Study Sample ID Cancer Type Protein Change Annotation Functional Impact Mutation Type Variant Type Copy # COSMIC MS VS Center Chromosome Start Pos End Pos Ref Var HGVSg HGVSc Allele Freq (T) Allele Freq (N) Variant Reads Ref Reads Variant Reads (Normal) Ref Reads (Normal) # Mut in Sample Exon gnomAD ClinVar dbSNP MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004699-T01-IM5 Lung Adenocarcinoma V155F OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.954 Missense_Mutation SNP diploid 3 NA NA NA 19 10610247 10610247 C A 19:g.10610247C>A ENST00000171111.5:c.463G>T 0.40 310 456 15 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007131-T01-IM5 Lung Adenocarcinoma V155F OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.954 Missense_Mutation SNP diploid 3 NA NA NA 19 10610247 10610247 C A 19:g.10610247C>A ENST00000171111.5:c.463G>T 0.23 135 444 11 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-18-3407-01 Lung Squamous Cell Carcinoma V155F OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.954 Missense_Mutation SNP gain 3 . . . 19 10610247 10610247 C A 19:g.10610247C>A ENST00000171111.5:c.463G>T 0.33 28 56 72 297 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-22-4599-01 Lung Squamous Cell Carcinoma V155F OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.954 Missense_Mutation SNP diploid 3 . . . 19 10610247 10610247 C A 19:g.10610247C>A ENST00000171111.5:c.463G>T 0.31 31 68 114 317 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-6776-01 Lung Adenocarcinoma V155A OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.76 Missense_Mutation SNP shallowdel 3 . . . 19 10610246 10610246 A G 19:g.10610246A>G ENST00000171111.5:c.464T>C 0.63 37 22 63 188 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AARE-01 Lung Adenocarcinoma V155F OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.954 Missense_Mutation SNP shallowdel 3 . . . 19 10610247 10610247 C A 19:g.10610247C>A ENST00000171111.5:c.463G>T 0.59 17 12 49 1197 2/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A230 Lung Adenocarcinoma R320L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.758 Missense_Mutation SNP shallowdel 3 NA NA NA 19 10602619 10602619 C A 19:g.10602619C>A ENST00000171111.5:c.959G>T 0.82 202 44 431 3/6 rs1239985410 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A143 Lung Adenocarcinoma G417V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP shallowdel 2 NA NA NA 19 10602328 10602328 C A 19:g.10602328C>A ENST00000171111.5:c.1250G>T 0.30 22 52 291 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007589-T01-IM5 Papillary Thyroid Cancer R260Q OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 3 NA NA NA 19 10602799 10602799 C T 19:g.10602799C>T ENST00000171111.5:c.779G>A 0.42 231 318 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000671-T01-IM3 Lung Adenocarcinoma G333C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 4 NA NA NA 19 10602581 10602581 C A 19:g.10602581C>A ENST00000171111.5:c.997G>T 0.70 462 199 38 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000807-T01-IM3 Lung Adenocarcinoma G333C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 4 NA NA NA 19 10602581 10602581 C A 19:g.10602581C>A ENST00000171111.5:c.997G>T 0.07 26 322 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002571-T01-IM3 Lung Adenocarcinoma G333C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 4 NA NA NA 19 10602581 10602581 C A 19:g.10602581C>A ENST00000171111.5:c.997G>T 0.44 247 316 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002731-T02-IM5 Lung Adenocarcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.62 663 403 10 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005700-T01-IM5 Large Cell Neuroendocrine Carcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.29 164 393 6 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008295-T01-IM5 Lung Adenocarcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.80 1023 250 6 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002969-T01-IM3 Lung Adenocarcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP diploid 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.34 170 324 20 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012084-T01-IM5 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP diploid 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.41 349 498 16 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000800-T01-IM3 Anaplastic Thyroid Cancer R320L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.758 Missense_Mutation SNP diploid 3 NA NA NA 19 10602619 10602619 C A 19:g.10602619C>A ENST00000171111.5:c.959G>T 0.50 169 171 18 3/6 rs1239985410 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006785-T01-IM5 Small Cell Lung Cancer R320L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.758 Missense_Mutation SNP diploid 3 NA NA NA 19 10602619 10602619 C A 19:g.10602619C>A ENST00000171111.5:c.959G>T 0.47 313 357 11 3/6 rs1239985410 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009379-T01-IM5 Lung Adenocarcinoma R320L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.758 Missense_Mutation SNP diploid 3 NA NA NA 19 10602619 10602619 C A 19:g.10602619C>A ENST00000171111.5:c.959G>T 0.12 116 872 8 3/6 rs1239985410 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004131-T01-IM5 Lung Adenocarcinoma R272C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.938 Missense_Mutation SNP diploid 2 NA NA NA 19 10602764 10602764 G A 19:g.10602764G>A ENST00000171111.5:c.814C>T 0.05 44 797 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011117-T01-IM5 Lung Adenocarcinoma R272C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.938 Missense_Mutation SNP diploid 2 NA NA NA 19 10602764 10602764 G A 19:g.10602764G>A ENST00000171111.5:c.814C>T 0.15 60 337 3 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003537-T02-IM5 Lung Adenocarcinoma R260L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10602799 10602799 C A 19:g.10602799C>A ENST00000171111.5:c.779G>T 0.56 219 174 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005808-T01-IM5 Renal Clear Cell Carcinoma R260L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10602799 10602799 C A 19:g.10602799C>A ENST00000171111.5:c.779G>T 0.24 147 473 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002758-T01-IM3 Lung Squamous Cell Carcinoma R272P OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.951 Missense_Mutation SNP diploid 2 NA NA NA 19 10602763 10602763 C G 19:g.10602763C>G ENST00000171111.5:c.815G>C 0.61 140 88 30 3/6 rs774469695 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009483-T01-IM5 Lung Adenocarcinoma R272H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.19;Polyphen-2: impact: benign, score: 0.023 Missense_Mutation SNP diploid 2 NA NA NA 19 10602763 10602763 C T 19:g.10602763C>T ENST00000171111.5:c.815G>A 0.06 43 707 10 3/6 rs774469695 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000344-T01-IM3 Lung Adenocarcinoma R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.32 167 350 5 6/6 0.00000397716 rs770453522 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001934-T01-IM3 Breast Invasive Ductal Carcinoma R320Q OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.889 Missense_Mutation SNP diploid 3 NA NA NA 19 10602619 10602619 C T 19:g.10602619C>T ENST00000171111.5:c.959G>A 0.13 54 368 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004875-T01-IM5 Lung Adenocarcinoma G417V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 NA NA NA 19 10602328 10602328 C A 19:g.10602328C>A ENST00000171111.5:c.1250G>T 0.11 80 660 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010602-T01-IM5 Large Cell Neuroendocrine Carcinoma G417V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 NA NA NA 19 10602328 10602328 C A 19:g.10602328C>A ENST00000171111.5:c.1250G>T 0.83 1163 235 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009559-T01-IM5 Lung Adenocarcinoma R272L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.793 Missense_Mutation SNP diploid 2 NA NA NA 19 10602763 10602763 C A 19:g.10602763C>A ENST00000171111.5:c.815G>T 0.42 376 524 9 3/6 rs774469695 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006979-T01-IM5 Lung Adenocarcinoma M110V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP diploid 2 NA NA NA 19 10610382 10610382 T C 19:g.10610382T>C ENST00000171111.5:c.328A>G 0.22 138 500 21 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008307-T01-IM5 Lung Adenocarcinoma M110V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP diploid 2 NA NA NA 19 10610382 10610382 T C 19:g.10610382T>C ENST00000171111.5:c.328A>G 0.12 62 464 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002605-T01-IM3 Lung Adenocarcinoma R601L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.917 Missense_Mutation SNP diploid 1 NA NA NA 19 10597401 10597401 C A 19:g.10597401C>A ENST00000171111.5:c.1802G>T 0.21 129 488 10 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002874-T01-IM3 Lung Adenocarcinoma R601L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.917 Missense_Mutation SNP diploid 1 NA NA NA 19 10597401 10597401 C A 19:g.10597401C>A ENST00000171111.5:c.1802G>T 0.52 452 417 13 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004335-T01-IM5 Lung Adenocarcinoma R601L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.917 Missense_Mutation SNP diploid 1 NA NA NA 19 10597401 10597401 C A 19:g.10597401C>A ENST00000171111.5:c.1802G>T 0.06 38 600 3 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011499-T01-IM5 Lung Adenocarcinoma R601L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.917 Missense_Mutation SNP diploid 1 NA NA NA 19 10597401 10597401 C A 19:g.10597401C>A ENST00000171111.5:c.1802G>T 0.22 210 752 8 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007978-T01-IM5 Lung Adenocarcinoma G480V OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 NA NA NA 19 10600416 10600416 C A 19:g.10600416C>A ENST00000171111.5:c.1439G>T 0.30 215 496 11 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006175-T01-IM5 Lung Adenocarcinoma M110I OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 NA NA NA 19 10610380 10610380 C A 19:g.10610380C>A ENST00000171111.5:c.330G>T 0.55 549 450 16 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007051-T01-IM5 Lung Adenocarcinoma M110I OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 NA NA NA 19 10610380 10610380 C A 19:g.10610380C>A ENST00000171111.5:c.330G>T 0.57 339 259 14 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003167-T01-IM5 Lung Adenocarcinoma G333F OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation DNP diploid 4 NA NA NA 19 10602580 10602581 CC AA 19:g.10602580_10602581delinsAA ENST00000171111.5:c.997_998delinsTT 0.11 59 462 28 3/6 Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccRCC_11 Renal Clear Cell Carcinoma with Sarcomatoid Features R260Q OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP 3 NA NA UTokyo 19 10602799 10602799 C T 19:g.10602799C>T ENST00000171111.5:c.779G>A 68 3/6 Metastatic Melanoma (DFCI, Nature Medicine 2019) Sample118 Melanoma G333S OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 4 NA NA NA 19 10602581 10602581 C T 19:g.10602581C>T ENST00000171111.5:c.997G>A 221 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-B02477 Lung Adenocarcinoma R260L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 3 Unknown NA broad.mit.edu 19 10602799 10602799 C A 19:g.10602799C>A ENST00000171111.5:c.779G>T 140 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-D01603 Lung Adenocarcinoma M110I OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10610380 10610380 C T 19:g.10610380C>T ENST00000171111.5:c.330G>A 699 2/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-NYU1021 Lung Adenocarcinoma R272P OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.951 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10602763 10602763 C G 19:g.10602763C>G ENST00000171111.5:c.815G>C 201 3/6 rs774469695 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01702 Lung Adenocarcinoma R272H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.19;Polyphen-2: impact: benign, score: 0.023 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10602763 10602763 C T 19:g.10602763C>T ENST00000171111.5:c.815G>A 477 3/6 rs774469695 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01818 Lung Adenocarcinoma R320M OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.957 Missense_Mutation DNP diploid 3 Unknown NA broad.mit.edu 19 10602619 10602620 CG AT 19:g.10602619_10602620delinsAT ENST00000171111.5:c.958_959delinsAT 324 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-S01409 Lung Adenocarcinoma R320P OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.977 Missense_Mutation SNP diploid 3 Unknown NA broad.mit.edu 19 10602619 10602619 C G 19:g.10602619C>G ENST00000171111.5:c.959G>C 575 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-U6SJ7 Lung Adenocarcinoma R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP shallowdel 1 Unknown NA broad.mit.edu 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 175 6/6 0.00000397716 rs770453522 Metastatic Breast Cancer (INSERM, PLoS Med 2016) MBC_145 Invasive Breast Carcinoma M110L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.992 Missense_Mutation SNP diploid 2 Somatic NA GR 19 10610382 10610382 T G 19:g.10610382T>G ENST00000171111.5:c.328A>C 0.22 48 170 133 246 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-39-5011-01 Lung Squamous Cell Carcinoma G333C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10602581 10602581 C A 19:g.10602581C>A ENST00000171111.5:c.997G>T 0.26 7 20 59 582 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-60-2722-01 Lung Squamous Cell Carcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 3 . . . 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.49 34 35 67 285 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-60-2710-01 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP diploid 8 . . . 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.33 20 40 61 194 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-66-2773-01 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP shallowdel 8 . . . 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.23 27 90 96 507 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-AASB-01 Lung Squamous Cell Carcinoma R320L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.758 Missense_Mutation SNP shallowdel 3 . . . 19 10602619 10602619 C A 19:g.10602619C>A ENST00000171111.5:c.959G>T 0.53 19 17 40 350 3/6 rs1239985410 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-66-2773-01 Lung Squamous Cell Carcinoma R320Q OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.889 Missense_Mutation SNP shallowdel 3 . . . 19 10602619 10602619 C T 19:g.10602619C>T ENST00000171111.5:c.959G>A 0.19 22 91 114 507 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-98-A539-01 Lung Squamous Cell Carcinoma R320Q OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.889 Missense_Mutation SNP shallowdel 3 . . . 19 10602619 10602619 C T 19:g.10602619C>T ENST00000171111.5:c.959G>A 0.44 16 20 45 166 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-AASD-01 Lung Squamous Cell Carcinoma R272L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.793 Missense_Mutation SNP shallowdel 2 . . . 19 10602763 10602763 C A 19:g.10602763C>A ENST00000171111.5:c.815G>T 0.55 18 15 76 322 3/6 rs774469695 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0077-R1 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.21 62 236 321 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0077-R2 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.42 94 128 326 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0077-R3 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.41 117 170 321 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0077-R4 Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.33 83 171 297 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0077-Pre-ctDNA Lung Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 18 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0017-R1 Non-Small Cell Lung Cancer R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.45 172 210 447 6/6 0.00000397716 rs770453522 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0017-R2 Non-Small Cell Lung Cancer R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.17 72 361 550 6/6 0.00000397716 rs770453522 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0017-R3 Non-Small Cell Lung Cancer R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.27 142 391 526 6/6 0.00000397716 rs770453522 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0017-R4 Non-Small Cell Lung Cancer R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.28 126 320 600 6/6 0.00000397716 rs770453522 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0017-Pre-ctDNA Non-Small Cell Lung Cancer R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 19 6/6 0.00000397716 rs770453522 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-ER-A19F-06 Cutaneous Melanoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 3 . . . 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.10 5 47 37 1662 4/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-EE-A2MR-06 Cutaneous Melanoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP gain 8 . . . 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.10 4 38 35 2920 4/6 Metastatic Melanoma (DFCI, Science 2015) Pat100 Cutaneous Melanoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP gain 8 Somatic Untested MSKCC 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.16 17 90 101 504 4/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CV-5434-01 Head and Neck Squamous Cell Carcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP shallowdel 8 . . . 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.55 16 13 53 131 4/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-5359-01 Head and Neck Squamous Cell Carcinoma R272C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.938 Missense_Mutation SNP shallowdel 2 . . . 19 10602764 10602764 G A 19:g.10602764G>A ENST00000171111.5:c.814C>T 0.12 10 76 122 134 3/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-DQ-7588-01 Head and Neck Squamous Cell Carcinoma R470H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.956 Missense_Mutation SNP shallowdel 8 . . . 19 10600446 10600446 C T 19:g.10600446C>T ENST00000171111.5:c.1409G>A 0.40 14 21 35 91 4/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H090285 Hepatocellular Adenoma R260Q OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 3 Somatic Unknown LGGM 19 10602799 10602799 C T 19:g.10602799C>T ENST00000171111.5:c.779G>A 0.65 15 8 90 3/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC2200T Hepatocellular Carcinoma R320W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.986 Missense_Mutation SNP 3 NA NA inserm.fr 19 10602620 10602620 G A 19:g.10602620G>A ENST00000171111.5:c.958C>T 93 3/6 Basal Cell Carcinoma (UNIGE, Nat Genet 2016) 5-GE005-T1 Skin Cancer, Non-Melanoma R601W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10597402 10597402 G A 19:g.10597402G>A ENST00000171111.5:c.1801C>T 0.26 33 94 105 6/6 0.00000397716 rs770453522 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) MEL-IPI_Pat100-Tumor-SM-53U2D Cutaneous Melanoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP 8 NA NA NA 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.18 17 79 551 4/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) LUAD-BS-12-R10269-Tumor-SM-9J2XO Lung Adenocarcinoma G417W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 2 NA NA NA 19 10602329 10602329 C A 19:g.10602329C>A ENST00000171111.5:c.1249G>T 0.90 18 2 343 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AJ-A3EK-01 Uterine Endometrioid Carcinoma R272C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.938 Missense_Mutation SNP diploid 2 . . . 19 10602764 10602764 G A 19:g.10602764G>A ENST00000171111.5:c.814C>T 0.38 21 35 21 5730 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AJ-A3EK-01 Uterine Endometrioid Carcinoma R601L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.917 Missense_Mutation SNP diploid 1 . . . 19 10597401 10597401 C A 19:g.10597401C>A ENST00000171111.5:c.1802G>T 0.34 24 47 31 5730 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7633-01 Lung Adenocarcinoma G333C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10602581 10602581 C A 19:g.10602581C>A ENST00000171111.5:c.997G>T 0.56 9 7 27 144 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7167-01 Lung Adenocarcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 3 . . . 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.82 0.01 40 9 1 76 103 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-MP-A4T7-01 Lung Adenocarcinoma G480W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 3 . . . 19 10600417 10600417 C A 19:g.10600417C>A ENST00000171111.5:c.1438G>T 0.28 11 29 48 123 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-4507-01 Lung Adenocarcinoma R470C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.242 Missense_Mutation SNP shallowdel 8 . . . 19 10600447 10600447 G A 19:g.10600447G>A ENST00000171111.5:c.1408C>T 0.39 21 33 59 183 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z043-01 Lung Adenocarcinoma R260L OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 3 . . . 19 10602799 10602799 C A 19:g.10602799C>A ENST00000171111.5:c.779G>T 0.38 8 13 16 177 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-4486-01 Lung Adenocarcinoma G333S OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10602581 10602581 C T 19:g.10602581C>T ENST00000171111.5:c.997G>A 0.57 16 12 29 143 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-86-8281-01 Lung Adenocarcinoma G333S OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10602581 10602581 C T 19:g.10602581C>T ENST00000171111.5:c.997G>A 0.36 14 25 25 226 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-4514-01 Lung Adenocarcinoma R470S OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.1;Polyphen-2: impact: possibly_damaging, score: 0.899 Missense_Mutation SNP shallowdel 8 . . . 19 10600447 10600447 G T 19:g.10600447G>T ENST00000171111.5:c.1408C>A 0.21 0.01 10 38 1 71 293 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-50-5051-01 Lung Adenocarcinoma G417R OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10602329 10602329 C T 19:g.10602329C>T ENST00000171111.5:c.1249G>A 0.50 7 7 17 102 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-67-3771-01 Lung Adenocarcinoma G417E OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 2 . . . 19 10602328 10602328 C T 19:g.10602328C>T ENST00000171111.5:c.1250G>A 0.54 13 11 53 951 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-75-7027-01 Lung Adenocarcinoma R320W OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.986 Missense_Mutation SNP shallowdel 3 . . . 19 10602620 10602620 G A 19:g.10602620G>A ENST00000171111.5:c.958C>T 0.60 27 18 66 212 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-53-A4EZ-01 Lung Adenocarcinoma G417V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP shallowdel 2 . . . 19 10602328 10602328 C A 19:g.10602328C>A ENST00000171111.5:c.1250G>T 0.44 8 10 24 451 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8302-01 Lung Adenocarcinoma G417V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP shallowdel 2 . . . 19 10602328 10602328 C A 19:g.10602328C>A ENST00000171111.5:c.1250G>T 0.32 12 25 45 615 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-6778-01 Lung Adenocarcinoma M110V OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP shallowdel 2 . . . 19 10610382 10610382 T C 19:g.10610382T>C ENST00000171111.5:c.328A>G 0.34 11 21 37 357 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8620-01 Lung Adenocarcinoma G417W OncoKB: Predicted Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP gain 2 . . . 19 10602329 10602329 C A 19:g.10602329C>A ENST00000171111.5:c.1249G>T 0.67 20 10 24 434 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-3917-01 Lung Adenocarcinoma G333D OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: yes;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10602580 10602580 C T 19:g.10602580C>T ENST00000171111.5:c.998G>A 0.48 13 14 49 199 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005380-T01-IM5 Lung Adenocarcinoma R415C OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.842 Missense_Mutation SNP diploid 1 NA NA NA 19 10602335 10602335 G A 19:g.10602335G>A ENST00000171111.5:c.1243C>T 0.13 56 388 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010947-T01-IM5 Lung Adenocarcinoma G379D OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602442 10602442 C T 19:g.10602442C>T ENST00000171111.5:c.1136G>A 0.32 246 524 13 3/6 rs1014914854 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001927-T01-IM3 Lung Adenocarcinoma G430C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602290 10602290 C A 19:g.10602290C>A ENST00000171111.5:c.1288G>T 0.05 21 392 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002153-T01-IM3 Lung Adenocarcinoma G430C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602290 10602290 C A 19:g.10602290C>A ENST00000171111.5:c.1288G>T 0.44 335 434 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009466-T01-IM5 Lung Adenocarcinoma G430C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602290 10602290 C A 19:g.10602290C>A ENST00000171111.5:c.1288G>T 0.19 143 599 9 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0089-R1 Lung Squamous Cell Carcinoma R415H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.985 Missense_Mutation SNP 1 NA NA NA 19 10602334 10602334 C T 19:g.10602334C>T ENST00000171111.5:c.1244G>A 0.06 27 450 474 3/6 0.00000449559 rs1379198956 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0089-R2 Lung Squamous Cell Carcinoma R415H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.985 Missense_Mutation SNP 1 NA NA NA 19 10602334 10602334 C T 19:g.10602334C>T ENST00000171111.5:c.1244G>A 0.07 23 329 461 3/6 0.00000449559 rs1379198956 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0089-Pre-ctDNA Lung Squamous Cell Carcinoma R415H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.985 Missense_Mutation SNP 1 NA NA NA 19 10602334 10602334 C T 19:g.10602334C>T ENST00000171111.5:c.1244G>A 20 3/6 0.00000449559 rs1379198956 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-K7-A5RG-01 Hepatocellular Carcinoma G379V OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10602442 10602442 C A 19:g.10602442C>A ENST00000171111.5:c.1136G>T 0.12 12 92 70 124 3/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC1737T Hepatocellular Carcinoma G379D OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP NA Valid inserm.fr 19 10602442 10602442 C T 19:g.10602442C>T ENST00000171111.5:c.1136G>A 5 3/6 rs1014914854 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-73-4676-01 Lung Adenocarcinoma R415C OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.842 Missense_Mutation SNP diploid 1 . . . 19 10602335 10602335 G A 19:g.10602335G>A ENST00000171111.5:c.1243C>T 0.47 8 9 15 85 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z001-01 Lung Adenocarcinoma R415H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.985 Missense_Mutation SNP 1 . . . 19 10602334 10602334 C T 19:g.10602334C>T ENST00000171111.5:c.1244G>A 0.58 11 8 8 201 3/6 0.00000449559 rs1379198956 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-62-8398-01 Lung Adenocarcinoma G430V OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10602289 10602289 C A 19:g.10602289C>A ENST00000171111.5:c.1289G>T 0.56 19 15 51 74 3/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-RS50 Lung Adenocarcinoma S243F OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.915 Missense_Mutation SNP diploid 1 NA NA NA 19 10602850 10602850 G A 19:g.10602850G>A ENST00000171111.5:c.728C>T 0.55 11 9 144 3/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-RS26 Lung Adenocarcinoma Q530* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599988 10599988 G A 19:g.10599988G>A ENST00000171111.5:c.1588C>T 0.15 4 22 227 5/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-RS07 Lung Adenocarcinoma E121* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel NA NA NA 19 10610349 10610349 C A 19:g.10610349C>A ENST00000171111.5:c.361G>T 0.13 3 21 180 2/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A193 Lung Adenocarcinoma Q74Hfs*77 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel NA NA NA 19 10610476 10610494 GTCACACAGCTGCTGGCTG - 19:g.10610476_10610494del ENST00000171111.5:c.216_234del 0.17 8 40 236 2/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s32 Lung Adenocarcinoma G186C OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP NA NA MSKCC 19 10610154 10610154 C A 19:g.10610154C>A ENST00000171111.5:c.556G>T 0.20 16 65 376 2/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s22 Lung Adenocarcinoma Q227* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP NA NA MSKCC 19 10602899 10602899 G A 19:g.10602899G>A ENST00000171111.5:c.679C>T 0.25 6 18 132 3/6 Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-LN-A4A2-01 Esophageal Squamous Cell Carcinoma G186S OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10610154 10610154 C T 19:g.10610154C>T ENST00000171111.5:c.556G>A 0.16 3 16 22 124 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009273-T01-IM5 Mixed Cervical Carcinoma R260* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 NA NA NA 19 10602800 10602800 G A 19:g.10602800G>A ENST00000171111.5:c.778C>T 0.07 55 740 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006895-T01-IM5 Lung Adenocarcinoma X511_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid NA NA NA 19 10600046 10600046 T C 19:g.10600046T>C ENST00000171111.5:c.1532-2A>G 0.17 126 637 37 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011132-T01-IM5 Non-Small Cell Lung Cancer E449* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 2 NA NA NA 19 10600510 10600510 C A 19:g.10600510C>A ENST00000171111.5:c.1345G>T 0.20 149 597 14 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002865-T01-IM3 Lung Squamous Cell Carcinoma D422N OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.637 Missense_Mutation SNP diploid 3 NA NA NA 19 10602314 10602314 C T 19:g.10602314C>T ENST00000171111.5:c.1264G>A 0.91 266 26 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011561-T01-IM5 Head and Neck Squamous Cell Carcinoma of Unknown Primary D422N OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.637 Missense_Mutation SNP diploid 3 NA NA NA 19 10602314 10602314 C T 19:g.10602314C>T ENST00000171111.5:c.1264G>A 0.06 57 878 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004891-T01-IM5 Lung Adenocarcinoma E444* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 NA NA NA 19 10600525 10600525 C A 19:g.10600525C>A ENST00000171111.5:c.1330G>T 0.33 121 241 11 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002421-T01-IM3 Lung Adenocarcinoma E441* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602257 10602257 C A 19:g.10602257C>A ENST00000171111.5:c.1321G>T 0.25 133 398 22 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009895-T01-IM5 Cancer of Unknown Primary E441* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602257 10602257 C A 19:g.10602257C>A ENST00000171111.5:c.1321G>T 0.83 241 49 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006172-T01-IM5 Lung Adenocarcinoma V420Sfs*38 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602320 10602320 C - 19:g.10602320del ENST00000171111.5:c.1258del 0.19 237 992 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009825-T01-IM5 Cholangiocarcinoma V420Sfs*38 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602320 10602320 C - 19:g.10602320del ENST00000171111.5:c.1258del 0.10 87 808 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004382-T01-IM5 Lung Adenocarcinoma K97* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610421 10610421 T A 19:g.10610421T>A ENST00000171111.5:c.289A>T 0.70 197 84 38 2/6 0.00000398108 rs1425671494 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000427-T01-IM3 Lung Adenocarcinoma E542Dfs*31 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599949 10599950 TC - 19:g.10599949_10599950del ENST00000171111.5:c.1626_1627del 0.31 247 554 11 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000989-T01-IM3 Lung Adenocarcinoma R336* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 NA NA NA 19 10602572 10602572 G A 19:g.10602572G>A ENST00000171111.5:c.1006C>T 0.21 51 194 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000825-T01-IM3 Lung Adenocarcinoma Q82* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610466 10610466 G A 19:g.10610466G>A ENST00000171111.5:c.244C>T 0.23 23 76 15 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004643-T01-IM5 Lung Adenocarcinoma A356Gfs*55 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602501 10602511 CTGCAGGTCCG - 19:g.10602501_10602511del ENST00000171111.5:c.1067_1077del 0.09 24 238 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004189-T01-IM5 Lung Adenocarcinoma G570* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599868 10599868 C A 19:g.10599868C>A ENST00000171111.5:c.1708G>T 0.28 175 449 60 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009419-T01-IM5 Lung Adenocarcinoma G570* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599868 10599868 C A 19:g.10599868C>A ENST00000171111.5:c.1708G>T 0.07 55 684 12 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001309-T01-IM3 Lung Adenocarcinoma M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602354 10602354 G - 19:g.10602354del ENST00000171111.5:c.1224del 0.58 322 234 14 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002054-T01-IM3 Lung Adenocarcinoma M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602354 10602354 G - 19:g.10602354del ENST00000171111.5:c.1224del 0.45 88 106 21 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007029-T01-IM5 Lung Adenocarcinoma M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602354 10602354 G - 19:g.10602354del ENST00000171111.5:c.1224del 0.24 264 843 14 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002163-T01-IM3 Lung Adenocarcinoma H424Qfs*15 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602290 10602306 CGCCGACGGCATAGATG - 19:g.10602290_10602306del ENST00000171111.5:c.1272_1288del 0.25 158 475 22 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004124-T01-IM5 Lung Adenocarcinoma D529Pfs*44 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599991 10599992 CC - 19:g.10599991_10599992del ENST00000171111.5:c.1584_1585del 0.08 58 633 10 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009638-T01-IM5 Lung Adenocarcinoma I500Mfs*3 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10600352 10600355 TGTG - 19:g.10600352_10600355del ENST00000171111.5:c.1500_1503del 0.11 129 1057 17 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009370-T01-IM5 Lung Adenocarcinoma W352* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602522 10602522 C T 19:g.10602522C>T ENST00000171111.5:c.1056G>A 0.07 39 508 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001163-T01-IM3 Lung Adenocarcinoma E258* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602806 10602806 C A 19:g.10602806C>A ENST00000171111.5:c.772G>T 0.20 100 391 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002677-T01-IM3 Lung Adenocarcinoma E258* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602806 10602806 C A 19:g.10602806C>A ENST00000171111.5:c.772G>T 0.53 57 50 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008161-T01-IM5 Lung Adenocarcinoma M550* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599929 10599929 G - 19:g.10599929del ENST00000171111.5:c.1647del 0.46 890 1047 5 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008161-T02-IM5 Lung Adenocarcinoma M550* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599929 10599929 G - 19:g.10599929del ENST00000171111.5:c.1647del 0.49 524 550 3 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007977-T01-IM5 Non-Small Cell Lung Cancer K323Rfs*5 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602612 10602612 G - 19:g.10602612del ENST00000171111.5:c.966del 0.19 65 285 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008404-T01-IM5 Lung Adenocarcinoma A331Kfs*14 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602570 10602587 TCGGAAGTAGCCGCCCGC CCTT 19:g.10602570_10602587delinsCCTT ENST00000171111.5:c.991_1008delinsAAGG 0.69 486 218 12 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001375-T01-IM3 Lung Adenocarcinoma S224Pfs*123 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602901 10602908 CAGTGGGA - 19:g.10602901_10602908del ENST00000171111.5:c.670_677del 0.08 20 235 12 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000459-T01-IM3 Lung Adenocarcinoma E535* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599973 10599973 C A 19:g.10599973C>A ENST00000171111.5:c.1603G>T 0.08 12 136 8 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003240-T01-IM5 Lung Adenocarcinoma R601* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10597401 10597402 CG A 19:g.10597401_10597402delinsA ENST00000171111.5:c.1801_1802delinsT 0.35 184 346 8 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001385-T01-IM3 Lung Adenocarcinoma G186C OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10610154 10610154 C A 19:g.10610154C>A ENST00000171111.5:c.556G>T 0.17 79 392 13 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004591-T01-IM5 Lung Adenocarcinoma G186C OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10610154 10610154 C A 19:g.10610154C>A ENST00000171111.5:c.556G>T 0.82 448 98 4 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000602-T01-IM3 Lung Adenocarcinoma E198* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610118 10610118 C A 19:g.10610118C>A ENST00000171111.5:c.592G>T 0.25 250 770 20 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000789-T01-IM3 Lung Adenocarcinoma F546Lfs*2 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599938 10599938 G - 19:g.10599938del ENST00000171111.5:c.1638del 0.43 218 289 18 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006713-T02-IM5 Lung Adenocarcinoma F478Lfs*22 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10600424 10600424 G - 19:g.10600424del ENST00000171111.5:c.1431del 0.10 73 645 4 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005316-T01-IM5 Lung Adenocarcinoma G186V OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10610153 10610153 C A 19:g.10610153C>A ENST00000171111.5:c.557G>T 0.59 373 263 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006993-T01-IM5 Lung Adenocarcinoma E192* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610136 10610136 C A 19:g.10610136C>A ENST00000171111.5:c.574G>T 0.11 57 450 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009196-T01-IM5 Lung Adenocarcinoma W591* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10597430 10597430 C T 19:g.10597430C>T ENST00000171111.5:c.1773G>A 0.09 86 921 11 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009762-T01-IM5 Lung Adenocarcinoma R296Afs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602692 10602692 G - 19:g.10602692del ENST00000171111.5:c.886del 0.21 180 658 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009017-T01-IM5 Lung Adenocarcinoma Q402* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602374 10602374 G A 19:g.10602374G>A ENST00000171111.5:c.1204C>T 0.37 417 713 34 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007665-T01-IM5 Lung Adenocarcinoma T43Sfs*35 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610581 10610583 CGT A 19:g.10610581_10610583delinsA ENST00000171111.5:c.127_129delinsT 0.09 11 116 1 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006954-T01-IM5 Lung Adenocarcinoma W403* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602370 10602370 C T 19:g.10602370C>T ENST00000171111.5:c.1208G>A 0.18 143 635 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007234-T01-IM5 Lung Adenocarcinoma R296Afs*9 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602620 10602692 GGCAGGGCATCACCTGCGTGGGCTTGTGCAGGGTGAGCTCCTCGAAGATCTTGACCAGGTAGTCCTTGCAGCG AGC 19:g.10602620_10602692delinsAGC ENST00000171111.5:c.886_958delinsGCT 0.66 609 312 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005871-T01-IM5 Lung Adenocarcinoma I566Tfs*28 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599876 10599879 TAGA - 19:g.10599876_10599879del ENST00000171111.5:c.1697_1700del 0.39 297 461 3 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004488-T01-IM5 Lung Adenocarcinoma R272Lfs*77 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602762 10602763 GC - 19:g.10602762_10602763del ENST00000171111.5:c.815_816del 0.32 144 311 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004615-T01-IM5 Lung Adenocarcinoma V152Pfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610255 10610256 AC - 19:g.10610255_10610256del ENST00000171111.5:c.454_455del 0.36 185 323 15 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002631-T01-IM3 Lung Adenocarcinoma X442_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid NA NA NA 19 10600530 10600530 C T 19:g.10600530C>T ENST00000171111.5:c.1326-1G>A 0.15 82 448 6 0.00000405134 rs1568397317 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002611-T01-IM3 Lung Adenocarcinoma K216* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602932 10602932 T A 19:g.10602932T>A ENST00000171111.5:c.646A>T 0.25 90 277 57 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001986-T01-IM3 Lung Adenocarcinoma E213* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610073 10610073 C A 19:g.10610073C>A ENST00000171111.5:c.637G>T 0.38 145 234 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008404-T02-IM5 Lung Adenocarcinoma G332Dfs*64 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602571 10602583 CGGAAGTAGCCGC - 19:g.10602571_10602583del ENST00000171111.5:c.995_1007del 0.45 200 243 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002635-T01-IM3 Lung Adenocarcinoma R413Vfs*45 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602341 10602341 G - 19:g.10602341del ENST00000171111.5:c.1237del 0.38 240 394 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007309-T01-IM5 Lung Adenocarcinoma G332Afs*68 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602583 10602583 C - 19:g.10602583del ENST00000171111.5:c.995del 0.47 168 186 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009856-T01-IM5 Lung Adenocarcinoma A95Pfs*62 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610427 10610427 C - 19:g.10610427del ENST00000171111.5:c.283del 0.44 534 673 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002444-T01-IM3 Lung Adenocarcinoma S338F OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation DNP diploid NA NA NA 19 10602564 10602565 CG AA 19:g.10602564_10602565delinsAA ENST00000171111.5:c.1013_1014delinsTT 0.34 166 324 15 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005975-T01-IM5 Lung Adenocarcinoma G433Afs*25 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602280 10602280 C - 19:g.10602280del ENST00000171111.5:c.1298del 0.16 97 496 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010024-T01-IM5 Lung Squamous Cell Carcinoma D422H OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP diploid 3 NA NA NA 19 10602314 10602314 C G 19:g.10602314C>G ENST00000171111.5:c.1264G>C 0.21 324 1203 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001351-T01-IM3 Breast Invasive Lobular Carcinoma Y491* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10600382 10600382 G T 19:g.10600382G>T ENST00000171111.5:c.1473C>A 0.21 53 196 19 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005790-T01-IM5 Breast Invasive Ductal Carcinoma X566_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site DEL diploid NA NA NA 19 10599846 10599878 TTCCCCGCCCCCAGGGCCTCACCAAGGACGTAG - 19:g.10599846_10599878del ENST00000171111.5:c.1698_1708+22del 0.32 137 290 10 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005790-T01-IM5 Breast Invasive Ductal Carcinoma N238Rfs*33 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602847 10602865 TCGGACTCGCAGCGCACGT - 19:g.10602847_10602865del ENST00000171111.5:c.713_731del 0.21 87 332 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005309-T01-IM5 Adenocarcinoma, NOS S21* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610648 10610648 G T 19:g.10610648G>T ENST00000171111.5:c.62C>A 0.20 94 373 26 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007114-T01-IM5 Lung Adenocarcinoma X511_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid NA NA NA 19 10600323 10600323 C A 19:g.10600323C>A ENST00000171111.5:c.1531+1G>T 0.20 172 672 9 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009756-T01-IM5 Cancer of Unknown Primary E307* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602659 10602659 C A 19:g.10602659C>A ENST00000171111.5:c.919G>T 0.49 465 490 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010088-T01-IM5 Oropharynx Squamous Cell Carcinoma X214_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid NA NA NA 19 10602939 10602939 C T 19:g.10602939C>T ENST00000171111.5:c.640-1G>A 0.20 155 615 13 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010571-T01-IM5 Large Cell Neuroendocrine Carcinoma V547Rfs*27 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10599938 10599939 - A 19:g.10599938_10599939insA ENST00000171111.5:c.1637dup 0.39 411 653 13 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002340-T01-IM3 Lung Adenocarcinoma M147_E149delinsIG* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation ONP diploid NA NA NA 19 10610265 10610269 CGCCC AGCCA 19:g.10610265_10610269delinsAGCCA ENST00000171111.5:c.441_445delinsTGGCT 0.30 170 393 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003276-T01-IM5 Lung Adenocarcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site DNP diploid NA NA NA 19 10599867 10599868 CC AA 19:g.10599867_10599868delinsAA ENST00000171111.5:c.1708_1708+1delinsTT 0.44 325 406 6 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009083-T01-IM5 Lung Adenocarcinoma C518_Y520delinsGV* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation ONP diploid NA NA NA 19 10600016 10600024 ATAGATACA CTAGACACC 19:g.10600016_10600024delinsCTAGACACC ENST00000171111.5:c.1552_1560delinsGGTGTCTAG 0.12 101 761 21 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010789-T01-IM5 Gallbladder Cancer Y567* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599875 10599875 G T 19:g.10599875G>T ENST00000171111.5:c.1701C>A 0.06 66 1093 2 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000426-T01-IM3 Lung Adenocarcinoma E496* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10600369 10600369 C A 19:g.10600369C>A ENST00000171111.5:c.1486G>T 0.25 223 663 7 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000729-T01-IM3 Lung Squamous Cell Carcinoma I137Mfs*33 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610287 10610299 GTAGGCGAATTCA CC 19:g.10610287_10610299delinsCC ENST00000171111.5:c.411_423delinsGG 0.11 69 565 10 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001035-T01-IM3 Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma Q530* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599988 10599988 G A 19:g.10599988G>A ENST00000171111.5:c.1588C>T 0.18 144 652 55 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001574-T01-IM3 Cancer of Unknown Primary V167Lfs*63 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610211 10610211 C - 19:g.10610211del ENST00000171111.5:c.499del 0.43 434 575 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001628-T01-IM3 Cancer of Unknown Primary S391Afs*9 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602408 10602408 G - 19:g.10602408del ENST00000171111.5:c.1170del 0.30 124 292 28 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001741-T02-IM3 Cancer of Unknown Primary D422Y OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP diploid 3 NA NA NA 19 10602314 10602314 C A 19:g.10602314C>A ENST00000171111.5:c.1264G>T 0.74 391 135 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001741-T01-IM3 Cancer of Unknown Primary D422Y OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP diploid 3 NA NA NA 19 10602314 10602314 C A 19:g.10602314C>A ENST00000171111.5:c.1264G>T 0.47 127 145 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001853-T01-IM3 Hurthle Cell Thyroid Cancer L291Cfs*26 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602707 10602707 G - 19:g.10602707del ENST00000171111.5:c.871del 0.56 74 59 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002272-T01-IM3 Uterine Leiomyosarcoma D589Rfs*30 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10597438 10597439 - T 19:g.10597438_10597439insT ENST00000171111.5:c.1764dup 0.07 43 568 1 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003311-T01-IM5 Lung Adenocarcinoma E57* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610541 10610541 C A 19:g.10610541C>A ENST00000171111.5:c.169G>T 0.15 61 338 40 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003734-T01-IM5 Lung Adenocarcinoma R565* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10599883 10599884 - A 19:g.10599883_10599884insA ENST00000171111.5:c.1692_1693insT 0.07 42 592 20 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004281-T01-IM5 Papillary Renal Cell Carcinoma K108Rfs*49 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610387 10610387 T - 19:g.10610387del ENST00000171111.5:c.323del 0.23 136 465 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004708-T01-IM5 Pleural Mesothelioma, Epithelioid Type Y396* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation INS diploid NA NA NA 19 10602390 10602391 - T 19:g.10602390_10602391insT ENST00000171111.5:c.1187dup 0.13 87 578 1 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009491-T01-IM5 Cancer of Unknown Primary Y396* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation INS diploid NA NA NA 19 10602390 10602391 - T 19:g.10602390_10602391insT ENST00000171111.5:c.1187dup 0.23 220 739 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005530-T02-IM5 Cancer of Unknown Primary E134Rfs*5 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10610310 10610311 - T 19:g.10610310_10610311insT ENST00000171111.5:c.399_400insA 0.36 498 878 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007067-T01-IM5 Lung Adenocarcinoma E69* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610505 10610505 C A 19:g.10610505C>A ENST00000171111.5:c.205G>T 0.32 417 901 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007595-T01-IM5 Unclassified Renal Cell Carcinoma Y584* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation INS diploid 1 NA NA NA 19 10597451 10597452 - T 19:g.10597451_10597452insT ENST00000171111.5:c.1751dup 0.27 368 1005 4 6/6 0.0000039794 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007695-T01-IM5 Cancer of Unknown Primary X511_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site DEL diploid NA NA NA 19 10600043 10600050 GCCTAAAG - 19:g.10600043_10600050del ENST00000171111.5:c.1532-6_1533del 0.06 28 462 4 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008032-T01-IM5 Lung Adenosquamous Carcinoma V420Gfs*25 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10602324 10602325 - A 19:g.10602324_10602325insA ENST00000171111.5:c.1253dup 0.49 239 244 21 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009194-T01-IM5 Lung Adenocarcinoma E542* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10599952 10599952 C A 19:g.10599952C>A ENST00000171111.5:c.1624G>T 0.28 213 542 6 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009214-T01-IM5 Lung Adenocarcinoma G333Lfs*16 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602581 10602582 CG - 19:g.10602581_10602582del ENST00000171111.5:c.996_997del 0.13 109 706 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009268-T01-IM5 Pancreatic Adenocarcinoma E121* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610349 10610349 C A 19:g.10610349C>A ENST00000171111.5:c.361G>T 0.11 137 1128 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009642-T01-IM5 Poorly Differentiated Carcinoma, NOS Y396* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10602390 10602390 G C 19:g.10602390G>C ENST00000171111.5:c.1188C>G 0.07 125 1622 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009684-T01-IM5 Lung Adenocarcinoma X511_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid NA NA NA 19 10600045 10600045 C A 19:g.10600045C>A ENST00000171111.5:c.1532-1G>T 0.54 363 304 23 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010332-T01-IM5 Lung Adenocarcinoma G186F OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation DNP diploid NA NA NA 19 10610153 10610154 CC AA 19:g.10610153_10610154delinsAA ENST00000171111.5:c.556_557delinsTT 0.12 93 660 33 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011005-T01-IM5 Lung Adenocarcinoma M550Ifs*24 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid NA NA NA 19 10599926 10599927 - T 19:g.10599926_10599927insT ENST00000171111.5:c.1649_1650insA 0.19 185 791 10 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011242-T01-IM5 Lung Adenocarcinoma E446* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10600519 10600519 C A 19:g.10600519C>A ENST00000171111.5:c.1336G>T 0.14 114 717 7 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011298-T01-IM5 Lung Adenocarcinoma E138* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610298 10610298 C A 19:g.10610298C>A ENST00000171111.5:c.412G>T 0.13 115 764 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011342-T01-IM5 Lung Adenocarcinoma R596* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10597417 10597417 G A 19:g.10597417G>A ENST00000171111.5:c.1786C>T 0.10 83 745 7 6/6 0.00000397741 rs1415900791 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011331-T01-IM5 Lung Adenocarcinoma R296Qfs*52 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10602687 10602691 GCAGC - 19:g.10602687_10602691del ENST00000171111.5:c.887_891del 0.59 344 241 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012064-T01-IM5 Lung Adenocarcinoma E117* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid NA NA NA 19 10610361 10610361 C A 19:g.10610361C>A ENST00000171111.5:c.349G>T 0.27 195 535 14 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012063-T01-IM5 Lung Adenocarcinoma F546* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation DNP diploid NA NA NA 19 10599938 10599939 GA TT 19:g.10599938_10599939delinsTT ENST00000171111.5:c.1637_1638delinsAA 0.11 105 866 13 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012310-T01-IM5 Mucinous Ovarian Cancer L56Wfs*12 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10610544 10610544 G - 19:g.10610544del ENST00000171111.5:c.166del 0.33 172 348 6 2/6 Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccRCC_15 Renal Clear Cell Carcinoma with Sarcomatoid Features E444* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA NA UTokyo 19 10600525 10600525 C A 19:g.10600525C>A ENST00000171111.5:c.1330G>T 73 4/6 Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccRCC_34 Renal Clear Cell Carcinoma with Sarcomatoid Features Y584* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL 1 NA NA UTokyo 19 10597451 10597451 G - 19:g.10597451del ENST00000171111.5:c.1752del 102 6/6 Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-P4-A5EB-01 Papillary Renal Cell Carcinoma Q178* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel 1 . . . 19 10610178 10610178 G A 19:g.10610178G>A ENST00000171111.5:c.532C>T 0.89 0.0079 86 11 1 125 132 2/6 rs1568401513 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-NYU739 Lung Adenocarcinoma T588Yfs*31 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid 1 Unknown NA broad.mit.edu 19 10597441 10597442 - A 19:g.10597441_10597442insA ENST00000171111.5:c.1761dup 71 6/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01769 Lung Adenocarcinoma T314Rfs*3 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid 1 Unknown NA broad.mit.edu 19 10602639 10602639 G - 19:g.10602639del ENST00000171111.5:c.939del 287 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01774 Lung Adenocarcinoma X511_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid Unknown NA broad.mit.edu 19 10600046 10600046 T C 19:g.10600046T>C ENST00000171111.5:c.1532-2A>G 349 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-NYU284 Lung Adenocarcinoma Q284* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 Unknown NA broad.mit.edu 19 10602728 10602728 G A 19:g.10602728G>A ENST00000171111.5:c.850C>T 685 3/6 Metastatic Breast Cancer (INSERM, PLoS Med 2016) MBC_94 Invasive Breast Carcinoma S338L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel Somatic NA GR 19 10602565 10602565 G A 19:g.10602565G>A ENST00000171111.5:c.1013C>T 0.28 22 58 57 40 3/6 Skin Cutaneous Melanoma (Broad, Cell 2012) MEL-Ma-Mel-59 Cutaneous Melanoma V302Gfs*48 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS 1 NA NA broad.mit.edu 19 10602673 10602674 - C 19:g.10602673_10602674insC ENST00000171111.5:c.904dup 120 3/6 SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018) 115 Lung Adenocarcinoma I566Tfs*28 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid NA NA NA 19 10599876 10599879 TAGA - 19:g.10599876_10599879del ENST00000171111.5:c.1697_1700del 0.39 297 461 3 5/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-4532-01 Lung Squamous Cell Carcinoma N469Kfs*11 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS shallowdel . . . 19 10600448 10600449 - T 19:g.10600448_10600449insT ENST00000171111.5:c.1406dup 0.51 56 54 107 339 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-37-4133-01 Lung Squamous Cell Carcinoma S243C OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.977 Missense_Mutation SNP shallowdel 1 . . . 19 10602850 10602850 G C 19:g.10602850G>C ENST00000171111.5:c.728C>G 0.66 47 24 130 244 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-39-5036-01 Lung Squamous Cell Carcinoma G423V OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.816 Missense_Mutation SNP shallowdel 1 . . . 19 10602310 10602310 C A 19:g.10602310C>A ENST00000171111.5:c.1268G>T 0.50 9 9 38 244 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-46-6025-01 Lung Squamous Cell Carcinoma Q75* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel 1 . . . 19 10610487 10610487 G A 19:g.10610487G>A ENST00000171111.5:c.223C>T 0.54 39 33 125 179 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-AASJ-01 Lung Squamous Cell Carcinoma G186S OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP gain . . . 19 10610154 10610154 C T 19:g.10610154C>T ENST00000171111.5:c.556G>A 0.11 4 32 15 169 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-94-7557-01 Lung Squamous Cell Carcinoma S338L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel . . . 19 10602565 10602565 G A 19:g.10602565G>A ENST00000171111.5:c.1013C>T 0.43 6 8 29 82 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-22-4594-01 Lung Squamous Cell Carcinoma P318Rfs*10 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10602624 10602625 GG C 19:g.10602624_10602625delinsC ENST00000171111.5:c.953_954delinsG 0.37 40 67 88 319 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0031-R1 Non-Small Cell Lung Cancer E593* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA NA NA 19 10597426 10597426 C A 19:g.10597426C>A ENST00000171111.5:c.1777G>T 0.60 360 239 457 6/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0031-R2 Non-Small Cell Lung Cancer E593* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA NA NA 19 10597426 10597426 C A 19:g.10597426C>A ENST00000171111.5:c.1777G>T 0.48 328 353 465 6/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0031-R3 Non-Small Cell Lung Cancer E593* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA NA NA 19 10597426 10597426 C A 19:g.10597426C>A ENST00000171111.5:c.1777G>T 0.47 262 293 447 6/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0031-Pre-ctDNA Non-Small Cell Lung Cancer E593* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA NA NA 19 10597426 10597426 C A 19:g.10597426C>A ENST00000171111.5:c.1777G>T 17 6/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0036-R1 Non-Small Cell Lung Cancer L281Rfs*36 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602736 10602736 A - 19:g.10602736del ENST00000171111.5:c.842del 0.06 25 408 95 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0036-R2 Non-Small Cell Lung Cancer L281Rfs*36 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602736 10602736 A - 19:g.10602736del ENST00000171111.5:c.842del 0.25 105 315 98 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0036-R3 Non-Small Cell Lung Cancer L281Rfs*36 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602736 10602736 A - 19:g.10602736del ENST00000171111.5:c.842del 0.20 59 241 99 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0036-R4 Non-Small Cell Lung Cancer L281Rfs*36 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602736 10602736 A - 19:g.10602736del ENST00000171111.5:c.842del 0.09 36 367 96 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R1 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.13 43 286 195 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-LN1 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.09 16 172 208 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R2 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.06 9 147 200 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R3 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.18 15 68 207 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R4 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.08 12 134 202 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R5 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.06 13 218 202 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R6 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.15 33 181 212 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0099-R7 Lung Adenosquamous Carcinoma M209Sfs*21 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10610084 10610084 A - 19:g.10610084del ENST00000171111.5:c.626del 0.15 30 168 204 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0046-R1 Non-Small Cell Lung Cancer M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602353 10602353 T - 19:g.10602353del ENST00000171111.5:c.1225del 0.36 124 216 119 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0046-R2 Non-Small Cell Lung Cancer M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602353 10602353 T - 19:g.10602353del ENST00000171111.5:c.1225del 0.20 95 373 113 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0046-R3 Non-Small Cell Lung Cancer M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602353 10602353 T - 19:g.10602353del ENST00000171111.5:c.1225del 0.34 146 288 117 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0046-R4 Non-Small Cell Lung Cancer M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA NA 19 10602353 10602353 T - 19:g.10602353del ENST00000171111.5:c.1225del 0.32 136 290 120 3/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-DK-A1A3-01 Bladder Urothelial Carcinoma Y537Afs*12 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS gain . . . 19 10599968 10599969 - CA 19:g.10599968_10599969insCA ENST00000171111.5:c.1607_1608insTG 0.26 9 25 54 566 5/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-CU-A0YR-01 Bladder Urothelial Carcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid . . . 19 10597496 10597496 T C 19:g.10597496T>C ENST00000171111.5:c.1709-2A>G 0.44 34 43 97 140 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-BC-A8YO-01 Hepatocellular Carcinoma G186S OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10610154 10610154 C T 19:g.10610154C>T ENST00000171111.5:c.556G>A 0.74 28 10 52 65 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AACQ-01 Hepatocellular Carcinoma K97* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel . . . 19 10610421 10610421 T A 19:g.10610421T>A ENST00000171111.5:c.289A>T 0.75 33 11 84 206 2/6 0.00000398108 rs1425671494 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-2Y-A9GS-01 Hepatocellular Carcinoma L355Sfs*37 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10602490 10602514 CTCCGCGGCACCTGCAGGTCCGCCA - 19:g.10602490_10602514del ENST00000171111.5:c.1064_1088del 0.56 39 31 98 65 3/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AACB-01 Hepatocellular Carcinoma G127Vfs*30 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid . . . 19 10610330 10610330 C - 19:g.10610330del ENST00000171111.5:c.380del 0.38 39 64 74 84 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AACO-01 Hepatocellular Carcinoma I519Mfs*12 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel 1 . . . 19 10600016 10600019 ATAG - 19:g.10600016_10600019del ENST00000171111.5:c.1557_1560del 0.58 36 26 120 42 5/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-G3-A3CK-01 Hepatocellular Carcinoma D256Vfs*95 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid . . . 19 10602811 10602812 - CGTA 19:g.10602811_10602812insCGTA ENST00000171111.5:c.763_766dup 0.23 19 65 70 207 3/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-FR-A726-01 Cutaneous Melanoma S243F OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.915 Missense_Mutation SNP 1 . . . 19 10602850 10602850 G A 19:g.10602850G>A ENST00000171111.5:c.728C>T 0.23 24 81 75 5858 3/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-UF-A7JF-01 Head and Neck Squamous Cell Carcinoma E134* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid . . . 19 10610310 10610310 C A 19:g.10610310C>A ENST00000171111.5:c.400G>T 0.22 12 42 61 89 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-BB-7870-01 Head and Neck Squamous Cell Carcinoma C23Y OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.17;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid 1 . . . 19 10610642 10610642 C T 19:g.10610642C>T ENST00000171111.5:c.68G>A 0.41 83 117 72 257 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CV-A6JU-01 Head and Neck Squamous Cell Carcinoma E126* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid . . . 19 10610334 10610335 - A 19:g.10610334_10610335insA ENST00000171111.5:c.375dup 0.17 14 68 48 119 2/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H112501 Hepatocellular Adenoma R260* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 Somatic Unknown LGGM 19 10602800 10602800 G A 19:g.10602800G>A ENST00000171111.5:c.778C>T 0.21 5 19 1025 3/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H112501 Hepatocellular Adenoma R507* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid Somatic Unknown LGGM 19 10600336 10600336 G A 19:g.10600336G>A ENST00000171111.5:c.1519C>T 0.29 8 20 1025 4/6 0.000011930421778664796 rs751088754 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC1592T Hepatocellular Carcinoma E542Dfs*31 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA Valid inserm.fr 19 10599949 10599950 TC - 19:g.10599949_10599950del ENST00000171111.5:c.1626_1627del 65 5/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC301T Hepatocellular Carcinoma E593* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 NA Valid inserm.fr 19 10597426 10597426 C A 19:g.10597426C>A ENST00000171111.5:c.1777G>T 90 6/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC1152T Hepatocellular Carcinoma X442_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP NA Valid inserm.fr 19 10600531 10600531 T A 19:g.10600531T>A ENST00000171111.5:c.1326-2A>T 49 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC798T Hepatocellular Carcinoma Y396Sfs*19 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS NA Valid inserm.fr 19 10602391 10602392 - G 19:g.10602391_10602392insG ENST00000171111.5:c.1186_1187insC 178 3/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) BCM617T Hepatocellular Carcinoma T330Rfs*19 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA inserm.fr 19 10602589 10602590 GT - 19:g.10602589_10602590del ENST00000171111.5:c.988_989del 71 3/6 Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014) CSCC-38-T Cutaneous Squamous Cell Carcinoma R269Gfs*8 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL Somatic Untested hgsc.bcm.edu 19 10602773 10602773 G - 19:g.10602773del ENST00000171111.5:c.805del 0.22 19 66 83 1631 3/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) KA3947 Lung Adenocarcinoma L374* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP NA NA NA 19 10602457 10602457 A T 19:g.10602457A>T ENST00000171111.5:c.1121T>A 0.58 7 5 312 3/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) SU2C_Lung-SU2C-DFCI-LUAD-1013-Tumor-SM-AOL7V Lung Adenocarcinoma R459* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP NA NA NA 19 10600480 10600480 G A 19:g.10600480G>A ENST00000171111.5:c.1375C>T 0.14 36 226 110 4/6 0.0000039841 rs755536041 Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015_S01524 Small Cell Lung Cancer K323Rfs*5 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA ucologne 19 10602610 10602610 T - 19:g.10602610del ENST00000171111.5:c.968del 0.50 23 23 103 3/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1146 Cutaneous Melanoma Y85Lfs*41 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA University of Michigan 19 10610454 10610456 GGT GG 19:g.10610454_10610456delinsGG ENST00000171111.5:c.254del 0.29 228 552 666 2209 Metastatic Solid Cancers (UMich, Nature 2017) MO_1236 Lung Adenocarcinoma E37* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP NA NA University of Michigan 19 10610601 10610601 C A 19:g.10610601C>A ENST00000171111.5:c.109G>T 0.47 0.0037 157 175 1 267 228 2/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1315 Lung Squamous Cell Carcinoma L471Sfs*9 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS NA NA University of Michigan 19 10600442 10600445 GAGA GAGAC 19:g.10600442_10600445delinsGAGAC ENST00000171111.5:c.1409dup 0.44 71 92 139 39 Metastatic Solid Cancers (UMich, Nature 2017) MO_1433 Lung Adenocarcinoma M409* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL NA NA University of Michigan 19 10602354 10602354 G TG 19:g.10602354delinsTG ENST00000171111.5:c.1225dup 0.42 70 98 148 676 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AP-A0LM-01 Uterine Endometrioid Carcinoma D422N OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.637 Missense_Mutation SNP diploid 3 . . . 19 10602314 10602314 C T 19:g.10602314C>T ENST00000171111.5:c.1264G>A 0.37 10 17 15 13187 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-BS-A0TE-01 Uterine Endometrioid Carcinoma I519Yfs*8 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid 1 . . . 19 10600021 10600022 - A 19:g.10600021_10600022insA ENST00000171111.5:c.1554dup 0.63 37 22 22 301 5/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-A5-A1OF-01 Uterine Mixed Endometrial Carcinoma S338L OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid . . . 19 10602565 10602565 G A 19:g.10602565G>A ENST00000171111.5:c.1013C>T 0.24 10 32 33 10493 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-A5-A1OF-01 Uterine Mixed Endometrial Carcinoma W450* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid . . . 19 10600505 10600505 C T 19:g.10600505C>T ENST00000171111.5:c.1350G>A 0.22 6 21 20 10493 4/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AX-A2HC-01 Uterine Endometrioid Carcinoma R554* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid . . . 19 10599916 10599916 G A 19:g.10599916G>A ENST00000171111.5:c.1660C>T 0.43 25 33 62 12976 5/6 rs946921406 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-EO-A22U-01 Uterine Endometrioid Carcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP diploid . . . 19 10597496 10597496 T G 19:g.10597496T>G ENST00000171111.5:c.1709-2A>C 0.42 34 46 32 13829 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-35-3615-01 Lung Adenocarcinoma E449* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 2 . . . 19 10600510 10600510 C A 19:g.10600510C>A ENST00000171111.5:c.1345G>T 0.58 19 14 50 104 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-50-5936-01 Lung Adenocarcinoma Q46* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel 1 . . . 19 10610574 10610574 G A 19:g.10610574G>A ENST00000171111.5:c.136C>T 0.30 24 55 113 106 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-6972-01 Lung Adenocarcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP shallowdel . . . 19 10599866 10599866 A T 19:g.10599866A>T ENST00000171111.5:c.1708+2T>A 0.74 14 5 37 264 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7156-01 Lung Adenocarcinoma G477Afs*23 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10600425 10600425 C - 19:g.10600425del ENST00000171111.5:c.1430del 0.43 49 64 124 310 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-50-5068-01 Lung Adenocarcinoma G423V OncoKB: Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.816 Missense_Mutation SNP diploid 1 . . . 19 10602310 10602310 C A 19:g.10602310C>A ENST00000171111.5:c.1268G>T 0.16 4 21 21 85 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-35-5375-01 Lung Adenocarcinoma E593Rfs*2 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel 1 . . . 19 10597426 10597426 C - 19:g.10597426del ENST00000171111.5:c.1777del 0.47 57 64 84 387 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-7667-01 Lung Adenocarcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP shallowdel . . . 19 10597495 10597495 C A 19:g.10597495C>A ENST00000171111.5:c.1709-1G>T 0.60 27 18 79 431 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-A47F-01 Lung Adenocarcinoma L175Wfs*55 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel 1 . . . 19 10610187 10610187 G - 19:g.10610187del ENST00000171111.5:c.523del 0.29 22 54 44 78 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-A4SS-01 Lung Adenocarcinoma C613Afs*59 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10597367 10597367 G - 19:g.10597367del ENST00000171111.5:c.1836del 0.13 21 147 188 443 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8505-01 Lung Adenocarcinoma Q193* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel . . . 19 10610133 10610133 G A 19:g.10610133G>A ENST00000171111.5:c.577C>T 0.30 11 26 40 28 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-A492-01 Lung Adenocarcinoma E441* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel . . . 19 10602257 10602257 C A 19:g.10602257C>A ENST00000171111.5:c.1321G>T 0.54 13 11 36 262 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-A4DF-01 Lung Adenocarcinoma X570_splice OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Splice_Site SNP shallowdel . . . 19 10599867 10599867 C A 19:g.10599867C>A ENST00000171111.5:c.1708+1G>T 0.48 22 24 42 678 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-62-A470-01 Lung Adenocarcinoma R459Pfs*39 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10600473 10600479 ATCCTTC - 19:g.10600473_10600479del ENST00000171111.5:c.1376_1382del 0.46 18 21 57 105 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-69-8253-01 Lung Adenocarcinoma E41* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel . . . 19 10610589 10610589 C A 19:g.10610589C>A ENST00000171111.5:c.121G>T 0.33 33 66 154 133 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-73-4677-01 Lung Adenocarcinoma K287* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel 1 . . . 19 10602719 10602719 T A 19:g.10602719T>A ENST00000171111.5:c.859A>T 0.45 29 36 73 224 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7146-01 Lung Adenocarcinoma P492Qfs*8 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10600380 10600380 G - 19:g.10600380del ENST00000171111.5:c.1475del 0.34 29 57 73 348 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-97-8179-01 Lung Adenocarcinoma Q201* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid . . . 19 10610109 10610109 G A 19:g.10610109G>A ENST00000171111.5:c.601C>T 0.50 18 18 29 151 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-J2-8194-01 Lung Adenocarcinoma E540Rfs*32 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid . . . 19 10599954 10599958 GTTTC - 19:g.10599954_10599958del ENST00000171111.5:c.1618_1622del 0.30 13 31 48 141 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-MP-A4TE-01 Lung Adenocarcinoma V604Wfs*68 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL diploid . . . 19 10597393 10597393 C - 19:g.10597393del ENST00000171111.5:c.1810del 0.43 118 154 152 124 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-MP-A5C7-01 Lung Adenocarcinoma Y345* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP shallowdel . . . 19 10602543 10602543 G C 19:g.10602543G>C ENST00000171111.5:c.1035C>G 0.79 11 3 33 58 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z036-01 Lung Adenocarcinoma I500Tfs*4 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL . . . 19 10600356 10600356 A - 19:g.10600356del ENST00000171111.5:c.1499del 0.40 6 9 32 70 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-6970-01 Lung Adenocarcinoma K323* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid . . . 19 10602612 10602612 G AA 19:g.10602612delinsAA ENST00000171111.5:c.966delinsTT 0.35 19 36 52 175 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-86-8672-01 Lung Adenocarcinoma V123Rfs*31 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10610334 10610343 CAATGGACAC - 19:g.10610334_10610343del ENST00000171111.5:c.367_376del 0.27 13 35 116 263 2/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-BR-7851-01 Intestinal Type Stomach Adenocarcinoma Q20* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 1 . . . 19 10610652 10610652 G A 19:g.10610652G>A ENST00000171111.5:c.58C>T 0.08 3 36 49 1309 2/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CD-8536-01 Stomach Adenocarcinoma C249Y OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.768 Missense_Mutation SNP diploid 1 . . . 19 10602832 10602832 C T 19:g.10602832C>T ENST00000171111.5:c.746G>A 0.31 28 61 101 838 3/6 rs865938977 Breast Invasive Carcinoma (TCGA, PanCancer Atlas) TCGA-EW-A1J5-01 Breast Invasive Lobular Carcinoma E449* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP diploid 2 . . . 19 10600510 10600510 C A 19:g.10600510C>A ENST00000171111.5:c.1345G>T 0.13 4 27 32 364 4/6 Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-EK-A2RM-01 Cervical Squamous Cell Carcinoma S592* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Del DEL shallowdel . . . 19 10597423 10597429 CCTCGCT - 19:g.10597423_10597429del ENST00000171111.5:c.1774_1780del 0.54 26 22 63 81 6/6 Ampullary Carcinoma (Baylor College of Medicine, Cell Reports 2016) AMPAC_2713 Ampullary Carcinoma R336* OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Nonsense_Mutation SNP 1 Somatic Valid Baylor College of Medicine 19 10602572 10602572 G A 19:g.10602572G>A ENST00000171111.5:c.1006C>T 0.11 10 79 67 1847 3/6 Acute Myeloid Leukemia (TCGA, PanCancer Atlas) TCGA-AB-2854-03 Acute Myeloid Leukemia F478Lfs*2 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Frame_Shift_Ins INS diploid . . . 19 10600424 10600425 - C 19:g.10600424_10600425insC ENST00000171111.5:c.1430dup 0.14 11 69 50 305 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006730-T01-IM5 Colon Adenocarcinoma ZNF599-KEAP1 fusion OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION diploid MSKCC-DMP NA -1 6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008787-T01-IM5 Mixed Ovarian Carcinoma DNAH1-KEAP1 fusion OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION diploid MSKCC-DMP NA -1 6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-5B-A90C-01 Uterine Endometrioid Carcinoma KEAP1-AP1M2 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION diploid WashU NA -1 47 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-A5-A2K4-01 Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma THRAP3-KEAP1 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION diploid WashU NA -1 30 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CD-5800-01 Papillary Stomach Adenocarcinoma TYK2-KEAP1 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION amp WashU NA -1 147 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AARE-01 Lung Adenocarcinoma KEAP1-EYA2 OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion FUSION shallowdel WashU NA -1 1197 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009714-T01-IM5 Lung Adenocarcinoma KEAP1-intragenic OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion INTRAGENIC diploid MSKCC-DMP NA -1 20 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012151-T01-IM5 Lung Adenocarcinoma KEAP1-intragenic OncoKB: Likely Oncogenic, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA fusion INTRAGENIC diploid MSKCC-DMP NA -1 2 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A508 Lung Adenocarcinoma G364V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 2 NA NA NA 19 10602487 10602487 C A 19:g.10602487C>A ENST00000171111.5:c.1091G>T 0.10 5 47 7 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s48 Lung Adenocarcinoma E488K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 1 NA NA MSKCC 19 10600393 10600393 C T 19:g.10600393C>T ENST00000171111.5:c.1462G>A 0.27 45 119 120 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006304-T01-IM5 Glioblastoma Multiforme D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 0.11 110 922 7 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003347-T01-IM5 Lung Squamous Cell Carcinoma E488K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10600393 10600393 C T 19:g.10600393C>T ENST00000171111.5:c.1462G>A 0.60 372 251 15 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005080-T01-IM5 Lung Adenocarcinoma E488K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10600393 10600393 C T 19:g.10600393C>T ENST00000171111.5:c.1462G>A 0.59 685 485 41 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004659-T01-IM5 Lung Adenocarcinoma G364C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10602488 10602488 C A 19:g.10602488C>A ENST00000171111.5:c.1090G>T 0.30 75 173 9 3/6 rs1397945617 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005252-T01-IM5 Lung Adenocarcinoma G364C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10602488 10602488 C A 19:g.10602488C>A ENST00000171111.5:c.1090G>T 0.62 43 26 13 3/6 rs1397945617 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006878-T01-IM5 Lung Adenocarcinoma G364C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10602488 10602488 C A 19:g.10602488C>A ENST00000171111.5:c.1090G>T 0.20 179 737 5 3/6 rs1397945617 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005024-T01-IM5 Lung Adenocarcinoma V167F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 1 NA NA NA 19 10610211 10610211 C A 19:g.10610211C>A ENST00000171111.5:c.499G>T 0.49 776 797 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006714-T01-IM5 Bladder Urothelial Carcinoma M550I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10599926 10599926 C T 19:g.10599926C>T ENST00000171111.5:c.1650G>A 0.12 132 958 62 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001130-T01-IM3 Lung Adenocarcinoma D165N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.53;Polyphen-2: impact: benign, score: 0.089 Missense_Mutation SNP diploid 2 NA NA NA 19 10610217 10610217 C T 19:g.10610217C>T ENST00000171111.5:c.493G>A 0.35 362 679 9 2/6 0.00000398791 rs752325770 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004030-T01-IM5 Lung Adenocarcinoma I461M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.98 Missense_Mutation SNP diploid 1 NA NA NA 19 10600472 10600472 G C 19:g.10600472G>C ENST00000171111.5:c.1383C>G 0.30 122 278 25 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003523-T01-IM5 Lung Adenocarcinoma G509E OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10600329 10600329 C T 19:g.10600329C>T ENST00000171111.5:c.1526G>A 0.68 151 70 8 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003119-T01-IM5 Lung Adenocarcinoma E488V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 1 NA NA NA 19 10600392 10600392 T A 19:g.10600392T>A ENST00000171111.5:c.1463A>T 0.20 175 722 13 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005170-T01-IM5 Lung Adenocarcinoma I461F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.946 Missense_Mutation SNP diploid 1 NA NA NA 19 10600474 10600474 T A 19:g.10600474T>A ENST00000171111.5:c.1381A>T 0.28 185 481 4 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004658-T01-IM5 Lung Adenocarcinoma D479Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10600420 10600420 C A 19:g.10600420C>A ENST00000171111.5:c.1435G>T 0.13 52 337 13 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006488-T01-IM5 Cutaneous Melanoma G476K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation DNP diploid NA NA NA 19 10600428 10600429 CC TT 19:g.10600428_10600429delinsTT ENST00000171111.5:c.1426_1427delinsAA 0.09 148 1456 6 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005554-T01-IM5 Large Cell Neuroendocrine Carcinoma G523V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10600008 10600008 C A 19:g.10600008C>A ENST00000171111.5:c.1568G>T 0.67 553 268 10 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010610-T01-IM5 Non-Small Cell Lung Cancer G523V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10600008 10600008 C A 19:g.10600008C>A ENST00000171111.5:c.1568G>T 0.51 304 287 14 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011186-T01-IM5 Lung Adenocarcinoma G509A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: probably_damaging, score: 0.992 Missense_Mutation SNP diploid 1 NA NA NA 19 10600329 10600329 C G 19:g.10600329C>G ENST00000171111.5:c.1526G>C 0.69 809 366 9 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012400-T01-IM5 Large Cell Neuroendocrine Carcinoma G364F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation DNP diploid 2 NA NA NA 19 10602487 10602488 CC AA 19:g.10602487_10602488delinsAA ENST00000171111.5:c.1090_1091delinsTT 0.25 232 708 32 3/6 Pancreatic Adenocarcinoma (QCMG, Nature 2016) ICGC_0216 Pancreatic Adenocarcinoma M550I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP 1 Somatic NA qcmg.uq.edu.au 19 10599926 10599926 C T 19:g.10599926C>T ENST00000171111.5:c.1650G>A 18 5/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-S00488 Lung Adenocarcinoma G364C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10602488 10602488 C A 19:g.10602488C>A ENST00000171111.5:c.1090G>T 440 3/6 rs1397945617 Thyroid Carcinoma (TCGA, PanCancer Atlas) TCGA-BJ-A192-01 Papillary Thyroid Cancer G477S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel 1 . . . 19 10600426 10600426 C T 19:g.10600426C>T ENST00000171111.5:c.1429G>A 0.55 11 9 52 11 4/6 0.00000397757 rs766297018 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-43-2578-01 Lung Squamous Cell Carcinoma V167F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP shallowdel 1 . . . 19 10610211 10610211 C A 19:g.10610211C>A ENST00000171111.5:c.499G>T 0.42 30 42 89 294 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-34-2605-01 Lung Squamous Cell Carcinoma I145M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.993 Missense_Mutation SNP gain . . . 19 10610275 10610275 G C 19:g.10610275G>C ENST00000171111.5:c.435C>G 0.18 18 81 108 326 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-R1 Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 0.32 97 207 605 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-R2 Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 0.06 16 245 569 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-R3 Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 0.15 46 264 582 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-R4 Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 0.08 17 205 604 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-Pre-ctDNA Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 28 4/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0052-Post-ctDNA Non-Small Cell Lung Cancer D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 28 4/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-ED-A4XI-01 Hepatocellular Carcinoma Y525C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10600002 10600002 T C 19:g.10600002T>C ENST00000171111.5:c.1574A>G 0.06 8 128 175 139 5/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AAEG-01 Hepatocellular Carcinoma G429D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10602292 10602292 C T 19:g.10602292C>T ENST00000171111.5:c.1286G>A 0.11 4 33 72 102 3/6 Diffuse Large B cell Lymphoma (DFCI, Nat Med 2018) DLBCL-MAYO_DLBCL_234 Germinal Center B-Cell Type A159T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.976 Missense_Mutation SNP 1 NA NA broad.mit.edu 19 10610235 10610235 C T 19:g.10610235C>T ENST00000171111.5:c.475G>A 0.37 19 33 4284 2/6 Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CM-6674-01 Colon Adenocarcinoma D165N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.53;Polyphen-2: impact: benign, score: 0.089 Missense_Mutation SNP diploid 2 . . . 19 10610217 10610217 C T 19:g.10610217C>T ENST00000171111.5:c.493G>A 0.21 14 54 58 838 2/6 0.00000398791 rs752325770 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CV-5978-01 Head and Neck Squamous Cell Carcinoma I145F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.99 Missense_Mutation SNP diploid . . . 19 10610277 10610277 T A 19:g.10610277T>A ENST00000171111.5:c.433A>T 0.27 14 37 58 159 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-UF-A7JF-01 Head and Neck Squamous Cell Carcinoma Y525C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10600002 10600002 T C 19:g.10600002T>C ENST00000171111.5:c.1574A>G 0.24 12 38 59 89 5/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-KU-A66S-01 Head and Neck Squamous Cell Carcinoma G429S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10602293 10602293 C T 19:g.10602293C>T ENST00000171111.5:c.1285G>A 0.21 6 23 45 478 3/6 rs1320679251 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) CU9061 Lung Squamous Cell Carcinoma E488K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 1 NA NA NA 19 10600393 10600393 C T 19:g.10600393C>T ENST00000171111.5:c.1462G>A 0.77 63 19 343 4/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) FR9547 Lung Adenocarcinoma G509W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 1 NA NA NA 19 10600330 10600330 C A 19:g.10600330C>A ENST00000171111.5:c.1525G>T 0.43 54 73 268 4/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) M4945 Lung Adenocarcinoma G476V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP NA NA NA 19 10600428 10600428 C A 19:g.10600428C>A ENST00000171111.5:c.1427G>T 0.35 25 47 283 4/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) SU2C_Lung-SU2C-DFCI-LUAD-1004-Tumor-SM-AOL4P Lung Adenocarcinoma V475L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP 1 NA NA NA 19 10600432 10600432 C A 19:g.10600432C>A ENST00000171111.5:c.1423G>T 0.14 19 113 115 4/6 rs547713274 Metastatic Solid Cancers (UMich, Nature 2017) MO_1542 Poorly Differentiated Carcinoma, NOS R460S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 4 NA NA University of Michigan 19 10600475 10600475 C G 19:g.10600475C>G ENST00000171111.5:c.1380G>C 0.31 163 364 420 36 4/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-BS-A0TA-01 Uterine Endometrioid Carcinoma R169C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.663 Missense_Mutation SNP diploid 1 . . . 19 10610205 10610205 G A 19:g.10610205G>A ENST00000171111.5:c.505C>T 0.28 27 69 13 471 2/6 0.0000119565 rs539818436 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-B5-A0JY-01 Uterine Endometrioid Carcinoma E488D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 1 . . . 19 10600391 10600391 C A 19:g.10600391C>A ENST00000171111.5:c.1464G>T 0.29 35 85 58 9706 4/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-A5-A0G2-01 Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma G509R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 . . . 19 10600330 10600330 C T 19:g.10600330C>T ENST00000171111.5:c.1525G>A 0.42 20 28 49 25711 4/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-DI-A1BU-01 Uterine Mixed Endometrial Carcinoma V167I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.1;Polyphen-2: impact: possibly_damaging, score: 0.817 Missense_Mutation SNP diploid 1 . . . 19 10610211 10610211 C T 19:g.10610211C>T ENST00000171111.5:c.499G>A 0.39 9 14 10 7642 2/6 0.000031837 rs749396788 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-5899-01 Lung Adenocarcinoma G509W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10600330 10600330 C A 19:g.10600330C>A ENST00000171111.5:c.1525G>T 0.67 28 14 48 387 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-86-8674-01 Lung Adenocarcinoma G476V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10600428 10600428 C A 19:g.10600428C>A ENST00000171111.5:c.1427G>T 0.44 21 27 85 268 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z030-01 Lung Adenocarcinoma I145F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.99 Missense_Mutation SNP . . . 19 10610277 10610277 T A 19:g.10610277T>A ENST00000171111.5:c.433A>T 0.23 5 17 27 527 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-05-4395-01 Lung Adenocarcinoma D479G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP shallowdel 1 . . . 19 10600419 10600419 T C 19:g.10600419T>C ENST00000171111.5:c.1436A>G 0.47 26 29 63 230 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-05-4418-01 Lung Adenocarcinoma R460G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 4 . . . 19 10600477 10600477 T C 19:g.10600477T>C ENST00000171111.5:c.1378A>G 0.36 15 27 53 246 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-38-4631-01 Lung Adenocarcinoma F139L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP shallowdel 1 . . . 19 10610293 10610293 G T 19:g.10610293G>T ENST00000171111.5:c.417C>A 0.38 10 16 48 687 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7158-01 Lung Adenocarcinoma I461V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.22;Polyphen-2: impact: possibly_damaging, score: 0.484 Missense_Mutation SNP diploid 1 . . . 19 10600474 10600474 T C 19:g.10600474T>C ENST00000171111.5:c.1381A>G 0.44 12 15 21 249 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-91-6849-01 Lung Adenocarcinoma A159P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP shallowdel 1 . . . 19 10610235 10610235 C G 19:g.10610235C>G ENST00000171111.5:c.475G>C 0.41 39 55 85 109 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8085-01 Lung Adenocarcinoma G429V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10602292 10602292 C A 19:g.10602292C>A ENST00000171111.5:c.1286G>T 0.36 19 34 76 226 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-62-A46O-01 Lung Adenocarcinoma G509V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10600329 10600329 C A 19:g.10600329C>A ENST00000171111.5:c.1526G>T 0.82 37 8 56 799 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7162-01 Lung Adenocarcinoma A159S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.873 Missense_Mutation SNP shallowdel 1 . . . 19 10610235 10610235 C A 19:g.10610235C>A ENST00000171111.5:c.475G>T 0.14 6 36 48 73 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-97-8176-01 Lung Adenocarcinoma G523E OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10600008 10600008 C T 19:g.10600008C>T ENST00000171111.5:c.1568G>A 0.49 28 29 60 138 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-6743-01 Lung Adenocarcinoma G527V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10599996 10599996 C A 19:g.10599996C>A ENST00000171111.5:c.1580G>T 0.30 0.02 9 21 1 41 689 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-6743-01 Lung Adenocarcinoma G527C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10599997 10599997 C A 19:g.10599997C>A ENST00000171111.5:c.1579G>T 0.30 0.02 9 21 1 41 689 5/6 Breast Invasive Carcinoma (TCGA, PanCancer Atlas) TCGA-AN-A046-01 Breast Invasive Ductal Carcinoma D165N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.53;Polyphen-2: impact: benign, score: 0.089 Missense_Mutation SNP diploid 2 . . . 19 10610217 10610217 C T 19:g.10610217C>T ENST00000171111.5:c.493G>A 0.10 5 44 85 5392 2/6 0.00000398791 rs752325770 Esophageal Squamous Cell Carcinoma (ICGC, Nature 2014) ESCC-210T Esophageal Squamous Cell Carcinoma N485S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.85;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP 1 Somatic NA BGI 19 10600401 10600401 T C 19:g.10600401T>C ENST00000171111.5:c.1454A>G 0.21 0.01 13 48 1 96 81 4/6 Bladder Urothelial Carcinoma (DFCI/MSKCC, Cancer Discov 2014) MSKCC-0820_NR Bladder Urothelial Carcinoma D479H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 1 NA NA NA 19 10600420 10600420 C G 19:g.10600420C>G ENST00000171111.5:c.1435G>C 80 4/6 Skin Cutaneous Melanoma (Yale, Nat Genet 2012) YURIF Cutaneous Melanoma R459Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.26;Polyphen-2: impact: benign, score: 0.001 Missense_Mutation SNP 1 somatic NA yale.edu 19 10600479 10600479 C T 19:g.10600479C>T ENST00000171111.5:c.1376G>A 282 4/6 0.000019917303353936093 rs145311080 Skin Cutaneous Melanoma (Yale, Nat Genet 2012) YURTHE Cutaneous Melanoma V475L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: yes MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP 1 somatic NA yale.edu 19 10600432 10600432 C G 19:g.10600432C>G ENST00000171111.5:c.1423G>C 660 4/6 Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) S04-32572-TP-S06-19548-NT Cutaneous Squamous Cell Carcinoma C613R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP Somatic Untested broad.mit.edu 19 10597366 10597366 A G 19:g.10597366A>G ENST00000171111.5:c.1837T>C 20 6/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A183 Lung Adenocarcinoma E218V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.691 Missense_Mutation SNP deepdel 4 NA NA NA 19 10602925 10602925 T A 19:g.10602925T>A ENST00000171111.5:c.653A>T 0.19 16 68 564 3/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-RS31 Lung Adenocarcinoma R116W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.96 Missense_Mutation SNP diploid 2 NA NA NA 19 10610364 10610364 G A 19:g.10610364G>A ENST00000171111.5:c.346C>T 0.19 5 22 82 2/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A158 Lung Adenocarcinoma C171F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel NA NA NA 19 10610198 10610198 C A 19:g.10610198C>A ENST00000171111.5:c.512G>T 0.51 18 17 74 2/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-EX05 Lung Adenocarcinoma T277M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.727 Missense_Mutation SNP diploid NA NA NA 19 10602748 10602748 G A 19:g.10602748G>A ENST00000171111.5:c.830C>T 0.30 16 37 48 3/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) BGI-EX06 Lung Adenocarcinoma N238S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.433 Missense_Mutation SNP shallowdel NA NA NA 19 10602865 10602865 T C 19:g.10602865T>C ENST00000171111.5:c.713A>G 0.32 8 17 257 3/6 Lung Adenocarcinoma (OncoSG, Nat Genet 2020) A196 Lung Adenocarcinoma G558W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10599904 10599904 C A 19:g.10599904C>A ENST00000171111.5:c.1672G>T 0.06 4 64 47 5/6 Lung Cancer (SMC, Cancer Research 2016) TH3_Primary_LUL Lung Squamous Cell Carcinoma L471V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: benign, score: 0.124 Missense_Mutation SNP NA NA NA 19 10600444 10600444 G C 19:g.10600444G>C ENST00000171111.5:c.1411C>G 0.14 9 56 430 4/6 Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) TCGA-24-1474-01 Serous Ovarian Cancer N189K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.34;Polyphen-2: impact: benign, score: 0.136 Missense_Mutation SNP amp 1 . . . 19 10610143 10610143 G C 19:g.10610143G>C ENST00000171111.5:c.567C>G 0.12 23 177 61 80 2/6 Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) TCGA-61-1919-01 Serous Ovarian Cancer M503V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.968 Missense_Mutation SNP gain 2 . . . 19 10600348 10600348 T C 19:g.10600348T>C ENST00000171111.5:c.1507A>G 0.07 5 71 38 79 4/6 0.00000795286 rs369132814 Upper Tract Urothelial Carcinoma (IGBMC, Genome Biology 2021) UTUC_28T Upper Tract Urothelial Carcinoma E289D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.89;Polyphen-2: impact: benign, score: 0.01 Missense_Mutation SNP NA NA NA 19 10602711 10602711 C A 19:g.10602711C>A ENST00000171111.5:c.867G>T 264 3/6 Pediatric Preclinical Testing Consortium (CHOP, Cell Rep 2019) ALL-115 B-Lymphoblastic Leukemia/Lymphoma R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP 1 NA NA hgsc.bcm.edu 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.49 0.49 118 124 118 124 127 3/6 Pediatric Preclinical Testing Consortium (CHOP, Cell Rep 2019) ICb-3130MB Medulloblastoma T598I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.08;Polyphen-2: impact: benign, score: 0.172 Missense_Mutation SNP NA NA hgsc.bcm.edu 19 10597410 10597410 G A 19:g.10597410G>A ENST00000171111.5:c.1793C>T 0.36 0.36 26 46 26 46 120 6/6 0.00007954436981923364 rs142262195 Pediatric Preclinical Testing Consortium (CHOP, Cell Rep 2019) IC-1621GBM Glioblastoma T400S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.21;Polyphen-2: impact: benign, score: 0.015 Missense_Mutation SNP NA NA hgsc.bcm.edu 19 10602380 10602380 T A 19:g.10602380T>A ENST00000171111.5:c.1198A>T 0.40 0.40 57 85 57 85 6798 3/6 0.00000510397 rs764748628 Pediatric Preclinical Testing Consortium (CHOP, Cell Rep 2019) OS-42 Osteosarcoma N397S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: possibly_damaging, score: 0.902 Missense_Mutation SNP NA NA hgsc.bcm.edu 19 10602388 10602388 T C 19:g.10602388T>C ENST00000171111.5:c.1190A>G 0.17 0.17 72 359 72 359 204 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s68 Lung Adenocarcinoma D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP 4 NA NA MSKCC 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 0.39 62 96 502 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s52 Lung Adenocarcinoma V568F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP NA NA MSKCC 19 10599874 10599874 C A 19:g.10599874C>A ENST00000171111.5:c.1702G>T 0.06 5 73 178 5/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s41 Lung Adenocarcinoma G332S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA MSKCC 19 10602584 10602584 C T 19:g.10602584C>T ENST00000171111.5:c.994G>A 0.76 58 18 893 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s57 Lung Adenocarcinoma T277M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.727 Missense_Mutation SNP NA NA MSKCC 19 10602748 10602748 G A 19:g.10602748G>A ENST00000171111.5:c.830C>T 0.47 79 88 131 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s75 Lung Adenocarcinoma D294V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.005 Missense_Mutation SNP NA NA MSKCC 19 10602697 10602697 T A 19:g.10602697T>A ENST00000171111.5:c.881A>T 0.56 178 141 387 3/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s56 Lung Adenocarcinoma V98A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.67 Missense_Mutation SNP NA NA MSKCC 19 10610417 10610417 A G 19:g.10610417A>G ENST00000171111.5:c.293T>C 0.26 17 49 172 2/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s48 Lung Adenocarcinoma A109T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP NA NA MSKCC 19 10610385 10610385 C T 19:g.10610385C>T ENST00000171111.5:c.325G>A 0.39 64 102 120 2/6 Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018s54 Lung Adenocarcinoma H210D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: benign, score: 0.433 Missense_Mutation SNP NA NA MSKCC 19 10610082 10610082 G C 19:g.10610082G>C ENST00000171111.5:c.628C>G 0.44 12 15 377 2/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-AQ2TB1 Adenoid Cystic Carcinoma T543M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.285 Missense_Mutation SNP diploid SOMATIC unknown Foundation 19 10599948 10599948 G A 19:g.10599948G>A ENST00000171111.5:c.1628C>T 0.50 310 310 9 5/6 0.000007959121948655732 rs111830952 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-HNQMN1 Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597343 10597345 CTG - 19:g.10597343_10597345del ENST00000171111.5:c.1858_1860del 0.54 454 383 11 6/6 0.002394384133164424 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-B9ALTG Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.45 249 304 7 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-37399H Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.48 255 276 7 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-XBTHWQ Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.45 324 395 8 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-HGKDNP Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.49 327 341 6 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-C7R703 Adenoid Cystic Carcinoma of the Lung Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.48 327 355 8 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-L0Y7XT Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.48 184 199 7 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-300QUS Adenoid Cystic Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC unknown Foundation 19 10597346 10597348 CTG - 19:g.10597346_10597348del ENST00000171111.5:c.1858_1860del 0.46 241 282 4 6/6 Adenoid Cystic Carcinoma Project (J Clin Invest 2019) XRN-QCU3JJ Adenoid Cystic Carcinoma F211S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid SOMATIC unknown Foundation 19 10610078 10610078 A G 19:g.10610078A>G ENST00000171111.5:c.632T>C 0.48 307 332 8 2/6 rs1023362212 Prostate Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CH-5792-01 Prostate Adenocarcinoma A407V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.197 Missense_Mutation SNP diploid 1 . . . 19 10602358 10602358 G A 19:g.10602358G>A ENST00000171111.5:c.1220C>T 0.22 5 18 15 33 3/6 rs1371897807 Prostate Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-EJ-A46G-01 Prostate Adenocarcinoma R354L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: benign, score: 0.213 Missense_Mutation SNP diploid 1 . . . 19 10602517 10602517 C A 19:g.10602517C>A ENST00000171111.5:c.1061G>T 0.25 3 9 10 48 3/6 0.00000426993 rs780969499 Prostate Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-XK-AAIW-01 Prostate Adenocarcinoma A95T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.526 Missense_Mutation SNP diploid 1 . . . 19 10610427 10610427 C T 19:g.10610427C>T ENST00000171111.5:c.283G>A 0.38 6 10 29 6234 2/6 Prostate Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-KK-A59V-01 Prostate Adenocarcinoma D585N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0.059 Missense_Mutation SNP diploid . . . 19 10597450 10597450 C T 19:g.10597450C>T ENST00000171111.5:c.1753G>A 0.27 37 101 154 764 6/6 0.0000358143 rs200652594 Pediatric Pan-cancer (Columbia U, Genome Med 2016) PIP15-63375-T1 Acute Myeloid Leukemia V369A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.166 Missense_Mutation SNP 1 NA NA . 19 10602472 10602472 A G 19:g.10602472A>G ENST00000171111.5:c.1106T>C 236 3/6 0.0012347119274089616 Likely benign rs149721624 Kidney Renal Clear Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-B0-4815-01 Renal Clear Cell Carcinoma W544R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 . . . 19 10599946 10599946 A G 19:g.10599946A>G ENST00000171111.5:c.1630T>C 0.22 14 49 58 60 5/6 Kidney Renal Clear Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-BP-5183-01 Renal Clear Cell Carcinoma M409T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.848 Missense_Mutation SNP diploid 1 . . . 19 10602352 10602352 A G 19:g.10602352A>G ENST00000171111.5:c.1226T>C 0.38 8 13 22 42 3/6 Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-VR-A8EU-01 Esophageal Squamous Cell Carcinoma V271M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.95 Missense_Mutation SNP diploid 1 . . . 19 10602767 10602767 C T 19:g.10602767C>T ENST00000171111.5:c.811G>A 0.19 4 17 28 84 3/6 Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-L5-A43J-01 Esophageal Squamous Cell Carcinoma V264I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.19;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP gain . . . 19 10602788 10602788 C T 19:g.10602788C>T ENST00000171111.5:c.790G>A 0.37 33 56 34 699 3/6 rs755995530 Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-L5-A88Z-01 Esophageal Squamous Cell Carcinoma R413H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10602340 10602340 C T 19:g.10602340C>T ENST00000171111.5:c.1238G>A 0.37 13 22 24 67 3/6 Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-L5-A8NM-01 Esophageal Adenocarcinoma V152A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid . . . 19 10610255 10610255 A G 19:g.10610255A>G ENST00000171111.5:c.455T>C 0.18 3 14 16 1432 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012065-T01-IM5 Lung Adenocarcinoma T142M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10610285 10610285 G A 19:g.10610285G>A ENST00000171111.5:c.425C>T 0.17 172 850 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009995-T01-IM5 Lung Adenocarcinoma R234P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.806 Missense_Mutation SNP diploid NA NA NA 19 10602877 10602877 C G 19:g.10602877C>G ENST00000171111.5:c.701G>C 0.32 303 638 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003722-T01-IM5 Lung Adenocarcinoma C196F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.981 Missense_Mutation SNP diploid NA NA NA 19 10610123 10610123 C A 19:g.10610123C>A ENST00000171111.5:c.587G>T 0.35 240 454 12 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006540-T01-IM5 Lung Squamous Cell Carcinoma D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP diploid 4 NA NA NA 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 0.14 95 588 12 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002964-T02-IM3 Papillary Renal Cell Carcinoma L237M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.966 Missense_Mutation SNP diploid 1 NA NA NA 19 10602869 10602869 G T 19:g.10602869G>T ENST00000171111.5:c.709C>A 0.48 210 223 47 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008874-T01-IM5 Lung Adenocarcinoma Y572C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.782 Missense_Mutation SNP diploid 2 NA NA NA 19 10597488 10597488 T C 19:g.10597488T>C ENST00000171111.5:c.1715A>G 0.10 59 554 11 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012155-T01-IM5 Cholangiocarcinoma E149K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.988 Missense_Mutation SNP diploid NA NA NA 19 10610265 10610265 C T 19:g.10610265C>T ENST00000171111.5:c.445G>A 0.45 617 763 3 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001878-T01-IM3 Leiomyosarcoma A30T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.43;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP diploid NA NA NA 19 10610622 10610622 C T 19:g.10610622C>T ENST00000171111.5:c.88G>A 0.27 150 408 28 2/6 0.000016125521053827213 rs537634437 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000459-T01-IM3 Lung Adenocarcinoma H311R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.2;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid 2 NA NA NA 19 10602646 10602646 T C 19:g.10602646T>C ENST00000171111.5:c.932A>G 0.42 39 53 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001944-T01-IM3 Lung Adenocarcinoma G603W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10597396 10597396 C A 19:g.10597396C>A ENST00000171111.5:c.1807G>T 0.10 57 486 5 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009643-T01-IM5 Lung Adenocarcinoma R71L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10610498 10610498 C A 19:g.10610498C>A ENST00000171111.5:c.212G>T 0.21 22 84 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005309-T01-IM5 Adenocarcinoma, NOS D389Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10602413 10602413 C A 19:g.10602413C>A ENST00000171111.5:c.1165G>T 0.20 161 631 26 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008763-T01-IM5 Adenocarcinoma, NOS G419W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10602323 10602323 C A 19:g.10602323C>A ENST00000171111.5:c.1255G>T 0.36 389 679 14 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010609-T01-IM5 Lung Adenocarcinoma P278S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.96 Missense_Mutation SNP diploid 2 NA NA NA 19 10602746 10602746 G A 19:g.10602746G>A ENST00000171111.5:c.832C>T 0.61 485 304 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012308-T01-IM5 Lung Adenocarcinoma R204P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.968 Missense_Mutation SNP diploid 1 NA NA NA 19 10610099 10610099 C G 19:g.10610099C>G ENST00000171111.5:c.611G>C 0.07 65 821 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007071-T01-IM5 Gallbladder Cancer S102L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.971 Missense_Mutation SNP diploid 1 NA NA NA 19 10610405 10610405 G A 19:g.10610405G>A ENST00000171111.5:c.305C>T 0.33 199 404 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011334-T01-IM5 Poorly Differentiated Non-Small Cell Lung Cancer S102L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.971 Missense_Mutation SNP diploid 1 NA NA NA 19 10610405 10610405 G A 19:g.10610405G>A ENST00000171111.5:c.305C>T 0.61 309 197 49 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011334-T02-IM5 Poorly Differentiated Non-Small Cell Lung Cancer S102L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.971 Missense_Mutation SNP diploid 1 NA NA NA 19 10610405 10610405 G A 19:g.10610405G>A ENST00000171111.5:c.305C>T 0.41 346 499 46 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005783-T01-IM5 Cancer of Unknown Primary A95T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.526 Missense_Mutation SNP diploid 1 NA NA NA 19 10610427 10610427 C T 19:g.10610427C>T ENST00000171111.5:c.283G>A 0.63 935 540 67 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009590-T01-IM5 Lung Adenocarcinoma A95T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.526 Missense_Mutation SNP diploid 1 NA NA NA 19 10610427 10610427 C T 19:g.10610427C>T ENST00000171111.5:c.283G>A 0.27 158 417 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005002-T01-IM5 Poorly Differentiated Non-Small Cell Lung Cancer R116P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.905 Missense_Mutation SNP diploid 2 NA NA NA 19 10610363 10610363 C G 19:g.10610363C>G ENST00000171111.5:c.347G>C 0.63 275 162 12 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002709-T01-IM3 Large Cell Lung Carcinoma P318L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.759 Missense_Mutation SNP diploid 1 NA NA NA 19 10602625 10602625 G A 19:g.10602625G>A ENST00000171111.5:c.953C>T 0.62 251 157 30 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004755-T01-IM5 Bladder Urothelial Carcinoma S275L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.64;Polyphen-2: impact: benign, score: 0.086 Missense_Mutation SNP diploid NA NA NA 19 10602754 10602754 G A 19:g.10602754G>A ENST00000171111.5:c.824C>T 0.48 404 441 51 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000062-T01-IM3 Adenocarcinoma of the Gastroesophageal Junction I425M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.11;Polyphen-2: impact: possibly_damaging, score: 0.809 Missense_Mutation SNP diploid NA NA NA 19 10602303 10602303 G C 19:g.10602303G>C ENST00000171111.5:c.1275C>G 0.34 422 807 6 3/6 0.000017396 rs754011905 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000083-T01-IM3 Bladder Urothelial Carcinoma N382K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP diploid NA NA NA 19 10602432 10602432 G C 19:g.10602432G>C ENST00000171111.5:c.1146C>G 0.22 138 500 116 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000083-T01-IM3 Bladder Urothelial Carcinoma P313A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.48;Polyphen-2: impact: possibly_damaging, score: 0.541 Missense_Mutation SNP diploid NA NA NA 19 10602641 10602641 G C 19:g.10602641G>C ENST00000171111.5:c.937C>G 0.27 127 343 116 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006071-T01-IM5 Lung Adenocarcinoma R507L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid NA NA NA 19 10600335 10600335 C A 19:g.10600335C>A ENST00000171111.5:c.1520G>T 0.77 486 146 17 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000991-T01-IM3 Esophageal Adenocarcinoma R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP diploid 1 NA NA NA 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.52 123 112 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001365-T02-IM3 Lung Adenocarcinoma R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP diploid 1 NA NA NA 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.06 23 366 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008494-T01-IM5 Gallbladder Cancer R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP diploid 1 NA NA NA 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.48 236 256 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010088-T01-IM5 Oropharynx Squamous Cell Carcinoma R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP diploid 1 NA NA NA 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.23 139 462 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000323-T01-IM3 Small Cell Lung Cancer V271M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.95 Missense_Mutation SNP diploid 1 NA NA NA 19 10602767 10602767 C T 19:g.10602767C>T ENST00000171111.5:c.811G>A 0.44 482 626 13 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003964-T01-IM3 Lung Adenocarcinoma G332C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602584 10602584 C A 19:g.10602584C>A ENST00000171111.5:c.994G>T 0.32 127 275 9 3/6 rs1208201314 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007099-T01-IM5 Lung Adenocarcinoma G332C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602584 10602584 C A 19:g.10602584C>A ENST00000171111.5:c.994G>T 0.20 149 606 11 3/6 rs1208201314 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008876-T01-IM5 Lung Adenocarcinoma G332C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602584 10602584 C A 19:g.10602584C>A ENST00000171111.5:c.994G>T 0.29 200 489 18 3/6 rs1208201314 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001836-T01-IM3 Lung Adenocarcinoma C171F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10610198 10610198 C A 19:g.10610198C>A ENST00000171111.5:c.512G>T 0.50 510 506 21 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008948-T01-IM5 Large Cell Neuroendocrine Carcinoma R234W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP diploid NA NA NA 19 10602878 10602878 G A 19:g.10602878G>A ENST00000171111.5:c.700C>T 0.44 142 182 5 3/6 Uncertain significance rs1599484704 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010736-T01-IM5 Lung Adenocarcinoma H274R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.393 Missense_Mutation SNP diploid NA NA NA 19 10602757 10602757 T C 19:g.10602757T>C ENST00000171111.5:c.821A>G 0.25 145 444 26 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005849-T01-IM5 Lung Adenocarcinoma V123L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.871 Missense_Mutation SNP diploid 1 NA NA NA 19 10610343 10610343 C A 19:g.10610343C>A ENST00000171111.5:c.367G>T 0.37 360 617 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002669-T01-IM3 Large Cell Neuroendocrine Carcinoma W591L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10597431 10597431 C A 19:g.10597431C>A ENST00000171111.5:c.1772G>T 0.75 256 84 21 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012394-T01-IM5 Cancer of Unknown Primary W591L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10597431 10597431 C A 19:g.10597431C>A ENST00000171111.5:c.1772G>T 0.85 970 173 17 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008850-T01-IM5 Lung Squamous Cell Carcinoma E219Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.677 Missense_Mutation SNP diploid NA NA NA 19 10602923 10602923 C G 19:g.10602923C>G ENST00000171111.5:c.655G>C 0.25 227 674 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004858-T01-IM5 Lung Adenocarcinoma P130L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10610321 10610321 G A 19:g.10610321G>A ENST00000171111.5:c.389C>T 0.17 80 392 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004858-T02-IM5 Lung Adenocarcinoma P130L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10610321 10610321 G A 19:g.10610321G>A ENST00000171111.5:c.389C>T 0.43 311 408 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001348-T02-IM3 Large Cell Neuroendocrine Carcinoma R269W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.663 Missense_Mutation SNP diploid 1 NA NA NA 19 10602773 10602773 G A 19:g.10602773G>A ENST00000171111.5:c.805C>T 0.06 43 674 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001348-T01-IM3 Large Cell Neuroendocrine Carcinoma R269W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.663 Missense_Mutation SNP diploid 1 NA NA NA 19 10602773 10602773 G A 19:g.10602773G>A ENST00000171111.5:c.805C>T 0.82 184 40 12 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009110-T01-IM5 Lung Adenocarcinoma R413H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602340 10602340 C T 19:g.10602340C>T ENST00000171111.5:c.1238G>A 0.09 90 920 17 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005230-T01-IM5 Colorectal Adenocarcinoma D585N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0.059 Missense_Mutation SNP diploid NA NA NA 19 10597450 10597450 C T 19:g.10597450C>T ENST00000171111.5:c.1753G>A 0.07 45 621 65 6/6 0.0000358143 rs200652594 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006461-T01-IM5 Prostate Adenocarcinoma A63V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: probably_damaging, score: 0.965 Missense_Mutation SNP diploid 2 NA NA NA 19 10610522 10610522 G A 19:g.10610522G>A ENST00000171111.5:c.188C>T 0.18 139 640 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005197-T01-IM5 Colon Adenocarcinoma R336Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.25;Polyphen-2: impact: benign, score: 0.185 Missense_Mutation SNP diploid NA NA NA 19 10602571 10602571 C T 19:g.10602571C>T ENST00000171111.5:c.1007G>A 0.08 79 870 60 3/6 0.0000040405 rs1352112075 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002872-T01-IM3 Poorly Differentiated Non-Small Cell Lung Cancer R261W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.17;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP diploid 1 NA NA NA 19 10602797 10602797 G A 19:g.10602797G>A ENST00000171111.5:c.781C>T 0.34 233 446 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004135-T01-IM5 Choriocarcinoma R261W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.17;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP diploid 1 NA NA NA 19 10602797 10602797 G A 19:g.10602797G>A ENST00000171111.5:c.781C>T 0.28 138 350 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010581-T01-IM5 Rectal Adenocarcinoma R15Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.25;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP diploid 1 NA NA NA 19 10610666 10610666 C T 19:g.10610666C>T ENST00000171111.5:c.44G>A 0.27 128 344 68 2/6 0.00017623474443229981 rs144429440 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007495-T01-IM5 Rectal Adenocarcinoma S103F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.961 Missense_Mutation SNP diploid NA NA NA 19 10610402 10610402 G A 19:g.10610402G>A ENST00000171111.5:c.308C>T 0.15 99 544 14 2/6 0.00000398298 rs1186163503 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008485-T01-IM5 Lung Adenocarcinoma A184T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.927 Missense_Mutation SNP diploid NA NA NA 19 10610160 10610160 C T 19:g.10610160C>T ENST00000171111.5:c.550G>A 0.07 34 450 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006950-T01-IM5 Lung Adenocarcinoma G558R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10599904 10599904 C T 19:g.10599904C>T ENST00000171111.5:c.1672G>A 0.65 401 217 3 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009168-T01-IM5 Lung Adenocarcinoma G558R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10599904 10599904 C T 19:g.10599904C>T ENST00000171111.5:c.1672G>A 0.21 261 956 29 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006728-T01-IM5 Lung Adenocarcinoma G511S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid NA NA NA 19 10600324 10600324 C T 19:g.10600324C>T ENST00000171111.5:c.1531G>A 0.64 308 172 14 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001130-T01-IM3 Lung Adenocarcinoma E192K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.642 Missense_Mutation SNP diploid NA NA NA 19 10610136 10610136 C T 19:g.10610136C>T ENST00000171111.5:c.574G>A 0.35 348 658 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003165-T01-IM5 Lung Adenocarcinoma E192K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.642 Missense_Mutation SNP diploid NA NA NA 19 10610136 10610136 C T 19:g.10610136C>T ENST00000171111.5:c.574G>A 0.33 262 531 24 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008723-T01-IM5 Lung Adenocarcinoma E192K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: possibly_damaging, score: 0.642 Missense_Mutation SNP diploid NA NA NA 19 10610136 10610136 C T 19:g.10610136C>T ENST00000171111.5:c.574G>A 0.06 61 994 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002886-T01-IM3 Lung Adenocarcinoma G571R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid NA NA NA 19 10597492 10597492 C G 19:g.10597492C>G ENST00000171111.5:c.1711G>C 0.18 110 504 17 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000897-T01-IM3 Large Cell Neuroendocrine Carcinoma G603V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10597395 10597395 C A 19:g.10597395C>A ENST00000171111.5:c.1808G>T 0.59 139 95 14 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000924-T01-IM3 Lung Adenocarcinoma G603V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10597395 10597395 C A 19:g.10597395C>A ENST00000171111.5:c.1808G>T 0.43 274 363 8 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005190-T01-IM5 Lung Adenocarcinoma G603V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 NA NA NA 19 10597395 10597395 C A 19:g.10597395C>A ENST00000171111.5:c.1808G>T 0.51 247 236 4 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004054-T01-IM5 Lung Adenocarcinoma A556T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 1 NA NA NA 19 10599910 10599910 C T 19:g.10599910C>T ENST00000171111.5:c.1666G>A 0.50 231 229 14 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007688-T01-IM5 Colon Adenocarcinoma L291M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.77 Missense_Mutation SNP diploid NA NA NA 19 10602707 10602707 G T 19:g.10602707G>T ENST00000171111.5:c.871C>A 0.23 156 537 52 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001622-T01-IM3 Lung Squamous Cell Carcinoma E117D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10610359 10610359 C A 19:g.10610359C>A ENST00000171111.5:c.351G>T 0.59 706 486 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008922-T01-IM5 Lung Adenocarcinoma E117D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10610359 10610359 C A 19:g.10610359C>A ENST00000171111.5:c.351G>T 0.06 34 548 3 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008922-T02-IM5 Lung Adenocarcinoma E117D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10610359 10610359 C A 19:g.10610359C>A ENST00000171111.5:c.351G>T 0.27 176 468 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006753-T01-IM5 Colon Adenocarcinoma T36A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.85;Polyphen-2: impact: benign, score: 0.037 Missense_Mutation SNP diploid NA NA NA 19 10610604 10610604 T C 19:g.10610604T>C ENST00000171111.5:c.106A>G 0.08 48 556 57 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008929-T01-IM5 Lung Adenocarcinoma D448G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.893 Missense_Mutation SNP diploid NA NA NA 19 10600512 10600512 T C 19:g.10600512T>C ENST00000171111.5:c.1343A>G 0.13 162 1094 16 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004087-T01-IM5 Lung Adenocarcinoma M133R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.915 Missense_Mutation SNP diploid NA NA NA 19 10610312 10610312 A C 19:g.10610312A>C ENST00000171111.5:c.398T>G 0.77 377 112 17 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006612-T01-IM5 Colon Adenocarcinoma R596Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.69;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP diploid NA NA NA 19 10597416 10597416 C T 19:g.10597416C>T ENST00000171111.5:c.1787G>A 0.25 276 816 357 6/6 rs1190115073 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005510-T01-IM5 Lung Adenocarcinoma V132G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.979 Missense_Mutation SNP diploid NA NA NA 19 10610315 10610315 A C 19:g.10610315A>C ENST00000171111.5:c.395T>G 0.21 290 1089 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003586-T01-IM5 Lung Adenocarcinoma S224F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP diploid 1 NA NA NA 19 10602907 10602907 G A 19:g.10602907G>A ENST00000171111.5:c.671C>T 0.72 227 90 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004011-T01-IM5 Colon Adenocarcinoma R447W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.735 Missense_Mutation SNP diploid NA NA NA 19 10600516 10600516 G A 19:g.10600516G>A ENST00000171111.5:c.1339C>T 0.06 24 372 65 4/6 rs1384602464 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009955-T01-IM5 Non-Small Cell Lung Cancer R483H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.806 Missense_Mutation SNP diploid 2 NA NA NA 19 10600407 10600407 C T 19:g.10600407C>T ENST00000171111.5:c.1448G>A 0.09 187 1861 2 4/6 0.000003977 rs867398451 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003937-T02-IM5 Lung Adenocarcinoma P361L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.97 Missense_Mutation SNP diploid NA NA NA 19 10602496 10602496 G A 19:g.10602496G>A ENST00000171111.5:c.1082C>T 0.52 198 182 12 3/6 0.00000454364 rs750532889 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003937-T01-IM5 Lung Adenocarcinoma P361L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.97 Missense_Mutation SNP diploid NA NA NA 19 10602496 10602496 G A 19:g.10602496G>A ENST00000171111.5:c.1082C>T 0.33 101 201 13 3/6 0.00000454364 rs750532889 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005868-T02-IM5 Lung Adenocarcinoma P361L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.97 Missense_Mutation SNP diploid NA NA NA 19 10602496 10602496 G A 19:g.10602496G>A ENST00000171111.5:c.1082C>T 0.25 106 322 4 3/6 0.00000454364 rs750532889 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006175-T01-IM5 Lung Adenocarcinoma T112S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid NA NA NA 19 10610376 10610376 T A 19:g.10610376T>A ENST00000171111.5:c.334A>T 0.55 537 448 16 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000676-T01-IM3 Lung Adenocarcinoma E219K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.883 Missense_Mutation SNP diploid NA NA NA 19 10602923 10602923 C T 19:g.10602923C>T ENST00000171111.5:c.655G>A 0.33 160 326 9 3/6 rs370923924 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012001-T01-IM5 Lung Adenocarcinoma E219K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.883 Missense_Mutation SNP diploid NA NA NA 19 10602923 10602923 C T 19:g.10602923C>T ENST00000171111.5:c.655G>A 0.11 138 1067 9 3/6 rs370923924 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002033-T01-IM3 Lung Adenocarcinoma M156T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.76 Missense_Mutation SNP diploid 1 NA NA NA 19 10610243 10610243 A G 19:g.10610243A>G ENST00000171111.5:c.467T>C 0.13 149 983 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003964-T01-IM3 Lung Adenocarcinoma R6W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious_low_confidence, score: 0.02;Polyphen-2: impact: benign, score: 0.086 Missense_Mutation SNP diploid NA NA NA 19 10610694 10610694 T A 19:g.10610694T>A ENST00000171111.5:c.16A>T 0.36 55 98 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002060-T01-IM3 Lung Adenocarcinoma A392P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.2;Polyphen-2: impact: possibly_damaging, score: 0.837 Missense_Mutation SNP diploid NA NA NA 19 10602404 10602404 C G 19:g.10602404C>G ENST00000171111.5:c.1174G>C 0.18 102 452 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001550-T01-IM3 Lung Adenocarcinoma E25Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.34;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP diploid 1 NA NA NA 19 10610637 10610637 C G 19:g.10610637C>G ENST00000171111.5:c.73G>C 0.05 33 591 12 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000395-T01-IM3 Lung Adenocarcinoma V99M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10610415 10610415 C T 19:g.10610415C>T ENST00000171111.5:c.295G>A 0.42 395 551 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006308-T01-IM5 Cancer of Unknown Primary S431F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP diploid NA NA NA 19 10602286 10602286 G A 19:g.10602286G>A ENST00000171111.5:c.1292C>T 0.32 80 173 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007123-T01-IM5 Lung Adenocarcinoma S431F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP diploid NA NA NA 19 10602286 10602286 G A 19:g.10602286G>A ENST00000171111.5:c.1292C>T 0.21 158 580 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004709-T01-IM5 Lung Adenocarcinoma I416F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: benign, score: 0.051 Missense_Mutation SNP diploid NA NA NA 19 10602332 10602332 T A 19:g.10602332T>A ENST00000171111.5:c.1246A>T 0.46 220 260 7 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006133-T01-IM5 Lung Adenocarcinoma V606M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.981 Missense_Mutation SNP diploid NA NA NA 19 10597387 10597387 C T 19:g.10597387C>T ENST00000171111.5:c.1816G>A 0.05 39 683 58 6/6 0.000003977408320233783 rs150193881 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003505-T01-IM5 Lung Adenocarcinoma V168F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.985 Missense_Mutation SNP diploid NA NA NA 19 10610208 10610208 C A 19:g.10610208C>A ENST00000171111.5:c.502G>T 0.62 239 148 16 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007239-T01-IM5 Lung Adenocarcinoma G464V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid NA NA NA 19 10600464 10600464 C A 19:g.10600464C>A ENST00000171111.5:c.1391G>T 0.91 220 21 4 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002105-T01-IM3 Lung Adenocarcinoma W403C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602369 10602369 C A 19:g.10602369C>A ENST00000171111.5:c.1209G>T 0.75 241 80 34 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004315-T01-IM5 Lung Adenocarcinoma W403C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602369 10602369 C A 19:g.10602369C>A ENST00000171111.5:c.1209G>T 0.36 214 387 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006993-T01-IM5 Lung Adenocarcinoma L339F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid NA NA NA 19 10602563 10602563 G A 19:g.10602563G>A ENST00000171111.5:c.1015C>T 0.08 26 281 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009171-T01-IM5 Lung Adenocarcinoma E493K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.506 Missense_Mutation SNP diploid 1 NA NA NA 19 10600378 10600378 C T 19:g.10600378C>T ENST00000171111.5:c.1477G>A 0.31 332 728 21 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009426-T01-IM5 Lung Adenocarcinoma V568F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid NA NA NA 19 10599874 10599874 C A 19:g.10599874C>A ENST00000171111.5:c.1702G>T 0.31 59 131 10 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009277-T01-IM5 Lung Adenocarcinoma A510V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.24;Polyphen-2: impact: benign, score: 0.291 Missense_Mutation SNP diploid NA NA NA 19 10600326 10600326 G A 19:g.10600326G>A ENST00000171111.5:c.1529C>T 0.06 68 1057 2 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003129-T01-IM5 Lung Adenocarcinoma R413L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602340 10602340 C A 19:g.10602340C>A ENST00000171111.5:c.1238G>T 0.56 239 190 15 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008297-T01-IM5 Lung Adenocarcinoma R413L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602340 10602340 C A 19:g.10602340C>A ENST00000171111.5:c.1238G>T 0.17 145 693 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008944-T01-IM5 Lung Adenocarcinoma G511C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10600324 10600324 C A 19:g.10600324C>A ENST00000171111.5:c.1531G>T 0.21 120 448 11 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008851-T01-IM5 Non-Small Cell Lung Cancer G605R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10597390 10597390 C G 19:g.10597390C>G ENST00000171111.5:c.1813G>C 0.50 764 758 8 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007619-T01-IM5 Lung Adenocarcinoma H311Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.153 Missense_Mutation SNP diploid 2 NA NA NA 19 10602647 10602647 G A 19:g.10602647G>A ENST00000171111.5:c.931C>T 0.26 154 441 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008976-T01-IM5 Lung Adenocarcinoma E219S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.929 Missense_Mutation DNP diploid NA NA NA 19 10602922 10602923 TC GA 19:g.10602922_10602923delinsGA ENST00000171111.5:c.655_656inv 0.77 433 129 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005295-T01-IM5 Lung Adenocarcinoma W450R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10600507 10600507 A G 19:g.10600507A>G ENST00000171111.5:c.1348T>C 0.06 43 694 4 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001916-T01-IM3 Lung Adenocarcinoma D236V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.123 Missense_Mutation SNP diploid 4 NA NA NA 19 10602871 10602871 T A 19:g.10602871T>A ENST00000171111.5:c.707A>T 0.29 144 360 17 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005911-T01-IM5 Cancer of Unknown Primary D236V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.123 Missense_Mutation SNP diploid 4 NA NA NA 19 10602871 10602871 T A 19:g.10602871T>A ENST00000171111.5:c.707A>T 0.35 208 391 15 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004110-T01-IM5 Lung Adenocarcinoma M161I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.877 Missense_Mutation SNP diploid 1 NA NA NA 19 10610227 10610227 C A 19:g.10610227C>A ENST00000171111.5:c.483G>T 0.27 214 591 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004891-T01-IM5 Lung Adenocarcinoma M456K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP diploid NA NA NA 19 10600488 10600488 A T 19:g.10600488A>T ENST00000171111.5:c.1367T>A 0.31 116 260 11 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002850-T01-IM3 Lung Adenocarcinoma C273S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.815 Missense_Mutation SNP diploid NA NA NA 19 10602760 10602760 C G 19:g.10602760C>G ENST00000171111.5:c.818G>C 0.54 462 389 18 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002954-T01-IM3 Lung Adenocarcinoma M67I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: benign, score: 0.332 Missense_Mutation SNP diploid NA NA NA 19 10610509 10610509 C A 19:g.10610509C>A ENST00000171111.5:c.201G>T 0.23 117 402 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002412-T01-IM3 Lung Adenocarcinoma W252L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.879 Missense_Mutation SNP diploid 1 NA NA NA 19 10602823 10602823 C A 19:g.10602823C>A ENST00000171111.5:c.755G>T 0.42 195 269 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008406-T01-IM5 Lung Adenocarcinoma W252L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.879 Missense_Mutation SNP diploid 1 NA NA NA 19 10602823 10602823 C A 19:g.10602823C>A ENST00000171111.5:c.755G>T 0.54 367 317 25 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002639-T01-IM3 Lung Adenocarcinoma G195R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.934 Missense_Mutation SNP diploid 1 NA NA NA 19 10610127 10610127 C G 19:g.10610127C>G ENST00000171111.5:c.583G>C 0.15 121 697 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002905-T01-IM3 Lung Adenocarcinoma H96R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid 1 NA NA NA 19 10610423 10610423 T C 19:g.10610423T>C ENST00000171111.5:c.287A>G 0.48 186 198 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001867-T01-IM3 Colon Adenocarcinoma Q82P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.13;Polyphen-2: impact: benign, score: 0.212 Missense_Mutation SNP diploid NA NA NA 19 10610465 10610465 T G 19:g.10610465T>G ENST00000171111.5:c.245A>C 0.36 128 228 13 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000678-T01-IM3 Colon Adenocarcinoma C257Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.17;Polyphen-2: impact: benign, score: 0.369 Missense_Mutation SNP diploid NA NA NA 19 10602808 10602808 C T 19:g.10602808C>T ENST00000171111.5:c.770G>A 0.44 115 148 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007216-T01-IM5 Colorectal Adenocarcinoma F335V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.21;Polyphen-2: impact: benign, score: 0.013 Missense_Mutation SNP diploid NA NA NA 19 10602575 10602575 A C 19:g.10602575A>C ENST00000171111.5:c.1003T>G 0.05 43 789 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002359-T01-IM3 Lung Adenocarcinoma I187N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.993 Missense_Mutation SNP diploid NA NA NA 19 10610150 10610150 A T 19:g.10610150A>T ENST00000171111.5:c.560T>A 0.10 79 750 9 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000110-T01-IM3 Lung Adenocarcinoma N504S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.28;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP diploid NA NA NA 19 10600344 10600344 T C 19:g.10600344T>C ENST00000171111.5:c.1511A>G 0.15 125 688 15 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002766-T01-IM3 Lung Adenocarcinoma M161V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.824 Missense_Mutation SNP diploid 1 NA NA NA 19 10610229 10610229 T C 19:g.10610229T>C ENST00000171111.5:c.481A>G 0.13 102 654 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009833-T01-IM5 Lung Adenocarcinoma P130T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 NA NA NA 19 10610322 10610322 G T 19:g.10610322G>T ENST00000171111.5:c.388C>A 0.39 281 442 33 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000363-T01-IM3 Lung Squamous Cell Carcinoma S144Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.777 Missense_Mutation SNP diploid 1 NA NA NA 19 10610279 10610279 G T 19:g.10610279G>T ENST00000171111.5:c.431C>A 0.40 199 299 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002200-T01-IM3 Gallbladder Cancer V369A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.166 Missense_Mutation SNP diploid 1 NA NA NA 19 10602472 10602472 A G 19:g.10602472A>G ENST00000171111.5:c.1106T>C 0.45 368 448 11 3/6 0.0012347119274089616 Likely benign rs149721624 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002344-T01-IM3 Choriocarcinoma L153F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP diploid NA NA NA 19 10610253 10610253 G A 19:g.10610253G>A ENST00000171111.5:c.457C>T 0.41 177 252 18 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012247-T01-IM5 Head and Neck Squamous Cell Carcinoma L153F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP diploid NA NA NA 19 10610253 10610253 G A 19:g.10610253G>A ENST00000171111.5:c.457C>T 0.10 27 232 10 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002637-T01-IM3 Large Cell Neuroendocrine Carcinoma G332S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid NA NA NA 19 10602584 10602584 C T 19:g.10602584C>T ENST00000171111.5:c.994G>A 0.80 558 140 17 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005704-T01-IM5 Cancer of Unknown Primary A91T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.039 Missense_Mutation SNP diploid 1 NA NA NA 19 10610439 10610439 C T 19:g.10610439C>T ENST00000171111.5:c.271G>A 0.22 274 957 7 2/6 0.0002906444342475315 rs202181679 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007121-T01-IM5 Lung Adenocarcinoma C288F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.915 Missense_Mutation SNP diploid 1 NA NA NA 19 10602715 10602715 C A 19:g.10602715C>A ENST00000171111.5:c.863G>T 0.06 44 739 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011149-T01-IM5 Cancer of Unknown Primary G462W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10600471 10600471 C A 19:g.10600471C>A ENST00000171111.5:c.1384G>T 0.32 208 450 12 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010840-T02-IM5 Lung Adenocarcinoma A191P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 2 NA NA NA 19 10610139 10610139 C G 19:g.10610139C>G ENST00000171111.5:c.571G>C 0.65 207 113 11 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001248-T01-IM3 Uterine Endometrioid Carcinoma Y33C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: benign, score: 0.109 Missense_Mutation SNP diploid NA NA NA 19 10610612 10610612 T C 19:g.10610612T>C ENST00000171111.5:c.98A>G 0.21 99 374 31 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005790-T01-IM5 Breast Invasive Ductal Carcinoma Y334dup OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Ins INS diploid NA NA NA 19 10602574 10602575 - AGT 19:g.10602574_10602575insAGT ENST00000171111.5:c.1001_1003dup 0.16 50 268 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006368-T01-IM5 Lung Squamous Cell Carcinoma R296C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.543 Missense_Mutation SNP diploid NA NA NA 19 10602692 10602692 G A 19:g.10602692G>A ENST00000171111.5:c.886C>T 0.20 415 1693 63 3/6 rs1278385562 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009316-T01-IM5 Uterine Endometrioid Carcinoma R296C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.543 Missense_Mutation SNP diploid NA NA NA 19 10602692 10602692 G A 19:g.10602692G>A ENST00000171111.5:c.886C>T 0.22 173 620 11 3/6 rs1278385562 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009405-T01-IM5 Invasive Breast Carcinoma T314_P322del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid NA NA NA 19 10602611 10602637 TGGGCGCCCGGCAGGGCATCACCTGCG - 19:g.10602611_10602637del ENST00000171111.5:c.941_967del 0.33 289 574 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009585-T01-IM5 Uterine Endometrioid Carcinoma A321V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: benign, score: 0.015 Missense_Mutation SNP diploid NA NA NA 19 10602616 10602616 G A 19:g.10602616G>A ENST00000171111.5:c.962C>T 0.20 53 209 35 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003503-T01-IM5 Extrahepatic Cholangiocarcinoma N68S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.284 Missense_Mutation SNP diploid NA NA NA 19 10610507 10610507 T C 19:g.10610507T>C ENST00000171111.5:c.203A>G 0.75 58 19 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004688-T01-IM5 Upper Tract Urothelial Carcinoma G433S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.862 Missense_Mutation SNP diploid NA NA NA 19 10602281 10602281 C T 19:g.10602281C>T ENST00000171111.5:c.1297G>A 0.13 110 717 413 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009152-T01-IM5 Bladder Urothelial Carcinoma G433S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.862 Missense_Mutation SNP diploid NA NA NA 19 10602281 10602281 C T 19:g.10602281C>T ENST00000171111.5:c.1297G>A 0.32 273 569 60 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005783-T01-IM5 Cancer of Unknown Primary A91S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.54;Polyphen-2: impact: benign, score: 0.226 Missense_Mutation SNP diploid 1 NA NA NA 19 10610439 10610439 C A 19:g.10610439C>A ENST00000171111.5:c.271G>T 0.64 957 532 67 2/6 rs202181679 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009336-T01-IM5 Cancer of Unknown Primary A63D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.968 Missense_Mutation SNP diploid 2 NA NA NA 19 10610522 10610522 G T 19:g.10610522G>T ENST00000171111.5:c.188C>A 0.13 35 245 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009358-T01-IM5 Lung Adenocarcinoma V83F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.986 Missense_Mutation SNP diploid NA NA NA 19 10610463 10610463 C A 19:g.10610463C>A ENST00000171111.5:c.247G>T 0.57 312 234 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010744-T01-IM5 Anaplastic Oligodendroglioma D579N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.21;Polyphen-2: impact: possibly_damaging, score: 0.459 Missense_Mutation SNP diploid 1 NA NA NA 19 10597468 10597468 C T 19:g.10597468C>T ENST00000171111.5:c.1735G>A 0.08 65 744 102 6/6 0.000015955452374932367 rs372588031 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011453-T01-IM5 Lung Adenocarcinoma N183H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid NA NA NA 19 10610163 10610163 T G 19:g.10610163T>G ENST00000171111.5:c.547A>C 0.10 87 770 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003666-T01-IM5 Lung Adenocarcinoma A321_P322delinsPS OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA Missense_Mutation ONP diploid NA NA NA 19 10602614 10602617 GCGC ACGG 19:g.10602614_10602617delinsACGG ENST00000171111.5:c.961_964delinsCCGT 0.44 250 322 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000083-T01-IM3 Bladder Urothelial Carcinoma E542N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.88;Polyphen-2: impact: benign, score: 0 Missense_Mutation TNP diploid NA NA NA 19 10599950 10599952 CTC GTT 19:g.10599950_10599952delinsGTT ENST00000171111.5:c.1624_1626delinsAAC 0.20 173 674 116 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000325-T01-IM3 Anal Squamous Cell Carcinoma C368Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.983 Missense_Mutation SNP diploid 1 NA NA NA 19 10602475 10602475 C T 19:g.10602475C>T ENST00000171111.5:c.1103G>A 0.55 139 113 3 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000729-T01-IM3 Lung Squamous Cell Carcinoma C368F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.975 Missense_Mutation SNP diploid 1 NA NA NA 19 10602475 10602475 C A 19:g.10602475C>A ENST00000171111.5:c.1103G>T 0.23 152 495 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0000944-T01-IM3 Glioblastoma Multiforme A321T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 1;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid NA NA NA 19 10602617 10602617 C T 19:g.10602617C>T ENST00000171111.5:c.961G>A 0.06 27 424 111 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001084-T01-IM3 Lung Squamous Cell Carcinoma R362P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.812 Missense_Mutation SNP diploid 1 NA NA NA 19 10602493 10602493 C G 19:g.10602493C>G ENST00000171111.5:c.1085G>C 0.33 140 278 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001209-T01-IM3 Cancer of Unknown Primary V98G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.952 Missense_Mutation SNP diploid NA NA NA 19 10610417 10610417 A C 19:g.10610417A>C ENST00000171111.5:c.293T>G 0.19 127 543 17 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0001127-T02-IM3 Lung Squamous Cell Carcinoma E493A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.511 Missense_Mutation SNP diploid 1 NA NA NA 19 10600377 10600377 T G 19:g.10600377T>G ENST00000171111.5:c.1478A>C 0.35 241 455 3 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002075-T01-IM3 Lung Adenocarcinoma P492S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.97 Missense_Mutation SNP diploid NA NA NA 19 10600381 10600381 G A 19:g.10600381G>A ENST00000171111.5:c.1474C>T 0.29 230 572 33 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002087-T01-IM3 Cancer of Unknown Primary R269L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.64;Polyphen-2: impact: benign, score: 0.07 Missense_Mutation SNP diploid 1 NA NA NA 19 10602772 10602772 C A 19:g.10602772C>A ENST00000171111.5:c.806G>T 0.06 39 648 20 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002862-T01-IM3 Glioblastoma Multiforme K254R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.65;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid 1 NA NA NA 19 10602817 10602817 T C 19:g.10602817T>C ENST00000171111.5:c.761A>G 0.27 415 1134 4 3/6 0.000023885920832975652 rs374203165 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003734-T01-IM5 Lung Adenocarcinoma Q563R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: benign, score: 0.244 Missense_Mutation SNP diploid 1 NA NA NA 19 10599888 10599888 T C 19:g.10599888T>C ENST00000171111.5:c.1688A>G 0.06 38 596 20 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003734-T01-IM5 Lung Adenocarcinoma G378C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602446 10602446 C A 19:g.10602446C>A ENST00000171111.5:c.1132G>T 0.08 32 373 20 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010612-T01-IM5 Lung Adenocarcinoma G378C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602446 10602446 C A 19:g.10602446C>A ENST00000171111.5:c.1132G>T 0.57 582 434 26 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0003838-T02-IM5 Renal Clear Cell Carcinoma F211L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid NA NA NA 19 10610077 10610077 A C 19:g.10610077A>C ENST00000171111.5:c.633T>G 0.23 103 345 7 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004074-T01-IM5 Lung Adenocarcinoma A427D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.96 Missense_Mutation SNP diploid NA NA NA 19 10602298 10602298 G T 19:g.10602298G>T ENST00000171111.5:c.1280C>A 0.14 39 232 14 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004183-T01-IM5 Breast Invasive Ductal Carcinoma L153dup OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Ins INS diploid NA NA NA 19 10610249 10610250 - GGA 19:g.10610249_10610250insGGA ENST00000171111.5:c.458_460dup 0.32 179 382 3 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004281-T01-IM5 Papillary Renal Cell Carcinoma R135L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.528 Missense_Mutation SNP diploid NA NA NA 19 10610306 10610306 C A 19:g.10610306C>A ENST00000171111.5:c.404G>T 0.05 33 589 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004503-T01-IM5 Anaplastic Thyroid Cancer D389G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 NA NA NA 19 10602412 10602412 T C 19:g.10602412T>C ENST00000171111.5:c.1166A>G 0.68 391 183 4 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004863-T01-IM5 Lung Adenocarcinoma Q528P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.24;Polyphen-2: impact: benign, score: 0.106 Missense_Mutation SNP diploid NA NA NA 19 10599993 10599993 T G 19:g.10599993T>G ENST00000171111.5:c.1583A>C 0.11 93 758 40 5/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005543-T02-IM5 Lung Adenocarcinoma N157K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: possibly_damaging, score: 0.649 Missense_Mutation SNP diploid NA NA NA 19 10610239 10610239 G T 19:g.10610239G>T ENST00000171111.5:c.471C>A 0.15 127 693 12 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0005827-T01-IM5 Lung Adenosquamous Carcinoma M399I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.04 Missense_Mutation SNP diploid NA NA NA 19 10602381 10602381 C T 19:g.10602381C>T ENST00000171111.5:c.1197G>A 0.11 105 814 20 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012084-T01-IM5 Lung Squamous Cell Carcinoma M399I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.04 Missense_Mutation SNP diploid NA NA NA 19 10602381 10602381 C T 19:g.10602381C>T ENST00000171111.5:c.1197G>A 0.44 338 438 16 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0006368-T01-IM5 Lung Squamous Cell Carcinoma T277M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.727 Missense_Mutation SNP diploid NA NA NA 19 10602748 10602748 G A 19:g.10602748G>A ENST00000171111.5:c.830C>T 0.37 770 1308 63 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007074-T01-IM5 Lung Adenocarcinoma N414I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.988 Missense_Mutation SNP diploid NA NA NA 19 10602337 10602337 T A 19:g.10602337T>A ENST00000171111.5:c.1241A>T 0.22 148 513 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007277-T01-IM5 Cutaneous Squamous Cell Carcinoma A474V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.28;Polyphen-2: impact: benign, score: 0.25 Missense_Mutation SNP diploid NA NA NA 19 10600434 10600434 G A 19:g.10600434G>A ENST00000171111.5:c.1421C>T 0.08 68 805 54 4/6 rs867169234 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007776-T01-IM5 Lung Adenocarcinoma E205V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.18;Polyphen-2: impact: possibly_damaging, score: 0.777 Missense_Mutation SNP diploid NA NA NA 19 10610096 10610096 T A 19:g.10610096T>A ENST00000171111.5:c.614A>T 0.06 62 944 6 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008000-T01-IM5 Small Cell Lung Cancer S555C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.918 Missense_Mutation SNP diploid 1 NA NA NA 19 10599913 10599913 T A 19:g.10599913T>A ENST00000171111.5:c.1663A>T 0.11 82 661 5 5/6 0.0000318959 rs1245862456 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008046-T01-IM5 Lung Adenocarcinoma M610I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.26;Polyphen-2: impact: benign, score: 0.017 Missense_Mutation SNP diploid NA NA NA 19 10597373 10597373 C T 19:g.10597373C>T ENST00000171111.5:c.1830G>A 0.11 104 851 7 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0004733-T02-IM5 Poorly Differentiated Non-Small Cell Lung Cancer W403L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid NA NA NA 19 10602370 10602370 C A 19:g.10602370C>A ENST00000171111.5:c.1208G>T 0.63 409 240 25 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008675-T01-IM5 Lung Squamous Cell Carcinoma I304N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: benign, score: 0.284 Missense_Mutation SNP diploid 1 NA NA NA 19 10602667 10602667 A T 19:g.10602667A>T ENST00000171111.5:c.911T>A 0.73 524 191 21 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008775-T01-IM5 Papillary Renal Cell Carcinoma A331P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid NA NA NA 19 10602587 10602587 C G 19:g.10602587C>G ENST00000171111.5:c.991G>C 0.36 196 341 5 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0008796-T01-IM5 Non-Small Cell Lung Cancer I125F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.933 Missense_Mutation SNP diploid 1 NA NA NA 19 10610337 10610337 T A 19:g.10610337T>A ENST00000171111.5:c.373A>T 0.31 356 777 61 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009590-T02-IM5 Lung Adenocarcinoma D236Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.551 Missense_Mutation SNP diploid 4 NA NA NA 19 10602872 10602872 C A 19:g.10602872C>A ENST00000171111.5:c.706G>T 0.15 116 676 8 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009622-T01-IM5 Cancer of Unknown Primary T51S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid NA NA NA 19 10610558 10610558 G C 19:g.10610558G>C ENST00000171111.5:c.152C>G 0.44 457 591 15 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009857-T01-IM5 Lung Squamous Cell Carcinoma Y584C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 2 NA NA NA 19 10597452 10597452 T C 19:g.10597452T>C ENST00000171111.5:c.1751A>G 0.18 167 775 7 6/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0009894-T01-IM5 Lung Adenocarcinoma D294V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.005 Missense_Mutation SNP diploid NA NA NA 19 10602697 10602697 T A 19:g.10602697T>A ENST00000171111.5:c.881A>T 0.19 164 703 10 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010030-T01-IM5 Lung Adenocarcinoma Y263_V264delinsF OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid NA NA NA 19 10602788 10602790 CGT - 19:g.10602788_10602790del ENST00000171111.5:c.788_790del 0.72 492 192 11 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010231-T01-IM5 Lung Adenocarcinoma H274L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP diploid NA NA NA 19 10602757 10602757 T A 19:g.10602757T>A ENST00000171111.5:c.821A>T 0.28 148 379 6 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010397-T01-IM5 Lung Adenocarcinoma G419V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP diploid 1 NA NA NA 19 10602322 10602322 C A 19:g.10602322C>A ENST00000171111.5:c.1256G>T 0.53 895 796 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010557-T01-IM5 Lung Squamous Cell Carcinoma E149Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP diploid NA NA NA 19 10610265 10610265 C G 19:g.10610265C>G ENST00000171111.5:c.445G>C 0.52 393 357 5 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010569-T01-IM5 Cancer of Unknown Primary N238D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.741 Missense_Mutation SNP diploid NA NA NA 19 10602866 10602866 T C 19:g.10602866T>C ENST00000171111.5:c.712A>G 0.51 254 241 24 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010632-T01-IM5 Lung Adenocarcinoma I207S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.986 Missense_Mutation SNP diploid NA NA NA 19 10610090 10610090 A C 19:g.10610090A>C ENST00000171111.5:c.620T>G 0.16 100 508 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010632-T01-IM5 Lung Adenocarcinoma R204G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.826 Missense_Mutation SNP diploid 1 NA NA NA 19 10610100 10610100 G C 19:g.10610100G>C ENST00000171111.5:c.610C>G 0.17 111 529 8 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010649-T01-IM5 Cutaneous Squamous Cell Carcinoma F52L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 1;Polyphen-2: impact: benign, score: 0.015 Missense_Mutation SNP diploid NA NA NA 19 10610554 10610554 G T 19:g.10610554G>T ENST00000171111.5:c.156C>A 0.20 174 711 104 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0002265-T02-IM5 Glioblastoma Multiforme G48D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.939 Missense_Mutation SNP diploid NA NA NA 19 10610567 10610567 C T 19:g.10610567C>T ENST00000171111.5:c.143G>A 0.16 124 665 147 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010820-T01-IM5 Hurthle Cell Thyroid Cancer R483S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.972 Missense_Mutation SNP diploid 2 NA NA NA 19 10600408 10600408 G T 19:g.10600408G>T ENST00000171111.5:c.1447C>A 0.48 488 537 4 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0010980-T01-IM5 Lung Adenocarcinoma L281M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.975 Missense_Mutation SNP diploid NA NA NA 19 10602737 10602737 G T 19:g.10602737G>T ENST00000171111.5:c.841C>A 0.20 185 727 9 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011017-T01-IM5 Lung Squamous Cell Carcinoma G127A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.9 Missense_Mutation SNP diploid NA NA NA 19 10610330 10610330 C G 19:g.10610330C>G ENST00000171111.5:c.380G>C 0.27 277 747 4 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011198-T01-IM5 Prostate Adenocarcinoma T314M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.001 Missense_Mutation SNP diploid NA NA NA 19 10602637 10602637 G A 19:g.10602637G>A ENST00000171111.5:c.941C>T 0.07 53 682 1 3/6 rs777523734 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011333-T01-IM5 Lung Adenocarcinoma T142A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 2 NA NA NA 19 10610286 10610286 T C 19:g.10610286T>C ENST00000171111.5:c.424A>G 0.28 198 503 20 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011432-T01-IM5 Head and Neck Squamous Cell Carcinoma of Unknown Primary G127D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.37;Polyphen-2: impact: benign, score: 0.193 Missense_Mutation SNP diploid NA NA NA 19 10610330 10610330 C T 19:g.10610330C>T ENST00000171111.5:c.380G>A 0.35 283 518 55 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0011569-T01-IM5 Uterine Endometrioid Carcinoma T330I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.43;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid NA NA NA 19 10602589 10602589 G A 19:g.10602589G>A ENST00000171111.5:c.989C>T 0.05 38 662 47 3/6 0.00000401397 rs1378587016 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012084-T01-IM5 Lung Squamous Cell Carcinoma E493Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.268 Missense_Mutation SNP diploid 1 NA NA NA 19 10600378 10600378 C G 19:g.10600378C>G ENST00000171111.5:c.1477G>C 0.43 374 492 16 4/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012082-T01-IM5 Lung Adenocarcinoma L353P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.08;Polyphen-2: impact: possibly_damaging, score: 0.905 Missense_Mutation SNP diploid NA NA NA 19 10602520 10602520 A G 19:g.10602520A>G ENST00000171111.5:c.1058T>C 0.77 328 97 39 3/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012113-T01-IM5 Uterine Endometrioid Carcinoma G212E OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.61;Polyphen-2: impact: benign, score: 0.012 Missense_Mutation SNP diploid NA NA NA 19 10610075 10610075 C T 19:g.10610075C>T ENST00000171111.5:c.635G>A 0.18 169 777 244 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012358-T01-IM5 Uterine Endometrioid Carcinoma E496K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.34;Polyphen-2: impact: benign, score: 0.081 Missense_Mutation SNP diploid NA NA NA 19 10600369 10600369 C T 19:g.10600369C>T ENST00000171111.5:c.1486G>A 0.28 117 306 455 4/6 0.00005964641603812146 rs549967865 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0012557-T01-IM5 Bladder Urothelial Carcinoma F211I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid NA NA NA 19 10610079 10610079 A T 19:g.10610079A>T ENST00000171111.5:c.631T>A 0.09 19 201 15 2/6 MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017) P-0007052-T01-IM5 Upper Tract Urothelial Carcinoma E244Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.625 Missense_Mutation SNP diploid 1 NA NA NA 19 10602848 10602848 C G 19:g.10602848C>G ENST00000171111.5:c.730G>C 0.32 176 373 58 3/6 Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccRCC_46 Renal Clear Cell Carcinoma with Sarcomatoid Features D579Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.938 Missense_Mutation SNP 1 NA NA UTokyo 19 10597468 10597468 C A 19:g.10597468C>A ENST00000171111.5:c.1735G>T 75 6/6 Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccRCC_51 Renal Clear Cell Carcinoma with Sarcomatoid Features K254T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.022 Missense_Mutation SNP 1 NA NA UTokyo 19 10602817 10602817 T G 19:g.10602817T>G ENST00000171111.5:c.761A>C 63 3/6 Glioma (MSK, Nature 2019) Patient-36-T2 Glioblastoma Multiforme E542K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: benign, score: 0.056 Missense_Mutation SNP diploid SOMATIC NA MSK-IMPACT410 19 10599952 10599952 C T 19:g.10599952C>T ENST00000171111.5:c.1624G>A 0.06 43 682 528 112 5/6 Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-5P-A9KE-01 Papillary Renal Cell Carcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP diploid 1 . . . 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 0.27 12 33 52 74 3/6 Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-HE-7129-01 Papillary Renal Cell Carcinoma P278Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 2 . . . 19 10602745 10602745 G T 19:g.10602745G>T ENST00000171111.5:c.833C>A 0.08 6 73 111 431 3/6 Metastatic Melanoma (DFCI, Nature Medicine 2019) Sample49 Melanoma E205K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.29;Polyphen-2: impact: benign, score: 0.284 Missense_Mutation SNP diploid NA NA NA 19 10610097 10610097 C T 19:g.10610097C>T ENST00000171111.5:c.613G>A 1602 2/6 Metastatic Melanoma (DFCI, Nature Medicine 2019) Sample6 Melanoma M597I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.232 Missense_Mutation SNP shallowdel NA NA NA 19 10597412 10597412 C T 19:g.10597412C>T ENST00000171111.5:c.1791G>A 926 6/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-AEIUF Lung Adenocarcinoma V316_M317del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL shallowdel Unknown NA broad.mit.edu 19 10602627 10602632 CATCAC - 19:g.10602627_10602632del ENST00000171111.5:c.946_951del 207 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-NYU1051S Lung Adenocarcinoma G603W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10597396 10597396 C A 19:g.10597396C>A ENST00000171111.5:c.1807G>T 482 6/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01700 Lung Adenocarcinoma R71L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 Unknown NA broad.mit.edu 19 10610498 10610498 C A 19:g.10610498C>A ENST00000171111.5:c.212G>T 196 2/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01721 Lung Adenocarcinoma Y141F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP shallowdel 2 Unknown NA broad.mit.edu 19 10610288 10610288 T A 19:g.10610288T>A ENST00000171111.5:c.422A>T 366 2/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01840 Lung Adenocarcinoma E611D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.101 Missense_Mutation SNP diploid 1 Unknown NA broad.mit.edu 19 10597370 10597370 C G 19:g.10597370C>G ENST00000171111.5:c.1833G>C 126 6/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-S01306 Lung Adenocarcinoma N397del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid 1 Unknown NA broad.mit.edu 19 10602387 10602389 GTT - 19:g.10602387_10602389del ENST00000171111.5:c.1189_1191del 368 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-S01381 Lung Adenocarcinoma H96L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel 1 Unknown NA broad.mit.edu 19 10610423 10610423 T A 19:g.10610423T>A ENST00000171111.5:c.287A>T 209 2/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-S01404 Lung Adenocarcinoma D389Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 Unknown NA broad.mit.edu 19 10602413 10602413 C A 19:g.10602413C>A ENST00000171111.5:c.1165G>T 201 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-YINHD Lung Adenocarcinoma G419W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 Unknown NA broad.mit.edu 19 10602323 10602323 C A 19:g.10602323C>A ENST00000171111.5:c.1255G>T 2733 3/6 Lung Adenocarcinoma (Broad, Cell 2012) LUAD-RT-S01487 Lung Adenocarcinoma P278R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 2 Unknown NA broad.mit.edu 19 10602745 10602745 G C 19:g.10602745G>C ENST00000171111.5:c.833C>G 160 3/6 Colorectal Adenocarcinoma (Genentech, Nature 2012) 587228 Colorectal Adenocarcinoma T142M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 2 NA VALIDATED Genentech 19 10610285 10610285 G A 19:g.10610285G>A ENST00000171111.5:c.425C>T 1292 2/6 Colorectal Adenocarcinoma (Genentech, Nature 2012) 587226 Colorectal Adenocarcinoma A191D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.992 Missense_Mutation SNP 2 NA VALIDATED Genentech 19 10610138 10610138 G T 19:g.10610138G>T ENST00000171111.5:c.572C>A 802 2/6 Metastatic Breast Cancer (INSERM, PLoS Med 2016) MBC_108 Invasive Breast Carcinoma C613F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid Somatic NA GR 19 10597365 10597365 C A 19:g.10597365C>A ENST00000171111.5:c.1838G>T 0.28 7 18 11 26 6/6 Metastatic Breast Cancer (INSERM, PLoS Med 2016) MBC_31 Invasive Breast Carcinoma G158R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.914 Missense_Mutation SNP gain Somatic NA GR 19 10610238 10610238 C G 19:g.10610238C>G ENST00000171111.5:c.472G>C 0.51 124 121 281 307 2/6 Metastatic Breast Cancer (INSERM, PLoS Med 2016) MBC_196 Invasive Breast Carcinoma E242A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.763 Missense_Mutation SNP diploid Somatic NA GR 19 10602853 10602853 T G 19:g.10602853T>G ENST00000171111.5:c.725A>C 0.13 26 174 224 41 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-39-5034-01 Lung Squamous Cell Carcinoma R554Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10599915 10599915 C T 19:g.10599915C>T ENST00000171111.5:c.1661G>A 0.57 29 22 64 539 5/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-O2-A52Q-01 Lung Squamous Cell Carcinoma R554Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10599915 10599915 C T 19:g.10599915C>T ENST00000171111.5:c.1661G>A 0.41 9 13 40 887 5/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-77-7338-01 Lung Squamous Cell Carcinoma S103Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.961 Missense_Mutation SNP shallowdel . . . 19 10610402 10610402 G T 19:g.10610402G>T ENST00000171111.5:c.308C>A 0.27 13 35 126 118 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-37-4132-01 Lung Squamous Cell Carcinoma R71L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10610498 10610498 C A 19:g.10610498C>A ENST00000171111.5:c.212G>T 0.48 80 87 214 272 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-85-8354-01 Lung Squamous Cell Carcinoma E117K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel 1 . . . 19 10610361 10610361 C T 19:g.10610361C>T ENST00000171111.5:c.349G>A 0.55 22 18 62 184 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-4538-01 Lung Squamous Cell Carcinoma L310P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.915 Missense_Mutation SNP gain 1 . . . 19 10602649 10602649 A G 19:g.10602649A>G ENST00000171111.5:c.929T>C 0.36 49 88 168 170 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-43-6143-01 Lung Squamous Cell Carcinoma I506V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP shallowdel 1 . . . 19 10600339 10600339 T C 19:g.10600339T>C ENST00000171111.5:c.1516A>G 0.89 41 5 57 299 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-51-4081-01 Lung Squamous Cell Carcinoma V418L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP shallowdel 2 . . . 19 10602326 10602326 C A 19:g.10602326C>A ENST00000171111.5:c.1252G>T 0.31 14 31 35 185 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-60-2723-01 Lung Squamous Cell Carcinoma L231V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.132 Missense_Mutation SNP shallowdel 1 . . . 19 10602887 10602887 G C 19:g.10602887G>C ENST00000171111.5:c.691C>G 0.38 32 52 71 262 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-66-2754-01 Lung Squamous Cell Carcinoma W544C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10599944 10599944 C A 19:g.10599944C>A ENST00000171111.5:c.1632G>T 0.89 34 4 31 321 5/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-66-2756-01 Lung Squamous Cell Carcinoma V369L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.36;Polyphen-2: impact: benign, score: 0.029 Missense_Mutation SNP shallowdel 1 . . . 19 10602473 10602473 C G 19:g.10602473C>G ENST00000171111.5:c.1105G>C 0.80 8 2 11 474 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-66-2777-01 Lung Squamous Cell Carcinoma S224Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP shallowdel 1 . . . 19 10602907 10602907 G T 19:g.10602907G>T ENST00000171111.5:c.671C>A 0.30 27 62 159 150 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-56-A62T-01 Lung Squamous Cell Carcinoma E493V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.743 Missense_Mutation SNP shallowdel 1 . . . 19 10600377 10600377 T A 19:g.10600377T>A ENST00000171111.5:c.1478A>T 0.55 0.01 36 29 1 94 454 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-33-6738-01 Lung Squamous Cell Carcinoma R362Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.86 Missense_Mutation SNP shallowdel 1 . . . 19 10602493 10602493 C T 19:g.10602493C>T ENST00000171111.5:c.1085G>A 0.30 3 7 24 305 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-37-A5EN-01 Lung Squamous Cell Carcinoma D235Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.983 Missense_Mutation SNP shallowdel . . . 19 10602875 10602875 C A 19:g.10602875C>A ENST00000171111.5:c.703G>T 0.09 7 68 83 207 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-77-8009-01 Lung Squamous Cell Carcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP amp 1 . . . 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 0.80 267 66 85 156 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-56-7730-01 Lung Squamous Cell Carcinoma D589_T590del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL shallowdel . . . 19 10597434 10597439 GTGTCT - 19:g.10597434_10597439del ENST00000171111.5:c.1764_1769del 0.21 25 96 102 344 6/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-56-7730-01 Lung Squamous Cell Carcinoma C171F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10610198 10610198 C A 19:g.10610198C>A ENST00000171111.5:c.512G>T 0.38 19 31 59 344 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-56-8504-01 Lung Squamous Cell Carcinoma R234W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP diploid . . . 19 10602878 10602878 G A 19:g.10602878G>A ENST00000171111.5:c.700C>T 0.21 11 41 84 216 3/6 Uncertain significance rs1599484704 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-58-A46M-01 Lung Squamous Cell Carcinoma N482_R483delinsS OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL shallowdel . . . 19 10600408 10600410 GGT - 19:g.10600408_10600410del ENST00000171111.5:c.1445_1447del 0.53 26 23 60 357 4/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-63-A5M9-01 Lung Squamous Cell Carcinoma H274R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.393 Missense_Mutation SNP gain . . . 19 10602757 10602757 T C 19:g.10602757T>C ENST00000171111.5:c.821A>G 0.73 81 30 99 95 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-77-6845-01 Lung Squamous Cell Carcinoma T314K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0.011 Missense_Mutation SNP shallowdel . . . 19 10602637 10602637 G T 19:g.10602637G>T ENST00000171111.5:c.941C>A 0.69 25 11 49 229 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-77-8153-01 Lung Squamous Cell Carcinoma Q163K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid . . . 19 10610223 10610223 G T 19:g.10610223G>T ENST00000171111.5:c.487C>A 0.39 35 55 101 151 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-85-7698-01 Lung Squamous Cell Carcinoma P612L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid . . . 19 10597368 10597368 G A 19:g.10597368G>A ENST00000171111.5:c.1835C>T 0.19 35 145 228 122 6/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-85-8070-01 Lung Squamous Cell Carcinoma R135H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP shallowdel . . . 19 10610306 10610306 C T 19:g.10610306C>T ENST00000171111.5:c.404G>A 0.96 22 1 43 221 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-XC-AA0X-01 Lung Squamous Cell Carcinoma R135H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP shallowdel . . . 19 10610306 10610306 C T 19:g.10610306C>T ENST00000171111.5:c.404G>A 0.20 5 20 36 161 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-90-7964-01 Lung Squamous Cell Carcinoma H59R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.963 Missense_Mutation SNP shallowdel . . . 19 10610534 10610534 T C 19:g.10610534T>C ENST00000171111.5:c.176A>G 0.44 49 62 163 424 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-92-8063-01 Lung Squamous Cell Carcinoma W591L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10597431 10597431 C A 19:g.10597431C>A ENST00000171111.5:c.1772G>T 0.36 27 47 105 351 6/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-94-8490-01 Lung Squamous Cell Carcinoma L115Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.979 Missense_Mutation SNP diploid . . . 19 10610366 10610366 A T 19:g.10610366A>T ENST00000171111.5:c.344T>A 0.30 39 89 63 829 2/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-MF-A522-01 Lung Squamous Cell Carcinoma F220L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: benign, score: 0.066 Missense_Mutation SNP shallowdel . . . 19 10602918 10602918 G T 19:g.10602918G>T ENST00000171111.5:c.660C>A 0.75 86 29 37 471 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-85-6561-01 Lung Squamous Cell Carcinoma H274Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.51;Polyphen-2: impact: benign, score: 0.393 Missense_Mutation SNP gain . . . 19 10602756 10602756 G T 19:g.10602756G>T ENST00000171111.5:c.822C>A 0.08 3 34 102 1128 3/6 Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-92-7340-01 Lung Squamous Cell Carcinoma E307K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.027 Missense_Mutation SNP gain . . . 19 10602659 10602659 C T 19:g.10602659C>T ENST00000171111.5:c.919G>A 0.28 19 49 50 375 3/6 Stomach Adenocarcinoma (U Tokyo, Nat Genet 2014) GC_353T-GC_353N Stomach Adenocarcinoma D587G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.21;Polyphen-2: impact: benign, score: 0.001 Missense_Mutation SNP NA NA UTokyo 19 10597443 10597443 T C 19:g.10597443T>C ENST00000171111.5:c.1760A>G 0.17 9 43 145 6/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0008-R1 Non-Small Cell Lung Cancer S224F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP 1 NA NA NA 19 10602907 10602907 G A 19:g.10602907G>A ENST00000171111.5:c.671C>T 0.39 135 210 102 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0008-R2 Non-Small Cell Lung Cancer S224F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP 1 NA NA NA 19 10602907 10602907 G A 19:g.10602907G>A ENST00000171111.5:c.671C>T 0.28 110 284 148 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0008-Pre-ctDNA Non-Small Cell Lung Cancer S224F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP 1 NA NA NA 19 10602907 10602907 G A 19:g.10602907G>A ENST00000171111.5:c.671C>T 18 3/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0020-R1 Non-Small Cell Lung Cancer S555I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP 1 NA NA NA 19 10599912 10599912 C A 19:g.10599912C>A ENST00000171111.5:c.1664G>T 0.27 36 95 1425 5/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0020-R2 Non-Small Cell Lung Cancer S555I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP 1 NA NA NA 19 10599912 10599912 C A 19:g.10599912C>A ENST00000171111.5:c.1664G>T 0.17 17 81 1252 5/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0020-Pre-ctDNA Non-Small Cell Lung Cancer S555I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP 1 NA NA NA 19 10599912 10599912 C A 19:g.10599912C>A ENST00000171111.5:c.1664G>T 20 5/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0033-R1 Non-Small Cell Lung Cancer F107I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610391 10610391 A T 19:g.10610391A>T ENST00000171111.5:c.319T>A 0.36 341 601 29 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0033-R2 Non-Small Cell Lung Cancer F107I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610391 10610391 A T 19:g.10610391A>T ENST00000171111.5:c.319T>A 0.57 374 280 32 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0033-Pre-ctDNA Non-Small Cell Lung Cancer F107I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610391 10610391 A T 19:g.10610391A>T ENST00000171111.5:c.319T>A 11 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0006-R1 Non-Small Cell Lung Cancer C77G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610481 10610481 A C 19:g.10610481A>C ENST00000171111.5:c.229T>G 0.10 67 577 702 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0006-R2 Non-Small Cell Lung Cancer C77G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610481 10610481 A C 19:g.10610481A>C ENST00000171111.5:c.229T>G 0.13 68 473 718 2/6 Non-Small Cell Lung Cancer (TRACERx, NEJM & Nature 2017) CRUK0006-Pre-ctDNA Non-Small Cell Lung Cancer C77G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA NA 19 10610481 10610481 A C 19:g.10610481A>C ENST00000171111.5:c.229T>G 18 2/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-ZF-AA4N-01 Bladder Urothelial Carcinoma D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP diploid 4 . . . 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 0.41 27 39 50 152 3/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-GU-A42Q-01 Bladder Urothelial Carcinoma S45F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP shallowdel 3 . . . 19 10610576 10610576 G A 19:g.10610576G>A ENST00000171111.5:c.134C>T 0.36 28 49 86 166 2/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-DK-A1A3-01 Bladder Urothelial Carcinoma E25K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.06;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP gain 1 . . . 19 10610637 10610637 C T 19:g.10610637C>T ENST00000171111.5:c.73G>A 0.20 19 78 77 566 2/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-G2-A2EJ-01 Bladder Urothelial Carcinoma E218Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.812 Missense_Mutation SNP diploid 4 . . . 19 10602926 10602926 C G 19:g.10602926C>G ENST00000171111.5:c.652G>C 0.18 4 18 57 537 3/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-G2-A3IE-01 Bladder Urothelial Carcinoma E244K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.774 Missense_Mutation SNP shallowdel 1 . . . 19 10602848 10602848 C T 19:g.10602848C>T ENST00000171111.5:c.730G>A 0.23 16 55 71 335 3/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-GC-A3WC-01 Bladder Urothelial Carcinoma R116P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.905 Missense_Mutation SNP diploid 2 . . . 19 10610363 10610363 C G 19:g.10610363C>G ENST00000171111.5:c.347G>C 0.15 11 60 66 136 2/6 Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) TCGA-XF-AAMG-01 Bladder Urothelial Carcinoma L471F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.09;Polyphen-2: impact: benign, score: 0.174 Missense_Mutation SNP shallowdel . . . 19 10600444 10600444 G A 19:g.10600444G>A ENST00000171111.5:c.1411C>T 0.09 3 30 38 893 4/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-A4NR-01 Hepatocellular Carcinoma I137T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.673 Missense_Mutation SNP diploid . . . 19 10610300 10610300 A G 19:g.10610300A>G ENST00000171111.5:c.410T>C 0.09 4 43 36 62 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-A1EL-01 Hepatocellular Carcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP shallowdel 1 . . . 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 0.74 28 10 64 88 3/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-G3-AAV5-01 Hepatocellular Carcinoma L115Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.979 Missense_Mutation SNP diploid . . . 19 10610366 10610366 A T 19:g.10610366A>T ENST00000171111.5:c.344T>A 0.34 0.03 27 52 2 71 76 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-CC-A7IK-01 Hepatocellular Carcinoma P278L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.962 Missense_Mutation SNP shallowdel 2 . . . 19 10602745 10602745 G A 19:g.10602745G>A ENST00000171111.5:c.833C>T 0.45 15 18 72 287 3/6 rs1040740503 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-RC-A6M6-01 Hepatocellular Carcinoma P89L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: benign, score: 0.094 Missense_Mutation SNP shallowdel . . . 19 10610444 10610444 G A 19:g.10610444G>A ENST00000171111.5:c.266C>T 0.80 28 7 48 180 2/6 0.00000398086 rs970670762 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-2Y-A9H3-01 Hepatocellular Carcinoma S592G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.28;Polyphen-2: impact: benign, score: 0.082 Missense_Mutation SNP shallowdel . . . 19 10597429 10597429 T C 19:g.10597429T>C ENST00000171111.5:c.1774A>G 0.16 10 53 91 168 6/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AAE7-01 Hepatocellular Carcinoma N157S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.45;Polyphen-2: impact: benign, score: 0.339 Missense_Mutation SNP diploid . . . 19 10610240 10610240 T C 19:g.10610240T>C ENST00000171111.5:c.470A>G 0.14 11 65 88 238 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-G3-A3CK-01 Hepatocellular Carcinoma S104R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid . . . 19 10610398 10610398 G T 19:g.10610398G>T ENST00000171111.5:c.312C>A 0.35 50 94 137 207 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AADM-01 Hepatocellular Carcinoma H311L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: benign, score: 0.005 Missense_Mutation SNP diploid 2 . . . 19 10602646 10602646 T A 19:g.10602646T>A ENST00000171111.5:c.932A>T 0.54 51 44 100 169 3/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-DD-AADM-01 Hepatocellular Carcinoma V168G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.867 Missense_Mutation SNP diploid . . . 19 10610207 10610207 A C 19:g.10610207A>C ENST00000171111.5:c.503T>G 0.33 35 71 105 169 2/6 Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) TCGA-2Y-A9GY-01 Hepatocellular Carcinoma V152G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel . . . 19 10610255 10610255 A C 19:g.10610255A>C ENST00000171111.5:c.455T>G 0.41 26 37 98 68 2/6 Liver Hepatocellular Adenoma and Carcinomas (MSK, PLOS One 2018) s_AV_hcchca_002_T Hepatocellular Carcinoma R135H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP diploid SOMATIC NA MSK-IMPACT 19 10610306 10610306 C T 19:g.10610306C>T ENST00000171111.5:c.404G>A 0.15 113 649 603 5 2/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-D3-A2J7-06 Cutaneous Melanoma P130L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 . . . 19 10610321 10610321 G A 19:g.10610321G>A ENST00000171111.5:c.389C>T 0.20 9 36 61 348 2/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-D3-A1QB-06 Cutaneous Melanoma W544L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP gain 2 . . . 19 10599945 10599945 C A 19:g.10599945C>A ENST00000171111.5:c.1631G>T 0.13 4 28 52 350 5/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-EE-A2GR-06 Cutaneous Melanoma H225N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.55;Polyphen-2: impact: benign, score: 0.193 Missense_Mutation SNP diploid . . . 19 10602905 10602905 G T 19:g.10602905G>T ENST00000171111.5:c.673C>A 0.12 4 30 33 1747 3/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-EE-A3AH-06 Cutaneous Melanoma E218D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.27;Polyphen-2: impact: benign, score: 0.067 Missense_Mutation SNP diploid 4 . . . 19 10602924 10602924 C A 19:g.10602924C>A ENST00000171111.5:c.654G>T 0.08 3 33 20 531 3/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-ER-A19P-06 Cutaneous Melanoma E441D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid . . . 19 10602255 10602255 C A 19:g.10602255C>A ENST00000171111.5:c.1323G>T 0.12 4 29 22 2916 3/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-FS-A1ZJ-06 Cutaneous Melanoma G564W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10599886 10599886 C A 19:g.10599886C>A ENST00000171111.5:c.1690G>T 0.15 5 28 32 464 5/6 Skin Cutaneous Melanoma (TCGA, PanCancer Atlas) TCGA-GN-A263-01 Cutaneous Melanoma R413S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP . . . 19 10602341 10602341 G T 19:g.10602341G>T ENST00000171111.5:c.1237C>A 0.14 3 19 22 472 3/6 Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-IB-7651-01 Pancreatic Adenocarcinoma T543M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.285 Missense_Mutation SNP diploid . . . 19 10599948 10599948 G A 19:g.10599948G>A ENST00000171111.5:c.1628C>T 0.14 28 168 40 14306 5/6 0.000007959121948655732 rs111830952 Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-S4-A8RO-01 Pancreatic Adenocarcinoma A188G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.936 Missense_Mutation SNP diploid . . . 19 10610147 10610147 G C 19:g.10610147G>C ENST00000171111.5:c.563C>G 0.30 37 85 32 48 2/6 rs780645001 Colon Cancer (CPTAC-2 Prospective, Cell 2019) 05CO003 Colon Adenocarcinoma G433D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.984 Missense_Mutation SNP diploid NA NA NA 19 10602280 10602280 C T 19:g.10602280C>T ENST00000171111.5:c.1298G>A 707 3/6 Metastatic Melanoma (DFCI, Science 2015) Pat138 Cutaneous Melanoma S431F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP diploid Somatic Untested MSKCC 19 10602286 10602286 G A 19:g.10602286G>A ENST00000171111.5:c.1292C>T 0.25 17 50 32 5025 3/6 Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-AA-3715-01 Colon Adenocarcinoma I125V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.672 Missense_Mutation SNP diploid 1 . . . 19 10610337 10610337 T C 19:g.10610337T>C ENST00000171111.5:c.373A>G 0.19 14 61 16 2120 2/6 Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-AA-3984-01 Colon Adenocarcinoma M503I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.984 Missense_Mutation SNP diploid 2 . . . 19 10600346 10600346 C A 19:g.10600346C>A ENST00000171111.5:c.1509G>T 0.33 35 72 89 5116 4/6 Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-A6-2686-01 Colon Adenocarcinoma T80I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.17;Polyphen-2: impact: possibly_damaging, score: 0.489 Missense_Mutation SNP diploid . . . 19 10610471 10610471 G A 19:g.10610471G>A ENST00000171111.5:c.239C>T 0.52 14 13 92 2138 2/6 Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-AA-A01R-01 Mucinous Adenocarcinoma of the Colon and Rectum S8N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.1;Polyphen-2: impact: possibly_damaging, score: 0.483 Missense_Mutation SNP diploid . . . 19 10610687 10610687 C T 19:g.10610687C>T ENST00000171111.5:c.23G>A 0.38 18 29 82 1621 2/6 0.0000047669 rs746950247 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-UF-A7JO-01 Head and Neck Squamous Cell Carcinoma S45F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP shallowdel 3 . . . 19 10610576 10610576 G A 19:g.10610576G>A ENST00000171111.5:c.134C>T 0.05 7 125 187 154 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-BA-7269-01 Head and Neck Squamous Cell Carcinoma T598A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.28;Polyphen-2: impact: benign, score: 0.019 Missense_Mutation SNP shallowdel . . . 19 10597411 10597411 T C 19:g.10597411T>C ENST00000171111.5:c.1792A>G 0.53 49 44 167 79 6/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-4723-01 Head and Neck Squamous Cell Carcinoma D29H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.009 Missense_Mutation SNP diploid . . . 19 10610625 10610625 C G 19:g.10610625C>G ENST00000171111.5:c.85G>C 0.22 36 127 207 742 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-4727-01 Head and Neck Squamous Cell Carcinoma S45Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 3 . . . 19 10610576 10610576 G T 19:g.10610576G>T ENST00000171111.5:c.134C>A 0.19 42 183 275 385 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-6010-01 Head and Neck Squamous Cell Carcinoma Q178L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.903 Missense_Mutation SNP diploid . . . 19 10610177 10610177 T A 19:g.10610177T>A ENST00000171111.5:c.533A>T 0.38 6 10 42 1665 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-6012-01 Head and Neck Squamous Cell Carcinoma S103Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.961 Missense_Mutation SNP shallowdel . . . 19 10610402 10610402 G T 19:g.10610402G>T ENST00000171111.5:c.308C>A 0.30 12 28 57 109 2/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CR-6492-01 Head and Neck Squamous Cell Carcinoma A607P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid . . . 19 10597384 10597384 C G 19:g.10597384C>G ENST00000171111.5:c.1819G>C 0.06 8 125 131 51 6/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CV-7248-01 Head and Neck Squamous Cell Carcinoma C319F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.24;Polyphen-2: impact: benign, score: 0.009 Missense_Mutation SNP diploid . . . 19 10602622 10602622 C A 19:g.10602622C>A ENST00000171111.5:c.956G>T 0.27 14 37 67 267 3/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-UF-A7JT-01 Head and Neck Squamous Cell Carcinoma I425M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.11;Polyphen-2: impact: possibly_damaging, score: 0.809 Missense_Mutation SNP diploid . . . 19 10602303 10602303 G C 19:g.10602303G>C ENST00000171111.5:c.1275C>G 0.26 7 20 30 173 3/6 0.000017396 rs754011905 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-KU-A66S-01 Head and Neck Squamous Cell Carcinoma R234W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP diploid . . . 19 10602878 10602878 G A 19:g.10602878G>A ENST00000171111.5:c.700C>T 0.20 13 51 107 478 3/6 Uncertain significance rs1599484704 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-UF-A71E-01 Head and Neck Squamous Cell Carcinoma P278L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.962 Missense_Mutation SNP shallowdel 2 . . . 19 10602745 10602745 G A 19:g.10602745G>A ENST00000171111.5:c.833C>T 0.56 46 36 87 134 3/6 rs1040740503 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-P3-A6T0-01 Head and Neck Squamous Cell Carcinoma V239M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.984 Missense_Mutation SNP diploid . . . 19 10602863 10602863 C T 19:g.10602863C>T ENST00000171111.5:c.715G>A 0.58 43 31 92 78 3/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-HD-A633-01 Head and Neck Squamous Cell Carcinoma I519M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.879 Missense_Mutation SNP diploid . . . 19 10600019 10600019 G C 19:g.10600019G>C ENST00000171111.5:c.1557C>G 0.17 9 44 53 122 5/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-T2-A6WX-01 Head and Neck Squamous Cell Carcinoma E218K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.657 Missense_Mutation SNP diploid 4 . . . 19 10602926 10602926 C T 19:g.10602926C>T ENST00000171111.5:c.652G>A 0.08 4 47 65 174 3/6 Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-CN-6010-01 Head and Neck Squamous Cell Carcinoma Q177H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.45;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP diploid . . . 19 10610179 10610179 C A 19:g.10610179C>A ENST00000171111.5:c.531G>T 0.32 6 13 46 1665 2/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H091730 Hepatocellular Adenoma E149K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.988 Missense_Mutation SNP diploid Somatic Unknown LGGM 19 10610265 10610265 C T 19:g.10610265C>T ENST00000171111.5:c.445G>A 0.67 12 6 48 2/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H092093 Hepatocellular Adenoma I137T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.673 Missense_Mutation SNP diploid Somatic Unknown LGGM 19 10610300 10610300 A G 19:g.10610300A>G ENST00000171111.5:c.410T>C 0.31 4 9 106 2/6 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H093650 Hepatocellular Adenoma Y520C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid Somatic Unknown LGGM 19 10600017 10600017 T C 19:g.10600017T>C ENST00000171111.5:c.1559A>G 0.14 3 18 91 5/6 0.0000159288 rs753646735 Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) H110224 Hepatocellular Adenoma R116L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.735 Missense_Mutation SNP diploid 2 Somatic Unknown LGGM 19 10610363 10610363 C A 19:g.10610363C>A ENST00000171111.5:c.347G>T 0.15 2 11 57 2/6 Adrenocortical Carcinoma (TCGA, PanCancer Atlas) TCGA-OU-A5PI-01 Adrenocortical Carcinoma L153V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.684 Missense_Mutation SNP gain . . . 19 10610253 10610253 G C 19:g.10610253G>C ENST00000171111.5:c.457C>G 0.22 0.0039 95 344 1 256 28 2/6 Adrenocortical Carcinoma (TCGA, PanCancer Atlas) TCGA-P6-A5OH-01 Adrenocortical Carcinoma V465M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.992 Missense_Mutation SNP gain . . . 19 10600462 10600462 C T 19:g.10600462C>T ENST00000171111.5:c.1393G>A 0.12 27 204 49 125 4/6 Esophageal Adenocarcinoma (DFCI, Nat Genet 2013) ESO-H63 Esophageal Adenocarcinoma V324M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.393 Missense_Mutation SNP 1 Somatic NA broad.mit.edu 19 10602608 10602608 C T 19:g.10602608C>T ENST00000171111.5:c.970G>A 0.19 6 26 73 3/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) BCB301T Hepatocellular Carcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP 1 NA Valid inserm.fr 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 43 3/6 Hepatocellular Carcinomas (INSERM, Nat Genet 2015) CHC1616T Hepatocellular Carcinoma R71Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP 1 NA Valid inserm.fr 19 10610498 10610498 C T 19:g.10610498C>T ENST00000171111.5:c.212G>A 76 2/6 0.00000796343 rs1443914847 Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) DS-uttcc-060-P Upper Tract Urothelial Carcinoma D585N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0.059 Missense_Mutation SNP diploid Somatic high mskcc.org 19 10597450 10597450 C T 19:g.10597450C>T ENST00000171111.5:c.1753G>A 0.61 0.98 340 221 216 5 422 6/6 0.0000358143 rs200652594 Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) P-0004688-T01-IM5 Upper Tract Urothelial Carcinoma G433S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.862 Missense_Mutation SNP diploid SOMATIC Unknown MSKCC 19 10602281 10602281 C T 19:g.10602281C>T ENST00000171111.5:c.1297G>A 0.13 110 717 344 413 3/6 Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014) CSCC-29-T Cutaneous Squamous Cell Carcinoma E593K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.47;Polyphen-2: impact: benign, score: 0.321 Missense_Mutation SNP Somatic Untested hgsc.bcm.edu 19 10597426 10597426 C T 19:g.10597426C>T ENST00000171111.5:c.1777G>A 0.35 40 75 85 3405 6/6 0.000007955133048591002 rs887838584 Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014) CSCC-19-T Cutaneous Squamous Cell Carcinoma V152N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation DNP Somatic Untested hgsc.bcm.edu 19 10610255 10610256 AC TT 19:g.10610255_10610256delinsTT ENST00000171111.5:c.454_455delinsAA 1283 2/6 Basal Cell Carcinoma (UNIGE, Nat Genet 2016) 5-VS065-T1 Skin Cancer, Non-Melanoma R554Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP 2 NA NA NA 19 10599915 10599915 C T 19:g.10599915C>T ENST00000171111.5:c.1661G>A 0.22 17 59 78 5/6 Basal Cell Carcinoma (UNIGE, Nat Genet 2016) 5-GE026-T3 Skin Cancer, Non-Melanoma L472F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.908 Missense_Mutation SNP NA NA NA 19 10600441 10600441 G A 19:g.10600441G>A ENST00000171111.5:c.1414C>T 0.44 40 50 106 4/6 Basal Cell Carcinoma (UNIGE, Nat Genet 2016) 5-GE079-T1 Skin Cancer, Non-Melanoma A270V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation DNP NA NA NA 19 10602768 10602769 GG AA 19:g.10602768_10602769delinsAA ENST00000171111.5:c.809_810delinsTT 0.13 9 61 26 3/6 Basal Cell Carcinoma (UNIGE, Nat Genet 2016) 5-VS062-T1 Skin Cancer, Non-Melanoma R354W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.941 Missense_Mutation SNP 1 NA NA NA 19 10602518 10602518 G A 19:g.10602518G>A ENST00000171111.5:c.1060C>T 0.30 25 57 115 3/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) SU2C_Lung-SU2C-DFCI-LUAD-1003-Tumor-SM-AOL4D Lung Adenocarcinoma I137T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.673 Missense_Mutation SNP NA NA NA 19 10610300 10610300 A G 19:g.10610300A>G ENST00000171111.5:c.410T>C 0.16 39 200 123 2/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) GR4788 Lung Squamous Cell Carcinoma V99L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP 1 NA NA NA 19 10610415 10610415 C A 19:g.10610415C>A ENST00000171111.5:c.295G>T 0.09 3 30 95 2/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) LUAD-BS-10-R22401-Tumor-SM-9J2XK Lung Adenocarcinoma V271M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.95 Missense_Mutation SNP 1 NA NA NA 19 10602767 10602767 C T 19:g.10602767C>T ENST00000171111.5:c.811G>A 0.04 8 177 159 3/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) MEL-IPI_Pat138-Tumor-SM-7A155 Cutaneous Melanoma S431F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.05;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP NA NA NA 19 10602286 10602286 G A 19:g.10602286G>A ENST00000171111.5:c.1292C>T 0.25 12 36 5887 3/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) HE3202 Lung Adenocarcinoma G195V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.881 Missense_Mutation SNP 1 NA NA NA 19 10610126 10610126 C A 19:g.10610126C>A ENST00000171111.5:c.584G>T 0.43 15 20 680 2/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) HE3202 Lung Adenocarcinoma G195C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.964 Missense_Mutation SNP 1 NA NA NA 19 10610127 10610127 C A 19:g.10610127C>A ENST00000171111.5:c.583G>T 0.44 15 19 680 2/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) DFCI_11-104_011-Tumor-SM-5PA3E Bladder Urothelial Carcinoma Q620H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.13;Polyphen-2: impact: benign, score: 0.146 Missense_Mutation SNP NA NA NA 19 10597343 10597343 C A 19:g.10597343C>A ENST00000171111.5:c.1860G>T 0.15 60 347 505 6/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) LUAD-BS-13-X14864-Tumor-SM-9J2XQ Non-Small Cell Lung Cancer G564V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP NA NA NA 19 10599885 10599885 C A 19:g.10599885C>A ENST00000171111.5:c.1691G>T 0.63 10 6 966 5/6 MSS Mixed Solid Tumors (Broad/Dana-Farber, Nat Genet 2018) SU2C_Lung-SU2C-DFCI-LUAD-1017-Tumor-SM-AOL99 Lung Adenocarcinoma R483P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP 2 NA NA NA 19 10600407 10600407 C G 19:g.10600407C>G ENST00000171111.5:c.1448G>C 0.55 36 30 1180 4/6 Unclassified Renal Cell Carcinoma (MSK, Nature 2016) T32 Unclassified Renal Cell Carcinoma C297Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.87 Missense_Mutation SNP diploid NA NA NA 19 10602688 10602688 C T 19:g.10602688C>T ENST00000171111.5:c.890G>A 1 3/6 Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015_S01516 Small Cell Lung Cancer R234P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.806 Missense_Mutation SNP NA NA ucologne 19 10602877 10602877 C G 19:g.10602877C>G ENST00000171111.5:c.701G>C 0.58 19 14 209 3/6 Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015_S02273 Small Cell Lung Cancer C196F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.981 Missense_Mutation SNP NA NA ucologne 19 10610123 10610123 C A 19:g.10610123C>A ENST00000171111.5:c.587G>T 0.83 19 4 534 2/6 Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015_S02120 Small Cell Lung Cancer A40V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.962 Missense_Mutation SNP NA NA ucologne 19 10610591 10610591 G A 19:g.10610591G>A ENST00000171111.5:c.119C>T 0.36 19 34 323 2/6 0.00000799431 rs1173824866 Metastatic Solid Cancers (UMich, Nature 2017) MO_1260 Prostate Adenocarcinoma A191T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.977 Missense_Mutation SNP 2 NA NA University of Michigan 19 10610139 10610139 C T 19:g.10610139C>T ENST00000171111.5:c.571G>A 0.39 117 185 225 657 2/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1012 Prostate Neuroendocrine Carcinoma A95V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.42;Polyphen-2: impact: benign, score: 0.306 Missense_Mutation SNP 1 NA NA University of Michigan 19 10610426 10610426 G A 19:g.10610426G>A ENST00000171111.5:c.284C>T 0.51 23 22 46 1021 2/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1125 Poorly Differentiated Non-Small Cell Lung Cancer G332C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP NA NA University of Michigan 19 10602584 10602584 C A 19:g.10602584C>A ENST00000171111.5:c.994G>T 0.59 203 139 125 398 3/6 rs1208201314 Metastatic Solid Cancers (UMich, Nature 2017) MO_1541 Prostate Adenocarcinoma P412T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: probably_damaging, score: 0.928 Missense_Mutation SNP NA NA University of Michigan 19 10602344 10602344 G T 19:g.10602344G>T ENST00000171111.5:c.1234C>A 0.31 0.0028 130 295 1 350 96 3/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1109 Merkel Cell Carcinoma G564E OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP NA NA University of Michigan 19 10599885 10599885 C T 19:g.10599885C>T ENST00000171111.5:c.1691G>A 0.46 48 56 72 1137 5/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1163 Poorly Differentiated Non-Small Cell Lung Cancer Y443H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP NA NA University of Michigan 19 10600528 10600528 A G 19:g.10600528A>G ENST00000171111.5:c.1327T>C 0.85 164 30 251 578 4/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1347 Extrahepatic Cholangiocarcinoma A266T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.57;Polyphen-2: impact: possibly_damaging, score: 0.673 Missense_Mutation SNP NA NA University of Michigan 19 10602782 10602782 C T 19:g.10602782C>T ENST00000171111.5:c.796G>A 0.13 62 419 404 6107 3/6 Metastatic Solid Cancers (UMich, Nature 2017) MO_1347 Extrahepatic Cholangiocarcinoma F262L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.77;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP NA NA University of Michigan 19 10602794 10602794 A G 19:g.10602794A>G ENST00000171111.5:c.784T>C 0.13 64 429 405 6107 3/6 Metastatic Solid Cancers (UMich, Nature 2017) TP_2130 Sinonasal Squamous Cell Carcinoma M161I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.877 Missense_Mutation SNP 1 NA NA University of Michigan 19 10610227 10610227 C T 19:g.10610227C>T ENST00000171111.5:c.483G>A 0.23 55 183 167 121 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-EO-A22R-01 Uterine Endometrioid Carcinoma D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP diploid 4 . . . 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 0.38 13 21 21 12771 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-D1-A103-01 Uterine Endometrioid Carcinoma R50H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.854 Missense_Mutation SNP diploid 2 . . . 19 10610561 10610561 C T 19:g.10610561C>T ENST00000171111.5:c.149G>A 0.18 4 18 11 6849 2/6 0.0000199542 rs766652922 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AX-A063-01 Uterine Endometrioid Carcinoma I185T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.979 Missense_Mutation SNP diploid 2 . . . 19 10610156 10610156 A G 19:g.10610156A>G ENST00000171111.5:c.554T>C 0.32 6 13 25 999 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-D1-A103-01 Uterine Endometrioid Carcinoma R326H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.24;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP diploid 1 . . . 19 10602601 10602601 C T 19:g.10602601C>T ENST00000171111.5:c.977G>A 0.23 6 20 10 6849 3/6 0.00000409588 rs751665354 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-D1-A103-01 Uterine Endometrioid Carcinoma A95T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.05;Polyphen-2: impact: possibly_damaging, score: 0.526 Missense_Mutation SNP diploid 1 . . . 19 10610427 10610427 C T 19:g.10610427C>T ENST00000171111.5:c.283G>A 0.33 18 37 28 6849 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-EY-A215-01 Uterine Endometrioid Carcinoma R261Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.62;Polyphen-2: impact: benign, score: 0.058 Missense_Mutation SNP diploid 1 . . . 19 10602796 10602796 C T 19:g.10602796C>T ENST00000171111.5:c.782G>A 0.31 16 36 63 4650 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-E6-A2P9-01 Uterine Endometrioid Carcinoma V152A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid . . . 19 10610255 10610255 A G 19:g.10610255A>G ENST00000171111.5:c.455T>C 0.23 3 10 12 864 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-B5-A3FC-01 Uterine Endometrioid Carcinoma A91T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.039 Missense_Mutation SNP diploid 1 . . . 19 10610439 10610439 C T 19:g.10610439C>T ENST00000171111.5:c.271G>A 0.44 16 20 44 12211 2/6 0.0002906444342475315 rs202181679 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AJ-A3BG-01 Uterine Mixed Endometrial Carcinoma R483C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.996 Missense_Mutation SNP diploid 2 . . . 19 10600408 10600408 G A 19:g.10600408G>A ENST00000171111.5:c.1447C>T 0.58 11 8 27 1274 4/6 0.0000318918 rs1412883238 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-DI-A1BU-01 Uterine Mixed Endometrial Carcinoma V98A OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.67 Missense_Mutation SNP diploid . . . 19 10610417 10610417 A G 19:g.10610417A>G ENST00000171111.5:c.293T>C 0.25 15 45 25 7642 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-FI-A2D5-01 Uterine Endometrioid Carcinoma A109T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10610385 10610385 C T 19:g.10610385C>T ENST00000171111.5:c.325G>A 0.18 7 32 36 13865 2/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AJ-A3BF-01 Uterine Serous Carcinoma/Uterine Papillary Serous Carcinoma P492R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.994 Missense_Mutation SNP shallowdel . . . 19 10600380 10600380 G C 19:g.10600380G>C ENST00000171111.5:c.1475C>G 0.67 8 4 21 26 4/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AJ-A3BG-01 Uterine Mixed Endometrial Carcinoma G332D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid . . . 19 10602583 10602583 C T 19:g.10602583C>T ENST00000171111.5:c.995G>A 0.37 13 22 49 1274 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-AX-A3G8-01 Uterine Endometrioid Carcinoma R553Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.21;Polyphen-2: impact: benign, score: 0.292 Missense_Mutation SNP diploid . . . 19 10599918 10599918 C T 19:g.10599918C>T ENST00000171111.5:c.1658G>A 0.64 48 27 58 782 5/6 0.0000119471 rs142453344 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-DI-A1BU-01 Uterine Mixed Endometrial Carcinoma Y345H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.986 Missense_Mutation SNP diploid . . . 19 10602545 10602545 A G 19:g.10602545A>G ENST00000171111.5:c.1033T>C 0.25 16 49 21 7642 3/6 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-FI-A2D0-01 Uterine Endometrioid Carcinoma A392T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.39;Polyphen-2: impact: benign, score: 0.03 Missense_Mutation SNP diploid . . . 19 10602404 10602404 C T 19:g.10602404C>T ENST00000171111.5:c.1174G>A 0.22 7 25 32 6445 3/6 rs1432914621 Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) TCGA-QS-A5YQ-01 Uterine Endometrioid Carcinoma M499I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.035 Missense_Mutation SNP diploid . . . 19 10600358 10600358 C A 19:g.10600358C>A ENST00000171111.5:c.1497G>T 0.12 3 22 32 932 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-99-8033-01 Lung Adenocarcinoma R554Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10599915 10599915 C T 19:g.10599915C>T ENST00000171111.5:c.1661G>A 0.17 7 35 53 168 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-6779-01 Lung Adenocarcinoma T142M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10610285 10610285 G A 19:g.10610285G>A ENST00000171111.5:c.425C>T 0.42 17 23 54 91 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-91-6848-01 Lung Adenocarcinoma D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP gain 4 . . . 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 0.60 0.01 36 24 1 96 562 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-73-4666-01 Lung Adenocarcinoma G603W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10597396 10597396 C A 19:g.10597396C>A ENST00000171111.5:c.1807G>T 0.36 61 107 219 342 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-05-4384-01 Lung Adenocarcinoma G524C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 2 . . . 19 10600006 10600006 C A 19:g.10600006C>A ENST00000171111.5:c.1570G>T 0.29 11 27 32 117 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-05-4389-01 Lung Adenocarcinoma F246L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: benign, score: 0.251 Missense_Mutation SNP shallowdel 1 . . . 19 10602840 10602840 G C 19:g.10602840G>C ENST00000171111.5:c.738C>G 0.42 24 33 57 210 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-2655-01 Lung Adenocarcinoma S144F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.877 Missense_Mutation SNP shallowdel 1 . . . 19 10610279 10610279 G A 19:g.10610279G>A ENST00000171111.5:c.431C>T 0.16 11 56 84 164 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z011-01 Lung Adenocarcinoma S144F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: possibly_damaging, score: 0.877 Missense_Mutation SNP 1 . . . 19 10610279 10610279 G A 19:g.10610279G>A ENST00000171111.5:c.431C>T 0.25 5 15 31 103 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-7671-01 Lung Adenocarcinoma P278S OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.96 Missense_Mutation SNP shallowdel 2 . . . 19 10602746 10602746 G A 19:g.10602746G>A ENST00000171111.5:c.832C>T 0.64 36 20 98 200 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-4488-01 Lung Adenocarcinoma Q284L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.864 Missense_Mutation SNP diploid 1 . . . 19 10602727 10602727 T A 19:g.10602727T>A ENST00000171111.5:c.851A>T 0.58 22 16 44 270 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-7995-01 Lung Adenocarcinoma Q284L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.864 Missense_Mutation SNP shallowdel 1 . . . 19 10602727 10602727 T A 19:g.10602727T>A ENST00000171111.5:c.851A>T 0.48 39 42 105 606 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-4506-01 Lung Adenocarcinoma M503K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.995 Missense_Mutation SNP diploid 2 . . . 19 10600347 10600347 A T 19:g.10600347A>T ENST00000171111.5:c.1508T>A 0.26 17 49 96 116 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-6742-01 Lung Adenocarcinoma L268P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.977 Missense_Mutation SNP shallowdel 1 . . . 19 10602775 10602775 A G 19:g.10602775A>G ENST00000171111.5:c.803T>C 0.20 9 37 87 237 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-50-5939-01 Lung Adenocarcinoma R261P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.33;Polyphen-2: impact: possibly_damaging, score: 0.806 Missense_Mutation SNP shallowdel 1 . . . 19 10602796 10602796 C G 19:g.10602796C>G ENST00000171111.5:c.782G>C 0.25 14 41 59 75 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-7815-01 Lung Adenocarcinoma A191T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.977 Missense_Mutation SNP diploid 2 . . . 19 10610139 10610139 C T 19:g.10610139C>T ENST00000171111.5:c.571G>A 0.13 6 40 33 126 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-64-5781-01 Lung Adenocarcinoma V99L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP diploid 1 . . . 19 10610415 10610415 C A 19:g.10610415C>A ENST00000171111.5:c.295G>T 0.53 21 19 38 1023 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-73-7498-01 Lung Adenocarcinoma E218V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.691 Missense_Mutation SNP shallowdel 4 . . . 19 10602925 10602925 T A 19:g.10602925T>A ENST00000171111.5:c.653A>T 0.48 30 33 66 98 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-75-6211-01 Lung Adenocarcinoma R204P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.968 Missense_Mutation SNP shallowdel 1 . . . 19 10610099 10610099 C G 19:g.10610099C>G ENST00000171111.5:c.611G>C 0.63 5 3 14 340 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7149-01 Lung Adenocarcinoma W497L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 0.992 Missense_Mutation SNP shallowdel 1 . . . 19 10600365 10600365 C A 19:g.10600365C>A ENST00000171111.5:c.1490G>T 0.63 48 28 96 137 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7153-01 Lung Adenocarcinoma E117K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP shallowdel 1 . . . 19 10610361 10610361 C T 19:g.10610361C>T ENST00000171111.5:c.349G>A 0.19 8 34 48 115 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7154-01 Lung Adenocarcinoma W252C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.983 Missense_Mutation SNP gain 1 . . . 19 10602822 10602822 C A 19:g.10602822C>A ENST00000171111.5:c.756G>T 0.63 45 26 88 210 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-78-7166-01 Lung Adenocarcinoma F280Y OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: benign, score: 0.19 Missense_Mutation SNP shallowdel 1 . . . 19 10602739 10602739 A T 19:g.10602739A>T ENST00000171111.5:c.839T>A 0.43 34 45 69 194 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-95-7043-01 Lung Adenocarcinoma L100P OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel 1 . . . 19 10610411 10610411 A G 19:g.10610411A>G ENST00000171111.5:c.299T>C 0.92 23 2 42 1018 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-95-7947-01 Lung Adenocarcinoma S102L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.971 Missense_Mutation SNP diploid 1 . . . 19 10610405 10610405 G A 19:g.10610405G>A ENST00000171111.5:c.305C>T 0.43 16 21 52 476 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-7660-01 Lung Adenocarcinoma V271M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.95 Missense_Mutation SNP shallowdel 1 . . . 19 10602767 10602767 C T 19:g.10602767C>T ENST00000171111.5:c.811G>A 0.53 32 28 98 334 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-44-7669-01 Lung Adenocarcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP shallowdel 1 . . . 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 0.49 26 27 65 421 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AAR2-01 Lung Adenocarcinoma V271L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.636 Missense_Mutation SNP shallowdel 1 . . . 19 10602767 10602767 C A 19:g.10602767C>A ENST00000171111.5:c.811G>T 0.52 17 16 70 364 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AAR3-01 Lung Adenocarcinoma A101G OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10610408 10610408 G C 19:g.10610408G>C ENST00000171111.5:c.302C>G 0.28 8 21 44 127 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AAR9-01 Lung Adenocarcinoma G332C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10602584 10602584 C A 19:g.10602584C>A ENST00000171111.5:c.994G>T 0.60 9 6 37 565 3/6 rs1208201314 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-4B-A93V-01 Lung Adenocarcinoma L199F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.999 Missense_Mutation SNP diploid . . . 19 10610113 10610113 C A 19:g.10610113C>A ENST00000171111.5:c.597G>T 0.46 6 7 13 123 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-53-7624-01 Lung Adenocarcinoma K97N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.99 Missense_Mutation SNP diploid 1 . . . 19 10610419 10610419 C A 19:g.10610419C>A ENST00000171111.5:c.291G>T 0.78 40 11 48 744 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-6987-01 Lung Adenocarcinoma R116W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.96 Missense_Mutation SNP diploid 2 . . . 19 10610364 10610364 G A 19:g.10610364G>A ENST00000171111.5:c.346C>T 0.12 5 37 34 214 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8094-01 Lung Adenocarcinoma Y162C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.983 Missense_Mutation SNP shallowdel . . . 19 10610225 10610225 T C 19:g.10610225T>C ENST00000171111.5:c.485A>G 0.38 44 72 166 395 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8506-01 Lung Adenocarcinoma Q616H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: benign, score: 0.059 Missense_Mutation SNP diploid . . . 19 10597355 10597355 C A 19:g.10597355C>A ENST00000171111.5:c.1848G>T 0.28 74 188 303 1583 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-55-8510-01 Lung Adenocarcinoma D235H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.975 Missense_Mutation SNP diploid . . . 19 10602875 10602875 C G 19:g.10602875C>G ENST00000171111.5:c.703G>C 0.32 20 43 86 275 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-73-4670-01 Lung Adenocarcinoma V123L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.871 Missense_Mutation SNP shallowdel 1 . . . 19 10610343 10610343 C A 19:g.10610343C>A ENST00000171111.5:c.367G>T 0.57 24 18 72 331 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-75-6206-01 Lung Adenocarcinoma V214L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.998 Missense_Mutation SNP shallowdel 1 . . . 19 10602938 10602938 C A 19:g.10602938C>A ENST00000171111.5:c.640G>T 0.67 6 3 30 81 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-86-8358-01 Lung Adenocarcinoma G558E OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid . . . 19 10599903 10599903 C T 19:g.10599903C>T ENST00000171111.5:c.1673G>A 0.87 13 2 46 952 5/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-97-A4M3-01 Lung Adenocarcinoma E219Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: possibly_damaging, score: 0.677 Missense_Mutation SNP shallowdel . . . 19 10602923 10602923 C G 19:g.10602923C>G ENST00000171111.5:c.655G>C 0.35 16 30 64 192 3/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-NJ-A4YQ-01 Lung Adenocarcinoma V79L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.496 Missense_Mutation SNP shallowdel . . . 19 10610475 10610475 C G 19:g.10610475C>G ENST00000171111.5:c.235G>C 0.17 13 64 93 998 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-NJ-A55R-01 Lung Adenocarcinoma G571D OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP shallowdel . . . 19 10597491 10597491 C T 19:g.10597491C>T ENST00000171111.5:c.1712G>A 0.23 15 50 269 232 6/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-49-AAR0-01 Lung Adenocarcinoma G511C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP shallowdel . . . 19 10600324 10600324 C A 19:g.10600324C>A ENST00000171111.5:c.1531G>T 0.46 18 21 49 122 4/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z018-01 Lung Adenocarcinoma M156V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: benign, score: 0.322 Missense_Mutation SNP 1 . . . 19 10610244 10610244 T C 19:g.10610244T>C ENST00000171111.5:c.466A>G 0.28 11 28 31 234 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-17-Z026-01 Lung Adenocarcinoma Q163H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP . . . 19 10610221 10610221 C A 19:g.10610221C>A ENST00000171111.5:c.489G>T 0.28 11 29 28 873 2/6 Lung Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-80-5608-01 Lung Adenocarcinoma Q92K OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.96;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP shallowdel . . . 19 10610436 10610436 G T 19:g.10610436G>T ENST00000171111.5:c.274C>A 0.09 3 32 78 342 2/6 Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) MO_1012-Tumor-Subcutaneous_nodule Prostate Adenocarcinoma A95V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.42;Polyphen-2: impact: benign, score: 0.306 Missense_Mutation SNP diploid 1 Somatic Untested broad.mit.edu 19 10610426 10610426 G A 19:g.10610426G>A ENST00000171111.5:c.284C>T 0.54 27 23 1093 2/6 Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) SC_9008-Tumor Prostate Adenocarcinoma G11R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated_low_confidence, score: 0.14;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP diploid Somatic Untested broad.mit.edu 19 10610679 10610679 C T 19:g.10610679C>T ENST00000171111.5:c.31G>A 0.03 6 192 1247 2/6 Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) SC_9084-TM Prostate Adenocarcinoma Y300C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.817 Missense_Mutation SNP diploid Somatic Untested broad.mit.edu 19 10602679 10602679 T C 19:g.10602679T>C ENST00000171111.5:c.899A>G 0.24 140 453 44 3/6 Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) PM14-TM Prostate Adenocarcinoma A356V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: possibly_damaging, score: 0.724 Missense_Mutation SNP diploid Somatic Untested broad.mit.edu 19 10602511 10602511 G A 19:g.10602511G>A ENST00000171111.5:c.1067C>T 0.03 5 184 46 3/6 0.0000175185 rs754728119 Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) MO_1541_T Prostate Adenocarcinoma P412T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.07;Polyphen-2: impact: probably_damaging, score: 0.928 Missense_Mutation SNP amp Somatic Untested broad.mit.edu 19 10602344 10602344 G T 19:g.10602344G>T ENST00000171111.5:c.1234C>A 0.31 146 318 91 3/6 The Angiosarcoma Project (Provisional, July 2020) RP-1447_ASCProject_YqsAUeFb_T1_v2_Exome Angiosarcoma D448V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.982 Missense_Mutation SNP shallowdel __UNKNOWN__ NA __UNKNOWN__ 19 10600512 10600512 T A 19:g.10600512T>A ENST00000171111.5:c.1343A>T 1466 4/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-BR-4184-01 Stomach Adenocarcinoma A34T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: benign, score: 0.183 Missense_Mutation SNP diploid 1 . . . 19 10610610 10610610 C T 19:g.10610610C>T ENST00000171111.5:c.100G>A 0.24 15 47 82 3126 2/6 0.00001604441092740109 rs372654184 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-BR-6452-01 Stomach Adenocarcinoma S45F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.997 Missense_Mutation SNP diploid 3 . . . 19 10610576 10610576 G A 19:g.10610576G>A ENST00000171111.5:c.134C>T 0.10 12 111 101 5048 2/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-BR-8372-01 Stomach Adenocarcinoma Y537H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 . . . 19 10599967 10599967 A G 19:g.10599967A>G ENST00000171111.5:c.1609T>C 0.23 5 17 64 1158 5/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-BR-8680-01 Tubular Stomach Adenocarcinoma R50H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.854 Missense_Mutation SNP diploid 2 . . . 19 10610561 10610561 C T 19:g.10610561C>T ENST00000171111.5:c.149G>A 0.39 70 110 268 5414 2/6 0.0000199542 rs766652922 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CD-A4MG-01 Diffuse Type Stomach Adenocarcinoma V214M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 1 Missense_Mutation SNP diploid 1 . . . 19 10602938 10602938 C T 19:g.10602938C>T ENST00000171111.5:c.640G>A 0.09 5 50 64 2185 3/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CG-4305-01 Stomach Adenocarcinoma H311R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.2;Polyphen-2: impact: benign, score: 0.003 Missense_Mutation SNP diploid 2 . . . 19 10602646 10602646 T C 19:g.10602646T>C ENST00000171111.5:c.932A>G 0.21 15 58 94 1092 3/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CG-5721-01 Intestinal Type Stomach Adenocarcinoma T541I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: benign, score: 0.166 Missense_Mutation SNP diploid 1 . . . 19 10599954 10599954 G A 19:g.10599954G>A ENST00000171111.5:c.1622C>T 0.13 9 60 55 3725 5/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-CG-5721-01 Intestinal Type Stomach Adenocarcinoma C288R OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: possibly_damaging, score: 0.669 Missense_Mutation SNP diploid 1 . . . 19 10602716 10602716 A G 19:g.10602716A>G ENST00000171111.5:c.862T>C 0.18 13 60 78 3725 3/6 Stomach Adenocarcinoma (TCGA, PanCancer Atlas) TCGA-MX-A666-01 Stomach Adenocarcinoma K84N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.46;Polyphen-2: impact: benign, score: 0.233 Missense_Mutation SNP shallowdel . . . 19 10610458 10610458 C G 19:g.10610458C>G ENST00000171111.5:c.252G>C 0.09 6 63 64 105 2/6 Cholangiocarcinoma (TCGA, PanCancer Atlas) TCGA-ZH-A8Y8-01 Intrahepatic Cholangiocarcinoma A95V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.42;Polyphen-2: impact: benign, score: 0.306 Missense_Mutation SNP diploid 1 . . . 19 10610426 10610426 G A 19:g.10610426G>A ENST00000171111.5:c.284C>T 0.22 4 14 20 32 2/6 Cholangiocarcinoma (TCGA, PanCancer Atlas) TCGA-W5-AA2X-01 Perihilar Cholangiocarcinoma Y300_L301del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL shallowdel . . . 19 10602675 10602680 CAGGTA - 19:g.10602675_10602680del ENST00000171111.5:c.898_903del 0.41 7 10 34 58 3/6 Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) TCGA-JW-A5VK-01 Cervical Squamous Cell Carcinoma R234W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.94 Missense_Mutation SNP shallowdel . . . 19 10602878 10602878 G A 19:g.10602878G>A ENST00000171111.5:c.700C>T 0.62 24 15 22 39 3/6 Uncertain significance rs1599484704 Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) WCM329_1 Bladder/Urinary Tract D538N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.48;Polyphen-2: impact: benign, score: 0.136 Missense_Mutation SNP diploid Somatic Untested THE CARYL AND ISRAEL ENGLANDER INSTITUTE FOR PRECISION MEDICINE 19 10599964 10599964 C T 19:g.10599964C>T ENST00000171111.5:c.1612G>A 281 5/6 0.000007956462237619595 rs1364007421 Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) WCM407_2 Bladder/Urinary Tract V534M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.13;Polyphen-2: impact: benign, score: 0.087 Missense_Mutation SNP diploid Somatic Untested THE CARYL AND ISRAEL ENGLANDER INSTITUTE FOR PRECISION MEDICINE 19 10599976 10599976 C T 19:g.10599976C>T ENST00000171111.5:c.1600G>A 334 5/6 0.0000556895 rs774683169 Prostate Cancer (DKFZ, Cancer Cell 2018) ICGC_PCA101_T01 Prostate A321V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.14;Polyphen-2: impact: benign, score: 0.015 Missense_Mutation SNP NA NA NA 19 10602616 10602616 G A 19:g.10602616G>A ENST00000171111.5:c.962C>T 25 3/6 Esophageal Squamous Cell Carcinoma (ICGC, Nature 2014) ESCC-212T Esophageal Squamous Cell Carcinoma L237M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: probably_damaging, score: 0.966 Missense_Mutation SNP 1 Somatic NA BGI 19 10602869 10602869 G T 19:g.10602869G>T ENST00000171111.5:c.709C>A 0.12 6 45 45 40 3/6 Esophageal Squamous Cell Carcinoma (ICGC, Nature 2014) ESCC-216T Esophageal Squamous Cell Carcinoma Y572C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0;Polyphen-2: impact: possibly_damaging, score: 0.782 Missense_Mutation SNP 2 Somatic NA BGI 19 10597488 10597488 T C 19:g.10597488T>C ENST00000171111.5:c.1715A>G 0.36 0.0095 25 44 1 104 72 6/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_1762 Colorectal Adenocarcinoma A30T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.43;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP NA NA dfci.harvard.edu 19 10610622 10610622 C T 19:g.10610622C>T ENST00000171111.5:c.88G>A 940 2/6 0.000016125521053827213 rs537634437 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_1241 Colorectal Adenocarcinoma R269W OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.15;Polyphen-2: impact: possibly_damaging, score: 0.663 Missense_Mutation SNP 1 NA NA dfci.harvard.edu 19 10602773 10602773 G A 19:g.10602773G>A ENST00000171111.5:c.805C>T 1741 3/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_3021 Colorectal Adenocarcinoma T543M OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.23;Polyphen-2: impact: benign, score: 0.285 Missense_Mutation SNP NA NA dfci.harvard.edu 19 10599948 10599948 G A 19:g.10599948G>A ENST00000171111.5:c.1628C>T 2248 5/6 0.000007959121948655732 rs111830952 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_335135 Colorectal Adenocarcinoma R261Q OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.62;Polyphen-2: impact: benign, score: 0.058 Missense_Mutation SNP 1 NA NA dfci.harvard.edu 19 10602796 10602796 C T 19:g.10602796C>T ENST00000171111.5:c.782G>A 4117 3/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_335135 Colorectal Adenocarcinoma A266V OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.29;Polyphen-2: impact: benign, score: 0.37 Missense_Mutation SNP NA NA dfci.harvard.edu 19 10602781 10602781 G A 19:g.10602781G>A ENST00000171111.5:c.797C>T 4117 3/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_112 Colorectal Adenocarcinoma L231I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: benign, score: 0.185 Missense_Mutation SNP 1 NA NA dfci.harvard.edu 19 10602887 10602887 G T 19:g.10602887G>T ENST00000171111.5:c.691C>A 1196 3/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_1241 Colorectal Adenocarcinoma V561I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.04;Polyphen-2: impact: benign, score: 0.23 Missense_Mutation SNP NA NA dfci.harvard.edu 19 10599895 10599895 C T 19:g.10599895C>T ENST00000171111.5:c.1681G>A 1741 5/6 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016_3611 Colorectal Adenocarcinoma F262L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.77;Polyphen-2: impact: benign, score: 0 Missense_Mutation SNP NA NA dfci.harvard.edu 19 10602792 10602792 G T 19:g.10602792G>T ENST00000171111.5:c.786C>A 1253 3/6 Ampullary Carcinoma (Baylor College of Medicine, Cell Reports 2016) CAC_3117 Ampullary Carcinoma R135H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP Somatic Untested Baylor College of Medicine 19 10610306 10610306 C T 19:g.10610306C>T ENST00000171111.5:c.404G>A 0.19 27 113 193 2626 2/6 Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) 01-087MM_BONE Prostate Adenocarcinoma R135C OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.01;Polyphen-2: impact: probably_damaging, score: 0.989 Missense_Mutation SNP diploid NA NA fhcrc 19 10610307 10610307 G A 19:g.10610307G>A ENST00000171111.5:c.403C>T 0.16 4 21 44 2/6 Sarcoma (TCGA, PanCancer Atlas) TCGA-QQ-A8VF-01 Leiomyosarcoma R240H OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.17;Polyphen-2: impact: probably_damaging, score: 0.959 Missense_Mutation SNP shallowdel . . . 19 10602859 10602859 C T 19:g.10602859C>T ENST00000171111.5:c.719G>A 0.45 15 18 34 747 3/6 0.000011944767394048005 rs535659039 Bladder Urothelial Carcinoma (DFCI/MSKCC, Cancer Discov 2014) MSKCC-0820_NR Bladder Urothelial Carcinoma R565T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.03;Polyphen-2: impact: benign, score: 0.061 Missense_Mutation SNP NA NA NA 19 10599882 10599882 C G 19:g.10599882C>G ENST00000171111.5:c.1694G>C 80 5/6 Bladder Urothelial Carcinoma (DFCI/MSKCC, Cancer Discov 2014) MSKCC-0820_NR Bladder Urothelial Carcinoma M499I OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.035 Missense_Mutation SNP NA NA NA 19 10600358 10600358 C G 19:g.10600358C>G ENST00000171111.5:c.1497G>C 80 4/6 Skin Cutaneous Melanoma(Broad, Cancer Discov 2014) Pat_16_Pre Melanoma L153F OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: probably_damaging, score: 0.947 Missense_Mutation SNP NA NA broad.mit.edu 19 10610253 10610253 G A 19:g.10610253G>A ENST00000171111.5:c.457C>T 0.02 4 218 743 2/6 Breast Cancer (MSKCC, NPJ Breast Cancer 2019) s_DS_bkm_082_T Invasive Breast Carcinoma A91T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.41;Polyphen-2: impact: benign, score: 0.039 Missense_Mutation SNP diploid 1 SOMATIC_VS_POOL NA MSK-IMPACT341 19 10610439 10610439 C T 19:g.10610439C>T ENST00000171111.5:c.271G>A 0.44 0.0006 246 310 1 1752 10 2/6 0.0002906444342475315 rs202181679 Breast Cancer (MSKCC, NPJ Breast Cancer 2019) s_DS_bkm_010_T Invasive Breast Carcinoma Q620del OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: NA;Polyphen-2: NA In_Frame_Del DEL diploid SOMATIC_VS_POOL NA MSK-IMPACT 19 10597343 10597345 CTG - 19:g.10597343_10597345del ENST00000171111.5:c.1858_1860del 0.44 291 376 778 7 6/6 0.002394384133164424 Metastatic Melanoma (MSKCC, JCO Precis Oncol 2017) DS-vem-29-T Cutaneous Melanoma P549L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: deleterious, score: 0.02;Polyphen-2: impact: benign, score: 0.056 Missense_Mutation SNP NA NA BergerLab 19 10599930 10599930 G A 19:g.10599930G>A ENST00000171111.5:c.1646C>T 30 5/6 0.000039826 rs756346136 Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) MM18T Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor D236N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.06;Polyphen-2: impact: benign, score: 0.048 Missense_Mutation SNP 4 NA NA John Hopkins 19 10602872 10602872 C T 19:g.10602872C>T ENST00000171111.5:c.706G>A 5596 3/6 Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) MM12T Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor A407T OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.12;Polyphen-2: impact: benign, score: 0.007 Missense_Mutation SNP 1 NA NA John Hopkins 19 10602359 10602359 C T 19:g.10602359C>T ENST00000171111.5:c.1219G>A 5500 3/6 0.000009693491788116024 rs542047862 Upper Tract Urothelial Cancer (MSK, Eur Urol 2015) DS-uttcc-060-P Upper Tract Urothelial Carcinoma D585N OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.3;Polyphen-2: impact: benign, score: 0.059 Missense_Mutation SNP diploid Somatic high mskcc.org 19 10597450 10597450 C T 19:g.10597450C>T ENST00000171111.5:c.1753G>A 0.39 0.02 221 340 5 216 422 6/6 0.0000358143 rs200652594 Bladder Cancer (MSKCC, Eur Urol 2014) DS-bla-080 Bladder Urothelial Carcinoma S275L OncoKB: Unknown, level NA;CIViC: NA;MyCancerGenome: not present;CancerHotspot: no;3DHotspot: no MutationAssessor: NA;SIFT: impact: tolerated, score: 0.64;Polyphen-2: impact: benign, score: 0.086 Missense_Mutation SNP shallowdel Somatic high mskcc.org 19 10602754 10602754 G A 19:g.10602754G>A ENST00000171111.5:c.824C>T 0.08 75 893 725 33 3/6