNDFVELLLDCGKLT-------VATSYFVLRYLDEKFDTVLGTVSNACQTAL 648
Query 625 RPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNK 684
A A F+ D +++ K L+ ++ +++ V+ +D+++K
Sbjct 649 SSFLNACVAASRATAGFISDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSK 708
Query 685 ALEMCIDQVTIAGAKLRSLNL--GEVFIAQSKGLYRQCIRGK---EQLQLLMPLKAPKEV 739
A+++ V+ AG KL ++ E + S + + K +Q+ L++P K+
Sbjct 709 AMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQDQMNLVLPGDYNKKT 768
Query 740 TFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIK 794
+ D+ D S V + +G+LE P + IVG V V+ + +
Sbjct 769 LGILDPVPNADTIDVTANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKLFVRTD 824
Query 795 DKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL 854
D+E Y G + + +FRLKGG P K VTFG+ EV Y++V IT+++ +D +L
Sbjct 825 DEEFYPLCINGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLDALL 883
Query 855 NE-KCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAG 913
+ K + +TVE V +F V+ + V+ L P+ G D++++ Y+++ G
Sbjct 884 SSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDG 943
Query 914 EENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRV 973
+ +SS M S P ++ EE + E++ + + E DD + + + E V
Sbjct 944 DCAWSSNMTFSINPVEDVEEVEEFIEDDYLSD----ELPIADDEEA----WTRAVEEVMP 995
Query 974 EEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPM 1033
++ ++ E +E E E + L + + + + + +
Sbjct 996 LDDILVAEIELE-EDLPLETALESVEAEVGESISDELCVVETAKAQEPSVESTDSTPSTS 1054
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLT-VGGSCLLSGHNLAKKC 1092
+V+ ++ +K VA T ++ E+ GP++ V S +
Sbjct 1055 TVVSENDLSVKPMSRVAE-----TGDVLEVETAVV---GGPVSDVTASVVT--------- 1097
Query 1093 LHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVY 1152
DI ++ A + G+ + QV
Sbjct 1098 -----------NDIVSVEQAQQ--------------CGVSSLPIQ---DEASENQVHQVP 1129
Query 1153 IAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACI 1212
++V D R+ K + + SV D
Sbjct 1130 DLQCTSETKVEIVQPRQDLRPRRLR--KSKVDLSKYKHTVINNSVTLVLGDAIQIASLLP 1187
Query 1213 DEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS--- 1269
V I G + S ++ E ++ P VGD +
Sbjct 1188 KCVLVNAANRHLKHG-----GGIAGAINKASGGDVQEESDEYISNSGPLHVGDSVLLKGY 1242
Query 1270 ---GDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCK 1326
I VV P + +L R K +++ +G + K + +
Sbjct 1243 GLADAILRVVGPDARNNEDAALLKRCYKTF--NKHTIVVTPLISSGIFSVDPKVSFEYLL 1300
Query 1327 SAF-----------YVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIM 1375
+ + + A +K + L R + A+ IC + A +
Sbjct 1301 ANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANV 1360
Query 1376 ATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNL 1435
++ K + VD GV ++ Y++++ + +I N + MP GYVTHG +L
Sbjct 1361 KFLRTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCP-GICAMPFGYVTHGLDL 1418
Query 1436 EEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SG 1494
++ +R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1419 AQSGNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSG 1476
Query 1495 QRTELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK-- 1543
V + K G I Y + +++ V L+ ++ L+ R +
Sbjct 1477 DLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQV 1532
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDT 1603
I+V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +
Sbjct 1533 NIEVLVTIDGVNFRTVILNDATTFRKQLGATFYKGVDISDALPTVKMGGESLFVADNLSE 1592
Query 1604 LRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ +
Sbjct 1593 SEEVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDM 1652
Query 1663 L-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-S 1720
L ++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L S
Sbjct 1653 LHDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVS 1712
Query 1721 AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
AK V C CG + TG+ A +Y G S + L++ + CVCG + LV+ +
Sbjct 1713 AKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSTP 1772
Query 1781 FVMMSAPPAEYKLQQG--TFLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
++++S + N + G GHY H+ K+ L Y+ D LTK S+
Sbjct 1773 WLLVSGLNEVKVSTSTDPVYRAFNVFQGVETSVGHYVHVRVKDGLFYKYDSGSLTKTSDM 1832
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y + YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1833 KCKMTSVWYPKVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1892
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1893 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1952
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1953 FNNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2012
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVK---TTEVVGNVILKPSDEGVKVTQ 2065
+Q E P E+V +++IE K V GN GV V
Sbjct 2013 TSQ-----LIEPNVPVVEDVS---ITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2064
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHGIAAI---NSVPWS-KILAYVK 2120
LG +L A YV+ NT + + N S L T+ + + + SV ++L
Sbjct 2065 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVESGDLQIVANGGSVTRRARVLLGAS 2124
Query 2121 PFLGQAAITTSNCAKRLAQRVFNNYMPYVFTL----------------LFQLCTFTKSTN 2164
A T + ++ +V F K
Sbjct 2125 SLFASFAKITVTATTAACKTAGRSFCKFVVNYGVLQNMFLFLKMLFFLPFNYLWPKKQPT 2184
Query 2165 SRIRASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTI-------------AM 2208
+ S T + N VK + K + +
Sbjct 2185 VDVGVSGLRTAGVVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLLSSIY 2244
Query 2209 WLLLLSICLGSLICVTAAFGVLL------SNFGAPSYCNGVRELYLNSSNVTTMDFCEG- 2261
L++ + L S + + A G+L S G + C+G+ Y N+S +DFC
Sbjct 2245 HLVIFNQVLSSDVMLEDATGILAMYKEVRSYLGIRTLCDGLAVEYRNTS-FDVVDFCSNR 2303
Query 2262 SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLS 2321
S C CL G DSL Y AL+ +Q I+SY L++ + A E+ LAY+L+T F +L L
Sbjct 2304 SVLCQWCLIGQDSLTRYSALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLV 2363
Query 2322 AIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
Q FF Y ++ + + ++++ + +V P+ +VR+Y F A +++ K Y H+++
Sbjct 2364 VTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHGLVRVYNFLACLWFLRKFYSHVIN 2423
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC + C++CYKRNR TRVE +TIV G KR+FY+ ANGG +C HNWNC+ CDT G+
Sbjct 2424 GCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAGVGN 2483
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI EVA DL+ +R I PTDQS Y VDSV VK+ + L++++ G YER+PL +F
Sbjct 2484 TFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFT 2543
Query 2500 NLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
NL+ L+ G N +++D + E+ ++SA VYYSQ++C+P+LL+D LV+
Sbjct 2544 NLEKLKFKEVCKTPTGIPEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVT 2603
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VGDS E+++KM D+++++F + FSV +KL+ L+ TA + +G VL TF AAR
Sbjct 2604 TVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINTARDCVRRGDDFQTVLKTFTDAAR 2663
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
V++DV+T V++ L+ +H +D+++T + NN++ Y K +++ DLG ID A
Sbjct 2664 GHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDLKAA 2723
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
+N ++ N + +WN DYM LS+ ++QIR A +K NIPFRLT + R N+++ K
Sbjct 2724 SVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVK 2783
Query 2735 ISLKG--GKIVSTCF-------KLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIG 2785
S G S K TL A++ + +P ++++ + + I+
Sbjct 2784 FSATKIVGGAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILT 2843
Query 2786 YKAIQDGVTRDIISTDDCFANKHAGFDAWF-SQRGGSYKNDKSCPVVAAIITREIGFIVP 2844
YK I++G+ RDI D CFANK+ F WF GG Y+N CP+ A+I G V
Sbjct 2844 YKVIENGIVRDIAPNDACFANKYGHFSKWFNENHGGVYRNSVDCPITIAVIAGVAGARVA 2903
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P T L + + F+ RVF+ N+C+TP+ I Y F+ S CVL++ECT+F+DA G
Sbjct 2904 NVPAT-LAWVGRQIVLFVSRVFANT-NVCFTPTNEIPYDTFSDSGCVLSSECTLFRDAEG 2961
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P+CYD +L G+ SY++++P RY + D I+FP E ++R+ T +YCR
Sbjct 2962 NLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIFESTLRITKTLATQYCRF 3021
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G+CE S G+C+ST+G W L N++Y G++CG D +++ + L QPV +S S
Sbjct 3022 GSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAVSLFQPVTYFQLSTS 3081
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
+ G ++ + +T A YY K +R +Y + L++ LC + A L Y+
Sbjct 3082 LAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCLCFIVANPLLVAPYT 3141
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV- 3142
Y Y TFY T + +F+ H+ W+ MF +VP W+ A Y + L+H W + +K V
Sbjct 3142 AMYYYATFYLTGEPAFIMHISWYVMFGTVVPIWMLASYTVGVMLRHLFWVLAYFSKKHVD 3201
Query 3143 -MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTT 3201
+G +F++AA F++ K+ Y+ LR+ + + RYL+L+NKYKY+SGA+DT
Sbjct 3202 VFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRYLSLFNKYKYYSGAMDTA 3259
Query 3202 SYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
SYREA HL KAL +S +G+D+LYQPP S+TS+VLQSG KM+ PSG VE C+VQVT
Sbjct 3260 SYREACAAHLCKALQTYSETGSDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVT 3319
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVI 3318
CG+ TLNGLWLD+TV+CPRH++C A+ + +PNY+ LLI K+NHSF+VQ LRV+
Sbjct 3320 CGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKTNHSFIVQKHIGAQANLRVV 3379
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
HSM LL+L VD +NP TP Y F ++PG +FSVLACYNG P+GV+ +R N TIKG
Sbjct 3380 AHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKG 3439
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ + ++F YMH MEL G H G+ +G YG F D+QT Q TD
Sbjct 3440 SFLCGSCGSVGYTENGGVLNFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDK 3499
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
T+NV+AWLYAAV+NG +WF+ + +N A+ + + L+ +TG
Sbjct 3500 YCTINVVAWLYAAVLNGCKWFVKPTRVGIVTYNEWALSNQFTEFVG--TQSIDMLAHRTG 3557
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
++V M AA++ L G G+TILG + LEDEFTP DV Q GV Q K+I G H
Sbjct 3558 VSVEQMLAAIQSL-HAGFQGKTILGQSTLEDEFTPDDVNMQVMGVVMQSGVKRISYGFMH 3616
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ T + + + ++Q T+++++ +++E T + AC M VKHKH FL LFLL
Sbjct 3617 WLMSTLVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLFGFMACVMFTVKHKHTFLSLFLL 3676
Query 3619 PSLATVAYFNMVYMPASWV----MRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTA 3674
P + Y N+VY P + V + + WL + L D +Y S +L ++
Sbjct 3677 PVALCLTYANIVYEPQTLVSSTLIAVANWLTPTSVYMRTTHL-DFGLYISLSFVLAIIVR 3735
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R + L + + Y G+ I+ + ++TS+Y+ V + LA+
Sbjct 3736 RLYRPSMSNLALALCSGVMWFYTYVIGDH-SSPITYLMFITTLTSDYTITVFATVNLAKF 3794
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
I + Y P L ++ ++L+Y LGY C YFG+F LLN R+ LGVYDY VST
Sbjct 3795 ISGLVFLYAPHLGFILPEVKLVLLIYLCLGYMCTMYFGVFSLLNLKLRVPLGVYDYSVST 3854
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
QEFR++ GL P++S +A LN KLLGIGG PCIKVATVQSK++D+KCTSVVLL+VLQ
Sbjct 3855 QEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQ 3914
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
QL +ES+SK W+ CV+LHN+IL A D TEAFE+ V L + L+S VD++ L ++ +N
Sbjct 3915 QLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFEN 3974
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAA 3973
+ LQA +EFS L +YA TAQ +Y++A+ +GD S VLK L+K++NVAK+ +++D A
Sbjct 3975 SSVLQATLTEFSHLATYAELETAQSSYQKALNSGDASPQVLKALQKAVNVAKNAYEKDKA 4034
Query 3974 MQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGC 4033
+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN +I NAR+GC
Sbjct 4035 VARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGC 4094
Query 4034 VPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINM 4093
VPL+I+PL + KL VV+PD + + + +YA +LW++ + + D+++V+ +++
Sbjct 4095 VPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDVTVINNVDNEVVKPTDVVE 4154
Query 4094 DNSPNLAWPLIVTALRA-NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNS 4152
N +L WPL++ RA +SAVKLQNNE+ P L+ M AG Q C+ +A+AYY
Sbjct 4155 TN-ESLTWPLVIECSRASSSAVKLQNNEIHPKGLKTMVVTAGIDQVNCS-SSAVAYYEPV 4212
Query 4153 KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLN 4212
+G R V+ LLS++ LKWA+ DG I EL+PPC+F+ PKGP+++YLYF+K LN
Sbjct 4213 QGHRMVMGLLSENAHLKWAKVEGKDGF--INIELQPPCKFLIAGPKGPEIRYLYFVKNLN 4270
Query 4213 NLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCV 4272
NL+RG +LG +AATVRLQAG TE +NSTVL+ AFAVDPAKAY DY+ SGG P++N V
Sbjct 4271 NLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYV 4330
Query 4273 KMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTT 4332
KML TGTG AI+V PEA DQE++GGAS CLYCR HI+HP+ G C K ++VQIP
Sbjct 4331 KMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAH 4390
Query 4333 CANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
DPVGF L+N C VC W GYGC+CD LR + + + FLN
Sbjct 4391 -VRDPVGFLLKNVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLN 4435
>sp|P0C6F7|R1A_BC133 Replicase polyprotein 1a OS=Bat coronavirus
133/2005 OX=389230 GN=1a PE=3 SV=1
Length=4441
Score = 4435 bits (11502), Expect = 0.0, Method: Composition-based stats.
Identities = 1470/4550 (32%), Positives = 2268/4550 (50%), Gaps = 306/4550 (7%)
Query 8 VNEKT--HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLK-NGTCGLVELE-KGV 60
NEK HV ++P+ D+ L F D E A ++ LK G V + +
Sbjct 21 YNEKRSDHVACTVPLCDTEDMASKLTPWFEDG-ETAFNQVSSILKEKGKILFVPMHMQRA 79
Query 61 LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMD--GIQYGRSGI---TLGVLVPHVGETP 115
+ L P V++ H +V +A D G R+ + LG+ P+
Sbjct 80 MKFLPGPRVYLVERLTGGMLSKHFLVNQLAYKDHVGAAMMRTTLNVKPLGMFFPYDSSLE 139
Query 116 IAYRNVLLRKNGNKGAGGHSYGIDLKS---YDLGDELGTDPIEDYEQNWNTKHGSGALRE 172
LLRKNG G D K ++ D+L DP Y QN
Sbjct 140 TGEHTFLLRKNGLGGQLFRERPWDRKETPYVEILDDLEADPTGKYSQN------------ 187
Query 173 LTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAG--KSMCTLSEQLDYIESKRGVYC 230
L ++L GG VD CG +G P+ +A+ G + ++S R +
Sbjct 188 LLKKLIGGDCIP-VDQYMCGKNGKPIADYAKIVAKEGLTTLADIEVDVKSRMDSDRFI-V 245
Query 231 CRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQP-RVE 289
+ + W R + Y QT F + S + D K P+ F + S++ ++ P +
Sbjct 246 LNKKLYRVVWNVTRRNVPYSKQTAFTVVSVIQCDD-KESVPEHTFTIGSQILMVSPLKAT 304
Query 290 KKKTEGFMGRI-RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTEN 348
K R+ + Y + Q+ ++ S + CN C +W T + ++ CG
Sbjct 305 NNKNFNLKQRLLHTFYGKEAVQQPGYIYHSAYVDCNACGRGTWCTGNAIQGFACDCGANY 364
Query 349 LVIE-GPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGR--TRC 405
+ + G +P NA+ CP + H+ A ++ + + + GG+ T
Sbjct 365 SANDVDLQSSGLVPKNALFLANCPCANNGAC--SHNAAQVYSILDGKACVEVGGKSFTLT 422
Query 406 FGGCVFAYVGCYNKRAYWVPRASA-------DIGSGHTGITGDNVETLNEDLLEILSRER 458
FGG V+AY+GC + Y+VPRA + I +G TG VET N L + +
Sbjct 423 FGGVVYAYMGCCDGTMYFVPRAKSCVSRIGDAIFTGCTGTWDKVVETAN----LFLEKAQ 478
Query 459 VNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGN--YKVTKGKP 516
++N F L E ++LA S +TS F + S++ + + N + VT G
Sbjct 479 HSLNFCQQFALTE---VVLAILSGTTSTFEELRDLCHNASYEKVRDHLVNHGFVVTIGDY 535
Query 517 VKGAWNIGQQ----RSVLTPLCGFPS------QAAGVIRSIFARTLDAANHSIPDLQRAA 566
++ A NIG ++ P F + A + I + A ++ ++
Sbjct 536 IRDAINIGANGVCNATINAPFIAFTGLGESFKKVAAIPWKICSNLKSALDYYCSNIMFRV 595
Query 567 V--TILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKL 624
I +++ L+D T V +V L ++ L + L
Sbjct 596 FPYDIPCDVNDFVELLLDCGKLT-------VATSYFVLRYLDEKFDTVLGTVSNACQTAL 648
Query 625 RPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNK 684
A A F+ D +++ K L+ ++ +++ V+ +D+++K
Sbjct 649 SSFLNACVAASRATAGFISDMFKLFKVLMHKLYVYTSCGYVAVAEHSSKIVQQVLDIMSK 708
Query 685 ALEMCIDQVTIAGAKLRSLNL--GEVFIAQSKGLYRQCIRGK---EQLQLLMPLKAPKEV 739
A+++ V+ AG KL ++ E + S + + K +Q+ L++P K+
Sbjct 709 AMKLLHTNVSWAGTKLSAIIYEGREALLFNSGTYFCLSTKAKTLQDQMNLVLPGDYNKKT 768
Query 740 TFL-----EGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIK 794
+ D+ D S V + +G+LE P + IVG V V+ + +
Sbjct 769 LGILDPVPNADTIDVTANSTVVDVVHGQLE----PTNEHGPSMIVGNYVLVSDKLFVRTD 824
Query 795 DKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL 854
D+E Y G + + +FRLKGG P K VTFG+ EV Y++V IT+++ +D +L
Sbjct 825 DEEFYPLCINGKVVS-TLFRLKGGMPSKKVTFGDVNTVEVTAYRSVSITYDIHPVLDALL 883
Query 855 NE-KCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAG 913
+ K + +TVE V +F V+ + V+ L P+ G D++++ Y+++ G
Sbjct 884 SSSKLATFTVEKDLLVEDFVDVIKDEVLTLLTPLLRGYDIDGFDVEDFIDVPCYVYNQDG 943
Query 914 EENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRV 973
+ +SS M S P ++ EE + E++ + + E DD + + + E V
Sbjct 944 DCAWSSNMTFSINPVEDVEEVEEFIEDDYLSD----ELPIADDEEA----WTRAVEEVMP 995
Query 974 EEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPM 1033
++ ++ E +E E E + L + + + + + +
Sbjct 996 LDDILVAEIELE-EDLPLETALESVEAEVGESISDELCVVETAKAQEPSVESTDSTPSTS 1054
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLT-VGGSCLLSGHNLAKKC 1092
+V+ ++ +K VA T ++ E+ GP++ V S +
Sbjct 1055 TVVSENDLSVKPMSRVAE-----TGDVLEVETAVV---GGPVSDVTASVVT--------- 1097
Query 1093 LHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVY 1152
DI ++ A + G+ + QV
Sbjct 1098 -----------NDIVSVEQAQQ--------------CGVSSLPIQ---DEASENQVHQVP 1129
Query 1153 IAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACI 1212
++V D R+ K + + SV D
Sbjct 1130 DLQCTSETKVEIVQPRQDLRPRRLR--KSKVDLSKYKHTVINNSVTLVLGDAIQIASLLP 1187
Query 1213 DEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS--- 1269
V I G + S ++ E ++ P VGD +
Sbjct 1188 KCVLVNAANRHLKHG-----GGIAGAINKASGGDVQEESDEYISNSGPLHVGDSVLLKGY 1242
Query 1270 ---GDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCK 1326
I VV P + +L R K +++ +G + K + +
Sbjct 1243 GLADAILRVVGPDARNNEDAALLKRCYKTF--NKHTIVVTPLISSGIFSVDPKVSFEYLL 1300
Query 1327 SAF-----------YVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIM 1375
+ + + A +K + L R + A+ IC + A +
Sbjct 1301 ANVTTTTYVVVNNEDIYNTLATPSKPDGLVYSFEGWRGTVRTAKNYGFTCFICTEYSANV 1360
Query 1376 ATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNL 1435
++ K + VD GV ++ Y++++ + +I N + MP GYVTHG +L
Sbjct 1361 KFLRTKGVDTTKKIQTVD-GVSYYLYSARDALTDVIAAANGCP-GICAMPFGYVTHGLDL 1418
Query 1436 EEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSY-SG 1494
++ +R +K P V ++S + + N + + +T E F+ V+ G Y W SG
Sbjct 1419 AQSGNYVRQVKVPYVCLLASKEQIPIMNSDV--AIQTPETAFINNVTSNGGYHSWHLVSG 1476
Query 1495 QRTELGVEFLK----RGDKIVY-----HTLESPVEFHLDGEVLSLDKLKSLLSLREVK-- 1543
V + K G I Y + +++ V L+ ++ L+ R +
Sbjct 1477 DLIVKDVCYKKLLHWSGQTICYADNKFYVVKNDVALPFS----DLEACRAYLTSRAAQQV 1532
Query 1544 TIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDT 1603
I+V T+D N T +++ + T+ +Q G T+ G D++ P V G++ FV +
Sbjct 1533 NIEVLVTIDGVNFRTVILNDATTFRKQLGATFYKGVDISDALPTVKMGGESLFVADNLSE 1592
Query 1604 LRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
EYY T D +FL RY S ++WKF G+ S+K ++ NCY+++ ++ +
Sbjct 1593 SEEVVLKEYYGTSDVTFLQRYYSLQPLVQQWKFVVHDGVKSLKLSNYNCYINATIMMIDM 1652
Query 1663 L-EVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-S 1720
L ++KF PALQ AY R + GD +F ALI+AY + T D + + LL A L S
Sbjct 1653 LHDIKFVVPALQNAYLRYKGGDPYDFLALIMAYGDCTFDNPDDEAKLLHTLLAKAELTVS 1712
Query 1721 AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
AK V C CG + TG+ A +Y G S + L++ + CVCG + LV+ +
Sbjct 1713 AKMVWREWCTVCGIRDIEYTGMRACVYAGVNSMEELQSVFNETCVCGSVKHRQLVEHSTP 1772
Query 1781 FVMMSAPPAEYKLQQG--TFLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEY 1836
++++S + N + G GHY H+ K+ L Y+ D LTK S+
Sbjct 1773 WLLVSGLNEVKVSTSTDPVYRAFNVFQGVETSVGHYVHVRVKDGLFYKYDSGSLTKTSDM 1832
Query 1837 KGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQP-IDLVPTQ 1895
K +T V+Y + YT V Y LDGVT E+ P L YY KD YYT +P I P
Sbjct 1833 KCKMTSVWYPKVRYTADCNVVVYDLDGVTKVEVNPDLSNYYMKDGKYYTSKPTIKYSPAT 1892
Query 1896 PLPNASFDNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAID 1948
LP + + N L + D N + GF TKP S++L+ + P+ +GDV+ +
Sbjct 1893 ILPGSVYSNSCLVGVDGTPGSDTISKFFNDLLGFDETKPISKKLTYSLLPNEDGDVLLSE 1952
Query 1949 YRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVE 2008
+ +Y+ +KKG L KPI+W N KPN LR L+ P+ N + VL
Sbjct 1953 FNNYNPVYKKGVMLKGKPILWVNNGVCDSALNKPNRASLRQLYDVAPIVLDNKYTVLQDN 2012
Query 2009 DTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVK---TTEVVGNVILKPSDEGVKVTQ 2065
+Q E P E+V +++IE K V GN GV V
Sbjct 2013 TSQ-----LIEPNVPVVEDVS---ITTRKLIEVKCKGLNKPFVKGNFSFVNDPNGVTVVD 2064
Query 2066 ELGHEDLMAAYVE-NTSITIKKPNELSLALGLKTIATHGIAAI---NSVPWS-KILAYVK 2120
LG +L A YV+ NT + + N S L T+ + + + SV ++L
Sbjct 2065 TLGLTELRALYVDINTRYIVLRDNNWSSLFKLHTVESGDLQIVANGGSVTRRARVLLGAS 2124
Query 2121 PFLGQAAITTSNCAKRLAQRVFNNYMPYVFTL----------------LFQLCTFTKSTN 2164
A T + ++ +V F K
Sbjct 2125 SLFASFAKITVTATTAACKTAGRSFCKFVVNYGVLQNMFLFLKMLFFLPFNYLWPKKQPT 2184
Query 2165 SRIRASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTI-------------AM 2208
+ S T + N VK + K + +
Sbjct 2185 VDVGVSGLRTAGVVTTNIVKQCGTAAYYMLLGKFKRVDWKATLRLFLLLCTTILLLSSIY 2244
Query 2209 WLLLLSICLGSLICVTAAFGVLL------SNFGAPSYCNGVRELYLNSSNVTTMDFCEG- 2261
L++ + L S + + A G+L S G + C+G+ Y N+S +DFC
Sbjct 2245 HLVIFNQVLSSDVMLEDATGILAMYKEVRSYLGIRTLCDGLAVEYRNTS-FDVVDFCSNR 2303
Query 2262 SFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLS 2321
S C CL G DSL Y AL+ +Q I+SY L++ + A E+ LAY+L+T F +L L
Sbjct 2304 SVLCQWCLIGQDSLTRYSALQMLQTHITSYVLNIDWIWFALEFFLAYVLYTSSFNVLLLV 2363
Query 2322 AIMQVFFGYFASH--FISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
Q FF Y ++ + + ++++ + +V P+ +VR+Y F A +++ K Y H+++
Sbjct 2364 VTAQYFFAYTSAFVNWRAYNYIVSGLFFLVTHIPLHGLVRVYNFLACLWFLRKFYSHVIN 2423
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC + C++CYKRNR TRVE +TIV G KR+FY+ ANGG +C HNWNC+ CDT G+
Sbjct 2424 GCKDTACLLCYKRNRLTRVEASTIVCGTKRTFYIAANGGTSYCCKHNWNCVECDTAGVGN 2483
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI EVA DL+ +R I PTDQS Y VDSV VK+ + L++++ G YER+PL +F
Sbjct 2484 TFICTEVANDLTTTLRRLIKPTDQSHYYVDSVVVKDAVVELHYNRDGSSCYERYPLCYFT 2543
Query 2500 NLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
NL+ L+ G N +++D + E+ ++SA VYYSQ++C+P+LL+D LV+
Sbjct 2544 NLEKLKFKEVCKTPTGIPEHNFLIYDTNDRGQENLARSACVYYSQVLCKPMLLVDVNLVT 2603
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VGDS E+++KM D+++++F + FSV +KL+ L+ TA + +G VL TF AAR
Sbjct 2604 TVGDSREIAIKMLDSFINSFISLFSVSRDKLEKLINTARDCVRRGDDFQTVLKTFTDAAR 2663
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
V++DV+T V++ L+ +H +D+++T + NN++ Y K +++ DLG ID A
Sbjct 2664 GHAGVESDVETTMVVDALQYAHKNDIQLTTECYNNYVPGYIKPDSINTLDLGCLIDLKAA 2723
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
+N ++ N + +WN DYM LS+ ++QIR A +K NIPFRLT + R N+++ K
Sbjct 2724 SVNQTSMRNANGACVWNSGDYMKLSDSFKRQIRIACRKCNIPFRLTTSKLRAADNILSVK 2783
Query 2735 ISLKG--GKIVSTCF-------KLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIG 2785
S G S K TL A++ + +P ++++ + + I+
Sbjct 2784 FSATKIVGGAPSWLLRVRDLTVKGYCILTLFVFTVAVLSWFCLPSYSIATVNFNDDRILT 2843
Query 2786 YKAIQDGVTRDIISTDDCFANKHAGFDAWF-SQRGGSYKNDKSCPVVAAIITREIGFIVP 2844
YK I++G+ RDI D CFANK+ F WF GG Y+N CP+ A+I G V
Sbjct 2844 YKVIENGIVRDIAPNDACFANKYGHFSKWFNENHGGVYRNSVDCPITIAVIAGVAGARVA 2903
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P T L + + F+ RVF+ N+C+TP+ I Y F+ S CVL++ECT+F+DA G
Sbjct 2904 NVPAT-LAWVGRQIVLFVSRVFANT-NVCFTPTNEIPYDTFSDSGCVLSSECTLFRDAEG 2961
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P+CYD +L G+ SY++++P RY + D I+FP E ++R+ T +YCR
Sbjct 2962 NLNPFCYDPTVLPGASSYADMKPHVRYDMYDSDMYIKFPEVIFESTLRITKTLATQYCRF 3021
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G+CE S G+C+ST+G W L N++Y G++CG D +++ + L QPV +S S
Sbjct 3022 GSCEESAAGVCISTNGSWALYNQNYSTRPGIYCGDDYFDIVRRLAVSLFQPVTYFQLSTS 3081
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
+ G ++ + +T A YY K +R +Y + L++ LC + A L Y+
Sbjct 3082 LAMGLVLCVFLTAAFYYINKVKRALADYTQCAVVAVVAALLNSLCLCFIVANPLLVAPYT 3141
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV- 3142
Y Y TFY T + +F+ H+ W+ MF +VP W+ A Y + L+H W + +K V
Sbjct 3142 AMYYYATFYLTGEPAFIMHISWYVMFGTVVPIWMLASYTVGVMLRHLFWVLAYFSKKHVD 3201
Query 3143 -MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTT 3201
+G +F++AA F++ K+ Y+ LR+ + + RYL+L+NKYKY+SGA+DT
Sbjct 3202 VFTDGKLNCSFQDAASNIFVIGKDTYVALRNA--ITQDSFVRYLSLFNKYKYYSGAMDTA 3259
Query 3202 SYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVT 3261
SYREA HL KAL +S +G+D+LYQPP S+TS+VLQSG KM+ PSG VE C+VQVT
Sbjct 3260 SYREACAAHLCKALQTYSETGSDILYQPPNCSVTSSVLQSGLVKMSAPSGAVENCIVQVT 3319
Query 3262 CGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRVI 3318
CG+ TLNGLWLD+TV+CPRH++C A+ + +PNY+ LLI K+NHSF+VQ LRV+
Sbjct 3320 CGSMTLNGLWLDNTVWCPRHIMCPADQLTDPNYDALLISKTNHSFIVQKHIGAQANLRVV 3379
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
HSM LL+L VD +NP TP Y F ++PG +FSVLACYNG P+GV+ +R N TIKG
Sbjct 3380 AHSMVGVLLKLTVDVANPSTPAYTFSTVKPGASFSVLACYNGKPTGVFTVNLRHNSTIKG 3439
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ + ++F YMH MEL G H G+ +G YG F D+QT Q TD
Sbjct 3440 SFLCGSCGSVGYTENGGVLNFVYMHQMELSNGTHTGSSFDGVMYGAFEDKQTHQLQLTDK 3499
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
T+NV+AWLYAAV+NG +WF+ + +N A+ + + L+ +TG
Sbjct 3500 YCTINVVAWLYAAVLNGCKWFVKPTRVGIVTYNEWALSNQFTEFVG--TQSIDMLAHRTG 3557
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
++V M AA++ L G G+TILG + LEDEFTP DV Q GV Q K+I G H
Sbjct 3558 VSVEQMLAAIQSL-HAGFQGKTILGQSTLEDEFTPDDVNMQVMGVVMQSGVKRISYGFMH 3616
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ T + + + ++Q T+++++ +++E T + AC M VKHKH FL LFLL
Sbjct 3617 WLMSTLVLAYVSVMQLTKFTMWTYLFETIPTQMTPLLFGFMACVMFTVKHKHTFLSLFLL 3676
Query 3619 PSLATVAYFNMVYMPASWV----MRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTA 3674
P + Y N+VY P + V + + WL + L D +Y S +L ++
Sbjct 3677 PVALCLTYANIVYEPQTLVSSTLIAVANWLTPTSVYMRTTHL-DFGLYISLSFVLAIIVR 3735
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
R + L + + Y G+ I+ + ++TS+Y+ V + LA+
Sbjct 3736 RLYRPSMSNLALALCSGVMWFYTYVIGDH-SSPITYLMFITTLTSDYTITVFATVNLAKF 3794
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
I + Y P L ++ ++L+Y LGY C YFG+F LLN R+ LGVYDY VST
Sbjct 3795 ISGLVFLYAPHLGFILPEVKLVLLIYLCLGYMCTMYFGVFSLLNLKLRVPLGVYDYSVST 3854
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
QEFR++ GL P++S +A LN KLLGIGG PCIKVATVQSK++D+KCTSVVLL+VLQ
Sbjct 3855 QEFRFLTGNGLHAPRNSWEALILNFKLLGIGGTPCIKVATVQSKLTDLKCTSVVLLTVLQ 3914
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
QL +ES+SK W+ CV+LHN+IL A D TEAFE+ V L + L+S VD++ L ++ +N
Sbjct 3915 QLHLESNSKAWSYCVKLHNEILAAVDPTEAFERFVCLFATLMSFSANVDLDALANDLFEN 3974
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDAA 3973
+ LQA +EFS L +YA TAQ +Y++A+ +GD S VLK L+K++NVAK+ +++D A
Sbjct 3975 SSVLQATLTEFSHLATYAELETAQSSYQKALNSGDASPQVLKALQKAVNVAKNAYEKDKA 4034
Query 3974 MQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGC 4033
+ RKLE+MA+QAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN +I NAR+GC
Sbjct 4035 VARKLERMAEQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGVIANARNGC 4094
Query 4034 VPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINM 4093
VPL+I+PL + KL VV+PD + + + +YA +LW++ + + D+++V+ +++
Sbjct 4095 VPLSIVPLCASNKLRVVIPDISVWNKVVNWPSVSYAGSLWDVTVINNVDNEVVKPTDVVE 4154
Query 4094 DNSPNLAWPLIVTALRA-NSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNS 4152
N +L WPL++ RA +SAVKLQNNE+ P L+ M AG Q C+ +A+AYY
Sbjct 4155 TN-ESLTWPLVIECSRASSSAVKLQNNEIHPKGLKTMVVTAGIDQVNCS-SSAVAYYEPV 4212
Query 4153 KGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLN 4212
+G R V+ LLS++ LKWA+ DG I EL+PPC+F+ PKGP+++YLYF+K LN
Sbjct 4213 QGHRMVMGLLSENAHLKWAKVEGKDGF--INIELQPPCKFLIAGPKGPEIRYLYFVKNLN 4270
Query 4213 NLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCV 4272
NL+RG +LG +AATVRLQAG TE +NSTVL+ AFAVDPAKAY DY+ SGG P++N V
Sbjct 4271 NLHRGQLLGHIAATVRLQAGANTEFASNSTVLTLVAFAVDPAKAYLDYVGSGGTPLSNYV 4330
Query 4273 KMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTT 4332
KML TGTG AI+V PEA DQE++GGAS CLYCR HI+HP+ G C K ++VQIP
Sbjct 4331 KMLAPKTGTGVAISVKPEATADQETYGGASVCLYCRAHIEHPDVSGVCKYKTRFVQIPAH 4390
Query 4333 CANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
DPVGF L+N C VC W GYGC+CD LR + + + FLN V
Sbjct 4391 -VRDPVGFLLKNVPCNVCQYWVGYGCNCDALRNNTVPQSKDTNFLNESGV 4439
>sp|P0C6T6|R1A_BCHK9 Replicase polyprotein 1a OS=Bat coronavirus
HKU9 OX=694006 GN=1a PE=3 SV=1
Length=4248
Score = 4365 bits (11322), Expect = 0.0, Method: Composition-based stats.
Identities = 1586/4459 (36%), Positives = 2369/4459 (53%), Gaps = 346/4459 (8%)
Query 28 VRGFGDSVEEALSEAREHLKNGTCGLVELEKGV--LPQLEQPYVFIKRSDALSTNHG-HK 84
V G+ +EEAL A++ L+ LV + + P + V I S +TN G
Sbjct 29 VTGWDIPIEEALEYAKQQLRTPEPQLVFVPYYLSHAPGISGDRVVITDSIWYATNFGWQP 88
Query 85 VVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYR-NVLLRKNGNKGAGGHSYGIDLKSY 143
+ EL + DG++YGR G T GVL+P + I ++ +RK G G +S L +
Sbjct 89 IRELAMDKDGVRYGRGG-THGVLLPMQDPSFIMGDIDIQIRK---YGIGANSPPDVLPLW 144
Query 144 DLGDELGTD--PIEDYEQNW---NTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPL 198
D + G D P D+ N K G L+ + DNN G +
Sbjct 145 DGFSDPGPDVGPYLDFPDNCCPTKPKAKRGGDVYLSDQYG-------FDNN-----GILV 192
Query 199 DCIKDFLARAGKSMCTLSEQLDYIESKR--GVYCCRDHEHEIAWFTERSDKSYEHQTPFE 256
+ + L KS TL + L + R Y D ++A R Q+ F
Sbjct 193 EPVMKLLGVI-KSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFT 251
Query 257 IKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGR-IRSVYPVASPQECNNM 315
+ + P + +P ++ V K G +G+ + +V + S NN
Sbjct 252 VVGVT-----EQLVPGYYYPFSTSSVVEH---TKPTRGGPVGKTVEAV--MLSLYGTNNY 301
Query 316 HLST---LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPA 372
+ +T +KC++CD W + CG E + ++C + V+K C
Sbjct 302 NPATPVARLKCSYCDYYGWTPLKDIGTVNCLCGAE---FQLTSSCVDAESAGVIKPGCVM 358
Query 373 CQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC-FGGCVFAYVGCYNKRAYWVPRASADI 431
D G RL G RT FGG +++ +G N WVPRA + +
Sbjct 359 LLDKSPG---------------MRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIV 403
Query 432 GSGHTGITGD-NVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA-FID 489
H+G G + +N++L+E L I + D N A +A+ T A +
Sbjct 404 AGEHSGAVGSGDTVAINKELVEYLIE---GIRVDADTLDNPTCATFIANLDCDTKAPVVH 460
Query 490 TIKSLDYKSFKTIVESCGNYKVTKG-KPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIF 548
T++SL C K+ G KP+ + + L + Q A ++
Sbjct 461 TVESLQ--------GLCLANKIMLGDKPLP----TDEFHPFIVGL-AYHVQRACWYGALA 507
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-VTGGLVQ 607
+RT +A D R + ++ VY + + AY V +
Sbjct 508 SRTFEAFR----DFVRTEEERFAQFFGKVCAPINGCVYLAYTTGRVTLFSAYQVLNTAIA 563
Query 608 QTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVA 667
++ + V+ L+PI EW+ K+S E L L F +VKG+ Q
Sbjct 564 KSKDAFGGVAAIVVDMLKPILEWVLKKMSIAKGAWLPYAEGLLALFKAQFTVVKGKFQFL 623
Query 668 SDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQL 727
++ D++ + + V AG K+ +L G + KG+ + ++L
Sbjct 624 RASLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALYTGTYYYFSRKGVLTEVQLCAKRL 683
Query 728 QLLM-PLKAPKEVTFLEGDSH-DTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCV 785
LL+ P + EV L+GD LT E+ G LE + D + GT V +
Sbjct 684 GLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGVLEEVFGASDV---KLVKGTLVSL 740
Query 786 NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFE 845
+ + +D Y + G + FRL+GG + VTFG++ V + V +++
Sbjct 741 ASKLFVRTEDGFLYRYVKSGGV-LGKAFRLRGGG-VSKVTFGDEEVHTIPNTVTVNFSYD 798
Query 846 LDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTN-----MGIDLDE 900
+ E +D +L++ + + VE GT++ + ACVV +AV + L DL ++ I+L++
Sbjct 799 VCEGLDAILDKVMAPFQVEEGTKLEDLACVVQKAVYERLS---DLFSDCPAELRPINLED 855
Query 901 WSVATFYLFDDAGEENFSSRMYCSF---YPPDEEEEDDAECEEEEIDETCEHEYGTEDDY 957
+ + +++ E+ MY S P D+E DD I++T E ++D +
Sbjct 856 FLTSECFVYSKDYEKILMPEMYFSLEDAVPVDDEMVDD-------IEDTVEQASDSDDQW 908
Query 958 QGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVA 1017
G +E + D+T + ++ GY K+ ++V
Sbjct 909 LG----------------DEGAEDCDNTIQDVDVATSMTTPC--------GYTKIAEHVY 944
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
IKC DIV+EA++ + V+VNAAN++L HGGGVAGALN+ATN AMQKES +YIK NG L
Sbjct 945 IKCADIVQEARNYSYAVLVNAANVNLHHGGGVAGALNRATNNAMQKESSEYIKANGSLQP 1004
Query 1078 GGSCLLSGHNLAKK-CLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKP 1136
GG LLS H LA LHVVGP+ G+D+ LL A Y + D +L PL+SAGIFG
Sbjct 1005 GGHVLLSSHGLASHGILHVVGPDKRLGQDLALLDAVYAAYTGFDSVLTPLVSAGIFGFTV 1064
Query 1137 LQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKS 1196
+SL V+ V Y+ V D+ LYE+ + D P+ E + +E
Sbjct 1065 EESLCSLVKNVACTTYVVVYDRQLYERALATSFDVPGPQSSVQHVPAIDWAEAVEVQESI 1124
Query 1197 VVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL--LFADINGKLYHDSQNMLRGEDMSF 1254
V Q V+ +D V + + T + + + + D ++ +R
Sbjct 1125 VDQ----VETPSLGAVDTVDSNADSGLNETARSPENVVGSVPDDVVADVESCVRD----- 1175
Query 1255 LEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYT 1314
++ + +KKV D+ Q T
Sbjct 1176 ---------------------------------LVRQVVKKVKRDKRPPPIVPQ----QT 1198
Query 1315 LEEAKTALKKCKSAFYVLPSEAPNA---KEEILGTVSWNLREMLAHAEETRKLMPICMDV 1371
+E+ P E + ++ VS + M+ +E L+P+ +D
Sbjct 1199 VEQQ--------------PQEISSPGDCNTVLVDVVSMSFSAMVNFGKEKGLLIPVVIDY 1244
Query 1372 RAIMATIQRKYKGIKIQEGIVDY-GVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVT 1430
A + ++R +EG+ G F+ Y+ +P+ + LNSL PL+ +P G++
Sbjct 1245 PAFLKVLKR----FSPKEGLFSSNGYEFYGYSRDKPLHEVSKDLNSLGRPLIMIPFGFIV 1300
Query 1431 HGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLT---SSSKTSEEHFVETVSLAGSY 1487
+G L +A MR L P V V S +V Y Y S T+ + FV + L G+
Sbjct 1301 NGQTLAVSAVSMRGLTVPHTVVVPSESSVPLYRAYFNGVFSGDTTAVQDFVVDILLNGA- 1359
Query 1488 RDWSYSGQRTELGVE------FLKRGDKIVYHTLESPVEFHLDGEVL----SLDKLKSLL 1537
RDW +T V+ KRG+ Y + + + G+V+ ++ K ++ L
Sbjct 1360 RDWDV--LQTTCTVDRKVYKTICKRGN--TYLCFDDTNLYAITGDVVLKFATVSKARAYL 1415
Query 1538 SLR---EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKT 1594
+ IKV TTVD N T LV + +Y Q G + DG D + P EG
Sbjct 1416 ETKLCAPEPLIKVLTTVDGINYSTVLVSTAQSYRAQIGTVFCDGHDWSNKNPMPTDEGTH 1475
Query 1595 FFVLPSDDTLRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYL 1653
+ + + A EYY D + + R MS + W + V G + D+NCYL
Sbjct 1476 LYKQDNFSSAEVTAIREYYGVDDSNIIARAMSIRKTVQTWPYTVVDGRVLLAQRDSNCYL 1535
Query 1654 SSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLL 1713
+ + LQ ++V F+ P + AY + G+ +++A T G D ++ +L
Sbjct 1536 NVAISLLQDIDVSFSTPWVCRAYDALKGGNPLPMAEVLIALGKATPGVSDDAHMVLSAVL 1595
Query 1714 QHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQY 1773
H + +A+RV+ VC+HCG TG +A + G++ D+L VS+ C CGR A +Y
Sbjct 1596 NHGTV-TARRVMQTVCEHCGVSQMVFTGTDACTFYGSVVLDDLYAPVSVVCQCGRPAIRY 1654
Query 1774 LVQQESSFVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTK 1832
+ +Q+S +++MS P + L G + A + G GHY + + D +
Sbjct 1655 VSEQKSPWLLMSCTPTQVPLDTSGIWKTAIVFRGPVTAGHYMYAVNGTLISVYDANTRRR 1714
Query 1833 MSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLV 1892
S+ K P TD+ Y TS+T+ K +Y LDGV T I+P Y K+ + Y+T PI++V
Sbjct 1715 TSDLKLPATDILYGPTSFTSDSKVETYYLDGVKRTTIDPDFSKYVKRGDYYFTTAPIEVV 1774
Query 1893 PTQPLPNASFDNFKLT-CSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRH 1951
P S+D F L+ C N + A+ N+ TK +L +T +P++ GDVVAI +
Sbjct 1775 -AAPKLVTSYDGFYLSSCQNPQLAESFNKAINATKTGPMKL-LTMYPNVAGDVVAISDDN 1832
Query 1952 YSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWC-LRCLWSTKPVDTSNSFEVLAVEDT 2010
A G+ + KP+++ +PNTW L L ST V+T N+++VLAV+
Sbjct 1833 VVAH-PYGSLHMGKPVLFV---------TRPNTWKKLVPLLSTVVVNTPNTYDVLAVDPL 1882
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIEC-DVKTTEVVGNVILKPSDEG-VKVTQELG 2068
P + E E P K I +K T V+ P ++G + +E
Sbjct 1883 ------------PVNNETSEEPISVKAPIPLYGLKATMVLNGTTYVPGNKGHLLCLKEFT 1930
Query 2069 HEDLMAAYVENTS-ITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAA 2127
DL YVE + K + LS LGL+ + +N + + AY
Sbjct 1931 LTDLQTFYVEGVQPFVLLKASHLSKVLGLRV--SDSSLHVNHLSKGVVYAYA-------- 1980
Query 2128 ITTSNCAKRLAQRVFNNYMPYVFTL-LFQLCTFTKSTNS------------RIRASLPTT 2174
A RL RV + + + T + + F +STN ++
Sbjct 1981 ------ATRLTTRVTTSLLGGLVTRSVRKTADFVRSTNPGSKCVGLLCLFYQLFMRFWLL 2034
Query 2175 IAKNSVKSVAKL-CLDAG-------INYVK-------SPKFSKLFTIAMWLLLLSICLGS 2219
+ K + V+ + + G +NY++ + KL +++ + CL
Sbjct 2035 VKKPPIVKVSGIIAYNTGCGVTTCVLNYLRSRCGNISWSRLLKLLRYMLYIWFVWTCLT- 2093
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRE--LYLNSSNVTTMDFCEGSFPCSICLSGLDSLDS 2277
GV LS APS + + + ++ + +C++G+DSLD
Sbjct 2094 ------ICGVWLSEPYAPSLVTRFKYFLGIVMPCDYVLVNETGTGWLHHLCMAGMDSLD- 2146
Query 2278 YPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFIS 2337
YPAL Q S + T + + E AY+L+T ++G+ A++ + Y +
Sbjct 2147 YPALRMQQHRYGS-PYNYTYILMLLEAFFAYLLYTPALPIVGILAVLHLIVLYLPIP-LG 2204
Query 2338 NSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATR 2397
NSWL+ F+ I+++ P ++M+RMYI A + +K ++H+ GC + C+MCYK+N A R
Sbjct 2205 NSWLVVFLYYIIRLVPFTSMLRMYIVIAFLWLCYKGFLHVRYGCNNVACLMCYKKNVAKR 2264
Query 2398 VECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRP 2457
+EC+T+VNG+KR FYV ANGG FC HNWNC++CDT+ STFI +VA DLS QFKRP
Sbjct 2265 IECSTVVNGVKRMFYVNANGGTHFCTKHNWNCVSCDTYTVDSTFICRQVALDLSAQFKRP 2324
Query 2458 INPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLP-IN 2516
I TD++ Y V SV V+NG ++ YF+ GQ++YER P+ F N+ L + KG+ P N
Sbjct 2325 IIHTDEAYYEVTSVEVRNGYVYCYFESDGQRSYERFPMDAFTNVSKLHYSELKGAAPAFN 2384
Query 2517 VIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFS 2576
V+VFD ++ +E+A K+A++YY+QL C+PILL+D+ +V VGD ++ MF+AY +
Sbjct 2385 VLVFDATNRIEENAVKTAAIYYAQLACKPILLVDKRMVGVVGDDATIARAMFEAYAQNYL 2444
Query 2577 ATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVD--TDVDTKDVIECLKL 2634
+S+ M+K+K L +TA +++ G+ ++ VL FV + R D +DVDT D++ C++L
Sbjct 2445 LKYSIAMDKVKHLYSTALQQISSGMTVESVLKVFVGSTRAEAKDLESDVDTNDLVSCIRL 2504
Query 2635 SHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKD 2694
H E T DS NN + TY K + ++ ++G + NA+++NA +AK V+LIW D
Sbjct 2505 CHQEGWEWTTDSWNNLVPTYIKQDTLSTLEVGQFMTANAKYVNANIAKGAAVNLIWRYAD 2564
Query 2695 YMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG--KIVSTCFKLMLK 2752
++ LSE +R+Q++ AA+K + +T ++ + V + T + GG +IVS L+
Sbjct 2565 FIKLSESMRRQLKVAARKTGLNLLVTTSSLKADVPCMVTPFKIIGGHRRIVSWRRVLIHV 2624
Query 2753 ATLLCVLA---ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
LL VL YI+ P+ ++ +K I + V RDI S D CFANK +
Sbjct 2625 FMLLVVLNPQWFTPWYIMRPIEY---------NVVDFKVIDNAVIRDITSADQCFANKFS 2675
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
F+ W+S R GSY N + CP+V +++ +G +VPGLP LR + L + AV
Sbjct 2676 AFENWYSNRYGSYVNSRGCPMVVGVVSDIVGSLVPGLPARFLR-VGTTLLPLVNYGLGAV 2734
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
G++CYTP I Y F TSACVLAA CT+F A G+ +PYC D L++ + Y L+P
Sbjct 2735 GSVCYTPHYAINYDVFDTSACVLAATCTLFSSASGERMPYCADAALIQNASRYDMLKPHV 2794
Query 2930 RYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHY 2988
Y + S I+FP V +V T EYC+ G C+ SE G+C+S RWV+NN ++
Sbjct 2795 MYPFYEHSGYIRFPEVIS-AGVHIVRTMAMEYCKVGRCDVSEAGLCMSLQPRWVVNNAYF 2853
Query 2989 RALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVF 3048
R SGV+CG A +L N+ P+ PVGA+D++ S++ G ++A++V+ + YY ++FRR F
Sbjct 2854 RQQSGVYCGTSAFDLFMNMLLPIFTPVGAVDITTSILMGALLAVVVSMSLYYLLRFRRAF 2913
Query 3049 GEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAM 3108
G+Y+ V+ N L F+++ +LCL Y LP +Y++ +LY T YF +D++ + H+ + M
Sbjct 2914 GDYSGVIFTNILAFVLNVIVLCLEGPYPMLPSIYAMVFLYATCYFGSDIACMMHVSFLIM 2973
Query 3109 FSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYL 3168
F+ +VP W+T +Y+ + +H WF + ++ V + F +F++AAL TF+L+KE++L
Sbjct 2974 FAGVVPLWVTVLYIVVVLSRHILWFASLCTKRTVQVGDLAFHSFQDAALQTFMLDKEVFL 3033
Query 3169 KLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQ 3228
+L+ E + Y +YLA+YNKYKY+SG +DT +YREAAC HL AL +SN G D +YQ
Sbjct 3034 RLKRE--ISSDAYFKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYSNGGGDTIYQ 3091
Query 3229 PPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAED 3288
PP+ S+ SA LQ+G +MA PSG VE C+V+V G+ TLNG+WLD+ V CPRHV+C+ ++
Sbjct 3092 PPRCSVASAALQAGLTRMAHPSGLVEPCLVKVNYGSMTLNGIWLDNFVICPRHVMCSRDE 3151
Query 3289 MLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQP 3348
+ NP+Y L +R +N+ F V +RVIGH+M+ LL+L VD +NPKTP Y F+R+
Sbjct 3152 LANPDYPRLSMRAANYDFHVSQNGHNIRVIGHTMEGSLLKLTVDVNNPKTPAYSFIRVST 3211
Query 3349 GQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELP 3408
GQ S+LACY+G P+GVY C +R N T++ SFL GSCGS GF ++ V FCY+H +ELP
Sbjct 3212 GQAMSLLACYDGLPTGVYTCTLRSNGTMRASFLCGSCGSPGFVMNGKEVQFCYLHQLELP 3271
Query 3409 TGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLN 3468
G H GTD G FYGPF D+Q Q A D TIT+NVLAWLYAAV++G+ WFL + + +
Sbjct 3272 NGTHTGTDFSGVFYGPFEDKQVPQLAAPDCTITVNVLAWLYAAVLSGENWFLTKSSISPA 3331
Query 3469 DFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILE 3528
+FN A+KY + +T + + +L PL+A+TGI+V M +ALK LL G GRTI+GS LE
Sbjct 3332 EFNNCAVKYMCQSVTSESLQVLQPLAAKTGISVERMLSALKVLLSAGFCGRTIMGSCSLE 3391
Query 3529 DEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAF 3588
DE TP+D+ RQ GV QGKF+ + + T W + F+ ++LIL+Q QW+ +
Sbjct 3392 DEHTPYDIGRQMLGVKLQGKFQSMFRWTLQWFAIIFVLTILILLQLAQWTFVGALPFTLL 3451
Query 3589 LPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMP---ASWVMRIMTWLE 3645
LP + LL+KHKH +L ++LLP AY+N Y P +++ + ++
Sbjct 3452 LPLIGFVAVCVGFVSLLIKHKHTYLTVYLLPVAMVTAYYNFQYTPEGVQGYLLSLYNYVN 3511
Query 3646 LADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALD 3705
+ G L ++ + A LL + R V DA R+W + + +Y + G+A
Sbjct 3512 PGRIDVIGTDLLTMLIISVACTLL---SVRMVRTDAYSRIWYVCTAVGWLYNCWTGSADT 3568
Query 3706 QAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGY 3765
AIS ++SV +NY+GV ++ A+ +V+V P + + +C+++ Y +GY
Sbjct 3569 VAISYLTFMVSVFTNYTGVACASLYAAQFMVWVLKFLDPTILLLYGRFRCVLVCYLLVGY 3628
Query 3766 CCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIG 3825
C CYFG+F L+NR FR TLG Y+Y+VS+QE RYMNS GLLPP +S A LNIKL GIG
Sbjct 3629 LCTCYFGVFNLINRLFRCTLGNYEYVVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIG 3688
Query 3826 GKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAF 3885
G P +V+T+QS M+D+KCTSVVLLSVLQQLRVESSSKLWA CV+LHN+IL + TEAF
Sbjct 3689 GIPIYRVSTIQSNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVKLHNEILASNSPTEAF 3748
Query 3886 EKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV 3945
E VSLLSVLLS+ GA++++ LC +L+N + LQA+ASEFS+L SY Y AQ+AY+ AV
Sbjct 3749 EAFVSLLSVLLSLPGAINLDELCSSILENNSVLQAVASEFSNLSSYVDYENAQKAYDTAV 3808
Query 3946 ANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSA 4005
A G + LKK++NVAKS D+D A RKLE+M++ AMT MYKQAR+ED+R+KVT+A
Sbjct 3809 ATGAPASTVNALKKAMNVAKSVLDKDVATTRKLERMSELAMTAMYKQARAEDRRSKVTAA 3868
Query 4006 MQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNT 4065
MQTMLF M+R+LD+DAL+NI+NNAR+G VPL +IP T A KL++VVPD+ Y T T
Sbjct 3869 MQTMLFNMIRRLDSDALSNILNNARNGVVPLGVIPRTAANKLLLVVPDFSVYTATITMPT 3928
Query 4066 FTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALR--ANSAVKLQNNELSP 4123
TYA + W++ QV DAD K V ++I +NS NLAWPL+VTA R A S VKLQNNEL P
Sbjct 3929 LTYAGSAWDVMQVADADGKTVNATDITRENSVNLAWPLVVTAQRQQATSPVKLQNNELMP 3988
Query 4124 VALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIY 4183
+++M+ AG +QTAC D A+AYYN +K GR V+A+L+D L +A+ KS G G +
Sbjct 3989 QTVKRMNVVAGVSQTACVTD-AVAYYNATKEGRHVMAILADTDGLAFAKVEKSTGDGFVI 4047
Query 4184 TELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTV 4243
ELEPPC+F+ DTPKGP +KYLYF KGL NL RG VLG+LA TVRL AG+ATEV +NS++
Sbjct 4048 LELEPPCKFMVDTPKGPALKYLYFTKGLKNLCRGTVLGTLACTVRLHAGSATEVASNSSI 4107
Query 4244 LSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASC 4303
LS C+F+VDP YKDYL +GG PI NCVKML HTGTG AIT P+AN+DQESFGGASC
Sbjct 4108 LSLCSFSVDPEATYKDYLDNGGSPIGNCVKMLTPHTGTGLAITAKPDANIDQESFGGASC 4167
Query 4304 CLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQL 4363
CLYCRCHI+HP G C KGK+VQIP NDP+GF +RN VC VC MW+GYGC C L
Sbjct 4168 CLYCRCHIEHPGASGVCKYKGKFVQIPLVGVNDPIGFCIRNVVCAVCNMWQGYGCPCSSL 4227
Query 4364 REPLMQSADASTFLNGFAV 4382
RE +Q+ D FLN V
Sbjct 4228 REINLQARD-ECFLNESGV 4245
>sp|P0C6W5|R1AB_BCHK9 Replicase polyprotein 1ab OS=Bat coronavirus
HKU9 OX=694006 GN=rep PE=1 SV=1
Length=6930
Score = 4360 bits (11307), Expect = 0.0, Method: Composition-based stats.
Identities = 1585/4455 (36%), Positives = 2368/4455 (53%), Gaps = 346/4455 (8%)
Query 28 VRGFGDSVEEALSEAREHLKNGTCGLVELEKGV--LPQLEQPYVFIKRSDALSTNHG-HK 84
V G+ +EEAL A++ L+ LV + + P + V I S +TN G
Sbjct 29 VTGWDIPIEEALEYAKQQLRTPEPQLVFVPYYLSHAPGISGDRVVITDSIWYATNFGWQP 88
Query 85 VVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYR-NVLLRKNGNKGAGGHSYGIDLKSY 143
+ EL + DG++YGR G T GVL+P + I ++ +RK G G +S L +
Sbjct 89 IRELAMDKDGVRYGRGG-THGVLLPMQDPSFIMGDIDIQIRK---YGIGANSPPDVLPLW 144
Query 144 DLGDELGTD--PIEDYEQNW---NTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPL 198
D + G D P D+ N K G L+ + DNN G +
Sbjct 145 DGFSDPGPDVGPYLDFPDNCCPTKPKAKRGGDVYLSDQYG-------FDNN-----GILV 192
Query 199 DCIKDFLARAGKSMCTLSEQLDYIESKR--GVYCCRDHEHEIAWFTERSDKSYEHQTPFE 256
+ + L KS TL + L + R Y D ++A R Q+ F
Sbjct 193 EPVMKLLGVI-KSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFT 251
Query 257 IKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGR-IRSVYPVASPQECNNM 315
+ + P + +P ++ V K G +G+ + +V + S NN
Sbjct 252 VVGVT-----EQLVPGYYYPFSTSSVVEH---TKPTRGGPVGKTVEAV--MLSLYGTNNY 301
Query 316 HLST---LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPA 372
+ +T +KC++CD W + CG E + ++C + V+K C
Sbjct 302 NPATPVARLKCSYCDYYGWTPLKDIGTVNCLCGAE---FQLTSSCVDAESAGVIKPGCVM 358
Query 373 CQDPEIGPEHSVADYHNHSNIETRLRKGGRTRC-FGGCVFAYVGCYNKRAYWVPRASADI 431
D G RL G RT FGG +++ +G N WVPRA + +
Sbjct 359 LLDKSPG---------------MRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIV 403
Query 432 GSGHTGITGD-NVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA-FID 489
H+G G + +N++L+E L I + D N A +A+ T A +
Sbjct 404 AGEHSGAVGSGDTVAINKELVEYLIE---GIRVDADTLDNPTCATFIANLDCDTKAPVVH 460
Query 490 TIKSLDYKSFKTIVESCGNYKVTKG-KPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIF 548
T++SL C K+ G KP+ + + L + Q A ++
Sbjct 461 TVESLQ--------GLCLANKIMLGDKPLP----TDEFHPFIVGL-AYHVQRACWYGALA 507
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY-VTGGLVQ 607
+RT +A D R + ++ VY + + AY V +
Sbjct 508 SRTFEAFR----DFVRTEEERFAQFFGKVCAPINGCVYLAYTTGRVTLFSAYQVLNTAIA 563
Query 608 QTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVA 667
++ + V+ L+PI EW+ K+S E L L F +VKG+ Q
Sbjct 564 KSKDAFGGVAAIVVDMLKPILEWVLKKMSIAKGAWLPYAEGLLALFKAQFTVVKGKFQFL 623
Query 668 SDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQL 727
++ D++ + + V AG K+ +L G + KG+ + ++L
Sbjct 624 RASLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALYTGTYYYFSRKGVLTEVQLCAKRL 683
Query 728 QLLM-PLKAPKEVTFLEGDSH-DTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCV 785
LL+ P + EV L+GD LT E+ G LE + D + GT V +
Sbjct 684 GLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGVLEEVFGASDV---KLVKGTLVSL 740
Query 786 NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFE 845
+ + +D Y + G + FRL+GG + VTFG++ V + V +++
Sbjct 741 ASKLFVRTEDGFLYRYVKSGGV-LGKAFRLRGGG-VSKVTFGDEEVHTIPNTVTVNFSYD 798
Query 846 LDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTN-----MGIDLDE 900
+ E +D +L++ + + VE GT++ + ACVV +AV + L DL ++ I+L++
Sbjct 799 VCEGLDAILDKVMAPFQVEEGTKLEDLACVVQKAVYERLS---DLFSDCPAELRPINLED 855
Query 901 WSVATFYLFDDAGEENFSSRMYCSF---YPPDEEEEDDAECEEEEIDETCEHEYGTEDDY 957
+ + +++ E+ MY S P D+E DD I++T E ++D +
Sbjct 856 FLTSECFVYSKDYEKILMPEMYFSLEDAVPVDDEMVDD-------IEDTVEQASDSDDQW 908
Query 958 QGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVA 1017
G +E + D+T + ++ GY K+ ++V
Sbjct 909 LG----------------DEGAEDCDNTIQDVDVATSMTTPC--------GYTKIAEHVY 944
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
IKC DIV+EA++ + V+VNAAN++L HGGGVAGALN+ATN AMQKES +YIK NG L
Sbjct 945 IKCADIVQEARNYSYAVLVNAANVNLHHGGGVAGALNRATNNAMQKESSEYIKANGSLQP 1004
Query 1078 GGSCLLSGHNLAKK-CLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKP 1136
GG LLS H LA LHVVGP+ G+D+ LL A Y + D +L PL+SAGIFG
Sbjct 1005 GGHVLLSSHGLASHGILHVVGPDKRLGQDLALLDAVYAAYTGFDSVLTPLVSAGIFGFTV 1064
Query 1137 LQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKS 1196
+SL V+ V Y+ V D+ LYE+ + D P+ E + +E
Sbjct 1065 EESLCSLVKNVACTTYVVVYDRQLYERALATSFDVPGPQSSVQHVPAIDWAEAVEVQESI 1124
Query 1197 VVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLL--LFADINGKLYHDSQNMLRGEDMSF 1254
V Q V+ +D V + + T + + + + D ++ +R
Sbjct 1125 VDQ----VETPSLGAVDTVDSNADSGLNETARSPENVVGSVPDDVVADVESCVRD----- 1175
Query 1255 LEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYT 1314
++ + +KKV D+ Q T
Sbjct 1176 ---------------------------------LVRQVVKKVKRDKRPPPIVPQ----QT 1198
Query 1315 LEEAKTALKKCKSAFYVLPSEAPNA---KEEILGTVSWNLREMLAHAEETRKLMPICMDV 1371
+E+ P E + ++ VS + M+ +E L+P+ +D
Sbjct 1199 VEQQ--------------PQEISSPGDCNTVLVDVVSMSFSAMVNFGKEKGLLIPVVIDY 1244
Query 1372 RAIMATIQRKYKGIKIQEGIVDY-GVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVT 1430
A + ++R +EG+ G F+ Y+ +P+ + LNSL PL+ +P G++
Sbjct 1245 PAFLKVLKR----FSPKEGLFSSNGYEFYGYSRDKPLHEVSKDLNSLGRPLIMIPFGFIV 1300
Query 1431 HGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLT---SSSKTSEEHFVETVSLAGSY 1487
+G L +A MR L P V V S +V Y Y S T+ + FV + L G+
Sbjct 1301 NGQTLAVSAVSMRGLTVPHTVVVPSESSVPLYRAYFNGVFSGDTTAVQDFVVDILLNGA- 1359
Query 1488 RDWSYSGQRTELGVE------FLKRGDKIVYHTLESPVEFHLDGEVL----SLDKLKSLL 1537
RDW +T V+ KRG+ Y + + + G+V+ ++ K ++ L
Sbjct 1360 RDWDV--LQTTCTVDRKVYKTICKRGN--TYLCFDDTNLYAITGDVVLKFATVSKARAYL 1415
Query 1538 SLR---EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKT 1594
+ IKV TTVD N T LV + +Y Q G + DG D + P EG
Sbjct 1416 ETKLCAPEPLIKVLTTVDGINYSTVLVSTAQSYRAQIGTVFCDGHDWSNKNPMPTDEGTH 1475
Query 1595 FFVLPSDDTLRSEAF-EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYL 1653
+ + + A EYY D + + R MS + W + V G + D+NCYL
Sbjct 1476 LYKQDNFSSAEVTAIREYYGVDDSNIIARAMSIRKTVQTWPYTVVDGRVLLAQRDSNCYL 1535
Query 1654 SSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLL 1713
+ + LQ ++V F+ P + AY + G+ +++A T G D ++ +L
Sbjct 1536 NVAISLLQDIDVSFSTPWVCRAYDALKGGNPLPMAEVLIALGKATPGVSDDAHMVLSAVL 1595
Query 1714 QHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQY 1773
H + +A+RV+ VC+HCG TG +A + G++ D+L VS+ C CGR A +Y
Sbjct 1596 NHGTV-TARRVMQTVCEHCGVSQMVFTGTDACTFYGSVVLDDLYAPVSVVCQCGRPAIRY 1654
Query 1774 LVQQESSFVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTK 1832
+ +Q+S +++MS P + L G + A + G GHY + + D +
Sbjct 1655 VSEQKSPWLLMSCTPTQVPLDTSGIWKTAIVFRGPVTAGHYMYAVNGTLISVYDANTRRR 1714
Query 1833 MSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLV 1892
S+ K P TD+ Y TS+T+ K +Y LDGV T I+P Y K+ + Y+T PI++V
Sbjct 1715 TSDLKLPATDILYGPTSFTSDSKVETYYLDGVKRTTIDPDFSKYVKRGDYYFTTAPIEVV 1774
Query 1893 PTQPLPNASFDNFKLT-CSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRH 1951
P S+D F L+ C N + A+ N+ TK +L +T +P++ GDVVAI +
Sbjct 1775 -AAPKLVTSYDGFYLSSCQNPQLAESFNKAINATKTGPMKL-LTMYPNVAGDVVAISDDN 1832
Query 1952 YSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWC-LRCLWSTKPVDTSNSFEVLAVEDT 2010
A G+ + KP+++ +PNTW L L ST V+T N+++VLAV+
Sbjct 1833 VVAH-PYGSLHMGKPVLFV---------TRPNTWKKLVPLLSTVVVNTPNTYDVLAVDPL 1882
Query 2011 QGMDNLACESQQPTSEEVVENPTIQKEVIEC-DVKTTEVVGNVILKPSDEG-VKVTQELG 2068
P + E E P K I +K T V+ P ++G + +E
Sbjct 1883 ------------PVNNETSEEPISVKAPIPLYGLKATMVLNGTTYVPGNKGHLLCLKEFT 1930
Query 2069 HEDLMAAYVENTS-ITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAA 2127
DL YVE + K + LS LGL+ + +N + + AY
Sbjct 1931 LTDLQTFYVEGVQPFVLLKASHLSKVLGLRV--SDSSLHVNHLSKGVVYAYA-------- 1980
Query 2128 ITTSNCAKRLAQRVFNNYMPYVFTL-LFQLCTFTKSTNS------------RIRASLPTT 2174
A RL RV + + + T + + F +STN ++
Sbjct 1981 ------ATRLTTRVTTSLLGGLVTRSVRKTADFVRSTNPGSKCVGLLCLFYQLFMRFWLL 2034
Query 2175 IAKNSVKSVAKL-CLDAG-------INYVK-------SPKFSKLFTIAMWLLLLSICLGS 2219
+ K + V+ + + G +NY++ + KL +++ + CL
Sbjct 2035 VKKPPIVKVSGIIAYNTGCGVTTCVLNYLRSRCGNISWSRLLKLLRYMLYIWFVWTCLT- 2093
Query 2220 LICVTAAFGVLLSNFGAPSYCNGVRE--LYLNSSNVTTMDFCEGSFPCSICLSGLDSLDS 2277
GV LS APS + + + ++ + +C++G+DSLD
Sbjct 2094 ------ICGVWLSEPYAPSLVTRFKYFLGIVMPCDYVLVNETGTGWLHHLCMAGMDSLD- 2146
Query 2278 YPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFIS 2337
YPAL Q S + T + + E AY+L+T ++G+ A++ + Y +
Sbjct 2147 YPALRMQQHRYGS-PYNYTYILMLLEAFFAYLLYTPALPIVGILAVLHLIVLYLPIP-LG 2204
Query 2338 NSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATR 2397
NSWL+ F+ I+++ P ++M+RMYI A + +K ++H+ GC + C+MCYK+N A R
Sbjct 2205 NSWLVVFLYYIIRLVPFTSMLRMYIVIAFLWLCYKGFLHVRYGCNNVACLMCYKKNVAKR 2264
Query 2398 VECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRP 2457
+EC+T+VNG+KR FYV ANGG FC HNWNC++CDT+ STFI +VA DLS QFKRP
Sbjct 2265 IECSTVVNGVKRMFYVNANGGTHFCTKHNWNCVSCDTYTVDSTFICRQVALDLSAQFKRP 2324
Query 2458 INPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLP-IN 2516
I TD++ Y V SV V+NG ++ YF+ GQ++YER P+ F N+ L + KG+ P N
Sbjct 2325 IIHTDEAYYEVTSVEVRNGYVYCYFESDGQRSYERFPMDAFTNVSKLHYSELKGAAPAFN 2384
Query 2517 VIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFS 2576
V+VFD ++ +E+A K+A++YY+QL C+PILL+D+ +V VGD ++ MF+AY +
Sbjct 2385 VLVFDATNRIEENAVKTAAIYYAQLACKPILLVDKRMVGVVGDDATIARAMFEAYAQNYL 2444
Query 2577 ATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVD--TDVDTKDVIECLKL 2634
+S+ M+K+K L +TA +++ G+ ++ VL FV + R D +DVDT D++ C++L
Sbjct 2445 LKYSIAMDKVKHLYSTALQQISSGMTVESVLKVFVGSTRAEAKDLESDVDTNDLVSCIRL 2504
Query 2635 SHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKD 2694
H E T DS NN + TY K + ++ ++G + NA+++NA +AK V+LIW D
Sbjct 2505 CHQEGWEWTTDSWNNLVPTYIKQDTLSTLEVGQFMTANAKYVNANIAKGAAVNLIWRYAD 2564
Query 2695 YMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGG--KIVSTCFKLMLK 2752
++ LSE +R+Q++ AA+K + +T ++ + V + T + GG +IVS L+
Sbjct 2565 FIKLSESMRRQLKVAARKTGLNLLVTTSSLKADVPCMVTPFKIIGGHRRIVSWRRVLIHV 2624
Query 2753 ATLLCVLA---ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHA 2809
LL VL YI+ P+ ++ +K I + V RDI S D CFANK +
Sbjct 2625 FMLLVVLNPQWFTPWYIMRPIEY---------NVVDFKVIDNAVIRDITSADQCFANKFS 2675
Query 2810 GFDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAV 2869
F+ W+S R GSY N + CP+V +++ +G +VPGLP LR + L + AV
Sbjct 2676 AFENWYSNRYGSYVNSRGCPMVVGVVSDIVGSLVPGLPARFLR-VGTTLLPLVNYGLGAV 2734
Query 2870 GNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDT 2929
G++CYTP I Y F TSACVLAA CT+F A G+ +PYC D L++ + Y L+P
Sbjct 2735 GSVCYTPHYAINYDVFDTSACVLAATCTLFSSASGERMPYCADAALIQNASRYDMLKPHV 2794
Query 2930 RYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHY 2988
Y + S I+FP V +V T EYC+ G C+ SE G+C+S RWV+NN ++
Sbjct 2795 MYPFYEHSGYIRFPEVIS-AGVHIVRTMAMEYCKVGRCDVSEAGLCMSLQPRWVVNNAYF 2853
Query 2989 RALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVF 3048
R SGV+CG A +L N+ P+ PVGA+D++ S++ G ++A++V+ + YY ++FRR F
Sbjct 2854 RQQSGVYCGTSAFDLFMNMLLPIFTPVGAVDITTSILMGALLAVVVSMSLYYLLRFRRAF 2913
Query 3049 GEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAM 3108
G+Y+ V+ N L F+++ +LCL Y LP +Y++ +LY T YF +D++ + H+ + M
Sbjct 2914 GDYSGVIFTNILAFVLNVIVLCLEGPYPMLPSIYAMVFLYATCYFGSDIACMMHVSFLIM 2973
Query 3109 FSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYL 3168
F+ +VP W+T +Y+ + +H WF + ++ V + F +F++AAL TF+L+KE++L
Sbjct 2974 FAGVVPLWVTVLYIVVVLSRHILWFASLCTKRTVQVGDLAFHSFQDAALQTFMLDKEVFL 3033
Query 3169 KLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQ 3228
+L+ E + Y +YLA+YNKYKY+SG +DT +YREAAC HL AL +SN G D +YQ
Sbjct 3034 RLKRE--ISSDAYFKYLAMYNKYKYYSGPMDTAAYREAACSHLVMALEKYSNGGGDTIYQ 3091
Query 3229 PPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAED 3288
PP+ S+ SA LQ+G +MA PSG VE C+V+V G+ TLNG+WLD+ V CPRHV+C+ ++
Sbjct 3092 PPRCSVASAALQAGLTRMAHPSGLVEPCLVKVNYGSMTLNGIWLDNFVICPRHVMCSRDE 3151
Query 3289 MLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQP 3348
+ NP+Y L +R +N+ F V +RVIGH+M+ LL+L VD +NPKTP Y F+R+
Sbjct 3152 LANPDYPRLSMRAANYDFHVSQNGHNIRVIGHTMEGSLLKLTVDVNNPKTPAYSFIRVST 3211
Query 3349 GQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELP 3408
GQ S+LACY+G P+GVY C +R N T++ SFL GSCGS GF ++ V FCY+H +ELP
Sbjct 3212 GQAMSLLACYDGLPTGVYTCTLRSNGTMRASFLCGSCGSPGFVMNGKEVQFCYLHQLELP 3271
Query 3409 TGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLN 3468
G H GTD G FYGPF D+Q Q A D TIT+NVLAWLYAAV++G+ WFL + + +
Sbjct 3272 NGTHTGTDFSGVFYGPFEDKQVPQLAAPDCTITVNVLAWLYAAVLSGENWFLTKSSISPA 3331
Query 3469 DFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILE 3528
+FN A+KY + +T + + +L PL+A+TGI+V M +ALK LL G GRTI+GS LE
Sbjct 3332 EFNNCAVKYMCQSVTSESLQVLQPLAAKTGISVERMLSALKVLLSAGFCGRTIMGSCSLE 3391
Query 3529 DEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAF 3588
DE TP+D+ RQ GV QGKF+ + + T W + F+ ++LIL+Q QW+ +
Sbjct 3392 DEHTPYDIGRQMLGVKLQGKFQSMFRWTLQWFAIIFVLTILILLQLAQWTFVGALPFTLL 3451
Query 3589 LPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMP---ASWVMRIMTWLE 3645
LP + LL+KHKH +L ++LLP AY+N Y P +++ + ++
Sbjct 3452 LPLIGFVAVCVGFVSLLIKHKHTYLTVYLLPVAMVTAYYNFQYTPEGVQGYLLSLYNYVN 3511
Query 3646 LADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALD 3705
+ G L ++ + A LL + R V DA R+W + + +Y + G+A
Sbjct 3512 PGRIDVIGTDLLTMLIISVACTLL---SVRMVRTDAYSRIWYVCTAVGWLYNCWTGSADT 3568
Query 3706 QAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGY 3765
AIS ++SV +NY+GV ++ A+ +V+V P + + +C+++ Y +GY
Sbjct 3569 VAISYLTFMVSVFTNYTGVACASLYAAQFMVWVLKFLDPTILLLYGRFRCVLVCYLLVGY 3628
Query 3766 CCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIG 3825
C CYFG+F L+NR FR TLG Y+Y+VS+QE RYMNS GLLPP +S A LNIKL GIG
Sbjct 3629 LCTCYFGVFNLINRLFRCTLGNYEYVVSSQELRYMNSHGLLPPTNSWQALMLNIKLAGIG 3688
Query 3826 GKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAF 3885
G P +V+T+QS M+D+KCTSVVLLSVLQQLRVESSSKLWA CV+LHN+IL + TEAF
Sbjct 3689 GIPIYRVSTIQSNMTDLKCTSVVLLSVLQQLRVESSSKLWALCVKLHNEILASNSPTEAF 3748
Query 3886 EKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAV 3945
E VSLLSVLLS+ GA++++ LC +L+N + LQA+ASEFS+L SY Y AQ+AY+ AV
Sbjct 3749 EAFVSLLSVLLSLPGAINLDELCSSILENNSVLQAVASEFSNLSSYVDYENAQKAYDTAV 3808
Query 3946 ANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSA 4005
A G + LKK++NVAKS D+D A RKLE+M++ AMT MYKQAR+ED+R+KVT+A
Sbjct 3809 ATGAPASTVNALKKAMNVAKSVLDKDVATTRKLERMSELAMTAMYKQARAEDRRSKVTAA 3868
Query 4006 MQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNT 4065
MQTMLF M+R+LD+DAL+NI+NNAR+G VPL +IP T A KL++VVPD+ Y T T
Sbjct 3869 MQTMLFNMIRRLDSDALSNILNNARNGVVPLGVIPRTAANKLLLVVPDFSVYTATITMPT 3928
Query 4066 FTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALR--ANSAVKLQNNELSP 4123
TYA + W++ QV DAD K V ++I +NS NLAWPL+VTA R A S VKLQNNEL P
Sbjct 3929 LTYAGSAWDVMQVADADGKTVNATDITRENSVNLAWPLVVTAQRQQATSPVKLQNNELMP 3988
Query 4124 VALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIY 4183
+++M+ AG +QTAC D A+AYYN +K GR V+A+L+D L +A+ KS G G +
Sbjct 3989 QTVKRMNVVAGVSQTACVTD-AVAYYNATKEGRHVMAILADTDGLAFAKVEKSTGDGFVI 4047
Query 4184 TELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTV 4243
ELEPPC+F+ DTPKGP +KYLYF KGL NL RG VLG+LA TVRL AG+ATEV +NS++
Sbjct 4048 LELEPPCKFMVDTPKGPALKYLYFTKGLKNLCRGTVLGTLACTVRLHAGSATEVASNSSI 4107
Query 4244 LSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASC 4303
LS C+F+VDP YKDYL +GG PI NCVKML HTGTG AIT P+AN+DQESFGGASC
Sbjct 4108 LSLCSFSVDPEATYKDYLDNGGSPIGNCVKMLTPHTGTGLAITAKPDANIDQESFGGASC 4167
Query 4304 CLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQL 4363
CLYCRCHI+HP G C KGK+VQIP NDP+GF +RN VC VC MW+GYGC C L
Sbjct 4168 CLYCRCHIEHPGASGVCKYKGKFVQIPLVGVNDPIGFCIRNVVCAVCNMWQGYGCPCSSL 4227
Query 4364 REPLMQSADASTFLN 4378
RE +Q+ D FLN
Sbjct 4228 REINLQARD-ECFLN 4241
>sp|P0C6U1|R1A_CVBQ Replicase polyprotein 1a OS=Bovine coronavirus
(strain Quebec) OX=11133 GN=1a PE=3 SV=1
Length=4383
Score = 3743 bits (9705), Expect = 0.0, Method: Composition-based stats.
Identities = 1312/4435 (30%), Positives = 2053/4435 (46%), Gaps = 388/4435 (9%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P IA + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIAPWVMYLRKCGEKGAYIKDYKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCEH-CGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A + + +LD VD++ L + ++ +A Q
Sbjct 603 DYAGKICHAVVSKSKELLD-------VSVDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYF-GKNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVTI---AGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + + G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSGAKVGLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP K ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKTKQKGIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RCVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C + V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGEFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEI----------- 943
L + + +LFD+AGEE + ++YC+F P++++ + EE+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAPEDDDFLEESGVEEDDVEGEETDLTVT 990
Query 944 ---DETCEHEYGTEDDYQGLPLEFG--ASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPT 998
+ E + L+ G +VEE+ + D +
Sbjct 991 SAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVQMSDFGDLESVIQDYENVCFE 1050
Query 999 PEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA---------------------------N 1031
+F L L A + ++ +
Sbjct 1051 FYTTEPEFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLF 1110
Query 1032 PMVIVN--AANIHLKHGGGVAGALNKATNGAMQKESD-DYIKLNGPLTVGGSCLLSGHNL 1088
+VN ANI + GG VA D + + + L G +
Sbjct 1111 VDTLVNKIPANIVVPQGGYVAD-----FAYWFLTLCDWQCVAYWKCIKCDLALKLKGLDA 1165
Query 1089 AKKCLHVVGPNLNAGEDIQLLKA-----AYENFNSQDILLAPLLSAGIFGAKPLQSLQVC 1143
VV GE + L+ A+ + + +
Sbjct 1166 MFFYGDVVSHVCKCGESMVLIDVDVPFTAHFALKDKLFCAF-------ITKRSVYKAACV 1218
Query 1144 VQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEE-----KSVV 1198
V + V+ K + + + + + T + +V
Sbjct 1219 VDVNDSHSMAVVDGKQIDDHRITSITSDKFDFIIGHGTSFSMTTFEIAQLYGSCITPNVC 1278
Query 1199 QKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKD 1258
D+ K EV + + + E ++
Sbjct 1279 FVKGDIIKVSKRVKAEVVVNPANGHMAHG-----GGVAKAIAVAAGQQFVKETTDMVKSK 1333
Query 1259 APYMVGDV-ITSGDITC-----VVIPSKKA--GGTTEMLSRALKKV-PVDEYITTYPGQG 1309
GD +++G C VV P + + +L R K + D +TT G
Sbjct 1334 GVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISAG 1393
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLM--PI 1367
+ + T L VL S + I + AE + I
Sbjct 1394 IFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLISKCQITAVEGTKKLAERLSFNVGRSI 1453
Query 1368 CMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIG 1427
+ A + F ++ + +++
Sbjct 1454 VYETDANKLILSNDVA----------------FVSTFNVLQDVLS--------------- 1482
Query 1428 YVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSY 1487
+ H L++ AR V P+ N + + ++F
Sbjct 1483 -LRHDIALDDDARTFVQSNVDVV-----PEGWRVVNKFYQINGVRPVKYF---------- 1526
Query 1488 RDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKV 1547
G++ + Y S + ++ ++K+L + + +
Sbjct 1527 --------ECPGGIDICSQDKVFGYVQQGSFNK-------ATVAQIKALF----LDKVDI 1567
Query 1548 FTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSE 1607
TVD N + V + ++G+ G + DG +VTK K +N++GK FF + + +
Sbjct 1568 LLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQFDNLSSEDLK 1627
Query 1608 AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKF 1667
A D+ L Y + L + KW+ G + K A+NNC+++ L LQ L +KF
Sbjct 1628 AVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQSLNLKF 1687
Query 1668 NAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNV 1727
QEA+ R+G A F +L+LA G+ D R+ + + +L A +
Sbjct 1688 KIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGAICDFEI 1747
Query 1728 VCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAP 1787
CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F++ S
Sbjct 1748 ACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPFLICSNT 1805
Query 1788 PAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFY-K 1846
PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++D Y K
Sbjct 1806 PASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLSDCLYLK 1863
Query 1847 ETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLPNASFDNF 1905
T +Y LD V E +P L YY YYT++ I T + + NF
Sbjct 1864 NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKVDGVYTNF 1923
Query 1906 KLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLH 1964
KL D LN GF + E VT +P GDVV Y +++G
Sbjct 1924 KLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYERGCITFG 1981
Query 1965 KPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT 2024
KP++W ++ + + + +P+ + + D ES
Sbjct 1982 KPVIWLSHEQASLNSLT---------YFNRPLLVDENKFDVLKVDDVDDGGDISESDAKE 2032
Query 2025 SEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITI 2084
+E+ I+ ++ K +V +VI+ +K + L D+ ++ +
Sbjct 2033 PKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDMWLTGCRCVV 2086
Query 2085 KKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRV--F 2142
+ N LS A+ + TI + V L + N K + ++
Sbjct 2087 RTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LNLREIKPVFNVVKAVRNKISAC 2141
Query 2143 NNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSK 2202
N++ ++F LLF + + T +A K KL A N + K+S
Sbjct 2142 FNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVALAFKNAFLTFKWSV 2194
Query 2203 LFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELYLNSSNVTT----- 2255
+ A + + + + I F L G P++ + + N+ ++ T
Sbjct 2195 VARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIVQWIKNTFSLVTICDLY 2254
Query 2256 --------MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISS--YKLDLTILGLAAEWV 2305
+C GS C CL+G D LD+Y A++ +Q + +L + E +
Sbjct 2255 SIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFVDYTGVLKIVIELI 2314
Query 2306 LAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIF 2363
++Y L+T +FY L +Q+ + + ++ W + ++S+ M P +R YI
Sbjct 2315 VSYALYTAWFYPLFALISIQILTTWLPELLMLSTLHWSVRLLVSLANMLPAHVFMRFYII 2374
Query 2364 FASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK 2423
ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R + V ANGG GFC
Sbjct 2375 IASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIRYYDVMANGGTGFCS 2434
Query 2424 THNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFD 2483
H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V V + L++D
Sbjct 2435 KHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTDVKQVGCYMRLFYD 2494
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+ GQ+TY+ S FV+ NL + K ++V+V + + D++ +A+V+Y+Q +
Sbjct 2495 RDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKANFLNAAVFYAQSLF 2552
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+ATAHS + +G +
Sbjct 2553 RPILMVDKILITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALIATAHSSIKQGTQI 2612
Query 2604 DGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTP 2662
VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN + TY K +N+
Sbjct 2613 CKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNNLVPTYLKGDNIVA 2672
Query 2663 RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCA 2722
DLG I +A+H+ VAK VS IW+V + LS + +++ A K + LT
Sbjct 2673 ADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKACCKTGLKLELTYN 2732
Query 2723 TTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNE 2782
V+V+TT SLKGG + S + +L+C + + +MP +T+ D
Sbjct 2733 KQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI---GLWCLMPTYTVHKSDFQLPV 2789
Query 2783 IIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIG 2840
YK + +GV RD+ D CFANK FD W+ G Y N +CP+V A++ ++ G
Sbjct 2790 YASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVVDQDFG 2849
Query 2841 FIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFK 2900
V +P VLR LHF+ SA G CYTP I YS+F S CVL++ CT+F
Sbjct 2850 STVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYSNFYASGCVLSSACTMFA 2908
Query 2901 DAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFPNTYLEGSVRVVTTFDAE 2959
A G P PYCY L++ + YS L P RY L + I+ P EG VR+V T
Sbjct 2909 MADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRLPEVLREGLVRIVRTRSMS 2968
Query 2960 YCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALD 3019
YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +LI +F L QPV L
Sbjct 2969 YCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFKGLAQPVDFLA 3028
Query 3020 VSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLP 3079
++AS +AG I+A++V YY +K +R FG+Y +V N +++ ++F +L + Y L
Sbjct 3029 LTASSIAGAILAVIVVLGFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMMLFVFQVYPTLS 3088
Query 3080 GVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLR 3139
VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+ + H W F+
Sbjct 3089 CVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNHAFWVFSYC-- 3146
Query 3140 KRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALD 3199
+++ + + TFEE AL TF++ K+ Y KL++ L +NRYL+LYNKY+Y+SG +D
Sbjct 3147 RQLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRYLSLYNKYRYYSGKMD 3204
Query 3200 TTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMV 3258
T +YREAAC LAKA++ F +N+G+DVLYQPP S++++ LQSG KM P+ KVE C+V
Sbjct 3205 TAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQSGIVKMVNPTSKVEPCIV 3264
Query 3259 QVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVI 3318
VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R ++ F V + L V+
Sbjct 3265 SVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRVTSSDFTVLFDRLSLTVM 3324
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
+ MQ C+L L V N +TPKY F ++PG+TF+VLA YNG P G + MR ++TIKG
Sbjct 3325 SYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGKPQGAFHVTMRSSYTIKG 3384
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ I DCV F YMH +EL TG H GTD G FYGP+ D Q Q D
Sbjct 3385 SFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDFNGDFYGPYKDAQVVQLPVQDY 3444
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
++N +AWLYAA++N WF+ ++ DFN+ A+ + + D V + L++ TG
Sbjct 3445 IQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQVKSDLV--IDALASMTG 3502
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
+++ + AA+K L +NG GR I+GS EDE TP DV +Q +G+ Q K ++VKG
Sbjct 3503 VSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQQLAGIKLQSKRTRLVKGIVC 3561
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ + I+ +W++F +V N L T + + + AMLLVKHKH +L ++++
Sbjct 3562 WIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCVISLAMLLVKHKHLYLTMYII 3620
Query 3619 PSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTART 3676
P L T+ Y N +V ++ + WL S+ Y D V+Y L++ ++ +T R+
Sbjct 3621 PVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDEVIYGMLLLIGMVFVTLRS 3679
Query 3677 VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIV 3736
+ D + + VI++V Y G+ L++ I + ++ S+ Y+ M A+ I
Sbjct 3680 INHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLFGTYTWTTALSMAAAKVIA 3737
Query 3737 FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQE 3796
V L F ++ +++ Y F+GY CY+GLF L+N FR+ LGVY+Y +S QE
Sbjct 3738 -KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLMNSLFRMPLGVYNYKISVQE 3796
Query 3797 FRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQL 3856
RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QSK++DVKC + LL+ LQ L
Sbjct 3797 LRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQSKLTDVKCANGGLLNCLQHL 3856
Query 3857 RVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEE 3910
V S+SKLW C LHN+IL D AFEK+ LL VL + AVD I +C++
Sbjct 3857 HVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDSKCLTSIEEVCDD 3916
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFD 3969
+ LQA+ SEF ++ S+ Y A++ ++A ++G + + LK+L+K+ N+AKS ++
Sbjct 3917 YAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSSGSANQQQLKQLEKACNIAKSAYE 3976
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA
Sbjct 3977 RDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNA 4036
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLS 4089
GCVPLN IP A L ++VPD Y D TYA +W+IQ + D+D QL
Sbjct 4037 VKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLH 4096
Query 4090 EINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALA 4147
EI S + WPL++ A R N SA LQNNEL P L+ +G QT T
Sbjct 4097 EI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKTQVVNSGPDQTCNTPTQ--C 4150
Query 4148 YYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYF 4207
YYNNS G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF
Sbjct 4151 YYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDPPCKFTVQDVKGLKIKYLYF 4209
Query 4208 IKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQP 4267
+KG N L RG V+G++++TVRLQAG ATE +NS++LS CAF+VDP K Y D++ GG P
Sbjct 4210 VKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTP 4269
Query 4268 ITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYV 4327
I NCVKMLC H GTG AITV P+A Q+S+GGAS C+YCR ++HP+ G C L+GK+V
Sbjct 4270 IANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHPDVDGLCKLRGKFV 4329
Query 4328 QIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
Q+P DPV + L + VC VCG W+ CSC + +QS D + FLNGF V
Sbjct 4330 QVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTTVQSKD-TNFLNGFGV 4381
>sp|P0C6X0|R1AB_CVBQ Replicase polyprotein 1ab OS=Bovine coronavirus
(strain Quebec) OX=11133 GN=rep PE=3 SV=1
Length=7059
Score = 3740 bits (9699), Expect = 0.0, Method: Composition-based stats.
Identities = 1309/4431 (30%), Positives = 2050/4431 (46%), Gaps = 388/4431 (9%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P IA + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIAPWVMYLRKCGEKGAYIKDYKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCEH-CGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A + + +LD VD++ L + ++ +A Q
Sbjct 603 DYAGKICHAVVSKSKELLD-------VSVDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYF-GKNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVTI---AGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + + G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSGAKVGLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP K ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKTKQKGIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RCVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C + V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGEFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEI----------- 943
L + + +LFD+AGEE + ++YC+F P++++ + EE+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAPEDDDFLEESGVEEDDVEGEETDLTVT 990
Query 944 ---DETCEHEYGTEDDYQGLPLEFG--ASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPT 998
+ E + L+ G +VEE+ + D +
Sbjct 991 SAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVQMSDFGDLESVIQDYENVCFE 1050
Query 999 PEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA---------------------------N 1031
+F L L A + ++ +
Sbjct 1051 FYTTEPEFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLF 1110
Query 1032 PMVIVN--AANIHLKHGGGVAGALNKATNGAMQKESD-DYIKLNGPLTVGGSCLLSGHNL 1088
+VN ANI + GG VA D + + + L G +
Sbjct 1111 VDTLVNKIPANIVVPQGGYVAD-----FAYWFLTLCDWQCVAYWKCIKCDLALKLKGLDA 1165
Query 1089 AKKCLHVVGPNLNAGEDIQLLKA-----AYENFNSQDILLAPLLSAGIFGAKPLQSLQVC 1143
VV GE + L+ A+ + + +
Sbjct 1166 MFFYGDVVSHVCKCGESMVLIDVDVPFTAHFALKDKLFCAF-------ITKRSVYKAACV 1218
Query 1144 VQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEE-----KSVV 1198
V + V+ K + + + + + T + +V
Sbjct 1219 VDVNDSHSMAVVDGKQIDDHRITSITSDKFDFIIGHGTSFSMTTFEIAQLYGSCITPNVC 1278
Query 1199 QKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKD 1258
D+ K EV + + + E ++
Sbjct 1279 FVKGDIIKVSKRVKAEVVVNPANGHMAHG-----GGVAKAIAVAAGQQFVKETTDMVKSK 1333
Query 1259 APYMVGDV-ITSGDITC-----VVIPSKKA--GGTTEMLSRALKKV-PVDEYITTYPGQG 1309
GD +++G C VV P + + +L R K + D +TT G
Sbjct 1334 GVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLISAG 1393
Query 1310 CAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLM--PI 1367
+ + T L VL S + I + AE + I
Sbjct 1394 IFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLISKCQITAVEGTKKLAERLSFNVGRSI 1453
Query 1368 CMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIG 1427
+ A + F ++ + +++
Sbjct 1454 VYETDANKLILSNDVA----------------FVSTFNVLQDVLS--------------- 1482
Query 1428 YVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSY 1487
+ H L++ AR V P+ N + + ++F
Sbjct 1483 -LRHDIALDDDARTFVQSNVDVV-----PEGWRVVNKFYQINGVRPVKYF---------- 1526
Query 1488 RDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKV 1547
G++ + Y S + ++ ++K+L + + +
Sbjct 1527 --------ECPGGIDICSQDKVFGYVQQGSFNK-------ATVAQIKALF----LDKVDI 1567
Query 1548 FTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSE 1607
TVD N + V + ++G+ G + DG +VTK K +N++GK FF + + +
Sbjct 1568 LLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCDINYKGKVFFQFDNLSSEDLK 1627
Query 1608 AFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKF 1667
A D+ L Y + L + KW+ G + K A+NNC+++ L LQ L +KF
Sbjct 1628 AVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQANNNCFVNVSCLMLQSLNLKF 1687
Query 1668 NAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNV 1727
QEA+ R+G A F +L+LA G+ D R+ + + +L A +
Sbjct 1688 KIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRDFLRVVFSQVDLTGAICDFEI 1747
Query 1728 VCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAP 1787
CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG+ + V+ + F++ S
Sbjct 1748 ACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCGKKLI-HCVRFDVPFLICSNT 1805
Query 1788 PAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFY-K 1846
PA KL +G AN + G+ + GHY H+ +++ D +++ K+++ G ++D Y K
Sbjct 1806 PASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDASNVKKVTDVTGNLSDCLYLK 1863
Query 1847 ETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDL-VPTQPLPNASFDNF 1905
T +Y LD V E +P L YY YYT++ I T + + NF
Sbjct 1864 NLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQRIIKAQFKTFEKVDGVYTNF 1923
Query 1906 KLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLH 1964
KL D LN GF + E VT +P GDVV Y +++G
Sbjct 1924 KLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDVVLATDDLYVKRYERGCITFG 1981
Query 1965 KPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPT 2024
KP++W ++ + + + +P+ + + D ES
Sbjct 1982 KPVIWLSHEQASLNSLT---------YFNRPLLVDENKFDVLKVDDVDDGGDISESDAKE 2032
Query 2025 SEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITI 2084
+E+ I+ ++ K +V +VI+ +K + L D+ ++ +
Sbjct 2033 PKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYVKSLSIVDVYDMWLTGCRCVV 2086
Query 2085 KKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRV--F 2142
+ N LS A+ + TI + V L + N K + ++
Sbjct 2087 RTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LNLREIKPVFNVVKAVRNKISAC 2141
Query 2143 NNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSK 2202
N++ ++F LLF + + T +A K KL A N + K+S
Sbjct 2142 FNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KLTCKLVALAFKNAFLTFKWSV 2194
Query 2203 LFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYCNGVRELYLNSSNVTT----- 2255
+ A + + + + I F L G P++ + + N+ ++ T
Sbjct 2195 VARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFVGKIVQWIKNTFSLVTICDLY 2254
Query 2256 --------MDFCEGSFPCSICLSGLDSLDSYPALETIQVTISS--YKLDLTILGLAAEWV 2305
+C GS C CL+G D LD+Y A++ +Q + +L + E +
Sbjct 2255 SIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYEADRRAFVDYTGVLKIVIELI 2314
Query 2306 LAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIF 2363
++Y L+T +FY L +Q+ + + ++ W + ++S+ M P +R YI
Sbjct 2315 VSYALYTAWFYPLFALISIQILTTWLPELLMLSTLHWSVRLLVSLANMLPAHVFMRFYII 2374
Query 2364 FASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK 2423
ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TIV GM R + V ANGG GFC
Sbjct 2375 IASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTIVGGMIRYYDVMANGGTGFCS 2434
Query 2424 THNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFD 2483
H WNC++CD++ G+TFI+ E A DLS + KRPI PTD + + V V + L++D
Sbjct 2435 KHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDVAYHTVTDVKQVGCYMRLFYD 2494
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+ GQ+TY+ S FV+ NL + K ++V+V + + D++ +A+V+Y+Q +
Sbjct 2495 RDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVENDA--DKANFLNAAVFYAQSLF 2552
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PIL++D+ L++ T V+ MFD YVDTF + F V + L AL+ATAHS + +G +
Sbjct 2553 RPILMVDKILITTANTGTSVTETMFDVYVDTFLSMFDVDKKSLNALIATAHSSIKQGTQI 2612
Query 2604 DGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTP 2662
VL TF+S AR+ +D+DVDTK + + + + + LE+T +SCNN + TY K +N+
Sbjct 2613 CKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLELTDESCNNLVPTYLKGDNIVA 2672
Query 2663 RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCA 2722
DLG I +A+H+ VAK VS IW+V + LS + +++ A K + LT
Sbjct 2673 ADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDFQHKLKKACCKTGLKLELTYN 2732
Query 2723 TTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNE 2782
V+V+TT SLKGG + S + +L+C + + +MP +T+ D
Sbjct 2733 KQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI---GLWCLMPTYTVHKSDFQLPV 2789
Query 2783 IIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIG 2840
YK + +GV RD+ D CFANK FD W+ G Y N +CP+V A++ ++ G
Sbjct 2790 YASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLSYYSNSMACPIVVAVVDQDFG 2849
Query 2841 FIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFK 2900
V +P VLR LHF+ SA G CYTP I YS+F S CVL++ CT+F
Sbjct 2850 STVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQISYSNFYASGCVLSSACTMFA 2908
Query 2901 DAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SIIQFPNTYLEGSVRVVTTFDAE 2959
A G P PYCY L++ + YS L P RY L + I+ P EG VR+V T
Sbjct 2909 MADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFIRLPEVLREGLVRIVRTRSMS 2968
Query 2960 YCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALD 3019
YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D +LI +F L QPV L
Sbjct 2969 YCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRDVFDLIYQLFKGLAQPVDFLA 3028
Query 3020 VSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLP 3079
++AS +AG I+A++V YY +K +R FG+Y +V N +++ ++F +L + Y L
Sbjct 3029 LTASSIAGAILAVIVVLGFYYLIKLKRAFGDYTSIVFVNVIVWCVNFMMLFVFQVYPTLS 3088
Query 3080 GVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLR 3139
VY++ Y Y T YF +++S + HLQW M+ I+P W +Y+ + H W F+
Sbjct 3089 CVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCLLYISVVVSNHAFWVFSYC-- 3146
Query 3140 KRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALD 3199
+++ + + TFEE AL TF++ K+ Y KL++ L +NRYL+LYNKY+Y+SG +D
Sbjct 3147 RQLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDVAFNRYLSLYNKYRYYSGKMD 3204
Query 3200 TTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMV 3258
T +YREAAC LAKA++ F +N+G+DVLYQPP S++++ LQSG KM P+ KVE C+V
Sbjct 3205 TAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSFLQSGIVKMVNPTSKVEPCIV 3264
Query 3259 QVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVI 3318
VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL R ++ F V + L V+
Sbjct 3265 SVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLLCRVTSSDFTVLFDRLSLTVM 3324
Query 3319 GHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKG 3378
+ MQ C+L L V N +TPKY F ++PG+TF+VLA YNG P G + MR ++TIKG
Sbjct 3325 SYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAYNGKPQGAFHVTMRSSYTIKG 3384
Query 3379 SFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT 3438
SFL GSCGSVG+ I DCV F YMH +EL TG H GTD G FYGP+ D Q Q D
Sbjct 3385 SFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDFNGDFYGPYKDAQVVQLPVQDY 3444
Query 3439 TITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTG 3498
++N +AWLYAA++N WF+ ++ DFN+ A+ + + D V + L++ TG
Sbjct 3445 IQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNGFSQVKSDLV--IDALASMTG 3502
Query 3499 IAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHH 3558
+++ + AA+K L +NG GR I+GS EDE TP DV +Q +G+ Q K ++VKG
Sbjct 3503 VSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQQLAGIKLQSKRTRLVKGIVC 3561
Query 3559 WMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLL 3618
W++ + I+ +W++F +V N L T + + + AMLLVKHKH +L ++++
Sbjct 3562 WIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCVISLAMLLVKHKHLYLTMYII 3620
Query 3619 PSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTART 3676
P L T+ Y N +V ++ + WL S+ Y D V+Y L++ ++ +T R+
Sbjct 3621 PVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYTDEVIYGMLLLIGMVFVTLRS 3679
Query 3677 VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIV 3736
+ D + + VI++V Y G+ L++ I + ++ S+ Y+ M A+ I
Sbjct 3680 INHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLASLFGTYTWTTALSMAAAKVIA 3737
Query 3737 FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQE 3796
V L F ++ +++ Y F+GY CY+GLF L+N FR+ LGVY+Y +S QE
Sbjct 3738 -KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSLMNSLFRMPLGVYNYKISVQE 3796
Query 3797 FRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQL 3856
RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ QSK++DVKC + LL+ LQ L
Sbjct 3797 LRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQSKLTDVKCANGGLLNCLQHL 3856
Query 3857 RVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEE 3910
V S+SKLW C LHN+IL D AFEK+ LL VL + AVD I +C++
Sbjct 3857 HVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLFANPAAVDSKCLTSIEEVCDD 3916
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFD 3969
+ LQA+ SEF ++ S+ Y A++ ++A ++G + + LK+L+K+ N+AKS ++
Sbjct 3917 YAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSSGSANQQQLKQLEKACNIAKSAYE 3976
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA
Sbjct 3977 RDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNA 4036
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLS 4089
GCVPLN IP A L ++VPD Y D TYA +W+IQ + D+D QL
Sbjct 4037 VKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYAGNVWQIQTIQDSDGTNKQLH 4096
Query 4090 EINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALA 4147
EI S + WPL++ A R N SA LQNNEL P L+ +G QT T
Sbjct 4097 EI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLKTQVVNSGPDQTCNTPTQ--C 4150
Query 4148 YYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYF 4207
YYNNS G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF
Sbjct 4151 YYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELDPPCKFTVQDVKGLKIKYLYF 4209
Query 4208 IKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQP 4267
+KG N L RG V+G++++TVRLQAG ATE +NS++LS CAF+VDP K Y D++ GG P
Sbjct 4210 VKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLCAFSVDPKKTYLDFIQQGGTP 4269
Query 4268 ITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYV 4327
I NCVKMLC H GTG AITV P+A Q+S+GGAS C+YCR ++HP+ G C L+GK+V
Sbjct 4270 IANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHPDVDGLCKLRGKFV 4329
Query 4328 QIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
Q+P DPV + L + VC VCG W+ CSC + +QS D + FLN
Sbjct 4330 QVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTTVQSKD-TNFLN 4377
>sp|K9N638|R1A_MERS1 Replicase polyprotein 1a OS=Middle East respiratory
syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
OX=1263720 GN=1a PE=1 SV=1
Length=4391
Score = 3734 bits (9682), Expect = 0.0, Method: Composition-based stats.
Identities = 1243/3411 (36%), Positives = 1890/3411 (55%), Gaps = 194/3411 (6%)
Query 1109 LKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVY----IAVNDKALYEQV 1164
++ + + + P++S + + L QT++ +V + D + V
Sbjct 1036 VEDIAQVVIADTLQETPVVSDTVEVPPQVVKLPSEPQTIQPEVKEVAPVYEADTEQTQSV 1095
Query 1165 VMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKF 1224
+ R+ + +P + + K + V D K + V T
Sbjct 1096 TVK-----PKRLRKKRNVDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHL 1150
Query 1225 LTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS------GDITCVVIP 1278
I G + S+ ++ E ++ P VGD + +I VV P
Sbjct 1151 KHG-----GGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGP 1205
Query 1279 SKKAGGTTEMLSRALKK---VPVDEYITTYPGQGCAG--------YTLEEAKTALKKCKS 1327
+A +LS+ K P+ +T G G Y + EAKT + +
Sbjct 1206 DARAKQDVSLLSKCYKAMNAYPL--VVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVN 1263
Query 1328 AFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKI 1387
+ V S + L LR + A++ + +C D A ++ K
Sbjct 1264 SQDVYKSLTIVDIPQSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNKGVDYTK 1323
Query 1388 QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKA 1447
+ VD GV+++ YTSK+ + I+ + N + +++MP+GYV+HG +L +A +R +
Sbjct 1324 KFLTVD-GVQYYCYTSKDTLDDILQQANK-SVGIISMPLGYVSHGLDLIQAGSVVRRVNV 1381
Query 1448 PAVVSVSSPDAVTTYNGYLTSSSK--TSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLK 1505
P V +++ + L S E F++ V G Y W EL V+ L+
Sbjct 1382 PYVCLLANKEQ----EAILMSEDVKLNPSEDFIKHVRTNGGYNSWHLV--EGELLVQDLR 1435
Query 1506 RGDKI------------VYHTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIKVFTTV 1551
+ V++ +++ F + +L ++ L R + TI+V TV
Sbjct 1436 LNKLLHWSDQTICYKDSVFYVVKNSTAFPFE----TLSACRAYLDSRTTQQLTIEVLVTV 1491
Query 1552 DNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF-E 1610
D N T +++ TY Q G + +GAD++ P G + ++ + ++A E
Sbjct 1492 DGVNFRTVVLNNKNTYRSQLGCVFFNGADISDTIPDEKQNGHSLYLADNLTADETKALKE 1551
Query 1611 YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLE-VKFNA 1669
Y +D +FL R+ S KWK + S+K +DNNCYL++V++ L L+ +KF
Sbjct 1552 LYGPVDPTFLHRFYSLKAAVHKWKMVVCDKVRSLKLSDNNCYLNAVIMTLDLLKDIKFVI 1611
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SAKRVLNVV 1728
PALQ A+ + + GD+ +F ALI+AY N T G D + +L A L SA+ V
Sbjct 1612 PALQHAFMKHKGGDSTDFIALIMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREW 1671
Query 1729 CKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPP 1788
C CG K L G++A Y+G + ++L+ ++ C CG + + +V+ + ++++S P
Sbjct 1672 CNVCGIKDVVLQGLKACCYVGVQTVEDLRARMTYVCQCGGERHRQIVEHTTPWLLLSGTP 1731
Query 1789 AEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEYKGPVTDV 1843
E + T F+ N + G GHY H K L + D ++K S++K VTDV
Sbjct 1732 NEKLVTTSTAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTSDWKCKVTDV 1791
Query 1844 FYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYT-EQPIDLVPTQPLPNASF 1902
+ Y++ V Y LDG TE++P L +Y KD Y+T E P+ P L + +
Sbjct 1792 LFPGQKYSSDCNVVRYSLDGNFRTEVDPDLSAFYVKDGKYFTSEPPVTYSPATILAGSVY 1851
Query 1903 DNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAIDYRHYSAS 1955
N L S+ + D N + GF +KP +++ + +F P +GDV+ ++ Y
Sbjct 1852 TNSCLVSSDGQPGGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPI 1911
Query 1956 FKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDN 2015
+K GA KPI+W + K N LR ++ P++ N F L+VE T
Sbjct 1912 YKNGAMYKGKPILWVNKASYDTNLNKFNRASLRQIFDVAPIELENKFTPLSVEST----- 1966
Query 2016 LACESQQPTSEEVVENPTIQKE--VIECD-VKTTEVVGNVILKPSDEGVKVTQELGHEDL 2072
P V+ +Q+E +++C + V NV D G V + L EDL
Sbjct 1967 -------PVEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVSFVADDSGTPVVEYLSKEDL 2019
Query 2073 MAAYVE-NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAI--- 2128
YV+ + + K N LS L L T+ + IN V S L L +A+
Sbjct 2020 HTLYVDPKYQVIVLKDNVLSSMLRLHTVES---GDINVVAASGSLTRKVKLLFRASFYFK 2076
Query 2129 -----------TTSNCAKRLAQRV---------FNNYMPYVFTLLFQLCTFTKSTNSRIR 2168
+C K + + + +++ +F L + +K + ++
Sbjct 2077 EFATRTFTATTAVGSCIKSVVRHLGVTKGILTGCFSFVKMLFMLPLAYFSDSKLGTTEVK 2136
Query 2169 ASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTA 2225
S T + N VK +D ++ ++ + + + L + L S+ +
Sbjct 2137 VSALKTAGVVTGNVVKQCCTAAVDLSMDKLRRVDWKSTLRLLLMLCTTMVLLSSVYHLYV 2196
Query 2226 AFGVLLSN-------------------FGAPSYCNGVRELY-LNSSNVTTMDFCEG-SFP 2264
VL S+ G S C+G+ Y NS +V T FC S
Sbjct 2197 FNQVLSSDVMFEDAQGLKKFYKEVRAYLGISSACDGLASAYRANSFDVPT--FCANRSAM 2254
Query 2265 CSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIM 2324
C+ CL DS+ YPAL+ +Q +S Y L++ L A E LAYML+T F L L+ +
Sbjct 2255 CNWCLISQDSITHYPALKMVQTHLSHYVLNIDWLWFAFETGLAYMLYTSAFNWLLLAGTL 2314
Query 2325 QVFFGY------FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIM 2378
FF + S+ + S W I P++ +VRMY A + + K Y H++
Sbjct 2315 HYFFAQTSIFVDWRSYNYAVSSAFWLFTHI----PMAGLVRMYNLLACLWLLRKFYQHVI 2370
Query 2379 DGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTG 2438
+GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG FC+ HNWNC++CDT G
Sbjct 2371 NGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDTAGVG 2430
Query 2439 STFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHF 2498
+TFI +EVA DL+ +RPIN TD+S Y VDSV VK + + + GQ YER PL F
Sbjct 2431 NTFICEEVANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPFYERFPLCAF 2490
Query 2499 VNLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALV 2554
NLD L+ T G N I++D + ES ++SA VYYSQ++C+ ILL+D +LV
Sbjct 2491 TNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLV 2550
Query 2555 SDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAA 2614
+ VGDS+E++ KMFD++V++F + ++V +KL+ L++TA + +G VL+TF+ AA
Sbjct 2551 TSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAA 2610
Query 2615 RQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNA 2673
R V++DV+T ++++ ++ +H D+++T +S NN++ +Y K ++++ DLG+ IDCNA
Sbjct 2611 RGPAGVESDVETNEIVDSVQYAHKHDIQITNESYNNYVPSYVKPDSVSTSDLGSLIDCNA 2670
Query 2674 RHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITT 2733
+N V ++ N + IWN YM LS+ L++QIR A +K N+ FRLT + R N+++
Sbjct 2671 ASVNQIVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSV 2730
Query 2734 KISLKG---------GKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEII 2784
+ + + K + AT++ L A++ Y+ +P ++ + Y + I+
Sbjct 2731 RFTANKIVGGAPTWFNALRDFTLKGYVLATIIVFLCAVLMYLCLPTFSMVPVEFYEDRIL 2790
Query 2785 GYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKSCPVVAAIITREIGFIV 2843
+K + +G+ RD+ D CFANKH F W+ + GG Y N +CP+ A+I G +
Sbjct 2791 DFKVLDNGIIRDVNPDDKCFANKHRSFTQWYHEHVGGVYDNSITCPLTVAVIAGVAGARI 2850
Query 2844 PGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAM 2903
P +P T L +N + F+ RVF+ G++CYTP I Y F+ S C+L +ECT+F+DA
Sbjct 2851 PDVPTT-LAWVNNQIIFFVSRVFANTGSVCYTPIDEIPYKSFSDSGCILPSECTMFRDAE 2909
Query 2904 GKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNTYLEGSVRVVTTFDAEYCR 2962
G+ PYC+D +L G+ +YS++RP RY L DG++ I+FP E ++R+ T +YCR
Sbjct 2910 GRMTPYCHDPTVLPGAFAYSQMRPHVRYDLYDGNMFIKFPEVVFESTLRITRTLSTQYCR 2969
Query 2963 HGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSA 3022
G+CE ++ G+C++T+G W + N+H+ GV+CG D ++++ + L QP+ ++
Sbjct 2970 FGSCEYAQEGVCITTNGSWAIFNDHHLNRPGVYCGSDFIDIVRRLAVSLFQPITYFQLTT 3029
Query 3023 SVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVY 3082
S+V G + +T YY K +R F +Y + +++ +C V + Y
Sbjct 3030 SLVLGIGLCAFLTLLFYYINKVKRAFADYTQCAVIAVVAAVLNSLCICFVASIPLCIVPY 3089
Query 3083 SVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV 3142
+ Y Y TFYFTN+ +F+ H+ W+ MF PIVP W+T +Y + +H W + +K V
Sbjct 3090 TALYYYATFYFTNEPAFIMHVSWYIMFGPIVPIWMTCVYTVAMCFRHFFWVLAYFSKKHV 3149
Query 3143 --MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDT 3200
+G +F++AA F++NK+ Y LR+ L Y+R+L L+NKYKYFSGA++T
Sbjct 3150 EVFTDGKLNCSFQDAASNIFVINKDTYAALRNS--LTNDAYSRFLGLFNKYKYFSGAMET 3207
Query 3201 TSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQV 3260
+YREAA CHLAKAL +S +G+D+LYQPP SITS VLQSG KM+ PSG VE CMVQV
Sbjct 3208 AAYREAAACHLAKALQTYSETGSDLLYQPPNCSITSGVLQSGLVKMSHPSGDVEACMVQV 3267
Query 3261 TCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRV 3317
TCG+ TLNGLWLD+TV+CPRHV+C A+ + +PNY+ LLI +NHSF VQ LRV
Sbjct 3268 TCGSMTLNGLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRV 3327
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+GH+MQ LL+L VD +NP TP Y F ++PG FSVLACYNG P+G + MRPN+TIK
Sbjct 3328 VGHAMQGTLLKLTVDVANPSTPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIK 3387
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSFL GSCGSVG+ + ++FCYMH MEL G H G+ +G YG F+D+Q Q TD
Sbjct 3388 GSFLCGSCGSVGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTD 3447
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
++NV+AWLYAA++NG WF+ T++ FN A+ + + L+ +T
Sbjct 3448 KYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVG--TQSVDMLAVKT 3505
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTH 3557
G+A+ + A+++L G G+ ILGST+LEDEFTP DV Q GV Q +K+ GT
Sbjct 3506 GVAIEQLLYAIQQLY-TGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQSGVRKVTYGTA 3564
Query 3558 HWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFL 3617
HW+ T +++ +I++Q+T+++L+ +++E + A MLLVKHKH FL LFL
Sbjct 3565 HWLFATLVSTYVIILQATKFTLWNYLFETIPTQLFPLLFVTMAFVMLLVKHKHTFLTLFL 3624
Query 3618 LPSLATVAYFNMVYMP----ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMT 3673
LP + Y N+VY P +S ++ + WL + + D +Y S ++L+++
Sbjct 3625 LPVAICLTYANIVYEPTTPISSALIAVANWLAPTNAYMRTTH-TDIGVYISMSLVLVIVV 3683
Query 3674 ARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLAR 3733
R + L + + +Y G A I+ V ++TS+Y+ V + LA+
Sbjct 3684 KRLYNPSLSNFALALCSGVMWLYTYSIGEA-SSPIAYLVFVTTLTSDYTITVFVTVNLAK 3742
Query 3734 AIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
+ Y P L + ++ I+L+Y LG+ C CYFG+F LLN R +GVYD+ VS
Sbjct 3743 VCTYAIFAYSPQLTLVFPEVKMILLLYTCLGFMCTCYFGVFSLLNLKLRAPMGVYDFKVS 3802
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
TQEFR+M + L P++S +A LN KL+GIGG PCIKVA +QSK++D+KCTSVVLLSVL
Sbjct 3803 TQEFRFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQSKLTDLKCTSVVLLSVL 3862
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLD 3913
QQL +E++S+ WA CV+ HNDIL A D +EAFEK VSL + L++ G VD++ L ++ D
Sbjct 3863 QQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFD 3922
Query 3914 NRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDA 3972
+ LQA SEFS L ++A AQ+AY++A+ +GD S VLK L+K++N+AK+ +++D
Sbjct 3923 TPSVLQATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDK 3982
Query 3973 AMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDG 4032
A+ RKLE+MADQAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN II+NAR+G
Sbjct 3983 AVARKLERMADQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGIISNARNG 4042
Query 4033 CVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEIN 4092
C+PL++IPL + KL VV+PD+ + + YA ALW+I + + D++IV+ S++
Sbjct 4043 CIPLSVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDV- 4101
Query 4093 MDNSPNLAWPLIVTALRAN-SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNN 4151
+D++ NL WPL++ RA+ SAVKLQNNE+ P L+ M +AG QT C + ++LAYY
Sbjct 4102 VDSNENLTWPLVLECTRASTSAVKLQNNEIKPSGLKTMVVSAGQEQTNC-NTSSLAYYEP 4160
Query 4152 SKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGL 4211
+G + ++ALLSD+ LKWAR DG ++ EL+PPC+F+ PKGP+++YLYF+K L
Sbjct 4161 VQGRKMLMALLSDNAYLKWARVEGKDGFVSV--ELQPPCKFLIAGPKGPEIRYLYFVKNL 4218
Query 4212 NNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNC 4271
NNL+RG VLG +AATVRLQAG+ TE +NS+VLS F VDP KAY D++ +GG P+TNC
Sbjct 4219 NNLHRGQVLGHIAATVRLQAGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNC 4278
Query 4272 VKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPT 4331
VKML TGTG AI+V PE+ DQE++GGAS CLYCR HI+HP+ G C KGK+VQIP
Sbjct 4279 VKMLTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPA 4338
Query 4332 TCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
C DPVGF L NT C VC W GYGC+CD LR+ + + S FLN V
Sbjct 4339 QCVRDPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQSKDSNFLNESGV 4389
Score = 969 bits (2505), Expect = 0.0, Method: Composition-based stats.
Identities = 328/1346 (24%), Positives = 558/1346 (41%), Gaps = 178/1346 (13%)
Query 13 HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLKNGTCGL-VEL-EKGVLPQLEQP 67
HV L++P+ ++ L F D E A + L L V + G L P
Sbjct 28 HVSLTVPLCGSGNLVEKLSPWFMDG-ENAYEVVKAMLLKKEPLLYVPIRLAGHTRHLPGP 86
Query 68 YVFIKRSDALSTNHGHKVVELVAEM---DGIQYGRS--GITLGVLVPHVGETPIAYRNVL 122
V++ N +V +A +G G + G +G+ P+ E +N+L
Sbjct 87 RVYLVERLIACEN--PFMVNQLAYSSSANGSLVGTTLQGKPIGMFFPYDIELVTGKQNIL 144
Query 123 LRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAV 182
LRK G G Y Y+ + + ++D+E + K+ L ++L GG V
Sbjct 145 LRKYGRGG-----YHYTPFHYERDNTSCPEWMDDFEADPKGKYAQN----LLKKLIGGDV 195
Query 183 TRYVDNNFCGPDGYPLDCIKDFLARAG-KSMCTLSEQLDYIESKRGVYCCRDHEHEIAWF 241
T VD CG DG P+ +A+ G + + + G +++ + + W
Sbjct 196 TP-VDQYMCGVDGKPISAYAFLMAKDGITKLADVEADVAARADDEGFITLKNNLYRLVWH 254
Query 242 TERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIR 301
ER D Y Q+ F I S + D + P F L K+ + PR + + +
Sbjct 255 VERKDVPYPKQSIFTINSVVQKDGVENTPP-HYFTLGCKILTLTPRNKWSGVSDLSLKQK 313
Query 302 SVYPVASPQE---CNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGP-TTC 357
+Y + ++ S ++C C SW T + ++ CG + +
Sbjct 314 LLYTFYGKESLENPTYIYHSAFIECGSCGNDSWLTGNAIQGFACGCGASYTANDVEVQSS 373
Query 358 GYLPTNAVVKMPCPACQDPEIGP--EHSVADYHNHSNIETRLRKGGR--TRCFGGCVFAY 413
G + NA++ CP + +HSVA ++ + + + T FGG +AY
Sbjct 374 GMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSERCNVIADSKSFTLIFGGVAYAY 433
Query 414 VGCYNKRAYWVPRASAD-------IGSGHTGITGDNVETLNEDLLEILSRERVNINIVGD 466
GC Y+VPRA + I +G TG + N L + + ++N VG+
Sbjct 434 FGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQIAN----MFLEQTQHSLNFVGE 489
Query 467 FHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIG-- 524
F +N+ V IL+ + + +K + + + + VT G + A N+G
Sbjct 490 FVVNDVVLAILSGTTTNVDKIRQLLKGVTLDKLRDYLADY-DVAVTAGPFMDNAINVGGT 548
Query 525 --QQRSVLTP---LCGFPSQAAGV------IRSIFARTLDAANHSIPDLQRAAVTILD-G 572
Q ++ P L G V + + TL HS+ L R +D G
Sbjct 549 GLQYAAITAPYVVLTGLGESFKKVATIPYKVCNSVKDTLTYYAHSV--LYRVFPYDMDSG 606
Query 573 ISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIE 632
+S S L D + SV ++ L +T ++S ++ + + + +
Sbjct 607 VSSFSELLFDC-------VDLSVASTYFLVRLLQDKTGDFMSTIITSCQTAVSKLLDTCF 659
Query 633 AKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQ 692
A FL D + + + + V + + VK +D++NK +++ +
Sbjct 660 EATEATFNFLLDLAGLFRIFLRNAYVYTSQGFVVVNGKVSTLVKQVLDLLNKGMQLLHTK 719
Query 693 VTIAGAKLRSLNLG--EVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEVTFLEGDS 746
V+ AG+ + ++ E I S Y + K + L +++P + + K++ L+
Sbjct 720 VSWAGSNISAVIYSGRESLIFPSGTYYCVTTKAKSVQQDLDVILPGEFSKKQLGLLQPTD 779
Query 747 HDTVLTSEE----VVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKE---QY 799
+ T ++ V G+LE + + IVG V ++ + + K+++ Y
Sbjct 780 NSTTVSVTVSSNMVETVVGQLEQ----TNMHSPDVIVGDYVIISEKLFVRSKEEDGFAFY 835
Query 800 CALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL-NEKC 858
A + G A +FRLKGGAP+K V FG D V EV ++V + + + +D +L +
Sbjct 836 PACTNGH-AVPTLFRLKGGAPVKKVAFGGDQVHEVAAVRSVTVEYNIHAVLDTLLASSSL 894
Query 859 SVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFS 918
+ V+ + EFA VV E V L + + DLD++ A Y F+ G+ ++S
Sbjct 895 RTFVVDKSLSIEEFADVVKEQVSDLLVKLLRGMPIPDFDLDDFIDAPCYCFNAEGDASWS 954
Query 919 SRMYCSFYPPD-----------EEEEDDAECEEEEIDETCEHEYGTEDDY------QGLP 961
S M S +P + + EE ++EC E E + + DD + P
Sbjct 955 STMIFSLHPVECDEECSEVEASDLEEGESECISETSTEQVDVSHEISDDEWAAAVDEAFP 1014
Query 962 LEFGASAETVRVEEEEEE--------------DWLDDTT---EQSEIEPEPEPTPEEP-- 1002
L+ A T V+EE + D L +T + E+ P+ P EP
Sbjct 1015 LD-EAEDVTESVQEEAQPVEVPVEDIAQVVIADTLQETPVVSDTVEVPPQVVKLPSEPQT 1073
Query 1003 ----------------------------------VNQFTGYLK--LTDNVAIKCVDIVKE 1026
V+ + + +T+ V I D ++
Sbjct 1074 IQPEVKEVAPVYEADTEQTQSVTVKPKRLRKKRNVDPLSNFEHKVITECVTIVLGDAIQV 1133
Query 1027 AQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGH 1086
A+ V+VNAAN HLKHGGG+AGA+N A+ GA+QKESD+YI GPL VG S LL GH
Sbjct 1134 AKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGH 1193
Query 1087 NLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQT 1146
+LAK LHVVGP+ A +D+ LL Y+ N+ +++ PL+SAGIFG KP S ++
Sbjct 1194 SLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIRE 1253
Query 1147 VRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKP 1206
+T+V + VN + +Y+ + + V+ P + + D + ++K D
Sbjct 1254 AKTRVLVVVNSQDVYKSLTI---------VDIP--QSLTFSYDGL---RGAIRKAKDYGF 1299
Query 1207 KIKACIDEVTTTLEETKFLTNKLLLF 1232
+ C D TK L NK + +
Sbjct 1300 TVFVCTD----NSANTKVLRNKGVDY 1321
>sp|K9N7C7|R1AB_MERS1 Replicase polyprotein 1ab OS=Middle East
respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)
OX=1263720 GN=rep PE=1 SV=1
Length=7078
Score = 3729 bits (9669), Expect = 0.0, Method: Composition-based stats.
Identities = 1241/3406 (36%), Positives = 1888/3406 (55%), Gaps = 194/3406 (6%)
Query 1109 LKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVY----IAVNDKALYEQV 1164
++ + + + P++S + + L QT++ +V + D + V
Sbjct 1036 VEDIAQVVIADTLQETPVVSDTVEVPPQVVKLPSEPQTIQPEVKEVAPVYEADTEQTQSV 1095
Query 1165 VMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKF 1224
+ R+ + +P + + K + V D K + V T
Sbjct 1096 TVK-----PKRLRKKRNVDPLSNFEHKVITECVTIVLGDAIQVAKCYGESVLVNAANTHL 1150
Query 1225 LTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITS------GDITCVVIP 1278
I G + S+ ++ E ++ P VGD + +I VV P
Sbjct 1151 KHG-----GGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGHSLAKNILHVVGP 1205
Query 1279 SKKAGGTTEMLSRALKK---VPVDEYITTYPGQGCAG--------YTLEEAKTALKKCKS 1327
+A +LS+ K P+ +T G G Y + EAKT + +
Sbjct 1206 DARAKQDVSLLSKCYKAMNAYPL--VVTPLVSAGIFGVKPAVSFDYLIREAKTRVLVVVN 1263
Query 1328 AFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKI 1387
+ V S + L LR + A++ + +C D A ++ K
Sbjct 1264 SQDVYKSLTIVDIPQSLTFSYDGLRGAIRKAKDYGFTVFVCTDNSANTKVLRNKGVDYTK 1323
Query 1388 QEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKA 1447
+ VD GV+++ YTSK+ + I+ + N + +++MP+GYV+HG +L +A +R +
Sbjct 1324 KFLTVD-GVQYYCYTSKDTLDDILQQANK-SVGIISMPLGYVSHGLDLIQAGSVVRRVNV 1381
Query 1448 PAVVSVSSPDAVTTYNGYLTSSSK--TSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLK 1505
P V +++ + L S E F++ V G Y W EL V+ L+
Sbjct 1382 PYVCLLANKEQ----EAILMSEDVKLNPSEDFIKHVRTNGGYNSWHLV--EGELLVQDLR 1435
Query 1506 RGDKI------------VYHTLESPVEFHLDGEVLSLDKLKSLLSLREVK--TIKVFTTV 1551
+ V++ +++ F + +L ++ L R + TI+V TV
Sbjct 1436 LNKLLHWSDQTICYKDSVFYVVKNSTAFPFE----TLSACRAYLDSRTTQQLTIEVLVTV 1491
Query 1552 DNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAF-E 1610
D N T +++ TY Q G + +GAD++ P G + ++ + ++A E
Sbjct 1492 DGVNFRTVVLNNKNTYRSQLGCVFFNGADISDTIPDEKQNGHSLYLADNLTADETKALKE 1551
Query 1611 YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLE-VKFNA 1669
Y +D +FL R+ S KWK + S+K +DNNCYL++V++ L L+ +KF
Sbjct 1552 LYGPVDPTFLHRFYSLKAAVHKWKMVVCDKVRSLKLSDNNCYLNAVIMTLDLLKDIKFVI 1611
Query 1670 PALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLE-SAKRVLNVV 1728
PALQ A+ + + GD+ +F ALI+AY N T G D + +L A L SA+ V
Sbjct 1612 PALQHAFMKHKGGDSTDFIALIMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREW 1671
Query 1729 CKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPP 1788
C CG K L G++A Y+G + ++L+ ++ C CG + + +V+ + ++++S P
Sbjct 1672 CNVCGIKDVVLQGLKACCYVGVQTVEDLRARMTYVCQCGGERHRQIVEHTTPWLLLSGTP 1731
Query 1789 AEYKLQQGT---FLCANEYTG-NYQCGHYTHITAKETL-YRIDGAHLTKMSEYKGPVTDV 1843
E + T F+ N + G GHY H K L + D ++K S++K VTDV
Sbjct 1732 NEKLVTTSTAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTSDWKCKVTDV 1791
Query 1844 FYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYT-EQPIDLVPTQPLPNASF 1902
+ Y++ V Y LDG TE++P L +Y KD Y+T E P+ P L + +
Sbjct 1792 LFPGQKYSSDCNVVRYSLDGNFRTEVDPDLSAFYVKDGKYFTSEPPVTYSPATILAGSVY 1851
Query 1903 DNFKLTCSNTKFADD-----LNQMTGF--TKPASRELSVTFFPDLNGDVVAIDYRHYSAS 1955
N L S+ + D N + GF +KP +++ + +F P +GDV+ ++ Y
Sbjct 1852 TNSCLVSSDGQPGGDAISLSFNNLLGFDSSKPVTKKYTYSFLPKEDGDVLLAEFDTYDPI 1911
Query 1956 FKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDN 2015
+K GA KPI+W + K N LR ++ P++ N F L+VE T
Sbjct 1912 YKNGAMYKGKPILWVNKASYDTNLNKFNRASLRQIFDVAPIELENKFTPLSVEST----- 1966
Query 2016 LACESQQPTSEEVVENPTIQKE--VIECD-VKTTEVVGNVILKPSDEGVKVTQELGHEDL 2072
P V+ +Q+E +++C + V NV D G V + L EDL
Sbjct 1967 -------PVEPPTVDVVALQQEMTIVKCKGLNKPFVKDNVSFVADDSGTPVVEYLSKEDL 2019
Query 2073 MAAYVE-NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAI--- 2128
YV+ + + K N LS L L T+ + IN V S L L +A+
Sbjct 2020 HTLYVDPKYQVIVLKDNVLSSMLRLHTVES---GDINVVAASGSLTRKVKLLFRASFYFK 2076
Query 2129 -----------TTSNCAKRLAQRV---------FNNYMPYVFTLLFQLCTFTKSTNSRIR 2168
+C K + + + +++ +F L + +K + ++
Sbjct 2077 EFATRTFTATTAVGSCIKSVVRHLGVTKGILTGCFSFVKMLFMLPLAYFSDSKLGTTEVK 2136
Query 2169 ASLPTT---IAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTA 2225
S T + N VK +D ++ ++ + + + L + L S+ +
Sbjct 2137 VSALKTAGVVTGNVVKQCCTAAVDLSMDKLRRVDWKSTLRLLLMLCTTMVLLSSVYHLYV 2196
Query 2226 AFGVLLSN-------------------FGAPSYCNGVRELY-LNSSNVTTMDFCEG-SFP 2264
VL S+ G S C+G+ Y NS +V T FC S
Sbjct 2197 FNQVLSSDVMFEDAQGLKKFYKEVRAYLGISSACDGLASAYRANSFDVPT--FCANRSAM 2254
Query 2265 CSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIM 2324
C+ CL DS+ YPAL+ +Q +S Y L++ L A E LAYML+T F L L+ +
Sbjct 2255 CNWCLISQDSITHYPALKMVQTHLSHYVLNIDWLWFAFETGLAYMLYTSAFNWLLLAGTL 2314
Query 2325 QVFFGY------FASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIM 2378
FF + S+ + S W I P++ +VRMY A + + K Y H++
Sbjct 2315 HYFFAQTSIFVDWRSYNYAVSSAFWLFTHI----PMAGLVRMYNLLACLWLLRKFYQHVI 2370
Query 2379 DGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTG 2438
+GC + C++CYKRNR TRVE +T+V G KR+FY+ ANGG FC+ HNWNC++CDT G
Sbjct 2371 NGCKDTACLLCYKRNRLTRVEASTVVCGGKRTFYITANGGISFCRRHNWNCVDCDTAGVG 2430
Query 2439 STFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHF 2498
+TFI +EVA DL+ +RPIN TD+S Y VDSV VK + + + GQ YER PL F
Sbjct 2431 NTFICEEVANDLTTALRRPINATDRSHYYVDSVTVKETVVQFNYRRDGQPFYERFPLCAF 2490
Query 2499 VNLDNLR----ANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALV 2554
NLD L+ T G N I++D + ES ++SA VYYSQ++C+ ILL+D +LV
Sbjct 2491 TNLDKLKFKEVCKTTTGIPEYNFIIYDSSDRGQESLARSACVYYSQVLCKSILLVDSSLV 2550
Query 2555 SDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAA 2614
+ VGDS+E++ KMFD++V++F + ++V +KL+ L++TA + +G VL+TF+ AA
Sbjct 2551 TSVGDSSEIATKMFDSFVNSFVSLYNVTRDKLEKLISTARDGVRRGDNFHSVLTTFIDAA 2610
Query 2615 RQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNA 2673
R V++DV+T ++++ ++ +H D+++T +S NN++ +Y K ++++ DLG+ IDCNA
Sbjct 2611 RGPAGVESDVETNEIVDSVQYAHKHDIQITNESYNNYVPSYVKPDSVSTSDLGSLIDCNA 2670
Query 2674 RHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITT 2733
+N V ++ N + IWN YM LS+ L++QIR A +K N+ FRLT + R N+++
Sbjct 2671 ASVNQIVLRNSNGACIWNAAAYMKLSDALKRQIRIACRKCNLAFRLTTSKLRANDNILSV 2730
Query 2734 KISLKG---------GKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEII 2784
+ + + K + AT++ L A++ Y+ +P ++ + Y + I+
Sbjct 2731 RFTANKIVGGAPTWFNALRDFTLKGYVLATIIVFLCAVLMYLCLPTFSMVPVEFYEDRIL 2790
Query 2785 GYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQR-GGSYKNDKSCPVVAAIITREIGFIV 2843
+K + +G+ RD+ D CFANKH F W+ + GG Y N +CP+ A+I G +
Sbjct 2791 DFKVLDNGIIRDVNPDDKCFANKHRSFTQWYHEHVGGVYDNSITCPLTVAVIAGVAGARI 2850
Query 2844 PGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAM 2903
P +P T L +N + F+ RVF+ G++CYTP I Y F+ S C+L +ECT+F+DA
Sbjct 2851 PDVPTT-LAWVNNQIIFFVSRVFANTGSVCYTPIDEIPYKSFSDSGCILPSECTMFRDAE 2909
Query 2904 GKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSI-IQFPNTYLEGSVRVVTTFDAEYCR 2962
G+ PYC+D +L G+ +YS++RP RY L DG++ I+FP E ++R+ T +YCR
Sbjct 2910 GRMTPYCHDPTVLPGAFAYSQMRPHVRYDLYDGNMFIKFPEVVFESTLRITRTLSTQYCR 2969
Query 2963 HGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSA 3022
G+CE ++ G+C++T+G W + N+H+ GV+CG D ++++ + L QP+ ++
Sbjct 2970 FGSCEYAQEGVCITTNGSWAIFNDHHLNRPGVYCGSDFIDIVRRLAVSLFQPITYFQLTT 3029
Query 3023 SVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVY 3082
S+V G + +T YY K +R F +Y + +++ +C V + Y
Sbjct 3030 SLVLGIGLCAFLTLLFYYINKVKRAFADYTQCAVIAVVAAVLNSLCICFVASIPLCIVPY 3089
Query 3083 SVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRV 3142
+ Y Y TFYFTN+ +F+ H+ W+ MF PIVP W+T +Y + +H W + +K V
Sbjct 3090 TALYYYATFYFTNEPAFIMHVSWYIMFGPIVPIWMTCVYTVAMCFRHFFWVLAYFSKKHV 3149
Query 3143 --MFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDT 3200
+G +F++AA F++NK+ Y LR+ L Y+R+L L+NKYKYFSGA++T
Sbjct 3150 EVFTDGKLNCSFQDAASNIFVINKDTYAALRNS--LTNDAYSRFLGLFNKYKYFSGAMET 3207
Query 3201 TSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQV 3260
+YREAA CHLAKAL +S +G+D+LYQPP SITS VLQSG KM+ PSG VE CMVQV
Sbjct 3208 AAYREAAACHLAKALQTYSETGSDLLYQPPNCSITSGVLQSGLVKMSHPSGDVEACMVQV 3267
Query 3261 TCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQ---AGNVQLRV 3317
TCG+ TLNGLWLD+TV+CPRHV+C A+ + +PNY+ LLI +NHSF VQ LRV
Sbjct 3268 TCGSMTLNGLWLDNTVWCPRHVMCPADQLSDPNYDALLISMTNHSFSVQKHIGAPANLRV 3327
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+GH+MQ LL+L VD +NP TP Y F ++PG FSVLACYNG P+G + MRPN+TIK
Sbjct 3328 VGHAMQGTLLKLTVDVANPSTPAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIK 3387
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSFL GSCGSVG+ + ++FCYMH MEL G H G+ +G YG F+D+Q Q TD
Sbjct 3388 GSFLCGSCGSVGYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTD 3447
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
++NV+AWLYAA++NG WF+ T++ FN A+ + + L+ +T
Sbjct 3448 KYCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVG--TQSVDMLAVKT 3505
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTH 3557
G+A+ + A+++L G G+ ILGST+LEDEFTP DV Q GV Q +K+ GT
Sbjct 3506 GVAIEQLLYAIQQLY-TGFQGKQILGSTMLEDEFTPEDVNMQIMGVVMQSGVRKVTYGTA 3564
Query 3558 HWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFL 3617
HW+ T +++ +I++Q+T+++L+ +++E + A MLLVKHKH FL LFL
Sbjct 3565 HWLFATLVSTYVIILQATKFTLWNYLFETIPTQLFPLLFVTMAFVMLLVKHKHTFLTLFL 3624
Query 3618 LPSLATVAYFNMVYMP----ASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMT 3673
LP + Y N+VY P +S ++ + WL + + D +Y S ++L+++
Sbjct 3625 LPVAICLTYANIVYEPTTPISSALIAVANWLAPTNAYMRTTH-TDIGVYISMSLVLVIVV 3683
Query 3674 ARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLAR 3733
R + L + + +Y G A I+ V ++TS+Y+ V + LA+
Sbjct 3684 KRLYNPSLSNFALALCSGVMWLYTYSIGEA-SSPIAYLVFVTTLTSDYTITVFVTVNLAK 3742
Query 3734 AIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVS 3793
+ Y P L + ++ I+L+Y LG+ C CYFG+F LLN R +GVYD+ VS
Sbjct 3743 VCTYAIFAYSPQLTLVFPEVKMILLLYTCLGFMCTCYFGVFSLLNLKLRAPMGVYDFKVS 3802
Query 3794 TQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVL 3853
TQEFR+M + L P++S +A LN KL+GIGG PCIKVA +QSK++D+KCTSVVLLSVL
Sbjct 3803 TQEFRFMTANNLTAPRNSWEAMALNFKLIGIGGTPCIKVAAMQSKLTDLKCTSVVLLSVL 3862
Query 3854 QQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLD 3913
QQL +E++S+ WA CV+ HNDIL A D +EAFEK VSL + L++ G VD++ L ++ D
Sbjct 3863 QQLHLEANSRAWAFCVKCHNDILAATDPSEAFEKFVSLFATLMTFSGNVDLDALASDIFD 3922
Query 3914 NRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLNVAKSEFDRDA 3972
+ LQA SEFS L ++A AQ+AY++A+ +GD S VLK L+K++N+AK+ +++D
Sbjct 3923 TPSVLQATLSEFSHLATFAELEAAQKAYQEAMDSGDTSPQVLKALQKAVNIAKNAYEKDK 3982
Query 3973 AMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDG 4032
A+ RKLE+MADQAMT MYKQAR+EDK+AK+ SAMQTMLF M++KLDND LN II+NAR+G
Sbjct 3983 AVARKLERMADQAMTSMYKQARAEDKKAKIVSAMQTMLFGMIKKLDNDVLNGIISNARNG 4042
Query 4033 CVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEIN 4092
C+PL++IPL + KL VV+PD+ + + YA ALW+I + + D++IV+ S++
Sbjct 4043 CIPLSVIPLCASNKLRVVIPDFTVWNQVVTYPSLNYAGALWDITVINNVDNEIVKSSDV- 4101
Query 4093 MDNSPNLAWPLIVTALRAN-SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNN 4151
+D++ NL WPL++ RA+ SAVKLQNNE+ P L+ M +AG QT C + ++LAYY
Sbjct 4102 VDSNENLTWPLVLECTRASTSAVKLQNNEIKPSGLKTMVVSAGQEQTNC-NTSSLAYYEP 4160
Query 4152 SKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGL 4211
+G + ++ALLSD+ LKWAR DG ++ EL+PPC+F+ PKGP+++YLYF+K L
Sbjct 4161 VQGRKMLMALLSDNAYLKWARVEGKDGFVSV--ELQPPCKFLIAGPKGPEIRYLYFVKNL 4218
Query 4212 NNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNC 4271
NNL+RG VLG +AATVRLQAG+ TE +NS+VLS F VDP KAY D++ +GG P+TNC
Sbjct 4219 NNLHRGQVLGHIAATVRLQAGSNTEFASNSSVLSLVNFTVDPQKAYLDFVNAGGAPLTNC 4278
Query 4272 VKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPT 4331
VKML TGTG AI+V PE+ DQE++GGAS CLYCR HI+HP+ G C KGK+VQIP
Sbjct 4279 VKMLTPKTGTGIAISVKPESTADQETYGGASVCLYCRAHIEHPDVSGVCKYKGKFVQIPA 4338
Query 4332 TCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFL 4377
C DPVGF L NT C VC W GYGC+CD LR+ + + S FL
Sbjct 4339 QCVRDPVGFCLSNTPCNVCQYWIGYGCNCDSLRQAALPQSKDSNFL 4384
Score = 969 bits (2506), Expect = 0.0, Method: Composition-based stats.
Identities = 328/1346 (24%), Positives = 558/1346 (41%), Gaps = 178/1346 (13%)
Query 13 HVQLSLPVLQVRDV---LVRGFGDSVEEALSEAREHLKNGTCGL-VEL-EKGVLPQLEQP 67
HV L++P+ ++ L F D E A + L L V + G L P
Sbjct 28 HVSLTVPLCGSGNLVEKLSPWFMDG-ENAYEVVKAMLLKKEPLLYVPIRLAGHTRHLPGP 86
Query 68 YVFIKRSDALSTNHGHKVVELVAEM---DGIQYGRS--GITLGVLVPHVGETPIAYRNVL 122
V++ N +V +A +G G + G +G+ P+ E +N+L
Sbjct 87 RVYLVERLIACEN--PFMVNQLAYSSSANGSLVGTTLQGKPIGMFFPYDIELVTGKQNIL 144
Query 123 LRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAV 182
LRK G G Y Y+ + + ++D+E + K+ L ++L GG V
Sbjct 145 LRKYGRGG-----YHYTPFHYERDNTSCPEWMDDFEADPKGKYAQN----LLKKLIGGDV 195
Query 183 TRYVDNNFCGPDGYPLDCIKDFLARAG-KSMCTLSEQLDYIESKRGVYCCRDHEHEIAWF 241
T VD CG DG P+ +A+ G + + + G +++ + + W
Sbjct 196 TP-VDQYMCGVDGKPISAYAFLMAKDGITKLADVEADVAARADDEGFITLKNNLYRLVWH 254
Query 242 TERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIR 301
ER D Y Q+ F I S + D + P F L K+ + PR + + +
Sbjct 255 VERKDVPYPKQSIFTINSVVQKDGVENTPP-HYFTLGCKILTLTPRNKWSGVSDLSLKQK 313
Query 302 SVYPVASPQE---CNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGP-TTC 357
+Y + ++ S ++C C SW T + ++ CG + +
Sbjct 314 LLYTFYGKESLENPTYIYHSAFIECGSCGNDSWLTGNAIQGFACGCGASYTANDVEVQSS 373
Query 358 GYLPTNAVVKMPCPACQDPEIGP--EHSVADYHNHSNIETRLRKGGR--TRCFGGCVFAY 413
G + NA++ CP + +HSVA ++ + + + T FGG +AY
Sbjct 374 GMIKPNALLCATCPFAKGDSCSSNCKHSVAQLVSYLSERCNVIADSKSFTLIFGGVAYAY 433
Query 414 VGCYNKRAYWVPRASAD-------IGSGHTGITGDNVETLNEDLLEILSRERVNINIVGD 466
GC Y+VPRA + I +G TG + N L + + ++N VG+
Sbjct 434 FGCEEGTMYFVPRAKSVVSRIGDSIFTGCTGSWNKVTQIAN----MFLEQTQHSLNFVGE 489
Query 467 FHLNEEVAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIG-- 524
F +N+ V IL+ + + +K + + + + VT G + A N+G
Sbjct 490 FVVNDVVLAILSGTTTNVDKIRQLLKGVTLDKLRDYLADY-DVAVTAGPFMDNAINVGGT 548
Query 525 --QQRSVLTP---LCGFPSQAAGV------IRSIFARTLDAANHSIPDLQRAAVTILD-G 572
Q ++ P L G V + + TL HS+ L R +D G
Sbjct 549 GLQYAAITAPYVVLTGLGESFKKVATIPYKVCNSVKDTLTYYAHSV--LYRVFPYDMDSG 606
Query 573 ISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIE 632
+S S L D + SV ++ L +T ++S ++ + + + +
Sbjct 607 VSSFSELLFDC-------VDLSVASTYFLVRLLQDKTGDFMSTIITSCQTAVSKLLDTCF 659
Query 633 AKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQ 692
A FL D + + + + V + + VK +D++NK +++ +
Sbjct 660 EATEATFNFLLDLAGLFRIFLRNAYVYTSQGFVVVNGKVSTLVKQVLDLLNKGMQLLHTK 719
Query 693 VTIAGAKLRSLNLG--EVFIAQSKGLYRQCIRGK---EQLQLLMPLK-APKEVTFLEGDS 746
V+ AG+ + ++ E I S Y + K + L +++P + + K++ L+
Sbjct 720 VSWAGSNISAVIYSGRESLIFPSGTYYCVTTKAKSVQQDLDVILPGEFSKKQLGLLQPTD 779
Query 747 HDTVLTSEE----VVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKE---QY 799
+ T ++ V G+LE + + IVG V ++ + + K+++ Y
Sbjct 780 NSTTVSVTVSSNMVETVVGQLEQ----TNMHSPDVIVGDYVIISEKLFVRSKEEDGFAFY 835
Query 800 CALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVL-NEKC 858
A + G A +FRLKGGAP+K V FG D V EV ++V + + + +D +L +
Sbjct 836 PACTNGH-AVPTLFRLKGGAPVKKVAFGGDQVHEVAAVRSVTVEYNIHAVLDTLLASSSL 894
Query 859 SVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFS 918
+ V+ + EFA VV E V L + + DLD++ A Y F+ G+ ++S
Sbjct 895 RTFVVDKSLSIEEFADVVKEQVSDLLVKLLRGMPIPDFDLDDFIDAPCYCFNAEGDASWS 954
Query 919 SRMYCSFYPPD-----------EEEEDDAECEEEEIDETCEHEYGTEDDY------QGLP 961
S M S +P + + EE ++EC E E + + DD + P
Sbjct 955 STMIFSLHPVECDEECSEVEASDLEEGESECISETSTEQVDVSHEISDDEWAAAVDEAFP 1014
Query 962 LEFGASAETVRVEEEEEE--------------DWLDDTT---EQSEIEPEPEPTPEEP-- 1002
L+ A T V+EE + D L +T + E+ P+ P EP
Sbjct 1015 LD-EAEDVTESVQEEAQPVEVPVEDIAQVVIADTLQETPVVSDTVEVPPQVVKLPSEPQT 1073
Query 1003 ----------------------------------VNQFTGYLK--LTDNVAIKCVDIVKE 1026
V+ + + +T+ V I D ++
Sbjct 1074 IQPEVKEVAPVYEADTEQTQSVTVKPKRLRKKRNVDPLSNFEHKVITECVTIVLGDAIQV 1133
Query 1027 AQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGH 1086
A+ V+VNAAN HLKHGGG+AGA+N A+ GA+QKESD+YI GPL VG S LL GH
Sbjct 1134 AKCYGESVLVNAANTHLKHGGGIAGAINAASKGAVQKESDEYILAKGPLQVGDSVLLQGH 1193
Query 1087 NLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQT 1146
+LAK LHVVGP+ A +D+ LL Y+ N+ +++ PL+SAGIFG KP S ++
Sbjct 1194 SLAKNILHVVGPDARAKQDVSLLSKCYKAMNAYPLVVTPLVSAGIFGVKPAVSFDYLIRE 1253
Query 1147 VRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKP 1206
+T+V + VN + +Y+ + + V+ P + + D + ++K D
Sbjct 1254 AKTRVLVVVNSQDVYKSLTI---------VDIP--QSLTFSYDGL---RGAIRKAKDYGF 1299
Query 1207 KIKACIDEVTTTLEETKFLTNKLLLF 1232
+ C D TK L NK + +
Sbjct 1300 TVFVCTD----NSANTKVLRNKGVDY 1321
>sp|P0C6V0|R1A_CVMA5 Replicase polyprotein 1a OS=Murine coronavirus
(strain A59) OX=11142 GN=1a PE=1 SV=1
Length=4468
Score = 3648 bits (9459), Expect = 0.0, Method: Composition-based stats.
Identities = 1087/2923 (37%), Positives = 1604/2923 (55%), Gaps = 118/2923 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+ S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1596 KEASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1651
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
++GK FF A + DE L +Y + L KW G + K
Sbjct 1652 CSAIYKGKVFFQYSDLSEADLVAVKDAFGFDEPQLLKYYTMLGMC-KWPVVVCGNYFAFK 1710
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF QEA+ R+G F +L+LA + E D
Sbjct 1711 QSNNNCYINVACLMLQHLSLKFPKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1770
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ M +L+ A+L A L VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1771 IDFMRVVLREADLSGATCNLEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLVRGYNIACT 1829
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1830 CGSKLV-HCTQFNVPFLICSNTPEGRKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLY 1886
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D ++ K+SE KG TD Y K T + ++ LD V E +P L YY + YY
Sbjct 1887 DACNVNKVSEAKGNFTDCLYLKNLKQTFSSVLTTFYLDDVKCVEYKPDLSQYYCESGKYY 1946
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + + NFKL A+ LN GF E +T +P G
Sbjct 1947 TKPIIKAQFRTFEKVDGVYTNFKLV--GHSIAEKLNAKLGFDCNSPFVEYKITEWPTATG 2004
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP+VW ++ + + +P+ C ++ PVD
Sbjct 2005 DVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2063
Query 1999 SNSFE------VLAVEDTQGMD----------NLACES---QQPTSEEVVENPTI----Q 2035
S + + V G D AC S + EV + P++
Sbjct 2064 SEPTDKGPVPAAVLVTGVPGADASAGAGIAKEQKACASASVEDQVVTEVRQEPSVSAADV 2123
Query 2036 KEVIECDVKTT-EVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLAL 2094
KEV VK +V G+V++ KV + L D+ ++ + NELS +
Sbjct 2124 KEVKLNGVKKPVKVEGSVVVNDPTSETKVVKSLSIVDVYDMFLTGCKYVVWTANELSRLV 2183
Query 2095 GLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLF 2154
T+ + + KI+ K L + K + + Y + LL+
Sbjct 2184 NSPTVREYVKWGMG-----KIVTPAKLLLLRDEKQEFVAPKVVKAKAIACYCAVKWFLLY 2238
Query 2155 QLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLS 2214
+T++++ T +A K KLC A N +++ +S + + +
Sbjct 2239 CFSWIKFNTDNKVI--YTTEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLVATVF 2293
Query 2215 ICLGSLICVTAAFG-VLLSNFGA-PSYCNGVRELYLNSSNVTTM-------------DFC 2259
+ + + L N G P++ + + + V+T+ FC
Sbjct 2294 LLWFNFLYANVILSDFYLPNIGPLPTFVGQIVAWFKTTFGVSTICDFYQVTDLGYRSSFC 2353
Query 2260 EGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYMLFTKFFYL 2317
GS C +C SG D LD+Y A+ +Q + +++ L E V+ Y L+T FY
Sbjct 2354 NGSMVCELCFSGFDMLDNYDAINVVQHVVDRRLSFDYISLFKLVVELVIGYSLYTVCFYP 2413
Query 2318 LGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYV 2375
L + MQ+ + F+ + W + + M P ++R YI + Y ++
Sbjct 2414 LFVLIGMQLLTTWLPEFFMLETMHWSARLFVFVANMLPAFTLLRFYIVVTAMYKVYCLCR 2473
Query 2376 HIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTF 2435
H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNCLNC+++
Sbjct 2474 HVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQWNCLNCNSW 2533
Query 2436 CTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPL 2495
G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ+ Y+
Sbjct 2534 KPGNTFITHEAAADLSKELKRPVNPTDSAYYSVTEVKQVGCSMRLFYERDGQRVYDDVNA 2593
Query 2496 SHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
S FV+++ L + KG +V+V + ++ D++ A+V+Y+Q + +P+L++++ L++
Sbjct 2594 SLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLGAAVFYAQSLYRPMLMVEKKLIT 2651
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VS MFD YVD+ V + L + V AH+ L +GV L+ V+ TF+ AR
Sbjct 2652 TANTGLSVSRTMFDLYVDSLLNVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDTFIGCAR 2711
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG I NA+
Sbjct 2712 RKCAIDSDVETKSITKSVMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVLIQNNAK 2771
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V ++TT
Sbjct 2772 HVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANVPILTTP 2831
Query 2735 ISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVT 2794
SLKGG + S + + A L+C + V + +MP + + D +K I +GV
Sbjct 2832 FSLKGGAVFSRMLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASFKVIDNGVL 2888
Query 2795 RDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG + +P TVLR
Sbjct 2889 RDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVIDQDIGHTLFNVPTTVLR 2948
Query 2853 AINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD 2912
LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P PYCY
Sbjct 2949 -YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTPHPYCYT 3007
Query 2913 TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEV 2971
++ + YS L P RY L + I+FP EG VRVV T YCR G CE +E
Sbjct 3008 GGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRVGLCEEAEE 3067
Query 2972 GICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIA 3031
GIC + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS VAG I+A
Sbjct 3068 GICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSVAGAILA 3127
Query 3032 ILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTF 3091
I+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ FY Y T
Sbjct 3128 IIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACFYFYTTL 3187
Query 3092 YFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFST 3151
YF +++S + HLQW M+ I+P W IYV + H W F+ +++ + T
Sbjct 3188 YFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFSYC--RKIGTEVRSDGT 3245
Query 3152 FEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHL 3211
FEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +YREAAC L
Sbjct 3246 FEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQL 3303
Query 3212 AKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
AKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT G TLNGL
Sbjct 3304 AKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCIVSVTYGNMTLNGL 3363
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V +G + L V+ + MQ C L L
Sbjct 3364 WLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSGRMSLTVMSYQMQGCQLVLT 3423
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
V NP TPKY F ++PG+TF+VLA YNG P G + +R +HTIKGSFL GSCGSVG+
Sbjct 3424 VTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVTLRSSHTIKGSFLCGSCGSVGY 3483
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
+ D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+NV+AWLYA
Sbjct 3484 VLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTVNVVAWLYA 3543
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
A+ N WF+ + +L +FN+ AM + + D V L L++ TG+ V + AA+K
Sbjct 3544 AIFNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVEQVLAAIKR 3601
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L + I
Sbjct 3602 L-HSGFQGKQILGSCVLEDE-TPSDVYQQLAGVKLQSKRTRVIKGTCCWILASTFLFCSI 3659
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
+ +W++F +V + L TL + + AMLL+KHKH +L ++++P L T +V
Sbjct 3660 ISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLIKHKHLYLTMYIMPVLCTFYTNYLV 3718
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYDDAARRVWTLM 3689
S+ WL ++ Y D V+Y L++ ++ +T R++ D ++ +
Sbjct 3719 VYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHDVFSIMFLVG 3777
Query 3690 NVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFIT 3749
+++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V +L+ T
Sbjct 3778 RLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKWLAVNVLYFT 3833
Query 3750 G-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPP 3808
++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RYMN+ GL PP
Sbjct 3834 DVPQIKLVLLSYLCIGYVCCCYWGILSLLNSIFRMPLGVYNYKISVQELRYMNANGLRPP 3893
Query 3809 KSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQC 3868
++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L + S+SKLW C
Sbjct 3894 RNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHIASNSKLWQYC 3953
Query 3869 VQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLDNRATLQAIA 3922
LHN+IL D + AF+K+ LL VL + AVD I + ++ + + LQA+
Sbjct 3954 STLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVRDNTVLQALQ 4013
Query 3923 SEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM 3981
SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD A+ RKLE+M
Sbjct 4014 SEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDRAVARKLERM 4073
Query 3982 ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPL 4041
AD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA GCVPLN IP
Sbjct 4074 ADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPS 4133
Query 4042 TTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAW 4101
T+ L ++VPD + D TYA +W IQ + DAD + QL+EI++++ W
Sbjct 4134 LTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQFIQDADGAVKQLNEIDVNS----TW 4189
Query 4102 PLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVL 4159
PL++ A R N S V LQNNEL P LR +G+ T YYN + G+ V
Sbjct 4190 PLVIAANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYNTTGTGKIVY 4247
Query 4160 ALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMV 4219
A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG N L RG V
Sbjct 4248 AILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKGCNTLARGWV 4306
Query 4220 LGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHT 4279
+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+TNCVKMLC H
Sbjct 4307 VGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKMLCDHA 4366
Query 4280 GTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVG 4339
GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P DPV
Sbjct 4367 GTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVPLG-IKDPVS 4425
Query 4340 FTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
+ L + VC VCG W+ CSC + + FLNGF V
Sbjct 4426 YVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLNGFGV 4466
Score = 367 bits (943), Expect = 6e-100, Method: Composition-based stats.
Identities = 193/995 (19%), Positives = 334/995 (34%), Gaps = 167/995 (17%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPEYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDG---YPLDCI 201
E D E+ N K+ A L + G +VD C G L+
Sbjct 217 FNVE---DACEEVHLNPKGKYSCKAYA-LLKGYRGVKPILFVDQYGCDYTGCLAKGLEDY 272
Query 202 KDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSA 260
D TLSE + R D E +AW +R ++ QT ++
Sbjct 273 GDL---------TLSEMKELFPVWRDSL---DSEVLVAWHVDRDPRAAMRLQTLATVRCI 320
Query 261 KKFDTFKGEC---------PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE 311
+ P + N+ VK + PR+ + Y E
Sbjct 321 DYVGQPTEDVVDGDVVVREPAHLLAANAIVKRL-PRLVETMLYTDSSVTEFCY-KTKLCE 378
Query 312 CNNMHLSTLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVK 367
C + + C + CD W + + C + E + G +P V+
Sbjct 379 CGFITQFGYVDCCGDTCDFRGWVAGNMMDGFPCPGCTKNYMPWELEAQSSGVIPEGGVLF 438
Query 368 MPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRA 427
+ N E+ G FG V+ + C W+P
Sbjct 439 T-----------------QSTDTVNRESFKLYGHAVVPFGSAVY-WSPCPG---MWLPVI 477
Query 428 SADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAF 487
+ + S ++G+T V A
Sbjct 478 WSSVKS-YSGLTYTGVVGC--------------------------------------KAI 498
Query 488 IDTIKSLDYKSFKTIVES-CGNYKVTKGKPVKGA------WNIGQQRSVLTPLCGFPSQA 540
+ ++ + V+ CGN + + N G +L + F +
Sbjct 499 VQETDAICRSLYMDYVQHKCGNLEQRAILGLDDVYHRQLLVNRGDYSLLLENVDLFVKRR 558
Query 541 AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY 600
A + +P L V + + MV S +T+ + MA
Sbjct 559 AEFACKFA----TCGDGLVPLLLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMAL 614
Query 601 VTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFL 652
+ V+ ++++ + G V +R I EW + + W + L
Sbjct 615 LFMHDVKVATKYVKKVTGKLAVRFKALGVAVVRKITEWFDLAVDIAAS--AAGWLCYQ-L 671
Query 653 ITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTI---AGAKLRSLNLGEVF 709
+ G+F + G I + + + VK F+D ++ ID +++ +G + V
Sbjct 672 VNGLFAVANGVITFVQE-VPELVKNFVDKFKAFFKVLIDSMSVSILSGLTVVKTASNRVC 730
Query 710 IAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALE 767
+A SK + K +MP+ E T L G+ V + V + L +
Sbjct 731 LAGSKVY---EVVQKSLSAYVMPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLTYQGCC 786
Query 768 TPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRLKGGAPIKGV 824
P SF IV + L + + D+ + G+L F G K V
Sbjct 787 KPPTSFEKICIV------DKLYMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG----KKV 836
Query 825 TFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKT 883
F + V ++ + ++ITF LD D VL++ CS + V+ + E VV +AV T
Sbjct 837 EFNDKPKVRKIPSTRKIKITFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVEST 896
Query 884 LQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEE 940
L P + + T + LD + YLFD+ G+E + RMYCSF PD+E+ C
Sbjct 897 LSPCKEHDVIGTKVCALLDRLAGDYVYLFDEGGDEVIAPRMYCSFSAPDDED-----CVA 951
Query 941 EEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWL------DDTTEQSEIEPE 994
++ + E++ +D L + + + E + + + + +
Sbjct 952 ADVVDADENQDDDAEDSAVLVADTQEEDGVAKGQVEADSEICVAHTGSQEELAEPDAVGS 1011
Query 995 PEPTP---EEPVNQFTGYLKLTDNVAIKCVDIVKE 1026
P E V + + + + A C D V
Sbjct 1012 QTPIASAEETEVGEASDREGIAEAKATVCADAVDA 1046
Score = 174 bits (442), Expect = 1e-41, Method: Composition-based stats.
Identities = 52/156 (33%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + N VIVN AN + HG GVAGA+ + A KE+ D +K
Sbjct 1319 CITPNVCFVKGDVIKVVRLVNAEVIVNPANGRMAHGAGVAGAIAEKAGSAFIKETSDMVK 1378
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VG +G L KK L++VGP+ + LL+ AY++ N D ++ L+S
Sbjct 1379 AQGVCQVGECYESAGGKLCKKVLNIVGPDARGHGKQCYSLLERAYQHINKCDNVVTTLIS 1438
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N++ ++ +
Sbjct 1439 AGIFSVPTDVSLTYLLGVVTKNVILVSNNQDDFDVI 1474
Score = 42.8 bits (99), Expect = 0.10, Method: Composition-based stats.
Identities = 44/210 (21%), Positives = 78/210 (37%), Gaps = 21/210 (10%)
Query 1580 DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG 1639
++ K++ + E +T P+D T + + E+ Y + T F
Sbjct 1055 EIEKVEDSILDELQTELNAPADKTYE-DVLAFDAVCSEALSAFYAVPSDETH---FKVC- 1109
Query 1640 GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV 1699
G S NC+L S L+ +Q L ++F +Q+ + +AG F ++ K++
Sbjct 1110 GFYSPAIERTNCWLRSTLIVMQSLPLEFKDLEMQKLWLSYKAGYDQCFVDKLVKSVPKSI 1169
Query 1700 GEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLK 1757
G V + L S K N C C L G++A+ + G +
Sbjct 1170 ILPQGGYVADFAYFFLSQ---CSFKAYANWRCLECDM-ELKLQGLDAMFFYGDV------ 1219
Query 1758 TGVSIPCVCGRDATQYLVQQESSFVMMSAP 1787
VS C CG T L+ + + +
Sbjct 1220 --VSHMCKCGNSMT--LLSADIPYTLHFGV 1245
>sp|P0C6X9|R1AB_CVMA5 Replicase polyprotein 1ab OS=Murine coronavirus
(strain A59) OX=11142 GN=rep PE=1 SV=1
Length=7176
Score = 3647 bits (9458), Expect = 0.0, Method: Composition-based stats.
Identities = 1084/2919 (37%), Positives = 1601/2919 (55%), Gaps = 118/2919 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+ S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1596 KEASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1651
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
++GK FF A + DE L +Y + L KW G + K
Sbjct 1652 CSAIYKGKVFFQYSDLSEADLVAVKDAFGFDEPQLLKYYTMLGMC-KWPVVVCGNYFAFK 1710
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF QEA+ R+G F +L+LA + E D
Sbjct 1711 QSNNNCYINVACLMLQHLSLKFPKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1770
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ M +L+ A+L A L VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1771 IDFMRVVLREADLSGATCNLEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLVRGYNIACT 1829
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1830 CGSKLV-HCTQFNVPFLICSNTPEGRKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLY 1886
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D ++ K+SE KG TD Y K T + ++ LD V E +P L YY + YY
Sbjct 1887 DACNVNKVSEAKGNFTDCLYLKNLKQTFSSVLTTFYLDDVKCVEYKPDLSQYYCESGKYY 1946
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + + NFKL A+ LN GF E +T +P G
Sbjct 1947 TKPIIKAQFRTFEKVDGVYTNFKLV--GHSIAEKLNAKLGFDCNSPFVEYKITEWPTATG 2004
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP+VW ++ + + +P+ C ++ PVD
Sbjct 2005 DVVLASDDLYVSRYSSGCITFGKPVVWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2063
Query 1999 SNSFE------VLAVEDTQGMD----------NLACES---QQPTSEEVVENPTI----Q 2035
S + + V G D AC S + EV + P++
Sbjct 2064 SEPTDKGPVPAAVLVTGVPGADASAGAGIAKEQKACASASVEDQVVTEVRQEPSVSAADV 2123
Query 2036 KEVIECDVKTT-EVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLAL 2094
KEV VK +V G+V++ KV + L D+ ++ + NELS +
Sbjct 2124 KEVKLNGVKKPVKVEGSVVVNDPTSETKVVKSLSIVDVYDMFLTGCKYVVWTANELSRLV 2183
Query 2095 GLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLF 2154
T+ + + KI+ K L + K + + Y + LL+
Sbjct 2184 NSPTVREYVKWGMG-----KIVTPAKLLLLRDEKQEFVAPKVVKAKAIACYCAVKWFLLY 2238
Query 2155 QLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLS 2214
+T++++ T +A K KLC A N +++ +S + + +
Sbjct 2239 CFSWIKFNTDNKVI--YTTEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLVATVF 2293
Query 2215 ICLGSLICVTAAFG-VLLSNFGA-PSYCNGVRELYLNSSNVTTM-------------DFC 2259
+ + + L N G P++ + + + V+T+ FC
Sbjct 2294 LLWFNFLYANVILSDFYLPNIGPLPTFVGQIVAWFKTTFGVSTICDFYQVTDLGYRSSFC 2353
Query 2260 EGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYMLFTKFFYL 2317
GS C +C SG D LD+Y A+ +Q + +++ L E V+ Y L+T FY
Sbjct 2354 NGSMVCELCFSGFDMLDNYDAINVVQHVVDRRLSFDYISLFKLVVELVIGYSLYTVCFYP 2413
Query 2318 LGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYV 2375
L + MQ+ + F+ + W + + M P ++R YI + Y ++
Sbjct 2414 LFVLIGMQLLTTWLPEFFMLETMHWSARLFVFVANMLPAFTLLRFYIVVTAMYKVYCLCR 2473
Query 2376 HIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTF 2435
H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNCLNC+++
Sbjct 2474 HVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQWNCLNCNSW 2533
Query 2436 CTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPL 2495
G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ+ Y+
Sbjct 2534 KPGNTFITHEAAADLSKELKRPVNPTDSAYYSVTEVKQVGCSMRLFYERDGQRVYDDVNA 2593
Query 2496 SHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVS 2555
S FV+++ L + KG +V+V + ++ D++ A+V+Y+Q + +P+L++++ L++
Sbjct 2594 SLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLGAAVFYAQSLYRPMLMVEKKLIT 2651
Query 2556 DVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAAR 2615
VS MFD YVD+ V + L + V AH+ L +GV L+ V+ TF+ AR
Sbjct 2652 TANTGLSVSRTMFDLYVDSLLNVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDTFIGCAR 2711
Query 2616 QGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACIDCNAR 2674
+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG I NA+
Sbjct 2712 RKCAIDSDVETKSITKSVMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVLIQNNAK 2771
Query 2675 HINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTK 2734
H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V ++TT
Sbjct 2772 HVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANVPILTTP 2831
Query 2735 ISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVT 2794
SLKGG + S + + A L+C + V + +MP + + D +K I +GV
Sbjct 2832 FSLKGGAVFSRMLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASFKVIDNGVL 2888
Query 2795 RDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG + +P TVLR
Sbjct 2889 RDVSVTDACFANKFNQFDQWYESTFGLAYYRNSKACPVVVAVIDQDIGHTLFNVPTTVLR 2948
Query 2853 AINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD 2912
LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P PYCY
Sbjct 2949 -YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTPHPYCYT 3007
Query 2913 TNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEV 2971
++ + YS L P RY L + I+FP EG VRVV T YCR G CE +E
Sbjct 3008 GGVMHNASLYSSLAPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRVGLCEEAEE 3067
Query 2972 GICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIA 3031
GIC + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS VAG I+A
Sbjct 3068 GICFNFNRSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSVAGAILA 3127
Query 3032 ILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTF 3091
I+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ FY Y T
Sbjct 3128 IIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACFYFYTTL 3187
Query 3092 YFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFST 3151
YF +++S + HLQW M+ I+P W IYV + H W F+ +++ + T
Sbjct 3188 YFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFSYC--RKIGTEVRSDGT 3245
Query 3152 FEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHL 3211
FEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +YREAAC L
Sbjct 3246 FEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAAYREAACSQL 3303
Query 3212 AKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
AKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT G TLNGL
Sbjct 3304 AKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCIVSVTYGNMTLNGL 3363
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V +G + L V+ + MQ C L L
Sbjct 3364 WLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSGRMSLTVMSYQMQGCQLVLT 3423
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
V NP TPKY F ++PG+TF+VLA YNG P G + +R +HTIKGSFL GSCGSVG+
Sbjct 3424 VTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVTLRSSHTIKGSFLCGSCGSVGY 3483
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
+ D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+NV+AWLYA
Sbjct 3484 VLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTVNVVAWLYA 3543
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
A+ N WF+ + +L +FN+ AM + + D V L L++ TG+ V + AA+K
Sbjct 3544 AIFNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVEQVLAAIKR 3601
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L + I
Sbjct 3602 L-HSGFQGKQILGSCVLEDE-TPSDVYQQLAGVKLQSKRTRVIKGTCCWILASTFLFCSI 3659
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
+ +W++F +V + L TL + + AMLL+KHKH +L ++++P L T +V
Sbjct 3660 ISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLIKHKHLYLTMYIMPVLCTFYTNYLV 3718
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYDDAARRVWTLM 3689
S+ WL ++ Y D V+Y L++ ++ +T R++ D ++ +
Sbjct 3719 VYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHDVFSIMFLVG 3777
Query 3690 NVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFIT 3749
+++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V +L+ T
Sbjct 3778 RLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKWLAVNVLYFT 3833
Query 3750 G-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPP 3808
++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RYMN+ GL PP
Sbjct 3834 DVPQIKLVLLSYLCIGYVCCCYWGILSLLNSIFRMPLGVYNYKISVQELRYMNANGLRPP 3893
Query 3809 KSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQC 3868
++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L + S+SKLW C
Sbjct 3894 RNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHIASNSKLWQYC 3953
Query 3869 VQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLDNRATLQAIA 3922
LHN+IL D + AF+K+ LL VL + AVD I + ++ + + LQA+
Sbjct 3954 STLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVRDNTVLQALQ 4013
Query 3923 SEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM 3981
SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD A+ RKLE+M
Sbjct 4014 SEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDRAVARKLERM 4073
Query 3982 ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPL 4041
AD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA GCVPLN IP
Sbjct 4074 ADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVKGCVPLNAIPS 4133
Query 4042 TTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAW 4101
T+ L ++VPD + D TYA +W IQ + DAD + QL+EI++++ W
Sbjct 4134 LTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQFIQDADGAVKQLNEIDVNS----TW 4189
Query 4102 PLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVL 4159
PL++ A R N S V LQNNEL P LR +G+ T YYN + G+ V
Sbjct 4190 PLVIAANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYNTTGTGKIVY 4247
Query 4160 ALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMV 4219
A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG N L RG V
Sbjct 4248 AILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKGCNTLARGWV 4306
Query 4220 LGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHT 4279
+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+TNCVKMLC H
Sbjct 4307 VGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKMLCDHA 4366
Query 4280 GTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVG 4339
GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P DPV
Sbjct 4367 GTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVPLG-IKDPVS 4425
Query 4340 FTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
+ L + VC VCG W+ CSC + + FLN
Sbjct 4426 YVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLN 4462
Score = 358 bits (918), Expect = 5e-97, Method: Composition-based stats.
Identities = 197/1004 (20%), Positives = 336/1004 (33%), Gaps = 185/1004 (18%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPEYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDG---YPLDCI 201
E D E+ N K+ A L + G +VD C G L+
Sbjct 217 FNVE---DACEEVHLNPKGKYSCKAYA-LLKGYRGVKPILFVDQYGCDYTGCLAKGLEDY 272
Query 202 KDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSA 260
D TLSE + R D E +AW +R ++ QT ++
Sbjct 273 GDL---------TLSEMKELFPVWRDSL---DSEVLVAWHVDRDPRAAMRLQTLATVRCI 320
Query 261 KKFDTFKGEC---------PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE 311
+ P + N+ VK + PR+ + Y E
Sbjct 321 DYVGQPTEDVVDGDVVVREPAHLLAANAIVKRL-PRLVETMLYTDSSVTEFCY-KTKLCE 378
Query 312 CNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCP 371
C + + C C + TCDF G++ N + PCP
Sbjct 379 CGFITQFGYVDC--CGD----TCDF--------------------RGWVAGNMMDGFPCP 412
Query 372 ACQDP------EIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVP 425
C E + + T + +G V VP
Sbjct 413 GCTKNYMPWELEAQSSGVIPEGGVLFTQSTDTVNRESFKLYGHAV-------------VP 459
Query 426 RASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTS 485
SA S G+ + + + + G
Sbjct 460 FGSAVYWSPCPGMWLPVIWSS--------VKSYSGLTYTG---------------VVGCK 496
Query 486 AFIDTIKSLDYKSFKTIVES-CGNYKVTKGKPVKGA------WNIGQQRSVLTPLCGFPS 538
A + ++ + V+ CGN + + N G +L + F
Sbjct 497 AIVQETDAICRSLYMDYVQHKCGNLEQRAILGLDDVYHRQLLVNRGDYSLLLENVDLFVK 556
Query 539 QAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDA-------MVYTSDLL 591
+ A + D +LDG+ +S L+ + MV S +
Sbjct 557 RRAEFACKFA---------TCGD--GLVPLLLDGLVPRSYYLIKSGQAFTSMMVNFSHEV 605
Query 592 TNSVIIMAYVTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLK 643
T+ + MA + V+ ++++ + G V +R I EW + +
Sbjct 606 TDMCMDMALLFMHDVKVATKYVKKVTGKLAVRFKALGVAVVRKITEWFDLAVDIAAS--A 663
Query 644 DAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIA---GAKL 700
W + L+ G+F + G I + + + VK F+D ++ ID ++++ G +
Sbjct 664 AGWLCYQ-LVNGLFAVANGVITFVQE-VPELVKNFVDKFKAFFKVLIDSMSVSILSGLTV 721
Query 701 RSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKN 760
V +A SK + K +MP+ E T L G+ V + V +
Sbjct 722 VKTASNRVCLAGSKVY---EVVQKSLSAYVMPVGC-SEATCLVGEIEPAVFEDDVVDVVK 777
Query 761 GEL--EALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRL 815
L + P SF IV + L + + D+ + G+L F
Sbjct 778 APLTYQGCCKPPTSFEKICIV------DKLYMAKCGDQFYPVVVDNDTVGVLDQCWRFPC 831
Query 816 KGGAPIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFAC 874
G K V F + V ++ + ++ITF LD D VL++ CS + V+ + E
Sbjct 832 AG----KKVEFNDKPKVRKIPSTRKIKITFALDATFDSVLSKACSEFEVDKDVTLDELLD 887
Query 875 VVAEAVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEE 931
VV +AV TL P + + T + LD + YLFD+ G+E + RMYCSF PD+E
Sbjct 888 VVLDAVESTLSPCKEHDVIGTKVCALLDRLAGDYVYLFDEGGDEVIAPRMYCSFSAPDDE 947
Query 932 EEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWL------DDT 985
+ C ++ + E++ +D L + + + E + + +
Sbjct 948 D-----CVAADVVDADENQDDDAEDSAVLVADTQEEDGVAKGQVEADSEICVAHTGSQEE 1002
Query 986 TEQSEIEPEPEPTP---EEPVNQFTGYLKLTDNVAIKCVDIVKE 1026
+ + P E V + + + + A C D V
Sbjct 1003 LAEPDAVGSQTPIASAEETEVGEASDREGIAEAKATVCADAVDA 1046
Score = 174 bits (442), Expect = 1e-41, Method: Composition-based stats.
Identities = 52/156 (33%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + N VIVN AN + HG GVAGA+ + A KE+ D +K
Sbjct 1319 CITPNVCFVKGDVIKVVRLVNAEVIVNPANGRMAHGAGVAGAIAEKAGSAFIKETSDMVK 1378
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VG +G L KK L++VGP+ + LL+ AY++ N D ++ L+S
Sbjct 1379 AQGVCQVGECYESAGGKLCKKVLNIVGPDARGHGKQCYSLLERAYQHINKCDNVVTTLIS 1438
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N++ ++ +
Sbjct 1439 AGIFSVPTDVSLTYLLGVVTKNVILVSNNQDDFDVI 1474
Score = 43.2 bits (100), Expect = 0.099, Method: Composition-based stats.
Identities = 44/210 (21%), Positives = 78/210 (37%), Gaps = 21/210 (10%)
Query 1580 DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG 1639
++ K++ + E +T P+D T + + E+ Y + T F
Sbjct 1055 EIEKVEDSILDELQTELNAPADKTYE-DVLAFDAVCSEALSAFYAVPSDETH---FKVC- 1109
Query 1640 GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV 1699
G S NC+L S L+ +Q L ++F +Q+ + +AG F ++ K++
Sbjct 1110 GFYSPAIERTNCWLRSTLIVMQSLPLEFKDLEMQKLWLSYKAGYDQCFVDKLVKSVPKSI 1169
Query 1700 GEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLK 1757
G V + L S K N C C L G++A+ + G +
Sbjct 1170 ILPQGGYVADFAYFFLSQ---CSFKAYANWRCLECDM-ELKLQGLDAMFFYGDV------ 1219
Query 1758 TGVSIPCVCGRDATQYLVQQESSFVMMSAP 1787
VS C CG T L+ + + +
Sbjct 1220 --VSHMCKCGNSMT--LLSADIPYTLHFGV 1245
>sp|P0C6Y0|R1AB_CVMJH Replicase polyprotein 1ab OS=Murine coronavirus
(strain JHM) OX=11144 GN=rep PE=1 SV=1
Length=7180
Score = 3643 bits (9447), Expect = 0.0, Method: Composition-based stats.
Identities = 1078/2929 (37%), Positives = 1591/2929 (54%), Gaps = 131/2929 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+ S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1595 KEASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1650
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
H+GK FF A + DE L +Y S L KW G + K
Sbjct 1651 CSAIHKGKVFFQYSGLSAADLAAVKDAFGFDEPQLLQYYSMLGMC-KWPVVVCGNYFAFK 1709
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF + R+G F +L+LA + E D
Sbjct 1710 QSNNNCYINVACLMLQHLSLKFPKWQWRRPGNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1769
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ + L+ A+L A L +CK CG K GV+AVM+ GTL L G +I C
Sbjct 1770 TDFIRVELREADLSGATCDLEFICK-CGVKQEQRKGVDAVMHFGTLDKSGLVKGYNIACT 1828
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG D + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1829 CG-DKLVHCTQFNVPFLICSNTPEGKKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLY 1885
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D +++K+SE KG TD Y K T + +Y LD V +P L YY + YY
Sbjct 1886 DACNVSKVSEAKGNFTDCLYLKNLKQTFSSVLTTYYLDDVKCVAYKPDLSQYYCESGKYY 1945
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + NFKL A+ LN GF E +T +P G
Sbjct 1946 TKPIIKAQFRTFEKVEGVYTNFKLV--GHDIAEKLNAKLGFDCNSPFMEYKITEWPTATG 2003
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP++W ++ + + +P+ C ++ PVD
Sbjct 2004 DVVLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2062
Query 1999 SNSFE--------------------VLAVEDTQGMDNLACESQQPTSEEVVENP------ 2032
S + ++ E + AC S + V+E
Sbjct 2063 SEPTDRRPVPSAVLVTGAASGADASAISTEPGTAKEQKACASDSVEDQIVMEAQKKSSVT 2122
Query 2033 -TIQKEVIECDVKTT-EVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNEL 2090
KEV VK + +V++ KV + L D+ ++ + NEL
Sbjct 2123 TVAVKEVKLNGVKKPVKWNCSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWTANEL 2182
Query 2091 SLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVF 2150
S + T+ + + SK++ L + K + + Y +
Sbjct 2183 SRLINSPTVREYVKWGM-----SKLIIPANLLLLRDEKQEFVAPKVVKAKAIACYGAVKW 2237
Query 2151 TLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTI 2206
LL+ +T++++ T +A K KLC A N +++ +S F +
Sbjct 2238 FLLYCFSWIKFNTDNKVI--YTTEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLV 2292
Query 2207 AMWLLLLSICLGSLI---------------CVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
A LL L + + V + + FG + C+ Y +
Sbjct 2293 ATVFLLWFNFLYANVILSDFYLPNIGPLPMFVGQIVAWVKTTFGVLTICD----FYQVTD 2348
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYM 2309
FC GS C +C SG D LD+Y ++ +Q + +++ L E V+ Y
Sbjct 2349 LGYRSSFCNGSMVCELCFSGFDMLDNYESINVVQHVVDRRVSFDYISLFKLVVELVIGYS 2408
Query 2310 LFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASF 2367
L+T FY L + MQ+ + F+ + W + + M P ++R YI +
Sbjct 2409 LYTVCFYPLFVLVGMQLLTTWLPEFFMLGTMHWSARLFVFVANMLPAFTLLRFYIVVTAM 2468
Query 2368 YYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNW 2427
Y ++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H W
Sbjct 2469 YKVYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQW 2528
Query 2428 NCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQ 2487
NCLNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ
Sbjct 2529 NCLNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVIEVKQVGCSMRLFYERDGQ 2588
Query 2488 KTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPIL 2547
+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +P+L
Sbjct 2589 RVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYRPML 2646
Query 2548 LLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVL 2607
++++ L++ VS MFD YV + V + L + V AH+ L +GV L+ V+
Sbjct 2647 MVEKKLITTANTGLSVSRTMFDLYVYSLLRHLDVDRKSLTSFVNAAHNSLKEGVQLEQVM 2706
Query 2608 STFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLG 2666
TFV AR+ +D+DV+TK + + + + ++ +EVT +SCNN + TY K + + DLG
Sbjct 2707 DTFVGCARRKCAIDSDVETKSITKSVMAAVNAGVEVTDESCNNLVPTYVKSDTIVAADLG 2766
Query 2667 ACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQ 2726
I NA+H+ + VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2767 VLIQNNAKHVQSNVAKAANVACIWSVDAFNQLSADLQHRLRKACVKTGLKIKLTYNKQEA 2826
Query 2727 VVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGY 2786
V ++TT SLKGG + S + + A L+C + V + +MP + + D +
Sbjct 2827 NVPILTTPFSLKGGAVFSRVLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASF 2883
Query 2787 KAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVP 2844
K I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG +
Sbjct 2884 KVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLVYYRNSKACPVVVAVIDQDIGHTLF 2943
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G
Sbjct 2944 NVPTKVLR-YGFHVLHFITHAFATDRVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADG 3002
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P PYCY ++ + YS L P RY L + I+FP EG VRVV T YCR
Sbjct 3003 TPHPYCYTEGVMHNASLYSSLVPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRV 3062
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LVQP+ ++AS
Sbjct 3063 GLCEEAEEGICFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVQPIDFFALTAS 3122
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+
Sbjct 3123 SVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYA 3182
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVM 3143
FY Y T YF +++S + HLQW M+ I+P W YV + H W F+ +++
Sbjct 3183 CFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCITYVAVVVSNHALWLFSYC--RKIG 3240
Query 3144 FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSY 3203
+ + TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +Y
Sbjct 3241 TDVRSDGTFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTATY 3298
Query 3204 REAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTC 3262
REAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT
Sbjct 3299 REAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCVVSVTY 3358
Query 3263 GTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSM 3322
G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V + + L V+ + M
Sbjct 3359 GNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSDRMSLTVMSYQM 3418
Query 3323 QNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLN 3382
Q LL L V NP TPKY F ++PG+TF+VLA YNG P G + MR +HTIKGSFL
Sbjct 3419 QGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVVMRSSHTIKGSFLC 3478
Query 3383 GSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITL 3442
GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+
Sbjct 3479 GSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTV 3538
Query 3443 NVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVL 3502
NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ TG+ V
Sbjct 3539 NVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVE 3596
Query 3503 DMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLL 3562
+ AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L
Sbjct 3597 QVLAAIKRL-HSGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVIKGTCCWILA 3655
Query 3563 TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLA 3622
+ I+ +W++F +V + L TL + AMLL+KHKH +L ++++P L
Sbjct 3656 STFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVIFAMLLIKHKHLYLTMYIMPVLC 3714
Query 3623 TVAYFNMVY--MPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYD 3679
T+ Y N + S+ WL ++ Y D V+Y L++ ++ +T R++
Sbjct 3715 TLFYTNYLVVGYKQSFRGLAYAWLSYFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINH 3773
Query 3680 DAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVC 3739
D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3774 DVFSTMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAK 3829
Query 3740 VEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFR 3798
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE R
Sbjct 3830 WLAVNVLYFTDIPQIKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKISVQELR 3889
Query 3799 YMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRV 3858
YMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L +
Sbjct 3890 YMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHI 3949
Query 3859 ESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEML 3912
S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ +
Sbjct 3950 ASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYV 4009
Query 3913 DNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRD 3971
+ LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD
Sbjct 4010 RDNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERD 4069
Query 3972 AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARD 4031
A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA
Sbjct 4070 RAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVK 4129
Query 4032 GCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEI 4091
GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI
Sbjct 4130 GCVPLNAIPPLTSNTLTIIVPDKQVFDQVVDNVYVTYAPNVWHIQSIQDADGAVKQLNEI 4189
Query 4092 NMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYY 4149
++++ WPL+++A R N S V LQNNEL P LR +G+ YY
Sbjct 4190 DVNS----TWPLVISANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNIPTQ--CYY 4243
Query 4150 NNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIK 4209
N + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+K
Sbjct 4244 NTTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVK 4302
Query 4210 GLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPIT 4269
G N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+T
Sbjct 4303 GCNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIQQGGVPVT 4362
Query 4270 NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQI 4329
NCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+
Sbjct 4363 NCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQV 4422
Query 4330 PTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
P DPV + L + VC VCG W+ CSC + + FLN
Sbjct 4423 PLG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLN 4468
Score = 371 bits (952), Expect = 6e-101, Method: Composition-based stats.
Identities = 202/997 (20%), Positives = 335/997 (34%), Gaps = 172/997 (17%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPEYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDG---YPLDCI 201
E D E+ N K+ A L R G +VD C G L+
Sbjct 217 FNVE---DACEEVHLNPRGKYSCKAYA-LLRGYRGVKPILFVDQYGCDYTGCLAKGLEDY 272
Query 202 KDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSA 260
D TLSE + R D+E +AW +R ++ QT ++S
Sbjct 273 GDL---------TLSEMKELSPVWRDSL---DNEVVVAWHVDRDPRAVMRLQTLATVRSI 320
Query 261 KKF-----DTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE 311
+ D G+ P + N+ VK + PR+ + Y +
Sbjct 321 EYVGQPIEDMVDGDVVMREPAHLLAPNAIVKRL-PRLVETMLYTDSSVTEFCY-KTKLCD 378
Query 312 CNNMHLSTLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVK 367
C + + C + C W + + C + E + G +P V+
Sbjct 379 CGFITQFGYVDCCGDTCGFRGWVPGNMMDGFPCPGCCKSYMPWELEAQSSGVIPEGGVLF 438
Query 368 MPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRA 427
+ N E+ G FGG AY Y W+P
Sbjct 439 T-----------------QSTDTVNRESFKLYGHAVVPFGGA--AYWSPYPGM--WLPVI 477
Query 428 SADIGS----GHTGITG-DNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSA 482
+ + S +TG+ G + + + L ++ V N E IL
Sbjct 478 WSSVKSYSYLTYTGVVGCKAIVQETDAICRFLY-----MDYVQHKCGNLEQRAIL----- 527
Query 483 STSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAG 542
LD + ++ + G+Y + N+
Sbjct 528 ----------GLDDVYHRQLLVNRGDYSLLL-------ENVDLF---------------- 554
Query 543 VIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDA-------MVYTSDLLTNSV 595
R + A +LDG+ +S L+ + MV S + +
Sbjct 555 -----VKRRAEFACKFATCGDGLVPLLLDGLVPRSYYLIKSGQAFTSLMVNFSREVVDMC 609
Query 596 IIMAYVTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLKDAWE 647
+ MA + V+ ++++ + G + +R I EW + + W
Sbjct 610 MDMALLFMHDVKVATKYVKKVTGKVAVRFKALGIAVVRKITEWFDLAVDTAAS--AAGWL 667
Query 648 ILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIA---GAKLRSLN 704
+ L+ G+F + G I + + + VK F+D ++ ID ++++ G +
Sbjct 668 CYQ-LVNGLFAVANGVITFIQE-VPELVKNFVDKFKTFFKVLIDSMSVSILSGLTVVKTA 725
Query 705 LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL- 763
V +A SK + K +MP+ E T L G+ V + V + L
Sbjct 726 SNRVCLAGSKVY---EVVQKSLPAYIMPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLT 781
Query 764 -EALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRLKGGA 819
+ P SF IV + L + + D+ + G+L F G
Sbjct 782 YQGCCKPPSSFEKICIV------DKLYMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG-- 833
Query 820 PIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAE 878
K V F + V EV + ++I F LD D VL++ CS + V+ + E VV +
Sbjct 834 --KKVVFNDKPKVKEVPSTRKIKIIFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLD 891
Query 879 AVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDD 935
AV TL P + + T + L+ YLFD+ GEE +SRMYCSF PDE+
Sbjct 892 AVESTLSPCKEHGVIGTKVCALLERLVDDYVYLFDEGGEEVIASRMYCSFSAPDEDCVAT 951
Query 936 AECEEEE------IDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQS 989
+E D E+D A +E +E +
Sbjct 952 DVVYADENQDDDADDPVVLVADTQEEDGVAREQVDSADSEICVAHTGGQEMT---EPDVV 1008
Query 990 EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKE 1026
+ E V + + + A C D +
Sbjct 1009 GSQTPIASAEETEVGEACDREGIAEVKATVCADALDA 1045
Score = 141 bits (354), Expect = 2e-31, Method: Composition-based stats.
Identities = 54/156 (35%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + VIVN AN + HG GVAGA+ KA A E+ D +K
Sbjct 1318 CITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKAFINETADMVK 1377
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VGG +G L KK L++VGP+ E LL+ AY++ N D ++ L+S
Sbjct 1378 AQGVCQVGGCYESTGGKLCKKVLNIVGPDARGHGNECYSLLERAYQHINKCDNVVTTLIS 1437
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N++ ++ +
Sbjct 1438 AGIFSVPTDVSLTYLLGVVTKNVILVSNNQDDFDVI 1473
Score = 46.2 bits (108), Expect = 0.009, Method: Composition-based stats.
Identities = 47/204 (23%), Positives = 79/204 (39%), Gaps = 21/204 (10%)
Query 1580 DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG 1639
D+ K++ + E +T P+D T + + E+ Y + T F
Sbjct 1054 DIEKVEDSILSELQTELNAPADKTYE-DVLAFDAIYSETLSAFYAVPSDETH---FKVC- 1108
Query 1640 GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV 1699
G S NC+L S L+ +Q L ++F +Q+ + +AG F ++ + K++
Sbjct 1109 GFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKLVKSAPKSI 1168
Query 1700 GEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLK 1757
G V + L S K N C CG L G++AV + G +
Sbjct 1169 ILPQGGYVADFAYFFLSQ---CSFKVHANWRCLKCGM-ELKLQGLDAVFFYGDV------ 1218
Query 1758 TGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG T L+ + +
Sbjct 1219 --VSHMCKCGNSMT--LLSADIPY 1238
>sp|P0C6V1|R1A_CVMJH Replicase polyprotein 1a OS=Murine coronavirus
(strain JHM) OX=11144 GN=1a PE=1 SV=1
Length=4474
Score = 3643 bits (9446), Expect = 0.0, Method: Composition-based stats.
Identities = 1081/2933 (37%), Positives = 1594/2933 (54%), Gaps = 131/2933 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+ S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1595 KEASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1650
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
H+GK FF A + DE L +Y S L KW G + K
Sbjct 1651 CSAIHKGKVFFQYSGLSAADLAAVKDAFGFDEPQLLQYYSMLGMC-KWPVVVCGNYFAFK 1709
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF + R+G F +L+LA + E D
Sbjct 1710 QSNNNCYINVACLMLQHLSLKFPKWQWRRPGNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1769
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ + L+ A+L A L +CK CG K GV+AVM+ GTL L G +I C
Sbjct 1770 TDFIRVELREADLSGATCDLEFICK-CGVKQEQRKGVDAVMHFGTLDKSGLVKGYNIACT 1828
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG D + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1829 CG-DKLVHCTQFNVPFLICSNTPEGKKLPDDV-VAANIFTGG-SVGHYTHVKCKPKYQLY 1885
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D +++K+SE KG TD Y K T + +Y LD V +P L YY + YY
Sbjct 1886 DACNVSKVSEAKGNFTDCLYLKNLKQTFSSVLTTYYLDDVKCVAYKPDLSQYYCESGKYY 1945
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + NFKL A+ LN GF E +T +P G
Sbjct 1946 TKPIIKAQFRTFEKVEGVYTNFKLV--GHDIAEKLNAKLGFDCNSPFMEYKITEWPTATG 2003
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP++W ++ + + +P+ C ++ PVD
Sbjct 2004 DVVLASDDLYVSRYSGGCVTFGKPVIWRGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2062
Query 1999 SNSFE--------------------VLAVEDTQGMDNLACESQQPTSEEVVENP------ 2032
S + ++ E + AC S + V+E
Sbjct 2063 SEPTDRRPVPSAVLVTGAASGADASAISTEPGTAKEQKACASDSVEDQIVMEAQKKSSVT 2122
Query 2033 -TIQKEVIECDVKTT-EVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNEL 2090
KEV VK + +V++ KV + L D+ ++ + NEL
Sbjct 2123 TVAVKEVKLNGVKKPVKWNCSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWTANEL 2182
Query 2091 SLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVF 2150
S + T+ + + SK++ L + K + + Y +
Sbjct 2183 SRLINSPTVREYVKWGM-----SKLIIPANLLLLRDEKQEFVAPKVVKAKAIACYGAVKW 2237
Query 2151 TLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTI 2206
LL+ +T++++ T +A K KLC A N +++ +S F +
Sbjct 2238 FLLYCFSWIKFNTDNKVI--YTTEVAS---KLTFKLCCLAFKNALQTFNWSVVSRGFFLV 2292
Query 2207 AMWLLLLSICLGSLI---------------CVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
A LL L + + V + + FG + C+ Y +
Sbjct 2293 ATVFLLWFNFLYANVILSDFYLPNIGPLPMFVGQIVAWVKTTFGVLTICD----FYQVTD 2348
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYM 2309
FC GS C +C SG D LD+Y ++ +Q + +++ L E V+ Y
Sbjct 2349 LGYRSSFCNGSMVCELCFSGFDMLDNYESINVVQHVVDRRVSFDYISLFKLVVELVIGYS 2408
Query 2310 LFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASF 2367
L+T FY L + MQ+ + F+ + W + + M P ++R YI +
Sbjct 2409 LYTVCFYPLFVLVGMQLLTTWLPEFFMLGTMHWSARLFVFVANMLPAFTLLRFYIVVTAM 2468
Query 2368 YYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNW 2427
Y ++ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H W
Sbjct 2469 YKVYCLCRHVMYGCSKPGCLFCYKRNRSVRVKCSTVVGGSLRYYDVMANGGTGFCTKHQW 2528
Query 2428 NCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQ 2487
NCLNC+++ G+TFI+ E A DLS + KRP+NPTD + Y V V ++ L++++ GQ
Sbjct 2529 NCLNCNSWKPGNTFITHEAAADLSKELKRPVNPTDSAYYSVIEVKQVGCSMRLFYERDGQ 2588
Query 2488 KTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPIL 2547
+ Y+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +P+L
Sbjct 2589 RVYDDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYRPML 2646
Query 2548 LLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVL 2607
++++ L++ VS MFD YV + V + L + V AH+ L +GV L+ V+
Sbjct 2647 MVEKKLITTANTGLSVSRTMFDLYVYSLLRHLDVDRKSLTSFVNAAHNSLKEGVQLEQVM 2706
Query 2608 STFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLG 2666
TFV AR+ +D+DV+TK + + + + ++ +EVT +SCNN + TY K + + DLG
Sbjct 2707 DTFVGCARRKCAIDSDVETKSITKSVMAAVNAGVEVTDESCNNLVPTYVKSDTIVAADLG 2766
Query 2667 ACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQ 2726
I NA+H+ + VAK+ NV+ IW+V + LS L+ ++R A K + +LT
Sbjct 2767 VLIQNNAKHVQSNVAKAANVACIWSVDAFNQLSADLQHRLRKACVKTGLKIKLTYNKQEA 2826
Query 2727 VVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGY 2786
V ++TT SLKGG + S + + A L+C + V + +MP + + D +
Sbjct 2827 NVPILTTPFSLKGGAVFSRVLQWLFVANLICFI---VLWALMPTYAVHKSDMQLPLYASF 2883
Query 2787 KAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVP 2844
K I +GV RD+ TD CFANK FD W+ G Y+N K+CPVV A+I ++IG +
Sbjct 2884 KVIDNGVLRDVSVTDACFANKFNQFDQWYESTFGLVYYRNSKACPVVVAVIDQDIGHTLF 2943
Query 2845 GLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMG 2904
+P VLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G
Sbjct 2944 NVPTKVLR-YGFHVLHFITHAFATDRVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADG 3002
Query 2905 KPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRH 2963
P PYCY ++ + YS L P RY L + I+FP EG VRVV T YCR
Sbjct 3003 TPHPYCYTEGVMHNASLYSSLVPHVRYNLASSNGYIRFPEVVSEGIVRVVRTRSMTYCRV 3062
Query 2964 GTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSAS 3023
G CE +E GIC + + WVLNN +YRA+ G FCG +A +LI + LVQP+ ++AS
Sbjct 3063 GLCEEAEEGICFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVQPIDFFALTAS 3122
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
VAG I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+
Sbjct 3123 SVAGAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYA 3182
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVM 3143
FY Y T YF +++S + HLQW M+ I+P W YV + H W F+ +++
Sbjct 3183 CFYFYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCITYVAVVVSNHALWLFSYC--RKIG 3240
Query 3144 FNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSY 3203
+ + TFEE AL TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +Y
Sbjct 3241 TDVRSDGTFEEMALTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTATY 3298
Query 3204 REAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTC 3262
REAAC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM P+ KVE C+V VT
Sbjct 3299 REAACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVSPTSKVEPCVVSVTY 3358
Query 3263 GTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSM 3322
G TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R ++ F V + + L V+ + M
Sbjct 3359 GNMTLNGLWLDDKVYCPRHVICSSADMTDPDYPNLLCRVTSSDFCVMSDRMSLTVMSYQM 3418
Query 3323 QNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLN 3382
Q LL L V NP TPKY F ++PG+TF+VLA YNG P G + MR +HTIKGSFL
Sbjct 3419 QGSLLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGRPQGAFHVVMRSSHTIKGSFLC 3478
Query 3383 GSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITL 3442
GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+
Sbjct 3479 GSCGSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTV 3538
Query 3443 NVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVL 3502
NV+AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ TG+ V
Sbjct 3539 NVVAWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVE 3596
Query 3503 DMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLL 3562
+ AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K +++KGT W+L
Sbjct 3597 QVLAAIKRL-HSGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVIKGTCCWILA 3655
Query 3563 TFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLA 3622
+ I+ +W++F +V + L TL + AMLL+KHKH +L ++++P L
Sbjct 3656 STFLFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVIFAMLLIKHKHLYLTMYIMPVLC 3714
Query 3623 TVAYFNMVY--MPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYD 3679
T+ Y N + S+ WL ++ Y D V+Y L++ ++ +T R++
Sbjct 3715 TLFYTNYLVVGYKQSFRGLAYAWLSYFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINH 3773
Query 3680 DAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVC 3739
D ++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3774 DVFSTMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAK 3829
Query 3740 VEYYPLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFR 3798
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE R
Sbjct 3830 WLAVNVLYFTDIPQIKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKISVQELR 3889
Query 3799 YMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRV 3858
YMN+ GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L +
Sbjct 3890 YMNANGLRPPRNSFEALMLNFKLLGIGGVPVIEVSQIQSRLTDVKCANVVLLNCLQHLHI 3949
Query 3859 ESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEML 3912
S+SKLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ +
Sbjct 3950 ASNSKLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYV 4009
Query 3913 DNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRD 3971
+ LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD
Sbjct 4010 RDNTVLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERD 4069
Query 3972 AAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARD 4031
A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA
Sbjct 4070 RAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQALNSILDNAVK 4129
Query 4032 GCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEI 4091
GCVPLN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI
Sbjct 4130 GCVPLNAIPPLTSNTLTIIVPDKQVFDQVVDNVYVTYAPNVWHIQSIQDADGAVKQLNEI 4189
Query 4092 NMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYY 4149
++++ WPL+++A R N S V LQNNEL P LR +G+ YY
Sbjct 4190 DVNS----TWPLVISANRHNEVSTVVLQNNELMPQKLRTQVVNSGSDMNCNIPTQ--CYY 4243
Query 4150 NNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIK 4209
N + G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+K
Sbjct 4244 NTTGTGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVK 4302
Query 4210 GLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPIT 4269
G N L RG V+G+L++TVRLQAG ATE +NS +LS CAF+VDP K Y DY+ GG P+T
Sbjct 4303 GCNTLARGWVVGTLSSTVRLQAGTATEYASNSAILSLCAFSVDPKKTYLDYIQQGGVPVT 4362
Query 4270 NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQI 4329
NCVKMLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+
Sbjct 4363 NCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQV 4422
Query 4330 PTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
P DPV + L + VC VCG W+ CSC + + FLNGF V
Sbjct 4423 PLG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLNGFGV 4472
Score = 370 bits (949), Expect = 1e-100, Method: Composition-based stats.
Identities = 202/997 (20%), Positives = 335/997 (34%), Gaps = 172/997 (17%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPEYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDG---YPLDCI 201
E D E+ N K+ A L R G +VD C G L+
Sbjct 217 FNVE---DACEEVHLNPRGKYSCKAYA-LLRGYRGVKPILFVDQYGCDYTGCLAKGLEDY 272
Query 202 KDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSA 260
D TLSE + R D+E +AW +R ++ QT ++S
Sbjct 273 GDL---------TLSEMKELSPVWRDSL---DNEVVVAWHVDRDPRAVMRLQTLATVRSI 320
Query 261 KKF-----DTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE 311
+ D G+ P + N+ VK + PR+ + Y +
Sbjct 321 EYVGQPIEDMVDGDVVMREPAHLLAPNAIVKRL-PRLVETMLYTDSSVTEFCY-KTKLCD 378
Query 312 CNNMHLSTLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVK 367
C + + C + C W + + C + E + G +P V+
Sbjct 379 CGFITQFGYVDCCGDTCGFRGWVPGNMMDGFPCPGCCKSYMPWELEAQSSGVIPEGGVLF 438
Query 368 MPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRA 427
+ N E+ G FGG AY Y W+P
Sbjct 439 T-----------------QSTDTVNRESFKLYGHAVVPFGGA--AYWSPYPGM--WLPVI 477
Query 428 SADIGS----GHTGITG-DNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSA 482
+ + S +TG+ G + + + L ++ V N E IL
Sbjct 478 WSSVKSYSYLTYTGVVGCKAIVQETDAICRFLY-----MDYVQHKCGNLEQRAIL----- 527
Query 483 STSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAG 542
LD + ++ + G+Y + N+
Sbjct 528 ----------GLDDVYHRQLLVNRGDYSLLL-------ENVDLF---------------- 554
Query 543 VIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDA-------MVYTSDLLTNSV 595
R + A +LDG+ +S L+ + MV S + +
Sbjct 555 -----VKRRAEFACKFATCGDGLVPLLLDGLVPRSYYLIKSGQAFTSLMVNFSREVVDMC 609
Query 596 IIMAYVTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLKDAWE 647
+ MA + V+ ++++ + G + +R I EW + + W
Sbjct 610 MDMALLFMHDVKVATKYVKKVTGKVAVRFKALGIAVVRKITEWFDLAVDTAAS--AAGWL 667
Query 648 ILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIA---GAKLRSLN 704
+ L+ G+F + G I + + + VK F+D ++ ID ++++ G +
Sbjct 668 CYQ-LVNGLFAVANGVITFIQE-VPELVKNFVDKFKTFFKVLIDSMSVSILSGLTVVKTA 725
Query 705 LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL- 763
V +A SK + K +MP+ E T L G+ V + V + L
Sbjct 726 SNRVCLAGSKVY---EVVQKSLPAYIMPVGC-SEATCLVGEIEPAVFEDDVVDVVKAPLT 781
Query 764 -EALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRLKGGA 819
+ P SF IV + L + + D+ + G+L F G
Sbjct 782 YQGCCKPPSSFEKICIV------DKLYMAKCGDQFYPVVVDNDTVGVLDQCWRFPCAG-- 833
Query 820 PIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAE 878
K V F + V EV + ++I F LD D VL++ CS + V+ + E VV +
Sbjct 834 --KKVVFNDKPKVKEVPSTRKIKIIFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLD 891
Query 879 AVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDD 935
AV TL P + + T + L+ YLFD+ GEE +SRMYCSF PDE+
Sbjct 892 AVESTLSPCKEHGVIGTKVCALLERLVDDYVYLFDEGGEEVIASRMYCSFSAPDEDCVAT 951
Query 936 AECEEEE------IDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQS 989
+E D E+D A +E +E +
Sbjct 952 DVVYADENQDDDADDPVVLVADTQEEDGVAREQVDSADSEICVAHTGGQEMT---EPDVV 1008
Query 990 EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKE 1026
+ E V + + + A C D +
Sbjct 1009 GSQTPIASAEETEVGEACDREGIAEVKATVCADALDA 1045
Score = 141 bits (354), Expect = 3e-31, Method: Composition-based stats.
Identities = 54/156 (35%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + VIVN AN + HG GVAGA+ KA A E+ D +K
Sbjct 1318 CITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKAFINETADMVK 1377
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VGG +G L KK L++VGP+ E LL+ AY++ N D ++ L+S
Sbjct 1378 AQGVCQVGGCYESTGGKLCKKVLNIVGPDARGHGNECYSLLERAYQHINKCDNVVTTLIS 1437
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N++ ++ +
Sbjct 1438 AGIFSVPTDVSLTYLLGVVTKNVILVSNNQDDFDVI 1473
Score = 46.2 bits (108), Expect = 0.010, Method: Composition-based stats.
Identities = 47/204 (23%), Positives = 79/204 (39%), Gaps = 21/204 (10%)
Query 1580 DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG 1639
D+ K++ + E +T P+D T + + E+ Y + T F
Sbjct 1054 DIEKVEDSILSELQTELNAPADKTYE-DVLAFDAIYSETLSAFYAVPSDETH---FKVC- 1108
Query 1640 GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV 1699
G S NC+L S L+ +Q L ++F +Q+ + +AG F ++ + K++
Sbjct 1109 GFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKLVKSAPKSI 1168
Query 1700 GEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLK 1757
G V + L S K N C CG L G++AV + G +
Sbjct 1169 ILPQGGYVADFAYFFLSQ---CSFKVHANWRCLKCGM-ELKLQGLDAVFFYGDV------ 1218
Query 1758 TGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG T L+ + +
Sbjct 1219 --VSHMCKCGNSMT--LLSADIPY 1238
>sp|P0C6X8|R1AB_CVM2 Replicase polyprotein 1ab OS=Murine coronavirus
(strain 2) OX=76344 GN=rep PE=3 SV=1
Length=7124
Score = 3641 bits (9442), Expect = 0.0, Method: Composition-based stats.
Identities = 1086/2925 (37%), Positives = 1600/2925 (55%), Gaps = 129/2925 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+V S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1543 KVASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1598
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
H+GK FF A DE L +Y + L KW G + K
Sbjct 1599 CSAIHKGKVFFQYSGLSAADLVAVTDAFGFDEPQLLKYYNMLGMC-KWPVVVCGNYFAFK 1657
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF+ QEA+ R+G F +L+LA + E D
Sbjct 1658 QSNNNCYINVACLMLQHLSLKFHKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1717
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ M +L+ A+L A VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1718 TDFMRVVLREADLSGATCDFEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLAKGYTIACT 1776
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG + + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1777 CG-NKLVHCTQLNVPFLICSNKPEGKKLPDDV-VAANIFTGG-SLGHYTHVKCKPKYQLY 1833
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D +++K+SE KG TD Y K T + K ++ LD V E P L YY + YY
Sbjct 1834 DACNVSKVSEAKGNFTDCLYLKNLKQTFSSKLTTFYLDDVKCVEYNPDLSQYYCESGKYY 1893
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + NFKL A+ N GF E +T +P G
Sbjct 1894 TKPIIKAQFRTFEKVEGVYTNFKLV--GHSIAEKFNAKLGFDCNSPFTEYKITEWPTATG 1951
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP++W ++ + + +P+ C ++ PVD
Sbjct 1952 DVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2010
Query 1999 SNSFE----VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDV----------- 2043
S + AV T + A ++V + ++ +V+ +
Sbjct 2011 SEPTDKGPVPAAVLVTGALSGAATAPGTAKEQKVCASDSVVDQVVSGFLSDLSGATVDVK 2070
Query 2044 --------KTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALG 2095
K +V +V++ KV + L D+ ++ + NELS +
Sbjct 2071 EVKLNGVKKPIKVEDSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWMANELSRLVN 2130
Query 2096 LKTIATHGIAAINSVPWS--KILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLL 2153
T+ + V W KI+ K L + K + +V Y + L
Sbjct 2131 SPTVREY-------VKWGMTKIVIPAKLVLLRDEKQEFVAPKVVKAKVIACYSAVKWFFL 2183
Query 2154 FQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTIAMW 2209
+ +T++++ T +A K LC A N +++ ++ F +A
Sbjct 2184 YCFSWIKFNTDNKVI--YTTEVAS---KLTFNLCCLAFKNALQTFNWNVVSRGFFLVATV 2238
Query 2210 LLLLSICLGSLI---------------CVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVT 2254
LL L + + V + + FG + C+ LY S
Sbjct 2239 FLLWFNFLYANVILSDFYLPNIGFFPTFVGQIVAWVKTTFGIFTLCD----LYQVSDVGY 2294
Query 2255 TMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYMLFT 2312
FC GS C +C SG D LD+Y A+ +Q + +++ L E V+ Y L+T
Sbjct 2295 RSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRVSFDYISLFKLVVELVIGYSLYT 2354
Query 2313 KFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FY L MQ+ + F+ + W F + + M P ++R YI + Y I
Sbjct 2355 VCFYPLFGLIGMQLLTTWLPEFFMLETMHWSARFFVFVANMLPAFTLLRFYIVVTAMYKI 2414
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
+ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNCL
Sbjct 2415 FCLCRHVMYGCSRPGCLFCYKRNRSVRVKCSTVVGGTLRYYDVMANGGTGFCAKHQWNCL 2474
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NC F G+TFI+ E A DLS + KRP+NPTD + Y+V V ++ L++++ GQ+ Y
Sbjct 2475 NCSAFGPGNTFITHEAAADLSKELKRPVNPTDSAYYLVTEVKQVGCSMRLFYERDGQRVY 2534
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +P+LL++
Sbjct 2535 DDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYRPMLLVE 2592
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
+ L++ VS MFD YVD+ V + L + V AH+ L +GV L+ V+ TF
Sbjct 2593 KKLITTANTGLSVSQTMFDLYVDSLLGVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDTF 2652
Query 2611 VSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACI 2669
+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG I
Sbjct 2653 IGCARRKCAIDSDVETKSITKSIMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVLI 2712
Query 2670 DCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN 2729
NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V
Sbjct 2713 QNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANVP 2772
Query 2730 VITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAI 2789
++TT SLKGG + S + + L+C + V + +MP + + D +K I
Sbjct 2773 ILTTPFSLKGGAVFSKVLQWLFVVNLICFI---VLWALMPTYAVHKSDMQLPLYASFKVI 2829
Query 2790 QDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGLP 2847
+GV RD+ TD CFANK FD W+ G Y+N ++CPVV A+I ++IG+ + +P
Sbjct 2830 DNGVLRDVTVTDACFANKFIQFDQWYESTFGLVYYRNSRACPVVVAVIDQDIGYTLFNVP 2889
Query 2848 GTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPV 2907
VLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P
Sbjct 2890 TKVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTPH 2948
Query 2908 PYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTC 2966
PYCY ++ + Y L P RY L + + I+FP EG VR+V T YCR G C
Sbjct 2949 PYCYTEGIMHNASLYDSLAPHVRYNLANSNGYIRFPEVVSEGIVRIVRTRSMTYCRVGLC 3008
Query 2967 ERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVA 3026
E +E G+C + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS VA
Sbjct 3009 EDAEEGVCFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSVA 3068
Query 3027 GGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFY 3086
G I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ FY
Sbjct 3069 GAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACFY 3128
Query 3087 LYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNG 3146
Y T YF +++S + HLQW M+ I+P W IYV + H W F+ +++
Sbjct 3129 FYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFSYC--RKLGTEV 3186
Query 3147 VTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREA 3206
+ TFEE +L TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +YREA
Sbjct 3187 RSDGTFEEMSLTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAAYREA 3244
Query 3207 ACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTT 3265
AC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM FP+ KVE C+V VT G
Sbjct 3245 ACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVFPTSKVEPCVVSVTYGNM 3304
Query 3266 TLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNC 3325
TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R + F V +G + L V+ + MQ
Sbjct 3305 TLNGLWLDDKVYCPRHVICSSADMTDPDYSNLLCRVISSDFCVMSGRMSLTVMSYQMQGS 3364
Query 3326 LLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSC 3385
LL L V NP TPKY F ++PG+TF+VLA YNG G + MR ++TIKGSFL GSC
Sbjct 3365 LLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGKSQGAFHVTMRSSYTIKGSFLCGSC 3424
Query 3386 GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVL 3445
GSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+NV+
Sbjct 3425 GSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTVNVV 3484
Query 3446 AWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMC 3505
AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ TG+ V +
Sbjct 3485 AWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVEQIL 3542
Query 3506 AALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFL 3565
AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K ++VKGT W+L + L
Sbjct 3543 AAIKRLY-SGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVVKGTCCWILASTL 3601
Query 3566 TSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVA 3625
I+ +W++F +V + L TL + + AMLLVKHKH +L +F++P L T+
Sbjct 3602 LFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLVKHKHLYLTMFIMPVLCTLF 3660
Query 3626 YFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYDDAAR 3683
Y N +V S+ WL ++ Y D V+Y L++ ++ +T R++ D
Sbjct 3661 YTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHDVFS 3719
Query 3684 RVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYY 3743
++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3720 VMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKWLAV 3775
Query 3744 PLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNS 3802
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RYMN+
Sbjct 3776 NVLYFTDVPQVKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKISVQELRYMNA 3835
Query 3803 QGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSS 3862
GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L + SSS
Sbjct 3836 NGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQSRLTDVKCVNVVLLNCLQHLHIASSS 3895
Query 3863 KLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLDNRA 3916
KLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ + +
Sbjct 3896 KLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVRDST 3955
Query 3917 TLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDAAMQ 3975
LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD A+
Sbjct 3956 VLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDRAVA 4015
Query 3976 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP 4035
RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA GCVP
Sbjct 4016 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMIRKLDNQALNSILDNAVKGCVP 4075
Query 4036 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDN 4095
LN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI++
Sbjct 4076 LNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQSIQDADGAVKQLNEIDV-- 4133
Query 4096 SPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSK 4153
N+ WPL++ A R N S+V LQNNEL P LR +G+ T YYN +
Sbjct 4134 --NITWPLVIAANRHNEVSSVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYNTTG 4189
Query 4154 GGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNN 4213
G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG N
Sbjct 4190 MGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKGCNT 4248
Query 4214 LNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVK 4273
L RG V+G+L++TVRLQAG ATE +NS + S CAF+VDP K Y DY+ GG P+TNCVK
Sbjct 4249 LARGWVVGTLSSTVRLQAGTATEYASNSAIRSLCAFSVDPKKTYLDYIQQGGAPVTNCVK 4308
Query 4274 MLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTC 4333
MLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P
Sbjct 4309 MLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVPLG- 4367
Query 4334 ANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
DPV + L + VC VCG W+ CSC + + FLN
Sbjct 4368 IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLN 4410
Score = 364 bits (935), Expect = 6e-99, Method: Composition-based stats.
Identities = 205/998 (21%), Positives = 341/998 (34%), Gaps = 165/998 (17%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPAYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDF 204
E D E+ N K+ A L + G ++D C G ++D+
Sbjct 217 FNVE---DACEEVHLNPKGKYSRKAYA-LLKGYRGVKSILFLDQYGCDYTGRLAKGLEDY 272
Query 205 LARAGKSMCTLSEQLDYIESKRGVYCCR-DHEHEIAWFTERSDKSYEH-QTPFEIKSAKK 262
CTL E + V+C D+E +AW +R ++ QT I+S
Sbjct 273 ------GDCTLEEMKELFP----VWCDSLDNEVVVAWHVDRDPRAVMRLQTLATIRSIGY 322
Query 263 FDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE--CNNMHLSTL 320
+ ++ V V +P R V + + + L
Sbjct 323 VGQPTEDL------VDGDVVVREPAHLLAANAIVKRLPRLVETMLYTDSSVTEFCYKTKL 376
Query 321 MKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDP---- 376
C + + C CG + G++P N + CP C
Sbjct 377 CDCGFITQFGYVDC---------CG------DACDFRGWVPGNMMDGFLCPGCSKSYMPW 421
Query 377 --EIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSG 434
E + T + +G V VP SA S
Sbjct 422 ELEAQSSGVIPKGGVLFTQSTDTVNRESFKLYGHAV-------------VPFGSAVYWSP 468
Query 435 HTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSL 494
+ G+ L ++ D V A + ++
Sbjct 469 YPGMW--------------LPVIWSSVKSYADLTYTGVVGC---------KAIVQETDAI 505
Query 495 DYKSFKTIVES-CGNYKVTKGKPVKGA------WNIGQQRSVLTPLCGFPSQAAGVIRSI 547
+ V+ CGN + + N G +L + F + A
Sbjct 506 CRSLYMDYVQHKCGNLEQRAILGLDDVYHRQLLVNRGDYSLLLENVDLFVKRRAEFACKF 565
Query 548 FARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAY 600
+ D +LDG+ +S L+ + MV S +T+ + MA
Sbjct 566 A---------TCGD--GLVPLLLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMAL 614
Query 601 VTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFL 652
+ V+ ++++ + G V +R I EW + + W + L
Sbjct 615 LFMHDVKVATKYVKKVTGKLAVRFKALGVAVVRKITEWFDLAVDTAAS--AAGWLCYQ-L 671
Query 653 ITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVF 709
+ G+F + G I SD + + VK F+D ++ ID ++++ G + V
Sbjct 672 VNGLFAVANGGITFLSD-VPELVKNFVDKFKVFFKVLIDSMSVSVLSGLTVVKTASNRVC 730
Query 710 IAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALE 767
+A K + K +MP+ E T L G+ V+ + V + L +
Sbjct 731 LAGCKVY---EVVQKRLSAYVMPVGCN-EATCLVGEIEPAVVEDDVVDVVKAPLTYQGCC 786
Query 768 TPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRLKGGAPIKGV 824
P SF +V + L + + D+ + G+L F G K V
Sbjct 787 KPPTSFEKICVV------DKLYMAKCGDQFYPVVVDNDTIGVLDQCWRFPCAG----KKV 836
Query 825 TFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKT 883
F + V E+ + ++I F LD D VL++ CS + V+ + E VV +AV T
Sbjct 837 EFNDKPKVKEIPSTRKIKINFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVEST 896
Query 884 LQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEE 940
L P + + T + L+ + YLFD+ GEE + +MYCSF PD+E+ C
Sbjct 897 LSPCKEHDVIGTKVCALLNRLAEDYVYLFDEGGEEVIAPKMYCSFSAPDDED-----CVA 951
Query 941 EEIDETCEHEYGTEDDYQGLPL----EFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPE 996
++ + E++ DD L E G + V V E + D E +IE +
Sbjct 952 ADVVDADENQGDDADDSAALVTDTQEEDGVAKGQVGVAESDAR---LDQVEAFDIEKVED 1008
Query 997 PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMV 1034
P E + T + I EA SA V
Sbjct 1009 PILNELSAELNAPADKTYEDVLAFDAIYSEALSAFYAV 1046
Score = 139 bits (351), Expect = 6e-31, Method: Composition-based stats.
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + VIVN AN + HG GVAGA+ KA + KE+ D +K
Sbjct 1266 CITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKSFIKETADMVK 1325
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VG +G NL K L++VGP+ + L+ AY++ N D ++ L+S
Sbjct 1326 NQGVCQVGECYESTGGNLCKTVLNIVGPDARGHGKQCYSFLERAYQHINKCDDVVTTLIS 1385
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N+K ++ +
Sbjct 1386 AGIFSVPTDVSLTYLIGVVTKNVILVSNNKDDFDVI 1421
Score = 42.4 bits (98), Expect = 0.13, Method: Composition-based stats.
Identities = 45/238 (19%), Positives = 81/238 (34%), Gaps = 26/238 (11%)
Query 1551 VDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFE 1610
D V S Q + D+ K++ + +E P+D T E
Sbjct 978 EDGVAKGQVGVAESDARLDQV-----EAFDIEKVEDPILNELSAELNAPADKT--YEDVL 1030
Query 1611 YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAP 1670
+ + L + + +K G S NC+L S L+ +Q L ++F
Sbjct 1031 AFDAIYSEALSAFYAVPGDETHFKVC---GFYSPAIERTNCWLRSTLIVMQSLPLEFKDL 1087
Query 1671 ALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQHANLESAKRVLNVV 1728
+Q+ + ++ F ++ K++ G V + L S K N
Sbjct 1088 EMQKLWLSYKSSYNKEFVDKLVKSVPKSIILPQGGYVADFAYFFLSQ---CSFKAYANWR 1144
Query 1729 CKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
C C L G++A+ + G + VS C CG T L+ + + +
Sbjct 1145 CLKCDM-DLKLQGLDAMFFYGDV--------VSHVCKCGTGMT--LLSADIPYTLHFG 1191
>sp|P0C6U9|R1A_CVM2 Replicase polyprotein 1a OS=Murine coronavirus
(strain 2) OX=76344 GN=1a PE=3 SV=1
Length=4416
Score = 3641 bits (9441), Expect = 0.0, Method: Composition-based stats.
Identities = 1089/2929 (37%), Positives = 1603/2929 (55%), Gaps = 129/2929 (4%)
Query 1526 EVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIK 1585
+V S+ ++++LL + V TVD N + V +G+ G + DG +VTK++
Sbjct 1543 KVASVSQIRALL----ANKVDVLCTVDGVNFRSCCVAEGEVFGKTLGSVFCDGINVTKVR 1598
Query 1586 PHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIK 1645
H+GK FF A DE L +Y + L KW G + K
Sbjct 1599 CSAIHKGKVFFQYSGLSAADLVAVTDAFGFDEPQLLKYYNMLGMC-KWPVVVCGNYFAFK 1657
Query 1646 WADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDV 1705
++NNCY++ L LQ L +KF+ QEA+ R+G F +L+LA + E D
Sbjct 1658 QSNNNCYINVACLMLQHLSLKFHKWQWQEAWNEFRSGKPLRFVSLVLAKGSFKFNEPSDS 1717
Query 1706 RETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCV 1765
+ M +L+ A+L A VCK CG K GV+AVM+ GTL +L G +I C
Sbjct 1718 TDFMRVVLREADLSGATCDFEFVCK-CGVKQEQRKGVDAVMHFGTLDKGDLAKGYTIACT 1776
Query 1766 CGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRI 1825
CG + + Q F++ S P KL + AN +TG GHYTH+ K
Sbjct 1777 CG-NKLVHCTQLNVPFLICSNKPEGKKLPDDV-VAANIFTGG-SLGHYTHVKCKPKYQLY 1833
Query 1826 DGAHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYY 1884
D +++K+SE KG TD Y K T + K ++ LD V E P L YY + YY
Sbjct 1834 DACNVSKVSEAKGNFTDCLYLKNLKQTFSSKLTTFYLDDVKCVEYNPDLSQYYCESGKYY 1893
Query 1885 TEQPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNG 1942
T+ I T + NFKL A+ N GF E +T +P G
Sbjct 1894 TKPIIKAQFRTFEKVEGVYTNFKLV--GHSIAEKFNAKLGFDCNSPFTEYKITEWPTATG 1951
Query 1943 DVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF----KPNTWCLRCLWSTKPVDT 1998
DVV Y + + G KP++W ++ + + +P+ C ++ PVD
Sbjct 1952 DVVLASDDLYVSRYSGGCVTFGKPVIWLGHEEASLKSLTYFNRPSVVCEN-KFNVLPVDV 2010
Query 1999 SNSFE----VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDV----------- 2043
S + AV T + A ++V + ++ +V+ +
Sbjct 2011 SEPTDKGPVPAAVLVTGALSGAATAPGTAKEQKVCASDSVVDQVVSGFLSDLSGATVDVK 2070
Query 2044 --------KTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALG 2095
K +V +V++ KV + L D+ ++ + NELS +
Sbjct 2071 EVKLNGVKKPIKVEDSVVVNDPTSETKVVKSLSIVDVYDMFLTGCRYVVWMANELSRLVN 2130
Query 2096 LKTIATHGIAAINSVPWS--KILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLL 2153
T+ + V W KI+ K L + K + +V Y + L
Sbjct 2131 SPTVREY-------VKWGMTKIVIPAKLVLLRDEKQEFVAPKVVKAKVIACYSAVKWFFL 2183
Query 2154 FQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFS----KLFTIAMW 2209
+ +T++++ T +A K LC A N +++ ++ F +A
Sbjct 2184 YCFSWIKFNTDNKVI--YTTEVAS---KLTFNLCCLAFKNALQTFNWNVVSRGFFLVATV 2238
Query 2210 LLLLSICLGSLI---------------CVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVT 2254
LL L + + V + + FG + C+ LY S
Sbjct 2239 FLLWFNFLYANVILSDFYLPNIGFFPTFVGQIVAWVKTTFGIFTLCD----LYQVSDVGY 2294
Query 2255 TMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYK--LDLTILGLAAEWVLAYMLFT 2312
FC GS C +C SG D LD+Y A+ +Q + +++ L E V+ Y L+T
Sbjct 2295 RSSFCNGSMVCELCFSGFDMLDNYDAINVVQHVVDRRVSFDYISLFKLVVELVIGYSLYT 2354
Query 2313 KFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVSAMVRMYIFFASFYYI 2370
FY L MQ+ + F+ + W F + + M P ++R YI + Y I
Sbjct 2355 VCFYPLFGLIGMQLLTTWLPEFFMLETMHWSARFFVFVANMLPAFTLLRFYIVVTAMYKI 2414
Query 2371 WKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCL 2430
+ H+M GC+ C+ CYKRNR+ RV+C+T+V G R + V ANGG GFC H WNCL
Sbjct 2415 FCLCRHVMYGCSRPGCLFCYKRNRSVRVKCSTVVGGTLRYYDVMANGGTGFCAKHQWNCL 2474
Query 2431 NCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTY 2490
NC F G+TFI+ E A DLS + KRP+NPTD + Y+V V ++ L++++ GQ+ Y
Sbjct 2475 NCSAFGPGNTFITHEAAADLSKELKRPVNPTDSAYYLVTEVKQVGCSMRLFYERDGQRVY 2534
Query 2491 ERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLD 2550
+ S FV+++ L + KG +V+V + ++ D++ +A+V+Y+Q + +P+LL++
Sbjct 2535 DDVSASLFVDMNGLLHSKVKGVPETHVVVVENEA--DKAGFLNAAVFYAQSLYRPMLLVE 2592
Query 2551 QALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTF 2610
+ L++ VS MFD YVD+ V + L + V AH+ L +GV L+ V+ TF
Sbjct 2593 KKLITTANTGLSVSQTMFDLYVDSLLGVLDVDRKSLTSFVNAAHNSLKEGVQLEQVMDTF 2652
Query 2611 VSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTPRDLGACI 2669
+ AR+ +D+DV+TK + + + + ++ ++ T +SCNN + TY K + + DLG I
Sbjct 2653 IGCARRKCAIDSDVETKSITKSIMSAVNAGVDFTDESCNNLVPTYVKSDTIVAADLGVLI 2712
Query 2670 DCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVN 2729
NA+H+ A VAK+ NV+ IW+V + LS L+ ++R A K + +LT V
Sbjct 2713 QNNAKHVQANVAKAANVACIWSVDAFNQLSADLQHRLRKACSKTGLKIKLTYNKQEANVP 2772
Query 2730 VITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAI 2789
++TT SLKGG + S + + L+C + V + +MP + + D +K I
Sbjct 2773 ILTTPFSLKGGAVFSKVLQWLFVVNLICFI---VLWALMPTYAVHKSDMQLPLYASFKVI 2829
Query 2790 QDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVAAIITREIGFIVPGLP 2847
+GV RD+ TD CFANK FD W+ G Y+N ++CPVV A+I ++IG+ + +P
Sbjct 2830 DNGVLRDVTVTDACFANKFIQFDQWYESTFGLVYYRNSRACPVVVAVIDQDIGYTLFNVP 2889
Query 2848 GTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPV 2907
VLR LHF+ F+ CYTP I Y +F S CVL++ CT+ A G P
Sbjct 2890 TKVLR-YGFHVLHFITHAFATDSVQCYTPHMQIPYDNFYASGCVLSSLCTMLAHADGTPH 2948
Query 2908 PYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVRVVTTFDAEYCRHGTC 2966
PYCY ++ + Y L P RY L + + I+FP EG VR+V T YCR G C
Sbjct 2949 PYCYTEGIMHNASLYDSLAPHVRYNLANSNGYIRFPEVVSEGIVRIVRTRSMTYCRVGLC 3008
Query 2967 ERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVA 3026
E +E G+C + + WVLNN +YRA+ G FCG +A +LI + LV+P+ ++AS VA
Sbjct 3009 EDAEEGVCFNFNSSWVLNNPYYRAMPGTFCGRNAFDLIHQVLGGLVRPIDFFALTASSVA 3068
Query 3027 GGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFY 3086
G I+AI+V A YY +K +R FG+Y VV N +++ ++F +L + Y L +Y+ FY
Sbjct 3069 GAILAIIVVLAFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFVFQVYPTLSCLYACFY 3128
Query 3087 LYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNG 3146
Y T YF +++S + HLQW M+ I+P W IYV + H W F+ +++
Sbjct 3129 FYTTLYFPSEISVVMHLQWLVMYGAIMPLWFCIIYVAVVVSNHALWLFSYC--RKLGTEV 3186
Query 3147 VTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREA 3206
+ TFEE +L TF++ KE Y KL++ + +NRYL+LYNKY+YFSG +DT +YREA
Sbjct 3187 RSDGTFEEMSLTTFMITKESYCKLKNS--VSDVAFNRYLSLYNKYRYFSGKMDTAAYREA 3244
Query 3207 ACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTT 3265
AC LAKA+ F+ N+G DVLYQPP S+T++ LQSG KM FP+ KVE C+V VT G
Sbjct 3245 ACSQLAKAMETFNHNNGNDVLYQPPTASVTTSFLQSGIVKMVFPTSKVEPCVVSVTYGNM 3304
Query 3266 TLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNC 3325
TLNGLWLDD VYCPRHVIC++ DM +P+Y +LL R + F V +G + L V+ + MQ
Sbjct 3305 TLNGLWLDDKVYCPRHVICSSADMTDPDYSNLLCRVISSDFCVMSGRMSLTVMSYQMQGS 3364
Query 3326 LLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSC 3385
LL L V NP TPKY F ++PG+TF+VLA YNG G + MR ++TIKGSFL GSC
Sbjct 3365 LLVLTVTLQNPNTPKYSFGVVKPGETFTVLAAYNGKSQGAFHVTMRSSYTIKGSFLCGSC 3424
Query 3386 GSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVL 3445
GSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q Q D T T+NV+
Sbjct 3425 GSVGYVLTGDSVRFVYMHQLELSTGCHTGTDFSGNFYGPYRDAQVVQLPVQDYTQTVNVV 3484
Query 3446 AWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMC 3505
AWLYAA++N WF+ + +L +FN+ AM + + D V L L++ TG+ V +
Sbjct 3485 AWLYAAILNRCNWFVQSDSCSLEEFNVWAMTNGFSSIKADLV--LDALASMTGVTVEQIL 3542
Query 3506 AALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFL 3565
AA+K L +G G+ ILGS +LEDE TP DV +Q +GV Q K ++VKGT W+L + L
Sbjct 3543 AAIKRLY-SGFQGKQILGSCVLEDELTPSDVYQQLAGVKLQSKRTRVVKGTCCWILASTL 3601
Query 3566 TSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVA 3625
I+ +W++F +V + L TL + + AMLLVKHKH +L +F++P L T+
Sbjct 3602 LFCSIISAFVKWTMFMYVTTH-MLGVTLCALCFVSFAMLLVKHKHLYLTMFIMPVLCTLF 3660
Query 3626 YFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL-LILMTARTVYDDAAR 3683
Y N +V S+ WL ++ Y D V+Y L++ ++ +T R++ D
Sbjct 3661 YTNYLVVYKQSFRGLAYAWLSHFVPAVD-YTYMDEVLYGVVLLVAMVFVTMRSINHDVFS 3719
Query 3684 RVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYY 3743
++ + +++LV Y+G L++ + ++ + S+ Y+ TT++ LA A V
Sbjct 3720 VMFLVGRLVSLVSMWYFGANLEEEVLLF--LTSLFGTYTW--TTMLSLATAKVIAKWLAV 3775
Query 3744 PLLFITG-NTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNS 3802
+L+ T ++ ++L Y +GY CCCY+G+ LLN FR+ LGVY+Y +S QE RYMN+
Sbjct 3776 NVLYFTDVPQVKLVLLSYLCIGYVCCCYWGVLSLLNSIFRMPLGVYNYKISVQELRYMNA 3835
Query 3803 QGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSS 3862
GL PP++S +A LN KLLGIGG P I+V+ +QS+++DVKC +VVLL+ LQ L + SSS
Sbjct 3836 NGLRPPRNSFEALVLNFKLLGIGGVPVIEVSQIQSRLTDVKCVNVVLLNCLQHLHIASSS 3895
Query 3863 KLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEEMLDNRA 3916
KLW C LHN+IL D + AF+K+ LL VL + AVD I + ++ + +
Sbjct 3896 KLWQYCSTLHNEILATSDLSVAFDKLAQLLVVLFANPAAVDSKCLASIEEVSDDYVRDST 3955
Query 3917 TLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS-EVVLKKLKKSLNVAKSEFDRDAAMQ 3975
LQA+ SEF ++ S+ Y A++ ++A A+G + + +K+L+K+ N+AKS ++RD A+
Sbjct 3956 VLQALQSEFVNMASFVEYELAKKNLDEAKASGSANQQQIKQLEKACNIAKSAYERDRAVA 4015
Query 3976 RKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVP 4035
RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN ALN+I++NA GCVP
Sbjct 4016 RKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMIRKLDNQALNSILDNAVKGCVP 4075
Query 4036 LNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDN 4095
LN IP T+ L ++VPD + D TYA +W IQ + DAD + QL+EI++
Sbjct 4076 LNAIPSLTSNTLTIIVPDKQVFDQVVDNVYVTYAGNVWHIQSIQDADGAVKQLNEIDV-- 4133
Query 4096 SPNLAWPLIVTALRAN--SAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSK 4153
N+ WPL++ A R N S+V LQNNEL P LR +G+ T YYN +
Sbjct 4134 --NITWPLVIAANRHNEVSSVVLQNNELMPQKLRTQVVNSGSDMNCNTPTQ--CYYNTTG 4189
Query 4154 GGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNN 4213
G+ V A+LSD LK+ + K DG + EL+PPC+F KG K+KYLYF+KG N
Sbjct 4190 MGKIVYAILSDCDGLKYTKIVKEDGNCVV-LELDPPCKFSVQDVKGLKIKYLYFVKGCNT 4248
Query 4214 LNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVK 4273
L RG V+G+L++TVRLQAG ATE +NS + S CAF+VDP K Y DY+ GG P+TNCVK
Sbjct 4249 LARGWVVGTLSSTVRLQAGTATEYASNSAIRSLCAFSVDPKKTYLDYIQQGGAPVTNCVK 4308
Query 4274 MLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTC 4333
MLC H GTG AIT+ PEA +Q+S+GGAS C+YCR ++HP+ G C L+GK+VQ+P
Sbjct 4309 MLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHPDVDGLCKLRGKFVQVPLG- 4367
Query 4334 ANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFAV 4382
DPV + L + VC VCG W+ CSC + + FLNGF V
Sbjct 4368 IKDPVSYVLTHDVCQVCGFWRDGSCSCVGTGSQFQ--SKDTNFLNGFGV 4414
Score = 363 bits (932), Expect = 1e-98, Method: Composition-based stats.
Identities = 205/998 (21%), Positives = 341/998 (34%), Gaps = 165/998 (17%)
Query 93 DGIQYGRSGITLGVLVPHVGETPIAYR-----NVLLRKNGNKGA---GGHSYGIDLKSYD 144
DG+ G +G +G VP A + ++LLRK GNKG+ G + + YD
Sbjct 158 DGVCLG-NGRFIGWFVPVTAIPAYAKQWLQPWSILLRKGGNKGSVTSGHFRRAVTMPVYD 216
Query 145 LGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDF 204
E D E+ N K+ A L + G ++D C G ++D+
Sbjct 217 FNVE---DACEEVHLNPKGKYSRKAYA-LLKGYRGVKSILFLDQYGCDYTGRLAKGLEDY 272
Query 205 LARAGKSMCTLSEQLDYIESKRGVYCCR-DHEHEIAWFTERSDKSYEH-QTPFEIKSAKK 262
CTL E + V+C D+E +AW +R ++ QT I+S
Sbjct 273 ------GDCTLEEMKELFP----VWCDSLDNEVVVAWHVDRDPRAVMRLQTLATIRSIGY 322
Query 263 FDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQE--CNNMHLSTL 320
+ ++ V V +P R V + + + L
Sbjct 323 VGQPTEDL------VDGDVVVREPAHLLAANAIVKRLPRLVETMLYTDSSVTEFCYKTKL 376
Query 321 MKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDP---- 376
C + + C CG + G++P N + CP C
Sbjct 377 CDCGFITQFGYVDC---------CG------DACDFRGWVPGNMMDGFLCPGCSKSYMPW 421
Query 377 --EIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSG 434
E + T + +G V VP SA S
Sbjct 422 ELEAQSSGVIPKGGVLFTQSTDTVNRESFKLYGHAV-------------VPFGSAVYWSP 468
Query 435 HTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSL 494
+ G+ L ++ D V A + ++
Sbjct 469 YPGMW--------------LPVIWSSVKSYADLTYTGVVGC---------KAIVQETDAI 505
Query 495 DYKSFKTIVES-CGNYKVTKGKPVKGA------WNIGQQRSVLTPLCGFPSQAAGVIRSI 547
+ V+ CGN + + N G +L + F + A
Sbjct 506 CRSLYMDYVQHKCGNLEQRAILGLDDVYHRQLLVNRGDYSLLLENVDLFVKRRAEFACKF 565
Query 548 FARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDA-------MVYTSDLLTNSVIIMAY 600
+ D +LDG+ +S L+ + MV S +T+ + MA
Sbjct 566 A---------TCGD--GLVPLLLDGLVPRSYYLIKSGQAFTSMMVNFSHEVTDMCMDMAL 614
Query 601 VTGGLVQQTSQWLSNLLGTT--------VEKLRPIFEWIEAKLSAGVEFLKDAWEILKFL 652
+ V+ ++++ + G V +R I EW + + W + L
Sbjct 615 LFMHDVKVATKYVKKVTGKLAVRFKALGVAVVRKITEWFDLAVDTAAS--AAGWLCYQ-L 671
Query 653 ITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIA---GAKLRSLNLGEVF 709
+ G+F + G I SD + + VK F+D ++ ID ++++ G + V
Sbjct 672 VNGLFAVANGGITFLSD-VPELVKNFVDKFKVFFKVLIDSMSVSVLSGLTVVKTASNRVC 730
Query 710 IAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGEL--EALE 767
+A K + K +MP+ E T L G+ V+ + V + L +
Sbjct 731 LAGCKVY---EVVQKRLSAYVMPVGCN-EATCLVGEIEPAVVEDDVVDVVKAPLTYQGCC 786
Query 768 TPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSP---GLLATNNVFRLKGGAPIKGV 824
P SF +V + L + + D+ + G+L F G K V
Sbjct 787 KPPTSFEKICVV------DKLYMAKCGDQFYPVVVDNDTIGVLDQCWRFPCAG----KKV 836
Query 825 TFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKT 883
F + V E+ + ++I F LD D VL++ CS + V+ + E VV +AV T
Sbjct 837 EFNDKPKVKEIPSTRKIKINFALDATFDSVLSKACSEFEVDKDVTLDELLDVVLDAVEST 896
Query 884 LQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEE 940
L P + + T + L+ + YLFD+ GEE + +MYCSF PD+E+ C
Sbjct 897 LSPCKEHDVIGTKVCALLNRLAEDYVYLFDEGGEEVIAPKMYCSFSAPDDED-----CVA 951
Query 941 EEIDETCEHEYGTEDDYQGLPL----EFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPE 996
++ + E++ DD L E G + V V E + D E +IE +
Sbjct 952 ADVVDADENQGDDADDSAALVTDTQEEDGVAKGQVGVAESDAR---LDQVEAFDIEKVED 1008
Query 997 PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMV 1034
P E + T + I EA SA V
Sbjct 1009 PILNELSAELNAPADKTYEDVLAFDAIYSEALSAFYAV 1046
Score = 139 bits (350), Expect = 7e-31, Method: Composition-based stats.
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV D++K + VIVN AN + HG GVAGA+ KA + KE+ D +K
Sbjct 1266 CITPNVCFVKGDVIKVLRRVGAEVIVNPANGRMAHGAGVAGAIAKAAGKSFIKETADMVK 1325
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQDILLAPLLS 1128
G VG +G NL K L++VGP+ + L+ AY++ N D ++ L+S
Sbjct 1326 NQGVCQVGECYESTGGNLCKTVLNIVGPDARGHGKQCYSFLERAYQHINKCDDVVTTLIS 1385
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + V V + N+K ++ +
Sbjct 1386 AGIFSVPTDVSLTYLIGVVTKNVILVSNNKDDFDVI 1421
Score = 42.4 bits (98), Expect = 0.15, Method: Composition-based stats.
Identities = 45/238 (19%), Positives = 81/238 (34%), Gaps = 26/238 (11%)
Query 1551 VDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFE 1610
D V S Q + D+ K++ + +E P+D T E
Sbjct 978 EDGVAKGQVGVAESDARLDQV-----EAFDIEKVEDPILNELSAELNAPADKT--YEDVL 1030
Query 1611 YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAP 1670
+ + L + + +K G S NC+L S L+ +Q L ++F
Sbjct 1031 AFDAIYSEALSAFYAVPGDETHFKVC---GFYSPAIERTNCWLRSTLIVMQSLPLEFKDL 1087
Query 1671 ALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQHANLESAKRVLNVV 1728
+Q+ + ++ F ++ K++ G V + L S K N
Sbjct 1088 EMQKLWLSYKSSYNKEFVDKLVKSVPKSIILPQGGYVADFAYFFLSQ---CSFKAYANWR 1144
Query 1729 CKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSA 1786
C C L G++A+ + G + VS C CG T L+ + + +
Sbjct 1145 CLKCDM-DLKLQGLDAMFFYGDV--------VSHVCKCGTGMT--LLSADIPYTLHFG 1191
>sp|P0C6T9|R1A_CVBLU Replicase polyprotein 1a OS=Bovine coronavirus
(strain 98TXSF-110-LUN) OX=233264 GN=1a PE=3 SV=1
Length=4383
Score = 3506 bits (9090), Expect = 0.0, Method: Composition-based stats.
Identities = 1078/2895 (37%), Positives = 1613/2895 (56%), Gaps = 105/2895 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + +G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGENFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES S+E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N+LS+A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRYVVRTANDLSMAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + ++ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKPGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++++ GQ+TY+ S FV+ NL + KG ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFLLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYTSYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F +R+ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFAYC--RRLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLNGFAV 4382
+QS D + FLNGF V
Sbjct 4368 VQSKD-TNFLNGFGV 4381
Score = 306 bits (784), Expect = 2e-81, Method: Composition-based stats.
Identities = 183/972 (19%), Positives = 332/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKICHAVVSKSKELLD-------VSLDSLSAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVVDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V + F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVEMSDFADLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 177 bits (450), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.006, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6T8|R1A_CVBEN Replicase polyprotein 1a OS=Bovine coronavirus
(strain 98TXSF-110-ENT) OX=233262 GN=1a PE=3 SV=1
Length=4383
Score = 3506 bits (9090), Expect = 0.0, Method: Composition-based stats.
Identities = 1078/2895 (37%), Positives = 1612/2895 (56%), Gaps = 105/2895 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYNPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES S+E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N LS+A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRYVVRTANALSMAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + ++ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFILFRHVAYGCSKPGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++++ GQ+TY+ S FV+ NL + KG ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFLLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F +R+ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFAYC--RRLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLNGFAV 4382
+QS D + FLNGF V
Sbjct 4368 VQSKD-TNFLNGFGV 4381
Score = 307 bits (785), Expect = 1e-81, Method: Composition-based stats.
Identities = 183/972 (19%), Positives = 332/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKICHAVVSKSKELLD-------VSLDSLSAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V + F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVEMSDFADLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 177 bits (450), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.006, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6W8|R1AB_CVBLU Replicase polyprotein 1ab OS=Bovine coronavirus
(strain 98TXSF-110-LUN) OX=233264 GN=rep PE=3 SV=1
Length=7094
Score = 3502 bits (9081), Expect = 0.0, Method: Composition-based stats.
Identities = 1075/2891 (37%), Positives = 1610/2891 (56%), Gaps = 105/2891 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + +G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGENFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES S+E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N+LS+A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRYVVRTANDLSMAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + ++ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKPGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++++ GQ+TY+ S FV+ NL + KG ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFLLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYTSYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F +R+ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFAYC--RRLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLN 4378
+QS D + FLN
Sbjct 4368 VQSKD-TNFLN 4377
Score = 307 bits (786), Expect = 1e-81, Method: Composition-based stats.
Identities = 183/972 (19%), Positives = 332/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKICHAVVSKSKELLD-------VSLDSLSAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVVDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V + F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVEMSDFADLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 178 bits (451), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.006, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6W7|R1AB_CVBEN Replicase polyprotein 1ab OS=Bovine coronavirus
(strain 98TXSF-110-ENT) OX=233262 GN=rep PE=3 SV=1
Length=7094
Score = 3502 bits (9081), Expect = 0.0, Method: Composition-based stats.
Identities = 1075/2891 (37%), Positives = 1609/2891 (56%), Gaps = 105/2891 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYNPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTICDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES S+E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKESKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N LS+A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRYVVRTANALSMAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + ++ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKSTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFILFRHVAYGCSKPGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++++ GQ+TY+ S FV+ NL + KG ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYERDGQRTYDDVNASLFVDYSNLLHSKVKGVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFLLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ +++G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDLGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTEGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F +R+ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFAYC--RRLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSVG+ + DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVLMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ AMLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLAMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ D + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINHDLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRHNEVSATVLQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A +Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTNQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLN 4378
+QS D + FLN
Sbjct 4368 VQSKD-TNFLN 4377
Score = 307 bits (787), Expect = 1e-81, Method: Composition-based stats.
Identities = 183/972 (19%), Positives = 332/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKICHAVVSKSKELLD-------VSLDSLSAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RRVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE +S++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLASKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V + F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVEMSDFADLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 178 bits (451), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAEKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.006, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6U0|R1A_CVBM Replicase polyprotein 1a OS=Bovine coronavirus
(strain Mebus) OX=11132 GN=1a PE=3 SV=1
Length=4383
Score = 3479 bits (9020), Expect = 0.0, Method: Composition-based stats.
Identities = 1074/2895 (37%), Positives = 1604/2895 (55%), Gaps = 105/2895 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES +E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKEPKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N LS A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + N+ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDAMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++D+ GQ+TY+ S FV+ NL + K ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMPYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F+ +++ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFSYC--RQLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWL D VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLGDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSV + I DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVVYVIMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKHL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ MLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLTMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINQYLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLHEI----SDDCNWPLVIIANRHNEVSATALQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLNGFAV 4382
+QS D + FLNGF V
Sbjct 4368 VQSKD-TNFLNGFGV 4381
Score = 304 bits (779), Expect = 8e-81, Method: Composition-based stats.
Identities = 181/972 (19%), Positives = 328/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A + + +LD +D++ L + ++ +A Q
Sbjct 603 DYAGKICHAVVSKSKELLD-------VSLDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP K ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKTKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RCVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE + ++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVN--QFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVQMSDFVDLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 178 bits (451), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T + QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.007, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6U4|R1A_CVHN2 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N2) OX=443240 GN=1a PE=3 SV=1
Length=4441
Score = 3476 bits (9014), Expect = 0.0, Method: Composition-based stats.
Identities = 1057/2942 (36%), Positives = 1588/2942 (54%), Gaps = 112/2942 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1563 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1618
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1619 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1678
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1679 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1737
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1738 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1797
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1798 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1855
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1856 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1913
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1914 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1972
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 1973 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2030
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2031 KGCETFGKPVIWLCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2075
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2076 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2135
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2136 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2194
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2195 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2248
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2249 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2308
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2309 CDFYSKLGVG----FTSHFCNGSFICELCYSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2364
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2365 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2424
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2425 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2484
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2485 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2544
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2545 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2602
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2603 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2662
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2663 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2722
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2723 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDTFNQLTADLQHKLKKACVKTG 2782
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2783 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2839
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2840 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVV 2899
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2900 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2958
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2959 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3018
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3019 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3078
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3079 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3138
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3139 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3198
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3199 WLFSYC--RKIGVNVCNDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3254
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3255 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3314
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3315 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3374
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3375 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3434
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3435 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3494
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3495 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3552
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3553 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3611
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3612 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3670
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3671 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGLTYVWLSYFVPAVNFTYVYEVFYGCILCVFA 3730
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3731 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3788
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3789 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3847
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3848 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3907
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+S+LW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3908 LNCLQHLHVASNSRLWQYCSILHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKCLAS 3967
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3968 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4027
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4028 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4087
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPLN IP A L +++PD + D YA ++W IQ V DAD
Sbjct 4088 NSILDNAVKGCVPLNAIPALAANTLTIIIPDKQVFDKVVDNVYVAYAGSVWHIQTVQDAD 4147
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4148 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDMNCN 4203
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4204 IPTQ--CYYNNGSSGRIVYAVLSDVDGLKYTKIIKDDGNCVV-LELDPPCKFSIQDVKGL 4260
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4261 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4320
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4321 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGLC 4380
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLNGF
Sbjct 4381 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SGVAVQSKDL-NFLNGF 4437
Query 4381 AV 4382
V
Sbjct 4438 GV 4439
Score = 282 bits (722), Expect = 4e-74, Method: Composition-based stats.
Identities = 150/900 (17%), Positives = 290/900 (32%), Gaps = 149/900 (17%)
Query 141 KSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDC 200
+D D D + K+ A L R+ G +VD C G DC
Sbjct 185 FKFDDYDFSVEDAYAEVHAEPKGKYSQKAYA-LLRQYRGIKPVLFVDQYGCDYSGKLADC 243
Query 201 IKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKS 259
A S+ + ++ + +AW R + QT I
Sbjct 244 ---LQAYGHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICG 294
Query 260 AKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLST 319
K + + V ++ K M V +++
Sbjct 295 IKYVAQPTEDVVDGAVVIREPVHLLSADAIVLKLPSLM----KVMTHMDDFSIKSIYNVD 350
Query 320 LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIG 379
L C + + C +N G + + + C D
Sbjct 351 LCDCGFVMQYGYV----------DCFNDNCDFYGWVSGNMM--DGFSCPLCCTVYDSSEV 398
Query 380 PEHS---VADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHT 436
S + + T +G V G YW PR
Sbjct 399 KAQSSGVIPENPVLFTNSTDTVNPDSFNLYGYSV-TPFGSC---IYWSPRP--------- 445
Query 437 GITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDY 496
G+ +++ + ++ + + S +T
Sbjct 446 GLWIPIIKSSVKSYDDL----------------------VYSGVVGCKSIVKETALITHA 483
Query 497 KSFKTIVESCGNYKVTKGKPVKGAW------NIGQQRSVLTPLCGFPSQAAGVIR--SIF 548
+ CGN + V +W N G +L + F + A ++
Sbjct 484 LYLDYVQCKCGNLEQNHILGVNNSWCRQLLLNRGDYNMLLKNIDLFVKRRADFACKFAVC 543
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYT-------SDLLTNSVIIMAYV 601
+LDG+ +S L+ + ++ S +++ + M +
Sbjct 544 GDGF-------------VPFLLDGLIPRSYYLIQSGIFFTSLMSQFSQEVSDMCLKMCIL 590
Query 602 TGGLVQQTSQWLSNLLGTTVEK--------LRPIFEWIEAKLSAGVEFLKDAWEILKFLI 653
V + ++ + + V + + + W L A W + + L+
Sbjct 591 FMDRVSVATFYIEHYVNRLVTQFKLLGTTLVNKMVNWFNTMLDASAP--ATGWLLYQ-LL 647
Query 654 TGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----LRSLN----- 704
G+F + + + I D K ++ ++ ++ VT+ K L+++N
Sbjct 648 NGLFVVSQANFNFVA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCI 706
Query 705 LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGEL 763
+G F S GL ++P A +++ F EG +E V++++ +
Sbjct 707 VGNKFYNVSTGLI---------PGFVLPCNAQEQQIYFFEG-------VAESVIVEDDVI 750
Query 764 EALETPVDSFT---NGAIVGTPVCVNGLMLLEIKDKEQYCALSPG---LLATNNVFRLKG 817
E +++ + S+ V ++ + + + DK ++ LL F G
Sbjct 751 ENVKSSLSSYEYCQPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLDQAWRFPCAG 810
Query 818 GAPIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVV 876
+ V F E V E+ V++ F+LD D +L + CS + VE G V +F VV
Sbjct 811 ----RKVNFNEKPVVMEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVV 866
Query 877 AEAVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEE 933
+A+ L D + + L++ + YLFD+AG+E +SRMYC+F D E+
Sbjct 867 CDAIENALNSCKDHPVVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDV 926
Query 934 DDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEP 993
+E E+ ID E ++D + E V + ++ED + + ++
Sbjct 927 ISSEAVEDTIDGVVEDTINDDEDVVTGDND----DEDVVTGDNDDEDVVTGDNDDEDVVT 982
Score = 174 bits (441), Expect = 2e-41, Method: Composition-based stats.
Identities = 55/157 (35%), Positives = 79/157 (50%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1328 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1387
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + LL AY++ N+ D L+ L+
Sbjct 1388 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1447
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1448 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1484
Score = 52.8 bits (125), Expect = 1e-04, Method: Composition-based stats.
Identities = 48/205 (23%), Positives = 76/205 (37%), Gaps = 18/205 (9%)
Query 1573 PTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTL----DESFLGRYMSALN 1628
D +I N + DD F+ Y L D ++S +
Sbjct 1049 DVVTGDNDDEEIVTGDNDDQIVVTGDDVDDIESVYDFDTYKALLVFNDVYNDALFVSYGS 1108
Query 1629 HTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFC 1688
+ + +V GL S NC+L SVLL +Q+L KF A++ + + G +F
Sbjct 1109 SVETETYFKVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFV 1168
Query 1689 ALILAYSNKTVGEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVM 1746
+L K + G V + L ++ N C CG + L G++AV
Sbjct 1169 DYLLTTIPKAIVLPQGGYVADFAYWFLNQFDI---NAYANWCCLKCGF-SFDLNGLDAVF 1224
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDAT 1771
+ G + VS C CG + T
Sbjct 1225 FYGDI--------VSHVCKCGHNMT 1241
Score = 48.2 bits (113), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1332 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1386
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1387 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1444
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1445 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1480
>sp|P0C6W9|R1AB_CVBM Replicase polyprotein 1ab OS=Bovine coronavirus
(strain Mebus) OX=11132 GN=rep PE=3 SV=1
Length=7094
Score = 3476 bits (9013), Expect = 0.0, Method: Composition-based stats.
Identities = 1071/2891 (37%), Positives = 1601/2891 (55%), Gaps = 105/2891 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCSKWQVVFNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L +KF QEA+ R+G A F +L+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLNLKFKIVQWQEAWLEFRSGRPARFVSLVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TGV+AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGVDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ + GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFKGD-KVGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGNLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E VT +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTVCDILNAKLGFDSSKEFVEYKVTEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEV 2004
V Y +++G KP++W ++ + + + +P+ +
Sbjct 1962 VLATDDLYVKRYERGCITFGKPVIWLSHEQASLNSLT---------YFNRPLLVDENKFD 2012
Query 2005 LAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVT 2064
+ D ES +E+ I+ ++ K +V +VI+ +K
Sbjct 2013 VLKVDDVDDGGDISESDAKEPKEI---NIIKLSGVK---KPFKVEDSVIVNDDTSEIKYV 2066
Query 2065 QELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLG 2124
+ L D+ ++ ++ N LS A+ + TI + V L
Sbjct 2067 KSLSIVDVYDMWLTGCRCVVRTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LNL 2121
Query 2125 QAAITTSNCAKRLAQRV--FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKS 2182
+ N K + ++ N++ ++F LLF + + T +A K
Sbjct 2122 REIKPVFNVVKAVRNKISACFNFIKWLFVLLFGWIKISADN----KVIYTTEVAS---KL 2174
Query 2183 VAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSYC 2240
KL A N + K+S + A + + + + I F L G P++
Sbjct 2175 TCKLVALAFKNAFLTFKWSVVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTFV 2234
Query 2241 NGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQVT 2287
+ + N+ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2235 GKIAQWIKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQYE 2294
Query 2288 ISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMW 2343
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W +
Sbjct 2295 ADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSVR 2354
Query 2344 FIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTI 2403
++S+ M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+TI
Sbjct 2355 LLVSLANMLPAHVFMRFYIIIASFIKLFSLFRHVAYGCSKSGCLFCYKRNRSLRVKCSTI 2414
Query 2404 VNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQ 2463
V GM R + ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2415 VGGMIRYYDAMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTDV 2474
Query 2464 SSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGK 2523
+ + V V + L++D+ GQ+TY+ S FV+ NL + K ++V+V +
Sbjct 2475 AYHTVTDVKQVGCYMRLFYDRDGQRTYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVEND 2534
Query 2524 SKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPM 2583
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2535 A--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVDK 2592
Query 2584 EKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEV 2642
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE+
Sbjct 2593 KSLNALIATAHSSIKQGTQICKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLEL 2652
Query 2643 TGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQL 2702
T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + LS
Sbjct 2653 TDESCNNLVPTYLKGDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQLSSDF 2712
Query 2703 RKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAAL 2762
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2713 QHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI--- 2769
Query 2763 VCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG-- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGLS 2829
Query 2821 SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI 2880
Y N +CP+V A++ ++ G V +P VLR LHF+ SA G CYTP I
Sbjct 2830 YYSNSMACPIVVAVVDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQI 2888
Query 2881 EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SII 2939
YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L + I
Sbjct 2889 SYSNFYASGCVLSSACTMFAMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGFI 2948
Query 2940 QFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVD 2999
+FP EG VR+V T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG D
Sbjct 2949 RFPEVLREGLVRIVRTRSMPYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGRD 3008
Query 3000 AMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANA 3059
+LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y +V N
Sbjct 3009 VFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSIVFVNV 3068
Query 3060 LLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITA 3119
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3069 IVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFCL 3128
Query 3120 IYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLT 3179
+Y+ + H W F+ +++ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3129 LYISVVVSNHAFWVFSYC--RQLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSDV 3184
Query 3180 QYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSAV 3238
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3185 AFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTSF 3244
Query 3239 LQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLL 3298
LQSG KM P+ KVE C+V VT G TLNGLWL D VYCPRHVIC+A DM NP+Y +LL
Sbjct 3245 LQSGIVKMVNPTSKVEPCIVSVTYGNMTLNGLWLGDKVYCPRHVICSASDMTNPDYTNLL 3304
Query 3299 IRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACY 3358
R ++ F V + L V+ + MQ C+L L V N +TPKY F ++PG+TF+VLA Y
Sbjct 3305 CRVTSSDFTVLFDRLSLTVMSYQMQGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAAY 3364
Query 3359 NGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLE 3418
NG P G + MR ++TIKGSFL GSCGSV + I DCV F YMH +EL TG H GTD
Sbjct 3365 NGKPQGAFHVTMRSSYTIKGSFLCGSCGSVVYVIMGDCVKFVYMHQLELSTGCHTGTDFN 3424
Query 3419 GKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYN 3478
G FYGP+ D Q Q D ++N +AWLYAA++N WF+ ++ DFN+ A+
Sbjct 3425 GDFYGPYKDAQVVQLPVQDYIQSVNFVAWLYAAILNNCNWFVQSDKCSVEDFNVWALSNG 3484
Query 3479 YEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVR 3538
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV +
Sbjct 3485 FSQVKSDLV--IDALASMTGVSLETLLAAIKHL-KNGFQGRQIMGSCSFEDELTPSDVYQ 3541
Query 3539 QCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAI 3598
Q +G+ Q K ++VKG W++ + I+ +W++F +V N L T + +
Sbjct 3542 QLAGIKLQSKRTRLVKGIVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MLSITFCALCV 3600
Query 3599 AACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ MLLVKHKH +L ++++P L T+ Y N +V ++ + WL S+ Y
Sbjct 3601 ISLTMLLVKHKHLYLTMYIIPVLFTLLYNNYLVVYKQTFRGYVYAWLSYYVPSVE-YTYT 3659
Query 3658 DCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVIS 3716
D V+Y L++ ++ +T R++ + + VI++V Y G+ L++ I + ++ S
Sbjct 3660 DEVIYGMLLLIGMVFVTLRSINQYLFSFIMFVGRVISVVSLWYMGSNLEEEILL--MLAS 3717
Query 3717 VTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCL 3776
+ Y+ M A+ I V L F ++ +++ Y F+GY CY+GLF L
Sbjct 3718 LFGTYTWTTALSMAAAKVIA-KWVAVNVLYFTDIPQIKIVLVCYLFIGYIISCYWGLFSL 3776
Query 3777 LNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQ 3836
+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+ Q
Sbjct 3777 MNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQFQ 3836
Query 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLL 3896
SK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D AFEK+ LL VL
Sbjct 3837 SKLTDVKCANVVLLNCLQHLHVASNSKLWQYCSTLHNEILATSDLGVAFEKLAQLLIVLF 3896
Query 3897 SMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDS 3950
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A ++G +
Sbjct 3897 ANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEACSSGSA 3956
Query 3951 -EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTM 4009
+ LK+L+K+ N+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTM
Sbjct 3957 NQQQLKQLEKACNIAKSAYERDRAVARKLERMADLALTNMYKEARINDKKSKVVSALQTM 4016
Query 4010 LFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYA 4069
LF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TYA
Sbjct 4017 LFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLTIIVPDKSVYDQVVDNVYVTYA 4076
Query 4070 SALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVALR 4127
+W+IQ + D+D QL EI S + WPL++ A R N SA LQNNEL P L+
Sbjct 4077 GNVWQIQTIQDSDGTNKQLHEI----SDDCNWPLVIIANRHNEVSATALQNNELMPAKLK 4132
Query 4128 QMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELE 4187
+G QT T YYNNS G+ V A+LSD LK+ + K DG + EL+
Sbjct 4133 TQVVNSGPDQTCNTPTQ--CYYNNSYNGKIVYAILSDVDGLKYTKILKDDGNFVV-LELD 4189
Query 4188 PPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFC 4247
PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS C
Sbjct 4190 PPCKFTVQDVKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSLC 4249
Query 4248 AFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYC 4307
AF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+YC
Sbjct 4250 AFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYC 4309
Query 4308 RCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPL 4367
R ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4310 RARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCQVCGFWRDGSCSCVST-DTT 4367
Query 4368 MQSADASTFLN 4378
+QS D + FLN
Sbjct 4368 VQSKD-TNFLN 4377
Score = 305 bits (780), Expect = 7e-81, Method: Composition-based stats.
Identities = 181/972 (19%), Positives = 328/972 (34%), Gaps = 151/972 (16%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + + K D D + +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKCGEKGAYNKDHKRGGFEHVYNFKVEDAYDLVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMCTL- 215
L R G YVD C G L+ D + K++ +
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGGLADGLEAYADKTLQEMKALFPIW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I+S D G
Sbjct 287 SQELPF-------------DVTVAWHVVRDPRYVMRLQSASTIRSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + V+ + + Y V ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQHNLVDIMSCFYMEADAVVNAFYGVD-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEGP-TTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG + + G LP N V+
Sbjct 393 EQDLCDFKGWVPGNMIDGFACTTCGHVYETGDLLAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADI----GSGH 435
S A Y ++ G FGGCV+ R W+P + + G +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDGLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVVGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLLNRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A + + +LD +D++ L + ++ +A Q
Sbjct 603 DYAGKICHAVVSKSKELLD-------VSLDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ SK GL
Sbjct 698 RYASAVAQAFRSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGSKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP K ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKTKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDGHVGLLDQAWRVPCAG--RCVTFKEQPTVNEIASTP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD+ + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KTIKVFYELDKDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + + +LFD+AGEE + ++YC+F P EDD EE ++E T+
Sbjct 931 SAFLQKLEDNSLFLFDEAGEEVLAPKLYCAFTAP----EDDDFLEESGVEEDDVEGEETD 986
Query 955 DDYQGLPLEFGASAE-TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVN--QFTGYLK 1011
L ++ E V E+EE + L+DT + + EE V F
Sbjct 987 -------LTVTSAGEPCVASEQEESSEILEDTLDDGPCVETSDSQVEEDVQMSDFVDLES 1039
Query 1012 LTDNVAIKCVDI 1023
+ + C +
Sbjct 1040 VIQDYENVCFEF 1051
Score = 178 bits (451), Expect = 1e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 79/156 (51%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ D +K
Sbjct 1272 CITPNVCFVKGDIIKVSKRVKAEVVVNPANGHMAHGGGVAKAIAVAAGQQFVKETTDMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++ N D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYALLERVYKHLNKYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T + QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 47.0 bits (110), Expect = 0.006, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 60/150 (40%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V L K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLDLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N V + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVVPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHVCKCGESMV--LIDVDVPF 1192
>sp|P0C6U7|R1A_CVHOC Replicase polyprotein 1a OS=Human coronavirus
OC43 OX=31631 GN=1a PE=1 SV=1
Length=4383
Score = 3474 bits (9008), Expect = 0.0, Method: Composition-based stats.
Identities = 1076/2896 (37%), Positives = 1606/2896 (55%), Gaps = 107/2896 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCFKWQVVVNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L + F QEA+ R+G A F AL+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLHLTFKIVQWQEAWLEFRSGRPARFVALVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TG++AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGLDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFIGDN-VGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGKLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E +T +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTVCDSLNSKLGFDSSKEFVEYKITEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTS-NSFE 2003
V + Y +++G KP++W ++ + + + +P+ N F
Sbjct 1962 VLANDDLYVKRYERGCITFGKPVIWLSHEKASLNSLT---------YFNRPLLVDDNKF- 2011
Query 2004 VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKV 2063
+ + +S + ++E E I+ ++ K +V +VI+ K
Sbjct 2012 ---DVLKVDDVDDSGDSSESGAKETKEINIIKLSGVK---KPFKVEDSVIVNDDTSETKY 2065
Query 2064 TQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFL 2123
+ L D+ ++ ++ N LS A+ + TI + V L
Sbjct 2066 VKSLSIVDVYDMWLTGCKYVVRTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LN 2120
Query 2124 GQAAITTSNCAKRLAQR--VFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVK 2181
+ N K + + N++ ++F LLF + + T IA K
Sbjct 2121 LREIKPAVNVVKAVRNKTSACFNFIKWLFVLLFGWIKISADN----KVIYTTEIAS---K 2173
Query 2182 SVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSY 2239
KL A N + K+S + A + + + + I F L G P++
Sbjct 2174 LTCKLVALAFKNAFLTFKWSMVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTF 2233
Query 2240 CNGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQV 2286
+ + N+ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2234 VGKIAQWIKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQY 2293
Query 2287 TISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLM 2342
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W
Sbjct 2294 EADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSF 2353
Query 2343 WFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTT 2402
++++ M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+T
Sbjct 2354 RLLVALANMLPAHVFMRFYIIIASFIKLFSLFKHVAYGCSKSGCLFCYKRNRSLRVKCST 2413
Query 2403 IVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTD 2462
IV GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2414 IVGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTD 2473
Query 2463 QSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDG 2522
+ + V V ++ L++D+ GQ+ Y+ S FV+ NL + K ++V+V +
Sbjct 2474 VAYHTVTDVKQVGCSMRLFYDRDGQRIYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVEN 2533
Query 2523 KSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVP 2582
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2534 DA--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVD 2591
Query 2583 MEKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLE 2641
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE
Sbjct 2592 KKSLNALIATAHSSIKQGTQIYKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLE 2651
Query 2642 VTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQ 2701
+T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + S
Sbjct 2652 LTDESCNNLVPTYLKSDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQFSSD 2711
Query 2702 LRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAA 2761
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2712 FQHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI-- 2769
Query 2762 LVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 -GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGL 2828
Query 2821 -SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
Y N +CP+V A+I ++ G V +P VLR LHF+ SA G CYTP
Sbjct 2829 SYYSNSMACPIVVAVIDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQ 2887
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SI 2938
I YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L +
Sbjct 2888 ISYSNFYASGCVLSSACTMFTMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGF 2947
Query 2939 IQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGV 2998
I+FP EG VRVV T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG
Sbjct 2948 IRFPEVLREGLVRVVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGR 3007
Query 2999 DAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAAN 3058
D +LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y VV N
Sbjct 3008 DVFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVN 3067
Query 3059 ALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWIT 3118
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3068 VIVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFC 3127
Query 3119 AIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+Y+ + H W F+ +++ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3128 LLYIAVVVSNHAFWVFSYC--RKLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCVVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + M+ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMRGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N LAWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPIQDYIQSVNFLAWLYAAILNNCNWFIQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA 3597
+Q +G+ Q K ++ KGT W++ + I+ +W++F +V N T +
Sbjct 3541 QQLAGIKLQSKRTRLFKGTVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MFSITFCALC 3599
Query 3598 IAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRL 3656
+ + AMLLVKHKH +L +++ P L T+ Y N +V ++ + WL S+ Y
Sbjct 3600 VISLAMLLVKHKHLYLTMYITPVLFTLLYNNYLVVYKHTFRGYVYAWLSYYVPSVE-YTY 3658
Query 3657 KDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVI 3715
D V+Y L++ ++ +T R++ D + + +I++ Y G+ L++ I + ++
Sbjct 3659 TDEVIYGMLLLVGMVFVTLRSINHDLFSFIMFVGRLISVFSLWYKGSNLEEEILL--MLA 3716
Query 3716 SVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFC 3775
S+ Y+ M +A+ I V L F ++ ++L Y F+GY CY+GLF
Sbjct 3717 SLFGTYTWTTVLSMAVAKVIA-KWVAVNVLYFTDIPQIKIVLLCYLFIGYIISCYWGLFS 3775
Query 3776 LLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATV 3835
L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3776 LMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQF 3835
Query 3836 QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVL 3895
QSK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D + AFEK+ LL VL
Sbjct 3836 QSKLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVL 3895
Query 3896 LSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A +G
Sbjct 3896 FANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARFSGS 3955
Query 3950 S-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQT 4008
+ + LK+L+K+ N+AKS ++RD A+ +KLE+MAD A+T MYK+AR DK++KV SA+QT
Sbjct 3956 ANQQQLKQLEKACNIAKSAYERDRAVAKKLERMADLALTNMYKEARINDKKSKVVSALQT 4015
Query 4009 MLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTY 4068
MLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TY
Sbjct 4016 MLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLNIIVPDKSVYDQIVDNIYVTY 4075
Query 4069 ASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVAL 4126
A +W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L
Sbjct 4076 AGNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRYNEVSATVLQNNELMPAKL 4131
Query 4127 RQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTEL 4186
+ +G QT T YYNNS G+ V A+LSD LK+ + K DG + EL
Sbjct 4132 KIQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LEL 4188
Query 4187 EPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSF 4246
+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS
Sbjct 4189 DPPCKFTVQDAKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSL 4248
Query 4247 CAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLY 4306
CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+Y
Sbjct 4249 CAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIY 4308
Query 4307 CRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP 4366
CR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4309 CRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCRVCGFWRDGSCSCVST-DT 4366
Query 4367 LMQSADASTFLNGFAV 4382
+QS D + FLNGF V
Sbjct 4367 TVQSKD-TNFLNGFGV 4381
Score = 298 bits (764), Expect = 4e-79, Method: Composition-based stats.
Identities = 181/971 (19%), Positives = 329/971 (34%), Gaps = 149/971 (15%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + D K D D++ +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKRGEKGAYNKDHGCGGFGHVYDFKVEDAYDQVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMC-TL 215
L R G YVD C G L+ D + K++ T
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGSLADGLEAYADKTLQEMKALFPTW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I S D G
Sbjct 287 SQELPF-------------DVIVAWHVVRDPRYVMRLQSAATICSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + + + + Y VA ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQYNLFDIMSHFYMEADTVVNAFYGVA-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG V + + G LP N V+
Sbjct 393 EQDSCDFKGWIPGNMIDGFACTTCGHVYEVGDLIAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGS----GH 435
S A Y ++ G FGGCV+ R W+P + + S +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDSLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVLGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLINRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKLCHAVVSKSKELLD-------VSLDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ K GL
Sbjct 698 RYASAVAQAFQSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGRKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDDHVGLLDQAWRVPCAG--RRVTFKEQPTVKEIISMP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KIIKVFYELDNDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + +LFD+AGEE F+ ++YC+F P +++ ++E+ E E
Sbjct 931 SAFLQKLEDNPLFLFDEAGEEVFAPKLYCAFTAP---------EDDDFLEESDVEEDDVE 981
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLKL 1012
+ L + A V E+EE + L+DT + + EE V + F +
Sbjct 982 GEETDLTIT-SAGQPCVASEQEESSEVLEDTLDDGPSVETSDSQVEEDVEMSDFVDLESV 1040
Query 1013 TDNVAIKCVDI 1023
+ C +
Sbjct 1041 IQDYENVCFEF 1051
Score = 176 bits (447), Expect = 4e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 81/156 (52%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ + +K
Sbjct 1272 CITPNVCFVKGDIIKVSKLVKAEVVVNPANGHMVHGGGVAKAIAVAAGQQFVKETTNMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++FN+ D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYVLLERVYKHFNNYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T + QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 48.2 bits (113), Expect = 0.003, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 61/150 (41%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V GL K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLGLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N + + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVLPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHICKCGESMV--LIDVDVPF 1192
>sp|P0C6X3|R1AB_CVHN2 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N2) OX=443240 GN=rep PE=3 SV=1
Length=7152
Score = 3473 bits (9006), Expect = 0.0, Method: Composition-based stats.
Identities = 1054/2938 (36%), Positives = 1585/2938 (54%), Gaps = 112/2938 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1563 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1618
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1619 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1678
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1679 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1737
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1738 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1797
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1798 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1855
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1856 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1913
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1914 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1972
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 1973 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2030
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2031 KGCETFGKPVIWLCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2075
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2076 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2135
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2136 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2194
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2195 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2248
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2249 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2308
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2309 CDFYSKLGVG----FTSHFCNGSFICELCYSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2364
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2365 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2424
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2425 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2484
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2485 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2544
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2545 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2602
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2603 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2662
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2663 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2722
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2723 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDTFNQLTADLQHKLKKACVKTG 2782
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2783 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2839
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2840 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSFYYHNSMDCPIVV 2899
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2900 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2958
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2959 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3018
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3019 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3078
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3079 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3138
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3139 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3198
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3199 WLFSYC--RKIGVNVCNDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3254
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3255 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3314
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3315 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3374
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3375 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3434
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3435 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3494
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3495 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3552
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3553 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3611
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3612 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3670
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3671 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGLTYVWLSYFVPAVNFTYVYEVFYGCILCVFA 3730
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3731 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3788
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3789 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3847
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3848 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3907
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+S+LW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3908 LNCLQHLHVASNSRLWQYCSILHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKCLAS 3967
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3968 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4027
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4028 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4087
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPLN IP A L +++PD + D YA ++W IQ V DAD
Sbjct 4088 NSILDNAVKGCVPLNAIPALAANTLTIIIPDKQVFDKVVDNVYVAYAGSVWHIQTVQDAD 4147
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4148 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDMNCN 4203
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4204 IPTQ--CYYNNGSSGRIVYAVLSDVDGLKYTKIIKDDGNCVV-LELDPPCKFSIQDVKGL 4260
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4261 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4320
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4321 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGLC 4380
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLN
Sbjct 4381 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SGVAVQSKDL-NFLN 4435
Score = 283 bits (723), Expect = 3e-74, Method: Composition-based stats.
Identities = 150/900 (17%), Positives = 290/900 (32%), Gaps = 149/900 (17%)
Query 141 KSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDC 200
+D D D + K+ A L R+ G +VD C G DC
Sbjct 185 FKFDDYDFSVEDAYAEVHAEPKGKYSQKAYA-LLRQYRGIKPVLFVDQYGCDYSGKLADC 243
Query 201 IKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKS 259
A S+ + ++ + +AW R + QT I
Sbjct 244 ---LQAYGHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICG 294
Query 260 AKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLST 319
K + + V ++ K M V +++
Sbjct 295 IKYVAQPTEDVVDGAVVIREPVHLLSADAIVLKLPSLM----KVMTHMDDFSIKSIYNVD 350
Query 320 LMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIG 379
L C + + C +N G + + + C D
Sbjct 351 LCDCGFVMQYGYV----------DCFNDNCDFYGWVSGNMM--DGFSCPLCCTVYDSSEV 398
Query 380 PEHS---VADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHT 436
S + + T +G V G YW PR
Sbjct 399 KAQSSGVIPENPVLFTNSTDTVNPDSFNLYGYSV-TPFGSC---IYWSPRP--------- 445
Query 437 GITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSLDY 496
G+ +++ + ++ + + S +T
Sbjct 446 GLWIPIIKSSVKSYDDL----------------------VYSGVVGCKSIVKETALITHA 483
Query 497 KSFKTIVESCGNYKVTKGKPVKGAW------NIGQQRSVLTPLCGFPSQAAGVIR--SIF 548
+ CGN + V +W N G +L + F + A ++
Sbjct 484 LYLDYVQCKCGNLEQNHILGVNNSWCRQLLLNRGDYNMLLKNIDLFVKRRADFACKFAVC 543
Query 549 ARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYT-------SDLLTNSVIIMAYV 601
+LDG+ +S L+ + ++ S +++ + M +
Sbjct 544 GDGF-------------VPFLLDGLIPRSYYLIQSGIFFTSLMSQFSQEVSDMCLKMCIL 590
Query 602 TGGLVQQTSQWLSNLLGTTVEK--------LRPIFEWIEAKLSAGVEFLKDAWEILKFLI 653
V + ++ + + V + + + W L A W + + L+
Sbjct 591 FMDRVSVATFYIEHYVNRLVTQFKLLGTTLVNKMVNWFNTMLDASAP--ATGWLLYQ-LL 647
Query 654 TGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----LRSLN----- 704
G+F + + + I D K ++ ++ ++ VT+ K L+++N
Sbjct 648 NGLFVVSQANFNFVA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCI 706
Query 705 LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGEL 763
+G F S GL ++P A +++ F EG +E V++++ +
Sbjct 707 VGNKFYNVSTGLI---------PGFVLPCNAQEQQIYFFEG-------VAESVIVEDDVI 750
Query 764 EALETPVDSFT---NGAIVGTPVCVNGLMLLEIKDKEQYCALSPG---LLATNNVFRLKG 817
E +++ + S+ V ++ + + + DK ++ LL F G
Sbjct 751 ENVKSSLSSYEYCQPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLDQAWRFPCAG 810
Query 818 GAPIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVV 876
+ V F E V E+ V++ F+LD D +L + CS + VE G V +F VV
Sbjct 811 ----RKVNFNEKPVVMEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVV 866
Query 877 AEAVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEE 933
+A+ L D + + L++ + YLFD+AG+E +SRMYC+F D E+
Sbjct 867 CDAIENALNSCKDHPVVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDV 926
Query 934 DDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEP 993
+E E+ ID E ++D + E V + ++ED + + ++
Sbjct 927 ISSEAVEDTIDGVVEDTINDDEDVVTGDND----DEDVVTGDNDDEDVVTGDNDDEDVVT 982
Score = 174 bits (441), Expect = 2e-41, Method: Composition-based stats.
Identities = 55/157 (35%), Positives = 79/157 (50%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1328 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1387
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + LL AY++ N+ D L+ L+
Sbjct 1388 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1447
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1448 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1484
Score = 52.8 bits (125), Expect = 1e-04, Method: Composition-based stats.
Identities = 48/205 (23%), Positives = 76/205 (37%), Gaps = 18/205 (9%)
Query 1573 PTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTL----DESFLGRYMSALN 1628
D +I N + DD F+ Y L D ++S +
Sbjct 1049 DVVTGDNDDEEIVTGDNDDQIVVTGDDVDDIESVYDFDTYKALLVFNDVYNDALFVSYGS 1108
Query 1629 HTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFC 1688
+ + +V GL S NC+L SVLL +Q+L KF A++ + + G +F
Sbjct 1109 SVETETYFKVNGLWSPTITHTNCWLRSVLLVMQKLPFKFKDLAIENMWLSYKVGYNQSFV 1168
Query 1689 ALILAYSNKTVGEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVM 1746
+L K + G V + L ++ N C CG + L G++AV
Sbjct 1169 DYLLTTIPKAIVLPQGGYVADFAYWFLNQFDI---NAYANWCCLKCGF-SFDLNGLDAVF 1224
Query 1747 YMGTLSYDNLKTGVSIPCVCGRDAT 1771
+ G + VS C CG + T
Sbjct 1225 FYGDI--------VSHVCKCGHNMT 1241
Score = 48.6 bits (114), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1332 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1386
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1387 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1444
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1445 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1480
>sp|P0C6X4|R1AB_CVHN5 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N5) OX=443241 GN=rep PE=3 SV=1
Length=7132
Score = 3471 bits (8999), Expect = 0.0, Method: Composition-based stats.
Identities = 1056/2938 (36%), Positives = 1586/2938 (54%), Gaps = 112/2938 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1543 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1598
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1599 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1658
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1659 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1717
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1718 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1777
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1778 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1835
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1836 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1893
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1894 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1952
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 1953 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2010
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2011 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2055
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2056 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2115
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2116 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2174
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2175 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2228
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2229 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2288
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2289 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2344
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2345 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2404
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2405 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2464
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2465 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2524
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2525 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2582
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2583 VFYAQSLYRPILLVDKKLITTACNGISVTQIMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2642
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2643 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2702
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK N+S IW + + L+ L+ +++ A K
Sbjct 2703 LKSDNIVAADLGVLIQNGAKHVQGNVAKVANISCIWFIDAFNQLTADLQHKLKKACVKTG 2762
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2763 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2819
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2820 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2879
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2880 AVMDEDIGSTMFNVPTKVLR-YGFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2938
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2939 SSLCTMFKRGDGTPHPYCYTDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 2998
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 2999 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFSSL 3058
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3059 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3118
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3119 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3178
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3179 WLFSYC--RKIGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3234
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3235 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3294
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3295 SKIEPCLVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3354
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3355 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3414
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3415 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFNGNFYGPYRDAQV 3474
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3475 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3532
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3533 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3591
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3592 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3650
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3651 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSHFVPAVNFTYVYEVFYGCILCVFA 3710
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3711 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3768
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3769 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3827
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3828 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3887
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL S AVD
Sbjct 3888 LNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFSNPAAVDTKCLAS 3947
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3948 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4007
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4008 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4067
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPL+ IP A L +++PD + D TYA ++W IQ V DAD
Sbjct 4068 NSILDNAVKGCVPLSAIPALAANTLTIIIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDAD 4127
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4128 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDINCN 4183
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4184 IPTQ--CYYNNVSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDVKGL 4240
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4241 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4300
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4301 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGIC 4360
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLN
Sbjct 4361 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKDL-NFLN 4415
Score = 293 bits (749), Expect = 2e-77, Method: Composition-based stats.
Identities = 159/885 (18%), Positives = 309/885 (35%), Gaps = 141/885 (16%)
Query 148 ELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLAR 207
E+ +P Y Q L R+ G +VD C G DC A
Sbjct 200 EVHAEPKGKYSQKAYA---------LLRQYRGIKPVLFVDQYGCDYSGKLADC---LQAY 247
Query 208 AGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK----- 261
S+ + ++ + +AW R + QT I K
Sbjct 248 GHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICGIKYVAQP 301
Query 262 KFDTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHL 317
D G+ P + ++ V + P + K T I+S+Y V +C +
Sbjct 302 TEDVVDGDVVIREPVHLLSADAIVLKL-PSLMKVMTHMDDFSIKSIYNVD-LCDCGFVMQ 359
Query 318 STLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVVKMPCPAC 373
+ C ++CD W + + + C T E + G +P N V+
Sbjct 360 YGYVDCFNDNCDFYGWVSGNMMDGFSCPLCCTVYDSSEVKAQSSGVIPENPVLFTNSTDT 419
Query 374 QDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASAD--- 430
+P+ + G FG C++ + W+P +
Sbjct 420 VNPDSFNLY-----------------GYSVTPFGSCIY----WSPRPGLWIPIIKSSVKS 458
Query 431 ----IGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA 486
+ SG G ET L + G+ N +
Sbjct 459 YDDLVYSGVVGCKSIVKETALITHALYLDYVQCK---CGNLEQNHIL------------- 502
Query 487 FIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRS 546
++ + ++ + G+Y + K + + +CG ++
Sbjct 503 ------GVNNSWCRQLLLNRGDYNMLL-KNIDLFVKRRADFACKFAVCGDGF-VPFLLDG 554
Query 547 IFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLV 606
+ R+ L ++ + +S+ S + D + L + V + + V
Sbjct 555 LIPRSY--------YLIQSGIFFTSLMSQFSQEVSDMCLKMCILFMDRVSVATFYIEHYV 606
Query 607 QQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQV 666
+ LLGTT+ + + W L A W + + L+ G F + + +
Sbjct 607 NRLVTQF-KLLGTTL--VNKMVNWFNTMLDASAP--ATGWLLYQ-LLNGFFVVSQANLNF 660
Query 667 ASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLY 717
+ I D K ++ ++ ++ VT+ K L+++N +G F S GL
Sbjct 661 VA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGLI 719
Query 718 RQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFT-- 774
++P A +++ F EG +E V++++ +E +++ + S+
Sbjct 720 ---------PGFVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYC 763
Query 775 -NGAIVGTPVCVNGLMLLEIKDKEQYCALSP-GLLATNNVFRLKGGAPIKGVTFGED-TV 831
V ++ + + + DK ++ + ++ +R + V F E V
Sbjct 764 QPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLDHAWRFPCAG--RKVNFNEKPVV 821
Query 832 WEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD-- 889
E+ V++ F+LD D +L + CS + VE G V +F VV +A+ L +
Sbjct 822 MEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHP 881
Query 890 -LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE 948
+ + L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E
Sbjct 882 VVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVE 941
Query 949 HEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEP 993
++D + E V + ++ED + + ++
Sbjct 942 DTINDDEDVVTGDND----DEDVVTGDNDDEDVVTGDNDDEDVVT 982
Score = 174 bits (441), Expect = 2e-41, Method: Composition-based stats.
Identities = 55/157 (35%), Positives = 79/157 (50%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1308 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1367
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + LL AY++ N+ D L+ L+
Sbjct 1368 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1427
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1428 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1464
Score = 51.6 bits (122), Expect = 3e-04, Method: Composition-based stats.
Identities = 45/177 (25%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query 1601 DDTLRSEAFEYYHTL----DESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSV 1656
DD F+ Y L D ++S + + + +V GL S NC+L SV
Sbjct 1057 DDIESIYDFDTYKALLVFNDVYNDALFVSYGSSVETETYFKVNGLWSPTITHTNCWLRSV 1116
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQ 1714
LL +Q+L KF A++ + + G +F +L K + G V + L
Sbjct 1117 LLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIPKAIVLPQGGYVADFAYWFLN 1176
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ N C CG + L G++AV + G + VS C CG + T
Sbjct 1177 QFDI---NAYANWCCLKCGF-SFDLNGLDAVFFYGDI--------VSHVCKCGHNMT 1221
Score = 48.6 bits (114), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1312 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1366
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1367 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1424
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1425 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1460
>sp|P0C6U5|R1A_CVHN5 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N5) OX=443241 GN=1a PE=3 SV=1
Length=4421
Score = 3470 bits (8997), Expect = 0.0, Method: Composition-based stats.
Identities = 1058/2942 (36%), Positives = 1588/2942 (54%), Gaps = 112/2942 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1543 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1598
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1599 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1658
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1659 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1717
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1718 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1777
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1778 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1835
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1836 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1893
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1894 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 1952
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 1953 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2010
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2011 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2055
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2056 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2115
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2116 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2174
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2175 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2228
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2229 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2288
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2289 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2344
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2345 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2404
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2405 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2464
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2465 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2524
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2525 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2582
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2583 VFYAQSLYRPILLVDKKLITTACNGISVTQIMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2642
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2643 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2702
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK N+S IW + + L+ L+ +++ A K
Sbjct 2703 LKSDNIVAADLGVLIQNGAKHVQGNVAKVANISCIWFIDAFNQLTADLQHKLKKACVKTG 2762
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2763 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFISLICFI---LLWALLPTYSVY 2819
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2820 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2879
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2880 AVMDEDIGSTMFNVPTKVLR-YGFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2938
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2939 SSLCTMFKRGDGTPHPYCYTDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 2998
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 2999 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDFFDLFYQFFSSL 3058
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3059 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVIVWCINFLMLFV 3118
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3119 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3178
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3179 WLFSYC--RKIGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3234
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3235 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3294
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC + +M P+Y LL R + F + +
Sbjct 3295 SKIEPCLVSVTYGSMTLNGLWLDDKVYCPRHVICLSSNMNEPDYSALLCRVTLGDFTIMS 3354
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3355 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGVVKPGETFTVLAAYNGRPQGAFHVTM 3414
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3415 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFNGNFYGPYRDAQV 3474
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ ++ DFN+ AM + + D V L
Sbjct 3475 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSIEDFNVWAMTNGFSQVKADLV--L 3532
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3533 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3591
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3592 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3650
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3651 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSHFVPAVNFTYVYEVFYGCILCVFA 3710
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3711 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3768
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3769 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3827
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3828 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3887
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL S AVD
Sbjct 3888 LNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFSNPAAVDTKCLAS 3947
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3948 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4007
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4008 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4067
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPL+ IP A L +++PD + D TYA ++W IQ V DAD
Sbjct 4068 NSILDNAVKGCVPLSAIPALAANTLTIIIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDAD 4127
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4128 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDINCN 4183
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4184 IPTQ--CYYNNVSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDVKGL 4240
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4241 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4300
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4301 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGIC 4360
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLNG
Sbjct 4361 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKDL-NFLNGL 4417
Query 4381 AV 4382
V
Sbjct 4418 GV 4419
Score = 292 bits (747), Expect = 4e-77, Method: Composition-based stats.
Identities = 159/885 (18%), Positives = 309/885 (35%), Gaps = 141/885 (16%)
Query 148 ELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDCIKDFLAR 207
E+ +P Y Q L R+ G +VD C G DC A
Sbjct 200 EVHAEPKGKYSQKAYA---------LLRQYRGIKPVLFVDQYGCDYSGKLADC---LQAY 247
Query 208 AGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK----- 261
S+ + ++ + +AW R + QT I K
Sbjct 248 GHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICGIKYVAQP 301
Query 262 KFDTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHL 317
D G+ P + ++ V + P + K T I+S+Y V +C +
Sbjct 302 TEDVVDGDVVIREPVHLLSADAIVLKL-PSLMKVMTHMDDFSIKSIYNVD-LCDCGFVMQ 359
Query 318 STLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVVKMPCPAC 373
+ C ++CD W + + + C T E + G +P N V+
Sbjct 360 YGYVDCFNDNCDFYGWVSGNMMDGFSCPLCCTVYDSSEVKAQSSGVIPENPVLFTNSTDT 419
Query 374 QDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASAD--- 430
+P+ + G FG C++ + W+P +
Sbjct 420 VNPDSFNLY-----------------GYSVTPFGSCIY----WSPRPGLWIPIIKSSVKS 458
Query 431 ----IGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSA 486
+ SG G ET L + G+ N +
Sbjct 459 YDDLVYSGVVGCKSIVKETALITHALYLDYVQCK---CGNLEQNHIL------------- 502
Query 487 FIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRS 546
++ + ++ + G+Y + K + + +CG ++
Sbjct 503 ------GVNNSWCRQLLLNRGDYNMLL-KNIDLFVKRRADFACKFAVCGDGF-VPFLLDG 554
Query 547 IFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLV 606
+ R+ L ++ + +S+ S + D + L + V + + V
Sbjct 555 LIPRSY--------YLIQSGIFFTSLMSQFSQEVSDMCLKMCILFMDRVSVATFYIEHYV 606
Query 607 QQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQV 666
+ LLGTT+ + + W L A W + + L+ G F + + +
Sbjct 607 NRLVTQF-KLLGTTL--VNKMVNWFNTMLDASAP--ATGWLLYQ-LLNGFFVVSQANLNF 660
Query 667 ASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----LRSLN-----LGEVFIAQSKGLY 717
+ I D K ++ ++ ++ VT+ K L+++N +G F S GL
Sbjct 661 VA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVLKTINGLVCIVGNKFYNVSTGLI 719
Query 718 RQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFT-- 774
++P A +++ F EG +E V++++ +E +++ + S+
Sbjct 720 ---------PGFVLPCNAQEQQIYFFEG-------VAESVIVEDDVIENVKSSLSSYEYC 763
Query 775 -NGAIVGTPVCVNGLMLLEIKDKEQYCALSP-GLLATNNVFRLKGGAPIKGVTFGED-TV 831
V ++ + + + DK ++ + ++ +R + V F E V
Sbjct 764 QPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLDHAWRFPCAG--RKVNFNEKPVV 821
Query 832 WEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD-- 889
E+ V++ F+LD D +L + CS + VE G V +F VV +A+ L +
Sbjct 822 MEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGVTVDDFVAVVCDAIENALNSCKEHP 881
Query 890 -LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCE 948
+ + L++ + YLFD+AG+E +SRMYC+F D E+ +E E+ ID E
Sbjct 882 VVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCTFAIEDVEDVISSEAVEDTIDGVVE 941
Query 949 HEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEP 993
++D + E V + ++ED + + ++
Sbjct 942 DTINDDEDVVTGDND----DEDVVTGDNDDEDVVTGDNDDEDVVT 982
Score = 174 bits (441), Expect = 2e-41, Method: Composition-based stats.
Identities = 55/157 (35%), Positives = 79/157 (50%), Gaps = 2/157 (1%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE+ +
Sbjct 1308 LCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKETAAMV 1367
Query 1070 KLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLL 1127
K G VG + +G L K L++VGP+ + LL AY++ N+ D L+ L+
Sbjct 1368 KSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCCLSTLI 1427
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
SAGIF SL + V QV + N+K ++ +
Sbjct 1428 SAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1464
Score = 51.3 bits (121), Expect = 3e-04, Method: Composition-based stats.
Identities = 45/177 (25%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query 1601 DDTLRSEAFEYYHTL----DESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSV 1656
DD F+ Y L D ++S + + + +V GL S NC+L SV
Sbjct 1057 DDIESIYDFDTYKALLVFNDVYNDALFVSYGSSVETETYFKVNGLWSPTITHTNCWLRSV 1116
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQ 1714
LL +Q+L KF A++ + + G +F +L K + G V + L
Sbjct 1117 LLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIPKAIVLPQGGYVADFAYWFLN 1176
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ N C CG + L G++AV + G + VS C CG + T
Sbjct 1177 QFDI---NAYANWCCLKCGF-SFDLNGLDAVFFYGDI--------VSHVCKCGHNMT 1221
Score = 48.2 bits (113), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1312 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1366
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1367 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1424
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1425 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1460
>sp|P0C6X6|R1AB_CVHOC Replicase polyprotein 1ab OS=Human coronavirus
OC43 OX=31631 GN=rep PE=1 SV=1
Length=7095
Score = 3470 bits (8997), Expect = 0.0, Method: Composition-based stats.
Identities = 1073/2892 (37%), Positives = 1603/2892 (55%), Gaps = 107/2892 (4%)
Query 1528 LSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPH 1587
++ ++K+L + + + TVD N + V + ++G+ G + DG +VTK K
Sbjct 1552 ATVAQIKALF----LDKVDILLTVDGVNFTNRFVPVGESFGKSLGNVFCDGVNVTKHKCD 1607
Query 1588 VNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWA 1647
+N++GK FF + + +A D+ L Y + L + KW+ G + K A
Sbjct 1608 INYKGKVFFQFDNLSSEDLKAVRSSFNFDQKELLAYYNMLVNCFKWQVVVNGKYFTFKQA 1667
Query 1648 DNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRE 1707
+NNC+++ L LQ L + F QEA+ R+G A F AL+LA G+ D R+
Sbjct 1668 NNNCFVNVSCLMLQSLHLTFKIVQWQEAWLEFRSGRPARFVALVLAKGGFKFGDPADSRD 1727
Query 1708 TMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCG 1767
+ + +L A + CK CG K TG++AVM+ GTLS ++L+ G ++ C CG
Sbjct 1728 FLRVVFSQVDLTGAICDFEIACK-CGVKQEQRTGLDAVMHFGTLSREDLEIGYTVDCSCG 1786
Query 1768 RDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDG 1827
+ + V+ + F++ S PA KL +G AN + G+ GHY H+ +++ D
Sbjct 1787 KKLI-HCVRFDVPFLICSNTPASVKLPKGVG-SANIFIGDN-VGHYVHVKCEQSYQLYDA 1843
Query 1828 AHLTKMSEYKGPVTDVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTE 1886
+++ K+++ G ++D Y K T +Y LD V E +P L YY YYT+
Sbjct 1844 SNVKKVTDVTGKLSDCLYLKNLKQTFKSVLTTYYLDDVKKIEYKPDLSQYYCDGGKYYTQ 1903
Query 1887 QPIDL-VPTQPLPNASFDNFKLTCSNTKFADDLNQMTGF-TKPASRELSVTFFPDLNGDV 1944
+ I T + + NFKL D LN GF + E +T +P GDV
Sbjct 1904 RIIKAQFKTFEKVDGVYTNFKLI--GHTVCDSLNSKLGFDSSKEFVEYKITEWPTATGDV 1961
Query 1945 VAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTS-NSFE 2003
V + Y +++G KP++W ++ + + + +P+ N F
Sbjct 1962 VLANDDLYVKRYERGCITFGKPVIWLSHEKASLNSLT---------YFNRPLLVDDNKF- 2011
Query 2004 VLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKV 2063
+ + +S + ++E E I+ ++ K +V +VI+ K
Sbjct 2012 ---DVLKVDDVDDSGDSSESGAKETKEINIIKLSGVK---KPFKVEDSVIVNDDTSETKY 2065
Query 2064 TQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFL 2123
+ L D+ ++ ++ N LS A+ + TI + V L
Sbjct 2066 VKSLSIVDVYDMWLTGCKYVVRTANALSRAVNVPTIRKFIKFGMTLVSIPIDL-----LN 2120
Query 2124 GQAAITTSNCAKRLAQR--VFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVK 2181
+ N K + + N++ ++F LLF + + T IA K
Sbjct 2121 LREIKPAVNVVKAVRNKTSACFNFIKWLFVLLFGWIKISADN----KVIYTTEIAS---K 2173
Query 2182 SVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFG-VLLSNFG-APSY 2239
KL A N + K+S + A + + + + I F L G P++
Sbjct 2174 LTCKLVALAFKNAFLTFKWSMVARGACIIATIFLLWFNFIYANVIFSDFYLPKIGFLPTF 2233
Query 2240 CNGVRELYLNSSNVTT-------------MDFCEGSFPCSICLSGLDSLDSYPALETIQV 2286
+ + N+ ++ T +C GS C CL+G D LD+Y A++ +Q
Sbjct 2234 VGKIAQWIKNTFSLVTICDLYSIQDVGFKNQYCNGSIACQFCLAGFDMLDNYKAIDVVQY 2293
Query 2287 TISS--YKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLM 2342
+ +L + E +++Y L+T +FY L +Q+ + F+ ++ W
Sbjct 2294 EADRRAFVDYTGVLKIVIELIVSYALYTAWFYPLFALISIQILTTWLPELFMLSTLHWSF 2353
Query 2343 WFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTT 2402
++++ M P +R YI ASF ++ + H+ GC+ S C+ CYKRNR+ RV+C+T
Sbjct 2354 RLLVALANMLPAHVFMRFYIIIASFIKLFSLFKHVAYGCSKSGCLFCYKRNRSLRVKCST 2413
Query 2403 IVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTD 2462
IV GM R + V ANGG GFC H WNC++CD++ G+TFI+ E A DLS + KRPI PTD
Sbjct 2414 IVGGMIRYYDVMANGGTGFCSKHQWNCIDCDSYKPGNTFITVEAALDLSKELKRPIQPTD 2473
Query 2463 QSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDG 2522
+ + V V ++ L++D+ GQ+ Y+ S FV+ NL + K ++V+V +
Sbjct 2474 VAYHTVTDVKQVGCSMRLFYDRDGQRIYDDVNASLFVDYSNLLHSKVKSVPNMHVVVVEN 2533
Query 2523 KSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVP 2582
+ D++ +A+V+Y+Q + +PIL++D+ L++ T V+ MFD YVDTF + F V
Sbjct 2534 DA--DKANFLNAAVFYAQSLFRPILMVDKNLITTANTGTSVTETMFDVYVDTFLSMFDVD 2591
Query 2583 MEKLKALVATAHSELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLE 2641
+ L AL+ATAHS + +G + VL TF+S AR+ +D+DVDTK + + + + + LE
Sbjct 2592 KKSLNALIATAHSSIKQGTQIYKVLDTFLSCARKSCSIDSDVDTKCLADSVMSAVSAGLE 2651
Query 2642 VTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQ 2701
+T +SCNN + TY K +N+ DLG I +A+H+ VAK VS IW+V + S
Sbjct 2652 LTDESCNNLVPTYLKSDNIVAADLGVLIQNSAKHVQGNVAKIAGVSCIWSVDAFNQFSSD 2711
Query 2702 LRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAA 2761
+ +++ A K + +LT V+V+TT SLKGG + S + +L+C +
Sbjct 2712 FQHKLKKACCKTGLKLKLTYNKQMANVSVLTTPFSLKGGAVFSYFVYVCFVLSLVCFI-- 2769
Query 2762 LVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG- 2820
+ +MP +T+ D YK + +GV RD+ D CFANK FD W+ G
Sbjct 2770 -GLWCLMPTYTVHKSDFQLPVYASYKVLDNGVIRDVSVEDVCFANKFEQFDQWYESTFGL 2828
Query 2821 -SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKL 2879
Y N +CP+V A+I ++ G V +P VLR LHF+ SA G CYTP
Sbjct 2829 SYYSNSMACPIVVAVIDQDFGSTVFNVPTKVLR-YGYHVLHFITHALSADGVQCYTPHSQ 2887
Query 2880 IEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDG-SI 2938
I YS+F S CVL++ CT+F A G P PYCY L++ + YS L P RY L +
Sbjct 2888 ISYSNFYASGCVLSSACTMFTMADGSPQPYCYTDGLMQNASLYSSLVPHVRYNLANAKGF 2947
Query 2939 IQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGV 2998
I+FP EG VRVV T YCR G CE ++ GIC + +G WVLNN++YR+L G FCG
Sbjct 2948 IRFPEVLREGLVRVVRTRSMSYCRVGLCEEADEGICFNFNGSWVLNNDYYRSLPGTFCGR 3007
Query 2999 DAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAAN 3058
D +LI +F L QPV L ++AS +AG I+A++V YY +K +R FG+Y VV N
Sbjct 3008 DVFDLIYQLFKGLAQPVDFLALTASSIAGAILAVIVVLVFYYLIKLKRAFGDYTSVVFVN 3067
Query 3059 ALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWIT 3118
+++ ++F +L + Y L VY++ Y Y T YF +++S + HLQW M+ I+P W
Sbjct 3068 VIVWCVNFMMLFVFQVYPTLSCVYAICYFYATLYFPSEISVIMHLQWLVMYGTIMPLWFC 3127
Query 3119 AIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPL 3178
+Y+ + H W F+ +++ + + TFEE AL TF++ K+ Y KL++ L
Sbjct 3128 LLYIAVVVSNHAFWVFSYC--RKLGTSVRSDGTFEEMALTTFMITKDSYCKLKNS--LSD 3183
Query 3179 TQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDF-SNSGADVLYQPPQTSITSA 3237
+NRYL+LYNKY+Y+SG +DT +YREAAC LAKA++ F +N+G+DVLYQPP S++++
Sbjct 3184 VAFNRYLSLYNKYRYYSGKMDTAAYREAACSQLAKAMDTFTNNNGSDVLYQPPTASVSTS 3243
Query 3238 VLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDL 3297
LQSG KM P+ KVE C+V VT G TLNGLWLDD VYCPRHVIC+A DM NP+Y +L
Sbjct 3244 FLQSGIVKMVNPTSKVEPCVVSVTYGNMTLNGLWLDDKVYCPRHVICSASDMTNPDYTNL 3303
Query 3298 LIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLAC 3357
L R ++ F V + L V+ + M+ C+L L V N +TPKY F ++PG+TF+VLA
Sbjct 3304 LCRVTSSDFTVLFDRLSLTVMSYQMRGCMLVLTVTLQNSRTPKYTFGVVKPGETFTVLAA 3363
Query 3358 YNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDL 3417
YNG P G + MR ++TIKGSFL GSCGSVG+ I DCV F YMH +EL TG H GTD
Sbjct 3364 YNGKPQGAFHVTMRSSYTIKGSFLCGSCGSVGYVIMGDCVKFVYMHQLELSTGCHTGTDF 3423
Query 3418 EGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKY 3477
G FYGP+ D Q Q D ++N LAWLYAA++N WF+ ++ DFN+ A+
Sbjct 3424 NGDFYGPYKDAQVVQLPIQDYIQSVNFLAWLYAAILNNCNWFIQSDKCSVEDFNVWALSN 3483
Query 3478 NYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVV 3537
+ + D V + L++ TG+++ + AA+K L +NG GR I+GS EDE TP DV
Sbjct 3484 GFSQVKSDLV--IDALASMTGVSLETLLAAIKRL-KNGFQGRQIMGSCSFEDELTPSDVY 3540
Query 3538 RQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMA 3597
+Q +G+ Q K ++ KGT W++ + I+ +W++F +V N T +
Sbjct 3541 QQLAGIKLQSKRTRLFKGTVCWIMASTFLFSCIITAFVKWTMFMYVTTN-MFSITFCALC 3599
Query 3598 IAACAMLLVKHKHAFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRL 3656
+ + AMLLVKHKH +L +++ P L T+ Y N +V ++ + WL S+ Y
Sbjct 3600 VISLAMLLVKHKHLYLTMYITPVLFTLLYNNYLVVYKHTFRGYVYAWLSYYVPSVE-YTY 3658
Query 3657 KDCVMYASALVL-LILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVI 3715
D V+Y L++ ++ +T R++ D + + +I++ Y G+ L++ I + ++
Sbjct 3659 TDEVIYGMLLLVGMVFVTLRSINHDLFSFIMFVGRLISVFSLWYKGSNLEEEILL--MLA 3716
Query 3716 SVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFC 3775
S+ Y+ M +A+ I V L F ++ ++L Y F+GY CY+GLF
Sbjct 3717 SLFGTYTWTTVLSMAVAKVIA-KWVAVNVLYFTDIPQIKIVLLCYLFIGYIISCYWGLFS 3775
Query 3776 LLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATV 3835
L+N FR+ LGVY+Y +S QE RYMN+ GL PPK+S +A LN KLLGIGG P I+V+
Sbjct 3776 LMNSLFRMPLGVYNYKISVQELRYMNANGLRPPKNSFEALMLNFKLLGIGGVPIIEVSQF 3835
Query 3836 QSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVL 3895
QSK++DVKC +VVLL+ LQ L V S+SKLW C LHN+IL D + AFEK+ LL VL
Sbjct 3836 QSKLTDVKCANVVLLNCLQHLHVASNSKLWHYCSTLHNEILATSDLSVAFEKLAQLLIVL 3895
Query 3896 LSMQGAVD------INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD 3949
+ AVD I +C++ + LQA+ SEF ++ S+ Y A++ ++A +G
Sbjct 3896 FANPAAVDSKCLTSIEEVCDDYAKDNTVLQALQSEFVNMASFVEYEVAKKNLDEARFSGS 3955
Query 3950 S-EVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQT 4008
+ + LK+L+K+ N+AKS ++RD A+ +KLE+MAD A+T MYK+AR DK++KV SA+QT
Sbjct 3956 ANQQQLKQLEKACNIAKSAYERDRAVAKKLERMADLALTNMYKEARINDKKSKVVSALQT 4015
Query 4009 MLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTY 4068
MLF+M+RKLDN ALN+I++NA GCVPLN IP A L ++VPD Y D TY
Sbjct 4016 MLFSMVRKLDNQALNSILDNAVKGCVPLNAIPSLAANTLNIIVPDKSVYDQIVDNIYVTY 4075
Query 4069 ASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRAN--SAVKLQNNELSPVAL 4126
A +W+IQ + D+D QL+EI S + WPL++ A R N SA LQNNEL P L
Sbjct 4076 AGNVWQIQTIQDSDGTNKQLNEI----SDDCNWPLVIIANRYNEVSATVLQNNELMPAKL 4131
Query 4127 RQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTEL 4186
+ +G QT T YYNNS G+ V A+LSD LK+ + K DG + EL
Sbjct 4132 KIQVVNSGPDQTCNTPTQ--CYYNNSNNGKIVYAILSDVDGLKYTKILKDDGNFVV-LEL 4188
Query 4187 EPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSF 4246
+PPC+F KG K+KYLYF+KG N L RG V+G++++TVRLQAG ATE +NS++LS
Sbjct 4189 DPPCKFTVQDAKGLKIKYLYFVKGCNTLARGWVVGTISSTVRLQAGTATEYASNSSILSL 4248
Query 4247 CAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLY 4306
CAF+VDP K Y D++ GG PI NCVKMLC H GTG AITV P+A Q+S+GGAS C+Y
Sbjct 4249 CAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIY 4308
Query 4307 CRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP 4366
CR ++HP+ G C L+GK+VQ+P DPV + L + VC VCG W+ CSC +
Sbjct 4309 CRARVEHPDVDGLCKLRGKFVQVPVG-IKDPVSYVLTHDVCRVCGFWRDGSCSCVST-DT 4366
Query 4367 LMQSADASTFLN 4378
+QS D + FLN
Sbjct 4367 TVQSKD-TNFLN 4377
Score = 299 bits (765), Expect = 4e-79, Method: Composition-based stats.
Identities = 181/971 (19%), Positives = 329/971 (34%), Gaps = 149/971 (15%)
Query 107 LVPHVGETPIAYRNVLLRKNGNKGA-------GGHSYGIDLKSYDLGDELGTDPIEDYEQ 159
+P I + LRK G KGA GG + D K D D++ +P + +
Sbjct 176 FMPVQSRKFIVPWVMYLRKRGEKGAYNKDHGCGGFGHVYDFKVEDAYDQVHDEPKGKFSK 235
Query 160 NWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYP---LDCIKDFLARAGKSMC-TL 215
L R G YVD C G L+ D + K++ T
Sbjct 236 KAYA---------LIRGYRGVKPLLYVDQYGCDYTGSLADGLEAYADKTLQEMKALFPTW 286
Query 216 SEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKSAK-----KFDTFKGE 269
S++L + + +AW R + Q+ I S D G
Sbjct 287 SQELPF-------------DVIVAWHVVRDPRYVMRLQSAATICSVAYVANPTEDLCDGS 333
Query 270 C----PKFVFPLNSKVKVIQPRVEKKKTEGFMGR--IRSVYPVASPQECNNMHLSTLMKC 323
P V+ +S + + + + Y VA ++C + + C
Sbjct 334 VVIKEPVHVYADDSIILRQYNLFDIMSHFYMEADTVVNAFYGVA-LKDCGFVMQFGYIDC 392
Query 324 --NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVVKMPCPACQDPEIG 379
+ CD W + + CG V + + G LP N V+
Sbjct 393 EQDSCDFKGWIPGNMIDGFACTTCGHVYEVGDLIAQSSGVLPVNPVLHT----------- 441
Query 380 PEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGS----GH 435
S A Y ++ G FGGCV+ R W+P + + S +
Sbjct 442 --KSAAGYGGFGCKDSFTLYGQTVVYFGGCVY----WSPARNIWIPILKSSVKSYDSLVY 495
Query 436 TGITGDNVETLNEDLL---EILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIK 492
TG+ G +L+ L + + L + + + ++
Sbjct 496 TGVLGCKAIVKETNLICKALYLDYVQHKCGNLHQRELLGVSDVWHKQLLINRGVYKPLLE 555
Query 493 SLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIRSIFARTL 552
++DY + + S + V + + R+ + G QA
Sbjct 556 NIDYFNMRRAKFSLETFTVCADGFMPFLLDDLVPRAYYLAVSG---QAFC---------- 602
Query 553 DAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGGLVQQTSQW 612
D A+ + + +LD +D++ L + ++ +A Q
Sbjct 603 DYADKLCHAVVSKSKELLD-------VSLDSLGAAIHYLNSKIVDLA-----------QH 644
Query 613 LSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIK 672
S+ + V K+ F+ L AW + L G + +V+ I NI
Sbjct 645 FSDFGTSFVSKIVHFFKTF-----TTSTALAFAWVLFHVL-HGAYIVVESDIYFV-KNIP 697
Query 673 DCVKCFIDVVNKALEMCIDQVT---IAGAKLRSLNLGEVFIAQSK------GLYRQCIRG 723
++ +D + I G + + ++ K GL
Sbjct 698 RYASAVAQAFQSVAKVVLDSLRVTFIDGLSCFKIGRRRICLSGRKIYEVERGLLHSSQLP 757
Query 724 KEQLQLLMP---LKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG 780
+ L MP KA ++ +L+G D L V + L ++ V
Sbjct 758 LDVYDLTMPSQVQKAKQKPIYLKGSGSDFSLADSVVEVVTTSLTPC-----GYSEPPKVA 812
Query 781 TPVCV-NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGY- 837
+C+ + + + + DK + + + +R+ + VTF E TV E+
Sbjct 813 DKICIVDNVYMAKAGDKYYPVVVDDHVGLLDQAWRVPCAG--RRVTFKEQPTVKEIISMP 870
Query 838 KNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL---LTNM 894
K +++ +ELD + +LN C V+ V+ ++ EF VV +A+ + L P +L +
Sbjct 871 KIIKVFYELDNDFNTILNTACGVFEVDDTVDMEEFYAVVIDAIEEKLSPCKELEGVGAKV 930
Query 895 GIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
L + +LFD+AGEE F+ ++YC+F P +++ ++E+ E E
Sbjct 931 SAFLQKLEDNPLFLFDEAGEEVFAPKLYCAFTAP---------EDDDFLEESDVEEDDVE 981
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPV--NQFTGYLKL 1012
+ L + A V E+EE + L+DT + + EE V + F +
Sbjct 982 GEETDLTIT-SAGQPCVASEQEESSEVLEDTLDDGPSVETSDSQVEEDVEMSDFVDLESV 1040
Query 1013 TDNVAIKCVDI 1023
+ C +
Sbjct 1041 IQDYENVCFEF 1051
Score = 176 bits (447), Expect = 4e-42, Method: Composition-based stats.
Identities = 51/156 (33%), Positives = 81/156 (52%), Gaps = 2/156 (1%)
Query 1011 KLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIK 1070
+T NV DI+K ++ V+VN AN H+ HGGGVA A+ A KE+ + +K
Sbjct 1272 CITPNVCFVKGDIIKVSKLVKAEVVVNPANGHMVHGGGVAKAIAVAAGQQFVKETTNMVK 1331
Query 1071 LNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDILLAPLLS 1128
G G + +G L K L+VVGP+ + LL+ Y++FN+ D ++ L+S
Sbjct 1332 SKGVCATGDCYVSTGGKLCKTVLNVVGPDARTQGKQSYVLLERVYKHFNNYDCVVTTLIS 1391
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
AGIF SL + T + QV + N++ ++ +
Sbjct 1392 AGIFSVPSDVSLTYLLGTAKKQVVLVSNNQEDFDLI 1427
Score = 48.2 bits (113), Expect = 0.003, Method: Composition-based stats.
Identities = 37/150 (25%), Positives = 61/150 (41%), Gaps = 16/150 (11%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
+F +V GL K NNC+L SVL +Q+L +F LQ+ + + + F ++
Sbjct 1057 EFVKVLGLYVPKATRNNCWLRSVLAVMQKLPCQFKDKNLQDLWVLYKQQYSQLFVDTLVN 1116
Query 1694 Y--SNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+N + + G V + L L + V C C L G++A+ + G +
Sbjct 1117 KIPANIVLPQGGYVADFAYWFL---TLCDWQCVAYWKCIKCDL-ALKLKGLDAMFFYGDV 1172
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
VS C CG L+ + F
Sbjct 1173 --------VSHICKCGESMV--LIDVDVPF 1192
>sp|P0C6U3|R1A_CVHN1 Replicase polyprotein 1a OS=Human coronavirus
HKU1 (isolate N1) OX=443239 GN=1a PE=1 SV=1
Length=4471
Score = 3466 bits (8986), Expect = 0.0, Method: Composition-based stats.
Identities = 1059/2942 (36%), Positives = 1590/2942 (54%), Gaps = 112/2942 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1593 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1648
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1649 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1708
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1709 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1767
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1768 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1827
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1828 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1885
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1886 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1943
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1944 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 2002
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 2003 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2060
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2061 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2105
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2106 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2165
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2166 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2224
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2225 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2278
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2279 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2338
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2339 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2394
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2395 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2454
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2455 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2514
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2515 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2574
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2575 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2632
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2633 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2692
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2693 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2752
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2753 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDAFNQLTADLQHKLKKACVKTG 2812
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2813 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFVSLICFI---LLWALLPTYSVY 2869
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2870 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2929
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2930 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2988
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2989 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3048
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3049 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3108
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3109 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLMLFV 3168
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3169 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3228
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3229 WLFSYC--RKIGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3284
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3285 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3344
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC++ +M P+Y LL R + F + +
Sbjct 3345 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMNEPDYSALLCRVTLGDFTIMS 3404
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3405 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGNVKPGETFTVLAAYNGRPQGAFHVTM 3464
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3465 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3524
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ + DFN+ AM + + D V L
Sbjct 3525 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLV--L 3582
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3583 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3641
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3642 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3700
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3701 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSYFVPAVNFTYVYEVFYGCILCVFA 3760
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3761 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3818
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3819 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3877
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3878 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3937
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3938 LNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKCLAS 3997
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3998 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4057
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4058 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4117
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPL+ IP A L +V+PD + D TYA ++W IQ V DAD
Sbjct 4118 NSILDNAVKGCVPLSAIPALAANTLTIVIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDAD 4177
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4178 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDMNCN 4233
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4234 IPTQ--CYYNNGSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDVKGL 4290
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4291 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4350
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4351 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGIC 4410
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF 4380
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLNGF
Sbjct 4411 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKDL-NFLNGF 4467
Query 4381 AV 4382
V
Sbjct 4468 GV 4469
Score = 308 bits (790), Expect = 4e-82, Method: Composition-based stats.
Identities = 160/909 (18%), Positives = 309/909 (34%), Gaps = 167/909 (18%)
Query 141 KSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDC 200
+D D D + K+ A L R+ G +VD C G DC
Sbjct 185 FKFDDYDFSVEDAYAEVHAEPKGKYSQKAYA-LLRQYRGIKPVLFVDQYGCDYSGKLADC 243
Query 201 IKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKS 259
A S+ + ++ + +AW R + QT I
Sbjct 244 ---LQAYGHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICG 294
Query 260 AK-----KFDTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQ 310
K D G+ P + ++ V + P + K T I+S+Y V
Sbjct 295 IKYVAQPTEDVVDGDVVIREPVHLLSADAIVLKL-PSLMKVMTHMDDFSIKSIYNVD-LC 352
Query 311 ECNNMHLSTLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVV 366
+C + + C ++CD W + + + C T E + G +P N V+
Sbjct 353 DCGFVMQYGYVDCFNDNCDFYGWVSGNMMDGFSCPLCCTVYDSSEVKAQSSGVIPENPVL 412
Query 367 KMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPR 426
+ H + + +S FG C++ + W+P
Sbjct 413 FT------NSTDTVNHDSFNLYGYSVTP-----------FGSCIY----WSPRPGLWIPI 451
Query 427 ASADI-------GSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILAS 479
+ + SG G ET L + G+ N +
Sbjct 452 IKSSVKSYDDLVYSGVVGCKSIVKETALITHALYLDYVQCK---CGNLEQNHIL------ 502
Query 480 FSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQ 539
++ + ++ + G+Y + NI F +
Sbjct 503 -------------GVNNSWCRQLLLNRGDYNMLLK-------NIDLFVKRRA---DFACK 539
Query 540 AAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYT-------SDLLT 592
A + +LDG+ +S L+ + ++ S ++
Sbjct 540 FA-----VCGDGF-------------VPFLLDGLIPRSYYLIQSGIFFTSLMSQFSQEVS 581
Query 593 NSVIIMAYVTGGLVQQTSQWLSNLLGTTVEK--------LRPIFEWIEAKLSAGVEFLKD 644
+ + M + V + ++ + + V + + + W L A
Sbjct 582 DMCLKMCILFMDRVSVATFYIEHYVNRLVTQFKLLGTTLVNKMVNWFNTMLDASAP--AT 639
Query 645 AWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----L 700
W + + L+ G+F + + + I D K ++ ++ ++ VT+ K L
Sbjct 640 GWLLYQ-LLNGLFVVSQANFNFVA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVL 697
Query 701 RSLN-----LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSE 754
+++N +G F S GL ++P A +++ F EG +E
Sbjct 698 KTINGLVCIVGNKFYNVSTGLI---------PGFVLPCNAQEQQIYFFEG-------VAE 741
Query 755 EVVLKNGELEALETPVDSFT---NGAIVGTPVCVNGLMLLEIKDKEQYCALSPG---LLA 808
V++++ +E +++ + S+ V ++ + + + DK ++ LL
Sbjct 742 SVIVEDDVIENVKSSLSSYEYCQPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLD 801
Query 809 TNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGT 867
F G + V F E V E+ V++ F+LD D +L + CS + VE G
Sbjct 802 QAWRFPCAG----RKVNFNEKPVVMEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGV 857
Query 868 EVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCS 924
V +F VV +A+ L + + + L++ + YLFD+AG+E +SRMYC+
Sbjct 858 TVDDFVAVVCDAIENALNSCKEHPVVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCT 917
Query 925 FYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDD 984
F D E+ +E E+ ID E ++D + E V + ++ED +
Sbjct 918 FAIEDVEDVISSEAVEDTIDGVVEDTINDDEDVVTGDND----DEDVVTGDNDDEDVVTG 973
Query 985 TTEQSEIEP 993
+ ++
Sbjct 974 DNDDEDVVT 982
Score = 174 bits (442), Expect = 1e-41, Method: Composition-based stats.
Identities = 55/162 (34%), Positives = 79/162 (49%), Gaps = 2/162 (1%)
Query 1005 QFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE 1064
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE
Sbjct 1353 PQLYGLCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKE 1412
Query 1065 SDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDIL 1122
+ +K G VG + +G L K L++VGP+ + LL AY++ N+ D
Sbjct 1413 TAAMVKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCC 1472
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L+ L+SAGIF SL + V QV + N+K ++ +
Sbjct 1473 LSTLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1514
Score = 50.1 bits (118), Expect = 8e-04, Method: Composition-based stats.
Identities = 44/177 (25%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query 1601 DDTLRSEAFEYYHTL----DESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSV 1656
DD F+ Y L D ++S + + + +V GL S NC+L SV
Sbjct 1107 DDIESIYDFDTYKALLVFNDVYNDALFVSYGSSVETETYFKVNGLWSPTITHTNCWLRSV 1166
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQ 1714
LL +Q+L KF A++ + + G +F +L K + G V + L
Sbjct 1167 LLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIPKAIVLPQGGFVADFAYWFLN 1226
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ N C CG + L G++A+ + G + VS C CG + T
Sbjct 1227 QFDI---NAYANWCCLKCGF-SFDLNGLDALFFYGDI--------VSHVCKCGHNMT 1271
Score = 48.2 bits (113), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1362 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1416
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1417 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1474
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1475 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1510
>sp|P0C6X2|R1AB_CVHN1 Replicase polyprotein 1ab OS=Human coronavirus
HKU1 (isolate N1) OX=443239 GN=rep PE=3 SV=1
Length=7182
Score = 3464 bits (8981), Expect = 0.0, Method: Composition-based stats.
Identities = 1056/2938 (36%), Positives = 1587/2938 (54%), Gaps = 112/2938 (4%)
Query 1488 RDWSYSGQ----RTELGVEFLKRGDKIVYHTLESPVEFHLDGEV--LSLDKLKSLLSLRE 1541
+DW + V++ + + I + + DG +++++ LL
Sbjct 1593 KDWRLINKFDVINGVKTVKYFECPNSIYICSQGKDFGYVCDGSFYKATVNQVCVLL---- 1648
Query 1542 VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSD 1601
K I V TVD N + + + +G+ G + DG DVTK+K + K + +
Sbjct 1649 AKKIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADKILYQYENL 1708
Query 1602 DTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQ 1661
A + D+ L Y + L KW G S + + NNCY++ L LQ
Sbjct 1709 SLADISAVQSSFGFDQQQLLAYYNFL-TVCKWSVVVNGPFFSFEQSHNNCYVNVACLMLQ 1767
Query 1662 QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESA 1721
+ +KFN QEA+Y RAG AL+LA + E D + + +L+ A+L A
Sbjct 1768 HINLKFNKWQWQEAWYEFRAGRPHRLVALVLAKGHFKFDEPSDATDFIRVVLKQADLSGA 1827
Query 1722 KRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF 1781
L ++C CG K + GV+AVM+ GTL+ +L G I C C + + F
Sbjct 1828 ICELELICD-CGIKQESRVGVDAVMHFGTLAKTDLFNGYKIGCNCAG-RIVHCTKLNVPF 1885
Query 1782 VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT 1841
++ S P L + AN + G GHYTH+ D + K + G +T
Sbjct 1886 LICSNTPLSKDLPDDV-VAANMFMG-VGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLT 1943
Query 1842 DVFY-KETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP-- 1898
D Y K + T T +Y LD V P L YY + YYT +PI +P
Sbjct 1944 DCLYLKNLTQTFTSMLTNYFLDDVEMVAYNPDLSQYYCDNGKYYT-KPIIKAQFKPFAKV 2002
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKP-ASRELSVTFFPDLNGDVVAIDYRHYSASFK 1957
+ + NFKL LN GF E VT +P GDVV Y +
Sbjct 2003 DGVYTNFKLV--GHDICAQLNDKLGFNVDLPFVEYKVTVWPVATGDVVLASDDLYVKRYF 2060
Query 1958 KGAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKP-VDTSNSFEVLAVEDTQGMDNL 2016
KG + KP++W + + + + KP + N + VL+V D++
Sbjct 2061 KGCETFGKPVIWFCHDEASLNSLT---------YFNKPSFKSENRYSVLSV------DSV 2105
Query 2017 ACESQQPTSEEVVENPTIQKEV-IECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAA 2075
+ ESQ V+E+ KEV ++ KT ++ +I+ + +KV + L D+
Sbjct 2106 SEESQGNVVTSVMESQISTKEVKLKGVRKTVKIEDAIIVNDENSSIKVVKSLSLVDVWDM 2165
Query 2076 YVENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAK 2135
Y+ + NELS + T+ + I + L ++ Q +
Sbjct 2166 YLTGCDYVVWVANELSRLVKSPTVREYIRYGIKPITIPIDLLCLRD-DNQTLLVPKIFKA 2224
Query 2136 RLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYV 2195
R + F ++ ++F +F L FT T IA ++ L L
Sbjct 2225 RAIE--FYGFLKWLFIYVFSLLHFTNDKT----IFYTTEIASKFTFNLFCLALKNAFQTF 2278
Query 2196 KSPKFSK-------LFTIAMWLLLLSICLGSL---------ICVTAAFGVLLSNFGAPSY 2239
+ F K +F L +++ I V + + FG +
Sbjct 2279 RWSIFIKGFLVVATVFLFWFNFLYINVIFSDFYLPNISVFPIFVGRIVMWIKATFGLVTI 2338
Query 2240 CNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLD--LTI 2297
C+ +L + T FC GSF C +C SG D LD+Y A++ +Q + L +++
Sbjct 2339 CDFYSKLGVG----FTSHFCNGSFICELCHSGFDMLDTYAAIDFVQYEVDRRVLFDYVSL 2394
Query 2298 LGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNS--WLMWFIISIVQMAPVS 2355
+ L E V+ Y L+T +FY L +Q+F + F+ + WL+ FI+ + M P
Sbjct 2395 VKLIVELVIGYSLYTVWFYPLFCLIGLQLFTTWLPDLFMLETMHWLIRFIVFVANMLPAF 2454
Query 2356 AMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYA 2415
++R YI + Y + HI+ GC + C+ CYKRN + RV+C+TIV G+ R + + A
Sbjct 2455 VLLRFYIVVTAMYKVVGFIRHIVYGCNKAGCLFCYKRNCSVRVKCSTIVGGVIRYYDITA 2514
Query 2416 NGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKN 2475
NGG GFC H WNC NC +F G+TFI+ E A +LS + KRP+NPTD S Y+V +
Sbjct 2515 NGGTGFCVKHQWNCFNCHSFKPGNTFITVEAAIELSKELKRPVNPTDASHYVVTDIKQVG 2574
Query 2476 GALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSAS 2535
+ L++D+ GQ+ Y+ S FV+++NL + K + V+V + + D + +A
Sbjct 2575 CMMRLFYDRDGQRVYDDVDASLFVDINNLLHSKVKVVPNLYVVVVESDA--DRANFLNAV 2632
Query 2536 VYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHS 2595
V+Y+Q + +PILL+D+ L++ + V+ MFD YVDTF + F V + V AH+
Sbjct 2633 VFYAQSLYRPILLVDKKLITTACNGISVTQTMFDVYVDTFMSHFDVDRKSFNNFVNIAHA 2692
Query 2596 ELAKGVALDGVLSTFVSAARQGV-VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTY 2654
L +GV L+ VL TFV R+ +D+DV+T+ + + + + + LE T ++ NN + TY
Sbjct 2693 SLREGVQLEKVLDTFVGCVRKCCSIDSDVETRFITKSMISAVAAGLEFTDENYNNLVPTY 2752
Query 2655 NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNN 2714
K +N+ DLG I A+H+ VAK+ N+S IW + + L+ L+ +++ A K
Sbjct 2753 LKSDNIVAADLGVLIQNGAKHVQGNVAKAANISCIWFIDAFNQLTADLQHKLKKACVKTG 2812
Query 2715 IPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLS 2774
+ +LT V ++TT SLKGG ++S ++ +L+C + + + ++P +++
Sbjct 2813 LKLKLTFNKQEASVPILTTPFSLKGGVVLSNLLYILFFVSLICFI---LLWALLPTYSVY 2869
Query 2775 IHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG--SYKNDKSCPVVA 2832
D + +K I +GV RDI D CFANK FD W+ G Y N CP+V
Sbjct 2870 KSDIHLPAYASFKVIDNGVVRDISVNDLCFANKFFQFDQWYESTFGSVYYHNSMDCPIVV 2929
Query 2833 AIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVL 2892
A++ +IG + +P VLR LHFL F++ CYTP I Y+DF S CVL
Sbjct 2930 AVMDEDIGSTMFNVPTKVLRH-GFHVLHFLTYAFASDSVQCYTPHIQISYNDFYASGCVL 2988
Query 2893 AAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGS-IIQFPNTYLEGSVR 2951
++ CT+FK G P PYCY +++ + Y+ L P TRY L + + I+FP+ EG VR
Sbjct 2989 SSLCTMFKRGDGTPHPYCYSDGVMKNASLYTSLVPHTRYSLANSNGFIRFPDVISEGIVR 3048
Query 2952 VVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPL 3011
+V T YCR G CE +E GIC + + WVLNN++YR++ G FCG D +L F+ L
Sbjct 3049 IVRTRSMTYCRVGACEYAEEGICFNFNSSWVLNNDYYRSMPGTFCGRDLFDLFYQFFSSL 3108
Query 3012 VQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCL 3071
++P+ ++AS + G I+AI+V YY +K +R FG+Y VV N +++ ++F +L +
Sbjct 3109 IRPIDFFSLTASSIFGAILAIVVVLVFYYLIKLKRAFGDYTSVVVINVVVWCINFLMLFV 3168
Query 3072 VPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCH 3131
Y VY+ FY Y+T YF +++S + HLQW M+ I+PFW YV + H
Sbjct 3169 FQVYPICACVYACFYFYVTLYFPSEISVIMHLQWIVMYGAIMPFWFCVTYVAMVIANHVL 3228
Query 3132 WFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKY 3191
W F+ +++ N + STFEE +L TF++ K+ Y +L++ + YNRYL+LYNKY
Sbjct 3229 WLFSYC--RKIGVNVCSDSTFEETSLTTFMITKDSYCRLKNS--VSDVAYNRYLSLYNKY 3284
Query 3192 KYFSGALDTTSYREAACCHLAKALNDFS-NSGADVLYQPPQTSITSAVLQSGFRKMAFPS 3250
+Y+SG +DT +YREAAC LAKA+ F+ N+G DVLYQPP S++++ LQSG KM P+
Sbjct 3285 RYYSGKMDTAAYREAACSQLAKAMETFNHNNGNDVLYQPPTASVSTSFLQSGIVKMVSPT 3344
Query 3251 GKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQA 3310
K+E C+V VT G+ TLNGLWLDD VYCPRHVIC++ +M P+Y LL R + F + +
Sbjct 3345 SKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMNEPDYSALLCRVTLGDFTIMS 3404
Query 3311 GNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAM 3370
G + L V+ + MQ C L L V NP TPKY F ++PG+TF+VLA YNG P G + M
Sbjct 3405 GRMSLTVVSYQMQGCQLVLTVSLQNPYTPKYTFGNVKPGETFTVLAAYNGRPQGAFHVTM 3464
Query 3371 RPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQT 3430
R ++TIKGSFL GSCGSVG+ + D V F YMH +EL TG H GTD G FYGP+ D Q
Sbjct 3465 RSSYTIKGSFLCGSCGSVGYVLTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQV 3524
Query 3431 AQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL 3490
Q D T+NV+AWLYAA++N WF+ + DFN+ AM + + D V L
Sbjct 3525 VQLPVKDYVQTVNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLV--L 3582
Query 3491 GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFK 3550
L++ TG+++ + AA+K L G GR ILGS EDE P DV +Q +GV Q K K
Sbjct 3583 DALASMTGVSIETLLAAIKRLYM-GFQGRQILGSCTFEDELAPSDVYQQLAGVKLQSKTK 3641
Query 3551 KIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKH 3610
+ +K T +W+L++ I+ +W++F ++ + + TL ++ + MLLVKHKH
Sbjct 3642 RFIKETIYWILISTFLFSCIISAFVKWTIFMYINTH-MIGVTLCVLCFVSFMMLLVKHKH 3700
Query 3611 AFLCLFLLPSLATVAYFN-MVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
+L ++++P L T+ Y N +V + WL +++ + + V
Sbjct 3701 FYLTMYIIPVLCTLFYVNYLVVYKEGFRGFTYVWLSYFVPAVNFTYVYEVFYGCILCVFA 3760
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
I +T ++ D ++ + ++TL+ Y+G+ L++ + ++ + + Y+ +
Sbjct 3761 IFITMHSINHDIFSLMFLVGRIVTLISMWYFGSNLEEDVLLF--ITAFLGTYTWTTILSL 3818
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A+ IV + F ++ I+L Y F+GY CY+G F LLN FR+ +GVY+
Sbjct 3819 AIAK-IVANWLSVNIFYFTDVPYIKLILLSYLFIGYILSCYWGFFSLLNSVFRMPMGVYN 3877
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
Y +S QE RYMN+ GL PP++S +A LN+KLLGIGG P I+V+ +QSK++DVKC +VVL
Sbjct 3878 YKISVQELRYMNANGLRPPRNSFEAILLNLKLLGIGGVPVIEVSQIQSKLTDVKCANVVL 3937
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------ 3903
L+ LQ L V S+SKLW C LHN+IL D + AF+K+ LL VL + AVD
Sbjct 3938 LNCLQHLHVASNSKLWQYCSVLHNEILSTSDLSVAFDKLAQLLIVLFANPAAVDTKCLAS 3997
Query 3904 INRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGD-SEVVLKKLKKSLN 3962
I+ + ++ + + LQA+ SEF ++ S+ Y A++ A +G ++ +K+L+K+ N
Sbjct 3998 IDEVSDDYVQDSTVLQALQSEFVNMASFVEYEVAKKNLADAKNSGSVNQQQIKQLEKACN 4057
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS ++RD A+ RKLE+MAD A+T MYK+AR DK++KV SA+QTMLF+M+RKLDN AL
Sbjct 4058 IAKSVYERDKAVARKLERMADLALTNMYKEARINDKKSKVVSALQTMLFSMVRKLDNQAL 4117
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N+I++NA GCVPL+ IP A L +V+PD + D TYA ++W IQ V DAD
Sbjct 4118 NSILDNAVKGCVPLSAIPALAANTLTIVIPDKQVFDKVVDNVYVTYAGSVWHIQTVQDAD 4177
Query 4083 SKIVQLSEINMDNSPNLAWPLIVTALRANS--AVKLQNNELSPVALRQMSCAAGTTQTAC 4140
QL++I++D++ WPL++ A R N +QNNEL P L+ +G+
Sbjct 4178 GINKQLTDISVDSN----WPLVIIANRYNEVANAVMQNNELMPHKLKIQVVNSGSDMNCN 4233
Query 4141 TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP 4200
YYNN GR V A+LSD LK+ + K DG + EL+PPC+F KG
Sbjct 4234 IPTQ--CYYNNGSSGRIVYAVLSDVDGLKYTKIMKDDGNCVV-LELDPPCKFSIQDVKGL 4290
Query 4201 KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY 4260
K+KYLYFIKG N L RG V+G+L++T+RLQAG ATE ANS++LS CAF+VDP K Y DY
Sbjct 4291 KIKYLYFIKGCNTLARGWVVGTLSSTIRLQAGVATEYAANSSILSLCAFSVDPKKTYLDY 4350
Query 4261 LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC 4320
+ GG PI NCVKMLC H GTG AIT+ PEA ++Q+S+GGAS C+YCR ++HP+ G C
Sbjct 4351 IQQGGVPIINCVKMLCDHAGTGMAITIKPEATINQDSYGGASVCIYCRARVEHPDVDGIC 4410
Query 4321 DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
L+GK+VQ+P DP+ + L + VC VCG W+ CSC +QS D FLN
Sbjct 4411 KLRGKFVQVPLG-IKDPILYVLTHDVCQVCGFWRDGSCSCVG-SSVAVQSKDL-NFLN 4465
Score = 310 bits (793), Expect = 2e-82, Method: Composition-based stats.
Identities = 160/909 (18%), Positives = 309/909 (34%), Gaps = 167/909 (18%)
Query 141 KSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGGAVTRYVDNNFCGPDGYPLDC 200
+D D D + K+ A L R+ G +VD C G DC
Sbjct 185 FKFDDYDFSVEDAYAEVHAEPKGKYSQKAYA-LLRQYRGIKPVLFVDQYGCDYSGKLADC 243
Query 201 IKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTERSDKSYEH-QTPFEIKS 259
A S+ + ++ + +AW R + QT I
Sbjct 244 ---LQAYGHYSLQDMRQKQSVWLANCDFDIV------VAWHVVRDSRFVMRLQTIATICG 294
Query 260 AK-----KFDTFKGEC----PKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVYPVASPQ 310
K D G+ P + ++ V + P + K T I+S+Y V
Sbjct 295 IKYVAQPTEDVVDGDVVIREPVHLLSADAIVLKL-PSLMKVMTHMDDFSIKSIYNVD-LC 352
Query 311 ECNNMHLSTLMKC--NHCDEVSWQTCDFLKATCE-HCGTENLVIEG-PTTCGYLPTNAVV 366
+C + + C ++CD W + + + C T E + G +P N V+
Sbjct 353 DCGFVMQYGYVDCFNDNCDFYGWVSGNMMDGFSCPLCCTVYDSSEVKAQSSGVIPENPVL 412
Query 367 KMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPR 426
+ H + + +S FG C++ + W+P
Sbjct 413 FT------NSTDTVNHDSFNLYGYSVTP-----------FGSCIY----WSPRPGLWIPI 451
Query 427 ASADI-------GSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILAS 479
+ + SG G ET L + G+ N +
Sbjct 452 IKSSVKSYDDLVYSGVVGCKSIVKETALITHALYLDYVQCK---CGNLEQNHIL------ 502
Query 480 FSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQ 539
++ + ++ + G+Y + NI F +
Sbjct 503 -------------GVNNSWCRQLLLNRGDYNMLLK-------NIDLFVKRRA---DFACK 539
Query 540 AAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYT-------SDLLT 592
A + +LDG+ +S L+ + ++ S ++
Sbjct 540 FA-----VCGDGF-------------VPFLLDGLIPRSYYLIQSGIFFTSLMSQFSQEVS 581
Query 593 NSVIIMAYVTGGLVQQTSQWLSNLLGTTVEK--------LRPIFEWIEAKLSAGVEFLKD 644
+ + M + V + ++ + + V + + + W L A
Sbjct 582 DMCLKMCILFMDRVSVATFYIEHYVNRLVTQFKLLGTTLVNKMVNWFNTMLDASAP--AT 639
Query 645 AWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAK----L 700
W + + L+ G+F + + + I D K ++ ++ ++ VT+ K L
Sbjct 640 GWLLYQ-LLNGLFVVSQANFNFVA-LIPDYAKILVNKFYTFFKLLLECVTVDVLKDMPVL 697
Query 701 RSLN-----LGEVFIAQSKGLYRQCIRGKEQLQLLMPLKA-PKEVTFLEGDSHDTVLTSE 754
+++N +G F S GL ++P A +++ F EG +E
Sbjct 698 KTINGLVCIVGNKFYNVSTGLI---------PGFVLPCNAQEQQIYFFEG-------VAE 741
Query 755 EVVLKNGELEALETPVDSFT---NGAIVGTPVCVNGLMLLEIKDKEQYCALSPG---LLA 808
V++++ +E +++ + S+ V ++ + + + DK ++ LL
Sbjct 742 SVIVEDDVIENVKSSLSSYEYCQPPKSVEKICIIDNMYMGKCGDKFFPIVMNDKNICLLD 801
Query 809 TNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGT 867
F G + V F E V E+ V++ F+LD D +L + CS + VE G
Sbjct 802 QAWRFPCAG----RKVNFNEKPVVMEIPSLMTVKVMFDLDSTFDDILGKVCSEFEVEKGV 857
Query 868 EVTEFACVVAEAVVKTLQPVSD---LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCS 924
V +F VV +A+ L + + + L++ + YLFD+AG+E +SRMYC+
Sbjct 858 TVDDFVAVVCDAIENALNSCKEHPVVGYQVRAFLNKLNENVVYLFDEAGDEAMASRMYCT 917
Query 925 FYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDD 984
F D E+ +E E+ ID E ++D + E V + ++ED +
Sbjct 918 FAIEDVEDVISSEAVEDTIDGVVEDTINDDEDVVTGDND----DEDVVTGDNDDEDVVTG 973
Query 985 TTEQSEIEP 993
+ ++
Sbjct 974 DNDDEDVVT 982
Score = 175 bits (443), Expect = 1e-41, Method: Composition-based stats.
Identities = 55/162 (34%), Positives = 79/162 (49%), Gaps = 2/162 (1%)
Query 1005 QFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE 1064
L +T NV DI+ A+ VIVN AN H+ HGGGVA A+ A KE
Sbjct 1353 PQLYGLCITPNVCFVKGDIINVARLVKADVIVNPANGHMLHGGGVAKAIAVAAGKKFSKE 1412
Query 1065 SDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLN--AGEDIQLLKAAYENFNSQDIL 1122
+ +K G VG + +G L K L++VGP+ + LL AY++ N+ D
Sbjct 1413 TAAMVKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKHLNNYDCC 1472
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L+ L+SAGIF SL + V QV + N+K ++ +
Sbjct 1473 LSTLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKEDFDII 1514
Score = 50.1 bits (118), Expect = 7e-04, Method: Composition-based stats.
Identities = 44/177 (25%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query 1601 DDTLRSEAFEYYHTL----DESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSV 1656
DD F+ Y L D ++S + + + +V GL S NC+L SV
Sbjct 1107 DDIESIYDFDTYKALLVFNDVYNDALFVSYGSSVETETYFKVNGLWSPTITHTNCWLRSV 1166
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGEL--GDVRETMTHLLQ 1714
LL +Q+L KF A++ + + G +F +L K + G V + L
Sbjct 1167 LLVMQKLPFKFKDLAIENMWLSYKVGYNQSFVDYLLTTIPKAIVLPQGGFVADFAYWFLN 1226
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDAT 1771
++ N C CG + L G++A+ + G + VS C CG + T
Sbjct 1227 QFDI---NAYANWCCLKCGF-SFDLNGLDALFFYGDI--------VSHVCKCGHNMT 1271
Score = 48.6 bits (114), Expect = 0.002, Method: Composition-based stats.
Identities = 25/156 (16%), Positives = 46/156 (29%), Gaps = 15/156 (10%)
Query 1195 KSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSF 1254
+V D+ + +V L + + + E +
Sbjct 1362 PNVCFVKGDIINVARLVKADVIVNPANGHMLHG-----GGVAKAIAVAAGKKFSKETAAM 1416
Query 1255 LEKDAPYMVGDV-ITSG-----DITCVVIPSKKAGGTTE--MLSRALKKVPVDEYITTYP 1306
++ VGD +++G I +V P + G +L+RA K ++ Y
Sbjct 1417 VKSKGVCQVGDCYVSTGGKLCKTILNIVGPDARQDGRQSYVLLARAYKH--LNNYDCCLS 1474
Query 1307 GQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEE 1342
AG A +L N KE+
Sbjct 1475 TLISAGIFSVPADVSLTYLLGVVDKQVILVSNNKED 1510
>sp|P0C6X5|R1AB_CVHNL Replicase polyprotein 1ab OS=Human coronavirus
NL63 OX=277944 GN=rep PE=1 SV=1
Length=6729
Score = 2614 bits (6776), Expect = 0.0, Method: Composition-based stats.
Identities = 760/2298 (33%), Positives = 1183/2298 (51%), Gaps = 119/2298 (5%)
Query 2096 LKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQ 2155
L T+A I + S + P + I+ + AQ+ F + +V +
Sbjct 1858 LSTLAVTAIVVVGGCVTSNV-----PTIVSEKISVMDKLDTGAQKFFQ-FGDFVMNNIVL 1911
Query 2156 LCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKF---SKLFTIAM-WLL 2211
T+ S S +R T+I K+ +K +AK G+ +S K+ S LF I W +
Sbjct 1912 FLTWLLSMFSLLR----TSIMKHDIKVIAKAPKRTGVILTRSFKYNIRSALFVIKQKWCV 1967
Query 2212 LLSICLGSLICVTAAFGVLLSNFGAPS---YCNGVRELYLNSSNVTTMDFCEGSFPCSIC 2268
++++ L+ V + +P C + Y S+ + +C S C +C
Sbjct 1968 IVTLFKFLLLLYAIYALVFMIVQFSPFNSLLCGDIVSGYEKSTFNKDI-YCGNSMVCKMC 2026
Query 2269 LSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML-FTKFFYLLGLSAIMQVF 2327
L + + I D ++ L +L +L F + GL + F
Sbjct 2027 LFSYQEFNDLDHTSLVWKHIR----DPILISLQPFVILVILLIFGNMYLRFGLLYFVAQF 2082
Query 2328 FGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCM 2387
F S F+ WF+ P + ++ I HI+ GC ++ C+
Sbjct 2083 ISTFGS-FLGFHQKQWFL----HFVPFDVLCNEFLATFIVCKIVLFVRHIIVGCNNADCV 2137
Query 2388 MCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVA 2447
C K R RV TI+NGM +SFYV ANGG FC HN+ C+NCD+F G+TFI+ ++A
Sbjct 2138 ACSKSARLKRVPLQTIINGMHKSFYVNANGGTCFCNKHNFFCVNCDSFGPGNTFINGDIA 2197
Query 2448 RDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRAN 2507
R+L K + PT + I+D V NG LY + S + + L+
Sbjct 2198 RELGNVVKTAVQPTAPAYVIIDKVDFVNGFYRLYSGDTFWRYDFDITESKYSCKEVLKNC 2257
Query 2508 NTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKM 2567
N N IV++ S + + K+A VY+SQL+C+PI L++ L+S + S + + +
Sbjct 2258 NV----LENFIVYNN-SGSNITQIKNACVYFSQLLCEPIKLVNSELLSTL--SVDFNGVL 2310
Query 2568 FDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD 2627
AYVD +F ++L A ++ A + G+ V D
Sbjct 2311 HKAYVDVLCNSF---FKELTANMSMAECKATLGLT--------------------VSDDD 2347
Query 2628 VIECLKLSHHSDLEVTGDSCNNFMLTYNKV-ENMTPRDLGACIDCNARHINAQVAKSHNV 2686
+ + +H D+ ++ S NNF ++Y K + ++ D+ C+ ++ +N V ++
Sbjct 2348 FVSAVANAHRYDVLLSDLSFNNFFISYAKPEDKLSVYDIACCMRAGSKVVNHNVLIKESI 2407
Query 2687 SLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTC 2746
++W VKD+ +LS++ +K + K + F LT + + V T I K G
Sbjct 2408 PIVWGVKDFNTLSQEGKKYLVKTTKAKGLTFLLTFNDNQAITQVPATSIVAKQGAGFKRT 2467
Query 2747 FKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFAN 2806
+ + L V + + T++ GY +K I++G + + C N
Sbjct 2468 YNFLWYVCLFVVALFIGVSFIDYTTTVTSFHGY-----DFKYIENGQLKVFEAPLHCVRN 2522
Query 2807 KHAGFDAWFSQRGGSYK-NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRV 2865
F+ W + G N CP+V + R +VPG+P V + G L F +
Sbjct 2523 VFDNFNQWHEAKFGVVTTNSDKCPIVVGVSERI--NVVPGVPTNVY--LVGKTLVFTLQA 2578
Query 2866 FSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSEL 2925
+CY + C+ + CT + G V YCY+T+L+EGS YS L
Sbjct 2579 AFGNTGVCYDFDGVTTSD-----KCIFNSACTRLEGLGGDNV-YCYNTDLIEGSKPYSTL 2632
Query 2926 RPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLN 2984
+P+ Y + ++FP G +R + T YCR G C S G+C +W +N
Sbjct 2633 QPNAYYKYDAKNYVRFPEILARGFGLRTIRTLATRYCRVGECRDSHKGVCFGFD-KWYVN 2691
Query 2985 NEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKF 3044
+ R G CG ++L+ N+ + + +S ++ + A +T + KF
Sbjct 2692 DG--RVDDGYICGDGLIDLLVNVLSIFSSSFSVVAMSGHMLFNFLFAAFITFLCFLVTKF 2749
Query 3045 RRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDV--SFLAH 3102
+RVFG+ ++ V L++ I +V F +Y++ Y F FT V +++ H
Sbjct 2750 KRVFGDLSYGVFTVVCATLIN-NISYVVTQNLFFMLLYAILY----FVFTRTVRYAWIWH 2804
Query 3103 LQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFL 3161
+ + + ++P+W+ + F L+ F + + +F G F TFE AA TF+
Sbjct 2805 IAYIVAYFLLIPWWLLTWFSFAAFLELLPNVFKLKISTQ-LFEGDKFIGTFESAAAGTFV 2863
Query 3162 LNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS 3221
L+ Y +L + + + Y A YNKYKY+SG+ YR A HLAKA+ D++
Sbjct 2864 LDMRSYERLINT--ISPEKLKNYAASYNKYKYYSGSASEADYRCACYAHLAKAMLDYAKD 2921
Query 3222 GADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRH 3281
D+LY PP S S LQSG +KMA PSG VE C+V+V G+T LNG+WL DTV CPRH
Sbjct 2922 HNDMLYSPPTISYNST-LQSGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRH 2980
Query 3282 VICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
VI + +L +Y+ H+F V V L V+G +M +LR+KV SN TPK+
Sbjct 2981 VIAPSTTVL-IDYDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHTPKH 3039
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYD-CVSFC 3400
F ++PG +F++LACY G SGV+ +R N TIKGSF+NG+CGS G+N+ D V FC
Sbjct 3040 VFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSPGYNVRNDGTVEFC 3099
Query 3401 YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFL 3460
Y+H +EL +G H G+D G YG F D+ + Q + ++ NV+A+LYAA++NG RW+L
Sbjct 3100 YLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLMLSDNVVAFLYAALLNGCRWWL 3159
Query 3461 NRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT 3520
++ FN AM Y ++ V+ L+A+TG++V + A+++ L G G+
Sbjct 3160 CSTRVNVDGFNEWAMANGYTSVSS--VECYSILAAKTGVSVEQLLASIQHL-HEGFGGKN 3216
Query 3521 ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLF 3580
ILG + L DEFT +VV+Q GV Q K++ G L + ++ ++
Sbjct 3217 ILGYSSLCDEFTLAEVVKQMYGVNLQSG--KVIFGLKTMFLFSVFFTMFWAELFI-YTNT 3273
Query 3581 FFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRI 3640
++ P ++ ++ + +KHK FL +FLLP++ A +N V ++++
Sbjct 3274 IWINPVILTPIFCLLLFLSLVLTMFLKHKFLFLQVFLLPTVIATALYNCVLD--YYIVKF 3331
Query 3641 MTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYY 3700
+ + S+ ++ V L ++ L T R + + ++I + Y +Y
Sbjct 3332 LADHFNYNVSVLQMDVQGLVNVLVCLFVVFLHTWRFSKERFTHWFTYVCSLIAVAYTYFY 3391
Query 3701 GNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVY 3760
+S+ + + S+ + + L+R IVF E +F ++ ++VY
Sbjct 3392 SGDF---LSLLVMFLCAISSDWYIGAIVFRLSRLIVFFSPE---SVFSVFGDVKLTLVVY 3445
Query 3761 CFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIK 3820
GY C Y+G+ NR+F+ T+GVYD+ VS EF+YM + GL P DA L+ K
Sbjct 3446 LICGYLVCTYWGILYWFNRFFKCTMGVYDFKVSAAEFKYMVANGLHAPHGPFDALWLSFK 3505
Query 3821 LLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKD 3880
LLGIGG CIK++TVQSK++D+KCT+VVLL L + + ++S WA CV LHN I L D
Sbjct 3506 LLGIGGDRCIKISTVQSKLTDLKCTNVVLLGCLSSMNIAANSSEWAYCVDLHNKINLCDD 3565
Query 3881 TTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEA 3940
+A +++LL+ LS ++ L + DN +TLQ++AS F S+PSY AY A++A
Sbjct 3566 PEKAQSMLLALLAFFLSKHSDFGLDGLIDSYFDNSSTLQSVASSFVSMPSYIAYENARQA 3625
Query 3941 YEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRA 4000
YE A+ANG S ++K+LK+++N+AKSEFD + ++Q+K+ +MA+QA TQMYK+ARS ++++
Sbjct 3626 YEDAIANGSSSQLIKQLKRAMNIAKSEFDHEISVQKKINRMAEQAATQMYKEARSVNRKS 3685
Query 4001 KVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNT 4060
KV SAM ++LF MLR+LD ++ ++N ARDG VPL++IP T+A+KL +V PD +Y
Sbjct 3686 KVISAMHSLLFGMLRRLDMSSVETVLNLARDGVVPLSVIPATSASKLTIVSPDLESYSKI 3745
Query 4061 CDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNE 4120
+ YA +W + V D D + V + EI +N L WPLI+ R VKLQNNE
Sbjct 3746 VCDGSVHYAGVVWTLNDVKDNDGRPVHVKEITKENVETLTWPLILNCER---VVKLQNNE 3802
Query 4121 LSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTG 4180
+ P L+Q A D NAL YN G F+ A +S+ DLK+ ++ G
Sbjct 3803 IMPGKLKQKPMKAEGDGGVLGDGNAL--YNTEGGKTFMYAYISNKADLKFVKWEYEGGCN 3860
Query 4181 TIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPAN 4240
TI EL+ PCRF+ +TP GP+VKYLYF+K LN L RG VLG + AT+RLQAG TE+ N
Sbjct 3861 TI--ELDSPCRFMVETPNGPQVKYLYFVKNLNTLRRGAVLGFIGATIRLQAGKQTELAVN 3918
Query 4241 STVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGG 4300
S +L+ CAF+VDPA Y + + G +P++NC+KML G GQAIT + +AN +Q+S+GG
Sbjct 3919 SGLLTACAFSVDPATTYLEAVKHGAKPVSNCIKMLSNGAGNGQAITTSVDANTNQDSYGG 3978
Query 4301 ASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
AS CLYCR H+ HP+ G+C KGK VQ+P C DP+ F L N VC VCG W G+GC+C
Sbjct 3979 ASICLYCRAHVPHPSMDGYCKFKGKCVQVPIGCL-DPIRFCLENNVCNVCGCWLGHGCAC 4037
Query 4361 DQLREPLMQSADASTFLN 4378
D+ +QS D S +LN
Sbjct 4038 DR---TTIQSVDIS-YLN 4051
Score = 235 bits (599), Expect = 8e-60, Method: Composition-based stats.
Identities = 77/357 (22%), Positives = 135/357 (38%), Gaps = 37/357 (10%)
Query 1519 VEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDG 1578
V+F ++ V+ ++ + + + T D N+ +V+ S + G+Q G DG
Sbjct 1562 VKFVVESNVMDVNDC------FKNDNVVLKITEDGINVKDVVVESSKSLGKQLGVVS-DG 1614
Query 1579 ADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFP-- 1636
D + EG + + DT+ S A E F + A K + +P
Sbjct 1615 VD--------SFEG---VLPINTDTVLSVAPEVDWVAFYGFEKAALFASLDVKPYGYPND 1663
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
VGG + DNNC++++ + LQ L+ F + L + + GD F + I +
Sbjct 1664 FVGGFRVLGTTDNNCWVNATCIILQYLKPTFKSKGLNVLWNKFVTGDVGPFVSFIYFITM 1723
Query 1697 KTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNL 1756
+ G+ GD E ++ L ++ L S V C +T+ V++ + ++ L
Sbjct 1724 SSKGQKGDAEEALSKLSEY--LISDSIVTLEQYSTCDICKSTVVEVKSAIVCASV----L 1777
Query 1757 KTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYT---GNYQCGHY 1813
K G + R + V+ + V+++ Q L YT G++ GHY
Sbjct 1778 KDGCDVGFCPHRHKLRSRVKFVNGRVVITNVGEPIISQPSKLLNGIAYTTFSGSFDNGHY 1837
Query 1814 THITAKETLYRIDGAHLTKMSEYKGPVTDVFYKE-------TSYTTTIKPVSYKLDG 1863
A DGA L VT + + + V KLD
Sbjct 1838 VVYDAANN-AVYDGARLFSSDLSTLAVTAIVVVGGCVTSNVPTIVSEKISVMDKLDT 1893
Score = 159 bits (403), Expect = 5e-37, Method: Composition-based stats.
Identities = 84/329 (26%), Positives = 130/329 (40%), Gaps = 38/329 (12%)
Query 979 EDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNA 1038
++ +T +++ V F Y NV DI + +VNA
Sbjct 1233 KNSSVNTVCFVDVDFHSVEIEAGEVKPFAVYK----NVKFYLGDISHLVNCVSFDFVVNA 1288
Query 1039 ANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGP 1098
AN +L HGGGVA A++ T G +Q S DYI NGPL VG +L +VVGP
Sbjct 1289 ANENLLHGGGVARAIDILTEGQLQSLSKDYISSNGPLKVGAGVMLECEKF--NVFNVVGP 1346
Query 1099 NLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQV---CVQTVRTQVYIAV 1155
E L++A I L PLLS GIFG + SL+ C QV++
Sbjct 1347 RTGKHEHSLLVEAYNSILFENGIPLMPLLSCGIFGVRIENSLKALFSCDINKPLQVFVYS 1406
Query 1156 NDKALYEQVVMDYLDNLK--PRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACID 1213
+++ EQ V+ +LD L P ++ +P E + + D
Sbjct 1407 SNE---EQAVLKFLDGLDLTPVIDDVDVVKPFRVEGNFSFF------------------D 1445
Query 1214 EVTTTLEETKFL--TNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDV----I 1267
L+ +L TN +L+ L +L+ + +L G++ +
Sbjct 1446 CGVNALDGDIYLLFTNSILMLDKQGQLLDTKLNGILQQAALDYLATVKTVPAGNLVKLFV 1505
Query 1268 TSGDITCVVIPSKKAGGTTEMLSRALKKV 1296
S I V+PS + L R ++K+
Sbjct 1506 ESCTIYMCVVPSINDLSFDKNLGRCVRKL 1534
Score = 79.8 bits (195), Expect = 9e-13, Method: Composition-based stats.
Identities = 42/200 (21%), Positives = 78/200 (39%), Gaps = 15/200 (8%)
Query 1617 ESFLGRYMSALNHTKKWKFPQVG--GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQE 1674
E L+ + + F G+ + +DNNC++S+ L+ LQ ++ ++ +Q
Sbjct 1026 EQPFEEVEHVLSIKQPFSFSFRDELGVRVLDQSDNNCWISTTLVQLQLTKLLDDSIEMQL 1085
Query 1675 AYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQ 1734
+ G + S+ G LGD + ++ LL+ S + C CG+
Sbjct 1086 ----FKVGKVDSIVQKCYELSHLISGSLGDSGKLLSELLKEKYTCSIT--FEMSCD-CGK 1138
Query 1735 KTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAP-PAEYKL 1793
K G ++ + G C+C + T LV + + V + P P +
Sbjct 1139 KFDDQVG---CLFWIMPYTKLFQKG--ECCICHKMQTYKLVSMKGTGVFVQDPAPIDIDA 1193
Query 1794 QQGTFLCANEYTGNYQCGHY 1813
+C++ Y G GHY
Sbjct 1194 FPVKPICSSVYLGVKGSGHY 1213
Score = 58.2 bits (139), Expect = 3e-06, Method: Composition-based stats.
Identities = 42/179 (23%), Positives = 56/179 (31%), Gaps = 30/179 (17%)
Query 179 GGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEI 238
G +VD CG DG P+ + E DY + +++
Sbjct 108 GAGSVVFVDKYMCGFDGKPVLP------------KNMWEFRDYFNNNTDSIVIGGVTYQL 155
Query 239 AWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMG 298
AW R D SYE Q I+S T K+ +P K G
Sbjct 156 AWDVIRKDLSYEQQNVLAIESIHYLGTT-----GHTLKSGCKLTNAKPPKYSSKVV-LSG 209
Query 299 RIRSVY-PVASPQECNNMHL----------STLMKCNHCDEVSWQTCDFLKATCEHCGT 346
+VY SP N M L + +KCN C SW + CGT
Sbjct 210 EWNAVYRAFGSPFITNGMSLLDIIVKPVFFNAFVKCN-CGSESWSVGAWDGYLSSCCGT 267
>sp|P0C6U6|R1A_CVHNL Replicase polyprotein 1a OS=Human coronavirus
NL63 OX=277944 GN=1a PE=1 SV=1
Length=4060
Score = 2613 bits (6772), Expect = 0.0, Method: Composition-based stats.
Identities = 761/2302 (33%), Positives = 1184/2302 (51%), Gaps = 119/2302 (5%)
Query 2096 LKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQ 2155
L T+A I + S + P + I+ + AQ+ F + +V +
Sbjct 1858 LSTLAVTAIVVVGGCVTSNV-----PTIVSEKISVMDKLDTGAQKFFQ-FGDFVMNNIVL 1911
Query 2156 LCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKF---SKLFTIAM-WLL 2211
T+ S S +R T+I K+ +K +AK G+ +S K+ S LF I W +
Sbjct 1912 FLTWLLSMFSLLR----TSIMKHDIKVIAKAPKRTGVILTRSFKYNIRSALFVIKQKWCV 1967
Query 2212 LLSICLGSLICVTAAFGVLLSNFGAPS---YCNGVRELYLNSSNVTTMDFCEGSFPCSIC 2268
++++ L+ V + +P C + Y S+ + +C S C +C
Sbjct 1968 IVTLFKFLLLLYAIYALVFMIVQFSPFNSLLCGDIVSGYEKSTFNKDI-YCGNSMVCKMC 2026
Query 2269 LSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYML-FTKFFYLLGLSAIMQVF 2327
L + + I D ++ L +L +L F + GL + F
Sbjct 2027 LFSYQEFNDLDHTSLVWKHIR----DPILISLQPFVILVILLIFGNMYLRFGLLYFVAQF 2082
Query 2328 FGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCM 2387
F S F+ WF+ P + ++ I HI+ GC ++ C+
Sbjct 2083 ISTFGS-FLGFHQKQWFL----HFVPFDVLCNEFLATFIVCKIVLFVRHIIVGCNNADCV 2137
Query 2388 MCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVA 2447
C K R RV TI+NGM +SFYV ANGG FC HN+ C+NCD+F G+TFI+ ++A
Sbjct 2138 ACSKSARLKRVPLQTIINGMHKSFYVNANGGTCFCNKHNFFCVNCDSFGPGNTFINGDIA 2197
Query 2448 RDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRAN 2507
R+L K + PT + I+D V NG LY + S + + L+
Sbjct 2198 RELGNVVKTAVQPTAPAYVIIDKVDFVNGFYRLYSGDTFWRYDFDITESKYSCKEVLKNC 2257
Query 2508 NTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKM 2567
N N IV++ S + + K+A VY+SQL+C+PI L++ L+S + S + + +
Sbjct 2258 NV----LENFIVYNN-SGSNITQIKNACVYFSQLLCEPIKLVNSELLSTL--SVDFNGVL 2310
Query 2568 FDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKD 2627
AYVD +F ++L A ++ A + G+ V D
Sbjct 2311 HKAYVDVLCNSF---FKELTANMSMAECKATLGLT--------------------VSDDD 2347
Query 2628 VIECLKLSHHSDLEVTGDSCNNFMLTYNKV-ENMTPRDLGACIDCNARHINAQVAKSHNV 2686
+ + +H D+ ++ S NNF ++Y K + ++ D+ C+ ++ +N V ++
Sbjct 2348 FVSAVANAHRYDVLLSDLSFNNFFISYAKPEDKLSVYDIACCMRAGSKVVNHNVLIKESI 2407
Query 2687 SLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTC 2746
++W VKD+ +LS++ +K + K + F LT + + V T I K G
Sbjct 2408 PIVWGVKDFNTLSQEGKKYLVKTTKAKGLTFLLTFNDNQAITQVPATSIVAKQGAGFKRT 2467
Query 2747 FKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFAN 2806
+ + L V + + T++ GY +K I++G + + C N
Sbjct 2468 YNFLWYVCLFVVALFIGVSFIDYTTTVTSFHGY-----DFKYIENGQLKVFEAPLHCVRN 2522
Query 2807 KHAGFDAWFSQRGGSYK-NDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRV 2865
F+ W + G N CP+V + R +VPG+P V + G L F +
Sbjct 2523 VFDNFNQWHEAKFGVVTTNSDKCPIVVGVSERI--NVVPGVPTNVY--LVGKTLVFTLQA 2578
Query 2866 FSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSEL 2925
+CY + C+ + CT + G V YCY+T+L+EGS YS L
Sbjct 2579 AFGNTGVCYDFDGVTTSD-----KCIFNSACTRLEGLGGDNV-YCYNTDLIEGSKPYSTL 2632
Query 2926 RPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLN 2984
+P+ Y + ++FP G +R + T YCR G C S G+C +W +N
Sbjct 2633 QPNAYYKYDAKNYVRFPEILARGFGLRTIRTLATRYCRVGECRDSHKGVCFGFD-KWYVN 2691
Query 2985 NEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKF 3044
+ R G CG ++L+ N+ + + +S ++ + A +T + KF
Sbjct 2692 DG--RVDDGYICGDGLIDLLVNVLSIFSSSFSVVAMSGHMLFNFLFAAFITFLCFLVTKF 2749
Query 3045 RRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDV--SFLAH 3102
+RVFG+ ++ V L++ I +V F +Y++ Y F FT V +++ H
Sbjct 2750 KRVFGDLSYGVFTVVCATLIN-NISYVVTQNLFFMLLYAILY----FVFTRTVRYAWIWH 2804
Query 3103 LQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFL 3161
+ + + ++P+W+ + F L+ F + + +F G F TFE AA TF+
Sbjct 2805 IAYIVAYFLLIPWWLLTWFSFAAFLELLPNVFKLKISTQ-LFEGDKFIGTFESAAAGTFV 2863
Query 3162 LNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNS 3221
L+ Y +L + + + Y A YNKYKY+SG+ YR A HLAKA+ D++
Sbjct 2864 LDMRSYERLINT--ISPEKLKNYAASYNKYKYYSGSASEADYRCACYAHLAKAMLDYAKD 2921
Query 3222 GADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRH 3281
D+LY PP S S LQSG +KMA PSG VE C+V+V G+T LNG+WL DTV CPRH
Sbjct 2922 HNDMLYSPPTISYNST-LQSGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRH 2980
Query 3282 VICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
VI + +L +Y+ H+F V V L V+G +M +LR+KV SN TPK+
Sbjct 2981 VIAPSTTVL-IDYDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHTPKH 3039
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYD-CVSFC 3400
F ++PG +F++LACY G SGV+ +R N TIKGSF+NG+CGS G+N+ D V FC
Sbjct 3040 VFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSPGYNVRNDGTVEFC 3099
Query 3401 YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFL 3460
Y+H +EL +G H G+D G YG F D+ + Q + ++ NV+A+LYAA++NG RW+L
Sbjct 3100 YLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLMLSDNVVAFLYAALLNGCRWWL 3159
Query 3461 NRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT 3520
++ FN AM Y ++ V+ L+A+TG++V + A+++ L G G+
Sbjct 3160 CSTRVNVDGFNEWAMANGYTSVSS--VECYSILAAKTGVSVEQLLASIQHL-HEGFGGKN 3216
Query 3521 ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLF 3580
ILG + L DEFT +VV+Q GV Q K++ G L + ++ ++
Sbjct 3217 ILGYSSLCDEFTLAEVVKQMYGVNLQSG--KVIFGLKTMFLFSVFFTMFWAELFI-YTNT 3273
Query 3581 FFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRI 3640
++ P ++ ++ + +KHK FL +FLLP++ A +N V ++++
Sbjct 3274 IWINPVILTPIFCLLLFLSLVLTMFLKHKFLFLQVFLLPTVIATALYNCVLD--YYIVKF 3331
Query 3641 MTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYY 3700
+ + S+ ++ V L ++ L T R + + ++I + Y +Y
Sbjct 3332 LADHFNYNVSVLQMDVQGLVNVLVCLFVVFLHTWRFSKERFTHWFTYVCSLIAVAYTYFY 3391
Query 3701 GNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVY 3760
+S+ + + S+ + + L+R IVF E +F ++ ++VY
Sbjct 3392 SGDF---LSLLVMFLCAISSDWYIGAIVFRLSRLIVFFSPE---SVFSVFGDVKLTLVVY 3445
Query 3761 CFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIK 3820
GY C Y+G+ NR+F+ T+GVYD+ VS EF+YM + GL P DA L+ K
Sbjct 3446 LICGYLVCTYWGILYWFNRFFKCTMGVYDFKVSAAEFKYMVANGLHAPHGPFDALWLSFK 3505
Query 3821 LLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKD 3880
LLGIGG CIK++TVQSK++D+KCT+VVLL L + + ++S WA CV LHN I L D
Sbjct 3506 LLGIGGDRCIKISTVQSKLTDLKCTNVVLLGCLSSMNIAANSSEWAYCVDLHNKINLCDD 3565
Query 3881 TTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEA 3940
+A +++LL+ LS ++ L + DN +TLQ++AS F S+PSY AY A++A
Sbjct 3566 PEKAQSMLLALLAFFLSKHSDFGLDGLIDSYFDNSSTLQSVASSFVSMPSYIAYENARQA 3625
Query 3941 YEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRA 4000
YE A+ANG S ++K+LK+++N+AKSEFD + ++Q+K+ +MA+QA TQMYK+ARS ++++
Sbjct 3626 YEDAIANGSSSQLIKQLKRAMNIAKSEFDHEISVQKKINRMAEQAATQMYKEARSVNRKS 3685
Query 4001 KVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNT 4060
KV SAM ++LF MLR+LD ++ ++N ARDG VPL++IP T+A+KL +V PD +Y
Sbjct 3686 KVISAMHSLLFGMLRRLDMSSVETVLNLARDGVVPLSVIPATSASKLTIVSPDLESYSKI 3745
Query 4061 CDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNE 4120
+ YA +W + V D D + V + EI +N L WPLI+ R VKLQNNE
Sbjct 3746 VCDGSVHYAGVVWTLNDVKDNDGRPVHVKEITKENVETLTWPLILNCER---VVKLQNNE 3802
Query 4121 LSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTG 4180
+ P L+Q A D NAL YN G F+ A +S+ DLK+ ++ G
Sbjct 3803 IMPGKLKQKPMKAEGDGGVLGDGNAL--YNTEGGKTFMYAYISNKADLKFVKWEYEGGCN 3860
Query 4181 TIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPAN 4240
TI EL+ PCRF+ +TP GP+VKYLYF+K LN L RG VLG + AT+RLQAG TE+ N
Sbjct 3861 TI--ELDSPCRFMVETPNGPQVKYLYFVKNLNTLRRGAVLGFIGATIRLQAGKQTELAVN 3918
Query 4241 STVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGG 4300
S +L+ CAF+VDPA Y + + G +P++NC+KML G GQAIT + +AN +Q+S+GG
Sbjct 3919 SGLLTACAFSVDPATTYLEAVKHGAKPVSNCIKMLSNGAGNGQAITTSVDANTNQDSYGG 3978
Query 4301 ASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSC 4360
AS CLYCR H+ HP+ G+C KGK VQ+P C DP+ F L N VC VCG W G+GC+C
Sbjct 3979 ASICLYCRAHVPHPSMDGYCKFKGKCVQVPIGCL-DPIRFCLENNVCNVCGCWLGHGCAC 4037
Query 4361 DQLREPLMQSADASTFLNGFAV 4382
D+ +QS D S +LN V
Sbjct 4038 DR---TTIQSVDIS-YLNEQGV 4055
Score = 234 bits (597), Expect = 1e-59, Method: Composition-based stats.
Identities = 74/339 (22%), Positives = 131/339 (39%), Gaps = 30/339 (9%)
Query 1519 VEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDG 1578
V+F ++ V+ ++ + + + T D N+ +V+ S + G+Q G DG
Sbjct 1562 VKFVVESNVMDVNDC------FKNDNVVLKITEDGINVKDVVVESSKSLGKQLGVVS-DG 1614
Query 1579 ADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFP-- 1636
D + EG + + DT+ S A E F + A K + +P
Sbjct 1615 VD--------SFEG---VLPINTDTVLSVAPEVDWVAFYGFEKAALFASLDVKPYGYPND 1663
Query 1637 QVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSN 1696
VGG + DNNC++++ + LQ L+ F + L + + GD F + I +
Sbjct 1664 FVGGFRVLGTTDNNCWVNATCIILQYLKPTFKSKGLNVLWNKFVTGDVGPFVSFIYFITM 1723
Query 1697 KTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNL 1756
+ G+ GD E ++ L ++ L S V C +T+ V++ + ++ L
Sbjct 1724 SSKGQKGDAEEALSKLSEY--LISDSIVTLEQYSTCDICKSTVVEVKSAIVCASV----L 1777
Query 1757 KTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYT---GNYQCGHY 1813
K G + R + V+ + V+++ Q L YT G++ GHY
Sbjct 1778 KDGCDVGFCPHRHKLRSRVKFVNGRVVITNVGEPIISQPSKLLNGIAYTTFSGSFDNGHY 1837
Query 1814 THITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTT 1852
A DGA L VT + T+
Sbjct 1838 VVYDAANN-AVYDGARLFSSDLSTLAVTAIVVVGGCVTS 1875
Score = 159 bits (402), Expect = 6e-37, Method: Composition-based stats.
Identities = 84/329 (26%), Positives = 130/329 (40%), Gaps = 38/329 (12%)
Query 979 EDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNA 1038
++ +T +++ V F Y NV DI + +VNA
Sbjct 1233 KNSSVNTVCFVDVDFHSVEIEAGEVKPFAVYK----NVKFYLGDISHLVNCVSFDFVVNA 1288
Query 1039 ANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGP 1098
AN +L HGGGVA A++ T G +Q S DYI NGPL VG +L +VVGP
Sbjct 1289 ANENLLHGGGVARAIDILTEGQLQSLSKDYISSNGPLKVGAGVMLECEKF--NVFNVVGP 1346
Query 1099 NLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQV---CVQTVRTQVYIAV 1155
E L++A I L PLLS GIFG + SL+ C QV++
Sbjct 1347 RTGKHEHSLLVEAYNSILFENGIPLMPLLSCGIFGVRIENSLKALFSCDINKPLQVFVYS 1406
Query 1156 NDKALYEQVVMDYLDNLK--PRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACID 1213
+++ EQ V+ +LD L P ++ +P E + + D
Sbjct 1407 SNE---EQAVLKFLDGLDLTPVIDDVDVVKPFRVEGNFSFF------------------D 1445
Query 1214 EVTTTLEETKFL--TNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDV----I 1267
L+ +L TN +L+ L +L+ + +L G++ +
Sbjct 1446 CGVNALDGDIYLLFTNSILMLDKQGQLLDTKLNGILQQAALDYLATVKTVPAGNLVKLFV 1505
Query 1268 TSGDITCVVIPSKKAGGTTEMLSRALKKV 1296
S I V+PS + L R ++K+
Sbjct 1506 ESCTIYMCVVPSINDLSFDKNLGRCVRKL 1534
Score = 79.4 bits (194), Expect = 1e-12, Method: Composition-based stats.
Identities = 42/200 (21%), Positives = 78/200 (39%), Gaps = 15/200 (8%)
Query 1617 ESFLGRYMSALNHTKKWKFPQVG--GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQE 1674
E L+ + + F G+ + +DNNC++S+ L+ LQ ++ ++ +Q
Sbjct 1026 EQPFEEVEHVLSIKQPFSFSFRDELGVRVLDQSDNNCWISTTLVQLQLTKLLDDSIEMQL 1085
Query 1675 AYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQ 1734
+ G + S+ G LGD + ++ LL+ S + C CG+
Sbjct 1086 ----FKVGKVDSIVQKCYELSHLISGSLGDSGKLLSELLKEKYTCSIT--FEMSCD-CGK 1138
Query 1735 KTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAP-PAEYKL 1793
K G ++ + G C+C + T LV + + V + P P +
Sbjct 1139 KFDDQVG---CLFWIMPYTKLFQKG--ECCICHKMQTYKLVSMKGTGVFVQDPAPIDIDA 1193
Query 1794 QQGTFLCANEYTGNYQCGHY 1813
+C++ Y G GHY
Sbjct 1194 FPVKPICSSVYLGVKGSGHY 1213
Score = 57.8 bits (138), Expect = 3e-06, Method: Composition-based stats.
Identities = 42/179 (23%), Positives = 56/179 (31%), Gaps = 30/179 (17%)
Query 179 GGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEI 238
G +VD CG DG P+ + E DY + +++
Sbjct 108 GAGSVVFVDKYMCGFDGKPVLP------------KNMWEFRDYFNNNTDSIVIGGVTYQL 155
Query 239 AWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMG 298
AW R D SYE Q I+S T K+ +P K G
Sbjct 156 AWDVIRKDLSYEQQNVLAIESIHYLGTT-----GHTLKSGCKLTNAKPPKYSSKVV-LSG 209
Query 299 RIRSVY-PVASPQECNNMHL----------STLMKCNHCDEVSWQTCDFLKATCEHCGT 346
+VY SP N M L + +KCN C SW + CGT
Sbjct 210 EWNAVYRAFGSPFITNGMSLLDIIVKPVFFNAFVKCN-CGSESWSVGAWDGYLSSCCGT 267
>sp|P0C6U2|R1A_CVH22 Replicase polyprotein 1a OS=Human coronavirus
229E OX=11137 GN=1a PE=1 SV=1
Length=4085
Score = 2599 bits (6737), Expect = 0.0, Method: Composition-based stats.
Identities = 759/2327 (33%), Positives = 1188/2327 (51%), Gaps = 128/2327 (6%)
Query 2077 VENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKR 2136
V+ T+ + S+ G + + H ++ ++ + YV P N
Sbjct 1859 VDKGHYTVYDTAKKSMYDGDRFV-KHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLDE 1917
Query 2137 LAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVK 2196
AQ+ F ++ ++ T+ S + + T + VK +AK G+ +
Sbjct 1918 KAQKFF-DFGDFLIHNFVIFFTWLLSMFTLCK----TAVTTGDVKIMAKAPQRTGVVLKR 1972
Query 2197 SPKFSKLFTIAM-----WLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
S K++ + A+ WLL L LI + +L FG ++C+ Y S
Sbjct 1973 SLKYNLKASAAVLKSKWWLLAKFTKLLLLIYTLYSVVLLCVRFGPFNFCSETVNGYAKS- 2031
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISS--------YKLDLTILGLAAE 2303
N D+C+GS C +CL G L + L+ + I+ + + + +L
Sbjct 2032 NFVKDDYCDGSLGCKMCLFGYQELSQFSHLDVVWKHITDPLFSNMQPFIVMVLLLIFGDN 2091
Query 2304 WVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIF 2363
++ ++L+ ++ + + + VF GY ++ WF+ P + +
Sbjct 2092 YLRCFLLY----FVAQMISTVGVFLGYKETN--------WFL----HFIPFDVICDELLV 2135
Query 2364 FASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK 2423
+ H++ GC + C+ C K R R TIVNG++RSFYV ANGG FCK
Sbjct 2136 TVIVIKVISFVRHVLFGCENPDCIACSKSARLKRFPVNTIVNGVQRSFYVNANGGSKFCK 2195
Query 2424 THNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFD 2483
H + C++CD++ GSTFI+ EV+R+L K + PT + ++D V +NG LY
Sbjct 2196 KHRFFCVDCDSYGYGSTFITPEVSRELGNITKTNVQPTGPAYVMIDKVEFENGFYRLYSC 2255
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+ + S + + + N + IVF+ + + K+ASVY+SQL+C
Sbjct 2256 ETFWRYNFDITESKYSCKEVFKNCNV----LDDFIVFNNNGT-NVTQVKNASVYFSQLLC 2310
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PI L+D L+S + S + + + AY+D +F L A ++ A + A G+++
Sbjct 2311 RPIKLVDSELLSTL--SVDFNGVLHKAYIDVLRNSFGKD---LNANMSLAECKRALGLSI 2365
Query 2604 DGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTP 2662
+ + +H D+ ++ S NNF+ +Y K E ++
Sbjct 2366 SD--------------------HEFTSAISNAHRCDVLLSDLSFNNFVSSYAKPEEKLSA 2405
Query 2663 RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCA 2722
DL C+ A+ +NA V ++W+ KD+ SLS + RK I +K + F LT
Sbjct 2406 YDLACCMRAGAKVVNANVLTKDQTPIVWHAKDFNSLSAEGRKYIVKTSKAKGLTFLLTIN 2465
Query 2723 TTRQVVNVITTKISLKGGKI--VSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYT 2780
+ V + T I K G + L L L+C++ +C+ MP I +
Sbjct 2466 ENQAVTQIPATSIVAKQGAGDAGHSLTWLWLLCGLVCLIQFYLCFF-MPYFMYDIVSSF- 2523
Query 2781 NEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAIITREI 2839
E +K I++G ++ + C N F+ W + G N +SCP+V + EI
Sbjct 2524 -EGYDFKYIENGQLKNFEAPLKCVRNVFENFEDWHYAKFGFTPLNKQSCPIVVGV--SEI 2580
Query 2840 GFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIF 2899
V G+P V + G L F + +CY + C+ + CT
Sbjct 2581 VNTVAGIPSNVY--LVGKTLIFTLQAAFGNAGVCYD-----IFGVTTPEKCIFTSACTRL 2633
Query 2900 KDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDA 2958
+ G V YCY+T L+EGS+ YS ++ + Y +G+ I+ P +G R V T
Sbjct 2634 EGLGGNNV-YCYNTALMEGSLPYSSIQANAYYKYDNGNFIKLPEVIAQGFGFRTVRTIAT 2692
Query 2959 EYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGAL 3018
+YCR G C S G+C +W +N+ R +G CG NL+ NI +
Sbjct 2693 KYCRVGECVESNAGVCFGFD-KWFVNDG--RVANGYVCGTGLWNLVFNILSMFSSSFSVA 2749
Query 3019 DVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFL 3078
+S ++ + + KFRR+FG+ + V + L++ +V
Sbjct 2750 AMSGQILLNCALGAFAIFCCFLVTKFRRMFGDLSVGVCTVVVAVLLNNV-SYIVTQNLVT 2808
Query 3079 PGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYL 3138
Y++ Y + T +++ + + P+W+ A Y + +
Sbjct 2809 MIAYAILYFFATRSL--RYAWIWCAAYLIAYISFAPWWLCAWYFLAMLTGLLPSLLKLKV 2866
Query 3139 RKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
+F G F TFE AA TF+++ Y KL + + + Y A YN+YKY+SG
Sbjct 2867 STN-LFEGDKFVGTFESAAAGTFVIDMRSYEKLANS--ISPEKLKSYAASYNRYKYYSGN 2923
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
+ YR A +LAKA+ DFS D+LY PP S S LQ+G RKMA PSG VE C+
Sbjct 2924 ANEADYRCACYAYLAKAMLDFSRDHNDILYTPPTVSYGST-LQAGLRKMAQPSGFVEKCV 2982
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V+V G T LNGLWL D VYCPRHVI + +Y+ H+F + +G L V
Sbjct 2983 VRVCYGNTVLNGLWLGDIVYCPRHVIASNTT-SAIDYDHEYSIMRLHNFSIISGTAFLGV 3041
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+G +M L++KV +N TP++ F ++ G+ F++LACY+G GV+ MR N TI+
Sbjct 3042 VGATMHGVTLKIKVSQTNMHTPRHSFRTLKSGEGFNILACYDGCAQGVFGVNMRTNWTIR 3101
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSF+NG+CGS G+N+ V F YMH +EL +G H G+ +G YG F D+ Q +
Sbjct 3102 GSFINGACGSPGYNLKNGEVEFVYMHQIELGSGSHVGSSFDGVMYGGFEDQPNLQVESAN 3161
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
+T+NV+A+LYAA++NG W+L + +N A + + + D L+A+T
Sbjct 3162 QMLTVNVVAFLYAAILNGCTWWLKGEKLFVEHYNEWAQANGFTAMNGE--DAFSILAAKT 3219
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKGT 3556
G+ V + A++ +L NG G+ ILG + L DEF+ +VV+Q GV Q GK + K
Sbjct 3220 GVCVERLLHAIQ-VLNNGFGGKQILGYSSLNDEFSINEVVKQMFGVNLQSGKTTSMFKSI 3278
Query 3557 HHWM-LLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCL 3615
+ + L + +T W V PF + ++A++ C +VKHK FL +
Sbjct 3279 SLFAGFFVMFWAELFVYTTTIW-----VNPGFLTPFMILLVALSLCLTFVVKHKVLFLQV 3333
Query 3616 FLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTAR 3675
FLLPS+ A N + V +++ + S+ ++ V L + +L T R
Sbjct 3334 FLLPSIIVAAIQNCAWD--YHVTKVLAEKFDYNVSVMQMDIQGFVNIFICLFVALLHTWR 3391
Query 3676 TVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA- 3734
+ L ++I ++Y Y +S+ +++ SN + I + R
Sbjct 3392 FAKERCTHWCTYLFSLIAVLYTALYSY---DYVSLLVMLLCAISNEWYIGAIIFRICRFG 3448
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
+ F+ VEY + ++ ++L Y LG+ C Y+GL +NR+ + TLGVYD+ VS
Sbjct 3449 VAFLPVEYVSY----FDGVKTVLLFYMLLGFVSCMYYGLLYWINRFCKCTLGVYDFCVSP 3504
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
EF+YM + GL P DA L+ KL+GIGG IKV+TVQSK++D+KCT+VVL+ +L
Sbjct 3505 AEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQSKLTDLKCTNVVLMGILS 3564
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
+ + S+SK WA CV++HN I L D A E +++LL+ LS + L + +N
Sbjct 3565 NMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFGLGDLVDSYFEN 3624
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAM 3974
+ LQ++AS F +PS+ AY TA++ YE AVANG S ++K+LKK++NVAK+EFDR++++
Sbjct 3625 DSILQSVASSFVGMPSFVAYETARQEYENAVANGSSPQIIKQLKKAMNVAKAEFDRESSV 3684
Query 3975 QRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCV 4034
Q+K+ +MA+QA MYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N AR+G V
Sbjct 3685 QKKINRMAEQAAAAMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNMARNGVV 3744
Query 4035 PLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD 4094
PL++IP T+AA+L+VVVPD+ ++ YA +W +Q+V D D K V L ++ +
Sbjct 3745 PLSVIPATSAARLVVVVPDHDSFVKMMVDGFVHYAGVVWTLQEVKDNDGKNVHLKDVTKE 3804
Query 4095 NSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKG 4154
N L WPLI+T R VKLQNNE+ P ++ + ++ NAL YNN G
Sbjct 3805 NQEILVWPLILTCER---VVKLQNNEIMPGKMKVKATKGEGDGGITSEGNAL--YNNEGG 3859
Query 4155 GRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNL 4214
F+ A ++ +K+ ++ G T+ ELEPPCRFV DTP GP++KYLYF+K LNNL
Sbjct 3860 RAFMYAYVTTKPGMKYVKWEHDSGVVTV--ELEPPCRFVIDTPTGPQIKYLYFVKNLNNL 3917
Query 4215 NRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM 4274
RG VLG + ATVRLQAG TE +NS +L+ C+FAVDPA AY D + G +P+ NCVKM
Sbjct 3918 RRGAVLGYIGATVRLQAGKQTEFVSNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKM 3977
Query 4275 LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCA 4334
L +G+GQAIT T ++N Q+++GGAS C+YCR H+ HP GFC KGK+VQ+P
Sbjct 3978 LTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHPTMDGFCQYKGKWVQVPIG-T 4036
Query 4335 NDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFA 4381
NDP+ F L NTVC VCG W +GC+CD+ +QS D S +LN
Sbjct 4037 NDPIRFCLENTVCKVCGCWLNHGCTCDR---TAIQSFDNS-YLNESG 4079
Score = 292 bits (748), Expect = 3e-77, Method: Composition-based stats.
Identities = 223/1435 (16%), Positives = 444/1435 (31%), Gaps = 205/1435 (14%)
Query 528 SVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSL-RLVDAMVY 586
+V PL F G F T+ + +L+ A + + D I+E L +D +
Sbjct 587 AVYKPLFAFNVNVMGTRPEKFPTTV-----TCENLESAVLFVNDKITEFQLDYSIDVIDN 641
Query 587 TSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT-----VEKLRPIFEWIEAKLSAGVEF 641
+ N + + V + + + + + +A + A
Sbjct 642 EIIVKPNISLCVPLYVRDYVDKWDDFCRQYSNESWFEDDYRAFISVLDITDAAVKAAESK 701
Query 642 ---------------LKDAWEILKFLITGVFDI------------VKGQIQVASDNIKDC 674
+ D +I +I V + +G + + K
Sbjct 702 AFVDTIVPPCPSILKVIDGGKIWNGVIKNVNSVRDWLKSLKLNLTQQGLLGTCAKRFKRW 761
Query 675 VKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLK 734
+ ++ N L+ + V I G ++ + +I + + + + + L P
Sbjct 762 LGILLEAYNAFLDTVVSTVKIGGLTFKTYAFDKPYIVIRDIVCKVENKTEAEWIELFPHN 821
Query 735 APKEV-----TFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLM 789
+ + + T EEV L + E F G ++ +
Sbjct 822 DRIKSFSTFESAYMPIADPTHFDIEEVELLDAE----------FVEPGCGGILAVIDEHV 871
Query 790 LLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFEL-D 847
+ KD Y S G F G V+F +D V +++ V++ FE D
Sbjct 872 FYK-KDGVYYP--SNGTNILPVAFTKAAGG---KVSFSDDVEVKDIEPVYRVKLCFEFED 925
Query 848 ERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFY 907
E++ V + + + + L V N+ T+Y
Sbjct 926 EKLVDVCEKAIG-----KKIKHEGDWDSFCKTIQSALS-VVSCYVNLP---------TYY 970
Query 908 LFDDAGEENFS-SRMY------------CSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
++D+ G + S M + P E+ D E I + +
Sbjct 971 IYDEEGGNDLSLPVMISEWPLSVQQAQQEATLPDIAEDVVDQVEEVNSIFDI--ETVDVK 1028
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTD 1014
D + F +++ + W++ Q ++ + + K+ +
Sbjct 1029 HDVSPFEMPFEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQFFKMGRVAKMIE 1088
Query 1015 NVA-----------IKCVDIVKEAQSANPMVIV-----NAANIHLKHGGGV--AGALNKA 1056
+ + + + + +V + + L+ G V KA
Sbjct 1089 RCYTAEQCIRGAMGDVGLCMYRLLKDLHTGFMVMDYKCSCTSGRLEESGAVLFCTPTKKA 1148
Query 1057 TNGAMQKESD-----DYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKA 1111
+ +L G + + VV P + +
Sbjct 1149 FPYGTCLNCNAPRMCTIRQLQGTI----IFVQQKPEPVNPVSFVVKPV-----CSSIFRG 1199
Query 1112 AYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDN 1171
A + Q + + L FG +Q + A Y V +
Sbjct 1200 AVSCGHYQTNIYSQNLCVDGFGVNKIQPWT------NDALNTICIKDADYNAKVEISVTP 1253
Query 1172 LKPRVEAPKQEEPPNTED--SKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKL 1229
+K V+ +EE E + +V DV + +
Sbjct 1254 IKNTVDTTPKEEFVVKEKLNAFLVHDNVAFYQGDVDTVVNGVDFDFIVNAANENLAHG-- 1311
Query 1230 LLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSG----DITCVVIPSKKAGGT 1285
+ L ++ L+ + VG + I VV P +K
Sbjct 1312 ---GGLAKALDVYTKGKLQRLSKEHIGLAGKVKVGTGVMVECDSLRIFNVVGP-RKGKHE 1367
Query 1286 TEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILG 1345
++L +A + +E T G + +T+L+ + + +
Sbjct 1368 RDLLIKAYNTIN-NEQGTPLTPILSCGIFGIKLETSLEVLLDVCNTKEVKVFVYTDTEVC 1426
Query 1346 TVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKE 1405
V + ++ + + + ++ I+ + + VD +F
Sbjct 1427 KVKDFVSGLVNVQKVEQPKI-----EPKPVSVIK-----VAPKPYRVDGKFSYF------ 1470
Query 1406 PVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGY 1465
++ + +P+V + L++ + + V+S + D V
Sbjct 1471 -TEDLLCVADD--KPIVL----FTDSMLTLDDRGLALDN-ALSGVLSAAIKDCVDINKAI 1522
Query 1466 LTSS-SKTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLD 1524
+ + K V + + S +D K + P ++ L
Sbjct 1523 PSGNLIKFDIGSVVVYMCVVPSEKDKHLDNNVQRCT---RKLNRLMCDIVCTIPADYILP 1579
Query 1525 GEVLSLDKLKSL---LSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADV 1581
+ SL S L E K I + T D N+H V ++ QQ G D+
Sbjct 1580 LVLSSLTCNVSFVGELKAAEAKVITIKVTEDGVNVHDVTVTTDKSFEQQVGVIADKDKDL 1639
Query 1582 TKIKPHVNHEGKTFFVLPSDDTLRSEAFE---YYHTLDESFLGRYMSALNHTKKWKFPQV 1638
+ P + + D + F+ + T+D S ++ V
Sbjct 1640 SGAVPSDLNTSELLTKAIDVDWVEFYGFKDAVTFATVDHSAFA-----------YESAVV 1688
Query 1639 GGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKT 1698
G+ +K +DNNC++++V +ALQ + F + L A+ + GD F A + +
Sbjct 1689 NGIRVLKTSDNNCWVNAVCIALQYSKPHFISQGLDAAWNKFVLGDVEIFVAFVYYVARLM 1748
Query 1699 VGELGDVRETMTHLLQH-ANLESAKRVLNVVCKHCGQK-TTTLTGVEAVMYMGTLSYDNL 1756
G+ GD +T+T L ++ AN + C C K ++ + + + ++ D +
Sbjct 1749 KGDKGDAEDTLTKLSKYLANEAQVQLEHYSSCVECDAKFKNSVASINSAIVCASVKRDGV 1808
Query 1757 KTGVSIPCVCGRDATQYLVQQESSFVMMSA----PPAEYKLQQGTFLCANEYTGNYQCGH 1812
+ G CV G + +++S P A+ +L G A ++G GH
Sbjct 1809 QVGY---CVHGIKYYSRVRSVRGRAIIVSVEQLEPCAQSRLLSGVAYTA--FSGPVDKGH 1863
Query 1813 YT-HITAKETLYRIDGAHLTKMSEYKGPVTDVF----YKETSYTTTIKPVSYKLD 1862
YT + TAK+++Y DG K VT V Y T KPV +LD
Sbjct 1864 YTVYDTAKKSMY--DGDRFVKHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLD 1916
Score = 99.0 bits (245), Expect = 1e-18, Method: Composition-based stats.
Identities = 51/269 (19%), Positives = 95/269 (35%), Gaps = 24/269 (9%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
F ++ GL +K DNNC+++SV+L +Q + A+Q + G A
Sbjct 1037 PFEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQF----FKMGRVAKMIERCYT 1092
Query 1694 YSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSY 1753
G +GDV M LL+ +L + V++ C + V
Sbjct 1093 AEQCIRGAMGDVGLCMYRLLK--DLHTGFMVMDYKCSCTSGRLEESGAVLFCTPTKK--- 1147
Query 1754 DNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTF--LCANEYTGNYQCG 1811
C + Q + + + + P +C++ + G CG
Sbjct 1148 ---AFPYGTCLNCNAPRMCTIRQLQGTIIFVQQKPEPVNPVSFVVKPVCSSIFRGAVSCG 1204
Query 1812 HYTHITAKETLYRIDGAHLTKM------SEYKGPVTDVFYKETSYTTTIKPVSYKLDGVT 1865
HY + L +DG + K+ + + D Y ++ P+ +D
Sbjct 1205 HYQTNIYSQNL-CVDGFGVNKIQPWTNDALNTICIKDADY-NAKVEISVTPIKNTVDTTP 1262
Query 1866 YTE--IEPKLDGYYKKDNAYYTEQPIDLV 1892
E ++ KL+ + DN + + +D V
Sbjct 1263 KEEFVVKEKLNAFLVHDNVAFYQGDVDTV 1291
Score = 47.0 bits (110), Expect = 0.005, Method: Composition-based stats.
Identities = 37/179 (21%), Positives = 60/179 (34%), Gaps = 31/179 (17%)
Query 176 ELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHE 235
+ GG VT Y D CG DG P+ L + +D+ + H
Sbjct 107 KRGGGNVT-YTDQYLCGADGKPV------------MSEDLWQFVDHFGENEEII-INGHT 152
Query 236 HEIAWFTERSDKSYEHQTPFEIKSA--KKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKT 293
+ AW T+R Y+ Q I+ D V + +VK K
Sbjct 153 YVCAWLTKRKPLDYKRQNNLAIEEIEYVHGDALHTLRNGSVLEMAKEVKT----SSKVVL 208
Query 294 EGFMGRIRSVYPVASPQECNNM--------HLSTLMKCNHCDEVSWQTCD--FLKATCE 342
+ ++ V+ +N+ +S L++C C SW D K++C
Sbjct 209 SDALDKLYKVFGSPVMTNGSNILEAFTKPVFISALVQCT-CGTKSWSVGDWTGFKSSCC 266
>sp|P0C6X1|R1AB_CVH22 Replicase polyprotein 1ab OS=Human coronavirus
229E OX=11137 GN=rep PE=1 SV=1
Length=6758
Score = 2598 bits (6733), Expect = 0.0, Method: Composition-based stats.
Identities = 757/2324 (33%), Positives = 1188/2324 (51%), Gaps = 128/2324 (6%)
Query 2077 VENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKR 2136
V+ T+ + S+ G + + H ++ ++ + YV P N
Sbjct 1859 VDKGHYTVYDTAKKSMYDGDRFV-KHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLDE 1917
Query 2137 LAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVK 2196
AQ+ F ++ ++ T+ S + + T + VK +AK G+ +
Sbjct 1918 KAQKFF-DFGDFLIHNFVIFFTWLLSMFTLCK----TAVTTGDVKIMAKAPQRTGVVLKR 1972
Query 2197 SPKFSKLFTIAM-----WLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
S K++ + A+ WLL L LI + +L FG ++C+ Y S
Sbjct 1973 SLKYNLKASAAVLKSKWWLLAKFTKLLLLIYTLYSVVLLCVRFGPFNFCSETVNGYAKS- 2031
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISS--------YKLDLTILGLAAE 2303
N D+C+GS C +CL G L + L+ + I+ + + + +L
Sbjct 2032 NFVKDDYCDGSLGCKMCLFGYQELSQFSHLDVVWKHITDPLFSNMQPFIVMVLLLIFGDN 2091
Query 2304 WVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIF 2363
++ ++L+ ++ + + + VF GY ++ WF+ P + +
Sbjct 2092 YLRCFLLY----FVAQMISTVGVFLGYKETN--------WFL----HFIPFDVICDELLV 2135
Query 2364 FASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCK 2423
+ H++ GC + C+ C K R R TIVNG++RSFYV ANGG FCK
Sbjct 2136 TVIVIKVISFVRHVLFGCENPDCIACSKSARLKRFPVNTIVNGVQRSFYVNANGGSKFCK 2195
Query 2424 THNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFD 2483
H + C++CD++ GSTFI+ EV+R+L K + PT + ++D V +NG LY
Sbjct 2196 KHRFFCVDCDSYGYGSTFITPEVSRELGNITKTNVQPTGPAYVMIDKVEFENGFYRLYSC 2255
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+ + S + + + N + IVF+ + + K+ASVY+SQL+C
Sbjct 2256 ETFWRYNFDITESKYSCKEVFKNCNV----LDDFIVFNNNGT-NVTQVKNASVYFSQLLC 2310
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PI L+D L+S + S + + + AY+D +F L A ++ A + A G+++
Sbjct 2311 RPIKLVDSELLSTL--SVDFNGVLHKAYIDVLRNSFGKD---LNANMSLAECKRALGLSI 2365
Query 2604 DGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE-NMTP 2662
+ + +H D+ ++ S NNF+ +Y K E ++
Sbjct 2366 SD--------------------HEFTSAISNAHRCDVLLSDLSFNNFVSSYAKPEEKLSA 2405
Query 2663 RDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCA 2722
DL C+ A+ +NA V ++W+ KD+ SLS + RK I +K + F LT
Sbjct 2406 YDLACCMRAGAKVVNANVLTKDQTPIVWHAKDFNSLSAEGRKYIVKTSKAKGLTFLLTIN 2465
Query 2723 TTRQVVNVITTKISLKGGKI--VSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYT 2780
+ V + T I K G + L L L+C++ +C+ MP I +
Sbjct 2466 ENQAVTQIPATSIVAKQGAGDAGHSLTWLWLLCGLVCLIQFYLCFF-MPYFMYDIVSSF- 2523
Query 2781 NEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAIITREI 2839
E +K I++G ++ + C N F+ W + G N +SCP+V + EI
Sbjct 2524 -EGYDFKYIENGQLKNFEAPLKCVRNVFENFEDWHYAKFGFTPLNKQSCPIVVGV--SEI 2580
Query 2840 GFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIF 2899
V G+P V + G L F + +CY + C+ + CT
Sbjct 2581 VNTVAGIPSNVY--LVGKTLIFTLQAAFGNAGVCYD-----IFGVTTPEKCIFTSACTRL 2633
Query 2900 KDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDA 2958
+ G V YCY+T L+EGS+ YS ++ + Y +G+ I+ P +G R V T
Sbjct 2634 EGLGGNNV-YCYNTALMEGSLPYSSIQANAYYKYDNGNFIKLPEVIAQGFGFRTVRTIAT 2692
Query 2959 EYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGAL 3018
+YCR G C S G+C +W +N+ R +G CG NL+ NI +
Sbjct 2693 KYCRVGECVESNAGVCFGFD-KWFVNDG--RVANGYVCGTGLWNLVFNILSMFSSSFSVA 2749
Query 3019 DVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFL 3078
+S ++ + + KFRR+FG+ + ++ ++ + +V
Sbjct 2750 AMSGQILLNCALGAFAIFCCFLVTKFRRMFGDLSVG-VCTVVVAVLLNNVSYIVTQNLVT 2808
Query 3079 PGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYL 3138
Y++ Y + T +++ + + P+W+ A Y + +
Sbjct 2809 MIAYAILYFFATRSL--RYAWIWCAAYLIAYISFAPWWLCAWYFLAMLTGLLPSLLKLKV 2866
Query 3139 RKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGA 3197
+F G F TFE AA TF+++ Y KL + + + Y A YN+YKY+SG
Sbjct 2867 STN-LFEGDKFVGTFESAAAGTFVIDMRSYEKLANS--ISPEKLKSYAASYNRYKYYSGN 2923
Query 3198 LDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCM 3257
+ YR A +LAKA+ DFS D+LY PP S S LQ+G RKMA PSG VE C+
Sbjct 2924 ANEADYRCACYAYLAKAMLDFSRDHNDILYTPPTVSYGST-LQAGLRKMAQPSGFVEKCV 2982
Query 3258 VQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRV 3317
V+V G T LNGLWL D VYCPRHVI + +Y+ H+F + +G L V
Sbjct 2983 VRVCYGNTVLNGLWLGDIVYCPRHVIASNTT-SAIDYDHEYSIMRLHNFSIISGTAFLGV 3041
Query 3318 IGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIK 3377
+G +M L++KV +N TP++ F ++ G+ F++LACY+G GV+ MR N TI+
Sbjct 3042 VGATMHGVTLKIKVSQTNMHTPRHSFRTLKSGEGFNILACYDGCAQGVFGVNMRTNWTIR 3101
Query 3378 GSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTD 3437
GSF+NG+CGS G+N+ V F YMH +EL +G H G+ +G YG F D+ Q +
Sbjct 3102 GSFINGACGSPGYNLKNGEVEFVYMHQIELGSGSHVGSSFDGVMYGGFEDQPNLQVESAN 3161
Query 3438 TTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQT 3497
+T+NV+A+LYAA++NG W+L + +N A + + + D L+A+T
Sbjct 3162 QMLTVNVVAFLYAAILNGCTWWLKGEKLFVEHYNEWAQANGFTAMNGE--DAFSILAAKT 3219
Query 3498 GIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKIVKGT 3556
G+ V + A++ +L NG G+ ILG + L DEF+ +VV+Q GV Q GK + K
Sbjct 3220 GVCVERLLHAIQ-VLNNGFGGKQILGYSSLNDEFSINEVVKQMFGVNLQSGKTTSMFKSI 3278
Query 3557 HHWM-LLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCL 3615
+ + L + +T W V PF + ++A++ C +VKHK FL +
Sbjct 3279 SLFAGFFVMFWAELFVYTTTIW-----VNPGFLTPFMILLVALSLCLTFVVKHKVLFLQV 3333
Query 3616 FLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTAR 3675
FLLPS+ A N + V +++ + S+ ++ V L + +L T R
Sbjct 3334 FLLPSIIVAAIQNCAWD--YHVTKVLAEKFDYNVSVMQMDIQGFVNIFICLFVALLHTWR 3391
Query 3676 TVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA- 3734
+ L ++I ++Y Y +S+ +++ SN + I + R
Sbjct 3392 FAKERCTHWCTYLFSLIAVLYTALYSY---DYVSLLVMLLCAISNEWYIGAIIFRICRFG 3448
Query 3735 IVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVST 3794
+ F+ VEY + ++ ++L Y LG+ C Y+GL +NR+ + TLGVYD+ VS
Sbjct 3449 VAFLPVEYVSY----FDGVKTVLLFYMLLGFVSCMYYGLLYWINRFCKCTLGVYDFCVSP 3504
Query 3795 QEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQ 3854
EF+YM + GL P DA L+ KL+GIGG IKV+TVQSK++D+KCT+VVL+ +L
Sbjct 3505 AEFKYMVANGLNAPNGPFDALFLSFKLMGIGGPRTIKVSTVQSKLTDLKCTNVVLMGILS 3564
Query 3855 QLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDN 3914
+ + S+SK WA CV++HN I L D A E +++LL+ LS + L + +N
Sbjct 3565 NMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFGLGDLVDSYFEN 3624
Query 3915 RATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAM 3974
+ LQ++AS F +PS+ AY TA++ YE AVANG S ++K+LKK++NVAK+EFDR++++
Sbjct 3625 DSILQSVASSFVGMPSFVAYETARQEYENAVANGSSPQIIKQLKKAMNVAKAEFDRESSV 3684
Query 3975 QRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCV 4034
Q+K+ +MA+QA MYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N AR+G V
Sbjct 3685 QKKINRMAEQAAAAMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNMARNGVV 3744
Query 4035 PLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMD 4094
PL++IP T+AA+L+VVVPD+ ++ YA +W +Q+V D D K V L ++ +
Sbjct 3745 PLSVIPATSAARLVVVVPDHDSFVKMMVDGFVHYAGVVWTLQEVKDNDGKNVHLKDVTKE 3804
Query 4095 NSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKG 4154
N L WPLI+T R VKLQNNE+ P ++ + ++ NAL YNN G
Sbjct 3805 NQEILVWPLILTCER---VVKLQNNEIMPGKMKVKATKGEGDGGITSEGNAL--YNNEGG 3859
Query 4155 GRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNL 4214
F+ A ++ +K+ ++ G T+ ELEPPCRFV DTP GP++KYLYF+K LNNL
Sbjct 3860 RAFMYAYVTTKPGMKYVKWEHDSGVVTV--ELEPPCRFVIDTPTGPQIKYLYFVKNLNNL 3917
Query 4215 NRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKM 4274
RG VLG + ATVRLQAG TE +NS +L+ C+FAVDPA AY D + G +P+ NCVKM
Sbjct 3918 RRGAVLGYIGATVRLQAGKQTEFVSNSHLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKM 3977
Query 4275 LCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCA 4334
L +G+GQAIT T ++N Q+++GGAS C+YCR H+ HP GFC KGK+VQ+P
Sbjct 3978 LTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHPTMDGFCQYKGKWVQVPIG-T 4036
Query 4335 NDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
NDP+ F L NTVC VCG W +GC+CD+ +QS D S +LN
Sbjct 4037 NDPIRFCLENTVCKVCGCWLNHGCTCDR---TAIQSFDNS-YLN 4076
Score = 292 bits (748), Expect = 4e-77, Method: Composition-based stats.
Identities = 223/1435 (16%), Positives = 444/1435 (31%), Gaps = 205/1435 (14%)
Query 528 SVLTPLCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSL-RLVDAMVY 586
+V PL F G F T+ + +L+ A + + D I+E L +D +
Sbjct 587 AVYKPLFAFNVNVMGTRPEKFPTTV-----TCENLESAVLFVNDKITEFQLDYSIDVIDN 641
Query 587 TSDLLTNSVIIMAYVTGGLVQQTSQWLSNLLGTT-----VEKLRPIFEWIEAKLSAGVEF 641
+ N + + V + + + + + +A + A
Sbjct 642 EIIVKPNISLCVPLYVRDYVDKWDDFCRQYSNESWFEDDYRAFISVLDITDAAVKAAESK 701
Query 642 ---------------LKDAWEILKFLITGVFDI------------VKGQIQVASDNIKDC 674
+ D +I +I V + +G + + K
Sbjct 702 AFVDTIVPPCPSILKVIDGGKIWNGVIKNVNSVRDWLKSLKLNLTQQGLLGTCAKRFKRW 761
Query 675 VKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLK 734
+ ++ N L+ + V I G ++ + +I + + + + + L P
Sbjct 762 LGILLEAYNAFLDTVVSTVKIGGLTFKTYAFDKPYIVIRDIVCKVENKTEAEWIELFPHN 821
Query 735 APKEV-----TFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLM 789
+ + + T EEV L + E F G ++ +
Sbjct 822 DRIKSFSTFESAYMPIADPTHFDIEEVELLDAE----------FVEPGCGGILAVIDEHV 871
Query 790 LLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFEL-D 847
+ KD Y S G F G V+F +D V +++ V++ FE D
Sbjct 872 FYK-KDGVYYP--SNGTNILPVAFTKAAGG---KVSFSDDVEVKDIEPVYRVKLCFEFED 925
Query 848 ERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFY 907
E++ V + + + + L V N+ T+Y
Sbjct 926 EKLVDVCEKAIG-----KKIKHEGDWDSFCKTIQSALS-VVSCYVNLP---------TYY 970
Query 908 LFDDAGEENFS-SRMY------------CSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
++D+ G + S M + P E+ D E I + +
Sbjct 971 IYDEEGGNDLSLPVMISEWPLSVQQAQQEATLPDIAEDVVDQVEEVNSIFDI--ETVDVK 1028
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTD 1014
D + F +++ + W++ Q ++ + + K+ +
Sbjct 1029 HDVSPFEMPFEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQFFKMGRVAKMIE 1088
Query 1015 NVA-----------IKCVDIVKEAQSANPMVIV-----NAANIHLKHGGGV--AGALNKA 1056
+ + + + + +V + + L+ G V KA
Sbjct 1089 RCYTAEQCIRGAMGDVGLCMYRLLKDLHTGFMVMDYKCSCTSGRLEESGAVLFCTPTKKA 1148
Query 1057 TNGAMQKESD-----DYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKA 1111
+ +L G + + VV P + +
Sbjct 1149 FPYGTCLNCNAPRMCTIRQLQGTI----IFVQQKPEPVNPVSFVVKPV-----CSSIFRG 1199
Query 1112 AYENFNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDN 1171
A + Q + + L FG +Q + A Y V +
Sbjct 1200 AVSCGHYQTNIYSQNLCVDGFGVNKIQPWT------NDALNTICIKDADYNAKVEISVTP 1253
Query 1172 LKPRVEAPKQEEPPNTED--SKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKL 1229
+K V+ +EE E + +V DV + +
Sbjct 1254 IKNTVDTTPKEEFVVKEKLNAFLVHDNVAFYQGDVDTVVNGVDFDFIVNAANENLAHG-- 1311
Query 1230 LLFADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSG----DITCVVIPSKKAGGT 1285
+ L ++ L+ + VG + I VV P +K
Sbjct 1312 ---GGLAKALDVYTKGKLQRLSKEHIGLAGKVKVGTGVMVECDSLRIFNVVGP-RKGKHE 1367
Query 1286 TEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILG 1345
++L +A + +E T G + +T+L+ + + +
Sbjct 1368 RDLLIKAYNTIN-NEQGTPLTPILSCGIFGIKLETSLEVLLDVCNTKEVKVFVYTDTEVC 1426
Query 1346 TVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKE 1405
V + ++ + + + ++ I+ + + VD +F
Sbjct 1427 KVKDFVSGLVNVQKVEQPKI-----EPKPVSVIK-----VAPKPYRVDGKFSYF------ 1470
Query 1406 PVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGY 1465
++ + +P+V + L++ + + V+S + D V
Sbjct 1471 -TEDLLCVADD--KPIVL----FTDSMLTLDDRGLALDN-ALSGVLSAAIKDCVDINKAI 1522
Query 1466 LTSS-SKTSEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLD 1524
+ + K V + + S +D K + P ++ L
Sbjct 1523 PSGNLIKFDIGSVVVYMCVVPSEKDKHLDNNVQRCT---RKLNRLMCDIVCTIPADYILP 1579
Query 1525 GEVLSLDKLKSL---LSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADV 1581
+ SL S L E K I + T D N+H V ++ QQ G D+
Sbjct 1580 LVLSSLTCNVSFVGELKAAEAKVITIKVTEDGVNVHDVTVTTDKSFEQQVGVIADKDKDL 1639
Query 1582 TKIKPHVNHEGKTFFVLPSDDTLRSEAFE---YYHTLDESFLGRYMSALNHTKKWKFPQV 1638
+ P + + D + F+ + T+D S ++ V
Sbjct 1640 SGAVPSDLNTSELLTKAIDVDWVEFYGFKDAVTFATVDHSAFA-----------YESAVV 1688
Query 1639 GGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKT 1698
G+ +K +DNNC++++V +ALQ + F + L A+ + GD F A + +
Sbjct 1689 NGIRVLKTSDNNCWVNAVCIALQYSKPHFISQGLDAAWNKFVLGDVEIFVAFVYYVARLM 1748
Query 1699 VGELGDVRETMTHLLQH-ANLESAKRVLNVVCKHCGQK-TTTLTGVEAVMYMGTLSYDNL 1756
G+ GD +T+T L ++ AN + C C K ++ + + + ++ D +
Sbjct 1749 KGDKGDAEDTLTKLSKYLANEAQVQLEHYSSCVECDAKFKNSVASINSAIVCASVKRDGV 1808
Query 1757 KTGVSIPCVCGRDATQYLVQQESSFVMMSA----PPAEYKLQQGTFLCANEYTGNYQCGH 1812
+ G CV G + +++S P A+ +L G A ++G GH
Sbjct 1809 QVGY---CVHGIKYYSRVRSVRGRAIIVSVEQLEPCAQSRLLSGVAYTA--FSGPVDKGH 1863
Query 1813 YT-HITAKETLYRIDGAHLTKMSEYKGPVTDVF----YKETSYTTTIKPVSYKLD 1862
YT + TAK+++Y DG K VT V Y T KPV +LD
Sbjct 1864 YTVYDTAKKSMY--DGDRFVKHDLSLLSVTSVVMVGGYVAPVNTVKPKPVINQLD 1916
Score = 99.0 bits (245), Expect = 1e-18, Method: Composition-based stats.
Identities = 51/269 (19%), Positives = 95/269 (35%), Gaps = 24/269 (9%)
Query 1634 KFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA 1693
F ++ GL +K DNNC+++SV+L +Q + A+Q + G A
Sbjct 1037 PFEELNGLKILKQLDNNCWVNSVMLQIQLTGILDGDYAMQF----FKMGRVAKMIERCYT 1092
Query 1694 YSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSY 1753
G +GDV M LL+ +L + V++ C + V
Sbjct 1093 AEQCIRGAMGDVGLCMYRLLK--DLHTGFMVMDYKCSCTSGRLEESGAVLFCTPTKK--- 1147
Query 1754 DNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTF--LCANEYTGNYQCG 1811
C + Q + + + + P +C++ + G CG
Sbjct 1148 ---AFPYGTCLNCNAPRMCTIRQLQGTIIFVQQKPEPVNPVSFVVKPVCSSIFRGAVSCG 1204
Query 1812 HYTHITAKETLYRIDGAHLTKM------SEYKGPVTDVFYKETSYTTTIKPVSYKLDGVT 1865
HY + L +DG + K+ + + D Y ++ P+ +D
Sbjct 1205 HYQTNIYSQNL-CVDGFGVNKIQPWTNDALNTICIKDADY-NAKVEISVTPIKNTVDTTP 1262
Query 1866 YTE--IEPKLDGYYKKDNAYYTEQPIDLV 1892
E ++ KL+ + DN + + +D V
Sbjct 1263 KEEFVVKEKLNAFLVHDNVAFYQGDVDTV 1291
Score = 47.0 bits (110), Expect = 0.005, Method: Composition-based stats.
Identities = 37/179 (21%), Positives = 60/179 (34%), Gaps = 31/179 (17%)
Query 176 ELNGGAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHE 235
+ GG VT Y D CG DG P+ L + +D+ + H
Sbjct 107 KRGGGNVT-YTDQYLCGADGKPV------------MSEDLWQFVDHFGENEEII-INGHT 152
Query 236 HEIAWFTERSDKSYEHQTPFEIKSA--KKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKT 293
+ AW T+R Y+ Q I+ D V + +VK K
Sbjct 153 YVCAWLTKRKPLDYKRQNNLAIEEIEYVHGDALHTLRNGSVLEMAKEVKT----SSKVVL 208
Query 294 EGFMGRIRSVYPVASPQECNNM--------HLSTLMKCNHCDEVSWQTCD--FLKATCE 342
+ ++ V+ +N+ +S L++C C SW D K++C
Sbjct 209 SDALDKLYKVFGSPVMTNGSNILEAFTKPVFISALVQCT-CGTKSWSVGDWTGFKSSCC 266
>sp|P0C6F6|R1A_BC512 Replicase polyprotein 1a OS=Bat coronavirus
512/2005 OX=693999 GN=1a PE=3 SV=1
Length=4128
Score = 2587 bits (6706), Expect = 0.0, Method: Composition-based stats.
Identities = 784/2392 (33%), Positives = 1229/2392 (51%), Gaps = 132/2392 (6%)
Query 2012 GMDNLACESQQPTSEEVVE-NPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
G+D+ C P + VV N T+ + V +L
Sbjct 1841 GLDDGNCVHGLPLVDRVVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGV 1900
Query 2071 DLMAAYVENTSIT----IKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQA 2126
+ + + + KP +L+++ + + + P ++ FL
Sbjct 1901 GHYTVFDKEAKLMFDGDVLKPCDLNVSPVTSVVVCNNKKIVVQDPVKRVELDASKFLDTM 1960
Query 2127 AITTSNCAKRL--AQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPT---TIAKNSVK 2181
+ + R + Y+F+LL K + ++ A +P I K SVK
Sbjct 1961 NVASEKFFTFGDFVSRNIIVLIVYLFSLLAICFRALKKRDMKVMAGVPERTGIILKRSVK 2020
Query 2182 SVAKLCLDAGINYVKSPKFSKL-FTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYC 2240
NY F +L F L S+ L +L + F + + G P C
Sbjct 2021 ----------YNYKALKFFFRLKFQYIKVFLKFSLVLYTLYALMFMF-IRFTPVGTP-IC 2068
Query 2241 NGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGL 2300
+ Y NS+ D+C C ICL G + L + I + L IL L
Sbjct 2069 KRYTDGYANST-FDKNDYCGN-VLCKICLYGYEELSDFTHTRVIWQHLKD-PLIGNILPL 2125
Query 2301 AAEWVLAYMLFTKFFYLLGLSAIMQVFFGY--FASHFISNSWLMWFIISIVQMAPVSAMV 2358
+++ ++F FF +G++ + + A + N WL+ + P ++M
Sbjct 2126 F--YLVFLIIFGGFFVRIGITYFIMQYINAAGVALGYQDNVWLL-------HLLPFNSMG 2176
Query 2359 RMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ + I H++ GC +C+ C K + TRV TI+ G+ +SFYV ANGG
Sbjct 2177 NIIVVAFIVTRILLFLKHVLFGCDKPSCIACSKSAKLTRVPLQTILQGVTKSFYVNANGG 2236
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
+ FCK HN+ C++CD++ G TFI+D +A +LS K + PT ++ I+D V NG
Sbjct 2237 KKFCKKHNFFCVDCDSYGYGCTFINDVIAPELSNVTKLNVIPTGPATIIIDKVEFSNGFY 2296
Query 2479 HLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYY 2538
+LY K + + D L+ N + + +VF+ S + + K+A VY+
Sbjct 2297 YLYSGSTFWKYNFDITEAKYACKDVLKNCN----ILTDFVVFNN-SGSNVTQVKNACVYF 2351
Query 2539 SQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELA 2598
SQL+C+PI L+D AL++ + + S + A+V+ S +F + +
Sbjct 2352 SQLLCKPIKLVDSALLASLN--VDFSANLHKAFVEVLSNSFGKDLSNCSNM--------- 2400
Query 2599 KGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE 2658
+ R+ + +DV ++ + +H D+ ++ S NN +++Y K E
Sbjct 2401 -------------NECRESLGLSDVPEEEFSAAVSEAHRYDVLISDVSFNNLIVSYAKPE 2447
Query 2659 -NMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPF 2717
+ D+ C+ A+ +N V NV ++W KD+++LSE+ RK I K I F
Sbjct 2448 EKLAVHDIANCMRVGAKVVNHNVLTKDNVPVVWLAKDFIALSEEARKYIVRTTKTKGINF 2507
Query 2718 RLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHD 2777
LT R + + T ++ K G + + F + + L L+ + + L
Sbjct 2508 MLTFNDRRMHLTIPTISVANKKGAGLPSLFTRLY--SFFWHLCVLIVVLFVATSLLDFSA 2565
Query 2778 GYTNEI-IGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAII 2835
T++ +K I++GV + DC N F+ W + + GS N + CP+V
Sbjct 2566 QVTSDTQYDFKYIENGVLKVFEKPLDCVHNAFVNFNEWHNAKFGSIPTNSRRCPIVVGTS 2625
Query 2836 TREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAE 2895
+PG+P V + G L F +C+ L + +C+ +
Sbjct 2626 DEV--RYIPGVPAGVF--LYGKSLIFAMSTIFGTSGLCFDDRGLTD-----PDSCIFNSA 2676
Query 2896 CTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVT 2954
CT G+ V YCY +++ + YS L P + Y LMDG+ I P G +R +
Sbjct 2677 CTTLSGIGGRNV-YCYREGVVDNAKLYSSLLPHSYYRLMDGNHIVLPEIITRGFGIRTIK 2735
Query 2955 TFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQP 3014
T YCR G C S+ G+C+ +V + S CG +L+ N+
Sbjct 2736 TQAMTYCRTGECIDSQAGVCVGLDRFFVYSK---TPGSDYVCGTGFFSLLFNVIGMFSNS 2792
Query 3015 VGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPA 3074
+ +S ++ ++A A + F KF+R+FG+ + V + L +++ +V
Sbjct 2793 IPVTVMSGQILLNCVVAFTAVMACFAFTKFKRLFGDMSFGVLSVGLCTVVNNL-SYVVTQ 2851
Query 3075 YSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFF 3134
S Y+ Y T S++ H+ + + + P+W+ Y+ C L+ F
Sbjct 2852 NSIGMLAYATLYFLCTK--GVRYSWVWHVGFAISYCFLAPWWVVLAYLICALLEFLPNLF 2909
Query 3135 NNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKY 3193
+ + +F G F +FE AA TF+L+ Y KL + + + +Y A YN+YKY
Sbjct 2910 KLKVSTQ-LFEGDKFVGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQYCASYNRYKY 2966
Query 3194 FSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKV 3253
+SG+ YR A HLAKA++DF+N D LY PP S S LQ+G RKMA PSG V
Sbjct 2967 YSGSASEADYRLACFAHLAKAMSDFANDHMDKLYTPPTVSYNST-LQAGLRKMAQPSGIV 3025
Query 3254 EGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNV 3313
EGC+V+V+ G TLNGLWL DTV CPRHVI + + +Y+ + H+F + +GN+
Sbjct 3026 EGCIVRVSYGNLTLNGLWLGDTVICPRHVIASNTTNV-IDYDHAMSLVRLHNFSISSGNM 3084
Query 3314 QLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN 3373
L VI SM+ LL +KV+ SN TP Y + ++PG +F++LACY+GS +GVY MR N
Sbjct 3085 FLGVISASMRGTLLHIKVNQSNVNTPNYTYKVLKPGDSFNILACYDGSAAGVYGVNMRTN 3144
Query 3374 HTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQA 3433
+TI+GSF++G+CGS G+NI+ V FCYMHH+EL +G H G+D++G YG + D+ T Q
Sbjct 3145 YTIRGSFISGACGSPGYNINNGVVEFCYMHHLELGSGCHVGSDMDGTMYGKYEDQPTLQI 3204
Query 3434 AGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPL 3493
G +T NV +WLY A+INGDRW+L+ + ++ +N A++ L +VD L
Sbjct 3205 EGASNLVTENVCSWLYGALINGDRWWLSSVSVGVDTYNEWALRNGMTALK--NVDCFSLL 3262
Query 3494 SAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKI 3552
A+TG+ V + A++++L N G++ILG T L DEFT +VV+Q GVT Q GK +
Sbjct 3263 VAKTGVDVGRLLASIQKLHGN-FGGKSILGCTSLCDEFTLSEVVKQMYGVTLQSGKVSRA 3321
Query 3553 VKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAF 3612
+ L FL L + S F++ P L I+ ++ MLLVKHK F
Sbjct 3322 FRNASIVCCLLFLF----LSEMLNHSKLFWINPGYITPVFLAIIVASSALMLLVKHKLLF 3377
Query 3613 LCLFLLPSLATVAYFNMV--YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLI 3670
L L+LLPSL V+ +N+ Y ++++ + G+ + + + ++
Sbjct 3378 LQLYLLPSLCIVSGYNIFKDYHFYTYMLEEFDY----KVPFGGFNVTGVLNISLCCFVMG 3433
Query 3671 LMTARTVYDDAARRVW-TLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
L T R + +++ ++ V+T++Y YY + + +S +NY + T
Sbjct 3434 LHTFR--FLQTPNKIFSYVVAVLTVLYTYYYS---TDVLGLILTSMSGFTNYWFIGTATY 3488
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
LA V + L + + ++ ++ +Y LGYC C Y+G +NR+ +LTLG Y+
Sbjct 3489 KLATY-----VLPHTSLLDSFDAIKAVVFLYLLLGYCNCVYYGSLYWINRFCKLTLGCYE 3543
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
+ VS EF+YM + GL P DA L++KL+G+GG+ IK+++VQSK++D+KCT+VVL
Sbjct 3544 FKVSAAEFKYMVANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQSKLTDLKCTNVVL 3603
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCE 3909
L L + + ++S+ WA CV LHN I L D A E +++LL+ LS A ++ L +
Sbjct 3604 LGCLSNMNIAANSREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFGVDELLD 3663
Query 3910 EMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFD 3969
++ + LQ++A+ + +LPSY AY TA+++YE A+ANG ++K+L+ ++NVAKSEFD
Sbjct 3664 SYFNDSSVLQSVAATYVNLPSYLAYETARQSYEDALANGSPPQLVKQLRHAMNVAKSEFD 3723
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
R+A+ QRKL++MA+QA +QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I++ A
Sbjct 3724 REASTQRKLDRMAEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILSLA 3783
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLS 4089
+DG VPL+IIP +A KL +VV D +Y YA +W + + D D K V
Sbjct 3784 KDGVVPLSIIPAVSATKLNIVVSDIESYSKIQREGCVHYAGVIWSVVDIKDNDGKPVHAK 3843
Query 4090 EINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYY 4149
E+ N +LAWPL + R +KLQNNE+ P ++Q A D NAL Y
Sbjct 3844 EVVTSNVESLAWPLFLNCER---IIKLQNNEIIPSKIKQRPIKAEGE-GVVADGNAL--Y 3897
Query 4150 NNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIK 4209
+N G F+ A +SD DLK ++ G+ I ELEPPC+F+ + P GP VKYLYF++
Sbjct 3898 SNEGGRTFMYAFISDKPDLKVVKWEFDGGSNAI--ELEPPCKFLVEAPSGPVVKYLYFVR 3955
Query 4210 GLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPIT 4269
LNNL RG VLG + ATVRLQAG TE NS++L+ CAFAVDP K Y D + SG +P+
Sbjct 3956 NLNNLRRGAVLGFIGATVRLQAGKQTEQATNSSLLTLCAFAVDPPKTYLDAVKSGHRPVG 4015
Query 4270 NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQI 4329
NCVKML +G GQAIT EA+ +Q+S+GGAS CLYCR H++HP+ GFC L+GKYVQ+
Sbjct 4016 NCVKMLANGSGNGQAITNGVEASTNQDSYGGASVCLYCRAHVEHPDMDGFCKLRGKYVQV 4075
Query 4330 PTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGFA 4381
P DP+ F L NTVC VCG W+ GC+CD+ ++QS D S +LN
Sbjct 4076 PLGTL-DPIRFVLENTVCKVCGCWQANGCTCDR---AVIQSVD-SGYLNECG 4122
Score = 271 bits (693), Expect = 8e-71, Method: Composition-based stats.
Identities = 83/364 (23%), Positives = 132/364 (36%), Gaps = 38/364 (10%)
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
+L E K ++V T D + HT + S TYGQQ G ++ VT +KP + V
Sbjct 1634 TLFEAKPVQVVVTQDQRSFHTVELSTSQTYGQQLGDCVVEDKKVTNLKPVSKDK--VVSV 1691
Query 1598 LPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLS 1654
+P+ D + F +HTLD + + V G ++ +DNNC+++
Sbjct 1692 VPNVDWDKHYGFVDAGIFHTLDHTMFV-----------FDNNVVNGKRVLRTSDNNCWIN 1740
Query 1655 SVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQ 1714
+V L LQ KF LQ+ + GD A F + + GE D T+ + +
Sbjct 1741 AVCLQLQFANAKFKPKGLQQLWESYCTGDVAMFVHWLYWITGVEKGEPSDAENTLNIISR 1800
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQY 1773
+ + +L C +T + V+ ++ LK G+ CV G
Sbjct 1801 FLKPQGSVEMLRATSTTCDGTCST----KRVVSTPVVNASVLKVGLDDGNCVHGLPLVDR 1856
Query 1774 LVQQESSFVMMSA---PPAEYKLQQGTFLCANEYT----GNYQCGHYTHITAKETLYRID 1826
+V + ++ + P + L YT GHYT + KE D
Sbjct 1857 VVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGVGHYT-VFDKEAKLMFD 1915
Query 1827 GAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPK--LDGYYKKDNAYY 1884
G L PVT V PV E++ LD ++
Sbjct 1916 GDVLKPCDLNVSPVTSVVVCNNKKIVVQDPV-------KRVELDASKFLDTMNVASEKFF 1968
Query 1885 TEQP 1888
T
Sbjct 1969 TFGD 1972
Score = 154 bits (388), Expect = 3e-35, Method: Composition-based stats.
Identities = 72/310 (23%), Positives = 116/310 (37%), Gaps = 22/310 (7%)
Query 1002 PVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAM 1061
V F Y N+ + + S N +VNAAN L HGGG+A AL+ T G +
Sbjct 1295 DVKPFLTYK----NIEFYQGE-LSALLSVNHDFVVNAANEQLSHGGGIAKALDDLTKGEL 1349
Query 1062 QKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDI 1121
Q S+ Y+ NG + VG L+ L+VVGP L KA F + +
Sbjct 1350 QVLSNQYVSRNGSIKVGSGVLIKCKE--HSILNVVGPRKGKHAAELLTKAYTFVFKQKGV 1407
Query 1122 LLAPLLSAGIFGAKPLQSLQVCVQTVRTQV---YIAVNDKALYEQVVMDYLDNLK----- 1173
L PLLS GIF +SL + V +V + + + L Q + +
Sbjct 1408 PLMPLLSVGIFKVPITESLAAFLACVGDRVCKCFCYTDKERLAIQNFVTSFQTEQPVEPL 1467
Query 1174 PRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFL--TNKLLL 1231
P ++ K + E ++ K + +L+ T+ + TN L
Sbjct 1468 PVIQEVKGVQLEKPVPDVKVENPCEPFRIEGDAKFYDLTPSMVQSLQVTRLVSFTNSDLC 1527
Query 1232 FADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSG-----DITCVVIPSKKAGGTT 1286
Q L G ++ + + G+ +T T V++P +
Sbjct 1528 LGSFVRDCDGYVQGSLGGAIANYKKSNPVLPAGNCVTLKCDGFISFTFVILPKEGDTNYE 1587
Query 1287 EMLSRALKKV 1296
+ +RA+ K
Sbjct 1588 KNFNRAIAKF 1597
Score = 64.7 bits (156), Expect = 3e-08, Method: Composition-based stats.
Identities = 38/194 (20%), Positives = 65/194 (34%), Gaps = 24/194 (12%)
Query 1626 ALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAA 1685
+ + GGL + + NNC++SS L+ LQ + ++ +Q AG +
Sbjct 1078 VKPDVFAFSYASYGGLKVLNQSSNNCWVSSALVQLQLTGL-LDSDEMQL----FNAGRVS 1132
Query 1686 NFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTT-----LT 1740
G LGDV + LL+ + S ++ C G + T
Sbjct 1133 PMVKRCYESQRAIFGSLGDVSACLESLLKDRDGMSITCTIDCGCGP-GVRVYENAIFRFT 1191
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMM-SAPPAEYKLQQGTFL 1799
++ MG +C + + Q + + + A + L
Sbjct 1192 PLKTAFPMGR------------CLICSKTLMHTITQMKGTGIFCRDATALDVDTLVVKPL 1239
Query 1800 CANEYTGNYQCGHY 1813
CA Y G GHY
Sbjct 1240 CAAVYVGAQDGGHY 1253
Score = 54.7 bits (130), Expect = 3e-05, Method: Composition-based stats.
Identities = 55/364 (15%), Positives = 114/364 (31%), Gaps = 50/364 (14%)
Query 653 ITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQ 712
+ GV V + + A ++ F+D V +++ + + +
Sbjct 750 LNGVVVFVTKKFRKAGALLQKLYNAFLDTVTSFIKVAGVAFKYCATCVPKIVIN------ 803
Query 713 SKGLYRQCIRGKEQLQLLMPLKAPKEVTFLE-GDSHDTVLTSEEVVLKNGELEALETPVD 771
+ + LQ+ P E + + V ++ LE E
Sbjct 804 -GCYHTVTRLFAKDLQI------PTEDGVADFNTFNHCVFPVNPTRIETDSLELEEV--- 853
Query 772 SFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-T 830
F + G V ++ S G + F+ KGG VT ++
Sbjct 854 DFVEPGVDGKLVILDDYSFYSDGTNYYP---SDGKGVVASCFKKKGGGV---VTISDEVQ 907
Query 831 VWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL 890
V + VR+ +E + D+ L + C E +++TL+ D+
Sbjct 908 VRTIDPVYKVRLEYEFE---DETLVKVC-----EKAIGTKLKVTGDWSNLLETLEKAMDV 959
Query 891 LTNMGIDLDEWSVATFYLFDDAG-----------EENFSSRMYCSFYPPDEEEEDDAECE 939
+ V ++++D+ G + SS F D+E + +
Sbjct 960 VR------QHLDVPDYFVYDEEGGTDLNLTIMVSQWPLSSDSEDDFKAVDDEPNANTDET 1013
Query 940 EEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTP 999
+ E + D +E V+ EE + + + +Q E++
Sbjct 1014 VDTFAEDVAETQNVQQDVTQDEVE-AVCDLVVKATEEGPIEHEELSEDQKEVQQALAFIE 1072
Query 1000 EEPV 1003
++PV
Sbjct 1073 DKPV 1076
Score = 40.1 bits (92), Expect = 0.66, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 52/179 (29%), Gaps = 38/179 (21%)
Query 180 GAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIA 239
G T VD CG DG P+ + G +DY + + + A
Sbjct 109 GGTTIPVDQFMCGADGAPV-------IQEGDWTF-----MDYFQ-DSNQFTLNGITYVKA 155
Query 240 WFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVI-QPRVEKKKTEG--- 295
W +R Y Q I+ + V + +K P+V K
Sbjct 156 WDVDRKPNDYAKQNVTCIRRITYITDH-----RHVLADGTTMKTARHPKVNKSVVLDSPF 210
Query 296 ----------FMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHC 344
FMG + V ++ H L+ C C W D+ K C
Sbjct 211 DQIYKEVGSPFMGNGSTF--VEMLKDPAFFH--ALITCE-CGRSEWTVGDW-KGYNSLC 263
>sp|P0C6W0|R1AB_BC512 Replicase polyprotein 1ab OS=Bat coronavirus
512/2005 OX=693999 GN=rep PE=3 SV=1
Length=6793
Score = 2585 bits (6700), Expect = 0.0, Method: Composition-based stats.
Identities = 784/2389 (33%), Positives = 1229/2389 (51%), Gaps = 132/2389 (6%)
Query 2012 GMDNLACESQQPTSEEVVE-NPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
G+D+ C P + VV N T+ + V +L
Sbjct 1841 GLDDGNCVHGLPLVDRVVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGV 1900
Query 2071 DLMAAYVENTSIT----IKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQA 2126
+ + + + KP +L+++ + + + P ++ FL
Sbjct 1901 GHYTVFDKEAKLMFDGDVLKPCDLNVSPVTSVVVCNNKKIVVQDPVKRVELDASKFLDTM 1960
Query 2127 AITTSNCAKRL--AQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPT---TIAKNSVK 2181
+ + R + Y+F+LL K + ++ A +P I K SVK
Sbjct 1961 NVASEKFFTFGDFVSRNIIVLIVYLFSLLAICFRALKKRDMKVMAGVPERTGIILKRSVK 2020
Query 2182 SVAKLCLDAGINYVKSPKFSKL-FTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYC 2240
NY F +L F L S+ L +L + F + + G P C
Sbjct 2021 ----------YNYKALKFFFRLKFQYIKVFLKFSLVLYTLYALMFMF-IRFTPVGTP-IC 2068
Query 2241 NGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGL 2300
+ Y NS+ D+C C ICL G + L + I + L IL L
Sbjct 2069 KRYTDGYANST-FDKNDYCGN-VLCKICLYGYEELSDFTHTRVIWQHLKD-PLIGNILPL 2125
Query 2301 AAEWVLAYMLFTKFFYLLGLSAIMQVFFGY--FASHFISNSWLMWFIISIVQMAPVSAMV 2358
+++ ++F FF +G++ + + A + N WL+ + P ++M
Sbjct 2126 F--YLVFLIIFGGFFVRIGITYFIMQYINAAGVALGYQDNVWLL-------HLLPFNSMG 2176
Query 2359 RMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ + I H++ GC +C+ C K + TRV TI+ G+ +SFYV ANGG
Sbjct 2177 NIIVVAFIVTRILLFLKHVLFGCDKPSCIACSKSAKLTRVPLQTILQGVTKSFYVNANGG 2236
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
+ FCK HN+ C++CD++ G TFI+D +A +LS K + PT ++ I+D V NG
Sbjct 2237 KKFCKKHNFFCVDCDSYGYGCTFINDVIAPELSNVTKLNVIPTGPATIIIDKVEFSNGFY 2296
Query 2479 HLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYY 2538
+LY K + + D L+ N + + +VF+ S + + K+A VY+
Sbjct 2297 YLYSGSTFWKYNFDITEAKYACKDVLKNCN----ILTDFVVFNN-SGSNVTQVKNACVYF 2351
Query 2539 SQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELA 2598
SQL+C+PI L+D AL++ + + S + A+V+ S +F + +
Sbjct 2352 SQLLCKPIKLVDSALLASLN--VDFSANLHKAFVEVLSNSFGKDLSNCSNM--------- 2400
Query 2599 KGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVE 2658
+ R+ + +DV ++ + +H D+ ++ S NN +++Y K E
Sbjct 2401 -------------NECRESLGLSDVPEEEFSAAVSEAHRYDVLISDVSFNNLIVSYAKPE 2447
Query 2659 -NMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPF 2717
+ D+ C+ A+ +N V NV ++W KD+++LSE+ RK I K I F
Sbjct 2448 EKLAVHDIANCMRVGAKVVNHNVLTKDNVPVVWLAKDFIALSEEARKYIVRTTKTKGINF 2507
Query 2718 RLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHD 2777
LT R + + T ++ K G + + F + + L L+ + + L
Sbjct 2508 MLTFNDRRMHLTIPTISVANKKGAGLPSLFTRLY--SFFWHLCVLIVVLFVATSLLDFSA 2565
Query 2778 GYTNEI-IGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAII 2835
T++ +K I++GV + DC N F+ W + + GS N + CP+V
Sbjct 2566 QVTSDTQYDFKYIENGVLKVFEKPLDCVHNAFVNFNEWHNAKFGSIPTNSRRCPIVVGTS 2625
Query 2836 TREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAE 2895
+PG+P V + G L F +C+ L + +C+ +
Sbjct 2626 DEV--RYIPGVPAGVF--LYGKSLIFAMSTIFGTSGLCFDDRGLTD-----PDSCIFNSA 2676
Query 2896 CTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVT 2954
CT G+ V YCY +++ + YS L P + Y LMDG+ I P G +R +
Sbjct 2677 CTTLSGIGGRNV-YCYREGVVDNAKLYSSLLPHSYYRLMDGNHIVLPEIITRGFGIRTIK 2735
Query 2955 TFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQP 3014
T YCR G C S+ G+C+ +V + S CG +L+ N+
Sbjct 2736 TQAMTYCRTGECIDSQAGVCVGLDRFFVYSK---TPGSDYVCGTGFFSLLFNVIGMFSNS 2792
Query 3015 VGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPA 3074
+ +S ++ ++A A + F KF+R+FG+ + V + L +++ +V
Sbjct 2793 IPVTVMSGQILLNCVVAFTAVMACFAFTKFKRLFGDMSFGVLSVGLCTVVNNL-SYVVTQ 2851
Query 3075 YSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFF 3134
S Y+ Y T S++ H+ + + + P+W+ Y+ C L+ F
Sbjct 2852 NSIGMLAYATLYFLCTK--GVRYSWVWHVGFAISYCFLAPWWVVLAYLICALLEFLPNLF 2909
Query 3135 NNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKY 3193
+ + +F G F +FE AA TF+L+ Y KL + + + +Y A YN+YKY
Sbjct 2910 KLKVSTQ-LFEGDKFVGSFESAASGTFVLDMHSYQKLANS--ISTEKLKQYCASYNRYKY 2966
Query 3194 FSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKV 3253
+SG+ YR A HLAKA++DF+N D LY PP S S LQ+G RKMA PSG V
Sbjct 2967 YSGSASEADYRLACFAHLAKAMSDFANDHMDKLYTPPTVSYNST-LQAGLRKMAQPSGIV 3025
Query 3254 EGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNV 3313
EGC+V+V+ G TLNGLWL DTV CPRHVI + + +Y+ + H+F + +GN+
Sbjct 3026 EGCIVRVSYGNLTLNGLWLGDTVICPRHVIASNTTNV-IDYDHAMSLVRLHNFSISSGNM 3084
Query 3314 QLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPN 3373
L VI SM+ LL +KV+ SN TP Y + ++PG +F++LACY+GS +GVY MR N
Sbjct 3085 FLGVISASMRGTLLHIKVNQSNVNTPNYTYKVLKPGDSFNILACYDGSAAGVYGVNMRTN 3144
Query 3374 HTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQA 3433
+TI+GSF++G+CGS G+NI+ V FCYMHH+EL +G H G+D++G YG + D+ T Q
Sbjct 3145 YTIRGSFISGACGSPGYNINNGVVEFCYMHHLELGSGCHVGSDMDGTMYGKYEDQPTLQI 3204
Query 3434 AGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPL 3493
G +T NV +WLY A+INGDRW+L+ + ++ +N A++ L +VD L
Sbjct 3205 EGASNLVTENVCSWLYGALINGDRWWLSSVSVGVDTYNEWALRNGMTALK--NVDCFSLL 3262
Query 3494 SAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKKI 3552
A+TG+ V + A++++L N G++ILG T L DEFT +VV+Q GVT Q GK +
Sbjct 3263 VAKTGVDVGRLLASIQKLHGN-FGGKSILGCTSLCDEFTLSEVVKQMYGVTLQSGKVSRA 3321
Query 3553 VKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAF 3612
+ L FL L + S F++ P L I+ ++ MLLVKHK F
Sbjct 3322 FRNASIVCCLLFLF----LSEMLNHSKLFWINPGYITPVFLAIIVASSALMLLVKHKLLF 3377
Query 3613 LCLFLLPSLATVAYFNMV--YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLI 3670
L L+LLPSL V+ +N+ Y ++++ + G+ + + + ++
Sbjct 3378 LQLYLLPSLCIVSGYNIFKDYHFYTYMLEEFDY----KVPFGGFNVTGVLNISLCCFVMG 3433
Query 3671 LMTARTVYDDAARRVW-TLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
L T R + +++ ++ V+T++Y YY + + +S +NY + T
Sbjct 3434 LHTFR--FLQTPNKIFSYVVAVLTVLYTYYYS---TDVLGLILTSMSGFTNYWFIGTATY 3488
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
LA V + L + + ++ ++ +Y LGYC C Y+G +NR+ +LTLG Y+
Sbjct 3489 KLATY-----VLPHTSLLDSFDAIKAVVFLYLLLGYCNCVYYGSLYWINRFCKLTLGCYE 3543
Query 3790 YLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVL 3849
+ VS EF+YM + GL P DA L++KL+G+GG+ IK+++VQSK++D+KCT+VVL
Sbjct 3544 FKVSAAEFKYMVANGLRAPTGVFDALILSLKLIGVGGRKTIKISSVQSKLTDLKCTNVVL 3603
Query 3850 LSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCE 3909
L L + + ++S+ WA CV LHN I L D A E +++LL+ LS A ++ L +
Sbjct 3604 LGCLSNMNIAANSREWAYCVDLHNKINLCNDAEAAQEMLLALLAFFLSKNSAFGVDELLD 3663
Query 3910 EMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFD 3969
++ + LQ++A+ + +LPSY AY TA+++YE A+ANG ++K+L+ ++NVAKSEFD
Sbjct 3664 SYFNDSSVLQSVAATYVNLPSYLAYETARQSYEDALANGSPPQLVKQLRHAMNVAKSEFD 3723
Query 3970 RDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNA 4029
R+A+ QRKL++MA+QA +QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I++ A
Sbjct 3724 REASTQRKLDRMAEQAASQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILSLA 3783
Query 4030 RDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLS 4089
+DG VPL+IIP +A KL +VV D +Y YA +W + + D D K V
Sbjct 3784 KDGVVPLSIIPAVSATKLNIVVSDIESYSKIQREGCVHYAGVIWSVVDIKDNDGKPVHAK 3843
Query 4090 EINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYY 4149
E+ N +LAWPL + R +KLQNNE+ P ++Q A D NAL Y
Sbjct 3844 EVVTSNVESLAWPLFLNCER---IIKLQNNEIIPSKIKQRPIKAEGE-GVVADGNAL--Y 3897
Query 4150 NNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIK 4209
+N G F+ A +SD DLK ++ G+ I ELEPPC+F+ + P GP VKYLYF++
Sbjct 3898 SNEGGRTFMYAFISDKPDLKVVKWEFDGGSNAI--ELEPPCKFLVEAPSGPVVKYLYFVR 3955
Query 4210 GLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPIT 4269
LNNL RG VLG + ATVRLQAG TE NS++L+ CAFAVDP K Y D + SG +P+
Sbjct 3956 NLNNLRRGAVLGFIGATVRLQAGKQTEQATNSSLLTLCAFAVDPPKTYLDAVKSGHRPVG 4015
Query 4270 NCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQI 4329
NCVKML +G GQAIT EA+ +Q+S+GGAS CLYCR H++HP+ GFC L+GKYVQ+
Sbjct 4016 NCVKMLANGSGNGQAITNGVEASTNQDSYGGASVCLYCRAHVEHPDMDGFCKLRGKYVQV 4075
Query 4330 PTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
P DP+ F L NTVC VCG W+ GC+CD+ ++QS D S +LN
Sbjct 4076 PLGTL-DPIRFVLENTVCKVCGCWQANGCTCDR---AVIQSVD-SGYLN 4119
Score = 271 bits (693), Expect = 1e-70, Method: Composition-based stats.
Identities = 83/364 (23%), Positives = 132/364 (36%), Gaps = 38/364 (10%)
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
+L E K ++V T D + HT + S TYGQQ G ++ VT +KP + V
Sbjct 1634 TLFEAKPVQVVVTQDQRSFHTVELSTSQTYGQQLGDCVVEDKKVTNLKPVSKDK--VVSV 1691
Query 1598 LPSDDTLRSEAF---EYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLS 1654
+P+ D + F +HTLD + + V G ++ +DNNC+++
Sbjct 1692 VPNVDWDKHYGFVDAGIFHTLDHTMFV-----------FDNNVVNGKRVLRTSDNNCWIN 1740
Query 1655 SVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQ 1714
+V L LQ KF LQ+ + GD A F + + GE D T+ + +
Sbjct 1741 AVCLQLQFANAKFKPKGLQQLWESYCTGDVAMFVHWLYWITGVEKGEPSDAENTLNIISR 1800
Query 1715 HANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQY 1773
+ + +L C +T + V+ ++ LK G+ CV G
Sbjct 1801 FLKPQGSVEMLRATSTTCDGTCST----KRVVSTPVVNASVLKVGLDDGNCVHGLPLVDR 1856
Query 1774 LVQQESSFVMMSA---PPAEYKLQQGTFLCANEYT----GNYQCGHYTHITAKETLYRID 1826
+V + ++ + P + L YT GHYT + KE D
Sbjct 1857 VVSVNGTVIITNVGDTPGKPVVATENLLLDGVSYTVFQDSTTGVGHYT-VFDKEAKLMFD 1915
Query 1827 GAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPK--LDGYYKKDNAYY 1884
G L PVT V PV E++ LD ++
Sbjct 1916 GDVLKPCDLNVSPVTSVVVCNNKKIVVQDPV-------KRVELDASKFLDTMNVASEKFF 1968
Query 1885 TEQP 1888
T
Sbjct 1969 TFGD 1972
Score = 154 bits (388), Expect = 3e-35, Method: Composition-based stats.
Identities = 72/310 (23%), Positives = 116/310 (37%), Gaps = 22/310 (7%)
Query 1002 PVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAM 1061
V F Y N+ + + S N +VNAAN L HGGG+A AL+ T G +
Sbjct 1295 DVKPFLTYK----NIEFYQGE-LSALLSVNHDFVVNAANEQLSHGGGIAKALDDLTKGEL 1349
Query 1062 QKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDI 1121
Q S+ Y+ NG + VG L+ L+VVGP L KA F + +
Sbjct 1350 QVLSNQYVSRNGSIKVGSGVLIKCKE--HSILNVVGPRKGKHAAELLTKAYTFVFKQKGV 1407
Query 1122 LLAPLLSAGIFGAKPLQSLQVCVQTVRTQV---YIAVNDKALYEQVVMDYLDNLK----- 1173
L PLLS GIF +SL + V +V + + + L Q + +
Sbjct 1408 PLMPLLSVGIFKVPITESLAAFLACVGDRVCKCFCYTDKERLAIQNFVTSFQTEQPVEPL 1467
Query 1174 PRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFL--TNKLLL 1231
P ++ K + E ++ K + +L+ T+ + TN L
Sbjct 1468 PVIQEVKGVQLEKPVPDVKVENPCEPFRIEGDAKFYDLTPSMVQSLQVTRLVSFTNSDLC 1527
Query 1232 FADINGKLYHDSQNMLRGEDMSFLEKDAPYMVGDVITSG-----DITCVVIPSKKAGGTT 1286
Q L G ++ + + G+ +T T V++P +
Sbjct 1528 LGSFVRDCDGYVQGSLGGAIANYKKSNPVLPAGNCVTLKCDGFISFTFVILPKEGDTNYE 1587
Query 1287 EMLSRALKKV 1296
+ +RA+ K
Sbjct 1588 KNFNRAIAKF 1597
Score = 64.7 bits (156), Expect = 3e-08, Method: Composition-based stats.
Identities = 38/194 (20%), Positives = 65/194 (34%), Gaps = 24/194 (12%)
Query 1626 ALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAA 1685
+ + GGL + + NNC++SS L+ LQ + ++ +Q AG +
Sbjct 1078 VKPDVFAFSYASYGGLKVLNQSSNNCWVSSALVQLQLTGL-LDSDEMQL----FNAGRVS 1132
Query 1686 NFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTT-----LT 1740
G LGDV + LL+ + S ++ C G + T
Sbjct 1133 PMVKRCYESQRAIFGSLGDVSACLESLLKDRDGMSITCTIDCGCGP-GVRVYENAIFRFT 1191
Query 1741 GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMM-SAPPAEYKLQQGTFL 1799
++ MG +C + + Q + + + A + L
Sbjct 1192 PLKTAFPMGR------------CLICSKTLMHTITQMKGTGIFCRDATALDVDTLVVKPL 1239
Query 1800 CANEYTGNYQCGHY 1813
CA Y G GHY
Sbjct 1240 CAAVYVGAQDGGHY 1253
Score = 54.7 bits (130), Expect = 3e-05, Method: Composition-based stats.
Identities = 55/364 (15%), Positives = 114/364 (31%), Gaps = 50/364 (14%)
Query 653 ITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQ 712
+ GV V + + A ++ F+D V +++ + + +
Sbjct 750 LNGVVVFVTKKFRKAGALLQKLYNAFLDTVTSFIKVAGVAFKYCATCVPKIVIN------ 803
Query 713 SKGLYRQCIRGKEQLQLLMPLKAPKEVTFLE-GDSHDTVLTSEEVVLKNGELEALETPVD 771
+ + LQ+ P E + + V ++ LE E
Sbjct 804 -GCYHTVTRLFAKDLQI------PTEDGVADFNTFNHCVFPVNPTRIETDSLELEEV--- 853
Query 772 SFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED-T 830
F + G V ++ S G + F+ KGG VT ++
Sbjct 854 DFVEPGVDGKLVILDDYSFYSDGTNYYP---SDGKGVVASCFKKKGGGV---VTISDEVQ 907
Query 831 VWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDL 890
V + VR+ +E + D+ L + C E +++TL+ D+
Sbjct 908 VRTIDPVYKVRLEYEFE---DETLVKVC-----EKAIGTKLKVTGDWSNLLETLEKAMDV 959
Query 891 LTNMGIDLDEWSVATFYLFDDAG-----------EENFSSRMYCSFYPPDEEEEDDAECE 939
+ V ++++D+ G + SS F D+E + +
Sbjct 960 VR------QHLDVPDYFVYDEEGGTDLNLTIMVSQWPLSSDSEDDFKAVDDEPNANTDET 1013
Query 940 EEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTP 999
+ E + D +E V+ EE + + + +Q E++
Sbjct 1014 VDTFAEDVAETQNVQQDVTQDEVE-AVCDLVVKATEEGPIEHEELSEDQKEVQQALAFIE 1072
Query 1000 EEPV 1003
++PV
Sbjct 1073 DKPV 1076
Score = 40.1 bits (92), Expect = 0.69, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 52/179 (29%), Gaps = 38/179 (21%)
Query 180 GAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIA 239
G T VD CG DG P+ + G +DY + + + A
Sbjct 109 GGTTIPVDQFMCGADGAPV-------IQEGDWTF-----MDYFQ-DSNQFTLNGITYVKA 155
Query 240 WFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVI-QPRVEKKKTEG--- 295
W +R Y Q I+ + V + +K P+V K
Sbjct 156 WDVDRKPNDYAKQNVTCIRRITYITDH-----RHVLADGTTMKTARHPKVNKSVVLDSPF 210
Query 296 ----------FMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHC 344
FMG + V ++ H L+ C C W D+ K C
Sbjct 211 DQIYKEVGSPFMGNGSTF--VEMLKDPAFFH--ALITCE-CGRSEWTVGDW-KGYNSLC 263
>sp|P0C6V6|R1A_PEDV7 Replicase polyprotein 1a OS=Porcine epidemic
diarrhea virus (strain CV777) OX=229032 GN=1a PE=1 SV=1
Length=4117
Score = 2566 bits (6650), Expect = 0.0, Method: Composition-based stats.
Identities = 774/2434 (32%), Positives = 1215/2434 (50%), Gaps = 149/2434 (6%)
Query 1995 PVDTSNSFEVLAVEDTQGMD---NLACESQQPTSEEVVENPTIQKEVIECDVK------T 2045
P D+ N+ +L+ S+ VV P + V++ V+
Sbjct 1780 PSDSENALNMLSKYIVPAGSVTIERVTHDGCCCSKRVVTAPVVNASVLKLGVEDGLCPHG 1839
Query 2046 TEVVGNVILKPSDEGVKVTQELG--HEDLMAAYVENTSITIKKPNELSLALGLKTIATHG 2103
+G V++ +G + +G +++ S T N + +G T+ HG
Sbjct 1840 LNYIGKVVVV---KGTTIVVNVGKPVVAPSHLFLKGVSYTTFLDNG-NGVVGHYTVFDHG 1895
Query 2104 IAAINS----VPWSKILAYVKPFLGQAAITTSNCAKRLAQRV----FNNYMPYVFTLLFQ 2155
++ VP ++ V + + + M Y F
Sbjct 1896 TGMVHDGDAFVPGDLNVSPVTNVVVSEQTAVVIKDPVKKAELDATKLLDTMNYASERFFS 1955
Query 2156 LCTFTKSTNSRIRASLPTTI-------AKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAM 2208
F + + + + K VK +A + GI KS +++
Sbjct 1956 FGDFMSRNLITVFLYILSILGLCFRAFRKRDVKVLAGVPQRTGIILRKSMRYNAKALGVF 2015
Query 2209 WLL--LLSICLGSL------ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCE 2260
+ L LG + + + G+P C+ V Y NSS ++C
Sbjct 2016 FKLKLYWFKVLGKFSLGIYALYALLFMTIRFTPIGSP-VCDDVVAGYANSS-FDKNEYC- 2072
Query 2261 GSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYM-LFTKFFYLLG 2319
S C +CL G L + + + + D I + + LA++ +F +
Sbjct 2073 NSVICKVCLYGYQELSDFSHTQVVWQHLR----DPLIGNVMPFFYLAFLAIFGGVYVKAI 2128
Query 2320 LSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
+ + F+ +WF+ Q+ P + F + H+
Sbjct 2129 TLYFIFQYLNSLGV-FLGLQQSIWFL----QLVPFDVFGDEIVVFFIVTRVLMFIKHVCL 2183
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC ++C+ C K R RV TI G +SFYV+ANGG FCK HN+ CLNCD++ G
Sbjct 2184 GCDKASCVACSKSARLKRVPVQTIFQGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGC 2243
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI+D +A ++ K + PT ++ ++D V NG +LY K S +
Sbjct 2244 TFINDVIATEVGNVVKLNVQPTGPATILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYT 2303
Query 2500 NLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGD 2559
+ L+ S+ + IVF+ + + K+A VY+SQ++C+P+ L+D AL++ +
Sbjct 2304 CKEALK----NCSIITDFIVFNNNG-SNVNQVKNACVYFSQMLCKPVKLVDSALLASL-- 2356
Query 2560 STEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGV-LSTFVSAARQGV 2618
S + + A+V S +F + + + + D V L TF +A +
Sbjct 2357 SVDFGASLHSAFVSVLSNSFGKDLSSCNDM-----QDCKSTLGFDDVPLDTFNAAVAE-- 2409
Query 2619 VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTP-RDLGACIDCNARHIN 2677
+H D+ +T S NNF +Y K E P D+ C+ A+ +N
Sbjct 2410 ----------------AHRYDVLLTDMSFNNFTTSYAKPEEKFPVHDIATCMRVGAKIVN 2453
Query 2678 AQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISL 2737
V ++ ++W V+D+++LSE+ RK I K I F LT R + T I+
Sbjct 2454 HNVLVKDSIPVVWLVRDFIALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIAN 2513
Query 2738 KGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYT----NEIIGYKAIQDGV 2793
K G + + K+ LC+ +IV LS D T + +K I+ G
Sbjct 2514 KKGAGLPSFSKVKKFFWFLCL------FIVAAFFALSFLDFSTQVSSDSDYDFKYIESGQ 2567
Query 2794 TRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
+ + C N FD W + G N+ SCP+V + + VPG+P V
Sbjct 2568 LKTFDNPLSCVHNVFINFDQWHDAKFGFTPVNNPSCPIVVGV--SDEARTVPGIPAGVY- 2624
Query 2853 AINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD 2912
+ G L F +C+ S + + AC+ + CT G V YCY
Sbjct 2625 -LAGKTLVFAINTIFGTSGLCFDASGVAD-----KGACIFNSACTTLSGLGGTAV-YCYK 2677
Query 2913 TNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEV 2971
L+EG+ YSEL P + Y ++DG+ + P G +R + T YCR G C +S
Sbjct 2678 NGLVEGAKLYSELAPHSYYKMVDGNAVSLPEIISRGFGIRTIRTKAMTYCRVGQCVQSAE 2737
Query 2972 GICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIA 3031
G+C +V N E + S CG L+ N+ + + V +S ++ IIA
Sbjct 2738 GVCFGADRFFVYNAE---SGSDFVCGTGLFTLLMNVISVFSKTVPVTVLSGQILFNCIIA 2794
Query 3032 ILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTF 3091
+ + F KF+R+FG+ + V L++ + +V + Y+ Y T
Sbjct 2795 FVAVAVCFLFTKFKRMFGDMSVGVFTVGACTLLN-NVSYIVTQNTLGMLGYATLYFLCTK 2853
Query 3092 YFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-S 3150
++ HL + + I P+W+ +Y F + F + + +F G F
Sbjct 2854 --GVRYMWIWHLGFLISYILIAPWWVLMVYAFSAIFEFMPNLFKLKVSTQ-LFEGDKFVG 2910
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
+FE AA TF+L+ Y +L + + + +Y + YNKYKY+SG+ YR A H
Sbjct 2911 SFENAAAGTFVLDMHAYERLANS--ISTEKLRQYASTYNKYKYYSGSASEADYRLACFAH 2968
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKA+ D++++ D LY PP S S LQ+G RKMA PSG VE C+V+V G LNGL
Sbjct 2969 LAKAMMDYASNHNDTLYTPPTVSYNST-LQAGLRKMAQPSGVVEKCIVRVCYGNMALNGL 3027
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WL D V CPRHVI ++ +Y+ L H+F + +GNV L V+ +M+ LL++K
Sbjct 3028 WLGDIVMCPRHVIASSTT-STIDYDYALSVLRLHNFSISSGNVFLGVVSATMRGALLQIK 3086
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
V+ +N TPKY + ++PG++F++LACY+G+ +GVY MR N+TI+GSF+NG+CGS G+
Sbjct 3087 VNQNNVHTPKYTYRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGY 3146
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NI+ V FCY+H +EL +G H G+DL+G YG + D+ T Q G + T NVLA+LYA
Sbjct 3147 NINNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTENVLAFLYA 3206
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
A+ING W+L+ ++ FN A+ + + D L+A+TG+ V + A+++
Sbjct 3207 ALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVG--NTDCFSILAAKTGVDVQRLLASIQS 3264
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
L +N G+ ILG T L DEFT +VVRQ GV QG + + + + +L+ +
Sbjct 3265 LHKN-FGGKQILGHTSLTDEFTTGEVVRQMYGVNLQGGY--VSRACRNVLLVGSFLT-FF 3320
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
+ ++ FF+V P + +++ M +KHK F +FL+P+L + N+
Sbjct 3321 WSELVSYTKFFWVNPGYVTPMFACLSLLSSLLMFTLKHKTLFFQVFLIPALIVTSCINLA 3380
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTV--YDDAARRVWTL 3688
+ + + SL G+ + V V+ IL T ++ A V +
Sbjct 3381 FDVEVY--NYLAEHFDYHVSLMGFNAQGLVNIFVCFVVTILHGTYTWRFFNTPASSVTYV 3438
Query 3689 MNVITLVYKVYYGNA-LDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLF 3747
+ ++T Y +Y + L A++++A SVT N V + + + V++ + + P
Sbjct 3439 VALLTAAYNYFYASDILSCAMTLFA---SVTGN--WFVGAVCY--KVAVYMALRF-PTFV 3490
Query 3748 ITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLP 3807
++ +M Y LGY CC++G+ NR+F++++GVYDY VS EF+YM + GL
Sbjct 3491 AIFGDIKSVMFCYLVLGYFTCCFYGILYWFNRFFKVSVGVYDYTVSAAEFKYMVANGLRA 3550
Query 3808 PKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQ 3867
P ++D+ L+ KL+GIGG+ IK+++VQSK++D+KC++VVLL L + V ++S WA
Sbjct 3551 PTGTLDSLLLSAKLIGIGGERNIKISSVQSKLTDIKCSNVVLLGCLSSMNVSANSTEWAY 3610
Query 3868 CVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSS 3927
CV LHN I L D +A E +++LL+ LS A ++ L E ++ + LQ++AS +
Sbjct 3611 CVDLHNKINLCNDPEKAQEMLLALLAFFLSKNSAFGLDDLLESYFNDNSMLQSVASTYVG 3670
Query 3928 LPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMT 3987
LPSY Y A++ YE AV NG ++K+L+ ++NVAKSEFDR+A+ QRKL++MA+QA
Sbjct 3671 LPSYVIYENARQQYEDAVNNGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAAA 3730
Query 3988 QMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKL 4047
QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N A+DG VPL++IP +A KL
Sbjct 3731 QMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVPLSVIPAVSATKL 3790
Query 4048 MVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTA 4107
+V D +Y YA +W I + D D K+V + E+ N+ +L+WPL++
Sbjct 3791 NIVTSDIDSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQNAESLSWPLVLGC 3850
Query 4108 LRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQD 4167
R VKLQNNE+ P L+Q S A A YNN G F+ A +SD D
Sbjct 3851 ER---IVKLQNNEIIPGKLKQRSIKAEGDGIV---GEGKALYNNEGGRTFMYAFISDKPD 3904
Query 4168 LKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATV 4227
L+ ++ G TI ELEPP +F+ D+P G ++KYLYF++ LN L RG VLG + ATV
Sbjct 3905 LRVVKWEFDGGCNTI--ELEPPRKFLVDSPNGAQIKYLYFVRNLNTLRRGAVLGYIGATV 3962
Query 4228 RLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITV 4287
RLQAG TE NS++L+ CAFAVDPAK Y D + SG +P+ NCVKML +G GQA+T
Sbjct 3963 RLQAGKQTEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTN 4022
Query 4288 TPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVC 4347
EA+ +Q+S+GGAS CLYCR H++HP+ GFC LKGKYVQ+P DP+ F L N VC
Sbjct 4023 GVEASTNQDSYGGASVCLYCRAHVEHPSMDGFCRLKGKYVQVPLGTV-DPIRFVLENDVC 4081
Query 4348 TVCGMWKGYGCSCDQLREPLMQSADASTFLNGFA 4381
VCG W GC+CD+ +MQS D + +LN +
Sbjct 4082 KVCGCWLSNGCTCDR---SIMQSTDMA-YLNEYG 4111
Score = 287 bits (735), Expect = 1e-75, Method: Composition-based stats.
Identities = 257/1530 (17%), Positives = 462/1530 (30%), Gaps = 213/1530 (14%)
Query 426 RASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTS 485
R ++ + T + VE N +L+ + E V +N G + + +A S
Sbjct 518 RYTSLVVGSTTKVVSKRVENANVNLV--VVDEDVTLNTTGRTVVVDGLAFF-----ESDG 570
Query 486 AFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIR 545
+ + +C V + P+ P+ V
Sbjct 571 FYRHLADADVVIEHPVYKSACELKPVFECDPIPD---------FPLPV-AASVAELCVQT 620
Query 546 SIFARTLDAANHSIPDLQRAAVT-ILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGG 604
+ + + + + R I + ++ V+ V DL T ++ +
Sbjct 621 DLLLKNYNTPYKTYSCVVRGDKCCITCTLQFKAPSYVEDAVNFVDLCTKNIGTAGFHEFY 680
Query 605 LVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLK--DAWEILKFLITGVFDI--- 659
+ Q L L T FE + L+ D I + ITG+ +
Sbjct 681 ITAHEQQDLQGFLTTCCTM--SGFECFMPTIPQCPAVLEEIDGGSIWRSFITGLNTMWDF 738
Query 660 ---------VKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFI 710
+ G + + K ++ N L ++ + +AG + I
Sbjct 739 CKRLKVSFGLDGIVVTVARKFKRLGALLAEMYNTYLSTVVENLVLAGVSFKYYATSVPKI 798
Query 711 AQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPV 770
+ Q+ + K FL H V E ELE
Sbjct 799 VLGGCFHSVKSVFASVFQIPVQAGIEKFKVFLN-CVHPVVPRVIETSFV--ELEE----- 850
Query 771 DSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED- 829
+F A+ G V+G + G F+ KGG +K F ++
Sbjct 851 TTFKPPALNGGIAIVDGFAFYYDGTLYYP---TDGNSVVPICFKKKGGGDVK---FSDEV 904
Query 830 TVWEVQGYKNVRITFELD-ERVDKVLNEKCS------------------VYTVESG-TEV 869
+V + V + FE + E + VLN+ V EV
Sbjct 905 SVKTIDPVYKVSLEFEFESETIMAVLNKAVGNRIKVTGGWDDVVEYINVAIEVLKDHVEV 964
Query 870 TEFACVVAEAVVKTLQPVS--------DLLTNMGIDLDEWSVATFYLFDDAGEENFSSRM 921
++ E PV D ++ +D++ + A D G+E SS
Sbjct 965 PKYYIYDEEGGTDPNLPVMVSQWPLNDDTISQDLLDVEVVTDAPI---DSEGDEVDSS-- 1019
Query 922 YCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDW 981
P + ++E ++ + E +E + L F + ++ D+
Sbjct 1020 ----APEKVADVANSEPGDDGLPVAPETNVESEVEEVAATLSFIKDTPSTVTKDPFAFDF 1075
Query 982 LDDT-------------TEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQ 1028
+ + ++ + ++P + ++ V KC + K
Sbjct 1076 VSYGGLKVLRQSHNNCWVTSTLVQLQLLGIVDDPAMELFSAGRVGPMVR-KCYESQKAIL 1134
Query 1029 SANPMVIVNAANIHLKHG--------GGVAGALNKATNGAMQKES-DDYIKLNGPLTVGG 1079
+ V+A L V G T + + P G
Sbjct 1135 GSLGD--VSACLESLTKDLHTLKITCSVVCG---CGTGERIYEGCAFRMTPTLEPFPYG- 1188
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
+C L +VG + + +++ PL +A G
Sbjct 1189 ACAQCAQVLMHTFKSIVG--------TGIFCRDTTALSLDSLVVKPLCAAAFIGKDSGHY 1240
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLK---PRVEAPKQEEPPNTEDSKTEEKS 1196
+ + + Y+ + + ++ P V A P K+
Sbjct 1241 VTNFYDAAMA-IDGYGRHQIKYDTLNTICVKDVNWTAPLVPAVDSVVEPVV-KPFYSYKN 1298
Query 1197 VVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLE 1256
V D +K D V K I + ++ ML+ +++
Sbjct 1299 VDFYQGDFSDLVKLPCDFV-VNAANEKLSHG-----GGIAKAIDVYTKGMLQKCSNDYIK 1352
Query 1257 KDAPYMVGDVITSGD----ITCVVIPSKKAGGTTEMLSRALKKVPVDE--YITTYPGQGC 1310
P VG + + VV P +K E+L +A K V + +T G
Sbjct 1353 AHGPIKVGRGVMLEALGLKVFNVVGP-RKGKHAPELLVKAYKSVFANSGVALTPLISVGI 1411
Query 1311 AGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMD 1370
LEE+ +A C + + + E + L + + E P+ D
Sbjct 1412 FSVPLEESLSAFLACVGDRHCKCFCYGDKEREAIIKYMDGLVDAI-FKEALVDTTPVQED 1470
Query 1371 VRAIM-ATIQRKYKGIKIQ----------EGIVDYGVR--FFFYTSKEPVASIITKLNSL 1417
V+ + + ++ +I+ EG++ G F S S+ LN +
Sbjct 1471 VQQVSQKPVLPNFEPFRIEGAHAFYECNPEGLMSLGADKLVLFTNSNLDFCSVGKCLNDV 1530
Query 1418 NEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF 1477
+ I A C+ +S V ++G K
Sbjct 1531 TSGALLEAINVFKKSNKTVPAGNCV---TLDCANMISITMVVLPFDGDANY-DKNYARAV 1586
Query 1478 VETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLL 1537
V+ L G + L V+ K+ + ++ V D E
Sbjct 1587 VKVSKLKG----------KLVLAVDDATLYSKLSHLSVLGFVSTPDDVE----------- 1625
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
K++ + T D ++ V+ + TYGQQ GP ++ VT KP V V
Sbjct 1626 RFYANKSVVIKVTEDTRSVKAVKVESTATYGQQIGPCLVNDTVVTDNKPVVADV--VAKV 1683
Query 1598 LPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTK-KWKFPQVGGLTSIKWADNNCYLSSV 1656
+P+ + F+ L+HT + V G IK DNNC+++
Sbjct 1684 VPNANWDSHYGFDKAGEF---------HMLDHTGFTFPSEVVNGRRVIKTTDNNCWVNVT 1734
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQH- 1715
L LQ +F + LQ + GD A F + + G+ D + L ++
Sbjct 1735 CLQLQFARFRFKSAGLQAMWESYCTGDVAMFVHWLYWLTGVDKGQPSDSENALNMLSKYI 1794
Query 1716 --ANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQ 1772
A + +RV + C C ++ T V A + LK GV C G +
Sbjct 1795 VPAGSVTIERVTHDGC-CCSKRVVTAPVVNASV---------LKLGVEDGLCPHGLNYIG 1844
Query 1773 YLVQQESSFVMMSAPPAEYKLQQGTFLCANEYT-----GNYQCGHYTHITAKETLYRIDG 1827
+V + + +++ FL YT GN GHYT + DG
Sbjct 1845 KVVVVKGTTIVV-NVGKPVVAPSHLFLKGVSYTTFLDNGNGVVGHYTVFDHGTGMVH-DG 1902
Query 1828 AHLTKMSEYKGPVTDVFYKETSYTTTIKPV 1857
PVT+V E + PV
Sbjct 1903 DAFVPGDLNVSPVTNVVVSEQTAVVIKDPV 1932
Score = 63.2 bits (152), Expect = 7e-08, Method: Composition-based stats.
Identities = 49/260 (19%), Positives = 83/260 (32%), Gaps = 29/260 (11%)
Query 1632 KWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI 1691
+ F GGL ++ + NNC+++S L+ LQ L + + A AG
Sbjct 1072 AFDFVSYGGLKVLRQSHNNCWVTSTLVQLQLLGIVDDP-----AMELFSAGRVGPMVRKC 1126
Query 1692 LAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+G LGDV + L + +L + K +VVC CG G + T
Sbjct 1127 YESQKAILGSLGDVSACLESLTK--DLHTLKITCSVVCG-CGTGERIYEG---CAFRMTP 1180
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA-EYKLQQGTFLCANEYTGNYQC 1810
+ + C + + + A LCA + G
Sbjct 1181 TLEPF--PYGACAQCAQVLMHTFKSIVGTGIFCRDTTALSLDSLVVKPLCAAAFIGK-DS 1237
Query 1811 GHYT--HITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTE 1868
GHY A + + + V DV + P+ +D V
Sbjct 1238 GHYVTNFYDAAMAIDGYGRHQIKYDTLNTICVKDVNWTA--------PLVPAVDSVVEPV 1289
Query 1869 IEPKLDGYYKKDNAYYTEQP 1888
++P +Y N + +
Sbjct 1290 VKP----FYSYKNVDFYQGD 1305
Score = 61.7 bits (148), Expect = 2e-07, Method: Composition-based stats.
Identities = 49/212 (23%), Positives = 72/212 (34%), Gaps = 43/212 (20%)
Query 172 ELTRELNGGAVTRYVDNNFCGPDGYPLD-----CIKDFLARAGKSMCTLSEQLDYIESKR 226
ELT GG + VD CG DG P+ DF A +S+
Sbjct 102 ELTFGRRGGNIVP-VDQYMCGADGKPVLQESEWEYTDFFA----------------DSED 144
Query 227 GVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVI-Q 285
G + AW ERSD SY Q IKS T++ F + +KV
Sbjct 145 GQLNIAGITYVKAWIVERSDVSYASQNLTSIKSITYCSTYE-----HTFLDGTAMKVART 199
Query 286 PRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNHCDEVSWQTC 334
P+++K + ++Y +N + L +KC C W
Sbjct 200 PKIKKNVV--LSEPLATIYREIGSPFVDNGSDARSIIRRPVFLHAFVKCK-CGSYHWTVG 256
Query 335 DFLKATCEHCGTENLVIEGPTTCGYLPTNAVV 366
D+ CG + +C +P + VV
Sbjct 257 DWTSYVSTCCGFK-CKPVLVASCSAMPGSVVV 287
>sp|P0C6Y4|R1AB_PEDV7 Replicase polyprotein 1ab OS=Porcine epidemic
diarrhea virus (strain CV777) OX=229032 GN=rep PE=1 SV=1
Length=6781
Score = 2565 bits (6647), Expect = 0.0, Method: Composition-based stats.
Identities = 774/2431 (32%), Positives = 1214/2431 (50%), Gaps = 149/2431 (6%)
Query 1995 PVDTSNSFEVLAVEDTQGMD---NLACESQQPTSEEVVENPTIQKEVIECDVK------T 2045
P D+ N+ +L+ S+ VV P + V++ V+
Sbjct 1780 PSDSENALNMLSKYIVPAGSVTIERVTHDGCCCSKRVVTAPVVNASVLKLGVEDGLCPHG 1839
Query 2046 TEVVGNVILKPSDEGVKVTQELG--HEDLMAAYVENTSITIKKPNELSLALGLKTIATHG 2103
+G V++ +G + +G +++ S T N + +G T+ HG
Sbjct 1840 LNYIGKVVVV---KGTTIVVNVGKPVVAPSHLFLKGVSYTTFLDNG-NGVVGHYTVFDHG 1895
Query 2104 IAAINS----VPWSKILAYVKPFLGQAAITTSNCAKRLAQRV----FNNYMPYVFTLLFQ 2155
++ VP ++ V + + + M Y F
Sbjct 1896 TGMVHDGDAFVPGDLNVSPVTNVVVSEQTAVVIKDPVKKAELDATKLLDTMNYASERFFS 1955
Query 2156 LCTFTKSTNSRIRASLPTTI-------AKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAM 2208
F + + + + K VK +A + GI KS +++
Sbjct 1956 FGDFMSRNLITVFLYILSILGLCFRAFRKRDVKVLAGVPQRTGIILRKSMRYNAKALGVF 2015
Query 2209 WLL--LLSICLGSL------ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCE 2260
+ L LG + + + G+P C+ V Y NSS ++C
Sbjct 2016 FKLKLYWFKVLGKFSLGIYALYALLFMTIRFTPIGSP-VCDDVVAGYANSS-FDKNEYC- 2072
Query 2261 GSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYM-LFTKFFYLLG 2319
S C +CL G L + + + + D I + + LA++ +F +
Sbjct 2073 NSVICKVCLYGYQELSDFSHTQVVWQHLR----DPLIGNVMPFFYLAFLAIFGGVYVKAI 2128
Query 2320 LSAIMQVFFGYFASHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMD 2379
+ + F+ +WF+ Q+ P + F + H+
Sbjct 2129 TLYFIFQYLNSLGV-FLGLQQSIWFL----QLVPFDVFGDEIVVFFIVTRVLMFIKHVCL 2183
Query 2380 GCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGS 2439
GC ++C+ C K R RV TI G +SFYV+ANGG FCK HN+ CLNCD++ G
Sbjct 2184 GCDKASCVACSKSARLKRVPVQTIFQGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGC 2243
Query 2440 TFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFV 2499
TFI+D +A ++ K + PT ++ ++D V NG +LY K S +
Sbjct 2244 TFINDVIATEVGNVVKLNVQPTGPATILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYT 2303
Query 2500 NLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGD 2559
+ L+ S+ + IVF+ + + K+A VY+SQ++C+P+ L+D AL++ +
Sbjct 2304 CKEALK----NCSIITDFIVFNNNG-SNVNQVKNACVYFSQMLCKPVKLVDSALLASL-- 2356
Query 2560 STEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGV-LSTFVSAARQGV 2618
S + + A+V S +F + + + + D V L TF +A +
Sbjct 2357 SVDFGASLHSAFVSVLSNSFGKDLSSCNDM-----QDCKSTLGFDDVPLDTFNAAVAE-- 2409
Query 2619 VDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKVENMTP-RDLGACIDCNARHIN 2677
+H D+ +T S NNF +Y K E P D+ C+ A+ +N
Sbjct 2410 ----------------AHRYDVLLTDMSFNNFTTSYAKPEEKFPVHDIATCMRVGAKIVN 2453
Query 2678 AQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISL 2737
V ++ ++W V+D+++LSE+ RK I K I F LT R + T I+
Sbjct 2454 HNVLVKDSIPVVWLVRDFIALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIAN 2513
Query 2738 KGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYT----NEIIGYKAIQDGV 2793
K G + + K+ LC+ +IV LS D T + +K I+ G
Sbjct 2514 KKGAGLPSFSKVKKFFWFLCL------FIVAAFFALSFLDFSTQVSSDSDYDFKYIESGQ 2567
Query 2794 TRDIISTDDCFANKHAGFDAWFSQRGGS-YKNDKSCPVVAAIITREIGFIVPGLPGTVLR 2852
+ + C N FD W + G N+ SCP+V + + VPG+P V
Sbjct 2568 LKTFDNPLSCVHNVFINFDQWHDAKFGFTPVNNPSCPIVVGV--SDEARTVPGIPAGVY- 2624
Query 2853 AINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD 2912
+ G L F +C+ S + + AC+ + CT G V YCY
Sbjct 2625 -LAGKTLVFAINTIFGTSGLCFDASGVAD-----KGACIFNSACTTLSGLGGTAV-YCYK 2677
Query 2913 TNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEG-SVRVVTTFDAEYCRHGTCERSEV 2971
L+EG+ YSEL P + Y ++DG+ + P G +R + T YCR G C +S
Sbjct 2678 NGLVEGAKLYSELAPHSYYKMVDGNAVSLPEIISRGFGIRTIRTKAMTYCRVGQCVQSAE 2737
Query 2972 GICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIA 3031
G+C +V N E + S CG L+ N+ + + V +S ++ IIA
Sbjct 2738 GVCFGADRFFVYNAE---SGSDFVCGTGLFTLLMNVISVFSKTVPVTVLSGQILFNCIIA 2794
Query 3032 ILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTF 3091
+ + F KF+R+FG+ + V L++ + +V + Y+ Y T
Sbjct 2795 FVAVAVCFLFTKFKRMFGDMSVGVFTVGACTLLN-NVSYIVTQNTLGMLGYATLYFLCTK 2853
Query 3092 YFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-S 3150
++ HL + + I P+W+ +Y F + F + + +F G F
Sbjct 2854 --GVRYMWIWHLGFLISYILIAPWWVLMVYAFSAIFEFMPNLFKLKVSTQ-LFEGDKFVG 2910
Query 3151 TFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCH 3210
+FE AA TF+L+ Y +L + + + +Y + YNKYKY+SG+ YR A H
Sbjct 2911 SFENAAAGTFVLDMHAYERLANS--ISTEKLRQYASTYNKYKYYSGSASEADYRLACFAH 2968
Query 3211 LAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL 3270
LAKA+ D++++ D LY PP S S LQ+G RKMA PSG VE C+V+V G LNGL
Sbjct 2969 LAKAMMDYASNHNDTLYTPPTVSYNST-LQAGLRKMAQPSGVVEKCIVRVCYGNMALNGL 3027
Query 3271 WLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLK 3330
WL D V CPRHVI ++ +Y+ L H+F + +GNV L V+ +M+ LL++K
Sbjct 3028 WLGDIVMCPRHVIASSTT-STIDYDYALSVLRLHNFSISSGNVFLGVVSATMRGALLQIK 3086
Query 3331 VDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF 3390
V+ +N TPKY + ++PG++F++LACY+G+ +GVY MR N+TI+GSF+NG+CGS G+
Sbjct 3087 VNQNNVHTPKYTYRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGY 3146
Query 3391 NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYA 3450
NI+ V FCY+H +EL +G H G+DL+G YG + D+ T Q G + T NVLA+LYA
Sbjct 3147 NINNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTENVLAFLYA 3206
Query 3451 AVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKE 3510
A+ING W+L+ ++ FN A+ + + D L+A+TG+ V + A+++
Sbjct 3207 ALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVG--NTDCFSILAAKTGVDVQRLLASIQS 3264
Query 3511 LLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLI 3570
L +N G+ ILG T L DEFT +VVRQ GV QG + + + + +L+ +
Sbjct 3265 LHKN-FGGKQILGHTSLTDEFTTGEVVRQMYGVNLQGGY--VSRACRNVLLVGSFLT-FF 3320
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMV 3630
+ ++ FF+V P + +++ M +KHK F +FL+P+L + N+
Sbjct 3321 WSELVSYTKFFWVNPGYVTPMFACLSLLSSLLMFTLKHKTLFFQVFLIPALIVTSCINLA 3380
Query 3631 YMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTV--YDDAARRVWTL 3688
+ + + SL G+ + V V+ IL T ++ A V +
Sbjct 3381 FDVEVY--NYLAEHFDYHVSLMGFNAQGLVNIFVCFVVTILHGTYTWRFFNTPASSVTYV 3438
Query 3689 MNVITLVYKVYYGNA-LDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLF 3747
+ ++T Y +Y + L A++++A SVT N V + + + V++ + + P
Sbjct 3439 VALLTAAYNYFYASDILSCAMTLFA---SVTGN--WFVGAVCY--KVAVYMALRF-PTFV 3490
Query 3748 ITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLP 3807
++ +M Y LGY CC++G+ NR+F++++GVYDY VS EF+YM + GL
Sbjct 3491 AIFGDIKSVMFCYLVLGYFTCCFYGILYWFNRFFKVSVGVYDYTVSAAEFKYMVANGLRA 3550
Query 3808 PKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSKLWAQ 3867
P ++D+ L+ KL+GIGG+ IK+++VQSK++D+KC++VVLL L + V ++S WA
Sbjct 3551 PTGTLDSLLLSAKLIGIGGERNIKISSVQSKLTDIKCSNVVLLGCLSSMNVSANSTEWAY 3610
Query 3868 CVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEEMLDNRATLQAIASEFSS 3927
CV LHN I L D +A E +++LL+ LS A ++ L E ++ + LQ++AS +
Sbjct 3611 CVDLHNKINLCNDPEKAQEMLLALLAFFLSKNSAFGLDDLLESYFNDNSMLQSVASTYVG 3670
Query 3928 LPSYAAYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKMADQAMT 3987
LPSY Y A++ YE AV NG ++K+L+ ++NVAKSEFDR+A+ QRKL++MA+QA
Sbjct 3671 LPSYVIYENARQQYEDAVNNGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAAA 3730
Query 3988 QMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLNIIPLTTAAKL 4047
QMYK+AR+ ++++KV SAM ++LF MLR+LD +++ I+N A+DG VPL++IP +A KL
Sbjct 3731 QMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVPLSVIPAVSATKL 3790
Query 4048 MVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIVQLSEINMDNSPNLAWPLIVTA 4107
+V D +Y YA +W I + D D K+V + E+ N+ +L+WPL++
Sbjct 3791 NIVTSDIDSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQNAESLSWPLVLGC 3850
Query 4108 LRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNNSKGGRFVLALLSDHQD 4167
R VKLQNNE+ P L+Q S A A YNN G F+ A +SD D
Sbjct 3851 ER---IVKLQNNEIIPGKLKQRSIKAEGDGIV---GEGKALYNNEGGRTFMYAFISDKPD 3904
Query 4168 LKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATV 4227
L+ ++ G TI ELEPP +F+ D+P G ++KYLYF++ LN L RG VLG + ATV
Sbjct 3905 LRVVKWEFDGGCNTI--ELEPPRKFLVDSPNGAQIKYLYFVRNLNTLRRGAVLGYIGATV 3962
Query 4228 RLQAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITV 4287
RLQAG TE NS++L+ CAFAVDPAK Y D + SG +P+ NCVKML +G GQA+T
Sbjct 3963 RLQAGKQTEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTN 4022
Query 4288 TPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVC 4347
EA+ +Q+S+GGAS CLYCR H++HP+ GFC LKGKYVQ+P DP+ F L N VC
Sbjct 4023 GVEASTNQDSYGGASVCLYCRAHVEHPSMDGFCRLKGKYVQVPLGTV-DPIRFVLENDVC 4081
Query 4348 TVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
VCG W GC+CD+ +MQS D + +LN
Sbjct 4082 KVCGCWLSNGCTCDR---SIMQSTDMA-YLN 4108
Score = 288 bits (737), Expect = 7e-76, Method: Composition-based stats.
Identities = 257/1530 (17%), Positives = 462/1530 (30%), Gaps = 213/1530 (14%)
Query 426 RASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTS 485
R ++ + T + VE N +L+ + E V +N G + + +A S
Sbjct 518 RYTSLVVGSTTKVVSKRVENANVNLV--VVDEDVTLNTTGRTVVVDGLAFF-----ESDG 570
Query 486 AFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVIR 545
+ + +C V + P+ P+ V
Sbjct 571 FYRHLADADVVIEHPVYKSACELKPVFECDPIPD---------FPLPV-AASVAELCVQT 620
Query 546 SIFARTLDAANHSIPDLQRAAVT-ILDGISEQSLRLVDAMVYTSDLLTNSVIIMAYVTGG 604
+ + + + + R I + ++ V+ V DL T ++ +
Sbjct 621 DLLLKNYNTPYKTYSCVVRGDKCCITCTLQFKAPSYVEDAVNFVDLCTKNIGTAGFHEFY 680
Query 605 LVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLK--DAWEILKFLITGVFDI--- 659
+ Q L L T FE + L+ D I + ITG+ +
Sbjct 681 ITAHEQQDLQGFLTTCCTM--SGFECFMPTIPQCPAVLEEIDGGSIWRSFITGLNTMWDF 738
Query 660 ---------VKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFI 710
+ G + + K ++ N L ++ + +AG + I
Sbjct 739 CKRLKVSFGLDGIVVTVARKFKRLGALLAEMYNTYLSTVVENLVLAGVSFKYYATSVPKI 798
Query 711 AQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPV 770
+ Q+ + K FL H V E ELE
Sbjct 799 VLGGCFHSVKSVFASVFQIPVQAGIEKFKVFLN-CVHPVVPRVIETSFV--ELEE----- 850
Query 771 DSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGED- 829
+F A+ G V+G + G F+ KGG +K F ++
Sbjct 851 TTFKPPALNGGIAIVDGFAFYYDGTLYYP---TDGNSVVPICFKKKGGGDVK---FSDEV 904
Query 830 TVWEVQGYKNVRITFELD-ERVDKVLNEKCS------------------VYTVESG-TEV 869
+V + V + FE + E + VLN+ V EV
Sbjct 905 SVKTIDPVYKVSLEFEFESETIMAVLNKAVGNRIKVTGGWDDVVEYINVAIEVLKDHVEV 964
Query 870 TEFACVVAEAVVKTLQPVS--------DLLTNMGIDLDEWSVATFYLFDDAGEENFSSRM 921
++ E PV D ++ +D++ + A D G+E SS
Sbjct 965 PKYYIYDEEGGTDPNLPVMVSQWPLNDDTISQDLLDVEVVTDAPI---DSEGDEVDSS-- 1019
Query 922 YCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDW 981
P + ++E ++ + E +E + L F + ++ D+
Sbjct 1020 ----APEKVADVANSEPGDDGLPVAPETNVESEVEEVAATLSFIKDTPSTVTKDPFAFDF 1075
Query 982 LDDT-------------TEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQ 1028
+ + ++ + ++P + ++ V KC + K
Sbjct 1076 VSYGGLKVLRQSHNNCWVTSTLVQLQLLGIVDDPAMELFSAGRVGPMVR-KCYESQKAIL 1134
Query 1029 SANPMVIVNAANIHLKHG--------GGVAGALNKATNGAMQKES-DDYIKLNGPLTVGG 1079
+ V+A L V G T + + P G
Sbjct 1135 GSLGD--VSACLESLTKDLHTLKITCSVVCG---CGTGERIYEGCAFRMTPTLEPFPYG- 1188
Query 1080 SCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQS 1139
+C L +VG + + +++ PL +A G
Sbjct 1189 ACAQCAQVLMHTFKSIVG--------TGIFCRDTTALSLDSLVVKPLCAAAFIGKDSGHY 1240
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLK---PRVEAPKQEEPPNTEDSKTEEKS 1196
+ + + Y+ + + ++ P V A P K+
Sbjct 1241 VTNFYDAAMA-IDGYGRHQIKYDTLNTICVKDVNWTAPLVPAVDSVVEPVV-KPFYSYKN 1298
Query 1197 VVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLE 1256
V D +K D V K I + ++ ML+ +++
Sbjct 1299 VDFYQGDFSDLVKLPCDFV-VNAANEKLSHG-----GGIAKAIDVYTKGMLQKCSNDYIK 1352
Query 1257 KDAPYMVGDVITSGD----ITCVVIPSKKAGGTTEMLSRALKKVPVDE--YITTYPGQGC 1310
P VG + + VV P +K E+L +A K V + +T G
Sbjct 1353 AHGPIKVGRGVMLEALGLKVFNVVGP-RKGKHAPELLVKAYKSVFANSGVALTPLISVGI 1411
Query 1311 AGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMD 1370
LEE+ +A C + + + E + L + + E P+ D
Sbjct 1412 FSVPLEESLSAFLACVGDRHCKCFCYGDKEREAIIKYMDGLVDAI-FKEALVDTTPVQED 1470
Query 1371 VRAIM-ATIQRKYKGIKIQ----------EGIVDYGVR--FFFYTSKEPVASIITKLNSL 1417
V+ + + ++ +I+ EG++ G F S S+ LN +
Sbjct 1471 VQQVSQKPVLPNFEPFRIEGAHAFYECNPEGLMSLGADKLVLFTNSNLDFCSVGKCLNDV 1530
Query 1418 NEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHF 1477
+ I A C+ +S V ++G K
Sbjct 1531 TSGALLEAINVFKKSNKTVPAGNCV---TLDCANMISITMVVLPFDGDANY-DKNYARAV 1586
Query 1478 VETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLL 1537
V+ L G + L V+ K+ + ++ V D E
Sbjct 1587 VKVSKLKG----------KLVLAVDDATLYSKLSHLSVLGFVSTPDDVE----------- 1625
Query 1538 SLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFV 1597
K++ + T D ++ V+ + TYGQQ GP ++ VT KP V V
Sbjct 1626 RFYANKSVVIKVTEDTRSVKAVKVESTATYGQQIGPCLVNDTVVTDNKPVVADV--VAKV 1683
Query 1598 LPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTK-KWKFPQVGGLTSIKWADNNCYLSSV 1656
+P+ + F+ L+HT + V G IK DNNC+++
Sbjct 1684 VPNANWDSHYGFDKAGEF---------HMLDHTGFTFPSEVVNGRRVIKTTDNNCWVNVT 1734
Query 1657 LLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQH- 1715
L LQ +F + LQ + GD A F + + G+ D + L ++
Sbjct 1735 CLQLQFARFRFKSAGLQAMWESYCTGDVAMFVHWLYWLTGVDKGQPSDSENALNMLSKYI 1794
Query 1716 --ANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIP-CVCGRDATQ 1772
A + +RV + C C ++ T V A + LK GV C G +
Sbjct 1795 VPAGSVTIERVTHDGC-CCSKRVVTAPVVNASV---------LKLGVEDGLCPHGLNYIG 1844
Query 1773 YLVQQESSFVMMSAPPAEYKLQQGTFLCANEYT-----GNYQCGHYTHITAKETLYRIDG 1827
+V + + +++ FL YT GN GHYT + DG
Sbjct 1845 KVVVVKGTTIVV-NVGKPVVAPSHLFLKGVSYTTFLDNGNGVVGHYTVFDHGTGMVH-DG 1902
Query 1828 AHLTKMSEYKGPVTDVFYKETSYTTTIKPV 1857
PVT+V E + PV
Sbjct 1903 DAFVPGDLNVSPVTNVVVSEQTAVVIKDPV 1932
Score = 63.6 bits (153), Expect = 7e-08, Method: Composition-based stats.
Identities = 49/260 (19%), Positives = 83/260 (32%), Gaps = 29/260 (11%)
Query 1632 KWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI 1691
+ F GGL ++ + NNC+++S L+ LQ L + + A AG
Sbjct 1072 AFDFVSYGGLKVLRQSHNNCWVTSTLVQLQLLGIVDDP-----AMELFSAGRVGPMVRKC 1126
Query 1692 LAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTL 1751
+G LGDV + L + +L + K +VVC CG G + T
Sbjct 1127 YESQKAILGSLGDVSACLESLTK--DLHTLKITCSVVCG-CGTGERIYEG---CAFRMTP 1180
Query 1752 SYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPA-EYKLQQGTFLCANEYTGNYQC 1810
+ + C + + + A LCA + G
Sbjct 1181 TLEPF--PYGACAQCAQVLMHTFKSIVGTGIFCRDTTALSLDSLVVKPLCAAAFIGK-DS 1237
Query 1811 GHYT--HITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTE 1868
GHY A + + + V DV + P+ +D V
Sbjct 1238 GHYVTNFYDAAMAIDGYGRHQIKYDTLNTICVKDVNWTA--------PLVPAVDSVVEPV 1289
Query 1869 IEPKLDGYYKKDNAYYTEQP 1888
++P +Y N + +
Sbjct 1290 VKP----FYSYKNVDFYQGD 1305
Score = 61.7 bits (148), Expect = 2e-07, Method: Composition-based stats.
Identities = 49/212 (23%), Positives = 72/212 (34%), Gaps = 43/212 (20%)
Query 172 ELTRELNGGAVTRYVDNNFCGPDGYPLD-----CIKDFLARAGKSMCTLSEQLDYIESKR 226
ELT GG + VD CG DG P+ DF A +S+
Sbjct 102 ELTFGRRGGNIVP-VDQYMCGADGKPVLQESEWEYTDFFA----------------DSED 144
Query 227 GVYCCRDHEHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVI-Q 285
G + AW ERSD SY Q IKS T++ F + +KV
Sbjct 145 GQLNIAGITYVKAWIVERSDVSYASQNLTSIKSITYCSTYE-----HTFLDGTAMKVART 199
Query 286 PRVEKKKTEGFMGRIRSVYPVASPQECNN-----------MHLSTLMKCNHCDEVSWQTC 334
P+++K + ++Y +N + L +KC C W
Sbjct 200 PKIKKNVV--LSEPLATIYREIGSPFVDNGSDARSIIRRPVFLHAFVKCK-CGSYHWTVG 256
Query 335 DFLKATCEHCGTENLVIEGPTTCGYLPTNAVV 366
D+ CG + +C +P + VV
Sbjct 257 DWTSYVSTCCGFK-CKPVLVASCSAMPGSVVV 287
>sp|P0C6V4|R1A_IBVBC Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain Beaudette CK) OX=160235 GN=1a PE=3
SV=1
Length=3951
Score = 2563 bits (6642), Expect = 0.0, Method: Composition-based stats.
Identities = 861/2960 (29%), Positives = 1344/2960 (45%), Gaps = 309/2960 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG Y V + E K +P+ D
Sbjct 1176 KQKTIYLTEDGVKYRSIVLKPGDSLG-QFGQVYAKNKIVFTA---DDVEDKEILYVPTTD 1231
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1232 KSILE----YYGLDAQKYVIYLQTL--AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQA 1285
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A VG+ D + +L +H + +
Sbjct 1286 AKIRFKG-FLTEAWAKLLGGDPTDFVAWCYASCTAKVGDFSDANWLLANLAEHFDADYTN 1344
Query 1723 RVLNV-VCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
L V +CG K+ L G+EA + + + + KT S CG + T +++
Sbjct 1345 AFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLP 1404
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT D + K
Sbjct 1405 YLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAG----QAFDNLAKDRKFGKKS 1460
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y ++ K ++ +
Sbjct 1461 PYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNL------------------ATSS 1502
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFDN D Q + L V PD ++ Y +
Sbjct 1503 KASFDNL----------TDFEQW--YDSNIYESLKVQESPD--------NFDKYVSF--- 1539
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1540 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTD------E 1578
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE 2078
S+ P V++ + +K V GN ++ L E
Sbjct 1579 NSKAPVYYPVLDAIS---------LKAIWVEGNANFVVGHPNY-YSKSLHIPTFW----E 1624
Query 2079 NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNC----- 2133
N +K +++ T+ +N +I K + +++ T+ C
Sbjct 1625 NAENFVKMGDKIGGV----TMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIG 1680
Query 2134 --AKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAG 2191
A +A +V + + + LC T+ R + + K + +
Sbjct 1681 KAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSV 1740
Query 2192 INYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
+ K+ + A L++ + + + T + G S C ++ +S
Sbjct 1741 VASYKTVLCKVVL--ATLLIVWFVYTSNPVMFTGIRVLDFLFEG--SLCGPYKDYGKDSF 1796
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLF 2311
+V + +C F C +CL DSL Y +++ YK + G W Y++F
Sbjct 1797 DV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVF 1849
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIF 2363
F V Y + + NS +L WF V + + F
Sbjct 1850 LILFVKPVAGF---VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNF 1897
Query 2364 FASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1898 MGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSG 1957
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + +
Sbjct 1958 YNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFV 2017
Query 2479 HLYFD-KAGQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------ 2530
+L + K + F D L +A K +L I DG C+ +
Sbjct 2018 NLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEE 2077
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+K+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV
Sbjct 2078 AKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD-------- 2128
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNF 2650
TA G D +LS ++ ++ H+ D++ TGD N
Sbjct 2129 -TAALNYKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTY-NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + ++W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K+ + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELR 2926
+ YT +I F TS + +A C ++ A P YC++ N G++ + +
Sbjct 2409 RE-IVGYTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSII 2466
Query 2927 PDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNE 2986
P Y +G + P L + VV YCR CE + G C+S + +WVL N+
Sbjct 2467 PHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFND 2525
Query 2987 HYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR 3046
Y + GVFCG L+ ++ + V ++ + +I ++V +KF+
Sbjct 2526 EYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQG 2584
Query 3047 VFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWF 3106
VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2585 VFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLV 2644
Query 3107 AMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLL 3162
F IVP W+ Y+ I + W + R +++G F ++ AA TF++
Sbjct 2645 FTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVI 2704
Query 3163 NKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSG 3222
++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG
Sbjct 2705 RGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSG 2761
Query 3223 ADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV 3282
+++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPRHV
Sbjct 2762 VEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHV 2821
Query 3283 ICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
+ + D+L +NH F V + V L V+ ++ +L L+ +N +TPKY
Sbjct 2822 L---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKY 2878
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY 3401
KF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F Y
Sbjct 2879 KFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFY 2938
Query 3402 MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRW--- 3458
MHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2939 MHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFS 2998
Query 3459 ---FLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNG 3515
+L T +++D+N A + P + + LSA TG+ V + + + +
Sbjct 2999 LPKWLESTTVSVDDYNKWAGDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKNSQ 3055
Query 3516 MNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLI 3570
G ILG EDE TP V Q GV Q F V+ W L FL L
Sbjct 3056 WGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCA 3112
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------- 3623
+V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3113 IVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCA 3166
Query 3624 -------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLL 3669
V + + Y P + ++ W+ L + ++ ++ C M + LL
Sbjct 3167 EVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLL 3225
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
+L + ++T N +T + GN W L + +
Sbjct 3226 MLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLANVSSN 3270
Query 3730 FLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F LTLG
Sbjct 3271 SLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVFGLTLG 3329
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SDVKCT+
Sbjct 3330 KYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTT 3389
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINR 3906
VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L + +D++
Sbjct 3390 VVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSE 3449
Query 3907 LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLN 3962
C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L +K+ N
Sbjct 3450 YCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAAN 3509
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ L
Sbjct 3510 IAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKL 3569
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V+DAD
Sbjct 3570 NVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDAD 3629
Query 4083 SKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAG 4134
+ + + N+AWPL V R V LQNNEL P ++ +C AG
Sbjct 3630 GTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAG 3689
Query 4135 TTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVT 4194
Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3690 VDQAHCSVES-KCYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGM 3747
Query 4195 DTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDP 4253
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDP
Sbjct 3748 KVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDP 3807
Query 4254 AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH 4313
A Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI H
Sbjct 3808 ADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAH 3867
Query 4314 P----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP--- 4366
P N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P
Sbjct 3868 PGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSS 3926
Query 4367 LMQSADAS----TFLNGFAV 4382
+ A AS +LNG+ V
Sbjct 3927 VQSVAGASDFDKNYLNGYGV 3946
Score = 173 bits (438), Expect = 4e-41, Method: Composition-based stats.
Identities = 74/354 (21%), Positives = 132/354 (37%), Gaps = 46/354 (13%)
Query 879 AVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAEC 938
AV Q V D+L + G +D A L ++ + + +
Sbjct 872 AVKPLPQKVVDVLGDWGEAVD----AQEQLCQQEPLQHTFEEPVENSTGSSKTMTEQVVV 927
Query 939 EEEEIDE-------------TCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDT 985
E++E+ E T ++ L F E V +++ + +
Sbjct 928 EDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEEVVSQKDGAQ-IKQEP 986
Query 986 TEQSEIEPEPE--------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVN 1037
+ + + E + T E+P +F Y ++ + I K IVN
Sbjct 987 IQVVKPQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLTVV---IAKALDEFKEFCIVN 1041
Query 1038 AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL-HVV 1096
AAN H+ HG GVA A+ + +DY+K +GP + +C+ +VV
Sbjct 1042 AANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---RLVTPSFVKGIQCVNNVV 1098
Query 1097 GPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIA 1154
GP + L AAY+N ++ + P+LS GIFG ++ + +R +
Sbjct 1099 GPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD----FKMSIDAMRE-AFEG 1153
Query 1155 VNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ L + +++D KQ+ TED + +S+V KP D +
Sbjct 1154 CTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSIVLKPGDSLGQF 1203
Score = 40.9 bits (94), Expect = 0.40, Method: Composition-based stats.
Identities = 40/255 (16%), Positives = 86/255 (34%), Gaps = 28/255 (11%)
Query 635 LSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVT 694
+ V+F W+ + IV V + C + +D ++ + +
Sbjct 512 FTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYK------S 565
Query 695 IAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSE 754
L ++ + G+++ G E + +++ ++ S D + +
Sbjct 566 FKKCALGRIHGD--LLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDD 623
Query 755 EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFR 814
+ +N ++ D + KD+ Y L A N V +
Sbjct 624 VTLPENQPGHMVQIEDDGKNY------------MFFRFKKDENIYYTPMSQLGAINVVCK 671
Query 815 LKGGAPIKGVTFGEDTVWEV--QGYKNVRITFELD-ERVDKVLNEKCSV-YTVESGTEVT 870
G K VTFGE TV E+ ++++ E E + + + V++ V
Sbjct 672 AGG----KTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVE 727
Query 871 EFACVVAEAVVKTLQ 885
+ V+ E + L+
Sbjct 728 QLLSVIYEKMCDDLK 742
>sp|P0C6V3|R1A_IBVB Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain Beaudette) OX=11122 GN=1a PE=1 SV=1
Length=3951
Score = 2563 bits (6642), Expect = 0.0, Method: Composition-based stats.
Identities = 861/2960 (29%), Positives = 1344/2960 (45%), Gaps = 309/2960 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG Y V + E K +P+ D
Sbjct 1176 KQKTIYLTEDGVKYRSIVLKPGDSLG-QFGQVYAKNKIVFTA---DDVEDKEILYVPTTD 1231
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1232 KSILE----YYGLDAQKYVIYLQTL--AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQA 1285
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A VG+ D + +L +H + +
Sbjct 1286 AKIRFKG-FLTEAWAKLLGGDPTDFVAWCYASCTAKVGDFSDANWLLANLAEHFDADYTN 1344
Query 1723 RVLNV-VCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
L V +CG K+ L G+EA + + + + KT S CG + T +++
Sbjct 1345 AFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLP 1404
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT D + K
Sbjct 1405 YLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAG----QAFDNLAKDRKFGKKS 1460
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y ++ K ++ +
Sbjct 1461 PYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNL------------------ATSS 1502
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFDN D Q + L V PD ++ Y +
Sbjct 1503 KASFDNL----------TDFEQW--YDSNIYESLKVQESPD--------NFDKYVSF--- 1539
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1540 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTD------E 1578
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE 2078
S+ P V++ + +K V GN ++ L E
Sbjct 1579 NSKAPVYYPVLDAIS---------LKAIWVEGNANFVVGHPNY-YSKSLHIPTFW----E 1624
Query 2079 NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNC----- 2133
N +K +++ T+ +N +I K + +++ T+ C
Sbjct 1625 NAENFVKMGDKIGGV----TMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIG 1680
Query 2134 --AKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAG 2191
A +A +V + + + LC T+ R + + K + +
Sbjct 1681 KAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSV 1740
Query 2192 INYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
+ K+ + A L++ + + + T + G S C ++ +S
Sbjct 1741 VASYKTVLCKVVL--ATLLIVWFVYTSNPVMFTGIRVLDFLFEG--SLCGPYKDYGKDSF 1796
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLF 2311
+V + +C F C +CL DSL Y +++ YK + G W Y++F
Sbjct 1797 DV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVF 1849
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIF 2363
F V Y + + NS +L WF V + + F
Sbjct 1850 LILFVKPVAGF---VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNF 1897
Query 2364 FASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1898 MGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSG 1957
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + +
Sbjct 1958 YNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFV 2017
Query 2479 HLYFD-KAGQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------ 2530
+L + K + F D L +A K +L I DG C+ +
Sbjct 2018 NLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEE 2077
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+K+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV
Sbjct 2078 AKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD-------- 2128
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNF 2650
TA G D +LS ++ ++ H+ D++ TGD N
Sbjct 2129 -TAALNYKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTY-NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + ++W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K+ + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELR 2926
+ YT +I F TS + +A C ++ A P YC++ N G++ + +
Sbjct 2409 RE-IVGYTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSII 2466
Query 2927 PDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNE 2986
P Y +G + P L + VV YCR CE + G C+S + +WVL N+
Sbjct 2467 PHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFND 2525
Query 2987 HYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR 3046
Y + GVFCG L+ ++ + V ++ + +I ++V +KF+
Sbjct 2526 EYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQG 2584
Query 3047 VFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWF 3106
VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2585 VFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLV 2644
Query 3107 AMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLL 3162
F IVP W+ Y+ I + W + R +++G F ++ AA TF++
Sbjct 2645 FTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVI 2704
Query 3163 NKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSG 3222
++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG
Sbjct 2705 RGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSG 2761
Query 3223 ADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV 3282
+++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPRHV
Sbjct 2762 VEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHV 2821
Query 3283 ICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
+ + D+L +NH F V + V L V+ ++ +L L+ +N +TPKY
Sbjct 2822 L---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKY 2878
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY 3401
KF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F Y
Sbjct 2879 KFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFY 2938
Query 3402 MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRW--- 3458
MHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2939 MHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFS 2998
Query 3459 ---FLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNG 3515
+L T +++D+N A + P + + LSA TG+ V + + + +
Sbjct 2999 LPKWLESTTVSVDDYNKWAGDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKNSQ 3055
Query 3516 MNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLI 3570
G ILG EDE TP V Q GV Q F V+ W L FL L
Sbjct 3056 WGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCA 3112
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------- 3623
+V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3113 IVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCA 3166
Query 3624 -------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLL 3669
V + + Y P + ++ W+ L + ++ ++ C M + LL
Sbjct 3167 EVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLL 3225
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
+L + ++T N +T + GN W L + +
Sbjct 3226 MLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLANVSSN 3270
Query 3730 FLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F LTLG
Sbjct 3271 SLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVFGLTLG 3329
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SDVKCT+
Sbjct 3330 KYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTT 3389
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINR 3906
VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L + +D++
Sbjct 3390 VVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSE 3449
Query 3907 LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLN 3962
C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L +K+ N
Sbjct 3450 YCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAAN 3509
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ L
Sbjct 3510 IAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKL 3569
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V+DAD
Sbjct 3570 NVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDAD 3629
Query 4083 SKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAG 4134
+ + + N+AWPL V R V LQNNEL P ++ +C AG
Sbjct 3630 GTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAG 3689
Query 4135 TTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVT 4194
Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3690 VDQAHCSVES-KCYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGM 3747
Query 4195 DTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDP 4253
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDP
Sbjct 3748 KVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDP 3807
Query 4254 AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH 4313
A Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI H
Sbjct 3808 ADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAH 3867
Query 4314 P----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP--- 4366
P N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P
Sbjct 3868 PGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSS 3926
Query 4367 LMQSADAS----TFLNGFAV 4382
+ A AS +LNG+ V
Sbjct 3927 VQSVAGASDFDKNYLNGYGV 3946
Score = 173 bits (438), Expect = 4e-41, Method: Composition-based stats.
Identities = 74/354 (21%), Positives = 132/354 (37%), Gaps = 46/354 (13%)
Query 879 AVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAEC 938
AV Q V D+L + G +D A L ++ + + +
Sbjct 872 AVKPLPQKVVDVLGDWGEAVD----AQEQLCQQEPLQHTFEEPVENSTGSSKTMTEQVVV 927
Query 939 EEEEIDE-------------TCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDT 985
E++E+ E T ++ L F E V +++ + +
Sbjct 928 EDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEEVVSQKDGAQ-IKQEP 986
Query 986 TEQSEIEPEPE--------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVN 1037
+ + + E + T E+P +F Y ++ + I K IVN
Sbjct 987 IQVVKPQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLTVV---IAKALDEFKEFCIVN 1041
Query 1038 AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL-HVV 1096
AAN H+ HG GVA A+ + +DY+K +GP + +C+ +VV
Sbjct 1042 AANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---RLVTPSFVKGIQCVNNVV 1098
Query 1097 GPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIA 1154
GP + L AAY+N ++ + P+LS GIFG ++ + +R +
Sbjct 1099 GPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD----FKMSIDAMRE-AFEG 1153
Query 1155 VNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ L + +++D KQ+ TED + +S+V KP D +
Sbjct 1154 CTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSIVLKPGDSLGQF 1203
Score = 40.9 bits (94), Expect = 0.40, Method: Composition-based stats.
Identities = 40/255 (16%), Positives = 86/255 (34%), Gaps = 28/255 (11%)
Query 635 LSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVT 694
+ V+F W+ + IV V + C + +D ++ + +
Sbjct 512 FTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYK------S 565
Query 695 IAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSE 754
L ++ + G+++ G E + +++ ++ S D + +
Sbjct 566 FKKCALGRIHGD--LLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDD 623
Query 755 EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFR 814
+ +N ++ D + KD+ Y L A N V +
Sbjct 624 VTLPENQPGHMVQIEDDGKNY------------MFFRFKKDENIYYTPMSQLGAINVVCK 671
Query 815 LKGGAPIKGVTFGEDTVWEV--QGYKNVRITFELD-ERVDKVLNEKCSV-YTVESGTEVT 870
G K VTFGE TV E+ ++++ E E + + + V++ V
Sbjct 672 AGG----KTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVE 727
Query 871 EFACVVAEAVVKTLQ 885
+ V+ E + L+
Sbjct 728 QLLSVIYEKMCDDLK 742
>sp|P0C6V5|R1A_IBVM Replicase polyprotein 1a OS=Avian infectious
bronchitis virus (strain M41) OX=11127 GN=1a PE=1 SV=1
Length=3953
Score = 2562 bits (6641), Expect = 0.0, Method: Composition-based stats.
Identities = 858/2956 (29%), Positives = 1348/2956 (46%), Gaps = 301/2956 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG + V + E K +P+ D
Sbjct 1178 KQKTIYLTEDGVKYRSVVLKPGDSLG-QFGQVFARNKVVFSA---DDVEDKEILFIPTTD 1233
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1234 KTILE----YYGLDAQKYVTYLQTL--AQKWDVQYRDNFVILEWRDGNCWISSAIVLLQA 1287
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A N VG+ D + +L +H + +
Sbjct 1288 AKIRFKG-FLAEAWAKLLGGDPTDFVAWCYASCNAKVGDFSDANWLLANLAEHFDADYTN 1346
Query 1723 RVL-NVVCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
+L V +CG K+ L G+EA + + + + KT S CG +T +++
Sbjct 1347 ALLKKCVSCNCGVKSYELRGLEACIQPVRAPNLLHFKTQYSNCPTCGASSTDEVIEASLP 1406
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT K D + K
Sbjct 1407 YLLLFATDGPATVDCDENAVGTVVFIGSTNSGHCYTQADGK----AFDNLAKDRKFGRKS 1462
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y S + + + ++ +
Sbjct 1463 PYITAMYTRFSLRSENPLLVVEHSKGKAKVVKEDVSNL------------------ATSS 1504
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFD+ D Q + L V PD + Y +
Sbjct 1505 KASFDDL----------TDFEQW--YDSNIYESLKVQETPD--------NLDEYVSF--- 1541
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1542 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFTYKLTPDTD------E 1580
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAY-V 2077
S+ P V+++ +++ +E VVG+ + E + Y +
Sbjct 1581 NSKTPVYYPVLDSISLRAIWVEGSAN--FVVGHPNYYSKSLRIPTFWENAESFVKMGYKI 1638
Query 2078 ENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRL 2137
+ ++ + + L+ + A ++ S ++ Q A +
Sbjct 1639 DGVTMGLWRAEHLNK----PNLERIFNIAKKAIVGSSVVT------TQCGKILVKAATYV 1688
Query 2138 AQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKS 2197
A +V + + + + LC FT+ + + K V + + V S
Sbjct 1689 ADKVGDGVVRNITDRIKGLCGFTRGHFEK---KMSLQFLKTLVFFFFYFLKASSKSLVSS 1745
Query 2198 PKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMD 2257
K + LL++ S V VL S C + +S +V +
Sbjct 1746 YKIVLCKVVFATLLIVWFIYTSNPVVFTGIRVL-DFLFEGSLCGPYNDYGKDSFDV--LR 1802
Query 2258 FCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYL 2317
+C G F C +CL DSL Y +++ YK + G+ W Y++F F
Sbjct 1803 YCAGDFTCRVCLHDRDSLHLYKHAYSVE---QIYKDAAS--GINFNWNWLYLVFLILFVK 1857
Query 2318 LGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIFFASFYY 2369
V Y + + +S +L WF V + + F + +Y
Sbjct 1858 PVAGF---VIICYCVKYLVLSSTVLQTGVGFLDWF---------VKTVFTHFNFMGAGFY 1905
Query 2370 IWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKT 2424
W Y VH + C TC +C + R+ R E + +V G K+ +VY N G FCK
Sbjct 1906 FWLFYKIYVQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYNFCKR 1965
Query 2425 HNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDK 2484
HNW C NCD + +TF+S EVA +LS + KR + PT + ++V V + ++L +
Sbjct 1966 HNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVYEACVVDDFVNLKYKA 2025
Query 2485 A-GQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------SKSASV 2536
A K + F D L +A K +L I DG C+ + +K+A+V
Sbjct 2026 AIPGKDNASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAKNAAV 2085
Query 2537 YYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSE 2596
YY+Q +C+PIL+LDQAL + VS + D S SV TA
Sbjct 2086 YYAQYLCKPILILDQALYEQL-IVEPVSKSVIDKVCSILSNIISVD---------TAALN 2135
Query 2597 LAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYN- 2655
G D +LS ++ ++ H+ ++E TGD N + +Y
Sbjct 2136 YKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHEVEYTGDGFTNVIPSYGM 2182
Query 2656 KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNI 2715
+ +TPRD G I+ +A N +V + ++W D + LS+ K + SA K+
Sbjct 2183 DTDKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSDLIKLSDSCLKYLISATVKSGG 2240
Query 2716 PFRLTCATTRQVVNVITTKISL--KGGKIVSTCFKLM---LKATLLCVLAALVC---YIV 2767
F +T + +QV++ T K+ + K G +++ FK K + + C Y
Sbjct 2241 RFFITKSGAKQVISCHTQKLLVEKKAGGVINNTFKWFMSCFKWLFVFYILFTACCLGYYY 2300
Query 2768 MPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYK 2823
M ++ +H Y T + G+K I GV R+I+S D+CF+NK FDA++ G SY+
Sbjct 2301 MEMNKSFVHPMYDVNSTLHVEGFKVIDKGVIREIVSEDNCFSNKFVNFDAFW---GKSYE 2357
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFSAVGNIC 2873
N+K+CP+V +I + G + G+PG V ++G F+H ++P F+ +
Sbjct 2358 NNKNCPIVTVVIDGD-GTVAVGVPGFVSWVMDGVMFVHMTQTDRRPWYIPTWFNRE-IVG 2415
Query 2874 YTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYV 2932
YT +I F TS + +A C ++ A P YC++ N G++ + + P Y
Sbjct 2416 YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYF 2474
Query 2933 LMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALS 2992
+G + P L + +V YCR CE ++ G C+S +WVL N+ Y +
Sbjct 2475 QPNGVRLIVPQQILH-TPYIVKFVSDSYCRGSVCEYTKPGYCVSLDSQWVLFNDEYISKP 2533
Query 2993 GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYN 3052
GVFCG L+ N+ + V ++ + +I +++ +KF+ VF Y
Sbjct 2534 GVFCGSTVRELMFNMVSTFFTGVNP-NIYIQLATMFLILVVIVLIFAMVIKFQGVFKAYA 2592
Query 3053 HVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPI 3112
+V L+++++ +LC+ S L + V Y Y + + + + + H F I
Sbjct 2593 TIVFTIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASMVTSRNTAIIMHCWLVFTFGLI 2652
Query 3113 VPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYL 3168
VP W+ Y+ I + W + R +++G F ++ AA TF++ ++
Sbjct 2653 VPTWLACCYLGFILYMYTPLVFWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGTEFV 2712
Query 3169 KLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQ 3228
KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG +V+Y
Sbjct 2713 KLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEVVYT 2769
Query 3229 PPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAED 3288
PP+ SI + LQ+GF+K+ PS VE C+V V+ LNGLWL D++YCPRHV+
Sbjct 2770 PPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVL---GK 2826
Query 3289 MLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQ 3347
+ D+L +NH F V N V L V+ ++ +L L+ +N +TPKYKFV+
Sbjct 2827 FSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAVANAETPKYKFVKAN 2886
Query 3348 PGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMEL 3407
G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F YMHH+EL
Sbjct 2887 CGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLEL 2946
Query 3408 PTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVI-------NGDRWFL 3460
P +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I + +W L
Sbjct 2947 PNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQPKW-L 3005
Query 3461 NRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT 3520
T ++ D+N A + P + + LSA TG+ V + + +
Sbjct 3006 ESTTVSIEDYNRWASDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKSAQWGSDP 3062
Query 3521 ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLILVQST 3575
ILG EDE TP V Q GV Q F V+ W L FL L +V T
Sbjct 3063 ILGQYNFEDELTPESVFNQVGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCAIVLFT 3119
Query 3576 QWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------------ 3623
L F+V+ L +MA+ + VKH A++ FLLP+L T
Sbjct 3120 AVPLKFYVHAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCAEVPFI 3173
Query 3624 --------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLLILMTA 3674
V + + Y P + ++ W+ L + ++ ++ C M + LL+L
Sbjct 3174 YNTLISQVVIFLSQWYDPVVF-DTMVPWMLLPLVLYTAFKCVQGCYMNSFNTSLLMLYQ- 3231
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
+ ++T N +T + GN W L + + L
Sbjct 3232 ---FMKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTIVLANVSSNSLIGL 3277
Query 3735 IVFVCVE----YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
IVF C + Y + L +M+ +G+ C CYFGL+ +N+ F LTLG Y++
Sbjct 3278 IVFKCAKWMLYYCNATYFNNYVLMAVMV--NGIGWLCTCYFGLYWWVNKVFGLTLGKYNF 3335
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
VS ++RYM + PPK+ + F NI + GIGG + +ATVQSK+SDVKCT+VVL+
Sbjct 3336 KVSVDQYRYMCLHKVNPPKTVWEVFTTNILIQGIGGDRVLPIATVQSKLSDVKCTTVVLM 3395
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
+L +L VE++SK+ A V+LHN IL + D E + ++ +L L + +D+ C++
Sbjct 3396 QLLTKLNVEANSKMHAYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLGEYCDD 3455
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLNVAKS 3966
+L LQ++ EFS +PSYA Y A+ YE+ +A+ G ++ L +K+ N+AKS
Sbjct 3456 ILKRSTVLQSVTQEFSHIPSYAEYERAKSIYEKVLADSKNGGVTQQELAAYRKAANIAKS 3515
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ LN +
Sbjct 3516 VFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLF 3575
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+ A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V DAD +
Sbjct 3576 DQANSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDCVTDADGTEL 3635
Query 4087 QLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAGTTQT 4138
+ + N+AWPL V R V LQNNEL P ++ +C AG Q
Sbjct 3636 HPTSTGSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELMPHGVKTKACVAGVDQA 3695
Query 4139 ACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPK 4198
C+ ++ YY + G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3696 HCSVES-KCYYTSISGSSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGMKVGD 3753
Query 4199 GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDPAKAY 4257
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDPA Y
Sbjct 3754 KVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTY 3813
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP--- 4314
Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI HP
Sbjct 3814 CKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGGA 3873
Query 4315 -NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP------- 4366
N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P
Sbjct 3874 GNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKPSVQSV 3932
Query 4367 LMQSADASTFLNGFAV 4382
+ S +LNG+ V
Sbjct 3933 AVASGFDKNYLNGYGV 3948
Score = 218 bits (555), Expect = 8e-55, Method: Composition-based stats.
Identities = 84/358 (23%), Positives = 137/358 (38%), Gaps = 49/358 (14%)
Query 878 EAVVKTL-QPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
E VK L Q V D+L + G +D A L S + F + + A
Sbjct 870 EGAVKALPQKVIDVLGDWGEAVD----AQEQLCQQESTRVISEKSVEGFTGSCDAMAEQA 925
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEE-------EEEDWLDDTTEQS 989
EE+EI E ++D P + ET +E +E+ + E+
Sbjct 926 IVEEQEIVPVVEQ---SQDVVVFTPADLEVVKETAEEVDEFILISAVPKEEVVSQEKEEP 982
Query 990 EIEPEPEPTPEEPVN----------------QFTGYLKLTDNVAIKCVDIVKEAQSANPM 1033
++E EP + +F Y ++A+ I K
Sbjct 983 QVEQEPTLVVKAQREKKAKKFKVKPATCEKPKFLEYKTCVGDLAVV---IAKALDEFKEF 1039
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL 1093
IVNAAN H+ HGGGVA A+ + DY+K +GP + +C+
Sbjct 1040 CIVNAANEHMSHGGGVAKAIADFCGPDFVEYCADYVKKHGPQQ---KLVTPSFVKGIQCV 1096
Query 1094 -HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQ 1150
+VVGP + L AAY++ ++ + P+LS+GIFG ++ + +R
Sbjct 1097 NNVVGPRHGDSNLREKLVAAYKSVLVGGVVNYVVPVLSSGIFGVD----FKISIDAMRE- 1151
Query 1151 VYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ + L + +++D KQ+ TED + +SVV KP D +
Sbjct 1152 AFKGCAIRVLLFSLSQEHIDYFDATC---KQKTIYLTEDG-VKYRSVVLKPGDSLGQF 1205
Score = 38.9 bits (89), Expect = 1.7, Method: Composition-based stats.
Identities = 27/104 (26%), Positives = 42/104 (40%), Gaps = 8/104 (8%)
Query 786 NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEV--QGYKNVRIT 843
N + KD+ Y L A N V + G K VTFGE TV E+ ++++
Sbjct 643 NYMFFRFKKDENIYYTPMSQLGAINVVCKAGG----KTVTFGETTVQEIPPPDVVFIKVS 698
Query 844 FELD-ERVDKVLNEKCSV-YTVESGTEVTEFACVVAEAVVKTLQ 885
E E + + + VE+ V + VV E + L+
Sbjct 699 IECCGEPWNTIFKKAYKEPIEVETDLTVEQLLSVVYEKMCDDLK 742
>sp|P0C6Y3|R1AB_IBVM Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain M41) OX=11127 GN=rep PE=1 SV=1
Length=6631
Score = 2556 bits (6626), Expect = 0.0, Method: Composition-based stats.
Identities = 857/2946 (29%), Positives = 1345/2946 (46%), Gaps = 297/2946 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG + V + E K +P+ D
Sbjct 1178 KQKTIYLTEDGVKYRSVVLKPGDSLG-QFGQVFARNKVVFSA---DDVEDKEILFIPTTD 1233
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1234 KTILE----YYGLDAQKYVTYLQTL--AQKWDVQYRDNFVILEWRDGNCWISSAIVLLQA 1287
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A N VG+ D + +L +H + +
Sbjct 1288 AKIRFKG-FLAEAWAKLLGGDPTDFVAWCYASCNAKVGDFSDANWLLANLAEHFDADYTN 1346
Query 1723 RVL-NVVCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
+L V +CG K+ L G+EA + + + + KT S CG +T +++
Sbjct 1347 ALLKKCVSCNCGVKSYELRGLEACIQPVRAPNLLHFKTQYSNCPTCGASSTDEVIEASLP 1406
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT K D + K
Sbjct 1407 YLLLFATDGPATVDCDENAVGTVVFIGSTNSGHCYTQADGK----AFDNLAKDRKFGRKS 1462
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y S + + + ++ +
Sbjct 1463 PYITAMYTRFSLRSENPLLVVEHSKGKAKVVKEDVSNL------------------ATSS 1504
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFD+ D Q + L V PD + Y +
Sbjct 1505 KASFDDL----------TDFEQW--YDSNIYESLKVQETPD--------NLDEYVSF--- 1541
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1542 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFTYKLTPDTD------E 1580
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAY-V 2077
S+ P V+++ +++ +E VVG+ + E + Y +
Sbjct 1581 NSKTPVYYPVLDSISLRAIWVEGSAN--FVVGHPNYYSKSLRIPTFWENAESFVKMGYKI 1638
Query 2078 ENTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRL 2137
+ ++ + + L+ + A ++ S ++ Q A +
Sbjct 1639 DGVTMGLWRAEHLNK----PNLERIFNIAKKAIVGSSVVT------TQCGKILVKAATYV 1688
Query 2138 AQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKS 2197
A +V + + + + LC FT+ + + K V + + V S
Sbjct 1689 ADKVGDGVVRNITDRIKGLCGFTRGHFEK---KMSLQFLKTLVFFFFYFLKASSKSLVSS 1745
Query 2198 PKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMD 2257
K + LL++ S V VL S C + +S +V +
Sbjct 1746 YKIVLCKVVFATLLIVWFIYTSNPVVFTGIRVL-DFLFEGSLCGPYNDYGKDSFDV--LR 1802
Query 2258 FCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYL 2317
+C G F C +CL DSL Y +++ YK + G+ W Y++F F
Sbjct 1803 YCAGDFTCRVCLHDRDSLHLYKHAYSVE---QIYKDAAS--GINFNWNWLYLVFLILFVK 1857
Query 2318 LGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIFFASFYY 2369
V Y + + +S +L WF V + + F + +Y
Sbjct 1858 PVAGF---VIICYCVKYLVLSSTVLQTGVGFLDWF---------VKTVFTHFNFMGAGFY 1905
Query 2370 IWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKT 2424
W Y VH + C TC +C + R+ R E + +V G K+ +VY N G FCK
Sbjct 1906 FWLFYKIYVQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGYNFCKR 1965
Query 2425 HNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLYFDK 2484
HNW C NCD + +TF+S EVA +LS + KR + PT + ++V V + ++L +
Sbjct 1966 HNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVYEACVVDDFVNLKYKA 2025
Query 2485 A-GQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------SKSASV 2536
A K + F D L +A K +L I DG C+ + +K+A+V
Sbjct 2026 AIPGKDNASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEEAKNAAV 2085
Query 2537 YYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSE 2596
YY+Q +C+PIL+LDQAL + VS + D S SV TA
Sbjct 2086 YYAQYLCKPILILDQALYEQL-IVEPVSKSVIDKVCSILSNIISVD---------TAALN 2135
Query 2597 LAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYN- 2655
G D +LS ++ ++ H+ ++E TGD N + +Y
Sbjct 2136 YKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHEVEYTGDGFTNVIPSYGM 2182
Query 2656 KVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNI 2715
+ +TPRD G I+ +A N +V + ++W D + LS+ K + SA K+
Sbjct 2183 DTDKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSDLIKLSDSCLKYLISATVKSGG 2240
Query 2716 PFRLTCATTRQVVNVITTKISL--KGGKIVSTCFKLM---LKATLLCVLAALVC---YIV 2767
F +T + +QV++ T K+ + K G +++ FK K + + C Y
Sbjct 2241 RFFITKSGAKQVISCHTQKLLVEKKAGGVINNTFKWFMSCFKWLFVFYILFTACCLGYYY 2300
Query 2768 MPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYK 2823
M ++ +H Y T + G+K I GV R+I+S D+CF+NK FDA++ G SY+
Sbjct 2301 MEMNKSFVHPMYDVNSTLHVEGFKVIDKGVIREIVSEDNCFSNKFVNFDAFW---GKSYE 2357
Query 2824 NDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFSAVGNIC 2873
N+K+CP+V +I + G + G+PG V ++G F+H ++P F+ +
Sbjct 2358 NNKNCPIVTVVIDGD-GTVAVGVPGFVSWVMDGVMFVHMTQTDRRPWYIPTWFNRE-IVG 2415
Query 2874 YTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELRPDTRYV 2932
YT +I F TS + +A C ++ A P YC++ N G++ + + P Y
Sbjct 2416 YTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYF 2474
Query 2933 LMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALS 2992
+G + P L + +V YCR CE ++ G C+S +WVL N+ Y +
Sbjct 2475 QPNGVRLIVPQQILH-TPYIVKFVSDSYCRGSVCEYTKPGYCVSLDSQWVLFNDEYISKP 2533
Query 2993 GVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYN 3052
GVFCG L+ N+ + V ++ + +I +++ +KF+ VF Y
Sbjct 2534 GVFCGSTVRELMFNMVSTFFTGVNP-NIYIQLATMFLILVVIVLIFAMVIKFQGVFKAYA 2592
Query 3053 HVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPI 3112
+V L+++++ +LC+ S L + V Y Y + + + + + H F I
Sbjct 2593 TIVFTIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASMVTSRNTAIIMHCWLVFTFGLI 2652
Query 3113 VPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYL 3168
VP W+ Y+ I + W + R +++G F ++ AA TF++ ++
Sbjct 2653 VPTWLACCYLGFILYMYTPLVFWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGTEFV 2712
Query 3169 KLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQ 3228
KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG +V+Y
Sbjct 2713 KLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEVVYT 2769
Query 3229 PPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAED 3288
PP+ SI + LQ+GF+K+ PS VE C+V V+ LNGLWL D++YCPRHV+
Sbjct 2770 PPRYSIGVSRLQAGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVL---GK 2826
Query 3289 MLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQ 3347
+ D+L +NH F V N V L V+ ++ +L L+ +N +TPKYKFV+
Sbjct 2827 FSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAVANAETPKYKFVKAN 2886
Query 3348 PGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMEL 3407
G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F YMHH+EL
Sbjct 2887 CGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLEL 2946
Query 3408 PTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVI-------NGDRWFL 3460
P +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I + +W L
Sbjct 2947 PNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQPKW-L 3005
Query 3461 NRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT 3520
T ++ D+N A + P + + LSA TG+ V + + +
Sbjct 3006 ESTTVSIEDYNRWASDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKSAQWGSDP 3062
Query 3521 ILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLILVQST 3575
ILG EDE TP V Q GV Q F V+ W L FL L +V T
Sbjct 3063 ILGQYNFEDELTPESVFNQVGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCAIVLFT 3119
Query 3576 QWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------------ 3623
L F+V+ L +MA+ + VKH A++ FLLP+L T
Sbjct 3120 AVPLKFYVHAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCAEVPFI 3173
Query 3624 --------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLLILMTA 3674
V + + Y P + ++ W+ L + ++ ++ C M + LL+L
Sbjct 3174 YNTLISQVVIFLSQWYDPVVF-DTMVPWMLLPLVLYTAFKCVQGCYMNSFNTSLLMLYQ- 3231
Query 3675 RTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARA 3734
+ ++T N +T + GN W L + + L
Sbjct 3232 ---FMKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTIVLANVSSNSLIGL 3277
Query 3735 IVFVCVE----YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDY 3790
IVF C + Y + L +M+ +G+ C CYFGL+ +N+ F LTLG Y++
Sbjct 3278 IVFKCAKWMLYYCNATYFNNYVLMAVMV--NGIGWLCTCYFGLYWWVNKVFGLTLGKYNF 3335
Query 3791 LVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTSVVLL 3850
VS ++RYM + PPK+ + F NI + GIGG + +ATVQSK+SDVKCT+VVL+
Sbjct 3336 KVSVDQYRYMCLHKVNPPKTVWEVFTTNILIQGIGGDRVLPIATVQSKLSDVKCTTVVLM 3395
Query 3851 SVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINRLCEE 3910
+L +L VE++SK+ A V+LHN IL + D E + ++ +L L + +D+ C++
Sbjct 3396 QLLTKLNVEANSKMHAYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLGEYCDD 3455
Query 3911 MLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLNVAKS 3966
+L LQ++ EFS +PSYA Y A+ YE+ +A+ G ++ L +K+ N+AKS
Sbjct 3456 ILKRSTVLQSVTQEFSHIPSYAEYERAKSIYEKVLADSKNGGVTQQELAAYRKAANIAKS 3515
Query 3967 EFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNII 4026
FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ LN +
Sbjct 3516 VFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLF 3575
Query 4027 NNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDADSKIV 4086
+ A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V DAD +
Sbjct 3576 DQANSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDCVTDADGTEL 3635
Query 4087 QLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAGTTQT 4138
+ + N+AWPL V R V LQNNEL P ++ +C AG Q
Sbjct 3636 HPTSTGSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELMPHGVKTKACVAGVDQA 3695
Query 4139 ACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPK 4198
C+ ++ YY + G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3696 HCSVES-KCYYTSISGSSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGMKVGD 3753
Query 4199 GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDPAKAY 4257
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDPA Y
Sbjct 3754 KVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTY 3813
Query 4258 KDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP--- 4314
Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI HP
Sbjct 3814 CKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGGA 3873
Query 4315 -NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP---LMQS 4370
N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P +
Sbjct 3874 GNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKPSVQSV 3932
Query 4371 ADASTF 4376
A AS F
Sbjct 3933 AVASGF 3938
Score = 218 bits (556), Expect = 9e-55, Method: Composition-based stats.
Identities = 84/358 (23%), Positives = 137/358 (38%), Gaps = 49/358 (14%)
Query 878 EAVVKTL-QPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
E VK L Q V D+L + G +D A L S + F + + A
Sbjct 870 EGAVKALPQKVIDVLGDWGEAVD----AQEQLCQQESTRVISEKSVEGFTGSCDAMAEQA 925
Query 937 ECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEE-------EEEDWLDDTTEQS 989
EE+EI E ++D P + ET +E +E+ + E+
Sbjct 926 IVEEQEIVPVVEQ---SQDVVVFTPADLEVVKETAEEVDEFILISAVPKEEVVSQEKEEP 982
Query 990 EIEPEPEPTPEEPVN----------------QFTGYLKLTDNVAIKCVDIVKEAQSANPM 1033
++E EP + +F Y ++A+ I K
Sbjct 983 QVEQEPTLVVKAQREKKAKKFKVKPATCEKPKFLEYKTCVGDLAVV---IAKALDEFKEF 1039
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL 1093
IVNAAN H+ HGGGVA A+ + DY+K +GP + +C+
Sbjct 1040 CIVNAANEHMSHGGGVAKAIADFCGPDFVEYCADYVKKHGPQQ---KLVTPSFVKGIQCV 1096
Query 1094 -HVVGPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQ 1150
+VVGP + L AAY++ ++ + P+LS+GIFG ++ + +R
Sbjct 1097 NNVVGPRHGDSNLREKLVAAYKSVLVGGVVNYVVPVLSSGIFGVD----FKISIDAMRE- 1151
Query 1151 VYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ + L + +++D KQ+ TED + +SVV KP D +
Sbjct 1152 AFKGCAIRVLLFSLSQEHIDYFDATC---KQKTIYLTEDG-VKYRSVVLKPGDSLGQF 1205
Score = 38.9 bits (89), Expect = 1.6, Method: Composition-based stats.
Identities = 27/104 (26%), Positives = 42/104 (40%), Gaps = 8/104 (8%)
Query 786 NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEV--QGYKNVRIT 843
N + KD+ Y L A N V + G K VTFGE TV E+ ++++
Sbjct 643 NYMFFRFKKDENIYYTPMSQLGAINVVCKAGG----KTVTFGETTVQEIPPPDVVFIKVS 698
Query 844 FELD-ERVDKVLNEKCSV-YTVESGTEVTEFACVVAEAVVKTLQ 885
E E + + + VE+ V + VV E + L+
Sbjct 699 IECCGEPWNTIFKKAYKEPIEVETDLTVEQLLSVVYEKMCDDLK 742
>sp|P0C6Y2|R1AB_IBVBC Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain Beaudette CK) OX=160235 GN=rep
PE=3 SV=1
Length=6629
Score = 2556 bits (6626), Expect = 0.0, Method: Composition-based stats.
Identities = 858/2950 (29%), Positives = 1339/2950 (45%), Gaps = 305/2950 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG Y V + E K +P+ D
Sbjct 1176 KQKTIYLTEDGVKYRSIVLKPGDSLG-QFGQVYAKNKIVFTA---DDVEDKEILYVPTTD 1231
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1232 KSILE----YYGLDAQKYVIYLQTL--AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQA 1285
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A VG+ D + +L +H + +
Sbjct 1286 AKIRFKG-FLTEAWAKLLGGDPTDFVAWCYASCTAKVGDFSDANWLLANLAEHFDADYTN 1344
Query 1723 RVLNV-VCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
L V +CG K+ L G+EA + + + + KT S CG + T +++
Sbjct 1345 AFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLP 1404
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT D + K
Sbjct 1405 YLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAG----QAFDNLAKDRKFGKKS 1460
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y ++ K ++ +
Sbjct 1461 PYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNL------------------ATSS 1502
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFDN D Q + L V PD ++ Y +
Sbjct 1503 KASFDNL----------TDFEQW--YDSNIYESLKVQESPD--------NFDKYVSF--- 1539
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1540 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTD------E 1578
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE 2078
S+ P V++ + +K V GN ++ L E
Sbjct 1579 NSKAPVYYPVLDAIS---------LKAIWVEGNANFVVGHPNY-YSKSLHIPTFW----E 1624
Query 2079 NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNC----- 2133
N +K +++ T+ +N +I K + +++ T+ C
Sbjct 1625 NAENFVKMGDKIGGV----TMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIG 1680
Query 2134 --AKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAG 2191
A +A +V + + + LC T+ R + + K + +
Sbjct 1681 KAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSV 1740
Query 2192 INYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
+ K+ + A L++ + + + T + G S C ++ +S
Sbjct 1741 VASYKTVLCKVVL--ATLLIVWFVYTSNPVMFTGIRVLDFLFEG--SLCGPYKDYGKDSF 1796
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLF 2311
+V + +C F C +CL DSL Y +++ YK + G W Y++F
Sbjct 1797 DV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVF 1849
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIF 2363
F V Y + + NS +L WF V + + F
Sbjct 1850 LILFVKPVAGF---VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNF 1897
Query 2364 FASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1898 MGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSG 1957
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + +
Sbjct 1958 YNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFV 2017
Query 2479 HLYFD-KAGQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------ 2530
+L + K + F D L +A K +L I DG C+ +
Sbjct 2018 NLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEE 2077
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+K+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV
Sbjct 2078 AKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD-------- 2128
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNF 2650
TA G D +LS ++ ++ H+ D++ TGD N
Sbjct 2129 -TAALNYKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTY-NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + ++W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K+ + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELR 2926
+ YT +I F TS + +A C ++ A P YC++ N G++ + +
Sbjct 2409 RE-IVGYTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSII 2466
Query 2927 PDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNE 2986
P Y +G + P L + VV YCR CE + G C+S + +WVL N+
Sbjct 2467 PHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFND 2525
Query 2987 HYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR 3046
Y + GVFCG L+ ++ + V ++ + +I ++V +KF+
Sbjct 2526 EYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQG 2584
Query 3047 VFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWF 3106
VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2585 VFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLV 2644
Query 3107 AMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLL 3162
F IVP W+ Y+ I + W + R +++G F ++ AA TF++
Sbjct 2645 FTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVI 2704
Query 3163 NKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSG 3222
++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG
Sbjct 2705 RGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSG 2761
Query 3223 ADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV 3282
+++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPRHV
Sbjct 2762 VEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHV 2821
Query 3283 ICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
+ + D+L +NH F V + V L V+ ++ +L L+ +N +TPKY
Sbjct 2822 L---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKY 2878
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY 3401
KF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F Y
Sbjct 2879 KFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFY 2938
Query 3402 MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRW--- 3458
MHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2939 MHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFS 2998
Query 3459 ---FLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNG 3515
+L T +++D+N A + P + + LSA TG+ V + + + +
Sbjct 2999 LPKWLESTTVSVDDYNKWAGDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKNSQ 3055
Query 3516 MNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLI 3570
G ILG EDE TP V Q GV Q F V+ W L FL L
Sbjct 3056 WGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCA 3112
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------- 3623
+V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3113 IVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCA 3166
Query 3624 -------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLL 3669
V + + Y P + ++ W+ L + ++ ++ C M + LL
Sbjct 3167 EVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLL 3225
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
+L + ++T N +T + GN W L + +
Sbjct 3226 MLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLANVSSN 3270
Query 3730 FLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F LTLG
Sbjct 3271 SLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVFGLTLG 3329
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SDVKCT+
Sbjct 3330 KYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTT 3389
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINR 3906
VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L + +D++
Sbjct 3390 VVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSE 3449
Query 3907 LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLN 3962
C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L +K+ N
Sbjct 3450 YCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAAN 3509
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ L
Sbjct 3510 IAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKL 3569
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V+DAD
Sbjct 3570 NVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDAD 3629
Query 4083 SKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAG 4134
+ + + N+AWPL V R V LQNNEL P ++ +C AG
Sbjct 3630 GTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAG 3689
Query 4135 TTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVT 4194
Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3690 VDQAHCSVES-KCYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGM 3747
Query 4195 DTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDP 4253
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDP
Sbjct 3748 KVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDP 3807
Query 4254 AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH 4313
A Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI H
Sbjct 3808 ADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAH 3867
Query 4314 P----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP--- 4366
P N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P
Sbjct 3868 PGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSS 3926
Query 4367 LMQSADASTF 4376
+ A AS F
Sbjct 3927 VQSVAGASDF 3936
Score = 173 bits (438), Expect = 4e-41, Method: Composition-based stats.
Identities = 74/354 (21%), Positives = 132/354 (37%), Gaps = 46/354 (13%)
Query 879 AVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAEC 938
AV Q V D+L + G +D A L ++ + + +
Sbjct 872 AVKPLPQKVVDVLGDWGEAVD----AQEQLCQQEPLQHTFEEPVENSTGSSKTMTEQVVV 927
Query 939 EEEEIDE-------------TCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDT 985
E++E+ E T ++ L F E V +++ + +
Sbjct 928 EDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEEVVSQKDGAQ-IKQEP 986
Query 986 TEQSEIEPEPE--------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVN 1037
+ + + E + T E+P +F Y ++ + I K IVN
Sbjct 987 IQVVKPQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLTVV---IAKALDEFKEFCIVN 1041
Query 1038 AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL-HVV 1096
AAN H+ HG GVA A+ + +DY+K +GP + +C+ +VV
Sbjct 1042 AANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---RLVTPSFVKGIQCVNNVV 1098
Query 1097 GPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIA 1154
GP + L AAY+N ++ + P+LS GIFG ++ + +R +
Sbjct 1099 GPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD----FKMSIDAMRE-AFEG 1153
Query 1155 VNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ L + +++D KQ+ TED + +S+V KP D +
Sbjct 1154 CTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSIVLKPGDSLGQF 1203
Score = 40.9 bits (94), Expect = 0.40, Method: Composition-based stats.
Identities = 40/255 (16%), Positives = 86/255 (34%), Gaps = 28/255 (11%)
Query 635 LSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVT 694
+ V+F W+ + IV V + C + +D ++ + +
Sbjct 512 FTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYK------S 565
Query 695 IAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSE 754
L ++ + G+++ G E + +++ ++ S D + +
Sbjct 566 FKKCALGRIHGD--LLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDD 623
Query 755 EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFR 814
+ +N ++ D + KD+ Y L A N V +
Sbjct 624 VTLPENQPGHMVQIEDDGKNY------------MFFRFKKDENIYYTPMSQLGAINVVCK 671
Query 815 LKGGAPIKGVTFGEDTVWEV--QGYKNVRITFELD-ERVDKVLNEKCSV-YTVESGTEVT 870
G K VTFGE TV E+ ++++ E E + + + V++ V
Sbjct 672 AGG----KTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVE 727
Query 871 EFACVVAEAVVKTLQ 885
+ V+ E + L+
Sbjct 728 QLLSVIYEKMCDDLK 742
>sp|P0C6Y1|R1AB_IBVB Replicase polyprotein 1ab OS=Avian infectious
bronchitis virus (strain Beaudette) OX=11122 GN=rep PE=1
SV=1
Length=6629
Score = 2556 bits (6626), Expect = 0.0, Method: Composition-based stats.
Identities = 858/2950 (29%), Positives = 1339/2950 (45%), Gaps = 305/2950 (10%)
Query 1543 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDD 1602
K ++ T D + ++ + G QFG Y V + E K +P+ D
Sbjct 1176 KQKTIYLTEDGVKYRSIVLKPGDSLG-QFGQVYAKNKIVFTA---DDVEDKEILYVPTTD 1231
Query 1603 TLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQ 1662
E Y+ LD Y+ L +KW ++W D NC++SS ++ LQ
Sbjct 1232 KSILE----YYGLDAQKYVIYLQTL--AQKWNVQYRDNFLILEWRDGNCWISSAIVLLQA 1285
Query 1663 LEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAK 1722
+++F L EA+ + GD +F A A VG+ D + +L +H + +
Sbjct 1286 AKIRFKG-FLTEAWAKLLGGDPTDFVAWCYASCTAKVGDFSDANWLLANLAEHFDADYTN 1344
Query 1723 RVLNV-VCKHCGQKTTTLTGVEAVM-YMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS 1780
L V +CG K+ L G+EA + + + + KT S CG + T +++
Sbjct 1345 AFLKKRVSCNCGIKSYELRGLEACIQPVRATNLLHFKTQYSNCPTCGANNTDEVIEASLP 1404
Query 1781 FVMMSAPPAEYKLQ-QGTFLCANEYTGNYQCGH-YTHITAKETLYRIDGAHLTKMSEYKG 1838
++++ A + + + G+ GH YT D + K
Sbjct 1405 YLLLFATDGPATVDCDEDAVGTVVFVGSTNSGHCYTQAAG----QAFDNLAKDRKFGKKS 1460
Query 1839 PVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLP 1898
P Y ++ K ++ +
Sbjct 1461 PYITAMYTRFAFKNETSLPVAKQSKGKSKSVKEDVSNL------------------ATSS 1502
Query 1899 NASFDNFKLTCSNTKFADDLNQMTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKK 1958
ASFDN D Q + L V PD ++ Y +
Sbjct 1503 KASFDNL----------TDFEQW--YDSNIYESLKVQESPD--------NFDKYVSF--- 1539
Query 1959 GAKLLHKPIVWHINQATTKTTFKPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLAC 2018
T + + P T +R + S + + F DT
Sbjct 1540 ---------------TTKEDSKLPLTLKVRGIKSVVDFRSKDGFIYKLTPDTD------E 1578
Query 2019 ESQQPTSEEVVENPTIQKEVIECDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVE 2078
S+ P V++ + +K V GN ++ L E
Sbjct 1579 NSKAPVYYPVLDAIS---------LKAIWVEGNANFVVGHPNY-YSKSLHIPTFW----E 1624
Query 2079 NTSITIKKPNELSLALGLKTIATHGIAAINSVPWSKILAYVKPFLGQAAITTSNC----- 2133
N +K +++ T+ +N +I K + +++ T+ C
Sbjct 1625 NAENFVKMGDKIGGV----TMGLWRAEHLNKPNLERIFNIAKKAIVGSSVVTTQCGKLIG 1680
Query 2134 --AKRLAQRVFNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLCLDAG 2191
A +A +V + + + LC T+ R + + K + +
Sbjct 1681 KAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLMFFLFYFLKASVKSV 1740
Query 2192 INYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSS 2251
+ K+ + A L++ + + + T + G S C ++ +S
Sbjct 1741 VASYKTVLCKVVL--ATLLIVWFVYTSNPVMFTGIRVLDFLFEG--SLCGPYKDYGKDSF 1796
Query 2252 NVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLF 2311
+V + +C F C +CL DSL Y +++ YK + G W Y++F
Sbjct 1797 DV--LRYCADDFICRVCLHDKDSLHLYKHAYSVE---QVYKDAAS--GFIFNWNWLYLVF 1849
Query 2312 TKFFYLLGLSAIMQVFFGYFASHFISNS--------WLMWFIISIVQMAPVSAMVRMYIF 2363
F V Y + + NS +L WF V + + F
Sbjct 1850 LILFVKPVAGF---VIICYCVKYLVLNSTVLQTGVCFLDWF---------VQTVFSHFNF 1897
Query 2364 FASFYYIWKSY-----VHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGG 2418
+ +Y W Y VH + C TC +C + R+ R E + +V G K+ +VY N G
Sbjct 1898 MGAGFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSG 1957
Query 2419 RGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGAL 2478
FCK HNW C NCD + +TF+S EVA +LS + KR + PT + ++VD + + +
Sbjct 1958 YNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDFV 2017
Query 2479 HLYFD-KAGQKTYERHPLSHFVNLDNL-RANNTKGSLPINVIVFDGKSKCDESA------ 2530
+L + K + F D L +A K +L I DG C+ +
Sbjct 2018 NLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHALEE 2077
Query 2531 SKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALV 2590
+K+A++YY+Q +C+PIL+LDQAL + VS + D S+ SV
Sbjct 2078 AKNAAIYYAQYLCKPILILDQALYEQLV-VEPVSKSVIDKVCSILSSIISVD-------- 2128
Query 2591 ATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNF 2650
TA G D +LS ++ ++ H+ D++ TGD N
Sbjct 2129 -TAALNYKAGTLRDALLSI-------------TKDEEAVDMAIFCHNHDVDYTGDGFTNV 2174
Query 2651 MLTY-NKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSA 2709
+ +Y +TPRD G I+ +A N +V + ++W + + LS+ K + SA
Sbjct 2175 IPSYGIDTGKLTPRDRGFLINADASIANLRVKNAP--PVVWKFSELIKLSDSCLKYLISA 2232
Query 2710 AKKNNIPFRLTCATTRQVVNVITTKISL--KGGKIVS---TCFKLMLKATLLCVLAALVC 2764
K+ + F +T + +QV+ T K+ + K G IVS CFK K L+ + C
Sbjct 2233 TVKSGVRFFITKSGAKQVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTAC 2292
Query 2765 ---YIVMPVHTLSIHDGY----TNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQ 2817
Y M V +H Y T + G+K I GV R+I+ D CF+NK FDA++
Sbjct 2293 CSGYYYMEVSKSFVHPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFW-- 2350
Query 2818 RGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAING-DFLH---------FLPRVFS 2867
G Y N ++CP+V A+I + G + G+PG V ++G F+H ++P F+
Sbjct 2351 -GRPYDNSRNCPIVTAVIDGD-GTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFN 2408
Query 2868 AVGNICYTPSKLIEYSDFATSACVLAAECTIFKDAMGKPVPYCYD-TNLLEGSISYSELR 2926
+ YT +I F TS + +A C ++ A P YC++ N G++ + +
Sbjct 2409 RE-IVGYTQDSIITEGSFYTSIALFSARC-LYLTASNTPQLYCFNGDNDAPGALPFGSII 2466
Query 2927 PDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNE 2986
P Y +G + P L + VV YCR CE + G C+S + +WVL N+
Sbjct 2467 PHRVYFQPNGVRLIVPQQILH-TPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFND 2525
Query 2987 HYRALSGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRR 3046
Y + GVFCG L+ ++ + V ++ + +I ++V +KF+
Sbjct 2526 EYTSKPGVFCGSTVRELMFSMVSTFFTGVNP-NIYMQLATMFLILVVVVLIFAMVIKFQG 2584
Query 3047 VFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWF 3106
VF Y V L+++++ ILC+ S L + V Y Y + + + + H
Sbjct 2585 VFKAYATTVFITMLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLV 2644
Query 3107 AMFSPIVPFWITAIYVFCISLKH---CHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLL 3162
F IVP W+ Y+ I + W + R +++G F ++ AA TF++
Sbjct 2645 FTFGLIVPTWLACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVI 2704
Query 3163 NKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSG 3222
++KL +E ++ YL+ Y + KY+SG Y +A LA AL+ + NSG
Sbjct 2705 RGSEFVKLTNEIG---DKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSG 2761
Query 3223 ADVLYQPPQTSITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHV 3282
+++Y PP+ SI + LQSGF+K+ PS VE C+V V+ LNGLWL DT+YCPRHV
Sbjct 2762 VEIVYTPPRYSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHV 2821
Query 3283 ICTAEDMLNPNYEDLLIRKSNHSFLVQAGN-VQLRVIGHSMQNCLLRLKVDTSNPKTPKY 3341
+ + D+L +NH F V + V L V+ ++ +L L+ +N +TPKY
Sbjct 2822 L---GKFSGDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKY 2878
Query 3342 KFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCY 3401
KF++ G +F++ Y G+ G+Y MR N TI+ SFL G+CGSVGFNI+ V+F Y
Sbjct 2879 KFIKANCGDSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFY 2938
Query 3402 MHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRW--- 3458
MHH+ELP +H GTDL G+FYG +VD + AQ D +T N++AWLYAA+I+
Sbjct 2939 MHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFS 2998
Query 3459 ---FLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNG 3515
+L T +++D+N A + P + + LSA TG+ V + + + +
Sbjct 2999 LPKWLESTTVSVDDYNKWAGDNGFTPFSTST--AITKLSAITGVDVCKLLRTIM-VKNSQ 3055
Query 3516 MNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWM-----LLTFLTSLLI 3570
G ILG EDE TP V Q GV Q F V+ W L FL L
Sbjct 3056 WGGDPILGQYNFEDELTPESVFNQIGGVRLQSSF---VRKATSWFWSRCVLACFLFVLCA 3112
Query 3571 LVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLAT------- 3623
+V T L F+VY L +MA+ + VKH A++ FLLP+L T
Sbjct 3113 IVLFTAVPLKFYVYAAVIL-----LMAVLFIS-FTVKHVMAYMDTFLLPTLITVIIGVCA 3166
Query 3624 -------------VAYFNMVYMPASWVMRIMTWLELADTSLSGYR-LKDCVMYASALVLL 3669
V + + Y P + ++ W+ L + ++ ++ C M + LL
Sbjct 3167 EVPFIYNTLISQVVIFLSQWYDPVVF-DTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLL 3225
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
+L + ++T N +T + GN W L + +
Sbjct 3226 MLYQ----FVKLGFVIYTSSNTLTAYTE---GN--------WELFFELVHTTVLANVSSN 3270
Query 3730 FLARAIVFVCVE---YYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLG 3786
L VF C + YY N + ++V C +G+ C CYFGL+ +N+ F LTLG
Sbjct 3271 SLIGLFVFKCAKWMLYYCNATYLNNYVLMAVMVNC-IGWLCTCYFGLYWWVNKVFGLTLG 3329
Query 3787 VYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMSDVKCTS 3846
Y++ VS ++RYM + PPK+ + F NI + GIGG + +ATVQ+K+SDVKCT+
Sbjct 3330 KYNFKVSVDQYRYMCLHKINPPKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTT 3389
Query 3847 VVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINR 3906
VVL+ +L +L VE++SK+ V+LHN IL + D E + ++ +L L + +D++
Sbjct 3390 VVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSE 3449
Query 3907 LCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVAN----GDSEVVLKKLKKSLN 3962
C+++L LQ++ EFS +PSYA Y A+ YE+ + + G ++ L +K+ N
Sbjct 3450 YCDDILKRSTVLQSVTQEFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAAN 3509
Query 3963 VAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDAL 4022
+AKS FDRD A+Q+KL+ MA++AMT MYK+AR D+RAK+ S++ +LF+ML+K+D++ L
Sbjct 3510 IAKSVFDRDLAVQKKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKL 3569
Query 4023 NNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVDAD 4082
N + + A G VPL +P+ + KL +V+PD T+ +G TY++ +W I V+DAD
Sbjct 3570 NVLFDQASSGVVPLATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDAD 3629
Query 4083 SKIVQLSEINMD-----NSPNLAWPLIVTALRANSA---VKLQNNELSPVALRQMSCAAG 4134
+ + + N+AWPL V R V LQNNEL P ++ +C AG
Sbjct 3630 GTELHPTSTGSGLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAG 3689
Query 4135 TTQTACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVT 4194
Q C+ ++ YY N G V A+ S + +LK A F G IY +L+PPC+F
Sbjct 3690 VDQAHCSVES-KCYYTNISGNSVVAAITSSNPNLKVASFLNEAGN-QIYVDLDPPCKFGM 3747
Query 4195 DTPKGPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQA-GNATEVPANSTVLSFCAFAVDP 4253
+V YLYFIK ++ RGMVLG+++ V LQ+ G+ TE +LS C+FAVDP
Sbjct 3748 KVGVKVEVVYLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDP 3807
Query 4254 AKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDH 4313
A Y Y+A+G QP+ NCVKML H G+G AIT P DQ+S+GGAS CLYCR HI H
Sbjct 3808 ADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAH 3867
Query 4314 P----NPKGFCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREP--- 4366
P N G C KG +VQIPTT DPVGF LRN VCTVC W GYGC CD LR+P
Sbjct 3868 PGSVGNLDGRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSS 3926
Query 4367 LMQSADASTF 4376
+ A AS F
Sbjct 3927 VQSVAGASDF 3936
Score = 173 bits (438), Expect = 4e-41, Method: Composition-based stats.
Identities = 74/354 (21%), Positives = 132/354 (37%), Gaps = 46/354 (13%)
Query 879 AVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAEC 938
AV Q V D+L + G +D A L ++ + + +
Sbjct 872 AVKPLPQKVVDVLGDWGEAVD----AQEQLCQQEPLQHTFEEPVENSTGSSKTMTEQVVV 927
Query 939 EEEEIDE-------------TCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDT 985
E++E+ E T ++ L F E V +++ + +
Sbjct 928 EDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEEVVSQKDGAQ-IKQEP 986
Query 986 TEQSEIEPEPE--------PTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVN 1037
+ + + E + T E+P +F Y ++ + I K IVN
Sbjct 987 IQVVKPQREKKAKKFKVKPATCEKP--KFLEYKTCVGDLTVV---IAKALDEFKEFCIVN 1041
Query 1038 AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCL-HVV 1096
AAN H+ HG GVA A+ + +DY+K +GP + +C+ +VV
Sbjct 1042 AANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQ---RLVTPSFVKGIQCVNNVV 1098
Query 1097 GPNLNAGEDIQLLKAAYENFNSQDIL--LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIA 1154
GP + L AAY+N ++ + P+LS GIFG ++ + +R +
Sbjct 1099 GPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVD----FKMSIDAMRE-AFEG 1153
Query 1155 VNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ L + +++D KQ+ TED + +S+V KP D +
Sbjct 1154 CTIRVLLFSLSQEHIDYFDVTC---KQKTIYLTEDG-VKYRSIVLKPGDSLGQF 1203
Score = 40.9 bits (94), Expect = 0.40, Method: Composition-based stats.
Identities = 40/255 (16%), Positives = 86/255 (34%), Gaps = 28/255 (11%)
Query 635 LSAGVEFLKDAWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVT 694
+ V+F W+ + IV V + C + +D ++ + +
Sbjct 512 FTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYK------S 565
Query 695 IAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSE 754
L ++ + G+++ G E + +++ ++ S D + +
Sbjct 566 FKKCALGRIHGD--LLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDD 623
Query 755 EVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFR 814
+ +N ++ D + KD+ Y L A N V +
Sbjct 624 VTLPENQPGHMVQIEDDGKNY------------MFFRFKKDENIYYTPMSQLGAINVVCK 671
Query 815 LKGGAPIKGVTFGEDTVWEV--QGYKNVRITFELD-ERVDKVLNEKCSV-YTVESGTEVT 870
G K VTFGE TV E+ ++++ E E + + + V++ V
Sbjct 672 AGG----KTVTFGETTVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVE 727
Query 871 EFACVVAEAVVKTLQ 885
+ V+ E + L+
Sbjct 728 QLLSVIYEKMCDDLK 742
>sp|Q98VG9|R1AB_FIPV Replicase polyprotein 1ab OS=Feline coronavirus
(strain FIPV WSU-79/1146) OX=33734 GN=rep PE=1 SV=2
Length=6709
Score = 2549 bits (6606), Expect = 0.0, Method: Composition-based stats.
Identities = 727/2284 (32%), Positives = 1123/2284 (49%), Gaps = 141/2284 (6%)
Query 2145 YMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAKLC--LDAGINYVKSPKFSK 2202
Y F ++ F + K K V++ + +
Sbjct 1849 YADVFFMAGDKILRFLLEVFKYLLVVFMCLRKSKMPKVKVKPPHVFRNLGAKVRTLNYVR 1908
Query 2203 LFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGS 2262
+ + L + + + C+G + Y NSS V + + C S
Sbjct 1909 QLNKPALWRYIKLVLLLIALYHFFYLFVSIPVVHKLACSGSVQAYSNSSFVKS-EVCGNS 1967
Query 2263 FPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSA 2322
C CL+ D L + L+ YK D + L+Y +F F +
Sbjct 1968 ILCKACLASYDELADFDHLQVSW----DYKSDPLWNRVIQ---LSYFIFLAVFG----NN 2016
Query 2323 IMQVFFGYFASHFISNSWLMWF-------IISIVQMAPVSAMVRMYIFFASFYYIWKSYV 2375
++ YF S ++ N WL +F + +V +S + + K
Sbjct 2017 YVRCLLMYFVSQYL-NLWLSYFGYVKYSWFLHVVNFESISVEFVIIVVVFKAVLALK--- 2072
Query 2376 HIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTF 2435
HI C + +C C K R TR+ +VNG ++ YV+ANG CK HN+ C NCD++
Sbjct 2073 HIFLPCNNPSCKTCSKIARQTRIPIQVVVNGSMKTVYVHANGTGKLCKKHNFYCKNCDSY 2132
Query 2436 CTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY---------FDKAG 2486
TFI DE+ RDLS K+ + TD+S V V +G Y +D
Sbjct 2133 GFDHTFICDEIVRDLSNSIKQTVYATDRSYQEVTKVECTDGFYRFYVGEEFTAYDYDVKH 2192
Query 2487 QKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMCQPI 2546
+K + L LD+ N GS ++ ++ VY+SQL+ +PI
Sbjct 2193 KKYSSQEVLKTMFLLDDFIVYNPSGSSL--------------ASVRNVCVYFSQLIGRPI 2238
Query 2547 LLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVALDGV 2606
+++ L+ D+ S + +F+A + +F+V + + K L E K LD
Sbjct 2239 KIVNSELLEDL--SVDFKGALFNAKKNVIKNSFNVDVSECKNL-----EECYKLCNLDVT 2291
Query 2607 LSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKV--ENMTPRD 2664
STF A +H + +T S NNF + K ++ D
Sbjct 2292 FSTFEMAINN------------------AHRFGILITDRSFNNFWPSKIKPGSSGVSAMD 2333
Query 2665 LGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTCATT 2724
+G C+ +A+ +NA+V S++W +D+ +LS +K + + + F LT
Sbjct 2334 IGKCMTFDAKIVNAKVLTQRGKSVVWLSQDFSTLSSTAQKVLVKTFVEEGVNFSLTFNAV 2393
Query 2725 RQVVNVI----TTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYT 2780
++ T +S K G K + K C++ + Y + V++++
Sbjct 2394 GSDEDLPYERFTESVSAKSGSGFFDVLKQL-KQLFWCLVLFITLYGLCSVYSVATQSYID 2452
Query 2781 N-EIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKN-DKSCPVVAA-IITR 2837
+ E Y I++GV + + +C N + GF WF + G DKSCP+V +
Sbjct 2453 SAEGYDYMVIKNGVVQSFDDSINCVHNTYKGFAVWFKAKHGFVPTFDKSCPIVLGTVFDL 2512
Query 2838 EIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAECT 2897
+P +P V A+ G L F V N+CY + + CV + CT
Sbjct 2513 GNMRPIPDVPAYV--ALVGRSLVFAINAAFGVTNVCYDHTGAAVSKNSYFDTCVFNSACT 2570
Query 2898 IFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFD 2957
G V YC L+EG+ YSEL PD Y G++++ P +R V T
Sbjct 2571 TLTGIGGT-VVYCAKQGLVEGAKLYSELLPDYYYEHASGNMVKIPAIIRSFGLRFVKTQA 2629
Query 2958 AEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGA 3017
YCR G C S+ G C +V + E G CG + N+F +
Sbjct 2630 TTYCRVGECTESQAGFCFGGDNWFVYDKEF---GDGYICGSSTLGFFKNVFALFNSNMSV 2686
Query 3018 LDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSF 3077
+ S +++A +IA L Y +KF+++FG+ +V ++ L+ + V +F
Sbjct 2687 VATSGAMLANIVIACLAIAVCYGVLKFKKIFGDCTLLVVM-IIVTLVVNNVSYFVTQNTF 2745
Query 3078 LPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAMFSPIVPFWITAIYVFCISLKHCHWFFN 3135
VY++ Y ++ T +++ L + + + P+++ +Y+ F
Sbjct 2746 FMIVYAIIY----YFTTRKLAYPGVLDAGFIIAYLNMAPWYVLVLYIMVFLYDSLPSLFK 2801
Query 3136 NYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYF 3194
+ +F G F +FE AA+ TF+++ Y L + T L + Y +NKYKY+
Sbjct 2802 LKVTTN-LFEGDKFVGSFESAAMGTFVIDMRSYETLVNST--SLDRIKSYANSFNKYKYY 2858
Query 3195 SGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGKVE 3254
+G++ YR A HL KAL D+S S D+LY PP S+ S LQSG RKMA PSG VE
Sbjct 2859 TGSMGEADYRMACYAHLGKALMDYSVSRNDMLYTPPTVSVNST-LQSGLRKMAQPSGVVE 2917
Query 3255 GCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQ 3314
C+V+V G LNGLWL D V CPRHVI + + NYE+ L H+F + N
Sbjct 2918 PCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSRV-INYENELSSVRLHNFSIAKNNAF 2976
Query 3315 LRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNH 3374
L V+ + L LKV+ NP TP++KF ++PG++F++LACY G P VY MR
Sbjct 2977 LGVVSAKYKGVNLVLKVNQVNPNTPEHKFKSVRPGESFNILACYEGCPGSVYGVNMRSQG 3036
Query 3375 TIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAA 3434
TIKGSF+ G+CGSVG+ ++ + F YMHH+EL G H G++LEG+ YG + D+ + Q
Sbjct 3037 TIKGSFIAGTCGSVGYVLENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLE 3096
Query 3435 GTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLS 3494
GT+ + NV+A+LYAA+ING+RWF+ + TL +N A ++ + D L+
Sbjct 3097 GTNVMSSDNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVS--TDAFNMLA 3154
Query 3495 AQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVK 3554
A+TG +V + + L G GRTIL L DEFTP +V+RQ GV Q K +
Sbjct 3155 AKTGYSVEKLLECIVRL-NKGFGGRTILSYGSLCDEFTPTEVIRQMYGVNLQSGKVKSI- 3212
Query 3555 GTHHWMLLTFLTSLLILVQSTQWSLFF----FVYEN-AFLPFTLGIMAIAACAMLL-VKH 3608
+T++ IL W FF F + N F+ L I + + ++ +KH
Sbjct 3213 ------FYPMMTAIAILFAF--WLEFFMYTPFTWINPTFVSVVLAITTLVSVLLVAGIKH 3264
Query 3609 KHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVL 3668
K F F++PS+ N+V+ ++ + +E +T+ ++ ++ +V+
Sbjct 3265 KMLFFMSFVMPSVILATAHNVVWD-MTYYESLQVLVENVNTTFLPVDMQGVMLALFCVVV 3323
Query 3669 LILMTART------VYDDAARRVWTLMNVITLVYKVYYGNALD----QAISMWALVISVT 3718
++ T R + A ++ + N++ L+ + D ++M ++IS+T
Sbjct 3324 FVICTIRFFTCKQSWFSLFATTIFVMFNIVKLLGMIGEPWTDDHFLLCLVNMLTMLISLT 3383
Query 3719 SNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLN 3778
+ VV +A IV ++ P ++C+ ++Y GY CCY+G+ +N
Sbjct 3384 TKDWFVVFASYKVAYYIVVYVMQ--PAFVQDFGFVKCVSIIYMACGYLFCCYYGILYWVN 3441
Query 3779 RYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSK 3838
R+ +T GVY + VS E +YM + L PK++ DA L+ KL+GIGG IK++TVQSK
Sbjct 3442 RFTCMTCGVYQFTVSPAELKYMTANNLSAPKTAYDAMILSFKLMGIGGGRNIKISTVQSK 3501
Query 3839 MSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSM 3898
++++KCT+VVLL +L ++ VES+SK W CV LHN+I L D EK+++L++ LS
Sbjct 3502 LTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPDAVLEKLLALIAFFLSK 3561
Query 3899 QGAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLK 3958
D++ L E +N LQ++AS +++LPS+ AY A+ E+A N S +LK+L
Sbjct 3562 HNTCDLSDLIESYFENTTILQSVASAYAALPSWIAYEKARADLEEAKKNDVSPQLLKQLT 3621
Query 3959 KSLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLD 4018
K+ N+AKSEF+R+A++Q+KL+KMA+QA MYK+AR+ D+++K+ SAM ++LF ML+KLD
Sbjct 3622 KACNIAKSEFEREASVQKKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLD 3681
Query 4019 NDALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQV 4078
++N II AR+G +PL+IIP +A +L+VV P+ N YA A+W I +V
Sbjct 3682 MSSVNTIIEQARNGVLPLSIIPAASATRLIVVTPNLEVLSKVRQENNVHYAGAIWSIVEV 3741
Query 4079 VDADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQT 4138
DA+ V L E+ N N+ WPL +T R KLQNNE+ P L++ + A T
Sbjct 3742 KDANGAQVHLKEVTAANELNITWPLSITCER---TTKLQNNEILPGKLKEKAVKASATID 3798
Query 4139 ACTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPK 4198
+ A + G F+ A ++ +LK+ ++ + I ELE P RF D
Sbjct 3799 GDAYGSGKALMASEGGKSFIYAFIASDSNLKYVKWESN--NDVIPIELEAPLRFYVDGVN 3856
Query 4199 GPKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYK 4258
GP+VKYLYF+K LN L RG VLG + ATVRLQAG TE P+NS +L+ CAFA DPAKAY
Sbjct 3857 GPEVKYLYFVKSLNTLRRGAVLGYIGATVRLQAGKPTEHPSNSGLLTLCAFAPDPAKAYV 3916
Query 4259 DYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKG 4318
D + G QP+TNCVKML G G AIT E+N Q+S+GGAS C+YCRCH++HP G
Sbjct 3917 DAVKRGMQPVTNCVKMLSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHPAIDG 3976
Query 4319 FCDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
C KGK+VQ+PT DP+ F + N VC VCG W GC CD R + + ++LN
Sbjct 3977 LCRFKGKFVQVPTG-TQDPIRFCIENEVCVVCGCWLTNGCMCD--RTSIQGTTIDQSYLN 4033
Query 4379 GFAV 4382
V
Sbjct 4034 ECGV 4037
Score = 240 bits (612), Expect = 3e-61, Method: Composition-based stats.
Identities = 71/329 (22%), Positives = 117/329 (36%), Gaps = 24/329 (7%)
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVN 1589
D+ + + TI + T D N V + TYG+Q G + DVT P V+
Sbjct 1486 DQERVTIENFFNGTIPIKVTEDTVNQKRVSVALDKTYGEQLKGTVVIKDKDVTNQLPSVS 1545
Query 1590 HEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADN 1649
G+ L + YY + + + + ++ K DN
Sbjct 1546 DVGEKVVK-----ALDVDWNAYYGFPNAAAFSA---SSHDAYEFDVVTHNNFIVHKQTDN 1597
Query 1650 NCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETM 1709
NC+++++ LALQ+L+ + P ++ + A F ++ S T G+ GD T+
Sbjct 1598 NCWVNAICLALQRLKPTWKFPGVKSLWDAFLTRKTAGFVHMLYHISGLTKGQPGDAELTL 1657
Query 1710 THLLQHANLESAKRVLN-VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
L+ + +SA V + C C K T TG + L G CV G
Sbjct 1658 HKLVDLMSSDSAVTVTHTTACDKCA-KVETFTGPVVAAPL-------LVCGTDEICVHGV 1709
Query 1769 DATQYLVQQESSFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRID 1826
+ + + S P + ++C YTG GHYT+ + L +D
Sbjct 1710 HVNVKVTSIRGTVAITSLIGPVVGDVIDATGYIC---YTGLNSRGHYTYYDNRNGL-MVD 1765
Query 1827 GAHLTKMSEYKGPVTDVFYKETSYTTTIK 1855
+ VT T K
Sbjct 1766 ADKAYHFEKNLLQVTTAIASNFVANTPKK 1794
Score = 172 bits (437), Expect = 5e-41, Method: Composition-based stats.
Identities = 74/336 (22%), Positives = 126/336 (38%), Gaps = 35/336 (10%)
Query 913 GEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL---PLEFGASAE 969
+ + M+ + + E+ I + C G + L A+
Sbjct 1248 SQFIVTPTMHAVYTGTTQS---GHYMIEDCIHDYCVDGMGIKPRKHKFYTSTLFLNANVM 1304
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
T + + E + + + +P++ + F K V+ D+
Sbjct 1305 TAKSKTMVEPPVPVEDKCVEDCQ-----SPKDLILPFYKAGK----VSFYQGDLDVLINF 1355
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
P V+VNAAN L+H GGVA A++ T G + K S +Y+K + + G + L
Sbjct 1356 LEPDVLVNAANGDLRHVGGVARAIDVFTGGKLTKRSKEYLKSSKAIAPGNAVLFENVLEH 1415
Query 1090 KKCLHVVGPNLNAGEDIQLLKAAYENF-NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVR 1148
L+ VGP L Y+ +L PL+S GIF K SLQ ++TV
Sbjct 1416 LSVLNAVGPRNGDSRVEGKLCNVYKAIAKCDGKILTPLISVGIFKVKLEVSLQCLLKTV- 1474
Query 1149 TQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP--NTEDSKTEEKSVVQKPVDVKP 1206
D+ L V Y D + +E P TED+ +++ V
Sbjct 1475 -------TDRDLN---VFVYTDQERVTIENFFNGTIPIKVTEDTVNQKRVSVALDKTYGE 1524
Query 1207 KIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHD 1242
++K T + + K +TN+L +D+ K+
Sbjct 1525 QLKG------TVVIKDKDVTNQLPSVSDVGEKVVKA 1554
Score = 95.9 bits (237), Expect = 1e-17, Method: Composition-based stats.
Identities = 66/363 (18%), Positives = 113/363 (31%), Gaps = 40/363 (11%)
Query 1551 VDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFE 1610
V + T V + +Q + + P + + D + ++
Sbjct 1025 VSSVEGETVSVVDVEDFVEQVSLVEENNVLTPAVNP-----DEQLSSVEKKDEVSAKNDP 1079
Query 1611 YYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAP 1670
+ +DE +K + G +K DNNC++++ LQ + FN
Sbjct 1080 WAAAVDEQ---EAEQPKPSLTPFKTTNLNGKIILKQQDNNCWINACCYQLQAFDF-FN-- 1133
Query 1671 ALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCK 1730
+ + + D F A G+ GD + +L + +AK L+ C
Sbjct 1134 --HDLWDGFKKDDVMPFVDFCYAALTLKQGDSGDAEYLLETMLN--DYSTAKVTLSAKCG 1189
Query 1731 HCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFV---MMSAP 1787
CG K L E ++ T + K GV C V+ FV +
Sbjct 1190 -CGVKEIVL---ERTVFKLTPLRNEFKYGVCGDCKQINMCKFASVEGSGVFVHDRIEKQT 1245
Query 1788 PAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTK------MSEYKGPVT 1841
P + T YTG Q GHY Y +DG + S
Sbjct 1246 PVSQFIVTPTMHA--VYTGTTQSGHYMIEDCIHD-YCVDGMGIKPRKHKFYTSTLFLNAN 1302
Query 1842 DVFYKETSYTTTIKPVSYKLDGVTYTE--IEPK--LDGYYKKDNAYYTEQPIDLVPTQPL 1897
+ K + PV E PK + +YK + + +D++
Sbjct 1303 VMTAKSKTMVEPPVPV-----EDKCVEDCQSPKDLILPFYKAGKVSFYQGDLDVLINFLE 1357
Query 1898 PNA 1900
P+
Sbjct 1358 PDV 1360
Score = 67.0 bits (162), Expect = 6e-09, Method: Composition-based stats.
Identities = 52/274 (19%), Positives = 97/274 (35%), Gaps = 12/274 (4%)
Query 746 SHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIKDKEQYCALSPG 805
+ +T+ ++ + + + + G + + G + +D Y G
Sbjct 809 TASVPVTNSGIITTDDWSDPILLEPADYVEPKDNGDVIVIAGYTFYKDEDDHFYPY---G 865
Query 806 LLATNNVFRLKGGAPIKGVTFGED-TVWEVQGYKNVRITFELD-ERVDKVLNEKCSVYTV 863
K G K V+F ++ V E++ VR+ FE D E V +VL +
Sbjct 866 SGMVVQKMYNKMGGGDKSVSFSDNVNVREIEPVTRVRLEFEFDNEVVTQVLEKVIGTKYK 925
Query 864 ESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE-WSVATFYLFDDAGEENFSSRMY 922
GT EF +++ + L + D L G++L+ + T FD + Y
Sbjct 926 FIGTTWEEF----EDSISEKLDKIFDTLAEQGVELEGYFIYDTCGGFDINNPDGVMISQY 981
Query 923 CSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWL 982
D++ + DA E+ + E E+D + +V E D
Sbjct 982 DLNTAADDKSDSDASVEDISLISDNEDVEQIEEDNTST--DDAEDVSSVEGETVSVVDVE 1039
Query 983 DDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNV 1016
D + S +E TP ++ ++ D V
Sbjct 1040 DFVEQVSLVEENNVLTPAVNPDEQLSSVEKKDEV 1073
Score = 60.1 bits (144), Expect = 6e-07, Method: Composition-based stats.
Identities = 81/420 (19%), Positives = 130/420 (31%), Gaps = 65/420 (15%)
Query 180 GAVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIA 239
G YVD CG DG P+ E DY V E+ A
Sbjct 108 GNGAIYVDQYMCGADGKPV---------------IEGEFKDYFG-DEDVIIYEGEEYHCA 151
Query 240 WFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGR 299
W T R +K QT I+ + + P N ++ + P V+K
Sbjct 152 WLTVRDEKPLWQQTLLTIREIQYNLDIPHKLP------NCAIREVAPPVKKNSKVVLSEE 205
Query 300 IRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKAT-CEHCGTENLVIEGPTTCG 358
R +Y ++ S M + + F+ AT CG E+ + T
Sbjct 206 YRKLY---------DIFGSPFMGNGDSLNTCFDSLHFIAATLKCPCGAESSGVGDWTG-- 254
Query 359 YLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYN 418
K C G ++ I T + G + F V Y G
Sbjct 255 -------FKTACCGLHGKVKGV--TLGAVKPGDAIVTSMSAGKGVKFFANSVLQYAGDVE 305
Query 419 KRAYW-VPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEE----- 472
+ W V + + T + E D + S V+ +I F E
Sbjct 306 NVSVWKVIKTFTVNETVCT----TDFEGELNDFIRPESTSPVSCSIKRAFITGEVDDAVH 361
Query 473 VAIILASFSASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTP 532
II ST+ F +L +K V+ CG AW + ++ +L
Sbjct 362 DCIIAGKLDLSTNLFGSA--NLLFKKMPWFVQKCGAI-------FADAWKVVEE--LLCS 410
Query 533 LCGFPSQAAGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLT 592
L Q V+ S+ ++ P ++ ++ D + + LV A + +T
Sbjct 411 LKLTYKQIYDVVASLCTSAFTIMDYK-PVFVVSSNSVKDLVDKCVKILVKAFDVFTQTIT 469
>sp|P0C6V2|R1A_CVPPU Replicase polyprotein 1a OS=Porcine transmissible
gastroenteritis coronavirus (strain Purdue) OX=11151
GN=1a PE=1 SV=1
Length=4017
Score = 2546 bits (6600), Expect = 0.0, Method: Composition-based stats.
Identities = 714/2283 (31%), Positives = 1118/2283 (49%), Gaps = 133/2283 (6%)
Query 2142 FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAK--LCLDAGINYVKSPK 2199
F Y F ++ + + K K L V++
Sbjct 1821 FGRYADMFFMAGDKILRLLLEVFKYLLVLFMCLRSTKMPKVKVKPPLAFKDFGAKVRTLN 1880
Query 2200 FSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFC 2259
+ + + L + + + CNG + Y NSS + + C
Sbjct 1881 YMRQLNKPSVWRYAKLVLLLIAIYNFFYLFVSIPVVHKLTCNGAVQAYKNSSFIKSA-VC 1939
Query 2260 EGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLG 2319
S C CL+ D L + L+ +K D L L+Y F F
Sbjct 1940 GNSILCKACLASYDELADFQHLQVTW----DFKSDPLWNRLVQ---LSYFAFLAVFG--- 1989
Query 2320 LSAIMQVFFGYFASHFISNSWLMWF-------IISIVQMAPVSAMVRMYIFFASFYYIWK 2372
+ ++ F YF S ++ N WL +F + +V +SA + + K
Sbjct 1990 -NNYVRCFLMYFVSQYL-NLWLSYFGYVEYSWFLHVVNFESISAEFVIVVIVVKAVLALK 2047
Query 2373 SYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNC 2432
HI+ C++ +C C + R TR+ +VNG ++ YV+ANG FCK HN+ C NC
Sbjct 2048 ---HIVFACSNPSCKTCSRTARQTRIPIQVVVNGSMKTVYVHANGTGKFCKKHNFYCKNC 2104
Query 2433 DTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY---------FD 2483
D++ +TFI DE+ RDLS K+ + TD+S V V +G Y +D
Sbjct 2105 DSYGFENTFICDEIVRDLSNSVKQTVYATDRSHQEVTKVECSDGFYRFYVGDEFTSYDYD 2164
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+K + L + LD+ + GS NV ++A VY+SQL+
Sbjct 2165 VKHKKYSSQEVLKSMLLLDDFIVYSPSGSALANV--------------RNACVYFSQLIG 2210
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PI +++ L+ D+ S + +F+A + +F+V + + K L E + L
Sbjct 2211 KPIKIVNSDLLEDL--SVDFKGALFNAKKNVIKNSFNVDVSECKNL-----DECYRACNL 2263
Query 2604 DGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKV--ENMT 2661
+ STF A +H + +T S NNF + K ++
Sbjct 2264 NVSFSTFEMAVNN------------------AHRFGILITDRSFNNFWPSKVKPGSSGVS 2305
Query 2662 PRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTC 2721
D+G C+ +A+ +NA+V S++W +D+ +LS +K + + + F LT
Sbjct 2306 AMDIGKCMTSDAKIVNAKVLTQRGKSVVWLSQDFAALSSTAQKVLVKTFVEEGVNFSLTF 2365
Query 2722 ATTRQVVNVI----TTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHD 2777
++ T +S K G + + +L + +C + +
Sbjct 2366 NAVGSDDDLPYERFTESVSPKSGSGFFDVITQLKQIVILVFVFIFICGLCSVYSVATQSY 2425
Query 2778 GYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKN-DKSCPVVAA-II 2835
+ E Y I++G+ + T C N + GF WF + G KSCP+V +
Sbjct 2426 IESAEGYDYMVIKNGIVQPFDDTISCVHNTYKGFGDWFKAKYGFIPTFGKSCPIVVGTVF 2485
Query 2836 TREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAE 2895
E +P +P V +I G L F V N+CY + D CV
Sbjct 2486 DLENMRPIPDVPAYV--SIVGRSLVFAINAAFGVTNMCYDHTGNAVSKDSYFDTCVFNTA 2543
Query 2896 CTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTT 2955
CT G + YC L+EG+ YS+L PD Y G++++ P +R V T
Sbjct 2544 CTTLTGLGGT-IVYCAKQGLVEGAKLYSDLMPDYYYEHASGNMVKLPAIIRGLGLRFVKT 2602
Query 2956 FDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPV 3015
YCR G C S+ G C +V +NE +G CG + N+F +
Sbjct 2603 QATTYCRVGECIDSKAGFCFGGDNWFVYDNEF---GNGYICGNSVLGFFKNVFKLFNSNM 2659
Query 3016 GALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAY 3075
+ S +++ IIA L Y +KF+++FG+ ++ ++ L+ + V
Sbjct 2660 SVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVM-IIVTLVVNNVSYFVTQN 2718
Query 3076 SFLPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAMFSPIVPFWITAIYVFCISLKHCHWF 3133
+F +Y++ Y ++ T +++ L + + + P+++ Y+
Sbjct 2719 TFFMIIYAIVY----YFITRKLAYPGILDAGFIIAYINMAPWYVITAYILVFLYDSLPSL 2774
Query 3134 FNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYK 3192
F + +F G F FE AA+ TF+++ Y + + T + + Y +NKYK
Sbjct 2775 FKLKVSTN-LFEGDKFVGNFESAAMGTFVIDMRSYETIVNST--SIARIKSYANSFNKYK 2831
Query 3193 YFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGK 3252
Y++G++ YR A HL KAL D+S + D+LY PP S+ S LQSG RKMA PSG
Sbjct 2832 YYTGSMGEADYRMACYAHLGKALMDYSVNRTDMLYTPPTVSVNST-LQSGLRKMAQPSGL 2890
Query 3253 VEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN 3312
VE C+V+V+ G LNGLWL D V CPRHVI + + NYE+ + H+F V N
Sbjct 2891 VEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDTTRV-INYENEMSSVRLHNFSVSKNN 2949
Query 3313 VQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRP 3372
V L V+ + L LKV+ NP TP++KF I+ G++F++LACY G P VY MR
Sbjct 2950 VFLGVVSARYKGVNLVLKVNQVNPNTPEHKFKSIKAGESFNILACYEGCPGSVYGVNMRS 3009
Query 3373 NHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQ 3432
TIKGSF+ G+CGSVG+ ++ + F YMHH+EL G H G++ EG+ YG + D+ + Q
Sbjct 3010 QGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLELGNGSHVGSNFEGEMYGGYEDQPSMQ 3069
Query 3433 AAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGP 3492
GT+ + NV+A+LYAA+ING+RWF+ + +L +N A ++ L+ D
Sbjct 3070 LEGTNVMSSDNVVAFLYAALINGERWFVTNTSMSLESYNTWAKTNSFTELSS--TDAFSM 3127
Query 3493 LSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKK 3551
L+A+TG +V + ++ L G GRTIL L DEFTP +V+RQ GV Q GK K
Sbjct 3128 LAAKTGQSVEKLLDSIVRL-NKGFGGRTILSYGSLCDEFTPTEVIRQMYGVNLQAGKVKS 3186
Query 3552 IVKGTHHWMLLTFLTSLLIL-VQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLL-VKHK 3609
+ ++T +T L ++ ++ F ++ F+ L + + + + +KHK
Sbjct 3187 FF-----YPIMTAMTILFAFWLEFFMYTPFTWINP-TFVSIVLAVTTLISTVFVSGIKHK 3240
Query 3610 HAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
F F+LPS+ V N+ + S+ + + +E +T ++ ++ ++
Sbjct 3241 MLFFMSFVLPSVILVTAHNL-FWDFSYYESLQSIVENTNTMFLPVDMQGVMLTVFCFIVF 3299
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQA----------ISMWALVISVTS 3719
+ + R + + ++ + V D+ ++M +++S+T+
Sbjct 3300 VTYSVRFFTCKQSWFSLAVTTILVIFNMVKIFGTSDEPWTENQIAFCFVNMLTMIVSLTT 3359
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
VV +A IV + ++CI +VY GY CCY+G+ +NR
Sbjct 3360 KDWMVVIASYRIAYYIVVCVM--PSAFVSDFGFMKCISIVYMACGYLFCCYYGILYWVNR 3417
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
+ +T GVY + VS E +YM + L PK++ DA L+ KL+G+GGK IK++TVQSK+
Sbjct 3418 FTCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQSKL 3477
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
+++KCT+VVLL +L ++ VES+SK W CV LHN+I L D EK+++L++ LS
Sbjct 3478 TEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKH 3537
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
D++ L E +N LQ++AS +++LPS+ A A+ E+A N S +LK+L K
Sbjct 3538 NTCDLSELIESYFENTTILQSVASAYAALPSWIALEKARADLEEAKKNDVSPQILKQLTK 3597
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS+F+R+A++Q+KL+KMA+QA MYK+AR+ D+++K+ SAM ++LF ML+KLD
Sbjct 3598 AFNIAKSDFEREASVQKKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDM 3657
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
++N II+ AR+G +PL+IIP +A +L+V+ P + N YA A+W I +V
Sbjct 3658 SSVNTIIDQARNGVLPLSIIPAASATRLVVITPSLEVFSKIRQENNVHYAGAIWTIVEVK 3717
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DA+ V L E+ N NL WPL +T R KLQNNE+ P L++ + A T
Sbjct 3718 DANGSHVHLKEVTAANELNLTWPLSITCER---TTKLQNNEIMPGKLKERAVRASATLDG 3774
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
+ A + G F+ A ++ +LK+ ++ + I ELE P RF D G
Sbjct 3775 EAFGSGKALMASESGKSFMYAFIASDNNLKYVKWESN--NDIIPIELEAPLRFYVDGANG 3832
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
P+VKYLYF+K LN L RG VLG + ATVRLQAG TE P+NS++L+ CAF+ DPAKAY D
Sbjct 3833 PEVKYLYFVKNLNTLRRGAVLGYIGATVRLQAGKPTEHPSNSSLLTLCAFSPDPAKAYVD 3892
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
+ G QP+ NCVKML G G A+T EAN Q+S+GGAS C+YCRCH++HP G
Sbjct 3893 AVKRGMQPVNNCVKMLSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHPAIDGL 3952
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNG 4379
C KGK+VQIPT DP+ F + N VC VCG W GC CD R + ++LN
Sbjct 3953 CRYKGKFVQIPTG-TQDPIRFCIENEVCVVCGCWLNNGCMCD--RTSMQSFTVDQSYLNE 4009
Query 4380 FAV 4382
V
Sbjct 4010 CGV 4012
Score = 211 bits (537), Expect = 1e-52, Method: Composition-based stats.
Identities = 73/367 (20%), Positives = 117/367 (32%), Gaps = 32/367 (9%)
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVN 1589
D+ + + +I V T DN N V TYG+Q G + DVT P
Sbjct 1475 DQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKTYGEQLKGTVVIKDKDVTNQLPSAF 1534
Query 1590 HEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADN 1649
G+ D F S Y K++ K DN
Sbjct 1535 DVGQKVIKAIDIDWQAHYGFRDAAAFSASSHDAY--------KFEVVTHSNFIVHKQTDN 1586
Query 1650 NCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETM 1709
NC+++++ LALQ+L+ ++ P ++ + F ++ S GE GD +
Sbjct 1587 NCWINAICLALQRLKPQWKFPGVRGLWNEFLERKTQGFVHMLYHISGVKKGEPGDAELML 1646
Query 1710 THLLQHANLESAKRVLN-VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
L + + V + C C K G + G CV G
Sbjct 1647 HKLGDLMDNDCEIIVTHTTACDKCA-KVEKFVGPVVAAPLAIH-------GTDETCVHGV 1698
Query 1769 DATQYLVQQESSFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETL---- 1822
+ Q + + + S P L+ ++C Y+G+ + GHYT+ + L
Sbjct 1699 SVNVKVTQIKGTVAITSLIGPIIGEVLEATGYIC---YSGSNRNGHYTYYDNRNGLVVDA 1755
Query 1823 ---YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKK 1879
Y + L + V K + K+ E KL
Sbjct 1756 EKAYHFNRDLLQVTTAIASNF--VVKKPQAEERPKNCAFNKVAASPKIVQEQKLLAIESG 1813
Query 1880 DNAYYTE 1886
N TE
Sbjct 1814 ANYALTE 1820
Score = 208 bits (530), Expect = 7e-52, Method: Composition-based stats.
Identities = 89/395 (23%), Positives = 141/395 (36%), Gaps = 49/395 (12%)
Query 875 VVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENF--------SSRMYCSFY 926
+V E V L P+ + N G+ D V T G F +
Sbjct 1171 IVLERAVFKLTPLKESF-NYGVCGDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVK 1229
Query 927 PPDEEEEDDAECEEEEIDETCEHEYGTED----------------DYQGLPLEFGASAET 970
P + + EH Y + + +
Sbjct 1230 PVMHAVYTGTTQNGHYMVDDIEHGYCVDGMGIKPLKKRCYTSTLFINANVMTRAEKPKQE 1289
Query 971 VRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA 1030
+VE+ E++ +++ E E P ++ + F KL+ +D++
Sbjct 1290 FKVEKVEQQPIVEENKSSIEKEEIQSPKNDDLILPFYKAGKLS--FYQGALDVL--INFL 1345
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAK 1090
P VIVNAAN LKH GGVA A++ T G + + S DY+K N + G +
Sbjct 1346 EPDVIVNAANGDLKHMGGVARAIDVFTGGKLTERSKDYLKKNKSIAPGNAVFFENVIEHL 1405
Query 1091 KCLHVVGPNLNAGEDIQLLKAAYENF-NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
L+ VGP L Y+ + +L PL+S GIF + SLQ ++TV
Sbjct 1406 SVLNAVGPRNGDSRVEAKLCNVYKAIAKCEGKILTPLISVGIFNVRLETSLQCLLKTV-- 1463
Query 1150 QVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP--NTEDSKTEEKSVVQKPVDVKPK 1207
ND+ L V Y D + +E P TED+ E+ V +
Sbjct 1464 ------NDRGLN---VFVYTDQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKTYGEQ 1514
Query 1208 IKACIDEVTTTLEETKFLTNKLLLFADINGKLYHD 1242
+K T + + K +TN+L D+ K+
Sbjct 1515 LKG------TVVIKDKDVTNQLPSAFDVGQKVIKA 1543
Score = 103 bits (257), Expect = 5e-20, Method: Composition-based stats.
Identities = 58/271 (21%), Positives = 93/271 (34%), Gaps = 24/271 (9%)
Query 1587 HVNHEGKTFFVLPSDDTLR-SEAFEYYHTLDESF----LGRYMSALNHTKKWKFPQVGGL 1641
E +T V T + E D + +K + G
Sbjct 1024 SSQEEVETVEVADITSTEEDVDIVEVSAKDDPWAAAVDVQEAEQFNPSLPPFKTTNLNGK 1083
Query 1642 TSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGE 1701
+K DNNC++++ LQ + FN EA+ + + GD +F L A + G
Sbjct 1084 IILKQGDNNCWINACCYQLQAFDF-FN----NEAWEKFKKGDVMDFVNLCYAATTLARGH 1138
Query 1702 LGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVS 1761
GD + +L + +AK VL C CG+K L E ++ T ++ GV
Sbjct 1139 SGDAEYLLELMLN--DYSTAKIVLAAKCG-CGEKEIVL---ERAVFKLTPLKESFNYGVC 1192
Query 1762 IPCVCGRDATQYLVQQESSFV---MMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITA 1818
C+ V+ FV + P + + YTG Q GHY
Sbjct 1193 GDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVKPVMHA--VYTGTTQNGHYMVDDI 1250
Query 1819 KETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
+ Y +DG + K T + +
Sbjct 1251 EHG-YCVDGMGIKP--LKKRCYTSTLFINAN 1278
Score = 72.4 bits (176), Expect = 1e-10, Method: Composition-based stats.
Identities = 74/378 (20%), Positives = 120/378 (32%), Gaps = 56/378 (15%)
Query 185 YVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTER 244
YVD CG DG P+ + DY + E+ AW T R
Sbjct 113 YVDQYMCGADGKPV---------------IEGDFKDYFG-DEDIIEFEGEEYHCAWTTVR 156
Query 245 SDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVY 304
+K QT F I+ + + P N + + P V+K + +Y
Sbjct 157 DEKPLNQQTLFTIQEIQYNLDIPHKLP------NCATRHVAPPVKKNSKIVLSEDYKKLY 210
Query 305 PVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKAT-CEHCGTENLVIEGPTTCGYLPTN 363
++ S M C + T F+ AT CG+E+ + T
Sbjct 211 ---------DIFGSPFMGNGDCLSKCFDTLHFIAATLRCPCGSESSGVGDWTG------- 254
Query 364 AVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYW 423
K C G ++ D + T + G + F CV Y G + W
Sbjct 255 --FKTACCGLSGKVKGV--TLGDIKPGDAVVTSMSAGKGVKFFANCVLQYAGDVEGVSIW 310
Query 424 -VPRASADIGSGHT-GITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFS 481
V + + T G G+ + + + +++ I GD II
Sbjct 311 KVIKTFTVDETVCTPGFEGELNDFIKPESKSLVACSVKRAFITGDIDDAVHDCIITGKLD 370
Query 482 ASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAA 541
ST+ F + L +K V+ CG V AW + ++ + L Q
Sbjct 371 LSTNLFGNV--GLLFKKTPWFVQKCGALFV-------DAWKVVEE--LCGSLTLTYKQIY 419
Query 542 GVIRSIFARTLDAANHSI 559
V+ S+ N+
Sbjct 420 EVVASLCTSAFTIVNYKP 437
Score = 47.8 bits (112), Expect = 0.003, Method: Composition-based stats.
Identities = 63/343 (18%), Positives = 111/343 (32%), Gaps = 28/343 (8%)
Query 659 IVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNL-GEVFIAQSKGLY 717
++ ++V D K NK + + I G + FI + +Y
Sbjct 737 LIGNGVKVVCDGCKGFANQLSKGYNKLCNAARNDIEIGGIPFSTFKTPTNTFIEMTDAIY 796
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
+GK L D + + E + +
Sbjct 797 SVIEQGKA----------------LSFRDADVPVVDNGTISTADWSEPILLEPAEYVKPK 840
Query 778 IVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDT-VWEVQG 836
G + + G + +D+ Y G K G K V+F E+ V E+
Sbjct 841 NNGNVIVIAGYTFYKDEDEHFYPY---GFGKIVQRMYNKMGGGDKTVSFSEEVDVQEIAP 897
Query 837 YKNVRITFELD-ERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMG 895
V++ FE D E V VL +GT E++ + L + D L N G
Sbjct 898 VTRVKLEFEFDNEIVTGVLERAIGTRYKFTGTT----WEEFEESISEELDAIFDTLANQG 953
Query 896 IDLDE-WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
++L+ + T FD + Y +E+ + + EEE E+ E + E
Sbjct 954 VELEGYFIYDTCGGFDIKNPDGIMISQY-DINITADEKSEVSASSEEEEVESVEEDPENE 1012
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEP 997
E +S E V E + ++ + E+ + +P
Sbjct 1013 IVEASEGAEGTSSQEEVETVEVADITSTEEDVDIVEVSAKDDP 1055
>sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmissible
gastroenteritis coronavirus (strain Purdue) OX=11151
GN=rep PE=1 SV=1
Length=6684
Score = 2544 bits (6594), Expect = 0.0, Method: Composition-based stats.
Identities = 713/2279 (31%), Positives = 1117/2279 (49%), Gaps = 133/2279 (6%)
Query 2142 FNNYMPYVFTLLFQLCTFTKSTNSRIRASLPTTIAKNSVKSVAK--LCLDAGINYVKSPK 2199
F Y F ++ + + K K L V++
Sbjct 1821 FGRYADMFFMAGDKILRLLLEVFKYLLVLFMCLRSTKMPKVKVKPPLAFKDFGAKVRTLN 1880
Query 2200 FSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFC 2259
+ + + L + + + CNG + Y NSS + + C
Sbjct 1881 YMRQLNKPSVWRYAKLVLLLIAIYNFFYLFVSIPVVHKLTCNGAVQAYKNSSFIKSA-VC 1939
Query 2260 EGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLG 2319
S C CL+ D L + L+ +K D L L+Y F F
Sbjct 1940 GNSILCKACLASYDELADFQHLQVTW----DFKSDPLWNRLVQ---LSYFAFLAVFG--- 1989
Query 2320 LSAIMQVFFGYFASHFISNSWLMWF-------IISIVQMAPVSAMVRMYIFFASFYYIWK 2372
+ ++ F YF S ++ N WL +F + +V +SA + + K
Sbjct 1990 -NNYVRCFLMYFVSQYL-NLWLSYFGYVEYSWFLHVVNFESISAEFVIVVIVVKAVLALK 2047
Query 2373 SYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNC 2432
HI+ C++ +C C + R TR+ +VNG ++ YV+ANG FCK HN+ C NC
Sbjct 2048 ---HIVFACSNPSCKTCSRTARQTRIPIQVVVNGSMKTVYVHANGTGKFCKKHNFYCKNC 2104
Query 2433 DTFCTGSTFISDEVARDLSLQFKRPINPTDQSSYIVDSVAVKNGALHLY---------FD 2483
D++ +TFI DE+ RDLS K+ + TD+S V V +G Y +D
Sbjct 2105 DSYGFENTFICDEIVRDLSNSVKQTVYATDRSHQEVTKVECSDGFYRFYVGDEFTSYDYD 2164
Query 2484 KAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVFDGKSKCDESASKSASVYYSQLMC 2543
+K + L + LD+ + GS NV ++A VY+SQL+
Sbjct 2165 VKHKKYSSQEVLKSMLLLDDFIVYSPSGSALANV--------------RNACVYFSQLIG 2210
Query 2544 QPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFSVPMEKLKALVATAHSELAKGVAL 2603
+PI +++ L+ D+ S + +F+A + +F+V + + K L E + L
Sbjct 2211 KPIKIVNSDLLEDL--SVDFKGALFNAKKNVIKNSFNVDVSECKNL-----DECYRACNL 2263
Query 2604 DGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDLEVTGDSCNNFMLTYNKV--ENMT 2661
+ STF A +H + +T S NNF + K ++
Sbjct 2264 NVSFSTFEMAVNN------------------AHRFGILITDRSFNNFWPSKVKPGSSGVS 2305
Query 2662 PRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSEQLRKQIRSAAKKNNIPFRLTC 2721
D+G C+ +A+ +NA+V S++W +D+ +LS +K + + + F LT
Sbjct 2306 AMDIGKCMTSDAKIVNAKVLTQRGKSVVWLSQDFAALSSTAQKVLVKTFVEEGVNFSLTF 2365
Query 2722 ATTRQVVNVI----TTKISLKGGKIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHD 2777
++ T +S K G + + +L + +C + +
Sbjct 2366 NAVGSDDDLPYERFTESVSPKSGSGFFDVITQLKQIVILVFVFIFICGLCSVYSVATQSY 2425
Query 2778 GYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGGSYKN-DKSCPVVAA-II 2835
+ E Y I++G+ + T C N + GF WF + G KSCP+V +
Sbjct 2426 IESAEGYDYMVIKNGIVQPFDDTISCVHNTYKGFGDWFKAKYGFIPTFGKSCPIVVGTVF 2485
Query 2836 TREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLIEYSDFATSACVLAAE 2895
E +P +P V +I G L F V N+CY + D CV
Sbjct 2486 DLENMRPIPDVPAYV--SIVGRSLVFAINAAFGVTNMCYDHTGNAVSKDSYFDTCVFNTA 2543
Query 2896 CTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSVRVVTT 2955
CT G + YC L+EG+ YS+L PD Y G++++ P +R V T
Sbjct 2544 CTTLTGLGGT-IVYCAKQGLVEGAKLYSDLMPDYYYEHASGNMVKLPAIIRGLGLRFVKT 2602
Query 2956 FDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPV 3015
YCR G C S+ G C +V +NE +G CG + N+F +
Sbjct 2603 QATTYCRVGECIDSKAGFCFGGDNWFVYDNEF---GNGYICGNSVLGFFKNVFKLFNSNM 2659
Query 3016 GALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAY 3075
+ S +++ IIA L Y +KF+++FG+ ++ ++ L+ + V
Sbjct 2660 SVVATSGAMLVNIIIACLAIAMCYGVLKFKKIFGDCTFLIVM-IIVTLVVNNVSYFVTQN 2718
Query 3076 SFLPGVYSVFYLYLTFYFTNDVSFLAHLQ--WFAMFSPIVPFWITAIYVFCISLKHCHWF 3133
+F +Y++ Y ++ T +++ L + + + P+++ Y+
Sbjct 2719 TFFMIIYAIVY----YFITRKLAYPGILDAGFIIAYINMAPWYVITAYILVFLYDSLPSL 2774
Query 3134 FNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYK 3192
F + +F G F FE AA+ TF+++ Y + + T + + Y +NKYK
Sbjct 2775 FKLKVSTN-LFEGDKFVGNFESAAMGTFVIDMRSYETIVNST--SIARIKSYANSFNKYK 2831
Query 3193 YFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFPSGK 3252
Y++G++ YR A HL KAL D+S + D+LY PP S+ S LQSG RKMA PSG
Sbjct 2832 YYTGSMGEADYRMACYAHLGKALMDYSVNRTDMLYTPPTVSVNST-LQSGLRKMAQPSGL 2890
Query 3253 VEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGN 3312
VE C+V+V+ G LNGLWL D V CPRHVI + + NYE+ + H+F V N
Sbjct 2891 VEPCIVRVSYGNNVLNGLWLGDEVICPRHVIASDTTRV-INYENEMSSVRLHNFSVSKNN 2949
Query 3313 VQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRP 3372
V L V+ + L LKV+ NP TP++KF I+ G++F++LACY G P VY MR
Sbjct 2950 VFLGVVSARYKGVNLVLKVNQVNPNTPEHKFKSIKAGESFNILACYEGCPGSVYGVNMRS 3009
Query 3373 NHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQ 3432
TIKGSF+ G+CGSVG+ ++ + F YMHH+EL G H G++ EG+ YG + D+ + Q
Sbjct 3010 QGTIKGSFIAGTCGSVGYVLENGILYFVYMHHLELGNGSHVGSNFEGEMYGGYEDQPSMQ 3069
Query 3433 AAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGP 3492
GT+ + NV+A+LYAA+ING+RWF+ + +L +N A ++ L+ D
Sbjct 3070 LEGTNVMSSDNVVAFLYAALINGERWFVTNTSMSLESYNTWAKTNSFTELSS--TDAFSM 3127
Query 3493 LSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ-GKFKK 3551
L+A+TG +V + ++ L G GRTIL L DEFTP +V+RQ GV Q GK K
Sbjct 3128 LAAKTGQSVEKLLDSIVRL-NKGFGGRTILSYGSLCDEFTPTEVIRQMYGVNLQAGKVKS 3186
Query 3552 IVKGTHHWMLLTFLTSLLIL-VQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLL-VKHK 3609
+ ++T +T L ++ ++ F ++ F+ L + + + + +KHK
Sbjct 3187 FF-----YPIMTAMTILFAFWLEFFMYTPFTWINP-TFVSIVLAVTTLISTVFVSGIKHK 3240
Query 3610 HAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLL 3669
F F+LPS+ V N+ + S+ + + +E +T ++ ++ ++
Sbjct 3241 MLFFMSFVLPSVILVTAHNL-FWDFSYYESLQSIVENTNTMFLPVDMQGVMLTVFCFIVF 3299
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQA----------ISMWALVISVTS 3719
+ + R + + ++ + V D+ ++M +++S+T+
Sbjct 3300 VTYSVRFFTCKQSWFSLAVTTILVIFNMVKIFGTSDEPWTENQIAFCFVNMLTMIVSLTT 3359
Query 3720 NYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNR 3779
VV +A IV + ++CI +VY GY CCY+G+ +NR
Sbjct 3360 KDWMVVIASYRIAYYIVVCVM--PSAFVSDFGFMKCISIVYMACGYLFCCYYGILYWVNR 3417
Query 3780 YFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKM 3839
+ +T GVY + VS E +YM + L PK++ DA L+ KL+G+GGK IK++TVQSK+
Sbjct 3418 FTCMTCGVYQFTVSAAELKYMTANNLSAPKNAYDAMILSAKLIGVGGKRNIKISTVQSKL 3477
Query 3840 SDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQ 3899
+++KCT+VVLL +L ++ VES+SK W CV LHN+I L D EK+++L++ LS
Sbjct 3478 TEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPEIVLEKLLALIAFFLSKH 3537
Query 3900 GAVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKK 3959
D++ L E +N LQ++AS +++LPS+ A A+ E+A N S +LK+L K
Sbjct 3538 NTCDLSELIESYFENTTILQSVASAYAALPSWIALEKARADLEEAKKNDVSPQILKQLTK 3597
Query 3960 SLNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDN 4019
+ N+AKS+F+R+A++Q+KL+KMA+QA MYK+AR+ D+++K+ SAM ++LF ML+KLD
Sbjct 3598 AFNIAKSDFEREASVQKKLDKMAEQAAASMYKEARAVDRKSKIVSAMHSLLFGMLKKLDM 3657
Query 4020 DALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVV 4079
++N II+ AR+G +PL+IIP +A +L+V+ P + N YA A+W I +V
Sbjct 3658 SSVNTIIDQARNGVLPLSIIPAASATRLVVITPSLEVFSKIRQENNVHYAGAIWTIVEVK 3717
Query 4080 DADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTA 4139
DA+ V L E+ N NL WPL +T R KLQNNE+ P L++ + A T
Sbjct 3718 DANGSHVHLKEVTAANELNLTWPLSITCER---TTKLQNNEIMPGKLKERAVRASATLDG 3774
Query 4140 CTDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKG 4199
+ A + G F+ A ++ +LK+ ++ + I ELE P RF D G
Sbjct 3775 EAFGSGKALMASESGKSFMYAFIASDNNLKYVKWESN--NDIIPIELEAPLRFYVDGANG 3832
Query 4200 PKVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKD 4259
P+VKYLYF+K LN L RG VLG + ATVRLQAG TE P+NS++L+ CAF+ DPAKAY D
Sbjct 3833 PEVKYLYFVKNLNTLRRGAVLGYIGATVRLQAGKPTEHPSNSSLLTLCAFSPDPAKAYVD 3892
Query 4260 YLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGF 4319
+ G QP+ NCVKML G G A+T EAN Q+S+GGAS C+YCRCH++HP G
Sbjct 3893 AVKRGMQPVNNCVKMLSNGAGNGMAVTNGVEANTQQDSYGGASVCIYCRCHVEHPAIDGL 3952
Query 4320 CDLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLN 4378
C KGK+VQIPT DP+ F + N VC VCG W GC CD R + ++LN
Sbjct 3953 CRYKGKFVQIPTG-TQDPIRFCIENEVCVVCGCWLNNGCMCD--RTSMQSFTVDQSYLN 4008
Score = 211 bits (537), Expect = 1e-52, Method: Composition-based stats.
Identities = 73/367 (20%), Positives = 117/367 (32%), Gaps = 32/367 (9%)
Query 1531 DKLKSLLSLREVKTIKVFTTVDNTNLHTQLVDMSMTYGQQF-GPTYLDGADVTKIKPHVN 1589
D+ + + +I V T DN N V TYG+Q G + DVT P
Sbjct 1475 DQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKTYGEQLKGTVVIKDKDVTNQLPSAF 1534
Query 1590 HEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADN 1649
G+ D F S Y K++ K DN
Sbjct 1535 DVGQKVIKAIDIDWQAHYGFRDAAAFSASSHDAY--------KFEVVTHSNFIVHKQTDN 1586
Query 1650 NCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETM 1709
NC+++++ LALQ+L+ ++ P ++ + F ++ S GE GD +
Sbjct 1587 NCWINAICLALQRLKPQWKFPGVRGLWNEFLERKTQGFVHMLYHISGVKKGEPGDAELML 1646
Query 1710 THLLQHANLESAKRVLN-VVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGR 1768
L + + V + C C K G + G CV G
Sbjct 1647 HKLGDLMDNDCEIIVTHTTACDKCA-KVEKFVGPVVAAPLAIH-------GTDETCVHGV 1698
Query 1769 DATQYLVQQESSFVMMS--APPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETL---- 1822
+ Q + + + S P L+ ++C Y+G+ + GHYT+ + L
Sbjct 1699 SVNVKVTQIKGTVAITSLIGPIIGEVLEATGYIC---YSGSNRNGHYTYYDNRNGLVVDA 1755
Query 1823 ---YRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYKLDGVTYTEIEPKLDGYYKK 1879
Y + L + V K + K+ E KL
Sbjct 1756 EKAYHFNRDLLQVTTAIASNF--VVKKPQAEERPKNCAFNKVAASPKIVQEQKLLAIESG 1813
Query 1880 DNAYYTE 1886
N TE
Sbjct 1814 ANYALTE 1820
Score = 209 bits (531), Expect = 7e-52, Method: Composition-based stats.
Identities = 89/395 (23%), Positives = 141/395 (36%), Gaps = 49/395 (12%)
Query 875 VVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENF--------SSRMYCSFY 926
+V E V L P+ + N G+ D V T G F +
Sbjct 1171 IVLERAVFKLTPLKESF-NYGVCGDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVK 1229
Query 927 PPDEEEEDDAECEEEEIDETCEHEYGTED----------------DYQGLPLEFGASAET 970
P + + EH Y + + +
Sbjct 1230 PVMHAVYTGTTQNGHYMVDDIEHGYCVDGMGIKPLKKRCYTSTLFINANVMTRAEKPKQE 1289
Query 971 VRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSA 1030
+VE+ E++ +++ E E P ++ + F KL+ +D++
Sbjct 1290 FKVEKVEQQPIVEENKSSIEKEEIQSPKNDDLILPFYKAGKLS--FYQGALDVL--INFL 1345
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAK 1090
P VIVNAAN LKH GGVA A++ T G + + S DY+K N + G +
Sbjct 1346 EPDVIVNAANGDLKHMGGVARAIDVFTGGKLTERSKDYLKKNKSIAPGNAVFFENVIEHL 1405
Query 1091 KCLHVVGPNLNAGEDIQLLKAAYENF-NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
L+ VGP L Y+ + +L PL+S GIF + SLQ ++TV
Sbjct 1406 SVLNAVGPRNGDSRVEAKLCNVYKAIAKCEGKILTPLISVGIFNVRLETSLQCLLKTV-- 1463
Query 1150 QVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP--NTEDSKTEEKSVVQKPVDVKPK 1207
ND+ L V Y D + +E P TED+ E+ V +
Sbjct 1464 ------NDRGLN---VFVYTDQERQTIENFFSCSIPVNVTEDNVNHERVSVSFDKTYGEQ 1514
Query 1208 IKACIDEVTTTLEETKFLTNKLLLFADINGKLYHD 1242
+K T + + K +TN+L D+ K+
Sbjct 1515 LKG------TVVIKDKDVTNQLPSAFDVGQKVIKA 1543
Score = 103 bits (257), Expect = 5e-20, Method: Composition-based stats.
Identities = 58/271 (21%), Positives = 93/271 (34%), Gaps = 24/271 (9%)
Query 1587 HVNHEGKTFFVLPSDDTLR-SEAFEYYHTLDESF----LGRYMSALNHTKKWKFPQVGGL 1641
E +T V T + E D + +K + G
Sbjct 1024 SSQEEVETVEVADITSTEEDVDIVEVSAKDDPWAAAVDVQEAEQFNPSLPPFKTTNLNGK 1083
Query 1642 TSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGE 1701
+K DNNC++++ LQ + FN EA+ + + GD +F L A + G
Sbjct 1084 IILKQGDNNCWINACCYQLQAFDF-FN----NEAWEKFKKGDVMDFVNLCYAATTLARGH 1138
Query 1702 LGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVS 1761
GD + +L + +AK VL C CG+K L E ++ T ++ GV
Sbjct 1139 SGDAEYLLELMLN--DYSTAKIVLAAKCG-CGEKEIVL---ERAVFKLTPLKESFNYGVC 1192
Query 1762 IPCVCGRDATQYLVQQESSFV---MMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITA 1818
C+ V+ FV + P + + YTG Q GHY
Sbjct 1193 GDCMQVNTCRFLSVEGSGVFVHDILSKQTPEAMFVVKPVMHA--VYTGTTQNGHYMVDDI 1250
Query 1819 KETLYRIDGAHLTKMSEYKGPVTDVFYKETS 1849
+ Y +DG + K T + +
Sbjct 1251 EHG-YCVDGMGIKP--LKKRCYTSTLFINAN 1278
Score = 72.4 bits (176), Expect = 1e-10, Method: Composition-based stats.
Identities = 74/378 (20%), Positives = 120/378 (32%), Gaps = 56/378 (15%)
Query 185 YVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAWFTER 244
YVD CG DG P+ + DY + E+ AW T R
Sbjct 113 YVDQYMCGADGKPV---------------IEGDFKDYFG-DEDIIEFEGEEYHCAWTTVR 156
Query 245 SDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRIRSVY 304
+K QT F I+ + + P N + + P V+K + +Y
Sbjct 157 DEKPLNQQTLFTIQEIQYNLDIPHKLP------NCATRHVAPPVKKNSKIVLSEDYKKLY 210
Query 305 PVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKAT-CEHCGTENLVIEGPTTCGYLPTN 363
++ S M C + T F+ AT CG+E+ + T
Sbjct 211 ---------DIFGSPFMGNGDCLSKCFDTLHFIAATLRCPCGSESSGVGDWTG------- 254
Query 364 AVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYW 423
K C G ++ D + T + G + F CV Y G + W
Sbjct 255 --FKTACCGLSGKVKGV--TLGDIKPGDAVVTSMSAGKGVKFFANCVLQYAGDVEGVSIW 310
Query 424 -VPRASADIGSGHT-GITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFS 481
V + + T G G+ + + + +++ I GD II
Sbjct 311 KVIKTFTVDETVCTPGFEGELNDFIKPESKSLVACSVKRAFITGDIDDAVHDCIITGKLD 370
Query 482 ASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAA 541
ST+ F + L +K V+ CG V AW + ++ + L Q
Sbjct 371 LSTNLFGNV--GLLFKKTPWFVQKCGALFV-------DAWKVVEE--LCGSLTLTYKQIY 419
Query 542 GVIRSIFARTLDAANHSI 559
V+ S+ N+
Sbjct 420 EVVASLCTSAFTIVNYKP 437
Score = 47.8 bits (112), Expect = 0.004, Method: Composition-based stats.
Identities = 63/343 (18%), Positives = 111/343 (32%), Gaps = 28/343 (8%)
Query 659 IVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNL-GEVFIAQSKGLY 717
++ ++V D K NK + + I G + FI + +Y
Sbjct 737 LIGNGVKVVCDGCKGFANQLSKGYNKLCNAARNDIEIGGIPFSTFKTPTNTFIEMTDAIY 796
Query 718 RQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGA 777
+GK L D + + E + +
Sbjct 797 SVIEQGKA----------------LSFRDADVPVVDNGTISTADWSEPILLEPAEYVKPK 840
Query 778 IVGTPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDT-VWEVQG 836
G + + G + +D+ Y G K G K V+F E+ V E+
Sbjct 841 NNGNVIVIAGYTFYKDEDEHFYPY---GFGKIVQRMYNKMGGGDKTVSFSEEVDVQEIAP 897
Query 837 YKNVRITFELD-ERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMG 895
V++ FE D E V VL +GT E++ + L + D L N G
Sbjct 898 VTRVKLEFEFDNEIVTGVLERAIGTRYKFTGTT----WEEFEESISEELDAIFDTLANQG 953
Query 896 IDLDE-WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTE 954
++L+ + T FD + Y +E+ + + EEE E+ E + E
Sbjct 954 VELEGYFIYDTCGGFDIKNPDGIMISQY-DINITADEKSEVSASSEEEEVESVEEDPENE 1012
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEP 997
E +S E V E + ++ + E+ + +P
Sbjct 1013 IVEASEGAEGTSSQEEVETVEVADITSTEEDVDIVEVSAKDDP 1055
>sp|B5F961|YMDB_SALA4 O-acetyl-ADP-ribose deacetylase OS=Salmonella
agona (strain SL483) OX=454166 GN=ymdB PE=3 SV=1
Length=179
Score = 164 bits (416), Expect = 9e-45, Method: Composition-based stats.
Identities = 53/176 (30%), Positives = 78/176 (44%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T + + DI + + IVNAAN L GGGV GA+++A A+ +
Sbjct 1 MTSRLQVIQGDITQ----LSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDIL 1122
G G + + L AK +H VGP GE + +LL+AAY N N +
Sbjct 57 QGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEYQEAELLEAAYRNCLLLAEANHFRSI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G Q+ +V V+TV + AL EQV D R+ A
Sbjct 117 AFPAISTGVYGYPRAQAAEVAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|B4T2X8|YMDB_SALNS O-acetyl-ADP-ribose deacetylase OS=Salmonella
newport (strain SL254) OX=423368 GN=ymdB PE=3 SV=1
Length=179
Score = 164 bits (416), Expect = 9e-45, Method: Composition-based stats.
Identities = 51/176 (29%), Positives = 77/176 (44%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T + + DI + + IVNAAN L GGGV GA+++A A+ +
Sbjct 1 MTSRLQVIQGDITQ----LSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDIL 1122
G G + + L AK +H VGP GE + +LL+ AY N N +
Sbjct 57 QGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRNCLLLAEANHFRSI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G Q+ ++ V+TV + AL EQV D R+ A
Sbjct 117 AFPAISTGVYGYPRAQAAEIAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|A7MG20|YMDB_CROS8 O-acetyl-ADP-ribose deacetylase OS=Cronobacter
sakazakii (strain ATCC BAA-894) OX=290339 GN=ymdB PE=3
SV=1
Length=180
Score = 164 bits (416), Expect = 1e-44, Method: Composition-based stats.
Identities = 50/184 (27%), Positives = 78/184 (42%), Gaps = 25/184 (14%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
++ + + DI + VIVNAAN L GGGV GA+++A A+ +
Sbjct 1 MSGRINVVQGDIT----LIDVDVIVNAANPSLMGGGGVDGAIHRAAGPALLAACRQVRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYEN------FNSQDIL 1122
G G + + +L AK +H VGP G + QLL AY N N + +
Sbjct 57 QGECQPGHAVITEAGDLAAKAVVHTVGPVWRGGQDNEPQLLADAYRNSLQLVAANGYNSV 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKA---LYEQVVMDYLD 1170
P +S GI+G + Q+ +TV QVY D+ LY++++ Y +
Sbjct 117 AFPAISTGIYGYPKAAAAQIAFETVSDYLTRHPQPKQVYFVCYDEENFLLYQRLLGQYDE 176
Query 1171 NLKP 1174
Sbjct 177 QPGA 180
>sp|P67341|YMDB_SALTY O-acetyl-ADP-ribose deacetylase OS=Salmonella
typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287
GN=ymdB PE=3 SV=1
Length=179
Score = 164 bits (415), Expect = 1e-44, Method: Composition-based stats.
Identities = 52/176 (30%), Positives = 77/176 (44%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T + + DI + + IVNAAN L GGGV GA+++A A+ +
Sbjct 1 MTSRLQVIQGDITQ----LSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDIL 1122
G G + + L AK +H VGP GE + +LL+ AY N N +
Sbjct 57 QGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRNCLLLAEANHFRSI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G Q+ +V V+TV + AL EQV D R+ A
Sbjct 117 AFPAISTGVYGYPRAQAAEVAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|P67342|YMDB_SALTI O-acetyl-ADP-ribose deacetylase OS=Salmonella
typhi OX=90370 GN=ymdB PE=3 SV=1
Length=179
Score = 164 bits (415), Expect = 1e-44, Method: Composition-based stats.
Identities = 52/176 (30%), Positives = 77/176 (44%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T + + DI + + IVNAAN L GGGV GA+++A A+ +
Sbjct 1 MTSRLQVIQGDITQ----LSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDIL 1122
G G + + L AK +H VGP GE + +LL+ AY N N +
Sbjct 57 QGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRNCLLLAEANHFRSI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G Q+ +V V+TV + AL EQV D R+ A
Sbjct 117 AFPAISTGVYGYPRAQAAEVAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|D5CE05|YMDB_ENTCC O-acetyl-ADP-ribose deacetylase OS=Enterobacter
cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054
/ NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56) OX=716541
GN=ymdB PE=3 SV=1
Length=180
Score = 164 bits (415), Expect = 1e-44, Method: Composition-based stats.
Identities = 43/170 (25%), Positives = 75/170 (44%), Gaps = 14/170 (8%)
Query 1019 KCVDIVK-EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+D++ + + + VIVNAAN L GGGV GA+++A + + + G
Sbjct 3 PQIDVIHGDITTMHVDVIVNAANPSLMGGGGVDGAIHRAAGPQLLEACKTVRQQQGECPP 62
Query 1078 GGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENF------NSQDILLAPLLS 1128
G + + +L AK +H VGP + G+ + +L+ AY N N + P +S
Sbjct 63 GHAVITLAGDLPAKAVIHAVGPIWHGGDRHEASILEEAYRNCLRLAADNGYKTMAFPAIS 122
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
G++G + + V T VY ++ K + E+V D +
Sbjct 123 TGVYGYPKAAAATIAVDT----VYRYLSLKPMPEKVTFVCFDEETLHLYQ 168
>sp|A4W960|YMDB_ENT38 O-acetyl-ADP-ribose deacetylase OS=Enterobacter
sp. (strain 638) OX=399742 GN=ymdB PE=3 SV=1
Length=180
Score = 163 bits (412), Expect = 3e-44, Method: Composition-based stats.
Identities = 46/176 (26%), Positives = 73/176 (41%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + + DI + VIVNAAN L GGGV GA+++A + + +
Sbjct 1 MKPQIEVVVGDIT----TMEVDVIVNAANPSLMGGGGVDGAIHRAAGPQLLEACKTVRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ--LLKAAYEN------FNSQDIL 1122
G G + + +L AK +H VGP GE+ + L+ AY N N L
Sbjct 57 QGECAPGHAVITIAGDLPAKAVIHAVGPVWQGGENHEARTLQDAYLNCLRLAAANGYKTL 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G + ++ V TV + K L E+V D ++
Sbjct 117 AFPAISTGVYGYPKAAAAEIAVDTVSE----FLTRKPLPERVYFVCYDEENAQLYQ 168
>sp|C9Y0V8|YMDB_CROTZ O-acetyl-ADP-ribose deacetylase OS=Cronobacter
turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827
/ z3032) OX=693216 GN=ymdB PE=3 SV=1
Length=176
Score = 163 bits (412), Expect = 4e-44, Method: Composition-based stats.
Identities = 49/180 (27%), Positives = 79/180 (44%), Gaps = 25/180 (14%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
++ + + DI + + VIVNAAN L GGGV GA+++A ++ +
Sbjct 1 MSGRINVVQGDITRI----DTDVIVNAANPSLMGGGGVDGAIHRAAGPSLLAACKVVRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYEN------FNSQDIL 1122
G G + + +L AK +H VGP G + QLL AY N N + +
Sbjct 57 QGECQPGHAVITEAGDLAAKAVIHTVGPIWRGGHDNEPQLLADAYRNSLELVTANGYNSV 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKA---LYEQVVMDYLD 1170
P +S GI+G + Q+ +TV QVY D+ LY++++ Y +
Sbjct 117 AFPAISTGIYGYPKAAAAQIAFETVSDYLTRRPQPKQVYFVCYDEENFLLYQRLLGQYDE 176
>sp|B5RBF3|YMDB_SALG2 O-acetyl-ADP-ribose deacetylase OS=Salmonella
gallinarum (strain 287/91 / NCTC 13346) OX=550538 GN=ymdB
PE=3 SV=1
Length=179
Score = 162 bits (411), Expect = 4e-44, Method: Composition-based stats.
Identities = 51/176 (29%), Positives = 77/176 (44%), Gaps = 17/176 (10%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+T + + DI + + IVNAAN L GGGV GA+++A A+ +
Sbjct 1 MTSRLQVIQGDITQ----LSVDAIVNAANASLMGGGGVDGAIHRAAGPALLDACKLIRQQ 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDIL 1122
G G + + L AK +H VGP GE + +LL+ AY + N +
Sbjct 57 QGECQTGHAVITPAGKLSAKAVIHTVGPVWRGGEHQEAELLEEAYRSCLLLAEANHFRSI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S G++G Q+ +V V+TV + AL EQV D R+ A
Sbjct 117 AFPAISTGVYGYPRAQAAEVAVRTVSD----FITRYALPEQVYFVCYDEETARLYA 168
>sp|B7LT90|YMDB_ESCF3 O-acetyl-ADP-ribose deacetylase OS=Escherichia
fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766
/ IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128
/ CDC 0568-73) OX=585054 GN=ymdB PE=3 SV=2
Length=177
Score = 162 bits (411), Expect = 4e-44, Method: Composition-based stats.
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 17/172 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI + A VIVNAAN L GGGV GA+++A + + + G
Sbjct 5 IHVLQGDITQLA----VDVIVNAANSSLMGGGGVDGAIHRAAGPELLEACQKVRRQQGEC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + NL A+ +H VGP GE + QLL AY N N + P
Sbjct 61 PTGHAVITIAGNLPARAVIHTVGPVWRDGEHNEDQLLHDAYLNSLKLAQANGYKSIAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+S G++G + ++ V+TV + AL EQ+ D R+
Sbjct 121 ISTGVYGFPRAAAAEIAVKTVSD----FITRHALPEQIYFVCYDEENSRLYN 168
>sp|P0A8D6|YMDB_ECOLI O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli (strain K12) OX=83333 GN=ymdB PE=1 SV=1
Length=177
Score = 162 bits (409), Expect = 7e-44, Method: Composition-based stats.
Identities = 52/171 (30%), Positives = 75/171 (44%), Gaps = 17/171 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K A VIVNAAN L GGGV GA+++A A+ + G
Sbjct 5 IHVVQGDITKLA----VDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + +L AK +H VGP GE + QLL+ AY N NS + P
Sbjct 61 PTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+S G++G + ++ V+TV + AL EQV D +
Sbjct 121 ISTGVYGYPRAAAAEIAVKTVSE----FITRHALPEQVYFVCYDEENAHLY 167
>sp|P0A8D7|YMDB_ECOL6 O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310
GN=ymdB PE=3 SV=1
Length=177
Score = 162 bits (409), Expect = 7e-44, Method: Composition-based stats.
Identities = 52/171 (30%), Positives = 75/171 (44%), Gaps = 17/171 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K A VIVNAAN L GGGV GA+++A A+ + G
Sbjct 5 IHVVQGDITKLA----VDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + +L AK +H VGP GE + QLL+ AY N NS + P
Sbjct 61 PTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+S G++G + ++ V+TV + AL EQV D +
Sbjct 121 ISTGVYGYPRAAAAEIAVKTVSE----FITRHALPEQVYFVCYDEENAHLY 167
>sp|P0A8D8|YMDB_ECO57 O-acetyl-ADP-ribose deacetylase OS=Escherichia
coli O157:H7 OX=83334 GN=ymdB PE=3 SV=1
Length=177
Score = 162 bits (409), Expect = 7e-44, Method: Composition-based stats.
Identities = 52/171 (30%), Positives = 75/171 (44%), Gaps = 17/171 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K A VIVNAAN L GGGV GA+++A A+ + G
Sbjct 5 IHVVQGDITKLA----VDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + +L AK +H VGP GE + QLL+ AY N NS + P
Sbjct 61 PTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+S G++G + ++ V+TV + AL EQV D +
Sbjct 121 ISTGVYGYPRAAAAEIAVKTVSE----FITRHALPEQVYFVCYDEENAHLY 167
>sp|D2TT52|YMDB_CITRI O-acetyl-ADP-ribose deacetylase OS=Citrobacter
rodentium (strain ICC168) OX=637910 GN=ymdB PE=3 SV=2
Length=177
Score = 161 bits (408), Expect = 1e-43, Method: Composition-based stats.
Identities = 43/162 (27%), Positives = 68/162 (42%), Gaps = 13/162 (8%)
Query 1026 EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
+ + IVNAAN L GGGV GA+++A + + + G G + + +
Sbjct 11 DITTVAVDAIVNAANPSLMGGGGVDGAIHRAAGPELLEACMTVRRQQGECPPGHAVITAA 70
Query 1086 HNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKP 1136
L AK +H VGP GE + QLL AY N N + P +S G++G
Sbjct 71 GRLPAKAVIHTVGPIWRGGEHNEAQLLHDAYLNSLNLALANGYQSIAFPAISTGVYGYPR 130
Query 1137 LQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+ ++ V T+ + +A EQ+ D R+
Sbjct 131 AAAAEIAVNTISE----FITRRASPEQIYFVCYDEETTRLYQ 168
>sp|Q0T5Z6|YMDB_SHIF8 O-acetyl-ADP-ribose deacetylase OS=Shigella
flexneri serotype 5b (strain 8401) OX=373384 GN=ymdB PE=3
SV=1
Length=177
Score = 161 bits (406), Expect = 2e-43, Method: Composition-based stats.
Identities = 51/171 (30%), Positives = 74/171 (43%), Gaps = 17/171 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K A VIVNAAN L GGGV GA+++A A+ + G
Sbjct 5 IHVVQGDITKLA----VDVIVNAANPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + +L AK +H VGP GE + QLL+ AY N NS + P
Sbjct 61 PTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+S G++ + ++ V+TV + AL EQV D +
Sbjct 121 ISTGVYSYPRAAAAEIAVKTVSE----FITRHALPEQVYFVCYDEENAHLY 167
>sp|D3RKJ0|YMDB_KLEVT O-acetyl-ADP-ribose deacetylase OS=Klebsiella
variicola (strain At-22) OX=640131 GN=ymdB PE=3 SV=1
Length=175
Score = 159 bits (403), Expect = 5e-43, Method: Composition-based stats.
Identities = 42/164 (26%), Positives = 73/164 (45%), Gaps = 13/164 (8%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL 1082
I+ + + VIVNAAN L GGGV GA+++A A+ ++ G G + +
Sbjct 8 ILGDITTLEVDVIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVI 67
Query 1083 LSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFG 1133
+L A +H VGP + G+ + Q L AY+N N+ + P +S G++G
Sbjct 68 TIAGDLPASAVIHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYG 127
Query 1134 AKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
++ ++ V+TV + E+V+ D +
Sbjct 128 YPKEEAAEIAVRTVTA----FLTRYNPLERVLFVCFDEETAAIY 167
>sp|B5XXK9|YMDB_KLEP3 O-acetyl-ADP-ribose deacetylase OS=Klebsiella
pneumoniae (strain 342) OX=507522 GN=ymdB PE=3 SV=1
Length=175
Score = 159 bits (403), Expect = 5e-43, Method: Composition-based stats.
Identities = 42/164 (26%), Positives = 73/164 (45%), Gaps = 13/164 (8%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL 1082
I+ + + VIVNAAN L GGGV GA+++A A+ ++ G G + +
Sbjct 8 ILGDITTLEVDVIVNAANPSLLGGGGVDGAIHRAAGPALLAACKQVLQQQGECPPGHAVI 67
Query 1083 LSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPLLSAGIFG 1133
+L A +H VGP + G+ + Q L AY+N N+ + P +S G++G
Sbjct 68 TIAGDLPASAVIHTVGPVWHGGDRMEAQTLADAYKNSLQLAAANNYRSIAFPAISTGVYG 127
Query 1134 AKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
++ ++ V+TV + E+V+ D +
Sbjct 128 YPKEEAAEIAVRTVTA----FLTRYNPLERVLFVCFDEETAAIY 167
>sp|A8AI35|YMDB_CITK8 O-acetyl-ADP-ribose deacetylase OS=Citrobacter
koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
OX=290338 GN=ymdB PE=3 SV=1
Length=177
Score = 159 bits (403), Expect = 5e-43, Method: Composition-based stats.
Identities = 49/166 (30%), Positives = 69/166 (42%), Gaps = 17/166 (10%)
Query 1021 VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS 1080
DI + VIVNAAN L GGGV GA+++A + + + G G +
Sbjct 10 GDITQ----LTVDVIVNAANASLLGGGGVDGAIHRAAGPTLLEACKKVRQQQGECPAGHA 65
Query 1081 CLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYEN------FNSQDILLAPLLSAGI 1131
+ NL AK +H VGP G + QLL+ AY N N + P +S G
Sbjct 66 VITLAGNLPAKAVIHTVGPVWRGGDHNESQLLEDAYFNSLQLVLANGYRSVAFPAISTGA 125
Query 1132 FGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+G + ++ V TV + AL EQV D R+
Sbjct 126 YGYPRPAAAEIAVNTVAD----FLARHALPEQVYFVCYDEETARLY 167
>sp|Q32E73|YMDB_SHIDS O-acetyl-ADP-ribose deacetylase OS=Shigella
dysenteriae serotype 1 (strain Sd197) OX=300267 GN=ymdB
PE=3 SV=1
Length=177
Score = 156 bits (394), Expect = 9e-42, Method: Composition-based stats.
Identities = 50/171 (29%), Positives = 73/171 (43%), Gaps = 17/171 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K A VIVN N L GGGV GA+++A A+ + G
Sbjct 5 IHVVQGDITKLA----VDVIVNVTNPSLMGGGGVDGAIHRAAGPALLDACLKVRQQQGDC 60
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G + + +L AK +H VGP GE + QLL+ AY N NS + P
Sbjct 61 PTGHAVITLAGDLPAKAVVHTVGPVWRGGEQNEDQLLQDAYLNSLRLVAANSYTSVAFPA 120
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+S G++G + ++ V+TV + AL EQV D +
Sbjct 121 ISTGVYGYPRAAAAEIAVKTVSE----FITRHALPEQVYFVCYDEENAHLY 167
>sp|Q8EYT0|Y4133_LEPIN Macro domain-containing protein LA_4133
OS=Leptospira interrogans serogroup Icterohaemorrhagiae serovar
Lai (strain 56601) OX=189518 GN=LA_4133 PE=4 SV=1
Length=175
Score = 148 bits (373), Expect = 5e-39, Method: Composition-based stats.
Identities = 43/167 (26%), Positives = 74/167 (44%), Gaps = 21/167 (13%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL 1082
I ++ IVNAAN L GGGV GA+++A + +E + G VG + +
Sbjct 8 IKEDITQLEVDAIVNAANSSLLGGGGVDGAIHRAGGPEILEECYKIREKQGECKVGEAVI 67
Query 1083 LSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENF------NSQDILLAPLLSAGIFG 1133
+ L AK +H VGP + G + +LL AY+N +S + P +S GI+
Sbjct 68 TTAGRLNAKFIIHTVGPIWSGGNKNEDELLSNAYKNSLLLAKNHSLKTIAFPNISTGIYH 127
Query 1134 AKPLQSLQVCVQTVRT---------QVYIAVND---KALYEQVVMDY 1168
++ ++ +Q+V V+ D +Y +++ Y
Sbjct 128 FPKERAAKIAIQSVTEFLKQDNQIQTVFFVCFDFENLEIYNKLLQTY 174
>sp|Q72M93|Y3295_LEPIC Macro domain-containing protein LIC_13295
OS=Leptospira interrogans serogroup Icterohaemorrhagiae serovar
copenhageni (strain Fiocruz L1-130) OX=267671 GN=LIC_13295
PE=4 SV=1
Length=175
Score = 148 bits (373), Expect = 5e-39, Method: Composition-based stats.
Identities = 43/167 (26%), Positives = 74/167 (44%), Gaps = 21/167 (13%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL 1082
I ++ IVNAAN L GGGV GA+++A + +E + G VG + +
Sbjct 8 IKEDITQLEVDAIVNAANSSLLGGGGVDGAIHRAGGPEILEECYKIREKQGECKVGEAVI 67
Query 1083 LSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENF------NSQDILLAPLLSAGIFG 1133
+ L AK +H VGP + G + +LL AY+N +S + P +S GI+
Sbjct 68 TTAGRLNAKFIIHTVGPIWSGGNKNEDELLSNAYKNSLLLAKNHSLKTIAFPNISTGIYH 127
Query 1134 AKPLQSLQVCVQTVRT---------QVYIAVND---KALYEQVVMDY 1168
++ ++ +Q+V V+ D +Y +++ Y
Sbjct 128 FPKERAAKIAIQSVTKFLKQDNQIQTVFFVCFDFENLEIYNKLLQTY 174
>sp|E1SDF1|YMDB1_PANVC O-acetyl-ADP-ribose deacetylase 1 OS=Pantoea
vagans (strain C9-1) OX=712898 GN=ymdB1 PE=3 SV=1
Length=171
Score = 143 bits (361), Expect = 2e-37, Method: Composition-based stats.
Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 22/165 (13%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K + A IVNAAN L GGGV GA+++A + E G
Sbjct 4 ITVIQGDITKVSAEA----IVNAANSSLLGGGGVDGAIHRAGGPVILAECQLIRNRQGGC 59
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYEN------FNSQDILLAPL 1126
VG + + NL A +H VGP + G ++ LLK AY++ ++ + P
Sbjct 60 KVGDAVITGAGNLPADYVIHTVGPRWSDGRHDEDALLKRAYQSCFKLVDYHGIKTVSFPN 119
Query 1127 LSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKALYE 1162
+S GI+G ++ + + ++ V + D Y+
Sbjct 120 ISTGIYGFPKERAATIALDVIKHCIAENRTLENVNLVCFDAENYD 164
>sp|Q8KAE4|Y2219_CHLTE Macro domain-containing protein CT2219
OS=Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC
103806 / TLS) OX=194439 GN=CT2219 PE=4 SV=1
Length=172
Score = 141 bits (356), Expect = 1e-36, Method: Composition-based stats.
Identities = 47/176 (27%), Positives = 75/176 (43%), Gaps = 19/176 (11%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ DNV I I + S IVNAAN L GGGV GA+++A + + +
Sbjct 1 MPDNVLIHA--IKADITSLTVDAIVNAANTSLLGGGGVDGAIHRAAGPKLLEACREL--- 55
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENF------NSQDIL 1122
G G + + G+ L A +H VGP + G + +LL + Y N + +
Sbjct 56 -GGCLTGEAKITKGYRLPATFVIHTVGPVWHGGNHGEAELLASCYRNSLKLAIEHHCRTI 114
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
P +S GI+G Q+ + + TVR + D+ E+V+ + V
Sbjct 115 AFPSISTGIYGYPVEQAAAIAITTVRE----MLADERGIEKVIFCCFSDRDLDVYQ 166
>sp|Q4J9D2|Y1252_SULAC Uncharacterized protein Saci_1252 OS=Sulfolobus
acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929
/ NBRC 15157 / NCIMB 11770) OX=330779 GN=Saci_1252 PE=4
SV=1
Length=181
Score = 139 bits (351), Expect = 6e-36, Method: Composition-based stats.
Identities = 48/179 (27%), Positives = 77/179 (43%), Gaps = 15/179 (8%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
V ++ DI K IVNAAN +L HGGGVA A+ ++ +Q+ESD+Y++ NGP
Sbjct 12 EVILENGDITKVE----ADAIVNAANSYLSHGGGVALAIVRSGGYIIQEESDEYVRRNGP 67
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQD-----ILLAPLLS 1128
+ VG + + L A+ +H VGP D +L A + D + P +S
Sbjct 68 VPVGEVAVTTAGKLKARYVIHAVGPRYGIEGDDKLESAIRRSLEKADELKLSSIALPAIS 127
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNT 1187
GI+G ++ + ++ K L +V+ Y D +
Sbjct 128 TGIYGYPYEICARIMSKVMKE-----YKPKFLKRILVVVYGDQAYSVFKKVFDNSLYMN 181
>sp|P0C6F3|R1A_BEV Replicase polyprotein 1a OS=Berne virus OX=11156
GN=1a PE=1 SV=1
Length=4569
Score = 155 bits (391), Expect = 1e-35, Method: Composition-based stats.
Identities = 56/220 (25%), Positives = 91/220 (41%), Gaps = 16/220 (7%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQF---TGYLKLTDNVAI 1018
L+ G+ E V V+ + +++ + E+ E + P E +F + L +
Sbjct 1641 LDIGSQCERVFVDYDVKKNEWTLSPEEGEDSDDNLDLPFEQYYEFKIGQTNVVLVQDDFK 1700
Query 1019 KCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVG 1078
+ +K Q +VN AN LKHGGG+A ++ +Q S++YI N + V
Sbjct 1701 SVFEFLKSEQGV--DYVVNPANSQLKHGGGIAKVISCMCGPKLQAWSNNYITKNKTVPVT 1758
Query 1079 GSCLLSGHNLAKKC--LHVVGPNLNAGEDIQLLKAAYENF----NSQDILLAPLLSAGIF 1132
+ G L KK +H VGP ++ G+ Q L A+ + Q +L +LS GIF
Sbjct 1759 KAIKSPGFQLGKKVNIIHAVGPRVSDGDVFQKLDQAWRSVFDLCEDQHTILTSMLSTGIF 1818
Query 1133 GAKPLQSLQVCVQTVRTQ-----VYIAVNDKALYEQVVMD 1167
G S + V V++ N Y Q
Sbjct 1819 GCTVNDSFNTFLSNVARLDKSLVVFVVTNMVEQYNQAFAV 1858
Score = 54.3 bits (129), Expect = 3e-05, Method: Composition-based stats.
Identities = 59/259 (23%), Positives = 101/259 (39%), Gaps = 43/259 (17%)
Query 2994 VFCGVDAMNLI--ANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEY 3051
G +++ + I +P V + V +V+ +I + + +Y F +
Sbjct 3042 YTTGSNSVECLPTFEIISPYV--FVFIVVIFTVIFLILIRLYIVMYSY--------FKVF 3091
Query 3052 NHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSP 3111
+VV LLF+ +L +V +PGV V L+L + V FL +L + ++F
Sbjct 3092 TYVVFK--LLFVNIIMVLFVVCLPPLVPGVVFVLALWLC----DSVMFLLYLAFLSLF-- 3143
Query 3112 IVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKL 3170
I+P++ ++F + W + + +G+TF TFE+ + C F LN +
Sbjct 3144 ILPWFYVLFFLFMVGGFVFWWMMRSADVVHLTTDGLTFNGTFEQISKCVFPLNP----LI 3199
Query 3171 RSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPP 3230
+ LL + L +K K G LA + +G YQP
Sbjct 3200 VNRMLLDCQMSHSDLVEKSKLKTTEGK-------------LANEMMKVFMTGETSYYQPS 3246
Query 3231 QTSITSAVLQSGFRKMAFP 3249
S QS F K P
Sbjct 3247 NFSF-----QSVFSKATSP 3260
>sp|P0C6V7|R1AB_BEV Replicase polyprotein 1ab OS=Berne virus OX=11156
GN=rep PE=1 SV=1
Length=6857
Score = 154 bits (390), Expect = 2e-35, Method: Composition-based stats.
Identities = 56/220 (25%), Positives = 91/220 (41%), Gaps = 16/220 (7%)
Query 962 LEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQF---TGYLKLTDNVAI 1018
L+ G+ E V V+ + +++ + E+ E + P E +F + L +
Sbjct 1641 LDIGSQCERVFVDYDVKKNEWTLSPEEGEDSDDNLDLPFEQYYEFKIGQTNVVLVQDDFK 1700
Query 1019 KCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVG 1078
+ +K Q +VN AN LKHGGG+A ++ +Q S++YI N + V
Sbjct 1701 SVFEFLKSEQGV--DYVVNPANSQLKHGGGIAKVISCMCGPKLQAWSNNYITKNKTVPVT 1758
Query 1079 GSCLLSGHNLAKKC--LHVVGPNLNAGEDIQLLKAAYENF----NSQDILLAPLLSAGIF 1132
+ G L KK +H VGP ++ G+ Q L A+ + Q +L +LS GIF
Sbjct 1759 KAIKSPGFQLGKKVNIIHAVGPRVSDGDVFQKLDQAWRSVFDLCEDQHTILTSMLSTGIF 1818
Query 1133 GAKPLQSLQVCVQTVRTQ-----VYIAVNDKALYEQVVMD 1167
G S + V V++ N Y Q
Sbjct 1819 GCTVNDSFNTFLSNVARLDKSLVVFVVTNMVEQYNQAFAV 1858
Score = 53.9 bits (128), Expect = 4e-05, Method: Composition-based stats.
Identities = 59/259 (23%), Positives = 101/259 (39%), Gaps = 43/259 (17%)
Query 2994 VFCGVDAMNLI--ANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEY 3051
G +++ + I +P V + V +V+ +I + + +Y F +
Sbjct 3042 YTTGSNSVECLPTFEIISPYV--FVFIVVIFTVIFLILIRLYIVMYSY--------FKVF 3091
Query 3052 NHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSP 3111
+VV LLF+ +L +V +PGV V L+L + V FL +L + ++F
Sbjct 3092 TYVVFK--LLFVNIIMVLFVVCLPPLVPGVVFVLALWLC----DSVMFLLYLAFLSLF-- 3143
Query 3112 IVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF-STFEEAALCTFLLNKEMYLKL 3170
I+P++ ++F + W + + +G+TF TFE+ + C F LN +
Sbjct 3144 ILPWFYVLFFLFMVGGFVFWWMMRSADVVHLTTDGLTFNGTFEQISKCVFPLNP----LI 3199
Query 3171 RSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPP 3230
+ LL + L +K K G LA + +G YQP
Sbjct 3200 VNRMLLDCQMSHSDLVEKSKLKTTEGK-------------LANEMMKVFMTGETSYYQPS 3246
Query 3231 QTSITSAVLQSGFRKMAFP 3249
S QS F K P
Sbjct 3247 NFSF-----QSVFSKATSP 3260
>sp|Q96XY5|Y2383_SULTO Uncharacterized protein STK_23830 OS=Sulfurisphaera
tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140
/ 7) OX=273063 GN=STK_23830 PE=4 SV=1
Length=182
Score = 137 bits (346), Expect = 3e-35, Method: Composition-based stats.
Identities = 52/188 (28%), Positives = 81/188 (43%), Gaps = 15/188 (8%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
V I DI + A IVNAAN +L+HGGGVA A+ + +QKES +Y++ GP+
Sbjct 3 VKIIKGDITEIEAEA----IVNAANSYLEHGGGVARAIVEKGGYIIQKESREYVRKYGPV 58
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQ------DILLAPLLS 1128
GG + S L AK +H VGP E + L+ A N + + P +S
Sbjct 59 PTGGVAVTSAGKLKAKYVIHAVGPRYGI-EGEEKLEEAIRNALRKAEELKLSSIALPAIS 117
Query 1129 AGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTE 1188
GI+G + V+ ++ + N K L +V Y + + E +
Sbjct 118 TGIYGYPYEICAEKMVKVIKEE---YTNFKHLNTIIVSLYSEEAYNIFVNIFERELAKEK 174
Query 1189 DSKTEEKS 1196
+ +
Sbjct 175 NITLKMSP 182
>sp|Q8ZXT3|Y1111_PYRAE Uncharacterized protein PAE1111 OS=Pyrobaculum
aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630
/ CIP 104966 / NBRC 100827 / IM2) OX=178306 GN=PAE1111 PE=4
SV=1
Length=182
Score = 137 bits (344), Expect = 5e-35, Method: Composition-based stats.
Identities = 49/178 (28%), Positives = 83/178 (47%), Gaps = 15/178 (8%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
V + DI + IVNAAN +L+HGGGVAGA+ + +Q+ES ++++ +GP
Sbjct 9 EVVLMRGDITEVE----ADAIVNAANSYLEHGGGVAGAIVRKGGQVIQEESREWVRKHGP 64
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQD------ILLAPLL 1127
+ VG + S L AK +H VGP E I+ L A +N + + P +
Sbjct 65 VPVGDVAVTSAGRLKAKYVIHAVGPRC-GVEPIEKLAEAVKNALLKAEELGLVSIALPAI 123
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP 1185
S GIFG + + +R +A +++ +V+ Y + + ++ P
Sbjct 124 STGIFGCPYDAAAEQMATAIRE---VAPALRSIRRILVVLYGEEAYQKFLEVFKKHLP 178
>sp|Q97UU4|Y2899_SACS2 Uncharacterized protein SSO2899 OS=Saccharolobus
solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322
/ P2) OX=273057 GN=SSO2899 PE=4 SV=1
Length=177
Score = 136 bits (342), Expect = 8e-35, Method: Composition-based stats.
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 17/172 (10%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + DI + IVNAAN +L+HGGGVA A+ + +QKESD+Y+K GP
Sbjct 9 EIYLIKGDITEIE----ADAIVNAANSYLQHGGGVAYAIVRKGGYIIQKESDEYVKKFGP 64
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQD-----ILLAPLLS 1128
+ VG + S L AK +H VGP + +L A +++ D + P +S
Sbjct 65 VPVGEVAVTSAGKLKAKYVIHAVGPRYGIEGEDKLESAIFKSLLKADELSLSSIAMPAIS 124
Query 1129 AGIFGAKPLQSLQVCVQTVR-------TQVYIAVNDKALYEQVVMDYLDNLK 1173
GI+G ++ ++ +V I + K Y+ + LK
Sbjct 125 TGIYGYPFEICARIMANVLKGYKPKTLRKVMICLYTKDAYDVFKSIFNSILK 176
>sp|Q9WYX8|Y508_THEMA Uncharacterized protein TM_0508 OS=Thermotoga
maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC
100826 / MSB8) OX=243274 GN=TM_0508 PE=3 SV=1
Length=599
Score = 145 bits (366), Expect = 4e-34, Method: Composition-based stats.
Identities = 53/174 (30%), Positives = 82/174 (47%), Gaps = 15/174 (9%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ I DI +E IVNAAN +LKHGGGVAGA+ +A +Q+ESD ++ G +
Sbjct 429 IRIVKGDITREE----VDAIVNAANEYLKHGGGVAGAIVRAGGSVIQEESDRIVQERGRV 484
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNA---GEDIQLLKAAYENF-----NSQDILLAPL 1126
G + + S L AK +H VGP GED L KA Y + P
Sbjct 485 PTGEAVVTSAGKLKAKYVIHTVGPVWRGGSHGEDELLYKAVYNALLRAHELKLKSISMPA 544
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPK 1180
+S GIFG +++ + + +R +I + E++ + +D ++ K
Sbjct 545 ISTGIFGFPKERAVGIFSKAIRD--FIDQHPDTTLEEIRICNIDEETTKIFEEK 596
>sp|Q8RB30|Y995_CALS4 Macro domain-containing protein TTE0995
OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain
DSM 15242 / JCM 11007 / NBRC 100824 / MB4) OX=273068 GN=TTE0995
PE=4 SV=1
Length=175
Score = 134 bits (336), Expect = 6e-34, Method: Composition-based stats.
Identities = 39/147 (27%), Positives = 64/147 (44%), Gaps = 13/147 (9%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + + + +IV + IVNAAN L GGGV GA++KA A+ +E +
Sbjct 1 MKEKIKLIKGNIVDQE----VDAIVNAANSSLIGGGGVDGAIHKAGGPAIAEELKVIREK 56
Query 1072 NGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENFNSQ------DIL 1122
G G + + NL AK +H VGP G + LL +AY +
Sbjct 57 QGGCPTGHAVITGAGNLKAKYVIHAVGPIWKGGNHNEDNLLASAYIESLKLADEYNVKTI 116
Query 1123 LAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
P +S G +G ++ ++ ++ V
Sbjct 117 AFPSISTGAYGFPVERAARIALRVVSD 143
>sp|P0C6F4|R1A_BRV1 Replicase polyprotein 1a OS=Breda virus 1
OX=360393 GN=1a PE=3 SV=1
Length=4445
Score = 148 bits (373), Expect = 2e-33, Method: Composition-based stats.
Identities = 53/204 (26%), Positives = 88/204 (43%), Gaps = 17/204 (8%)
Query 956 DYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGY------ 1009
D + L+ G+S E V V+ + ++ D +T ++ + E P NQ+ +
Sbjct 1589 DGECESLDVGSSLEQVYVDYDVSKNVWDLSTH---LQDDSSDDLELPFNQYYEFKVGRAS 1645
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
+ L + D +K Q +VN AN LKHGGG+A ++ + S++YI
Sbjct 1646 VVLVQDDFKSVYDFLKSEQGV--DYVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYI 1703
Query 1070 KLNGPLTVGGSCLLSGHNLAK--KCLHVVGPNLNAGEDIQLLKA----AYENFNSQDILL 1123
K L V + G L K + +HVVGP + + L+A ++N +L
Sbjct 1704 KQYKKLGVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVL 1763
Query 1124 APLLSAGIFGAKPLQSLQVCVQTV 1147
+LS GIFG S + +
Sbjct 1764 TSMLSTGIFGCSVTDSATTLLSNL 1787
Score = 56.3 bits (134), Expect = 1e-05, Method: Composition-based stats.
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (14%)
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
VV I I+ ++ F + +VV LLF+ + +L +V +PGV
Sbjct 2944 VVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFK--LLFVNTVMVLFVVCLPPLVPGVVF 3001
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVM 3143
V L+L + V FL +L ++F I+P++ ++V + W + +
Sbjct 3002 VLALWLC----DSVVFLLYLAVLSLF--ILPWFYVMLFVLIVGGFVFWWMMKSSDVVHLT 3055
Query 3144 FNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
+G+TF TFE+ + C F LN + + LL + L +K K G
Sbjct 3056 PDGLTFNGTFEQVSKCVFPLNP----LIVNRLLLDCRMSHSDLVEKSKLKTTEGK----- 3106
Query 3203 YREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFP 3249
LA + +G YQP S QS F K+ P
Sbjct 3107 --------LATEMMKVFMTGETAYYQPSNFSF-----QSVFSKVVSP 3140
>sp|Q8Q0F9|Y177_METMA Macro domain-containing protein MM_0177
OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1
/ Go1 / JCM 11833 / OCM 88) OX=192952 GN=MM_0177 PE=4 SV=1
Length=187
Score = 132 bits (333), Expect = 2e-33, Method: Composition-based stats.
Identities = 49/164 (30%), Positives = 71/164 (43%), Gaps = 26/164 (16%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
D + I DIVK IVNAAN L GGGV GA+++A A+ +E LNG
Sbjct 19 DRIRIFEGDIVK----MRVDAIVNAANNTLLGGGGVDGAIHRAAGPALLEECKT---LNG 71
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENFNSQ------DILLA 1124
G + + SG+ L AK +H VGP GE + +LL + Y +
Sbjct 72 -CPTGEAKITSGYLLPAKYIIHTVGPVWQGGEKGEDELLASCYRKSLELARDYKIKTIAF 130
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKA 1159
P +S G +G ++ + V V+ VY+ +K
Sbjct 131 PAISTGAYGFPSERAAGIAVSQVKEFLQKNEIPETVYLVCYNKD 174
>sp|P0C6V8|R1AB_BRV1 Replicase polyprotein 1ab OS=Breda virus
1 OX=360393 GN=rep PE=2 SV=1
Length=6733
Score = 147 bits (372), Expect = 2e-33, Method: Composition-based stats.
Identities = 53/204 (26%), Positives = 88/204 (43%), Gaps = 17/204 (8%)
Query 956 DYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGY------ 1009
D + L+ G+S E V V+ + ++ D +T ++ + E P NQ+ +
Sbjct 1589 DGECESLDVGSSLEQVYVDYDVSKNVWDLSTH---LQDDSSDDLELPFNQYYEFKVGRAS 1645
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
+ L + D +K Q +VN AN LKHGGG+A ++ + S++YI
Sbjct 1646 VVLVQDDFKSVYDFLKSEQGV--DYVVNPANNQLKHGGGIAKVISCMCGPKLTSWSNNYI 1703
Query 1070 KLNGPLTVGGSCLLSGHNLAK--KCLHVVGPNLNAGEDIQLLKA----AYENFNSQDILL 1123
K L V + G L K + +HVVGP + + L+A ++N +L
Sbjct 1704 KQYKKLGVTCAIRSPGFQLGKGVQIIHVVGPKSADSDVVNKLEASWRSVFQNVKPDTTVL 1763
Query 1124 APLLSAGIFGAKPLQSLQVCVQTV 1147
+LS GIFG S + +
Sbjct 1764 TSMLSTGIFGCSVTDSATTLLSNL 1787
Score = 56.3 bits (134), Expect = 1e-05, Method: Composition-based stats.
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (14%)
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
VV I I+ ++ F + +VV LLF+ + +L +V +PGV
Sbjct 2944 VVLVAIFTIVFLFLLRMYIVMYSYFKVFTYVVFK--LLFVNTVMVLFVVCLPPLVPGVVF 3001
Query 3084 VFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVM 3143
V L+L + V FL +L ++F I+P++ ++V + W + +
Sbjct 3002 VLALWLC----DSVVFLLYLAVLSLF--ILPWFYVMLFVLIVGGFVFWWMMKSSDVVHLT 3055
Query 3144 FNGVTF-STFEEAALCTFLLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTS 3202
+G+TF TFE+ + C F LN + + LL + L +K K G
Sbjct 3056 PDGLTFNGTFEQVSKCVFPLNP----LIVNRLLLDCRMSHSDLVEKSKLKTTEGK----- 3106
Query 3203 YREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQSGFRKMAFP 3249
LA + +G YQP S QS F K+ P
Sbjct 3107 --------LATEMMKVFMTGETAYYQPSNFSF-----QSVFSKVVSP 3140
>sp|E1PL40|YMDB2_PANVC O-acetyl-ADP-ribose deacetylase 2 OS=Pantoea
vagans (strain C9-1) OX=712898 GN=ymdB2 PE=3 SV=1
Length=171
Score = 130 bits (328), Expect = 5e-33, Method: Composition-based stats.
Identities = 38/167 (23%), Positives = 66/167 (40%), Gaps = 22/167 (13%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
+ + + DI A A I+N AN L GGGV GA+++A + E G
Sbjct 2 NKITVIQGDITNIASEA----IINVANSSLLGGGGVDGAIHRAGGPVILAECQAIRSRQG 57
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENF------NSQDILLA 1124
VG + + L A +H VGP + G + LK+ Y + + +
Sbjct 58 GCKVGEAVITGAGTLPADYVIHTVGPRWSDGRHNEDTQLKSVYLSCFKLVGHHGIKTVSF 117
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKALYE 1162
P +S GI+G ++ + + ++ +V + D Y+
Sbjct 118 PNISTGIYGFPKKRAAAIALDVIKHCIAENRTIEKVNLVCFDAENYD 164
>sp|Q8Y2K1|Y334_RALN1 Macro domain-containing protein RSc0334
OS=Ralstonia nicotianae (strain GMI1000) OX=267608 GN=RSc0334
PE=4 SV=1
Length=171
Score = 129 bits (324), Expect = 2e-32, Method: Composition-based stats.
Identities = 39/133 (29%), Positives = 61/133 (46%), Gaps = 13/133 (10%)
Query 1026 EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
+ + IVNAAN L GGGV GA+++A + + L+G G + + G
Sbjct 14 DITTLACDAIVNAANSALLGGGGVDGAIHRAAGPELLEAC---RALHG-CRTGQAKITPG 69
Query 1086 HNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKP 1136
L A+ +H VGP G ++ LL A Y N + + P +S G++G P
Sbjct 70 FLLPARYIIHTVGPIWRGGRQDEAALLAACYRNSLALAKQHDVRTIAFPCISTGVYGFPP 129
Query 1137 LQSLQVCVQTVRT 1149
+ + V+TVR
Sbjct 130 QLAAPIAVRTVRE 142
>sp|Q87JZ5|Y4103_VIBPA Macro domain-containing protein VPA0103
OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
OX=223926 GN=VPA0103 PE=4 SV=1
Length=170
Score = 125 bits (314), Expect = 4e-31, Method: Composition-based stats.
Identities = 39/152 (26%), Positives = 73/152 (48%), Gaps = 13/152 (9%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG-P 1074
+++ DI +A+ IVNAAN + GGGV GA+++A A+ ++G
Sbjct 4 ISLVQGDIT----TAHVDAIVNAANPRMLGGGGVDGAIHRAAGPALINACYAVDDVDGIR 59
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-LLKAAYEN------FNSQDILLAPL 1126
G + + NL A+ +H VGP + D + +L++AY+ N + P
Sbjct 60 CPFGDARITEAGNLNARYVIHAVGPIYDKFADPKTVLESAYQRSLDLALANHCQSVALPA 119
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDK 1158
+S G++G P ++ +V + + Y A++ +
Sbjct 120 ISCGVYGYPPQEAAEVAMAVCQRPEYAALDMR 151
>sp|Q7MTZ7|MACRO_PORGI Macro domain-containing protein PG1779
OS=Porphyromonas gingivalis (strain ATCC BAA-308 / W83) OX=242619
GN=PG_1779 PE=2 SV=1
Length=164
Score = 124 bits (312), Expect = 7e-31, Method: Composition-based stats.
Identities = 44/163 (27%), Positives = 70/163 (43%), Gaps = 24/163 (15%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ I DI + IVNAAN L GGGV GA+++A + +E LNG
Sbjct 4 ITITVGDITR----FEGDAIVNAANHTLLGGGGVDGAIHRAAGPELLEECRT---LNG-C 55
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN------FNSQDILLAPL 1126
G S + G+NL A+ +H VGP + G+ + +LL + Y + P
Sbjct 56 PTGESKITGGYNLPAQYVIHTVGPVWHGGQHGEPELLASCYRTSLSIALDKGLKSIAFPC 115
Query 1127 LSAGIFGAKPLQSLQVCVQTVRT-------QVYIAVNDKALYE 1162
+S G++ Q+ ++ + T+ V I +A E
Sbjct 116 ISTGVYRYPKDQAARIALATIGEIIADRPIDVTIVCFSEADKE 158
>sp|Q926Y8|Y2902_LISIN Macro domain-containing protein lin2902
OS=Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP
11262) OX=272626 GN=lin2902 PE=4 SV=1
Length=176
Score = 124 bits (312), Expect = 9e-31, Method: Composition-based stats.
Identities = 44/173 (25%), Positives = 71/173 (41%), Gaps = 15/173 (9%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
++ + DI ++ N VIVNAAN L GGGV GA+++A + KE + I G
Sbjct 2 DITVVKGDITEQ----NVDVIVNAANPGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGS 57
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAY------ENFNSQDILLAP 1125
G + + S +L A +H VGP GE + L + Y + P
Sbjct 58 CPAGEAVITSAGDLKAHFIIHAVGPIWKDGEHQEANKLASCYWKALDLAAGKDLTSIAFP 117
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+S G++G + +V + TVR + ++V D +
Sbjct 118 NISTGVYGFPKKLAAEVALYTVRKWAEEEYDSS--IKEVRFVCFDEENLTLYN 168
>sp|Q71W03|Y2748_LISMF Macro domain-containing protein LMOf2365_2748
OS=Listeria monocytogenes serotype 4b (strain F2365)
OX=265669 GN=LMOf2365_2748 PE=4 SV=1
Length=176
Score = 124 bits (311), Expect = 1e-30, Method: Composition-based stats.
Identities = 43/173 (25%), Positives = 71/173 (41%), Gaps = 15/173 (9%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + DI ++ + VIVNAAN L GGGV GA+++A + KE + I G
Sbjct 2 EITVVKGDITEQ----DVDVIVNAANPGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGT 57
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAY------ENFNSQDILLAP 1125
G + + S +L A +H VGP GE + L + Y + P
Sbjct 58 CPAGEAVITSAGDLQASYIIHAVGPIWKDGEHQEANKLASCYWKALDLAAGKELTSIAFP 117
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+S G++G + +V + TVR + E++ D ++
Sbjct 118 NISTGVYGFPKKLAAEVALYTVRKWAEEEYDTS--IEEIRFVCFDEENLKLYN 168
>sp|Q8Y3S3|Y2759_LISMO Macro domain-containing protein lmo2759
OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679
/ EGD-e) OX=169963 GN=lmo2759 PE=4 SV=1
Length=176
Score = 124 bits (310), Expect = 2e-30, Method: Composition-based stats.
Identities = 45/173 (26%), Positives = 71/173 (41%), Gaps = 15/173 (9%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ I DI ++ VIVNAAN L GGGV GA+++A + KE + I G
Sbjct 2 EITIVKGDITEQE----VDVIVNAANSGLLGGGGVDGAIHQAAGPDLLKECQEVINRIGS 57
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAY------ENFNSQDILLAP 1125
G + + S +L A +H VGP GE + L + Y + P
Sbjct 58 CPAGEAVITSAGDLKATYIIHAVGPIWKDGEHQEANKLASCYWKALDLAAGKDLTSIAFP 117
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEA 1178
+S G++G + +V + TVR D ++ E + D ++
Sbjct 118 NISTGVYGFPKKLAAEVALYTVRKWAEEE-YDTSIKE-IRFVCFDEENLKLYN 168
>sp|Q8PHB6|Y3343_XANAC Macro domain-containing protein XAC3343
OS=Xanthomonas axonopodis pv. citri (strain 306) OX=190486
GN=XAC3343 PE=4 SV=2
Length=179
Score = 123 bits (309), Expect = 2e-30, Method: Composition-based stats.
Identities = 36/145 (25%), Positives = 59/145 (41%), Gaps = 15/145 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY--IKLNG 1073
+ + DI + + VIVNAAN L GGGV GA+++A + + + ++
Sbjct 3 IEVWQGDITE----LDVDVIVNAANESLLGGGGVDGAIHRAAGPRLLEACEALPQVRPGV 58
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENFNS------QDILLA 1124
G + G +L A+ H VGP G + + L Y +
Sbjct 59 RCPTGEIRITDGFDLKARHIFHTVGPVWRDGRHNEPEQLANCYWQSLKLAEQMMLHSIAF 118
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRT 1149
P +S GI+G Q+ ++ V R
Sbjct 119 PAISCGIYGYPLHQAARIAVTETRD 143
>sp|Q9HXU7|Y3693_PSEAE Macro domain-containing protein PA3693
OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP
104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964
GN=PA3693 PE=4 SV=1
Length=173
Score = 123 bits (309), Expect = 2e-30, Method: Composition-based stats.
Identities = 47/179 (26%), Positives = 75/179 (42%), Gaps = 20/179 (11%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
V + DI + A IVNAAN L GGGV GA+++A + L+G
Sbjct 3 EVRVWQGDITRLA----VDAIVNAANSSLLGGGGVDGAIHRAAGAELVAAC---RLLHG- 54
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENFNSQ------DILLAP 1125
G + + G L A +H VGP G+ + +LL + Y + + P
Sbjct 55 CKTGEAKITRGFRLPAAHVIHTVGPVWRGGDNGEAELLASCYRRSLALAEQAGAASVAFP 114
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEP 1184
+S GI+G Q+ + V+ V Q +L E V++ + ++ R + E P
Sbjct 115 AISCGIYGYPLEQAAAIAVEEVCRQRPAHS---SLEEIVLVAFDSSMAERYQRLLGERP 170
>sp|Q8TQD0|Y1614_METAC Macro domain-containing protein MA_1614
OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834
/ JCM 12185 / C2A) OX=188937 GN=MA_1614 PE=4 SV=1
Length=195
Score = 124 bits (311), Expect = 2e-30, Method: Composition-based stats.
Identities = 40/155 (26%), Positives = 66/155 (43%), Gaps = 22/155 (14%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCL 1082
I ++ IVNAAN L GGGV GA+++A + +E LNG G + +
Sbjct 32 IERDITELKVDAIVNAANNTLLGGGGVDGAIHRAAGPGLLEECRT---LNG-CPTGEAKI 87
Query 1083 LSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYEN----FNSQDI--LLAPLLSAGIFG 1133
G+ L AK +H VGP G + + L + Y D+ + P +S G +G
Sbjct 88 TKGYLLPAKYVIHTVGPIWQEGTKGEDEFLASCYRKSLELARKYDVKTIAFPTISTGAYG 147
Query 1134 AKPLQSLQVCVQTVR---------TQVYIAVNDKA 1159
++ ++ V V+ V++ +K
Sbjct 148 FPSERAARIAVSQVKEFLKVNELPEIVFLVCYNKE 182
>sp|Q8IXQ6|PARP9_HUMAN Protein mono-ADP-ribosyltransferase PARP9
OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2
Length=854
Score = 135 bits (341), Expect = 3e-30, Method: Composition-based stats.
Identities = 46/167 (28%), Positives = 74/167 (44%), Gaps = 19/167 (11%)
Query 1033 MVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKK 1091
+VNAAN L HGGG+A AL KA +Q+ES ++ G ++ G + L K+
Sbjct 133 DAVVNAANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEIAVTGAGRLPCKQ 192
Query 1092 CLHVVGPN---LNAGEDIQLLKAA---------YENFNSQDILLAPLLSAGIFGAKPLQS 1139
+H VGP + L+ A Y+N + + + P LS+GIF
Sbjct 193 IIHAVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIK-TVAIPALSSGIFQFP---- 247
Query 1140 LQVCVQTVRTQVYIAVNDKALYEQVVMDYL-DNLKPRVEAPKQEEPP 1185
L +C +T+ + +++ K + + +L N P V A K
Sbjct 248 LNLCTKTIVETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFKAASEF 294
Score = 42.4 bits (98), Expect = 0.13, Method: Composition-based stats.
Identities = 27/126 (21%), Positives = 42/126 (33%), Gaps = 10/126 (8%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-A 1089
VIVN+ N H G VA ++ + M+ E K + G NL
Sbjct 330 TADVIVNSVNPHDITVGPVAKSILQQAGVEMKSE-FLATKAKQFQRSQLVLVTKGFNLFC 388
Query 1090 KKCLHVV------GPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSLQVC 1143
K HV+ P + + L+ E + + P L G K + ++
Sbjct 389 KYIYHVLWHSEFPKPQILKHAMKECLEKCIE--QNITSISFPALGTGNMEIKKETAAEIL 446
Query 1144 VQTVRT 1149
V T
Sbjct 447 FDEVLT 452
>sp|Q8P5Z8|Y3184_XANCP Macro domain-containing protein XCC3184
OS=Xanthomonas campestris pv. campestris (strain ATCC 33913
/ DSM 3586 / NCPPB 528 / LMG 568 / P 25) OX=190485 GN=XCC3184
PE=4 SV=1
Length=179
Score = 123 bits (308), Expect = 3e-30, Method: Composition-based stats.
Identities = 36/145 (25%), Positives = 59/145 (41%), Gaps = 15/145 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDY--IKLNG 1073
+ + DI + + VIVNAAN L GGGV GA+++A + + + ++
Sbjct 3 IEVWQGDITQ----LDVDVIVNAANESLLGGGGVDGAIHRAAGPRLLEACEALPEVRPGV 58
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENFNS------QDILLA 1124
G + G +L A+ H VGP G + + L Y +
Sbjct 59 RCPTGEIRITDGFDLKARHIFHTVGPVWRDGKHNEPEQLANCYWQSLKLAEQMMLHSIAF 118
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRT 1149
P +S GI+G Q+ ++ V R
Sbjct 119 PAISCGIYGYPLYQAARIAVTETRD 143
>sp|Q2EMV9|PAR14_MOUSE Protein mono-ADP-ribosyltransferase PARP14
OS=Mus musculus OX=10090 GN=Parp14 PE=1 SV=3
Length=1817
Score = 136 bits (343), Expect = 4e-30, Method: Composition-based stats.
Identities = 47/182 (26%), Positives = 72/182 (40%), Gaps = 14/182 (8%)
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+K + ++ V+VNAAN +LKH G+A AL+KA +Q E D +K G +
Sbjct 813 VKLFVLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLP 872
Query 1078 GGSCLLSGHNL-AKKCLHVVGPNLNAG---EDIQLLKAAYENF------NSQDILLAPLL 1127
G + + L +H VGP E + LLK + + P +
Sbjct 873 GNAVISKAGKLPCHHVIHAVGPRWKGDKVLECVSLLKKVVRQSLSLAEEHRCRSIAMPAV 932
Query 1128 SAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNT 1187
SAGIF L++CV + + + K + YL L +V E T
Sbjct 933 SAGIFDFP----LELCVANIVSAIKEHFQHKRDTHTLKKIYLVGLPAKVARAFAEAVKTT 988
Query 1188 ED 1189
Sbjct 989 YK 990
Score = 59.0 bits (141), Expect = 1e-06, Method: Composition-based stats.
Identities = 56/374 (15%), Positives = 119/374 (32%), Gaps = 50/374 (13%)
Query 1023 IVKEAQSANPMVIVNAANIHLKHGGG-VAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
+ + Q+A IVN+ + LK G ++ A + +Q+E + VG
Sbjct 1030 VEEGVQNATTHAIVNSISPDLKLNKGPLSQAFLEKAGPKLQEELTR-SGQGVSVDVGTIL 1088
Query 1082 LLSGHNL-AKKCLHVVGPNLNAGEDI-------QLLKAAYENFNSQDI--LLAPLLSAGI 1131
SG NL ++ HVV P + +++ + + + + P + G
Sbjct 1089 QTSGCNLNSRHVFHVVPPPWKSNNSAWSLKIMKNIIRDCLKTTENLSLQSIAFPAIGTGN 1148
Query 1132 FGAKPLQSLQVCVQTV---------RTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE 1182
+ ++ + V +T + + + + D R +
Sbjct 1149 LRFPKPEFAKLIISEVLKFSSRNQLKTLQEVQFLLHPKDHENIQAFSDEFDKRNNGDPSD 1208
Query 1183 EPPNTEDSKTEEKSVVQK----------PVDVKPKIKACIDEVTTTLEETKFLTNKLLLF 1232
+ P ED++ S+ P+ + I EV + + LT L
Sbjct 1209 KNPKAEDTQGIYGSLSSPTLGMHEMNIGPILFQVATGNIIKEVADVIVNSTTLTFDLKS- 1267
Query 1233 ADINGKLYHDSQNMLRGEDMSFLEKDAP-YMV--GDVITSGDITCVVIPSKKAGGTTEML 1289
++ + + + E ++ Y+V G ++ +I VV + + +L
Sbjct 1268 -GVSKAILEGAGQNVEQECSLLAKQSNHGYIVTGGGLLQCKNIIHVVGGNDVKKSVSCVL 1326
Query 1290 SRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKC----------KSAFYVLPSEAPNA 1339
++ Y + G ++ K KS V +
Sbjct 1327 EECEQR----NYSSICLPAIGTGNAQQDPNVVAKAIIDAIEEFVQKKSVQAVKRVKVVIF 1382
Query 1340 KEEILGTVSWNLRE 1353
+ IL N++E
Sbjct 1383 QPHILQFFYDNMKE 1396
Score = 58.6 bits (140), Expect = 2e-06, Method: Composition-based stats.
Identities = 45/255 (18%), Positives = 89/255 (35%), Gaps = 29/255 (11%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ +I+KE VIVN+ + GV+ A+ + +++E K +
Sbjct 1240 FQVATGNIIKEV----ADVIVNSTTLTFDLKSGVSKAILEGAGQNVEQECSLLAKQS--- 1292
Query 1076 TVGGSCLLSGHNL--AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFG 1133
+++G L K +HVVG N +L+ + + + P + G
Sbjct 1293 --NHGYIVTGGGLLQCKNIIHVVGGNDVKKSVSCVLEECEQ--RNYSSICLPAIGTGNAQ 1348
Query 1134 AKPLQSLQVCVQTV-----RTQVYIAVNDKALYEQ--VVMDYLDNLKPRVEAPKQEEPPN 1186
P + + + + V K + Q ++ + DN+K R +P PP
Sbjct 1349 QDPNVVAKAIIDAIEEFVQKKSVQAVKRVKVVIFQPHILQFFYDNMKEREGSP---APPK 1405
Query 1187 TEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDS--- 1243
+K +SV+ K K + T + E K + +
Sbjct 1406 QSPAK---QSVMSKIASFLGFPKQASPKKNTLVLEKKIEHTVFQVCGSGVDSVNKTISWL 1462
Query 1244 QNMLRGEDMSFLEKD 1258
+ ++ E +S+ D
Sbjct 1463 KELITKEQLSYTNDD 1477
>sp|Q93SX7|Y189_ACISE Macro domain-containing protein OS=Acinetobacter
sp. (strain ED45-25) OX=194927 PE=4 SV=1
Length=183
Score = 123 bits (308), Expect = 4e-30, Method: Composition-based stats.
Identities = 42/181 (23%), Positives = 77/181 (43%), Gaps = 24/181 (13%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
V + DI A A IVN+AN L GGG+ ++K M++E + G
Sbjct 4 VHLIQADITAFAVHA----IVNSANKSLLGGGGLDYVIHKKAGPLMKEECVRLNQEKGGC 59
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNL--NAGEDIQLLKAAYENFNSQD------ILLAPL 1126
G + + + NL AK +H VGP + QLL AY N + + P
Sbjct 60 PTGQAEVTTAGNLPAKYLIHAVGPRWLDGEHNEPQLLCDAYSNALFKANEIHALTVSFPC 119
Query 1127 LSAGIFGAKPLQSLQVCVQTVRT---------QVYIAVNDKA--LYEQVVMDYLDNLKPR 1175
+S G++G P ++ ++ + T+ + +V+ + L + ++ +D+ +
Sbjct 120 ISTGVYGFPPQKAAEIAIGTILSMLPQYDHVAEVFFICREDENYLIYKNILSNIDDPNIQ 179
Query 1176 V 1176
+
Sbjct 180 I 180
>sp|Q88SK6|Y3408_LACPL Macro domain-containing protein lp_3408
OS=Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB
8826 / WCFS1) OX=220668 GN=lp_3408 PE=4 SV=1
Length=172
Score = 121 bits (304), Expect = 8e-30, Method: Composition-based stats.
Identities = 41/171 (24%), Positives = 69/171 (40%), Gaps = 20/171 (12%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + DI K IVNAAN L GGGV GA+++A A+ L+G
Sbjct 3 EIKVIHGDITK----MTVDAIVNAANTSLLGGGGVDGAIHRAAGPALLAAC---RPLHG- 54
Query 1075 LTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYENF------NSQDILLAP 1125
G + + G L AK +H GP G ++QLL +Y N N + P
Sbjct 55 CATGEAKITPGFRLPAKYVIHTPGPVWQGGQHNELQLLANSYRNSLNLAAENHCQTVAFP 114
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
+S G++ + + ++T++ + + + + D+ V
Sbjct 115 SISTGVYHFPLSIAAPLALKTLQATAQTTAHT---VQTITIVCFDDQTQNV 162
>sp|Q8CAS9|PARP9_MOUSE Protein mono-ADP-ribosyltransferase PARP9
OS=Mus musculus OX=10090 GN=Parp9 PE=1 SV=2
Length=866
Score = 134 bits (336), Expect = 1e-29, Method: Composition-based stats.
Identities = 48/164 (29%), Positives = 71/164 (43%), Gaps = 17/164 (10%)
Query 1033 MVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKK 1091
+VNAAN +L HG G+AG+L K +Q+ES I G ++VGG + L
Sbjct 135 DAVVNAANENLLHGSGLAGSLVKTGGFEIQEESKRIIANVGKISVGGIAITGAGRLPCHL 194
Query 1092 CLHVVGPNL---NAGEDIQLLKAAYENFNSQ--------DILLAPLLSAGIFGAKPLQSL 1140
+H VGP N+ I+LLK A N + P LS+GIF L
Sbjct 195 IIHAVGPRWTVTNSQTAIELLKFAIRNILDYVTKYDLRIKTVAIPALSSGIFQFP----L 250
Query 1141 QVCVQTVRTQVYIAVNDKALYEQVVMDYL-DNLKPRVEAPKQEE 1183
+C + + + DK ++ + +L N P V + K
Sbjct 251 DLCTSIILETIRLYFQDKQMFGNLREIHLVSNEDPTVASFKSAS 294
Score = 41.2 bits (95), Expect = 0.29, Method: Composition-based stats.
Identities = 27/125 (22%), Positives = 48/125 (38%), Gaps = 14/125 (11%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-A 1089
VIVN+ + G VA ++ + M+KE D K+N + G L
Sbjct 337 TTDVIVNSGYMQDFKSGRVAQSILRQAGVEMEKELD---KVNLSTDYQEVWVTKGFKLSC 393
Query 1090 KKCLHVVGPNLNAG-EDIQLLKAAYENFNSQ------DILLAPLLSAGIFGAKPLQSLQV 1142
+ HV ++ Q+LK A ++ + + + P L G+ K + Q+
Sbjct 394 QYVFHVA---WHSQINKYQILKDAMKSCLEKCLKPDINSISFPALGTGLMDLKKSTAAQI 450
Query 1143 CVQTV 1147
+ V
Sbjct 451 MFEEV 455
>sp|Q460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14
OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3
Length=1801
Score = 133 bits (335), Expect = 3e-29, Method: Composition-based stats.
Identities = 56/296 (19%), Positives = 104/296 (35%), Gaps = 33/296 (11%)
Query 1026 EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
+ V+VNA+N LKH GG+A AL+KA +Q + D +K G L G + +
Sbjct 810 DLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKA 869
Query 1086 HNLA-KKCLHVVGPNLNAGE---DIQLLKAAYENFN------SQDILLAPLLSAGIFGAK 1135
L +H VGP + E + LL+ A + + P +S+G+FG
Sbjct 870 GKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFP 929
Query 1136 PLQSLQVCVQTVRTQVYIAVNDKALYE----QVVMDYLDNLKPRVEAPKQEEPPNTEDSK 1191
+ ++ V ++ + L E V ++ V+ + P+T
Sbjct 930 LGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKATLPDTAAPP 989
Query 1192 TEEKSVVQKPVDVKPKIKACIDEVTTTL--------EETKFLTNKLLLFADIN----GKL 1239
+ K L +T + N + L ++ K
Sbjct 990 GLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKS 1049
Query 1240 YHDSQNMLRGEDMSFLEKDAPYMVGDVITSGD-------ITCVVIPSKKAGGTTEM 1288
+ E++ + + +G V+ + + VV P + G T+ +
Sbjct 1050 LLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSL 1105
Score = 70.1 bits (170), Expect = 5e-10, Method: Composition-based stats.
Identities = 64/419 (15%), Positives = 139/419 (33%), Gaps = 60/419 (14%)
Query 1023 IVKEAQSANPMVIVNAANIHL-KHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSC 1081
+ + Q+A V+VN+ + L G ++ +L + +Q+E D + +++G
Sbjct 1019 VKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDT-VGQGVAVSMGTVL 1077
Query 1082 LLSGHNL-AKKCLHVVGPNLNAGEDIQL------LKAAYENFNSQDI--LLAPLLSAGIF 1132
S NL + LHVV P G L ++ E S + + P + G
Sbjct 1078 KTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNL 1137
Query 1133 GAKPLQSLQVCVQTVRTQVYIAVNDKALY--EQVVMDYLDNLKPRVEAPKQE-------- 1182
G + + + ++V+ + L ++V + ++A E
Sbjct 1138 GFPK----NIFAELIISEVFKFSSKNQLKTLQEVHFLLHPSDHENIQAFSDEFARRANGN 1193
Query 1183 ----EPPNTEDSKTEEKSVVQKP-VDVKPKIKACIDEV----TTTLEETKFL---TNKLL 1230
+ P +D++ +V + KI + I +V T E + +N
Sbjct 1194 LVSDKIPKAKDTQGFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFN 1253
Query 1231 LFADINGKLYHDSQNMLRGE-DMSFLEKDAPYMV--GDVITSGDITCVVIPSKKAGGTTE 1287
L A ++ + + + E ++ Y++ G + +I V+ + +
Sbjct 1254 LKAGVSKAILECAGQNVERECSQQAQQRKNDYIITGGGFLRCKNIIHVIGGNDVKSSVSS 1313
Query 1288 MLSRALKKVPVDEYITTYPGQGCAGYTLEEAKTALKKCKSAFYVLPSEAPNAKEEILGTV 1347
+L KK Y + G + + A I V
Sbjct 1314 VLQECEKK----NYSSICLPAIGTGNAKQHPDKVAEAIIDA--------------IEDFV 1355
Query 1348 SWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDYGVRFFFYTSKEP 1406
+ + + L + A M +R+ + Q+ ++ F ++ + P
Sbjct 1356 QKGSAQSVKKVKVVIFLPQVLDVFYANMK--KREGTQLSSQQSVMSKLASFLGFSKQSP 1412
Score = 59.3 bits (142), Expect = 9e-07, Method: Composition-based stats.
Identities = 30/185 (16%), Positives = 59/185 (32%), Gaps = 16/185 (9%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ DI KE VIVN+ + GV+ A+ + +++E +
Sbjct 1229 FQVASGDITKEE----ADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQRKN- 1283
Query 1076 TVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGA 1134
+ G L K +HV+G N +L+ + + + P + G
Sbjct 1284 ---DYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEK--KNYSSICLPAIGTGNAKQ 1338
Query 1135 KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEE 1194
P + + + + V +VV+ P+V E ++
Sbjct 1339 HPDKVAEAIIDAIEDFVQKGSAQSVKKVKVVI-----FLPQVLDVFYANMKKREGTQLSS 1393
Query 1195 KSVVQ 1199
+ V
Sbjct 1394 QQSVM 1398
>sp|Q8RHQ2|Y1951_FUSNN Uncharacterized protein FN1951 OS=Fusobacterium
nucleatum subsp. nucleatum (strain ATCC 25586 / DSM
15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG
13131 / VPI 4355) OX=190304 GN=FN1951 PE=4 SV=1
Length=175
Score = 120 bits (300), Expect = 4e-29, Method: Composition-based stats.
Identities = 46/179 (26%), Positives = 77/179 (43%), Gaps = 20/179 (11%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI K + IVNAAN L+ GGGV GA+ KA + +E + G
Sbjct 6 IKLISGDITKIPEV---EAIVNAANSSLEMGGGVCGAIFKAAGSELAQECKEI----GGC 58
Query 1076 TVGGSCLLSGHNLA-KKCLHVVGPNLNAGEDIQ---LLKAAYENF---NSQDI--LLAPL 1126
G + + G+NL K +H VGP + GE+ + L A YE+ N + I + P
Sbjct 59 NTGEAVITKGYNLPNKYIIHTVGPRYSTGENREAERLASAYYESLKLANEKGIRRIAFPS 118
Query 1127 LSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPP 1185
+S GI+ + ++ + T ++ +++ LD V K ++
Sbjct 119 ISTGIYRFPVDEGAKIAL----TTAIKFLDKNPSSFDLILWVLDEKTYIVYKEKYKKLL 173
>sp|Q985D2|Y7730_RHILO Macro domain-containing protein mll7730
OS=Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 /
MAFF 303099) OX=266835 GN=mll7730 PE=4 SV=1
Length=176
Score = 119 bits (297), Expect = 1e-28, Method: Composition-based stats.
Identities = 48/173 (28%), Positives = 77/173 (45%), Gaps = 21/173 (12%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
D + I DI K + IVNAAN L GGGV GA+++A ++ E LNG
Sbjct 6 DRIRIHTGDITK----LDVDAIVNAANTLLLGGGGVDGAIHRAAGRELEVEC---RMLNG 58
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAG--EDIQLLKAAYE------NFNSQDILLA 1124
VG + + G+ L A+ +H VGP G + +LL + Y N +
Sbjct 59 -CKVGDAKITKGYKLPARHIIHTVGPVWQGGGKGEAELLASCYRSSLELAAANDCRSVAF 117
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
P +S G++ ++ + V TV + + +KA+ E V+ D ++
Sbjct 118 PAISTGVYRYPKDEATGIAVGTVS----MVIEEKAMPETVIFCCFDEQTAQLY 166
>sp|Q9ZBG3|Y6450_STRCO Macro domain-containing protein SCO6450
OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
OX=100226 GN=SCO6450 PE=4 SV=1
Length=169
Score = 118 bits (295), Expect = 1e-28, Method: Composition-based stats.
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 14/145 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLN--G 1073
+ + DI +++ IVNAAN L GGGV GA+++ A+ E +
Sbjct 4 ITLVQGDITRQS----ADAIVNAANSSLLGGGGVDGAIHRRGGPAILAECRRLRAGHLGK 59
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-LLKAAYENF------NSQDILLAP 1125
L G + + +L A+ +H VGP +A ED LL + Y + P
Sbjct 60 GLPTGRAVATTAGDLDARWVIHTVGPVWSATEDRSGLLASCYRESLRTADELGARTVAFP 119
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQ 1150
+S G++ + ++ V+TV T
Sbjct 120 AISTGVYRWPMDDAARIAVETVATT 144
>sp|Q9KHE2|Y189_STRGR Macro domain-containing protein in non 5'region
OS=Streptomyces griseus OX=1911 PE=4 SV=1
Length=177
Score = 117 bits (292), Expect = 4e-28, Method: Composition-based stats.
Identities = 38/158 (24%), Positives = 63/158 (40%), Gaps = 14/158 (9%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
++ V + DI ++ VIVNAAN L GGGV GA+++ + +
Sbjct 3 TSVSPVVRLVRGDITDQS----VDVIVNAANSSLLGGGGVDGAIHRRGGPDILAACRELR 58
Query 1070 KLN--GPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGED-IQLLKAAYE------NFNSQ 1119
L G + + L A+ +H VGP + +D LL + Y
Sbjct 59 ASRYGKGLPTGQAVATTAGRLDARWIVHTVGPVFSGAQDRSALLASCYRESLRLAAELGA 118
Query 1120 DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVND 1157
+ P +S GI+G ++ V+TV + V +
Sbjct 119 RSIAFPAISTGIYGWPMDDGARIAVRTVLAETVEPVEE 156
>sp|Q9RS39|Y2288_DEIRA Macro domain-containing protein DR_2288
OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 /
JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279
/ VKM B-1422 / R1) OX=243230 GN=DR_2288 PE=4 SV=1
Length=170
Score = 116 bits (291), Expect = 4e-28, Method: Composition-based stats.
Identities = 33/146 (23%), Positives = 60/146 (41%), Gaps = 20/146 (14%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+ + DI + +V AAN L GGGV G +++A + + I+ G
Sbjct 3 LELVQGDIAHQ----PVDAVVTAANKQLMGGGGVDGVIHRAAGPRLLQA----IRPIGGT 54
Query 1076 TVGGSCLLSGHNL----AKKCLHVVGPNLNAGE--DIQLLKAAYENF------NSQDILL 1123
G + + +L K +H VGP G+ + +LL AY N +
Sbjct 55 PTGTAVITPAFDLERQGVKYVIHAVGPIWRGGQHGEAELLAGAYRESLRLGVENGCRSVA 114
Query 1124 APLLSAGIFGAKPLQSLQVCVQTVRT 1149
P +S G++G ++ + + T++
Sbjct 115 FPSISTGVYGYPLDRAAPIALATIQD 140
>sp|Q3UYG8|MACD2_MOUSE ADP-ribose glycohydrolase MACROD2 OS=Mus
musculus OX=10090 GN=Macrod2 PE=1 SV=1
Length=475
Score = 125 bits (313), Expect = 5e-28, Method: Composition-based stats.
Identities = 52/270 (19%), Positives = 100/270 (37%), Gaps = 25/270 (9%)
Query 954 EDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLT 1013
E+ + L + + + L E+ + + + + + Q L+
Sbjct 13 EEKERLLKMTLEERRKEYIRDYVSLSTILSW-KEEMKSKGQNDEENTQEAPQM--KKSLS 69
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
+ V++ DI IVNAAN L GGGV G +++A + E + LNG
Sbjct 70 EKVSLYRGDIT----LLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRN---LNG 122
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNA---GEDIQLLKAAYENF------NSQDILL 1123
G + + G++L AK +H VGP G + L Y++ N+ +
Sbjct 123 -CETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVA 181
Query 1124 APLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEE 1183
P +S GI+G + + + T++ + ++++ + ++ K E
Sbjct 182 FPCISTGIYGFPNEPAAVIALGTIKE---WLAKNHQEVDRIIFCVFLEVDFKIYKKKMNE 238
Query 1184 PPNTEDSKTEEKSVVQKPVDVKPKIKACID 1213
+D+ E K P+ K
Sbjct 239 FFPVDDN-NEGTDADMKEDSEGPEPKGLSP 267
>sp|Q97AU0|Y719_THEVO Uncharacterized protein TV0719 OS=Thermoplasma
volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 /
NBRC 15438 / GSS1) OX=273116 GN=TV0719 PE=4 SV=1
Length=186
Score = 116 bits (291), Expect = 7e-28, Method: Composition-based stats.
Identities = 39/144 (27%), Positives = 60/144 (42%), Gaps = 14/144 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP- 1074
+ I DI N IVNAAN L GGGV GA++ + E + + P
Sbjct 11 IEIIEGDIT----DVNCEAIVNAANPSLMGGGGVDGAIHLKGGKTIDLECAELRRTKWPK 66
Query 1075 -LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ--LLKAAYENF-----NSQDILLAP 1125
L G + + SG L AK +H VGP E+ L + Y + + + P
Sbjct 67 GLPPGEADITSGGKLKAKYVIHTVGPIYRGQEEDAETLYSSYYRSLEIAKIHGIKCIAFP 126
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRT 1149
+S GI+G ++ + ++ V
Sbjct 127 AISTGIYGYPFEEASVIALKAVTD 150
>sp|Q6PAV8|MACD2_XENLA ADP-ribose glycohydrolase MACROD2 OS=Xenopus
laevis OX=8355 GN=macrod2 PE=2 SV=1
Length=418
Score = 123 bits (308), Expect = 7e-28, Method: Composition-based stats.
Identities = 46/210 (22%), Positives = 79/210 (38%), Gaps = 21/210 (10%)
Query 981 WLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAAN 1040
LD E + +E + L + V+ DI + IVNAAN
Sbjct 35 SLDKIPSLMEELKSKASSDDESPEEIQVKNSLCEKVSFYKGDITQLE----VDAIVNAAN 90
Query 1041 IHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPN 1099
L GGGV G +++A+ ++ E + G G + + G+ L AK +H VGP
Sbjct 91 TSLLGGGGVDGCIHRASGPSLLAECREL----GGCETGQAKITCGYELPAKYVIHTVGPI 146
Query 1100 LNAG---EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQ 1150
Q L + Y + N + P +S GI+G + V + TV+
Sbjct 147 ARGHITPNHKQDLASCYNSSLTLATENDIRTIAFPCISTGIYGYPNEPAANVALTTVKE- 205
Query 1151 VYIAVNDKALYEQVVMDYLDNLKPRVEAPK 1180
++ ++V+ + ++ K
Sbjct 206 --FLKKNRDKIDRVIFCVFLEVDFKIYKRK 233
>sp|Q44020|YGB2_CUPNE Macro domain-containing protein in gbd 3'region
OS=Cupriavidus necator OX=106590 PE=4 SV=1
Length=173
Score = 115 bits (289), Expect = 9e-28, Method: Composition-based stats.
Identities = 45/173 (26%), Positives = 73/173 (42%), Gaps = 17/173 (10%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNG 1073
+++ + DI + IVNAAN L GGGV GA++ A A+++ G
Sbjct 4 EHLQVVHGDITRME----VDAIVNAANSGLLGGGGVDGAIHGAGGSAIKEACRAIRDTQG 59
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENF------NSQDILLA 1124
G + + +G +L A +H VGP G+ + +LL AY N + L
Sbjct 60 GCPTGEAVITTGGHLPAPYVIHAVGPVWQGGDQGEDELLANAYRNSIRLAAQHHLRRLAF 119
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
P +S GI+ ++ + + VR + A EQV D+ R+
Sbjct 120 PNISTGIYAFPRERAADIAIAAVREALAAA----PEIEQVTFVCFDDENYRLY 168
>sp|Q9EYI6|Y189_STRNO Macro domain-containing protein in sno 5'region
OS=Streptomyces nogalater OX=38314 PE=4 SV=1
Length=181
Score = 115 bits (287), Expect = 2e-27, Method: Composition-based stats.
Identities = 42/163 (26%), Positives = 69/163 (42%), Gaps = 20/163 (12%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI-KLNGP 1074
+ + DI ++ + +VNAAN L GGGV GA+++ A+ E G
Sbjct 4 ITLVQGDITRQ----HADALVNAANSSLLGGGGVDGAIHRRGGPAILAECRALRASRYGE 59
Query 1075 -LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-LLKAAYENF------NSQDILLAP 1125
L G + + +L A+ +H VGP ++ ED LL + Y + P
Sbjct 60 GLPTGRAVATTAGDLDARWVIHTVGPVWSSTEDRSDLLASCYRESLRLAGELGARTVAFP 119
Query 1126 LLSAGIFGAKPLQSLQVCVQTVRTQ------VYIAVNDKALYE 1162
LS G++ + ++ V+TVRT V + D Y+
Sbjct 120 ALSTGVYRWPMGDAARIAVETVRTTPTAVEEVRFVLFDTHAYD 162
>sp|A1Z1Q3|MACD2_HUMAN ADP-ribose glycohydrolase MACROD2 OS=Homo
sapiens OX=9606 GN=MACROD2 PE=1 SV=2
Length=425
Score = 120 bits (301), Expect = 7e-27, Method: Composition-based stats.
Identities = 56/289 (19%), Positives = 106/289 (37%), Gaps = 27/289 (9%)
Query 1010 LKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYI 1069
LT+ V++ DI IVNAAN L GGGV G +++A + E +
Sbjct 66 KSLTEKVSLYRGDIT----LLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRN-- 119
Query 1070 KLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNA---GEDIQLLKAAYENF------NSQ 1119
LNG G + + G++L AK +H VGP G + L Y++ N+
Sbjct 120 -LNG-CDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNI 177
Query 1120 DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAP 1179
+ P +S GI+G + + + T++ + ++++ + ++
Sbjct 178 RSVAFPCISTGIYGFPNEPAAVIALNTIKE---WLAKNHHEVDRIIFCVFLEVDFKIYK- 233
Query 1180 KQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKL 1239
K+ + D EE+ V+ D ++ + E + + + G
Sbjct 234 KKMNEFFSVDDNNEEEEDVEMKEDSDE--NGPEEKQSVEEMEEQSQDADGVNTVTVPG-- 289
Query 1240 YHDSQNMLRGEDMSFLEKDAPYMVGDVITSGDITCVVIPSKKAGGTTEM 1288
S+ + KD G +T + P + +T+
Sbjct 290 -PASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKN 337
>sp|Q9BQ69|MACD1_HUMAN ADP-ribose glycohydrolase MACROD1 OS=Homo
sapiens OX=9606 GN=MACROD1 PE=1 SV=2
Length=325
Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats.
Identities = 41/187 (22%), Positives = 73/187 (39%), Gaps = 23/187 (12%)
Query 990 EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGV 1049
E+ EEP + +L + +++ DI K IVNAAN L GGGV
Sbjct 130 EMAKGVAVKVEEPRYK--KDKQLNEKISLLRSDITKLE----VDAIVNAANSSLLGGGGV 183
Query 1050 AGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQL 1108
G +++A + E G + + G+ L AK +H VGP
Sbjct 184 DGCIHRAAGPLLTDECRTL----QSCKTGKAKITGGYRLPAKYVIHTVGPIAYGEPSASQ 239
Query 1109 ---LKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKA 1159
L++ Y + + + P +S G+FG + ++ + T+R K
Sbjct 240 AAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPCEAAAEIVLATLRE---WLEQHKD 296
Query 1160 LYEQVVM 1166
+++++
Sbjct 297 KVDRLII 303
>sp|Q2KHU5|MACD1_BOVIN ADP-ribose glycohydrolase MACROD1 OS=Bos
taurus OX=9913 GN=MACROD1 PE=2 SV=1
Length=325
Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats.
Identities = 41/198 (21%), Positives = 73/198 (37%), Gaps = 23/198 (12%)
Query 990 EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGV 1049
E EEP ++ +L + +++ DI K IVNAAN L GGGV
Sbjct 130 ETAKGVTVKVEEP--KYKKDKQLNEKISLFRGDITKLE----VDAIVNAANSSLLGGGGV 183
Query 1050 AGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQL 1108
G +++A + E G + + G+ L AK +H VGP +
Sbjct 184 DGCIHRAAGPLLTDECRTL----QNCETGKAKITCGYRLPAKYVIHTVGPIAHGEPSASQ 239
Query 1109 ---LKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKA 1159
L++ Y + + P +S G+FG + +V + +R K
Sbjct 240 AAELRSCYLSSLDLLLEHRLRSAAFPCISTGVFGYPNEAAAEVVLTALRE---WLEQHKD 296
Query 1160 LYEQVVMDYLDNLKPRVE 1177
+++++ +
Sbjct 297 KVDRLIICVFLEKDENIY 314
>sp|Q9HJ67|Y1105_THEAC Uncharacterized protein Ta1105 OS=Thermoplasma
acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062
/ NBRC 15155 / AMRC-C165) OX=273075 GN=Ta1105 PE=4 SV=2
Length=196
Score = 109 bits (272), Expect = 3e-25, Method: Composition-based stats.
Identities = 37/143 (26%), Positives = 63/143 (44%), Gaps = 15/143 (10%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP- 1074
+A++ DI + + IVNAAN L GGGV GA++ A + E + P
Sbjct 11 LAVEVGDITES----DAEAIVNAANSSLMGGGGVDGAIHSAAGPELNGELVKIRRERYPN 66
Query 1075 -LTVGGSCLLSGHNL-AKKCLHVVGPNLNAGE--DIQLLKAAYENFNSQ------DILLA 1124
L G + + G+ L A +H VGP G + +L +Y + +
Sbjct 67 GLPPGEAVITRGYRLKASHIIHTVGPVWMGGRNGEDDVLYRSYRSCLDLAREFGIHDIAF 126
Query 1125 PLLSAGIFGAKPLQSLQVCVQTV 1147
P LS G +G ++ ++ +++V
Sbjct 127 PALSTGAYGFPFDRAERIAIRSV 149
>sp|Q8K4G6|MACD1_RAT ADP-ribose glycohydrolase MACROD1 (Fragment)
OS=Rattus norvegicus OX=10116 GN=Macrod1 PE=2 SV=2
Length=258
Score = 110 bits (274), Expect = 9e-25, Method: Composition-based stats.
Identities = 38/184 (21%), Positives = 71/184 (39%), Gaps = 21/184 (11%)
Query 1005 QFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE 1064
++ +L + +++ DI K IVNAAN L GGGV G +++A + E
Sbjct 76 KYKKDKQLNEKISLFRGDITKLE----VDAIVNAANNSLLGGGGVDGCIHRAAGSLLTDE 131
Query 1065 SDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQL---LKAAYENF---- 1116
G + + G+ L AK +H VGP L++ Y +
Sbjct 132 CRTL----QNCETGKAKITCGYRLPAKHVIHTVGPIAVGQPTASQAAELRSCYLSSLDLL 187
Query 1117 --NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKP 1174
+ + P +S G+FG ++ +V + T+R K +++++
Sbjct 188 LEHRLRSVAFPCISTGVFGYPNEEAAEVVLATLRE---WLEQHKDKVDRLIICVFLEKDE 244
Query 1175 RVEA 1178
+
Sbjct 245 GIYQ 248
>sp|Q922B1|MACD1_MOUSE ADP-ribose glycohydrolase MACROD1 OS=Mus
musculus OX=10090 GN=Macrod1 PE=1 SV=2
Length=323
Score = 110 bits (276), Expect = 2e-24, Method: Composition-based stats.
Identities = 40/187 (21%), Positives = 74/187 (40%), Gaps = 23/187 (12%)
Query 990 EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGV 1049
E E+P ++ +L + +++ DI K IVNAAN L GGGV
Sbjct 128 ETAKGLAVKVEDP--KYKKDKQLNEKISLYRGDITKLE----VDAIVNAANSSLLGGGGV 181
Query 1050 AGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQL 1108
G +++A + E G + + G+ L AK +H VGP
Sbjct 182 DGCIHRAAGSLLTDECRTL----QNCETGKAKITCGYRLPAKYVIHTVGPIAVGQPTASQ 237
Query 1109 ---LKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKA 1159
L++ Y + + + P +S G+FG ++ +V + ++R K
Sbjct 238 AAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPNEEAAEVVLASLRE---WLEQHKD 294
Query 1160 LYEQVVM 1166
+++++
Sbjct 295 KVDRLII 301
>sp|Q9WJC7|POLN_EEVVM Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain Mena II) OX=36384 PE=3 SV=3
Length=2499
Score = 109 bits (271), Expect = 9e-22, Method: Composition-based stats.
Identities = 74/276 (27%), Positives = 103/276 (37%), Gaps = 50/276 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + DI +A VIVNAAN + G GV GAL + ES D
Sbjct 1329 CAPSYHVVRGDIA----TATEGVIVNAANSKGQPGSGVCGALYRK-----YPESFDL--- 1376
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDIL 1122
P+ VG + L+ G + K +H VGPN + +++ L AYE N N+ +
Sbjct 1377 -QPIEVGKARLVKGSS--KHIIHAVGPNFSKVSEVEGDKQLAEAYESIAKIINDNNYRSV 1433
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
PLLS GIF + L L + T V I DK +V + + + V
Sbjct 1434 AIPLLSTGIFAGNKDRLMQSLNHLLTALDTTDADVAIYCRDK--KWEVTLKEVVARREAV 1491
Query 1177 EAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTT------LEETKFLTNKLL 1230
EE +EDS E V K + T+ LE TKF
Sbjct 1492 -----EEICISEDSSVAEPDAELVRVHPKSSLAGRKGYSTSDGKTFSYLEGTKF-HQAAK 1545
Query 1231 LFADING------KLYHDSQNMLRGEDMSFLEKDAP 1260
A+IN + + GE MS + P
Sbjct 1546 DMAEINAMWPTATEANEQVCLYILGESMSSIRSKCP 1581
>sp|Q8V294|POLN_EEVVC Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain CPA201) OX=376610 PE=3 SV=3
Length=2497
Score = 109 bits (271), Expect = 1e-21, Method: Composition-based stats.
Identities = 75/276 (27%), Positives = 105/276 (38%), Gaps = 50/276 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + DI +A VIVNAAN + G GV GAL + ES D
Sbjct 1329 CAPSYHVVRGDIA----TATEGVIVNAANSKGQPGSGVCGALYRK-----YPESFDL--- 1376
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDIL 1122
P+ VG + L+ G++ K +H VGPN N +++ L AYE N N+ +
Sbjct 1377 -QPIEVGKARLVKGNS--KHLIHAVGPNFNKVSEVEGDKQLAEAYESIARIINDNNYRSV 1433
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
PLLS GIF + L L + T V I DK +V + + + V
Sbjct 1434 AIPLLSTGIFAGNKDRLMQSLNHLLTALDTTDADVAIYCRDK--KWEVTLKEVVARREAV 1491
Query 1177 EAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTT------LEETKFLTNKLL 1230
EE +EDS E V K + T+ LE TKF
Sbjct 1492 -----EEICISEDSSVAEPDAELVRVHPKSSLAGRKGYSTSDGKTFSYLEGTKF-HQAAK 1545
Query 1231 LFADINGKLYHDSQN------MLRGEDMSFLEKDAP 1260
A+IN ++ + GE MS + P
Sbjct 1546 DMAEINAMWPAATEANEQVCLYILGESMSSIRSKCP 1581
>sp|P27282|POLN_EEVVT Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain Trinidad donkey) OX=11038 PE=1 SV=3
Length=2493
Score = 108 bits (270), Expect = 1e-21, Method: Composition-based stats.
Identities = 74/276 (27%), Positives = 100/276 (36%), Gaps = 50/276 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + DI +A VI+NAAN + GGGV GAL K ES D
Sbjct 1329 CAPSYHVVRGDIA----TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL--- 1376
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDIL 1122
P+ VG + L+ G AK +H VGPN N +++ L AYE N N+ +
Sbjct 1377 -QPIEVGKARLVKG--AAKHIIHAVGPNFNKVSEVEGDKQLAEAYESIAKIVNDNNYKSV 1433
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
PLLS GIF + L L + T V I DK + +
Sbjct 1434 AIPLLSTGIFSGNKDRLTQSLNHLLTALDTTDADVAIYCRDKKWEMTL-------KEAVA 1486
Query 1177 EAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTT------LEETKFLTNKLL 1230
EE ++DS E V K + T+ LE TKF
Sbjct 1487 RREAVEEICISDDSSVTEPDAELVRVHPKSSLAGRKGYSTSDGKTFSYLEGTKF-HQAAK 1545
Query 1231 LFADING------KLYHDSQNMLRGEDMSFLEKDAP 1260
A+IN + + GE MS + P
Sbjct 1546 DIAEINAMWPVATEANEQVCMYILGESMSSIRSKCP 1581
>sp|P36328|POLN_EEVVP Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain P676) OX=36385 PE=1 SV=2
Length=2493
Score = 108 bits (270), Expect = 1e-21, Method: Composition-based stats.
Identities = 74/276 (27%), Positives = 100/276 (36%), Gaps = 50/276 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + DI +A VI+NAAN + GGGV GAL K ES D
Sbjct 1329 CAPSYHVVRGDIA----TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL--- 1376
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDIL 1122
P+ VG + L+ G AK +H VGPN N +++ L AYE N N+ +
Sbjct 1377 -QPIEVGKARLVKG--AAKHIIHAVGPNFNKVSEVEGDKQLAEAYESIAKIVNDNNYKSV 1433
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
PLLS GIF + L L + T V I DK + +
Sbjct 1434 AIPLLSTGIFSGNKDRLTQSLNHLLTALDTTDADVAIYCRDKKWEMTL-------KEAVA 1486
Query 1177 EAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTT------LEETKFLTNKLL 1230
EE ++DS E V K + T+ LE TKF
Sbjct 1487 RREAVEEICISDDSSVTEPDAELVRVHPKSSLAGRKGYSTSDGKTFSYLEGTKF-HQAAK 1545
Query 1231 LFADING------KLYHDSQNMLRGEDMSFLEKDAP 1260
A+IN + + GE MS + P
Sbjct 1546 DIAEINAMWPVATEANEQVCMYILGESMSSIRSKCP 1581
>sp|P36327|POLN_EEVV3 Polyprotein P1234 OS=Venezuelan equine encephalitis
virus (strain 3880) OX=36382 PE=3 SV=3
Length=2485
Score = 108 bits (270), Expect = 1e-21, Method: Composition-based stats.
Identities = 75/276 (27%), Positives = 100/276 (36%), Gaps = 50/276 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ + DI +A VI+NAAN + GGGV GAL K ES D
Sbjct 1329 CAPSYHVVRGDIA----TATEGVIINAANSKGQPGGGVCGALYKKF-----PESFDL--- 1376
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDIL 1122
P+ VG + L+ G AK +H VGPN N +I+ L AYE N N+ +
Sbjct 1377 -QPIEVGKARLVKG--AAKHIIHAVGPNFNKVSEIEGDKQLAEAYESIAKIVNDNNYKSV 1433
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRV 1176
PLLS GIF + L L + T V I DK + +
Sbjct 1434 AIPLLSTGIFSGNKDRLTQSLNHLLTALDTTDADVAIYCRDKKWEMTL-------KEAVA 1486
Query 1177 EAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKIKACIDEVTTT------LEETKFLTNKLL 1230
EE ++DS E V K + T+ LE TKF
Sbjct 1487 RREAVEEICISDDSSVTEPDAELVRVHPKSSLAGRKGYSTSDGKTFSYLEGTKF-HQAAK 1545
Query 1231 LFADING------KLYHDSQNMLRGEDMSFLEKDAP 1260
A+IN + + GE MS + P
Sbjct 1546 DIAEINAMWPVATEANEQVCMYILGESMSSIRSKCP 1581
>sp|O59182|Y1513_PYRHO Uncharacterized protein PH1513 OS=Pyrococcus
horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974
/ NBRC 100139 / OT-3) OX=70601 GN=PH1513 PE=4 SV=1
Length=190
Score = 95.5 bits (236), Expect = 2e-20, Method: Composition-based stats.
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 23/165 (14%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKES----DDYIKL 1071
I DI K IVNAAN +L+HGGGVA A+ KA +G + + + ++ +
Sbjct 5 FKIVRGDITK----FRAEAIVNAANKYLEHGGGVAYAIAKAASGDVSEYTRISKEEMRRQ 60
Query 1072 NGP--LTVGGSCLLSGHNL----AKKCLHVVGP----NLNAGEDIQLLKAAYENFNSQD- 1120
G + G + L K +H VGP + ++ +L A D
Sbjct 61 LGKDWIEHGEVVVTPPMKLKENGVKYVIHTVGPYCGGVWSKDKEEKLKLAILGALKKADE 120
Query 1121 ----ILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALY 1161
+ P +SAGI+G + ++ + V+ + +A + K +Y
Sbjct 121 LGVKSIAFPAISAGIYGCPLKEVVRTFKEVVKEFLKVANHVKEVY 165
>sp|Q9V0Y3|Y656_PYRAB Uncharacterized protein PYRAB06560 OS=Pyrococcus
abyssi (strain GE5 / Orsay) OX=272844 GN=PYRAB06560
PE=4 SV=2
Length=183
Score = 90.9 bits (224), Expect = 7e-19, Method: Composition-based stats.
Identities = 44/175 (25%), Positives = 70/175 (40%), Gaps = 32/175 (18%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE----SDDYIKL 1071
+ DI + IVNAAN +L+HGGGVA A+ KA +G + + ++ K
Sbjct 2 FRVVHGDITR----FKAEAIVNAANKYLEHGGGVAYAIAKAASGDVSEYIRISKEEMRKQ 57
Query 1072 NGP--LTVGGSCLLSGHNLA----KKCLHVVGPNLNAG---EDIQLLKAAYENFNSQ--- 1119
G + G + NLA K +H VGP + + L+ A +
Sbjct 58 IGRDWIEHGEVVVTPPLNLAKNGVKYVIHTVGPYCGGKWDEDKRKKLELAILGALKKADE 117
Query 1120 ---DILLAPLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKALYE 1162
+ P +SAGI+G + ++ V T VY+ + + YE
Sbjct 118 LGVRSIAFPAISAGIYGCPLEEVVKTFKLVVNEFLKSAKNVTDVYLVLYSERDYE 172
>sp|O28751|Y1521_ARCFU ADP-ribose glycohydrolase AF_1521 OS=Archaeoglobus
fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628
/ NBRC 100126 / VC-16) OX=224325 GN=AF_1521 PE=1 SV=2
Length=192
Score = 88.6 bits (218), Expect = 5e-18, Method: Composition-based stats.
Identities = 41/179 (23%), Positives = 70/179 (39%), Gaps = 30/179 (17%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKES----DDYIKL 1071
+ + DI + IVNAAN L+HGGGVA A+ KA G + +
Sbjct 14 LKLAQGDITQ----YPAKAIVNAANKRLEHGGGVAYAIAKACAGDAGLYTEISKKAMREQ 69
Query 1072 NGP--LTVGGSCLLSGHNLA----KKCLHVVGPNLNAGEDIQLLKAAYENFN-------- 1117
G + G + NL K H VGP + +L + Y+ F
Sbjct 70 FGRDYIDHGEVVVTPAMNLEERGIKYVFHTVGPICSGMWSEELKEKLYKAFLGPLEKAEE 129
Query 1118 -SQDILLAPLLSAGIFGAKPLQSLQVCVQTVR-------TQVYIAVNDKALYEQVVMDY 1168
+ + P +SAGI+G + ++ ++ V+ +V + + D+ E + +
Sbjct 130 MGVESIAFPAVSAGIYGCDLEKVVETFLEAVKNFKGSAVKEVALVIYDRKSAEVALKVF 188
>sp|Q8U0P9|Y1536_PYRFU Uncharacterized protein PF1536 OS=Pyrococcus
furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
OX=186497 GN=PF1536 PE=4 SV=1
Length=183
Score = 81.7 bits (200), Expect = 1e-15, Method: Composition-based stats.
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 32/178 (18%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE---SDD-YIKL 1071
+ + DI K IVNAAN +L+HGGGVA A+ KA G +++ S + +
Sbjct 2 IKVVKGDITK----FRAEAIVNAANKYLEHGGGVAYAIAKAAAGDVREYIRISKEAMREQ 57
Query 1072 NGP--LTVGGSCLLSGHNL----AKKCLHVVGPNLNAG---EDIQLLKAAYENFNSQ--- 1119
G + G + L K +H VGP + LK A +
Sbjct 58 LGKDWIDHGEVVVTPPLQLEKNGVKYVIHTVGPYCGGSWDEDKKSKLKLAILGALKKADE 117
Query 1120 ---DILLAPLLSAGIFGAKPLQSLQVCVQTVRT---------QVYIAVNDKALYEQVV 1165
+ P +SAGI+G + ++ V+ V+ +V++ + + YE+ +
Sbjct 118 LGVKSIAFPAISAGIYGCPLEKVVETFVEVVKEFLPSAKSLREVFLVLYSQEDYEKAL 175
>sp|Q8NYB7|ADPRH_STAAW Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain MW2) OX=196620 GN=MW0302 PE=3 SV=1
Length=266
Score = 81.3 bits (199), Expect = 8e-15, Method: Composition-based stats.
Identities = 34/154 (22%), Positives = 64/154 (42%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENF----- 1116
I+ G VG + + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKITRGYNLPAKYIIHTVGPQIRRLPVSKMNQDLLAKCYLSCLKLAD 199
Query 1117 -NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+S + + +S G+F ++ ++ V+TV +
Sbjct 200 QHSLNHVAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|Q6GCE6|ADPRH_STAAS Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain MSSA476) OX=282459 GN=SAS0302 PE=3 SV=1
Length=266
Score = 81.3 bits (199), Expect = 8e-15, Method: Composition-based stats.
Identities = 34/154 (22%), Positives = 64/154 (42%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENF----- 1116
I+ G VG + + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKITRGYNLPAKYIIHTVGPQIRRLPVSKMNQDLLAKCYLSCLKLAD 199
Query 1117 -NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+S + + +S G+F ++ ++ V+TV +
Sbjct 200 QHSLNHVAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|Q5HIW9|ADPRH_STAAC Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain COL) OX=93062 GN=SACOL0396 PE=3 SV=1
Length=266
Score = 81.3 bits (199), Expect = 9e-15, Method: Composition-based stats.
Identities = 34/154 (22%), Positives = 64/154 (42%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENF----- 1116
I+ G VG + + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKITRGYNLSAKYIIHTVGPQIRRLPVSKMNQDLLAKCYLSCLKLAD 199
Query 1117 -NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+S + + +S G+F ++ ++ V+TV +
Sbjct 200 QHSLNHVAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|Q8P0X2|ADPRH_STRP8 Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M18 (strain MGAS8232) OX=186103 GN=spyM18_1168
PE=3 SV=1
Length=270
Score = 81.3 bits (199), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/140 (22%), Positives = 53/140 (38%), Gaps = 18/140 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGRHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTV 1147
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTV 231
>sp|Q5XC09|ADPRH_STRP6 Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
OX=286636 GN=M6_Spy0919 PE=3 SV=1
Length=270
Score = 80.9 bits (198), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/140 (22%), Positives = 53/140 (38%), Gaps = 18/140 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGRHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTV 1147
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTV 231
>sp|P0DN70|ADPRH_STRPG Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M5 (strain Manfredo) OX=160491 GN=SpyM50868
PE=1 SV=1
Length=270
Score = 80.9 bits (198), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/142 (22%), Positives = 53/142 (37%), Gaps = 18/142 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGRHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTVRT 1149
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTVLK 233
>sp|O67112|Y987_AQUAE Uncharacterized protein aq_987 OS=Aquifex
aeolicus (strain VF5) OX=224324 GN=aq_987 PE=4 SV=1
Length=165
Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats.
Identities = 30/168 (18%), Positives = 61/168 (36%), Gaps = 26/168 (15%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
++ + I + + VIVN AN GGGVA + + +++E+ + P
Sbjct 2 DIKVVKGSITE----VDADVIVNPANSRGLMGGGVAVVIKRLGGEEIEREAVE----KAP 53
Query 1075 LTVGGSCLLSGHNLA-KKCLHVVGPNLNAGEDIQLLKAAYENFN---------SQDILLA 1124
+ VG + L + L K +H P + + + I+
Sbjct 54 IPVGSAVLTTAGKLKFKGVIHA--PTMEEPAMPSSEEKVRKATRAALELADKECFKIVAI 111
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNL 1172
P + G+ G + + V+ +R + E+V++ +D
Sbjct 112 PGMGTGVGGVPKEVAARAMVEEIRK------FEPKCLEKVILVDIDEE 153
>sp|Q5JER1|Y1890_THEKO Uncharacterized protein TK1890 OS=Thermococcus
kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OX=69014 GN=TK1890 PE=4 SV=1
Length=180
Score = 78.6 bits (192), Expect = 1e-14, Method: Composition-based stats.
Identities = 42/179 (23%), Positives = 70/179 (39%), Gaps = 32/179 (18%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKE---SDD-YIK 1070
I DI + IVNAAN +L+HGGGVA A+ KA G ++ S + +
Sbjct 3 EFEIVKGDITR----FPAEAIVNAANRYLEHGGGVAYAIAKAAAGDPREYIRISKEAMRE 58
Query 1071 LNGP--LTVGGSCLLSGHNLAKK----CLHVVGP----NLNAGEDIQLLKAAYENFNSQ- 1119
G + G + L K +H VGP + + +L KA
Sbjct 59 QLGKDHIEHGEVVVTPAMRLEKHGIRYVIHTVGPYCGGIWDEDKKEKLRKAILGALRKAE 118
Query 1120 ----DILLAPLLSAGIFGAKPLQSLQVCVQTVR---------TQVYIAVNDKALYEQVV 1165
+ P +SAGI+G + ++ + + +VY+ + + YE+ +
Sbjct 119 ELGVKTIAFPAVSAGIYGCPLEEVVKTFKEVIDEFEREAGSVERVYLVLYSEKDYERAL 177
>sp|P0DC29|ADPRH_STRPQ Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M3 (strain SSI-1) OX=193567 GN=SPs1056
PE=3 SV=1
Length=270
Score = 80.9 bits (198), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/140 (22%), Positives = 53/140 (38%), Gaps = 18/140 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTV 1147
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTV 231
>sp|P0DC28|ADPRH_STRP3 Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
OX=198466 GN=SpyM3_0856 PE=3 SV=1
Length=270
Score = 80.9 bits (198), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/140 (22%), Positives = 53/140 (38%), Gaps = 18/140 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFIPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTV 1147
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTV 231
>sp|Q99ZI6|ADPRH_STRP1 Protein-ADP-ribose hydrolase OS=Streptococcus
pyogenes serotype M1 OX=301447 GN=SPy_1216 PE=3 SV=1
Length=270
Score = 80.9 bits (198), Expect = 1e-14, Method: Composition-based stats.
Identities = 31/140 (22%), Positives = 53/140 (38%), Gaps = 18/140 (13%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN L G + A++ ++ + G +G
Sbjct 92 DIRYLAVDAIVNAANSELLGCFSPNHGCIDNAIHTFAGSRLRLACQAIMTEQGRKEAIGQ 151
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAGEDIQ-----LLKAAYENFN------SQDILLAPLL 1127
+ L S ++L A +H VGP + G + LL Y + L +
Sbjct 152 AKLTSAYHLPASYIIHTVGPRITKGHHVSPIRADLLARCYRSSLDLAVKAGLTSLAFCSI 211
Query 1128 SAGIFGAKPLQSLQVCVQTV 1147
S G FG ++ Q+ ++TV
Sbjct 212 STGEFGFPKKEAAQIAIKTV 231
>sp|Q8BCR0|POLN_RUBVN Non-structural polyprotein p200 OS=Rubella
virus (strain RN-UK86) OX=376267 PE=3 SV=1
Length=2116
Score = 84.4 bits (207), Expect = 3e-14, Method: Composition-based stats.
Identities = 42/169 (25%), Positives = 63/169 (37%), Gaps = 17/169 (10%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKC 1092
V+VNAAN L G GV GA+ A+ + P G + GH
Sbjct 835 VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPTGEAVATPGHGCGYTHI 890
Query 1093 LHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPLQSLQ 1141
+H V P E LL+ AY + PLL AG++G +SL+
Sbjct 891 IHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAAESLR 950
Query 1142 VCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+ RT+ V+ ++ + + L A ++ PP TE
Sbjct 951 AALAATRTEPAERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|P67344|ADPRH_STAAN Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain N315) OX=158879 GN=SA0314 PE=1 SV=1
Length=266
Score = 79.4 bits (194), Expect = 3e-14, Method: Composition-based stats.
Identities = 34/154 (22%), Positives = 63/154 (41%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENF----- 1116
I+ G VG + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKKTRGYNLPAKYIIHTVGPQIRRLPVSKMNQDLLAKCYLSCLKLAD 199
Query 1117 -NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+S + + +S G+F ++ ++ V+TV +
Sbjct 200 QHSLNHVAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|P67343|ADPRH_STAAM Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain Mu50 / ATCC 700699) OX=158878 GN=SAV0325
PE=1 SV=1
Length=266
Score = 79.4 bits (194), Expect = 3e-14, Method: Composition-based stats.
Identities = 34/154 (22%), Positives = 63/154 (41%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENF----- 1116
I+ G VG + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKKTRGYNLPAKYIIHTVGPQIRRLPVSKMNQDLLAKCYLSCLKLAD 199
Query 1117 -NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+S + + +S G+F ++ ++ V+TV +
Sbjct 200 QHSLNHVAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|P13889|POLN_RUBVT Non-structural polyprotein p200 OS=Rubella
virus (strain Therien) OX=11045 PE=3 SV=5
Length=2116
Score = 84.0 bits (206), Expect = 4e-14, Method: Composition-based stats.
Identities = 50/233 (21%), Positives = 80/233 (34%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
+ + L+ E S P+ + + Y + V ++ DI+
Sbjct 775 PAGPADRARDAELEVACEPSGPPTSTRADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ P G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAANCRRLA----PCPTGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPL 1137
+H V P E LL+ AY + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAA 946
Query 1138 QSLQVCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+SL+ + RT+ V+ ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRTEPVERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|P27283|POLN_SINDO Polyprotein P1234 OS=Sindbis virus subtype
Ockelbo (strain Edsbyn 82-5) OX=31699 PE=3 SV=2
Length=2515
Score = 83.6 bits (205), Expect = 4e-14, Method: Composition-based stats.
Identities = 45/191 (24%), Positives = 70/191 (37%), Gaps = 28/191 (15%)
Query 1025 KEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLS 1084
+ +VNAAN + G GV A+ K + + + G + L
Sbjct 1356 ENIADCQEEAVVNAANPLGRPGEGVCRAIYKRWPNSFTDSATE---------TGTAKLTV 1406
Query 1085 GHNLAKKCLHVVGPNLNAG---EDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAK 1135
H KK +H VGP+ E ++LL+ AY N ++ + PLLS GI+ A
Sbjct 1407 CH--GKKVIHAVGPDFRKHPEAEALKLLQNAYHAVADLVNEHNIKSVAIPLLSTGIYAAG 1464
Query 1136 PLQ------SLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+ L + V I DK E++ D + LK V K E+ ++
Sbjct 1465 KDRLEVSLNCLTTALDRTDADVTIYCLDKKWKERI--DAVLQLKESVTELKDEDMEIDDE 1522
Query 1190 SKTEEKSVVQK 1200
K
Sbjct 1523 LVWIHPDSCLK 1533
>sp|P03317|POLN_SINDV Polyprotein P1234 OS=Sindbis virus OX=11034
PE=1 SV=2
Length=2513
Score = 83.6 bits (205), Expect = 5e-14, Method: Composition-based stats.
Identities = 44/191 (23%), Positives = 69/191 (36%), Gaps = 28/191 (15%)
Query 1025 KEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLS 1084
+ +VNAAN + G GV A+ K + + + G + +
Sbjct 1356 ENIADCQEEAVVNAANPLGRPGEGVCRAIYKRWPTSFTDSATE---------TGTARMTV 1406
Query 1085 GHNLAKKCLHVVGPNLNAG---EDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAK 1135
L KK +H VGP+ E ++LL+ AY N ++ + PLLS GI+ A
Sbjct 1407 C--LGKKVIHAVGPDFRKHPEAEALKLLQNAYHAVADLVNEHNIKSVAIPLLSTGIYAAG 1464
Query 1136 PLQ------SLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+ L + V I DK E++ D LK V K E+ ++
Sbjct 1465 KDRLEVSLNCLTTALDRTDADVTIYCLDKKWKERI--DAALQLKESVTELKDEDMEIDDE 1522
Query 1190 SKTEEKSVVQK 1200
K
Sbjct 1523 LVWIHPDSCLK 1533
>sp|Q93RG0|ADPRH_TREMD Protein-ADP-ribose hydrolase OS=Treponema
medium OX=58231 PE=3 SV=1
Length=261
Score = 79.0 bits (193), Expect = 5e-14, Method: Composition-based stats.
Identities = 27/140 (19%), Positives = 50/140 (36%), Gaps = 16/140 (11%)
Query 1026 EAQSANPMVIVNAANIHLKH-----GGGVAGALNKATNGAMQKESDDYIKLNG-PLTVGG 1079
+ + IVNAAN + + ++ ++ ++ G G
Sbjct 93 DITTLKVDAIVNAANSGMTGCWQPCHACIDNCIHTFAGVQLRTVCAGIMQEQGHEEPTGT 152
Query 1080 SCLLSGHNL-AKKCLHVVGPNLNAG---EDIQLLKAAYENF------NSQDILLAPLLSA 1129
+ + NL K LH VGP ++ D LL +Y + N + +S
Sbjct 153 AKITPAFNLPCKYVLHTVGPIISGQLTDRDCTLLANSYTSCLNLAAENGVKSIAFCCIST 212
Query 1130 GIFGAKPLQSLQVCVQTVRT 1149
G+F ++ ++ V TV
Sbjct 213 GVFRFPAQKAAEIAVATVED 232
>sp|Q7TZB9|Y1934_MYCBO Uncharacterized protein Mb1934c OS=Mycobacterium
bovis (strain ATCC BAA-935 / AF2122/97) OX=233413
GN=lppD PE=4 SV=1
Length=358
Score = 80.5 bits (197), Expect = 5e-14, Method: Composition-based stats.
Identities = 32/142 (23%), Positives = 55/142 (39%), Gaps = 15/142 (11%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + D+ K A I NAAN L+H GGVA A+ +A +Q+ES + P
Sbjct 190 ELEVHQADVTKLELDA----ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAP 241
Query 1075 LTVGGSCLLSGHN-LAKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQDILLAPLL 1127
+ +G + + + A+ +H L +++ AA L
Sbjct 242 IGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSLALVAF 301
Query 1128 SAGIFGAKPLQSLQVCVQTVRT 1149
G+ G + ++ V VR
Sbjct 302 GTGVGGFPLDDAARLMVGAVRR 323
>sp|P9WK29|Y1899_MYCTU Uncharacterized protein Rv1899c OS=Mycobacterium
tuberculosis (strain ATCC 25618 / H37Rv) OX=83332
GN=Rv1899c PE=1 SV=1
Length=359
Score = 80.5 bits (197), Expect = 5e-14, Method: Composition-based stats.
Identities = 32/142 (23%), Positives = 55/142 (39%), Gaps = 15/142 (11%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + D+ K A I NAAN L+H GGVA A+ +A +Q+ES + P
Sbjct 191 ELEVHQADVTKLELDA----ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAP 242
Query 1075 LTVGGSCLLSGHN-LAKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQDILLAPLL 1127
+ +G + + + A+ +H L +++ AA L
Sbjct 243 IGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSLALVAF 302
Query 1128 SAGIFGAKPLQSLQVCVQTVRT 1149
G+ G + ++ V VR
Sbjct 303 GTGVGGFPLDDAARLMVGAVRR 324
>sp|P9WK28|Y1899_MYCTO Uncharacterized protein MT1950 OS=Mycobacterium
tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT1950
PE=4 SV=1
Length=374
Score = 80.5 bits (197), Expect = 6e-14, Method: Composition-based stats.
Identities = 32/142 (23%), Positives = 55/142 (39%), Gaps = 15/142 (11%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ + D+ K A I NAAN L+H GGVA A+ +A +Q+ES + P
Sbjct 206 ELEVHQADVTKLELDA----ITNAANTRLRHAGGVAAAIARAGGPELQRESTE----KAP 257
Query 1075 LTVGGSCLLSGHN-LAKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQDILLAPLL 1127
+ +G + + + A+ +H L +++ AA L
Sbjct 258 IGLGEAVETTAGDMPARYVIHAATMELGGPTSGEIITAATAATLRKADELGCRSLALVAF 317
Query 1128 SAGIFGAKPLQSLQVCVQTVRT 1149
G+ G + ++ V VR
Sbjct 318 GTGVGGFPLDDAARLMVGAVRR 339
>sp|O75367|H2AY_HUMAN Core histone macro-H2A.1 OS=Homo sapiens
OX=9606 GN=MACROH2A1 PE=1 SV=5
Length=369
Score = 80.5 bits (197), Expect = 7e-14, Method: Composition-based stats.
Identities = 38/178 (21%), Positives = 66/178 (37%), Gaps = 13/178 (7%)
Query 1007 TGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD 1066
T L L + + DI S + +V+ N GG V L K +
Sbjct 188 TKSLFLGQKLQVVQADIA----SIDSDAVVHPTNTDFYIGGEVGNTLEKKGGKEFVEAVL 243
Query 1067 DYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQ 1119
+ K NGPL V G+ + +GH L AK +H P A + +LL+ +N
Sbjct 244 ELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDKKL 303
Query 1120 DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+ P + +G G + Q+ ++ + + Y + + V D+ +
Sbjct 304 KSIAFPSIGSGRNGFPKQTAAQLILKAISS--YFVSTMSSSIKTVYFVLFDSESIGIY 359
>sp|Q02874|H2AY_RAT Core histone macro-H2A.1 OS=Rattus norvegicus
OX=10116 GN=Macroh2a1 PE=1 SV=5
Length=368
Score = 80.5 bits (197), Expect = 7e-14, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 71/203 (35%), Gaps = 12/203 (6%)
Query 985 TTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAI---KCVDIVKEAQSANPMVIVNAANI 1041
+ +Q E+ G+ L+ K + + S + +V+ N
Sbjct 158 SKKQGEVSKAASADSTTEGAPTDGFTVLSTKSLFLGQKLQVVQADIASIDSDAVVHPTNA 217
Query 1042 HLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNL 1100
GG V L K + + K NGPL V G+ + +GH L AK +H P
Sbjct 218 DFYIGGEVGSTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVW 277
Query 1101 NAGEDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIA 1154
A + +LL+ +N + P + +G G + Q+ ++ + + Y
Sbjct 278 GADKCEELLEKTVKNCLALADDRKLKSIAFPSIGSGRNGFPKQTAAQLILKAISS--YFV 335
Query 1155 VNDKALYEQVVMDYLDNLKPRVE 1177
+ + V D+ +
Sbjct 336 STMSSSIKTVYFVLFDSESIGIY 358
>sp|Q6GJZ1|ADPRH_STAAR Protein-ADP-ribose hydrolase OS=Staphylococcus
aureus (strain MRSA252) OX=282458 GN=SAR0322 PE=3 SV=1
Length=266
Score = 78.6 bits (192), Expect = 7e-14, Method: Composition-based stats.
Identities = 33/154 (21%), Positives = 62/154 (40%), Gaps = 23/154 (15%)
Query 1014 DNVAIKCVDIVKEAQSANPMVIVNAANIHLK------HGGGVAGALNKATNGAMQKESDD 1067
DN+ + DI + IVNAAN H + ++ ++ + +
Sbjct 85 DNIFVWQGDIT----TLKIDAIVNAANSRFLGCMQANHDC-IDNIIHTKAGVQVRLDCAE 139
Query 1068 YIKLNGPLT-VGGSCLLSGHNL-AKKCLHVVGPNLN----AGEDIQLLKAAYENFNSQ-- 1119
I+ G VG + + G+NL AK +H VGP + + + LL Y +
Sbjct 140 IIRQQGRNEGVGKAKITRGYNLPAKYIIHTVGPQIRRLPVSKLNQDLLAKCYLSCLKLAD 199
Query 1120 ----DILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+ + +S G+F ++ ++ V+TV +
Sbjct 200 QQSLNHIAFCCISTGVFAFPQDEAAEIAVRTVES 233
>sp|Q9QZQ8|H2AY_MOUSE Core histone macro-H2A.1 OS=Mus musculus
OX=10090 GN=Macroh2a1 PE=1 SV=4
Length=369
Score = 80.1 bits (196), Expect = 8e-14, Method: Composition-based stats.
Identities = 38/178 (21%), Positives = 66/178 (37%), Gaps = 13/178 (7%)
Query 1007 TGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD 1066
T L L + + DI S + +V+ N GG V L K +
Sbjct 188 TKSLFLGQKLQVVQADIA----SIDSDAVVHPTNTDFYTGGEVGNTLEKKGGKEFVEAVL 243
Query 1067 DYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQ 1119
+ K NGPL V G+ + +GH L AK +H P A + +LL+ +N
Sbjct 244 ELRKKNGPLEVAGAAISAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDRKL 303
Query 1120 DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+ P + +G G + Q+ ++ + + Y + + V D+ +
Sbjct 304 KSIAFPSIGSGRNGFPKQTAAQLILKAISS--YFVSTMSSSIKTVYFMLFDSESIGIY 359
>sp|A7T167|GDAP2_NEMVE Protein GDAP2 homolog OS=Nematostella vectensis
OX=45351 GN=gdap2 PE=3 SV=1
Length=502
Score = 81.3 bits (199), Expect = 9e-14, Method: Composition-based stats.
Identities = 44/248 (18%), Positives = 81/248 (33%), Gaps = 22/248 (9%)
Query 968 AETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEA 1027
T + + T + E ++ F ++ V + DI K A
Sbjct 5 GATANLVDINSLPKWSTTPVPNYEPGSNESQSSSFLSPFPVDEEINAKVVLWNGDITKLA 64
Query 1028 QSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHN 1087
IVN N L G ++ +++A + +E +L G G + + G+N
Sbjct 65 ----ADAIVNTTNESLSDRGALSERVHRAAGPELMQECRQ--QLLG-CRTGEAKISEGYN 117
Query 1088 L-AKKCLHVVGPNLN---AGEDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPL 1137
L A+ +H VGP N L + Y N N + +++ G P
Sbjct 118 LPARYVIHTVGPRYNTKYKTAAESALFSCYRNTMRLVRENKISTIGVCVVNTTKRGYPPE 177
Query 1138 QSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSV 1197
+ ++TVR + + + ++ V K D E ++
Sbjct 178 DGAHIALRTVRRFLEKYGSAVD-----TVAFVVEGAEAVVYAKVMPIYFPRDKLEEAHAL 232
Query 1198 VQKPVDVK 1205
P D+
Sbjct 233 TLMPDDIG 240
>sp|O93327|H2AY_CHICK Core histone macro-H2A.1 OS=Gallus gallus
OX=9031 GN=MACROH2A1 PE=1 SV=4
Length=369
Score = 79.8 bits (195), Expect = 1e-13, Method: Composition-based stats.
Identities = 35/178 (20%), Positives = 66/178 (37%), Gaps = 13/178 (7%)
Query 1007 TGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD 1066
T L L + + DI + + +V+ N GG V L K +
Sbjct 188 TKSLFLGQKLQVVQADIA----TIDSDAVVHPTNSDFYTGGEVGSTLEKKGGKEFVEAVI 243
Query 1067 DYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENF------NSQ 1119
+ K NGPL + G+ + +GH L AK +H P + + +LL+ +N
Sbjct 244 ELRKKNGPLDIAGAVVSAGHGLPAKFVIHCNSPGWGSDKCEELLEKTVKNCLALADEKKL 303
Query 1120 DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVE 1177
+ P + +G G + Q+ ++ + + Y + + V D+ +
Sbjct 304 KSIAFPSIGSGRNGFPKQTAAQLILKAISS--YFVSTMSSSIKTVYFVLFDSESIGIY 359
>sp|P13896|POLN_WEEV Polyprotein P1234 OS=Western equine encephalitis
virus OX=11039 PE=3 SV=3
Length=2467
Score = 82.5 bits (202), Expect = 1e-13, Method: Composition-based stats.
Identities = 51/195 (26%), Positives = 73/195 (37%), Gaps = 33/195 (17%)
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ DI K A A IVNAAN + G GV GAL + A P+ V
Sbjct 1333 VIRGDISKSADQA----IVNAANSKGQPGSGVCGALYRKWPAAF---------DRQPIAV 1379
Query 1078 GGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLS 1128
G + L+ L +H VGPN + + + L AAY N + PLLS
Sbjct 1380 GTARLVKHEPL---IIHAVGPNFSKMPEPEGDLKLAAAYMSIASIVNAERITKISVPLLS 1436
Query 1129 AGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE 1182
GI+ + L L T V I DK +++ + K VE +
Sbjct 1437 TGIYSGGKDRVMQSLHHLFTAFDTTDADVTIYCLDKQWETRIIEAI--HRKESVEILDDD 1494
Query 1183 EPPNTEDSKTEEKSV 1197
+P + + + S
Sbjct 1495 KPVDIDLVRVHPNSS 1509
>sp|Q5XXP4|POLN_CHIK3 Polyprotein P1234 OS=Chikungunya virus (strain
37997) OX=371095 PE=1 SV=1
Length=2474
Score = 81.7 bits (200), Expect = 2e-13, Method: Composition-based stats.
Identities = 39/168 (23%), Positives = 62/168 (37%), Gaps = 30/168 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ +K +DI K + +VNAAN G GV A+ K ES
Sbjct 1333 CAPSYRVKRMDIAKN----DEECVVNAANPRGLPGDGVCKAVYKK-----WPESF----K 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENFNSQ------DIL 1122
N VG + + +H VGPN + + + L AAY + + +
Sbjct 1380 NSATPVGTAKTVMCGTYP--VIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSV 1437
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
PLLS G++ + L L + + V I DK +++
Sbjct 1438 AIPLLSTGVYSGGKDRLTQSLNHLFTALDSTDADVVIYCRDKEWEKKI 1485
>sp|Q4QXJ8|POLN_EEEVF Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain Florida 91-469) OX=374598 PE=1 SV=3
Length=2494
Score = 81.3 bits (199), Expect = 3e-13, Method: Composition-based stats.
Identities = 45/162 (28%), Positives = 61/162 (38%), Gaps = 31/162 (19%)
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ DI K N VIVNAAN + G GV GAL + GA K P+
Sbjct 1333 VVRGDITKS----NDEVIVNAANNKGQPGSGVCGALYRKWPGAFDK---------QPVAT 1379
Query 1078 GGSCLLSGHNLAKKCLHVVGPNL---NAGEDIQLLKAAYE------NFNSQDILLAPLLS 1128
G + L+ + +H VGPN + E Q L Y N + PLLS
Sbjct 1380 GKAHLV---KHSPNVIHAVGPNFSRLSENEGDQKLSEVYMDIARIINNERFTKVSIPLLS 1436
Query 1129 AGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
GI+ + L L + T + I DK ++
Sbjct 1437 TGIYAGGKDRVMQSLNHLFTAMDTTDADITIYCLDKQWESRI 1478
>sp|Q8JUX6|POLN_CHIKS Polyprotein P1234 OS=Chikungunya virus (strain
S27-African prototype) OX=371094 PE=1 SV=1
Length=2474
Score = 80.9 bits (198), Expect = 3e-13, Method: Composition-based stats.
Identities = 39/168 (23%), Positives = 62/168 (37%), Gaps = 30/168 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ +K +DI K + +VNAAN G GV A+ K ES
Sbjct 1333 CAPSYRVKRMDIAKN----DEECVVNAANPRGLPGDGVCKAVYKK-----WPESF----K 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENFNSQ------DIL 1122
N VG + + +H VGPN + + + L AAY + + +
Sbjct 1380 NSATPVGTAKTVMCGTYP--VIHAVGPNFSNYSESEGDRELAAAYREVAKEVTRLGVNSV 1437
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
PLLS G++ + L L + + V I DK +++
Sbjct 1438 AIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKI 1485
>sp|Q6X2U2|POLN_RUBVC Non-structural polyprotein p200 OS=Rubella
virus (strain BRDII) OX=376263 PE=3 SV=1
Length=2116
Score = 80.9 bits (198), Expect = 3e-13, Method: Composition-based stats.
Identities = 41/170 (24%), Positives = 65/170 (38%), Gaps = 17/170 (10%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKC 1092
V+VNAAN L G GV GA+ + ++ ++ P G + GH
Sbjct 835 VVVNAANEGLLAGSGVCGAIFASAAASLAEDCRRLA----PCPTGEAVATPGHGCGYAHI 890
Query 1093 LHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPLQSLQ 1141
+H V P + LL+ AY + PLL AGI+G +SL+
Sbjct 891 IHAVAPRRPQDPAALEQSEALLERAYRSIVALAAARRWTCVACPLLGAGIYGWSAAESLR 950
Query 1142 VCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTEDS 1190
+ RT+ V+ ++ + + L A ++ PP TE
Sbjct 951 AALAAARTEPAERVSLHICHPDRATLMHASVLVGAGLAARRVSPPPTEPP 1000
>sp|O40955|POLN_RUBVR Non-structural polyprotein p200 OS=Rubella
virus (strain RA27/3 vaccine) OX=11044 PE=1 SV=1
Length=2116
Score = 80.5 bits (197), Expect = 4e-13, Method: Composition-based stats.
Identities = 50/233 (21%), Positives = 84/233 (36%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
+ + + L+ E S + P+ + + Y + V ++ DI+
Sbjct 775 SAGPADRARDAELEVAYEPSGPPTSTKADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ + P G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPTGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYENFNSQDILLA------PLLSAGIFGAKPL 1137
+H V P E LL+ AY + + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWARVACPLLGAGVYGWSAA 946
Query 1138 QSLQVCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+SL+ + RT+ V+ ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRTEPAERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|Q86924|POLN_AURAV Polyprotein P1234 OS=Aura virus OX=44158
PE=3 SV=3
Length=2499
Score = 80.1 bits (196), Expect = 6e-13, Method: Composition-based stats.
Identities = 39/149 (26%), Positives = 60/149 (40%), Gaps = 26/149 (17%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAK 1090
+VNAAN K G GV A+ K + + + + V + + HN K
Sbjct 1360 TEEAVVNAANARGKPGDGVCRAIFKKWPKSFENATTE---------VETAVMKPCHN--K 1408
Query 1091 KCLHVVGPNLNAG---EDIQLLKAAY----ENFNSQDI--LLAPLLSAGIFGAK------ 1135
+H VGP+ E +LL+ AY + N + I + PLLS GI+ A
Sbjct 1409 VVIHAVGPDFRKYTLEEATKLLQNAYHDVAKIVNEKGISSVAIPLLSTGIYAAGADRLDL 1468
Query 1136 PLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L+ L + V I DK +++
Sbjct 1469 SLRCLFTALDRTDADVTIYCLDKKWEQRI 1497
>sp|Q6X2U4|POLN_RUBVB Non-structural polyprotein p200 OS=Rubella
virus (strain BRD1) OX=376262 PE=3 SV=1
Length=2116
Score = 79.8 bits (195), Expect = 7e-13, Method: Composition-based stats.
Identities = 30/112 (27%), Positives = 42/112 (38%), Gaps = 16/112 (14%)
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKC 1092
V+VNAAN L G GV GA+ + + ++ P G + GH
Sbjct 835 VVVNAANEGLLAGSGVCGAIFASAAATLAEDCRRLA----PCPTGEAVATPGHGCGYTHI 890
Query 1093 LHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFG 1133
+H V P + LL+ AY + PLL AGI+G
Sbjct 891 IHAVAPRRPQDPAALEQSEALLERAYRSVVALAAARRWACVACPLLGAGIYG 942
>sp|O90368|POLN_ONNVS Polyprotein P1234 OS=O'nyong-nyong virus
(strain SG650) OX=374989 PE=1 SV=1
Length=2513
Score = 79.4 bits (194), Expect = 1e-12, Method: Composition-based stats.
Identities = 36/169 (21%), Positives = 59/169 (35%), Gaps = 30/169 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ +K +DI K +VNAAN G GV A+ + ES
Sbjct 1333 CAPSYRVKRMDIAKN----TEECVVNAANPRGVPGDGVCKAVYRK-----WPESF----R 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENFNSQ------DIL 1122
N VG + + +H VGPN + + + L + Y + +
Sbjct 1380 NSATPVGTAKTIMCGQYP--VIHAVGPNFSNYSEAEGDRELASVYREVAKEVSRLGVSSV 1437
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVV 1165
PLLS G++ + L L + + V I DK +++
Sbjct 1438 AIPLLSTGVYSGGKDRLLQSLNHLFTAMDSTDADVVIYCRDKEWEKKIT 1486
>sp|O90370|POLN_ONNVI Polyprotein P1234 OS=O'nyong-nyong virus
(strain Igbo Ora) OX=79899 PE=3 SV=1
Length=2513
Score = 79.4 bits (194), Expect = 1e-12, Method: Composition-based stats.
Identities = 37/169 (22%), Positives = 60/169 (36%), Gaps = 30/169 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ +K +DI K +VNAAN G GV A+ + ES
Sbjct 1333 CAPSYRVKRMDIAKN----TEECVVNAANPRGVPGDGVCKAVYRK-----WPESF----R 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENFNSQ------DIL 1122
N VG + + +H VGPN + + + L +AY + +
Sbjct 1380 NSATPVGTAKTIMCGQYP--VIHAVGPNFSNYSEAEGDRELASAYREVAKEVSRLGVSSV 1437
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVV 1165
PLLS G++ + L L + + V I DK +++
Sbjct 1438 AIPLLSTGVYSGGKDRLLQSLNHLFAAMDSTDADVVIYCRDKEWEKKIT 1486
>sp|P13886|POLN_ONNVG Polyprotein P1234 OS=O'nyong-nyong virus
(strain Gulu) OX=11028 PE=3 SV=2
Length=2514
Score = 78.6 bits (192), Expect = 2e-12, Method: Composition-based stats.
Identities = 36/169 (21%), Positives = 59/169 (35%), Gaps = 30/169 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
+ +K +DI K +VNAAN G GV A+ + ES
Sbjct 1333 CAPSYRVKRMDIAKN----TEECVVNAANPRGVPGDGVCKAVYRK-----WPESF----R 1379
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENFNSQ------DIL 1122
N VG + + +H VGPN + + + L + Y + +
Sbjct 1380 NSATPVGTAKTIMCGQYP--VIHAVGPNFSNYSEAEGDRELASVYREVAKEVSRLGVSSV 1437
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVV 1165
PLLS G++ + L L + + V I DK +++
Sbjct 1438 AIPLLSTGVYSGGKDRLLQSLNHLFAAMDSTDADVVIYCRDKEWEKKIT 1486
>sp|Q306W6|POLN_EEEV1 Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain PE-0.0155) OX=374596 PE=1 SV=3
Length=2471
Score = 78.2 bits (191), Expect = 2e-12, Method: Composition-based stats.
Identities = 51/201 (25%), Positives = 80/201 (40%), Gaps = 33/201 (16%)
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ DI K VIVNAAN + G GV GAL K GA K P+
Sbjct 1333 VIRGDISKSTD----EVIVNAANNKGQPGAGVCGALYKKWPGAFDKA---------PIAT 1379
Query 1078 GGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAY----ENFNS--QDILLAPLLS 1128
G + L+ +H VGPN + +++ L Y + N + + PLLS
Sbjct 1380 GTAHLVKH---TPNIIHAVGPNFSRMSEVEGNQKLSEVYMDIAKIINKERYNKVSIPLLS 1436
Query 1129 AGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE 1182
G++ + L L + T V I DK +E + D + + E + +
Sbjct 1437 TGVYAGGKDRVMQSLNHLFTAMDTTDADVTIYCLDKQ-WETRIKDAIARKESVEELVEDD 1495
Query 1183 EPPNTEDSKTE-EKSVVQKPV 1202
+P + E + + S+V +P
Sbjct 1496 KPVDIELVRVHPQSSLVGRPG 1516
>sp|Q306W8|POLN_EEEV8 Polyprotein P1234 OS=Eastern equine encephalitis
virus (strain PE-3.0815) OX=374597 PE=1 SV=3
Length=2474
Score = 78.2 bits (191), Expect = 2e-12, Method: Composition-based stats.
Identities = 44/157 (28%), Positives = 59/157 (38%), Gaps = 31/157 (20%)
Query 1018 IKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTV 1077
+ DI K A IVNAAN + G GV GAL K GA K P+
Sbjct 1333 VIRGDISKSTDEA----IVNAANNKGQPGAGVCGALYKKWPGAFDK---------VPIAT 1379
Query 1078 GGSCLLSGHNLAKKCLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLS 1128
G + L+ +H VGPN + +++ L Y N + + PLLS
Sbjct 1380 GTAHLVKH---TPNIIHAVGPNFSRVSEVEGNQKLSEVYMDIAKIINRERYNKVSIPLLS 1436
Query 1129 AGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKA 1159
GI+ + L L + T V I DK
Sbjct 1437 TGIYAGGKDRVMQSLNHLFTAMDTTDADVTIYCLDKQ 1473
>sp|Q99IE5|POLN_RUBVV Non-structural polyprotein p200 OS=Rubella
virus (strain TO-336) OX=376264 PE=3 SV=1
Length=2116
Score = 77.1 bits (188), Expect = 4e-12, Method: Composition-based stats.
Identities = 49/233 (21%), Positives = 82/233 (35%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
+ + L+ E S+ + P+ + + Y + V ++ DI+
Sbjct 775 SAGPADRARHAELEVAYEPSDPPTPTKADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ + P G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPTGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPL 1137
+H V P E LL+ AY + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAA 946
Query 1138 QSLQVCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+SL+ + R + V+ ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRAEPAERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|Q99IE7|POLN_RUBVO Non-structural polyprotein p200 OS=Rubella
virus (strain TO-336 vaccine) OX=376265 PE=3 SV=1
Length=2116
Score = 77.1 bits (188), Expect = 4e-12, Method: Composition-based stats.
Identities = 49/233 (21%), Positives = 82/233 (35%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
+ + L+ E S+ + P+ + + Y + V ++ DI+
Sbjct 775 SAGPADRARHAELEVAYEPSDPPTPTKADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ + P G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPTGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPL 1137
+H V P E LL+ AY + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWACVACPLLGAGVYGWSAA 946
Query 1138 QSLQVCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+SL+ + R + V+ ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRAEPAERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|P87515|POLN_BFV Polyprotein P1234 OS=Barmah forest virus OX=11020
PE=3 SV=3
Length=2411
Score = 76.7 bits (187), Expect = 6e-12, Method: Composition-based stats.
Identities = 35/154 (23%), Positives = 52/154 (34%), Gaps = 26/154 (17%)
Query 1026 EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
+ +A +VNAAN G GV GA+ + A G + S
Sbjct 1341 DISNAPEDAVVNAANQQGVKGAGVCGAIYRKWPDAFGD---------VATPTGTAV--SK 1389
Query 1086 HNLAKKCLHVVGPNLNAGEDIQ---LLKAAYENF------NSQDILLAPLLSAGIFGA-- 1134
K +H VGPN + + + L +AY + PLLS GI+
Sbjct 1390 SVQDKLVIHAVGPNFSKCSEEEGDRDLASAYRAAAEIVMDKKITTVAVPLLSTGIYAGGK 1449
Query 1135 ----KPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
+ L L V I DK +++
Sbjct 1450 NRVEQSLNHLFTAFDNTDADVTIYCMDKTWEKKI 1483
>sp|Q6QLN1|POLN_AHEV Non-structural polyprotein pORF1 OS=Avian
hepatitis E virus (isolate Chicken/California/Meng) OX=516993
GN=ORF1 PE=3 SV=1
Length=1531
Score = 75.5 bits (184), Expect = 1e-11, Method: Composition-based stats.
Identities = 40/176 (23%), Positives = 63/176 (36%), Gaps = 12/176 (7%)
Query 986 TEQSEIEPEPEPTPE---EPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIH 1042
E SE +P PT E P+ G ++ + IV +VN AN
Sbjct 588 PEVSESQPGLTPTREVTNMPLPPQRGQEEVLAVLPSGARVIVGNLLDVAADWLVNPANRD 647
Query 1043 LKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPNLNA 1102
+ GGG+ G ++ + + L G G K +H GP+
Sbjct 648 HQPGGGLCGMFHRRW-PHLWPVCGEV----QDLPTGPVIFQQG---PPKVIHAPGPDYRI 699
Query 1103 GEDIQLLKAAYENFNS-QDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVND 1157
D L+ Y + + +PL+SAGI+ A +S + T R + V
Sbjct 700 KPDPDGLRRVYAVVHQAHGTVASPLISAGIYRAPARESFEAWAATARDGDLLVVQR 755
>sp|P13888|POLN_RRVT Polyprotein nsP1234 (Fragment) OS=Ross river
virus (strain T48) OX=11032 PE=1 SV=2
Length=1149
Score = 75.5 bits (184), Expect = 1e-11, Method: Composition-based stats.
Identities = 38/148 (26%), Positives = 59/148 (40%), Gaps = 26/148 (18%)
Query 1032 PMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK 1091
+VNAAN G GV A+ + K D + VG + L+ + +
Sbjct 16 EEAVVNAANAKGTVGDGVCRAVAR-------KWPDSF--KGAATPVGTAKLVQANGM--N 64
Query 1092 CLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA------KP 1136
+H VGPN + + + L AAY N ++ + PLLS G+F +
Sbjct 65 VIHAVGPNFSTVTEAEGDRELAAAYRAVAGIINASNIKSVAIPLLSTGVFSGGKDRVMQS 124
Query 1137 LQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L L + T V I DKA +++
Sbjct 125 LNHLFTAMDTTDADVVIYCRDKAWEKKI 152
>sp|Q9J6K9|POLN_RUBVD Non-structural polyprotein p200 OS=Rubella
virus (strain Cendehill) OX=376266 PE=3 SV=2
Length=2116
Score = 75.1 bits (183), Expect = 2e-11, Method: Composition-based stats.
Identities = 48/233 (21%), Positives = 76/233 (33%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
+ + L+ E S + P+ + + Y + V ++ DI+
Sbjct 775 PAEPADRARDAELEVAYEPSGPPTSTKADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ + P G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPTGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYE------NFNSQDILLAPLLSAGIFGAKPL 1137
+H V P E LL+ AY + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWAYVACPLLGAGVYGWSAA 946
Query 1138 QS-LQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+S T V ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRAEPVERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|P13887|POLN_RRVN Polyprotein P1234 OS=Ross river virus (strain
NB5092) OX=11031 PE=3 SV=2
Length=2480
Score = 75.1 bits (183), Expect = 2e-11, Method: Composition-based stats.
Identities = 38/148 (26%), Positives = 59/148 (40%), Gaps = 26/148 (18%)
Query 1032 PMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKK 1091
+VNAAN G GV A+ + K D + VG + L+ + +
Sbjct 1347 EEAVVNAANAKGTVGVGVCRAVAR-------KWPDSF--KGAATPVGTAKLVQANGM--N 1395
Query 1092 CLHVVGPNLNAGEDIQ---LLKAAYE------NFNSQDILLAPLLSAGIFGA------KP 1136
+H VGPN + + + L AAY N ++ + PLLS G+F +
Sbjct 1396 VIHAVGPNFSTVTEAEGDRELAAAYRAVAGIINASNIKSVAIPLLSTGVFSGGKDRVMQS 1455
Query 1137 LQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L L + T V I DKA +++
Sbjct 1456 LNHLFTAMDTTDADVVIYCRDKAWEKKI 1483
>sp|Q8QZ73|POLN_MAYAB Polyprotein P1234 OS=Mayaro virus (strain
Brazil) OX=374990 PE=1 SV=3
Length=2437
Score = 74.0 bits (180), Expect = 4e-11, Method: Composition-based stats.
Identities = 40/168 (24%), Positives = 58/168 (35%), Gaps = 30/168 (18%)
Query 1012 LTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKL 1071
A+K DI +VNAAN + G GV A+ + A
Sbjct 1334 CAPAYAVKRADIATAI----EDAVVNAANHRGQVGDGVCRAVARKWPQAF---------R 1380
Query 1072 NGPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYE---------NFNSQDIL 1122
N VG + + +H VGPN N + + + N S +
Sbjct 1381 NAATPVGTAKTVKCDE--TYIIHAVGPNFNNTSEAEGDRDLAAAYRAVAAEINRLSISSV 1438
Query 1123 LAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
PLLS GIF A + L L + T +V I DK +++
Sbjct 1439 AIPLLSTGIFSAGKDRVHQSLSHLLAAMDTTEARVTIYCRDKTWEQKI 1486
>sp|Q8QL53|POLN_SLDV Polyprotein P1234 OS=Sleeping disease virus
OX=78540 PE=3 SV=1
Length=2593
Score = 73.6 bits (179), Expect = 5e-11, Method: Composition-based stats.
Identities = 42/164 (26%), Positives = 61/164 (37%), Gaps = 26/164 (16%)
Query 1025 KEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLS 1084
K +A V+VNAAN + + G GV GAL A A NG + G + L+
Sbjct 1429 KNIITAEEEVLVNAANSNGRPGDGVCGALYGAFGDAF---------PNGAIGAGNAVLVR 1479
Query 1085 GHNLAKKCLHVVGPNLNAGED---IQLLKAAYEN------FNSQDILLAPLLSAGIFG-- 1133
G L +H G + ++ + L+AAY N PLLS IF
Sbjct 1480 G--LEATIIHAAGADFREVDEETGARQLRAAYRAAATLVTANGITSAAIPLLSTHIFSNG 1537
Query 1134 -AKPLQSLQVCV---QTVRTQVYIAVNDKALYEQVVMDYLDNLK 1173
+ QS V T V I + ++ D+ +
Sbjct 1538 RNRLEQSFGALVEAFDTTECDVTIYCLANNMAARIQQLIDDHAR 1581
>sp|Q9YBE9|Y1648_AERPE Uncharacterized protein APE_1648.1 OS=Aeropyrum
pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 /
NBRC 100138 / K1) OX=272557 GN=APE_1648.1 PE=4 SV=2
Length=189
Score = 67.0 bits (162), Expect = 1e-10, Method: Composition-based stats.
Identities = 32/126 (25%), Positives = 54/126 (43%), Gaps = 16/126 (13%)
Query 1016 VAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPL 1075
+A+ D+ K +VN AN + GGG AGAL +A +++E+ P+
Sbjct 11 LAVSMGDLTK----VRAEAVVNPANSLMIMGGGAAGALKRAGGSVIEEEAM----RKAPV 62
Query 1076 TVGGSCLLSGHNL-AKKCLHV-----VGPNLNAGEDIQLLKAAYENFNSQDI--LLAPLL 1127
VG + + SG +L A+ +H G + + AA + I + P +
Sbjct 63 PVGEAVITSGGSLPARFVIHAPTMEEPGMRIPLVNAFKASYAALRLASEAGIESVAMPAM 122
Query 1128 SAGIFG 1133
AG+ G
Sbjct 123 GAGVGG 128
>sp|Q5XGM5|GDAP2_XENLA Ganglioside-induced differentiation-associated
protein 2 OS=Xenopus laevis OX=8355 PE=2 SV=1
Length=496
Score = 70.9 bits (172), Expect = 1e-10, Method: Composition-based stats.
Identities = 46/243 (19%), Positives = 86/243 (35%), Gaps = 31/243 (13%)
Query 973 VEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANP 1032
V EE ED D + P P + + V + D+ N
Sbjct 22 VSNEEGEDVPDGGRKDVPDGGSHSPFPYRK--------DINEKVILWKGDVA----LLNC 69
Query 1033 MVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKK 1091
+VN +N L V+ ++ + + + +E KL G G + L G NL A+
Sbjct 70 TALVNTSNETLTDKNPVSDSIFRYSGPELLEE---MQKLKG-CRTGEAKLTKGFNLAARY 125
Query 1092 CLHVVGPNLNAG---EDIQLLKAAYENFNSQ------DILLAPLLSAGIFGAKPLQSLQV 1142
+H VGP L + Y N + +++ + +
Sbjct 126 IIHTVGPKYKTKYRTAAESSLYSCYRNVLQLAKEQGMASVGFCVITTQKRCYPLDDATHI 185
Query 1143 CVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPV 1202
++TVR ++ V+ +AL E+VV + + + + E++S++ P
Sbjct 186 ALRTVRR--FLEVHGQAL-EKVVFAVTEEEEGTYR--RLLPLYFPRSLEEEQRSILLLPQ 240
Query 1203 DVK 1205
D+
Sbjct 241 DIG 243
>sp|Q86500|POLN_RUBVM Non-structural polyprotein p200 OS=Rubella
virus (strain M33) OX=11043 PE=1 SV=2
Length=2116
Score = 71.3 bits (173), Expect = 3e-10, Method: Composition-based stats.
Identities = 50/233 (21%), Positives = 83/233 (36%), Gaps = 21/233 (9%)
Query 970 TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS 1029
T + L+ E S + P+ + + Y + V ++ DI+
Sbjct 775 TAEPADRARHAELEVVYEPSGPPTSTKADPDSDIVE--SYARAAGPVHLRVRDIMDPPPG 832
Query 1030 ANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLA 1089
V+VNAAN L G GV GA+ A+ + P +G + GH
Sbjct 833 CK--VVVNAANEGLLAGSGVCGAIFANATAALAADCRRLA----PCPIGEAVATPGHGCG 886
Query 1090 -KKCLHVVGPN-----LNAGEDIQLLKAAYENFNSQDILLA------PLLSAGIFGAKPL 1137
+H V P E LL+ AY + + PLL AG++G
Sbjct 887 YTHIIHAVAPRRPRDPAALEEGEALLERAYRSIVALAAARRWARVACPLLGAGVYGWSAA 946
Query 1138 QSLQVCVQTVRTQVYIAVNDKAL-YEQVVMDYLDNLKPRVEAPKQEEPPNTED 1189
+SL+ + R + V+ ++ + + L A ++ PP TE
Sbjct 947 ESLRAALAATRAEPAERVSLHICHPDRATLTHASVLVGAGLAARRVSPPPTEP 999
>sp|Q5Y389|POLN_GETV Polyprotein P1234 OS=Getah virus OX=59300
PE=1 SV=3
Length=2467
Score = 71.3 bits (173), Expect = 3e-10, Method: Composition-based stats.
Identities = 33/149 (22%), Positives = 52/149 (35%), Gaps = 26/149 (17%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAK 1090
+ +VNAAN GV A+ K + VG + ++ +
Sbjct 1347 SEEAVVNAANAKGTVSDGVCRAVAKKWPSSF---------KGAATPVGTAKMIRADGM-- 1395
Query 1091 KCLHVVGPNLNAGEDIQ---LLKAAYEN------FNSQDILLAPLLSAGIFGA------K 1135
+H VGPN + + + L AAY N+ + PLLS G F +
Sbjct 1396 TVIHAVGPNFSTVTEAEGDRELAAAYRAVASIISTNNIKSVAVPLLSTGTFSGGKDRVMQ 1455
Query 1136 PLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L L + V I DK +++
Sbjct 1456 SLNHLFTALDATDADVVIYCRDKNWEKKI 1484
>sp|Q9JGL0|POLN_SAGV Polyprotein P1234 OS=Sagiyama virus OX=59303
PE=3 SV=3
Length=2467
Score = 71.3 bits (173), Expect = 3e-10, Method: Composition-based stats.
Identities = 33/149 (22%), Positives = 51/149 (34%), Gaps = 26/149 (17%)
Query 1031 NPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAK 1090
+VNAAN GV A+ K + VG + ++ +
Sbjct 1347 GEEAVVNAANAKGTVSDGVCRAVAKKWPSSF---------KGAATPVGTAKMIRADGM-- 1395
Query 1091 KCLHVVGPNLNAGEDIQ---LLKAAYEN------FNSQDILLAPLLSAGIFGA------K 1135
+H VGPN + + + L AAY N+ + PLLS G F +
Sbjct 1396 TVIHAVGPNFSTVTEAEGDRELAAAYRAVASIISTNNIKSVAVPLLSTGTFSGGKDRVMQ 1455
Query 1136 PLQSLQVCVQTVRTQVYIAVNDKALYEQV 1164
L L + V I DK +++
Sbjct 1456 SLNHLFTALDATDADVVIYCRDKNWEKKI 1484
>sp|Q8JJX1|POLN_SPDV Polyprotein P1234 OS=Salmon pancreas disease
virus OX=84589 PE=3 SV=1
Length=2601
Score = 70.9 bits (172), Expect = 3e-10, Method: Composition-based stats.
Identities = 40/142 (28%), Positives = 54/142 (38%), Gaps = 26/142 (18%)
Query 1029 SANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL 1088
+A V+VNAAN + + G GV GAL A A NG + G + L+ G L
Sbjct 1434 TAEEEVLVNAANSNGRPGDGVCGALYGAFGDAF---------PNGAIGAGNAVLVRG--L 1482
Query 1089 AKKCLHVVGPNLNAGED---IQLLKAAYEN------FNSQDILLAPLLSAGIFG---AKP 1136
+H G + ++ + L+AAY N PLLS IF +
Sbjct 1483 EATIIHAAGADFREVDEETGARQLRAAYRAAATLVTANGITSAAIPLLSTHIFSNGRNRL 1542
Query 1137 LQSLQVCV---QTVRTQVYIAV 1155
QS V T V I
Sbjct 1543 EQSFSALVEAFDTTECDVTIYC 1564
>sp|Q2KIX2|GDAP2_BOVIN Ganglioside-induced differentiation-associated
protein 2 OS=Bos taurus OX=9913 GN=GDAP2 PE=2 SV=1
Length=497
Score = 69.0 bits (167), Expect = 6e-10, Method: Composition-based stats.
Identities = 48/236 (20%), Positives = 87/236 (37%), Gaps = 24/236 (10%)
Query 980 DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAA 1039
+ +D SEI E E + F + V + D+ N IVN +
Sbjct 21 NSCEDQLNASEIAAE-TYQEETIRSPFLYNKDINGKVVLWKGDVA----LLNCTAIVNTS 75
Query 1040 NIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGP 1098
N L V+ ++ +++ D KL G G + L G NL A+ +H VGP
Sbjct 76 NESLTDKNPVSESIFMLAGPDLKE---DLQKLRG-CRTGEAKLTKGFNLAARFIIHTVGP 131
Query 1099 NLNAG---EDIQLLKAAYENFN------SQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+ L + Y N S + ++++ G + + ++TVR
Sbjct 132 KYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRR 191
Query 1150 QVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVK 1205
++ ++ + L E+VV + + + K K E +S+ P D+
Sbjct 192 --FLEIHGETL-EKVVFAVSELEEATYQ--KLLPLYFPRSLKEESRSLPCLPADIG 242
>sp|Q9NXN4|GDAP2_HUMAN Ganglioside-induced differentiation-associated
protein 2 OS=Homo sapiens OX=9606 GN=GDAP2 PE=1 SV=1
Length=497
Score = 68.6 bits (166), Expect = 8e-10, Method: Composition-based stats.
Identities = 50/238 (21%), Positives = 82/238 (34%), Gaps = 28/238 (12%)
Query 980 DWLDDTTEQSEIEPE--PEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVN 1037
D D S+ E E T P F + V + D+ N IVN
Sbjct 21 DSCQDELNSSDTTAEIFQEDTVRSP---FLYNKDVNGKVVLWKGDVA----LLNCTAIVN 73
Query 1038 AANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVV 1096
+N L V+ ++ +++ D KL G G + L G NL A+ +H V
Sbjct 74 TSNESLTDKNPVSESIFMLAGPDLKE---DLQKLKG-CRTGEAKLTKGFNLAARFIIHTV 129
Query 1097 GPNLNAG---EDIQLLKAAYENFN------SQDILLAPLLSAGIFGAKPLQSLQVCVQTV 1147
GP + L + Y N S + ++++ G + + ++TV
Sbjct 130 GPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTV 189
Query 1148 RTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVK 1205
R + I E+VV D + + K K E +S+ P D+
Sbjct 190 RRFLEIH---GETIEKVVFAVSDLEEGTYQ--KLLPLYFPRSLKEENRSLPYLPADIG 242
>sp|Q66HX8|GDAP2_DANRE Ganglioside-induced differentiation-associated
protein 2 OS=Danio rerio OX=7955 GN=gdap2 PE=2 SV=1
Length=504
Score = 67.8 bits (164), Expect = 2e-09, Method: Composition-based stats.
Identities = 51/262 (19%), Positives = 89/262 (34%), Gaps = 27/262 (10%)
Query 979 EDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNA 1038
+D LD E E E E +N ++ K V + N IVN
Sbjct 26 QDELDGENHYEEEEEEEEDNLTNQLNSVNSPFTFRQDINNKIVLFNGDVALLNCTAIVNT 85
Query 1039 ANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVG 1097
+N L ++ ++++ ++ E +KL G G + + G +L A+ +H VG
Sbjct 86 SNETLTDKNPISDSIHRHAGPELRDE---LLKLKG-CRTGEAKMTEGFDLAARFIIHTVG 141
Query 1098 PNLNAG---EDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQTVR 1148
P A L + Y N ++ + ++S + + ++TVR
Sbjct 142 PKYKAKYRTAAESSLYSCYRNVLQLAKEHAMVSVGFCVISTVKRAYPVEDATHIALRTVR 201
Query 1149 TQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVK--- 1205
N E +V D +P K + E S+ P D+
Sbjct 202 ---RFLENHGENIETLVFAVSDVEEPVYR--KLLPLYYPRSKQEERISLPLLPADIGNSE 256
Query 1206 -----PKIKACIDEVTTTLEET 1222
P+ + I E LE+
Sbjct 257 GEPVVPERQIRIAEKPVNLEDD 278
>sp|Q66H63|GDAP2_RAT Ganglioside-induced differentiation-associated-protein
2 OS=Rattus norvegicus OX=10116 GN=Gdap2 PE=2
SV=1
Length=497
Score = 66.7 bits (161), Expect = 3e-09, Method: Composition-based stats.
Identities = 45/236 (19%), Positives = 81/236 (34%), Gaps = 24/236 (10%)
Query 980 DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAA 1039
D +D S+ + + F + V + D+ N IVN +
Sbjct 21 DSYEDEVNSSD-STAEAFQEDSNRSPFLYNRDINGKVVLWKGDVA----LLNCTAIVNTS 75
Query 1040 NIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGP 1098
N L V+ ++ +++ D KL G G + L G NL A+ +H VGP
Sbjct 76 NESLTDKNPVSESIFMLAGPDLKE---DLQKLKG-CRTGEAKLTKGFNLAARFIIHTVGP 131
Query 1099 NLNAG---EDIQLLKAAYENFN------SQDILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
+ L + Y N S + ++++ G + + ++TVR
Sbjct 132 KYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRR 191
Query 1150 QVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVK 1205
+ I E+VV + + + K K E +S+ P D+
Sbjct 192 FLEIH---GETIEKVVFAISELEEATYQ--KLLPLYFPRSLKEESQSLPSLPADIG 242
>sp|Q9DBL2|GDAP2_MOUSE Ganglioside-induced differentiation-associated
protein 2 OS=Mus musculus OX=10090 GN=Gdap2 PE=1 SV=1
Length=498
Score = 66.7 bits (161), Expect = 4e-09, Method: Composition-based stats.
Identities = 49/242 (20%), Positives = 85/242 (35%), Gaps = 31/242 (13%)
Query 974 EEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPM 1033
E+E D D T E + + P F + V + D+ N
Sbjct 22 SYEDEVDCADSTAEAFQEDASRSP--------FVYSRDVNGKVVLWKGDVA----LLNCT 69
Query 1034 VIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKC 1092
IVN +N L V+ ++ +++ D KL G G + L G NL A+
Sbjct 70 AIVNTSNESLTDKNPVSESIFMLAGPDLKE---DLQKLKG-CRTGEAKLTKGFNLAARFI 125
Query 1093 LHVVGPNLNAG---EDIQLLKAAYENFN------SQDILLAPLLSAGIFGAKPLQSLQVC 1143
+H VGP + L + Y N S + ++++ G + +
Sbjct 126 IHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIA 185
Query 1144 VQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVD 1203
++TVR + I + E+VV + + + K K E +S+ P D
Sbjct 186 LRTVRRFLEIHGEN---IEKVVFAVSELEEATYQ--KLLPLYFPRSLKEEIRSLPYLPAD 240
Query 1204 VK 1205
+
Sbjct 241 IG 242
>sp|Q460N3|PAR15_HUMAN Protein mono-ADP-ribosyltransferase PARP15
OS=Homo sapiens OX=9606 GN=PARP15 PE=1 SV=2
Length=678
Score = 66.7 bits (161), Expect = 4e-09, Method: Composition-based stats.
Identities = 38/178 (21%), Positives = 65/178 (37%), Gaps = 15/178 (8%)
Query 1015 NVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGG-VAGALNKATNGAMQKESDDYIKLNG 1073
N+ + D++ VIVN+ ++L+ GGG ++ A + +QKE DD +
Sbjct 90 NLKLISGDVL----YIWADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQKELDD-RRRET 144
Query 1074 PLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQ------LLKAAYENFN--SQDILLA 1124
VG + SG NL K LH V P N G + ++K S +
Sbjct 145 EEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSWQIMANIIKKCLTTVEVLSFSSITF 204
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQE 1182
P++ G ++ + V + ++V N +A E
Sbjct 205 PMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSPLQEVHFLVYTNDDEGCQAFLDE 262
Score = 44.3 bits (103), Expect = 0.029, Method: Composition-based stats.
Identities = 25/151 (17%), Positives = 43/151 (28%), Gaps = 11/151 (7%)
Query 998 TPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKAT 1057
T +P + DI E VIVN+ GV+ A+ +
Sbjct 288 TVSKPCFTAYEMKIGAITFQVATGDIATE----QVDVIVNSTARTFNRKSGVSRAILEGA 343
Query 1058 NGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENF 1116
A++ E + G L K +HV G +L+ +
Sbjct 344 GQAVESECAVLAAQ----PHRDFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQ-- 397
Query 1117 NSQDILLAPLLSAGIFGAKPLQSLQVCVQTV 1147
+ P + G G P+ + +
Sbjct 398 RKYTSVSLPAIGTGNAGKNPITVADNIIDAI 428
>sp|Q4R678|GDAP2_MACFA Ganglioside-induced differentiation-associated
protein 2 OS=Macaca fascicularis OX=9541 GN=GDAP2 PE=2
SV=1
Length=461
Score = 65.1 bits (157), Expect = 9e-09, Method: Composition-based stats.
Identities = 41/190 (22%), Positives = 71/190 (37%), Gaps = 19/190 (10%)
Query 1026 EAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSG 1085
E S++ IVN +N L V+ ++ +++ D KL G G + L G
Sbjct 26 ELNSSDTTAIVNTSNESLTDKNPVSESIFMLAGPDLKE---DLQKLKG-CRTGEAKLTKG 81
Query 1086 HNL-AKKCLHVVGPNLNAG---EDIQLLKAAYENFN------SQDILLAPLLSAGIFGAK 1135
NL A+ +H VGP + L + Y N S + ++++ G
Sbjct 82 FNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYP 141
Query 1136 PLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEK 1195
+ + ++TVR + I E+VV D + + K K E +
Sbjct 142 LEDATHIALRTVRRFLEIH---GETIEKVVFAVSDLEEATYQ--KLLPLYFPRSLKEENR 196
Query 1196 SVVQKPVDVK 1205
S+ P D+
Sbjct 197 SLPYLPADIG 206
>sp|Q5CZL1|GDAP2_XENTR Ganglioside-induced differentiation-associated
protein 2 OS=Xenopus tropicalis OX=8364 PE=2 SV=1
Length=496
Score = 64.3 bits (155), Expect = 2e-08, Method: Composition-based stats.
Identities = 43/236 (18%), Positives = 83/236 (35%), Gaps = 23/236 (10%)
Query 980 DWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAA 1039
D D E + + F + V + D+ + +A +VN +
Sbjct 21 DVRDGEGEDVPDGGRKDAPHGGLHSPFPYRNDINKKVILWRGDVALLSCTA----LVNTS 76
Query 1040 NIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGP 1098
N L V+ ++ + + + S++ KL G G + L G NL A+ +H VGP
Sbjct 77 NETLTDKNPVSDSIFRYSGPEL---SEEMQKLKG-CRTGEAKLTKGFNLAARYIIHTVGP 132
Query 1099 NLNAG---EDIQLLKAAYENFNSQ------DILLAPLLSAGIFGAKPLQSLQVCVQTVRT 1149
L + Y N + +++ P S + ++TVR
Sbjct 133 KYKTKYRTAAESSLYSCYRNVLQLAKEQGMASVGFCVIATQKRCYPPEDSTHIALRTVRR 192
Query 1150 QVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVK 1205
++ + AL E+VV + + + + E++S+ P D+
Sbjct 193 --FLEAHGAAL-EKVVFAVTEQEEGTYR--RLLPLYFPRSLEEEQRSIPFLPQDIG 243
>sp|Q9P0M6|H2AW_HUMAN Core histone macro-H2A.2 OS=Homo sapiens
OX=9606 GN=MACROH2A2 PE=1 SV=3
Length=372
Score = 62.8 bits (151), Expect = 4e-08, Method: Composition-based stats.
Identities = 27/124 (22%), Positives = 44/124 (35%), Gaps = 11/124 (9%)
Query 1035 IVNA--ANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLL-SGHNLAKK 1091
IV+ A I LK G AL KA + + K GPL V + + S AK
Sbjct 215 IVHPTTAEIDLKEDIG--KALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKF 272
Query 1092 CLHVVGPNLNAGEDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQ 1145
+H P + + + L+ +N + P +G + QV ++
Sbjct 273 VIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLK 332
Query 1146 TVRT 1149
+
Sbjct 333 AISA 336
>sp|Q8CCK0|H2AW_MOUSE Core histone macro-H2A.2 OS=Mus musculus
OX=10090 GN=Macroh2a2 PE=1 SV=3
Length=372
Score = 60.9 bits (146), Expect = 1e-07, Method: Composition-based stats.
Identities = 27/124 (22%), Positives = 44/124 (35%), Gaps = 11/124 (9%)
Query 1035 IVNA--ANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLL-SGHNLAKK 1091
IV+ A I LK G AL KA + + K GPL V + + S AK
Sbjct 215 IVHPTTAEIDLKEEIG--KALEKAGGKEFLETVKELRKSQGPLEVAEAAVSQSSGLAAKF 272
Query 1092 CLHVVGPNLNAGEDIQLLKAAYENF------NSQDILLAPLLSAGIFGAKPLQSLQVCVQ 1145
+H P + + + L+ +N + P +G + QV ++
Sbjct 273 VIHCHIPQWGSDKCEEQLEETIKNCLSAAEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLK 332
Query 1146 TVRT 1149
+
Sbjct 333 AISA 336
>sp|Q9YLR1|POLN_HEVUS Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 3 (isolate Human/United States/US2) OX=509615
GN=ORF1 PE=3 SV=1
Length=1708
Score = 60.5 bits (145), Expect = 5e-07, Method: Composition-based stats.
Identities = 37/213 (17%), Positives = 68/213 (32%), Gaps = 26/213 (12%)
Query 953 TEDDYQGLPLEFGASAETVRVEEEEEED------WLDDTTEQSEIEPEPEPTPEEPVNQF 1006
D + P + + V E L + P
Sbjct 737 VSDIWVLPPPSEESHVDAASVPSVPEPAGLTSPIVLTPPPPPPPVRKPATSPPPRTRRLL 796
Query 1007 TGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESD 1066
Y D + + + + +VNA+N + GGG+ A + A S
Sbjct 797 YTY---PDGAKVYAGSLXES----DCDWLVNASNPGHRPGGGLCHAFYQRFPEAF--YST 847
Query 1067 DYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLNAGEDIQLLKAAYENFNS-QDILLA 1124
++I G L+ + L + +H V P+ ++ + L+AAY S +
Sbjct 848 EFIMREG---------LAAYTLTPRPIIHAVAPDYRVEQNPKRLEAAYRETCSRRGTAAY 898
Query 1125 PLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVND 1157
PLL +GI+ S + R + + +
Sbjct 899 PLLGSGIYQVPVSLSFDAWERNHRPGDELYLTE 931
>sp|Q7JUR6|GDAP2_DROME Protein GDAP2 homolog OS=Drosophila melanogaster
OX=7227 GN=Gdap2 PE=2 SV=1
Length=540
Score = 57.4 bits (137), Expect = 3e-06, Method: Composition-based stats.
Identities = 35/220 (16%), Positives = 69/220 (31%), Gaps = 24/220 (11%)
Query 999 PEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATN 1058
P + F + + I D+ + I N ++ L ++ +
Sbjct 52 PRHNRSPFPLCKDVNNRFVIWDGDMT----TLEVDAITNTSDETLTESNSISERIFAVAG 107
Query 1059 GAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLN---AGEDIQLLKAAYE 1114
+++E +K G + G+NL AK LH V P L Y
Sbjct 108 NQLREELSTTVK---ECRTGDVRITRGYNLPAKYVLHTVAPAYREKFKTAAENTLHCCYR 164
Query 1115 NFNSQ------DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDY 1168
N + + +SA + + ++T+R + DK + V++
Sbjct 165 NVLCKAKELNLHTIALCNISAHQKSFPADVAAHIALRTIRRYL-----DKCTLQVVILCV 219
Query 1169 LDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
+ + E D E ++ Q P D+ +
Sbjct 220 GSSERGTYEVL--APLYFPRDQLEERSALWQLPKDIGGEF 257
>sp|A0A0D2UG83|H2AY_CAPO3 Histone macroH2A1.1 OS=Capsaspora owczarzaki
(strain ATCC 30864) OX=595528 GN=CAOG_004778 PE=1 SV=1
Length=368
Score = 56.6 bits (135), Expect = 3e-06, Method: Composition-based stats.
Identities = 41/188 (22%), Positives = 67/188 (36%), Gaps = 10/188 (5%)
Query 999 PEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATN 1058
P++PV FT K T ++ + + +V+ N + G V GA+ A
Sbjct 176 PKKPVRGFTILSKKTLHLGQTLYVVNGDLTEVRCDAVVHPTNGTMSFAGQVGGAIRAAAG 235
Query 1059 GAMQKESDDYIKLNGPLTVGGSCLLSGHNLA-KKCLHVVGPNL-NAGEDIQLLKAAYEN- 1115
+ E + Y+ + L V + + SGHNL K +HV PN NA L N
Sbjct 236 AGVDAEVNSYMSEHSQLQVTKAAITSGHNLPSKWIVHVHSPNYSNAATATDALTQTIRNA 295
Query 1116 -----FNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDYLD 1170
S + P + +G + Q +Q + Y + ++V D
Sbjct 296 LTLADTKSIKTIAFPSIGSGNNHFPKHIAAQTILQAISA--YFMSIMSSSIKEVYFVLFD 353
Query 1171 NLKPRVEA 1178
V
Sbjct 354 QESINVYN 361
>sp|Q81862|POLN_HEVCH Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 1 (isolate Human/China/HeBei/1987) OX=652674
GN=ORF1 PE=1 SV=1
Length=1693
Score = 57.4 bits (137), Expect = 4e-06, Method: Composition-based stats.
Identities = 24/109 (22%), Positives = 41/109 (38%), Gaps = 11/109 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNA+N+ + GGG+ A + + S G + + +H
Sbjct 803 LVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRD-------GAAAYT---LTPRPIIH 852
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQV 1142
V P+ + ++L+AAY S+ PLL GI+ S
Sbjct 853 AVAPDYRLEHNPKMLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDA 901
>sp|Q008X5|R1A_WBV24 Replicase polyprotein 1a OS=White bream virus
(isolate Blicca bjoerkna L./Germany/DF24/00) OX=766180
GN=1a PE=1 SV=1
Length=4555
Score = 57.0 bits (136), Expect = 5e-06, Method: Composition-based stats.
Identities = 119/804 (15%), Positives = 241/804 (30%), Gaps = 120/804 (15%)
Query 2998 VDAMNLIANIFTPLVQPVGALDVSASVVAGGII---AILVTCAAYYFMKFRRVFGEYNHV 3054
+ L + + V+ L AS ++ ++++ +Y + +F Y +
Sbjct 3219 SNTKKLCVQVGSNAVRCASVLPTGASSNVAALLMASVVVISMVLFYLYLLQ-IFKFYTNS 3277
Query 3055 VAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVP 3114
V + ++ L++ + + ++ + Y Y ++ + ++
Sbjct 3278 VIMSFVIQLLTLLATTVSTPLAVTVQLFVITYGYTN--------WILLTLSLLNLTVLLS 3329
Query 3115 FWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF---STFEEAALCTFLLNKEMYLKLR 3171
+ +V L + F + + V G T +FE+ A TF L ++L
Sbjct 3330 TPVGITFVVIYGLYKAYTLFTSSGQGCVYNEGGTIRFSGSFEQVANSTFPLTNASCVQLL 3389
Query 3172 SETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQ 3231
S+ + Q N Y + ++ + R A L + L+ S +LY+
Sbjct 3390 SDLGITYQQLNVYASSRDR-----------NVRRLAQALLHRQLDSASEC---ILYE--G 3433
Query 3232 TSITSAVLQSGFRKMAFPSGKVEGCMVQVT-CGTTTLNGLWLD---------DTVYCPRH 3281
S + Q+ R + V + + NG+ L + + C H
Sbjct 3434 CSGNTITRQALQRIRQAVTVVVTPASQNLCKITSNQANGIGLSCTGTFFTSTEIITCA-H 3492
Query 3282 VICTAEDML---NPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKT 3338
I T++ Y+ + +N ++ V L V + + + +
Sbjct 3493 GIGTSDITAVHKGITYDCKVKSINNDIAILITTTVNLSVQNIKLDSSFSQKSDNYQRNFV 3552
Query 3339 PKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVS 3398
FV Q ++ + H G GS + ++ + +
Sbjct 3553 QFVSFVDQQNSDAVTINN----------TVMLPSGHFFAIGTEAGESGSP-YTLNGNII- 3600
Query 3399 FCYMHHMELPTGVHAGTDLEGKFY------GPFVDRQTAQAAGTDTTITLNVLAWLYAAV 3452
G+H G D G + G F T T + + A + A+
Sbjct 3601 -----------GIHYGIDNAGSWMLASRPDGSFYVPATQHGNSAKVTFSTDAFAQQFPAI 3649
Query 3453 INGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELL 3512
+ T+ N +A N D D V + LK L
Sbjct 3650 V--------TNKTSDQLVNEIAATNN-TAFELDTTD------------VSHLSNLLKHLK 3688
Query 3513 QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILV 3572
N + L D V +Q S VT V + L S +I
Sbjct 3689 NNNETPK------SLSDYLPVAPVTQQTS-VTVGQTLTSPVNNMQTALYTLMLVSEVITY 3741
Query 3573 QSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYM 3632
T N+ L + + +A K + L ++ T + +
Sbjct 3742 ILT---------PNSDLSVLISMFVTSAFLKFGAS-KLFYNTEMLRNTITTFVVYRYTTL 3791
Query 3633 PASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVI 3692
+ V L+ + + + L+L+T R VY + + + + +I
Sbjct 3792 LIALVFSQYYLHILSYALKLNTLVLTVIALTFLVTPLVLLTIRRVYYYSQNYLISCVFII 3851
Query 3693 TLV--YKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
+ + D + +IS + + + I F + P
Sbjct 3852 SCFASHTYTLYILTDTTVDFQTFIIS------EPIFSTLLCNLFIGFTLISVVPNPLYVC 3905
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLF 3774
I+L LG+ C+ +
Sbjct 3906 VVFMYILLDCEALGFIVTCFMASY 3929
Score = 49.7 bits (117), Expect = 9e-04, Method: Composition-based stats.
Identities = 42/200 (21%), Positives = 61/200 (31%), Gaps = 37/200 (19%)
Query 1004 NQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAM-- 1061
N F + V +I + IVNAAN L +G GV GA+ A + +
Sbjct 1642 NPFAS----NEGVTFAVHNI-GAITTTEGEFIVNAANKQLNNGTGVTGAIFAAHDKELKL 1696
Query 1062 ---------QKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPN------------- 1099
SD + + A LH P
Sbjct 1697 TQAIKALPTYGASDKLESHQHVVQT--IIKNNNSTHAINILHAAAPIKVKCTSKNPEVLL 1754
Query 1100 LNAGEDIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYI 1153
+ LK Y+ N + PL AG +G KPL SL+ + +R +
Sbjct 1755 AHNETAQSELKETYKAIVDYAQLNKLTHIYLPLFGAGAYGHKPLDSLEAFLDAMRNRSPQ 1814
Query 1154 AVNDKALYEQVVMDYLDNLK 1173
+ L + LDN
Sbjct 1815 STTQYTLLLSDPVKPLDNPS 1834
Score = 40.9 bits (94), Expect = 0.41, Method: Composition-based stats.
Identities = 52/341 (15%), Positives = 91/341 (27%), Gaps = 59/341 (17%)
Query 2110 VPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKST--NSRI 2167
+S LAY+ + Y+ T T+ T + I
Sbjct 2551 CTFSVFLAYIALLYSFSGHGIFTVVAYFTMLFARYYITSFINFCTSQLTATQVTQWFAAI 2610
Query 2168 RASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAF 2227
+A + + + + Y+ K+S + T+ M++ ++
Sbjct 2611 KAKYTGIYESSQDRVLTVNVTGTNVPYI--VKYSTILTVTMYVAFMAFVWTVSTYAAQYT 2668
Query 2228 G-----------VLLSNFGAPSYCNGVRELYLNSSNVTTMDFCE--GSFPCSI-CLSGLD 2273
V V Y +S + C S C +
Sbjct 2669 AGERYDRPPYQTVFQKTLNVLGLTETVTYYYPYAS---LNEACAASTSILCRLGSPFNFH 2725
Query 2274 SLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFAS 2333
Y + T+Q SS + LF F L ++ +
Sbjct 2726 YPSDYTQVRTVQTDTSS----------------PFWLFIIFMPPSFLFIVLPWLILCTIT 2769
Query 2334 HFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRN 2393
+SI Q+ S ++ I F Y K H C TC+ +
Sbjct 2770 P----------TVSIAQLLVPSIILNATIVF--IYIRRKFTGHC---CGPHTCIKHADIS 2814
Query 2394 RATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDT 2434
R+ + T+ + C HNW C N D+
Sbjct 2815 RSLQFRPTSQIQHSLTFC-------GTLCAKHNWYCNNSDS 2848
Score = 40.9 bits (94), Expect = 0.47, Method: Composition-based stats.
Identities = 20/75 (27%), Positives = 27/75 (36%), Gaps = 11/75 (15%)
Query 4283 QAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGF-- 4340
AI+ P + ++ G S C C DH C G +VQIP ++
Sbjct 4467 IAISQVPVQTIGYLTYAGISVCRQCATKQDH-----TCQYAGYFVQIPREHVSNIFNLTD 4521
Query 4341 ---TLRNT-VCTVCG 4351
L N CT C
Sbjct 4522 TPPCLHNKFTCTTCQ 4536
>sp|Q008X6|R1AB_WBV24 Replicase polyprotein 1ab OS=White bream
virus (isolate Blicca bjoerkna L./Germany/DF24/00) OX=766180
GN=rep PE=1 SV=1
Length=6872
Score = 57.0 bits (136), Expect = 5e-06, Method: Composition-based stats.
Identities = 119/804 (15%), Positives = 241/804 (30%), Gaps = 120/804 (15%)
Query 2998 VDAMNLIANIFTPLVQPVGALDVSASVVAGGII---AILVTCAAYYFMKFRRVFGEYNHV 3054
+ L + + V+ L AS ++ ++++ +Y + +F Y +
Sbjct 3219 SNTKKLCVQVGSNAVRCASVLPTGASSNVAALLMASVVVISMVLFYLYLLQ-IFKFYTNS 3277
Query 3055 VAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVP 3114
V + ++ L++ + + ++ + Y Y ++ + ++
Sbjct 3278 VIMSFVIQLLTLLATTVSTPLAVTVQLFVITYGYTN--------WILLTLSLLNLTVLLS 3329
Query 3115 FWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTF---STFEEAALCTFLLNKEMYLKLR 3171
+ +V L + F + + V G T +FE+ A TF L ++L
Sbjct 3330 TPVGITFVVIYGLYKAYTLFTSSGQGCVYNEGGTIRFSGSFEQVANSTFPLTNASCVQLL 3389
Query 3172 SETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQ 3231
S+ + Q N Y + ++ + R A L + L+ S +LY+
Sbjct 3390 SDLGITYQQLNVYASSRDR-----------NVRRLAQALLHRQLDSASEC---ILYE--G 3433
Query 3232 TSITSAVLQSGFRKMAFPSGKVEGCMVQVT-CGTTTLNGLWLD---------DTVYCPRH 3281
S + Q+ R + V + + NG+ L + + C H
Sbjct 3434 CSGNTITRQALQRIRQAVTVVVTPASQNLCKITSNQANGIGLSCTGTFFTSTEIITCA-H 3492
Query 3282 VICTAEDML---NPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKT 3338
I T++ Y+ + +N ++ V L V + + + +
Sbjct 3493 GIGTSDITAVHKGITYDCKVKSINNDIAILITTTVNLSVQNIKLDSSFSQKSDNYQRNFV 3552
Query 3339 PKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVS 3398
FV Q ++ + H G GS + ++ + +
Sbjct 3553 QFVSFVDQQNSDAVTINN----------TVMLPSGHFFAIGTEAGESGSP-YTLNGNII- 3600
Query 3399 FCYMHHMELPTGVHAGTDLEGKFY------GPFVDRQTAQAAGTDTTITLNVLAWLYAAV 3452
G+H G D G + G F T T + + A + A+
Sbjct 3601 -----------GIHYGIDNAGSWMLASRPDGSFYVPATQHGNSAKVTFSTDAFAQQFPAI 3649
Query 3453 INGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCAALKELL 3512
+ T+ N +A N D D V + LK L
Sbjct 3650 V--------TNKTSDQLVNEIAATNN-TAFELDTTD------------VSHLSNLLKHLK 3688
Query 3513 QNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILV 3572
N + L D V +Q S VT V + L S +I
Sbjct 3689 NNNETPK------SLSDYLPVAPVTQQTS-VTVGQTLTSPVNNMQTALYTLMLVSEVITY 3741
Query 3573 QSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYM 3632
T N+ L + + +A K + L ++ T + +
Sbjct 3742 ILT---------PNSDLSVLISMFVTSAFLKFGAS-KLFYNTEMLRNTITTFVVYRYTTL 3791
Query 3633 PASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVI 3692
+ V L+ + + + L+L+T R VY + + + + +I
Sbjct 3792 LIALVFSQYYLHILSYALKLNTLVLTVIALTFLVTPLVLLTIRRVYYYSQNYLISCVFII 3851
Query 3693 TLV--YKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITG 3750
+ + D + +IS + + + I F + P
Sbjct 3852 SCFASHTYTLYILTDTTVDFQTFIIS------EPIFSTLLCNLFIGFTLISVVPNPLYVC 3905
Query 3751 NTLQCIMLVYCFLGYCCCCYFGLF 3774
I+L LG+ C+ +
Sbjct 3906 VVFMYILLDCEALGFIVTCFMASY 3929
Score = 49.7 bits (117), Expect = 0.001, Method: Composition-based stats.
Identities = 42/200 (21%), Positives = 61/200 (31%), Gaps = 37/200 (19%)
Query 1004 NQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAM-- 1061
N F + V +I + IVNAAN L +G GV GA+ A + +
Sbjct 1642 NPFAS----NEGVTFAVHNI-GAITTTEGEFIVNAANKQLNNGTGVTGAIFAAHDKELKL 1696
Query 1062 ---------QKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVVGPN------------- 1099
SD + + A LH P
Sbjct 1697 TQAIKALPTYGASDKLESHQHVVQT--IIKNNNSTHAINILHAAAPIKVKCTSKNPEVLL 1754
Query 1100 LNAGEDIQLLKAAYEN------FNSQDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYI 1153
+ LK Y+ N + PL AG +G KPL SL+ + +R +
Sbjct 1755 AHNETAQSELKETYKAIVDYAQLNKLTHIYLPLFGAGAYGHKPLDSLEAFLDAMRNRSPQ 1814
Query 1154 AVNDKALYEQVVMDYLDNLK 1173
+ L + LDN
Sbjct 1815 STTQYTLLLSDPVKPLDNPS 1834
Score = 40.9 bits (94), Expect = 0.42, Method: Composition-based stats.
Identities = 52/341 (15%), Positives = 91/341 (27%), Gaps = 59/341 (17%)
Query 2110 VPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFTKST--NSRI 2167
+S LAY+ + Y+ T T+ T + I
Sbjct 2551 CTFSVFLAYIALLYSFSGHGIFTVVAYFTMLFARYYITSFINFCTSQLTATQVTQWFAAI 2610
Query 2168 RASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAF 2227
+A + + + + Y+ K+S + T+ M++ ++
Sbjct 2611 KAKYTGIYESSQDRVLTVNVTGTNVPYI--VKYSTILTVTMYVAFMAFVWTVSTYAAQYT 2668
Query 2228 G-----------VLLSNFGAPSYCNGVRELYLNSSNVTTMDFCE--GSFPCSI-CLSGLD 2273
V V Y +S + C S C +
Sbjct 2669 AGERYDRPPYQTVFQKTLNVLGLTETVTYYYPYAS---LNEACAASTSILCRLGSPFNFH 2725
Query 2274 SLDSYPALETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFAS 2333
Y + T+Q SS + LF F L ++ +
Sbjct 2726 YPSDYTQVRTVQTDTSS----------------PFWLFIIFMPPSFLFIVLPWLILCTIT 2769
Query 2334 HFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRN 2393
+SI Q+ S ++ I F Y K H C TC+ +
Sbjct 2770 P----------TVSIAQLLVPSIILNATIVF--IYIRRKFTGHC---CGPHTCIKHADIS 2814
Query 2394 RATRVECTTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDT 2434
R+ + T+ + C HNW C N D+
Sbjct 2815 RSLQFRPTSQIQHSLTFC-------GTLCAKHNWYCNNSDS 2848
Score = 40.9 bits (94), Expect = 0.48, Method: Composition-based stats.
Identities = 20/75 (27%), Positives = 27/75 (36%), Gaps = 11/75 (15%)
Query 4283 QAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGF-- 4340
AI+ P + ++ G S C C DH C G +VQIP ++
Sbjct 4467 IAISQVPVQTIGYLTYAGISVCRQCATKQDH-----TCQYAGYFVQIPREHVSNIFNLTD 4521
Query 4341 ---TLRNT-VCTVCG 4351
L N CT C
Sbjct 4522 TPPCLHNKFTCTTCQ 4536
>sp|Q6J8G2|POLN_HEVMG Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 3 (isolate Swine/United States/swUS1)
OX=512345 GN=ORF1 PE=3 SV=1
Length=1708
Score = 56.6 bits (135), Expect = 6e-06, Method: Composition-based stats.
Identities = 28/125 (22%), Positives = 51/125 (41%), Gaps = 13/125 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCL 1093
+VNA+N + GGG+ A + A ++I G L+ + L + +
Sbjct 818 LVNASNPGHRPGGGLCHAFYQRFPEAFYP--TEFIMREG---------LAAYTLTPRPII 866
Query 1094 HVVGPNLNAGEDIQLLKAAYENFNS-QDILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVY 1152
H V P+ ++ + L+AAY S + PLL +GI+ S + R
Sbjct 867 HAVAPDYRVEQNPKRLEAAYRETCSRRGTAAYPLLGSGIYQVPVSLSFDAWERNHRPGDE 926
Query 1153 IAVND 1157
+ + +
Sbjct 927 LYLTE 931
>sp|P33424|POLN_HEVPA Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 1 (isolate Human/Pakistan/Sar-55) OX=33774
GN=ORF1 PE=1 SV=2
Length=1693
Score = 56.3 bits (134), Expect = 8e-06, Method: Composition-based stats.
Identities = 24/109 (22%), Positives = 40/109 (37%), Gaps = 11/109 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNA+N+ + GGG+ A + + S G + + +H
Sbjct 803 LVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRD-------GAAAYT---LTPRPIIH 852
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQV 1142
V P+ + + L+AAY S+ PLL GI+ S
Sbjct 853 AVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDA 901
>sp|P29324|POLN_HEVBU Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 1 (isolate Human/Burma) OX=31767 GN=ORF1
PE=1 SV=1
Length=1693
Score = 56.3 bits (134), Expect = 8e-06, Method: Composition-based stats.
Identities = 24/109 (22%), Positives = 40/109 (37%), Gaps = 11/109 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNA+N+ + GGG+ A + + S G + + +H
Sbjct 803 LVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRD-------GAAAYT---LTPRPIIH 852
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQV 1142
V P+ + + L+AAY S+ PLL GI+ S
Sbjct 853 AVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDA 901
>sp|Q292F9|GDAP2_DROPS Protein GDAP2 homolog OS=Drosophila pseudoobscura
pseudoobscura OX=46245 GN=GA15091 PE=3 SV=1
Length=542
Score = 55.5 bits (132), Expect = 9e-06, Method: Composition-based stats.
Identities = 35/220 (16%), Positives = 70/220 (32%), Gaps = 24/220 (11%)
Query 999 PEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATN 1058
P + F + + + I D+ + + I N ++ L ++ +
Sbjct 54 PRHNRSPFPLSKDVNNRLVIWDGDMT----TLDVDAITNTSDETLTESNIISERILAVAG 109
Query 1059 GAMQKESDDYIKLNGPLTVGGSCLLSGHNL-AKKCLHVVGPNLN---AGEDIQLLKAAYE 1114
+++E +K G + G+NL AK LH V P L Y
Sbjct 110 NQLREELSTNVK---ECRTGDVRITRGYNLPAKYVLHTVAPTYREKFKTAAENTLHCCYR 166
Query 1115 NFNSQ------DILLAPLLSAGIFGAKPLQSLQVCVQTVRTQVYIAVNDKALYEQVVMDY 1168
N + + +S + + ++T+R + DK + V++
Sbjct 167 NVLCKAKELNLHTIALCNISVHQKSFPADVAAHIALRTIRRYL-----DKCTLQVVILCV 221
Query 1169 LDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQKPVDVKPKI 1208
N + E D E ++ Q P D+ +
Sbjct 222 NSNERGTYEVL--APLYFPRDQLEERSALWQLPKDIGGEF 259
>sp|Q03495|POLN_HEVME Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 2 (isolate Human/Mexico) OX=31768 GN=ORF1
PE=3 SV=1
Length=1691
Score = 55.9 bits (133), Expect = 1e-05, Method: Composition-based stats.
Identities = 28/131 (21%), Positives = 46/131 (35%), Gaps = 15/131 (11%)
Query 1013 TDNVAIKCVDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLN 1072
D I I + + +VNA+N + GGG+ A Q+ D +
Sbjct 783 PDGAKIYVGSIFESECTW----LVNASNAGHRPGGGLCHAF-------FQRYPDSFDATK 831
Query 1073 GPLTVGGSCLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENF-NSQDILLAPLLSAGI 1131
+ G + + +H V P+ + + L+AAY + PLL AGI
Sbjct 832 FVMRDGLAAYT---LTPRPIIHAVAPDYRLEHNPKRLEAAYRETCARRGTAAYPLLGAGI 888
Query 1132 FGAKPLQSLQV 1142
+ S
Sbjct 889 YQVPVSLSFDA 899
>sp|Q9M041|BH140_ARATH Transcription factor bHLH140 OS=Arabidopsis
thaliana OX=3702 GN=BHLH140 PE=3 SV=1
Length=912
Score = 54.7 bits (130), Expect = 2e-05, Method: Composition-based stats.
Identities = 29/118 (25%), Positives = 44/118 (37%), Gaps = 14/118 (12%)
Query 1020 CVDIVK--EAQSANPMVIVNAANIHLK-HGGGVAGALNKATNGAMQKESDDYIKLNGPLT 1076
DI K + VI NA N LK GGGV A+ KA + E+ ++ N L
Sbjct 528 VGDITKLRSEGGLHCNVIANATNWRLKPGGGGVNAAIFKAAGPDL--ETATRVRAN-TLL 584
Query 1077 VGGSCLLSGHNLA--------KKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPL 1126
G + ++ + +HV+GPN+N L + + L
Sbjct 585 PGKAVVVPLPSTCPLHNAEGITHVIHVLGPNMNPNRPDNLNNDYTKGCKTLREAYTSL 642
>sp|Q9WC28|POLN_HEVHY Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 1 (isolate Human/India/Hyderabad) OX=512346
GN=ORF1 PE=1 SV=1
Length=1693
Score = 53.9 bits (128), Expect = 5e-05, Method: Composition-based stats.
Identities = 23/109 (21%), Positives = 38/109 (35%), Gaps = 11/109 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNA+N+ GGG+ A + + G + + +H
Sbjct 803 LVNASNVDHCPGGGLCHAFYQRYPASFDAACFVMRD-------GAAAYT---LTPRPIIH 852
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQV 1142
V P+ + + L+AAY S+ PLL GI+ S
Sbjct 853 RVAPDYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDA 901
>sp|Q04610|POLN_HEVMY Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) OX=31769
GN=ORF1 PE=1 SV=1
Length=1693
Score = 53.2 bits (126), Expect = 8e-05, Method: Composition-based stats.
Identities = 23/109 (21%), Positives = 39/109 (36%), Gaps = 11/109 (10%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLH 1094
+VNA+N+ + GGG+ A + + S G + + +H
Sbjct 803 LVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRD-------GAAAYT---LTPRPIIH 852
Query 1095 VVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQV 1142
V P+ + + L+AAY S+ LL GI+ S
Sbjct 853 AVAPDYRLEHNPKRLEAAYRETCSRLGTAAYSLLGTGIYQVPIGPSFDA 901
>sp|Q9IVZ9|POLN_HEVCT Non-structural polyprotein pORF1 OS=Hepatitis
E virus genotype 4 (isolate Human/China/T1) OX=509627
GN=ORF1 PE=3 SV=1
Length=1707
Score = 53.2 bits (126), Expect = 8e-05, Method: Composition-based stats.
Identities = 32/195 (16%), Positives = 54/195 (28%), Gaps = 36/195 (18%)
Query 1035 IVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGH----NLAK 1090
+VNA+N + GGG+ A ES D + G +
Sbjct 817 LVNASNPGHRPGGGLCHAFY-----QRFPESFD---------PAEFIMSDGFAAYTLTPR 862
Query 1091 KCLHVVGPNLNAGEDIQLLKAAYENFNSQ-DILLAPLLSAGIFGAKPLQSLQVCVQTVR- 1148
+H V P+ + + L+AAY S+ PLL GI+ S + R
Sbjct 863 PIIHAVAPDYRVEHNPKRLEAAYRETCSRRGTAAYPLLGVGIYRVPVGLSFDAWERNHRP 922
Query 1149 --------TQVYIAVNDKALYEQVVMDYLD--------NLKPRVEAPKQEEPPNTEDSKT 1192
+ ++ + + L E + E
Sbjct 923 GDELYLTEPAIAWFEANRPTLPALTITEDTARTANLALELDAATEVGRACVGCRVEPGVI 982
Query 1193 EEKSVVQKPVDVKPK 1207
+ P K +
Sbjct 983 HYQFTAGVPGSGKSR 997
>sp|P08411|POLN_SFV Polyprotein P1234 OS=Semliki forest virus
OX=11033 PE=1 SV=2
Length=2432
Score = 49.3 bits (116), Expect = 0.001, Method: Composition-based stats.
Identities = 35/153 (23%), Positives = 52/153 (34%), Gaps = 27/153 (18%)
Query 1037 NAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGSCLLSGHNLAKKCLHVV 1096
NAAN G GV A+ K A VG + + +H V
Sbjct 1357 NAANARGTVGDGVCRAVAKKWPSAF---------KGAATPVGTIKTVMCGSYP--VIHAV 1405
Query 1097 GPNLNAGEDIQ---LLKAAYENF------NSQDILLAPLLSAGIFGA------KPLQSLQ 1141
PN +A + + L A Y S + PLLS G+F + L L
Sbjct 1406 APNFSATTEAEGDRELAAVYRAVAAEVNRLSLSSVAIPLLSTGVFSGGRDRLQQSLNHLF 1465
Query 1142 VCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKP 1174
+ V I DK+ +E+ + + +D
Sbjct 1466 TAMDATDADVTIYCRDKS-WEKKIQEAIDMRTA 1497
>sp|P26627|R1AB_CVMJD Replicase polyprotein 1ab (Fragment) OS=Murine
coronavirus (strain defective JHM) OX=11143 GN=rep PE=3
SV=1
Length=500
Score = 45.5 bits (106), Expect = 0.011, Method: Composition-based stats.
Identities = 45/194 (23%), Positives = 74/194 (38%), Gaps = 19/194 (10%)
Query 1580 DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVG 1639
D+ K++ + E +T P+D T + + E+ Y + T F
Sbjct 323 DIEKVEDSILSELQTELNAPADKTYE-DVLAFDAIYSETLSAFYAVPSDETH---FKVC- 377
Query 1640 GLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV 1699
G S NC+L S L+ +Q L ++F +Q+ + +AG F ++ + K++
Sbjct 378 GFYSPAIERTNCWLRSTLIVMQSLPLEFKDLGMQKLWLSYKAGYDQCFVDKLVKSAPKSI 437
Query 1700 GEL--GDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLK 1757
G V + L S K N C CG L G++AV + G +
Sbjct 438 ILPQGGYVADFAYFFLSQ---CSFKVHANWRCLKCGM-ELKLQGLDAVFFYGDV------ 487
Query 1758 TGVSIPCVCGRDAT 1771
VS C C A
Sbjct 488 --VSHMCKCSFKAY 499
>sp|Q5UQ32|RPO6_MIMIV DNA-directed RNA polymerase subunit 6 OS=Acanthamoeba
polyphaga mimivirus OX=212035 GN=MIMI_R209 PE=3
SV=1
Length=396
Score = 40.9 bits (94), Expect = 0.27, Method: Composition-based stats.
Identities = 21/80 (26%), Positives = 35/80 (44%), Gaps = 6/80 (8%)
Query 927 PPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDD-- 984
PD+E +D+ + ID E EY T+ D + P++ E E+EED ++D
Sbjct 62 APDDELGEDSATLD--IDPDDEAEYDTDGDEKFNPIDEMGEPEDPDDPSEQEEDEVEDLG 119
Query 985 --TTEQSEIEPEPEPTPEEP 1002
+ EIE + +
Sbjct 120 SEDVDNVEIEDDAADIEDLD 139
>sp|Q4FRM3|RS20_PSYA2 Small ribosomal subunit protein bS20 OS=Psychrobacter
arcticus (strain DSM 17307 / VKM B-2377 / 273-4)
OX=259536 GN=rpsT PE=3 SV=1
Length=88
Score = 37.0 bits (84), Expect = 0.40, Method: Composition-based stats.
Identities = 18/82 (22%), Positives = 38/82 (46%), Gaps = 6/82 (7%)
Query 3933 AYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQ--RK----LEKMADQAM 3986
A A++ ++ + +++ K ++ A + D DAA + +K L++MAD+ +
Sbjct 7 ARKRARQNTKRRQNSASQRSMVRTYLKRVDAAIAAKDYDAATEAYKKAVPVLDRMADKGI 66
Query 3987 TQMYKQARSEDKRAKVTSAMQT 4008
K AR + + K +Q
Sbjct 67 LHKNKAARRKSRLNKTIKGLQA 88
>sp|Q91ZC6|MRGA6_MOUSE Mas-related G-protein coupled receptor
member A6 OS=Mus musculus OX=10090 GN=Mrgpra6 PE=2 SV=2
Length=301
Score = 39.7 bits (91), Expect = 0.47, Method: Composition-based stats.
Identities = 22/151 (15%), Positives = 48/151 (32%), Gaps = 10/151 (7%)
Query 3643 WLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDDAARR-----VWTLMNVITLVYK 3697
+ ++G + + L ++ + R + +W L ++ ++Y+
Sbjct 84 YTFRVLLYIAGLNMLSAISIERCLSVMCPIWYRCHRPEHTSTVMCAMIWVLSLLLCILYR 143
Query 3698 VYYG-----NALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNT 3752
+ G D + + + VV + LA C L T
Sbjct 144 YFCGFLDTKYEDDYGCLAMNFLTTAYLMFLFVVLCVSSLALLARLFCGAGRMKLTRLYVT 203
Query 3753 LQCIMLVYCFLGYCCCCYFGLFCLLNRYFRL 3783
+ +LV+ G C Y+ L + F +
Sbjct 204 ITLTLLVFLLCGLPCGFYWFLLSKIKNVFSV 234
>sp|Q2FQC0|KUP_METHJ Probable potassium transport system protein
Kup OS=Methanospirillum hungatei JF-1 (strain ATCC 27890
/ DSM 864 / NBRC 100397 / JF-1) OX=323259 GN=kup PE=3 SV=1
Length=611
Score = 40.5 bits (93), Expect = 0.48, Method: Composition-based stats.
Identities = 24/133 (18%), Positives = 45/133 (34%), Gaps = 8/133 (6%)
Query 2998 VDAMNLIANIFTPLVQPVGALDVSASVV--------AGGIIAILVTCAAYYFMKFRRVFG 3049
++I T + P+ +D ++ + ++ I V C F R+
Sbjct 313 SGIFSIIYQAITTHLLPMLPVDYTSDELRTQIYINTVNWLLCIAVICVLLIFQYSERLAS 372
Query 3050 EYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMF 3109
Y V + + L G+ + L YF + VS + H + ++
Sbjct 373 AYGLAVTGTMSITGSFMIAIFLQRRKYLYMGIALIVTLVDITYFLSTVSKITHGGYLSLV 432
Query 3110 SPIVPFWITAIYV 3122
+PF I IY
Sbjct 433 IAAIPFTIVIIYT 445
>sp|Q3KNA1|MRGB2_MOUSE Mas-related G-protein coupled receptor
member B2 OS=Mus musculus OX=10090 GN=Mrgprb2 PE=2 SV=2
Length=338
Score = 40.1 bits (92), Expect = 0.49, Method: Composition-based stats.
Identities = 30/203 (15%), Positives = 65/203 (32%), Gaps = 12/203 (6%)
Query 3588 FLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELA 3647
FL + A + L +LC + L Y ++ + ++ ++
Sbjct 61 FLGIRMHTNAFTVYILNLAMADFLYLCSQFVICLLIAFY---IFYSIDINIPLVLYVVPI 117
Query 3648 DTSLSGYRLKDCVMYASALVLLILMTARTVYDD-----AARRVWTLMNVITLVYKVYYGN 3702
LSG + + L ++ + R +W + ++ L+ G
Sbjct 118 FAYLSGLSILSTISIERCLSVIWPIWYRCKRPRHTSAITCFVLWVMSLLLGLLEGKACGL 177
Query 3703 ALDQAISMWALVISVTSNYSGVVTTIM----FLARAIVFVCVEYYPLLFITGNTLQCIML 3758
+ S W V +N VV + L + C + T+ +L
Sbjct 178 LFNSFDSYWCETFDVITNIWSVVFFGVLCGSSLTLLVRIFCGSQRIPMTRLYVTITLTVL 237
Query 3759 VYCFLGYCCCCYFGLFCLLNRYF 3781
V+ G Y+ L+ ++ ++
Sbjct 238 VFLIFGLPFGIYWILYQWISNFY 260
>sp|B9JA28|ATP6_RHIR8 ATP synthase subunit a OS=Rhizobium rhizogenes
(strain K84 / ATCC BAA-868) OX=311403 GN=atpB PE=3 SV=1
Length=250
Score = 39.3 bits (90), Expect = 0.60, Method: Composition-based stats.
Identities = 30/163 (18%), Positives = 57/163 (35%), Gaps = 21/163 (13%)
Query 3555 GTHHWMLLTFLTSLLILVQSTQ----WSLFFFVYENAFLPFTLGIMAIAACAML-LVKHK 3609
GT + SL + V + F+ V + F L ++ I + +KH
Sbjct 78 GTKGMKFFPLVFSLFMFVLTANLLGMVPYFYTVTSQIIVTFALALLVILTVILYGFIKHG 137
Query 3610 HAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGY------- 3654
FL LF LLP + + + + P S +R+ + +L +
Sbjct 138 FGFLKLFVPQGVPGILLPLVVIIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVASL 197
Query 3655 -RLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L + + L L++ + + A + V+T +Y
Sbjct 198 GTLGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY 240
>sp|Q1RGZ3|ATP6_RICBR ATP synthase subunit a OS=Rickettsia bellii
(strain RML369-C) OX=336407 GN=atpB PE=3 SV=1
Length=242
Score = 38.9 bits (89), Expect = 0.64, Method: Composition-based stats.
Identities = 26/148 (18%), Positives = 52/148 (35%), Gaps = 11/148 (7%)
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAML-LVKHKHAFLCLF-- 3616
++ T +L F V + + F L I+ ++ VKH FL LF
Sbjct 87 VIFTLFVFILFCNLFGMIPYGFTVTSHIIITFALAILVFLMVTIVGFVKHGMHFLSLFLP 146
Query 3617 ------LLPSLATVAYFNMVYMPASWVMRIMTWLE--LADTSLSGYRLKDCVMYASALVL 3668
L P + + F + PAS +R+ + + + ++Y L +
Sbjct 147 HGTPLWLAPLMIIIELFTYLARPASLSLRLAANMMAGHILLKVIASFVVTLMIYLKFLPI 206
Query 3669 LILMTARTVYDDAARRVWTLMNVITLVY 3696
+++ A + +++ VY
Sbjct 207 PLMVILIGFEIFVAILQAYIFTILSCVY 234
>sp|A8GUJ3|ATP6_RICB8 ATP synthase subunit a OS=Rickettsia bellii
(strain OSU 85-389) OX=391896 GN=atpB PE=3 SV=1
Length=242
Score = 38.9 bits (89), Expect = 0.65, Method: Composition-based stats.
Identities = 26/148 (18%), Positives = 52/148 (35%), Gaps = 11/148 (7%)
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAML-LVKHKHAFLCLF-- 3616
++ T +L F V + + F L I+ ++ VKH FL LF
Sbjct 87 VIFTLFVFILFCNLFGMIPYGFTVTSHIIITFALAILVFLMVTIVGFVKHGMHFLSLFLP 146
Query 3617 ------LLPSLATVAYFNMVYMPASWVMRIMTWLE--LADTSLSGYRLKDCVMYASALVL 3668
L P + + F + PAS +R+ + + + ++Y L +
Sbjct 147 HGTPLWLAPLMIIIELFTYLARPASLSLRLAANMMAGHILLKVIASFVITLMIYLKFLPI 206
Query 3669 LILMTARTVYDDAARRVWTLMNVITLVY 3696
+++ A + +++ VY
Sbjct 207 PLMVILIGFEIFVAILQAYIFTILSCVY 234
>sp|Q51151|LCBA_NEIMI Capsular polysaccharide phosphotransferase
OS=Neisseria meningitidis serogroup B OX=491 PE=3 SV=1
Length=373
Score = 39.3 bits (90), Expect = 0.73, Method: Composition-based stats.
Identities = 34/197 (17%), Positives = 66/197 (34%), Gaps = 15/197 (8%)
Query 841 RITFELDERVDKVLNEKCSVYTVESGT-EVTEFACVVAEAVVKTLQPVSDLLTNMGIDLD 899
+ E LN++ Y VE E EF + A+A + +L ++L N ID+
Sbjct 8 KFFRESHIFFRDFLNKRFPPYNVEQPIPETEEFTLINADANLASLTE--NVLPNFPIDV- 64
Query 900 EWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG 959
+ + D ++ + + Y + P D+E+ + E Y + +
Sbjct 65 ------VFTWVDNTDKAWQEQYYRTLQPIDQEDIGLYATDPARFSNHNELFYSVQAVQKF 118
Query 960 LPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIK 1019
+P V +++ WLD+ + + N+ K
Sbjct 119 MPW----VRNIFIVTADQKPKWLDENIHSKIKLINHSQLIDAKYLPTFNSHVIEANLY-K 173
Query 1020 CVDIVKEAQSANPMVIV 1036
D+ + N V V
Sbjct 174 IPDLSEHFIYFNDDVFV 190
>sp|B0R461|HTR6_HALS3 Transducer protein Htr6 OS=Halobacterium
salinarum (strain ATCC 29341 / DSM 671 / R1) OX=478009 GN=htr6
PE=1 SV=1
Length=789
Score = 39.3 bits (90), Expect = 1.0, Method: Composition-based stats.
Identities = 27/218 (12%), Positives = 68/218 (31%), Gaps = 7/218 (3%)
Query 830 TVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSD 889
++ EV D + ++ E+ + + ++ + +SD
Sbjct 523 SIQEVAASSATVAETAADAVERGEAGRDAAESAIDDMAEIESLSADAVDQILALQERMSD 582
Query 890 LLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEH 949
+ + D + E + + F E +D AE ++ +
Sbjct 583 IGDIIEFITDIAEQTNMLALNANIEAARADKDGDGFAVVANEVKDLAEETKQAAADIESE 642
Query 950 EYGTEDDYQGLPLEFGASAE-------TVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEP 1002
+ + + A++E TV ED +D + + E E+
Sbjct 643 IQAVQAETDETVADIRATSEHIDDGVSTVERAAAAIEDTVDAIEDANHGIQEISDATEDQ 702
Query 1003 VNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVIVNAAN 1040
+ ++ D+VA + ++A+ + +A+
Sbjct 703 ADATQSVVRRVDDVADISQHVTEDAEQVSAAAEEQSAS 740
>sp|P15576|NU1M_LEITA NADH-ubiquinone oxidoreductase chain 1 OS=Leishmania
tarentolae OX=5689 GN=ND1 PE=3 SV=1
Length=313
Score = 38.9 bits (89), Expect = 1.0, Method: Composition-based stats.
Identities = 28/234 (12%), Positives = 72/234 (31%), Gaps = 14/234 (6%)
Query 3552 IVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHK-- 3609
I + + +T+ I + + + F + + T+ + C+M
Sbjct 67 ISFDIIYLIGAMIITACCIFLGWFYFPIGFILLLDTGFTLTVMLCVHVFCSMFSTFFVGC 126
Query 3610 HAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELA------------DTSLSGYRLK 3657
F F+ S +F+++ +++ + ++ + +
Sbjct 127 FLFSSCFVYLSAMRTMFFSIISESGIFLLYTTIYSLDYFSFFGIKDVCVGQIYITNFYIA 186
Query 3658 DCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISV 3717
+ + V ++L + +D + +IT + ++ I+ L +
Sbjct 187 GVLFISVFWVSMLLDGLKLPFDYMECESELVAGLITELSGFFFVLYSVLEINHILLTTLL 246
Query 3718 TSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYF 3771
++ I F A I+ Y ++ + FL Y C F
Sbjct 247 FASLCFGGLFICFKAILILIFGFFYPRVIGYRLKITTAQAFILIFLFYMCVLMF 300
>sp|Q71SS4|DERL1_BOVIN Derlin-1 OS=Bos taurus OX=9913 GN=DERL1
PE=2 SV=1
Length=251
Score = 38.2 bits (87), Expect = 1.2, Method: Composition-based stats.
Identities = 36/183 (20%), Positives = 70/183 (38%), Gaps = 12/183 (7%)
Query 3621 LATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTART---- 3676
L + AYF + P +++ R W + T +Y L L + R
Sbjct 33 LISPAYFFLW--PEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRLETGA 90
Query 3677 VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIV 3736
A ++ L + + V G A+D + M L++SV ++ + ++
Sbjct 91 FDGRPADYLFML--LFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGT 148
Query 3737 FVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLVSTQE 3796
Y P + + N + ++ +G + F L+ RY + LG ++ +ST +
Sbjct 149 RFKACYLPWVILGFNYIIGGSVINELIGNLVGHLY--FFLMFRY-PMDLGGRNF-LSTPQ 204
Query 3797 FRY 3799
F Y
Sbjct 205 FLY 207
>sp|Q1RH22|Y1261_RICBR Uncharacterized lipoprotein RBE_1261 OS=Rickettsia
bellii (strain RML369-C) OX=336407 GN=RBE_1261 PE=3
SV=1
Length=1157
Score = 39.3 bits (90), Expect = 1.3, Method: Composition-based stats.
Identities = 28/178 (16%), Positives = 56/178 (31%), Gaps = 30/178 (17%)
Query 2992 SGVFCGVDAMNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEY 3051
G V A+ + +FT +G ++++ + I+ + V K F +Y
Sbjct 288 PGYRLSVSALLTLYIMFTGFSFLIGNINMTHVELVVRILKVSVVSILLSTSKAWTFFHDY 347
Query 3052 NHVVAANALLFLMS------------------------FTILCLVPAYSFLPGVYSV-FY 3086
V L ++ F++L + P +Y + Y
Sbjct 348 LFVFFVEGLAQILQIVQDASTGQSLLSLLISPQTLSKLFSLLFVDPLGFIYIILYLIALY 407
Query 3087 LYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMF 3144
F + +L L M + P +I + F N+LR+ + +
Sbjct 408 FIFLLIFKATIIYLTALITIGMIITMAPIFIC-----FMLFNITRSLFENWLRQLISY 460
>sp|Q9BUN8|DERL1_HUMAN Derlin-1 OS=Homo sapiens OX=9606 GN=DERL1
PE=1 SV=1
Length=251
Score = 38.2 bits (87), Expect = 1.3, Method: Composition-based stats.
Identities = 34/187 (18%), Positives = 70/187 (37%), Gaps = 10/187 (5%)
Query 3617 LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTART 3676
L+ L ++ + P +++ R W + T +Y L L + R
Sbjct 27 LVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYQYSTRL 86
Query 3677 ----VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLA 3732
A ++ L + + V G A+D + M L++SV ++ + ++
Sbjct 87 ETGAFDGRPADYLFML--LFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSF 144
Query 3733 RAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLV 3792
Y P + + N + ++ +G + F L+ RY + LG ++ +
Sbjct 145 WFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLY--FFLMFRY-PMDLGGRNF-L 200
Query 3793 STQEFRY 3799
ST +F Y
Sbjct 201 STPQFLY 207
>sp|Q67ES1|TR113_RAT Taste receptor type 2 member 113 OS=Rattus
norvegicus OX=10116 GN=Tas2r113 PE=3 SV=1
Length=309
Score = 38.5 bits (88), Expect = 1.4, Method: Composition-based stats.
Identities = 36/217 (17%), Positives = 72/217 (33%), Gaps = 31/217 (14%)
Query 2186 LCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRE 2245
+ L I++V+ K S + I L + I L L+ + VL +
Sbjct 27 IILMTCIDWVRRRKISLVDQILTALAITRITLILLVFIDWWVSVLFPALHET---GKILR 83
Query 2246 LYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPALETIQVTISSYKLDLTILGLAAEWV 2305
+Y S T ++ C S+ + + S+ ++ L + V
Sbjct 84 MYFIS--WTVINHCNLWLTASLSIIYFLKIASFSSI------------IFLYLKFRVKNV 129
Query 2306 LAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW-------------LMWFIISIVQMA 2352
+ L F+L +AI+ V+F N + F +
Sbjct 130 VFVTLLVSLFFLFINTAIVNVYFDVCFDGVQRNVSQVSRLYNHEQICKFLSFTNPMFAFI 189
Query 2353 PV-SAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMM 2388
P ++M ++ S + K+ H +GC + ++
Sbjct 190 PFVTSMATFFLLIFSLWRHLKNMKHNAEGCRDVSTIV 226
>sp|Q5R9W3|DERL1_PONAB Derlin-1 OS=Pongo abelii OX=9601 GN=DERL1
PE=2 SV=1
Length=251
Score = 38.2 bits (87), Expect = 1.4, Method: Composition-based stats.
Identities = 34/187 (18%), Positives = 70/187 (37%), Gaps = 10/187 (5%)
Query 3617 LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTART 3676
L+ L ++ + P +++ R W + T +Y L L + R
Sbjct 27 LVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYHYSTRL 86
Query 3677 ----VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLA 3732
A ++ L + + V G A+D + M L++SV ++ + ++
Sbjct 87 ETGAFDGRPADYLFML--LFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSF 144
Query 3733 RAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLV 3792
Y P + + N + ++ +G + F L+ RY + LG ++ +
Sbjct 145 WFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLY--FFLMFRY-PMDLGGRNF-L 200
Query 3793 STQEFRY 3799
ST +F Y
Sbjct 201 STPQFLY 207
>sp|Q37376|NU2M_ACACA NADH-ubiquinone oxidoreductase chain 2 OS=Acanthamoeba
castellanii OX=5755 GN=ND2 PE=3 SV=1
Length=527
Score = 38.5 bits (88), Expect = 1.4, Method: Composition-based stats.
Identities = 22/128 (17%), Positives = 52/128 (41%), Gaps = 5/128 (4%)
Query 3562 LTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLC-LFLLPS 3620
+ ++LL + S +S+F ++ A +P LG + + +K+K ++ LF++ S
Sbjct 402 INLFSNLLEVNPSLSFSIFILLFSIAGIPPLLGFYSKFFLFLFSLKYKMYWMTILFVIFS 461
Query 3621 LATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDD 3680
+ +V Y+ + + + R W+ L D + + + L ++
Sbjct 462 VVSVFYY-IRLVKLMYFNRTTGWIFLYDIPFLNSLIISFITIINCLF---FFNPNLLFKL 517
Query 3681 AARRVWTL 3688
+ L
Sbjct 518 IYNFSFYL 525
>sp|Q9TC94|YMF16_NEPOL Uncharacterized tatC-like protein ymf16
OS=Nephroselmis olivacea OX=31312 GN=YMF16 PE=3 SV=1
Length=247
Score = 37.8 bits (86), Expect = 1.5, Method: Composition-based stats.
Identities = 32/228 (14%), Positives = 74/228 (32%), Gaps = 12/228 (5%)
Query 3553 VKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAF 3612
+K ++ TFL +I ++ +FF+V+ L G + M H + F
Sbjct 12 IKYRFLYIFFTFLLCFIICTIYSESIMFFYVHPLINLTSMQG-KHLIFTEMSEAFHTYIF 70
Query 3613 LCLFLLPSLATVAYFNMVYM----PASWVMRIMTWLELADTSLSGYRLKDCVMYASAL-- 3666
LC F T YF + P+++ + L+ + ++Y L
Sbjct 71 LC-FFTSIYCTFPYFFYQFWAFFIPSTYQFERLQLRFLSFFFFTLLFFSCIIIYFIILPE 129
Query 3667 ----VLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYS 3722
L + R+ + + ++ ++ + ++L +++ +
Sbjct 130 IWSFFLHFEKKSYYFNLQLEARISSYIQFTFQIFSYFFVLFQCPLFTHFSLNLNLLTISF 189
Query 3723 GVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCY 3770
V + ++ P + I+ +Y + C Y
Sbjct 190 LVNSRKYIYFLFLILAAFLSPPDILSQFFLFSLIVFMYELCVFYSCFY 237
>sp|Q92JP0|ATP6_RICCN ATP synthase subunit a OS=Rickettsia conorii
(strain ATCC VR-613 / Malish 7) OX=272944 GN=atpB PE=3
SV=1
Length=242
Score = 37.8 bits (86), Expect = 1.6, Method: Composition-based stats.
Identities = 34/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTTTSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + I++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|A8F0C9|ATP6_RICM5 ATP synthase subunit a OS=Rickettsia massiliae
(strain Mtu5) OX=416276 GN=atpB PE=3 SV=2
Length=242
Score = 37.8 bits (86), Expect = 1.6, Method: Composition-based stats.
Identities = 34/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTTTSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLTVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + ++M A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPLMMILIGFEIFVAILQAYIFTILSCMY 234
>sp|C3PM51|ATP6_RICAE ATP synthase subunit a OS=Rickettsia africae
(strain ESF-5) OX=347255 GN=atpB PE=3 SV=1
Length=242
Score = 37.8 bits (86), Expect = 1.6, Method: Composition-based stats.
Identities = 33/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF ++ ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLIFSLFIFILFCNLLGMT--------PYSFTTTSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLMVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + I++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|Q99J56|DERL1_MOUSE Derlin-1 OS=Mus musculus OX=10090 GN=Derl1
PE=1 SV=1
Length=251
Score = 37.8 bits (86), Expect = 1.7, Method: Composition-based stats.
Identities = 34/187 (18%), Positives = 68/187 (36%), Gaps = 10/187 (5%)
Query 3617 LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTART 3676
L+ L ++ P +++ R W T +Y L L + R
Sbjct 27 LIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRL 86
Query 3677 ----VYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLA 3732
A ++ L + + V G A+D + M L++SV ++ + ++
Sbjct 87 EAGAFDGRPADYLFML--LFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSF 144
Query 3733 RAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYDYLV 3792
Y P + + N + ++ +G + F L+ RY + LG ++ +
Sbjct 145 WFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLY--FFLMFRY-PMDLGGRNF-L 200
Query 3793 STQEFRY 3799
ST +F Y
Sbjct 201 STPQFLY 207
>sp|P04540|NU5M_TRYBB NADH-ubiquinone oxidoreductase chain 5 OS=Trypanosoma
brucei brucei OX=5702 GN=ND5 PE=3 SV=1
Length=590
Score = 38.5 bits (88), Expect = 1.7, Method: Composition-based stats.
Identities = 18/125 (14%), Positives = 45/125 (36%), Gaps = 6/125 (5%)
Query 3024 VVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYS 3083
+V I + + ++ + F +F ++ V + L +F + + + L +
Sbjct 456 LVYCLISLYMCILSIFFIIDFVCIFVFSSYCVFWSFFLNFYNFFDIAIFVVFLILSVGF- 514
Query 3084 VFYLYLTFYFTNDVSFLAHLQ--WFAMFSPIVPFWITAIYVFCISLKHCH--WFFNNYLR 3139
Y F++ ++ + +F + +V Y C+ + W F Y R
Sbjct 515 -LYYGCLFFYFFNIDCIMLFWRIFFVIIILVVFMIFCCWYFVCMIIFMLLFVWNFVIYFR 573
Query 3140 KRVMF 3144
+ +
Sbjct 574 YNLKY 578
Score = 37.0 bits (84), Expect = 4.8, Method: Composition-based stats.
Identities = 27/225 (12%), Positives = 66/225 (29%), Gaps = 39/225 (17%)
Query 3582 FVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIM 3641
F++ FL F L ++ I + ++ FL+ S+ Y+ + +
Sbjct 19 FMFGRNFLSFWLSLVMIIFIVLCMI-------FSFLMVSVCLYGYYYYDFCLILMLDFCF 71
Query 3642 TWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDD-------AARRVWTLM-NVIT 3693
WL SG+ + ++ ++ +Y D ++ + N+
Sbjct 72 IWLTYV---CSGFYMFIMLLINMVFCFIVFYAFYYMYFDMLLGRFLIIFWIFVVCMNLFI 128
Query 3694 LVYKVYYGNALDQAISMWALVISVTSNYSGVV---------------------TTIMFLA 3732
L Y + + +++ + Y +I+FL+
Sbjct 129 LSYDFLTAYCGWELLGLFSFFLISYFWYRFFALKFGFKAFFIGKIGDVLLIFAFSIIFLS 188
Query 3733 RAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLL 3777
+ + ++ + + + FGL L
Sbjct 189 NGFCMTTFYFLNFFCMDYYYIEFSICLLVGCAFTKSTQFGLHIWL 233
>sp|Q03F26|TIG_PEDPA Trigger factor OS=Pediococcus pentosaceus
(strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w) OX=278197
GN=tig PE=3 SV=1
Length=435
Score = 38.2 bits (87), Expect = 1.7, Method: Composition-based stats.
Identities = 37/291 (13%), Positives = 90/291 (31%), Gaps = 21/291 (7%)
Query 710 IAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEAL-ET 768
K + + +++ + K ++ + + + +G ++ +
Sbjct 121 YKGVKVIKQSTRVTSKEVDEEIEKKREQQAELVLKEGKPAENGDTVTIDFDGSVDGVAFD 180
Query 769 PVDSFTNGAIVGTPVCV---NGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVT 825
+ ++G+ + ++ D++ ++ L+G + V
Sbjct 181 GGKADNYDLVLGSNSFIPGFEDQLIGHNTDEDVDVNVT--FPDDYQAEDLQGKDALFKVK 238
Query 826 FGEDTVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQ 885
E E+ + ++DE VD + + K ++ + V+
Sbjct 239 IHEIKTKELPELDD-EFAKDVDEDVDSLEDLKVKTKEEIKSRKIQAASDAKETEAVQAAV 297
Query 886 PVSDLLTNMGIDLDEWSVATF--YLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEI 943
+++ L+E YL + ++ S MY E++ D E E
Sbjct 298 DNAEIAEIPEAMLNEDVDRQVNQYLANMQ-QQGISPEMYFQLTGSSEDQLRDQLREGAE- 355
Query 944 DETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPE 994
L LE AE + ++E + D EQ +E +
Sbjct 356 ----------NRVKTTLVLEAIVEAEKIDPSDDEVAAEIKDLAEQYGMEEK 396
>sp|C4K0P3|ATP6_RICPU ATP synthase subunit a OS=Rickettsia peacockii
(strain Rustic) OX=562019 GN=atpB PE=3 SV=1
Length=242
Score = 37.4 bits (85), Expect = 2.1, Method: Composition-based stats.
Identities = 34/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTATSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLIVTIVGFVKHGLRFLTLFLPHGTPLWLAPLIIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + I++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|A8GQF6|ATP6_RICRS ATP synthase subunit a OS=Rickettsia rickettsii
(strain Sheila Smith) OX=392021 GN=atpB PE=3 SV=1
Length=242
Score = 37.4 bits (85), Expect = 2.3, Method: Composition-based stats.
Identities = 34/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTATSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLIVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + I++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|B0BVU2|ATP6_RICRO ATP synthase subunit a OS=Rickettsia rickettsii
(strain Iowa) OX=452659 GN=atpB PE=3 SV=1
Length=242
Score = 37.4 bits (85), Expect = 2.3, Method: Composition-based stats.
Identities = 34/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTATSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLIVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + I++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPIMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|Q68XQ1|ATP6_RICTY ATP synthase subunit a OS=Rickettsia typhi
(strain ATCC VR-144 / Wilmington) OX=257363 GN=atpB PE=3
SV=1
Length=242
Score = 37.0 bits (84), Expect = 2.7, Method: Composition-based stats.
Identities = 25/152 (16%), Positives = 55/152 (36%), Gaps = 17/152 (11%)
Query 3561 LLTFLTSLLILVQSTQW----SLFFFVYENAFLPFTLGIMAIAACAML-LVKHKHAFLCL 3615
+ + SL I + F + + FTL ++ ++ +KH +FL L
Sbjct 84 FIPLVFSLFIFILFCNLLGMTPYSFTATSHIIVTFTLALLIFLTVTIVGFIKHGMSFLTL 143
Query 3616 F--------LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLS---GYRLKDCVMYAS 3664
F L P + + F + P S +R+ + L G+ + ++Y
Sbjct 144 FLPQGTPVWLAPLMIVIELFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVS-LMIYLK 202
Query 3665 ALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L + +++ A + +++ +Y
Sbjct 203 FLPIPLIVILIGFEIFVAILQAYIFTILSCMY 234
>sp|Q09887|YC9D_SCHPO Uncharacterized amino-acid permease C584.13
OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=SPCC584.13 PE=3 SV=1
Length=544
Score = 37.8 bits (86), Expect = 2.8, Method: Composition-based stats.
Identities = 36/194 (19%), Positives = 71/194 (37%), Gaps = 11/194 (6%)
Query 3547 GKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLV 3606
G ++ + W S+L L+ S +++ + A P + IA + V
Sbjct 32 GYKQEFKREFSAWTSFCVSFSVLGLLPSFASTMY-YTTGYAGTPAMVWGWLIAMVFVQCV 90
Query 3607 KHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASAL 3666
+ A LC +P+ + Y V P W WL L V Y+ A
Sbjct 91 ANGMAELCS-SMPTSGGLYYAAAVLAPKGW-GPFAAWLTGWSNYLVQVTGPPSVAYSFAG 148
Query 3667 VLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVT 3726
++L L+ + L+ V ++ + + + + ++++ N G V
Sbjct 149 MILTLVQLHNPNFETQNYQIFLLAVAAMIAQGFISSMPTKVLAVF--------NTWGTVL 200
Query 3727 TIMFLARAIVFVCV 3740
++FLA ++ V
Sbjct 201 NMLFLAIVMITVLA 214
>sp|Q1QA59|RS20_PSYCK Small ribosomal subunit protein bS20 OS=Psychrobacter
cryohalolentis (strain ATCC BAA-1226 / DSM 17306
/ VKM B-2378 / K5) OX=335284 GN=rpsT PE=3 SV=1
Length=88
Score = 34.7 bits (78), Expect = 3.0, Method: Composition-based stats.
Identities = 17/84 (20%), Positives = 42/84 (50%), Gaps = 9/84 (11%)
Query 3933 AYATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQ--RK----LEKMADQAM 3986
A A++ ++ + +++ K ++ A + D DAA + +K L++MAD+ +
Sbjct 7 ARKRARQNTKRRQNSASQRSMVRTYLKRVDAAIAAKDYDAATEAYKKAVPVLDRMADKGI 66
Query 3987 TQMYKQARSEDKRAKVTSAMQTML 4010
K AR +++++ ++ +L
Sbjct 67 LHKNKAAR---RKSRLNKTIKGLL 87
>sp|Q00167|VG78_ICHVA Putative zinc-binding protein ORF78 OS=Ictalurid
herpesvirus 1 (strain Auburn) OX=766178 GN=ORF78 PE=4
SV=1
Length=400
Score = 37.4 bits (85), Expect = 3.0, Method: Composition-based stats.
Identities = 23/94 (24%), Positives = 38/94 (40%), Gaps = 10/94 (11%)
Query 2912 DTNLLEGSISYSELRPDTRYVLMDGSIIQF--PNTYL---EGSVRVVTTFD--AEYCRHG 2964
DT ++ G S +RPD+ + ++F P +G T C
Sbjct 32 DTGIVPGLRVESSVRPDSITNFRRLAAVKFKNPEVMECGGKGGCEECKTRPALMLNC--- 88
Query 2965 TCERSEVGICLSTSGRWVLNNEHYRALSGVFCGV 2998
C+ ++V ICL R V ++ +R + V CG
Sbjct 89 DCDTAKVPICLGCKPRAVRDHPCFRNRTCVSCGT 122
>sp|Q4UNH7|ATP6_RICFE ATP synthase subunit a OS=Rickettsia felis
(strain ATCC VR-1525 / URRWXCal2) OX=315456 GN=atpB PE=3
SV=1
Length=242
Score = 36.6 bits (83), Expect = 3.4, Method: Composition-based stats.
Identities = 33/175 (19%), Positives = 64/175 (37%), Gaps = 22/175 (13%)
Query 3534 FDVVRQCSGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTL 3593
D++ Q GV + KF +V ++L L + F + + FTL
Sbjct 70 ADMLNQNIGVKGR-KFIPLVFSLFIFILFCNLLGMT--------PYSFTATSHIIVTFTL 120
Query 3594 GIMAIAACAML-LVKHKHAFLCLF--------LLPSLATVAYFNMVYMPASWVMRIMTWL 3644
I+ ++ VKH FL LF L P + + F + P S +R+ +
Sbjct 121 AILVFLTVTIVGFVKHGLRFLTLFLPHGTPLWLAPLMIVIELFTYLARPVSLSLRLAANM 180
Query 3645 ELADTSLS---GYRLKDCVMYASALVLLILMTARTVYDDAARRVWTLMNVITLVY 3696
L G+ + ++Y L + +++ A + +++ +Y
Sbjct 181 MAGHVLLKVIAGFTVS-LMIYLKFLPIPLMVILIGFEIFVAILQAYIFTILSCMY 234
>sp|Q4WFQ4|ABCH_ASPFU ABC multidrug transporter H OS=Aspergillus
fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100
/ Af293) OX=330879 GN=abcH PE=1 SV=2
Length=1424
Score = 37.8 bits (86), Expect = 3.6, Method: Composition-based stats.
Identities = 37/215 (17%), Positives = 80/215 (37%), Gaps = 17/215 (8%)
Query 3621 LATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYDD 3680
L FN +++ + ++ L + + R K MY+ + L+ + Y
Sbjct 1157 LKLFTIFNFIFVAPGVINQLQP-LFIERRDIYDAREKKSKMYSWVAFVTALIVSEFPYLC 1215
Query 3681 AARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIMFLARAIVFVCV 3740
++ + Y V + + D+A +++ +++ Y+G+ I A F +
Sbjct 1216 VCAVLYFVC----WYYTVGFPSDSDKAGAIFFIMLCYEFLYTGIGQFIAAYAPNATFAAL 1271
Query 3741 EYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY-----FRLTLGVYDYLVSTQ 3795
PL+ T + +++ Y + Y+ LN + L V+D V +
Sbjct 1272 T-NPLILGTLVSFCGVLVPYAQIQAFWR-YW--IYWLNPFNYLMGSMLVFSVFDTDVKCK 1327
Query 3796 EFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCI 3830
E + P + A L+ L G+G + +
Sbjct 1328 EGEFAV---FDTPNGTTCADYLSTYLQGVGSRANL 1359
>sp|Q6Q487|CALX_ASPFU Calnexin homolog OS=Aspergillus fumigatus
(strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) OX=330879
GN=AFUA_4G12850 PE=2 SV=2
Length=563
Score = 37.4 bits (85), Expect = 3.8, Method: Composition-based stats.
Identities = 20/87 (23%), Positives = 33/87 (38%), Gaps = 1/87 (1%)
Query 912 AGEENFSSRMYCSFYPP-DEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAET 970
GE + + F PP + E+E D +++ D E + + + + A E
Sbjct 230 DGEAVKNGTLLEDFAPPVNPEKEIDDPKDKKPADWVDEAKIPDPEAKKPDDWDEDAPYEI 289
Query 971 VRVEEEEEEDWLDDTTEQSEIEPEPEP 997
V E EDWL+D +P
Sbjct 290 VDEEATMPEDWLEDEPTSIPDPEAEKP 316
>sp|Q12UQ9|SYM_METBU Methionine--tRNA ligase OS=Methanococcoides
burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
OX=259564 GN=metG PE=3 SV=1
Length=684
Score = 37.4 bits (85), Expect = 3.8, Method: Composition-based stats.
Identities = 21/89 (24%), Positives = 31/89 (35%), Gaps = 5/89 (6%)
Query 292 KTEGFMGRIRSVYPVASPQECNNMHLSTL--MKCNHCDEVSWQTCDFLKATCEHCGTENL 349
T+ R+ V+ E ++ T+ C CD ++K TC HC E
Sbjct 99 TTDDPTNHNRTTEIVSKLIENGYVYPKTIEIAYCPSCDRS--LPDRYVKGTCPHCKKEAR 156
Query 350 VIEGPTTCG-YLPTNAVVKMPCPACQDPE 377
E CG +L + C C P
Sbjct 157 GDECDQGCGKHLEPGELEHPACTTCNGPA 185
>sp|P36819|VE7_HPV12 Protein E7 OS=Human papillomavirus 12 OX=10604
GN=E7 PE=3 SV=1
Length=103
Score = 34.7 bits (78), Expect = 4.1, Method: Composition-based stats.
Identities = 17/63 (27%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query 2015 NLACESQQPTSEEVVENPTIQKEVIE----CDVKTTEVVGNVILKPSDEGVKVTQELGHE 2070
+L CE + P +E E I + V + C + EV + + +D G++ Q+L
Sbjct 26 DLLCEEELPNEQETEEESDIDRTVFKIIAPCGCSSCEVNLRIFVNATDTGIRTLQDLLIS 85
Query 2071 DLM 2073
DL
Sbjct 86 DLQ 88
>sp|Q9UTG3|YKEE_SCHPO Uncharacterized protein C1805.14 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC1805.14
PE=4 SV=1
Length=452
Score = 37.0 bits (84), Expect = 4.2, Method: Composition-based stats.
Identities = 22/112 (20%), Positives = 40/112 (36%), Gaps = 3/112 (3%)
Query 912 AGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDE---TCEHEYGTEDDYQGLPLEFGASA 968
AGEE F + + + D E + EH++G EDD+ G +
Sbjct 97 AGEETFGQIERFEYLLSSDGDGDGDVEIENPEVDDYQVSEHDFGLEDDFNGDGCQQMIEI 156
Query 969 ETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC 1020
E+ EEEED ++ +S++ + + +T+
Sbjct 157 ESDEAISEEEEDLSNENKSESQLGESFSFNQDNTFVNYASPASITEEFVEPK 208
>sp|Q91ZC7|MRGA5_MOUSE Mas-related G-protein coupled receptor
member A5 OS=Mus musculus OX=10090 GN=Mrgpra5 PE=2 SV=2
Length=304
Score = 36.6 bits (83), Expect = 4.2, Method: Composition-based stats.
Identities = 42/261 (16%), Positives = 85/261 (33%), Gaps = 34/261 (13%)
Query 3560 MLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKHKHAFLCLFLLP 3619
M++ F + W L F ++ NAF + +A+A LL H + LL
Sbjct 18 MIIIFRLVGMTGNAIVFWLLGFSLHRNAF-SVYILNLALADFVFLLC---HIIDSMLLL- 72
Query 3620 SLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALVLLILMTARTVYD 3679
TV Y N ++ + + + ++G + + L +L + R +
Sbjct 73 --LTVFYPNNIFSGYFYTI-------MTVPYIAGLSMLSAISTELCLSVLCPIWYRCHHP 123
Query 3680 DAARR-----VWTLMNVITLVYKVY-----YGNALDQAISMWALVISVTSNYSGVVTTIM 3729
+ +W L ++ ++ + + D+ + VV +
Sbjct 124 EHTSTVMCAAIWVLPLLVCILNRYFCSFLDINYNNDKQCLASNFFTRAYLMFLFVVLCLS 183
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRYFRLTLGVYD 3789
+A C L T+ +L + G Y+ L + F L +D
Sbjct 184 SMALLARLFCGTGQMKLTRLYVTIMLTVLGFLLCGLPFVIYYFLLFNIKDGFCL----FD 239
Query 3790 YLVSTQEFRYMNSQGLLPPKS 3810
+ YM++ L +
Sbjct 240 FRF------YMSTHVLTAINN 254
>sp|A8GLV8|ATP6_RICAH ATP synthase subunit a OS=Rickettsia akari
(strain Hartford) OX=293614 GN=atpB PE=3 SV=1
Length=242
Score = 36.6 bits (83), Expect = 4.4, Method: Composition-based stats.
Identities = 28/157 (18%), Positives = 51/157 (32%), Gaps = 20/157 (13%)
Query 3561 LLTFLTSLLILVQSTQW----SLFFFVYENAFLPFTLGIMAIAACAML-LVKHKHAFLCL 3615
+ + SL I V + F + + FTL I+ ++ VKH FL L
Sbjct 84 FIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTLAIIVFLTVTIVGFVKHGLRFLTL 143
Query 3616 F--------LLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCVMYASALV 3667
F L P + + F + P S +R+ + L V+ +
Sbjct 144 FLPYGTPLWLAPLMIVIELFTYLAKPVSLSLRLAANMMAGHVLLK-------VIAGFTVS 196
Query 3668 LLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNAL 3704
L+I + + + + I Y + +
Sbjct 197 LMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCM 233
>sp|Q86X53|ERIC1_HUMAN Glutamate-rich protein 1 OS=Homo sapiens
OX=9606 GN=ERICH1 PE=1 SV=1
Length=443
Score = 37.0 bits (84), Expect = 4.5, Method: Composition-based stats.
Identities = 23/99 (23%), Positives = 35/99 (35%), Gaps = 5/99 (5%)
Query 926 YPPDEEEEDDAECEE--EEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLD 983
P EE+ DA E+ + I+E E+D + E GA A EE+ D
Sbjct 259 TPAGEEDVKDAREEDGVDTIEEDLTRAG--EEDGKDTREEDGADASEEDPTWAGEEEGAD 316
Query 984 DTTEQS-EIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCV 1021
E + E + E + +LK T +
Sbjct 317 SGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDG 355
>sp|Q864G6|MSHR_ALOSE Melanocyte-stimulating hormone receptor
OS=Alouatta seniculus OX=9503 GN=MC1R PE=3 SV=1
Length=317
Score = 36.6 bits (83), Expect = 4.9, Method: Composition-based stats.
Identities = 46/234 (20%), Positives = 85/234 (36%), Gaps = 23/234 (10%)
Query 2210 LLLLSICLGSLICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICL 2269
L LS L S + +L+ GA + V + N+ +V T C S CS+C
Sbjct 79 CLALSDLLVSGSNMLETAVILMLEAGALATRASVVQQLQNTIDVLT---CS-SMLCSLCF 134
Query 2270 SGLDSLDSYPAL-------ETIQVTISSYKLDLTILG--LAAEWVLAY------MLFTKF 2314
G +LD Y ++ + + + + T + L++ +AY +L
Sbjct 135 LGAIALDRYVSIFYALRYHSIVTLPRARRAIAATWVASVLSSTLFIAYCDHAAVLLCLVV 194
Query 2315 FYLLGLSAIMQVFFGYFA---SHFISNSWLMWFIISIVQMAPVSAMVRMYIFFASFYYIW 2371
F+L L + ++ A H + L + Q + + I F+ W
Sbjct 195 FFLAMLVLMAVLYVHMLARACQHAQGITRLHKRQLPAHQGFGLRGAATLTILLGIFFLCW 254
Query 2372 K-SYVHIMDGCTSSTCMMCYKRNRATRVECTTIVNGMKRSFYVYANGGRGFCKT 2424
++H+M + C + +V T I+ +YA + C+T
Sbjct 255 GPFFLHLMLVVLCPQHLTCSCIFKNFKVFLTLIICNTIIDPLIYAFRSQELCRT 308
>sp|Q5A1V3|POA1_CANAL ADP-ribose 1''-phosphate phosphatase OS=Candida
albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=POA1
PE=3 SV=2
Length=156
Score = 35.5 bits (80), Expect = 5.4, Method: Composition-based stats.
Identities = 27/140 (19%), Positives = 47/140 (34%), Gaps = 22/140 (16%)
Query 1016 VAIKCVDIVKEAQSANPMVIV-NAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGP 1074
+ D+ A A VI+ +A N H GGG+A A+ + E Y N
Sbjct 2 IQYIKGDLFTHAIPAGKKVILAHACNTHGSWGGGIA-AVFRKKFPKSNNEYSQYCHKNSN 60
Query 1075 LTVGGSCLLSGHNL---------------AKKCLHVVGPNLNAGEDIQLLKAAYENFNSQ 1119
L +G S ++ ++ +H + + + + E
Sbjct 61 L-LGTSFIIESDQPNILIACLFTSDFNQTPEQIVHFT--KQSIADLARKVSDYKEVEKCD 117
Query 1120 DILL--APLLSAGIFGAKPL 1137
+ P ++AGIFG
Sbjct 118 GKVAINMPKINAGIFGVPWE 137
>sp|Q8SR69|IPYR_ENCCU Inorganic pyrophosphatase OS=Encephalitozoon
cuniculi (strain GB-M1) OX=284813 GN=IPP1 PE=1 SV=1
Length=277
Score = 36.2 bits (82), Expect = 6.0, Method: Composition-based stats.
Identities = 32/173 (18%), Positives = 62/173 (36%), Gaps = 12/173 (7%)
Query 31 FGDSVEEALSEAREHLKNGTCGLVE---------LEKGVLPQL-EQPYVFIKRSDALSTN 80
F + EEA + ++ +K G V+ G LPQ E P+ + + A N
Sbjct 59 FEINKEEAFNPIKQDIKKGWPRFVKNVFPMKGYLWNYGALPQTWENPHEVDRHTGARGDN 118
Query 81 HGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNGNKGAGGHSYGIDL 140
V+E+ + + LG + V E ++ V++ N K +
Sbjct 119 DPLDVIEIGRKRKEVGEVYQAKVLGS-IALVDEGECDWKVVVIDVNDEKAKEINDIEDVR 177
Query 141 KSYDLGDELGTDPIEDYE-QNWNTKHGSGALRELTRELNGGAVTRYVDNNFCG 192
K Y+ E ++Y+ + K+ + + + + N+CG
Sbjct 178 KVYEGLLEQTIFWFKNYKVPDGKPKNNFALDGKYMDKKFTVGIIKSAYENWCG 230
>sp|D4AVD4|CALX_ARTBC Calnexin homolog ARB_00147 OS=Arthroderma
benhamiae (strain ATCC MYA-4681 / CBS 112371) OX=663331 GN=ARB_00147
PE=3 SV=1
Length=563
Score = 36.6 bits (83), Expect = 6.0, Method: Composition-based stats.
Identities = 24/121 (20%), Positives = 37/121 (31%), Gaps = 3/121 (2%)
Query 898 LDEWSVATFYLFDD--AGEENFSSRMYCSFYPP-DEEEEDDAECEEEEIDETCEHEYGTE 954
L V F GE + + F PP + +E D E + + D E +
Sbjct 216 LYTLIVNPDQTFQIRIDGEPLKNGTLLEDFTPPVNPPKEIDDEKDTKPADWVDEEKIPDP 275
Query 955 DDYQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTD 1014
+ + + A E V E + DWLDD +P +
Sbjct 276 EAKKPEDWDEDAPFEIVDTEATKPADWLDDEPTTIPDPEAVKPEDWDDEEDGDWIAPTVP 335
Query 1015 N 1015
N
Sbjct 336 N 336
>sp|P9WP37|QCRB_MYCTU Cytochrome bc1 complex cytochrome b subunit
OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
OX=83332 GN=qcrB PE=1 SV=1
Length=549
Score = 36.6 bits (83), Expect = 6.0, Method: Composition-based stats.
Identities = 31/131 (24%), Positives = 57/131 (44%), Gaps = 14/131 (11%)
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
F LG +A+ + +LL+ +L LF PS+ V Y N VY P V + D
Sbjct 44 SFLLGEIALYSFVVLLITGV--YLTLFFDPSMVDVTY-NGVYQPLRGVEMSRAYQSALDI 100
Query 3650 SLS---GYRLKDCVMYASALV--LLILMTARTVYDDAARRV----WTLMNVITLVYKV-- 3698
S G ++ +A+ + +++ AR + A RR W + +++ ++
Sbjct 101 SFEVRGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEG 160
Query 3699 YYGNALDQAIS 3709
Y+G +L +
Sbjct 161 YFGYSLPDDLL 171
>sp|P9WP36|QCRB_MYCTO Cytochrome bc1 complex cytochrome b subunit
OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
OX=83331 GN=qcrB PE=3 SV=1
Length=549
Score = 36.6 bits (83), Expect = 6.0, Method: Composition-based stats.
Identities = 31/131 (24%), Positives = 57/131 (44%), Gaps = 14/131 (11%)
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
F LG +A+ + +LL+ +L LF PS+ V Y N VY P V + D
Sbjct 44 SFLLGEIALYSFVVLLITGV--YLTLFFDPSMVDVTY-NGVYQPLRGVEMSRAYQSALDI 100
Query 3650 SLS---GYRLKDCVMYASALV--LLILMTARTVYDDAARRV----WTLMNVITLVYKV-- 3698
S G ++ +A+ + +++ AR + A RR W + +++ ++
Sbjct 101 SFEVRGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEG 160
Query 3699 YYGNALDQAIS 3709
Y+G +L +
Sbjct 161 YFGYSLPDDLL 171
>sp|P63886|QCRB_MYCBO Cytochrome bc1 complex cytochrome b subunit
OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
OX=233413 GN=qcrB PE=3 SV=1
Length=549
Score = 36.6 bits (83), Expect = 6.0, Method: Composition-based stats.
Identities = 31/131 (24%), Positives = 57/131 (44%), Gaps = 14/131 (11%)
Query 3590 PFTLGIMAIAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADT 3649
F LG +A+ + +LL+ +L LF PS+ V Y N VY P V + D
Sbjct 44 SFLLGEIALYSFVVLLITGV--YLTLFFDPSMVDVTY-NGVYQPLRGVEMSRAYQSALDI 100
Query 3650 SLS---GYRLKDCVMYASALV--LLILMTARTVYDDAARRV----WTLMNVITLVYKV-- 3698
S G ++ +A+ + +++ AR + A RR W + +++ ++
Sbjct 101 SFEVRGGLFVRQIHHWAALMFAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEG 160
Query 3699 YYGNALDQAIS 3709
Y+G +L +
Sbjct 161 YFGYSLPDDLL 171
>sp|F4KIB2|TMN8_ARATH Transmembrane 9 superfamily member 8 OS=Arabidopsis
thaliana OX=3702 GN=TMN8 PE=2 SV=1
Length=648
Score = 36.6 bits (83), Expect = 6.3, Method: Composition-based stats.
Identities = 23/151 (15%), Positives = 50/151 (33%), Gaps = 19/151 (13%)
Query 3011 LVQPVGALDVSASVVAGGI-IAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTI- 3068
+ PV ++ + + G + I + + + +F +FG + +V ++ T+
Sbjct 502 YMNPVFSILIGGILPFGAVFIELFFILTSIWLNQFYYIFG-FLFLVFVILIVTCAEITVV 560
Query 3069 LCLVP-----------AYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWI 3117
LC +Y +LY TFYF + + F ++
Sbjct 561 LCYFQLCSEDYLWWWRSYLTSGSSALYLFLYATFYFFTKLQITKLVSAMLYFG-----YM 615
Query 3118 TAIYVFCISLKHCHWFFNNYLRKRVMFNGVT 3148
L F+ R++++ V
Sbjct 616 LIASYAFFVLTGTIGFYACLWFTRLIYSSVK 646
>sp|P03318|POLN_MIDDV Polyprotein nsP1234 (Fragment) OS=Middelburg
virus OX=11023 PE=3 SV=2
Length=995
Score = 37.0 bits (84), Expect = 6.3, Method: Composition-based stats.
Identities = 19/78 (24%), Positives = 28/78 (36%), Gaps = 12/78 (15%)
Query 1109 LKAAYENFNSQ-----DILLAPLLSAGIFGA------KPLQSLQVCVQTVRTQVYIAVND 1157
L A Y S + PLLS G F + L L + T V I D
Sbjct 4 LAAVYRAVASLADETVRTMAIPLLSTGTFAGGKDRVLQSLNHLFTALDTTDVDVTIYCRD 63
Query 1158 KALYEQVVMDYLDNLKPR 1175
K+ +E+ + + +D
Sbjct 64 KS-WEKKIQEAIDMRTAT 80
>sp|Q12019|MDN1_YEAST Midasin OS=Saccharomyces cerevisiae (strain
ATCC 204508 / S288c) OX=559292 GN=MDN1 PE=1 SV=1
Length=4910
Score = 37.0 bits (84), Expect = 6.8, Method: Composition-based stats.
Identities = 23/75 (31%), Positives = 37/75 (49%), Gaps = 3/75 (4%)
Query 928 PDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVEEEEEEDWLDDTTE 987
PD+ +++ E+EE+ + E E+D G P E ET EEE E+ +D T +
Sbjct 4279 PDDLNKEEVGNEDEEVKQESGIESDNENDEPG-PEEDAGETETALDEEEGAEEDVDMTND 4337
Query 988 QSEIEPEPEPTPEEP 1002
+ + + E PEE
Sbjct 4338 EG--KEDEENGPEEQ 4350
>sp|O31352|MTAD_BACC1 5-methylthioadenosine/S-adenosylhomocysteine
deaminase OS=Bacillus cereus (strain ATCC 10987 / NRS 248)
OX=222523 GN=mtaD PE=3 SV=3
Length=435
Score = 36.2 bits (82), Expect = 7.5, Method: Composition-based stats.
Identities = 46/225 (20%), Positives = 70/225 (31%), Gaps = 20/225 (9%)
Query 859 SVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFS 918
S +T E TE + E V SD+ +G+D D +G
Sbjct 95 SQFTPELAVASTELG--LLEMVKSGTTSFSDMFNPIGVDQDAIMETV----SRSGMRAAV 148
Query 919 SRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASA--ETVRVEEE 976
SR SF D+E++ E E+ E T P E R+ E
Sbjct 149 SRTLFSFGTKDDEKKAIEEAEKYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVE 208
Query 977 EEEDW-LDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS---ANP 1032
+ + + + E+ + PV I ++ E + A
Sbjct 209 NQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIAHGVVLNENERAFLAEH 268
Query 1033 MVIV--NAANIHLKHGGGVAGALNKA---TNGAMQKESDDYIKLN 1072
V V N N +LK G G+ A KA + +D N
Sbjct 269 DVRVAHNP-NSNLKLGSGI--ANVKAMLEAGMKVGIATDSVASNN 310
>sp|Q7VRW4|NUON_BLOFL NADH-quinone oxidoreductase subunit N OS=Blochmannia
floridanus OX=203907 GN=nuoN PE=3 SV=1
Length=504
Score = 36.2 bits (82), Expect = 8.3, Method: Composition-based stats.
Identities = 34/225 (15%), Positives = 76/225 (34%), Gaps = 8/225 (4%)
Query 3556 THHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAACAMLLVKH-KHAFLC 3614
+ +++L + + W +++ VY + L I +I +++ H FL
Sbjct 77 SVLYVILIMFVGIASSILGYVWLVYYPVYRSDEFYLLLLIASIGGILLVITNHLIVLFLG 136
Query 3615 LFLLPSLATVAYFNMVYMPASWVMRI-MTWLELADTSLSGYRLKDCVMYASALVLL---- 3669
+ L+ V+ S + I L +S + + +L +
Sbjct 137 IELISISICGLISYPVFSKKSIELSIKYIILSGVSSSFLLFGIVFIYCKTGSLSFIDIKE 196
Query 3670 ILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSNYSGVVTTIM 3729
IL T V ++ TL ++ + + G + + L IS + ++
Sbjct 197 ILSTYNNVNHMLSQPSMTL--IVIGLSMMMIGMGFKLSCVPFHLWISDIYQGTPTAVSMY 254
Query 3730 FLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLF 3774
+ + V L I + ++ ++ + CC FG
Sbjct 255 LATGSKIAVTAVLMRFLLILPDQYNELLHIFLSVSACCSMLFGSL 299
>sp|Q9SJM4|STKLI_ARATH GLABROUS1 enhancer-binding protein-like
3 OS=Arabidopsis thaliana OX=3702 GN=GPL3 PE=1 SV=1
Length=414
Score = 35.8 bits (81), Expect = 9.1, Method: Composition-based stats.
Identities = 35/178 (20%), Positives = 66/178 (37%), Gaps = 4/178 (2%)
Query 817 GGAPIKGVTFGEDTVWEVQGYKNVRITFELDERVDKVLNEKCSVYTVESGTEVTEFACVV 876
G V E +V + R E+D V + L++ V VE E + CV
Sbjct 174 GEPETNDVPCEEQDDRDVPCEEQERANIEIDNGVREKLDQAKDVPCVEQ--ESEDVPCVE 231
Query 877 AEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDA 936
E V + + +D +E T L ++ G+++ + P EE+E +
Sbjct 232 QERVSIEIDNGEKEKLDQTMDCEE-QENTDVLCEEKGDKDVPCEEQENKDVPCEEQERVS 290
Query 937 ECEEEEIDETCEHEYGTEDD-YQGLPLEFGASAETVRVEEEEEEDWLDDTTEQSEIEP 993
+ +E E G ++ L+ G S + + +++ DD E ++
Sbjct 291 IEIDNGEEEMSSEEDGVDEVGVMEDTLDSGISFQGLGKNGVKDKSEEDDVVELGVLQE 348
>sp|B7IS56|MTAD_BACC2 5-methylthioadenosine/S-adenosylhomocysteine
deaminase OS=Bacillus cereus (strain G9842) OX=405531 GN=mtaD
PE=3 SV=1
Length=435
Score = 35.8 bits (81), Expect = 9.1, Method: Composition-based stats.
Identities = 46/225 (20%), Positives = 70/225 (31%), Gaps = 20/225 (9%)
Query 859 SVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFS 918
S +T E TE + E V SD+ +G+D D +G
Sbjct 95 SQFTPELAVASTELG--LLEMVKSGTTSFSDMFNPIGVDQDAIMETV----SRSGMRAAV 148
Query 919 SRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASA--ETVRVEEE 976
SR SF D+E++ E E+ E T P E R+ E
Sbjct 149 SRTLFSFGTKDDEKKAIEEAEKYVKRYYKESGMLTTMVAPHSPYTCSTELLEECARIAVE 208
Query 977 EEEDW-LDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQS---ANP 1032
+ + + + E+ + PV I ++ E + A
Sbjct 209 NQTMVHIHLSETEREVRDIEAQYGKRPVEYAASCGLFKRPTVIAHGVVLNENERAFLAEH 268
Query 1033 MVIV--NAANIHLKHGGGVAGALNKA---TNGAMQKESDDYIKLN 1072
V V N N +LK G G+ A KA + +D N
Sbjct 269 DVRVAHNP-NSNLKLGSGI--ANVKAMLEAGMKVGIATDSVASNN 310
>sp|P75354|DNAJM_MYCPN DnaJ-like protein MG200 homolog OS=Mycoplasma
pneumoniae (strain ATCC 29342 / M129 / Subtype 1) OX=272634
GN=MPN_119 PE=4 SV=1
Length=910
Score = 36.2 bits (82), Expect = 9.1, Method: Composition-based stats.
Identities = 21/126 (17%), Positives = 41/126 (33%), Gaps = 10/126 (8%)
Query 909 FDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQG--LPLEFGA 966
FD+AG+ + P D+ + + + E +D + P
Sbjct 248 FDEAGQWVWLEE-----TEPSSVSNDETTTDSDAVTAATTVEETDQDSWTANSAPEPVDV 302
Query 967 SAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKE 1026
E E E + ++E E P + + T +++ +V D+ E
Sbjct 303 ETPVELQPETEPEPIITLSSEPVEAPASVVIEPTPEIEETTSAVEMDASV---KADVSDE 359
Query 1027 AQSANP 1032
A + N
Sbjct 360 ADATNE 365
>sp|Q85BG0|NU4C_ANTAG NAD(P)H-quinone oxidoreductase chain 4,
chloroplastic OS=Anthoceros angustus OX=48387 GN=ndhD PE=2 SV=2
Length=501
Score = 35.8 bits (81), Expect = 9.9, Method: Composition-based stats.
Identities = 34/253 (13%), Positives = 77/253 (30%), Gaps = 28/253 (11%)
Query 3598 IAACAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLK 3657
+ M L+ H H+ P L + +VY S + + + S
Sbjct 261 LIRINMELLSHAHSIFA----PWLVVIGAIQIVY---SALTSLSQLNLKRRIAYSSVSHM 313
Query 3658 DCVMYASALVLLILMT---ARTVYDDAARRVWTLMNVITL-----VYKVYYGNALDQAIS 3709
V+ I + + + +T ++ G
Sbjct 314 GFVLIGIGSTTDIGVNGAILQMISHGLIGAALFFSAGVTYDRTRTLFLNQMGGIATSIPK 373
Query 3710 MWALVISVTSNYSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCC 3769
++ + S + + F+A ++F+ + + ++++ G
Sbjct 374 IFTMFSSFSMASLALPGLSGFVAELMIFLGIVSSQNFSFLF---KVVIIIVAATGIILTP 430
Query 3770 YFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPC 3829
+ L +L + F Y Y + Y+ G P+ L ++GIG P
Sbjct 431 IY-LLSMLRQMF------YGYRIIKNLTSYVTDAG---PREIFIFICLFFPIIGIGFYPK 480
Query 3830 IKVATVQSKMSDV 3842
+ ++ SK+ +
Sbjct 481 LVLSLSNSKVESI 493
>sp|P13830|RESA_PLAFF Ring-infected erythrocyte surface antigen
OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea)
OX=5837 GN=RESA PE=1 SV=1
Length=1073
Score = 36.2 bits (82), Expect = 9.9, Method: Composition-based stats.
Identities = 32/175 (18%), Positives = 56/175 (32%), Gaps = 9/175 (5%)
Query 864 ESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDEWSVATFYLFDDAGEENFSSRMYC 923
E G + + + + V D + D LFD ++ Y
Sbjct 371 EYGDILPSLRASITNSAINYYDTVKDGVYLDHETSDALYTDEDLLFDLEKQK------YM 424
Query 924 SFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGLPL---EFGASAETVRVEEEEEED 980
EEE + EE +D+ E+ +D++ P + TV E EE
Sbjct 425 DMLDTSEEESVEENEEEHTVDDEHVEEHTADDEHVEEPTVADDEHVEEPTVADEHVEEPT 484
Query 981 WLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKCVDIVKEAQSANPMVI 1035
++ E+ + E P V Q + + DI+ +A+ I
Sbjct 485 VAEEHVEEPTVAEEHVEEPASDVQQTSEAAPTIEIPDTLYYDILGVGVNADMNEI 539
Lambda K H a alpha
0.318 0.131 0.353 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0400 0.140 1.90 42.6 43.6
Effective search space used: 540007450114
Database: uniprot_sprot.fasta
Posted date: Apr 3, 2024 12:05 PM
Number of letters in database: 206,678,396
Number of sequences in database: 571,282
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40