Protein Change V155F V155F V155F V155F V155A V155F R320L G417V R260Q G333C G333C G333C G480W G480W G480W R470C R470C R320L R320L R320L R272C R272C R260L R260L R272P R272H R601W R320Q G417V G417V R272L M110V M110V R601L R601L R601L R601L G480V M110I M110I G333F R260Q G333S R260L M110I R272P R272H R320M R320P R601W M110L G333C G480W R470C R470C R320L R320Q R320Q R272L R470C R470C R470C R470C R470C R601W R601W R601W R601W R601W G480W R470C R470C R470C R272C R470H R260Q R320W R601W R470C G417W R272C R601L G333C G480W G480W R470C R260L G333S G333S R470S G417R G417E R320W G417V G417V M110V G417W G333D R415C G379D G430C G430C G430C R415H R415H R415H G379V G379D R415C R415H G430V S243F Q530* E121* Q74Hfs*77 G186C Q227* G186S R260* X511_splice E449* D422N D422N E444* E441* E441* V420Sfs*38 V420Sfs*38 K97* E542Dfs*31 R336* Q82* A356Gfs*55 G570* G570* M409* M409* M409* H424Qfs*15 D529Pfs*44 I500Mfs*3 W352* E258* E258* M550* M550* K323Rfs*5 A331Kfs*14 S224Pfs*123 E535* R601* G186C G186C E198* F546Lfs*2 F478Lfs*22 G186V E192* W591* R296Afs*21 Q402* T43Sfs*35 W403* R296Afs*9 I566Tfs*28 R272Lfs*77 V152Pfs*21 X442_splice K216* E213* G332Dfs*64 R413Vfs*45 G332Afs*68 A95Pfs*62 S338F G433Afs*25 D422H Y491* X566_splice N238Rfs*33 S21* X511_splice E307* X214_splice V547Rfs*27 M147_E149delinsIG* X570_splice C518_Y520delinsGV* Y567* E496* I137Mfs*33 Q530* V167Lfs*63 S391Afs*9 D422Y D422Y L291Cfs*26 D589Rfs*30 E57* R565* K108Rfs*49 Y396* Y396* E134Rfs*5 E69* Y584* X511_splice V420Gfs*25 E542* G333Lfs*16 E121* Y396* X511_splice G186F M550Ifs*24 E446* E138* R596* R296Qfs*52 E117* F546* L56Wfs*12 E444* Y584* Q178* T588Yfs*31 T314Rfs*3 X511_splice Q284* S338L V302Gfs*48 I566Tfs*28 N469Kfs*11 S243C G423V Q75* G186S S338L P318Rfs*10 E593* E593* E593* E593* L281Rfs*36 L281Rfs*36 L281Rfs*36 L281Rfs*36 M209Sfs*21 M209Sfs*21 M209Sfs*21 M209Sfs*21 M209Sfs*21 M209Sfs*21 M209Sfs*21 M209Sfs*21 M409* M409* M409* M409* Y537Afs*12 X570_splice G186S K97* L355Sfs*37 G127Vfs*30 I519Mfs*12 D256Vfs*95 S243F E134* C23Y E126* R260* R507* E542Dfs*31 E593* X442_splice Y396Sfs*19 T330Rfs*19 R269Gfs*8 L374* R459* K323Rfs*5 Y85Lfs*41 E37* L471Sfs*9 M409* D422N I519Yfs*8 S338L W450* R554* X570_splice E449* Q46* X570_splice G477Afs*23 G423V E593Rfs*2 X570_splice L175Wfs*55 C613Afs*59 Q193* E441* X570_splice R459Pfs*39 E41* K287* P492Qfs*8 Q201* E540Rfs*32 V604Wfs*68 Y345* I500Tfs*4 K323* V123Rfs*31 Q20* C249Y E449* S592* R336* F478Lfs*2 ZNF599-KEAP1 fusion DNAH1-KEAP1 fusion KEAP1-AP1M2 THRAP3-KEAP1 TYK2-KEAP1 KEAP1-EYA2 KEAP1-intragenic KEAP1-intragenic G364V E488K D479H E488K E488K G364C G364C G364C V167F M550I D165N I461M G509E E488V I461F D479Y G476K G523V G523V G509A G364F M550I G364C G477S V167F I145M D479H D479H D479H D479H D479H D479H Y525C G429D A159T D165N I145F Y525C G429S E488K G509W G476V V475L R460S R169C E488D G509R V167I G509W G476V I145F D479G R460G F139L I461V A159P G429V G509V A159S G523E G527V G527C D165N N485S D479H R459Q V475L C613R E218V R116W C171F T277M N238S G558W L471V N189K M503V E289D R362Q T598I T400S N397S D236N V568F G332S T277M D294V V98A A109T H210D T543M Q620del Q620del Q620del Q620del Q620del Q620del Q620del Q620del F211S A407V R354L A95T D585N V369A W544R M409T V271M V264I R413H V152A T142M R234P C196F D236N L237M Y572C E149K A30T H311R G603W R71L D389Y G419W P278S R204P S102L S102L S102L A95T A95T R116P P318L S275L I425M N382K P313A R507L R362Q R362Q R362Q R362Q V271M G332C G332C G332C C171F R234W H274R V123L W591L W591L E219Q P130L P130L R269W R269W R413H D585N A63V R336Q R261W R261W R15Q S103F A184T G558R G558R G511S E192K E192K E192K G571R G603V G603V G603V A556T L291M E117D E117D E117D T36A D448G M133R R596Q V132G S224F R447W R483H P361L P361L P361L T112S E219K E219K M156T R6W A392P E25Q V99M S431F S431F I416F V606M V168F G464V W403C W403C L339F E493K V568F A510V R413L R413L G511C G605R H311Y E219S W450R D236V D236V M161I M456K C273S M67I W252L W252L G195R H96R Q82P C257Y F335V I187N N504S M161V P130T S144Y V369A L153F L153F G332S A91T C288F G462W A191P Y33C Y334dup R296C R296C T314_P322del A321V N68S G433S G433S A91S A63D V83F D579N N183H A321_P322delinsPS E542N C368Y C368F A321T R362P V98G E493A P492S R269L K254R Q563R G378C G378C F211L A427D L153dup R135L D389G Q528P N157K M399I M399I T277M N414I A474V E205V S555C M610I W403L I304N A331P I125F D236Y T51S Y584C D294V Y263_V264delinsF H274L G419V E149Q N238D I207S R204G F52L G48D R483S L281M G127A T314M T142A G127D T330I E493Q L353P G212E E496K F211I E244Q D579Y K254T E542K V271L P278Q E205K M597I V316_M317del G603W R71L Y141F E611D N397del H96L D389Y G419W P278R T142M A191D C613F G158R E242A R554Q R554Q S103Y R71L E117K L310P I506V V418L L231V W544C V369L S224Y E493V R362Q D235Y V271L D589_T590del C171F R234W N482_R483delinsS H274R T314K Q163K P612L R135H R135H H59R W591L L115Q F220L H274Q E307K D587G S224F S224F S224F S555I S555I S555I F107I F107I F107I C77G C77G C77G D236N S45F E25K E218Q E244K R116P L471F I137T V271L L115Q P278L P89L S592G N157S S104R H311L V168G V152G R135H P130L W544L H225N E218D E441D G564W R413S T543M A188G G433D S431F I125V M503I T80I S8N S45F T598A D29H S45Y Q178L S103Y A607P C319F I425M R234W P278L V239M I519M E218K Q177H E149K I137T Y520C R116L L153V V465M V324M V271L R71Q D585N G433S E593K V152N R554Q L472F A270V R354W I137T V99L V271M S431F G195V G195C Q620H G564V R483P C297Y R234P C196F A40V A191T A95V G332C P412T G564E Y443H A266T F262L M161I D236N R50H I185T R326H A95T R261Q V152A A91T R483C V98A A109T P492R G332D R553Q Y345H A392T M499I R554Q T142M D236N G603W G524C F246L S144F S144F P278S Q284L Q284L M503K L268P R261P A191T V99L E218V R204P W497L E117K W252C F280Y L100P S102L V271M V271L V271L A101G G332C L199F K97N R116W Y162C Q616H D235H V123L V214L G558E E219Q V79L G571D G511C M156V Q163H Q92K A95V G11R Y300C A356V P412T D448V A34T S45F Y537H R50H V214M H311R T541I C288R K84N A95V Y300_L301del R234W D538N V534M A321V L237M Y572C A30T R269W T543M R261Q A266V L231I V561I F262L R135H R135C R240H R565T M499I L153F A91T Q620del P549L D236N A407T D585N S275L