PSIBLAST 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Stephen F.
Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005)
"Protein database searches using compositionally adjusted
substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: uniprot_sprot.fasta
571,282 sequences; 206,678,396 total letters
Results from round 1
Query= sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens
OX=9606 GN=VPS39 PE=1 SV=2
Length=886
Score E
Sequences producing significant alignments: (Bits) Value
sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens OX=... 1827 0.0
sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein OS=Mus musculus OX=... 1788 0.0
sp|Q1ZXS5|VPS39_CAEEL Vacuolar protein sorting-associated protein... 403 4e-125
sp|Q8L5Y0|VPS39_ARATH Vacuolar sorting protein 39 OS=Arabidopsis ... 285 4e-81
sp|O13955|VAM6_SCHPO Vacuolar morphogenesis protein 6 OS=Schizosa... 210 2e-55
sp|Q8WUH2|TGFA1_HUMAN Transforming growth factor-beta receptor-as... 203 3e-53
sp|Q3UR70|TGFA1_MOUSE Transforming growth factor-beta receptor-as... 197 3e-51
sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-as... 196 1e-50
sp|A7MB11|TGFA1_BOVIN Transforming growth factor-beta receptor-as... 192 2e-49
sp|Q07468|VAM6_YEAST Vacuolar morphogenesis protein 6 OS=Saccharo... 131 6e-30
sp|F4I312|VPS3_ARATH Vacuolar sorting protein 3 OS=Arabidopsis th... 103 3e-21
sp|Q54EH3|Y1510_DICDI GTPase-activating protein DDB_G0291510 OS=D... 61.6 3e-08
sp|Q7TT50|MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta O... 47.0 9e-04
sp|P53046|ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS=Saccharom... 46.6 0.001
sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta O... 46.2 0.002
sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS=... 43.1 0.013
sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS=... 42.7 0.016
sp|Q7TT49|MRCKB_RAT Serine/threonine-protein kinase MRCK beta OS=... 42.4 0.027
sp|Q9Y7U6|RGF1_SCHPO Rho1 guanine nucleotide exchange factor 1 OS... 41.2 0.049
sp|Q9UTR5|RGF2_SCHPO Rho1 guanine nucleotide exchange factor 2 OS... 41.2 0.050
sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kina... 40.0 0.12
sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus OX=... 40.0 0.12
sp|F1LP90|MINK1_RAT Misshapen-like kinase 1 OS=Rattus norvegicus ... 39.7 0.16
sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens OX=... 39.7 0.18
sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase kina... 39.3 0.18
sp|P93043|VPS41_ARATH Vacuolar protein sorting-associated protein... 38.5 0.35
sp|Q5VT25|MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha ... 38.1 0.44
sp|P51862|ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS=Saccharom... 37.0 1.1
sp|A5PF44|GARL3_DANRE GTPase-activating Rap/Ran-GAP domain-like p... 36.6 1.4
sp|Q8IVF5|TIAM2_HUMAN Rho guanine nucleotide exchange factor TIAM... 36.6 1.5
sp|Q3UU96|MRCKA_MOUSE Serine/threonine-protein kinase MRCK alpha ... 36.2 1.8
sp|O54874|MRCKA_RAT Serine/threonine-protein kinase MRCK alpha OS... 35.8 2.6
sp|Q6ZPF3|TIAM2_MOUSE Rho guanine nucleotide exchange factor TIAM... 35.8 2.7
sp|Q502L7|KAD8_DANRE Adenylate kinase 8 OS=Danio rerio OX=7955 GN... 35.0 3.2
sp|P93231|VPS41_SOLLC Vacuolar protein sorting-associated protein... 33.9 9.5
>sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens
OX=9606 GN=VPS39 PE=1 SV=2
Length=886
Score = 1827 bits (4732), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 886/886 (100%), Positives = 886/886 (100%), Gaps = 0/886 (0%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
Sbjct 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
Query 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
Sbjct 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
Sbjct 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
Query 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
Sbjct 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
Query 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
Sbjct 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
Query 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
Sbjct 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
Query 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
Sbjct 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
Sbjct 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
Sbjct 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
Query 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
Sbjct 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
Query 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
Sbjct 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
Query 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
Sbjct 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
Query 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
Sbjct 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
Query 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
Sbjct 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
Query 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
Sbjct 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
>sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein OS=Mus musculus
OX=10090 GN=Vps39 PE=1 SV=1
Length=886
Score = 1788 bits (4630), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 863/886 (97%), Positives = 877/886 (99%), Gaps = 0/886 (0%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
Sbjct 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
Query 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
Sbjct 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
TCDLQHTETGEEVLRMCVAV+KKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
Sbjct 121 TCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
Query 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
Sbjct 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
Query 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
LNWTDIPVAMEHQPPYI+AVLPRYVEIRT EPRLLVQSIELQRPRFITSGGSNIIYVASN
Sbjct 241 LNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
Query 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
Sbjct 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
Query 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLP LSGAELEKAHLALIDYL
Sbjct 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYL 420
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
Sbjct 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
Sbjct 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
Query 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVL FLIENFK LA
Sbjct 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALA 600
Query 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
IPYLEHIIHVWEETGS+FHNCLIQLYCEKVQ LMK+YLLS P GK+PVPAGEE GELGEY
Sbjct 601 IPYLEHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEY 660
Query 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
RQKLLMFLEISS+YDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVH+LKDT+MA+
Sbjct 661 RQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAK 720
Query 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
EYCHKHYD+NK+GNKDVYLSLLRMYLSPPSIHCLGPIKLELLEP+ANLQAALQVLELH+S
Sbjct 721 EYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYS 780
Query 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
KLDTTKA+NLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
Sbjct 781 KLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
Query 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVN ADT
Sbjct 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT 886
>sp|Q1ZXS5|VPS39_CAEEL Vacuolar protein sorting-associated protein
39 homolog OS=Caenorhabditis elegans OX=6239 GN=vps-39
PE=1 SV=1
Length=926
Score = 403 bits (1036), Expect = 4e-125, Method: Compositional matrix adjust.
Identities = 290/943 (31%), Positives = 481/943 (51%), Gaps = 93/943 (10%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWE--EWLLVGTKQGHLLLYRIRKDVVPADVASPESGS 58
M+DA+ P + +LP+++ CLA E + LL G + GHL Y I S
Sbjct 1 MYDAYTPCEVALRLPVEVTCLAFQESNQTLLAGGRAGHLYAYTI---------------S 45
Query 59 CNRFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLT--FQQITTVSKAK 115
NR L K+F KK + ++ V + +L+ + + + H L ++ T + K K
Sbjct 46 ANRRGFELTNICKSFHKKAVMELKVCQREDLLLCVSDGQLMAHKLSDPEYKVETLIHKVK 105
Query 116 GASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR----EFHELQGDFS--VPDVPKS 169
F +G+ L + V+ +KKL L+ W ++ EF E+ D++ D P S
Sbjct 106 PVQTF-ARFSPKTSGD--LYVIVSSRKKLYLFKWGEKDGHKEFIEVALDYNPVFLDTPTS 162
Query 170 MAWCENSICVGFKRDYYLIRVD--------GKGSIKEL---FPT---GKQLEPLVAPLAD 215
+ + + +Y+ + + +GS E F T +P + P+ D
Sbjct 163 IRCVGEMVFFSVRNEYFSMTMQKDKTTTSPSEGSTPEGWNGFVTRLLNFNCQPGIVPMID 222
Query 216 GK-VAVGQDDLTVVLNEEGICTQKCA------LNWTDIPVAMEHQPPYIIAVLPR-YVEI 267
+ VA ++++ V + I Q+ A ++++P+ + + PY++ +L + VE+
Sbjct 223 RRRVAFVRNEIVVTTD---IWGQRPANVLSDEYKFSEVPMQIVYDSPYLVGMLSKGRVEV 279
Query 268 RTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRL-IPVPMATQIQQLLQDKQFEL 326
R+ LVQ++ L + + SG ++VA+ +W L + + L+Q++ FEL
Sbjct 280 RSIFDGQLVQTMSLPKAMTLCSGARGQVFVAALSDIWILDTSQNLRKNVSHLIQERHFEL 339
Query 327 ALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMG---LY 383
A+QLAE +S+ ++Q IK A NLF QK+FDES +F ++ TD + V+ ++
Sbjct 340 AIQLAE---NSNLFAEEQKLEIKKKAALNLFNQKKFDESFALFGEIKTDISEVLSIIRMF 396
Query 384 PDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPL 443
P+LLP ++ + +P + +A LAL YL++ R++ K + + S+
Sbjct 397 PELLPDGFQSMTGVVSDMP---ANDRMRALLALGSYLSEIRTEHAKHIELYNRLYSSGAA 453
Query 444 MEGTPTIKSKKKL-LQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKY 502
+ K+K L L+++DTTLLKCY+ T LV L+RL++N C E+++ +L+ +
Sbjct 454 KKTDEDEKAKLLLTLRVVDTTLLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRL 513
Query 503 SELIILYEKKGLHEKALQVLVDQSKKANS-PL--KGHERTVQYLQHLGTENLHLIFSYSV 559
L ILYE + HE AL + +DQS + ++ P ++ V+YLQ LG NL LI Y+
Sbjct 514 RSLFILYETRKKHEMALDLFIDQSSRPDADPFFDDAIQQIVEYLQSLGNSNLPLILKYAK 573
Query 560 WVLRDFPEDGLKIFTEDLPEV-ESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRF 618
WVL E G++IFT D E+ +L R V+ FL IPYLEH+I WEE S F
Sbjct 574 WVLAKNLEAGVQIFTSDETEMARNLNRKAVVEFLKSECPDALIPYLEHVIFKWEEPSSYF 633
Query 619 HNCLIQLYCEKVQGLMKEYLLSFP---AGKTPVPAGEEEGELGEYRQKLLMFLEISSYYD 675
H L++ Y +V L K+Y+ +FP + + AG+E+GELG YR++LL FLE+S Y
Sbjct 634 HETLLEFYVARVNTLFKDYVHAFPDAFSDENITRAGDEDGELGLYRKRLLKFLEVSHSYS 693
Query 676 PGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNK 735
P ++ EERAL+LGR+ +HEQAL IYV+ LK+ AEEYC +Y+ + + N
Sbjct 694 PQTVLLQLAPHAFYEERALILGRLKQHEQALAIYVNTLKNVPAAEEYCRLYYNAHDETNS 753
Query 736 DVYLSLLRMYLSP--PSIHCL---------GPIKLELLEPKA----------NLQAALQV 774
VYL L R + P +H + G + ++ E ++ A+++
Sbjct 754 QVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTSSYQPDVNTAIKI 813
Query 775 LELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQE 834
L H K+DT ALN+LPA T + + + V++ ++ ++ K++ + E
Sbjct 814 LAKHADKIDTVGALNMLPATTPLRVVFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLE 873
Query 835 ERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
+ Q K I+ C+VC+KKI SAF RYP+G + H +C
Sbjct 874 RKNKAQSTKIIVNFSSECVVCEKKIAVSAFVRYPDGRLAHLYC 916
>sp|Q8L5Y0|VPS39_ARATH Vacuolar sorting protein 39 OS=Arabidopsis
thaliana OX=3702 GN=VPS39 PE=1 SV=1
Length=1000
Score = 285 bits (730), Expect = 4e-81, Method: Compositional matrix adjust.
Identities = 265/1014 (26%), Positives = 465/1014 (46%), Gaps = 165/1014 (16%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
+H+A++ +L+ P +ID + ++ L G G L +Y P + ++ + +
Sbjct 2 VHNAYDSFQLLKDCPARIDAVESYGSKLFAGCYDGSLRIYS------PPESSASDPSELH 55
Query 61 RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASL 119
+ LEK+ FSKK I + V++ ++L+SL E+ I H L + + ++KAKGA+
Sbjct 56 QETYVLEKTVAGFSKKPIVAMEVLASRELLLSLSES-IAFHGLPNLETVAVITKAKGANA 114
Query 120 FTCDLQHTETGEEVLRMCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSIC 178
++ D + +C + +K++ ++ F E++ D+ VPD KS++WC +IC
Sbjct 115 YSWDDRRG-------FLCFSRQKRVCVFKHDGGGGFVEVR-DYGVPDTVKSISWCGENIC 166
Query 179 VGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQK 238
+G K++Y ++ G++ E+FP+G+ PLV L G++ +G++++ V +++ G Q
Sbjct 167 LGIKKEYVILNT-ANGTLSEVFPSGRVAPPLVISLPSGELILGKENIGVFVDQNGKLLQT 225
Query 239 CALNWTDIPVAMEHQPPYIIAVLPRYVEIRTF-EPRLLVQSIELQRPRFITSGGSNIIYV 297
+ W++ P ++ Q PY IA+LPR VE+R P L+Q+I LQ R + +N + V
Sbjct 226 ERICWSEAPTSIVIQNPYAIALLPRRVEVRLLRSPYPLIQTIVLQNIRRLVK-SNNAVIV 284
Query 298 ASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAE-MKDDSDSEKQQQIHHIKNLYAFNL 356
++ V+ L PV + QI QL FE AL L + + D S + + I +A L
Sbjct 285 GLDNSVYVLFPVSIGAQIVQLTASGNFEEALALCKVLPPDESSLRAAKESSIHTRFAHYL 344
Query 357 FCQKRFDESMQVFAKLGTDPTHVMGLYPDLL--------------------------PTD 390
F ++E+M+ F D THV+ +YP ++ +
Sbjct 345 FENGSYEEAMEHFLASQVDITHVLSMYPSIILPKTTIIPQPDKMVDISGDEASLSRGSSG 404
Query 391 YRKQLQYPNP---LPVLSGAELEK---AH---LALIDYLTQKRSQLVKKLNDSDHQSSTS 441
++ +P L A+LE +H +ALI YL ++R +++K + S
Sbjct 405 ISDDMESSSPRYFLESEDNADLESKKMSHNTLMALIKYLLKRRPAVIEKATSEGTEEVIS 464
Query 442 PLMEGT-------------------PTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRL 482
+ T P +++ I+DT LL+ LHT + A L
Sbjct 465 DAVGKTYGANDSSKSKKSSKGRGMIPLNSGAREMAAILDTALLQALLHTGQSGAAIELLK 524
Query 483 ENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVL--------VDQSKKANSPLK 534
N+ ++ E +L K+ YS L+ L++ +H +AL++L +QS+ + +
Sbjct 525 GVNYSDVKICEEILMKSKNYSALLELFKSNSMHHEALKLLNQLADESKTNQSQTDVTQIF 584
Query 535 GHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIE 594
E ++YL+ L + L+ YS+ VL P + +F ++ D V +L +
Sbjct 585 SPELIIEYLKPLCRTDPMLVLEYSMLVLESCPTQTIDLFLSG-----NISADLVNSYLKQ 639
Query 595 NFKGLAIPYLEHIIHVWEETGS-RFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653
+ + YLE ++ + + S N ++Q+Y +V L A K+ +E
Sbjct 640 HAPNMQGRYLELMMAMNDTAVSGNLQNEMVQIYLSEV--------LDLYAAKSAQQKWDE 691
Query 654 EGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHIL 713
+ E R+KLL LE S Y P L+ P D L EERA++LG+M +HE AL IYVH L
Sbjct 692 KDHPPE-RKKLLSALESISGYSPQPLLKRLPRDALYEERAVILGKMNQHELALSIYVHKL 750
Query 714 KDTRMAEEYCHKHYDR-----NKDGNKDVYLSLLRMYLSPPS--------IHCLGPIKL- 759
+A YC + Y+ + + ++YL++L++YL+P I LG +
Sbjct 751 HAPDLALAYCDRIYESVTYLPSGKPSSNIYLTVLQIYLNPKKSAKDFAKRIVALGSFESS 810
Query 760 -------ELLEPKANLQAALQVLELH---------HSKLDTTKALNLLPANTQINDIRIF 803
+L KA + +++ + S D+ ++ + D +
Sbjct 811 DTTKMMDSVLSSKAKGGRSKKIVAIEGAEDMRVGLSSSTDSGRSDVDTEEPLEEGDSTVM 870
Query 804 LEKVLEENAQK-KRFN--QVLK---------NLLH--AEFLRVQEE--------RILHQQ 841
+ +VL+ +Q+ +R N Q LK NLL A LR E + L Q
Sbjct 871 ISEVLDLLSQRWERINGAQALKLLPRETKLHNLLPFLAPLLRNSSEAHRNFSVIKSLRQS 930
Query 842 VKCIITEE--------------KVCMVCKKKIGNSAFARYPNG-VVVHYFCSKE 880
+ EE +C +C KKIG S FA YPNG +VH+ C ++
Sbjct 931 ENLQVKEELYKHRKGVAQVTSESMCSLCNKKIGTSVFAVYPNGKTLVHFVCFRD 984
>sp|O13955|VAM6_SCHPO Vacuolar morphogenesis protein 6 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=vam6
PE=3 SV=1
Length=905
Score = 210 bits (534), Expect = 2e-55, Method: Compositional matrix adjust.
Identities = 234/960 (24%), Positives = 412/960 (43%), Gaps = 147/960 (15%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MH AF +LE +++C+ + V G L Y+I + E
Sbjct 1 MHRAFSLYRVLELSKARVECVFELGGLVYVSNSNGDLDSYKIYNN---------EEEEAA 51
Query 61 RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTV-SKAKGAS 118
F + NF+KK I ++ + I +L ++ +YV+ + TF+++ + + +
Sbjct 52 DFVMEHVDVYPNFTKKPITKVVSCATQDIFYALSDSQVYVYQISTFKKLFSFGAHCQNMC 111
Query 119 LFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS-I 177
L+ G+E++ ++ KK L++Y + L S+ D P+S+AW + I
Sbjct 112 LY---------GDELI--VLSSKKNLEIYEIQKNSKPNLTKTISLNDRPRSLAWVSPTMI 160
Query 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQLEPL-----------------VAPLADGKVAV 220
V D+ + + I L +Q L + ++D +V +
Sbjct 161 LVSLSNDFCAVNTE-TSRISSLNLAWQQSSSLGLGISYIGMSIKSNKLHITRISDDEVLL 219
Query 221 GQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIE 280
+D +++N + + + L W +P A+ + PYII + +Y+ I E ++Q I
Sbjct 220 SKDSQGLLVNLKSLQVSRNPLRWPTVPQAVIYNSPYIITLHNQYIYIWNKETYAMIQQIG 279
Query 281 LQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQ-LAEMKDDSDS 339
+ S N + SN +VW L P + QI+ LL + A+ L+++
Sbjct 280 ISNIYSTFSCHKNTFF-TSNSYVWILTPEDFSNQIEALLNTENLNEAISVLSQITVSQFP 338
Query 340 EKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPN 399
++ + K A F +D +M++F+++ P+ V+GL+P LL +Y + +
Sbjct 339 KRDYYLRITKREKALRSFSSGDYDLAMRLFSEISESPSTVLGLFPGLLDNNYSDAISILS 398
Query 400 PLP---------------------------VLSGAELEKAHLALIDYLTQKRSQLVKKLN 432
P +S K +L YLT R + + L+
Sbjct 399 MAPSQNESIESNVLFPGNHSNSQTDLRNGDAVSTVANNKRLRSLSTYLTDSRRKANRFLS 458
Query 433 -DSDHQ--SSTSPLMEGTPTIKSKKKLLQI---IDTTLLKCYLHTNVALVAPLLRLENNH 486
D +H + + T+ +K+KL +I IDTTL Y+ ++ ALV LLRL N
Sbjct 459 YDEEHYFLQKKNLFLNADGTLVAKEKLEKIAVQIDTTLFLIYMISSPALVGSLLRLPN-R 517
Query 487 CHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSP-----LKGHERT-- 539
C E L A Y EL+ Y K LHE AL +L +K + P LKG T
Sbjct 518 CETSVVETNLLSAKMYRELVEYYYGKSLHEAALDLL---TKLCDEPTDTLSLKGKSNTTS 574
Query 540 -----VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIE 594
+ YL+ L E HLIF YS L + P++ + IF ++ E ++ + VL +L
Sbjct 575 KYEPILSYLEKLSPELDHLIFKYSRVPLSEDPQNSIVIFIDENSEASTISKGVVLKYLET 634
Query 595 NFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEE 654
++I YLE ++ + + F L LY +++ L E F + +
Sbjct 635 ISYKVSIIYLEKLLLDNKFNDTVFPTRLALLYLKRILEL--EETTDF----------KNQ 682
Query 655 GELGEYRQKLLMFLEISSYYDPGRLICDFPF-DGLLEERALLL-GRMGKHEQALFIYVHI 712
+ +KL +L S YD ++ + D L +++L R+ +H+ AL +Y+ I
Sbjct 683 EVFKQTIEKLEDYLTNSKQYDANVVLQEINSQDEFLSTVSIILYRRLSRHQDALDVYLKI 742
Query 713 LKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQA-A 771
L D A YC+ Y + DG + Y LL E N ++ +
Sbjct 743 LNDWEGALSYCNSVY--SIDGETEPYYMLLA-------------------EISKNYKSGS 781
Query 772 LQVLEL---HHSKLDTTKALNLLPANTQI--------NDIRIFLEKVLEENAQKKRFNQV 820
L +L+ + S+LD + LLP N + + R E++ + Q K + +
Sbjct 782 LNILDFITKYSSRLDLNRVFPLLPKNISMKSYHSLFSSQFRQLFEELSNKETQSKLYQKR 841
Query 821 LKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKE 880
L++L + E +V+ E++ +IT EK C+ C K++G S + +P+G VVHY C+K+
Sbjct 842 LEDL-NEELTKVRSEKV-------VITREKTCLFCHKRLGKSVISIFPDGSVVHYGCAKK 893
>sp|Q8WUH2|TGFA1_HUMAN Transforming growth factor-beta receptor-associated
protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1
SV=1
Length=860
Score = 203 bits (517), Expect = 3e-53, Method: Compositional matrix adjust.
Identities = 223/902 (25%), Positives = 403/902 (45%), Gaps = 95/902 (11%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLE-KSN 70
+K + I+C+ L VGT + + + + VPA A+ F T + + +
Sbjct 21 DKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPAT--------FTATKQLQRH 72
Query 71 KNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETG 130
F K + ++ S L+ L +N+I + ++L + + + ++ KGA+ F +
Sbjct 73 LGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD 132
Query 131 EEVLRMCV-AVKKK-LQLYF-WKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYL 187
+ +C+ +VK++ +Q++ ++DR ++ + S + P ++A + +C+ Y +
Sbjct 133 PFCVEVCIISVKRRTIQMFLVYEDRV--QIVKEVSTAEQPLAVAVDGHFLCLALTTQY-I 189
Query 188 IRVDGKGSIKELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLNEEGICTQKCALNWTD 245
I G ++LFP ++ P+V + + + G L + GI +Q+ ++W++
Sbjct 190 IHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGI-SQRAPVHWSE 248
Query 246 IPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWR 305
+ PY+IA+ ++ + + + Q++ + + +I VA++ V+
Sbjct 249 NVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVI-VATSKGVYI 307
Query 306 LIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL--YAFNLFCQKRFD 363
L+P+P+ QIQ LL ++ E AL LA+ + +++ Q+ + + L F F Q +F
Sbjct 308 LVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFL 367
Query 364 ESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYP--------NPLPVLSGAELEKAHLA 415
E+ ++F D ++ LYP LLPT +P N L ++ K
Sbjct 368 EAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRF 427
Query 416 LIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVAL 475
L+ YL + RS V D IDT LLK Y +
Sbjct 428 LMSYLNEVRSTEVANGYKED------------------------IDTALLKLYAEADHDS 463
Query 476 VAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQSKKAN 530
+ LL EN C + +S L+K KY L +LY A+Q+ V D
Sbjct 464 LLDLLVTEN-FCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTR 522
Query 531 SPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESLPRDR 587
S L +E V +L + E L +++Y+ WVL+ E G+++FT+ D + S D
Sbjct 523 SDL--YEYIVDFLTYCLDEEL--VWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDD 578
Query 588 VLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTP 647
++ L + K L + YLEH++ +H L LY E+V L++
Sbjct 579 IINCLKKYPKAL-VKYLEHLVIDKRLQKEEYHTHLAVLYLEEV--LLQR----------- 624
Query 648 VPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALF 707
A + E E + KL L+ S Y L+ GL E A+L G++G+HE+AL
Sbjct 625 ASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALH 684
Query 708 IYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKA 766
I VH L+D AE+YC R+ + ++ +LL +YL GP EL
Sbjct 685 ILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHA------GPTAHELA---- 734
Query 767 NLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLH 826
AA+ +L H ++ D + L +LP + + FL + ++ +R QV L
Sbjct 735 --VAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLAR 792
Query 827 AEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SKEVNPA 884
+E L +++ + ++++K+C +C+ F RYPNG +VH C S+ NP+
Sbjct 793 SENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPS 852
Query 885 DT 886
+
Sbjct 853 SS 854
>sp|Q3UR70|TGFA1_MOUSE Transforming growth factor-beta receptor-associated
protein 1 OS=Mus musculus OX=10090 GN=Tgfbrap1
PE=1 SV=1
Length=860
Score = 197 bits (502), Expect = 3e-51, Method: Compositional matrix adjust.
Identities = 215/892 (24%), Positives = 388/892 (43%), Gaps = 89/892 (10%)
Query 16 LQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLE-KSNKNFS 74
+ I+C+ L VGT + + + + +P A+ F T + + F
Sbjct 25 ISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTAT--------FVATKQLHRHLGFK 76
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVL 134
K + ++ S L+ L +N+I + ++L + + + ++ KGA+ F + +
Sbjct 77 KPVNELCAASALNRLLVLCDNSITLVNMLNLEPVPSGARIKGATTFAVNESPVNGDPFCV 136
Query 135 RMCV-AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGK 193
+C+ +VK++ F + ++ + S P+ P ++A +C+ Y ++
Sbjct 137 EVCIISVKRRTVQMFLVYEDRVQIVKEVSTPEQPLAVAVDGYFLCLALTTQYIILNY-ST 195
Query 194 GSIKELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME 251
G ++LFP ++ P+V + + + G L + GI +Q+ ++W++ +
Sbjct 196 GLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATVAGI-SQRAPVHWSENVIGAA 254
Query 252 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM 311
PY+IA+ ++ + + + Q++ + + +I VA++ V+ L+P+P+
Sbjct 255 VCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVI-VATSKGVYILVPLPL 313
Query 312 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL--YAFNLFCQKRFDESMQVF 369
QIQ LL +++ E AL LA+ + +++ Q+ + + L F F Q +F E+ ++F
Sbjct 314 EKQIQDLLANRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELF 373
Query 370 AKLGTDPTHVMGLYPDLLPTDYRKQLQYP--------NPLPVLSGAELEKAHLALIDYLT 421
D ++ LYP LLPT +P N L ++ K L+ YL
Sbjct 374 RSSQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEKMAKCKRFLMSYLN 433
Query 422 QKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLR 481
+ RS V D IDT LLK Y + + LL
Sbjct 434 EIRSTEVANGYKED------------------------IDTALLKLYAEADHDSLLDLLV 469
Query 482 LENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQSKKANSPLKGH 536
EN C + +S L+K KY L +LY A+Q+ V D S L +
Sbjct 470 TEN-FCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQLWVNIVNGDIQDSTRSDL--Y 526
Query 537 ERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESLPRDRVLGFLI 593
E V +L + + L +++++ W+L+ E G++IFT+ D + S D ++ L
Sbjct 527 EYIVDFLTYCLDQEL--VWTHADWLLQKSEEIGVQIFTKRPLDEQQQTSFNPDNIISSLK 584
Query 594 ENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653
+ K L + YLEH++ +H L LY E+V + V G +
Sbjct 585 KYPKAL-VKYLEHLVIDRRLQKEEYHTHLAILYLEEVL-------------RQRVSTGGK 630
Query 654 EGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHIL 713
+ E E + KL L+ S Y L GL E A+L G++G+HE+AL I VH +
Sbjct 631 DVEATETQAKLRRLLQKSDLYRVHLLKEKVQGAGLPMESAILHGKLGEHEKALHILVHEM 690
Query 714 KDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAAL 772
D AE+YC + + ++ +LL MYL GP +L AA+
Sbjct 691 GDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRA------GPSAQDLT------VAAV 738
Query 773 QVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRV 832
+L H + D T+ L LLP + + FL + ++ +R QV L +E L
Sbjct 739 DLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSIHARRTTQVALGLAKSENLIY 798
Query 833 QEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPA 884
+++ + ++E ++C +C+ G F RYPNG +VH C+ + A
Sbjct 799 MYDKMKLKGNAVRLSERELCQLCQNPFGEPVFVRYPNGGLVHTHCAASRHTA 850
>sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-associated
protein 1 homolog OS=Danio rerio OX=7955 GN=tgfbrap1
PE=2 SV=1
Length=863
Score = 196 bits (497), Expect = 1e-50, Method: Compositional matrix adjust.
Identities = 215/826 (26%), Positives = 381/826 (46%), Gaps = 74/826 (9%)
Query 72 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQI-TTVSKAKGASLFTCDLQHTETG 130
K + ++ S + L+ L ++ I V D++T + + T +K KG + F C ++ TG
Sbjct 73 GLKKPVVELKAASALERLIVLCDSAITVVDMVTLEPVPTGGAKLKGVTAF-CINENPVTG 131
Query 131 EEV---LRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYL 187
+ + + +A ++ +Q+ + L+ + + P+ P +++ +IC+ Y +
Sbjct 132 DAFCVEMAVVLARRRAVQICTVHEDRVQMLK-EVTTPEQPCALSLDGYNICLALSTQYMI 190
Query 188 IRVDGKGSIKELFPTG-KQLEPLVAPLADGKVAVGQ-DDLTVVLNEEGICTQKCALNWTD 245
+ G+ ++LFP ++ +P+V + + + L + N EGI +Q+ ++W++
Sbjct 191 LNY-STGASQDLFPYDCEERKPIVKRIGREEFLLAAPGGLGMFANAEGI-SQRAPVSWSE 248
Query 246 IPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWR 305
+A PY++A+ +V + + + L Q++ + + + ++ VAS+ V+
Sbjct 249 NVIAAAVCFPYVVALDEGFVTVHSMLDQQLKQTLSFRDGQLLQDFEGKVV-VASSKAVYM 307
Query 306 LIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL--YAFNLFCQKRFD 363
L+P+P+ QIQ LL + E AL L E + +++ QI H + L F F Q +F
Sbjct 308 LVPLPLERQIQDLLASHRVEEALTLTEAAQRNIPKEKYQILHRRILQQAGFIQFGQLQFL 367
Query 364 ESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQK 423
E+ + F K D ++ LYP LLP +P P+ A+L HL D Q+
Sbjct 368 EAKEHFRKGQLDVRELISLYPLLLPASSSFTRCHP---PLHEFADLN--HLTQGD---QE 419
Query 424 RSQLVKK-LNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRL 482
+ Q K+ L H+ +S + G + +DT LLK Y T+ + LL
Sbjct 420 KVQRFKRFLISYLHEVRSSDIANG---------FHEDVDTALLKLYAETSHESLLDLLAS 470
Query 483 ENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHER---- 538
EN C + +S L+K HKY L +LY G ALQ+ V K N L+ R
Sbjct 471 ENA-CLLADSAPWLEKHHKYYALGLLYHYNGQDAAALQMWV---KIVNGDLQDSTRPDLF 526
Query 539 --TVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVE---SLPRDRVLGFLI 593
V +L NL L++ ++ W L+ + G++IFT+ E L D V+ +L
Sbjct 527 EYVVDFLSF--CSNLDLVWRHADWALQKDQKIGVQIFTKRPTSEERRGQLNADDVITYLQ 584
Query 594 ENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653
++ + L + ++ + ++H L LY EKV GL+ P+ E
Sbjct 585 KHSQALLLYLEHLVLEKKLQK-EKYHTHLAVLYAEKVLGLISR------------PSTSE 631
Query 654 EGELGEYRQKLLMFLEISSYYDPGRLICDF-PFDGLLEERALLLGRMGKHEQALFIYVHI 712
E +L RQKL L+ S+ Y L+ + LL ERA L G++ +H++AL + VH
Sbjct 632 E-QLSAARQKLQRLLKESNLYRVQLLLGKIQDSELLLLERATLHGKLEEHDKALHVLVHQ 690
Query 713 LKDTRMAEEYCH-KHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAA 771
LKD+ AEEYC ++ ++++ LL +YL P + A AA
Sbjct 691 LKDSSAAEEYCSWASASQDSSYRQNLFHQLLSVYLDPD------------VPGGAQTVAA 738
Query 772 LQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLR 831
+ +L H D + L LLP + + +R FL + + +QV L A+ L+
Sbjct 739 VDLLNRHAEVFDAVRVLKLLPEDWSLPLLRPFLCGAMRATVHARCTSQVALGLARAQNLQ 798
Query 832 VQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
+ +R+ ++ +++E+K C +C A P G VH C
Sbjct 799 LLHDRLKYRGGPVLVSEKKGCQLCHNTFSEPDCACLPGGTPVHINC 844
>sp|A7MB11|TGFA1_BOVIN Transforming growth factor-beta receptor-associated
protein 1 OS=Bos taurus OX=9913 GN=TGFBRAP1 PE=2
SV=1
Length=859
Score = 192 bits (487), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 221/906 (24%), Positives = 408/906 (45%), Gaps = 85/906 (9%)
Query 4 AFEPVPILEKLPLQID-------CLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPES 56
AF VP +E+ L D C+ L VGT + + + + +P A+
Sbjct 6 AFTLVPAIEREQLLSDRDRGLLECVECCGRNLYVGTSDCFVYHFLLEEKTLPGGSAT--- 62
Query 57 GSCNRFEVTLE-KSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAK 115
F T + + F K + ++ S L+ L + I + +L+ + + + ++ K
Sbjct 63 -----FTATRQLHRHLGFKKAVSELRAASALSRLLVLCDGCISLVHMLSLEPVPSGARIK 117
Query 116 GASLFTCDLQHTETGEEVLRMCV-AVKKK-LQLYF-WKDREFHELQGDFSVPDVPKSMAW 172
GA+ F + + +C+ +VK++ +Q++ ++DR ++ + S P+ P ++A
Sbjct 118 GATAFALNENPVSGDPFCVEVCIISVKRRTIQVFLVYEDRV--QIVREVSTPEQPLAVAV 175
Query 173 CENSICVGFKRDYYLIRVDGKGSIKELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLN 230
+ +C+ Y ++ G+ ++LFP ++ P+V + + + G L +
Sbjct 176 DGHFLCLALTTQYIILNY-STGAAQDLFPFCSEERRPIVKRIGRQEFLLAGPGGLGMFAT 234
Query 231 EEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSG 290
GI +Q+ + W++ + PY++A+ ++ + + + Q++ + +
Sbjct 235 VAGI-SQRAPVRWSENVIGAAVCFPYVVALDDEFITVHSMLDQQQKQTLPFKEGHILQDF 293
Query 291 GSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKN 350
+I VA++ V+ L+P+P+ +IQ LL + E AL LA+ + +++ Q+ + +
Sbjct 294 EGRVI-VATSKGVYILVPLPLEKRIQDLLASHRVEEALVLAKGARRNIPKEKFQVMYRRI 352
Query 351 LY--AFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAE 408
L F F Q +F ++ ++F D ++ LYP LLPT +P P+ A+
Sbjct 353 LLQAGFIQFAQLQFLKAKELFRSGQLDVRELISLYPLLLPTSSSFTRSHP---PLHEFAD 409
Query 409 LEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCY 468
L + D + + + L+ LN+ + T K + IDT LLK Y
Sbjct 410 LNQLTQGDQDKVAKCKRFLMSYLNE----------VRSTEVANGYK---EDIDTALLKLY 456
Query 469 LHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV----- 523
+ + LL EN C + +S L+K KY L +LY A+Q+ V
Sbjct 457 AEADHDSLLDLLVTEN-FCLLPDSAAWLEKHKKYFALGLLYHYNHQDAAAVQLWVSIVNG 515
Query 524 DQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTED-LPEVES 582
D S L +E V +L + + + L++ ++ WVL+ E G+++FT+ L E +S
Sbjct 516 DIQDSTRSDL--YEYIVDFLTY--STDPDLVWRHADWVLQRSQEVGVQVFTKRPLDEQQS 571
Query 583 -LPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSF 641
D ++ L + + L + YLEH++ +H L LY + E L
Sbjct 572 GFNPDDIISCLKKYPQAL-VKYLEHLVTERRLQKEEYHTHLAVLY-------LDEVLQQR 623
Query 642 PAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGK 701
P TP +++ E+ E + KL L+ S Y L+ GL E A+L G++ +
Sbjct 624 PC--TP----DKDAEVTETQAKLRRLLQESDLYRVHFLMDRTRGAGLPLESAILHGKLEQ 677
Query 702 HEQALFIYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLE 760
HE+AL I VH L D AE+YC + R+ + ++ LL +YL P GP
Sbjct 678 HEEALHILVHELADFPAAEDYCLWRSEGRDPPYRQRLFHLLLAVYLGP------GPAA-- 729
Query 761 LLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQV 820
A AA+ +L H + D + L LLP + +R FL + ++ +R QV
Sbjct 730 ----PARTVAAVDLLNRHAVEFDAAQVLQLLPGTWSVQLLRPFLMGAMRDSIHARRTTQV 785
Query 821 LKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--S 878
L +E L + +++ + +++EK+C +C+ F RYPNG +VH C S
Sbjct 786 AVGLARSENLIYKYDKMKLKGSSVRLSDEKLCQMCQNPFLEPVFVRYPNGGLVHTHCAAS 845
Query 879 KEVNPA 884
+ P+
Sbjct 846 RHTEPS 851
>sp|Q07468|VAM6_YEAST Vacuolar morphogenesis protein 6 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=VAM6 PE=1 SV=1
Length=1049
Score = 131 bits (330), Expect = 6e-30, Method: Compositional matrix adjust.
Identities = 125/463 (27%), Positives = 205/463 (44%), Gaps = 82/463 (18%)
Query 456 LLQIIDTTLLKCYLHTNVALVAPLLRLENNHC--HIEESEHVLKKAHKYSELIILYEKKG 513
+L +IDT L KCYL+ N +V P +R+E NHC H+ +E LK H + +LI Y K+G
Sbjct 599 MLTLIDTVLFKCYLYYNPPMVGPFIRVE-NHCDSHVIVTE--LKIRHMFKDLIDFYYKRG 655
Query 514 LHEKALQV---LVDQSKKANSPLKGHER--------TVQYLQHLGTENLHLIFSYSVWVL 562
HE+AL+ LVD+ + N+ K ++ + YL+ L L +IF+Y+ W+L
Sbjct 656 NHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKILVIYYLKKLSNPQLDVIFTYTDWLL 715
Query 563 RDFPEDGLK-----IFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSR 617
+ D +K IF D S +V G++ + K LAI YLE I + G++
Sbjct 716 -NRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIKKFDKLLAIQYLEFAISTFRLEGNK 774
Query 618 FHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPG 677
H LI+LY E + +P+ R KL LE +S Y+P
Sbjct 775 LHTVLIKLYLENLD----------------IPST---------RIKLKSLLETTSVYEP- 808
Query 678 RLICDFPFDGLLEERALL---------------LGRMGKHEQALFIYVHILKDTRMAEEY 722
R I D + L L ++ H++A+ I + + D + A Y
Sbjct 809 RTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSKLENHKEAVHILLDEIDDYKAATSY 868
Query 723 CHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKL 782
C+ Y + +++ LL +Y SI+ + N + L L+ H SKL
Sbjct 869 CNDVYQSDSTKGEEL---LLYLYSKLVSIY----------DSNRNSKLILNFLQDHGSKL 915
Query 783 DTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQV 842
++ + LP + + DI + ++L+++ K ++ K LL E + +
Sbjct 916 NSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDETRLEKALLQVELVATTYKLNERMSS 975
Query 843 KCIITEEKVCMVCKKKIGN------SAFARYPNGVVVHYFCSK 879
++++ C +CKK I N S F R ++ HY C K
Sbjct 976 YGVLSDSHKCPICKKVISNFGTDSISWFTREGRNIITHYNCGK 1018
>sp|F4I312|VPS3_ARATH Vacuolar sorting protein 3 OS=Arabidopsis
thaliana OX=3702 GN=VPS3 PE=1 SV=2
Length=984
Score = 103 bits (258), Expect = 3e-21, Method: Compositional matrix adjust.
Identities = 193/866 (22%), Positives = 328/866 (38%), Gaps = 146/866 (17%)
Query 116 GASLFTCDLQHTETGEEVLR-----MCVAVKKKLQLYFWKDREFHELQGDFSV------P 164
GA D++ ++ E ++ VA+ +++ L + E L G F V
Sbjct 150 GAGNLVSDVRGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGI 209
Query 165 DVPKSMAWCENSICVGFKRDYYLIR-VDGKGSIKELFP--TGKQLEPLVAPLADGKVAVG 221
K++ W ++ + G + Y LI V G + P +G L L+ + KV +
Sbjct 210 GGIKTLVWLDDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLC--KEWKVLLL 267
Query 222 QDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIEL 281
D++ VV++ G +L + P ++ Y++ V +EI + VQS+
Sbjct 268 VDNVGVVVDTNGQPIGG-SLVFRRRPDSVGELSFYLVTVGDGKMEIHQKKSGACVQSVSF 326
Query 282 Q----RPRFITS---GGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMK 334
P + + G N++ V + + VP QI+ LL+ K++ + L E
Sbjct 327 GPQGCGPSLLAADEAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEEL 386
Query 335 DDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKL-GTDPTHVMGLYPDLLPTDYRK 393
D + + + + L RF+E++ F K +P+ V +P ++ R
Sbjct 387 DSQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEV---FPFIMRDPNRW 443
Query 394 QLQYP-------------------NPLPVLSGAE-LEKAHL-------------ALIDYL 420
L P N L + A L KA + + D L
Sbjct 444 SLVVPRNRYWGLHPPPAPFEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLL 503
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
+ + L S + T P+ EG IDT L+ Y N L
Sbjct 504 DSAIKNITRYLEISREKGLTLPVREG-------------IDTLLMLLYRALNRVEDMENL 550
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPL-KGHERT 539
N+C +EE E +L ++ L LY KG+ KAL + +K +S L + +
Sbjct 551 ASSGNNCVVEELETLLTESGHLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDL 610
Query 540 VQYLQHLGTENL--------------------HLIFSYSVWVLRDFPEDGLKIFTEDLPE 579
V YL L L + W+ P +++ T D
Sbjct 611 VPYLHDNELIRLSGKEAAAAEAARILEEPCDPELALQHLSWIADVNPLFAIQVLTSD-KR 669
Query 580 VESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLI------QLYCEKVQGL 633
E L ++V+ + + Y + +I + T + H L C +VQ
Sbjct 670 TEELSPEQVIQAIDPKKVEIIQRYFQWLIEERDYTDPQLHTSYALSLARSALECVEVQNG 729
Query 634 MKEYLLSFPAGKTPVPAGEE--EGELG-------EYRQKLLMFLEISSYYDPGRLICDFP 684
++E VP G E + +G + R++L FL+ S YDP ++
Sbjct 730 IQE---------ADVPNGSEAHDSNVGSISLFEVDVRERLQAFLQSSDLYDPEEILELVE 780
Query 685 FDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRM 744
L E+A+L R+GK L I L+D AE+YC + G D ++ LL M
Sbjct 781 GSELWLEKAILYRRIGKETLVLQILALKLEDCAAAEQYCVEI------GRPDAFMQLLDM 834
Query 745 YLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFL 804
YL P + EP +AA+++L H LD + L+ L + + +
Sbjct 835 YLDPQNGK----------EPM--FKAAVRLLHNHGESLDPLQVLDKLSPDMPLKLASDTI 882
Query 805 EKVLEENAQKKRFNQVLKNLLHA----EFLRVQEERILHQQVKCIITEEKVCMVCKKKIG 860
++L R Q++ N+ A L EER H Q I +E +C C ++G
Sbjct 883 LRMLRARVHHHRQGQIVHNISRALDVDSRLARLEERSRHMQ----INDESLCDSCYARLG 938
Query 861 NSAFARYPNGVVVHYFCSKEVNPADT 886
FA YP+ +V Y C + + + +
Sbjct 939 TKLFAMYPDDTIVCYKCYRRLGESKS 964
>sp|Q54EH3|Y1510_DICDI GTPase-activating protein DDB_G0291510
OS=Dictyostelium discoideum OX=44689 GN=DDB_G0291510 PE=4 SV=1
Length=1031
Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 48/193 (25%), Positives = 94/193 (49%), Gaps = 10/193 (5%)
Query 87 KILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQL 146
IL + E++I V ++ + T KG D + E E++ + V +KK L L
Sbjct 684 NILTVIGEDSIKVKKIVGTKGCTVYGYTKG------DNEGQE--EDITLLYVGLKKTLLL 735
Query 147 YFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQL 206
Y W EF + + + ++ A ICVG ++++ LI + + +IKEL+
Sbjct 736 YEWNKGEFVKSRELPLMDNIKTLCAIAPGMICVGIQKEFLLIDIFTQ-TIKELYKKSDS- 793
Query 207 EPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVE 266
EP+ A D ++ + +++ + ++E G T++ L W P ++ P Y++ + +E
Sbjct 794 EPVKALSLDNEILLCFNNIGIFVDESGNKTRQFELKWGSTPSSLALVPSYVLGISGPLIE 853
Query 267 IRTFEPRLLVQSI 279
+RT ++QS+
Sbjct 854 VRTLLNGNIIQSL 866
>sp|Q7TT50|MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta
OS=Mus musculus OX=10090 GN=Cdc42bpb PE=1 SV=2
Length=1713
Score = 47.0 bits (110), Expect = 9e-04, Method: Compositional matrix adjust.
Identities = 68/266 (26%), Positives = 107/266 (40%), Gaps = 36/266 (14%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKA----KGASLFTCDLQHTETG 130
KK+ QI + + KI + L N +VH L + + K C L T T
Sbjct 1280 KKVYQIELAPKEKIAILLCGRNHHVH-LYPWSSFDGAEASNFDIKLPETKGCQLIATGTL 1338
Query 131 EEVLRMC--VAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYL 187
+ C VAVK+ + Y + + FH + P + MA ++ +CVG+ + L
Sbjct 1339 RKSSSTCLFVAVKRLILCYEIQRTKPFHRKFSELVAPGHVQWMAVFKDRLCVGYPSGFSL 1398
Query 188 IRVDGKGSIKELF-PTGKQLEPLVAPLADGKVAVGQDD---------LTVVLNEEGICTQ 237
+ + G G +L PT L L D AV + + ++ +G ++
Sbjct 1399 LSIQGDGPPLDLVNPTDPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGRRSR 1458
Query 238 KCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSGGS- 292
L W PVA P + + V Y ++RT E VQ+I L+R R + S GS
Sbjct 1459 MQELMWPAAPVACSCSPTH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSDGSL 1514
Query 293 --------NIIYVASNHFVWRLIPVP 310
+IY N F ++ VP
Sbjct 1515 NLLGCEPPRLIYF-KNKFSGTILNVP 1539
>sp|P53046|ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ROM1
PE=1 SV=2
Length=1155
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 42/154 (27%), Positives = 69/154 (45%), Gaps = 18/154 (12%)
Query 160 DFSVPDVPKSMAWCENSICVGFKRDYYLIRV----DGKG-SIKELFP--TGKQLEPL--- 209
DFSV P S ++ EN IC+G K++ ++ V D G ++EL K L +
Sbjct 987 DFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFKMRELLNLHDNKVLANMYKE 1046
Query 210 ------VAPLADGKVAVGQDDLTVVLNEEGICTQ-KCALNWTDIPVAMEHQPPYIIAVLP 262
+ P+ + A + L LN++G + K +W P PYI+A+
Sbjct 1047 TFKVVSMFPIKNSTFACFPE-LCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINS 1105
Query 263 RYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIY 296
++EIR E LV+ + + R + S I+Y
Sbjct 1106 NFIEIRHIENGELVRCVLGNKIRMLKSYAKKILY 1139
>sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta
OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2
Length=1711
Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 59/241 (24%), Positives = 99/241 (41%), Gaps = 31/241 (13%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGA------SLFTCDLQHTE 128
KK+ QI + + KI++ L N +VH +++ A+G+ C L T
Sbjct 1279 KKVHQIELAPREKIVILLCGRNHHVH----LYPWSSLDGAEGSFDIKLPETKGCQLMATA 1334
Query 129 TGEEVLRMC--VAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDY 185
T + C VAVK+ + Y + + FH + P + +A + +CVG+ +
Sbjct 1335 TLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGF 1394
Query 186 YLIRVDGKGSIKELF-PTGKQLEPLVAPLADGKVAVGQDD---------LTVVLNEEGIC 235
L+ + G G L P L L D AV + + + ++ +G
Sbjct 1395 CLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLCFSHMGLYVDPQGRR 1454
Query 236 TQKCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSGG 291
+ L W PVA P + + V Y ++RT E VQ+I L+R R + S G
Sbjct 1455 ARAQELMWPAAPVACSCSPTH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSEG 1510
Query 292 S 292
+
Sbjct 1511 T 1511
>sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase
OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1
Length=1360
Score = 43.1 bits (100), Expect = 0.013, Method: Compositional matrix adjust.
Identities = 62/281 (22%), Positives = 114/281 (41%), Gaps = 47/281 (17%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + N+ ++
Sbjct 1049 EILCAALWGVNLLVGTENGLMLLDR--------------SGQGKVYNLI----NR---RR 1087
Query 77 IQQIHVVSQFKILVSLL--ENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQ 125
QQ+ V+ +LV++ +N + V+ L V K +G L C
Sbjct 1088 FQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHY 1147
Query 126 HTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------I 177
E + + +A+K +++Y W + +H+ S D+ + + +
Sbjct 1148 KVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKV 1207
Query 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNE 231
G +++I VD S P+ Q + P ++ P DG ++ V +D V +N
Sbjct 1208 IFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNT 1267
Query 232 EGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 271
G T+ L W ++P ++ + I+ + +EIR+ E
Sbjct 1268 YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1308
>sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase
OS=Mus musculus OX=10090 GN=Tnik PE=1 SV=2
Length=1323
Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust.
Identities = 62/281 (22%), Positives = 114/281 (41%), Gaps = 47/281 (17%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + N+ ++
Sbjct 1012 EILCAALWGVNLLVGTENGLMLLDR--------------SGQGKVYNLI----NR---RR 1050
Query 77 IQQIHVVSQFKILVSLL--ENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQ 125
QQ+ V+ +LV++ +N + V+ L V K +G L C
Sbjct 1051 FQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHY 1110
Query 126 HTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------I 177
E + + +A+K +++Y W + +H+ S D+ + + +
Sbjct 1111 KVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKV 1170
Query 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNE 231
G +++I VD S P+ Q + P ++ P DG ++ V +D V +N
Sbjct 1171 IFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNT 1230
Query 232 EGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 271
G T+ L W ++P ++ + I+ + +EIR+ E
Sbjct 1231 YGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1271
>sp|Q7TT49|MRCKB_RAT Serine/threonine-protein kinase MRCK beta
OS=Rattus norvegicus OX=10116 GN=Cdc42bpb PE=1 SV=1
Length=1713
Score = 42.4 bits (98), Expect = 0.027, Method: Compositional matrix adjust.
Identities = 65/269 (24%), Positives = 108/269 (40%), Gaps = 42/269 (16%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASL-------FTCDLQHT 127
KK+ QI + + K+++ L N +VH T+ A+ ++ C L T
Sbjct 1280 KKVYQIELAPKEKLILLLCGRNHHVH----LYPWTSFDGAEASNFDIKLPETKGCQLIAT 1335
Query 128 ETGEEVLRMC--VAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRD 184
T + C VAVK+ + Y + + FH + P + MA ++ +CVG+
Sbjct 1336 GTLRKSSSTCLFVAVKRLVLCYEIQRTKPFHRKFNEIVAPGHVQWMAMFKDRLCVGYPSG 1395
Query 185 YYLIRVDGKGSIKELF-PTGKQLEPLVAPLADGKVAVGQDD---------LTVVLNEEGI 234
+ L+ + G G +L P L L D AV + + ++ +G
Sbjct 1396 FSLLSIQGDGQPLDLVNPADPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGR 1455
Query 235 CTQKCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSG 290
++ L W PVA + + V Y ++RT E VQ+I L+R R + S
Sbjct 1456 RSRTQELMWPAAPVACSCSSSH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSD 1511
Query 291 GS---------NIIYVASNHFVWRLIPVP 310
GS +IY N F ++ VP
Sbjct 1512 GSLNLLGCEPPRLIYF-KNKFSGTVLNVP 1539
>sp|Q9Y7U6|RGF1_SCHPO Rho1 guanine nucleotide exchange factor
1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=rgf1 PE=1 SV=1
Length=1334
Score = 41.2 bits (95), Expect = 0.049, Method: Compositional matrix adjust.
Identities = 36/152 (24%), Positives = 62/152 (41%), Gaps = 17/152 (11%)
Query 163 VPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPL-----VAPLADGK 217
+P S+ + +N +CVG R + ++ +D + L P LE + V P+A +
Sbjct 1151 IPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQSLLDPADTSLEFVEKKENVKPIAIYR 1210
Query 218 VAVGQ-----DDLTVVLNEEGICTQKC-ALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFE 271
+ G+ +N +G ++ + W P PYI+A P ++EIR E
Sbjct 1211 MNGGEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVE 1270
Query 272 PRLLVQSIELQRPRFITSG------GSNIIYV 297
L+ I + R + G G I Y
Sbjct 1271 TSELIHVISGRNIRLLADGRGKLGDGGEIFYA 1302
>sp|Q9UTR5|RGF2_SCHPO Rho1 guanine nucleotide exchange factor
2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=rgf2 PE=1 SV=1
Length=1158
Score = 41.2 bits (95), Expect = 0.050, Method: Compositional matrix adjust.
Identities = 60/275 (22%), Positives = 105/275 (38%), Gaps = 47/275 (17%)
Query 77 IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRM 136
I Q+ V+ + +L+ L E +Y L + ++ +K T + +TG + R+
Sbjct 872 ISQLDVIEEHNVLLLLAEKILYELPLDALDSVEQIN-SKSLRRVTGHVSFVKTGFCMQRI 930
Query 137 CVAVKKK------LQLY----FWKDREFHELQGDFS------------VPDVPKSMAWCE 174
V K L++Y K+++ L+ F +P S+ + +
Sbjct 931 LVCAVKSTVLNTTLRIYEADRALKNKKTQSLKKPFGNQATLKIFTEVQMPMEALSVHFLK 990
Query 175 NSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPL-----VAPLA----DGKVAVGQDDL 225
+CVG + + +I ++ L P L + P+A G+ + D
Sbjct 991 TKLCVGSFKGFDIISLENAVFQSLLNPADTSFRFLEKREDIRPIAMFRLRGEFLLCYSDF 1050
Query 226 TVVLNEEGI-CTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRP 284
+N G Q +NW P PYI+A P ++EIR E LVQ I Q
Sbjct 1051 AFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFIEIRNAETAELVQIIMGQNI 1110
Query 285 RFITSG------GSNIIYVASNHFVWRLIPVPMAT 313
+ +T G G I+Y P+P ++
Sbjct 1111 KLLTDGRGLISEGGEILYSTE--------PIPFSS 1137
>sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase
kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2
Length=1239
Score = 40.0 bits (92), Expect = 0.12, Method: Compositional matrix adjust.
Identities = 66/291 (23%), Positives = 120/291 (41%), Gaps = 67/291 (23%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + N+ ++
Sbjct 928 EILCAALWGVNLLVGTESGLMLLDR--------------SGQGKVYPLI----NR---RR 966
Query 77 IQQIHVVSQFKILV--------------SLLENNIYVHD--LLTFQQITTVSKAKGASLF 120
QQ+ V+ +LV S L N I +D + Q TTV +G
Sbjct 967 FQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG---- 1022
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSI--- 177
C E + + +A+K +++Y W + +H+ S ++ + ++
Sbjct 1023 -CVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEG 1081
Query 178 ---------CVGFKRDYYLIRVDGKGSIKELF-PTGKQ--LEP---LVAPLADG-KVAVG 221
C GF + + VD GS+ +++ PT Q ++P ++ P DG ++ V
Sbjct 1082 QRLKVIYGSCAGF----HAVDVDS-GSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVC 1136
Query 222 QDDLTVVLNEEGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 271
+D V +N G T+ L W ++P ++ + + + + +EIR+ E
Sbjct 1137 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE 1187
>sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus
OX=10090 GN=Mink1 PE=1 SV=3
Length=1308
Score = 40.0 bits (92), Expect = 0.12, Method: Compositional matrix adjust.
Identities = 61/286 (21%), Positives = 109/286 (38%), Gaps = 57/286 (20%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + ++
Sbjct 997 EILCAALWGVNLLVGTENGLMLLDR--------------SGQGKVYGLI-------GRRR 1035
Query 77 IQQIHVVSQFKILV--------------SLLENNIYVHD--LLTFQQITTVSKAKGASLF 120
QQ+ V+ +L+ S L N I +D + Q TTV +G
Sbjct 1036 FQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEG---- 1091
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS---- 176
C E + + +A+K +++Y W + +H+ S D+P + +
Sbjct 1092 -CGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1150
Query 177 ----ICVGFKRDYYLIRVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLT 226
+ G ++ + VD S P Q+ P + P DG ++ + +D
Sbjct 1151 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEG 1210
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFE 271
V +N G + L W ++P ++ + I+ + +EIR+ E
Sbjct 1211 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1256
>sp|F1LP90|MINK1_RAT Misshapen-like kinase 1 OS=Rattus norvegicus
OX=10116 GN=Mink1 PE=1 SV=2
Length=1336
Score = 39.7 bits (91), Expect = 0.16, Method: Compositional matrix adjust.
Identities = 61/286 (21%), Positives = 109/286 (38%), Gaps = 57/286 (20%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + ++
Sbjct 1025 EILCAALWGVNLLVGTENGLMLLDR--------------SGQGKVYGLI-------GRRR 1063
Query 77 IQQIHVVSQFKILV--------------SLLENNIYVHD--LLTFQQITTVSKAKGASLF 120
QQ+ V+ +L+ S L N I +D + Q TTV +G
Sbjct 1064 FQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEG---- 1119
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS---- 176
C E + + +A+K +++Y W + +H+ S D+P + +
Sbjct 1120 -CGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1178
Query 177 ----ICVGFKRDYYLIRVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLT 226
+ G ++ + VD S P Q+ P + P DG ++ + +D
Sbjct 1179 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEG 1238
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFE 271
V +N G + L W ++P ++ + I+ + +EIR+ E
Sbjct 1239 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1284
>sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens
OX=9606 GN=MINK1 PE=1 SV=2
Length=1332
Score = 39.7 bits (91), Expect = 0.18, Method: Compositional matrix adjust.
Identities = 61/286 (21%), Positives = 109/286 (38%), Gaps = 57/286 (20%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + ++
Sbjct 1021 EILCAALWGVNLLVGTENGLMLLDR--------------SGQGKVYGLI-------GRRR 1059
Query 77 IQQIHVVSQFKILV--------------SLLENNIYVHD--LLTFQQITTVSKAKGASLF 120
QQ+ V+ +L+ S L N I +D + Q TTV +G
Sbjct 1060 FQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEG---- 1115
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS---- 176
C E + + +A+K +++Y W + +H+ S D+P + +
Sbjct 1116 -CGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1174
Query 177 ----ICVGFKRDYYLIRVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLT 226
+ G ++ + VD S P Q+ P + P DG ++ + +D
Sbjct 1175 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEG 1234
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFE 271
V +N G + L W ++P ++ + I+ + +EIR+ E
Sbjct 1235 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVE 1280
>sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase
kinase kinase 4 OS=Mus musculus OX=10090 GN=Map4k4 PE=1 SV=1
Length=1233
Score = 39.3 bits (90), Expect = 0.18, Method: Compositional matrix adjust.
Identities = 65/291 (22%), Positives = 118/291 (41%), Gaps = 67/291 (23%)
Query 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKK 76
+I C A W LLVGT+ G +LL R SG + + ++
Sbjct 922 EILCAALWGVNLLVGTESGLMLLDR--------------SGQGKVYPLISR-------RR 960
Query 77 IQQIHVVSQFKILV--------------SLLENNIYVHD--LLTFQQITTVSKAKGASLF 120
QQ+ V+ +LV S L N I +D + Q TTV +G
Sbjct 961 FQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG---- 1016
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSI--- 177
C E + + +A+K +++Y W + +H+ S ++ + ++
Sbjct 1017 -CVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELLHKPLLVDLTVEEG 1075
Query 178 ---------CVGFKRDYYLIRVDGKGSIKELF-PTGKQ--LEP---LVAPLADG-KVAVG 221
C GF + + VD GS+ +++ PT Q ++P ++ P DG ++ V
Sbjct 1076 QRLKVIYGSCAGF----HAVDVD-SGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVC 1130
Query 222 QDDLTVVLNEEGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 271
+D V +N G T+ L W ++P ++ + + + + +EIR+ E
Sbjct 1131 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE 1181
>sp|P93043|VPS41_ARATH Vacuolar protein sorting-associated protein
41 homolog OS=Arabidopsis thaliana OX=3702 GN=VPS41 PE=1
SV=3
Length=980
Score = 38.5 bits (88), Expect = 0.35, Method: Compositional matrix adjust.
Identities = 45/176 (26%), Positives = 75/176 (43%), Gaps = 40/176 (23%)
Query 658 GEYRQKLLM-FLEISSYY--DPGRLIC---DFPFDGLLEERALLLGRMGKHEQALFIYVH 711
EY K+L+ FL S +Y + +C DF L E+ +LGRMG +QAL + ++
Sbjct 678 AEYDTKMLLPFLRSSQHYKLEKAYELCVKKDF-----LREQVFVLGRMGNAKQALAVIIN 732
Query 712 ILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAA 771
L D A E+ +D D++ L++ L+ P + L
Sbjct 733 KLGDIEEAVEFVSMQHD------DDLWEELIKQCLNKPEMVGL----------------- 769
Query 772 LQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVL----EENAQKKRFNQVLKN 823
+LE LD +N++P +I +R L K++ E + + N +LK
Sbjct 770 --LLEHTVGNLDPLYIVNMVPNGLEIPRLRDRLVKIVTDYRTETSLRHGCNDILKT 823
>sp|Q5VT25|MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha
OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1
Length=1732
Score = 38.1 bits (87), Expect = 0.44, Method: Compositional matrix adjust.
Identities = 36/168 (21%), Positives = 73/168 (43%), Gaps = 11/168 (7%)
Query 136 MCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKG 194
+CVA+K+++ Y ++ + H + VP + MA +CVGF+ + ++G+G
Sbjct 1330 LCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEG 1389
Query 195 SIKELFPTGKQLEPLVA--PL-ADGKVAVGQDDLTVVLNEEGICT-------QKCALNWT 244
+ + + +A P+ A V + + + N GI T ++ L W
Sbjct 1390 NPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWP 1449
Query 245 DIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 292
P + + PY+ V+I +Q++ L++ R + + GS
Sbjct 1450 ANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGS 1497
>sp|P51862|ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ROM2
PE=1 SV=1
Length=1356
Score = 37.0 bits (84), Expect = 1.1, Method: Compositional matrix adjust.
Identities = 28/139 (20%), Positives = 61/139 (44%), Gaps = 9/139 (6%)
Query 167 PKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLE----PLVAPLADGKVA--- 219
P S+++ + ++C+G K+ + ++ + L P LE + P+A +V
Sbjct 1200 PVSISFLKANLCIGCKKGFQIVSISQNAHESLLDPADTSLEFALRDTLKPMAIYRVGNMF 1259
Query 220 -VGQDDLTVVLNEEGICTQKC-ALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQ 277
+ + +N +G ++ ++W P PYI+A ++EIR E L++
Sbjct 1260 LLCYTEFAFFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIETGELIR 1319
Query 278 SIELQRPRFITSGGSNIIY 296
+ + R + + I+Y
Sbjct 1320 CVLADKIRLLQTSTQEILY 1338
>sp|A5PF44|GARL3_DANRE GTPase-activating Rap/Ran-GAP domain-like
protein 3 OS=Danio rerio OX=7955 GN=garnl3 PE=3 SV=1
Length=1015
Score = 36.6 bits (83), Expect = 1.4, Method: Compositional matrix adjust.
Identities = 81/366 (22%), Positives = 128/366 (35%), Gaps = 104/366 (28%)
Query 3 DAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRF 62
+ +E P I C +W + LLV T ++L + P V F
Sbjct 486 EPWESQSFCSSFPYDIVCGDSWGQSLLVATDSAGVMLLEDSPTLPPVQV----------F 535
Query 63 EVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENN----IYVHDLLTFQQI---------- 108
+ TL ++Q+HV+ +L++ + +YV+ L T +Q
Sbjct 536 DKTL---------TVKQMHVLEPQDLLIARADKGKDARLYVYRLSTLKQGIEERQLVRTK 586
Query 109 -----TTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWK------------- 150
+ K KG L++ + H G E LR+ A++ KL L K
Sbjct 587 CDSRENKLEKTKGCHLYSINTHH---GVE-LRIVAAIRNKLLLITRKQSRLECVSSIATV 642
Query 151 ----DREFHELQ--GDFSVPDVPKSMAWCENS-------ICVGFKRDYYLIRVDGKGSIK 197
D E Q + + D P MA + ICV ++ + LI + G
Sbjct 643 TGSTDSPVEEFQYIREICLCDSPVVMALVDGPTGENDHMICVAYRHQFDLIN-ESTGDAY 701
Query 198 ELFPTGKQLEPLVAPL---ADGKVAVGQDDLTVVLNEEGICTQK--CALN---------- 242
L VA + DG+ ++L IC K C N
Sbjct 702 RLHHVDSNRVNFVAAIDVYEDGEAG-------LLLCYNNICVYKKVCPFNGATPMIQPNT 754
Query 243 ------WTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSI---ELQRPRFITSGGSN 293
W +P A PYI+A +EIR LV + ELQ +T+ S+
Sbjct 755 SDFHFSWNQMPNATVCAFPYILAFTTDSIEIRLVVNGNLVYTAVVPELQ----LTASRSD 810
Query 294 IIYVAS 299
I +++S
Sbjct 811 IYFISS 816
>sp|Q8IVF5|TIAM2_HUMAN Rho guanine nucleotide exchange factor
TIAM2 OS=Homo sapiens OX=9606 GN=TIAM2 PE=2 SV=4
Length=1701
Score = 36.6 bits (83), Expect = 1.5, Method: Compositional matrix adjust.
Identities = 30/109 (28%), Positives = 49/109 (45%), Gaps = 21/109 (19%)
Query 604 LEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVP-----AGEEEGELG 658
+E+ I WE+ +FH L ++ C YL S G+ P P A +L
Sbjct 673 IENQIQQWEQNLEKFHMDLFRMRC---------YLASLQGGELPNPKSLLAAASRPSKLA 723
Query 659 EYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALF 707
R L L +SS++ L+C D L +R L L + G++++ +F
Sbjct 724 LGR---LGILSVSSFH---ALVCSRD-DSALRKRTLSLTQRGRNKKGIF 765
>sp|Q3UU96|MRCKA_MOUSE Serine/threonine-protein kinase MRCK alpha
OS=Mus musculus OX=10090 GN=Cdc42bpa PE=1 SV=2
Length=1719
Score = 36.2 bits (82), Expect = 1.8, Method: Compositional matrix adjust.
Identities = 36/171 (21%), Positives = 72/171 (42%), Gaps = 17/171 (10%)
Query 136 MCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKG 194
+CVA+K+++ Y ++ + H + VP + MA +CVGF+ + ++G+G
Sbjct 1317 LCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEG 1376
Query 195 SIKELFPTGKQL------EPLVAPLADGKVAVGQDDLTVVLNEEGICT-------QKCAL 241
+ + +P+ A A V + + + N GI T ++ L
Sbjct 1377 GPCNMLHSNDHTLSFISHQPMDALCA---VEISNKEYLLCFNSIGIYTDCQGRRSRQQEL 1433
Query 242 NWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 292
W P + + PY+ V+I +Q++ L++ R + + GS
Sbjct 1434 MWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGS 1484
>sp|O54874|MRCKA_RAT Serine/threonine-protein kinase MRCK alpha
OS=Rattus norvegicus OX=10116 GN=Cdc42bpa PE=1 SV=1
Length=1732
Score = 35.8 bits (81), Expect = 2.6, Method: Compositional matrix adjust.
Identities = 33/168 (20%), Positives = 77/168 (46%), Gaps = 11/168 (7%)
Query 136 MCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKG 194
+CVA+K+++ Y ++ + H + VP + MA +CVGF+ + ++G+G
Sbjct 1330 LCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEG 1389
Query 195 SIKEL---------FPTGKQLEPLVA-PLADGKVAVGQDDLTVVLNEEGICTQKCALNWT 244
S + F T + ++ + A +++ + + + + + +G +++ L W
Sbjct 1390 SPCNMLHSNDHTLAFITHQPMDAICAVEISNKEYLLCFSSIGIYTDCQGRRSRQQELMWP 1449
Query 245 DIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 292
P + + PY+ V+I +Q++ L++ R + + GS
Sbjct 1450 ANPSSCCYNAPYLSIYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGS 1497
>sp|Q6ZPF3|TIAM2_MOUSE Rho guanine nucleotide exchange factor
TIAM2 OS=Mus musculus OX=10090 GN=Tiam2 PE=1 SV=2
Length=1715
Score = 35.8 bits (81), Expect = 2.7, Method: Compositional matrix adjust.
Identities = 31/109 (28%), Positives = 48/109 (44%), Gaps = 21/109 (19%)
Query 604 LEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVP-----AGEEEGELG 658
+E+ I WE+ +FH L ++ C YL S G+ P P A +L
Sbjct 671 IENQIRQWEQNLEKFHMDLFRMRC---------YLASLQGGELPNPKSLLAATSRPSKLA 721
Query 659 EYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALF 707
R L L +SS++ L+C D L +R L L + GK ++ +F
Sbjct 722 LGR---LGVLSVSSFH---ALVCSRD-DSTLRKRTLSLTQRGKSKKGIF 763
>sp|Q502L7|KAD8_DANRE Adenylate kinase 8 OS=Danio rerio OX=7955
GN=ak8 PE=2 SV=1
Length=486
Score = 35.0 bits (79), Expect = 3.2, Method: Compositional matrix adjust.
Identities = 47/181 (26%), Positives = 82/181 (45%), Gaps = 30/181 (17%)
Query 662 QKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFI-YVHILKD----T 716
Q L+ FLE + P ++ P G + + ++ +H QA+ I + ILKD T
Sbjct 44 QYLINFLERDNVDVPRIILLGPPASG----KKTVAKKLCEHTQAIHITFCDILKDDSDLT 99
Query 717 RMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLE 776
R A+ Y YD+ ++ KD+++ L++ LS P G + LE + PK +A L
Sbjct 100 RAAQSY----YDKKQNVPKDLWIQLIQQRLSKPDCVQRGWV-LEAI-PKTQDEA----LC 149
Query 777 LHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEER 836
L + + + L + D+ VL E + KR + V ++ H F+ + E
Sbjct 150 LQEAGITPDHVVML-----EAPDV------VLIERSSGKRIDPVTGDVYHVTFMWPESEE 198
Query 837 I 837
+
Sbjct 199 V 199
>sp|P93231|VPS41_SOLLC Vacuolar protein sorting-associated protein
41 homolog OS=Solanum lycopersicum OX=4081 GN=VPS41 PE=2
SV=1
Length=960
Score = 33.9 bits (76), Expect = 9.5, Method: Compositional matrix adjust.
Identities = 39/167 (23%), Positives = 69/167 (41%), Gaps = 29/167 (17%)
Query 664 LLMFLEISSYY--DPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEE 721
LL FL S +Y + IC LL+E+ +LGRMG +QAL + ++ L D A E
Sbjct 670 LLTFLRSSQHYTLEKAYEIC--VKKDLLKEQVFILGRMGNAKQALAVIINRLGDIEEAIE 727
Query 722 YCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSK 781
+ D +++ L++ P + + +LE
Sbjct 728 FVSMQQD------DELWEELIQQSFHKPEMVGV-------------------LLEHTVGN 762
Query 782 LDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAE 828
LD +N+LP + +I +R L K++ + + ++L A+
Sbjct 763 LDPLYIVNMLPNDLEIPRLRDRLVKIVTDYRTETSLRHGCNDILKAD 809
Lambda K H a alpha
0.321 0.138 0.410 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 101801316738
Results from round 2
Query= sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens
OX=9606 GN=VPS39 PE=1 SV=2
Length=886
Score E
Sequences producing significant alignments: (Bits) Value
Sequences used in model and found again:
sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens OX=... 1131 0.0
sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein OS=Mus musculus OX=... 1122 0.0
sp|Q8WUH2|TGFA1_HUMAN Transforming growth factor-beta receptor-as... 899 0.0
sp|Q3UR70|TGFA1_MOUSE Transforming growth factor-beta receptor-as... 891 0.0
sp|A7MB11|TGFA1_BOVIN Transforming growth factor-beta receptor-as... 886 0.0
sp|Q1ZXS5|VPS39_CAEEL Vacuolar protein sorting-associated protein... 798 0.0
sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-as... 791 0.0
sp|Q8L5Y0|VPS39_ARATH Vacuolar sorting protein 39 OS=Arabidopsis ... 729 0.0
sp|O13955|VAM6_SCHPO Vacuolar morphogenesis protein 6 OS=Schizosa... 665 0.0
sp|F4I312|VPS3_ARATH Vacuolar sorting protein 3 OS=Arabidopsis th... 598 0.0
sp|Q07468|VAM6_YEAST Vacuolar morphogenesis protein 6 OS=Saccharo... 349 9e-104
sp|Q7TT50|MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta O... 187 2e-47
sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta O... 186 5e-47
sp|Q54EH3|Y1510_DICDI GTPase-activating protein DDB_G0291510 OS=D... 171 2e-42
sp|P53046|ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS=Saccharom... 119 3e-26
Sequences not found previously or not previously below threshold:
sp|Q7TT49|MRCKB_RAT Serine/threonine-protein kinase MRCK beta OS=... 184 3e-46
sp|Q3UU96|MRCKA_MOUSE Serine/threonine-protein kinase MRCK alpha ... 129 4e-29
sp|Q5VT25|MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha ... 128 1e-28
sp|O54874|MRCKA_RAT Serine/threonine-protein kinase MRCK alpha OS... 128 1e-28
sp|O59796|VPS3_SCHPO Vacuolar protein sorting-associated protein ... 123 2e-27
sp|Q6DT37|MRCKG_HUMAN Serine/threonine-protein kinase MRCK gamma ... 101 3e-20
sp|P51862|ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS=Saccharom... 96.5 7e-19
sp|Q80UW5|MRCKG_MOUSE Serine/threonine-protein kinase MRCK gamma ... 94.2 3e-18
sp|Q9Y7U6|RGF1_SCHPO Rho1 guanine nucleotide exchange factor 1 OS... 90.3 5e-17
sp|E7F590|VPS41_DANRE Vacuolar protein sorting-associated protein... 89.5 6e-17
sp|P23643|VPS3_YEAST Vacuolar protein sorting-associated protein ... 88.4 2e-16
sp|Q9UTR5|RGF2_SCHPO Rho1 guanine nucleotide exchange factor 2 OS... 87.6 3e-16
sp|Q5KU39|VPS41_MOUSE Vacuolar protein sorting-associated protein... 86.8 5e-16
sp|P49754|VPS41_HUMAN Vacuolar protein sorting-associated protein... 85.3 1e-15
sp|Q19954|VPS41_CAEEL Vacuolar protein sorting-associated protein... 76.0 9e-13
sp|O01583|MRCK_CAEEL Serine/threonine-protein kinase mrck-1 OS=Ca... 75.3 2e-12
sp|P93231|VPS41_SOLLC Vacuolar protein sorting-associated protein... 73.7 5e-12
sp|A5PF44|GARL3_DANRE GTPase-activating Rap/Ran-GAP domain-like p... 71.4 3e-11
sp|Q9W1B0|GEK_DROME Serine/threonine-protein kinase Genghis Khan ... 69.5 1e-10
sp|P59015|VPS18_DANRE Vacuolar protein sorting-associated protein... 68.3 3e-10
sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus OX=... 68.0 3e-10
sp|F1LP90|MINK1_RAT Misshapen-like kinase 1 OS=Rattus norvegicus ... 68.0 4e-10
sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens OX=... 68.0 4e-10
sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS=... 66.4 1e-09
sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS=... 66.0 1e-09
sp|Q24314|VPS18_DROME Vacuolar protein sorting-associated protein... 65.3 2e-09
sp|Q5ZJY3|GARL3_CHICK GTPase-activating Rap/Ran-GAP domain-like p... 64.1 5e-09
sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase kina... 64.1 5e-09
sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kina... 63.7 7e-09
sp|Q5VVW2|GARL3_HUMAN GTPase-activating Rap/Ran-GAP domain-like p... 63.0 1e-08
sp|Q23356|MIG15_CAEEL Serine/threonine-protein kinase mig-15 OS=C... 63.0 1e-08
sp|F4IDS7|VPS18_ARATH Vacuolar sorting protein 18 OS=Arabidopsis ... 61.4 3e-08
sp|Q3V0G7|GARL3_MOUSE GTPase-activating Rap/Ran-GAP domain-like p... 59.9 9e-08
sp|P49025|CTRO_MOUSE Citron Rho-interacting kinase OS=Mus musculu... 59.9 1e-07
sp|E9PSL7|CTRO_RAT Citron rho-interacting kinase OS=Rattus norveg... 59.5 2e-07
sp|O14578|CTRO_HUMAN Citron Rho-interacting kinase OS=Homo sapien... 57.6 5e-07
sp|Q618H8|VPS41_CAEBR Vacuolar protein sorting-associated protein... 57.2 6e-07
sp|Q9P253|VPS18_HUMAN Vacuolar protein sorting-associated protein... 56.0 1e-06
sp|P27801|PEP3_YEAST Vacuolar membrane protein PEP3 OS=Saccharomy... 54.5 4e-06
sp|Q8R307|VPS18_MOUSE Vacuolar protein sorting-associated protein... 54.5 4e-06
sp|Q9P7N3|VPS41_SCHPO Vacuolar protein sorting-associated protein... 53.3 9e-06
sp|Q9Y7U5|RGF3_SCHPO Rho1 guanine nucleotide exchange factor 3 OS... 53.7 9e-06
sp|P38959|VPS41_YEAST Vacuolar protein sorting-associated protein... 52.6 2e-05
sp|P93043|VPS41_ARATH Vacuolar protein sorting-associated protein... 51.8 3e-05
sp|P12868|PEP5_YEAST E3 ubiquitin-protein ligase PEP5 OS=Saccharo... 50.2 8e-05
sp|Q10161|CLH_SCHPO Probable clathrin heavy chain OS=Schizosaccha... 44.5 0.005
sp|Q09600|VPS11_CAEEL Vacuolar protein sorting-associated protein... 44.1 0.008
sp|Q9P6N4|PEP5_SCHPO E3 ubiquitin-protein ligase pep5 OS=Schizosa... 41.0 0.057
sp|P19721|SPIKE_ADEM1 Fiber protein OS=Murine adenovirus A seroty... 40.2 0.086
sp|P39702|VPS8_YEAST Vacuolar protein sorting-associated protein ... 39.1 0.25
sp|Q9VF81|TMTC4_DROME Protein O-mannosyl-transferase Tmtc4 OS=Dro... 38.3 0.35
sp|Q9LFQ3|SNL2_ARATH Paired amphipathic helix protein Sin3-like 2... 37.9 0.54
sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 OS=Homo sapiens OX=96... 37.5 0.77
sp|Q29NU5|GLT25_DROPS Glycosyltransferase 25 family member OS=Dro... 37.1 0.90
sp|Q6MMQ9|MIAA_BDEBA tRNA dimethylallyltransferase OS=Bdellovibri... 36.4 1.0
sp|A8XBZ8|BAR1_CAEBR Beta-catenin/armadillo-related protein 1 OS=... 36.8 1.0
sp|P22137|CLH_YEAST Clathrin heavy chain OS=Saccharomyces cerevis... 36.8 1.4
sp|Q5UNZ2|YR739_MIMIV Putative BTB/POZ domain and WD-repeat prote... 36.4 1.4
sp|C0PEY7|PYG7_MAIZE Tetratricopeptide repeat domain-containing p... 35.2 2.6
sp|Q502L7|KAD8_DANRE Adenylate kinase 8 OS=Danio rerio OX=7955 GN... 35.2 2.6
sp|Q59LR2|ATR_CANAL Serine/threonine-protein kinase MEC1 OS=Candi... 35.6 3.0
sp|Q5BJE1|CC178_HUMAN Coiled-coil domain-containing protein 178 O... 34.4 6.5
sp|O95163|ELP1_HUMAN Elongator complex protein 1 OS=Homo sapiens ... 34.1 8.3
sp|Q9VRX2|VPS8_DROME Vacuolar protein sorting-associated protein ... 33.7 9.8
sp|Q88YN5|PHNC_LACPL Phosphonates import ATP-binding protein PhnC... 32.9 10.0
>sp|Q96JC1|VPS39_HUMAN Vam6/Vps39-like protein OS=Homo sapiens
OX=9606 GN=VPS39 PE=1 SV=2
Length=886
Score = 1131 bits (2925), Expect = 0.0, Method: Composition-based stats.
Identities = 886/886 (100%), Positives = 886/886 (100%), Gaps = 0/886 (0%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
Sbjct 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
Query 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
Sbjct 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
Sbjct 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
Query 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
Sbjct 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
Query 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
Sbjct 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
Query 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
Sbjct 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
Query 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
Sbjct 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
Sbjct 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
Sbjct 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
Query 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
Sbjct 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
Query 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
Sbjct 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
Query 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
Sbjct 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
Query 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
Sbjct 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
Query 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
Sbjct 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
Query 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
Sbjct 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
>sp|Q8R5L3|VPS39_MOUSE Vam6/Vps39-like protein OS=Mus musculus
OX=10090 GN=Vps39 PE=1 SV=1
Length=886
Score = 1122 bits (2901), Expect = 0.0, Method: Composition-based stats.
Identities = 863/886 (97%), Positives = 877/886 (99%), Gaps = 0/886 (0%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
Sbjct 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
Query 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
Sbjct 61 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF 120
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
TCDLQHTETGEEVLRMCVAV+KKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
Sbjct 121 TCDLQHTETGEEVLRMCVAVRKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG 180
Query 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
Sbjct 181 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA 240
Query 241 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
LNWTDIPVAMEHQPPYI+AVLPRYVEIRT EPRLLVQSIELQRPRFITSGGSNIIYVASN
Sbjct 241 LNWTDIPVAMEHQPPYIVAVLPRYVEIRTLEPRLLVQSIELQRPRFITSGGSNIIYVASN 300
Query 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
Sbjct 301 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK 360
Query 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL 420
RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLP LSGAELEKAHLALIDYL
Sbjct 361 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPTLSGAELEKAHLALIDYL 420
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
Sbjct 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
Sbjct 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV 540
Query 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA 600
QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVL FLIENFK LA
Sbjct 541 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLNFLIENFKALA 600
Query 601 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY 660
IPYLEHIIHVWEETGS+FHNCLIQLYCEKVQ LMK+YLLS P GK+PVPAGEE GELGEY
Sbjct 601 IPYLEHIIHVWEETGSQFHNCLIQLYCEKVQSLMKDYLLSLPTGKSPVPAGEEGGELGEY 660
Query 661 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
RQKLLMFLEISS+YDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVH+LKDT+MA+
Sbjct 661 RQKLLMFLEISSHYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTKMAK 720
Query 721 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS 780
EYCHKHYD+NK+GNKDVYLSLLRMYLSPPSIHCLGPIKLELLEP+ANLQAALQVLELH+S
Sbjct 721 EYCHKHYDQNKEGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPQANLQAALQVLELHYS 780
Query 781 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
KLDTTKA+NLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
Sbjct 781 KLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ 840
Query 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 886
QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVN ADT
Sbjct 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNSADT 886
>sp|Q8WUH2|TGFA1_HUMAN Transforming growth factor-beta receptor-associated
protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1
SV=1
Length=860
Score = 899 bits (2323), Expect = 0.0, Method: Composition-based stats.
Identities = 223/916 (24%), Positives = 398/916 (43%), Gaps = 98/916 (11%)
Query 3 DAFEPVPILEKL-------PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPE 55
AF V +E+ + I+C+ L VGT + + + + VPA A+
Sbjct 5 KAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPAT-- 62
Query 56 SGSCNRFEVTLE-KSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKA 114
F T + + + F K + ++ S L+ L +N+I + ++L + + + ++
Sbjct 63 ------FTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARI 116
Query 115 KGASLFTCDLQHTETGEEVLRMCV-AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWC 173
KGA+ F + + +C+ +VK++ F + ++ + S + P ++A
Sbjct 117 KGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVD 176
Query 174 ENSICVGFKRDYYLIRVDGKGSIKELFP-TGKQLEPLVAPLADGKVAV-GQDDLTVVLNE 231
+ +C+ Y +I G ++LFP ++ P+V + + + G L +
Sbjct 177 GHFLCLALTTQY-IIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATV 235
Query 232 EGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGG 291
GI +Q+ ++W++ + PY+IA+ ++ + + + Q++ + +
Sbjct 236 AGI-SQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFE 294
Query 292 SNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL 351
+I VA++ V+ L+P+P+ QIQ LL ++ E AL LA+ + +++ Q+ + + L
Sbjct 295 GRVI-VATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRIL 353
Query 352 --YAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYP--------NPL 401
F F Q +F E+ ++F D ++ LYP LLPT +P N L
Sbjct 354 QQAGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQL 413
Query 402 PVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIID 461
++ K L+ YL + RS V D ID
Sbjct 414 TQGDQEKMAKCKRFLMSYLNEVRSTEVANGYKED------------------------ID 449
Query 462 TTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQV 521
T LLK Y + + LL E N C + +S L+K KY L +LY A+Q+
Sbjct 450 TALLKLYAEADHDSLLDLLVTE-NFCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQL 508
Query 522 LV-----DQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTE- 575
V D S L +E V +L + E L+++Y+ WVL+ E G+++FT+
Sbjct 509 WVNIVNGDVQDSTRSDL--YEYIVDFLTYCLDEE--LVWAYADWVLQKSEEVGVQVFTKR 564
Query 576 --DLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGL 633
D + S D ++ L + K L + YLEH++ +H L LY E+V
Sbjct 565 PLDEQQKNSFNPDDIINCLKKYPKAL-VKYLEHLVIDKRLQKEEYHTHLAVLYLEEVL-- 621
Query 634 MKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERA 693
A + E E + KL L+ S Y L+ GL E A
Sbjct 622 -----------LQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERLQGAGLPMESA 670
Query 694 LLLGRMGKHEQALFIYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIH 752
+L G++G+HE+AL I VH L+D AE+YC R+ + ++ +LL +YL
Sbjct 671 ILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYLHA---- 726
Query 753 CLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENA 812
GP EL AA+ +L H ++ D + L +LP + + FL + ++
Sbjct 727 --GPTAHELA------VAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSI 778
Query 813 QKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVV 872
+R QV L +E L +++ + ++++K+C +C+ F RYPNG +
Sbjct 779 HARRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGL 838
Query 873 VHYFC--SKEVNPADT 886
VH C S+ NP+ +
Sbjct 839 VHTHCAASRHTNPSSS 854
>sp|Q3UR70|TGFA1_MOUSE Transforming growth factor-beta receptor-associated
protein 1 OS=Mus musculus OX=10090 GN=Tgfbrap1
PE=1 SV=1
Length=860
Score = 891 bits (2303), Expect = 0.0, Method: Composition-based stats.
Identities = 219/914 (24%), Positives = 395/914 (43%), Gaps = 96/914 (11%)
Query 3 DAFEPVPILEKL-------PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPE 55
AF V +E+ + I+C+ L VGT + + + + +P A+
Sbjct 5 KAFTLVSAVERELLMGDRDHISIECVECCGRNLYVGTNDCFIYHFLLEEKAMPTGTAT-- 62
Query 56 SGSCNRFEVTLE-KSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKA 114
F T + + F K + ++ S L+ L +N+I + ++L + + + ++
Sbjct 63 ------FVATKQLHRHLGFKKPVNELCAASALNRLLVLCDNSITLVNMLNLEPVPSGARI 116
Query 115 KGASLFTCDLQHTETGEEVLRMCV-AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWC 173
KGA+ F + + +C+ +VK++ F + ++ + S P+ P ++A
Sbjct 117 KGATTFAVNESPVNGDPFCVEVCIISVKRRTVQMFLVYEDRVQIVKEVSTPEQPLAVAVD 176
Query 174 ENSICVGFKRDYYLIRVDGKGSIKELFP-TGKQLEPLVAPLADGKVAV-GQDDLTVVLNE 231
+C+ Y ++ G ++LFP ++ P+V + + + G L +
Sbjct 177 GYFLCLALTTQYIILNY-STGLSQDLFPYCSEEKPPIVKRIGRQEFLLAGPGGLGMFATV 235
Query 232 EGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGG 291
GI +Q+ ++W++ + PY+IA+ ++ + + + Q++ + +
Sbjct 236 AGI-SQRAPVHWSENVIGAAVCFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFE 294
Query 292 SNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL 351
+I VA++ V+ L+P+P+ QIQ LL +++ E AL LA+ + +++ Q+ + + L
Sbjct 295 GRVI-VATSKGVYILVPLPLEKQIQDLLANRRVEEALVLAKGARRNIPKEKFQVMYRRIL 353
Query 352 --YAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYP--------NPL 401
F F Q +F E+ ++F D ++ LYP LLPT +P N L
Sbjct 354 QQAGFIQFAQLQFLEAKELFRSSQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQL 413
Query 402 PVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIID 461
++ K L+ YL + RS V D ID
Sbjct 414 TQGDQEKMAKCKRFLMSYLNEIRSTEVANGYKED------------------------ID 449
Query 462 TTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQV 521
T LLK Y + + LL E N C + +S L+K KY L +LY A+Q+
Sbjct 450 TALLKLYAEADHDSLLDLLVTE-NFCLLTDSAAWLEKHKKYFALGLLYHYNKQDASAVQL 508
Query 522 LV-----DQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTE- 575
V D S L +E V +L + + L+++++ W+L+ E G++IFT+
Sbjct 509 WVNIVNGDIQDSTRSDL--YEYIVDFLTYCLDQE--LVWTHADWLLQKSEEIGVQIFTKR 564
Query 576 --DLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGL 633
D + S D ++ L + K L + YLEH++ +H L LY E+V
Sbjct 565 PLDEQQQTSFNPDNIISSLKKYPKAL-VKYLEHLVIDRRLQKEEYHTHLAILYLEEVL-- 621
Query 634 MKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERA 693
+ V G ++ E E + KL L+ S Y L GL E A
Sbjct 622 -----------RQRVSTGGKDVEATETQAKLRRLLQKSDLYRVHLLKEKVQGAGLPMESA 670
Query 694 LLLGRMGKHEQALFIYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIH 752
+L G++G+HE+AL I VH + D AE+YC + + ++ +LL MYL
Sbjct 671 ILHGKLGEHEKALHILVHEMGDFSAAEDYCLWSSEGQGAACRQRLFHTLLAMYLRA---- 726
Query 753 CLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENA 812
GP +L AA+ +L H + D T+ L LLP + + FL + ++
Sbjct 727 --GPSAQDL------TVAAVDLLNHHAREFDVTQVLQLLPDTWSVQLLCPFLMGAMRDSI 778
Query 813 QKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVV 872
+R QV L +E L +++ + ++E ++C +C+ G F RYPNG +
Sbjct 779 HARRTTQVALGLAKSENLIYMYDKMKLKGNAVRLSERELCQLCQNPFGEPVFVRYPNGGL 838
Query 873 VHYFCSKEVNPADT 886
VH C+ + A +
Sbjct 839 VHTHCAASRHTAPS 852
>sp|A7MB11|TGFA1_BOVIN Transforming growth factor-beta receptor-associated
protein 1 OS=Bos taurus OX=9913 GN=TGFBRAP1 PE=2
SV=1
Length=859
Score = 886 bits (2289), Expect = 0.0, Method: Composition-based stats.
Identities = 212/906 (23%), Positives = 398/906 (44%), Gaps = 81/906 (9%)
Query 3 DAFEPVPILEKLPLQ-------IDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPE 55
AF VP +E+ L ++C+ L VGT + + + + +P A+
Sbjct 5 KAFTLVPAIEREQLLSDRDRGLLECVECCGRNLYVGTSDCFVYHFLLEEKTLPGGSAT-- 62
Query 56 SGSCNRFEVTLE-KSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKA 114
F T + + F K + ++ S L+ L + I + +L+ + + + ++
Sbjct 63 ------FTATRQLHRHLGFKKAVSELRAASALSRLLVLCDGCISLVHMLSLEPVPSGARI 116
Query 115 KGASLFTCDLQHTETGEEVLRMCV-AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWC 173
KGA+ F + + +C+ +VK++ F + ++ + S P+ P ++A
Sbjct 117 KGATAFALNENPVSGDPFCVEVCIISVKRRTIQVFLVYEDRVQIVREVSTPEQPLAVAVD 176
Query 174 ENSICVGFKRDYYLIRVDGKGSIKELFP-TGKQLEPLVAPLADGKVAV-GQDDLTVVLNE 231
+ +C+ Y ++ G+ ++LFP ++ P+V + + + G L +
Sbjct 177 GHFLCLALTTQYIILNY-STGAAQDLFPFCSEERRPIVKRIGRQEFLLAGPGGLGMFATV 235
Query 232 EGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGG 291
GI +Q+ + W++ + PY++A+ ++ + + + Q++ + +
Sbjct 236 AGI-SQRAPVRWSENVIGAAVCFPYVVALDDEFITVHSMLDQQQKQTLPFKEGHILQDFE 294
Query 292 SNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNL 351
+I VA++ V+ L+P+P+ +IQ LL + E AL LA+ + +++ Q+ + + L
Sbjct 295 GRVI-VATSKGVYILVPLPLEKRIQDLLASHRVEEALVLAKGARRNIPKEKFQVMYRRIL 353
Query 352 --YAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAEL 409
F F Q +F ++ ++F D ++ LYP LLPT +P P+ A+L
Sbjct 354 LQAGFIQFAQLQFLKAKELFRSGQLDVRELISLYPLLLPTSSSFTRSHP---PLHEFADL 410
Query 410 EKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYL 469
+ D + + + L+ LN+ + T K + IDT LLK Y
Sbjct 411 NQLTQGDQDKVAKCKRFLMSYLNE----------VRSTEVANGYK---EDIDTALLKLYA 457
Query 470 HTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV-----D 524
+ + LL E N C + +S L+K KY L +LY A+Q+ V D
Sbjct 458 EADHDSLLDLLVTE-NFCLLPDSAAWLEKHKKYFALGLLYHYNHQDAAAVQLWVSIVNGD 516
Query 525 QSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDL--PEVES 582
S L +E V +L + + + L++ ++ WVL+ E G+++FT+ +
Sbjct 517 IQDSTRSDL--YEYIVDFLTY--STDPDLVWRHADWVLQRSQEVGVQVFTKRPLDEQQSG 572
Query 583 LPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFP 642
D ++ L + + L + YLEH++ +H L LY ++V P
Sbjct 573 FNPDDIISCLKKYPQAL-VKYLEHLVTERRLQKEEYHTHLAVLYLDEVL-------QQRP 624
Query 643 AGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKH 702
+++ E+ E + KL L+ S Y L+ GL E A+L G++ +H
Sbjct 625 CTP------DKDAEVTETQAKLRRLLQESDLYRVHFLMDRTRGAGLPLESAILHGKLEQH 678
Query 703 EQALFIYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLEL 761
E+AL I VH L D AE+YC + R+ + ++ LL +YL P GP
Sbjct 679 EEALHILVHELADFPAAEDYCLWRSEGRDPPYRQRLFHLLLAVYLGP------GPAA--- 729
Query 762 LEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVL 821
A AA+ +L H + D + L LLP + +R FL + ++ +R QV
Sbjct 730 ---PARTVAAVDLLNRHAVEFDAAQVLQLLPGTWSVQLLRPFLMGAMRDSIHARRTTQVA 786
Query 822 KNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SK 879
L +E L + +++ + +++EK+C +C+ F RYPNG +VH C S+
Sbjct 787 VGLARSENLIYKYDKMKLKGSSVRLSDEKLCQMCQNPFLEPVFVRYPNGGLVHTHCAASR 846
Query 880 EVNPAD 885
P+
Sbjct 847 HTEPSS 852
>sp|Q1ZXS5|VPS39_CAEEL Vacuolar protein sorting-associated protein
39 homolog OS=Caenorhabditis elegans OX=6239 GN=vps-39
PE=1 SV=1
Length=926
Score = 798 bits (2061), Expect = 0.0, Method: Composition-based stats.
Identities = 286/946 (30%), Positives = 478/946 (51%), Gaps = 93/946 (10%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWE--EWLLVGTKQGHLLLYRIRKDVVPADVASPESGS 58
M+DA+ P + +LP+++ CLA E + LL G + GHL Y I S
Sbjct 1 MYDAYTPCEVALRLPVEVTCLAFQESNQTLLAGGRAGHLYAYTI---------------S 45
Query 59 CNRFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLT--FQQITTVSKAK 115
NR L K+F KK + ++ V + +L+ + + + H L ++ T + K K
Sbjct 46 ANRRGFELTNICKSFHKKAVMELKVCQREDLLLCVSDGQLMAHKLSDPEYKVETLIHKVK 105
Query 116 GASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR----EFHELQGDF--SVPDVPKS 169
F +G+ L + V+ +KKL L+ W ++ EF E+ D+ D P S
Sbjct 106 PVQTFA-RFSPKTSGD--LYVIVSSRKKLYLFKWGEKDGHKEFIEVALDYNPVFLDTPTS 162
Query 170 MAWCENSICVGFKRDYYLIRVD--------GKGSIKELFPT------GKQLEPLVAPLAD 215
+ + + +Y+ + + +GS E + +P + P+ D
Sbjct 163 IRCVGEMVFFSVRNEYFSMTMQKDKTTTSPSEGSTPEGWNGFVTRLLNFNCQPGIVPMID 222
Query 216 GK-VAVGQDDLTVVLNEEGICTQKC------ALNWTDIPVAMEHQPPYIIAVLPR-YVEI 267
+ VA ++++ V + I Q+ ++++P+ + + PY++ +L + VE+
Sbjct 223 RRRVAFVRNEIVVTTD---IWGQRPANVLSDEYKFSEVPMQIVYDSPYLVGMLSKGRVEV 279
Query 268 RTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRL-IPVPMATQIQQLLQDKQFEL 326
R+ LVQ++ L + + SG ++VA+ +W L + + L+Q++ FEL
Sbjct 280 RSIFDGQLVQTMSLPKAMTLCSGARGQVFVAALSDIWILDTSQNLRKNVSHLIQERHFEL 339
Query 327 ALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMG---LY 383
A+QLAE +S+ ++Q IK A NLF QK+FDES +F ++ TD + V+ ++
Sbjct 340 AIQLAE---NSNLFAEEQKLEIKKKAALNLFNQKKFDESFALFGEIKTDISEVLSIIRMF 396
Query 384 PDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPL 443
P+LLP ++ + +P + +A LAL YL++ R++ K + + S+
Sbjct 397 PELLPDGFQSMTGVVSDMPA---NDRMRALLALGSYLSEIRTEHAKHIELYNRLYSSGAA 453
Query 444 MEGTPTIKSKKKL-LQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKY 502
+ K+K L L+++DTTLLKCY+ T LV L+RL++N C E+++ +L+ +
Sbjct 454 KKTDEDEKAKLLLTLRVVDTTLLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRL 513
Query 503 SELIILYEKKGLHEKALQVLVDQSKKANSPL---KGHERTVQYLQHLGTENLHLIFSYSV 559
L ILYE + HE AL + +DQS + ++ ++ V+YLQ LG NL LI Y+
Sbjct 514 RSLFILYETRKKHEMALDLFIDQSSRPDADPFFDDAIQQIVEYLQSLGNSNLPLILKYAK 573
Query 560 WVLRDFPEDGLKIFTEDLPEV-ESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRF 618
WVL E G++IFT D E+ +L R V+ FL IPYLEH+I WEE S F
Sbjct 574 WVLAKNLEAGVQIFTSDETEMARNLNRKAVVEFLKSECPDALIPYLEHVIFKWEEPSSYF 633
Query 619 HNCLIQLYCEKVQGLMKEYLLSFP---AGKTPVPAGEEEGELGEYRQKLLMFLEISSYYD 675
H L++ Y +V L K+Y+ +FP + + AG+E+GELG YR++LL FLE+S Y
Sbjct 634 HETLLEFYVARVNTLFKDYVHAFPDAFSDENITRAGDEDGELGLYRKRLLKFLEVSHSYS 693
Query 676 PGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNK 735
P ++ EERAL+LGR+ +HEQAL IYV+ LK+ AEEYC +Y+ + + N
Sbjct 694 PQTVLLQLAPHAFYEERALILGRLKQHEQALAIYVNTLKNVPAAEEYCRLYYNAHDETNS 753
Query 736 DVYLSLLRMYLSP--PSIHCL---------GPIKLELLEPKA----------NLQAALQV 774
VYL L R + P +H + G + ++ E ++ A+++
Sbjct 754 QVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTSSYQPDVNTAIKI 813
Query 775 LELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQE 834
L H K+DT ALN+LPA T + + + V++ ++ ++ K++ + E
Sbjct 814 LAKHADKIDTVGALNMLPATTPLRVVFSAINAVIQTTGRQASTRKMEKSVSQCAMSKKLE 873
Query 835 ERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKE 880
+ Q K I+ C+VC+KKI SAF RYP+G + H +C +
Sbjct 874 RKNKAQSTKIIVNFSSECVVCEKKIAVSAFVRYPDGRLAHLYCHND 919
>sp|A4IG72|TGFA1_DANRE Transforming growth factor-beta receptor-associated
protein 1 homolog OS=Danio rerio OX=7955 GN=tgfbrap1
PE=2 SV=1
Length=863
Score = 791 bits (2042), Expect = 0.0, Method: Composition-based stats.
Identities = 224/902 (25%), Positives = 401/902 (44%), Gaps = 82/902 (9%)
Query 3 DAFEPVPILEKLPL-------QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPE 55
AF+ VP +E+ + I+C+ + L +GT + + + + +
Sbjct 4 KAFDLVPAVEREQVMGEKVRINIECIECCGQHLYLGTNDCFIHHFLLEEHTTAKGKLAFN 63
Query 56 SGSCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQI-TTVSKA 114
+ L K + ++ S + L+ L ++ I V D++T + + T +K
Sbjct 64 AQK-------LLHKYLGLKKPVVELKAASALERLIVLCDSAITVVDMVTLEPVPTGGAKL 116
Query 115 KGASLFTCDLQHTETGEEVLRMCV--AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAW 172
KG + F + + M V A ++ +Q+ + + ++ + + P+ P +++
Sbjct 117 KGVTAFCINENPVTGDAFCVEMAVVLARRRAVQICTVHE-DRVQMLKEVTTPEQPCALSL 175
Query 173 CENSICVGFKRDYYLIRVDGKGSIKELFPTG-KQLEPLVAPLADGKVAVG-QDDLTVVLN 230
+IC+ Y ++ G+ ++LFP ++ +P+V + + + L + N
Sbjct 176 DGYNICLALSTQYMILNY-STGASQDLFPYDCEERKPIVKRIGREEFLLAAPGGLGMFAN 234
Query 231 EEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSG 290
EGI +Q+ ++W++ +A PY++A+ +V + + + L Q++ + + +
Sbjct 235 AEGI-SQRAPVSWSENVIAAAVCFPYVVALDEGFVTVHSMLDQQLKQTLSFRDGQLLQDF 293
Query 291 GSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKN 350
++ VAS+ V+ L+P+P+ QIQ LL + E AL L E + +++ QI H +
Sbjct 294 EGKVV-VASSKAVYMLVPLPLERQIQDLLASHRVEEALTLTEAAQRNIPKEKYQILHRRI 352
Query 351 L--YAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAE 408
L F F Q +F E+ + F K D ++ LYP LLP +P P+ A+
Sbjct 353 LQQAGFIQFGQLQFLEAKEHFRKGQLDVRELISLYPLLLPASSSFTRCHP---PLHEFAD 409
Query 409 LEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCY 468
L HL D +K + + L H+ +S + G + +DT LLK Y
Sbjct 410 LN--HLTQGD--QEKVQRFKRFLISYLHEVRSSDIANG---------FHEDVDTALLKLY 456
Query 469 LHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV----- 523
T+ + LL E N C + +S L+K HKY L +LY G ALQ+ V
Sbjct 457 AETSHESLLDLLASE-NACLLADSAPWLEKHHKYYALGLLYHYNGQDAAALQMWVKIVNG 515
Query 524 DQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVE-- 581
D L E V +L NL L++ ++ W L+ + G++IFT+ E
Sbjct 516 DLQDSTRPDLF--EYVVDFLSFCS--NLDLVWRHADWALQKDQKIGVQIFTKRPTSEERR 571
Query 582 -SLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLS 640
L D V+ +L ++ + L + LEH++ + ++H L LY EKV GL+
Sbjct 572 GQLNADDVITYLQKHSQALLLY-LEHLVLEKKLQKEKYHTHLAVLYAEKVLGLISR---- 626
Query 641 FPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLE-ERALLLGRM 699
P+ EE +L RQKL L+ S+ Y L+ LL ERA L G++
Sbjct 627 --------PSTSEE-QLSAARQKLQRLLKESNLYRVQLLLGKIQDSELLLLERATLHGKL 677
Query 700 GKHEQALFIYVHILKDTRMAEEYC-HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIK 758
+H++AL + VH LKD+ AEEYC ++ ++++ LL +YL P
Sbjct 678 EEHDKALHVLVHQLKDSSAAEEYCSWASASQDSSYRQNLFHQLLSVYLDPD--------- 728
Query 759 LELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFN 818
+ A AA+ +L H D + L LLP + + +R FL + + +
Sbjct 729 ---VPGGAQTVAAVDLLNRHAEVFDAVRVLKLLPEDWSLPLLRPFLCGAMRATVHARCTS 785
Query 819 QVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCS 878
QV L A+ L++ +R+ ++ +++E+K C +C A P G VH C
Sbjct 786 QVALGLARAQNLQLLHDRLKYRGGPVLVSEKKGCQLCHNTFSEPDCACLPGGTPVHINCV 845
Query 879 KE 880
+
Sbjct 846 AK 847
>sp|Q8L5Y0|VPS39_ARATH Vacuolar sorting protein 39 OS=Arabidopsis
thaliana OX=3702 GN=VPS39 PE=1 SV=1
Length=1000
Score = 729 bits (1881), Expect = 0.0, Method: Composition-based stats.
Identities = 263/1014 (26%), Positives = 470/1014 (46%), Gaps = 165/1014 (16%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
+H+A++ +L+ P +ID + ++ L G G L +Y P + ++ + +
Sbjct 2 VHNAYDSFQLLKDCPARIDAVESYGSKLFAGCYDGSLRIYS------PPESSASDPSELH 55
Query 61 RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASL 119
+ LEK+ FSKK I + V++ ++L+SL E+ I H L + + ++KAKGA+
Sbjct 56 QETYVLEKTVAGFSKKPIVAMEVLASRELLLSLSES-IAFHGLPNLETVAVITKAKGANA 114
Query 120 FTCDLQHTETGEEVLRMCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSIC 178
++ D + +C + +K++ ++ F E++ D+ VPD KS++WC +IC
Sbjct 115 YSWDDRRG-------FLCFSRQKRVCVFKHDGGGGFVEVR-DYGVPDTVKSISWCGENIC 166
Query 179 VGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQK 238
+G K++Y ++ G++ E+FP+G+ PLV L G++ +G++++ V +++ G Q
Sbjct 167 LGIKKEYVILNT-ANGTLSEVFPSGRVAPPLVISLPSGELILGKENIGVFVDQNGKLLQT 225
Query 239 CALNWTDIPVAMEHQPPYIIAVLPRYVEIRTF-EPRLLVQSIELQRPRFITSGGSNIIYV 297
+ W++ P ++ Q PY IA+LPR VE+R P L+Q+I LQ R + +N + V
Sbjct 226 ERICWSEAPTSIVIQNPYAIALLPRRVEVRLLRSPYPLIQTIVLQNIRRLVK-SNNAVIV 284
Query 298 ASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAE-MKDDSDSEKQQQIHHIKNLYAFNL 356
++ V+ L PV + QI QL FE AL L + + D S + + I +A L
Sbjct 285 GLDNSVYVLFPVSIGAQIVQLTASGNFEEALALCKVLPPDESSLRAAKESSIHTRFAHYL 344
Query 357 FCQKRFDESMQVFAKLGTDPTHVMGLYPDLL--------------------------PTD 390
F ++E+M+ F D THV+ +YP ++ +
Sbjct 345 FENGSYEEAMEHFLASQVDITHVLSMYPSIILPKTTIIPQPDKMVDISGDEASLSRGSSG 404
Query 391 YRKQLQYPNP---LPVLSGAELEK------AHLALIDYLTQKRSQLVKKLNDSDHQSSTS 441
++ +P L A+LE +ALI YL ++R +++K + S
Sbjct 405 ISDDMESSSPRYFLESEDNADLESKKMSHNTLMALIKYLLKRRPAVIEKATSEGTEEVIS 464
Query 442 PLMEGT-------------------PTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRL 482
+ T P +++ I+DT LL+ LHT + A L
Sbjct 465 DAVGKTYGANDSSKSKKSSKGRGMIPLNSGAREMAAILDTALLQALLHTGQSGAAIELLK 524
Query 483 ENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVL--------VDQSKKANSPLK 534
N+ ++ E +L K+ YS L+ L++ +H +AL++L +QS+ + +
Sbjct 525 GVNYSDVKICEEILMKSKNYSALLELFKSNSMHHEALKLLNQLADESKTNQSQTDVTQIF 584
Query 535 GHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIE 594
E ++YL+ L + L+ YS+ VL P + +F ++ D V +L +
Sbjct 585 SPELIIEYLKPLCRTDPMLVLEYSMLVLESCPTQTIDLFLSG-----NISADLVNSYLKQ 639
Query 595 NFKGLAIPYLEHIIHVWEETGS-RFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653
+ + YLE ++ + + S N ++Q+Y +V L A K+ +E
Sbjct 640 HAPNMQGRYLELMMAMNDTAVSGNLQNEMVQIYLSEV--------LDLYAAKSAQQKWDE 691
Query 654 EGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHIL 713
+ E R+KLL LE S Y P L+ P D L EERA++LG+M +HE AL IYVH L
Sbjct 692 KDHPPE-RKKLLSALESISGYSPQPLLKRLPRDALYEERAVILGKMNQHELALSIYVHKL 750
Query 714 KDTRMAEEYCHKHYDR-----NKDGNKDVYLSLLRMYLSPPS--------IHCLGPIK-- 758
+A YC + Y+ + + ++YL++L++YL+P I LG +
Sbjct 751 HAPDLALAYCDRIYESVTYLPSGKPSSNIYLTVLQIYLNPKKSAKDFAKRIVALGSFESS 810
Query 759 ------LELLEPKANLQAALQVLELHH--------------------------------- 779
+L KA + +++ +
Sbjct 811 DTTKMMDSVLSSKAKGGRSKKIVAIEGAEDMRVGLSSSTDSGRSDVDTEEPLEEGDSTVM 870
Query 780 ------------SKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHA 827
+++ +AL LLP T+++++ FL +L +++ R V+K+L +
Sbjct 871 ISEVLDLLSQRWERINGAQALKLLPRETKLHNLLPFLAPLLRNSSEAHRNFSVIKSLRQS 930
Query 828 EFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNG-VVVHYFCSKE 880
E L+V+EE H++ +T E +C +C KKIG S FA YPNG +VH+ C ++
Sbjct 931 ENLQVKEELYKHRKGVAQVTSESMCSLCNKKIGTSVFAVYPNGKTLVHFVCFRD 984
>sp|O13955|VAM6_SCHPO Vacuolar morphogenesis protein 6 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=vam6
PE=3 SV=1
Length=905
Score = 665 bits (1716), Expect = 0.0, Method: Composition-based stats.
Identities = 228/962 (24%), Positives = 398/962 (41%), Gaps = 141/962 (15%)
Query 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN 60
MH AF +LE +++C+ + V G L Y+I + E
Sbjct 1 MHRAFSLYRVLELSKARVECVFELGGLVYVSNSNGDLDSYKIYNN---------EEEEAA 51
Query 61 RFEVTLEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDLLTFQQITT-VSKAKGAS 118
F + NF+KK I ++ + I +L ++ +YV+ + TF+++ + + +
Sbjct 52 DFVMEHVDVYPNFTKKPITKVVSCATQDIFYALSDSQVYVYQISTFKKLFSFGAHCQNMC 111
Query 119 LFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCEN-SI 177
L+ +L + ++ KK L++Y + L S+ D P+S+AW I
Sbjct 112 LYGDEL-----------IVLSSKKNLEIYEIQKNSKPNLTKTISLNDRPRSLAWVSPTMI 160
Query 178 CVGFKRDYYLIRVDGKGSIKELFPTGKQLEPL-----------------VAPLADGKVAV 220
V D+ + + I L +Q L + ++D +V +
Sbjct 161 LVSLSNDFCAVNTE-TSRISSLNLAWQQSSSLGLGISYIGMSIKSNKLHITRISDDEVLL 219
Query 221 GQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIE 280
+D +++N + + + L W +P A+ + PYII + +Y+ I E ++Q I
Sbjct 220 SKDSQGLLVNLKSLQVSRNPLRWPTVPQAVIYNSPYIITLHNQYIYIWNKETYAMIQQIG 279
Query 281 LQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQ-LAEMKDDSDS 339
+ S N + SN +VW L P + QI+ LL + A+ L+++
Sbjct 280 ISNIYSTFSCHKNTFF-TSNSYVWILTPEDFSNQIEALLNTENLNEAISVLSQITVSQFP 338
Query 340 EKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPN 399
++ + K A F +D +M++F+++ P+ V+GL+P LL +Y + +
Sbjct 339 KRDYYLRITKREKALRSFSSGDYDLAMRLFSEISESPSTVLGLFPGLLDNNYSDAISILS 398
Query 400 PLP---------------------------VLSGAELEKAHLALIDYLTQKRSQLVKKL- 431
P +S K +L YLT R + + L
Sbjct 399 MAPSQNESIESNVLFPGNHSNSQTDLRNGDAVSTVANNKRLRSLSTYLTDSRRKANRFLS 458
Query 432 NDSDHQ--SSTSPLMEGTPTIKSKKKLLQI---IDTTLLKCYLHTNVALVAPLLRLENNH 486
D +H + + T+ +K+KL +I IDTTL Y+ ++ ALV LLRL N
Sbjct 459 YDEEHYFLQKKNLFLNADGTLVAKEKLEKIAVQIDTTLFLIYMISSPALVGSLLRLP-NR 517
Query 487 CHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLK---------GHE 537
C E L A Y EL+ Y K LHE AL +L + L +E
Sbjct 518 CETSVVETNLLSAKMYRELVEYYYGKSLHEAALDLLTKLCDEPTDTLSLKGKSNTTSKYE 577
Query 538 RTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFK 597
+ YL+ L E HLIF YS L + P++ + IF ++ E ++ + VL +L
Sbjct 578 PILSYLEKLSPELDHLIFKYSRVPLSEDPQNSIVIFIDENSEASTISKGVVLKYLETISY 637
Query 598 GLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGEL 657
++I YLE ++ + + F L LY +++ L E F + +
Sbjct 638 KVSIIYLEKLLLDNKFNDTVFPTRLALLYLKRILEL--EETTDF----------KNQEVF 685
Query 658 GEYRQKLLMFLEISSYYDPGRLICDFPF-DGLLEERALLL-GRMGKHEQALFIYVHILKD 715
+ +KL +L S YD ++ + D L +++L R+ +H+ AL +Y+ IL D
Sbjct 686 KQTIEKLEDYLTNSKQYDANVVLQEINSQDEFLSTVSIILYRRLSRHQDALDVYLKILND 745
Query 716 TRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQA----A 771
A YC+ Y + DG + Y LL E N ++
Sbjct 746 WEGALSYCNSVY--SIDGETEPYYMLLA-------------------EISKNYKSGSLNI 784
Query 772 LQVLELHHSKLDTTKALNLLPANTQIN--------DIRIFLEKVLEENAQKKRFNQVLKN 823
L + + S+LD + LLP N + R E++ + Q K + + L++
Sbjct 785 LDFITKYSSRLDLNRVFPLLPKNISMKSYHSLFSSQFRQLFEELSNKETQSKLYQKRLED 844
Query 824 LLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNP 883
L EE + K +IT EK C+ C K++G S + +P+G VVHY C+K+
Sbjct 845 L--------NEELTKVRSEKVVITREKTCLFCHKRLGKSVISIFPDGSVVHYGCAKKYVS 896
Query 884 AD 885
++
Sbjct 897 SN 898
>sp|F4I312|VPS3_ARATH Vacuolar sorting protein 3 OS=Arabidopsis
thaliana OX=3702 GN=VPS3 PE=1 SV=2
Length=984
Score = 598 bits (1541), Expect = 0.0, Method: Composition-based stats.
Identities = 188/857 (22%), Positives = 324/857 (38%), Gaps = 128/857 (15%)
Query 116 GASLFTCDLQHTETGEEVLR-----MCVAVKKKLQLYFWKDREFHELQGDFSV------P 164
GA D++ ++ E ++ VA+ +++ L + E L G F V
Sbjct 150 GAGNLVSDVRGNDSRHERVQQGHYVFAVAIGERMLLIELQCAEKEGLSGSFVVLKEILGI 209
Query 165 DVPKSMAWCENSICVGFKRDYYLIR-VDGKGSIKELFP--TGKQLEPLVAPLADGKVAVG 221
K++ W ++ + G + Y LI V G + P +G L L+ + KV +
Sbjct 210 GGIKTLVWLDDYVIAGTVKGYSLISCVTGLSGVIFTLPDVSGPPLLKLLC--KEWKVLLL 267
Query 222 QDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIEL 281
D++ VV++ G +L + P ++ Y++ V +EI + VQS+
Sbjct 268 VDNVGVVVDTNGQPIG-GSLVFRRRPDSVGELSFYLVTVGDGKMEIHQKKSGACVQSVSF 326
Query 282 Q----RPRFITS---GGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMK 334
P + + G N++ V + + VP QI+ LL+ K++ + L E
Sbjct 327 GPQGCGPSLLAADEAGDGNLLVVTTLSKLIFYRRVPYEEQIKDLLRKKRYRETISLVEEL 386
Query 335 DDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKL-GTDPTHVMGLYPDLLPTDYRK 393
D + + + + L RF+E++ F K +P+ V +P ++ R
Sbjct 387 DSQGEISKDMLSFLHAQIGYLLLFDLRFEEAVNQFLKSEKMEPSEV---FPFIMRDPNRW 443
Query 394 QLQYP-------------------NPLPVLSGAE-LEKAHL-------------ALIDYL 420
L P N L + A L KA + + D L
Sbjct 444 SLVVPRNRYWGLHPPPAPFEDVVDNGLMAIQRANFLRKAGMDTPVDEEFFSDPPSRADLL 503
Query 421 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL 480
+ + L S + T P+ EG IDT L+ Y N L
Sbjct 504 DSAIKNITRYLEISREKGLTLPVREG-------------IDTLLMLLYRALNRVEDMENL 550
Query 481 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPL-KGHERT 539
N+C +EE E +L ++ L LY KG+ KAL + +K +S L + +
Sbjct 551 ASSGNNCVVEELETLLTESGHLRTLAFLYATKGMGAKALAIWRLFTKNYSSGLWQDSDDL 610
Query 540 VQYLQHLG--------------------TENLHLIFSYSVWVLRDFPEDGLKIFTEDLPE 579
V YL + L + W+ P +++ T D
Sbjct 611 VPYLHDNELIRLSGKEAAAAEAARILEEPCDPELALQHLSWIADVNPLFAIQVLTSD-KR 669
Query 580 VESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLI------QLYCEKVQGL 633
E L ++V+ + + Y + +I + T + H L C +VQ
Sbjct 670 TEELSPEQVIQAIDPKKVEIIQRYFQWLIEERDYTDPQLHTSYALSLARSALECVEVQNG 729
Query 634 MKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERA 693
++E + + G + R++L FL+ S YDP ++ L E+A
Sbjct 730 IQEADVPNGSEAHDSNVGSISLFEVDVRERLQAFLQSSDLYDPEEILELVEGSELWLEKA 789
Query 694 LLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHC 753
+L R+GK L I L+D AE+YC + G D ++ LL MYL P +
Sbjct 790 ILYRRIGKETLVLQILALKLEDCAAAEQYCVEI------GRPDAFMQLLDMYLDPQNGK- 842
Query 754 LGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQ 813
EP +AA+++L H LD + L+ L + + + ++L
Sbjct 843 ---------EPM--FKAAVRLLHNHGESLDPLQVLDKLSPDMPLKLASDTILRMLRARVH 891
Query 814 KKRFNQVLKNLLHA----EFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPN 869
R Q++ N+ A L EER H Q I +E +C C ++G FA YP+
Sbjct 892 HHRQGQIVHNISRALDVDSRLARLEERSRHMQ----INDESLCDSCYARLGTKLFAMYPD 947
Query 870 GVVVHYFCSKEVNPADT 886
+V Y C + + + +
Sbjct 948 DTIVCYKCYRRLGESKS 964
>sp|Q07468|VAM6_YEAST Vacuolar morphogenesis protein 6 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=VAM6 PE=1 SV=1
Length=1049
Score = 349 bits (894), Expect = 9e-104, Method: Composition-based stats.
Identities = 133/551 (24%), Positives = 221/551 (40%), Gaps = 89/551 (16%)
Query 370 AKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVK 429
K + + P LL R L Y + + L+ S++
Sbjct 524 LKEAEEVKETYDIPPHLL---NRWCLPYLT--------DTRRHLQNLLSKENDDESRITW 572
Query 430 KLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHI 489
D + + S + +L +IDT L KCYL+ N +V P +R+E NHC
Sbjct 573 CYRDREIKQSFDFFLISNHDDVDLNTMLTLIDTVLFKCYLYYNPPMVGPFIRVE-NHCDS 631
Query 490 EESEHVLKKAHKYSELIILYEKKGLHEKALQVL---VDQSKKANSPLKGHERT------- 539
LK H + +LI Y K+G HE+AL+ L VD+ + N+ K ++
Sbjct 632 HVIVTELKIRHMFKDLIDFYYKRGNHEEALKFLTDLVDELENDNTDQKQRQKIDHGVKIL 691
Query 540 -VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLK-----IFTEDLPEVESLPRDRVLGFLI 593
+ YL+ L L +IF+Y+ W+L + D +K IF D S +V G++
Sbjct 692 VIYYLKKLSNPQLDVIFTYTDWLL-NRHNDSIKEILSSIFFYDSQACSSRDHLKVYGYIK 750
Query 594 ENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEE 653
+ K LAI YLE I + G++ H LI+LY E +
Sbjct 751 KFDKLLAIQYLEFAISTFRLEGNKLHTVLIKLYLENLD---------------------- 788
Query 654 EGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALL---------------LGR 698
+ R KL LE +S Y+P R I D + L L +
Sbjct 789 ---IPSTRIKLKSLLETTSVYEP-RTILKLLNDAIESGSDQLPTNQLNFVKYLKIFPLSK 844
Query 699 MGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIK 758
+ H++A+ I + + D + A YC+ Y + +++ LL +Y SI+
Sbjct 845 LENHKEAVHILLDEIDDYKAATSYCNDVYQSDSTKGEEL---LLYLYSKLVSIY------ 895
Query 759 LELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFN 818
+ N + L L+ H SKL++ + LP + + DI + ++L+++ K
Sbjct 896 ----DSNRNSKLILNFLQDHGSKLNSAEIYKNLPQDISLYDIGRVVSQLLKKHTSKMDET 951
Query 819 QVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGN------SAFARYPNGVV 872
++ K LL E + + ++++ C +CKK I N S F R ++
Sbjct 952 RLEKALLQVELVATTYKLNERMSSYGVLSDSHKCPICKKVISNFGTDSISWFTREGRNII 1011
Query 873 VHYFCSKEVNP 883
HY C K +
Sbjct 1012 THYNCGKVLQE 1022
>sp|Q7TT50|MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta
OS=Mus musculus OX=10090 GN=Cdc42bpb PE=1 SV=2
Length=1713
Score = 187 bits (475), Expect = 2e-47, Method: Composition-based stats.
Identities = 72/313 (23%), Positives = 117/313 (37%), Gaps = 47/313 (15%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSK----AKGASLFTCDLQHTETG 130
KK+ QI + + KI + L N +VH L + K C L T T
Sbjct 1280 KKVYQIELAPKEKIAILLCGRNHHVH-LYPWSSFDGAEASNFDIKLPETKGCQLIATGTL 1338
Query 131 EEVLRMC--VAVKKKLQLYFWK-DREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYL 187
+ C VAVK+ + Y + + FH + P + MA ++ +CVG+ + L
Sbjct 1339 RKSSSTCLFVAVKRLILCYEIQRTKPFHRKFSELVAPGHVQWMAVFKDRLCVGYPSGFSL 1398
Query 188 IRVDGKGSIKELF-PTGKQLEPLVAPLADGKV---------AVGQDDLTVVLNEEGICTQ 237
+ + G G +L PT L L D + + + ++ +G ++
Sbjct 1399 LSIQGDGPPLDLVNPTDPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGRRSR 1458
Query 238 KCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSGGS- 292
L W PVA P + + V Y ++RT E VQ+I L+R R + S GS
Sbjct 1459 MQELMWPAAPVACSCSPTH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSDGSL 1514
Query 293 --------NIIYVASNHFVWRLIPVP-----MATQIQQLLQDKQF------ELALQLAEM 333
+IY N F ++ VP Q+ + ++F E LQ
Sbjct 1515 NLLGCEPPRLIYF-KNKFSGTILNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRRE 1573
Query 334 KDDSDSEKQQQIH 346
+ + I
Sbjct 1574 MLRDPELRSKMIS 1586
>sp|Q9Y5S2|MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta
OS=Homo sapiens OX=9606 GN=CDC42BPB PE=1 SV=2
Length=1711
Score = 186 bits (472), Expect = 5e-47, Method: Composition-based stats.
Identities = 70/315 (22%), Positives = 119/315 (38%), Gaps = 52/315 (17%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKG------ASLFTCDLQHTE 128
KK+ QI + + KI++ L N +VH +++ A+G C L T
Sbjct 1279 KKVHQIELAPREKIVILLCGRNHHVH----LYPWSSLDGAEGSFDIKLPETKGCQLMATA 1334
Query 129 TGEEVLRMC--VAVKKKLQLYFWK-DREFHELQGDFSVPDVPKSMAWCENSICVGFKRDY 185
T + C VAVK+ + Y + + FH + P + +A + +CVG+ +
Sbjct 1335 TLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGF 1394
Query 186 YLIRVDGKGSIKELF-PTGKQLEPLVAPLADGKVAVGQDD---------LTVVLNEEGIC 235
L+ + G G L P L L D AV + + + ++ +G
Sbjct 1395 CLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLCFSHMGLYVDPQGRR 1454
Query 236 TQKCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSGG 291
+ L W PVA P + + V Y ++RT E VQ+I L+R R + S G
Sbjct 1455 ARAQELMWPAAPVACSCSPTH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSEG 1510
Query 292 S---------NIIYVASNHFVWRLIPVP-----MATQIQQLLQDKQF------ELALQLA 331
+ +IY + F ++ VP Q+ + ++F E LQ
Sbjct 1511 TLNLLNCEPPRLIYF-KSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQR 1569
Query 332 EMKDDSDSEKQQQIH 346
+ + I
Sbjct 1570 REMLRDPELRSKMIS 1584
>sp|Q7TT49|MRCKB_RAT Serine/threonine-protein kinase MRCK beta
OS=Rattus norvegicus OX=10116 GN=Cdc42bpb PE=1 SV=1
Length=1713
Score = 184 bits (466), Expect = 3e-46, Method: Composition-based stats.
Identities = 70/316 (22%), Positives = 117/316 (37%), Gaps = 53/316 (17%)
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKA-------KGASLFTCDLQHT 127
KK+ QI + + K+++ L N +VH T+ A K C L T
Sbjct 1280 KKVYQIELAPKEKLILLLCGRNHHVH----LYPWTSFDGAEASNFDIKLPETKGCQLIAT 1335
Query 128 ETGEEVLRMC--VAVKKKLQLYFWK-DREFHELQGDFSVPDVPKSMAWCENSICVGFKRD 184
T + C VAVK+ + Y + + FH + P + MA ++ +CVG+
Sbjct 1336 GTLRKSSSTCLFVAVKRLVLCYEIQRTKPFHRKFNEIVAPGHVQWMAMFKDRLCVGYPSG 1395
Query 185 YYLIRVDGKGSIKELF-PTGKQLEPLVAPLADGKV---------AVGQDDLTVVLNEEGI 234
+ L+ + G G +L P L L D + + + ++ +G
Sbjct 1396 FSLLSIQGDGQPLDLVNPADPSLAFLSQQSFDALCAVELKSEEYLLCFSHMGLYVDPQGR 1455
Query 235 CTQKCALNWTDIPVAMEHQPPYIIAVLPRY----VEIRTFEPRLLVQSIELQRPRFITSG 290
++ L W PVA + + V Y ++RT E VQ+I L+R R + S
Sbjct 1456 RSRTQELMWPAAPVACSCSSSH-VTVYSEYGVDVFDVRTME---WVQTIGLRRIRPLNSD 1511
Query 291 GS---------NIIYVASNHFVWRLIPVP-----MATQIQQLLQDKQF------ELALQL 330
GS +IY N F ++ VP Q+ + ++F E LQ
Sbjct 1512 GSLNLLGCEPPRLIYF-KNKFSGTVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQ 1570
Query 331 AEMKDDSDSEKQQQIH 346
+ + I
Sbjct 1571 RREMLRDPELRSKMIS 1586
>sp|Q54EH3|Y1510_DICDI GTPase-activating protein DDB_G0291510
OS=Dictyostelium discoideum OX=44689 GN=DDB_G0291510 PE=4 SV=1
Length=1031
Score = 171 bits (433), Expect = 2e-42, Method: Composition-based stats.
Identities = 48/195 (25%), Positives = 94/195 (48%), Gaps = 10/195 (5%)
Query 86 FKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQ 145
IL + E++I V ++ + T KG D + E E++ + V +KK L
Sbjct 683 ENILTVIGEDSIKVKKIVGTKGCTVYGYTKG------DNEGQE--EDITLLYVGLKKTLL 734
Query 146 LYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQ 205
LY W EF + + + ++ A ICVG ++++ LI + + +IKEL+
Sbjct 735 LYEWNKGEFVKSRELPLMDNIKTLCAIAPGMICVGIQKEFLLIDIFTQ-TIKELYKKSDS 793
Query 206 LEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYV 265
EP+ A D ++ + +++ + ++E G T++ L W P ++ P Y++ + +
Sbjct 794 -EPVKALSLDNEILLCFNNIGIFVDESGNKTRQFELKWGSTPSSLALVPSYVLGISGPLI 852
Query 266 EIRTFEPRLLVQSIE 280
E+RT ++QS+
Sbjct 853 EVRTLLNGNIIQSLP 867
>sp|Q3UU96|MRCKA_MOUSE Serine/threonine-protein kinase MRCK alpha
OS=Mus musculus OX=10090 GN=Cdc42bpa PE=1 SV=2
Length=1719
Score = 129 bits (324), Expect = 4e-29, Method: Composition-based stats.
Identities = 65/406 (16%), Positives = 152/406 (37%), Gaps = 50/406 (12%)
Query 72 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITT--VSKAKGASLFTCDLQHTET 129
+KKI QI ++ +++ + N +V L + K A C
Sbjct 1250 GDNKKIHQIELIPSDQLVAVISGRNRHV-RLFPMSALDGRETDFYKLAETKGCQTIAAGK 1308
Query 130 GE--EVLRMCVAVKKKLQLYFW-KDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186
+ +CVA+K+++ Y + + H + VP + MA +CVGF+ +
Sbjct 1309 VRHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFL 1368
Query 187 LIRVDGKGSIKELFPTGKQLEPLV----------APLADGKVAVGQDDLTVVLNEEGICT 236
++G+G + + + +++ + + + + + + +G +
Sbjct 1369 RYPLNGEGGPCNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRS 1428
Query 237 QKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS-NII 295
++ L W P + + PY+ V+I +Q++ L++ R + + GS N++
Sbjct 1429 RQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLL 1488
Query 296 YVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHI--KNLYA 353
+ + ++ + +L + + SD+ ++Q + +I K Y+
Sbjct 1489 GLETIRLIYF---------------KNKMAEGDELV-VPETSDNSRKQMVRNINNKRRYS 1532
Query 354 FNLFCQKRFDESMQVFA---------KLGTDPTHVMGLYPDLLPTDYRKQLQYP-NPLPV 403
F + ++R + ++ T+ H+ + P + P NP P
Sbjct 1533 FRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPG---DGIQILKDLPMNPRPQ 1589
Query 404 LSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPT 449
S + I +T+ R + + ++ S S+ S G+
Sbjct 1590 ESRTVF--SGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSAL 1633
>sp|Q5VT25|MRCKA_HUMAN Serine/threonine-protein kinase MRCK alpha
OS=Homo sapiens OX=9606 GN=CDC42BPA PE=1 SV=1
Length=1732
Score = 128 bits (320), Expect = 1e-28, Method: Composition-based stats.
Identities = 65/406 (16%), Positives = 153/406 (38%), Gaps = 50/406 (12%)
Query 72 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITT--VSKAKGASLFTCDL--QHT 127
+KKI QI ++ +++ + N +V L + K + C
Sbjct 1263 GDNKKIHQIELIPNDQLVAVISGRNRHV-RLFPMSALDGRETDFYKLSETKGCQTVTSGK 1321
Query 128 ETGEEVLRMCVAVKKKLQLYFW-KDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186
+ +CVA+K+++ Y + + H + VP + MA +CVGF+ +
Sbjct 1322 VRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFL 1381
Query 187 LIRVDGKGSIKELFPTGKQLEPLVA----------PLADGKVAVGQDDLTVVLNEEGICT 236
++G+G+ + + +A ++ + + + + + + +G +
Sbjct 1382 RYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRS 1441
Query 237 QKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS-NII 295
++ L W P + + PY+ V+I +Q++ L++ R + + GS N++
Sbjct 1442 RQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLL 1501
Query 296 YVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHI--KNLYA 353
+ + ++ + +L + + SD+ ++Q + +I K Y+
Sbjct 1502 GLETIRLIYF---------------KNKMAEGDELV-VPETSDNSRKQMVRNINNKRRYS 1545
Query 354 FNLFCQKRFDESMQVFA---------KLGTDPTHVMGLYPDLLPTDYRKQLQYP-NPLPV 403
F + ++R + ++ T+ H+ + P + P NP P
Sbjct 1546 FRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPG---DGIQILKDLPMNPRPQ 1602
Query 404 LSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPT 449
S + I +T+ R + + ++ S S+ S G+
Sbjct 1603 ESRTVF--SGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSAL 1646
>sp|O54874|MRCKA_RAT Serine/threonine-protein kinase MRCK alpha
OS=Rattus norvegicus OX=10116 GN=Cdc42bpa PE=1 SV=1
Length=1732
Score = 128 bits (320), Expect = 1e-28, Method: Composition-based stats.
Identities = 66/406 (16%), Positives = 152/406 (37%), Gaps = 50/406 (12%)
Query 72 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITT--VSKAKGASLFTCDLQHTET 129
+KKI QI ++ +++ + N +V L + K A C
Sbjct 1263 GDNKKIHQIELIPSDQLVAVISGRNRHV-RLFPMSALDGRETDFYKLAETKGCQTIAAGK 1321
Query 130 GE--EVLRMCVAVKKKLQLYFW-KDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186
+ +CVA+K+++ Y + + H + VP + MA +CVGF+ +
Sbjct 1322 VRHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFL 1381
Query 187 LIRVDGKGSIKELFPTGKQLEPLVA----------PLADGKVAVGQDDLTVVLNEEGICT 236
++G+GS + + + +++ + + + + + +G +
Sbjct 1382 RYPLNGEGSPCNMLHSNDHTLAFITHQPMDAICAVEISNKEYLLCFSSIGIYTDCQGRRS 1441
Query 237 QKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS-NII 295
++ L W P + + PY+ V+I +Q++ L++ R + + GS N++
Sbjct 1442 RQQELMWPANPSSCCYNAPYLSIYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLL 1501
Query 296 YVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHI--KNLYA 353
+ + ++ + +L + + SD+ ++Q + +I K Y+
Sbjct 1502 GLETIRLIYF---------------KNKMAEGDELV-VPETSDNSRKQMVRNINNKRRYS 1545
Query 354 FNLFCQKRFDESMQVFA---------KLGTDPTHVMGLYPDLLPTDYRKQLQYP-NPLPV 403
F + ++R + ++ T+ H+ + P + P NP P
Sbjct 1546 FRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPG---DGIQILKDLPMNPRPQ 1602
Query 404 LSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPT 449
S + I +T+ R + + ++ S S+ S G+
Sbjct 1603 ESRTVF--SGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSAL 1646
>sp|O59796|VPS3_SCHPO Vacuolar protein sorting-associated protein
3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)
OX=284812 GN=vps3 PE=3 SV=2
Length=910
Score = 123 bits (308), Expect = 2e-27, Method: Composition-based stats.
Identities = 123/920 (13%), Positives = 298/920 (32%), Gaps = 147/920 (16%)
Query 18 IDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFSKKI 77
+ +A + L GT+ G + LY + + S ++
Sbjct 19 VTTIALYNNHLYFGTEGGDVFLYNFSNFQLNESPELVKKISLVS------------KSRV 66
Query 78 QQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMC 137
+I + + + V+ Q+ KG F + +E
Sbjct 67 NRILAMPFLGAVFIHHGSFAEVYKEDDLTQLYPSISFKGLVEFC---HPGQRIDEKSTYL 123
Query 138 VAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIK 197
+ L+L ++ ++ + P+ ++ + +C+ + + L+ + +
Sbjct 124 IVTNTHLKLISFQKDGIILVKNELKYPN-IQTARVNGHIVCLVTENSFELLDILTFDTTP 182
Query 198 ELFP--------TGKQLEPLVAPLADGKVAVG---QDDLTVVLNEEGICTQKCALNWTDI 246
LFP G +P++ ++ + + +D + + ++ +G T + L ++
Sbjct 183 -LFPIIKYDSENNGLMYKPMIVLHSNEFLLITGSPKDAIGLFVDSQGNVT-RSTLTFSFY 240
Query 247 PVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQR------PRFITSGG--SNIIY-- 296
P + Y+ A+ ++I LV+SI L+ +TS I+
Sbjct 241 PKHVFSTSHYVFAISSSSLQIIDINTLSLVKSINLKDDESFSFISRLTSVHFCDRQIFSK 300
Query 297 ------VASNHFVWRLIPVPMATQI--------------QQLLQDKQFELALQLAEMKDD 336
+++ + + + +F + + E
Sbjct 301 FSAVNTASTSKTSDTIERASFSKPSFIFLTNKSWGFGAEAHFMNKLEFSITIGDIEAPLR 360
Query 337 SDSEK-----QQ---------QIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGL 382
S++ + Q +++ + A + Q +++ S+ + DP V+ L
Sbjct 361 RVSKRLRNPKKYGITNDVAYLQSAYLEQISALQYWKQGQYENSLSLLETSKIDPRVVISL 420
Query 383 YPDLLPTD---------YRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLV--KKL 431
YPDL ++ + + ++ D TQ++ + +
Sbjct 421 YPDLYHSELSYIAFQGVISFRKSILSVDDTVANVLKSNELFRDTDQYTQRQMIEITKENA 480
Query 432 NDSDHQSSTSPLMEGT---PTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLR---LENN 485
+ + + + S++ ++ ++ +LL YL+ + LE+
Sbjct 481 YIMLMRYLKNYKKNTSISEYLLSSQRDVMLAVEHSLLLLYLNMDDLAAGTKNAKELLESG 540
Query 486 HCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQH 545
+E+ + VL + +Y L +L H+ LQ + ++ ++ ++
Sbjct 541 LTGVEDIKDVLIQKKEYYLLSVLLATVRDHDGVLQTWKKLITGDYEDRRFNDGLIKIREY 600
Query 546 LGT-ENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYL 604
L + ++ W+ + +G ++ D S+ + VL L + + I YL
Sbjct 601 LVNDIEPSTFWEFTTWLCKHDATEGTRVLL-DKTVSGSISAEDVLEHLDSSQDDVLIDYL 659
Query 605 EHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEG--ELGEYRQ 662
+ L++L K+ G + ++ +T + E E Y Q
Sbjct 660 ------VKSNSVTHRALLLKLCVNKLLGSLLDHNDFKNRLETAIETFRELPCMEKPTYAQ 713
Query 663 KLLMFLEISSYYDPGR---------LICDFPFDGLLEERALL------------------ 695
L S + L+ + + + + + +L
Sbjct 714 YLEQLWGDMSDFSTHLSFYYLCSINLMENVEEESIDKIKDILFDIHVDNLYLFPQLEHSF 773
Query 696 LGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLG 755
R +E+AL + V + D + E YC L + +Y P L
Sbjct 774 YKRKKNYEKALSVLVTNIHDYKGGEAYC---------------LQIDDVY--PQCWCNLL 816
Query 756 PIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKK 815
+ + ++ ++L + +P + +N + FL + + NA++
Sbjct 817 EKCISTGDGCSDF--IKELLYRRPFSYTLSYVCEQIPDHWNLNLLADFLCILQKRNAERL 874
Query 816 RFNQVLKNLLHAEFLRVQEE 835
+Q L + + EE
Sbjct 875 NESQTRLTLEKS-LSQNLEE 893
>sp|P53046|ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ROM1
PE=1 SV=2
Length=1155
Score = 119 bits (299), Expect = 3e-26, Method: Composition-based stats.
Identities = 43/173 (25%), Positives = 74/173 (43%), Gaps = 22/173 (13%)
Query 145 QLYFWKDREFHELQG----DFSVPDVPKSMAWCENSICVGFKRDYYLIRV----DGKG-S 195
++ + F + DFSV P S ++ EN IC+G K++ ++ V D G
Sbjct 968 LIFDFNSGNFKKNLKAGLVDFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFK 1027
Query 196 IKELFP--TGKQLEPL---------VAPLADGKVAVGQDDLTVVLNEEGICTQ-KCALNW 243
++EL K L + + P+ + A + L LN++G + K +W
Sbjct 1028 MRELLNLHDNKVLANMYKETFKVVSMFPIKNSTFACFPE-LCFFLNKQGKREETKGCFHW 1086
Query 244 TDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIY 296
P PYI+A+ ++EIR E LV+ + + R + S I+Y
Sbjct 1087 EGEPEQFACSYPYIVAINSNFIEIRHIENGELVRCVLGNKIRMLKSYAKKILY 1139
>sp|Q6DT37|MRCKG_HUMAN Serine/threonine-protein kinase MRCK gamma
OS=Homo sapiens OX=9606 GN=CDC42BPG PE=1 SV=2
Length=1551
Score = 101 bits (250), Expect = 3e-20, Method: Composition-based stats.
Identities = 45/271 (17%), Positives = 95/271 (35%), Gaps = 25/271 (9%)
Query 75 KKIQQIHVVSQFKILVSLLEN--NIYVHDLLTFQQITTVSKAKGASLFTCDLQHTET--G 130
+++QQ+ + +LV L ++ + L + I + AK C + +
Sbjct 1131 RRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEV-AGAKIPESRGCQVLAAGSILQ 1189
Query 131 EEVLRMCVAVKKKLQLYFWKDRE--FHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLI 188
+CVAVK+++ Y + + P +S+ + +CVG + L
Sbjct 1190 ARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALY 1249
Query 189 RVDGKGSIKEL----FPTGKQLEPLVAPLADGKVAVGQDDL---------TVVLNEEGIC 235
+ + + L P ++L P L + AV + ++ G
Sbjct 1250 PLLNEAAPLALGAGLVP--EELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRK 1307
Query 236 TQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNII 295
++ L W P+ + PY+ +++ VQ++ L++ R + GS +
Sbjct 1308 SRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFL 1367
Query 296 YVASNHFVWRLIPVPMAT---QIQQLLQDKQ 323
Y + L I L + +
Sbjct 1368 YGTEKVRLTYLRNQLAEKDEFDIPDLTDNSR 1398
>sp|P51862|ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=ROM2
PE=1 SV=1
Length=1356
Score = 96.5 bits (238), Expect = 7e-19, Method: Composition-based stats.
Identities = 46/311 (15%), Positives = 109/311 (35%), Gaps = 39/311 (13%)
Query 17 QIDCLAAW--EEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFS 74
+I+ + + LL+ T G L + I++ S F ++ +N
Sbjct 1036 KINSVTSCDGGRKLLIATNSG-LYMSNIKRQ----QNKDHRHKSSAFFSTPIQLVQRN-- 1088
Query 75 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQ------QITTVSKAKGASLFTCDLQHTE 128
I QI V+ +FK ++ L++ +Y L + + + + +
Sbjct 1089 -NITQIAVLEEFKSIILLIDKKLYSCPLSLIEAEGNGTSFFKKHHKELINHVSFFAEGDC 1147
Query 129 TGEEVLRMCVAVKKKLQLYFW--------------KDREFHELQGDFSVPDVPKSMAWCE 174
G+ ++ + ++ + + + + P S+++ +
Sbjct 1148 NGKRLIVTAHSSSHSIKYFEHEHPLLAEKNGSGSGNKKSLKKKITEVIFDSEPVSISFLK 1207
Query 175 NSICVGFKRDYYLIRVDGKGSIKELFPTGKQLE--------PLVAPLADGKVAVGQDDLT 226
++C+G K+ + ++ + L P LE P+ + +
Sbjct 1208 ANLCIGCKKGFQIVSISQNAHESLLDPADTSLEFALRDTLKPMAIYRVGNMFLLCYTEFA 1267
Query 227 VVLNEEG-ICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
+N +G + ++W P PYI+A ++EIR E L++ + + R
Sbjct 1268 FFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIETGELIRCVLADKIR 1327
Query 286 FITSGGSNIIY 296
+ + I+Y
Sbjct 1328 LLQTSTQEILY 1338
>sp|Q80UW5|MRCKG_MOUSE Serine/threonine-protein kinase MRCK gamma
OS=Mus musculus OX=10090 GN=Cdc42bpg PE=1 SV=2
Length=1551
Score = 94.2 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 48/298 (16%), Positives = 106/298 (36%), Gaps = 26/298 (9%)
Query 75 KKIQQIHVVSQFKILVSLLEN--NIYVHDLLTFQQITTVSKAKGASLFTCD--LQHTETG 130
+++Q++ V S +L L ++ + L + V+ AK C +
Sbjct 1130 RRVQRLAVSSAAGLLAVLCGRGPSVRLFALDELES-AEVAGAKIPESRGCQALVAGRILQ 1188
Query 131 EEVLRMCVAVKKKLQLYFWKDRE--FHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLI 188
+CVAVK+++ Y + + P +S+ + +CVG + L
Sbjct 1189 ARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALY 1248
Query 189 RVD--------GKGSIKELFPTGKQ---LEPLVAPLADGKVAVGQDDLTVVLNEEGICTQ 237
+ G G + E P + L+ ++ + V ++ G ++
Sbjct 1249 PLLNEAAPLALGTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDSAGRKSR 1308
Query 238 KCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYV 297
L W P + PY+ +++ VQ++ L++ R + ++
Sbjct 1309 SHELLWPAAPTGWGYTAPYLTVFSENALDVFDVRRAEWVQTVPLKKVRPLNP-EGSLFLY 1367
Query 298 ASNHFVWRLIPVPMATQ----IQQLLQDKQFELALQLAEMK---DDSDSEKQQQIHHI 348
+ + P+A + I L + + +L ++ + SD +QQQ +
Sbjct 1368 GTEKVRLTYLRNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREM 1425
>sp|Q9Y7U6|RGF1_SCHPO Rho1 guanine nucleotide exchange factor
1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=rgf1 PE=1 SV=1
Length=1334
Score = 90.3 bits (222), Expect = 5e-17, Method: Composition-based stats.
Identities = 39/219 (18%), Positives = 84/219 (38%), Gaps = 35/219 (16%)
Query 87 KILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQL 146
K+LV +++++ + F+ +T SK + ++KK
Sbjct 1099 KVLVCAVKSSVLSATIKVFEPVTNYSKTRNMP--------------------SLKK---- 1134
Query 147 YFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQL 206
+ +++ + + +P S+ + +N +CVG R + ++ +D + L P L
Sbjct 1135 FLTVNQDPLRIVKELYIPTESTSVHFLKNKLCVGCTRGFEVVSLDNLETQSLLDPADTSL 1194
Query 207 EPL----------VAPLADGKVAVGQDDLTVVLNEEGICTQ-KCALNWTDIPVAMEHQPP 255
E + + + G+ + +N +G ++ + W P P
Sbjct 1195 EFVEKKENVKPIAIYRMNGGEFLLCYSQFAFYVNRDGWRSRPTWFVVWEGSPQNFALSYP 1254
Query 256 YIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNI 294
YI+A P ++EIR E L+ I + R + G +
Sbjct 1255 YILAFEPTFIEIRHVETSELIHVISGRNIRLLADGRGKL 1293
>sp|E7F590|VPS41_DANRE Vacuolar protein sorting-associated protein
41 homolog OS=Danio rerio OX=7955 GN=vps41 PE=1 SV=1
Length=854
Score = 89.5 bits (220), Expect = 6e-17, Method: Composition-based stats.
Identities = 104/629 (17%), Positives = 201/629 (32%), Gaps = 142/629 (23%)
Query 260 VLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLL 319
+ + +R F+ + R S G ++ Y+ S + I LL
Sbjct 317 ISSDALTVRNFQENQC------RDYRLEHSEGESLFYIISPKDIVVAKERDQDDHIDWLL 370
Query 320 QDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFN--LFCQKRFDESMQVFAKLGTDPT 377
+ K++E AL AE+ + Q K A+ L + +D + +
Sbjct 371 EKKKYEEALMAAEISFKNIKRHDVQ----KIGMAYINHLVEKGDYDTAAR---------- 416
Query 378 HVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQ 437
K L + +++ + +
Sbjct 417 ---------------------------------KCQKVLGKNMDLWENEVYRFKTIGQLK 443
Query 438 SSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLR-----LENNHCHIEES 492
+ + L G +L I +L +L T+ A L+R L NN ++
Sbjct 444 AISQYLPRGD------LRLRPAIYEMILHDFLKTDYEGFATLIREWPGELYNNMAIVQAV 497
Query 493 EHVLKK----AHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGT 548
LKK + + L LY +++AL++ + K L ++
Sbjct 498 NEHLKKDPTNSILLTTLAELYTYDQRYDRALEIYLRLRHKDVYQLIHKHNLFSSIKDK-- 555
Query 549 ENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHII 608
V ++ E + + ++ + + D+V+ L + + L + YL +
Sbjct 556 ---------IVLLMDFDKEKAVDMLLDNEDK---ISMDKVVEELKDRPELLHV-YLHKLF 602
Query 609 HVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFL 668
G ++H I LY E R LL FL
Sbjct 603 KRDHHKGQKYHERQISLYAE------------------------------FDRPNLLPFL 632
Query 669 EISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYD 728
S + + + +EE LL RMG +AL + + L + A E+ + D
Sbjct 633 RESMHCPLEKALEICQQRHFVEETVFLLSRMGNCRRALQMIMEELANVDKAIEFAKEQDD 692
Query 729 RNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKAL 788
R +++ L+ + P +L + +D +
Sbjct 693 R------ELWEDLISYSIDKPPFITG-------------------LLNNIGTHVDPILLI 727
Query 789 NLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITE 848
+ + +I ++R L K+L + + + K +L A+ L + + Q+ + E
Sbjct 728 HRIKEGMEIPNLRDSLVKILHDYNLQILLREGCKKILVADSLSLLQRMHRTQKKGVRVDE 787
Query 849 EKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
E +C C I S A+ VV + C
Sbjct 788 ENICESCHTPILPSDTAQ--AFGVVVFHC 814
>sp|P23643|VPS3_YEAST Vacuolar protein sorting-associated protein
3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
OX=559292 GN=VPS3 PE=1 SV=1
Length=1011
Score = 88.4 bits (217), Expect = 2e-16, Method: Composition-based stats.
Identities = 156/919 (17%), Positives = 308/919 (34%), Gaps = 136/919 (15%)
Query 5 FEPVPILEKLPLQI--DCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRF 62
F +L+ +P + C A+E + +GT G LL Y E N
Sbjct 131 FTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHY-------------FELERGNYM 177
Query 63 EVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTC 122
V+ K + + KI +I ++ + + + L +N + + L F ++ KG S
Sbjct 178 LVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVI 237
Query 123 DLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFK 182
+ + A +L + L F+ + K+ A E ++ V
Sbjct 238 CNFSRSSKAYRIYAFHAEGVRLLKI---SADSLVLTKAFNFKLIDKACA-HEETLMVSKL 293
Query 183 RDYYLIRVDGKGSIK--ELFPTGKQLEPLVAPLADG-KVAVGQDD-------LTVVLNEE 232
Y LI + I + T + LEP++ + + V + +V+N
Sbjct 294 NSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHH 353
Query 233 GICTQKCALNWTDIPVAMEHQPPYIIAVLP-RYVEIRTFEP---RLLVQSIELQRPRFIT 288
G K + + P + + PYIIA + V+I + P L+QSI
Sbjct 354 GDII-KGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKI 412
Query 289 SGGSNIIYVASNHFVW--------RLIPVP-----MATQIQQLLQDKQFELALQL----- 330
S N+ +N + RL P+ + ++ ++ +E L
Sbjct 413 SKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNN 472
Query 331 -----------------AEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFA--- 370
E + + E Q + K+L F + ++ S+ +F
Sbjct 473 LGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHI-EAKYLMSLLLFLMTL 531
Query 371 ----------------KLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHL 414
D + ++ + ++ N + L +L
Sbjct 532 HYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCE 591
Query 415 ALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVA 474
++ L +++L KK + +++ ID TL K L
Sbjct 592 NILKMLLMMKNELKKK-------------NKTGLLTNDFDDIMKTIDITLFKLRLEKKET 638
Query 475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLK 534
+ + E+ I E K + LI +Y++KG + KAL +L + +
Sbjct 639 ITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSF 698
Query 535 GHERTV----QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLG 590
E Y++ ++L L + E +K + L + + ++ L
Sbjct 699 IEENLKKLPEDYIKERIADDLLLTLKQGD---ENTEECAIKKVLKILD-MACINKNDFLN 754
Query 591 FLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEY-----LLSFPAGK 645
+ L + ++E + S+F L Y K++ ++ + L F
Sbjct 755 KIPAEETSLKVSFIEQLGVQNS-NDSKF---LFNYYLAKLREIINQSNIWSILGDFIKEY 810
Query 646 TPVPAGEEEGELGEYRQKLLMFLEI---SSYYDPGRLICDFP--FDGLLEERALLLGRM- 699
A ++ KL L+ S YY+ + D + + ++
Sbjct 811 KDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKID 870
Query 700 GKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKL 759
+H L + + L + +EE K Y D + Y+ ++ + L
Sbjct 871 KEHILTLLFFPNELTNWVSSEELL-KIYLSFNDFRS------VEKYIGKQNLVAVMKQYL 923
Query 760 ELLEPKANLQAALQVLELHHSKLDTT----KALNLLPANTQINDIRIFLEKVLEENAQKK 815
++ +++ +L+ + LD T K L +P+ + I L KVL + +KK
Sbjct 924 DISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKK 983
Query 816 RFNQVLKNLLHAEFLRVQE 834
+ + K LL + E
Sbjct 984 EESNLRKCLLKNQISISDE 1002
>sp|Q9UTR5|RGF2_SCHPO Rho1 guanine nucleotide exchange factor
2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=rgf2 PE=1 SV=1
Length=1158
Score = 87.6 bits (215), Expect = 3e-16, Method: Composition-based stats.
Identities = 34/168 (20%), Positives = 65/168 (39%), Gaps = 12/168 (7%)
Query 156 ELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPL-- 213
++ + +P S+ + + +CVG + + +I ++ L P L
Sbjct 972 KIFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQSLLNPADTSFRFLEKREDI 1031
Query 214 -------ADGKVAVGQDDLTVVLNEEGICTQKC-ALNWTDIPVAMEHQPPYIIAVLPRYV 265
G+ + D +N G +++ +NW P PYI+A P ++
Sbjct 1032 RPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALCYPYILAFEPDFI 1091
Query 266 EIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMAT 313
EIR E LVQ I Q + +T G + ++ P+P ++
Sbjct 1092 EIRNAETAELVQIIMGQNIKLLTDGRG--LISEGGEILYSTEPIPFSS 1137
>sp|Q5KU39|VPS41_MOUSE Vacuolar protein sorting-associated protein
41 homolog OS=Mus musculus OX=10090 GN=Vps41 PE=1 SV=1
Length=853
Score = 86.8 bits (213), Expect = 5e-16, Method: Composition-based stats.
Identities = 110/627 (18%), Positives = 202/627 (32%), Gaps = 138/627 (22%)
Query 260 VLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLL 319
+ + +R F+ + S G ++ YV S V I LL
Sbjct 316 ISSDALTVRGFQENEC------RDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLL 369
Query 320 QDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHV 379
+ K++E AL AE+ + K+ +I I Y +L + +D + +
Sbjct 370 EKKKYEEALMAAEISQRNI--KRHKILDIGLAYVNHLVERGEYDMAAR------------ 415
Query 380 MGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSS 439
K L + ++ K ++
Sbjct 416 -------------------------------KCQKILGKNASLWEYEVYKFKEIGQLKAI 444
Query 440 TSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLR-----LENNHCHIEESEH 494
+ L G P +K +I +L +L ++ A L+R L NN ++
Sbjct 445 SPYLPRGDPVLKP------LIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRD 498
Query 495 VLKKAHK----YSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTEN 550
LKK + L LY + AL++ + K L ++
Sbjct 499 HLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDK---- 554
Query 551 LHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHV 610
V ++ E + + ++ + + +V+ L + L YL +
Sbjct 555 -------IVLLMDFDSEKAVDMLLDNEDK---ISIKKVVEELEDR-PELQHVYLHKLFKR 603
Query 611 WEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEI 670
G R+H I LY E R LL FL
Sbjct 604 DHHKGQRYHEKQISLYAE------------------------------YDRPNLLPFLRD 633
Query 671 SSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRN 730
S++ + + +EE LL RMG AL + + L D A E+ +
Sbjct 634 STHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEF--AKEQDD 691
Query 731 KDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNL 790
+ +D+ +L PP I +L + +D ++
Sbjct 692 GELWEDL---ILYSIDKPPFITG--------------------LLNNIGTHVDPILLIHR 728
Query 791 LPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEK 850
+ +I ++R L K+L++ + + K +L A+ L + ++ Q ++ EE
Sbjct 729 IKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEEN 788
Query 851 VCMVCKKKIGNSAFARYPNGVVVHYFC 877
+C C I + A+ P VVV + C
Sbjct 789 ICESCLSPILPTDAAK-PFSVVV-FHC 813
>sp|P49754|VPS41_HUMAN Vacuolar protein sorting-associated protein
41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3
Length=854
Score = 85.3 bits (209), Expect = 1e-15, Method: Composition-based stats.
Identities = 110/627 (18%), Positives = 201/627 (32%), Gaps = 138/627 (22%)
Query 260 VLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLL 319
+ + +R F+ + S G ++ Y+ S V I LL
Sbjct 317 ISSDALTVRGFQENEC------RDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLL 370
Query 320 QDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHV 379
+ K++E AL AE+ + K+ +I I Y +L + +D + +
Sbjct 371 EKKKYEEALMAAEISQKNI--KRHKILDIGLAYINHLVERGDYDIAAR------------ 416
Query 380 MGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSS 439
K L ++ K ++
Sbjct 417 -------------------------------KCQKILGKNAALWEYEVYKFKEIGQLKAI 445
Query 440 TSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLR-----LENNHCHIEESEH 494
+ L G P +K +I +L +L ++ A L+R L NN ++
Sbjct 446 SPYLPRGDPVLKP------LIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRD 499
Query 495 VLKKAHK----YSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTEN 550
LKK + L LY + AL++ + K L ++
Sbjct 500 HLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDK---- 555
Query 551 LHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHV 610
V ++ E + + ++ + + +V+ L + L YL +
Sbjct 556 -------IVLLMDFDSEKAVDMLLDNEDK---ISIKKVVEELEDR-PELQHVYLHKLFKR 604
Query 611 WEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEI 670
G R+H I LY E R LL FL
Sbjct 605 DHHKGQRYHEKQISLYAE------------------------------YDRPNLLPFLRD 634
Query 671 SSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRN 730
S++ + + +EE LL RMG AL + + L D A E+ +
Sbjct 635 STHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEF--AKEQDD 692
Query 731 KDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNL 790
+ +D+ +L PP I +L + +D ++
Sbjct 693 GELWEDL---ILYSIDKPPFITG--------------------LLNNIGTHVDPILLIHR 729
Query 791 LPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEK 850
+ +I ++R L K+L++ + + K +L A+ L + ++ Q ++ EE
Sbjct 730 IKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEEN 789
Query 851 VCMVCKKKIGNSAFARYPNGVVVHYFC 877
+C C I S A+ P VVV + C
Sbjct 790 ICESCLSPILPSDAAK-PFSVVV-FHC 814
>sp|Q19954|VPS41_CAEEL Vacuolar protein sorting-associated protein
41 homolog OS=Caenorhabditis elegans OX=6239 GN=vps-41
PE=3 SV=4
Length=901
Score = 76.0 bits (185), Expect = 9e-13, Method: Composition-based stats.
Identities = 72/408 (18%), Positives = 141/408 (35%), Gaps = 86/408 (21%)
Query 480 LRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539
+ N ++E+E VL L LY + +E AL++L+ + +
Sbjct 544 ISKSGNLADVDETERVLMD-----ALAHLYLYERKYESALKILMSCQDFQIFNVIDKHQL 598
Query 540 VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGL 599
++ TE +++ E L++ ++ VE V+ + K L
Sbjct 599 FDLVKDQITELMNI-----------NSERALRLLLDNADSVE---PSFVMEKIGRQPK-L 643
Query 600 AIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGE 659
+ YL ++ E G+ F + +QLY E
Sbjct 644 QLAYLTKLMSRNE--GTEFADKAVQLYAE------------------------------Y 671
Query 660 YRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMA 719
++KLL FL ++ Y+ + G +EE LL + G H A+ + V ++
Sbjct 672 DQKKLLPFLRKNANYNVNKARKLCSDKGYIEETIYLLAKSGNHYDAVKMMVREYRNMEKV 731
Query 720 EEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHH 779
+YC + D+++ LL + + E A+ Q++
Sbjct 732 IDYCKD------QNDPDLWIHLLGV----------------VAEFPAHFS---QLIIEAS 766
Query 780 SKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILH 839
+ LD ++ LP ++ I ++ L+K+L + Q + + + + I
Sbjct 767 NCLDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISA 826
Query 840 QQVKCIITEEKVCMVCKKKIGN---------SAFARYPNGVVVHYFCS 878
+ C +C + I N S + G + H CS
Sbjct 827 ADESVSVNIVSRCSLCAQIIINSNQETTKKFSDIKVFKCGHIFHLACS 874
>sp|O01583|MRCK_CAEEL Serine/threonine-protein kinase mrck-1 OS=Caenorhabditis
elegans OX=6239 GN=mrck-1 PE=1 SV=3
Length=1592
Score = 75.3 bits (183), Expect = 2e-12, Method: Composition-based stats.
Identities = 37/233 (16%), Positives = 79/233 (34%), Gaps = 33/233 (14%)
Query 114 AKGASLFTCDLQHTET---GEEVLRMCVAVKKKLQLYFWKDREF-HELQGDFSVPDVPKS 169
K C L T G VA KK + ++ E H+ D ++P P+S
Sbjct 1268 IKVNDTKGCHLLAVGTNNPGGRAGFFAVAFKKSVTIFQIDRSEKRHKKWKDLAMPGTPQS 1327
Query 170 MAWCENSICVGFKRDY--------------------------YLIRVDGKGSIKELFPTG 203
+A + VGF + L+ ++ ++ L
Sbjct 1328 IAIFNGRLYVGFSHSFRSWSLVGVDSSPVGSGDASGAVLQHISLVNMEDTS-LQFLNQQT 1386
Query 204 KQLEPLVA--PLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVL 261
L+ P + + + + + + +NE G ++ + + + PY+
Sbjct 1387 SYEAKLIVNVPGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFS 1446
Query 262 PRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQ 314
V+I VQ+I L+ + ++ G + ++ ++ L+ + Q
Sbjct 1447 ENEVDIFNVTLAEWVQTINLRSAKPLSGDGILSTCLCNDSPIFVLLQNVLQDQ 1499
>sp|P93231|VPS41_SOLLC Vacuolar protein sorting-associated protein
41 homolog OS=Solanum lycopersicum OX=4081 GN=VPS41 PE=2
SV=1
Length=960
Score = 73.7 bits (179), Expect = 5e-12, Method: Composition-based stats.
Identities = 97/572 (17%), Positives = 182/572 (32%), Gaps = 126/572 (22%)
Query 288 TSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHH 347
+G + Y+ S V P I LLQ E AL+ E +
Sbjct 375 AAGDEPLYYIVSPKDVVIAKPRDAEDHINWLLQHGWHEKALEAVEANQGQSEL----LDE 430
Query 348 IKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGA 407
+ + Y +L ++++ E+ L P LL
Sbjct 431 VGSRYLDHLIVERKYAEAA--------------SLCPKLLRGSAS----------AWERW 466
Query 408 ELEKAHLALIDYLTQKRSQLVKKLNDSDHQSS-----TSPLMEGTPTIKSKKKLLQIIDT 462
AHL + L +L D+ ++ + T+P K +I T
Sbjct 467 VFHFAHLRQLPVLVPYIPTENPRLRDTAYEVALVALATNPSFHKDLLSTVKSWPPRIYST 526
Query 463 TLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVL 522
T V + + N + + LK+ L LY G H+KA +
Sbjct 527 T-----------PVFSAIEPQINTSSMTDP---LKE-----ALAELYVIDGQHDKAFALY 567
Query 523 VDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVES 582
D K ++ + + + +V +L + + +
Sbjct 568 ADLMKPDLFDFIEKHNLHDAVREKVLQLMMIDCKRAVLLL--------------IQQRDL 613
Query 583 LPRDRVLGFLIENFKGLAIPYLEHI-----IHVWEETGSRFHNCLIQLYCEKVQGLMKEY 637
+P V+ LI Y H+ V G +H+ ++LY
Sbjct 614 IPPSEVVSQLIAARDKCDYRYFLHLYLHSLFEVNLHAGKDYHDMQVELY----------- 662
Query 638 LLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLG 697
A P + LL FL S +Y + LL+E+ +LG
Sbjct 663 -----ADYDP--------------KMLLTFLRSSQHYTLEKAYEICVKKDLLKEQVFILG 703
Query 698 RMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPI 757
RMG +QAL + ++ L D A E+ ++ +++ L++ P + +
Sbjct 704 RMGNAKQALAVIINRLGDIEEAIEFV--SMQQDD----ELWEELIQQSFHKPEMVGV--- 754
Query 758 KLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRF 817
+LE LD +N+LP + +I +R L K++ + +
Sbjct 755 ----------------LLEHTVGNLDPLYIVNMLPNDLEIPRLRDRLVKIVTDYRTETSL 798
Query 818 NQVLKNLLHAEFLRVQEERILHQQVKCIITEE 849
++L A+ + + + + +++E
Sbjct 799 RHGCNDILKADCVNLLVKYYKEAKRGVCLSDE 830
>sp|A5PF44|GARL3_DANRE GTPase-activating Rap/Ran-GAP domain-like
protein 3 OS=Danio rerio OX=7955 GN=garnl3 PE=3 SV=1
Length=1015
Score = 71.4 bits (173), Expect = 3e-11, Method: Composition-based stats.
Identities = 62/356 (17%), Positives = 113/356 (32%), Gaps = 93/356 (26%)
Query 15 PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFS 74
P I C +W + LLV T ++L D + +T
Sbjct 498 PYDIVCGDSWGQSLLVATDSAGVMLL--------EDSPTLPPVQVFDKTLT--------- 540
Query 75 KKIQQIHVVSQFKILVSLLEN----NIYVHDLLTFQQ---------------ITTVSKAK 115
++Q+HV+ +L++ + +YV+ L T +Q + K K
Sbjct 541 --VKQMHVLEPQDLLIARADKGKDARLYVYRLSTLKQGIEERQLVRTKCDSRENKLEKTK 598
Query 116 GASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFH-------------------E 156
G L++ + H LR+ A++ KL L K +
Sbjct 599 GCHLYSINTHHGVE----LRIVAAIRNKLLLITRKQSRLECVSSIATVTGSTDSPVEEFQ 654
Query 157 LQGDFSVPDVPKSMAWCE-------NSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPL 209
+ + D P MA + + ICV ++ + LI + G L
Sbjct 655 YIREICLCDSPVVMALVDGPTGENDHMICVAYRHQFDLIN-ESTGDAYRLHHVDSNRVNF 713
Query 210 VAPL-----ADGKVAVGQDDLTVV--------LNEEGIC-TQKCALNWTDIPVAMEHQPP 255
VA + + + + +++ V T +W +P A P
Sbjct 714 VAAIDVYEDGEAGLLLCYNNICVYKKVCPFNGATPMIQPNTSDFHFSWNQMPNATVCAFP 773
Query 256 YIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM 311
YI+A +EIR LV + + + AS ++ + P+
Sbjct 774 YILAFTTDSIEIRLVVNGNLVYTAVVPELQLT----------ASRSDIYFISSAPI 819
>sp|Q9W1B0|GEK_DROME Serine/threonine-protein kinase Genghis Khan
OS=Drosophila melanogaster OX=7227 GN=gek PE=1 SV=1
Length=1637
Score = 69.5 bits (168), Expect = 1e-10, Method: Composition-based stats.
Identities = 38/265 (14%), Positives = 96/265 (36%), Gaps = 28/265 (11%)
Query 72 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITT-VSKAKGASLFTCDLQHTETG 130
SKKI Q+ + + +ILV L + L + V K C T
Sbjct 1239 GESKKILQLWYIEEEQILVILCGKQRNLRLLPIRALEASDVEWIKVVESKNCISACTGII 1298
Query 131 EE----VLRMCVAVKK-----KLQLYFW-KDREFHELQGDFSVPDVPKSMAWCENS-ICV 179
V +A+K+ ++ +Y + R H+ +F++ + + + + + V
Sbjct 1299 RRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRHQKTCEFTIGYMAQHLQILSDMRLVV 1358
Query 180 GFKRDYYLIRVDGKGSIKELF-PTGKQLEPL-------------VAPLAD--GKVAVGQD 223
+ + + G+ + L P + L + P G+ +
Sbjct 1359 AHQSGFTAYFLRGEATAMSLVHPENQLCAFLNYSGVDAVRVIEILCPSGGNFGEYLLVFQ 1418
Query 224 DLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQR 283
L + ++ +G ++ + + P + +++ +++I + VQSI L++
Sbjct 1419 TLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEWVQSIGLKQ 1478
Query 284 PRFITSGGSNIIYVASNHFVWRLIP 308
+ + G+ ++ ++ + +
Sbjct 1479 SLPLNNLGNVVLSSVNDTPLIVYLS 1503
>sp|P59015|VPS18_DANRE Vacuolar protein sorting-associated protein
18 homolog OS=Danio rerio OX=7955 GN=vps18 PE=2 SV=2
Length=974
Score = 68.3 bits (165), Expect = 3e-10, Method: Composition-based stats.
Identities = 90/645 (14%), Positives = 205/645 (32%), Gaps = 105/645 (16%)
Query 247 PVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRP-----RFITSGGSNIIYVASNH 301
P+++ + + +LP V +V + I + ++++ +
Sbjct 325 PISIVLTQFHFLLLLPDRVRGICTLNGQVVHEDVFPEKFGTLQKMIKDPITGLVWIYTEK 384
Query 302 FVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKR 361
V+R A + Q+ + LA+ E + A + F KR
Sbjct 385 AVFRYHIQKEARDVWQMYMNMN---KFDLAKEYCKDRPECLDMVL---AKEAEHCFQNKR 438
Query 362 FDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLT 421
+ ES + +A + + + KQ + + L+ + I L
Sbjct 439 YLESAKCYALTQNYFEEIALKFIE------AKQEEALKEFLIKKLVNLKPSEKTQITLLV 492
Query 422 QKRSQL--VKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPL 479
++L + + +E ++ K + D C+ + N + + L
Sbjct 493 TWLTELYLNRLGQLEADEGKQHLFLETREEFRTFLKSPKHKD-----CF-YNNRSTIYDL 546
Query 480 LRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539
L H ++ + Y +I Y + + AL VL SK + L
Sbjct 547 LAS---HGDVDNMVYFSVIMQDYERVISHYCQHDDYSAALDVL---SKHCDDKLF----- 595
Query 540 VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFK-- 597
+ +S +++ P+ + + L ++ L+ +
Sbjct 596 ---------------YKFSPVLMQHIPKKVVDAWI---QMGNRLDPKNLIPALVNYSQMG 637
Query 598 -----GLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGE 652
I Y+E ++ + HN L+ LY + + YL + +
Sbjct 638 SMQQINETIRYMEFCVYELDVKEEAIHNYLLSLYAKHKPDALLWYLEQAGTHVSDI---- 693
Query 653 EEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHI 712
+YD + G L+ L+ M +E+A+ + + +
Sbjct 694 --------------------HYDLKYALRLCSEHGYLQACVLVYKIMELYEEAVDLALKV 733
Query 713 LKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAAL 772
D +A+ C + +++ K ++L + +++ + +++ A+
Sbjct 734 --DVDLAKS-CADLPEDDEELRKKLWLKI----------------ARHVVQEEKDVKKAM 774
Query 773 QVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRV 832
L + L L P I+ + + LEE + + R+
Sbjct 775 NCLSS-CNLLKIEDILPFFPDFVTIDHFKEAICSSLEEYNKHIEELKQEMEEATESAKRI 833
Query 833 QEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
+E+ + ++ ++ C C + N F + G + HY C
Sbjct 834 REDIQEMRNKYGVVESQEKCATCDFPLLNRPFYLFLCGHMFHYDC 878
>sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus
OX=10090 GN=Mink1 PE=1 SV=3
Length=1308
Score = 68.0 bits (164), Expect = 3e-10, Method: Composition-based stats.
Identities = 61/329 (19%), Positives = 123/329 (37%), Gaps = 54/329 (16%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL R + V +
Sbjct 992 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIG------------------- 1032
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQI-----TTVSKAKGASLFT--- 121
++ QQ+ V+ +L+++ N + V+ L + V K +G +
Sbjct 1033 --RRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDME 1090
Query 122 -CDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHEL--QGDFS-VPDVPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ F+ +P P +
Sbjct 1091 GCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1150
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTGKQLEP-----LVAPLADG-KVAVGQDDLT 226
+ G ++ + VD S P Q + + P DG ++ + +D
Sbjct 1151 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEG 1210
Query 227 VVLNEEGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G + L W ++P ++ + I+ + +EIR+ E L +R +
Sbjct 1211 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1270
Query 286 FI-TSGGSN-IIYVAS-----NHFVWRLI 307
+ N ++ AS + V+ +
Sbjct 1271 RLKFLCERNDKVFFASVRSGGSSQVYFMT 1299
>sp|F1LP90|MINK1_RAT Misshapen-like kinase 1 OS=Rattus norvegicus
OX=10116 GN=Mink1 PE=1 SV=2
Length=1336
Score = 68.0 bits (164), Expect = 4e-10, Method: Composition-based stats.
Identities = 58/329 (18%), Positives = 121/329 (37%), Gaps = 54/329 (16%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL R + V +
Sbjct 1020 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIG------------------- 1060
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQI-----TTVSKAKGASLFT--- 121
++ QQ+ V+ +L+++ N + V+ L + V K +G +
Sbjct 1061 --RRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDME 1118
Query 122 -CDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHEL--QGDFS-VPDVPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ F+ +P P +
Sbjct 1119 GCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1178
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFP---TGKQLEPLVAPLADG---KVAVGQDDLT 226
+ G ++ + VD S P + + L + ++ + +D
Sbjct 1179 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEG 1238
Query 227 VVLNEEGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G + L W ++P ++ + I+ + +EIR+ E L +R +
Sbjct 1239 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1298
Query 286 FI-TSGGSN-IIYVAS-----NHFVWRLI 307
+ N ++ AS + V+ +
Sbjct 1299 RLKFLCERNDKVFFASVRSGGSSQVYFMT 1327
>sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens
OX=9606 GN=MINK1 PE=1 SV=2
Length=1332
Score = 68.0 bits (164), Expect = 4e-10, Method: Composition-based stats.
Identities = 61/329 (19%), Positives = 123/329 (37%), Gaps = 54/329 (16%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL R + V +
Sbjct 1016 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIG------------------- 1056
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQI-----TTVSKAKGASLFT--- 121
++ QQ+ V+ +L+++ N + V+ L + V K +G +
Sbjct 1057 --RRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDME 1114
Query 122 -CDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHEL--QGDFS-VPDVPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ F+ +P P +
Sbjct 1115 GCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEG 1174
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTGKQLEP-----LVAPLADG-KVAVGQDDLT 226
+ G ++ + VD S P Q + + P DG ++ + +D
Sbjct 1175 QRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEG 1234
Query 227 VVLNEEGICTQKCALNWTDIPVAMEH-QPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G + L W ++P ++ + I+ + +EIR+ E L +R +
Sbjct 1235 VYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1294
Query 286 FI-TSGGSN-IIYVAS-----NHFVWRLI 307
+ N ++ AS + V+ +
Sbjct 1295 RLKFLCERNDKVFFASVRSGGSSQVYFMT 1323
>sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase
OS=Mus musculus OX=10090 GN=Tnik PE=1 SV=2
Length=1323
Score = 66.4 bits (160), Expect = 1e-09, Method: Composition-based stats.
Identities = 65/331 (20%), Positives = 121/331 (37%), Gaps = 62/331 (19%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL S L
Sbjct 1007 KRFNSEILCAALWGVNLLVGTENGLMLL----------------DRSGQGKVYNLINR-- 1048
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQ-----ITTVSKAKG----ASLF 120
++ QQ+ V+ +LV++ N + V+ L + V K +G L
Sbjct 1049 ---RRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE 1105
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPD---VPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ S D P +
Sbjct 1106 GCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEG 1165
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTG-----KQLEPLVAPLADG-KVAVGQDDLT 226
+ G +++I VD S P+ ++ P DG ++ V +D
Sbjct 1166 QRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEG 1225
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G T+ L W ++P ++ + I+ + +EIR+ E L +R +
Sbjct 1226 VYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1285
Query 286 FIT---------------SGGSNIIYVASNH 301
+ SGGS+ ++ + +
Sbjct 1286 RLKFLCERNDKVFFASVRSGGSSQVFFMTLN 1316
>sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase
OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1
Length=1360
Score = 66.0 bits (159), Expect = 1e-09, Method: Composition-based stats.
Identities = 65/331 (20%), Positives = 121/331 (37%), Gaps = 62/331 (19%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL S L
Sbjct 1044 KRFNSEILCAALWGVNLLVGTENGLMLL----------------DRSGQGKVYNLINR-- 1085
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQ-----ITTVSKAKG----ASLF 120
++ QQ+ V+ +LV++ N + V+ L + V K +G L
Sbjct 1086 ---RRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLE 1142
Query 121 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPD---VPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ S D P +
Sbjct 1143 GCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEG 1202
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTG-----KQLEPLVAPLADG-KVAVGQDDLT 226
+ G +++I VD S P+ ++ P DG ++ V +D
Sbjct 1203 QRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEG 1262
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G T+ L W ++P ++ + I+ + +EIR+ E L +R +
Sbjct 1263 VYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1322
Query 286 FIT---------------SGGSNIIYVASNH 301
+ SGGS+ ++ + +
Sbjct 1323 RLKFLCERNDKVFFASVRSGGSSQVFFMTLN 1353
>sp|Q24314|VPS18_DROME Vacuolar protein sorting-associated protein
18 homolog OS=Drosophila melanogaster OX=7227 GN=dor PE=1
SV=3
Length=1002
Score = 65.3 bits (157), Expect = 2e-09, Method: Composition-based stats.
Identities = 99/654 (15%), Positives = 204/654 (31%), Gaps = 111/654 (17%)
Query 246 IPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR------FITSGGSNIIYVAS 299
P A + + + +V + V R + IYV +
Sbjct 352 TPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQEAFDEARVGKPLSIERDELTGSIYVYT 411
Query 300 NHFVWRLIPVPMATQIQQL-LQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFC 358
V+ L + ++ L Q+ELA A D E Q + + A F
Sbjct 412 VKTVFNLRVTREERNVWRIYLDKGQYELATAHA----AEDPEHLQLVLCQRADAA---FA 464
Query 359 QKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALID 418
+ + +A+ V + +LP +I+
Sbjct 465 DGSYQVAADYYAETDKSFEEVCLKF-MVLPD-----------------------KRPIIN 500
Query 419 YLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAP 478
Y+ ++ S++ K ++D ++ K ++ +ID L++ N+
Sbjct 501 YVKKRLSRVTTKPMETDE-------LDEDKMNIIKALVIWLIDLYLIQI----NMPDKDE 549
Query 479 LLRL--ENNHCHIEESEHVLKKAHKYSELI---ILYEKKGLHEKALQVLVDQSKKANSPL 533
R + + HVL + E + I + + + + +
Sbjct 550 EWRSSWQTEYDEFMMEAHVLSCTRQNRETVRQLIAEHADPRNMAQFAIAIGDYDEVVAQQ 609
Query 534 KGHERTVQYLQHLGTE-NLHLIFSYSVWVLRDFPEDGLKIFTEDLP--EVESLPRDRVLG 590
E + LQ L + N L + Y+ ++ P+ + EVE L ++
Sbjct 610 LKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQGSRLEVEKLVPTLIIM 669
Query 591 FLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPA 650
+ YLE I+ T HN L+ LY E L+ +YL ++
Sbjct 670 E-NREQREQTQRYLEFAIYKLNTTNDAIHNFLLHLYAEHEPKLLMKYLEIQGRDES---- 724
Query 651 GEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGR-MGKHEQALFIY 709
L Y ++ D +L + + + AL
Sbjct 725 -----------------LVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLALTF- 766
Query 710 VHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQ 769
D ++A+E + + ++L + ++ +++
Sbjct 767 -----DMKLAKE--TASRPSDSKIRRKLWLRI----------------AYHDIKGTNDVK 803
Query 770 AALQVLELHHSKLDTTKALNLLP--ANTQ-INDIRIFLEKVLEENAQKKRFNQVLKNLLH 826
AL +L + D + +LLP A+ + I++ + + L + Q+ + Q
Sbjct 804 KALNLL----KECDLLRIEDLLPFFADFEKIDNFKEAICDALRDYNQRIQELQREMAETT 859
Query 827 AEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKE 880
+ RV E +Q + + C +C+ + F + G H C ++
Sbjct 860 EQTDRVTAELQQLRQHSLTVESQDTCEICEMMLLVKPFFIFICGHKFHSDCLEK 913
>sp|Q5ZJY3|GARL3_CHICK GTPase-activating Rap/Ran-GAP domain-like
protein 3 OS=Gallus gallus OX=9031 GN=GARNL3 PE=2 SV=1
Length=917
Score = 64.1 bits (154), Expect = 5e-09, Method: Composition-based stats.
Identities = 60/332 (18%), Positives = 111/332 (33%), Gaps = 84/332 (25%)
Query 15 PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFS 74
P ++ C +W + LLV T G LL+ + F+ TL+
Sbjct 483 PHEVVCADSWGQSLLVSTDAGILLI-------------DDGQTTVQVFDKTLQ------- 522
Query 75 KKIQQIHVVSQFKILVSLLE----NNIYVHDLLTFQQ---------------ITTVSKAK 115
I+Q+HV+ L++ + + + V L + Q+ + + K
Sbjct 523 --IKQMHVLEALDYLIARTDKGKDSRLLVFRLSSVQKDIETKQVIRSKYDCRENKLERTK 580
Query 116 GASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR-----------------EFHELQ 158
G L+ + H+ LR+ VA++ KL L K E +
Sbjct 581 GCHLYAINTHHSSE----LRIVVAIRNKLLLITKKYNPCNSLTGSSLSLSESPVEEFQYI 636
Query 159 GDFSVPDVPKSMAWCE-------NSICVGFKRDYYLIRVDGKGSI-----KELFPTGKQL 206
+ + D P M + N ICV ++ + L+ + G E
Sbjct 637 REICLSDPPVVMTLVDGPTGDSDNMICVAYRHQFDLVN-ESTGESYRLHHIEANKVNFVA 695
Query 207 EPLVAPLADGKVAVGQDDLT----VVLNEEGICTQKCA-----LNWTDIPVAMEHQPPYI 257
V + + + + + V G + + +W +P A+ PYI
Sbjct 696 AIDVYEDGEAGLLLCYNYVCQYRKVYPFNGGSPLIQPSAYDFHFSWNQVPYAVVCAFPYI 755
Query 258 IAVLPRYVEIRTFEPRLLVQSIELQRPRFITS 289
+A +EIR LV + + + + S
Sbjct 756 LAFTTDSIEIRLVVNGNLVHTAVVPELQLVAS 787
>sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase
kinase kinase 4 OS=Mus musculus OX=10090 GN=Map4k4 PE=1 SV=1
Length=1233
Score = 64.1 bits (154), Expect = 5e-09, Method: Composition-based stats.
Identities = 60/329 (18%), Positives = 124/329 (38%), Gaps = 54/329 (16%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL R + V ++
Sbjct 917 KRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLIS------------------- 957
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQI-----TTVSKAKGASLFT--- 121
++ QQ+ V+ +LV++ + + V+ L + V K +G +
Sbjct 958 --RRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLE 1015
Query 122 -CDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHEL--QGDFS-VPDVPKSMAWCEN-- 175
C E + + +A+K +++Y W + +H+ F + P +
Sbjct 1016 GCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELLHKPLLVDLTVEEG 1075
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTGKQL-----EPLVAPLADG-KVAVGQDDLT 226
+ G ++ + VD PT Q ++ P DG ++ V +D
Sbjct 1076 QRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEG 1135
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G T+ L W ++P ++ + + + +EIR+ E L +R +
Sbjct 1136 VYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1195
Query 286 FIT--SGGSNIIYVAS-----NHFVWRLI 307
+ G ++ ++ +S + V+ +
Sbjct 1196 RLKFLCGRNDKVFFSSVRSGGSSQVYFMT 1224
>sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase
kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2
Length=1239
Score = 63.7 bits (153), Expect = 7e-09, Method: Composition-based stats.
Identities = 61/329 (19%), Positives = 120/329 (36%), Gaps = 54/329 (16%)
Query 12 EKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNK 71
++ +I C A W LLVGT+ G +LL S L
Sbjct 923 KRFNSEILCAALWGVNLLVGTESGLMLL----------------DRSGQGKVYPLINR-- 964
Query 72 NFSKKIQQIHVVSQFKILVSLLE--NNIYVHDLLTFQQI-----TTVSKAKGASLFT--- 121
++ QQ+ V+ +LV++ + + V+ L + V K +G +
Sbjct 965 ---RRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLE 1021
Query 122 -CDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHE-----LQGDFSVPDVPKSMAWCEN 175
C E + + +A+K +++Y W + +H+ G+ + + E
Sbjct 1022 GCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEG 1081
Query 176 ---SICVGFKRDYYLIRVDGKGSIKELFPTGKQL-----EPLVAPLADG-KVAVGQDDLT 226
+ G ++ + VD PT Q ++ P DG ++ V +D
Sbjct 1082 QRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEG 1141
Query 227 VVLNEEGICTQKCALNWTDIPVAMEHQ-PPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR 285
V +N G T+ L W ++P ++ + + + +EIR+ E L +R +
Sbjct 1142 VYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQ 1201
Query 286 FI-TSGGSN-IIYVAS-----NHFVWRLI 307
+ N ++ AS + V+ +
Sbjct 1202 RLKFLCERNDKVFFASVRSGGSSQVYFMT 1230
>sp|Q5VVW2|GARL3_HUMAN GTPase-activating Rap/Ran-GAP domain-like
protein 3 OS=Homo sapiens OX=9606 GN=GARNL3 PE=2 SV=2
Length=1013
Score = 63.0 bits (151), Expect = 1e-08, Method: Composition-based stats.
Identities = 65/344 (19%), Positives = 111/344 (32%), Gaps = 80/344 (23%)
Query 15 PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFS 74
P + C W + LLV T G L + D +P+ F+ TL
Sbjct 489 PHEAVCADPWGQALLVSTDAGVL----LVDDDLPSVPV---------FDRTL-------- 527
Query 75 KKIQQIHVVSQFKILVSLLEN----NIYVHDLLTFQQITTVSKA----------KGASLF 120
++Q+HV+ +LV + ++V L Q+ +A K
Sbjct 528 -PVKQMHVLETLDLLVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTK 586
Query 121 TCDLQHTETGEEV-LRMCVAVKKKLQLYFWKDR-------------------EFHELQGD 160
C L T LR+ VA++ KL L K E + +
Sbjct 587 GCHLYAINTHHSRELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIRE 646
Query 161 FSVPDVPKSMAWCE-------NSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPL 213
+ D P M + N ICV ++ + ++ + G L VA +
Sbjct 647 ICLSDSPMVMTLVDGPAEESDNLICVAYRHQFDVVN-ESTGEAFRLHHVEANRVNFVAAI 705
Query 214 -----ADGKVAVGQDDLTVV-----LNEEGICTQKCA----LNWTDIPVAMEHQPPYIIA 259
+ + + + + N Q A W P A+ PY++A
Sbjct 706 DVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLA 765
Query 260 VLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFV 303
+EIR LV + + + + + S + IY + V
Sbjct 766 FTTDSMEIRLVVNGNLVHTAVVPQLQLVAS--RSDIYFTATAAV 807
>sp|Q23356|MIG15_CAEEL Serine/threonine-protein kinase mig-15
OS=Caenorhabditis elegans OX=6239 GN=mig-15 PE=2 SV=3
Length=1096
Score = 63.0 bits (151), Expect = 1e-08, Method: Composition-based stats.
Identities = 49/288 (17%), Positives = 103/288 (36%), Gaps = 20/288 (7%)
Query 3 DAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRF 62
DA E +K +I C A W LL+GT G +LL R + V ++
Sbjct 766 DAPEIRKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVL 825
Query 63 EVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTC 122
E + + K+ +++ +S + + E + V +GA F
Sbjct 826 EGQNILATISGRKRRIRVYYLSWLRQKILRTEGAGSANTTEKRNGWVNVGDLQGAIHFKI 885
Query 123 DLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHE--LQGDFSVPDVPKSMA--WCENS-- 176
E + + V ++ +++Y W + +H+ F + E++
Sbjct 886 -----VRYERIKFLVVGLESSIEIYAWAPKPYHKFMSFKSFGSLSHVPLIVDLTVEDNAR 940
Query 177 --ICVGFKRDYYLIRVDGKG------SIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVV 228
+ G ++ I +D + T ++ ++ + D+ V
Sbjct 941 LKVLYGSTGGFHAIDLDSAAVYDIYTPAQSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVY 1000
Query 229 LNEEGICTQKCALNWTDIPVAMEHQPP-YIIAVLPRYVEIRTFEPRLL 275
+N G T+ L W ++P ++ + I+ + +EIR+ + L
Sbjct 1001 VNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGNKAIEIRSVDTGHL 1048
>sp|F4IDS7|VPS18_ARATH Vacuolar sorting protein 18 OS=Arabidopsis
thaliana OX=3702 GN=VPS18 PE=1 SV=1
Length=988
Score = 61.4 bits (147), Expect = 3e-08, Method: Composition-based stats.
Identities = 99/638 (16%), Positives = 208/638 (33%), Gaps = 109/638 (17%)
Query 247 PVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIEL--------QRPRFITSGGSNIIYVA 298
P +M + + ++ V++ +++ ++ + + S S ++ A
Sbjct 290 PGSMALSEYHFLLLIGNKVKVVNRISEQIIEELQFDITSDSVSRGIIGLCSDASANVFYA 349
Query 299 SNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFC 358
+ + V + + +L + A + + D ++ Q++ ++ A F
Sbjct 350 YDQNSIFQVSVIDEGRD---MWKVYLDLKVYAAALANCRDPLQRDQVYLVQAESA---FT 403
Query 359 QKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALID 418
K + + +AK+ + + + L L +D
Sbjct 404 DKEYLRAASFYAKINYVI---------------SFEEVTLKFISINEPEALRTFLLHKLD 448
Query 419 YLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAP 478
L++ + ++ + K + LL+ DT + + V
Sbjct 449 NLSKDDKCQITMISTWATELY---------LDKINRLLLED-DTAIEN--RDSEYHSVIQ 496
Query 479 LLRLENNHCHIEESEH----VLKKAHKYSELIILYEKKGLHEKALQVLVDQ--SKKANSP 532
R + C E E +L+ + EL+ K +E + + Q +KKA
Sbjct 497 EFRAFMSDCKDELDEATTVKILESYGRVEELVYFANLKEQYEIVVLHYIQQGEAKKALEV 556
Query 533 LKGHERTVQYLQHLGTENLHLIFSYS---VWVLRDFPEDGLKIFTEDLPEVESLPRDRVL 589
L+ +V+ LQ+ L ++ +Y W+ +L R++
Sbjct 557 LQKSSVSVE-LQYQFAPELIMLDAYETVESWMANK-----------------NLNPRRLI 598
Query 590 GFLIENFKGL--------AIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSF 641
++ G I YLE +H H+ L+ LY ++ L
Sbjct 599 TAMMRYSSGPHAKNETHEVIKYLEFCVHRLHNEDPGIHSLLLSLYAKQEDDGALLRFLQC 658
Query 642 PAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGK 701
GK E E +YDP + + + M
Sbjct 659 KFGKGR----ENGPEF---------------FYDPKYALRLCLKERRTRACVHIYSMMSM 699
Query 702 HEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLEL 761
HE+A+ + + I D +A K D ++D K ++L + +K E
Sbjct 700 HEEAVALALQI--DPELAMAEADKVED-DEDLRKKLWLMV-----------AKHVVKQEK 745
Query 762 LEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVL 821
+ N++ A+ L+ L L P I+D + + LE+ ++ +
Sbjct 746 GAKRENIRKAIAFLKETDGLLKIEDILPFFPDFALIDDFKEAICSSLEDYNKQIEQLKEE 805
Query 822 KNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKI 859
N ++ + Q +I ++ C VCK+KI
Sbjct 806 MNDATRGADNIRNDISALTQRYAVIDRDEECGVCKRKI 843
>sp|Q3V0G7|GARL3_MOUSE GTPase-activating Rap/Ran-GAP domain-like
protein 3 OS=Mus musculus OX=10090 GN=Garnl3 PE=1 SV=1
Length=1038
Score = 59.9 bits (143), Expect = 9e-08, Method: Composition-based stats.
Identities = 64/345 (19%), Positives = 108/345 (31%), Gaps = 81/345 (23%)
Query 15 PLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVTLEKSNKNFS 74
P + C W + LLV T G L + D +P+ F+ TL
Sbjct 512 PHEAVCADPWGQALLVSTDAGVL----LVDDDLPSVPV---------FDRTL-------- 550
Query 75 KKIQQIHVVSQFKILVSLLEN----NIYVHDLLTFQQITTVSKA----------KGASLF 120
++QIHV+ +LV + ++V L Q+ + K
Sbjct 551 -PVKQIHVLETLDLLVLRADKGKDARLFVFRLSAVQKGLDGRQTGRSRSDCRENKLEKTK 609
Query 121 TCDLQHTETGEEV-LRMCVAVKKKLQLYFWKDREFH--------------------ELQG 159
C L T LR+ VA++ KL L K +
Sbjct 610 GCHLYAINTHHSRELRIVVAIRNKLLLITRKPHNKPSGVPGVSLLSPLSESPVEEFQYIR 669
Query 160 DFSVPDVPKSMAWCE-------NSICVGFKRDYYLIRVDGKGSI-----KELFPTGKQLE 207
+ + D P MA + N ICV ++ + ++ + G E
Sbjct 670 EICLCDSPAVMALVDGPTEESDNLICVAYRHQFDVVN-ESTGEAFRLHHVEANKVNFVAA 728
Query 208 PLVAPLADGKVAVGQDDLTVV-----LNEEGICTQKCA----LNWTDIPVAMEHQPPYII 258
V + + + + + N Q A W P A+ PY++
Sbjct 729 IDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLLQPSASDFQFCWNQAPYAIVCAFPYLL 788
Query 259 AVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFV 303
A +EIR LV + + + + + S + IY + V
Sbjct 789 AFTTDSMEIRLVVNGNLVHTAVVPQLQLVAS--RSDIYFTAATTV 831
>sp|P49025|CTRO_MOUSE Citron Rho-interacting kinase OS=Mus musculus
OX=10090 GN=Cit PE=1 SV=3
Length=2055
Score = 59.9 bits (143), Expect = 1e-07, Method: Composition-based stats.
Identities = 51/327 (16%), Positives = 120/327 (37%), Gaps = 52/327 (16%)
Query 6 EPVPILEKLPLQIDC-LAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEV 64
+ + L ++C L ++ +LVGT++G L + K+ + + G F++
Sbjct 1608 SLLKLEGDDRLDMNCTLPFSDQVVLVGTEEG-LYALNVLKNSL-----THIPGIGAVFQI 1661
Query 65 TLEKSNKNFSKKIQQIHVVSQFKILVSLLE--------NNIYVHDLLTFQQITTVSKAKG 116
+ K ++++ +++ + + L++ ++ KG
Sbjct 1662 YII-------KDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDVSP-NIFEAVKG 1713
Query 117 ASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR-EFHELQGDFSVPDVPKSMAWCEN 175
LF E L +C A+ K+ + + D + ++ + + + +
Sbjct 1714 CHLFAA-----GKIENSLCICAAMPSKVVILRYNDNLSKYCIRKEIETSEPCSCIHFTNY 1768
Query 176 SICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLA----------------DGKVA 219
SI +G +Y I + + L L P V + +
Sbjct 1769 SILIG-TNKFYEIDMKQYTLDEFLDKNDHSLAPAVFASSSNSFPVSIVQANSAGQREEYL 1827
Query 220 VGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEI-----RTFEPRL 274
+ + V ++ G ++ L W+ +P+A ++ PY+ +E+ R+
Sbjct 1828 LCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSP 1887
Query 275 LVQSIELQRPRFIT-SGGSNIIYVASN 300
+E+ PR++ + S IY+AS+
Sbjct 1888 ARAYLEIPNPRYLGPAISSGAIYLASS 1914
>sp|E9PSL7|CTRO_RAT Citron rho-interacting kinase OS=Rattus norvegicus
OX=10116 GN=Cit PE=1 SV=1
Length=2055
Score = 59.5 bits (142), Expect = 2e-07, Method: Composition-based stats.
Identities = 51/327 (16%), Positives = 119/327 (36%), Gaps = 52/327 (16%)
Query 6 EPVPILEKLPLQIDC-LAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEV 64
+ + L ++C L ++ +LVGT++G L + K+ + + G F++
Sbjct 1608 SLLKLEGDDRLDMNCTLPFSDQVVLVGTEEG-LYALNVLKNSL-----THIPGIGAVFQI 1661
Query 65 TLEKSNKNFSKKIQQIHVVSQFKILVSLLE--------NNIYVHDLLTFQQITTVSKAKG 116
+ K ++++ +++ + + L++ ++ KG
Sbjct 1662 YII-------KDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDVSP-NIFEAVKG 1713
Query 117 ASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR-EFHELQGDFSVPDVPKSMAWCEN 175
LF E L +C A+ K+ + + D ++ + + + +
Sbjct 1714 CHLFAA-----GKIENSLCICAAMPSKVVILRYNDNLSKFCIRKEIETSEPCSCIHFTNY 1768
Query 176 SICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLA----------------DGKVA 219
SI +G +Y I + + L L P V + +
Sbjct 1769 SILIG-TNKFYEIDMKQYTLEEFLDKNDHSLAPAVFASSTNSFPVSIVQANSTGQREEYL 1827
Query 220 VGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEI-----RTFEPRL 274
+ + V ++ G ++ L W+ +P+A ++ PY+ +E+ R+
Sbjct 1828 LCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGTP 1887
Query 275 LVQSIELQRPRFIT-SGGSNIIYVASN 300
+E+ PR++ + S IY+AS+
Sbjct 1888 ARAYLEIPNPRYLGPAISSGAIYLASS 1914
>sp|O14578|CTRO_HUMAN Citron Rho-interacting kinase OS=Homo sapiens
OX=9606 GN=CIT PE=1 SV=2
Length=2027
Score = 57.6 bits (137), Expect = 5e-07, Method: Composition-based stats.
Identities = 49/327 (15%), Positives = 121/327 (37%), Gaps = 52/327 (16%)
Query 6 EPVPILEKLPLQIDC-LAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEV 64
+ + L ++C L ++ +LVGT++G L + K+ + + G F++
Sbjct 1582 SLLKLEGDDRLDMNCTLPFSDQVVLVGTEEG-LYALNVLKNSL-----THVPGIGAVFQI 1635
Query 65 TLEKSNKNFSKKIQQIHVVSQFKILVSLLE--------NNIYVHDLLTFQQITTVSKAKG 116
+ K ++++ +++ + + L++ ++ KG
Sbjct 1636 YII-------KDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISP-NIFEAVKG 1687
Query 117 ASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDR-EFHELQGDFSVPDVPKSMAWCEN 175
LF E L +C A+ K+ + + + + ++ + + + +
Sbjct 1688 CHLFGA-----GKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNY 1742
Query 176 SICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLA----------------DGKVA 219
SI +G +Y I + + L L P V + +
Sbjct 1743 SILIG-TNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYL 1801
Query 220 VGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQS- 278
+ + V ++ G ++ L W+ +P+A ++ PY+ +E+ + R +
Sbjct 1802 LCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTP 1861
Query 279 ----IELQRPRFIT-SGGSNIIYVASN 300
+++ PR++ + S IY+AS+
Sbjct 1862 ARAYLDIPNPRYLGPAISSGAIYLASS 1888
>sp|Q618H8|VPS41_CAEBR Vacuolar protein sorting-associated protein
41 homolog OS=Caenorhabditis briggsae OX=6238 GN=vps-41
PE=3 SV=1
Length=898
Score = 57.2 bits (136), Expect = 6e-07, Method: Composition-based stats.
Identities = 62/387 (16%), Positives = 125/387 (32%), Gaps = 82/387 (21%)
Query 504 ELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLR 563
L LY + +E AL++L+ + + ++ ++ +++
Sbjct 559 ALAHLYLYERKYESALKILMICQDFQIFNVIDKHQLFDLVKDQISDLMNI---------- 608
Query 564 DFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLI 623
E L++ ++ VE V+ + K L + YL ++ E G F + +
Sbjct 609 -NSERALRLLLDNADSVE---PSFVMAKINGQPK-LQLAYLTKLMSRNE--GIEFADKAV 661
Query 624 QLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDF 683
QLY + + + +L Y+ +
Sbjct 662 QLYADHEKKKLLPFLKKNVN------------------------------YNVTKARKLC 691
Query 684 PFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLR 743
G +EE LL + G H +A+ + V K+ YC DR+ +++ LL
Sbjct 692 SDRGFVEETIFLLAKSGNHYEAVKMMVREYKNIEKVIAYCKDQNDRD------LWIHLLE 745
Query 744 MYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIF 803
+ P+ Q++ + LD ++ LP + I ++
Sbjct 746 VVADFPTHFS-------------------QLIIEASNCLDPILIMDKLPDDVDIPNLSEA 786
Query 804 LEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSA 863
LEK+L + Q + + + +L ++ C +C + I N+
Sbjct 787 LEKLLTDFTNYVELQQCCYDSTLNDLHVLTNNLMLASDKSVSVSLMTRCSLCSQVIMNTG 846
Query 864 FARYPN----------GVVVHYFCSKE 880
P G + H CS
Sbjct 847 QDMIPRKFNDIKVFKCGHIFHLTCSAS 873
>sp|Q9P253|VPS18_HUMAN Vacuolar protein sorting-associated protein
18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2
Length=973
Score = 56.0 bits (133), Expect = 1e-06, Method: Composition-based stats.
Identities = 90/647 (14%), Positives = 204/647 (32%), Gaps = 109/647 (17%)
Query 247 PVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIEL-----QRPRFITSGGSNIIYVASNH 301
P+A+ + + +L VE +V + + ++ +
Sbjct 325 PLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLEKFGPLKHMVKDSSTGQLWAYTER 384
Query 302 FVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKR 361
V+R + + + + + LA+ + + + + F Q+R
Sbjct 385 AVFRY---HVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFR---QRR 438
Query 362 FDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLT 421
+ ES + +A + + L++ + AE + LA +
Sbjct 439 YLESARCYALTQSYFEEI--------------ALKFLEARQEEALAEFLQRKLASLKPAE 484
Query 422 QKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTL----LKCYLHTNVALVA 477
+ ++ L+ + S L + ++ + T L K +L + A +
Sbjct 485 RTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASRASIH 544
Query 478 PLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHE 537
LL + H+ +++ Y ++ + + +E+AL VL
Sbjct 545 ELLASHGDTEHMVYFAVIMQD---YERVVAYHCQHEAYEEALAVLARHR----------- 590
Query 538 RTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFK 597
+ L + +S ++R P + + E L +++ L+ +
Sbjct 591 ------------DPQLFYKFSPILIRHIPRQLVDAWIEMGSR---LDARQLIPALVNYSQ 635
Query 598 G-------LAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPA 650
G AI Y+E ++V ET HN L+ LY + YL A V
Sbjct 636 GGEVQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGRPDSLLAYLEQAGASPHRV-- 693
Query 651 GEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYV 710
+YD + G + + +E+A+ + +
Sbjct 694 ----------------------HYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLAL 731
Query 711 HILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQA 770
+ D +A++ C + +++ K ++L + +++ + ++Q
Sbjct 732 QV--DVDLAKQ-CADLPEEDEELRKKLWLKI----------------ARHVVQEEEDVQT 772
Query 771 ALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFL 830
A+ L L L P I+ + + L+ + Q A
Sbjct 773 AMACLAS-CPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQ 831
Query 831 RVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
R++ + + + + C C + N F + G + H C
Sbjct 832 RIRRDLQELRGRYGTVEPQDKCATCDFPLLNRPFYLFLCGHMFHADC 878
>sp|P27801|PEP3_YEAST Vacuolar membrane protein PEP3 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PEP3
PE=1 SV=1
Length=918
Score = 54.5 bits (129), Expect = 4e-06, Method: Composition-based stats.
Identities = 90/577 (16%), Positives = 189/577 (33%), Gaps = 88/577 (15%)
Query 318 LLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLF-CQKRFDESMQVFAKLGTDP 376
L++D +F+ AL L + +K A LF K F + Q + D
Sbjct 346 LVRDNKFDKALSLKGLTVREIE-------SVKLSKAMYLFHTAKDFHSAAQTLGSMK-DL 397
Query 377 THVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLV-------- 428
+H N L + +L + +D + K +Q+V
Sbjct 398 SH--------------FGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQVVLSSWIIWN 443
Query 429 --KKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNH 486
K+LND + + +T+ L + L
Sbjct 444 FMKQLNDIELKINTTKPASTDEDNLLNWNLNL-----------KEKSNELTKFLESHLEK 492
Query 487 CHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHL 546
E ++ K ++ +EL+I + L +DQ S L+ L
Sbjct 493 LDNETVYQIMSKQNRQNELLIFASLINDMKFLLSFWIDQGNWYES-----------LKIL 541
Query 547 GTENLH-LIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLE 605
T N H L++ YS+ +L + PE + + + ++ L ++++ +++ F
Sbjct 542 LTINNHDLVYKYSLILLLNSPEATVSTWMK----IKDLDPNKLIPTILKFFTNWQNN--- 594
Query 606 HIIHVWEETGSRFHNCLIQLYCEK-VQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKL 664
S + Y + V+ + K + + ++ +
Sbjct 595 ---SKLITNISEYPENYSLTYLKWCVREVPKMCNPIVYNSILYMMITDPRNDMILENDII 651
Query 665 LMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYV--HILKDTRMAEEY 722
+ YD + + LL R+ E A+ + + +++ D ++
Sbjct 652 KFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKNNLIDDCKVIVN- 710
Query 723 CHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKL 782
+ + K ++L + + L + Q +L + L
Sbjct 711 -DEILIEDYKLRKRLWLKIAKHLLLSMKDIDIK-------------QLIRTILNDSNEIL 756
Query 783 DTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQ--EERILHQ 840
L T I +++ L K LE + N++ +++++++ L+V+ E
Sbjct 757 TIKDLLPFFNEYTTIANLKEELIKFLEN--HNMKMNEISEDIINSKNLKVEINTEISKFN 814
Query 841 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
++ I+ K C C K + F +P G H+ C
Sbjct 815 EIYRILEPGKSCDECGKFLQIKKFIVFPCGHCFHWNC 851
>sp|Q8R307|VPS18_MOUSE Vacuolar protein sorting-associated protein
18 homolog OS=Mus musculus OX=10090 GN=Vps18 PE=1 SV=2
Length=973
Score = 54.5 bits (129), Expect = 4e-06, Method: Composition-based stats.
Identities = 92/650 (14%), Positives = 207/650 (32%), Gaps = 115/650 (18%)
Query 247 PVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGG--SNIIYVASNHFVW 304
P+A+ + + +L VE +V R F+ G +++ +S +W
Sbjct 325 PLAIVLTQFHFLLLLADRVEAVCTLTGQVV-----LRDHFLEKFGPLRHMVKDSSTGHLW 379
Query 305 RLI-----PVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQ 359
+ + + + + LA+ + + + + F Q
Sbjct 380 AYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREADFCFR---Q 436
Query 360 KRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDY 419
R+ ES + +A + + L++ + AE + LA
Sbjct 437 HRYLESARCYALTQSYFEEI--------------ALKFLEARQEEALAEFLQRKLA-GLK 481
Query 420 LTQKRSQLVKKLNDSDHQSSTSPLMEGTPTI-----KSKKKLLQIIDTTLLKCYLHTNVA 474
T++ + ++ S ++G P +++ + + K +L + A
Sbjct 482 PTERTQATLLTTWLTELYLSRLGALQGDPDALTLYRDTRECFRTFLSSPRHKEWLFASRA 541
Query 475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLK 534
+ LL + H+ +++ Y ++ + + +E+AL VL
Sbjct 542 SIHELLASHGDTEHMVYFAVIMQD---YERVVAYHCQHEAYEEALAVLARHR-------- 590
Query 535 GHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIE 594
+ L + +S ++R P + + E L +++ L+
Sbjct 591 ---------------DPQLFYKFSPILIRHIPRQLVDAWIEMGSR---LDARQLIPALVN 632
Query 595 NFKG-------LAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTP 647
+G AI Y+E ++V ET HN L+ LY + YL A
Sbjct 633 YSQGGEAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPASLLAYLEQAGASPHR 692
Query 648 VPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALF 707
V +YD + G + + +E+A+
Sbjct 693 V------------------------HYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVD 728
Query 708 IYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKAN 767
+ + + D +A++ C + +++ K ++L + +++ + +
Sbjct 729 LALQV--DVDLAKQ-CADLPEEDEELRKKLWLKI----------------ARHVVQEEED 769
Query 768 LQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHA 827
+Q A+ L L L P I+ + + L+ + Q A
Sbjct 770 VQTAMACLAS-CPLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATA 828
Query 828 EFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC 877
R++ + + + + C C + N F + G + H C
Sbjct 829 SAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHMFHADC 878
>sp|Q9P7N3|VPS41_SCHPO Vacuolar protein sorting-associated protein
41 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)
OX=284812 GN=vps41 PE=3 SV=2
Length=871
Score = 53.3 bits (126), Expect = 9e-06, Method: Composition-based stats.
Identities = 104/702 (15%), Positives = 223/702 (32%), Gaps = 159/702 (23%)
Query 174 ENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTV--VLNE 231
E+ + +G+ ++ + EL Q + + G + +G + LT+ + N
Sbjct 224 ESRLVIGWSDQIMIVSIQRSNVANELPKISLQALLEIDSIVSGVLMLGFNILTLAYIANV 283
Query 232 EGICTQKCALNWTDIPVA-MEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSG 290
E + IP +E P + + + E+ +I L +
Sbjct 284 EDFT--------SAIPSQRIEGCRPELRLIDSSFKEL-------CGDAIGLANYSRLQPS 328
Query 291 GSNIIY-VASNHFVWRLIPVPM-----ATQIQQ---LLQDKQFELALQLAEMKDDSDSEK 341
+++ +SN + + P + QI L+ + + A+ + +
Sbjct 329 DYHLLPDPSSNSHSFVISPNDIVYVRERNQIDHVKYLVSKEMYAEAIDAVKKLPEIPP-- 386
Query 342 QQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPL 401
QI + Y F+L + ++ E+ V + LY D L + +
Sbjct 387 SLQISELAKKYIFHLLGKGQYKEAGMV----------IPSLYNDNLAEWEQWVFVFAEND 436
Query 402 PVLSGAELEKAH----------LALIDYLTQKRSQLVKKLNDSDH-QSSTSPLMEGTPTI 450
+ A+ + L YL KKL++ S S + T
Sbjct 437 HLEDIADFLPTGENHLSPLVYEMILAQYLATDERTFNKKLHEWPTMLYSVSTIRNATLKK 496
Query 451 KSKKKLLQIIDTTLLKCYLHTNVALVA--PLLRLENNHCHIEESEHVLKKAHKYSELIIL 508
+ + + +L YL N+ + A L+L + C +H L + S L+
Sbjct 497 FKENQKSSTLTESLAFLYLEDNMPIDAFHLYLKLHSELCIDLILQHNLYDEARASVLL-- 554
Query 509 YEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPED 568
L ++ + K +++ VQ++
Sbjct 555 ----------LMLISSKGKSSDTKSAMSSMLVQHVH------------------------ 580
Query 569 GLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCE 628
S P V+ + + L + E + + N L++ Y +
Sbjct 581 -------------SFPPQEVIMQIHSVPQFLYEYFCEFELM--------YPNSLME-YGD 618
Query 629 KVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGL 688
+ E+ R++ FL + Y
Sbjct 619 LKLDVFAEFD----------------------RKRFFDFLVNTQCYSLDHAAQICKQYNY 656
Query 689 LEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSP 748
L+E +LGRMG +++AL + ++ L D A Y + DR +++ L+ L
Sbjct 657 LDELVYILGRMGNNKEALMLIINELLDIGRAIRYVKEQADR------ELWDDLISYSLDK 710
Query 749 PSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVL 808
P C +LE + + L+ +P T++ ++ + K+L
Sbjct 711 PEFICT-------------------LLENIGTDENARNLLSKIPPGTKLPHMKKSISKLL 751
Query 809 EENAQKKRFNQVLKNLLHAE--FLRVQEERILHQQVKCIITE 848
++ + + Q L E + ++ ++ ++ +
Sbjct 752 ADHQSQVQLYQSCYKLFKNESISMAIKYREQEQSGLEFLVKD 793
>sp|Q9Y7U5|RGF3_SCHPO Rho1 guanine nucleotide exchange factor
3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812
GN=rgf3 PE=1 SV=1
Length=1275
Score = 53.7 bits (127), Expect = 9e-06, Method: Composition-based stats.
Identities = 46/255 (18%), Positives = 82/255 (32%), Gaps = 43/255 (17%)
Query 74 SKKIQQIHVVSQFKILVSLLENNIYVHDLL-------------------------TFQQI 108
+++ Q+ VV +F IL+ L + +Y H L ++
Sbjct 976 QRRVTQLGVVEEFDILLELRDKTLYAHKLSRIIEMGLIESKIAVVIGTPHAVSFFKIGKL 1035
Query 109 TTVSKAKGASL--FTCDLQHTETGEEVLRMCVAVK---KKLQLYFWKDREFHELQGDFSV 163
+ + K F + T + + +K + KD DF V
Sbjct 1036 SEGASVKRERTLVFYKEGLGNTTTIICCEPVIGLGHNYQKTYAFKRKDVTSFRTLDDFHV 1095
Query 164 PDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPT-----------GKQLEPLVAP 212
S+ + SI + + ++R+D K ++ P+ V
Sbjct 1096 TANCHSIDCFKYSIALCHNKGIDVLRLDPKLAVGFPSPSVLNDTLFRNRINNSKPLGVFR 1155
Query 213 LAD-GKVAVGQDDLTVVLNEEGICTQKCA-LNWTDIPVAMEHQPPYIIAVLPRYVEIRTF 270
+ D A V +N EG K +W P ++ Y+IA +VEI
Sbjct 1156 IHDPSLFACCYQFGAVFVNGEGSMVNKECWFDWIGKPNSVTSCHGYLIAFNDEFVEIWNT 1215
Query 271 EPRLLVQSIELQRPR 285
R L Q I+ +
Sbjct 1216 RTRKLNQIIQGNDIK 1230
>sp|P38959|VPS41_YEAST Vacuolar protein sorting-associated protein
41 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
OX=559292 GN=VPS41 PE=1 SV=2
Length=992
Score = 52.6 bits (124), Expect = 2e-05, Method: Composition-based stats.
Identities = 50/329 (15%), Positives = 113/329 (34%), Gaps = 35/329 (11%)
Query 318 LLQDKQFELALQL---AEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLG- 373
L + FE L+ A + + S+++ + + ++ +++ K
Sbjct 640 LFSVEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENKYTKAIPHLLKAKD 699
Query 374 ---TDPTHVMGLYPDLLPT-------DYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQK 423
+ L P L Y+ ++ + + L + ++ ID L +
Sbjct 700 LRALTIIKIQNLLPQYLDQIVDIILLPYKGEISHISKLSIFE---IQTIFNKPIDLLFEN 756
Query 424 RSQL-VKKLNDSDHQSSTSPLMEG------TPTIKSKKKLLQIIDTTLLKCYLHTNVALV 476
R + V ++ + + ++ + L++ Y + +
Sbjct 757 RHTISVARIYEIFEHDCPKSFKKILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSL 816
Query 477 APLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGH 536
P L+ NN+ E K Y+ELI L+ K G +KAL +++D+ LK
Sbjct 817 LPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDE-------LKNP 869
Query 537 ERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENF 596
+ + ++++ G L + + + D P I T E + + G +
Sbjct 870 QLAIDFVKNWGDSEL---WEFMINYSLDKPNFTKAILTC-SDETSEIYLKVIRGMSDDLQ 925
Query 597 KGLAIPYLEHIIHVWEETGSRFHNCLIQL 625
++HI+ + N L+ +
Sbjct 926 IDNLQDIIKHIVQENSLSLEVRDNILVII 954
Score = 48.7 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 73/428 (17%), Positives = 145/428 (34%), Gaps = 99/428 (23%)
Query 431 LNDSDHQSSTSPLMEGTPTIKSKKKLLQII-DTTLLKCYLHTNVALVAPLLRLENNHCHI 489
+ D + + T PT SK++ I T L+ YL N
Sbjct 643 VEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENK---------------Y 687
Query 490 EESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTE 549
++ L KA L I+ + + L + L +VD L ++ + ++ L
Sbjct 688 TKAIPHLLKAKDLRALTII-KIQNLLPQYLDQIVDII------LLPYKGEISHISKLSIF 740
Query 550 NLHLIF-SYSVWVLRDFPEDGL----KIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYL 604
+ IF + + + +IF D P K L +
Sbjct 741 EIQTIFNKPIDLLFENRHTISVARIYEIFEHDCP--------------KSFKKILFCYLI 786
Query 605 EHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKL 664
+ + S + N LI+LY E RQ L
Sbjct 787 KFLDTDDSFMISPYENQLIELYSE------------------------------YDRQSL 816
Query 665 LMFLEISSYYDPGRLICDFPFD-GLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYC 723
L FL+ + Y+ I GL E L G++G+ ++AL + + LK+ ++A ++
Sbjct 817 LPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDFV 876
Query 724 HKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLD 783
G+ +++ ++ L P N A+ S++
Sbjct 877 KNW------GDSELWEFMINYSLDKP-----------------NFTKAILTCSDETSEI- 912
Query 784 TTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEE--RILHQQ 841
K + + + QI++++ ++ +++EN+ + +++ E + E +I Q
Sbjct 913 YLKVIRGMSDDLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDETKKFANEFLKIRSQG 972
Query 842 VKCIITEE 849
+ E
Sbjct 973 KLFQVDES 980
>sp|P93043|VPS41_ARATH Vacuolar protein sorting-associated protein
41 homolog OS=Arabidopsis thaliana OX=3702 GN=VPS41 PE=1
SV=3
Length=980
Score = 51.8 bits (122), Expect = 3e-05, Method: Composition-based stats.
Identities = 87/531 (16%), Positives = 167/531 (31%), Gaps = 113/531 (21%)
Query 288 TSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHH 347
+G + Y+ S V P I LLQ E AL E +
Sbjct 381 AAGDEPLYYIVSPKDVVIAKPRDAEDHINWLLQHGFHEKALAAVEASEGRTELID----- 435
Query 348 IKNLYAFN--LFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYR-KQLQYPNPLPVL 404
K + L ++++ E+ L P LL +
Sbjct 436 -KVGAGYLDHLIVERKYAEAA--------------SLCPKLLRGSASAWERWV------F 474
Query 405 SGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTL 464
A+L + L+ Y+ +L + + + + + + K + + + L
Sbjct 475 HFAQLRQ-LPVLVPYMPTDNPRLKDTVYEVALVALATNPSYHKELLSAVKSWPRSVYSAL 533
Query 465 LKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVD 524
V + + N + ++ LK+ L LY G ++KA + D
Sbjct 534 ----------TVISAIEPQLNTSSMTDA---LKE-----ALAELYVIDGQYQKAFSLYAD 575
Query 525 QSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDF-----PEDGLKIFTEDLPE 579
K + ++ + + L + + P + + +
Sbjct 576 LLKPEVFDFIEKYSLHEAIRGKVVQLMLLDCKRATVLFIQNRDLIPPSEVVPQLLKAGKN 635
Query 580 VESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLL 639
+ L + + + YL + V +TG FH+ ++LY E
Sbjct 636 PQVLKAGK-----KCDSRYYLYLYLHALFEVSHDTGKDFHDMQVELYAE----------- 679
Query 640 SFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRM 699
+ LL FL S +Y + L E+ +LGRM
Sbjct 680 -------------------YDTKMLLPFLRSSQHYKLEKAYELCVKKDFLREQVFVLGRM 720
Query 700 GKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKL 759
G +QAL + ++ L D A E+ + + D++ L++ L+ P + L
Sbjct 721 GNAKQALAVIINKLGDIEEAVEF------VSMQHDDDLWEELIKQCLNKPEMVGL----- 769
Query 760 ELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEE 810
+LE LD +N++P +I +R L K++ +
Sbjct 770 --------------LLEHTVGNLDPLYIVNMVPNGLEIPRLRDRLVKIVTD 806
>sp|P12868|PEP5_YEAST E3 ubiquitin-protein ligase PEP5 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=PEP5 PE=1 SV=2
Length=1029
Score = 50.2 bits (118), Expect = 8e-05, Method: Composition-based stats.
Identities = 75/540 (14%), Positives = 165/540 (31%), Gaps = 91/540 (17%)
Query 76 KIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEV-L 134
++ ++ + + L + + + + I+ VS ++ +C + G+ + +
Sbjct 102 RVYKLEKLPNREQLY---HSQVELKNGNNTYPISVVSI---SNDLSCIVVGFINGKIILI 155
Query 135 RMCVAVKKKLQL-YFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDG- 192
R ++ + Q ++D + F D A L G
Sbjct 156 RGDISRDRGSQQRIIYEDPSKEPITALFLNNDATACFA--------ATTSRILLFNTTGR 207
Query 193 KGSIKELFPTGKQLEPLVAPLAD---GKVAVGQDDLTVVLNEEGICTQ------------ 237
L K L + + + + G Q
Sbjct 208 NRGRPSLVLNSKNGLDLNCGSFNPATNEFICCLSNFIEFFSSSGKKHQFAFDLSLRKRIF 267
Query 238 ----------KCALNWTDIPVAMEHQPPYIIAVLPRYVEI----RTFEPRLLVQSIELQR 283
+++ P II + I V S +
Sbjct 268 CVDKDHILIVTEETGVPTTSISVNELSPTII----NRIFIIDAKNKIISLNFVVSSAIID 323
Query 284 PRFITSGGSNIIYVASNHFV-WRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQ 342
+ G NI Y+ ++ V R+ P + QI ++Q + + ALQLA+ S
Sbjct 324 IFSTSQSGKNITYLLTSEGVMHRITPKSLENQINIIIQKELYPFALQLAK----QHSLSP 379
Query 343 QQIHHIKNLYAFNLFCQKRFDESMQVFAKL--GTDPTHVMGLYPDLLPTDYRKQLQYPNP 400
+ I Y LF + E+ + + + + ++ + + P+P
Sbjct 380 LDVQEIHKKYGDYLFKKGLRKEATDQYIQCLDVVETSEIISKF---------GVKEVPDP 430
Query 401 LPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQII 460
++ L DYL ++ DH + ++ ++ +Q
Sbjct 431 ----------ESMRNLADYLWSLIKN---SISQRDHVTLLLIVLIKLKDVEGIDTFIQHF 477
Query 461 D-TTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKAL 519
D + + + +N+ + + L K + L Y + K
Sbjct 478 DRKGIWNEGVVMDDMDDVTFFYSDNDFFDL-DLILELMKESDFKRLS--YRLAKKYSKDS 534
Query 520 QVLVDQSKKANSPLKGHERTVQYLQHLG-TENLHLIFSYSVWVLRDFPEDG----LKIFT 574
++VD L + ++Y++ L E L + +YS +L + P + +++FT
Sbjct 535 LIIVDILLNL---LHNPVKAIKYIKSLPIDETLRCLVTYSKKLLEESPNETNALLIEVFT 591
>sp|Q10161|CLH_SCHPO Probable clathrin heavy chain OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=chc1
PE=1 SV=1
Length=1666
Score = 44.5 bits (103), Expect = 0.005, Method: Composition-based stats.
Identities = 70/384 (18%), Positives = 118/384 (31%), Gaps = 52/384 (14%)
Query 432 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE 491
L ++S + I D L K Y+ +N + ENN
Sbjct 845 EVERRNRLKLLLPYLESLLQSGSQDRAIYD-ALAKIYIDSNNNP--EVFLKENNFYDTLT 901
Query 492 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL 551
+K Y I YEK G + + + NS K R YL NL
Sbjct 902 VGKYCEKRDPYLA-FIAYEKGGNDTEIINLC-----NENSMFKQLAR---YLLKRSDSNL 952
Query 552 -HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENF-KGLAIPYLEHIIH 609
+ S + P I T + V+ L+E I LE I+
Sbjct 953 WSEVLQDSAY---RRPLLDQVIATAVPESSDPEAVSIVVKALMEVDLPSQLIELLEKIV- 1008
Query 610 VWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLE 669
S F +Q L+ +L + A K+ +++ +++
Sbjct 1009 ---LQPSSFSEN------ANLQNLL--FLTAIKADKS----------------RVMEYID 1041
Query 670 ISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDR 729
YD + +GL EE + KHEQA+ + V + A++Y
Sbjct 1042 KLDKYDVDEIAEIAIENGLYEEAFRIYKIHNKHEQAMKVLVEDIVSLDRAQDYAETVEQ- 1100
Query 730 NKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALN 789
+V+ L + L I L+ +P N +++ + K L
Sbjct 1101 -----PEVWSRLAKAQLDGIRIPDAIESYLKADDPS-NYSEVIELASRAGKYEELIKYLL 1154
Query 790 LLPANTQINDIRIFLEKVLEENAQ 813
+ + D+ L + Q
Sbjct 1155 MARSKMHEPDVDSALLIAYAKTNQ 1178
>sp|Q09600|VPS11_CAEEL Vacuolar protein sorting-associated protein
11 homolog OS=Caenorhabditis elegans OX=6239 GN=vps-11
PE=3 SV=2
Length=980
Score = 44.1 bits (102), Expect = 0.008, Method: Composition-based stats.
Identities = 31/204 (15%), Positives = 69/204 (34%), Gaps = 8/204 (4%)
Query 585 RDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAG 644
+ + + + + + LE + S L +Y E + ++
Sbjct 397 KGDYENAIQQYKETIGM--LEPSYVMKRYLDSSKIKELC-IYLECLHDAKRDNEHQTKIL 453
Query 645 KTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQ 704
E+ +L E+ K+ +S D ++ + L E +LL + HE
Sbjct 454 MNAYAKQGEKKKLMEFVNKITDGTRVSRMRDVFEILLKWN---YLAEASLLATKFQMHED 510
Query 705 ALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEP 764
AL + +H + M Y K + + L ++ +H L E +
Sbjct 511 ALNVIIHHMHKYTMGVTYISKMPIESVIEMTGKFGRDLLIHARDDLMHMLWEKIQENTDA 570
Query 765 KANLQAALQVLELHHSKLDTTKAL 788
K N +++ ++ +D ++
Sbjct 571 KKNN--FMRIFDIFMGDMDASRVF 592
>sp|Q9P6N4|PEP5_SCHPO E3 ubiquitin-protein ligase pep5 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=vps11
PE=3 SV=1
Length=906
Score = 41.0 bits (94), Expect = 0.057, Method: Composition-based stats.
Identities = 82/602 (14%), Positives = 184/602 (31%), Gaps = 60/602 (10%)
Query 293 NIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLY 352
+ V ++ V+ L + + +I L Q + LA+ LA+ ++ ++ + Y
Sbjct 341 GFLVVTADDNVFELKRITLQEEISLLCQKMMYNLAISLAKKENMDIEFRE----SLMRDY 396
Query 353 AFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKA 412
A LF + F SM + + L + ++ ++ L A +
Sbjct 397 ASFLFRRGDFSASMDWYIRSIKSIDIPSVCLEFLKAQEIKQLIRLLEELIKTGLATSDHR 456
Query 413 HLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTN 472
L L Y+ S ++KL D + ++D N
Sbjct 457 LLLLSCYVEIHDSPSIRKLIDIGEIDFDQAFKICYDSN--------LLDEAKHLAIRFNN 508
Query 473 VALVAPLLRLENNHC------HIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQ- 525
V +L + ++L KY +++ L EK + +
Sbjct 509 NERVLDVLVESEQYSEALRFFESLPPSNLLPLLLKYGRVLL----DKLPEKTTNIFIQFY 564
Query 526 SKKANSPLKGHERTVQYLQHLGTENLHL-IFSYSVWVLRDFPEDGLKIFTEDLPEVESLP 584
S L E + +L + Y+ P +I +
Sbjct 565 SNSHRGDLSTSESKGELKTAKSLRQTYLSLLPYAQVANFSLPPSLYEISPSQEENQRAAL 624
Query 585 RDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAG 644
+ + + + +L H + N + L+ L
Sbjct 625 FSEDVSYTAPSPQTCFHIFLNHNSELISFLEGILPNA-----SPNYKTLINTCLFEAYIR 679
Query 645 KTPVPAGEEEGEL-GEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHE 703
++ + E+ E E LL +E + + LI G + + G+ G+
Sbjct 680 ESFASSNVEKQEFWQEKSNSLLKKVEKNVDLNAVFLISQIL--GFDDGVRFVQGKSGQTL 737
Query 704 QALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLE 763
+ D A K + +++Y+ +L + S ++ E++
Sbjct 738 DIFRSFCQQ-NDIERAL----KMVRVHGPDQQELYIMMLNCFASLENVDSWYQDINEIV- 791
Query 764 PKANLQAALQVLELHHSKLDTTKALNLLPA--NTQINDIRIFLEKVLEENAQKKRFNQVL 821
N+ + +++ T+ L++L N ++ I ++ VL+ +
Sbjct 792 ---NIIVSQRLIS-------PTQLLDILGKSVNIKLEHISDSMQSVLDNYRESISKQNEA 841
Query 822 KNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEV 881
+ + + + + + ++ E K C C + +VH+ C
Sbjct 842 IEMGKRDIEEITSQLSILRTRAFVVQESK-CSTCGIDLELP---------MVHFRCGHSY 891
Query 882 NP 883
+
Sbjct 892 HQ 893
>sp|P19721|SPIKE_ADEM1 Fiber protein OS=Murine adenovirus A serotype
1 OX=10530 GN=L5 PE=2 SV=1
Length=613
Score = 40.2 bits (92), Expect = 0.086, Method: Composition-based stats.
Identities = 20/116 (17%), Positives = 51/116 (44%), Gaps = 8/116 (7%)
Query 188 IRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIP 247
++V+ +G ++ L PL + ++A+G+ ++++++G L W + P
Sbjct 171 LQVNDQGQLEALAMVHSTSAPLKVTNNNLELALGR---GLIVDDQGQLRLAPNLLWPESP 227
Query 248 VAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFV 303
+A+E ++I + +++ E L ++ GG + +A N +
Sbjct 228 LAIEQGTNHLILFYNQSLDV---EDGKL--TLPEPFDPLTLDGGRLRMQLAPNSGL 278
>sp|P39702|VPS8_YEAST Vacuolar protein sorting-associated protein
8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
OX=559292 GN=VPS8 PE=1 SV=2
Length=1274
Score = 39.1 bits (89), Expect = 0.25, Method: Composition-based stats.
Identities = 61/402 (15%), Positives = 138/402 (34%), Gaps = 80/402 (20%)
Query 496 LKKAHKYSELIILYEKKGLHEKALQVLV---DQSKKANSPLKGHERTVQYLQHLGTENLH 552
LK+ + L +Y+ + + AL +++ D K+ N+
Sbjct 846 LKEKNFNKVLFHIYKSENKYASALSLILETKDIEKEYNTD-------------------- 885
Query 553 LIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPY-LEHIIHVW 611
I S + ++L+ P SL +V + NF L +E + ++
Sbjct 886 -IVSITDYILKKCP-------------PGSLECGKVTEVIETNFDLLLSRIGIEKCVTIF 931
Query 612 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELG---EYRQKLLMFL 668
+ H ++++ E+ Q + L S P V + +Y+ K M L
Sbjct 932 SDFDYNLHQEILEVKNEETQQKYLDKLFSTPNINNKVDKRLRNLHIELNCKYKSKREMIL 991
Query 669 ----EISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDT-------- 716
+ S + +++ D E A++ R+ A+ + ++
Sbjct 992 WLNGTVLSNAESLQILDLLNQDSNFEAAAIIHERLESFNLAVRDLLSFIEQCLNEGKTNI 1051
Query 717 -------RMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLE------ 763
R A + C+ K + L+ +Y PS + +LL+
Sbjct 1052 STLLESLRRAFDDCNSAGTEKKSCWILLITFLITLYGKYPSHDERKDLCNKLLQEAFLGL 1111
Query 764 ----PKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQ 819
+ + + E+ S L+ + + ++ D++ L V ++ ++
Sbjct 1112 VRSKSSSQKDSGGEFWEIMSSVLEHQDVILM-----KVQDLKQLLLNVFNTYKLERSLSE 1166
Query 820 VLKNLLH--AEFLRVQEERILHQQVKCIITEEKVCMVCKKKI 859
+++ ++ ++ L Q + L + + C +C KKI
Sbjct 1167 LIQKIIEDSSQDLVQQYRKFLSEGWSIHTDD---CEICGKKI 1205
>sp|Q9VF81|TMTC4_DROME Protein O-mannosyl-transferase Tmtc4 OS=Drosophila
melanogaster OX=7227 GN=Tmtc4 PE=2 SV=1
Length=705
Score = 38.3 bits (87), Expect = 0.35, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 54/167 (32%), Gaps = 19/167 (11%)
Query 502 YSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWV 561
Y + LY ++ + +AL K + L + G ++ S
Sbjct 549 YYNMGNLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDD--ALRISNQA 606
Query 562 LRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNC 621
L+ P D +F R VLG L + AI + E + +H
Sbjct 607 LQHLPNDVSILFI----------RANVLGKLKHYTEAEAIY---KRVIELEPHNTLYHTN 653
Query 622 LIQLY--CEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLM 666
L LY +K Q ++ Y + + A L + ++L
Sbjct 654 LGVLYHRWDKTQEAIEAYRTAI--SISAARATTARENLSKLLKRLER 698
>sp|Q9LFQ3|SNL2_ARATH Paired amphipathic helix protein Sin3-like
2 OS=Arabidopsis thaliana OX=3702 GN=SNL2 PE=1 SV=2
Length=1367
Score = 37.9 bits (86), Expect = 0.54, Method: Composition-based stats.
Identities = 30/218 (14%), Positives = 66/218 (30%), Gaps = 29/218 (13%)
Query 261 LPRYVEIRTFEPRLLVQSIE-LQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLL 319
++E+ + + R + + G +N+I+ +P + +
Sbjct 71 YDMFLEVMKDFKAQKTDTSGVISRVKELFKGHNNLIF-----GFNTFLPKGFEITLDDVE 125
Query 320 QDKQ----FELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTD 375
+ FE A+ ++ IK + N K F E + ++ K D
Sbjct 126 APSKKTVEFEEAISF--------------VNKIKTRFQHNELVYKSFLEILNMYRKDNKD 171
Query 376 PTHVMGLYPDLLPTDY----RKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL 431
T V L P+ L + A+L ++ D + +
Sbjct 172 ITEVYNEVSTLFEDHSDLLEEFTRFLPDSLAPHTEAQLLRSQAQRYDDRGSGPPLVRRMF 231
Query 432 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYL 469
+ D + + G + L D +++K +
Sbjct 232 MEKDRRRERTVASRGDRDHSVDRSDLND-DKSMVKMHR 268
>sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 OS=Homo sapiens OX=9606
GN=CLTCL1 PE=1 SV=2
Length=1640
Score = 37.5 bits (85), Expect = 0.77, Method: Composition-based stats.
Identities = 39/302 (13%), Positives = 92/302 (30%), Gaps = 23/302 (8%)
Query 543 LQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFL-IENFKGLAI 601
L + EN V R PE + E P L V L
Sbjct 930 LIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPE--- 986
Query 602 PYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYR 661
E + V + N LI+L + V + A + + R
Sbjct 987 ---EISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKAD------R 1037
Query 662 QKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEE 721
+++ ++ YD + L EE + + + A+ + + + + A E
Sbjct 1038 TRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYE 1097
Query 722 Y---CHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELH 778
+ C++ ++ + L++ ++ LE+++ + +++
Sbjct 1098 FAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFL 1157
Query 779 H-------SKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLR 831
T+ + L ++++++ F+ + Q+ + + A L
Sbjct 1158 QMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLL 1217
Query 832 VQ 833
Sbjct 1218 YS 1219
>sp|Q29NU5|GLT25_DROPS Glycosyltransferase 25 family member OS=Drosophila
pseudoobscura pseudoobscura OX=46245 GN=GA16561
PE=3 SV=2
Length=626
Score = 37.1 bits (84), Expect = 0.90, Method: Composition-based stats.
Identities = 35/174 (20%), Positives = 59/174 (34%), Gaps = 24/174 (14%)
Query 516 EKALQVLVDQSKKANSPLKGHERTVQYLQHL--GTENLHLIFSYSVWV-LRDFP------ 566
E+ LQ+L++ S L ++Y Q L E L + + L P
Sbjct 300 EQDLQMLLNIRASMVSDLGAVPPVLEYFQPLIKTPEKTKLTLDHIFMINLERRPERRQKM 359
Query 567 -----EDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWE----ETGSR 617
E GL++ + + L DRV I G PY + + E + R
Sbjct 360 ENLFEEIGLQVEHFPAVDGKELNADRVQEMGIRFLPGYEDPYHHRAMTMGEIGCFLSHYR 419
Query 618 FHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY------RQKLL 665
++QL ++V L + V + + EY R++L
Sbjct 420 IWVRMVQLELKEVLILEDDIRFDPYFRANAVRVLNQARSVVEYDLIYFGRKRLK 473
>sp|Q6MMQ9|MIAA_BDEBA tRNA dimethylallyltransferase OS=Bdellovibrio
bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529
/ HD100) OX=264462 GN=miaA PE=3 SV=1
Length=308
Score = 36.4 bits (82), Expect = 1.0, Method: Composition-based stats.
Identities = 37/215 (17%), Positives = 80/215 (37%), Gaps = 24/215 (11%)
Query 214 ADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAM--EHQPPYIIAVLPRYVEI---- 267
++ + + Q+ V++N + + K + P P Y++ + E+
Sbjct 18 SEWALKLAQEFNGVIVNCDSVQLYKKLDIGSAKPSKAEQALVPHYLLDYVNPPEEMTAGN 77
Query 268 RTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELA 327
+ +++ I +P F+ GG+ ++A ++ +IPVP+ Q Q L+ + E A
Sbjct 78 YCRDFYAILEEIPADKPVFVV-GGTGFYFMAIEKGMYPVIPVPVEIQAQVALELETEEGA 136
Query 328 LQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLY---- 383
++L +D E +IH L + R ++++ G T + +
Sbjct 137 IRLHAEMMKADPEYGAKIH---------LADRYRIGRAIELIRSQGKSVTQIQAEFESQR 187
Query 384 -PD---LLPTDYRKQLQYPNPLPVLSGAELEKAHL 414
P LL + ++ A L
Sbjct 188 KPFPFPLLKIGPSWDREVLRERIGQRVEKMLAAGL 222
>sp|A8XBZ8|BAR1_CAEBR Beta-catenin/armadillo-related protein 1
OS=Caenorhabditis briggsae OX=6238 GN=bar-1 PE=3 SV=3
Length=808
Score = 36.8 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 20/83 (24%), Positives = 30/83 (36%), Gaps = 7/83 (8%)
Query 713 LKDTRMAEEYCHKH-YDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAA 771
+ D M E YC+ D +K N +Y S MY P+ GP
Sbjct 714 MSDDSMMESYCNSSGRDSSKTYNSPMYHSPPSMYPEYPNGPPSGPYYDPHAFTSTRPTPP 773
Query 772 LQVLELHHSKLDTTKALNLLPAN 794
H++ D+ N +P+N
Sbjct 774 ------HYANYDSPPVYNNIPSN 790
>sp|P22137|CLH_YEAST Clathrin heavy chain OS=Saccharomyces cerevisiae
(strain ATCC 204508 / S288c) OX=559292 GN=CHC1 PE=1
SV=1
Length=1653
Score = 36.8 bits (83), Expect = 1.4, Method: Composition-based stats.
Identities = 70/473 (15%), Positives = 146/473 (31%), Gaps = 71/473 (15%)
Query 363 DESMQVFAKLGTDPTHVMGLYPDLLP----TDYRKQLQYPNPLPVLSGAELEKAHL--AL 416
+E+ +++ K + L D++ Y ++ P + A+L+ + A+
Sbjct 1072 EEAFEIYDKHEMYGKALKVLIEDIMSLDRAASYADKINTPELWSQIGTAQLDGLRIPDAI 1131
Query 417 IDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALV 476
Y+ + + + D Q+ + + K ID L+ Y N
Sbjct 1132 ESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTLKEPKIDGALILAYAELNKIHE 1191
Query 477 APLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGH 536
L +N +++ L + +Y + Y + K LV L +
Sbjct 1192 IENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLASTLVY--------LGDY 1243
Query 537 ERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENF 596
+ V + VW L + E + ++ G
Sbjct 1244 QAAVDTARKASNIK--------VWKLVNDACI----------EKKEFKLAQICGL----- 1280
Query 597 KGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGE 656
L + E V + + LI L+ + ++ + + + + E
Sbjct 1281 -NLIVHAEELDELVERYESNGYFEELISLF--EAGLGLERAHMGMFTELAILYS---KYE 1334
Query 657 LGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQ-ALFIYVHILKD 715
+ + L +F + ++I L E L + + AL + KD
Sbjct 1335 PDKTFEHLKLFWSRINI---PKVIRAVEQAHLWSELVFLYAHYDEWDNAALTLIEKSTKD 1391
Query 716 TRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVL 775
A Y + + N ++Y + Y+ LL + +L
Sbjct 1392 LDHA--YFKEVVVKVS--NLEIYYKAINFYVK---------FHPSLL---------VDLL 1429
Query 776 ELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAE 828
+LD + + + + + I+ FL VL +N NQ +L+ E
Sbjct 1430 TSLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSV--VNQAYHDLMIEE 1480
>sp|Q5UNZ2|YR739_MIMIV Putative BTB/POZ domain and WD-repeat protein
R739 OS=Acanthamoeba polyphaga mimivirus OX=212035 GN=MIMI_R739
PE=3 SV=1
Length=490
Score = 36.4 bits (82), Expect = 1.4, Method: Composition-based stats.
Identities = 23/173 (13%), Positives = 58/173 (34%), Gaps = 11/173 (6%)
Query 135 RMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRD----YYLIRV 190
+ KK+ + +F + P+++ N I V Y L+ +
Sbjct 171 YVIFPDSKKIGIVELFGSDFTNKRNYIQTKKSPENITVSSNQIAVSTYSGSIHIYSLMTL 230
Query 191 DGKGSIKEL---FPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIP 247
+ IK L+A + + +++V + V ++ K ++
Sbjct 231 EKIHKIKTSCVKLSYTSDGSYLLAVVRESEISVC---IIVYCSKTFQIVSKINIDDFVNV 287
Query 248 VAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFIT-SGGSNIIYVAS 299
YI+ +++ + ++++ + + + SN Y+AS
Sbjct 288 FCCTSDNKYILVANKTKIDVWDLQTGQFIKTMGICKNKINCIDCSSNNKYIAS 340
>sp|C0PEY7|PYG7_MAIZE Tetratricopeptide repeat domain-containing
protein PYG7, chloroplastic OS=Zea mays OX=4577 GN=PYG7 PE=2
SV=1
Length=321
Score = 35.2 bits (79), Expect = 2.6, Method: Composition-based stats.
Identities = 24/126 (19%), Positives = 41/126 (33%), Gaps = 10/126 (8%)
Query 571 KIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCE-- 628
++ + D E V+ L F AI YL+ I W+ L
Sbjct 181 QVRSGDASATEYFELGAVM--LRRKFYPAAIKYLQQAIDKWDRDEQDLAQVYNALGVSYK 238
Query 629 ---KVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFL---EISSYYDPGRLICD 682
K+ ++++ + V A G+ E ++ L L E +DP +
Sbjct 239 RENKLDKAIQQFQKAVELQPGYVTAWNNLGDAYEQQKDLKSALKAFEEVLLFDPNNKVAR 298
Query 683 FPFDGL 688
D L
Sbjct 299 PRVDDL 304
>sp|Q502L7|KAD8_DANRE Adenylate kinase 8 OS=Danio rerio OX=7955
GN=ak8 PE=2 SV=1
Length=486
Score = 35.2 bits (79), Expect = 2.6, Method: Composition-based stats.
Identities = 25/102 (25%), Positives = 47/102 (46%), Gaps = 5/102 (5%)
Query 655 GELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFI-YVHIL 713
+ + Q L+ FLE + P ++ P G + + ++ +H QA+ I + IL
Sbjct 37 DKPDDPIQYLINFLERDNVDVPRIILLGPPASG----KKTVAKKLCEHTQAIHITFCDIL 92
Query 714 KDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLG 755
KD +YD+ ++ KD+++ L++ LS P G
Sbjct 93 KDDSDLTRAAQSYYDKKQNVPKDLWIQLIQQRLSKPDCVQRG 134
>sp|Q59LR2|ATR_CANAL Serine/threonine-protein kinase MEC1 OS=Candida
albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=MEC1
PE=3 SV=2
Length=2325
Score = 35.6 bits (80), Expect = 3.0, Method: Composition-based stats.
Identities = 55/375 (15%), Positives = 116/375 (31%), Gaps = 51/375 (14%)
Query 449 TIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIE----ESEHVLKKAHKYSE 504
T ++ L + +T + + + L L + N I L+ E
Sbjct 1620 TQRNILTLHNVANTVMKNPAMISKNLLRESSLARKYNRLDISTRSIVQAMSLEDDQANIE 1679
Query 505 LIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRD 564
L +G +A++ L D K + VQ Y+ W+
Sbjct 1680 FAELQWAQGKQSEAIKCLFDILKDNKFHDDKSKAKVQ-------------LQYANWLDES 1726
Query 565 FPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQ 624
+I TE + L + E Y ++ + + + ++
Sbjct 1727 NHLSAHQIITE-------YNKAFHLNMVDEKCNFDIGKYYNKLMESSNDESGEYEHLTVR 1779
Query 625 LYCEKVQGLMKEYLLSFPAGKTP-VPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDF 683
Y V + P T + ++ + +L ++ Y+ I +
Sbjct 1780 NYIRAVSVGTTYIFEALPKVLTIWLDFADKSNKSNAAENRLKQIID--DLYNA---IANV 1834
Query 684 PFDGLLEERALLLGRM-GKHEQALFIYVHILKD-----TRMAEEYCHKHYDRNKDGNKDV 737
P +L R+ +HE + + I+++ + Y H + K
Sbjct 1835 PNYSWYTVLTQILSRIVHEHEPSFKVLKRIVQNVTLEYPKHCVWYIFSHARSSDKVRKRR 1894
Query 738 YLSLLRMYLS-------PPSIHCLGPIKLELLE------PKANLQAALQVLELHHSKLDT 784
LL + P S G + +L++ PK N + + +L+ ++D
Sbjct 1895 VRELLNQVCTQDGNDTLPKSTMAAGNLFAKLIKIAELKIPKTNRKRQMSLLQDF--EVDL 1952
Query 785 TKALNLLPANTQIND 799
++ ++ L Q N
Sbjct 1953 SEPIDDLVIPIQSNL 1967
>sp|Q5BJE1|CC178_HUMAN Coiled-coil domain-containing protein 178
OS=Homo sapiens OX=9606 GN=CCDC178 PE=2 SV=3
Length=867
Score = 34.4 bits (77), Expect = 6.5, Method: Composition-based stats.
Identities = 56/283 (20%), Positives = 105/283 (37%), Gaps = 24/283 (8%)
Query 596 FKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEG 655
I +++ + +E RF + +KE K P + +
Sbjct 95 CVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDE 154
Query 656 ELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFI---YVHI 712
+ E +Q++ L + RLI D E AL R K+ + I V
Sbjct 155 KCPELKQEMETLLS-----EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
Query 713 LKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAAL 772
L++ +A ++ DV + + K EL E A +QA +
Sbjct 210 LQELPLA------VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADI 263
Query 773 QVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLE-ENAQKKRFNQVLKNLLHAEFLR 831
+ H LD+ + N ++ D++ +K +E + +K ++ + L E R
Sbjct 264 DYMNEHGPLLDSKQ-------NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENAR 316
Query 832 VQEERILHQQVKCIITEEKVCMVCKKKI--GNSAFARYPNGVV 872
++ ++I + K I +EK K++I NS F Y + V+
Sbjct 317 LKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVI 359
>sp|O95163|ELP1_HUMAN Elongator complex protein 1 OS=Homo sapiens
OX=9606 GN=ELP1 PE=1 SV=3
Length=1332
Score = 34.1 bits (76), Expect = 8.3, Method: Composition-based stats.
Identities = 39/220 (18%), Positives = 68/220 (31%), Gaps = 34/220 (15%)
Query 515 HEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLI-----FSYSVWVLRDFPEDG 569
H+ L +L KK L+ + V LQ + + Y + ++
Sbjct 833 HKYCLSILTSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLHLVDVNELYD 892
Query 570 LKIFTEDLP------EVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLI 623
+ T D E L FL K + Y I + + + L
Sbjct 893 HSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTL-KKMETNYQRFTIDKYLKRYEKAIGHLS 951
Query 624 QL---YCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLI 680
+ Y + L+K+ L A K P+ + +IS Y +
Sbjct 952 KCGPEYFPECLNLIKDKNLYNEALKLYSPSS-------------QQYQDISIAYGEHLMQ 998
Query 681 CDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE 720
+ E L+ R G HE+AL ++ + + A
Sbjct 999 EH-----MYEPAGLMFARCGAHEKALSAFL-TCGNWKQAL 1032
>sp|Q9VRX2|VPS8_DROME Vacuolar protein sorting-associated protein
8 homolog OS=Drosophila melanogaster OX=7227 GN=Vps8 PE=1
SV=1
Length=1229
Score = 33.7 bits (75), Expect = 9.8, Method: Composition-based stats.
Identities = 18/104 (17%), Positives = 39/104 (38%), Gaps = 0/104 (0%)
Query 425 SQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLEN 484
+ + +L D+ + + K +L LL+ Y + N
Sbjct 911 PEKINELLDNLRREENLLYLFLKCLNDRKSELEASQMELLLELYCKMESSSTVEEFLRSN 970
Query 485 NHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKK 528
+ +E + + + H +I LYEK+ + KA ++ ++ K
Sbjct 971 SGYRLENAIAIAESHHLNRSVIYLYEKQESYAKAFELSMELLKS 1014
>sp|Q88YN5|PHNC_LACPL Phosphonates import ATP-binding protein
PhnC OS=Lactiplantibacillus plantarum (strain ATCC BAA-793 /
NCIMB 8826 / WCFS1) OX=220668 GN=phnC PE=3 SV=1
Length=256
Score = 32.9 bits (73), Expect = 10.0, Method: Composition-based stats.
Identities = 25/152 (16%), Positives = 51/152 (34%), Gaps = 2/152 (1%)
Query 627 CEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFD 686
+ L+++ T + + EL + R + M + + P + +
Sbjct 45 LRSINQLIRDDSGQILLDDTDIRQA-NKAELRKVRHHIGMIFQNYNLISPLTALENVL-H 102
Query 687 GLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYL 746
G L ++ + G +G + A L D +EY ++ D+ G + +
Sbjct 103 GRLGAKSTVAGMLGLYSSAEKQEALQLLDEVGLKEYAYQRCDQLSGGQQQRVGIARALMQ 162
Query 747 SPPSIHCLGPIKLELLEPKANLQAALQVLELH 778
P I C PI + + L+ L
Sbjct 163 HPKMILCDEPIASLDPKSTTIVMDILRRLAKE 194
Lambda K H a alpha
0.317 0.118 0.267 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0361 0.140 1.90 42.6 43.6
Effective search space used: 101801316738
Database: uniprot_sprot.fasta
Posted date: Apr 3, 2024 12:05 PM
Number of letters in database: 206,678,396
Number of sequences in database: 571,282
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40