PSIBLAST 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Stephen F.
Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005)
"Protein database searches using compositionally adjusted
substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: uniprot_sprot.fasta
572,214 sequences; 207,235,166 total letters
Results from round 1
Query= sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens
OX=9606 GN=TPCN2 PE=1 SV=2
Length=752
Score E
Sequences producing significant alignments: (Bits) Value
sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens O... 1533 0.0
sp|Q8BWC0|TPC2_MOUSE Two pore channel protein 2 OS=Mus musculus O... 1089 0.0
sp|A0JMD4|TPC2_DANRE Two pore channel protein 2 OS=Danio rerio OX... 838 0.0
sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Hordeu... 166 1e-41
sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabid... 165 3e-41
sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nico... 164 6e-41
sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nico... 162 2e-40
sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Tritic... 160 1e-39
sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza ... 159 3e-39
sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus n... 153 3e-37
sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus mu... 152 8e-37
sp|Q9ULQ1|TPC1_HUMAN Two pore channel protein 1 OS=Homo sapiens O... 148 1e-35
sp|O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel su... 82.8 8e-15
sp|Q9EQ60|CAC1H_RAT Voltage-dependent T-type calcium channel subu... 82.4 1e-14
sp|Q9R053|SCNBA_MOUSE Sodium channel protein type 11 subunit alph... 82.4 1e-14
sp|O88427|CAC1H_MOUSE Voltage-dependent T-type calcium channel su... 82.0 1e-14
sp|Q24270|CAC1D_DROME Voltage-dependent calcium channel type D su... 81.6 2e-14
sp|Q25452|CAC1M_MUSDO Muscle calcium channel subunit alpha-1 OS=M... 78.2 2e-13
sp|O54898|CAC1G_RAT Voltage-dependent T-type calcium channel subu... 77.4 4e-13
sp|Q2XVR3|SC4AA_DANRE Sodium channel protein type 4 subunit alpha... 75.9 1e-12
sp|O43497|CAC1G_HUMAN Voltage-dependent T-type calcium channel su... 75.9 1e-12
sp|O88457|SCNBA_RAT Sodium channel protein type 11 subunit alpha ... 75.1 2e-12
sp|O57483|CAC1S_AQUCT Voltage-dependent L-type calcium channel su... 73.2 6e-12
sp|Q02294|CAC1B_RAT Voltage-dependent N-type calcium channel subu... 70.5 4e-11
sp|P56698|CAC1B_DIPOM Probable voltage-dependent N-type calcium c... 69.7 9e-11
sp|Q61290|CAC1E_MOUSE Voltage-dependent R-type calcium channel su... 69.3 1e-10
sp|P0DMA5|SCNAA_ONYTO Sodium channel protein type 10 subunit alph... 69.3 1e-10
sp|Q07652|CAC1E_RAT Voltage-dependent R-type calcium channel subu... 69.3 1e-10
sp|O55017|CAC1B_MOUSE Voltage-dependent N-type calcium channel su... 68.9 1e-10
sp|Q02485|CAC1S_RAT Voltage-dependent L-type calcium channel subu... 68.6 2e-10
sp|Q9P0X4|CAC1I_HUMAN Voltage-dependent T-type calcium channel su... 68.6 2e-10
sp|P27884|CAC1A_RABIT Voltage-dependent P/Q-type calcium channel ... 68.2 2e-10
sp|Q13698|CAC1S_HUMAN Voltage-dependent L-type calcium channel su... 68.2 3e-10
sp|Q9Z0Y8|CAC1I_RAT Voltage-dependent T-type calcium channel subu... 68.2 3e-10
sp|Q2XVR7|SC4AA_TAKRU Sodium channel protein type 4 subunit alpha... 68.2 3e-10
sp|P07293|CAC1S_RABIT Voltage-dependent L-type calcium channel su... 67.8 3e-10
sp|P97445|CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel ... 67.8 3e-10
sp|Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel su... 67.8 3e-10
sp|Q00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel su... 67.8 3e-10
sp|Q2XVR4|SC4AB_TETNG Sodium channel protein type 4 subunit alpha... 67.4 4e-10
sp|Q6QIY3|SCNAA_MOUSE Sodium channel protein type 10 subunit alph... 67.4 5e-10
sp|Q02343|CAC1E_RABIT Voltage-dependent R-type calcium channel su... 67.4 5e-10
sp|P56699|CAC1E_DIPOM Probable voltage-dependent R-type calcium c... 67.0 5e-10
sp|Q02789|CAC1S_MOUSE Voltage-dependent L-type calcium channel su... 66.6 8e-10
sp|Q05152|CAC1B_RABIT Voltage-dependent N-type calcium channel su... 65.9 1e-09
sp|O00555|CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel ... 65.5 2e-09
sp|P22002|CAC1C_RAT Voltage-dependent L-type calcium channel subu... 63.9 4e-09
sp|P54282|CAC1A_RAT Voltage-dependent P/Q-type calcium channel su... 63.2 8e-09
sp|P22316|CAC1S_CYPCA Dihydropyridine-sensitive L-type skeletal m... 62.8 1e-08
sp|O46669|SCNAA_CANLF Sodium channel protein type 10 subunit alph... 62.4 2e-08
sp|Q2XVR6|SC4AB_TAKRU Sodium channel protein type 4 subunit alpha... 62.4 2e-08
sp|Q01815|CAC1C_MOUSE Voltage-dependent L-type calcium channel su... 62.0 2e-08
sp|Q9JIS7|CAC1F_MOUSE Voltage-dependent L-type calcium channel su... 62.0 2e-08
sp|O73700|CAC1D_CHICK Voltage-dependent L-type calcium channel su... 62.0 2e-08
sp|P15381|CAC1C_RABIT Voltage-dependent L-type calcium channel su... 61.6 3e-08
sp|O88420|SCN8A_RAT Sodium channel protein type 8 subunit alpha O... 61.6 3e-08
sp|Q2XVR5|SC4AA_TETNG Sodium channel protein type 4 subunit alpha... 61.6 3e-08
sp|Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel su... 61.2 3e-08
sp|P91645|CAC1A_DROME Voltage-dependent calcium channel type A su... 61.2 3e-08
sp|P02719|SCNA_ELEEL Sodium channel protein OS=Electrophorus elec... 60.8 4e-08
sp|Q9Y5Y9|SCNAA_HUMAN Sodium channel protein type 10 subunit alph... 60.8 5e-08
sp|C9D7C2|CAC1A_APIME Voltage-dependent calcium channel type A su... 60.8 5e-08
sp|P35500|SCNA_DROME Sodium channel protein para OS=Drosophila me... 60.5 6e-08
sp|Q9UI33|SCNBA_HUMAN Sodium channel protein type 11 subunit alph... 59.7 1e-07
sp|Q9WTU3|SCN8A_MOUSE Sodium channel protein type 8 subunit alpha... 58.9 2e-07
sp|O60840|CAC1F_HUMAN Voltage-dependent L-type calcium channel su... 58.9 2e-07
sp|Q01668|CAC1D_HUMAN Voltage-dependent L-type calcium channel su... 58.5 2e-07
sp|Q9UQD0|SCN8A_HUMAN Sodium channel protein type 8 subunit alpha... 58.5 2e-07
sp|Q91ZR5|CTSR1_MOUSE Cation channel sperm-associated protein 1 O... 57.4 4e-07
sp|O35505|CAC1C_CAVPO Voltage-dependent L-type calcium channel su... 57.8 4e-07
sp|Q99246|CAC1D_MOUSE Voltage-dependent L-type calcium channel su... 57.8 4e-07
sp|P15389|SCN5A_RAT Sodium channel protein type 5 subunit alpha O... 57.4 5e-07
sp|Q9JJV9|SCN5A_MOUSE Sodium channel protein type 5 subunit alpha... 57.4 5e-07
sp|Q99244|CAC1D_MESAU Voltage-dependent L-type calcium channel su... 56.6 8e-07
sp|P08104|SCN3A_RAT Sodium channel protein type 3 subunit alpha O... 57.0 8e-07
sp|Q9NY46|SCN3A_HUMAN Sodium channel protein type 3 subunit alpha... 56.6 9e-07
sp|P04774|SCN1A_RAT Sodium channel protein type 1 subunit alpha O... 56.2 1e-06
sp|A2ASI5|SCN3A_MOUSE Sodium channel protein type 3 subunit alpha... 56.2 1e-06
sp|A2APX8|SCN1A_MOUSE Sodium channel protein type 1 subunit alpha... 55.8 1e-06
sp|Q9ER60|SCN4A_MOUSE Sodium channel protein type 4 subunit alpha... 55.8 1e-06
sp|Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha... 55.8 1e-06
sp|P15390|SCN4A_RAT Sodium channel protein type 4 subunit alpha O... 55.8 2e-06
sp|Q28371|SCN4A_HORSE Sodium channel protein type 4 subunit alpha... 54.7 4e-06
sp|Q14524|SCN5A_HUMAN Sodium channel protein type 5 subunit alpha... 54.3 4e-06
sp|Q9W0Y8|SCN60_DROME Sodium channel protein 60E OS=Drosophila me... 54.3 4e-06
sp|Q62968|SCNAA_RAT Sodium channel protein type 10 subunit alpha ... 54.3 5e-06
sp|P35499|SCN4A_HUMAN Sodium channel protein type 4 subunit alpha... 53.9 5e-06
sp|Q62205|SCN9A_MOUSE Sodium channel protein type 9 subunit alpha... 53.9 7e-06
sp|P27732|CAC1D_RAT Voltage-dependent L-type calcium channel subu... 53.5 7e-06
sp|P35498|SCN1A_HUMAN Sodium channel protein type 1 subunit alpha... 53.5 8e-06
sp|Q05973|SCN1_HETBL Sodium channel protein 1 brain OS=Heterololi... 52.4 2e-05
sp|Q28644|SCN9A_RABIT Sodium channel protein type 9 subunit alpha... 52.4 2e-05
sp|D0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1 OS=Periplanet... 51.2 4e-05
sp|Q20JQ7|SC4AB_DANRE Sodium channel protein type 4 subunit alpha... 51.2 4e-05
sp|O08562|SCN9A_RAT Sodium channel protein type 9 subunit alpha O... 50.4 6e-05
sp|Q8BVN3|CTSR4_MOUSE Cation channel sperm-associated protein 4 O... 49.7 7e-05
sp|Q99250|SCN2A_HUMAN Sodium channel protein type 2 subunit alpha... 50.1 8e-05
sp|O42398|CAC1S_CHICK Voltage-dependent L-type calcium channel su... 48.9 9e-05
sp|B1AWN6|SCN2A_MOUSE Sodium channel protein type 2 subunit alpha... 50.1 9e-05
sp|P04775|SCN2A_RAT Sodium channel protein type 2 subunit alpha O... 50.1 9e-05
sp|A2ARP9|CTSR2_MOUSE Cation channel sperm-associated protein 2 O... 49.3 1e-04
sp|Q8BXR5|NALCN_MOUSE Sodium leak channel NALCN OS=Mus musculus O... 49.7 1e-04
sp|Q8IZF0|NALCN_HUMAN Sodium leak channel NALCN OS=Homo sapiens O... 49.7 1e-04
sp|Q6Q760|NALCN_RAT Sodium leak channel NALCN OS=Rattus norvegicu... 49.7 1e-04
sp|Q96P56|CTSR2_HUMAN Cation channel sperm-associated protein 2 O... 48.9 2e-04
sp|Q7RTX7|CTSR4_HUMAN Cation channel sperm-associated protein 4 O... 47.4 4e-04
sp|Q6AXP6|CTSR2_RAT Cation channel sperm-associated protein 2 OS=... 45.8 0.002
sp|A2A259|PK2L1_MOUSE Polycystin-2-like protein 1 OS=Mus musculus... 43.5 0.008
sp|Q9P0L9|PK2L1_HUMAN Polycystin-2-like protein 1 OS=Homo sapiens... 43.5 0.009
sp|Q01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha... 42.4 0.018
sp|Q8NEC5|CTSR1_HUMAN Cation channel sperm-associated protein 1 O... 41.6 0.031
sp|P50077|CCH1_YEAST Calcium-channel protein CCH1 OS=Saccharomyce... 41.6 0.039
sp|Q80W99|CTSR3_MOUSE Cation channel sperm-associated protein 3 O... 37.7 0.37
sp|B1AYL1|SCN7A_MOUSE Sodium channel protein type 7 subunit alpha... 38.1 0.44
sp|F1LQQ7|SCN7A_RAT Sodium channel protein type 7 subunit alpha O... 37.4 0.63
sp|Q86XQ3|CTSR3_HUMAN Cation channel sperm-associated protein 3 O... 37.0 0.69
sp|Q3APT3|TRPD_CHLCH Anthranilate phosphoribosyltransferase OS=Ch... 34.7 2.9
sp|A1VD65|RSMA_NITV4 Ribosomal RNA small subunit methyltransferas... 34.3 3.2
sp|O14234|CCH1_SCHPO Calcium-channel protein cch1 OS=Schizosaccha... 34.7 4.8
sp|A8XSV3|NBEA_CAEBR Putative neurobeachin homolog OS=Caenorhabdi... 34.7 5.1
sp|Q9DEI1|PRKDC_XENLA DNA-dependent protein kinase catalytic subu... 33.9 7.2
sp|A9KIR8|NAGB_LACP7 Glucosamine-6-phosphate deaminase OS=Lachnoc... 33.1 8.3
sp|Q19317|NBEA_CAEEL Putative neurobeachin homolog OS=Caenorhabdi... 33.9 8.8
sp|Q5Y4W4|TAG2X_AGEOR U2-agatoxin-Ao1x OS=Agelena orientalis OX=2... 30.4 9.5
>sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens
OX=9606 GN=TPCN2 PE=1 SV=2
Length=752
Score = 1533 bits (3968), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 752/752 (100%), Positives = 752/752 (100%), Gaps = 0/752 (0%)
Query 1 MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60
MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
Sbjct 1 MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60
Query 61 SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
Sbjct 61 SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
Sbjct 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
Sbjct 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
Sbjct 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
Sbjct 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
Sbjct 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
Sbjct 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
Sbjct 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
Sbjct 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
Sbjct 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
Query 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
Sbjct 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
Query 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752
TVELLFRDILEEPGEDELTERLSQHPHLWLCR
Sbjct 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752
>sp|Q8BWC0|TPC2_MOUSE Two pore channel protein 2 OS=Mus musculus
OX=10090 GN=Tpcn2 PE=1 SV=1
Length=731
Score = 1089 bits (2816), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 548/747 (73%), Positives = 632/747 (85%), Gaps = 18/747 (2%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
AE +PLLG RG G QV GAAA +LCIDQAVVFIEDAI+YRSI HR
Sbjct 3 AEEQPLLGRDRGSG-------------QVHSGAAADQELCIDQAVVFIEDAIKYRSIYHR 49
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+DA S+WLYR YYSNVCQR L F IFLIL LAF+E PSS T TADVRYR+ PW+PPCGLT
Sbjct 50 MDAGSLWLYRWYYSNVCQRVLGFIIFLILILAFVEVPSSFTKTADVRYRSQPWQPPCGLT 109
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLR 185
E++E CLL F DLSVKGYL G A Q+NLWLL Y +VLVVS+VDW VSLSL C EPLR
Sbjct 110 ETIEAFCLLAFLVDLSVKGYLVGQAQLQQNLWLLAYFMVLVVSVVDWIVSLSLACEEPLR 169
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT+ GMLLF G++D+
Sbjct 170 MRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDE 229
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
QD+ERL YF+NLPE+LTSLLVLLTT+NNPDVMIPAY++NRA+A+FFIVFT+IGSLFLMN
Sbjct 230 AQDQERLAYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAFALFFIVFTLIGSLFLMN 289
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
LLTAIIY+QFRGYLMKSLQTSLFRRRLG RAA+EVL+S G G P+ VGV P+ L V
Sbjct 290 LLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPELVGVNPETFLPV 349
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
LQK QL+ +HKQA+M+KV+SY + A+EFQKLF+E+D+ + KE P +P+YQSPFLQ+A
Sbjct 350 LQKTQLNKTHKQAIMQKVQSYEGRPMLADEFQKLFDEVDKGLAKERPLKPQYQSPFLQTA 409
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
QF+F H+YFDYLGNL+AL NL+SICVFLVLD+D+LP ERDDF+LGIL+ +FI+YYLLE+L
Sbjct 410 QFIFSHHYFDYLGNLVALGNLLSICVFLVLDSDLLPGERDDFVLGILDYIFILYYLLELL 469
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
KVFALGL GYLSY SNVFDGLLT++LLV EI TLAVYRLPH GW+PE G LSLWDMTR
Sbjct 470 FKVFALGLPGYLSYHSNVFDGLLTIILLVSEICTLAVYRLPHSGWKPEQYGPLSLWDMTR 529
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++N LIVFRFLRIIP++K MA VA+T+LGL+ N+RAFGGILVV YYVFA+IGINLFRGVI
Sbjct 530 LMNTLIVFRFLRIIPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVI 589
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
V PGNSSL P N SA CGSFEQL YW NNFDDFAAAL+TLWN+MVVNNWQV L+AY+RY
Sbjct 590 VP-PGNSSLVPDNNSAVCGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAYKRY 648
Query 666 SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+GPWS +YFVLWWLVSSVIW+NLFLAL+LENFLH+WDP+ H Q L GT QM+VEL+
Sbjct 649 AGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLVGTK----QMSVELM 704
Query 726 FRDILEEPGEDELTERLSQHPHLWLCR 752
FRDILEEP E+EL E+L +HPHL LCR
Sbjct 705 FRDILEEPKEEELMEKLHKHPHLHLCR 731
>sp|A0JMD4|TPC2_DANRE Two pore channel protein 2 OS=Danio rerio
OX=7955 GN=tpcn2 PE=2 SV=1
Length=774
Score = 838 bits (2166), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 433/777 (56%), Positives = 566/777 (73%), Gaps = 39/777 (5%)
Query 7 ESEPLLGGA-RGGGGDWPAGL--------------------TTYRSIQVGPGAAARWDLC 45
E EPLL G+ G GD+ A T S V A A DL
Sbjct 2 EEEPLLAGSINQGSGDYGAHSESCLHYPDEHTPRSRRLSYSVTDDSCNVEEDADA--DLY 59
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSL 105
+ QAVVFIEDAI+YRSINHRVD+ S+ LYR YYSN+CQ L TI ++L LAFIE PSSL
Sbjct 60 VQQAVVFIEDAIKYRSINHRVDSGSLRLYRWYYSNLCQWGLGLTIAVVLALAFIERPSSL 119
Query 106 TSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVL 165
T T+D+R + PWEPPCG+TE +E++CL +F D++ KGYL GW F+ N WLL YL+V+
Sbjct 120 TYTSDIRVKPKPWEPPCGMTEGIEIVCLCIFILDVTAKGYLIGWEEFRMNKWLLAYLIVI 179
Query 166 VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
S++DW +S+S++C E LR+RRL+RPFFLLQNSS+MKKTLKCI+ +LPE+ASV LLLA+
Sbjct 180 TASVIDWMLSISMLCDENLRVRRLIRPFFLLQNSSLMKKTLKCIKRTLPEIASVILLLAL 239
Query 226 HLCLFTMFGMLLFAGGKQDD-GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
H+CLFTM GML+FA K DD Q+ E TYF+NLP++L+SLLVLLTTANNPDVMIPAYS
Sbjct 240 HICLFTMIGMLIFA--KSDDPKQNGEWQTYFRNLPKALSSLLVLLTTANNPDVMIPAYSL 297
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
NR Y+IFFI+F+V G+ LMNL+TAIIY+QFRGYL+ S+QTS+ RRRLG RAAFEVL
Sbjct 298 NRGYSIFFILFSVFGTYLLMNLMTAIIYNQFRGYLLMSVQTSIIRRRLGIRAAFEVLCC- 356
Query 345 VGEGGAFPQAVG----VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLF 400
G G QA G V L+V+++V + S +QA+++ R + +S E+FQ+LF
Sbjct 357 PGRGHTSTQAEGHVERVAVSMFLKVMERVHMKSYCRQAIVKAARRFPDGFISGEDFQRLF 416
Query 401 NELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL 460
NELD+ VKEHPP+PEY S LQ Q+++ HYY LGN +ALAN++ IC LVL+A+
Sbjct 417 NELDKDFVKEHPPKPEYSSSGLQHIQYVYSHYYISVLGNAVALANVICICTVLVLNAEKS 476
Query 461 PAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTL 520
+E++ F + I+NC+FI+YYL+EMLLK+ A G +GYLSY +N+FDG LTV+LL ++I
Sbjct 477 ASEKNYFYMEIINCIFILYYLIEMLLKIVAFGWKGYLSYRNNIFDGFLTVLLLAIQIVIF 536
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+++P+ P +++LW+M R++NMLIVFRFLRIIP +KLMAVVAST++ LV+N+R
Sbjct 537 ITFKIPYVDVDPVPRHVMALWEMIRLVNMLIVFRFLRIIPEIKLMAVVASTIVDLVKNLR 596
Query 581 AFGGILVVVYYVFAIIGINLFRGVI-----VALPGNSSLAPANG--SAPCGSFEQLEYWA 633
AF GIL+VVYY+FA++GI LF+G I ++L NSSL G S CG+FEQLEYW
Sbjct 597 AFAGILLVVYYMFAVLGIWLFQGAISPPSNMSLVSNSSLENITGPYSMECGTFEQLEYWP 656
Query 634 NNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
NNFDDFA++L+ L+N+MVVNNW VF DAY RY+ WS +YFV+WWL SSV+WVNLF+ALI
Sbjct 657 NNFDDFASSLILLYNIMVVNNWHVFTDAYARYTTDWSLVYFVVWWLTSSVMWVNLFVALI 716
Query 694 LENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWL 750
LENF +KWD RS+ + YQ TV+L+F++ ++EP E+EL +L QHPHL L
Sbjct 717 LENFTYKWD-RSNGLSVEDVERIAYQSTVQLMFKEHVKEPTEEELLAQLHQHPHLHL 772
>sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Hordeum
vulgare OX=4513 GN=TPC1 PE=2 SV=1
Length=742
Score = 166 bits (419), Expect = 1e-41, Method: Compositional matrix adjust.
Identities = 140/487 (29%), Positives = 238/487 (49%), Gaps = 45/487 (9%)
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
T F + +L + VL TT+NNPDV +PAY +R Y++FFIV+ ++G FL NL+ A+IY
Sbjct 259 TIFSSYGVTLYQMFVLFTTSNNPDVWVPAYKISRWYSLFFIVYVLLGVYFLTNLILAVIY 318
Query 313 SQFRGYLMKSL-QTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
F+ K L Q R+ + + AFE++ + G + + N L + +
Sbjct 319 DSFKEQFAKQLVQVDAIRKNI-LQKAFELIDT--NTRGYLDREQCISLLNELNKYRSLPK 375
Query 372 DSSHK-QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR-----PEYQSPFLQSA 425
S + + ++ G +++EEF L N + KE PP P Y SP
Sbjct 376 TSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFPFYHSPVCGRL 435
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD----DFILGILNCVFIVYYL 481
+ F+Y+ + L NLV++ + LD + ++ +F LG + Y+
Sbjct 436 KSFVRSRTFEYIIVFVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWI-------YV 488
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLW 541
EM LK+F+LG Y N FD +LT + + E T A P + LS
Sbjct 489 AEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAF---------PSKLPFLSNG 539
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R L + V R RI+ ++ V +T L+ ++ + GI+ + ++ +G+ +F
Sbjct 540 EWIRYLLLGRVLRLTRILLQVQRFRVFVATFFTLMSSLMPYLGIVFCILCMYCSLGLQIF 599
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
G++ A GN +L + + +Y NF+D+ + +VTL+NL+V+ NWQV++++
Sbjct 600 GGIVYA--GNPTLEETDLFSN-------DYLLFNFNDYPSGMVTLFNLLVMGNWQVWMES 650
Query 662 YRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF-----LHKWDPRSHLQPLAGTPE 715
Y + +G WS IYFV ++L+S ++ +NL +A +LE F L K + P +G +
Sbjct 651 YWQLTGSSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQSPTSGGIK 710
Query 716 ATYQMTV 722
M V
Sbjct 711 KRRSMRV 717
>sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabidopsis
thaliana OX=3702 GN=TPC1 PE=1 SV=1
Length=733
Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust.
Identities = 186/748 (25%), Positives = 326/748 (44%), Gaps = 122/748 (16%)
Query 8 SEPLLGGARGGGGDWPAGLTTYRSIQVGPG-----AAARWDLCIDQAVVFIEDAIQYRSI 62
+PL+G GGG RS + G AAA DL D + +E
Sbjct 2 EDPLIGRDSLGGG---GTDRVRRSEAITHGTPFQKAAALVDLAEDGIGLPVE-------- 50
Query 63 NHRVDASSMWLYRRYYSNVCQRTL--SFTIFLILFLAFIETP-----SSLTSTADVRYRA 115
+D SS RYY + L S F +LFL F E P + S D Y
Sbjct 51 --ILDQSSFGESARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYY 108
Query 116 APWEPPCGLTESV--EVLCLLVFAAD----LSVKGYLFGWAHFQKNLWLLGYLVVLVVSL 169
P ES+ EV+ L + +S +G W + NL + +V+L V +
Sbjct 109 LGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSRIFWTS-RLNLVKVACVVILFVDV 167
Query 170 VDWTVSLSLVCHE--PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ + LS + + P RI +R + + ++ TL + L ++ L + L
Sbjct 168 LVDFLYLSPLAFDFLPFRIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFL 227
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
+ ++F +Q LT F + +L + +L TT+NNPDV IPAY +R
Sbjct 228 LFASWIAFVMFEDTQQG-------LTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRW 280
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQ-TSLFRRRLGTRAAFEVLSSMVG 346
++FF+++ +IG F+ NL+ A++Y F+ L K + +RR+ +A + S G
Sbjct 281 SSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNG 340
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSV-LLSAEEFQKLFNELDR 405
E +D + + E++ +Y ++ +S EEF +F+ELD
Sbjct 341 E-----------------------IDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 377
Query 406 S--------------------VVKEHPPR-----PE-YQSPFLQSAQFLFGHYYFDYLGN 439
+ KE P P+ Y S Q + F Y +
Sbjct 378 TRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAIS 437
Query 440 LIALANLVSICVFLVLDADVLPAER----DDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
I + N +++ V LD + A++ +F+ G + Y+LEM LK++ G
Sbjct 438 FILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWI-------YVLEMALKIYTYGFEN 490
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y +N FD L+T V+++ E +T P+ S + R L + + R
Sbjct 491 YWREGANRFDFLVTWVIVIGETATFIT---------PDENTFFSNGEWIRYLLLARMLRL 541
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
+R++ +++ +T + L+ ++ + G + V ++ IG+ +F G++ A GN L
Sbjct 542 IRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNA--GNKKLF 599
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYF 674
+ +Y NF+D+ +VTL+NL+V+ NWQV++++Y+ +G WS YF
Sbjct 600 ET-------ELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYF 652
Query 675 VLWWLVSSVIWVNLFLALILENFLHKWD 702
V +++++ ++ +NL +A +LE F + D
Sbjct 653 VSFYVITILLLLNLVVAFVLEAFFTELD 680
>sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nicotiana
tabacum OX=4097 GN=TPC1A PE=2 SV=1
Length=735
Score = 164 bits (414), Expect = 6e-41, Method: Compositional matrix adjust.
Identities = 145/615 (24%), Positives = 275/615 (45%), Gaps = 74/615 (12%)
Query 162 LVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGL 221
L++LV +V + + L+ + P RI LR F + N ++ + + L +V
Sbjct 165 LLILVADIVVYILFLADFYYLPFRIAPYLRVVFFILNIRELRDSFFILAGMLGTYLNVVA 224
Query 222 LLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
L A+ L + + F +Q T F + +L + VL TT+NNPDV IPA
Sbjct 225 LSALFLLFSSWLAYVFFEDTRQGK-------TTFTSYGTTLYQMFVLFTTSNNPDVWIPA 277
Query 282 YSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVL 341
Y +R Y +FF+++ ++G F+ NL+ A++Y F+ L+K + R + AF ++
Sbjct 278 YKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVADKDRLRLRTLKKAFSLI 337
Query 342 SSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
G + + + L + ++ +++ ++ G ++ +EF L
Sbjct 338 DE-ANNGHLNEKQCTLLFEELNKYRTLPKISGDDFKSIFSELDDTGDFKINLDEFADLCT 396
Query 402 ELDRSVVKE-------------HPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS 448
+ KE H P E F++ A F+Y+ + L NLV+
Sbjct 397 AIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFVRGAT-------FEYIIVFVLLVNLVA 449
Query 449 ICVFLVLDADVLPA----ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
+ + LD ++ +F G L Y++EM LKV+ G Y N F
Sbjct 450 VIIETTLDIQNNSGQTFWQKVEFTFGWL-------YVIEMALKVYTYGFENYWRDGQNRF 502
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL 564
D ++T V+++ E +T P+ + LS + R L + + R +R++ ++
Sbjct 503 DFVVTWVIVIGETATFVA---------PDGLTFLSNGEWIRYLLIARMLRLIRLLMHVER 553
Query 565 MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
+T L+ ++ + G + + + +G+ +F G++ GN +LA + +
Sbjct 554 YRAFVATFFTLIPSLVPYLGTIFCILCFYCSLGLQIFGGIVNT--GNPNLAQTDLAGN-- 609
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSV 683
+Y NF+D+ +VTL+N++V+ NWQV++ +Y+ +G W+ YFV ++L+S +
Sbjct 610 -----DYLLFNFNDYPNGMVTLFNILVMGNWQVWMQSYKELTGTAWTYAYFVSFYLISVL 664
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPE------------ATYQMTVELLFRDILE 731
+NL +A +LE F + D + + + G + T V+ L +L
Sbjct 665 WLLNLIVAFVLEAFQAEVDLEASARCVDGDDKEAKSERRRNVGTKTRSQRVDFLLHHMLR 724
Query 732 EPGEDELTERLSQHP 746
ELTE +++P
Sbjct 725 S----ELTECSNENP 735
>sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nicotiana
tabacum OX=4097 GN=TPC1B PE=2 SV=1
Length=735
Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust.
Identities = 145/597 (24%), Positives = 265/597 (44%), Gaps = 80/597 (13%)
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
P RI LR F + N ++ + + L +V L A+ L + + F +
Sbjct 186 PFRIAPYLRVVFFILNIRELRDSFFILAGMLGTYLNVVALSALFLLFSSWLAYVFFEDTR 245
Query 243 QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLF 302
Q T F + +L + VL TT+NNPDV IPAY +R Y +FF+++ ++G F
Sbjct 246 QGK-------TTFTSYGTTLYQMFVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYF 298
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGV---KP 359
+ NL+ A++Y F+ L+K + R + AF ++ G + +
Sbjct 299 VTNLILAVVYDSFKSELVKQVADKDRLRLRTLKKAFSLIDE--ANNGLLNEKQCTLLFEE 356
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKE--------- 410
N + L K+ D +++ ++ G ++ EEF L + + KE
Sbjct 357 LNKYRTLPKISGDDF--KSIFNELDDTGDFKINLEEFADLCSAIGLRFQKEDSLPIFEAC 414
Query 411 ----HPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA---- 462
H P E F++ A F+Y+ + L NLV++ + LD
Sbjct 415 PNFYHSPASEKLRGFIRGAT-------FEYIIVFVLLVNLVAVIIETTLDIQNNSGQTFW 467
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
++ +F G L Y++EM LKV+ G Y N FD ++T V+++ E +T
Sbjct 468 QKVEFTFGWL-------YVIEMALKVYTYGFENYWRDGQNRFDFIVTWVIVIGETTTFVA 520
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
P+ + LS + R L + + R +R++ ++ +T L L+ ++ +
Sbjct 521 ---------PDDLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVATFLTLIPSLMPY 571
Query 583 GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
G + + + +G+ +F G++ GN +LA + + +Y NF+D+
Sbjct 572 LGTIFCILCFYCSLGLQIFGGIVNT--GNPNLAQTDLAGN-------DYLLFNFNDYPNG 622
Query 643 LVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKW 701
+VTL+N++V+ NWQV++ +Y+ +G W+ YFV ++L+S + +NL +A +LE F +
Sbjct 623 MVTLFNILVMGNWQVWMQSYKELTGTSWTYAYFVSFYLISVLWLLNLIVAFVLEAFQAEM 682
Query 702 DPRSHLQPLAGTPE------------ATYQMTVELLFRDILEEPGEDELTERLSQHP 746
D + + + G + T V+ L +L ELTE + +P
Sbjct 683 DLEASARCVDGDDKEAKRERRRNVGTKTRSQRVDFLLHHMLRS----ELTECSNDNP 735
>sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Triticum
aestivum OX=4565 GN=TPC1 PE=2 SV=1
Length=742
Score = 160 bits (404), Expect = 1e-39, Method: Compositional matrix adjust.
Identities = 139/487 (29%), Positives = 234/487 (48%), Gaps = 45/487 (9%)
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
T F + +L + VL TT+NNPDV + AY R Y++FFIV+ ++G FL NL+ A+IY
Sbjct 259 TIFSSYGVTLYQMFVLFTTSNNPDVWVHAYKIPRWYSLFFIVYVLLGVYFLTNLILAVIY 318
Query 313 SQFRGYLMKSL-QTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
F+ K L Q R+ + + AF+++ + G + + N L + +
Sbjct 319 DSFKEQFAKQLVQVDSIRKNI-LQKAFDLIDT--NNRGYLDREQCISLLNELNKYRSLPK 375
Query 372 DSSHK-QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR-----PEYQSPFLQSA 425
S + + ++ G +++EEF L N + KE PP P Y SP
Sbjct 376 TSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFPFYHSPLCGRL 435
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD----DFILGILNCVFIVYYL 481
+ F+Y+ + L NLV++ + LD + ++ +F LG + Y+
Sbjct 436 KSFVRSRMFEYIIVFVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWI-------YV 488
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLW 541
EM LK+F+LG Y N FD +LT + + E T A P + LS
Sbjct 489 AEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAF---------PSKLPFLSNG 539
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R L + V R RI+ ++ +T L+ ++ + GI+ V ++ IG+ +F
Sbjct 540 EWIRYLLLGRVLRLTRILLQVQRFRAFVATFFTLMSSLMPYLGIVFCVLCMYCSIGLQIF 599
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
G++ A GN +L + +Y NF+D+ + +VTL+NL+V+ NWQV++++
Sbjct 600 GGIVYA--GNPTLEETD-------LFNNDYLLFNFNDYPSGMVTLFNLLVMGNWQVWMES 650
Query 662 YRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF-----LHKWDPRSHLQPLAGTPE 715
Y + +G WS IYFV ++L+S ++ +NL +A +LE F L K + P +G +
Sbjct 651 YWQLTGTSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQNPTSGGIK 710
Query 716 ATYQMTV 722
M V
Sbjct 711 KRRSMRV 717
>sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza
sativa subsp. japonica OX=39947 GN=TPC1 PE=1 SV=2
Length=757
Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust.
Identities = 125/455 (27%), Positives = 225/455 (49%), Gaps = 29/455 (6%)
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
T F + +L + +L TT+NNPDV +PAY +R ++FFIV+ ++G FL NL+ A+IY
Sbjct 271 TVFSSYGTTLYQMFILFTTSNNPDVWVPAYKSSRWSSLFFIVYVLLGVYFLTNLILAVIY 330
Query 313 SQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLD 372
F+ L K + + R+ AF ++ + G+G + L + +
Sbjct 331 DSFKEQLAKQVSQADCTRKSILEKAFGIIDA-TGQGYLNKEQCLSLLDELNKYRSLPKTS 389
Query 373 SSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR-----PE-YQSPFLQSAQ 426
+ + ++ G +++EEF L N + KE PP P Y S + +
Sbjct 390 REDFELIFAELDQSGDFKVTSEEFATLCNTIAIKFQKEPPPSYLEKYPSFYHSALCEWLK 449
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
F+Y+ + L NLV++ + LD + +++ + + VF Y++EM L
Sbjct 450 SFVRSPLFEYIVIFVLLMNLVAVIIETTLDIENSSSQK---VWQEVEFVFGWIYVIEMAL 506
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K+F+LG Y N FD +LT + + E T A P + LS + R
Sbjct 507 KIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAF---------PSKLSFLSNGEWIRY 557
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L + + R RI+ ++ +T L+ ++ + GI+ ++ +G+ +F G++
Sbjct 558 LLLGRMLRLTRILLQVRRFRAFVATFFTLMSSLMPYLGIVFCTLCIYCSLGLQIFGGIVY 617
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
A GN +L + + +Y NF+D+ + +VTL+NL+V+ NWQ ++++YR+ +
Sbjct 618 A--GNPTLEETDLFSN-------DYLLFNFNDYPSGMVTLFNLLVMGNWQAWMESYRQLT 668
Query 667 GP-WSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
G WS IYFV ++L+S ++ +NL +A +LE F +
Sbjct 669 GSYWSLIYFVSFYLISVLLLLNLIVAFVLEAFFAE 703
>sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus
norvegicus OX=10116 GN=Tpcn1 PE=1 SV=2
Length=817
Score = 153 bits (386), Expect = 3e-37, Method: Compositional matrix adjust.
Identities = 161/599 (27%), Positives = 271/599 (45%), Gaps = 68/599 (11%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRI 186
++E+ L+V +L +K G+ F ++ + VLVV ++ V L +R+
Sbjct 143 TLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSH-VRV 201
Query 187 RRLLRPFFLL--QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R LR FL+ + +++ L+ I SLP + LLL + +F + G LF+ D
Sbjct 202 TRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSD 261
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLM 304
YF L S+ +L VLLTTAN PDVM+P+YS+N +FFIV+ I F+M
Sbjct 262 --------PYFNTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIM 313
Query 305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGG-AFPQAVGVKPQNLL 363
NLL A+++ F ++ L +R + A+ +L S G ++ Q G L
Sbjct 314 NLLLAVVFDTFNDIEKHKFKSLLLHKRTAIQHAYHLLVSQRRPAGISYRQFEG------L 367
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHPPRP 415
K ++ + + + + + LLS ++F ++ + +R + PR
Sbjct 368 MRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKKNRQHWFDELPRT 427
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN-- 473
+ + L F Y L+ N V I V + + +FI +
Sbjct 428 AFL--IFKGINILVNSKAFQYFMYLVVAVNGVWILV------ETFMLKGGNFISKHVPWS 479
Query 474 -CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
VF+ Y +E+ +KV LG YLS N+FD +T
Sbjct 480 YLVFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAF--------------------- 518
Query 533 EMVGLLSLWDMTRMLNMLIVFR---FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+GLL+L ++V R LR+ K V T+ L+ M + G L+
Sbjct 519 AFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTF 578
Query 590 YYVFAIIGINLFRGVIVALPGNSS-LAPANG--SAPCGSFEQLE---YWANNFDDFAAAL 643
YY FAI+G+ F G + NSS +A A + G+ ++E Y+ NNFD+ +
Sbjct 579 YYSFAIVGMEFFSGRLSPNCCNSSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSF 638
Query 644 VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
VTL+ L VVNNW + ++ + WS++YF+ +++V+ V+ + + +A ILE F+ + +
Sbjct 639 VTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVV-MTIIVAFILEAFVFRMN 696
>sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus
musculus OX=10090 GN=Tpcn1 PE=1 SV=1
Length=817
Score = 152 bits (383), Expect = 8e-37, Method: Compositional matrix adjust.
Identities = 160/598 (27%), Positives = 271/598 (45%), Gaps = 66/598 (11%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRI 186
++E+ L+V +L +K G+ F ++ + VLVV ++ V L +R+
Sbjct 143 TLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSH-VRV 201
Query 187 RRLLRPFFLL--QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R LR FL+ + +++ L+ I SLP + LLL + +F + G LF+ D
Sbjct 202 TRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSD 261
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLM 304
YF L S+ +L VLLTTAN PDVM+P+YS+N +FFIV+ I F+M
Sbjct 262 P--------YFSTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIM 313
Query 305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGG-AFPQAVGVKPQNLL 363
NLL A+++ F ++ L +R + A+ +L+S G ++ Q G L
Sbjct 314 NLLLAVVFDTFNDIEKHKFKSLLLHKRTAIQHAYGLLASQRRPAGISYRQFEG------L 367
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHPPRP 415
K ++ + + + + + LLS ++F ++ + +R + PR
Sbjct 368 MRFYKPRMSARERFLTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRT 427
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICV--FLVLDADVLPAERDDFILGILN 473
+ + L F Y L+ N V I V F++ + L
Sbjct 428 AFL--IFKGINILVNSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKHVPWSYL---- 481
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
VF+ Y +E+ +KV LG YLS N+FD +T
Sbjct 482 -VFLTIYGVELFMKVAGLGPVEYLSSGWNLFDFSVTAFAF-------------------- 520
Query 534 MVGLLSLWDMTRMLNMLIVFR---FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
+GLL+L ++V R LR+ K V T+ L+ M + G L+ Y
Sbjct 521 -LGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFY 579
Query 591 YVFAIIGINLFRGVIVALPGN-SSLAPANG--SAPCGSFEQLE---YWANNFDDFAAALV 644
Y FAI+G+ F G + N S++A A + G+ ++E Y+ NNFD+ + V
Sbjct 580 YSFAIVGMEFFNGRLTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFV 639
Query 645 TLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
TL+ L VVNNW + ++ + WS++YF+ +++V+ V+ + + +A ILE F+ + +
Sbjct 640 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVV-MTIIVAFILEAFVFRMN 696
>sp|Q9ULQ1|TPC1_HUMAN Two pore channel protein 1 OS=Homo sapiens
OX=9606 GN=TPCN1 PE=1 SV=3
Length=816
Score = 148 bits (374), Expect = 1e-35, Method: Compositional matrix adjust.
Identities = 158/598 (26%), Positives = 276/598 (46%), Gaps = 66/598 (11%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLR 185
++E+ L+V +L +K G F ++ + VLVV V+ V L + H +R
Sbjct 142 TLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSH--VR 199
Query 186 IRRLLRPFFLL--QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
+ R LR FL+ + +++ L+ I SLP + LLL + +F + G LF+
Sbjct 200 VTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPS 259
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
D YF L S+ SL VLLTTAN PDVM+P+YS+N +FFIV+ I F+
Sbjct 260 D--------PYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFI 311
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
MNLL A+++ F + ++ L +R + A+ +L S P + + L
Sbjct 312 MNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRR-----PAGISYRQFEGL 366
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
K ++ + + + + + LLS ++F ++ E+ K R + +
Sbjct 367 MRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIY-EVAALKWKAKKNREHWFDELPR 425
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN---------- 473
+A +F N++ + ++LV+ + + + F+L N
Sbjct 426 TALLIFKGI------NILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSY 479
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
VF+ Y +E+ LKV LG YLS N+FD +TV + ++ P
Sbjct 480 LVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL-------NMEP- 531
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV---VASTVLGLVQNMRAFGGILVVVY 590
++V R L+++ KL V T+ L+ M + G L++ Y
Sbjct 532 -------------FYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY 578
Query 591 YVFAIIGINLFRGVIVALPGN-SSLAPA----NGSAPCGS-FEQLEYWANNFDDFAAALV 644
Y FAI+G+ F G++ N S++A A N + + E+ Y+ NNFD+ + V
Sbjct 579 YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV 638
Query 645 TLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
TL+ L VVNNW + ++ + WS++YF+ +++V+ V+ + + +A ILE F+ + +
Sbjct 639 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVV-MTIIVAFILEAFVFRMN 695
>sp|O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Homo sapiens OX=9606 GN=CACNA1H PE=1 SV=4
Length=2353
Score = 82.8 bits (203), Expect = 8e-15, Method: Compositional matrix adjust.
Identities = 67/234 (29%), Positives = 114/234 (49%), Gaps = 35/234 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I N VF + LEMLLK+ A G GY+ P N+FDG++ VV+ V EI A
Sbjct 825 LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGII-VVISVWEIVGQA------- 876
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G LS+ R+L +L + RFL P+++ VV ++ + N+ F +L++
Sbjct 877 ------DGGLSVLRTFRLLRVLKLVRFL---PALRRQLVV---LVKTMDNVATFCTLLML 924
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++F+I+G++LF G +L ++ + NFD A+VT++
Sbjct 925 FIFIFSILGMHLF-GCKFSLKTDTGDTVPD--------------RKNFDSLLWAIVTVFQ 969
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
++ +W V L + W+ +YFV + + NL +A+++E F + D
Sbjct 970 ILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGD 1023
Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 77/301 (26%), Positives = 136/301 (45%), Gaps = 38/301 (13%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD-ADVLPAERDDFILGILNCVF 476
Q+ F S Q + H FD+ + L + CV + L+ D+ P + L + N +F
Sbjct 1280 QNRFRVSCQKVITHKMFDH----VVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIF 1335
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
++ EM++KV ALGL YL N+ DGLL +V LV + +A
Sbjct 1336 TAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASA--------- 1386
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV--- 589
+L + + R+L L R + P +KL+ V L+ ++R G I+++
Sbjct 1387 GGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV------VETLISSLRPIGNIVLICCAF 1440
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+ +F I+G+ LF+G G + + + + + NFD+ AL++L+ L
Sbjct 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500
Query 650 MVVNNW-QVFLDAYR---------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + D + PW +YF+ + L+ S +N+F+ +++ENF H
Sbjct 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-H 1559
Query 700 K 700
K
Sbjct 1560 K 1560
Score = 47.8 bits (112), Expect = 5e-04, Method: Compositional matrix adjust.
Identities = 71/289 (25%), Positives = 117/289 (40%), Gaps = 51/289 (18%)
Query 413 PRPEYQ--------SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
P PE Q SP +S L +Y D I N++++ + L
Sbjct 1590 PSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSL---- 1645
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
D L N VF + ++ E LK+ A G R + N D L +VLL L TL
Sbjct 1646 -DEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLD--LAIVLLSLMGITLEEI- 1701
Query 525 LPHPGWRPEMVGLLSL-WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
EM L + + R++ +L + R L+++ M + TV+ + + G
Sbjct 1702 --------EMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLG 1753
Query 584 GILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
+ +++++++A +G+ LF G + N PC E L A F +F A
Sbjct 1754 LLFMLLFFIYAALGVELF--------GRLECSEDN---PC---EGLSRHAT-FSNFGMAF 1798
Query 644 VTLWNLMVVNNWQ-VFLDAYRR----------YSGPWSKIYFVLWWLVS 681
+TL+ + +NW + D R Y S +YFV + LV+
Sbjct 1799 LTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVA 1847
Score = 38.5 bits (88), Expect = 0.34, Method: Compositional matrix adjust.
Identities = 52/219 (24%), Positives = 102/219 (47%), Gaps = 24/219 (11%)
Query 111 VRYRAAPWEPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLL--GYLVVL 165
V Y P E LT ++E+ ++ +FA ++ +K G + +N + + G +VV+
Sbjct 812 VEYHEQPEE----LTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVI 867
Query 166 ----VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGL 221
+V D +S+ LR RLLR L++ +++ L + ++ +A+
Sbjct 868 SVWEIVGQADGGLSV-------LRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCT 920
Query 222 LLAIHLCLFTMFGMLLFAGG---KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
LL + + +F++ GM LF K D G F +L ++ ++ +LT + V+
Sbjct 921 LLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 980
Query 279 IPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++A ++F+ G+ L NLL AI+ F+
Sbjct 981 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
>sp|Q9EQ60|CAC1H_RAT Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Rattus norvegicus OX=10116 GN=Cacna1h PE=2
SV=2
Length=2359
Score = 82.4 bits (202), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 68/234 (29%), Positives = 114/234 (49%), Gaps = 35/234 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I N VF + LEMLLK+ A G GY+ P N+FDG++ VV+ V EI A
Sbjct 822 LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIV-VVISVWEIVGQA------- 873
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G LS+ R+L +L + RFL P+++ VV ++ + N+ F +L++
Sbjct 874 ------NGGLSVLRTFRLLRVLKLVRFL---PALRRQLVV---LMRTMDNVATFCMLLML 921
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++F+I+G++LF G +L +S + NFD A+VT++
Sbjct 922 FIFIFSILGMHLF-GCKFSLKTDSGDTVPD--------------RKNFDSLLWAIVTVFQ 966
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
++ +W V L + W+ +YFV + + NL +A+++E F + D
Sbjct 967 ILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGD 1020
Score = 76.6 bits (187), Expect = 7e-13, Method: Compositional matrix adjust.
Identities = 76/295 (26%), Positives = 133/295 (45%), Gaps = 38/295 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLD-ADVLPAERDDFILGILNCVFIVYYLL 482
S Q + H FD+ + L + C+ + L+ D+ P + L + N +F +++
Sbjct 1297 SCQKVIAHKMFDH----VVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVV 1352
Query 483 EMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
EM++KV ALGL YL NV DGLL +V LV I +A +L
Sbjct 1353 EMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAMASA---------GGAKIL 1403
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAI 595
+ + R+L L R + P +KL+ V L+ ++R G I+++ + +F I
Sbjct 1404 GVLRVLRLLRTLRPLRVISRAPGLKLV------VETLISSLRPIGNIVLICCAFFIIFGI 1457
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
+G+ LF+G G + + + + NFD+ AL++L+ L + W
Sbjct 1458 LGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGW 1517
Query 656 -QVFLDAYR---------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ D + PW +YF+ + L+ S +N+F+ +++ENF HK
Sbjct 1518 VNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-HK 1571
Score = 41.2 bits (95), Expect = 0.051, Method: Compositional matrix adjust.
Identities = 61/271 (23%), Positives = 113/271 (42%), Gaps = 43/271 (16%)
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+S L +Y D I N++++ + L D L N VF + ++
Sbjct 1613 RSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSL-----DEALKYCNYVFTIVFVF 1667
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLW- 541
E LK+ A G R + N D + +++L I +A+ + EM L +
Sbjct 1668 EAALKLVAFGFRRFFKDRWNQLD----LAIVLLSIMGIALEEI-------EMNAALPINP 1716
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R++ +L + R L+++ M + TV+ + + G + +++++++A +G+ LF
Sbjct 1717 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1776
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLD 660
G + N PC E L A F +F A +TL+ + +NW + D
Sbjct 1777 --------GRLECSEDN---PC---EGLSRHAT-FTNFGMAFLTLFRVSTGDNWNGIMKD 1821
Query 661 AYRR----------YSGPWSKIYFVLWWLVS 681
R Y S +YFV + LV+
Sbjct 1822 TLRECTREDKHCLSYLPALSPVYFVTFMLVA 1852
Score = 40.0 bits (92), Expect = 0.10, Method: Compositional matrix adjust.
Identities = 52/219 (24%), Positives = 104/219 (47%), Gaps = 24/219 (11%)
Query 111 VRYRAAPWEPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVV 167
V Y P E LT ++E+ ++ +FA ++ +K G + +N + + +V+V+
Sbjct 809 VEYHEQPEE----LTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVI 864
Query 168 SLVDWTV------SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGL 221
S+ W + LS+ LR RLLR L++ +++ L + ++ +A+ +
Sbjct 865 SV--WEIVGQANGGLSV-----LRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCM 917
Query 222 LLAIHLCLFTMFGMLLFAGG---KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
LL + + +F++ GM LF K D G F +L ++ ++ +LT + V+
Sbjct 918 LLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 977
Query 279 IPAYSKNRAYA-IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++A ++F+ G+ L NLL AI+ F+
Sbjct 978 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1016
>sp|Q9R053|SCNBA_MOUSE Sodium channel protein type 11 subunit
alpha OS=Mus musculus OX=10090 GN=Scn11a PE=1 SV=2
Length=1765
Score = 82.4 bits (202), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 130/589 (22%), Positives = 246/589 (42%), Gaps = 104/589 (18%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+F ++ +K FG+ + + W +++VVS + T +L + R R LRP
Sbjct 1078 FIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSLT---NLPNLKSFRNLRALRPL 1134
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--GKQDDGQDRER 251
L MK + + ++P + +V L+ I +F + G+ F+G G+ +G D +
Sbjct 1135 RALSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINK 1194
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
N+P L+ N + + + F +G+ +L L A
Sbjct 1195 YFNASNVPNQSQCLV-----------------SNYTWKVPNVNFDNVGNAYLALLQVAT- 1236
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQNL 362
++G+L + ++ R + AFE V+ + G +GV N
Sbjct 1237 ---YKGWL-DIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNF 1292
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
Q +K+ G + EE +K +N + + K+ P+ P
Sbjct 1293 NQQQKKLG----------------GQDIFMTEEQKKYYNAMKKLGTKK--PQKPIPRPLN 1334
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+ F+F + ++I L +V+ + ++ +++ P E I ILN VF+V + +
Sbjct 1335 KCQAFVF-DLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKK-IFDILNIVFVVIFTV 1392
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-WRPEMVGLLSLW 541
E L+KVFAL + Y + N+FD V++VL I + V L + + P + ++ L
Sbjct 1393 ECLIKVFALR-QHYFTNGWNLFD----CVVVVLSIISTLVSGLENSNVFPPTLFRIVRLA 1447
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ R +R + +M++ + +GL +L +V +++AI G+N F
Sbjct 1448 RIGRILRLVRAARGIRTLLFALMMSLPSLFNIGL---------LLFLVMFIYAIFGMNWF 1498
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
V GS F NFD F+ +++ L+ + W L+
Sbjct 1499 SKV------------KRGSGIDDIF--------NFDTFSGSMLCLFQITTSAGWDALLNP 1538
Query 662 YRRYSGPWSK-------------IYFVLWWLVSSVIWVNLFLALILENF 697
+ +YFV + ++S +I VN+++A+ILENF
Sbjct 1539 MLESKASCNSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILENF 1587
Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 66/284 (23%), Positives = 122/284 (43%), Gaps = 55/284 (19%)
Query 447 VSIC-----VFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS 501
++IC VFL ++ + D IL I N VF ++ EM LK+ AL Y +
Sbjct 581 ITICIIVNTVFLAMEHHNMDNSLKD-ILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGW 639
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPS 561
N+FD ++ +V L + + ++L LS R+L VF+ + P+
Sbjct 640 NIFDSIVALVSL----ADVLFHKLSKN---------LSFLASLRVLR---VFKLAKSWPT 683
Query 562 MKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
+ + + +G + N+ +L +V ++F+++G+ LF S +P
Sbjct 684 LNTLIKIIGHSVGALGNLTV---VLTIVVFIFSVVGMRLFGA---KFNKTCSTSP----- 732
Query 622 PCGSFEQLEYWANNFDDFAAALVTLWNLM----VVNNWQVFLDAYRRYSGPWSKIYFVLW 677
E L W + DF + + ++ ++ + N W+ + P I FVL
Sbjct 733 -----ESLRRW--HMGDFYHSFLVVFRILCGEWIENMWECMQEM---EGSPLCVIVFVLI 782
Query 678 WLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMT 721
+V ++ +NLF+AL+L +F + + G PE + T
Sbjct 783 MVVGKLVVLNLFIALLLNSFSN--------EEKDGNPEGETRKT 818
Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 55/247 (22%), Positives = 97/247 (39%), Gaps = 39/247 (16%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + +F +LLEM+LK A G R Y + D L+ VV S L++ LP+
Sbjct 1068 LLKCTDNIFTFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVV------SGLSLTNLPN 1121
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ L R LR + + M VV + ++ + + + +
Sbjct 1122 ----------------LKSFRNLRALRPLRALSQFEGMKVVVNALMSAIPAILNVLLVCL 1165
Query 588 VVYYVFAIIGINLFRG----VIVALPGNSSLAPANGSAPCGSFEQLEYWA---NNFDDFA 640
+ + +F I+G+N F G I N +N W NFD+
Sbjct 1166 IFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQCLVSNYTWKVPNVNFDNVG 1225
Query 641 AALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFL 690
A + L + W ++A G ++ +YFV++ + S +NLF+
Sbjct 1226 NAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIFGSFFTLNLFI 1285
Query 691 ALILENF 697
+I++NF
Sbjct 1286 GVIIDNF 1292
Score = 36.6 bits (83), Expect = 1.0, Method: Compositional matrix adjust.
Identities = 53/256 (21%), Positives = 102/256 (40%), Gaps = 59/256 (23%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VFI Y+LE ++K+ A G YL P N D +V+ + +
Sbjct 164 VFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLD------FIVIGTAIAPCF------- 210
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
L + L+ L FR LR + ++ +++ + V L+++++ ++V+
Sbjct 211 ---------LGNKVNNLSTLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTL 261
Query 591 Y---VFAIIGINLFRGVIV-----------ALPGNSSLAPANGSAP---CGSFE------ 627
+ +FA++G LF G++ A N S CG++
Sbjct 262 FCLSIFALVGQQLFMGILSQKCIKDDCGPNAFSNKDCFVKENDSEDFIMCGNWLGRRSCP 321
Query 628 ----------QLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLW 677
+Y NFD F + + ++ +M ++W+ R SG + +FV+
Sbjct 322 DGSTCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVV 381
Query 678 WLVSSVIWVNLFLALI 693
+ S +NL LA++
Sbjct 382 IFLGSFYLLNLTLAVV 397
>sp|O88427|CAC1H_MOUSE Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Mus musculus OX=10090 GN=Cacna1h PE=1
SV=3
Length=2365
Score = 82.0 bits (201), Expect = 1e-14, Method: Compositional matrix adjust.
Identities = 67/234 (29%), Positives = 114/234 (49%), Gaps = 35/234 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I N VF + LEMLLK+ A G GY+ P N+FDG++ V++ V EI A
Sbjct 822 LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIV-VIISVWEIVGQA------- 873
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G LS+ R+L +L + RFL P+++ VV ++ + N+ F +L++
Sbjct 874 ------DGGLSVLRTFRLLRVLKLVRFL---PALRRQLVV---LMRTMDNVATFCMLLML 921
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++F+I+G++LF G +L +S + NFD A+VT++
Sbjct 922 FIFIFSILGMHLF-GCKFSLKTDSGDTVPD--------------RKNFDSLLWAIVTVFQ 966
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
++ +W V L + W+ +YFV + + NL +A+++E F + D
Sbjct 967 ILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGD 1020
Score = 75.9 bits (185), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 76/295 (26%), Positives = 133/295 (45%), Gaps = 38/295 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLD-ADVLPAERDDFILGILNCVFIVYYLL 482
S Q + H FD+ + L + C+ + L+ D+ P + L + N +F +++
Sbjct 1297 SCQKVIAHKMFDH----VVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVV 1352
Query 483 EMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
EM++KV ALGL YL NV DGLL +V LV I +A +L
Sbjct 1353 EMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAVASA---------GGAKIL 1403
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAI 595
+ + R+L L R + P +KL+ V L+ ++R G I+++ + +F I
Sbjct 1404 GVLRVLRLLRTLRPLRVISRAPGLKLV------VETLISSLRPIGNIVLICCAFFIIFGI 1457
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
+G+ LF+G G + + + + NFD+ AL++L+ L + W
Sbjct 1458 LGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGW 1517
Query 656 -QVFLDAYR---------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ D + PW +YF+ + L+ S +N+F+ +++ENF HK
Sbjct 1518 VNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-HK 1571
Score = 41.6 bits (96), Expect = 0.035, Method: Compositional matrix adjust.
Identities = 66/289 (23%), Positives = 118/289 (41%), Gaps = 51/289 (18%)
Query 413 PRPEYQ--------SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
P PE Q S +S L +Y D I N++++ + L
Sbjct 1601 PNPEAQRRPYYADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSL---- 1656
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
D L N VF + ++ E LK+ A G R + N D + +++L I +A+
Sbjct 1657 -DEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLD----LAIVLLSIMGIALEE 1711
Query 525 LPHPGWRPEMVGLLSL-WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
+ EM L + + R++ +L + R L+++ M + TV+ + + G
Sbjct 1712 I-------EMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLG 1764
Query 584 GILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
+ +++++++A +G+ LF G + N PC E L A F +F A
Sbjct 1765 LLFMLLFFIYAALGVELF--------GRLECSEDN---PC---EGLSRHAT-FTNFGMAF 1809
Query 644 VTLWNLMVVNNWQ-VFLDAYRR----------YSGPWSKIYFVLWWLVS 681
+TL+ + +NW + D R Y S +YFV + LV+
Sbjct 1810 LTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPALSPVYFVTFVLVA 1858
Score = 39.3 bits (90), Expect = 0.19, Method: Compositional matrix adjust.
Identities = 49/212 (23%), Positives = 102/212 (48%), Gaps = 20/212 (9%)
Query 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
E P LT ++E+ ++ +FA ++ +K G + +N + + +V+++S+ W +
Sbjct 813 EQPDELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVIISV--WEIV 870
Query 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
LS+ LR RLLR L++ +++ L + ++ +A+ +LL + + +
Sbjct 871 GQADGGLSV-----LRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFI 925
Query 230 FTMFGMLLFAGG---KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
F++ GM LF K D G F +L ++ ++ +LT + V+ +
Sbjct 926 FSILGMHLFGCKFSLKTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS 985
Query 287 AYA-IFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
++A ++F+ G+ L NLL AI+ F+
Sbjct 986 SWAALYFVALMTFGNYVLFNLLVAILVEGFQA 1017
>sp|Q24270|CAC1D_DROME Voltage-dependent calcium channel type
D subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=Ca-alpha1D
PE=1 SV=2
Length=2516
Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust.
Identities = 136/636 (21%), Positives = 264/636 (42%), Gaps = 134/636 (21%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE + L++F A+ +K G++ + +N W L ++V+ + + +LS +
Sbjct 651 EKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAI--STALSQLMK 708
Query 182 EP-----LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+
Sbjct 709 DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLE 768
Query 237 LFAGGKQDDGQDR--------------------------------ERLTYFQNLPESLTS 264
LF+G +D + +T F N ++ +
Sbjct 769 LFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLT 828
Query 265 LLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ +T DV+ YS A ++FI ++G+ F+MNL+ ++ +F
Sbjct 829 VFQCVTLEGWTDVL---YSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKER 885
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
K+ F++ R ++ + G QA ++P + ++ D KQ
Sbjct 886 NKAKNRGDFQK---LREKQQIEEDLRGYLDWITQAEDIEPDAVGGLIS----DGKGKQPN 938
Query 380 -MEKVRSYGS----VLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYF 434
M+ + G V ++ ++K+ + DR V R ++ Q+ +L
Sbjct 939 EMDSTENLGEEMPEVQMTESRWRKMKKDFDR--VNRRMRRACRKAVKSQAFYWL------ 990
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAER-------DDFILGILNCVFIVYYLLEMLLK 487
I V + L+ VL E D+F N FI + EMLLK
Sbjct 991 --------------IIVLVFLNTGVLATEHYGQLDWLDNF-QEYTNVFFIGLFTCEMLLK 1035
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+++LG +GY N FD + I ++ L + G P + +S+ R+L
Sbjct 1036 MYSLGFQGYFVSLFNRFDCFVV-------IGSITETLLTNTGMMPPLG--VSVLRCVRLL 1086
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
+ V ++ R L +VAS +L +Q++ + +L + +FA++G+ +F G
Sbjct 1087 RVFKVTKYWR-----SLSNLVAS-LLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF-- 1138
Query 608 LPGNSSLAPANGSAPCGSFE-QLEYWANNFDDFAAALVTLWNLMVVNNWQ----VFLDAY 662
+F+ + E + NFD F AL+T++ +M +W V ++AY
Sbjct 1139 -----------------NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAY 1181
Query 663 RRYS--GPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
S G + IYF++ ++ + I +N+FLA+ ++N
Sbjct 1182 GGVSSYGALACIYFIILFICGNYILLNVFLAIAVDN 1217
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 56/258 (22%), Positives = 113/258 (44%), Gaps = 50/258 (19%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVY 523
+L LN +F + LE + K+ A + Y NVFD ++ + ++ EI +
Sbjct 1694 LLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTS 1753
Query 524 RLPHPGWRPEMVGLLSLWDMTRMLNMLIV--FRFLRIIPSMKLMAVVAS------TVLGL 575
++ ++V + N++ + FR R++ +KL++ T +
Sbjct 1754 QIAEC----DIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKS 1809
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
Q + ++V++++++A++G+ +F + AL G +++ AN NN
Sbjct 1810 FQALPYVALLIVLLFFIYAVVGMQVFGKI--ALDGGNAIT-AN---------------NN 1851
Query 636 FDDFAAALVTLWNLMVVNNWQ-----------VFLDAYRRYSGP--WSKI---YFVLWWL 679
F F A++ L+ WQ V D G S I YF+ +++
Sbjct 1852 FQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYV 1911
Query 680 VSSVIWVNLFLALILENF 697
+ S + +NLF+A+I++NF
Sbjct 1912 LCSFLIINLFVAVIMDNF 1929
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 35/141 (25%), Positives = 61/141 (43%), Gaps = 18/141 (13%)
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
++L +L V R LR I K + V V+ V+ + + ++ ++FA+IG+ LF+G
Sbjct 1439 KILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGK 1498
Query 605 IVALPGNSSLAP----------ANGSAPCGSFEQLEYWANN---FDDFAAALVTLWNLMV 651
S + +G + E W+NN FDD A ++TL+ +
Sbjct 1499 FFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLRERE-WSNNRFHFDDVAKGMLTLFTVST 1557
Query 652 VNNWQ----VFLDAYRRYSGP 668
W V +D+ + GP
Sbjct 1558 FEGWPGLLYVSIDSNKENGGP 1578
Score = 42.7 bits (99), Expect = 0.015, Method: Compositional matrix adjust.
Identities = 63/300 (21%), Positives = 130/300 (43%), Gaps = 42/300 (14%)
Query 434 FDYLGNLIALANLVSICVFLVL---DADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
F++L L AN +++ V+ D++V + L + VF+V + E ++K+ A
Sbjct 617 FEFLILLTIFANCIALAVYTPYPGSDSNVT-----NQTLEKVEYVFLVIFTAECVMKILA 671
Query 491 LGLRGYLSYPSNVFDG--LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
G L + + +G LL ++V+ + A+ +L + +D+ + L
Sbjct 672 YGF--VLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-----------MKDAFDV-KALR 717
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI--- 605
V R LR++ + + VV +++L + + +++ V ++AIIG+ LF G +
Sbjct 718 AFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKA 777
Query 606 ----VALPGNSSLAPANGSAPC-------GSFEQLEYWANNFDDFAAALVTLWNLMVVNN 654
+ ++ P C G ++ NFD+F A++T++ + +
Sbjct 778 CRDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEG 837
Query 655 WQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPRSHLQPL 710
W L + + G W +YF+ ++ + +NL L ++ F +K R Q L
Sbjct 838 WTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKL 897
>sp|Q25452|CAC1M_MUSDO Muscle calcium channel subunit alpha-1
OS=Musca domestica OX=7370 PE=2 SV=1
Length=1687
Score = 78.2 bits (191), Expect = 2e-13, Method: Compositional matrix adjust.
Identities = 127/645 (20%), Positives = 256/645 (40%), Gaps = 149/645 (23%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E +E + L++F ++ +K G++ + +N W ++V+ ++ + +LS +
Sbjct 97 EKIEYIFLVIFTSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMI--STALSNLVK 154
Query 182 E-----PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
E LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+
Sbjct 155 EGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLE 214
Query 237 LFAG-----------GKQDDGQDR------------------------ERLTYFQNLPES 261
LF+G G+ + D + +T F N S
Sbjct 215 LFSGKLHKTCRHSNTGEYLNDLDELHACGVGFKCPSGYECFDDWVGPNDGITNFDNFGLS 274
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ YS A I+F+ ++G+ F+MNL+ ++ +F
Sbjct 275 MLTVFQCITLEGWTDVL---YSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFS 331
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA ++P Q+++ HK
Sbjct 332 KERTKAKNRGDFQK---LREKQQIEEDLRGYLDWITQAEDIEPDPDAQIIE-----DCHK 383
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
+ E V +D +K+H + + +S + Y +
Sbjct 384 NKVKEVV------------------SIDN--LKDHENETQQTDSWFRSQK-----KYLER 418
Query 437 LGNLIALANLVS---------ICVFLVLDADVLPAER-------DDFILGILNCVFIVYY 480
+ I A + I + + L+ VL E D F N FI +
Sbjct 419 INRRIRRACRKAVKSQAFYWLIILLVFLNTGVLATEHYRQPIWLDQF-QEYTNIFFIALF 477
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
EM+LK+++LG +GY N FD + + G EMV S
Sbjct 478 TCEMILKMYSLGFQGYFVSLFNRFDCFVVI------------------GSISEMVLTSSE 519
Query 541 WDMTRMLNMLIVFRFLRIIPSMKL---MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+++L R LR+ K ++ + +++L +Q++ + +L + +F ++G
Sbjct 520 LMAPLGVSVLRCVRLLRVFKVTKYWHSLSNLVASLLNSIQSIASLLLLLFLFIVIFGLLG 579
Query 598 INLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
+ +F G P + E +NFD F +L+T++ ++ +W V
Sbjct 580 MQVFGGRFTFKP------------------EEEKPRSNFDSFYQSLLTVFQILTGEDWNV 621
Query 658 FL-DAYRRYSGPWS-----KIYFVLWWLVSSVIWVNLFLALILEN 696
+ D R Y G +S IY+++ ++ + I +N+FLA+ ++N
Sbjct 622 VMYDGIRAYGGVFSFGIVACIYYIILFICGNYILLNVFLAIAVDN 666
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 148/713 (21%), Positives = 279/713 (39%), Gaps = 114/713 (16%)
Query 21 DWPAGLTTYRSIQVGPGAAARWDLCIDQA--VVFIEDAIQYRSINHRVDA----SSMWLY 74
DW +T I+ P A D ++ VV I++ + + + D+ +L
Sbjct 361 DW---ITQAEDIEPDPDAQIIEDCHKNKVKEVVSIDNLKDHENETQQTDSWFRSQKKYLE 417
Query 75 R--RYYSNVCQRTLSFTIF--LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEV 130
R R C++ + F LI+ L F+ T T YR W E +
Sbjct 418 RINRRIRRACRKAVKSQAFYWLIILLVFLNTGVLATE----HYRQPIWLDQ--FQEYTNI 471
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH----EPLRI 186
+ +F ++ +K Y G+ + +L+ V++ S+ + ++ S + LR
Sbjct 472 FFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIGSISEMVLTSSELMAPLGVSVLRC 531
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
RLLR F + + + + + S+ +AS+ LLL + + +F + GM +F G
Sbjct 532 VRLLRVFKVTKYWHSLSNLVASLLNSIQSIASLLLLLFLFIVIFGLLGMQVFGGRFTFKP 591
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA----------IFFIVFT 296
++ + + F + +SL ++ +LT D + Y RAY I++I+
Sbjct 592 EEEKPRSNFDSFYQSLLTVFQILT---GEDWNVVMYDGIRAYGGVFSFGIVACIYYIILF 648
Query 297 VIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV-------GEGG 349
+ G+ L+N+ AI SL T + ++ + M G+
Sbjct 649 ICGNYILLNVFLAIAVDNLAD--ADSLSTIEKEDESQIQLDNQIKNEMENEEYLQNGDHI 706
Query 350 AFPQAVGVKPQNLLQVLQKVQLDS-SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+F G +L LQ + S S + K+ G V + D +
Sbjct 707 SFKAEFGA---DLDTYLQDEECGSYSDDENTYNKL---GGVKQRVSSLPRRNTNTDMDRI 760
Query 409 KEHPPRPEYQSPFLQSAQFLFGHY-----YFDYLGNLIALANLVSICVFLVLDADVLPAE 463
K+ P Y + F F+F H + L N N + C+ + + +L AE
Sbjct 761 KKDIP---YGTSF-----FIFSHTNRFRIFCHRLCNHSNFGNFILCCI--MFSSAMLAAE 810
Query 464 R-------DDFILGILNCVFIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVL 512
+ +L + F + +E++LK+ + G + N+ D L
Sbjct 811 NPLKADASRNIVLNKFDYFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLD------L 864
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
LV+ +S ++++ + + ++ ++L +L V R LR I K + V V
Sbjct 865 LVVCVSLISIF------FNSNAISVV------KILRVLRVLRPLRAINRAKGLKHVVQCV 912
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA----------NGSAP 622
+ V+ + + ++ ++FA+IG+ LF+G + S + + NG
Sbjct 913 IVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFSCSDGSKVYESDCHGTYLFYENGDIN 972
Query 623 CGSFEQLEYWANN---FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
++ E W NN FDD A A++TL+ + W L D+ + GP
Sbjct 973 KPRLKERE-WKNNKFHFDDVAKAMLTLFTVSTFEGWPTLLYVSIDSNKENGGP 1024
Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 68/302 (23%), Positives = 130/302 (43%), Gaps = 43/302 (14%)
Query 434 FDYLGNLIALANLVSICVFLVL---DADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
F+Y L AN V++ V+ D+++ +L + +F+V + E ++K+ A
Sbjct 63 FEYFILLTIFANCVALAVYTPYPSGDSNITNQ-----MLEKIEYIFLVIFTSECVMKIIA 117
Query 491 LGLRGYL-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
G + SY N ++ L ++++ IST A+ L G+ + L
Sbjct 118 YGFVLHTGSYLRNGWNFLDFFIVVIGMIST-ALSNLVKEGFD------------VKALRA 164
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
V R LR++ + + VV +++L + + +++ V ++AIIG+ LF G +
Sbjct 165 FRVLRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTC 224
Query 610 GNSS----LAPANGSAPCG-------SFEQLEYWA------NNFDDFAAALVTLWNLMVV 652
+S+ L + CG +E + W NFD+F +++T++ + +
Sbjct 225 RHSNTGEYLNDLDELHACGVGFKCPSGYECFDDWVGPNDGITNFDNFGLSMLTVFQCITL 284
Query 653 NNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLH---KWDPRSHLQ 708
W L + + G W IYFV ++ + +NL L ++ F K R Q
Sbjct 285 EGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFSKERTKAKNRGDFQ 344
Query 709 PL 710
L
Sbjct 345 KL 346
Score = 46.6 bits (109), Expect = 9e-04, Method: Compositional matrix adjust.
Identities = 52/249 (21%), Positives = 100/249 (40%), Gaps = 37/249 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVY 523
IL LN +F + LE + K+ A + Y N FD ++ + ++ EI T
Sbjct 1140 ILDALNMIFTAVFSLEFIFKLAAFRFKNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQA 1199
Query 524 RLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
G S + V R ++++ + + + T + Q +
Sbjct 1200 LATCDGQSCNKAKGGSTLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVA 1259
Query 584 GILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
++V++++++A+IG+ +F G I+ G S N NNF F A+
Sbjct 1260 LLIVMLFFIYAVIGMQVF-GKIMLEEGTS--IDRN---------------NNFQTFPQAV 1301
Query 644 VTLWNLMVVNNWQVFL---------------DAYRRYSGPWSKIYFVLWWLVSSVIWVNL 688
+ L+ WQ + DA + YF+ ++++ S + +NL
Sbjct 1302 LVLFRSATGEAWQEIMMACSPRDDVKCDPESDAVNNCGSSIAFPYFISFYVLCSFLIINL 1361
Query 689 FLALILENF 697
F+A+I++NF
Sbjct 1362 FVAVIMDNF 1370
Score = 35.8 bits (81), Expect = 2.1, Method: Compositional matrix adjust.
Identities = 36/155 (23%), Positives = 65/155 (42%), Gaps = 17/155 (11%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
R+ R++R LL ++ L S + V LL+ + ++ + GM +F
Sbjct 1223 FRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIML 1282
Query 244 DDGQDRERLTYFQNLPESLTSLL----------VLLTTANNPDVMIPAYS---KNRAYAI 290
++G +R FQ P+++ L +++ + DV S N +I
Sbjct 1283 EEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDDVKCDPESDAVNNCGSSI 1342
Query 291 ---FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+FI F V+ S ++NL A+I F YL +
Sbjct 1343 AFPYFISFYVLCSFLIINLFVAVIMDNF-DYLTRD 1376
>sp|O54898|CAC1G_RAT Voltage-dependent T-type calcium channel
subunit alpha-1G OS=Rattus norvegicus OX=10116 GN=Cacna1g PE=1
SV=2
Length=2254
Score = 77.4 bits (189), Expect = 4e-13, Method: Compositional matrix adjust.
Identities = 71/267 (27%), Positives = 125/267 (47%), Gaps = 38/267 (14%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
Y G I +A LV+ + + ++ P E + L I N VF + LEMLLK+ G G
Sbjct 745 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 802
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y+ P N+FDG++ VV+ V EI + G LS+ R++ +L + RF
Sbjct 803 YIKNPYNIFDGVI-VVISVWEIVG-------------QQGGGLSVLRTFRLMRVLKLVRF 848
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
L P+++ VV ++ + N+ F +L++ ++F+I+G++LF G A +
Sbjct 849 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 901
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
P NFD A+VT++ ++ +W L + W+ +YF+
Sbjct 902 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 946
Query 676 LWWLVSSVIWVNLFLALILENFLHKWD 702
+ + NL +A+++E F + D
Sbjct 947 ALMTFGNYVLFNLLVAILVEGFQAEGD 973
Score = 66.2 bits (160), Expect = 9e-10, Method: Compositional matrix adjust.
Identities = 75/300 (25%), Positives = 134/300 (45%), Gaps = 36/300 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
QS F + H FD++ +I N ++I + + P + L + N +F
Sbjct 1241 QSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAM---ERPKIDPHSAERIFLTLSNYIFT 1297
Query 478 VYYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+L EM +KV ALG + YL NV DGLL ++ ++ + V + G +
Sbjct 1298 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK-- 1351
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---Y 590
+ M R+L +L R LR+I + + +V T L+ +++ G I+V+ +
Sbjct 1352 ------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAFF 1402
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+F I+G+ LF+G G + N S + + NFD+ AL++L+ L
Sbjct 1403 IIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLA 1462
Query 651 VVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ W + D PW +YF+ + L+ + +N+F+ +++ENF HK
Sbjct 1463 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-HK 1521
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 67/278 (24%), Positives = 125/278 (45%), Gaps = 45/278 (16%)
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
HY ++ +I L N+V++ + +L D L I N +F V ++ E + K+ A
Sbjct 1579 HYLDLFITGVIGL-NVVTMAMEHYQQPQIL-----DEALKICNYIFTVIFVFESVFKLVA 1632
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
G R + N D L +VLL + TL E+ LSL ++ ++
Sbjct 1633 FGFRRFFQDRWNQLD--LAIVLLSIMGITLE-----------EIEVNLSLPINPTIIRIM 1679
Query 551 IVFRFLRIIPSMKL---MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
V R R++ +K+ M + TV+ + + G + ++++++FA +G+ LF +
Sbjct 1680 RVLRIARVLKLLKMAVGMRALLHTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL--- 1736
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-- 664
+ + PC E L A F +F A +TL+ + +NW + D R
Sbjct 1737 --------ECDETHPC---EGLGRHA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCD 1784
Query 665 -----YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y+ S IYFV + L + + VN+ +A+++++
Sbjct 1785 QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1822
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 50/211 (24%), Positives = 104/211 (49%), Gaps = 19/211 (9%)
Query 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
E P LT ++E+ ++ +FA ++ +K ++G + KN + + V++V+S+ W +
Sbjct 767 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 824
Query 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
LS+ LR RL+R L++ +++ L + ++ +A+ +LL + + +
Sbjct 825 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 879
Query 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
F++ GM LF + DG F +L ++ ++ +LT + V+ + +
Sbjct 880 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 939
Query 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
+A ++FI G+ L NLL AI+ F+
Sbjct 940 WAALYFIALMTFGNYVLFNLLVAILVEGFQA 970
>sp|Q2XVR3|SC4AA_DANRE Sodium channel protein type 4 subunit alpha
A OS=Danio rerio OX=7955 GN=scn4aa PE=2 SV=2
Length=1829
Score = 75.9 bits (185), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 127/617 (21%), Positives = 261/617 (42%), Gaps = 117/617 (19%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T +L L + LR R L
Sbjct 1041 IFIVEMLLKWVAYGFKTYFTNAWCWLDFLIVDVSLVSLTANLMGYSELGAIKSLRTLRAL 1100
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1101 RPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAG---------- 1150
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + + + N D M Y+ + + + +G + L+ +
Sbjct 1151 --KFYHCINTTTEERIPMDVVNNKSDCMALMYTNEVRWVNVKVNYDNVG----LGYLSLL 1204
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
+ F+G+ M + ++ R + + ++E+ M + G F L
Sbjct 1205 QIATFKGW-MDIMYAAVDSREVDEQPSYEINLYMYLYFVIFIIFGSFFT----------L 1253
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP---PRPEYQSP 420
+ V +D+ ++Q K + G + EE +K +N + + K+ P PRP S
Sbjct 1254 NLFIGVIIDNFNQQ----KSKFGGKDIFMTEEQKKYYNAMKKLGAKKRPKPIPRP---SN 1306
Query 421 FLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+Q F F +FD ++ N+V+ ++++ D AE++ ++L +N VFIV
Sbjct 1307 IIQGLVFDFISKQFFDIFIMVLICLNMVT----MMIETDDQSAEKE-YVLYQINLVFIVV 1361
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+FAL + + + NVFD V+++L I+ L + + + P + ++
Sbjct 1362 FTSECVLKLFALR-QYFFTIGWNVFD----FVVVILSIAGLMLSDIIEKYFVSPTLFRVI 1416
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M++ A +GL +L ++ ++F+I G+
Sbjct 1417 RLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLIMFIFSIFGM 1467
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
S+ A A NF+ F +++ L+ + W
Sbjct 1468 -------------SNFAYVKKQAGIDDI-------FNFETFGGSIICLFEITTSAGWDGL 1507
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D + P + + +F + ++S ++ VN+++A+ILENF
Sbjct 1508 LLPILNSGPPDCDPDFENPGTDVRGNCGNPGMGIMFFCSYIIMSFLVVVNMYIAIILENF 1567
Query 698 LHKWDPRSHLQPLAGTP 714
++ Q +G P
Sbjct 1568 -------NNAQEESGDP 1577
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 63/283 (22%), Positives = 113/283 (40%), Gaps = 35/283 (12%)
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
DY I L+S D ++ IL + VF +++EMLLK A G +
Sbjct 997 DYFETFIIFMILLSSGALAFEDINIERRRVIKTILEYADKVFTYIFIVEMLLKWVAYGFK 1056
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y + D L+ V LV + L Y S + L L R
Sbjct 1057 TYFTNAWCWLDFLIVDVSLVSLTANLMGY---------------SELGAIKSLRTLRALR 1101
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS- 613
LR + + M VV + ++G + ++ + ++ + +F+I+G+NLF G ++
Sbjct 1102 PLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTE 1161
Query 614 ----LAPANGSAPCGS--FEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL----D 660
+ N + C + + W N N+D+ ++L + W + D
Sbjct 1162 ERIPMDVVNNKSDCMALMYTNEVRWVNVKVNYDNVGLGYLSLLQIATFKGWMDIMYAAVD 1221
Query 661 AYRRYSGPWSKI------YFVLWWLVSSVIWVNLFLALILENF 697
+ P +I YFV++ + S +NLF+ +I++NF
Sbjct 1222 SREVDEQPSYEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1264
Score = 38.9 bits (89), Expect = 0.20, Method: Compositional matrix adjust.
Identities = 74/366 (20%), Positives = 144/366 (39%), Gaps = 71/366 (19%)
Query 283 SKNRAYAIFFIVFTVIGSLFLMNLLTAIIY----SQFRGYLMKSLQTSLFRRRLGTRAAF 338
+ + Y IFF+V +GS +L+NL+ A++ Q L ++ +RL +
Sbjct 385 AAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYDEQNEATLAEARDKEEEFQRLLEQLKN 444
Query 339 EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKV---RSYGSVLLSAEE 395
+ S Q+ G L L + ++ ++ R + LSAEE
Sbjct 445 QETGSKASLASQKTQSRGSNRTGSLHDLADEDVIKDCNGRIVPRLIVNRVSSNKELSAEE 504
Query 396 FQKLFNE------LDRSVVK-----------------EHPPRP------EYQSPFLQ--- 423
QK + LD+ + E RP ++ FL+
Sbjct 505 DQKSLSSKHSMQYLDQPKLSKRTASALSVLTATMEGLEDAQRPCPPGWYKFADMFLKWDC 564
Query 424 -SAQFLFGHY-YFDYLGNLIALANLVSICVFLVLDADVLPAERD------DFILGILNCV 475
+ LF + +F + + L ++IC+ VL+ + E + +L + N V
Sbjct 565 CAPWILFKKWVHFVVMDPFVDLG--ITICI--VLNTLFMAMEHYPMSPHFEHVLSVGNLV 620
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F + EM+ K+ A+ Y N+FD ++ V L ++E+ V L
Sbjct 621 FTGIFTAEMVFKLIAMDPYYYFQVGWNIFDSII-VTLSLVELGLANVQGL---------- 669
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+ R +L VF+ + P++ ++ + +G + N+ +L ++ ++FA+
Sbjct 670 ------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAV 720
Query 596 IGINLF 601
+G+ LF
Sbjct 721 VGMQLF 726
Score = 34.7 bits (78), Expect = 4.3, Method: Compositional matrix adjust.
Identities = 27/91 (30%), Positives = 42/91 (46%), Gaps = 8/91 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y ++D+F A + L+ LM + W+
Sbjct 326 LCGNSSDA---GRCPEGYTCMKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLT 382
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G I+FV+ + S +NL LA++
Sbjct 383 LRAAGKTYMIFFVVVIFLGSFYLINLILAVV 413
>sp|O43497|CAC1G_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1G OS=Homo sapiens OX=9606 GN=CACNA1G PE=1 SV=3
Length=2377
Score = 75.9 bits (185), Expect = 1e-12, Method: Compositional matrix adjust.
Identities = 70/262 (27%), Positives = 123/262 (47%), Gaps = 38/262 (15%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
Y G I +A LV+ + + ++ P E + L I N VF + LEMLLK+ G G
Sbjct 744 YFGRGIMIAILVNT-LSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFG 801
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y+ P N+FDG++ VV+ V EI + G LS+ R++ +L + RF
Sbjct 802 YIKNPYNIFDGVI-VVISVWEIVG-------------QQGGGLSVLRTFRLMRVLKLVRF 847
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
L P+++ VV ++ + N+ F +L++ ++F+I+G++LF G A +
Sbjct 848 L---PALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKFASERDGDTL 900
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
P NFD A+VT++ ++ +W L + W+ +YF+
Sbjct 901 PDR---------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query 676 LWWLVSSVIWVNLFLALILENF 697
+ + NL +A+++E F
Sbjct 946 ALMTFGNYVLFNLLVAILVEGF 967
Score = 66.2 bits (160), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 75/300 (25%), Positives = 134/300 (45%), Gaps = 36/300 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
QS F + H FD++ +I N ++I + + P + L + N +F
Sbjct 1262 QSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAM---ERPKIDPHSAERIFLTLSNYIFT 1318
Query 478 VYYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+L EM +KV ALG + YL NV DGLL ++ ++ + V + G +
Sbjct 1319 AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVI----DILVSMVSDSGTK-- 1372
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---Y 590
+ M R+L +L R LR+I + + +V T L+ +++ G I+V+ +
Sbjct 1373 ------ILGMLRVLRLLRTLRPLRVISRAQGLKLVVET---LMSSLKPIGNIVVICCAFF 1423
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+F I+G+ LF+G G + N S + + NFD+ AL++L+ L
Sbjct 1424 IIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLA 1483
Query 651 VVNNW-QVFLDAYRRYS---------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ W + D PW +YF+ + L+ + +N+F+ +++ENF HK
Sbjct 1484 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF-HK 1542
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 67/278 (24%), Positives = 125/278 (45%), Gaps = 45/278 (16%)
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
HY ++ +I L N+V++ + +L D L I N +F V ++LE + K+ A
Sbjct 1611 HYLDLFITGVIGL-NVVTMAMEHYQQPQIL-----DEALKICNYIFTVIFVLESVFKLVA 1664
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
G R + N D L +VLL + TL E+ SL ++ ++
Sbjct 1665 FGFRRFFQDRWNQLD--LAIVLLSIMGITLE-----------EIEVNASLPINPTIIRIM 1711
Query 551 IVFRFLRIIPSMKL---MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
V R R++ +K+ M + TV+ + + G + ++++++FA +G+ LF +
Sbjct 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL--- 1768
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRR-- 664
+ + PC E L A F +F A +TL+ + +NW + D R
Sbjct 1769 --------ECDETHPC---EGLGRHA-TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCD 1816
Query 665 -----YSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y+ S IYFV + L + + VN+ +A+++++
Sbjct 1817 QESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHL 1854
Score = 43.5 bits (101), Expect = 0.010, Method: Compositional matrix adjust.
Identities = 50/211 (24%), Positives = 104/211 (49%), Gaps = 19/211 (9%)
Query 119 EPPCGLTESVEVLCLL---VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV- 174
E P LT ++E+ ++ +FA ++ +K ++G + KN + + V++V+S+ W +
Sbjct 766 EQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISV--WEIV 823
Query 175 -----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
LS+ LR RL+R L++ +++ L + ++ +A+ +LL + + +
Sbjct 824 GQQGGGLSV-----LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878
Query 230 FTMFGMLLFAG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
F++ GM LF + DG F +L ++ ++ +LT + V+ + +
Sbjct 879 FSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS 938
Query 288 YA-IFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
+A ++FI G+ L NLL AI+ F+
Sbjct 939 WAALYFIALMTFGNYVLFNLLVAILVEGFQA 969
>sp|O88457|SCNBA_RAT Sodium channel protein type 11 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn11a PE=1 SV=1
Length=1765
Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust.
Identities = 128/590 (22%), Positives = 244/590 (41%), Gaps = 105/590 (18%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+F ++ +K FG+ + + W +++VVS++ ++L + R R LRP
Sbjct 1077 FIFLLEMILKWVAFGFRRYFTSAWCWLDFLIVVVSVLSL---MNLPSLKSFRTLRALRPL 1133
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--GKQDDGQDRER 251
L MK + + ++P + +V L+ I +F + G+ LF+G G+ +G D
Sbjct 1134 RALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINM 1193
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
F +P N I YS + + + F +G+ +L L A
Sbjct 1194 YLDFTEVP-------------NRSQCNISNYS----WKVPQVNFDNVGNAYLALLQVAT- 1235
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQNL 362
++G+L + + ++ R + FE V+ + G +GV N
Sbjct 1236 ---YKGWL-EIMNAAVDSREKDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNF 1291
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
Q +K+ G + EE +K +N + + K+ P+ P
Sbjct 1292 NQQQKKLG----------------GQDIFMTEEQKKYYNAMKKLGTKK--PQKPIPRPLN 1333
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+ F+F +I ++++ + + AD + F ILN F+V + +
Sbjct 1334 KCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTF--DILNIAFVVIFTI 1391
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP--GWRPEMVGLLSL 540
E L+KVFAL + Y + N+FD V++VL I + V RL + P + ++ L
Sbjct 1392 ECLIKVFALR-QHYFTNGWNLFD----CVVVVLSIISTLVSRLEDSDISFPPTLFRVVRL 1446
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ R +R + +M++ + +GL +L +V +++AI G++
Sbjct 1447 ARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGL---------LLFLVMFIYAIFGMSW 1497
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F V GS F NF+ F +++ L+ + W L+
Sbjct 1498 FSKV------------KKGSGIDDIF--------NFETFTGSMLCLFQITTSAGWDTLLN 1537
Query 661 AY---RRYSGPWSK----------IYFVLWWLVSSVIWVNLFLALILENF 697
+ + S+ +YFV + ++S +I VN+++A+ILENF
Sbjct 1538 PMLEAKEHCNSSSQDSCQQPQIAVVYFVSYIIISFLIVVNMYIAVILENF 1587
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 89/420 (21%), Positives = 159/420 (38%), Gaps = 103/420 (25%)
Query 346 GEGGAFP---QAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQK---- 398
GEGGA P + GV+ +L + QL S Q + +V S + LS + +K
Sbjct 907 GEGGALPTSQHSAGVQAGDLPP--ETKQLTSPDDQGVEMEVFSEEDLHLSIQSPRKKSDA 964
Query 399 --------------LFNELDRSVV-KEHPPR---------------PEYQSPFL------ 422
+F L ++V K+ P R + +SP++
Sbjct 965 VSMLSECSTIDLNDIFRNLQKTVSPKKQPDRCFPKGLSCHFLCHKTDKRKSPWVLWWNIR 1024
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
++ + H +F+ + I L+S + D ++ + + +L + +F +LL
Sbjct 1025 KTCYQIVKHSWFE---SFIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDNIFTFIFLL 1081
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
EM+LK A G R Y + D L+ VV S L++ LP
Sbjct 1082 EMILKWVAFGFRRYFTSAWCWLDFLIVVV------SVLSLMNLPS--------------- 1120
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
+ L R LR + + M VV ++ + + + ++ + VF I+G+NLF
Sbjct 1121 -LKSFRTLRALRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFS 1179
Query 603 GV---------------IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
G +P S +N S NFD+ A + L
Sbjct 1180 GKFGRCINGTDINMYLDFTEVPNRSQCNISNYSWKVPQV--------NFDNVGNAYLALL 1231
Query 648 NLMVVNNW----QVFLDAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W +D+ + P ++ +YFV++ + S +NLF+ +I++NF
Sbjct 1232 QVATYKGWLEIMNAAVDSREKDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNF 1291
Score = 47.4 bits (111), Expect = 6e-04, Method: Compositional matrix adjust.
Identities = 53/234 (23%), Positives = 99/234 (42%), Gaps = 39/234 (17%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL I N VF ++ EM LK+ AL Y + NVFD ++ ++ L +Y
Sbjct 603 ILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFDSIVALLSL-----ADVLYNTLS 657
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
R + L +L VF+ + P++ + + +G + N+ +L
Sbjct 658 DNNRSFLAS----------LRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTV---VLT 704
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
+V ++F+++G+ LF N +A W + D+F + + ++
Sbjct 705 IVVFIFSVVGMRLFG------------TKFNKTAYATQERPRRRW--HMDNFYHSFLVVF 750
Query 648 NLM----VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
++ + N W D P I FVL ++ ++ +NLF+AL+L +F
Sbjct 751 RILCGEWIENMWGCMQDM---DGSPLCIIVFVLIMVIGKLVVLNLFIALLLNSF 801
Score = 37.0 bits (84), Expect = 0.95, Method: Compositional matrix adjust.
Identities = 54/256 (21%), Positives = 106/256 (41%), Gaps = 60/256 (23%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VFI Y+LE ++K+ A G +L P N D +++ I+T PG
Sbjct 162 VFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLD----FIVIGTAIATC------FPGS 211
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
+ L+ L FR R + ++ +++ + V L+++++ ++V+
Sbjct 212 QVN-------------LSALRTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTL 258
Query 591 Y---VFAIIGINLFRGVI--VALPGNSSLAPAN---------------------GSAPCG 624
+ +FA++G LF G++ + N PA+ GS PC
Sbjct 259 FCLSIFALVGQQLFMGILNQKCIKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCP 318
Query 625 SFEQLEYWANN-------FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLW 677
+ + N FD+F + + ++ +M ++W+ R SG + +FV+
Sbjct 319 NGSTCDKTTLNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVV 378
Query 678 WLVSSVIWVNLFLALI 693
+ S +NL LA++
Sbjct 379 IFLGSFYLLNLTLAVV 394
>sp|O57483|CAC1S_AQUCT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Aquarana catesbeiana OX=8400 PE=2 SV=1
Length=1688
Score = 73.2 bits (178), Expect = 6e-12, Method: Compositional matrix adjust.
Identities = 136/692 (20%), Positives = 272/692 (39%), Gaps = 184/692 (27%)
Query 81 VCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC---GLTESVEVLCLLVFA 137
+C R ++ T F L FI S + D P +P + ++++ ++F
Sbjct 789 LCHRIINATTFTNFILLFILLSSISLAAED------PIQPESFRNKVLSKLDIVFTVIFT 842
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRP 192
++ +K +G F +N + + L V+ VSL+ + S + + LR+ R+LRP
Sbjct 843 TEIVLKMTAYGAFLHKGSFCRNSFNILDLSVVGVSLISMGIESSAISVVKILRVLRVLRP 902
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERL 252
+ + +K ++C+ ++ + ++ L+ + +F+ G+ LF G K D ++
Sbjct 903 LRAINRAKGLKHVVQCLFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKG-KFYSCTDTTKI 961
Query 253 T-------------------------------YFQNLPESLTSLLVLLTTANNPDV---- 277
T +F N+ + SL + T P +
Sbjct 962 TADECRGYFFVAKDGNPAHMEAVPRVWSHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRA 1021
Query 278 -------MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
M P Y+ A+FFIV+ ++ + F+MN+ F G+++ + Q
Sbjct 1022 IDSHAEDMGPIYNYRIEIAVFFIVYIILIAFFMMNI--------FVGFVIVTFQEQ---- 1069
Query 331 RLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVL 390
GE Q + +LD + +Q + +++
Sbjct 1070 ---------------GE----------------QEYKDCELDKNQRQCVQYALKA----- 1093
Query 391 LSAEEFQKLFNELDRSVVKEHPPRP-EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI 449
R + + P P +Y+ ++ ++ YF+YL + N +S+
Sbjct 1094 --------------RPLRRYIPKNPHQYKIWYVVTSS------YFEYLMFFLITLNTISL 1133
Query 450 CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL- 508
+ ++ ILN F + +EM LK+ A +GY P NVFD L+
Sbjct 1134 GM-----QHYGQTAEFSYMSDILNVAFTGIFTVEMFLKLAAFKAKGYFGDPWNVFDFLIV 1188
Query 509 --TVVLLVL-EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
+V+ ++L EI T + P E +S + +FR LR++ +
Sbjct 1189 IGSVIDVILSEIDTPGIPATPG----AEESSRIS-------ITFFRLFRVLRLVKLLSRG 1237
Query 566 AVVASTVLGLVQNMRAF---GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
V + + +++ +A ++V++++++A+IG+ +F G I + G N ++
Sbjct 1238 EGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALVDGTH----INRNS- 1291
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA--YRRYSGPWSK--------- 671
NF F A++ L+ WQ L A Y + P S
Sbjct 1292 ------------NFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPMSDFQPGEEYTC 1339
Query 672 ------IYFVLWWLVSSVIWVNLFLALILENF 697
YF+ ++++ + + +NLF+A+I++NF
Sbjct 1340 GTSFAYFYFISFYMLCAFLIINLFVAVIMDNF 1371
Score = 70.1 bits (170), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 133/650 (20%), Positives = 258/650 (40%), Gaps = 153/650 (24%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE + L +F + +K G++ + +N W L +VS+ ++V L +
Sbjct 87 EKVEYIFLFIFTIESFLKIVAYGFILHTDAYLRNGW--NILDFTIVSVGVFSVLLEQISK 144
Query 182 ---------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
+ LR R+LRP L+ ++ L I ++ + + LL+
Sbjct 145 LQGLPAPGKSSGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFM 204
Query 227 LCLFTMFGMLLFAGG-------KQDD----------------GQDRE------------- 250
+ ++ + G+ LF+G K D GQ R+
Sbjct 205 IIIYAIVGLELFSGKMHKTCYFKDTDITATVDNEKPAPCSSTGQGRQCSINGSECRGWWP 264
Query 251 ----RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSL 301
+T+F N ++ ++ +T +V+ Y N A I+F+ ++GS
Sbjct 265 GPNNGITHFDNFGFAMLTVYQCITMEGWTEVL---YWVNDAIGNEWPWIYFVSLILLGSF 321
Query 302 FLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG-EGGAFPQAVGVKPQ 360
F++NL+ ++ +F K+ F+ +A E L + A ++P+
Sbjct 322 FVLNLVLGVLSGEFTKEREKAKSRGAFQMLREQQAMDEDLRGYLDWITHAEVMDPDMEPR 381
Query 361 NLLQVLQK--VQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ 418
+ L++ + DS ++ +E + + + + +L R +VK
Sbjct 382 DGFSQLEEGGSETDSLYE---IEGINKFIAFFRQWRLWHRLLRRKSRDLVKSR------- 431
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+F +L +I L N V I D L +D I N V +
Sbjct 432 --------------FFYWLVIIIILLNTVIIATEHHHQPDSLTKAQD-----IANEVLLA 472
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEISTLAVYRLPHPGWRP 532
+ +EM++K++ALG + Y N FD GLL V+L+ +I + P
Sbjct 473 LFTMEMIVKIYALGFQSYFMSLFNRFDSFVVCTGLLEVMLVASDIMS------------P 520
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ +L R + +L +F+ R S+ + +++L V+++ + +L + +
Sbjct 521 LGISVL------RCIRLLRIFKITRYWTSLNNL---VASLLNSVRSIASLLLLLFLFMII 571
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
FA++G+ +F G FE LE + FD F AL+T++ ++
Sbjct 572 FALLGMQMFGGKF-------------------DFEDLEVRRSTFDTFPQALITVFQILTG 612
Query 653 NNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W V + Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 613 EDWTAVMYNGIMAYGGPTYSGMSVCIYFIILFVCGNYILLNVFLAIAVDN 662
Score = 60.8 bits (146), Expect = 4e-08, Method: Compositional matrix adjust.
Identities = 137/663 (21%), Positives = 268/663 (40%), Gaps = 128/663 (19%)
Query 121 PCGLTESVEV---LCLLVFAADLSVKGYLFGWAHFQKNLW--------LLGYL-VVLVVS 168
P LT++ ++ + L +F ++ VK Y G+ + +L+ G L V+LV S
Sbjct 456 PDSLTKAQDIANEVLLALFTMEMIVKIYALGFQSYFMSLFNRFDSFVVCTGLLEVMLVAS 515
Query 169 LVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
+ + +S+ LR RLLR F + + + + + + S+ +AS+ LLL + +
Sbjct 516 DIMSPLGISV-----LRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMI 570
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI--------P 280
+F + GM +F GGK D R + F P++L ++ +LT + VM P
Sbjct 571 IFALLGMQMF-GGKFDFEDLEVRRSTFDTFPQALITVFQILTGEDWTAVMYNGIMAYGGP 629
Query 281 AYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFE 339
YS + I+FI+ V G+ L+N+ AI + S Q + R + A
Sbjct 630 TYS-GMSVCIYFIILFVCGNYILLNVFLAIAVDNLAEAENLTSAQKAKAEERKRKKLA-- 686
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
P + +K+ L ++A E + + + L +EF+
Sbjct 687 ----------------RANPDKTEE--EKLLLAKKEQKAKGEGIPT--TARLKIDEFESN 726
Query 400 FNEL-DRSVVKEHP-------------PRP---------EYQSPFLQSAQF--------- 427
NE+ D + P PRP E P +++ F
Sbjct 727 VNEIKDPYPSADFPGDDEEEEPEIPISPRPRPLAELQLKEKAVPMPEASSFFIFSPTNKI 786
Query 428 -LFGHYYFD--YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM 484
+ H + N I L L+S + L + + P + +L L+ VF V + E+
Sbjct 787 RVLCHRIINATTFTNFILLFILLS-SISLAAEDPIQPESFRNKVLSKLDIVFTVIFTTEI 845
Query 485 LLKVFALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLW 541
+LK+ A G +G S+ N F+ +L++S + V L G + ++
Sbjct 846 VLKMTAYGAFLHKG--SFCRNSFN--------ILDLSVVGV-SLISMGIESSAISVV--- 891
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
++L +L V R LR I K + V + ++ + + ++ ++F+ IG+ LF
Sbjct 892 ---KILRVLRVLRPLRAINRAKGLKHVVQCLFVAIKTIGNIVLVTTLLQFMFSCIGVQLF 948
Query 602 RGVIVALPGNSSLAP---------ANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWNL 649
+G + + + A P W++ +FD+ + +++L+ +
Sbjct 949 KGKFYSCTDTTKITADECRGYFFVAKDGNPAHMEAVPRVWSHSDFHFDNVLSGMMSLFTI 1008
Query 650 MVVNNWQVFL----DAYRRYSGPWSK------IYFVLWWLVSSVIWVNLFLALILENFLH 699
W L D++ GP ++F+++ ++ + +N+F+ ++ F
Sbjct 1009 STFEGWPQLLYRAIDSHAEDMGPIYNYRIEIAVFFIVYIILIAFFMMNIFVGFVIVTFQE 1068
Query 700 KWD 702
+ +
Sbjct 1069 QGE 1071
Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 71/314 (23%), Positives = 127/314 (40%), Gaps = 43/314 (14%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
Q+PF + + F+ + L AN V++ +FL + D + +L + +F+
Sbjct 37 QNPFRKFCINIVEWKPFEMIILLTIFANCVALAIFLPMPED--DTNSTNSVLEKVEYIFL 94
Query 478 VYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVV----LLVLEISTLAVYRLPHPG 529
+ +E LK+ A G YL N+ D + V +L+ +IS L LP PG
Sbjct 95 FIFTIESFLKIVAYGFILHTDAYLRNGWNILDFTIVSVGVFSVLLEQISKLQ--GLPAPG 152
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+ L V R LR++ + + VV ++++ + + +++ +
Sbjct 153 KSSGF--------NVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFM 204
Query 590 YYVFAIIGINLFRGV-----------IVALPGNSSLAPA-----------NGSAPCGSFE 627
++AI+G+ LF G I A N AP NGS G +
Sbjct 205 IIIYAIVGLELFSGKMHKTCYFKDTDITATVDNEKPAPCSSTGQGRQCSINGSECRGWWP 264
Query 628 QLEYWANNFDDFAAALVTLWNLMVVNNW-QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV 686
+FD+F A++T++ + + W +V W IYFV L+ S +
Sbjct 265 GPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVL 324
Query 687 NLFLALILENFLHK 700
NL L ++ F +
Sbjct 325 NLVLGVLSGEFTKE 338
>sp|Q02294|CAC1B_RAT Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Rattus norvegicus OX=10116 GN=Cacna1b PE=1
SV=1
Length=2336
Score = 70.5 bits (171), Expect = 4e-11, Method: Compositional matrix adjust.
Identities = 140/628 (22%), Positives = 250/628 (40%), Gaps = 131/628 (21%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
G++F + +N W ++ ++VVL L L LR R+LRP L+ +
Sbjct 153 GFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDL---RTLRAVRVLRPLKLVSGIPSL 209
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG---------------------G 241
+ LK I ++ + +GLLL + +F + G+ + G G
Sbjct 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query 242 KQ-------DDGQDRE-------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
K+ D + RE +T F N+ ++ ++ +T D++ Y+ N A
Sbjct 270 KEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL---YNTNDA 326
Query 288 YA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVL- 341
++FI +IGS F++NL+ ++ +F + R R+ R AF L
Sbjct 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF----------AKERERVENRRAFLKLR 376
Query 342 --SSMVGEGGAFPQAVGVKPQNLL-----QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
+ E + + + + +L +K LD+ K+A +K R+ L+ AE
Sbjct 377 RQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRND---LIHAE 433
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ-FLFGHYYFDYLGNLIALAN-------- 445
E + F +D R +S +S+ F F +L + A
Sbjct 434 EGEDRF--VDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLC 491
Query 446 ---LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
L ++CV +V +R L VF+ +L EM LK++ LG R Y N
Sbjct 492 VVALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFN 548
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
FD +V + E+ A+ PG + +++L R LRI
Sbjct 549 CFD-FGVIVGSIFEVVWAAI----KPG-------------TSFGISVLRALRLLRIFKVT 590
Query 563 KLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
K + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 591 KYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-------------- 636
Query 620 SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK-----IYF 674
+F Q E NFD F AA++T++ ++ +W + G SK YF
Sbjct 637 -----NF-QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 690
Query 675 VLWWLVSSVIWVNLFLALILENFLHKWD 702
++ L + +N+FLA+ ++N + +
Sbjct 691 IVLTLFGNYTLLNVFLAIAVDNLANAQE 718
Score = 56.6 bits (135), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 70/287 (24%), Positives = 122/287 (43%), Gaps = 51/287 (18%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGL--- 493
LA +++ C+ L L D D P +ER L FI + E +K+ ALG
Sbjct 102 LATIIANCIVLALEQHLPDGDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFVFH 157
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+G SY N ++ + VV+L ++T + +D+ R L + V
Sbjct 158 KG--SYLRNGWNVMDFVVVLTEILATAG-----------------TDFDL-RTLRAVRVL 197
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-VALPGNS 612
R L+++ + + VV +++ + + G +L +FAIIG+ + G A NS
Sbjct 198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS 257
Query 613 SLAPANGSAPCGS----------FEQLEYWA------NNFDDFAAALVTLWNLMVVNNWQ 656
+ A G PCG E EYW NFD+ A++T++ + + W
Sbjct 258 TDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWT 317
Query 657 VFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L +G W+ +YF+ ++ S +NL L ++ F + +
Sbjct 318 DILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 364
Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 58/253 (23%), Positives = 104/253 (41%), Gaps = 64/253 (25%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ +L LN VF + LE +LK+ A G+ Y NVFD +TV+ + +I
Sbjct 1502 ELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFD-FVTVLGSITDIL------- 1553
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL------GLVQNM 579
+T + N I FLR+ + +L+ + VQ+
Sbjct 1554 -----------------VTEIANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSF 1596
Query 580 RAFGGILVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNF 636
+A + +++ ++++AIIG+ +F +AL +S+ NNF
Sbjct 1597 KALPYVCLLIAMLFFIYAIIGMQVFGN--IALDDGTSIN----------------RHNNF 1638
Query 637 DDFAAALVTLWNLMVVNNWQVFL---------DAYRRYS---GPWSKIYFVLWWLVSSVI 684
F AL+ L+ W + D + S ++ YFV + + S +
Sbjct 1639 RTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFL 1698
Query 685 WVNLFLALILENF 697
+NLF+A+I++NF
Sbjct 1699 MLNLFVAVIMDNF 1711
Score = 38.9 bits (89), Expect = 0.21, Method: Compositional matrix adjust.
Identities = 66/285 (23%), Positives = 112/285 (39%), Gaps = 46/285 (16%)
Query 413 PRP--EYQSPFLQSAQFL---FGHY-----YFDYLGNLIALANLVSICVFLVLDADVLPA 462
PRP Y S F S L F HY YF+ + LV I + + A P
Sbjct 1119 PRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFE-------MVILVVIALSSIALAAEDPV 1171
Query 463 ERDDF---ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
D F L ++ +F + EM++K+ LGL L +P F L ++ ++
Sbjct 1172 RTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGL---LLHPGAYFRDLWNILDFIVVSGA 1228
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
L + +G D+ + L V R LR + ++K + + + +V ++
Sbjct 1229 LVAFAFS------SFMGGSKGKDIN-TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSL 1281
Query 580 RAFGGILVV---VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN-- 634
+ IL+V ++FA+I + LF+G S + +E+ E A
Sbjct 1282 KNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPR 1341
Query 635 -------NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
++D+ AL+TL+ + W + L DA GP
Sbjct 1342 QWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1386
Score = 34.7 bits (78), Expect = 4.6, Method: Compositional matrix adjust.
Identities = 47/210 (22%), Positives = 85/210 (40%), Gaps = 29/210 (14%)
Query 135 VFAADLSVKGYLFGWAHFQKNLW-------LLGYLV-VLVVSLVDWTVSLSLVCHEPLRI 186
+F+ + +K FG ++ ++ W +LG + +LV + + ++LS LR+
Sbjct 1515 MFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSF-----LRL 1569
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R R L + ++ L S + V LL+A+ ++ + GM +F DDG
Sbjct 1570 FRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDG 1629
Query 247 QDRERLTYFQNLPESLTSLL--------------VLLTTANNPDVMIPAYSKNRAYAIFF 292
R F+ ++L L L A +P + AY +F
Sbjct 1630 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAY-FYF 1688
Query 293 IVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ F + S ++NL A+I F YL +
Sbjct 1689 VSFIFLCSFLMLNLFVAVIMDNFE-YLTRD 1717
>sp|P56698|CAC1B_DIPOM Probable voltage-dependent N-type calcium
channel subunit alpha-1B OS=Diplobatis ommata OX=1870830
PE=2 SV=1
Length=2326
Score = 69.7 bits (169), Expect = 9e-11, Method: Compositional matrix adjust.
Identities = 138/620 (22%), Positives = 250/620 (40%), Gaps = 131/620 (21%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
G+ F + +N W ++ ++VVL L L LR R+LRP L+ +
Sbjct 146 GFAFHKGSYLRNGWNVMDFVVVLTGILTTIGTDFDL---RTLRAVRVLRPLKLVSGIPSL 202
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG------KQDDGQDRER----- 251
+ LK I ++ + +GLLL + +F + G+ + G ++ + E
Sbjct 203 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKTCFSEETNEPVEEFPCGT 262
Query 252 -----------------------LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
+T F N+ ++ ++ +T D++ Y+ N A
Sbjct 263 KYPSRLCPNGTVCKGYWNGPNFGITNFDNILFAVLTVFQCITMEGWTDML---YTANDAL 319
Query 289 A-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVL-- 341
++FI VIGS F++NL+ ++ +F + R R+ R AF L
Sbjct 320 GNTWNWLYFIPLIVIGSFFMLNLVLGVLSGEF----------AKERERVENRRAFLKLRR 369
Query 342 -SSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH----KQAMMEKVRSYGSVLLSAEEF 396
+ E + + + + + +L K D K+A +K ++ L++AEE
Sbjct 370 QQQVEQEFNRYLRWIHIAEEVMLAEEDKNAEDKCALDVLKRATTKKSKN---DLINAEEG 426
Query 397 QKLFNELD---------RSVVKEHPP---RPEYQSPFLQSAQFLFGHYYFDYLGNLIALA 444
+ F ++ +SV E R E + F +Y+ L L
Sbjct 427 EDHFTDISSVGFNRPSLKSVKNERSSYFRRKEKRFRFFIRRMVKSQSFYWIVL----CLV 482
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
L ++CV +V D P D L VF+ +L EM LK++ LG R Y N F
Sbjct 483 GLNTLCVAIV-HYDQPPLLTD--ALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCF 539
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL 564
D +V + E+ AV +P D + +++L R LRI K
Sbjct 540 D-FGVIVGSIFEVVWTAV--------KP---------DTSFGISVLRALRLLRIFKVTKY 581
Query 565 MAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
+ + V+ L+ +M+ + +L + VFA++G+ LF G +G+
Sbjct 582 WNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG---------QFNFEDGTP 632
Query 622 PCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRR-YSGPWSKIYFVL 676
P NFD F AA++T++ ++ +W + +A+ G +S +YF++
Sbjct 633 P-----------TNFDTFPAAILTVFQILTGEDWNEVMYYGIEAHGGVKKGMFSSVYFII 681
Query 677 WWLVSSVIWVNLFLALILEN 696
L + +N+FLA+ ++N
Sbjct 682 LTLFGNYTLLNVFLAIAVDN 701
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 64/285 (22%), Positives = 119/285 (42%), Gaps = 48/285 (17%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
LA +++ C+ L L D D P +ER L FI + E +K+ ALG +
Sbjct 95 LATIIANCIVLALEQHLPDGDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFAFH 150
Query 497 L-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
SY N ++ + VV+L ++T+ + +D+ R L + V R
Sbjct 151 KGSYLRNGWNVMDFVVVLTGILTTIG-----------------TDFDL-RTLRAVRVLRP 192
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV----------- 604
L+++ + + VV +++ + + G +L +FAIIG+ + G
Sbjct 193 LKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKTCFSEETN 252
Query 605 --IVALPGN----SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ P S L P NG+ G + + NFD+ A++T++ + + W
Sbjct 253 EPVEEFPCGTKYPSRLCP-NGTVCKGYWNGPNFGITNFDNILFAVLTVFQCITMEGWTDM 311
Query 659 L-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L A W+ +YF+ ++ S +NL L ++ F + +
Sbjct 312 LYTANDALGNTWNWLYFIPLIVIGSFFMLNLVLGVLSGEFAKERE 356
Score = 40.0 bits (92), Expect = 0.10, Method: Compositional matrix adjust.
Identities = 52/263 (20%), Positives = 109/263 (41%), Gaps = 28/263 (11%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P ++ ++ YF+ L+ + +++ + D A R++ +L L+ VF
Sbjct 1134 NPVRRACHYIVNLRYFEMCILLVITMSSIALAAEDPVQGD---APRNN-VLKYLDYVFTG 1189
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM++K+ LGL + +P + F L ++ ++ L + G R + + +
Sbjct 1190 VFTFEMVIKMINLGL---ILHPGSYFRDLWNILDFIVVSGALVAFAFT--GSRGKDLNTI 1244
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ L +L V R L+ I + + V V+ ++N+ + ++ ++FA+I +
Sbjct 1245 ------KSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAV 1298
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN---------NFDDFAAALVTLWNL 649
LF+G S + ++ E A ++D+ AL+TL+ +
Sbjct 1299 QLFKGKFFYCTDESKDLEKDCRGQYLVYDNDEIEAEPREWKKCDFHYDNVLWALLTLFTV 1358
Query 650 MVVNNWQVFL----DAYRRYSGP 668
W L DA GP
Sbjct 1359 STGEGWPTVLKNSIDATEEDQGP 1381
Score = 39.3 bits (90), Expect = 0.19, Method: Compositional matrix adjust.
Identities = 66/281 (23%), Positives = 118/281 (42%), Gaps = 59/281 (21%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F+YL ++AL L +I + + P +R +L LN +F + +E +LK+ G+
Sbjct 1470 FEYL--IMALIALNTIVLMMKFYNAPDPYDR---MLQYLNILFTFLFSMECVLKLIGFGV 1524
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
Y NVFD +TV+ + +I + L D L+ L +F
Sbjct 1525 LNYFRDAWNVFD-FVTVLGSITDIL------------------VTELADSFINLSFLRLF 1565
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIGINLFRGVIVALPG 610
R R+I ++ + + VQ+ +A + +++ ++++AIIG+ +F G
Sbjct 1566 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF--------G 1617
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DA 661
N L G+ + NNF F A++ L WQ + DA
Sbjct 1618 NIELDDD------GAINR----HNNFRTFLQAVMLLLRSATGEGWQEIMLACLNQSPCDA 1667
Query 662 YRRYSGPWSKIYFVLWWLVSSV-----IWVNLFLALILENF 697
G F ++ VS + + +NLF+A+I++NF
Sbjct 1668 RSGIDGDECGSNFAYFYFVSFIFFSSFLMLNLFVAVIMDNF 1708
Score = 36.2 bits (82), Expect = 1.6, Method: Compositional matrix adjust.
Identities = 54/211 (26%), Positives = 104/211 (49%), Gaps = 25/211 (12%)
Query 118 WEPPCGLTESV---EVLCLLVFAADLSVKGYLFG---WAHFQKNLWLLGYLVVLVVSLV- 170
++ P LT+++ E + L +F ++S+K Y G + H N + G +V + +V
Sbjct 494 YDQPPLLTDALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCFDFGVIVGSIFEVVW 553
Query 171 -----DWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
D + +S+ LR RLLR F + + + ++ + + S+ + S+ LL +
Sbjct 554 TAVKPDTSFGISV-----LRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFL 608
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAY 282
+ +F + GM LF G Q + +D T F P ++ ++ +LT + +VM I A+
Sbjct 609 FIVVFALLGMQLFGG--QFNFEDGTPPTNFDTFPAAILTVFQILTGEDWNEVMYYGIEAH 666
Query 283 ---SKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
K +++FI+ T+ G+ L+N+ AI
Sbjct 667 GGVKKGMFSSVYFIILTLFGNYTLLNVFLAI 697
>sp|Q61290|CAC1E_MOUSE Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Mus musculus OX=10090 GN=Cacna1e PE=1
SV=1
Length=2272
Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 145/664 (22%), Positives = 261/664 (39%), Gaps = 174/664 (26%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E + +F + +K G++F + +N W ++ ++VVL L T
Sbjct 126 EKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILA--TAGTHFNT 183
Query 181 H---EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
H LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+
Sbjct 184 HVDLRALRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 243
Query 238 FAGGKQD----------DGQD----------------------RERLTYFQNLPESLTSL 265
++G +G D + +T F N+ ++ ++
Sbjct 244 YSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTV 303
Query 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
+T V+ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 304 FQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 360
Query 316 -----RGYLMKSLQTSLFRRRLGTRA----AFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
R ++ Q + R G RA A EV+ + + + L+VL
Sbjct 361 RVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSG---------TSALEVL 411
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
++ + S +AM V +S+ + L R+ +K +
Sbjct 412 RRATIKRSRTEAMTRDSSDEHCVDISS-----VGTPLARASIK---------------ST 451
Query 427 FLFGHYYFDYLGNL--IALANLVSICVF--LVLDADVLPAERDDFILGILNCVFIVYY-- 480
+ G YF + L I++ ++V VF +VL L CV IV++
Sbjct 452 KVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTA----------CVAIVHHNQ 501
Query 481 -------------------LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
LLEM LK++ +G R Y N FD +TV + E+ A
Sbjct 502 PQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS-IFEV-VWA 559
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
++R PG + +++L R LRI K A + + V+ L+ +M++
Sbjct 560 IFR---PG-------------TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKS 603
Query 582 FGGILVVVYYVF---AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
+L +++ A++G+ LF G G S NFD
Sbjct 604 IISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA--------------------NFDT 643
Query 639 FAAALVTLWNLMVVNNW-QVFLDAYRRY----SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
F AA++T++ ++ +W +V + R SG WS IYF++ L + +N+FLA+
Sbjct 644 FPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIA 703
Query 694 LENF 697
++N
Sbjct 704 VDNL 707
Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 57/254 (22%), Positives = 101/254 (40%), Gaps = 56/254 (22%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ L LN F + + LE +LKV A G Y N+FD +TV+ + EI +
Sbjct 1510 ELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD-FITVIGSITEIILTDSKLV 1568
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G+ ++ L +FR R+I ++ + + VQ+ +A +
Sbjct 1569 NTSGFN---------------MSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1613
Query 586 LVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+++ ++++AIIG+ +F GN L E NNF F +
Sbjct 1614 CLLIAMLFFIYAIIGMQVF--------GNIKLDE----------ESHINRHNNFRSFFGS 1655
Query 643 LVTLWNLMVVNNWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSV 683
L+ L+ WQ + + R + +YFV + S
Sbjct 1656 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSF 1715
Query 684 IWVNLFLALILENF 697
+ +NLF+A+I++NF
Sbjct 1716 LMLNLFVAVIMDNF 1729
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 63/287 (22%), Positives = 120/287 (42%), Gaps = 46/287 (16%)
Query 434 FDYLGNLIALANLVSICVFLVLDA-----DVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
F+Y+ LA +++ C+ L L+ D P R L FI + E +K+
Sbjct 92 FEYM----ILATIIANCIVLALEQHLPEDDKTPMSRR---LEKTEPYFIGIFCFEAGIKI 144
Query 489 FALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
ALG +G SY N ++ + +V+L ++T + H V L R
Sbjct 145 VALGFIFHKG--SYLRNGWNVMDFIVVLSGILATAGTHFNTH-------VDL-------R 188
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + V R L+++ + + +V +++ + + G +L +FAIIG+ + G +
Sbjct 189 ALRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 248
Query 606 --VALPGNSSLAPA-NGSAPCG------SFEQLEYWANN-----FDDFAAALVTLWNLMV 651
NS + + PCG +E ++ N FD+ A++T++ +
Sbjct 249 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 308
Query 652 VNNWQVFL-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W L + W+ +YF+ ++ S +NL L ++ F
Sbjct 309 MEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 355
Score = 37.0 bits (84), Expect = 1.0, Method: Compositional matrix adjust.
Identities = 43/218 (20%), Positives = 88/218 (40%), Gaps = 33/218 (15%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP------LRIR 187
+VF+ + +K FG+ ++ ++ W + + ++ S+ + ++ S + + L++
Sbjct 1522 MVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLF 1581
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R R LL+ ++ L S + V LL+A+ ++ + GM +F K D+
Sbjct 1582 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEES 1641
Query 248 DRERLTYFQNLPESLTSLLVLLTTAN-----------------NPDVMIPAYSKNRAYA- 289
R F++ SL++L +A PD P+
Sbjct 1642 HINRHNNFRSF---FGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESERCG 1698
Query 290 -----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
++F+ F S ++NL A+I F YL +
Sbjct 1699 TDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFE-YLTRD 1735
Score = 34.3 bits (77), Expect = 5.8, Method: Compositional matrix adjust.
Identities = 29/132 (22%), Positives = 63/132 (48%), Gaps = 15/132 (11%)
Query 135 VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE-------- 182
VF ++ +K G + + ++LW + VV+V +LV + ++ +L ++
Sbjct 1199 VFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIK 1258
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG- 241
LR+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1259 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF 1318
Query 242 --KQDDGQDRER 251
D +D E+
Sbjct 1319 FYCTDSSKDTEK 1330
Score = 34.3 bits (77), Expect = 6.0, Method: Compositional matrix adjust.
Identities = 33/148 (22%), Positives = 68/148 (46%), Gaps = 13/148 (9%)
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIS 518
VL + +L + VF + EM++K+ GL + + F L ++ V+ +
Sbjct 1179 VLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL---ILQDGSYFRDLWNILDFVVVVG 1235
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
L + L + +G D+ + + L V R LR + ++K + + + +V +
Sbjct 1236 ALVAFALAN------ALGTNKGRDI-KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTS 1288
Query 579 MRAFGGILVVVY---YVFAIIGINLFRG 603
++ IL+V ++FA+I + LF+G
Sbjct 1289 LKNVFNILIVYKLFMFIFAVIAVQLFKG 1316
>sp|P0DMA5|SCNAA_ONYTO Sodium channel protein type 10 subunit
alpha OS=Onychomys torridus OX=38674 GN=Scn10a PE=1 SV=1
Length=1959
Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 124/609 (20%), Positives = 250/609 (41%), Gaps = 107/609 (18%)
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVV------LVVSLVDWTVSLSL 178
E + + +F ++ +K +G+ + N W L +L+V L+ ++D++ SL
Sbjct 1189 EYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILDYSDVASL 1248
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LF
Sbjct 1249 ---KALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1305
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI 298
AG R N P S+ V T NN ++N F++ V
Sbjct 1306 AG-------KFSRCIDTSNNPFSV----VNSTIVNNKS---ECRNQNHTGHFFWVNVKVN 1351
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAF 351
M L + + F+G+ M + ++ R + ++ +E M + GG F
Sbjct 1352 FDNVAMGYLALLQVATFKGW-MDIMYAAVDSREINSQPQWEDNLYMYLYFVVFIIFGGFF 1410
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
L + V +D+ ++Q K + G + EE +K +N + + K+
Sbjct 1411 ----------TLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKK- 1455
Query 412 PPRPEYQSPFLQSAQFLFG---HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI 468
P+ P + F+F FD + ++ N+++ ++++ D E+ I
Sbjct 1456 -PQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMIT----MMVETDGQSEEKTK-I 1509
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
LG +N F+ + E ++K+FAL + Y + NVFD + V+L + + A+ +
Sbjct 1510 LGRINQFFVAVFTGECVMKMFAL-RQYYFTNGWNVFD-FIVVILSIGSLVFSAILKSLES 1567
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
+ P + ++ L + R+L ++ + +R + +M++ A +GL +L +
Sbjct 1568 YFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGL---------LLFL 1618
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
V ++++I G+ F V+ + NF F +++ L+
Sbjct 1619 VMFIYSIFGMASFANVVEEAGIDDMF--------------------NFQTFGNSMLCLFQ 1658
Query 649 LMVVNNWQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNL 688
+ W L P+ ++F + ++S +I VN+
Sbjct 1659 ITTSAGWDGLLSPILNTGPPYCDPNLSNNNTSKGNCGSPTVGIVFFTTYIIISFLIVVNM 1718
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1719 YIAVILENF 1727
Score = 53.9 bits (128), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 60/261 (23%), Positives = 102/261 (39%), Gaps = 66/261 (25%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
F V Y E L+K+ A G YL P N D +V L + G
Sbjct 159 AFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLD--------------FSVITLAYVGA 204
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
++ G+ L R +L + + +IP +K++ V L+ ++R + ++
Sbjct 205 AIDLRGISGL----RTFRVLRALKTVSVIPGLKVI------VGALIHSVRKLADVTILTV 254
Query 591 Y---VFAIIGINLFRGVIVALPGNSSLAPAN----------------------------- 618
+ VFA++G+ LF+G + S P N
Sbjct 255 FCLSVFALVGLQLFKGNLKNKCIKRSTDPHNAYNFSSQMADNFYIKNGTTEPLLCGNGSD 314
Query 619 -GSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
G P G + + ++ +FD FA A ++L+ LM ++W+ R SG +
Sbjct 315 AGHCPSGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMV 374
Query 673 YFVLWWLVSSVIWVNLFLALI 693
+FVL + S VNL LA++
Sbjct 375 FFVLVIFLGSFYLVNLILAVV 395
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 54/233 (23%), Positives = 97/233 (42%), Gaps = 34/233 (15%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG-LLTVVLLVLEISTLAVYR 524
D +L N VF V++ +EM K+ A Y NVFD ++TV LL L I+
Sbjct 694 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNVFDCVIVTVSLLELSIAK----- 748
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
G LS+ R +L VF+ + P++ + + +G + N+
Sbjct 749 ----------KGSLSVL---RTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTF--- 792
Query 585 ILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
IL ++ ++FA++G L G +G+A + + + F F
Sbjct 793 ILAIIVFIFALVGKQLL--------GEDYGCRKDGTALWNEGQLRWHMCDFFHSFLVIFR 844
Query 645 TLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
L + N W + + I F+ ++ +++ +NLF+AL+L +F
Sbjct 845 ILCGEWIENMWVCMQVSEKSI----CLILFLTVMVLGNLVVLNLFIALLLNSF 893
Score = 34.7 bits (78), Expect = 4.8, Method: Compositional matrix adjust.
Identities = 54/219 (25%), Positives = 98/219 (45%), Gaps = 38/219 (17%)
Query 151 HFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTL 206
+FQK W + V++ VSL++ ++ SLS+ LR RLLR F L ++ + +
Sbjct 724 YFQKK-WNVFDCVIVTVSLLELSIAKKGSLSV-----LRTFRLLRVFKLAKSWPTLNTLI 777
Query 207 KCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA---GGKQD------DGQDRERLTYFQN 257
K I S+ + ++ +LAI + +F + G L G ++D +GQ R + F
Sbjct 778 KIIGNSVGALGNLTFILAIIVFIFALVGKQLLGEDYGCRKDGTALWNEGQLRWHMCDF-- 835
Query 258 LPESLTSLLVLLTTANNPDV----MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
S LV+ + + S+ I F+ V+G+L ++NL A++ +
Sbjct 836 ----FHSFLVIFRILCGEWIENMWVCMQVSEKSICLILFLTVMVLGNLVVLNLFIALLLN 891
Query 314 QFRGYLM---------KSLQTSLFRRRLGTRAAFEVLSS 343
F + +LQ +L R + + A + +SS
Sbjct 892 SFSADNLTAPEDDGEVNNLQVALARTQAFGQRASQAISS 930
>sp|Q07652|CAC1E_RAT Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Rattus norvegicus OX=10116 GN=Cacna1e PE=1
SV=1
Length=2222
Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 145/664 (22%), Positives = 261/664 (39%), Gaps = 174/664 (26%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E + +F + +K G++F + +N W ++ ++VVL L T
Sbjct 76 EKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILA--TAGTHFNT 133
Query 181 H---EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
H LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+
Sbjct 134 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 193
Query 238 FAGGKQD----------DGQD----------------------RERLTYFQNLPESLTSL 265
++G +G D + +T F N+ ++ ++
Sbjct 194 YSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTV 253
Query 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
+T V+ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 254 FQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 310
Query 316 -----RGYLMKSLQTSLFRRRLGTRA----AFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
R ++ Q + R G RA A EV+ + + + L+VL
Sbjct 311 RVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSG---------TSALEVL 361
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
++ + S +AM V +S+ + L R+ +K +
Sbjct 362 RRATIKRSRTEAMTRDSSDEHCVDISS-----VGTPLARASIK---------------ST 401
Query 427 FLFGHYYFDYLGNL--IALANLVSICVF--LVLDADVLPAERDDFILGILNCVFIVYY-- 480
+ G YF + L I++ ++V VF +VL L CV IV++
Sbjct 402 KVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTA----------CVAIVHHNQ 451
Query 481 -------------------LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
LLEM LK++ +G R Y N FD +TV + E+ A
Sbjct 452 PQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS-IFEV-VWA 509
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
++R PG + +++L R LRI K A + + V+ L+ +M++
Sbjct 510 IFR---PG-------------TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKS 553
Query 582 FGGILVVVYYVF---AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
+L +++ A++G+ LF G G S NFD
Sbjct 554 IISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA--------------------NFDT 593
Query 639 FAAALVTLWNLMVVNNW-QVFLDAYRRY----SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
F AA++T++ ++ +W +V + R SG WS IYF++ L + +N+FLA+
Sbjct 594 FPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIA 653
Query 694 LENF 697
++N
Sbjct 654 VDNL 657
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 57/254 (22%), Positives = 101/254 (40%), Gaps = 56/254 (22%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ L LN F + + LE +LKV A G Y N+FD +TV+ + EI +
Sbjct 1459 ELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD-FITVIGSITEIILTDSKLV 1517
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G+ ++ L +FR R+I ++ + + VQ+ +A +
Sbjct 1518 NTSGFN---------------MSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1562
Query 586 LVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+++ ++++AIIG+ +F GN L E NNF F +
Sbjct 1563 CLLIAMLFFIYAIIGMQVF--------GNIKLDE----------ESHINRHNNFRSFFGS 1604
Query 643 LVTLWNLMVVNNWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSV 683
L+ L+ WQ + + R + +YFV + S
Sbjct 1605 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSF 1664
Query 684 IWVNLFLALILENF 697
+ +NLF+A+I++NF
Sbjct 1665 LMLNLFVAVIMDNF 1678
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 63/287 (22%), Positives = 120/287 (42%), Gaps = 46/287 (16%)
Query 434 FDYLGNLIALANLVSICVFLVLDA-----DVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
F+Y+ LA +++ C+ L L+ D P R L FI + E +K+
Sbjct 42 FEYM----ILATIIANCIVLALEQHLPEDDKTPMSRR---LEKTEPYFIGIFCFEAGIKI 94
Query 489 FALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
ALG +G SY N ++ + +V+L ++T + H V L R
Sbjct 95 VALGFIFHKG--SYLRNGWNVMDFIVVLSGILATAGTHFNTH-------VDL-------R 138
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + V R L+++ + + +V +++ + + G +L +FAIIG+ + G +
Sbjct 139 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 198
Query 606 --VALPGNSSLAPA-NGSAPCG------SFEQLEYWANN-----FDDFAAALVTLWNLMV 651
NS + + PCG +E ++ N FD+ A++T++ +
Sbjct 199 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 258
Query 652 VNNWQVFL-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W L + W+ +YF+ ++ S +NL L ++ F
Sbjct 259 MEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 305
Score = 40.8 bits (94), Expect = 0.054, Method: Compositional matrix adjust.
Identities = 48/241 (20%), Positives = 99/241 (41%), Gaps = 34/241 (14%)
Query 111 VRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLV 170
++Y +APW L + + + +VF+ + +K FG+ ++ ++ W + + ++ S+
Sbjct 1449 MKYYSAPWTYELAL-KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSIT 1507
Query 171 DWTVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
+ ++ S + + L++ R R LL+ ++ L S + V LL+A
Sbjct 1508 EIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1567
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN----------- 273
+ ++ + GM +F K D+ R F++ SL++L +A
Sbjct 1568 MLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSF---FGSLMLLFRSATGEAWQEIMLSC 1624
Query 274 ------NPDVMIPAYSKNRAYA------IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMK 321
PD P+ ++F+ F S ++NL A+I F YL +
Sbjct 1625 LGEKGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFE-YLTR 1683
Query 322 S 322
Sbjct 1684 D 1684
Score = 34.3 bits (77), Expect = 5.3, Method: Compositional matrix adjust.
Identities = 29/132 (22%), Positives = 63/132 (48%), Gaps = 15/132 (11%)
Query 135 VFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE-------- 182
VF ++ +K G + + ++LW + VV+V +LV + ++ +L ++
Sbjct 1148 VFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIK 1207
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG- 241
LR+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1208 SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKF 1267
Query 242 --KQDDGQDRER 251
D +D E+
Sbjct 1268 FYCTDSSKDTEK 1279
Score = 34.3 bits (77), Expect = 6.6, Method: Compositional matrix adjust.
Identities = 40/188 (21%), Positives = 83/188 (44%), Gaps = 17/188 (9%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P ++ ++ YF+ I L S D + +ER+ +L + VF
Sbjct 1092 NPIRKACHYIVNLRYFEMC---ILLVIAASSIALAAEDPVLTNSERNK-VLRYFDYVFTG 1147
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM++K+ GL + + F L ++ V+ + L + L + +G
Sbjct 1148 VFTFEMVIKMIDQGL---ILQDGSYFRDLWNILDFVVVVGALVAFALAN------ALGTN 1198
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY---YVFAI 595
D+ + + L V R LR + ++K + + + +V +++ IL+V ++FA+
Sbjct 1199 KGRDI-KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAV 1257
Query 596 IGINLFRG 603
I + LF+G
Sbjct 1258 IAVQLFKG 1265
>sp|O55017|CAC1B_MOUSE Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Mus musculus OX=10090 GN=Cacna1b PE=1
SV=1
Length=2327
Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust.
Identities = 139/631 (22%), Positives = 246/631 (39%), Gaps = 138/631 (22%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
G++F + +N W ++ ++VVL L L LR R+LRP L+ +
Sbjct 153 GFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---RTLRAVRVLRPLKLVSGIPSL 209
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG---------------------- 240
+ LK I ++ + +GLLL + +F + G+ + G
Sbjct 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTEPVGDFPCG 269
Query 241 ----GKQDDGQDRER---------LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
+Q DG R +T F N+ ++ ++ +T D++ Y+ N A
Sbjct 270 KDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL---YNTNDA 326
Query 288 YA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----------RGYLMKSLQTSLFRRRL 332
++FI +IGS F++NL+ ++ +F R +L Q + R
Sbjct 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELN 386
Query 333 GTRA-AFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLL 391
G F+ M+ E + + ++ L VL K+A +K R+ L+
Sbjct 387 GYLEWIFKAEEVMLAE-----EDKNAEEKSPLDVL---------KRAATKKSRND---LI 429
Query 392 SAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ-FLFGHYYFDYLGNLIALAN----- 445
AEE + F +D V R +S +S+ F F + + A
Sbjct 430 HAEEGEDRF--VDLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWV 487
Query 446 ------LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY 499
L ++CV +V +R L VF+ +L EM LK++ LG R Y
Sbjct 488 VLCVVALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRS 544
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
N FD +V + E+ A+ PG + +++L R LRI
Sbjct 545 SFNCFD-FGVIVGSIFEVVWAAI----KPG-------------TSFGISVLRALRLLRIF 586
Query 560 PSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
K + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 587 KVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF----------- 635
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK----- 671
+F Q E NFD F AA++T++ ++ +W + G SK
Sbjct 636 --------NF-QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSS 686
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
YF++ L + +N+FLA+ ++N + +
Sbjct 687 FYFIVLTLFGNYTLLNVFLAIAVDNLANAQE 717
Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 68/288 (24%), Positives = 121/288 (42%), Gaps = 53/288 (18%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGL--- 493
LA +++ C+ L L D D P +ER L FI + E +K+ ALG
Sbjct 102 LATIIANCIVLALEQHLPDGDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFVFH 157
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+G SY N ++ + VV+L ++T + +D+ R L + V
Sbjct 158 KG--SYLRNGWNVMDFVVVLTGILATAG-----------------TDFDL-RTLRAVRVL 197
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI--VALPGN 611
R L+++ + + VV +++ + + G +L +FAIIG+ + G P +
Sbjct 198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS 257
Query 612 SSLAPANGSAPC----------GSFEQLEYWA------NNFDDFAAALVTLWNLMVVNNW 655
+ P G PC G E EYW NFD+ A++T++ + + W
Sbjct 258 TDTEPV-GDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGW 316
Query 656 QVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L +G W+ +YF+ ++ S +NL L ++ F + +
Sbjct 317 TDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 364
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 59/252 (23%), Positives = 108/252 (43%), Gaps = 62/252 (25%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV-----LLVLEISTL 520
+ +L LN VF + +E +LK+ A G+ Y NVFD +TV+ +LV EI+
Sbjct 1493 ELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFD-FVTVLGSITDILVTEIANN 1551
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+ L+ L +FR R+I ++ + + VQ+ +
Sbjct 1552 FIN-----------------------LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1588
Query 581 AFGGILVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
A + +++ ++++AIIG+ +F +AL ++S+ NNF
Sbjct 1589 ALPYVCLLIAMLFFIYAIIGMQVFGN--IALDDDTSIN----------------RHNNFR 1630
Query 638 DFAAALVTLWNLMVVNNWQVFL---------DAYRRYS---GPWSKIYFVLWWLVSSVIW 685
F AL+ L+ W + D + S ++ YFV + + S +
Sbjct 1631 TFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLM 1690
Query 686 VNLFLALILENF 697
+NLF+A+I++NF
Sbjct 1691 LNLFVAVIMDNF 1702
Score = 39.3 bits (90), Expect = 0.20, Method: Compositional matrix adjust.
Identities = 65/284 (23%), Positives = 111/284 (39%), Gaps = 44/284 (15%)
Query 413 PRP--EYQSPFLQSAQFL---FGHY-----YFDYLGNLIALANLVSICVFLVLDADVLPA 462
PRP Y S F S L F HY YF+ + LV I + + A P
Sbjct 1110 PRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFE-------MVILVVIALSSIALAAEDPV 1162
Query 463 ERDDF---ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
D F L ++ +F + EM++K+ LGL L +P F L ++ ++
Sbjct 1163 RTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGL---LLHPGAYFRDLWNILDFIVVSGA 1219
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
L + +G D+ + L +L V R L+ I + + V V+ ++
Sbjct 1220 LVAFAFS------SFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1273
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN--- 634
N+ + ++ ++FA+I + LF+G S + +E+ E A
Sbjct 1274 NVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQ 1333
Query 635 ------NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
++D+ AL+TL+ + W + L DA GP
Sbjct 1334 WKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGP 1377
Score = 33.9 bits (76), Expect = 8.0, Method: Compositional matrix adjust.
Identities = 47/213 (22%), Positives = 87/213 (41%), Gaps = 35/213 (16%)
Query 135 VFAADLSVKGYLFGWAHFQKNLW-------LLGYLV-VLVVSLVDWTVSLSLVCHEPLRI 186
+F+ + +K FG ++ ++ W +LG + +LV + + ++LS LR+
Sbjct 1506 MFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSF-----LRL 1560
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R R LL+ ++ L S + V LL+A+ ++ + GM +F DD
Sbjct 1561 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1620
Query 247 QDRERLTYFQNLPESLTSLLVLLTTAN-----------------NPDVMIPAYSKNRAYA 289
R F+ L +L++L +A +P + AY
Sbjct 1621 TSINRHNNFRTF---LQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAY- 1676
Query 290 IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+F+ F + S ++NL A+I F YL +
Sbjct 1677 FYFVSFIFLCSFLMLNLFVAVIMDNFE-YLTRD 1708
>sp|Q02485|CAC1S_RAT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Rattus norvegicus OX=10116 GN=Cacna1s PE=1
SV=2
Length=1850
Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 72/304 (24%), Positives = 134/304 (44%), Gaps = 47/304 (15%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P+ ++ YF+YL + AL L +IC+ + +E+ + I ILN F
Sbjct 1104 KNPYQYQVWYVVTSSYFEYL--MFALIMLNTICLGM---QHYNQSEQMNHISDILNVAFT 1158
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPE 533
+ + LEM+LK+ A RGY P NVFD L+ + +++ EI TL
Sbjct 1159 IIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGG 1218
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF---GGILVVVY 590
+ +FR +R+I + V + + +++ +A ++V+++
Sbjct 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+++A+IG+ +F G I + G Q+ NNF F A++ L+
Sbjct 1279 FIYAVIGMQMF-GKIAMVDGT----------------QINR-NNNFQTFPQAVLLLFRCA 1320
Query 651 VVNNWQVFLDA--YRRYSGPWSK---------------IYFVLWWLVSSVIWVNLFLALI 693
WQ L A Y + P S YF+ ++++ + + +NLF+A+I
Sbjct 1321 TGEAWQEILLACSYGKRCDPESDYAPGEEYACGTNFAYYYFISFYMLCAFLIINLFVAVI 1380
Query 694 LENF 697
++NF
Sbjct 1381 MDNF 1384
Score = 66.6 bits (161), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 128/550 (23%), Positives = 218/550 (40%), Gaps = 108/550 (20%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR RLLR F + + + + + + S+ +AS+ LLL + + +F + GM LF GG+
Sbjct 527 LRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLF-GGRY 585
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA----------IFFI 293
D R + F N P++L S+ +LT + VM Y+ AY I+FI
Sbjct 586 DFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVM---YNGIMAYGGPSYPGVLVCIYFI 642
Query 294 VFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFP 352
+ V G+ L+N+ AI + S Q + R + + + E
Sbjct 643 ILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKSEEERSTMT 702
Query 353 QAVGVKPQNL-LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
+ + KP+ + K+++D + + E Y S + +E D +
Sbjct 703 KKLEQKPKGEGIPTTAKLKID-EFESNVNEVKDPYPSADFPGD------DEEDEPEIPAS 755
Query 412 P-PRP-------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS--------ICVFLVL 455
P PRP E P +++ F + F + L + + I +F++L
Sbjct 756 PRPRPLAELQLKEKAVPIPEASSF----FIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
Query 456 DADVLPAE---RDDF----ILGILNCVFIVYYLLEMLLKVFALG--------LRGYLSYP 500
+ L AE R D IL + VF + +E++LK+ G R Y
Sbjct 812 SSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYF--- 868
Query 501 SNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+ D L+ V L+ LE S ++V ++L +L V R LR
Sbjct 869 -NILDLLVVAVSLISMGLESSAISV---------------------VKILRVLRVLRPLR 906
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGNSSL 614
I K + V V + R G I++V + ++FA IG+ LF+G + S +
Sbjct 907 AINRAKGLKHVVQCVFVAI---RTIGNIVLVTTLLQFMFACIGVQLFKGKFYSCNDLSKM 963
Query 615 APANGSA-----PCGSFEQLE----YWANN---FDDFAAALVTLWNLMVVNNWQVFL--- 659
G Q+E W +N FD+ +A+++L+ + W L
Sbjct 964 TEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
Query 660 -DAYRRYSGP 668
D+ +GP
Sbjct 1024 IDSNEEDTGP 1033
Score = 63.5 bits (153), Expect = 7e-09, Method: Compositional matrix adjust.
Identities = 68/290 (23%), Positives = 127/290 (44%), Gaps = 58/290 (20%)
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+ N V + + +EML+K++ LGLR Y N FD V +LEI
Sbjct 466 VANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFD-CFVVCSGILEIL------------ 512
Query 531 RPEMVGLLSLWDMTRM-LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
L+ MT + +++L R LR+ K +++ V L+ ++R+ +L+++
Sbjct 513 ------LVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLL 566
Query 590 YY---VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
+ +FA++G+ LF G FE E +NFD+F AL+++
Sbjct 567 FLFMIIFALLGMQLFGGRY-------------------DFEDTEVRRSNFDNFPQALISV 607
Query 647 WNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ ++ +W V + Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 608 FQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNL--- 664
Query 701 WDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDE---LTERLSQHPH 747
+ + L +A + L + E+E +T++L Q P
Sbjct 665 ----AEAESLTSAQKAKAEERKRRKMSRGLPDKSEEERSTMTKKLEQKPK 710
Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 79/345 (23%), Positives = 137/345 (40%), Gaps = 62/345 (18%)
Query 411 HPPRPEY----QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
PPR + Q+P ++ + F+ + L AN V++ V+L + D + +
Sbjct 26 RPPRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPED----DNNT 81
Query 467 FILGI--LNCVFIVYYLLEMLLKVFALGL----RGYLSYPSNVFD------GLLTVVLLV 514
LG+ L F++ + +E +K+ A G YL NV D G+ T +L
Sbjct 82 LNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQ 141
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ I + G GL + L V R LR++ + + VV +++
Sbjct 142 VNIIQTNTAPMSSKG-----AGL-----DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFK 191
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGV-----------IVALPGNSSLAPA------ 617
+ + +++ + ++AIIG+ LF+G IVA N +P
Sbjct 192 AMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSG 251
Query 618 -----NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
NGS G + + +FD+F +++T++ + + W L DA
Sbjct 252 RPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDA---IGNE 308
Query 669 WSKIYFVLWWLVSSVIWVNLFLALILENFL---HKWDPRSHLQPL 710
W IYFV L+ S +NL L ++ F K R Q L
Sbjct 309 WPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
Score = 37.4 bits (85), Expect = 0.67, Method: Compositional matrix adjust.
Identities = 36/168 (21%), Positives = 82/168 (49%), Gaps = 14/168 (8%)
Query 81 VCQRTLS---FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+C R ++ FT F++LF+ + ++L + +R + + + E + + VF
Sbjct 791 LCHRIVNATWFTNFILLFILL--SSAALAAEDPIRADSMRNQ----ILEYFDYVFTAVFT 844
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRP 192
++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+LRP
Sbjct 845 VEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLRVLRP 904
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ + +K ++C+ ++ + ++ L+ + +F G+ LF G
Sbjct 905 LRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 34.7 bits (78), Expect = 4.6, Method: Compositional matrix adjust.
Identities = 32/150 (21%), Positives = 60/150 (40%), Gaps = 18/150 (12%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
R+ R++R LL + ++ L S + V LL+ + ++ + GM +F
Sbjct 1235 FRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAM 1294
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA-----------YSKNRAYAI-- 290
DG R FQ P+++ L T ++++ Y+ YA
Sbjct 1295 VDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKRCDPESDYAPGEEYACGT 1354
Query 291 -----FFIVFTVIGSLFLMNLLTAIIYSQF 315
+FI F ++ + ++NL A+I F
Sbjct 1355 NFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
>sp|Q9P0X4|CAC1I_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1I OS=Homo sapiens OX=9606 GN=CACNA1I PE=1 SV=1
Length=2223
Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 40/300 (13%)
Query 425 AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI-LGILNCVFIVYYLLE 483
Q + H FDY + LA + C+ + L+ + A + I L + N +F ++ E
Sbjct 1163 CQTIIAHKLFDY----VVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGE 1218
Query 484 MLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
M LKV +LGL + YL NV DG L V ++ + +LA +L
Sbjct 1219 MTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA---------SAGGAKILG 1269
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAII 596
+ + R+L L R + P +KL+ V L+ +++ G I+++ + +F I+
Sbjct 1270 VLRVLRLLRTLRPLRVISRAPGLKLV------VETLISSLKPIGNIVLICCAFFIIFGIL 1323
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G+ LF+G G + N S + + + NFD+ AL++L+ L + W
Sbjct 1324 GVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWV 1383
Query 657 VF----LDAYR------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
LDA PW +YF+ + L+ S +N+F+ +++ENF HK R H
Sbjct 1384 NIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-HKC--RQH 1440
Score = 68.2 bits (165), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 66/267 (25%), Positives = 121/267 (45%), Gaps = 37/267 (14%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
Y I +A LV+ V + ++ P E + IL I N VF + LEM+LK+ A GL
Sbjct 641 YFNRGIMMAILVNT-VSMGIEHHEQPEELTN-ILEICNVVFTSMFALEMILKLAAFGLFD 698
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
YL P N+FD ++ ++ + + + G LS+ R +L V +
Sbjct 699 YLRNPYNIFDSIIVIISIWEIVG--------------QADGGLSVL---RTFRLLRVLKL 741
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
+R +P+++ VV ++ + N+ F +L++ ++F+I+G+++F
Sbjct 742 VRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTV 798
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
P NFD A+VT++ ++ +W V L + PW+ +YFV
Sbjct 799 PDR---------------KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
Query 676 LWWLVSSVIWVNLFLALILENFLHKWD 702
+ + NL +A+++E F + D
Sbjct 844 ALMTFGNYVLFNLLVAILVEGFQAEGD 870
Score = 37.7 bits (86), Expect = 0.50, Method: Compositional matrix adjust.
Identities = 32/138 (23%), Positives = 66/138 (48%), Gaps = 4/138 (3%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-- 241
LR RLLR L++ +++ L + ++ +A+ +LL + + +F++ GM +F
Sbjct 730 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 789
Query 242 -KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIG 299
+ D G F +L ++ ++ +LT + V+ + +A ++F+ G
Sbjct 790 LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFG 849
Query 300 SLFLMNLLTAIIYSQFRG 317
+ L NLL AI+ F+
Sbjct 850 NYVLFNLLVAILVEGFQA 867
>sp|P27884|CAC1A_RABIT Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Oryctolagus cuniculus OX=9986 GN=CACNA1A
PE=1 SV=1
Length=2424
Score = 68.2 bits (165), Expect = 2e-10, Method: Compositional matrix adjust.
Identities = 133/648 (21%), Positives = 261/648 (40%), Gaps = 136/648 (21%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
+ E + +F + +K G+ F + +N W ++ ++VVL L L
Sbjct 134 DDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 193
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 194 ---LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMG 250
Query 241 GKQ----DDGQD--------------------------------RERLTYFQNLPESLTS 264
++G D +T F N+ ++ +
Sbjct 251 KFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLT 310
Query 265 LLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ +T D++ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 311 VFQCITMEGWTDLL---YNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF---- 363
Query 320 MKSLQTSLFRRRLGTRAAF-------EVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQL 371
+ R R+ R AF ++ + G +A V ++ V Q+
Sbjct 364 ------AKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPF 417
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG- 430
D + ++A ++K ++ LL EE + ++ + V R +S L+++ F
Sbjct 418 DGALRRATIKKSKTD---LLHPEEAEDQLADI--ASVGSPFARASIKSAKLENSSFFHKK 472
Query 431 ----HYYFDYLGN-------LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+Y + +++L L ++CV +V P DF+ +F+
Sbjct 473 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ--PEWLSDFLY-YAEFIFLGL 529
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
++ EM +K++ LG R Y N FD ++ + E+ ++ + PG
Sbjct 530 FMSEMFIKMYGLGTRPYFHSSFNCFD-CGVIIGSIFEV----IWAVIKPG---------- 574
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAII 596
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++
Sbjct 575 ---TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 631
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW- 655
G+ LF G G+ P NFD F AA++T++ ++ +W
Sbjct 632 GMQLFGG---------QFNFDEGTPPT-----------NFDTFPAAIMTVFQILTGEDWN 671
Query 656 QVFLDAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLH 699
+V D + G IYF++ L + +N+FLA+ ++N +
Sbjct 672 EVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLAN 719
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 59/249 (24%), Positives = 107/249 (43%), Gaps = 46/249 (18%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
D L + N VF + LE LLKV A G+ Y N+FD +TV+ + +I
Sbjct 1604 DNALKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFD-FVTVLGSITDIL------- 1655
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
+ + L+ L +FR R+I ++ + + VQ+ +A +
Sbjct 1656 -----------VTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1704
Query 586 ---LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+ ++++++AIIG+ +F GN + + + F+ E+ NNF F A
Sbjct 1705 CLLIAMLFFIYAIIGMQVF--------GNIGIDMEDEDSDEDEFQITEH--NNFRTFFQA 1754
Query 643 LVTLWNLMVVNNWQVFL------DAYRRYSG--------PWSKIYFVLWWLVSSVIWVNL 688
L+ L+ W + + SG ++ YFV + + S + +NL
Sbjct 1755 LMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNL 1814
Query 689 FLALILENF 697
F+A+I++NF
Sbjct 1815 FVAVIMDNF 1823
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 66/286 (23%), Positives = 118/286 (41%), Gaps = 48/286 (17%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
LA +++ C+ L L D D P +ER L FI + E +K+ ALG +
Sbjct 105 LATIIANCIVLALEQHLPDDDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFAFH 160
Query 497 L-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
SY N ++ + VV+L ++T+ +D+ R L + V R
Sbjct 161 KGSYLRNGWNVMDFVVVLTGILATVGTE-----------------FDL-RTLRAVRVLRP 202
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV--IVALPGNSS 613
L+++ + + VV +++ + + G +L +FAIIG+ + G +
Sbjct 203 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTD 262
Query 614 LAPANGSAPCGSFEQLE----------YWA--NN----FDDFAAALVTLWNLMVVNNWQV 657
APCG+ E YW NN FD+ A++T++ + + W
Sbjct 263 DIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTD 322
Query 658 FLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L SG W+ +YF+ ++ S +NL L ++ F + +
Sbjct 323 LLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 368
Score = 33.9 bits (76), Expect = 9.0, Method: Compositional matrix adjust.
Identities = 56/280 (20%), Positives = 106/280 (38%), Gaps = 41/280 (15%)
Query 413 PRPEYQSPFLQSA--------QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
P P Y S F+ S ++ YF+ + L + + L + V P
Sbjct 1226 PMPPYSSMFILSTTNPLRRLCHYILNLRYFE----MCILMVIAMSSIALAAEDPVQPNAP 1281
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
+ +L + VF + EM++K+ LGL + + F L ++ ++ L +
Sbjct 1282 RNNVLRYFDYVFTGVFTFEMVIKMIDLGL---VLHQGAYFRDLWNILDFIVVSGALVAFA 1338
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
G D+ + L V R LR + ++K + + + +V +++
Sbjct 1339 F---------TGNSKGKDIN-TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFN 1388
Query 585 ILVV---VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN------ 635
IL+V ++FA++ + LF+G S + +E+ E A +
Sbjct 1389 ILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKY 1448
Query 636 ---FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
+D+ AL+TL+ + W L DA GP
Sbjct 1449 EFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1488
>sp|Q13698|CAC1S_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Homo sapiens OX=9606 GN=CACNA1S PE=1 SV=4
Length=1873
Score = 68.2 bits (165), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 71/304 (23%), Positives = 133/304 (44%), Gaps = 47/304 (15%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P+ ++ YF+YL + AL L +IC+ + +E+ + I ILN F
Sbjct 1104 KNPYQYQVWYIVTSSYFEYL--MFALIMLNTICLGM---QHYNQSEQMNHISDILNVAFT 1158
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPE 533
+ + LEM+LK+ A RGY P NVFD L+ + +++ EI T
Sbjct 1159 IIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF---GGILVVVY 590
+ +FR +R+I + V + + +++ +A ++V+++
Sbjct 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+++A+IG+ +F G I + G Q+ NNF F A++ L+
Sbjct 1279 FIYAVIGMQMF-GKIALVDGT----------------QINR-NNNFQTFPQAVLLLFRCA 1320
Query 651 VVNNWQVFLDA--YRRYSGPWSK---------------IYFVLWWLVSSVIWVNLFLALI 693
WQ L A Y + P S YF+ ++++ + + +NLF+A+I
Sbjct 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380
Query 694 LENF 697
++NF
Sbjct 1381 MDNF 1384
Score = 62.0 bits (149), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 68/287 (24%), Positives = 127/287 (44%), Gaps = 52/287 (18%)
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
I N V + + EML+K++ LGLR Y N FD V +LEI
Sbjct 466 IANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFD-CFVVCSGILEIL------------ 512
Query 531 RPEMVGLLSLWDMTRM-LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
L+ MT + +++L R LRI K +++ V L+ ++R+ +L+++
Sbjct 513 ------LVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLL 566
Query 590 YY---VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
+ +FA++G+ LF G FE E +NFD+F AL+++
Sbjct 567 FLFIVIFALLGMQLFGGRY-------------------DFEDTEVRRSNFDNFPQALISV 607
Query 647 WNLMVVNNWQVFL-DAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHK 700
+ ++ +W + + Y GP IYF++ ++ + I +N+FLA+ ++N L +
Sbjct 608 FQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDN-LAE 666
Query 701 WDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPH 747
+ + Q + +M+ L + E + + ++L Q P
Sbjct 667 AESLTSAQKAKAEEKKRRKMSKGLPDKS---EEEKSTMAKKLEQKPK 710
Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 104/458 (23%), Positives = 191/458 (42%), Gaps = 70/458 (15%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR RLLR F + + + + + + S+ +AS+ LLL + + +F + GM LF GG+
Sbjct 527 LRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLF-GGRY 585
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA----------IFFI 293
D R + F N P++L S+ +LT + +M Y+ AY I+FI
Sbjct 586 DFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMM---YNGIMAYGGPSYPGMLVCIYFI 642
Query 294 VFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFP 352
+ V G+ L+N+ AI + S Q + + + + + E
Sbjct 643 ILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMA 702
Query 353 QAVGVKPQNL-LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
+ + KP+ + K+++D + + E Y S + +E D +
Sbjct 703 KKLEQKPKGEGIPTTAKLKID-EFESNVNEVKDPYPSADFPGD------DEEDEPEIPLS 755
Query 412 P-PRP-------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS--------ICVFLVL 455
P PRP E P +++ F + F + L + + I +F++L
Sbjct 756 PRPRPLAELQLKEKAVPIPEASSF----FIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
Query 456 DADVLPAE---RDDF----ILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFD 505
+ L AE R D IL + F + +E++LK+ G +G S+ N F+
Sbjct 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKG--SFCRNYFN 869
Query 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
L LLV+ +S +++ G + ++ ++L +L V R LR I K +
Sbjct 870 ML---DLLVVAVSLISM------GLESSAISVV------KILRVLRVLRPLRAINRAKGL 914
Query 566 AVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
V + + + + ++ ++FA IG+ LF+G
Sbjct 915 KHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
Score = 53.5 bits (127), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 82/367 (22%), Positives = 149/367 (41%), Gaps = 65/367 (18%)
Query 392 SAEEFQKLFNELDRSVVKEHPPRP-------EYQSPFLQSAQFLFGHYYFDYLGNLIALA 444
S+ + + L + + V E PRP ++P ++ + F+ + L A
Sbjct 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
Query 445 NLVSICVFLVLDADVLPAERDDFILGI--LNCVFIVYYLLEMLLKVFALGL----RGYLS 498
N V++ V+L + D + + LG+ L F++ + +E +K+ A G YL
Sbjct 64 NCVALAVYLPMPED----DNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLR 119
Query 499 YPSNVFD------GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
NV D G+ TV+L +++ + + P + GL + L V
Sbjct 120 SGWNVLDFTIVFLGVFTVILE--QVNVIQSHTAPMSS---KGAGL-----DVKALRAFRV 169
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV +++ + + +++ + ++AIIG+ LF+G
Sbjct 170 LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFI 229
Query 605 ---IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
IVA N +P NGS G + + +FD+F +++T++ +
Sbjct 230 GTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCI 289
Query 651 VVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFL---HKWDP 703
+ W L DA W IYFV L+ S +NL L ++ F K
Sbjct 290 TMEGWTDVLYWVNDA---IGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKS 346
Query 704 RSHLQPL 710
R Q L
Sbjct 347 RGTFQKL 353
Score = 35.8 bits (81), Expect = 2.1, Method: Compositional matrix adjust.
Identities = 35/168 (21%), Positives = 82/168 (49%), Gaps = 14/168 (8%)
Query 81 VCQRTLS---FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+C R ++ FT F++LF+ + ++L + +R + + + + ++ VF
Sbjct 791 LCHRIVNATWFTNFILLFILL--SSAALAAEDPIRADSMRNQ----ILKHFDIGFTSVFT 844
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRP 192
++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+LRP
Sbjct 845 VEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRP 904
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ + +K ++C+ ++ + ++ L+ + +F G+ LF G
Sbjct 905 LRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG 952
>sp|Q9Z0Y8|CAC1I_RAT Voltage-dependent T-type calcium channel
subunit alpha-1I OS=Rattus norvegicus OX=10116 GN=Cacna1i PE=1
SV=3
Length=2201
Score = 68.2 bits (165), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 78/300 (26%), Positives = 135/300 (45%), Gaps = 40/300 (13%)
Query 425 AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI-LGILNCVFIVYYLLE 483
Q + H FDY + LA + C+ + L+ + A + I L + N +F ++ E
Sbjct 1122 CQTIIAHKLFDY----VVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGE 1177
Query 484 MLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
M LKV +LGL + YL NV DG L V ++ + ++A +L
Sbjct 1178 MTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVA---------SAGGAKILG 1228
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAII 596
+ + R+L L R + P +KL+ V L+ +++ G I+++ + +F I+
Sbjct 1229 VLRVLRLLRTLRPLRVISRAPGLKLV------VETLISSLKPIGNIVLICCAFFIIFGIL 1282
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G+ LF+G G + N S + + + NFD+ AL++L+ L + W
Sbjct 1283 GVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLASKDGWV 1342
Query 657 VF----LDAYR------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
LDA PW +YF+ + L+ S +N+F+ +++ENF HK R H
Sbjct 1343 NIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-HKC--RQH 1399
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 68/280 (24%), Positives = 126/280 (45%), Gaps = 37/280 (13%)
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
++ + L G Y I +A LV+ V + ++ P E + IL I N VF + L
Sbjct 586 ETREKLRGIVDSKYFNRGIMMAILVNT-VSMGIEHHEQPEELTN-ILEICNVVFTSMFAL 643
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
EM+LK+ A GL YL P N+FD ++ ++ + + + G LS+
Sbjct 644 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG--------------QADGGLSVL- 688
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
R +L V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G+++F
Sbjct 689 --RTFRLLRVLKLVRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFG 743
Query 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
P NFD A+VT++ ++ +W V L
Sbjct 744 CKFSLRTDTGDTVPDR---------------KNFDSLLWAIVTVFQILTQEDWNVVLYNG 788
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
+ PW+ +YFV + + NL +A+++E F + D
Sbjct 789 MASTTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGD 828
Score = 37.7 bits (86), Expect = 0.59, Method: Compositional matrix adjust.
Identities = 32/138 (23%), Positives = 66/138 (48%), Gaps = 4/138 (3%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-- 241
LR RLLR L++ +++ L + ++ +A+ +LL + + +F++ GM +F
Sbjct 688 LRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS 747
Query 242 -KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-IFFIVFTVIG 299
+ D G F +L ++ ++ +LT + V+ + +A ++F+ G
Sbjct 748 LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVALMTFG 807
Query 300 SLFLMNLLTAIIYSQFRG 317
+ L NLL AI+ F+
Sbjct 808 NYVLFNLLVAILVEGFQA 825
>sp|Q2XVR7|SC4AA_TAKRU Sodium channel protein type 4 subunit alpha
A OS=Takifugu rubripes OX=31033 GN=scn4aa PE=3 SV=1
Length=1892
Score = 68.2 bits (165), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 127/632 (20%), Positives = 242/632 (38%), Gaps = 171/632 (27%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRL 189
+F ++ +K +G+ + N W ++ +SL+ + +L L + LR R
Sbjct 1113 FIFVIEMLLKWVAYGFKTYFTNAWCWLDFFIVDISLISLSANLMGFSDLGPIKSLRTLRA 1172
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--------- 240
LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1173 LRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYRCINTT 1232
Query 241 ----------GKQDDGQDRERLTY----------FQNLPESLTSLLVLLTTANNPDVMIP 280
+ D + T + N+ + SLL + T D+M P
Sbjct 1233 TAELFPISVVNNKSDCVALQEATQEARWVNVKVNYDNVAKGYLSLLQIATFKGWMDIMYP 1292
Query 281 A-----------YSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFR 329
A Y N I+F++F + GS F +NL +I F +
Sbjct 1293 AVDSREVEEQPSYEINLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ----------K 1342
Query 330 RRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSV 389
++LG + F M E+ + Y
Sbjct 1343 KKLGDKDIF----------------------------------------MTEEQKKY--- 1359
Query 390 LLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF-GHYYFDYLGNLIALANLVS 448
E +KL ++ + + PRP + +Q F F +FD ++ N+V+
Sbjct 1360 ---YEAMKKLGSKKPQKPI----PRP---ANLIQGLVFDFISQQFFDIFIMVLICLNMVT 1409
Query 449 ICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS-NVFDGL 507
+ +V D PA ++DF+ + N FIV + E LK+FAL R Y N+FD
Sbjct 1410 M---MVETDDQSPA-KEDFLFKV-NVAFIVVFTGECTLKLFAL--RHYFFTNGWNIFD-- 1460
Query 508 LTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
++++L I+ + + + P + ++ L + R+L ++ R +R + +M+
Sbjct 1461 --FIVVILSIAGTMLSDIIEKYFVSPTLFRVIRLARIGRILRLIKGARGIRTLLFALMMS 1518
Query 567 VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
+ A +GL +L ++ ++F+I G++ F V N
Sbjct 1519 LPALFNIGL---------LLFLIMFIFSIFGMSNFAYVKKEAGINDMF------------ 1557
Query 627 EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DAYRRYSGPWSKI----- 672
NF+ F ++++ L+ + W L D + P + +
Sbjct 1558 --------NFETFGSSIICLFQITTSAGWDTLLLPMLNKEPPDCDPAFENPGTDVKGNCG 1609
Query 673 -------YFVLWWLVSSVIWVNLFLALILENF 697
+F + ++S ++ VN+++A+ILENF
Sbjct 1610 NPMMGMVFFCSYIIISFLVVVNMYIAIILENF 1641
Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 55/251 (22%), Positives = 111/251 (44%), Gaps = 36/251 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + VF +++EMLLK A G + Y + D +++IS +++
Sbjct 1103 VLEFADKVFTFIFVIEMLLKWVAYGFKTYFTNAWCWLD------FFIVDISLISL----- 1151
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
++G L + + L L R LR + + M VV + ++G + ++ + +
Sbjct 1152 ---SANLMGFSDLGPI-KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCL 1207
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFE---QLEYWAN---NF 636
+ + +F+I+G+NLF G ++ ++ N + C + + Q W N N+
Sbjct 1208 IFWLIFSIMGVNLFAGKFYRCINTTTAELFPISVVNNKSDCVALQEATQEARWVNVKVNY 1267
Query 637 DDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWV 686
D+ A ++L + W + D+ P + IYFV++ + S +
Sbjct 1268 DNVAKGYLSLLQIATFKGWMDIMYPAVDSREVEEQPSYEINLYMYIYFVIFIIFGSFFTL 1327
Query 687 NLFLALILENF 697
NLF+ +I++NF
Sbjct 1328 NLFIGVIIDNF 1338
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 52/220 (24%), Positives = 102/220 (46%), Gaps = 34/220 (15%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAH-FQKNLWLLGYLVVLVVSLVDWTVS-------LSL 178
V V ++VF + ++K LF H F N W + +V+++S+ +S +S
Sbjct 1427 KVNVAFIVVFTGECTLK--LFALRHYFFTNGWNIFDFIVVILSIAGTMLSDIIEKYFVSP 1484
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + +F++FGM F
Sbjct 1485 TLFRVIRLARIGRILRLIKGARGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNF 1544
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-----NRAYA---- 289
A K++ G + + F+ S+ L + T+A +++P +K + A+
Sbjct 1545 AYVKKEAGIND--MFNFETFGSSIICLFQITTSAGWDTLLLPMLNKEPPDCDPAFENPGT 1602
Query 290 -------------IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+FF + +I L ++N+ AII F
Sbjct 1603 DVKGNCGNPMMGMVFFCSYIIISFLVVVNMYIAIILENFN 1642
Score = 37.4 bits (85), Expect = 0.65, Method: Compositional matrix adjust.
Identities = 27/91 (30%), Positives = 42/91 (46%), Gaps = 8/91 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNS+ A G P G + Y +FD F A + L+ LM +NW+
Sbjct 338 LCGNSTDA---GKCPEGYLCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDNWESLFQLT 394
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G ++FV+ + S +NL LA++
Sbjct 395 LRAAGQTYMLFFVVVIFLGSFYLINLILAVV 425
>sp|P07293|CAC1S_RABIT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Oryctolagus cuniculus OX=9986 GN=CACNA1S
PE=1 SV=1
Length=1873
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 71/304 (23%), Positives = 132/304 (43%), Gaps = 47/304 (15%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P+ ++ YF+YL + AL L +IC+ + +E + I ILN F
Sbjct 1104 KNPYQYQVWYVVTSSYFEYL--MFALIMLNTICLGM---QHYHQSEEMNHISDILNVAFT 1158
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPE 533
+ + LEM+LK+ A RGY P NVFD L+ + +++ EI T
Sbjct 1159 IIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF---GGILVVVY 590
+ +FR +R+I + V + + +++ +A ++V+++
Sbjct 1219 CGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+++A+IG+ +F G I + G Q+ NNF F A++ L+
Sbjct 1279 FIYAVIGMQMF-GKIALVDGT----------------QINR-NNNFQTFPQAVLLLFRCA 1320
Query 651 VVNNWQVFLDA--YRRYSGPWSK---------------IYFVLWWLVSSVIWVNLFLALI 693
WQ L A Y + P S YF+ ++++ + + +NLF+A+I
Sbjct 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVI 1380
Query 694 LENF 697
++NF
Sbjct 1381 MDNF 1384
Score = 57.8 bits (138), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 113/500 (23%), Positives = 190/500 (38%), Gaps = 108/500 (22%)
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---- 289
GM LF GG+ D R + F N P++L S+ +LT + VM Y+ AY
Sbjct 577 GMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVM---YNGIMAYGGPSY 632
Query 290 ------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFEVLS 342
I+FI+ V G+ L+N+ AI + S Q + R + + +
Sbjct 633 PGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPD 692
Query 343 SMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
E + + KP+ + K+++D + + E Y S + +
Sbjct 693 KTEEEKSVMAKKLEQKPKGEGIPTTAKLKVD-EFESNVNEVKDPYPSADFPGD------D 745
Query 402 ELDRSVVKEHP-PRP-------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS----- 448
E D + P PRP E P +++ F + F + L + +
Sbjct 746 EEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSF----FIFSPTNKVRVLCHRIVNATWF 801
Query 449 ---ICVFLVLDADVLPAER-------DDFILGILNCVFIVYYLLEMLLKVFALG------ 492
I +F++L + L AE + ILG + F + +E++LK+ G
Sbjct 802 TNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGAFLHKG 861
Query 493 --LRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
R Y N+ D L+ V L+ LE ST++V ++L
Sbjct 862 SFCRNYF----NILDLLVVAVSLISMGLESSTISV---------------------VKIL 896
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGV 604
+L V R LR I K + V V + R G I++V + ++FA IG+ LF+G
Sbjct 897 RVLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIVLVTTLLQFMFACIGVQLFKGK 953
Query 605 IVALPGNSSLAPANGSA-----PCGSFEQLE----YWANN---FDDFAAALVTLWNLMVV 652
+ S + G Q+E W +N FD+ +A+++L+ +
Sbjct 954 FFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTF 1013
Query 653 NNWQVFL----DAYRRYSGP 668
W L D+ GP
Sbjct 1014 EGWPQLLYRAIDSNEEDMGP 1033
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 74/334 (22%), Positives = 134/334 (40%), Gaps = 59/334 (18%)
Query 411 HPPRPEY----QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
PPR + Q+P ++ + F+ + L AN V++ V+L + D + +
Sbjct 26 RPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED----DNNS 81
Query 467 FILGI--LNCVFIVYYLLEMLLKVFALGL----RGYLSYPSNVFD------GLLTVVLLV 514
LG+ L F+ + +E +K+ A G YL NV D G+ T +L
Sbjct 82 LNLGLEKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQ 141
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ + + G GL + L V R LR++ + + VV +++
Sbjct 142 VNVIQSNTAPMSSKG-----AGL-----DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFK 191
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGV-----------IVALPGNSSLAPA------ 617
+ + +++ + ++AIIG+ LF+G IVA N +P
Sbjct 192 AMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSG 251
Query 618 -----NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
NGS G + + +FD+F +++T++ + + W L DA
Sbjct 252 RPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDA---IGNE 308
Query 669 WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
W IYFV L+ S +NL L ++ F + +
Sbjct 309 WPWIYFVTLILLGSFFILNLVLGVLSGEFTKERE 342
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 65/269 (24%), Positives = 115/269 (43%), Gaps = 58/269 (22%)
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
I N V + + +EMLLK++ LGLR Y N FD V +LE+
Sbjct 466 IANRVLLSLFTIEMLLKMYGLGLRQYFMSIFNRFD-CFVVCSGILELL------------ 512
Query 531 RPEMVGLLSLWDMTRM-LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGIL 586
L+ MT + +++L R LR+ K +++ V L+ ++R + +L
Sbjct 513 ------LVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLL 566
Query 587 VVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
+ +FA++G+ LF G FE E +NFD+F AL+++
Sbjct 567 FLFIIIFALLGMQLFGGRY-------------------DFEDTEVRRSNFDNFPQALISV 607
Query 647 WNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLH- 699
+ ++ +W V + Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 608 FQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEA 667
Query 700 ---------KWDPRSHLQPLAGTPEATYQ 719
K + R + G P+ T +
Sbjct 668 ESLTSAQKAKAEERKRRKMSRGLPDKTEE 696
Score = 36.2 bits (82), Expect = 1.6, Method: Compositional matrix adjust.
Identities = 35/168 (21%), Positives = 81/168 (48%), Gaps = 14/168 (8%)
Query 81 VCQRTLS---FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+C R ++ FT F++LF+ + ++L + +R + + + ++ VF
Sbjct 791 LCHRIVNATWFTNFILLFILL--SSAALAAEDPIRAESVRNQ----ILGYFDIAFTSVFT 844
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRP 192
++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+LRP
Sbjct 845 VEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLRVLRP 904
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ + +K ++C+ ++ + ++ L+ + +F G+ LF G
Sbjct 905 LRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
>sp|P97445|CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Mus musculus OX=10090 GN=Cacna1a PE=1
SV=2
Length=2368
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 133/648 (21%), Positives = 262/648 (40%), Gaps = 136/648 (21%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
+ E + +F + +K G+ F + +N W ++ ++VVL L L
Sbjct 136 DDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 195
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 196 ---LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMG 252
Query 241 GKQ----DDGQD--------------------------------RERLTYFQNLPESLTS 264
++G D +T F N+ ++ +
Sbjct 253 KFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLT 312
Query 265 LLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ +T D++ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 313 VFQCITMEGWTDLL---YNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF---- 365
Query 320 MKSLQTSLFRRRLGTRAAF-------EVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQL 371
+ R R+ R AF ++ + G +A V ++ V Q+
Sbjct 366 ------AKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPF 419
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG- 430
D + ++A ++K ++ LL+ EE + ++ + V R +S L+++ F
Sbjct 420 DGALRRATLKKSKT---DLLNPEEAEDQLADI--ASVGSPFARASIKSAKLENSTFFHKK 474
Query 431 ----HYYFDYLGN-------LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+Y + +++L L ++CV +V P DF+ +F+
Sbjct 475 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ--PEWLSDFLY-YAEFIFLGL 531
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
++ EM +K++ LG R Y N FD ++ + E+ ++ + PG
Sbjct 532 FMSEMFIKMYGLGTRPYFHSSFNCFD-CGVIIGSIFEV----IWAVIKPG---------- 576
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAII 596
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++
Sbjct 577 ---TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALL 633
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW- 655
G+ LF G G+ P NFD F AA++T++ ++ +W
Sbjct 634 GMQLFGG---------QFNFDEGTPPT-----------NFDTFPAAIMTVFQILTGEDWN 673
Query 656 QVFLDAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLH 699
+V D + G IYF++ L + +N+FLA+ ++N +
Sbjct 674 EVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLAN 721
Score = 50.8 bits (120), Expect = 5e-05, Method: Compositional matrix adjust.
Identities = 66/286 (23%), Positives = 119/286 (42%), Gaps = 48/286 (17%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
LA +++ C+ L L D D P +ER L FI + E +K+ ALG +
Sbjct 107 LATIIANCIVLALEQHLPDDDKTPMSER----LDDTEPYFIGIFCFEAGIKIVALGFAFH 162
Query 497 L-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
SY N ++ + VV+L ++T+ + +D+ R L + V R
Sbjct 163 KGSYLRNGWNVMDFVVVLTGILATVG-----------------TEFDL-RTLRAVRVLRP 204
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV--IVALPGNSS 613
L+++ + + VV +++ + + G +L +FAIIG+ + G +
Sbjct 205 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTD 264
Query 614 LAPANGSAPCGSFEQLE----------YW--ANN----FDDFAAALVTLWNLMVVNNWQV 657
APCG+ E YW NN FD+ A++T++ + + W
Sbjct 265 DIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTD 324
Query 658 FLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L SG W+ +YF+ ++ S +NL L ++ F + +
Sbjct 325 LLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 370
Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 57/246 (23%), Positives = 106/246 (43%), Gaps = 46/246 (19%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L + N VF + LE +LKV A G+ Y N+FD +TV+ + +I
Sbjct 1549 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD-FVTVLGSITDIL---------- 1597
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI--- 585
+ + L+ L +FR R+I ++ + + VQ+ +A +
Sbjct 1598 --------VTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1649
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++++AIIG+ +F GN + + + F+ E+ NNF F AL+
Sbjct 1650 IAMLFFIYAIIGMQVF--------GNIGIDGEDEDSDEDEFQITEH--NNFRTFFQALML 1699
Query 646 LWNLMVVNNWQVFL------DAYRRYSG--------PWSKIYFVLWWLVSSVIWVNLFLA 691
L+ W + + SG ++ YFV + + S + +NLF+A
Sbjct 1700 LFRSATGEAWHNIMLSCLSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVA 1759
Query 692 LILENF 697
+I++NF
Sbjct 1760 VIMDNF 1765
>sp|Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Homo sapiens OX=9606 GN=CACNA1E PE=1 SV=3
Length=2313
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 147/664 (22%), Positives = 264/664 (40%), Gaps = 174/664 (26%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E + +F + +K G++F + +N W ++ ++VVL S + T
Sbjct 125 EKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL--SGILATAGTHFNT 182
Query 181 H---EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
H LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+
Sbjct 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query 238 FAGGKQD----------DGQD----------------------RERLTYFQNLPESLTSL 265
++G +G D + +T F N+ ++ ++
Sbjct 243 YSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTV 302
Query 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
+T V+ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 303 FQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 359
Query 316 -----RGYLMKSLQTSLFRRRLGTRA----AFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
R ++ Q + R G RA A EV+ + + + L+VL
Sbjct 360 RVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAG---------TSALEVL 410
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
++ + S +AM V +S+ + L R+ +K SA+
Sbjct 411 RRATIKRSRTEAMTRDSSDEHCVDISS-----VGTPLARASIK--------------SAK 451
Query 427 FLFGHYYFDYLGNL--IALANLVSICVF--LVLDADVLPAERDDFILGILNCVFIVYY-- 480
+ G YF + L I++ ++V VF +VL L CV IV++
Sbjct 452 -VDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTA----------CVAIVHHNQ 500
Query 481 -------------------LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
LLEM LK++ +G R Y N FD +TV + E+ A
Sbjct 501 PQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS-IFEV-VWA 558
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
++R PG + +++L R LRI K A + + V+ L+ +M++
Sbjct 559 IFR---PG-------------TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKS 602
Query 582 FGGILVVVYYVF---AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
+L +++ A++G+ LF G G S NFD
Sbjct 603 IISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA--------------------NFDT 642
Query 639 FAAALVTLWNLMVVNNW-QVFLDAYRRY----SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
F AA++T++ ++ +W +V + R SG WS IYF++ L + +N+FLA+
Sbjct 643 FPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIA 702
Query 694 LENF 697
++N
Sbjct 703 VDNL 706
Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 57/254 (22%), Positives = 101/254 (40%), Gaps = 56/254 (22%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ L LN F + + LE +LKV A G Y N+FD +TV+ + EI +
Sbjct 1507 ELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD-FITVIGSITEIILTDSKLV 1565
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G+ ++ L +FR R+I ++ + + VQ+ +A +
Sbjct 1566 NTSGFN---------------MSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1610
Query 586 LVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+++ ++++AIIG+ +F GN L E NNF F +
Sbjct 1611 CLLIAMLFFIYAIIGMQVF--------GNIKLDE----------ESHINRHNNFRSFFGS 1652
Query 643 LVTLWNLMVVNNWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSV 683
L+ L+ WQ + + R + +YFV + S
Sbjct 1653 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSF 1712
Query 684 IWVNLFLALILENF 697
+ +NLF+A+I++NF
Sbjct 1713 LMLNLFVAVIMDNF 1726
Score = 43.1 bits (100), Expect = 0.011, Method: Compositional matrix adjust.
Identities = 63/287 (22%), Positives = 120/287 (42%), Gaps = 46/287 (16%)
Query 434 FDYLGNLIALANLVSICVFLVLDA-----DVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
F+Y+ LA +++ C+ L L+ D P R L FI + E +K+
Sbjct 91 FEYM----ILATIIANCIVLALEQHLPEDDKTPMSRR---LEKTEPYFIGIFCFEAGIKI 143
Query 489 FALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
ALG +G SY N ++ + +V+L ++T + H V L R
Sbjct 144 VALGFIFHKG--SYLRNGWNVMDFIVVLSGILATAGTHFNTH-------VDL-------R 187
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + V R L+++ + + +V +++ + + G +L +FAIIG+ + G +
Sbjct 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query 606 --VALPGNSSLAPA-NGSAPCG------SFEQLEYWANN-----FDDFAAALVTLWNLMV 651
NS + + PCG +E ++ N FD+ A++T++ +
Sbjct 248 HRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query 652 VNNWQVFL-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W L + W+ +YF+ ++ S +NL L ++ F
Sbjct 308 MEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 354
Score = 37.4 bits (85), Expect = 0.75, Method: Compositional matrix adjust.
Identities = 46/237 (19%), Positives = 96/237 (41%), Gaps = 36/237 (15%)
Query 118 WEPPCGLTESVEVLCL---LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV 174
+ PC +++ L + +VF+ + +K FG+ ++ ++ W + + ++ S+ + +
Sbjct 1500 YSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIIL 1559
Query 175 SLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
+ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1560 TDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1619
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN--------------- 273
++ + GM +F K D+ R F++ SL++L +A
Sbjct 1620 IYAIIGMQVFGNIKLDEESHINRHNNFRSF---FGSLMLLFRSATGEAWQEIMLSCLGEK 1676
Query 274 --NPDVMIPAYSKNRAYA------IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
PD P+ ++F+ F S ++NL A+I F YL +
Sbjct 1677 GCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFE-YLTRD 1732
Score = 34.3 bits (77), Expect = 5.4, Method: Compositional matrix adjust.
Identities = 26/120 (22%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query 143 KGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE--------PLRIRRLLRPFF 194
+G + + ++LW + VV+V +LV + ++ +L ++ LR+ R+LRP
Sbjct 1208 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1267
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG---KQDDGQDRER 251
++ +K C+ SL + ++ ++ + + +F + + LF G D +D E+
Sbjct 1268 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1327
Score = 34.3 bits (77), Expect = 5.8, Method: Compositional matrix adjust.
Identities = 33/148 (22%), Positives = 68/148 (46%), Gaps = 13/148 (9%)
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIS 518
VL + +L + VF + EM++K+ GL + + F L ++ V+ +
Sbjct 1176 VLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGL---ILQDGSYFRDLWNILDFVVVVG 1232
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
L + L + +G D+ + + L V R LR + ++K + + + +V +
Sbjct 1233 ALVAFALAN------ALGTNKGRDI-KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTS 1285
Query 579 MRAFGGILVVVY---YVFAIIGINLFRG 603
++ IL+V ++FA+I + LF+G
Sbjct 1286 LKNVFNILIVYKLFMFIFAVIAVQLFKG 1313
>sp|Q00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Homo sapiens OX=9606 GN=CACNA1B PE=1 SV=1
Length=2339
Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust.
Identities = 138/632 (22%), Positives = 251/632 (40%), Gaps = 140/632 (22%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
G++F + +N W ++ ++VVL L L LR R+LRP L+ +
Sbjct 153 GFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---RTLRAVRVLRPLKLVSGIPSL 209
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG---------------------G 241
+ LK I ++ + +GLLL + +F + G+ + G G
Sbjct 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query 242 KQ-------DDGQDRE-------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
K+ D + RE +T F N+ ++ ++ +T D++ Y+ N A
Sbjct 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL---YNTNDA 326
Query 288 YA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----------RGYLMKSLQTSLFRRRL 332
++FI +IGS F++NL+ ++ +F R +L Q + R
Sbjct 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELN 386
Query 333 GTRA-AFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLL 391
G F+ M+ E + + ++ L VL K+A +K R+ L+
Sbjct 387 GYLEWIFKAEEVMLAE-----EDRNAEEKSPLDVL---------KRAATKKSRND---LI 429
Query 392 SAEEFQKLFNEL-------DRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGN----- 439
AEE + F +L R+ +K S + + + +F + +
Sbjct 430 HAEEGEDRFADLCAVGSPFARASLKSGKTE---SSSYFRRKEKMFRFFIRRMVKAQSFYW 486
Query 440 -LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLS 498
++ + L ++CV +V R L VF+ +L EM LK++ LG R Y
Sbjct 487 VVLCVVALNTLCVAMV---HYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFR 543
Query 499 YPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N FD +V V E+ A+ PG + +++L R LRI
Sbjct 544 SSFNCFD-FGVIVGSVFEVVWAAI----KPG-------------SSFGISVLRALRLLRI 585
Query 559 IPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
K + + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 586 FKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF---------- 635
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK---- 671
+F Q E NFD F AA++T++ ++ +W + G SK
Sbjct 636 ---------NF-QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS 685
Query 672 -IYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
YF++ L + +N+FLA+ ++N + +
Sbjct 686 SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQE 717
Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 70/287 (24%), Positives = 122/287 (43%), Gaps = 51/287 (18%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGL--- 493
LA +++ C+ L L D D P +ER L FI + E +K+ ALG
Sbjct 102 LATIIANCIVLALEQHLPDGDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFVFH 157
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+G SY N ++ + VV+L ++T + +D+ R L + V
Sbjct 158 KG--SYLRNGWNVMDFVVVLTGILATAG-----------------TDFDL-RTLRAVRVL 197
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-VALPGNS 612
R L+++ + + VV +++ + + G +L +FAIIG+ + G A NS
Sbjct 198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS 257
Query 613 SLAPANGSAPCGS----------FEQLEYWA------NNFDDFAAALVTLWNLMVVNNWQ 656
+ A G PCG E EYW NFD+ A++T++ + + W
Sbjct 258 TDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWT 317
Query 657 VFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L +G W+ +YF+ ++ S +NL L ++ F + +
Sbjct 318 DILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 364
Score = 50.8 bits (120), Expect = 5e-05, Method: Compositional matrix adjust.
Identities = 56/247 (23%), Positives = 109/247 (44%), Gaps = 50/247 (20%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ +L LN VF + +E +LK+ A G+ Y NVFD +TV+ + +I
Sbjct 1500 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD-FVTVLGSITDI-------- 1550
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
+V ++ + L+ L +FR R+I ++ + + VQ+ +A +
Sbjct 1551 --------LVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1602
Query 586 LVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+++ ++++AIIG+ +F +AL ++S+ NNF F A
Sbjct 1603 CLLIAMLFFIYAIIGMQVFGN--IALDDDTSIN----------------RHNNFRTFLQA 1644
Query 643 LVTLWNLMVVNNW-QVFLDAYRRYS-----------GPWSKIYFVLWWLVSSVIWVNLFL 690
L+ L+ W ++ L + ++ YFV + + S + +NLF+
Sbjct 1645 LMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFV 1704
Query 691 ALILENF 697
A+I++NF
Sbjct 1705 AVIMDNF 1711
Score = 41.2 bits (95), Expect = 0.051, Method: Compositional matrix adjust.
Identities = 69/305 (23%), Positives = 124/305 (41%), Gaps = 40/305 (13%)
Query 387 GSVLLSAEEFQKLFNELDRSVVKEHPPRP--EYQSPFLQSAQFL---FGHY-----YFDY 436
G+V L ++ K E++ V PRP Y S F S L F HY YF+
Sbjct 1097 GNVDLESQAEGK--KEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEV 1154
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + L SI L + V + L L+ +F + EM++K+ LGL
Sbjct 1155 V--ILVVIALSSIA--LAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGL--- 1207
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L +P F L ++ ++ L + G + + + + + L +L V R L
Sbjct 1208 LLHPGAYFRDLWNILDFIVVSGALVAFAFS--GSKGKDINTI------KSLRVLRVLRPL 1259
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
+ I + + V V+ ++N+ + ++ ++FA+I + LF+G S
Sbjct 1260 KTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1319
Query 617 ANGSAPCGSFEQLEYWAN---------NFDDFAAALVTLWNLMVVNNWQVFL----DAYR 663
+ +E+ E A ++D+ AL+TL+ + W + L DA
Sbjct 1320 RDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1379
Query 664 RYSGP 668
GP
Sbjct 1380 EEQGP 1384
Score = 34.3 bits (77), Expect = 6.0, Method: Compositional matrix adjust.
Identities = 54/194 (28%), Positives = 91/194 (47%), Gaps = 14/194 (7%)
Query 128 VEVLCLLVFAADLSVKGYLFG-WAHFQK--NLWLLGYLVVLVVSLVDWTV--SLSLVCHE 182
E + L +F ++S+K Y G ++F+ N + G +V V +V W S
Sbjct 517 AEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVV-WAAIKPGSSFGIS 575
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR RLLR F + + S ++ + + S+ + S+ LL + + +F + GM LF G
Sbjct 576 VLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG-- 633
Query 243 QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------AYSKNRAYAIFFIVFT 296
Q + QD T F P ++ ++ +LT + VM SK + +FIV T
Sbjct 634 QFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLT 693
Query 297 VIGSLFLMNLLTAI 310
+ G+ L+N+ AI
Sbjct 694 LFGNYTLLNVFLAI 707
>sp|Q2XVR4|SC4AB_TETNG Sodium channel protein type 4 subunit alpha
B OS=Tetraodon nigroviridis OX=99883 GN=scn4ab PE=3 SV=1
Length=1715
Score = 67.4 bits (163), Expect = 4e-10, Method: Compositional matrix adjust.
Identities = 133/599 (22%), Positives = 253/599 (42%), Gaps = 107/599 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
VF ++ +K + +G+ + N W +++ VSLV T ++ L + LR R L
Sbjct 958 VFVVEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGYSELGAIKSLRTLRAL 1017
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG +
Sbjct 1018 RPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCLIFWLIFSIMGVNLFAGKFSYCFNETS 1077
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ + + + + T + L+ AN +V N IG L L+ + T
Sbjct 1078 QEQFDKKIVNNKTECIALIE-ANFTEVRWKNLKVNYDNV-------GIGYLSLLQVAT-- 1127
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
F+G+ M+ + ++ R + ++ +EV M + G F L
Sbjct 1128 ----FKGW-MEIMYAAVDSRDVESQPIYEVNIYMYLYFVIFIIFGSFFT----------L 1172
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQSP 420
+ V +D+ ++Q K + G + EE +K +N + + S + P PRPE
Sbjct 1173 NLFIGVIIDNFNQQ----KAKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPENA-- 1226
Query 421 FLQSAQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
LQ F L FD ++ N+V+ ++++ D E++D IL +N +FIV
Sbjct 1227 -LQGLVFDLVTKQIFDVFIMVLICLNMVT----MMVETDEQTKEKED-ILYWINVIFIVI 1280
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK AL R Y S NVFD V+++L I L + + + P + ++
Sbjct 1281 FTTECILKTIALR-RHYFSIGWNVFD----FVVVILSILGLLLADIIEKYFVSPTLFRVI 1335
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M++ A +GL +L ++ ++F+I G+
Sbjct 1336 RLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLIMFIFSIFGM 1386
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V E + NF+ F +++ L+ + W
Sbjct 1387 SNFAYV--------------------KKEAMIDDMFNFETFGNSMICLFMITTSAGWDGL 1426
Query 659 L--------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILENF 697
L D P + ++F + ++S ++ VN+++A+ILENF
Sbjct 1427 LSPIMNKPPDCDPDLENPGTTVRGNCGSPAIGIVFFSTYIIMSFLVVVNMYIAIILENF 1485
Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 62/252 (25%), Positives = 109/252 (43%), Gaps = 37/252 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF +++EM+LK FA G + Y S D L+ V LV + + Y
Sbjct 947 ILEYADKVFTYVFVVEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGYS--- 1003
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
E+ + SL R L L R LR + + M VV + ++G V ++ + +
Sbjct 1004 -----ELGAIKSL----RTLRAL---RPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCL 1051
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAP-----ANGSAPCGSFEQLEY----WAN---N 635
+ + +F+I+G+NLF G +S N C + + + W N N
Sbjct 1052 IFWLIFSIMGVNLFAGKFSYCFNETSQEQFDKKIVNNKTECIALIEANFTEVRWKNLKVN 1111
Query 636 FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIW 685
+D+ ++L + W + D+ S P + +YFV++ + S
Sbjct 1112 YDNVGIGYLSLLQVATFKGWMEIMYAAVDSRDVESQPIYEVNIYMYLYFVIFIIFGSFFT 1171
Query 686 VNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1172 LNLFIGVIIDNF 1183
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 49/218 (22%), Positives = 99/218 (45%), Gaps = 33/218 (15%)
Query 128 VEVLCLLVFAADLSVKG-------YLFGWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLV 179
+ V+ +++F + +K + GW F + +L L +L+ +++ + VS +L
Sbjct 1273 INVIFIVIFTTECILKTIALRRHYFSIGWNVFDFVVVILSILGLLLADIIEKYFVSPTL- 1331
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + +F++FGM FA
Sbjct 1332 -FRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFA 1390
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA--------------------NNPDVMI 279
K++ D + F+ S+ L ++ T+A NP +
Sbjct 1391 YVKKEAMID--DMFNFETFGNSMICLFMITTSAGWDGLLSPIMNKPPDCDPDLENPGTTV 1448
Query 280 PAYSKNRAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ A I FF + ++ L ++N+ AII F
Sbjct 1449 RGNCGSPAIGIVFFSTYIIMSFLVVVNMYIAIILENFN 1486
Score = 41.2 bits (95), Expect = 0.050, Method: Compositional matrix adjust.
Identities = 33/162 (20%), Positives = 78/162 (48%), Gaps = 30/162 (19%)
Query 447 VSICV-----FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS 501
++IC+ F+ ++ + A+ ++ +L + N VF + EM+LK+ A+ Y
Sbjct 521 ITICIILNTIFMAMEHYPMSADFEE-LLSVGNLVFTGIFTCEMVLKILAMDPYFYFQVGW 579
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRII 559
N+FD ++ + LV +GL ++ ++ R ++ VF+ +
Sbjct 580 NIFDSIIVTMSLV-------------------ELGLANVQGLSVLRSFRLMRVFKLAKSW 620
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 621 PTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 659
>sp|Q6QIY3|SCNAA_MOUSE Sodium channel protein type 10 subunit
alpha OS=Mus musculus OX=10090 GN=Scn10a PE=1 SV=2
Length=1958
Score = 67.4 bits (163), Expect = 5e-10, Method: Compositional matrix adjust.
Identities = 125/609 (21%), Positives = 251/609 (41%), Gaps = 107/609 (18%)
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLVCH- 181
E + + +F ++ +K +G+ + N W L +L+V + SL+ + S V
Sbjct 1188 EYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASI 1247
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1248 KALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG- 1306
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSL 301
R ++ P S+ + + ++ Y++N F++ V
Sbjct 1307 ------KFSRCVDTRSNPFSVVNSTFVTNKSD-------CYNQNNTGHFFWVNVKVNFDN 1353
Query 302 FLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQA 354
M L + + F+G+ M + ++ R + ++ +E M + GG F
Sbjct 1354 VAMGYLALLQVATFKGW-MDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGGFF--- 1409
Query 355 VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR 414
L + V +D+ ++Q K + G + EE +K +N + + K+ P+
Sbjct 1410 -------TLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKK--PQ 1456
Query 415 PEYQSPFLQSAQFLFG---HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGI 471
P + F+F FD + ++AL L I + + D +E +LG
Sbjct 1457 KPIPRPLNKYQGFVFDIVTRQAFDII--IMALICLNMITMMVETDNQ---SEEKTKVLGR 1511
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTL---AVYRLPHP 528
+N F+ + E ++K+FAL + Y + NVFD ++++L IS+L A+
Sbjct 1512 INQFFVAVFTGECVMKMFAL-RQYYFTNGWNVFD----FIVVILSISSLLFSAILSSLES 1566
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
+ P ++ ++ L + R+L ++ + +R + +M++ A +GL +L +
Sbjct 1567 YFSPTLLRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGL---------LLFL 1617
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
V ++++I G+ F VI + NF F +++ L+
Sbjct 1618 VMFIYSIFGMASFANVIDEAGIDDMF--------------------NFKTFGNSMLCLFQ 1657
Query 649 LMVVNNWQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNL 688
+ W L P+ ++F + ++S +I VN+
Sbjct 1658 ITTSAGWDGLLSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFLIVVNM 1717
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1718 YIAVILENF 1726
Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 63/264 (24%), Positives = 105/264 (40%), Gaps = 66/264 (25%)
Query 472 LNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
L F V Y E L+K+ A G YL P N D +V L +
Sbjct 156 LEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLD--------------FSVITLAY 201
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
G ++ G+ L R +L + + +IP +K++ V L+ ++R + +
Sbjct 202 VGAAIDLRGISGL----RTFRVLRALKTVSVIPGLKVI------VGALIHSVRKLADVTI 251
Query 588 VVYY---VFAIIGINLFRGV-------------------------IVALPGNSS-LAPAN 618
+ + VFA++G+ LF+G I PG + L N
Sbjct 252 LTVFCLSVFALVGLQLFKGNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTTDPLLCGN 311
Query 619 GS--APC-------GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
GS C + + ++ +FD FA A ++L+ LM ++W+ R SG
Sbjct 312 GSDAGHCPNDYVCRKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKM 371
Query 670 SKIYFVLWWLVSSVIWVNLFLALI 693
++FVL + S VNL LA++
Sbjct 372 YMVFFVLVIFLGSFYLVNLILAVV 395
Score = 47.4 bits (111), Expect = 5e-04, Method: Compositional matrix adjust.
Identities = 56/252 (22%), Positives = 100/252 (40%), Gaps = 37/252 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + VF ++ EMLLK A G + Y + D L+ + L I+ + Y
Sbjct 1186 VLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEY---- 1241
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
S + L L R LR + + M VV ++G + ++ + +
Sbjct 1242 -----------SDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCL 1290
Query 588 VVYYVFAIIGINLFRGVIVALPG---------NSSLAPANGSAPCGSFEQLEYWAN---N 635
+ + +F+I+G+NLF G NS+ + +W N N
Sbjct 1291 IFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFFWVNVKVN 1350
Query 636 FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP-WSK-----IYFVLWWLVSSVIW 685
FD+ A + L + W + D+ S P W + +YFV++ +
Sbjct 1351 FDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGGFFT 1410
Query 686 VNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1411 LNLFVGVIIDNF 1422
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 36/135 (27%), Positives = 63/135 (47%), Gaps = 20/135 (15%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
D +L N VF V++ +EM K+ A Y N+FD ++ V L LE+ST
Sbjct 693 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSL-LELST------ 745
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G LS+ R +L VF+ + P++ ++ + +G + N+ I
Sbjct 746 -------SKKGSLSVL---RTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTF---I 792
Query 586 LVVVYYVFAIIGINL 600
L ++ ++FA++G L
Sbjct 793 LAIIVFIFALVGKQL 807
>sp|Q02343|CAC1E_RABIT Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Oryctolagus cuniculus OX=9986 GN=CACNA1E
PE=2 SV=1
Length=2259
Score = 67.4 bits (163), Expect = 5e-10, Method: Compositional matrix adjust.
Identities = 148/666 (22%), Positives = 265/666 (40%), Gaps = 178/666 (27%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E + +F + +K G++F + +N W ++ ++VVL S + T
Sbjct 125 EKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL--SGILATAGTHFNT 182
Query 181 H---EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
H LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+
Sbjct 183 HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEF 242
Query 238 FAGGKQD----------DGQD----------------------RERLTYFQNLPESLTSL 265
++G +G D + +T F N+ ++ ++
Sbjct 243 YSGKLHRACFVNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTV 302
Query 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
+T V+ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 303 FQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 359
Query 316 -----RGYLMKSLQTSLFRRRLGTRA----AFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
R ++ Q + R G RA A EV+ + + + L+VL
Sbjct 360 RVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNSG---------TSALEVL 410
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
++ + S +AM V +S+ + L R+ +K SA+
Sbjct 411 RRATIKRSRTEAMTRDSSDEHCVDISS-----VGTPLARASIK--------------SAK 451
Query 427 FLFGHYYFDYLGNL--IALANLVSICVF--LVLDADVLPAERDDFILGILN--CVFIVYY 480
+ G YF + L I++ + V VF +VL L LN CV IV++
Sbjct 452 -VDGASYFRHKERLLRISVRHAVKSQVFYWIVLS------------LVALNTACVAIVHH 498
Query 481 ---------------------LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
LLEM LK++ +G R Y N FD +TV + E+
Sbjct 499 NQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGS-IFEV-V 556
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
A++R PG + +++L R LRI K A + + V+ L+ +M
Sbjct 557 WAIFR---PG-------------TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM 600
Query 580 RAFGGILVVVYYVF---AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNF 636
++ +L +++ A++G+ LF G G S NF
Sbjct 601 KSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA--------------------NF 640
Query 637 DDFAAALVTLWNLMVVNNW-QVFLDAYRRY----SGPWSKIYFVLWWLVSSVIWVNLFLA 691
D F AA++T++ ++ +W +V + R SG WS +YF++ L + +N+FLA
Sbjct 641 DTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAVYFIVLTLFGNYTLLNVFLA 700
Query 692 LILENF 697
+ ++N
Sbjct 701 IAVDNL 706
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 57/254 (22%), Positives = 100/254 (39%), Gaps = 56/254 (22%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ L LN F + + LE +LKV A G Y N+FD +TV+ + EI +
Sbjct 1497 ELALKYLNIAFTMVFSLECVLKVIAFGFVNYFRDTWNIFD-FITVIGSITEIVLTDSKLV 1555
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G+ ++ L +FR R+I ++ + + VQ+ +A +
Sbjct 1556 NTTGFN---------------MSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV 1600
Query 586 LVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
+++ ++++AIIG+ +F GN L E NNF F +
Sbjct 1601 CLLIAMLFFIYAIIGMQVF--------GNIRLDE----------ESHINRHNNFRSFFGS 1642
Query 643 LVTLWNLMVVNNWQVFL-------------------DAYRRYSGPWSKIYFVLWWLVSSV 683
L+ L+ WQ + R + +YFV + S
Sbjct 1643 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSF 1702
Query 684 IWVNLFLALILENF 697
+ +NLF+A+I++NF
Sbjct 1703 LMLNLFVAVIMDNF 1716
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 63/292 (22%), Positives = 122/292 (42%), Gaps = 46/292 (16%)
Query 434 FDYLGNLIALANLVSICVFLVLDA-----DVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
F+Y+ LA +++ C+ L L+ D P R L FI + E +K+
Sbjct 91 FEYM----ILATIIANCIVLALEQHLPEDDKTPMSRR---LEKTEPYFIGIFCFEAGIKI 143
Query 489 FALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
ALG +G SY N ++ + +V+L ++T + H V L R
Sbjct 144 VALGFIFHKG--SYLRNGWNVMDFIVVLSGILATAGTHFNTH-------VDL-------R 187
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + V R L+++ + + +V +++ + + G +L +FAIIG+ + G +
Sbjct 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query 606 --VALPGNSSLAPA-NGSAPCG------SFEQLEYWANN-----FDDFAAALVTLWNLMV 651
NS + + PCG +E ++ N FD+ A++T++ +
Sbjct 248 HRACFVNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCIT 307
Query 652 VNNWQVFL-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
+ W L + W+ +YF+ ++ S +NL L ++ F + +
Sbjct 308 MEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 359
Score = 37.4 bits (85), Expect = 0.77, Method: Compositional matrix adjust.
Identities = 45/237 (19%), Positives = 97/237 (41%), Gaps = 36/237 (15%)
Query 118 WEPPCGLTESVEVLCL---LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV 174
+ PC +++ L + +VF+ + +K FG+ ++ ++ W + + ++ S+ + +
Sbjct 1490 YSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFVNYFRDTWNIFDFITVIGSITEIVL 1549
Query 175 SLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
+ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1550 TDSKLVNTTGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1609
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN--------------- 273
++ + GM +F + D+ R F++ SL++L +A
Sbjct 1610 IYAIIGMQVFGNIRLDEESHINRHNNFRSF---FGSLMLLFRSATGEAWQEIMLSCLGEK 1666
Query 274 --NPDVMIPAYSKNRAYA------IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
PD P+ + ++F+ F S ++NL A+I F YL +
Sbjct 1667 GCEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFE-YLTRD 1722
Score = 37.4 bits (85), Expect = 0.79, Method: Compositional matrix adjust.
Identities = 48/226 (21%), Positives = 95/226 (42%), Gaps = 33/226 (15%)
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG-----HYYFDYLGNLIALANLVSI 449
E ++ E ++ KE P + P S+ F+F Y+ NL +
Sbjct 1094 EMKEAEQETEKQKKKERPASGKAMVP--HSSMFIFSTSNPIRRACHYVVNL----RYFEM 1147
Query 450 CVFLVL---------DADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
C+ LV+ + VL + +L + VF + EM++K+ GL +
Sbjct 1148 CILLVIAASSIALAAEDPVLTNSERNRVLRYFDYVFTGVFTFEMVIKMIDQGL---ILQD 1204
Query 501 SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
+ F L ++ V+ + L + L + +G D+ + + L V R LR +
Sbjct 1205 GSYFRDLWNILDFVVVVGALVAFALAN------ALGTNKGRDI-KTIKSLRVLRVLRPLK 1257
Query 561 SMKLMAVVASTVLGLVQNMRAFGGILVVVY---YVFAIIGINLFRG 603
++K + + + +V +++ IL+V ++FA+I + LF+G
Sbjct 1258 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKG 1303
Score = 34.3 bits (77), Expect = 6.0, Method: Compositional matrix adjust.
Identities = 26/120 (22%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query 143 KGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE--------PLRIRRLLRPFF 194
+G + + ++LW + VV+V +LV + ++ +L ++ LR+ R+LRP
Sbjct 1198 QGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLK 1257
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG---KQDDGQDRER 251
++ +K C+ SL + ++ ++ + + +F + + LF G D +D E+
Sbjct 1258 TIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEK 1317
>sp|P56699|CAC1E_DIPOM Probable voltage-dependent R-type calcium
channel subunit alpha-1E OS=Diplobatis ommata OX=1870830
PE=2 SV=1
Length=2223
Score = 67.0 bits (162), Expect = 5e-10, Method: Compositional matrix adjust.
Identities = 135/649 (21%), Positives = 255/649 (39%), Gaps = 145/649 (22%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E + +F + +K G++F + +N W ++ ++VVL L +L
Sbjct 138 EQTEPYFIGIFCFEAGIKIVALGFVFHKGSYLRNGWNVMDFIVVLSGLLATAATHFNL-- 195
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 196 -RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYYG 254
Query 241 GKQ-----DDG-------------QDRERL-----------------TYFQNLPESLTSL 265
DD Q+ RL T F N+ +L ++
Sbjct 255 KLHRTCYTDDAAAEELDLQFPCGTQEPTRLCPNGTVCSYWIGPNDGITQFDNILFALLTV 314
Query 266 LVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF----- 315
+T ++ Y+ + A ++FI +IGS F++NL+ ++ +F
Sbjct 315 FQCITMEGWTTIL---YNTDDALGAMWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 371
Query 316 -----RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
R +L Q + R G RA + ++ + ++ L VL++
Sbjct 372 RVENRRSFLKLRRQQQIERELNGYRAWIDKAEEVM----LLEENKNAGEKSALHVLRRAT 427
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ K+ ME +++ S E + + L R+ +K S + L G
Sbjct 428 I----KKGRMEMIQTESSED-QYTEISSVGSPLARASIK--------------STKLLEG 468
Query 431 HYYFDYLGNL--IALANLVSICVF-------LVLDADVLPAERDDFILGILNCVFIVYYL 481
YF + I++ ++V F + L+ + D L + N ++ +
Sbjct 469 SSYFRRKERMLRISIRHMVKSHAFYWIVLGLVALNTVCVAVVHYDQPLWLSNFLYYAEFT 528
Query 482 L------EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
EM LK++ G R Y N FD + + + + T+ RPE
Sbjct 529 FLGLFSSEMFLKMYGCGPRLYFHSSFNCFDCGVIIGSIFDVVWTII---------RPETS 579
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF-- 593
+S+ L R LRI K A + + V+ L+ +M++ +L +++
Sbjct 580 FGISV---------LRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVV 630
Query 594 -AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
A++G+ LF G G+ P NFD F AA++T++ ++
Sbjct 631 FALLGMQLFGG---------QFNFEEGTPP-----------TNFDTFPAAIITVFQILTG 670
Query 653 NNW-QVFLDAYRRY----SGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
+W +V + + SG WS +YF++ L + +N+FLA+ ++N
Sbjct 671 EDWNEVMYNGIKSQGGVNSGMWSSVYFIVLTLFGNYTLLNVFLAIAVDN 719
Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 61/244 (25%), Positives = 106/244 (43%), Gaps = 51/244 (21%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L ++N F + + LE +LK+ A G Y NVFD +TVV + EI
Sbjct 1460 VLKLMNIAFTITFTLECILKIIAFGFLNYFRDSWNVFD-FVTVVGSISEI---------- 1508
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+V +L + L+ L +FR R+I ++ + + VQ+ +A + +
Sbjct 1509 ------IVTECNLKFVN--LSFLKLFRAARLIKLLRQGITIRILLWTFVQSFKALPYVCL 1560
Query 588 VV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
++ ++++AIIG+ LF + G P N NNF F AL+
Sbjct 1561 LIAMLFFIYAIIGMQLFGNI-----GLDDHTPINRH-------------NNFHTFFNALM 1602
Query 645 TLWNLMVVNNWQVFL---------DAYRRYS--GPWSKIYFVLWWLVSSVIWVNLFLALI 693
L+ +WQ + + R S + YFV + + S + +NLF+A+I
Sbjct 1603 LLFRSATGESWQEIMLACLSGKECEGTREPSCGTDVAYFYFVSFIFLCSFLMLNLFVAVI 1662
Query 694 LENF 697
++NF
Sbjct 1663 MDNF 1666
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 61/293 (21%), Positives = 116/293 (40%), Gaps = 49/293 (17%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC--VFIVYYLLEMLLKVFAL 491
F+Y+ LA +++ CV L L+ + ++ + FI + E +K+ AL
Sbjct 104 FEYM----ILATIIANCVVLALEQHLPNGDKTPMAKSLEQTEPYFIGIFCFEAGIKIVAL 159
Query 492 GL---RG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
G +G YL NV D VVL L + + L R L
Sbjct 160 GFVFHKGSYLRNGWNVMD--FIVVLSGLLATAATHFNL-------------------RTL 198
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-- 605
+ V R L+++ + + +V +++ + + G +L +FAIIG+ + G +
Sbjct 199 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYYGKLHR 258
Query 606 VALPGNSSLAPANGSAPCGSFEQLE---------YW------ANNFDDFAAALVTLWNLM 650
+++ + PCG+ E YW FD+ AL+T++ +
Sbjct 259 TCYTDDAAAEELDLQFPCGTQEPTRLCPNGTVCSYWIGPNDGITQFDNILFALLTVFQCI 318
Query 651 VVNNWQVFL-DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
+ W L + W+ +YF+ ++ S +NL L ++ F + +
Sbjct 319 TMEGWTTILYNTDDALGAMWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE 371
Score = 38.5 bits (88), Expect = 0.31, Method: Compositional matrix adjust.
Identities = 50/221 (23%), Positives = 93/221 (42%), Gaps = 21/221 (10%)
Query 120 PPCGLTESVEVLCL---LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS- 175
PP G ++++ + + F + +K FG+ ++ ++ W + V +V S+ + V+
Sbjct 1453 PPPGFASVLKLMNIAFTITFTLECILKIIAFGFLNYFRDSWNVFDFVTVVGSISEIIVTE 1512
Query 176 --LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
L V L++ R R LL+ ++ L S + V LL+A+ ++ +
Sbjct 1513 CNLKFVNLSFLKLFRAARLIKLLRQGITIRILLWTFVQSFKALPYVCLLIAMLFFIYAII 1572
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI-------------P 280
GM LF DD R F +L L T + ++M+ P
Sbjct 1573 GMQLFGNIGLDDHTPINRHNNFHTFFNALMLLFRSATGESWQEIMLACLSGKECEGTREP 1632
Query 281 AYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMK 321
+ + AY +F+ F + S ++NL A+I F YL +
Sbjct 1633 SCGTDVAY-FYFVSFIFLCSFLMLNLFVAVIMDNFE-YLTR 1671
Score = 37.7 bits (86), Expect = 0.46, Method: Compositional matrix adjust.
Identities = 63/334 (19%), Positives = 134/334 (40%), Gaps = 49/334 (15%)
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
Q+ Q ++ +D + + M+ + + G+ S+ S VKE + +
Sbjct 1033 QDKTQEQTEIDVDCENTETPMDSLVTPGNAYSSS------------SSVKEDEKKSKAII 1080
Query 420 PFLQSAQFLFGHYY-FDYLGNLIALANLVSICVFLVLDADVL------PAERD---DFIL 469
P+ ++ FLF + + I +C+ LV+ A + P +D + +L
Sbjct 1081 PY--TSMFLFRKTNPIRRVCHFIVNLRYFEMCILLVIAASSVALAAEDPIHKDSARNQVL 1138
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
+ VF + EM++K+ +GL + + + F + ++ ++ L + +
Sbjct 1139 RYFDYVFTGVFTFEMVIKMIDIGL---VFHEGSYFRDVWNILDFIVVSGALVAFAFTN-- 1193
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
++G S D+ + L V R LR + ++K + + + +V +++ IL+V
Sbjct 1194 ----LIGGSSGKDIN-TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVY 1248
Query 590 Y---YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG--------SFEQLEYWANNFDD 638
++FA+I + LF+G +S + + S E ++D+
Sbjct 1249 KLFMFIFAVIAVQLFKGKFFYCTDSSKMTKQDCRGQFVLYRQRTKLSIENGNVTTFHYDN 1308
Query 639 FAAALVTLWNLMVVNNW----QVFLDAYRRYSGP 668
AL+TL+ + W Q +D GP
Sbjct 1309 VVWALLTLFTVSTGEGWPQVLQHSVDVTEADQGP 1342
>sp|Q02789|CAC1S_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Mus musculus OX=10090 GN=Cacna1s PE=1
SV=3
Length=1852
Score = 66.6 bits (161), Expect = 8e-10, Method: Compositional matrix adjust.
Identities = 70/304 (23%), Positives = 133/304 (44%), Gaps = 47/304 (15%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P+ ++ YF+YL + AL L +IC+ + +E+ + I ILN F
Sbjct 1104 KNPYQYQVWYVVTSSYFEYL--MFALIMLNTICLGM---QHYNQSEQMNHISDILNVAFT 1158
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPE 533
+ + LEM+LK+ A RGY P NVFD L+ + +++ EI T
Sbjct 1159 IIFTLEMVLKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGG 1218
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF---GGILVVVY 590
+ +FR +R++ + V + + +++ +A ++V+++
Sbjct 1219 CGNVDPDESARISSAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLF 1278
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+++A+IG+ +F G I + G Q+ NNF F A++ L+
Sbjct 1279 FIYAVIGMQMF-GKIAMVDGT----------------QINR-NNNFQTFPQAVLLLFRCA 1320
Query 651 VVNNWQVFLDA--YRRYSGPWSK---------------IYFVLWWLVSSVIWVNLFLALI 693
WQ L A Y + P S YF+ ++++ + + +NLF+A+I
Sbjct 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEHTCGTNFAYYYFISFYMLCAFLIINLFVAVI 1380
Query 694 LENF 697
++NF
Sbjct 1381 MDNF 1384
Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 76/334 (23%), Positives = 136/334 (41%), Gaps = 59/334 (18%)
Query 411 HPPRPEY----QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
PPR + Q+P ++ + F+ + L AN V++ V+L + D + +
Sbjct 26 RPPRALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPED----DNNT 81
Query 467 FILGI--LNCVFIVYYLLEMLLKVFALGL----RGYLSYPSNVFD------GLLTVVLLV 514
LG+ L F++ + +E +K+ A G YL NV D G+ TV+L
Sbjct 82 LNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQ 141
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ I + G GL + L V R LR++ + + VV +++
Sbjct 142 VNIIQTNTAPMSSKG-----AGL-----DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFK 191
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGV-----------IVALPGNSSLAPA------ 617
+ + +++ + ++AIIG+ LF+G IVA N +P
Sbjct 192 AMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSG 251
Query 618 -----NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
NGS G + + +FD+F +++T++ + + W L DA
Sbjct 252 RPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDA---IGNE 308
Query 669 WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
W IYFV L+ S +NL L ++ F + +
Sbjct 309 WPWIYFVTLILLGSFFILNLVLGVLSGEFTKERE 342
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 113/500 (23%), Positives = 190/500 (38%), Gaps = 108/500 (22%)
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---- 289
GM LF GG+ D R + F N P++L S+ +LT + VM Y+ AY
Sbjct 577 GMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVM---YNGIMAYGGPTY 632
Query 290 ------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFEVLS 342
I+FI+ V G+ L+N+ AI + S Q + R + + +
Sbjct 633 PGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSKGLPD 692
Query 343 SMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
E + + K + + K+++D + + E Y S + +
Sbjct 693 KSEEERATVTKKLEQKSKGEGIPTTAKLKID-EFESNVNEVKDPYPSADFPGD------D 745
Query 402 ELDRSVVKEHP-PRP-------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVS----- 448
E D + P PRP E P +++ F + F + L + +
Sbjct 746 EEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSF----FIFSPTNKIRVLCHRIVNATWF 801
Query 449 ---ICVFLVLDADVLPAE---RDDF----ILGILNCVFIVYYLLEMLLKVFALG------ 492
I +F++L + L AE R D IL + VF + +E++LK+ G
Sbjct 802 TNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKG 861
Query 493 --LRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
R Y N+ D L+ V L+ LE S ++V ++L
Sbjct 862 SFCRNYF----NILDLLVVAVSLISMGLESSAISV---------------------VKIL 896
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV---VYYVFAIIGINLFRGV 604
+L V R LR I K + V V + R G I++V + ++FA IG+ LF+G
Sbjct 897 RVLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIVLVTTLLQFMFACIGVQLFKGK 953
Query 605 IVALPGNSSLAPANGSA-----PCGSFEQLE----YWANN---FDDFAAALVTLWNLMVV 652
+ S + G Q+E W +N FD+ +A+++L+ +
Sbjct 954 FYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTF 1013
Query 653 NNWQVFL----DAYRRYSGP 668
W L D+ +GP
Sbjct 1014 EGWPQLLYKAIDSNEEDTGP 1033
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 56/237 (24%), Positives = 106/237 (45%), Gaps = 50/237 (21%)
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTV--VLLVLEISTLAVYRLPHP 528
+ N V + + +EML+K++ LGLR Y N FD + +L +L + + A+ L
Sbjct 466 VANRVLLTLFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMSPLG-- 523
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGI 585
+++L R LR+ K +++ V L+ ++R + +
Sbjct 524 ------------------ISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLL 565
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
L + +FA++G+ LF G FE E +NFD+F AL++
Sbjct 566 LFLFIIIFALLGMQLFGGRY-------------------DFEDTEVRRSNFDNFPQALIS 606
Query 646 LWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
++ ++ +W V + Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 607 VFQVLTGEDWNSVMYNGIMAYGGPTYPGVLVCIYFIILFVCGNYILLNVFLAIAVDN 663
Score = 37.4 bits (85), Expect = 0.63, Method: Compositional matrix adjust.
Identities = 36/168 (21%), Positives = 82/168 (49%), Gaps = 14/168 (8%)
Query 81 VCQRTLS---FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+C R ++ FT F++LF+ + ++L + +R + + + E + + VF
Sbjct 791 LCHRIVNATWFTNFILLFILL--SSAALAAEDPIRADSMRNQ----ILEYFDYVFTAVFT 844
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRP 192
++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+LRP
Sbjct 845 VEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLRVLRP 904
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ + +K ++C+ ++ + ++ L+ + +F G+ LF G
Sbjct 905 LRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
>sp|Q05152|CAC1B_RABIT Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Oryctolagus cuniculus OX=9986 GN=CACNA1B
PE=1 SV=1
Length=2339
Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 136/629 (22%), Positives = 253/629 (40%), Gaps = 133/629 (21%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
G++ + +N W ++ ++VVL L L LR R+LRP L+ +
Sbjct 153 GFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT---LRAVRVLRPLKLVSGIPSL 209
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG---------------------G 241
+ LK I ++ + +GLLL + +F + G+ + G G
Sbjct 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDPDPVGDFPCG 269
Query 242 KQ-------DDGQDRE-------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
K+ D + RE +T F N+ ++ ++ +T D++ Y+ N A
Sbjct 270 KEAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGWTDIL---YNTNDA 326
Query 288 YA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVL- 341
++FI +IGS F++NL+ ++ +F + R R+ R AF L
Sbjct 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF----------AKERERVENRRAFLKLR 376
Query 342 --SSMVGEGGAFPQAVGVKPQNLL-----QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
+ E + + + + +L +K LD+ K+A +K RS L+ AE
Sbjct 377 RQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDAVLKRAAAKKSRSD---LIQAE 433
Query 395 EFQKLFNEL-------DRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLG------NLI 441
E + L R+ +K S + + + +F + + ++
Sbjct 434 EGEGRLTGLCAPGSPFARASLKSGKTE---SSSYFRRKEKMFRFFIRRMVKAQSFYWTVL 490
Query 442 ALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS 501
+ L ++CV +V +R L VF+ +L EM LK++ LG R Y
Sbjct 491 CVVALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF 547
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPS 561
N FD +V + E+ AV PG + +++L R LRI
Sbjct 548 NCFD-FGVIVGSIFEVVWAAV----KPG-------------TSFGISVLRALRLLRIFKV 589
Query 562 MKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
K + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 590 TKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF------------- 636
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYS-GPWSKIY 673
+F+ E NFD F AA++T++ ++ +W + ++ S G +S Y
Sbjct 637 ------NFKD-ETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSRGMFSSFY 689
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWD 702
F++ L + +N+FLA+ ++N + +
Sbjct 690 FIVLTLFGNYTLLNVFLAIAVDNLANAQE 718
Score = 57.8 bits (138), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 69/288 (24%), Positives = 122/288 (42%), Gaps = 53/288 (18%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGL--- 493
LA +++ C+ L L D D P +ER L FI + E +K+ ALG
Sbjct 102 LATIIANCIVLALEQHLPDGDKTPMSER----LDDTEPYFIGIFCFEAGIKILALGFVLH 157
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+G SY N ++ + VV+L ++T + +D+ R L + V
Sbjct 158 KG--SYLRNGWNVMDFVVVLTGILATAG-----------------TDFDL-RTLRAVRVL 197
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI--VALPGN 611
R L+++ + + VV +++ + + G +L +FAIIG+ + G P +
Sbjct 198 RPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNS 257
Query 612 SSLAPANGSAPC----------GSFEQLEYWA------NNFDDFAAALVTLWNLMVVNNW 655
+ P G PC G E EYWA NFD+ A++T++ + + W
Sbjct 258 TDPDPV-GDFPCGKEAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGW 316
Query 656 QVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L +G W+ +YF+ ++ S +NL L ++ F + +
Sbjct 317 TDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 364
Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 59/252 (23%), Positives = 108/252 (43%), Gaps = 62/252 (25%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV-----LLVLEISTL 520
+ +L LN VF + +E +LK+ A G+ Y NVFD +TV+ +LV EI+
Sbjct 1505 ELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD-FVTVLGSITDILVTEIANN 1563
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+ L+ L +FR R+I ++ + + VQ+ +
Sbjct 1564 FIN-----------------------LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1600
Query 581 AFGGILVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
A + +++ ++++AIIG+ +F +AL ++S+ NNF
Sbjct 1601 ALPYVCLLIAMLFFIYAIIGMQVFGN--IALDDDTSI----------------NRHNNFR 1642
Query 638 DFAAALVTLWNLMVVNNWQVFL---------DAYRRYS---GPWSKIYFVLWWLVSSVIW 685
F AL+ L+ W + D + S ++ YFV + + S +
Sbjct 1643 TFLQALMLLFRSATGEAWHEIMLSCLSSRACDEHSNASECGSDFAYFYFVSFIFLCSFLM 1702
Query 686 VNLFLALILENF 697
+NLF+A+I++NF
Sbjct 1703 LNLFVAVIMDNF 1714
Score = 39.3 bits (90), Expect = 0.19, Method: Compositional matrix adjust.
Identities = 68/305 (22%), Positives = 124/305 (41%), Gaps = 40/305 (13%)
Query 387 GSVLLSAEEFQKLFNELDRSVVKEHPPRP--EYQSPFLQSAQFLFG---HY-----YFDY 436
G+V L ++ K E++ S V PRP Y S F S L HY YF+
Sbjct 1102 GNVDLESQAEGK--KEVETSDVMRSGPRPIVPYSSMFCLSPTNLLRRCCHYIVTMRYFEM 1159
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + L SI L + V + L ++ +F + EM++K+ LGL
Sbjct 1160 V--ILVVIALSSIA--LAAEDPVRTDSPRNNALKYMDYIFTGVFTFEMVIKMIDLGL--- 1212
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L +P F L ++ ++ L + G + + + + + L +L V R L
Sbjct 1213 LLHPGAYFRDLWNILDFIVVSGALVAFAFS--GSKGKDISTI------KSLRVLRVLRPL 1264
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
+ I + + V V+ ++N+ + ++ ++FA+I + LF+G S
Sbjct 1265 KTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1324
Query 617 ANGSAPCGSFEQLEYWAN---------NFDDFAAALVTLWNLMVVNNWQVFL----DAYR 663
+ +E+ E A ++D+ AL+TL+ + W + L DA
Sbjct 1325 RDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATY 1384
Query 664 RYSGP 668
GP
Sbjct 1385 EEQGP 1389
>sp|O00555|CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Homo sapiens OX=9606 GN=CACNA1A PE=1
SV=3
Length=2506
Score = 65.5 bits (158), Expect = 2e-09, Method: Compositional matrix adjust.
Identities = 135/667 (20%), Positives = 261/667 (39%), Gaps = 175/667 (26%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
+ E + +F + +K G+ F + +N W ++ ++VVL L L
Sbjct 134 DDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 193
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 194 ---LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMG 250
Query 241 GKQ----DDGQD--------------------------------RERLTYFQNLPESLTS 264
++G D +T F N+ ++ +
Sbjct 251 KFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLT 310
Query 265 LLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ +T D++ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 311 VFQCITMEGWTDLL---YNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF---- 363
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
+ R R+ R AF L++ ++ Q++
Sbjct 364 ------AKERERVENRRAF------------------------LKLRRQQQIER-ELNGY 392
Query 380 MEKVRSYGSVLLSAEEF----QKLFNELDRSVVKE------HPPRPEYQ--------SPF 421
ME + V+L+ +E + F+ L R+ +K+ +P E Q SPF
Sbjct 393 MEWISKAEEVILAEDETDGEQRHPFDALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPF 452
Query 422 ----LQSAQFLFGHYYFD-------YLGNLI----------ALANLVSICVFLVLDADVL 460
++SA+ ++ Y+ ++ +L L ++CV +V
Sbjct 453 ARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ-- 510
Query 461 PAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTL 520
P DF+ +F+ ++ EM +K++ LG R Y N FD ++ + E+
Sbjct 511 PEWLSDFLY-YAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFD-CGVIIGSIFEV--- 565
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
++ + PG + +++L R LRI K A + + V+ L+ +M+
Sbjct 566 -IWAVIKPG-------------TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMK 611
Query 581 ---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
+ +L + VFA++G+ LF G G+ P NFD
Sbjct 612 SIISLLFLLFLFIVVFALLGMQLFGGQFNF---------DEGTPPT-----------NFD 651
Query 638 DFAAALVTLWNLMVVNNW-QVFLDAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLAL 692
F AA++T++ ++ +W +V D + G IYF++ L + +N+FLA+
Sbjct 652 TFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAI 711
Query 693 ILENFLH 699
++N +
Sbjct 712 AVDNLAN 718
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 66/286 (23%), Positives = 119/286 (42%), Gaps = 48/286 (17%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
LA +++ C+ L L D D P +ER L FI + E +K+ ALG +
Sbjct 105 LATIIANCIVLALEQHLPDDDKTPMSER----LDDTEPYFIGIFCFEAGIKIIALGFAFH 160
Query 497 L-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
SY N ++ + VV+L ++T+ + +D+ R L + V R
Sbjct 161 KGSYLRNGWNVMDFVVVLTGILATVG-----------------TEFDL-RTLRAVRVLRP 202
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV--IVALPGNSS 613
L+++ + + VV +++ + + G +L +FAIIG+ + G +
Sbjct 203 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTD 262
Query 614 LAPANGSAPCGSFEQLE----------YWA--NN----FDDFAAALVTLWNLMVVNNWQV 657
APCG+ E YW NN FD+ A++T++ + + W
Sbjct 263 DIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTD 322
Query 658 FLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
L SG W+ +YF+ ++ S +NL L ++ F + +
Sbjct 323 LLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 368
Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 56/246 (23%), Positives = 105/246 (43%), Gaps = 46/246 (19%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L + N VF + LE +LKV A G+ Y N+FD +TV+ + +I
Sbjct 1597 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD-FVTVLGSITDIL---------- 1645
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI--- 585
+ + L+ L +FR R+I ++ + + VQ+ +A +
Sbjct 1646 --------VTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1697
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++++AIIG+ +F GN + + + F+ E+ NNF F AL+
Sbjct 1698 IAMLFFIYAIIGMQVF--------GNIGIDVEDEDSDEDEFQITEH--NNFRTFFQALML 1747
Query 646 LWNLMVVNNWQVFLDA--------------YRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
L+ W + + R ++ YFV + + S + +NLF+A
Sbjct 1748 LFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVA 1807
Query 692 LILENF 697
+I++NF
Sbjct 1808 VIMDNF 1813
>sp|P22002|CAC1C_RAT Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Rattus norvegicus OX=10116 GN=Cacna1c PE=1
SV=1
Length=2169
Score = 63.9 bits (154), Expect = 4e-09, Method: Compositional matrix adjust.
Identities = 126/655 (19%), Positives = 269/655 (41%), Gaps = 108/655 (16%)
Query 82 CQRTLSFTIFLILFLAFIETPS-SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
C R ++ TIF L L FI S SL + V++ + + +++ +F ++
Sbjct 923 CHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH----ILFYFDIVFTTIFTIEI 978
Query 141 SVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFL 195
++K +G F +N + + L+V+ VSL+ + + S + + LR+ R+LRP
Sbjct 979 ALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPL-R 1037
Query 196 LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYF 255
+ + +K ++C+ ++ + ++ ++ + +F G+ LF GK D +
Sbjct 1038 INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK-GKLYTCSDSSK---- 1092
Query 256 QNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
Q ES + + T + ++ P +N + ++ +M L T + +
Sbjct 1093 QTEAESKGNYITYKTGEVDHPIIQPRSWENSKFDFDNVLAA------MMALFTVSTFEGW 1146
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH 375
L +S+ + T + + V F + + ++ + + +
Sbjct 1147 PELLYRSIDSH-------TEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1199
Query 376 KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
+Q E Y + L + Q + L + + P+ ++Q ++ YF+
Sbjct 1200 EQGEQE----YKNCELDKNQRQCVEYALKARPLPRYIPKNQHQ----YKVWYVVNSTYFE 1251
Query 436 YLGNLIALANLVSI--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
YL ++ L N + + C+F + + ILN +F + +EM+LK
Sbjct 1252 YLMFVLILLNTICLAMQHYGQSCLFKI-------------AMNILNMLFTGLFTVEMILK 1298
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ A + Y N FD L+ VV +++I+ V+ H P M S + +R+
Sbjct 1299 LIAFKPKHYFCDAWNTFDALI-VVGSIVDIAITEVHPAEHTQCSPSM----SAEENSRI- 1352
Query 548 NMLIVFRFLRIIPSMKLMAVVAS------TVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ FR R++ +KL++ T + Q + ++V++++++A+IG+ +F
Sbjct 1353 -SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF 1411
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
+AL + + NNF F A++ L+ WQ + A
Sbjct 1412 GK--IALNDTTEIN----------------RNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1453
Query 662 YR--RYSGPWSK-----------------IYFVLWWLVSSVIWVNLFLALILENF 697
+ P S+ YF+ ++++ + + +NLF+A+I++NF
Sbjct 1454 CMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1508
Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 74/306 (24%), Positives = 132/306 (43%), Gaps = 48/306 (16%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ +++ D A + L + +F++ + +E LKV A GL
Sbjct 162 LTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGLLFHPNA 219
Query 496 YLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL N+ D ++ VV L +LE +T A + G + +D+ + L V
Sbjct 220 YLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KALRAFRV 271
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G
Sbjct 272 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ 331
Query 605 --IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
I+ +P +P NG+ ++ ++ NFD+FA A++T++ +
Sbjct 332 EGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCIT 391
Query 652 VNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPR 704
+ W L DA Y PW +YFV + S +NL L ++ F K R
Sbjct 392 MEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKAR 448
Query 705 SHLQPL 710
Q L
Sbjct 449 GDFQKL 454
Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 159/697 (23%), Positives = 280/697 (40%), Gaps = 150/697 (22%)
Query 64 HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
HR+ S Y R ++ C+R + +L++FL F+ T + A Y
Sbjct 525 HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPH 580
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW-------LLGYLVVLVVSLV 170
W T + +L L F A++ +K Y G + +L+ + G ++ ++
Sbjct 581 WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVET 638
Query 171 DWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
L + C R RLLR F + + + + + + SL +AS+ LLL + + +F
Sbjct 639 KIMSPLGISC---WRCVRLLRIFKITRYWNSLSNLVASLLNSLRSIASLLLLLFLFIIIF 695
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA- 289
++ GM LF GGK + + + R + F N P+SL ++ +LT + VM Y AY
Sbjct 696 SLLGMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM---YDGIMAYGG 751
Query 290 ---------IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEV 340
I+FI+ + + L+NL AI A E
Sbjct 752 PSFPGMLVCIYFIILFISPNYILLNLFLAIAVDNL--------------------ADAES 791
Query 341 LSSMVGEGGAFPQ----AVGVKPQNLLQVLQKVQLDSSHKQAM-MEKVRSYG----SVLL 391
L+S E + A P+ +V++K ++ S ++ + ++ + + G + +
Sbjct 792 LTSAQKEEEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKI 851
Query 392 SAEEFQKLFNELDRSVVKEHP----------------PRP---------EYQSPFLQ-SA 425
+ ++ Q NE D+S +P PRP E P + SA
Sbjct 852 NMDDLQPSENE-DKS-PHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 909
Query 426 QFLFG-----HYYFDYLGNLIALANLVSICVFLVLDADVLPAER-------DDFILGILN 473
F+F + N NL I F++L + L AE + IL +
Sbjct 910 FFIFSPNNRFRLQCHRIVNDTIFTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFD 967
Query 474 CVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VF + +E+ LK+ A G +G S+ N F+ L LLV+ +S ++ G
Sbjct 968 IVFTTIFTIEIALKMTAYGAFLHKG--SFCRNYFNIL---DLLVVSVSLISF------GI 1016
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV- 589
+ + ++ ++L +L V R LRI + L VV + + R G I++V
Sbjct 1017 QSSAI------NVVKILRVLRVLRPLRINRAKGLKHVVQCVFVAI----RTIGNIVIVTT 1066
Query 590 --YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---N 635
++FA IG+ LF+G + +S A +++ Q W N +
Sbjct 1067 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAESKGNYITYKTGEVDHPIIQPRSWENSKFD 1126
Query 636 FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
FD+ AA++ L+ + W L D++ GP
Sbjct 1127 FDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1163
Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 54/232 (23%), Positives = 108/232 (47%), Gaps = 44/232 (19%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTV--VLLVLEISTLAVYRLPHPGW 530
N + + EMLLK+++LGL+ Y N FD + +L + + T + L W
Sbjct 590 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISCW 649
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
R V LL ++ +TR N L + + +++L ++++ + +L +
Sbjct 650 R--CVRLLRIFKITRYWNSL---------------SNLVASLLNSLRSIASLLLLLFLFI 692
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+F+++G+ LF G +F++++ + FD+F +L+T++ ++
Sbjct 693 IIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQIL 733
Query 651 VVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W V D Y GP IYF++ ++ + I +NLFLA+ ++N
Sbjct 734 TGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFISPNYILLNLFLAIAVDN 785
>sp|P54282|CAC1A_RAT Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Rattus norvegicus OX=10116 GN=Cacna1a
PE=1 SV=1
Length=2212
Score = 63.2 bits (152), Expect = 8e-09, Method: Compositional matrix adjust.
Identities = 132/646 (20%), Positives = 262/646 (41%), Gaps = 132/646 (20%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
+ E + +F + +K G+ F + +N W ++ ++VVL L L
Sbjct 136 DDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 195
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 196 ---LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMG 252
Query 241 GKQ----DDGQD--------------------------------RERLTYFQNLPESLTS 264
++G D +T F N+ ++ +
Sbjct 253 KFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLT 312
Query 265 LLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ +T D++ Y+ N A ++FI +IGS F++NL+ ++ +F
Sbjct 313 VFQCITMEGWTDLL---YNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF---- 365
Query 320 MKSLQTSLFRRRLGTRAAF-------EVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQL 371
+ R R+ R AF ++ + G +A V ++ V Q+
Sbjct 366 ------AKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPF 419
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG- 430
D + ++A ++K ++ LL+ EE + ++ + V R +S L+++ F
Sbjct 420 DGALRRATLKKSKT---DLLNPEEAEDQLADI--ASVGSPFARASIKSAKLENSTFFHKK 474
Query 431 ----HYYFDYLGNLIA----LANLVSI-CVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
+Y + A + +LV++ ++L + P DF+ +F+ ++
Sbjct 475 ERRMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLY-YAEFIFLGLFM 533
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLW 541
EM +K++ LG R Y N FD ++ + E+ ++ + PG
Sbjct 534 SEMFIKMYGLGTRPYFHSSFNCFD-CGVIIGSIFEV----IWAVIKPG------------ 576
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGI 598
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++G+
Sbjct 577 -TSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 635
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW-QV 657
LF G G+ P NFD F AA++T++ ++ +W +V
Sbjct 636 QLFGG---------QFNFDEGTPPT-----------NFDTFPAAIMTVFQILTGEDWNEV 675
Query 658 FLDAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLH 699
D + G IYF++ L + +N+FLA+ ++N +
Sbjct 676 MYDEIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLAN 721
Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 66/281 (23%), Positives = 117/281 (42%), Gaps = 48/281 (17%)
Query 443 LANLVSICVFLVL-----DADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
LA +++ C+ L L D D P +ER L FI + E +K+ ALG +
Sbjct 107 LATIIANCIVLALEQHLPDDDKTPMSER----LDDTEPYFIGIFCFEAGIKIVALGFAFH 162
Query 497 L-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
SY N ++ + VV+L ++T+ + +D+ R L + V R
Sbjct 163 KGSYLRNGWNVMDFVVVLTGILATVG-----------------TEFDL-RTLRAVRVLRP 204
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV--IVALPGNSS 613
L+++ + + VV +++ + + G +L +FAIIG+ + G +
Sbjct 205 LKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTD 264
Query 614 LAPANGSAPCGSFEQLE----------YWA--NN----FDDFAAALVTLWNLMVVNNWQV 657
APCG+ E YW NN FD+ A++T++ + + W
Sbjct 265 DIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTD 324
Query 658 FLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
L SG W+ +YF+ ++ S +NL L ++ F
Sbjct 325 LLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 365
Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 57/246 (23%), Positives = 105/246 (43%), Gaps = 46/246 (19%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L + N VF + LE +LKV A G+ Y N+FD +TV+ + +I
Sbjct 1549 LRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFD-FVTVLGSITDIL---------- 1597
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI--- 585
+ + L+ L +FR R+I ++ + + VQ+ +A +
Sbjct 1598 --------VTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1649
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++++AIIG+ +F GN + + + F+ E+ NNF F AL+
Sbjct 1650 IAMLFFIYAIIGMQVF--------GNIGIDGEDEDSDEDEFQITEH--NNFRTFFQALML 1699
Query 646 LWNLMVVNNWQVFL---------DAYRRYSGP-----WSKIYFVLWWLVSSVIWVNLFLA 691
L+ W + D P ++ YFV + + S + +NLF+A
Sbjct 1700 LFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVA 1759
Query 692 LILENF 697
+I++NF
Sbjct 1760 VIMDNF 1765
>sp|P22316|CAC1S_CYPCA Dihydropyridine-sensitive L-type skeletal
muscle calcium channel subunit alpha-1 OS=Cyprinus carpio
OX=7962 PE=2 SV=1
Length=1852
Score = 62.8 bits (151), Expect = 1e-08, Method: Compositional matrix adjust.
Identities = 125/586 (21%), Positives = 247/586 (42%), Gaps = 80/586 (14%)
Query 123 GLT---ESVEVLCLLVFAADLSVKGYLFG--------WAHFQKNLWLLGYL-VVLVVSLV 170
GLT ++ V+ L F ++ +K Y FG + F + +G L ++LVVS +
Sbjct 474 GLTSFQDTANVILLACFTIEMVMKMYAFGPRAYFMSIFNRFDCFVVTIGILEIILVVSNI 533
Query 171 DWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
+ +S+ +R RLLR F L + + + + + S+ +AS+ LLL + + +F
Sbjct 534 MTPLGISV-----MRCIRLLRLFKLTRYWTSLNNLVASLLNSVKSIASLLLLLFLFIVIF 588
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSKNRA 287
+ GM +F GGK + + + F N P++L S+ +LT +M I A+ ++
Sbjct 589 ALLGMQVF-GGKFNFPDRVIQRSNFDNFPQALISVFQVLTGEEWDSIMYNGIMAHGGPQS 647
Query 288 ----YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
+I+FI+ V G+ L+N+ AI L ++ + ++ A L
Sbjct 648 PGILVSIYFIILYVCGNFVLLNVFLAIAVDN----LAEAESLTAAQKEKAEEKARRKLMR 703
Query 344 MVGEGGAFPQAVGVKPQNLLQVLQKVQ-LDSSHKQAMMEKVRSYGSVL--LSAEEFQKLF 400
+ E +A+ K L++ K + + ++ K + E + V +F
Sbjct 704 TLPEKSEEEKALMAK--RLMESRSKAEGMPTTAKLKIDEFESNVNEVKDPFPPADFPGDH 761
Query 401 NELDRSVVKEHPPRP-------EYQSPFLQSAQ-FLFG--HYYFDYLGNLIALANLVSIC 450
E++ + PRP E P +++ F+FG H + ++ +I
Sbjct 762 EEVEPEIPISPRPRPMADLQLKETVVPIAEASSFFIFGPQHKFRKLCHRIVNHTTFTNII 821
Query 451 VFLVLDADVLPAERD--------DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
+ +L + + A D + +L + VF + +E++LK+ G +L S
Sbjct 822 LLFILLSSISLAAEDPIDPRSFRNKVLAYADIVFTTVFTIEIVLKMTVYG--AFLHTGSF 879
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
+ + L+V+ +S L++ G + ++ ++L +L V R LR I
Sbjct 880 CRNSFNILDLIVVGVSLLSM------GMESSTISVV------KILRVLRVLRPLRAINRA 927
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI--VALPGNSSLAPANGS 620
K + V + ++ + + +++ ++FA IG+ LF+G + P + G+
Sbjct 928 KGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKLYYCTDPLQKTAEECQGT 987
Query 621 ----APCGSFEQLE----YWAN---NFDDFAAALVTLWNLMVVNNW 655
P S +E W N NFD+ ++ L+ + W
Sbjct 988 FLKHVP-NSLHDIEVHQRMWVNSDFNFDNVLNGMLALFTISTFEGW 1032
Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 80/356 (22%), Positives = 151/356 (42%), Gaps = 45/356 (13%)
Query 383 VRSYGSVLLSAEEFQKLFNE----LDRSVVKEHPPRPEY----QSPFLQSAQFLFGHYYF 434
V + S +++ EE ++ E L + PPR + ++PF ++ + F
Sbjct 13 VAALASFIMNEEELKRKQREKLKKLQATGGNPRPPRSLFFFTLKNPFRKTCINIVEWKPF 72
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
+ + L AN V++ VFL + + + L L +F+V + LE LK+ A GL
Sbjct 73 EIIILLTIFANCVALAVFLPMPEE--DTNNTNLTLESLEYIFLVIFTLECFLKIVAYGLL 130
Query 495 GYL-SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+ +Y N ++ +L V++ + + TL V + P G +DM + L V
Sbjct 131 FHEGAYLRNCWN-ILDFVIVFMGLFTLVVDTINTIAGVPTEKG--GGFDM-KALRAFRVL 186
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR----------- 602
R LR++ + + VV S++L + + ++ + +++AI+G+ LF+
Sbjct 187 RPLRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIYAIMGLELFKCKMHKTCYYQG 246
Query 603 -GVIVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+I GN +P NG+ + + +FD+ A++T++ +
Sbjct 247 TNIIAVREGNEKPSPCAQAGHGRRCTINGTECRAGWPGPNFGITHFDNSCFAMLTVFQCI 306
Query 651 VVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
+W L DA W IYF+ LV S +NL L + F + +
Sbjct 307 TTESWTDVLYWINDA---MGNDWPWIYFLTLILVGSFFILNLVLGALSGEFTKERE 359
Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 50/236 (21%), Positives = 108/236 (46%), Gaps = 52/236 (22%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEISTLAVYRLP 526
N + + + +EM++K++A G R Y N FD G+L ++L+V I T
Sbjct 483 NVILLACFTIEMVMKMYAFGPRAYFMSIFNRFDCFVVTIGILEIILVVSNIMT------- 535
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
P + ++ R + +L +F+ R S+ + +++L V+++ + +L
Sbjct 536 -----PLGISVM------RCIRLLRLFKLTRYWTSLNNL---VASLLNSVKSIASLLLLL 581
Query 587 VVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
+ +FA++G+ +F G +F +NFD+F AL+++
Sbjct 582 FLFIVIFALLGMQVFGGKF-------------------NFPDRVIQRSNFDNFPQALISV 622
Query 647 WNLMVVNNWQ-VFLDAYRRYSGPWS-----KIYFVLWWLVSSVIWVNLFLALILEN 696
+ ++ W + + + GP S IYF++ ++ + + +N+FLA+ ++N
Sbjct 623 FQVLTGEEWDSIMYNGIMAHGGPQSPGILVSIYFIILYVCGNFVLLNVFLAIAVDN 678
Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 66/294 (22%), Positives = 129/294 (44%), Gaps = 54/294 (18%)
Query 433 YFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
YF+YL + + N + + + +D + D LN +F V + EM++K+ A
Sbjct 1135 YFEYLMFFLIMLNTLCLGIQHCNQSDHITKLSD-----TLNLIFTVLFTGEMIVKLIAFK 1189
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG--W----RPEMVGLLSLWDMTRM 546
+GY P NVFD ++ V +V + + L G W E+ + ++ + +
Sbjct 1190 AKGYFGDPWNVFDFIIVVGSIVDVVLSEVDAALEARGGLWCLHGCAEVNPMQAIAEAENV 1249
Query 547 LNMLIVFRFLRIIPSMKLMAVVAS------TVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ FR R++ +KL+ T + Q + G ++V++++++A+IG+ +
Sbjct 1250 RVSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQM 1309
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW-QVFL 659
F VAL + + NNF F A++ L+ + W +V L
Sbjct 1310 FGK--VALVDGTEIN----------------RNNNFQTFPQAVLLLFRVATGEQWPKVIL 1351
Query 660 --------DAYRRYSGPWSK---------IYFVLWWLVSSVIWVNLFLALILEN 696
DA Y GP + YF+ ++++ + + +NLF+A+I++N
Sbjct 1352 ASMYGKLCDAKSDY-GPGEEYTCGSSIAVFYFLSFYILCAFLIINLFVAIIMDN 1404
Score = 42.0 bits (97), Expect = 0.024, Method: Compositional matrix adjust.
Identities = 36/146 (25%), Positives = 64/146 (44%), Gaps = 18/146 (12%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
R+ R+LR LL S ++ L S + VGLL+ + ++ + GM +F
Sbjct 1256 FRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKVAL 1315
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA-----------------YSKNR 286
DG + R FQ P+++ L + T P V++ + Y+
Sbjct 1316 VDGTEINRNNNFQTFPQAVLLLFRVATGEQWPKVILASMYGKLCDAKSDYGPGEEYTCGS 1375
Query 287 AYAIF-FIVFTVIGSLFLMNLLTAII 311
+ A+F F+ F ++ + ++NL AII
Sbjct 1376 SIAVFYFLSFYILCAFLIINLFVAII 1401
Score = 40.8 bits (94), Expect = 0.058, Method: Compositional matrix adjust.
Identities = 47/220 (21%), Positives = 97/220 (44%), Gaps = 28/220 (13%)
Query 31 SIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY--RRYYSNVCQRTLSF 88
I + P DL + + VV I +ASS +++ + + +C R ++
Sbjct 767 EIPISPRPRPMADLQLKETVVPI------------AEASSFFIFGPQHKFRKLCHRIVNH 814
Query 89 TIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC---GLTESVEVLCLLVFAADLSVKGY 145
T F + L FI S + D P +P + +++ VF ++ +K
Sbjct 815 TTFTNIILLFILLSSISLAAED------PIDPRSFRNKVLAYADIVFTTVFTIEIVLKMT 868
Query 146 LFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLLQNSS 200
++G F +N + + L+V+ VSL+ + S + + LR+ R+LRP + +
Sbjct 869 VYGAFLHTGSFCRNSFNILDLIVVGVSLLSMGMESSTISVVKILRVLRVLRPLRAINRAK 928
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+K ++C+ ++ + ++ L+ + +F G+ LF G
Sbjct 929 GLKHVVQCMFVAIKTIGNIVLVTMLLDFMFACIGVQLFKG 968
>sp|O46669|SCNAA_CANLF Sodium channel protein type 10 subunit
alpha OS=Canis lupus familiaris OX=9615 GN=SCN10A PE=2 SV=1
Length=1962
Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 128/613 (21%), Positives = 252/613 (41%), Gaps = 109/613 (18%)
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLV 179
L E + + +F ++ +K +G+ + N W L +L+V + +SL+ + S V
Sbjct 1191 ALLEYTDRMFTFIFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLIAKILQYSDV 1250
Query 180 CH-EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R LRP L M+ + + ++P + +V L+ I +F+ G+ F
Sbjct 1251 ASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSTMGVNFF 1310
Query 239 AG--GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFT 296
AG G+ + + YF LV L+ NN + +N + F++
Sbjct 1311 AGKFGRCINKTNE----YFS---------LVPLSIVNN---ISDCKYQNHTGSFFWVNVK 1354
Query 297 VIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGG 349
V M L + + F+G+ M + ++ R + + +E M + GG
Sbjct 1355 VNFDNVAMGYLALLQVATFKGW-MDIMYAAVDARDVNLQPKWEDNVYMYLYFVIFIIFGG 1413
Query 350 AFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVK 409
F L + V +D+ ++Q K + G + EE +K +N + + K
Sbjct 1414 FF----------TLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSK 1459
Query 410 EHPPRPEYQSPFLQSAQFLFG---HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
+ P+ P + F+F FD + ++ N+++ ++++ D AE+
Sbjct 1460 K--PQKPIPRPLNKYQGFVFDIVTKQAFDIVIMVLICLNMIT----MMVETDEQSAEKTK 1513
Query 467 FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLP 526
IL +N F+ + E ++K+FAL Y + NVFD +++VL I +L +
Sbjct 1514 -ILNKINQFFVAVFTGECVMKMFAL-RHYYFTNGWNVFD----FIVVVLSIGSLVFSVI- 1566
Query 527 HPGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ L + + T R++ + + R LR+I + K + + ++ + + G
Sbjct 1567 -------LTSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGL 1619
Query 585 ILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
+L +V ++++I G+ F P S+E NF FA +++
Sbjct 1620 LLFLVMFIYSIFGMASF--------------------PHVSWEAGIDDMFNFQTFANSML 1659
Query 645 TLWNLMVVNNWQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVI 684
L+ + W L P+ ++F + ++S +I
Sbjct 1660 CLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLI 1719
Query 685 WVNLFLALILENF 697
VN+++A+ILENF
Sbjct 1720 VVNMYIAVILENF 1732
Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 68/302 (23%), Positives = 120/302 (40%), Gaps = 79/302 (26%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VF V Y E L+K+ A G YL P + D + + + E + L
Sbjct 159 VFTVIYTFEALIKILARGFCLNEFAYLRDPWDWLDFSVITLAYIGEATAL---------- 208
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
R ++ L FR LR + ++ ++ + V L+ ++R + ++
Sbjct 209 --------------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTV 254
Query 591 Y---VFAIIGINLFRGVI--------VAL---------------------------PGNS 612
+ VFA++G+ LF+G + AL PG S
Sbjct 255 FCLSVFALVGLQLFKGNLKNKCVKNCAALNETGNYSSYGKQEWNFCHRDEDFYYNKPGTS 314
Query 613 S-LAPANGS----APCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L NGS P G + + ++ +FD FA A ++L+ LM ++W+
Sbjct 315 DPLLCGNGSDAGHCPKGYLCLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQT 374
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R SG ++FVL + S VNL LA++ ++ ++ + + E T+Q T+
Sbjct 375 LRASGKMYMVFFVLVIFLGSFYLVNLILAVV--TMAYEEQNQATIDEIEAK-EKTFQETL 431
Query 723 EL 724
E+
Sbjct 432 EM 433
Score = 42.4 bits (98), Expect = 0.019, Method: Compositional matrix adjust.
Identities = 56/234 (24%), Positives = 100/234 (43%), Gaps = 40/234 (17%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L I N VF V++ EM+ K+ A Y N+FD ++ V L+ L R
Sbjct 705 MLQIGNIVFTVFFTAEMVFKIIAFDPYYYFQKRWNIFDCIIVTVSLI----ELGAAR--- 757
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
G LS+ R +L VF+ + P++ + + +G + N+ IL
Sbjct 758 -------KGSLSVL---RTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTI---ILA 804
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
++ +VFA++G L L N N SAP E+ W + DF + + ++
Sbjct 805 IIVFVFALVGKQL-------LGENYRDNRRNISAPN---EEWPRW--HMHDFFHSFLIVF 852
Query 648 NLM----VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
++ + N W + I F+ ++ +++ +NLF AL+L +F
Sbjct 853 RILCGEWIENMWACMEVGQKSI----CLILFLTVMVLGNLVVLNLFTALLLNSF 902
>sp|Q2XVR6|SC4AB_TAKRU Sodium channel protein type 4 subunit alpha
B OS=Takifugu rubripes OX=31033 GN=scn4ab PE=3 SV=1
Length=1719
Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 126/596 (21%), Positives = 247/596 (41%), Gaps = 101/596 (17%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
VF ++ +K + +G+ + N W +++ VSLV T ++ L + LR R L
Sbjct 962 VFVMEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGYSELGAIKSLRTLRAL 1021
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG +
Sbjct 1022 RPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCLIFWLIFSIMGVNLFAGKFSYCFNETS 1081
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ + ++ T + L+ AN +V N IG L L+ + T
Sbjct 1082 QEIIDTKVVDNKTECIALIK-ANFTEVRWKNVKVNYDNV-------GIGYLSLLQVAT-- 1131
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
F+G+ + ++ R + ++ +EV M + G F L
Sbjct 1132 ----FKGW-TDIMYAAVDSRDVESQPIYEVNLYMYLYFVIFIIFGSFFT----------L 1176
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K P P ++PF
Sbjct 1177 NLFIGVIIDNFNQQ----KAKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPENPFQ 1232
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
L FD ++ N+V+ ++++ D ++++ +L +N VFI+ +
Sbjct 1233 GLVFDLVTKQIFDVFIMVLICLNMVT----MMVETDEQSDKKEE-VLYWINVVFILIFTT 1287
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E LK+ AL R Y S N+FD V+++L I L + + + P + ++ L
Sbjct 1288 ECTLKIIALR-RHYFSIGWNIFD----FVVVILSILGLLLADIIEKYFVSPTLFRVIRLA 1342
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M++ A +GL +L ++ ++F+I G++ F
Sbjct 1343 RIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLIMFIFSIFGMSNF 1393
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V E L NF+ F +++ L+ + W L
Sbjct 1394 AYV--------------------KKEALIDDMFNFETFGNSMICLFMITTSAGWDGLLSP 1433
Query 660 ------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
D P + + +F + ++S ++ VN+F+A+ILENF
Sbjct 1434 IMNTPPDCDPNVENPGTTVRGNCGSPAIGIAFFSTYIIMSFLVVVNMFIAIILENF 1489
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 61/252 (24%), Positives = 109/252 (43%), Gaps = 37/252 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF +++EM+LK FA G + Y S D L+ V LV + + Y
Sbjct 951 ILEYADKVFTYVFVMEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGY---- 1006
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
E+ + SL R L L R LR + + M VV + ++G V ++ + +
Sbjct 1007 ----SELGAIKSL----RTLRAL---RPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCL 1055
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFEQLEY----WAN---N 635
+ + +F+I+G+NLF G +S + C + + + W N N
Sbjct 1056 IFWLIFSIMGVNLFAGKFSYCFNETSQEIIDTKVVDNKTECIALIKANFTEVRWKNVKVN 1115
Query 636 FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIW 685
+D+ ++L + W + D+ S P + +YFV++ + S
Sbjct 1116 YDNVGIGYLSLLQVATFKGWTDIMYAAVDSRDVESQPIYEVNLYMYLYFVIFIIFGSFFT 1175
Query 686 VNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1176 LNLFIGVIIDNF 1187
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 50/218 (23%), Positives = 100/218 (46%), Gaps = 33/218 (15%)
Query 128 VEVLCLLVFAADLSVK-------GYLFGWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLV 179
+ V+ +L+F + ++K + GW F + +L L +L+ +++ + VS +L
Sbjct 1277 INVVFILIFTTECTLKIIALRRHYFSIGWNIFDFVVVILSILGLLLADIIEKYFVSPTL- 1335
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + +F++FGM FA
Sbjct 1336 -FRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFA 1394
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA--------------------NNPDVMI 279
K++ D + F+ S+ L ++ T+A NP +
Sbjct 1395 YVKKEALID--DMFNFETFGNSMICLFMITTSAGWDGLLSPIMNTPPDCDPNVENPGTTV 1452
Query 280 PAYSKNRAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ A I FF + ++ L ++N+ AII F
Sbjct 1453 RGNCGSPAIGIAFFSTYIIMSFLVVVNMFIAIILENFN 1490
Score = 39.7 bits (91), Expect = 0.12, Method: Compositional matrix adjust.
Identities = 33/162 (20%), Positives = 77/162 (48%), Gaps = 30/162 (19%)
Query 447 VSIC-----VFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS 501
++IC VF+ ++ + A+ ++ +L + N VF + EM+ K+ A+ Y
Sbjct 519 ITICIILNTVFMAMEHYPMSADFEE-LLSVGNLVFTGIFTGEMVFKILAMDPYFYFQVGW 577
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRII 559
N+FD ++ + LV +GL ++ ++ R ++ VF+ +
Sbjct 578 NIFDSIIVTISLV-------------------ELGLANVQGLSVLRSFRLMRVFKLAKSW 618
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 619 PTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 657
>sp|Q01815|CAC1C_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Mus musculus OX=10090 GN=Cacna1c PE=1
SV=1
Length=2139
Score = 62.0 bits (149), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 162/694 (23%), Positives = 284/694 (41%), Gaps = 143/694 (21%)
Query 64 HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
HR+ S Y R ++ C+R + +L++FL F+ T + A Y
Sbjct 495 HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPH 550
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVV---LVVSLVDWT 173
W T + +L L F A++ +K Y G A+F +V ++ +++ T
Sbjct 551 WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVET 608
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+S + LR RLLR F + + + + + + S+ +AS+ LLL + + +F++
Sbjct 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---- 289
GM LF GGK + + + R + F N P+SL ++ +LT + VM Y AY
Sbjct 669 GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM---YDGIMAYGGPSF 724
Query 290 ------IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
I+FI+ + G+ L+N+ AI A E L+S
Sbjct 725 PGMLVCIYFIILFICGNYILLNVFLAIAVDNL--------------------ADAESLTS 764
Query 344 MVGEGGAFPQ----AVGVKPQNLLQVLQKVQLDSSHKQAM-MEKVRSYG----SVLLSAE 394
E + A P+ +V++K ++ S ++ + ++ + + G + ++ +
Sbjct 765 AQKEEEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMD 824
Query 395 EFQKLFNELDRSVVKEHP----------------PRP---------EYQSPFLQ-SAQFL 428
+ Q NE D+S +P PRP E P + SA F+
Sbjct 825 DLQPSENE-DKS-PHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFI 882
Query 429 FG-----HYYFDYLGNLIALANLVSICVFLVLDADVLPAER-------DDFILGILNCVF 476
F + N NL I F++L + L AE + ILG + VF
Sbjct 883 FSPNNRFRLQCHRIVNDTIFTNL--ILFFILLSSISLAAEDPVQHTSFRNHILGNADYVF 940
Query 477 IVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ LE++LK+ A G +G S+ N F+ L LLV+ +S ++ G +
Sbjct 941 TSIFTLEIILKMTAYGAFLHKG--SFCRNYFNIL---DLLVVSVSLISF------GIQSS 989
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---Y 590
+ ++ ++L +L V R LR I K + V V + R G I++V
Sbjct 990 AI------NVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQ 1040
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDD 638
++FA IG+ LF+G + +S A +++ Q W N +FD+
Sbjct 1041 FMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDN 1100
Query 639 FAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
AA++ L+ + W L D++ GP
Sbjct 1101 VLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1134
Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 66/304 (22%), Positives = 130/304 (43%), Gaps = 71/304 (23%)
Query 427 FLFGHYYFDYLGNLIALANLVSI--------CVFLVLDADVLPAERDDFILGILNCVFIV 478
++ YF+YL ++ L N + + C+F + + ILN +F
Sbjct 1214 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKI-------------AMNILNMLFTG 1260
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ +EM+LK+ A +GY S P NVFD L V+ ++++ H P M
Sbjct 1261 LFTVEMILKLIAFKPKGYFSDPWNVFD-FLIVIGSIIDVILSETNPAEHTQCSPSM---- 1315
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS------TVLGLVQNMRAFGGILVVVYYV 592
S + +R+ + FR R++ +KL++ T + Q + ++V+++++
Sbjct 1316 SAEENSRI--SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1373
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
+A+IG+ +F +AL + + NNF F A++ L+
Sbjct 1374 YAVIGMQVFGK--IALNDTTEIN----------------RNNNFQTFPQAVLLLFRCATG 1415
Query 653 NNWQVFLDAYR--RYSGPWSK-----------------IYFVLWWLVSSVIWVNLFLALI 693
WQ + A + P S+ YF+ ++++ + + +NLF+A+I
Sbjct 1416 EAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVI 1475
Query 694 LENF 697
++NF
Sbjct 1476 MDNF 1479
Score = 57.8 bits (138), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 74/306 (24%), Positives = 132/306 (43%), Gaps = 48/306 (16%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ +++ D A + L + +F++ + +E LKV A GL
Sbjct 132 LTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGLLFHPNA 189
Query 496 YLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL N+ D ++ VV L +LE +T A + G + +D+ + L V
Sbjct 190 YLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KALRAFRV 241
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G
Sbjct 242 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ 301
Query 605 --IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
I+ +P +P NG+ ++ ++ NFD+FA A++T++ +
Sbjct 302 EGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCIT 361
Query 652 VNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPR 704
+ W L DA Y PW +YFV + S +NL L ++ F K R
Sbjct 362 MEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query 705 SHLQPL 710
Q L
Sbjct 419 GDFQKL 424
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 56/237 (24%), Positives = 110/237 (46%), Gaps = 54/237 (23%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRL 525
N + + EMLLK+++LGL+ Y N FD G+L +L+ +I S L + L
Sbjct 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVL 619
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
V LL ++ +TR N L + + +++L V+++ + +
Sbjct 620 -------RCVRLLRIFKITRYWNSL---------------SNLVASLLNSVRSIASLLLL 657
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
L + +F+++G+ LF G +F++++ + FD+F +L+T
Sbjct 658 LFLFIIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLT 698
Query 646 LWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
++ ++ +W V D Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 699 VFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
>sp|Q9JIS7|CAC1F_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1F OS=Mus musculus OX=10090 GN=Cacna1f PE=1
SV=1
Length=1985
Score = 62.0 bits (149), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 55/250 (22%), Positives = 113/250 (45%), Gaps = 42/250 (17%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
++ + ILN VF + +EM+LK+ A + Y + N FD L+ VV V++I+ V
Sbjct 1224 NYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFADAWNTFDALI-VVGSVVDIAVTEVNNG 1282
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
H G E +S+ + V R ++++ + + + T + Q + +
Sbjct 1283 GHLGESSEDTSRISI----TFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 1338
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++++A+IG+ +F +VAL + + NNF F A++
Sbjct 1339 IAMIFFIYAVIGMQMFG--LVALQDGTQIN----------------RNNNFQTFPQAVLL 1380
Query 646 LWNLMVVNNWQVFL---------DAYRRYSGPWSK---------IYFVLWWLVSSVIWVN 687
L+ WQ + D + GP + +YF+ ++++ + + +N
Sbjct 1381 LFRCATGEAWQEIMLASLPGNRCDPESDF-GPGEEFTCGSSFAIVYFISFFMLCAFLIIN 1439
Query 688 LFLALILENF 697
LF+A+I++NF
Sbjct 1440 LFVAVIMDNF 1449
Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 77/307 (25%), Positives = 128/307 (42%), Gaps = 39/307 (13%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L L AN V++ V++ D + + L + VF+V + +E +LK+ A GL
Sbjct 94 FDILILLTIFANCVALGVYIPFPED--DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query 494 ----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
Y+ N+ D ++ VV L S L PG P G +D+ + L
Sbjct 152 VLHPSAYIRNGWNLLDFIIVVVGL---FSVLLEQGPGRPGDAPHTGGKPGGFDV-KALRA 207
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
V R LR++ + + +V ++++ + + +++ V ++AIIG+ LF G +
Sbjct 208 FRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTC 267
Query 610 G--NSSLAPANGSAPCGS-----------FEQLEYWA------NNFDDFAAALVTLWNLM 650
S + +PC S E W NFD+F A++T++ +
Sbjct 268 YFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFAMLTVFQCI 327
Query 651 VVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDP 703
+ W L DA Y PW +YFV + S +NL L ++ F K
Sbjct 328 TMEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKA 384
Query 704 RSHLQPL 710
R Q L
Sbjct 385 RGDFQKL 391
Score = 53.9 bits (128), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 120/534 (22%), Positives = 219/534 (41%), Gaps = 96/534 (18%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR RLLR F + ++ + + + + S+ +AS+ LLL + + +F++ GM LF GGK
Sbjct 624 LRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKF 682
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA----------IFFI 293
+ Q + + F P++L ++ +LT + VM Y AY ++FI
Sbjct 683 NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVM---YDGIMAYGGPFFPGMLVCVYFI 739
Query 294 VFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ 353
+ + G+ L+N+ AI + + R + + ++ GG
Sbjct 740 ILFICGNYILLNVFLAIAVDNLASGDAGTAKDK--GREKSSEGNPPKENKVLVPGGENED 797
Query 354 AVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP- 412
A G + + +++ + + ++ E+ G+ + EL + VV +
Sbjct 798 AKGARSEGAAPGMEEEEEEEEEEEEEEEEEEENGAGHV----------ELLQEVVPKEKV 847
Query 413 -PRPE--------YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAE 463
P PE +P ++ L H+ F L I VF++L + L AE
Sbjct 848 VPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSL-----------ILVFIILSSVSLAAE 896
Query 464 RD-------DFILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVLL 513
+ ILG + F + +E+LLK+ G RG S+ + F+ LL ++++
Sbjct 897 DPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRG--SFCRSWFN-LLDLLVV 953
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+ + + ++ S + ++L +L V R LR I K + V V
Sbjct 954 SVSLISFGIHS--------------SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF 999
Query 574 GLVQNMRAFGGILVVV---YYVFAIIGINLFRGVIVALPGNS--SLAPANGS---APCGS 625
+ R G I++V ++FA IG+ LF+G + + +L + GS P G
Sbjct 1000 VAI---RTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKESKGSFLIYPDGD 1056
Query 626 FE----QLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
+ W N NFD+ +A++ L+ + W L DA GP
Sbjct 1057 VSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGP 1110
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 55/233 (24%), Positives = 105/233 (45%), Gaps = 46/233 (20%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
N V + + +EMLLK++ LG Y++ N FD V +LE + + V + G
Sbjct 565 NKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFD-CFVVCGGILETTLVEVGAMQPLG--- 620
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+++L R LRI + A +++ V L+ +M++ +L++++
Sbjct 621 --------------ISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLF 666
Query 593 FAII---GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
I G+ LF G +F+Q + FD F AL+T++ +
Sbjct 667 IIIFSLLGMQLFGGKF-------------------NFDQTHTKRSTFDTFPQALLTVFQI 707
Query 650 MVVNNWQVFL-DAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+ +W V + D Y GP+ +YF++ ++ + I +N+FLA+ ++N
Sbjct 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDN 760
Score = 40.4 bits (93), Expect = 0.073, Method: Compositional matrix adjust.
Identities = 46/213 (22%), Positives = 86/213 (40%), Gaps = 32/213 (15%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS--------------LSLVC 180
+F ++ +K F H+ + W +++V S+VD V+ S +
Sbjct 1237 LFTIEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDTSRIS 1296
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
R+ R++R LL ++ L S + V LL+A+ ++ + GM +F
Sbjct 1297 ITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGL 1356
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR-------------- 286
DG R FQ P+++ L T ++M+ + NR
Sbjct 1357 VALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFT 1416
Query 287 ---AYAI-FFIVFTVIGSLFLMNLLTAIIYSQF 315
++AI +FI F ++ + ++NL A+I F
Sbjct 1417 CGSSFAIVYFISFFMLCAFLIINLFVAVIMDNF 1449
>sp|O73700|CAC1D_CHICK Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Gallus gallus OX=9031 GN=CACNA1D PE=2
SV=1
Length=2190
Score = 62.0 bits (149), Expect = 2e-08, Method: Compositional matrix adjust.
Identities = 134/673 (20%), Positives = 262/673 (39%), Gaps = 156/673 (23%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L++F + +K G L + +N W L V++VV L ++V L +
Sbjct 157 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGL--FSVILEQLTK 214
Query 182 E-----------------PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
E LR R+LRP L+ ++ L I ++ + + LL+
Sbjct 215 ETEGGSHSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL 274
Query 225 IHLCLFTMFGMLLFAGG--------------KQD------DGQDRE-------------- 250
+ ++ + G+ LF G ++D G R+
Sbjct 275 FVIIIYAIIGLELFIGKMHKSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVG 334
Query 251 ---RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLF 302
+T F N ++ ++ +T DV+ Y N A I+F+ ++GS F
Sbjct 335 PNGGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAIGCEWPWIYFVSLIILGSFF 391
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
++NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 392 VLNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPEND 448
Query 363 LQVLQKVQLDS-SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP- 420
+ ++ + + + M EK +S S + + V E ++P
Sbjct 449 EEADEEGKRNRVTLADLMEEKKKSRLSCFGRSSNKHASMPTSETESVNTENVSGEGENPA 508
Query 421 -------FLQSAQFLFGHYYFDYLGNLIALANLVSIC------VFLVLDADVLPAERDDF 467
+ ++F ++ A + S+ V + L+ + +E +
Sbjct 509 CCGSLCQTISKSKFSRRWRRWNRFNRRKCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQ 568
Query 468 ------ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVL 515
I I N V + + EML+K+++LGL+ Y N FD G++ +L+ L
Sbjct 569 PDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVEL 628
Query 516 EIST---LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
EI + ++V+R R LRI + A +++ V
Sbjct 629 EIMSPLGISVFR---------------------------CVRLLRIFKVTRHWASLSNLV 661
Query 573 LGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQL 629
L+ +M+ + +L + +F+++G+ LF G +F++
Sbjct 662 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------------------NFDET 702
Query 630 EYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSV 683
+ + FD+F AL+T++ ++ +W V D Y GP S IYF++ ++ +
Sbjct 703 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNY 762
Query 684 IWVNLFLALILEN 696
I +N+FLA+ ++N
Sbjct 763 ILLNVFLAIAVDN 775
Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 69/291 (24%), Positives = 120/291 (41%), Gaps = 36/291 (12%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L AN V++ V++ D + + L + F++ + +E LK+ A GL
Sbjct 123 FDIFILLSIFANCVALAVYIPFPED--DSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 180
Query 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
Y+ N+ D ++ VV L +LE T H G +P + +
Sbjct 181 LLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKPGGFDV-------KA 233
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI- 605
L V R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G +
Sbjct 234 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMH 293
Query 606 ------------------VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
A GN NG+ G + NFD+FA A++T++
Sbjct 294 KSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGGITNFDNFAFAMLTVF 353
Query 648 NLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ + W L G W IYFV ++ S +NL L ++ F
Sbjct 354 QCITMEGWTDVLYWVNDAIGCEWPWIYFVSLIILGSFFVLNLVLGVLSGEF 404
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 127/654 (19%), Positives = 263/654 (40%), Gaps = 95/654 (15%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C R ++ IF L L FI SS++ A+ R+ + + + + +F ++
Sbjct 900 CHRLINHHIFTNLILVFIML-SSVSLAAEDPIRSHSFRN--NILGYADYVFTSMFTFEII 956
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L L+V+ VSLV + + S + + LR+ R+LRP +
Sbjct 957 LKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1016
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF GK D + Q
Sbjct 1017 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK-GKFYKCTDEAK----Q 1071
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
N PE + ++ + + M+ K R + F + S +M L T + +
Sbjct 1072 N-PEECRGIYIVYKDGDVDNPMV----KERVWQNSDFNFDNVLSA-MMALFTVSTFEGWP 1125
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
L K++ ++ G V + V F + + ++ + + + +
Sbjct 1126 ALLYKAIDSN------GENVG-PVYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQE 1178
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P+ YQ F ++ F+Y
Sbjct 1179 QGEQE----YKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW----YVVNSTGFEY 1230
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR-- 494
+ ++ + N + + + + + D I+N VF + +EM+LK+ A +
Sbjct 1231 IMFVLIMLNTLCLAMQHYGQSKLFNDAMD-----IMNMVFTGVFTVEMVLKLIAFKPKIF 1285
Query 495 --------GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
GY S N FD L+ + +V + + A P P + D R+
Sbjct 1286 VRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEAD---PKPTETVTTDESGNSEDSARI 1342
Query 547 LNMLIVFRFLRIIPSMKLMAVVAS------TVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ FR R++ +KL++ T + Q + ++ ++++++A+IG+ +
Sbjct 1343 --SITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQV 1400
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F V + NNF F A++ L+ WQ +
Sbjct 1401 FGKVAM------------------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1442
Query 660 --------DAYRRYS--------GPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
D Y+ ++ IYF+ ++++ + + +NLF+A+I++NF
Sbjct 1443 ACLPGKRCDPESDYNPGEEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNF 1496
>sp|P15381|CAC1C_RABIT Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Oryctolagus cuniculus OX=9986 GN=CACNA1C
PE=1 SV=1
Length=2171
Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 62/301 (21%), Positives = 130/301 (43%), Gaps = 65/301 (22%)
Query 427 FLFGHYYFDYLGNLIALANLVSI--------CVFLVLDADVLPAERDDFILGILNCVFIV 478
++ YF+YL ++ L N + + C+F + + ILN +F
Sbjct 1244 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKI-------------AMNILNMLFTG 1290
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLL---TVVLLVLEISTLAVYRLPHPGWRPEMV 535
+ +EM+LK+ A +GY S P NVFD L+ +++ ++L + A + P E
Sbjct 1291 LFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEEN 1350
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+S+ + V R ++++ + + + T + Q + ++V++++++A+
Sbjct 1351 SRISI----TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAV 1406
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
IG+ +F +AL + + NNF F A++ L+ W
Sbjct 1407 IGMQVFGK--IALNDTTEIN----------------RNNNFQTFPQAVLLLFRCATGEAW 1448
Query 656 QVFLDAYR--RYSGPWSK-----------------IYFVLWWLVSSVIWVNLFLALILEN 696
Q + A + P S+ YF+ ++++ + + +NLF+A+I++N
Sbjct 1449 QDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDN 1508
Query 697 F 697
F
Sbjct 1509 F 1509
Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 73/306 (24%), Positives = 131/306 (43%), Gaps = 48/306 (16%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ +++ D A + L + +F++ + +E LKV A GL
Sbjct 162 LTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGLLFHPNA 219
Query 496 YLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL N+ D ++ VV L +LE +T A + G + +D+ + L V
Sbjct 220 YLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KALRAFRV 271
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G
Sbjct 272 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ 331
Query 605 --IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+ +P +P NG+ ++ ++ NFD+FA A++T++ +
Sbjct 332 EGVADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCIT 391
Query 652 VNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPR 704
+ W L DA Y PW +YFV + S +NL L ++ F K R
Sbjct 392 MEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKAR 448
Query 705 SHLQPL 710
Q L
Sbjct 449 GDFQKL 454
Score = 53.5 bits (127), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 153/676 (23%), Positives = 268/676 (40%), Gaps = 107/676 (16%)
Query 64 HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
HR+ S Y R ++ C+R + +L++FL F+ T + A Y
Sbjct 525 HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPH 580
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVV---LVVSLVDWT 173
W T + +L L F A++ +K Y G A+F +V ++ +++ T
Sbjct 581 WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVET 638
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+S + LR RLLR F + + + + + + S+ +AS+ LLL + + +F++
Sbjct 639 KVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 698
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---- 289
GM LF GGK + + + R + F N P+SL ++ +LT + VM Y AY
Sbjct 699 GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM---YDGIMAYGGPSF 754
Query 290 ------IFFIVFTVIGSLFLM---------NLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
I+FI+ + G+ L+ NL A + + + + R
Sbjct 755 PGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASP 814
Query 335 RAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLDSSHKQA-----MMEK 382
EV+ E + A G P + +Q + S ++
Sbjct 815 EKKQEVVGKPALEEAKEEKIELKSITADGESPPTTKINMDDLQPNESEDKSPYPNPETTG 874
Query 383 VRSYGSVLLSAEEFQKLFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLI 441
+ + +EL +KE P PE + F+ S F + + I
Sbjct 875 EEDEEEPEMPVGPRPRPLSELH---LKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTI 931
Query 442 ALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFALGL- 493
NL I F++L + L AE + IL + VF + +E+ LK+ A G
Sbjct 932 -FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAF 988
Query 494 --RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+G S+ N F+ L LLV+ +S ++ G + + ++ ++L +L
Sbjct 989 LHKG--SFCRNYFNIL---DLLVVSVSLISF------GIQSSAI------NVVKILRVLR 1031
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIGINLFRGVIVAL 608
V R LR I K + V V + R G I++V ++FA IG+ LF+G +
Sbjct 1032 VLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC 1088
Query 609 PGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVNNWQ 656
+S A +++ Q W N +FD+ AA++ L+ + W
Sbjct 1089 SDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWP 1148
Query 657 VFL----DAYRRYSGP 668
L D++ GP
Sbjct 1149 ELLYRSIDSHTEDKGP 1164
Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 55/237 (23%), Positives = 110/237 (46%), Gaps = 54/237 (23%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRL 525
N + + EMLLK+++LGL+ Y N FD G+L +L+ ++ S L + L
Sbjct 590 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKVMSPLGISVL 649
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
V LL ++ +TR N L + + +++L V+++ + +
Sbjct 650 -------RCVRLLRIFKITRYWNSL---------------SNLVASLLNSVRSIASLLLL 687
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
L + +F+++G+ LF G +F++++ + FD+F +L+T
Sbjct 688 LFLFIIIFSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLT 728
Query 646 LWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
++ ++ +W V D Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 729 VFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 785
>sp|O88420|SCN8A_RAT Sodium channel protein type 8 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn8a PE=1 SV=1
Length=1978
Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 128/601 (21%), Positives = 250/601 (42%), Gaps = 111/601 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ F N W L +L+V V VSL+ + S L + LR R L
Sbjct 1240 IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL 1299
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1300 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1349
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ Y N + + ++ + + ++ S + I F +G+ +L L A
Sbjct 1350 KYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVGAGYLALLQVAT 1409
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQN 361
F+G+ M + ++ R+ + +E V+ + G +GV N
Sbjct 1410 ----FKGW-MDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDN 1464
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQ 418
Q +K + G + EE +K +N + + S + P PRP +
Sbjct 1465 FNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1508
Query 419 SPFLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+Q F F FD + ++ N+V+ ++++ D + ++ IL +N VF+
Sbjct 1509 ---IQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWINLVFV 1560
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVG 536
+++ E +LK+FAL Y + N+FD V+++L I + + + + P +
Sbjct 1561 IFFTCECVLKMFAL-RHYYFTIGWNIFD----FVVVILSIVGMFLADIIEKYFVSPTLFR 1615
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
++ L + R+L ++ + +R + +M++ A +GL +L +V ++F+I
Sbjct 1616 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIFSIF 1666
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G++ F V G + NF+ F +++ L+ + W
Sbjct 1667 GMSNFAYV---------------KHEAGIDDMF-----NFETFGNSMICLFQITTSAGWD 1706
Query 657 VFL--------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILEN 696
L D P S +FV + ++S +I VN+++A+ILEN
Sbjct 1707 GLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILEN 1766
Query 697 F 697
F
Sbjct 1767 F 1767
Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 62/253 (25%), Positives = 104/253 (41%), Gaps = 39/253 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEMLLK A G + + D L+ V LV I+ Y
Sbjct 1229 ILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---- 1284
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
S + L L R LR + + M VV + ++G + ++ + +
Sbjct 1285 -----------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCL 1333
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPC-----GSFEQLEYWAN--- 634
+ + +F+I+G+NLF G +S + N C G+ ++ W N
Sbjct 1334 IFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIR-WKNVKI 1392
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL---------DAYRRYSGP-WSKIYFVLWWLVSSVI 684
NFD+ A + L + W + D Y G + IYFV++ + S
Sbjct 1393 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFF 1452
Query 685 WVNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1453 TLNLFIGVIIDNF 1465
Score = 44.7 bits (104), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 61/261 (23%), Positives = 104/261 (40%), Gaps = 78/261 (30%)
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLF-- 601
++ L FR LR + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF
Sbjct 216 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 275
Query 602 --RGVIVALP---------------------------------------GNSSLAPANGS 620
R V P GNSS A G
Sbjct 276 NLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDA---GQ 332
Query 621 APCGSFEQLE------YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF 674
P G F+ ++ Y +FD F+ A + L+ LM + W+ R +G I+F
Sbjct 333 CPEG-FQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFF 391
Query 675 VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR------- 727
VL V S VNL LA++ ++ ++ L+ A EA ++ +E L +
Sbjct 392 VLVIFVGSFYLVNLILAVVA--MAYEEQNQATLEE-AEQKEAEFKAMLEQLKKQQEEAQA 448
Query 728 ------------DILEEPGED 736
D +EE GED
Sbjct 449 AAMATSAGTVSEDAIEEEGED 469
Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 41/171 (24%), Positives = 78/171 (46%), Gaps = 28/171 (16%)
Query 439 NLIALANLV--SICVFLVLDADVLPAERD------DFILGILNCVFIVYYLLEMLLKVFA 490
NLI + V +I + +VL+ + E + +L + N VF + EM LK+ A
Sbjct 745 NLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA 804
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
+ Y N+FDG + V L ++E+S V L + R +L
Sbjct 805 MDPYYYFQEGWNIFDGFI-VSLSLMELSLADVEGL----------------SVLRSFRLL 847
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 848 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 895
>sp|Q2XVR5|SC4AA_TETNG Sodium channel protein type 4 subunit alpha
A OS=Tetraodon nigroviridis OX=99883 GN=scn4aa PE=3 SV=2
Length=1863
Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 118/600 (20%), Positives = 245/600 (41%), Gaps = 107/600 (18%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRL 189
+F ++ +K +G+ + N W ++ +SL+ + +L L + LR R
Sbjct 1093 FIFVLEMVLKWVAYGFKTYFTNAWCWLDFFIVDISLISLSANLMGLSDLGPIKSLRTLRA 1152
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1153 LRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFWLIFSIMGVNLFAG--------- 1203
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV-FTVIGSLFLMNLLT 308
++ + + L + N D M + A + V + +G +L L
Sbjct 1204 ---KFYHCINTTTQELFPISVVNNKSDCMAVQEATQEARWVNVKVNYDNVGKGYLSLLQI 1260
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQN 361
A F+G+ + ++ R + + ++E+ M + G F
Sbjct 1261 AT----FKGW-TAIMYAAVDSREVEEQPSYEINLYMYIYFVIFIIFGAFF---------- 1305
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP-EYQSP 420
L + V +D+ ++Q R G + E QK + E + + + P +P +
Sbjct 1306 TLNLFIGVIIDNFNQQK-----RKLGDKDIFMTEEQKKYYEAMKKLGSKKPQKPIPRPTN 1360
Query 421 FLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+Q F F +FD ++ N+V+ ++++ D E++DF+ + N FIV
Sbjct 1361 LIQGMVFDFISQQFFDIFIMVLICLNMVT----MMVETDDQSPEKEDFLFKV-NVAFIVV 1415
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+ AL + + + N+FD V+++L I+ + L + P + ++
Sbjct 1416 FTGECMLKLIAL-RQYFFTNGWNIFD----FVVVILSIAGTMLSDLIEKYFVSPTLFRVI 1470
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ R +R + +M++ A +GL +L ++ ++F+I G+
Sbjct 1471 RLARIGRILRLIKGARGIRTLLFALMMSLPALFNIGL---------LLFLIMFIFSIFGM 1521
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V G + NF+ F ++++ L+ + W
Sbjct 1522 SNFAYV---------------KKEAGIDDMF-----NFETFGSSIICLFQITTSGGWDQI 1561
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D P + + +F + ++S ++ VN+++A+ILENF
Sbjct 1562 LLPILNKEPPDCDPTLENPGTDVKGNCGNPMVGMMFFCSYIIISFLVVVNMYIAIILENF 1621
Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 55/251 (22%), Positives = 111/251 (44%), Gaps = 36/251 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEM+LK A G + Y + D +++IS +++
Sbjct 1083 ILEFADKVFTFIFVLEMVLKWVAYGFKTYFTNAWCWLD------FFIVDISLISL----- 1131
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
++GL L + + L L R LR + + M VV + ++G + ++ + +
Sbjct 1132 ---SANLMGLSDLGPI-KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCL 1187
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFE---QLEYWAN---NF 636
+ + +F+I+G+NLF G ++ ++ N + C + + Q W N N+
Sbjct 1188 IFWLIFSIMGVNLFAGKFYHCINTTTQELFPISVVNNKSDCMAVQEATQEARWVNVKVNY 1247
Query 637 DDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWV 686
D+ ++L + W + D+ P + IYFV++ + + +
Sbjct 1248 DNVGKGYLSLLQIATFKGWTAIMYAAVDSREVEEQPSYEINLYMYIYFVIFIIFGAFFTL 1307
Query 687 NLFLALILENF 697
NLF+ +I++NF
Sbjct 1308 NLFIGVIIDNF 1318
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 44/195 (23%), Positives = 86/195 (44%), Gaps = 31/195 (16%)
Query 151 HFQKNLWLLGYLVVLVVSLVDWTVS-------LSLVCHEPLRIRRLLRPFFLLQNSSMMK 203
+F N W + VV+++S+ +S +S +R+ R+ R L++ + ++
Sbjct 1430 YFFTNGWNIFDFVVVILSIAGTMLSDLIEKYFVSPTLFRVIRLARIGRILRLIKGARGIR 1489
Query 204 KTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLT 263
L + SLP + ++GLLL + + +F++FGM FA K++ G D + F+ S+
Sbjct 1490 TLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEAGID--DMFNFETFGSSII 1547
Query 264 SLLVLLTTANNPDVMIPAYSKNRAYA----------------------IFFIVFTVIGSL 301
L + T+ +++P +K +FF + +I L
Sbjct 1548 CLFQITTSGGWDQILLPILNKEPPDCDPTLENPGTDVKGNCGNPMVGMMFFCSYIIISFL 1607
Query 302 FLMNLLTAIIYSQFR 316
++N+ AII F
Sbjct 1608 VVVNMYIAIILENFN 1622
Score = 35.4 bits (80), Expect = 2.7, Method: Compositional matrix adjust.
Identities = 28/92 (30%), Positives = 44/92 (48%), Gaps = 10/92 (11%)
Query 608 LPGNSSLAPANGSAPCGSFEQLE------YWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
L GNSS A G P G +E ++ Y +FD F A + L+ LM + W+
Sbjct 329 LCGNSSDA---GRCPEG-YECMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDCWENLFQQ 384
Query 662 YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G ++FV+ + S +NL LA++
Sbjct 385 TLRAAGKTYMLFFVVVIFLGSFYLINLILAVV 416
>sp|Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4
Length=2221
Score = 61.2 bits (147), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 130/650 (20%), Positives = 258/650 (40%), Gaps = 133/650 (20%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L L++F + +K G LF + +N W L +++VV L + +
Sbjct 160 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 219
Query 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ LR R+LRP L+ ++ L I ++ + + LL+ +
Sbjct 220 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 279
Query 228 CLFTMFGMLLFAGG---------------KQDD--------GQDRE-------------- 250
++ + G+ LF G +DD G R+
Sbjct 280 IIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGP 339
Query 251 --RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFL 303
+T F N ++ ++ +T DV+ Y N A I+F+ +IGS F+
Sbjct 340 KHGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAVGRDWPWIYFVTLIIIGSFFV 396
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 397 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 453
Query 364 QVLQKVQ-LDSSHKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
+ + + + + S + E V + G + +L + + +S + R +
Sbjct 454 EGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 511
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+ + F +L + N ++I + L +D N +
Sbjct 512 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQD-----TANKALLAL 566
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
+ EMLLK+++LGL+ Y N FD G+L +L+ +I S L + L
Sbjct 567 FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL------- 619
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
V LL ++ +TR N L + + +++L V+++ + +L + +
Sbjct 620 RCVRLLRIFKITRYWNSL---------------SNLVASLLNSVRSIASLLLLLFLFIII 664
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
F+++G+ LF G +F++++ + FD+F +L+T++ ++
Sbjct 665 FSLLGMQLFGGKF-------------------NFDEMQTRRSTFDNFPQSLLTVFQILTG 705
Query 653 NNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W V D Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 706 EDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 755
Score = 59.3 bits (142), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 74/306 (24%), Positives = 131/306 (43%), Gaps = 48/306 (16%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ +++ D A + L + +F++ + +E LKV A GL
Sbjct 132 LTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGLLFHPNA 189
Query 496 YLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL N+ D ++ VV L +LE +T A + G + +D+ + L V
Sbjct 190 YLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KALRAFRV 241
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G
Sbjct 242 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQ 301
Query 605 --IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
I +P +P NG+ ++ ++ NFD+FA A++T++ +
Sbjct 302 EGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCIT 361
Query 652 VNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPR 704
+ W L DA R W IYFV ++ S +NL L ++ F K R
Sbjct 362 MEGWTDVLYWVNDAVGR---DWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKAR 418
Query 705 SHLQPL 710
Q L
Sbjct 419 GDFQKL 424
Score = 54.7 bits (130), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 71/368 (19%), Positives = 144/368 (39%), Gaps = 89/368 (24%)
Query 384 RSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIAL 443
+ Y + L + Q + L ++ + P+ ++Q ++ YF+YL ++ L
Sbjct 1195 QEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLIL 1250
Query 444 ANLVSI--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
N + + C+F + + ILN +F + +EM+LK+ A +G
Sbjct 1251 LNTICLAMQHYGQSCLFKI-------------AMNILNMLFTGLFTVEMILKLIAFKPKG 1297
Query 496 YLSYPSNVFDGL---------------------------LTVVLLVLEISTLAVYRLPHP 528
Y S P NVFD L L VV +++I+ V H
Sbjct 1298 YFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHT 1357
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
P M + + V R ++++ + + + T + Q + ++V+
Sbjct 1358 QCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVM 1417
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+++++A+IG+ +F +AL + + NNF F A++ L+
Sbjct 1418 LFFIYAVIGMQVFGK--IALNDTTEIN----------------RNNNFQTFPQAVLLLFR 1459
Query 649 LMVVNNWQVFLDAYR--RYSGPWSK-----------------IYFVLWWLVSSVIWVNLF 689
WQ + A + P S+ YF+ ++++ + + +NLF
Sbjct 1460 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1519
Query 690 LALILENF 697
+A+I++NF
Sbjct 1520 VAVIMDNF 1527
Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 57/223 (26%), Positives = 97/223 (43%), Gaps = 42/223 (19%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
ILG + VF + LE++LK+ A G +G S+ N F+ L LLV+ +S ++
Sbjct 952 ILGNADYVFTSIFTLEIILKMTAYGAFLHKG--SFCRNYFNIL---DLLVVSVSLISF-- 1004
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
G + + ++ ++L +L V R LR I K + V V + R G
Sbjct 1005 ----GIQSSAI------NVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGN 1051
Query 585 ILVVV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYW 632
I++V ++FA IG+ LF+G + +S A +++ Q W
Sbjct 1052 IVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSW 1111
Query 633 AN---NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
N +FD+ AA++ L+ + W L D++ GP
Sbjct 1112 ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1154
Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 71/267 (27%), Positives = 123/267 (46%), Gaps = 30/267 (11%)
Query 64 HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
HR+ S Y R ++ C+R + +L++FL F+ T + A Y
Sbjct 495 HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPN 550
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVV---LVVSLVDWT 173
W T + +L L F A++ +K Y G A+F VV ++ +++ T
Sbjct 551 WLTEVQDTANKALLAL--FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVET 608
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+S + LR RLLR F + + + + + + S+ +AS+ LLL + + +F++
Sbjct 609 KIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLL 668
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---- 289
GM LF GGK + + + R + F N P+SL ++ +LT + VM Y AY
Sbjct 669 GMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM---YDGIMAYGGPSF 724
Query 290 ------IFFIVFTVIGSLFLMNLLTAI 310
I+FI+ + G+ L+N+ AI
Sbjct 725 PGMLVCIYFIILFICGNYILLNVFLAI 751
Score = 35.4 bits (80), Expect = 2.4, Method: Compositional matrix adjust.
Identities = 22/102 (22%), Positives = 52/102 (51%), Gaps = 1/102 (1%)
Query 140 LSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLRPFFLLQN 198
++ G F +N + + L+V+ VSL+ + + S + + LR+ R+LRP +
Sbjct 972 MTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINR 1031
Query 199 SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ +K ++C+ ++ + ++ ++ + +F G+ LF G
Sbjct 1032 AKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG 1073
>sp|P91645|CAC1A_DROME Voltage-dependent calcium channel type
A subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=cac
PE=1 SV=3
Length=1851
Score = 61.2 bits (147), Expect = 3e-08, Method: Compositional matrix adjust.
Identities = 124/557 (22%), Positives = 231/557 (41%), Gaps = 91/557 (16%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR RLLR F + + S ++ + + S+ + S+ LL + + +F + GM LF G
Sbjct 535 LRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFN 594
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY------SKNRAYAIFFIVFTV 297
G E T F P +L ++ +LT + +VM K Y+I+FIV +
Sbjct 595 LPGGTPE--TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVL 652
Query 298 IGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGV 357
G+ L+N+ AI L + + + + L
Sbjct 653 FGNYTLLNVFLAIAVDN----LANAQELTAAEEEQVEEDKEKQL---------------- 692
Query 358 KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP-- 415
Q L + ++ +Q D H + G+V S + +K E P+P
Sbjct 693 --QELEKEMEALQADGVHVE------NGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPML 744
Query 416 EYQSPFL--------QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDF 467
Y S F+ + A ++ YFD+ ++ + ++ SI L + V R +
Sbjct 745 PYSSMFILSPTNPIRRGAHWVVNLPYFDFF--IMVVISMSSIA--LAAEDPVRENSRRNK 800
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + F + +EMLLK+ LG+ + +P + ++ V+ I +
Sbjct 801 ILNYFDYAFTGVFTIEMLLKIVDLGV---ILHPGSYLREFWNIMDAVVVICAAVSFGF-- 855
Query 528 PGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
+M G + +++ + L +L V R L+ I + + V V+ ++N+ +
Sbjct 856 -----DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIV 910
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC-GSF-----------EQLEYW- 632
++ ++F++IG+ LF G S + SA C GS+ ++L W
Sbjct 911 YILFQFIFSVIGVQLFNGKFFYCTDESK----HTSAECQGSYFKYEEDELLPKQELRVWK 966
Query 633 --ANNFDDFAAALVTLWNLMVVNNW----QVFLDAYRRYSGPWSK------IYFVLWWLV 680
A ++D+ AAA++TL+ + W Q + A GP I+++++++V
Sbjct 967 PRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIV 1026
Query 681 SSVIWVNLFLALILENF 697
+VN+F+ALI+ F
Sbjct 1027 FPFFFVNIFVALIIITF 1043
Score = 47.8 bits (112), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 53/247 (21%), Positives = 103/247 (42%), Gaps = 51/247 (21%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L +N F + +E +LK+ G++ + P N+FD L+TV+ +++ + H
Sbjct 1127 LKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFD-LITVLGSIVDALWM---EFGHD 1182
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
VG L L+ R++ +L +RI+ + VQ+ +A + ++
Sbjct 1183 DSNSINVGFLRLFRAARLIKLLRQGYTIRIL------------LWTFVQSFKALPYVCLL 1230
Query 589 V---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++AIIG+ +F G+ G+ E NNF F ++
Sbjct 1231 IAMLFFIYAIIGMQVF-----------------GNIKLGTVENSITRHNNFQSFIQGVML 1273
Query 646 LWNLMVVNNWQVFL----------DAYRRYSGPW-----SKIYFVLWWLVSSVIWVNLFL 690
L+ W + D + G + + YFV + S + +NLF+
Sbjct 1274 LFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFV 1333
Query 691 ALILENF 697
A+I++NF
Sbjct 1334 AVIMDNF 1340
Score = 45.4 bits (106), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 70/318 (22%), Positives = 126/318 (40%), Gaps = 63/318 (20%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCV 475
+P + +F+ F+Y L +AN CV L L+ + ++ L
Sbjct 24 DNPIRKYTRFIIEWPPFEYAVLLTIIAN----CVVLALEEHLPGGDKTVLAQKLEKTEAY 79
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F+ + +E LK+ ALGL YL N+ D + V + + +P
Sbjct 80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQ----------YPQIG 129
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
PE+ D+ R L + V R L+++ + + VV +++ + + G +++
Sbjct 130 PEV-------DL-RTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIV 181
Query 592 VFAIIGINLFRGVI------------------VALPGNSS--LAPANGSAPCGSFEQ--L 629
+FAIIG+ + G + P N+ L A GS C + L
Sbjct 182 IFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCL 241
Query 630 EYWA------NNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWL 679
E W +FD+ A++T++ + + W L DA ++ IYFV +
Sbjct 242 EKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDA---LGSAFNWIYFVPLIV 298
Query 680 VSSVIWVNLFLALILENF 697
+ S +NL L ++ F
Sbjct 299 IGSFFMLNLVLGVLSGEF 316
Score = 40.0 bits (92), Expect = 0.11, Method: Compositional matrix adjust.
Identities = 56/230 (24%), Positives = 97/230 (42%), Gaps = 47/230 (20%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F+ ++ EM +K++ALG R Y N FD +V+ S V W
Sbjct 479 IFLGLFMSEMFIKMYALGPRIYFESSFNRFD------CVVISGSIFEVI------WSEVK 526
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYY 591
G L++L R LRI K + + + V+ L+ +MR + +L +
Sbjct 527 GGSFG-------LSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFIL 579
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+FA++G+ LF G LPG + NF+ F AL+T++ ++
Sbjct 580 IFALLGMQLFGGQF-NLPGGTP-------------------ETNFNTFPIALLTVFQILT 619
Query 652 VNNW-----QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
+W Q + G IYF++ L + +N+FLA+ ++N
Sbjct 620 GEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDN 669
Score = 38.5 bits (88), Expect = 0.32, Method: Compositional matrix adjust.
Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E E L +F + S+K G + + +N+W ++ + VV+ + + V
Sbjct 74 EKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVD 133
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR R+LRP L+ ++ LK I ++ + +GLL+ + +F + G+ ++G
Sbjct 134 LRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSG 193
Query 241 G 241
Sbjct 194 A 194
Score = 37.0 bits (84), Expect = 0.78, Method: Compositional matrix adjust.
Identities = 43/228 (19%), Positives = 91/228 (40%), Gaps = 47/228 (21%)
Query 144 GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------LVCHEPLRIRRLLRPFFLL 196
G + + + W + VV++ + V + +S L + LR+ R+LRP +
Sbjct 825 GVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTI 884
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG--------------- 241
+ +K C+ SL + ++ ++ + +F++ G+ LF G
Sbjct 885 KRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAEC 944
Query 242 --------------KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSK 284
KQ+ + R ++ N+ ++ +L + T P V+ + A +
Sbjct 945 QGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYE 1004
Query 285 NRA--------YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQ 324
+R +IF+IV+ ++ F +N+ A+I F+ LQ
Sbjct 1005 DRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQ 1052
>sp|P02719|SCNA_ELEEL Sodium channel protein OS=Electrophorus
electricus OX=8005 PE=1 SV=1
Length=1820
Score = 60.8 bits (146), Expect = 4e-08, Method: Compositional matrix adjust.
Identities = 119/600 (20%), Positives = 246/600 (41%), Gaps = 110/600 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
VF ++ +K +G+ + + W V++ S++ T SL L + LR R L
Sbjct 1044 VFIVEMLLKWVAYGFKRYFTDAWCWLDFVIVGASIMGITSSLLGYEELGAIKNLRTIRAL 1103
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L MK ++ + ++P + +V L+ + +F++ G+ LFAG
Sbjct 1104 RPLRALSRFEGMKVVVRALLGAIPSIMNVLLVCLMFWLIFSIMGVNLFAG---------- 1153
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+++ + + +L + N D M Y+ + + + G M L+ +
Sbjct 1154 --KFYRCINTTTDEILPVEEVNNRSDCMALMYTNEVRWVNLKVNYDNAG----MGYLSLL 1207
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
S F+G+ M + ++ R + + +E+ M + G F L
Sbjct 1208 QVSTFKGW-MDIMYAAVDSREVEDQPIYEINVYMYLYFVIFIVFGAFFT----------L 1256
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP---PRPEYQSP 420
+ V +D+ ++Q K + G L EE +K +N + + K+ PRP S
Sbjct 1257 NLFIGVIIDNFNRQ----KQKLGGEDLFMTEEQKKYYNAMKKLGSKKAAKCIPRP---SN 1309
Query 421 FLQSAQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+Q + + + D + N+V++ +V D ++D IL +N +F++
Sbjct 1310 VVQGVVYDIVTQPFTDIFIMALICINMVAM---MVESEDQSQVKKD--ILSQINVIFVII 1364
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV-LEISTLAVYRLPHPGWRPEMVGLL 538
+ +E LLK+ AL + + + NVFD + V+ ++ L +S + P
Sbjct 1365 FTVECLLKLLALR-QYFFTVGWNVFDFAVVVISIIGLLLSDIIEKYFVSPT--------- 1414
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ R++ + + R LR+I + K + + ++ + + G +L ++ ++F+I G+
Sbjct 1415 ----LFRVIRLARIARVLRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGM 1470
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V G + + NF+ F +++ L+ + W
Sbjct 1471 SNFAYV----------------KKQGGVDDI----FNFETFGNSMICLFEITTSAGWDGL 1510
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D P + + +F + ++S ++ VN+++A+ILENF
Sbjct 1511 LLPTLNTGPPDCDPDVENPGTDVRGNCGNPGKGITFFCSYIILSFLVVVNMYIAIILENF 1570
Score = 47.8 bits (112), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 81/336 (24%), Positives = 144/336 (43%), Gaps = 53/336 (16%)
Query 130 VLCLLVFAADLSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLVCHEPLRI 186
V CLL L+++ Y F GW F + ++ + +L+ +++ + VS +L +R+
Sbjct 1367 VECLLKL---LALRQYFFTVGWNVFDFAVVVISIIGLLLSDIIEKYFVSPTL--FRVIRL 1421
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+ R L++ + ++ L + SLP + ++GLLL + + +F++FGM FA K+ G
Sbjct 1422 ARIARVLRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKQGG 1481
Query 247 QDRERLTYFQNLPESLTSLLVLLTTAN----------------NPDVMIPAYS-----KN 285
D + F+ S+ L + T+A +PDV P N
Sbjct 1482 VD--DIFNFETFGNSMICLFEITTSAGWDGLLLPTLNTGPPDCDPDVENPGTDVRGNCGN 1539
Query 286 RAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS---LQTSLFRRRLGTRAAFEVL 341
I FF + ++ L ++N+ AII F +S L F T F+V
Sbjct 1540 PGKGITFFCSYIILSFLVVVNMYIAIILENFGVAQEESSDLLCEDDFVMFDETWHKFDVH 1599
Query 342 SSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA------MMEKVRSYGSVLLS-AE 394
+ + P+ V N LQ ++ + HK A +ME SY VLL+ +
Sbjct 1600 GTQFLDYNDLPRFV-----NALQEPMRIPNPNRHKLAKMDMYVVMEDKISYLDVLLAVTQ 1654
Query 395 EFQKLFNELD------RSVVKEHPPRPEYQSPFLQS 424
E E++ ++ K+ P P + P + +
Sbjct 1655 EVLGDTTEMEAMRLSIQAKFKKDNPSPTFFEPVVTT 1690
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 61/283 (22%), Positives = 115/283 (41%), Gaps = 35/283 (12%)
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
DY I L+S V D + IL + VF +++EMLLK A G +
Sbjct 1000 DYFETFIIFMILLSSGVLAFEDIYIWRRRVIKVILEYADKVFTYVFIVEMLLKWVAYGFK 1059
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y + D ++ ++ S+L Y E +G + + L + R
Sbjct 1060 RYFTDAWCWLDFVIVGASIMGITSSLLGY---------EELGAI------KNLRTIRALR 1104
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS- 613
LR + + M VV +LG + ++ + ++ + +F+I+G+NLF G ++
Sbjct 1105 PLRALSRFEGMKVVVRALLGAIPSIMNVLLVCLMFWLIFSIMGVNLFAGKFYRCINTTTD 1164
Query 614 ----LAPANGSAPCGS--FEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL----D 660
+ N + C + + W N N+D+ ++L + W + D
Sbjct 1165 EILPVEEVNNRSDCMALMYTNEVRWVNLKVNYDNAGMGYLSLLQVSTFKGWMDIMYAAVD 1224
Query 661 AYRRYSGPWSKI------YFVLWWLVSSVIWVNLFLALILENF 697
+ P +I YFV++ + + +NLF+ +I++NF
Sbjct 1225 SREVEDQPIYEINVYMYLYFVIFIVFGAFFTLNLFIGVIIDNF 1267
Score = 43.9 bits (102), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 94/460 (20%), Positives = 168/460 (37%), Gaps = 121/460 (26%)
Query 348 GGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVL--LSAEEFQKLFNELDR 405
G P G P++LL + + LD +K V S G+++ +AE +F+ +
Sbjct 52 GKPLPMIYGDPPEDLLNIPLE-DLDPFYKTQKTFIVISKGNIINRFNAERALYIFSPFN- 109
Query 406 SVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD 465
P + A +F + F N + + S C+F+ + PA
Sbjct 110 --------------PIRRGAIRVFVNSAF----NFFIMFTIFSNCIFMTISNP--PAWSK 149
Query 466 DFILGILNCVFIVYYLLEMLLKV----FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
I+ F Y E+++KV F +G +L P N D + + + E L
Sbjct 150 -----IVEYTFTGIYTFEVIVKVLSRGFCIGHFTFLRDPWNWLDFSVVTMTYITEFIDL- 203
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
R ++ L FR LR + ++ + + + V L+++M+
Sbjct 204 -----------------------RNVSALRTFRVLRALKTITIFPGLKTIVRALIESMKQ 240
Query 582 FGGILVVVYY---VFAIIGINLFRGVI--------------------------------- 605
G ++++ + VF + G+ LF G +
Sbjct 241 MGDVVILTVFSLAVFTLAGMQLFMGNLRHKCIRWPISNVTLDYESAYNTTFDFTAYIENE 300
Query 606 -----------VALPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNL 649
L GN+S A G P G + Y N+D+FA + L+ L
Sbjct 301 ENQYFLDGALDALLCGNNSDA---GKCPEGYTCMKAGRNPNYGYTNYDNFAWTFLCLFRL 357
Query 650 MVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
M+ + W+ R +G ++F++ + S +NL LA++ + +
Sbjct 358 MLQDYWENLYQMTLRAAGKSYMVFFIMVIFLGSFYLINLILAVVAMAYEEQ---NQATLA 414
Query 710 LAGTPEATYQMTVELLFRDILEEPGEDE----LTERLSQH 745
A EA +Q VE L I +E DE L +L+Q+
Sbjct 415 EAQEKEAEFQRAVEQL--RIQQEQINDERKASLASQLTQN 452
Score = 38.1 bits (87), Expect = 0.43, Method: Compositional matrix adjust.
Identities = 69/359 (19%), Positives = 140/359 (39%), Gaps = 67/359 (19%)
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
++Y +FFI+ +GS +L+NL+ A++ + +L + + RA ++ +
Sbjct 376 KSYMVFFIMVIFLGSFYLINLILAVVAMAYEEQNQATLAEAQEKEAEFQRAVEQL--RIQ 433
Query 346 GEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMME---------KVRSYGSVLLSAEEF 396
E + + Q L Q+ ++ A+ E +R SV LS EE
Sbjct 434 QEQINDERKASLASQ--LTQNQEAEITDDGDDAIKECNGKAFPLANIREPSSVKLSTEEQ 491
Query 397 QKLFNELDRSVVKEHPPRPEYQSPF--------LQSAQ-------FLFGHYYFDY--LGN 439
+ +D + P + L++A+ + F + F + G
Sbjct 492 RSDSKSMDSKHSVDKPSLKHKAASTMSVFTLEDLEAARRPCPPVWYKFAGFVFKWNCCGP 551
Query 440 LIALAN-------------LVSICVFL---VLDADVLP-AERDDFILGILNCVFIVYYLL 482
+ L +++C+ L + + P E +L N VF +
Sbjct 552 WVFLKKWVHFVMMDPFTDLFITLCIILNTLFMSIEHHPMNESFQSLLSAGNLVFTTIFAA 611
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
EM+LK+ AL Y N+FD ++ + L+ + M G+ L
Sbjct 612 EMVLKIIALDPYYYFQQTWNIFDSIIVSLSLLELGLS-------------NMQGMSVL-- 656
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
R L +L +F+ + P++ ++ + +G + N+ +L ++ ++FA++G LF
Sbjct 657 --RSLRLLRIFKLAKSWPTLNILIKIICNSVGALGNLTI---VLAIIVFIFALVGFQLF 710
Score = 35.4 bits (80), Expect = 2.6, Method: Compositional matrix adjust.
Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query 143 KGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMM 202
+G+ G F ++ W +L VV++ T + L LR R+LR + +
Sbjct 170 RGFCIGHFTFLRDPW--NWLDFSVVTMTYITEFIDLRNVSALRTFRVLRALKTITIFPGL 227
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
K ++ + S+ +M V +L L +FT+ GM LF G
Sbjct 228 KTIVRALIESMKQMGDVVILTVFSLAVFTLAGMQLFMGN 266
>sp|Q9Y5Y9|SCNAA_HUMAN Sodium channel protein type 10 subunit
alpha OS=Homo sapiens OX=9606 GN=SCN10A PE=1 SV=2
Length=1956
Score = 60.8 bits (146), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 129/620 (21%), Positives = 249/620 (40%), Gaps = 123/620 (20%)
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SL 178
L E + + +F ++ +K +G+ + N W +++ +SL+ T + +
Sbjct 1184 ALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEV 1243
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LF
Sbjct 1244 APIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1303
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI 298
AG + N + SL+ L N D I +N + F++ V
Sbjct 1304 AG----------KFWRCINYTDGEFSLVPLSIVNNKSDCKI----QNSTGSFFWVNVKVN 1349
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAF 351
M L + + F+G+ M + ++ R + + +E M + GG F
Sbjct 1350 FDNVAMGYLALLQVATFKGW-MDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFF 1408
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVK 409
L + V +D+ ++Q K + G + EE +K +N + + S
Sbjct 1409 ----------TLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1454
Query 410 EHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD-- 466
+ P PRP + F + FD + A ++I V + L+ + E DD
Sbjct 1455 QKPIPRPLNK----------FQGFVFDIVTRQ---AFDITIMVLICLNMITMMVETDDQS 1501
Query 467 ----FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
ILG +N F+ + E ++K+FAL + Y + NVFD + VVL + + A+
Sbjct 1502 EEKTKILGKINQFFVAVFTGECVMKMFAL-RQYYFTNGWNVFD-FIVVVLSIASLIFSAI 1559
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
+ + P + ++ L + R+L ++ + +R + +M++ A +GL
Sbjct 1560 LKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGL------- 1612
Query 583 GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN-----NFD 637
+L +V ++++I G++ SF + + A NF
Sbjct 1613 --LLFLVMFIYSIFGMS-------------------------SFPHVRWEAGIDDMFNFQ 1645
Query 638 DFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK--------------------IYFVLW 677
FA +++ L+ + W L P+ I+F +
Sbjct 1646 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTY 1705
Query 678 WLVSSVIWVNLFLALILENF 697
++S +I VN+++A+ILENF
Sbjct 1706 IIISFLIMVNMYIAVILENF 1725
Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 63/262 (24%), Positives = 106/262 (40%), Gaps = 67/262 (26%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VF V Y E L+K+ A G YL P N D +V L + G
Sbjct 159 VFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLD--------------FSVITLAYVGT 204
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
++ G+ L R +L + + +IP +K++ V L+ +++ + ++
Sbjct 205 AIDLRGISGL----RTFRVLRALKTVSVIPGLKVI------VGALIHSVKKLADVTILTI 254
Query 591 Y---VFAIIGINLFRG--------------------------VIVALPGNSS-LAPANGS 620
+ VFA++G+ LF+G + + G S L NGS
Sbjct 255 FCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGS 314
Query 621 ----APCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
P G + + ++ +FD FA A ++L+ LM ++W+ R SG
Sbjct 315 DSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYM 374
Query 672 IYFVLWWLVSSVIWVNLFLALI 693
I+FVL + S VNL LA++
Sbjct 375 IFFVLVIFLGSFYLVNLILAVV 396
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 56/235 (24%), Positives = 102/235 (43%), Gaps = 42/235 (18%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL-TVVLLVLEISTLAVYRLP 526
+L I N VF +++ EM+ K+ A Y N+FD ++ TV LL L ++
Sbjct 696 MLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAK------- 748
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
G LS+ R +L VF+ + P++ + + +G + N+ IL
Sbjct 749 --------KGSLSVL---RSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTI---IL 794
Query 587 VVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
++ +VFA++G L L N N SAP E W + DF + + +
Sbjct 795 AIIVFVFALVGKQL-------LGENYRNNRKNISAP---HEDWPRW--HMHDFFHSFLIV 842
Query 647 WNLM----VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ ++ + N W + I F+ ++ +++ +NLF+AL+L +F
Sbjct 843 FRILCGEWIENMWACMEVGQKSI----CLILFLTVMVLGNLVVLNLFIALLLNSF 893
Score = 33.9 bits (76), Expect = 7.4, Method: Compositional matrix adjust.
Identities = 61/276 (22%), Positives = 114/276 (41%), Gaps = 32/276 (12%)
Query 134 LVFAADLSVKGYLFG-WAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRR 188
+ F A++ K F + +FQK W + +++ VSL++ V SLS+ LR R
Sbjct 706 IFFTAEMVFKIIAFDPYYYFQKK-WNIFDCIIVTVSLLELGVAKKGSLSV-----LRSFR 759
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ ++LAI + +F + G L +++
Sbjct 760 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKN 819
Query 246 ----GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSL 301
+D R L +L + I F+ V+G+L
Sbjct 820 ISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNL 879
Query 302 FLMNLLTAIIYSQFRGYLM---------KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFP 352
++NL A++ + F + +LQ +L R ++ + L S FP
Sbjct 880 VVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFP 939
Query 353 QAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGS 388
Q P+ +++ K+ L SS + + + GS
Sbjct 940 Q-----PKAEPELVVKLPLSSSKAENHIAANTARGS 970
>sp|C9D7C2|CAC1A_APIME Voltage-dependent calcium channel type
A subunit alpha-1 OS=Apis mellifera OX=7460 GN=CAC PE=2 SV=1
Length=1904
Score = 60.8 bits (146), Expect = 5e-08, Method: Compositional matrix adjust.
Identities = 102/503 (20%), Positives = 199/503 (40%), Gaps = 72/503 (14%)
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA------YSKNRA 287
GM LF G Q + T F P +L ++ +LT + +VM + K
Sbjct 712 GMQLFGG--QFNFDSGTPPTNFNTFPIALLTVFQILTGEDWNEVMYQGIESQGGHKKGMI 769
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGE 347
Y+++FIV + G+ L+N+ AI A E+ ++ E
Sbjct 770 YSLYFIVLVLFGNYTLLNVFLAIAVDNLAN-------------------AQELSAAENEE 810
Query 348 GGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSV 407
Q + + +Q LQ + + K +E G + E +K +E D +
Sbjct 811 EEEDKQKQAQEIEKEIQSLQNPKDGGAPK---VEICPPNGKGGKQSSEEEKKQDEDDDTG 867
Query 408 VKEHPPRPEY-----QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
K P +P ++A ++ YFD+ ++ + +L SI L + V
Sbjct 868 PKPMLPYSSMFILSPTNPVRRAAHWVVNLRYFDFF--IMVVISLSSIA--LAAEDPVWED 923
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
+ +L + F + +EM+LK+ LG+ + +P + ++ V+ I
Sbjct 924 SPRNEVLNYFDYAFTGVFTVEMILKIIDLGI---ILHPGSYLREFWNIMDAVVVICAAVS 980
Query 523 YRLPHPGWRPEMVGLLSLWDMT--RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+ +M G + +++ + L +L V R L+ I + + V V+ ++N+
Sbjct 981 FAF-------DMTGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVI 1033
Query 581 AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE--------QLEYW 632
+ ++ ++FA+I + LF G S + FE + W
Sbjct 1034 NILIVYILFQFIFAVIAVQLFNGKFFYCSDESKYTQQDCQGQYFVFEDGALLPEPKKREW 1093
Query 633 ANNF---DDFAAALVTLWNLMVVNNW----QVFLDAYRRYSGPWSK------IYFVLWWL 679
+ F D+ AA++TL+ + W Q + A GP I+++++++
Sbjct 1094 QSQFFHYDNVMAAMLTLFAVQTGEGWPQILQNSMAATYEDKGPIQNFRIEMSIFYIVYFI 1153
Query 680 VSSVIWVNLFLALILENFLHKWD 702
V +VN+F+ALI+ F + +
Sbjct 1154 VFPFFFVNIFVALIIITFQEQGE 1176
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 56/246 (23%), Positives = 104/246 (42%), Gaps = 54/246 (22%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L +N F + +E +LK+ A G+R + N FD +TV+ +++ +
Sbjct 1255 LKYMNMCFTGMFTVECILKIAAFGVRNFFKDAWNTFD-FITVIGSIVDALVIEF------ 1307
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G VG L L+ R++ +L +RI+ + VQ+ +A + ++
Sbjct 1308 GENFINVGFLRLFRAARLIKLLRQGYTIRIL------------LWTFVQSFKALPYVCLL 1355
Query 589 V---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++AIIG+ +F +AL ++S+ NNF F L+
Sbjct 1356 IAMLFFIYAIIGMQVFGN--IALDADTSITK----------------HNNFQSFIQGLML 1397
Query 646 LWNLMVVNNWQVFL-----------DAYRRYSGPWSKI---YFVLWWLVSSVIWVNLFLA 691
L+ W + A ++ G S I YFV + S + +NLF+A
Sbjct 1398 LFRCATGEAWPNIMLSCVKGRPCDAKAGKQEGGCGSNIAYAYFVSFIFFCSFLMLNLFVA 1457
Query 692 LILENF 697
+I++NF
Sbjct 1458 VIMDNF 1463
Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 57/230 (25%), Positives = 97/230 (42%), Gaps = 47/230 (20%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF+ ++LEM +KV+ALG R Y N FD +V+ S V W
Sbjct 606 VFLALFMLEMFIKVYALGPRTYFDSSFNRFD------CVVISGSIFEVI------WSEVK 653
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYY 591
G L++L R LRI K + + V+ L+ +MR + +L +
Sbjct 654 SGSFG-------LSVLRALRLLRIFKVTKYWKSLRNLVISLLSSMRSIISLLFLLFLFIL 706
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+FA++G+ LF G +G+ P NF+ F AL+T++ ++
Sbjct 707 IFALLGMQLFGG---------QFNFDSGTPP-----------TNFNTFPIALLTVFQILT 746
Query 652 VNNWQVFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W + G K +YF++ L + +N+FLA+ ++N
Sbjct 747 GEDWNEVMYQGIESQGGHKKGMIYSLYFIVLVLFGNYTLLNVFLAIAVDN 796
Score = 42.0 bits (97), Expect = 0.028, Method: Compositional matrix adjust.
Identities = 73/314 (23%), Positives = 126/314 (40%), Gaps = 64/314 (20%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV---FIVYYLLEMLLKVFA 490
F+Y L +AN CV L L+ + LP + + L F+ + +E LK+ A
Sbjct 170 FEYAVLLTIIAN----CVVLALE-EHLPKQDKTILAQKLEATEIYFLGIFCVEASLKILA 224
Query 491 LGL---RG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LG RG YL N+ D + V + S G+ D+ R
Sbjct 225 LGFVLHRGSYLRNIWNIMDFFVVVTGFITAFSQ----------------GIELDMDL-RT 267
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG--- 603
L + V R L+++ + + VV +++ + + G +++ +FAIIG+ + G
Sbjct 268 LRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGTLH 327
Query 604 ----------VIV-----ALP---GNSSLAP-------ANGSAPCGSFEQLEYWANNFDD 638
VIV A P N S AP AN S +E + +FD+
Sbjct 328 KTCYSIRDINVIVKEGEQASPCNTDNKSEAPFGAHVCDANISTCMDHWEGPNFGITSFDN 387
Query 639 FAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
A++T++ + + W L DA ++ IYF+ ++ S +NL L ++
Sbjct 388 IGFAMLTVFQCITMEGWTAILYWTNDA---LGSTYNWIYFIPLIVLGSFFMLNLVLGVLS 444
Query 695 ENFLHKWDPRSHLQ 708
F + + + Q
Sbjct 445 GEFAKEREKVENRQ 458
Score = 41.2 bits (95), Expect = 0.046, Method: Compositional matrix adjust.
Identities = 28/121 (23%), Positives = 61/121 (50%), Gaps = 6/121 (5%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC 180
E+ E+ L +F + S+K G++ + +N+W ++ + VV+ + ++ + L
Sbjct 204 EATEIYFLGIFCVEASLKILALGFVLHRGSYLRNIWNIMDFFVVVTGFITAFSQGIELDM 263
Query 181 H-EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR R+LRP L+ ++ LK I ++ + +GLL+ + +F + G+ ++
Sbjct 264 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 323
Query 240 G 240
G
Sbjct 324 G 324
Score = 40.8 bits (94), Expect = 0.055, Method: Compositional matrix adjust.
Identities = 51/205 (25%), Positives = 83/205 (40%), Gaps = 28/205 (14%)
Query 130 VLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV---SLSLVCHEPLRI 186
V C+L AA FG +F K+ W + ++ S+VD V + + LR+
Sbjct 1268 VECILKIAA--------FGVRNFFKDAWNTFDFITVIGSIVDALVIEFGENFINVGFLRL 1319
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R R LL+ ++ L S + V LL+A+ ++ + GM +F D
Sbjct 1320 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDAD 1379
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMI------PAYSK----------NRAYAI 290
+ FQ+ + L L T P++M+ P +K N AYA
Sbjct 1380 TSITKHNNFQSFIQGLMLLFRCATGEAWPNIMLSCVKGRPCDAKAGKQEGGCGSNIAYA- 1438
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQF 315
+F+ F S ++NL A+I F
Sbjct 1439 YFVSFIFFCSFLMLNLFVAVIMDNF 1463
>sp|P35500|SCNA_DROME Sodium channel protein para OS=Drosophila
melanogaster OX=7227 GN=para PE=2 SV=3
Length=2131
Score = 60.5 bits (145), Expect = 6e-08, Method: Compositional matrix adjust.
Identities = 131/601 (22%), Positives = 245/601 (41%), Gaps = 118/601 (20%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRL 189
++F ++ +K G+ + N W V+++VSL+++ SL + + +R R
Sbjct 1344 VIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRA 1403
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP + M+ + + ++P + +V L+ I +F + G+ LFAG
Sbjct 1404 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG--------- 1454
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
YF+ + T L + N S+N + + F +G+ +L A
Sbjct 1455 ---KYFKCEDMNGTKLSHEIIPNRNA-----CESENYTWVNSAMNFDHVGNAYLCLFQVA 1506
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNL 362
F+G++ + + ++ R + + E M + G F
Sbjct 1507 T----FKGWI-QIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFF----------T 1551
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP----PRPEYQ 418
L + V +D+ ++Q K ++ GS+ + E QK + + + + P PRP ++
Sbjct 1552 LNLFIGVIIDNFNEQ----KKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWR 1607
Query 419 SPFLQSAQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
Q+ F + FD + L N+ ++ + +D A +L LN +F+
Sbjct 1608 P---QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNA-----VLDYLNAIFV 1659
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVG 536
V + E LLK+FAL Y P N+FD VV+++L I L + + + P ++
Sbjct 1660 VIFSSECLLKIFALRYH-YFIEPWNLFD----VVVVILSILGLVLSDIIEKYFVSPTLL- 1713
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI---LVVVYYVF 593
R++ + V R LR++ K + + + L ++ A I L +V ++F
Sbjct 1714 --------RVVRVAKVGRVLRLVKGAK---GIRTLLFALAMSLPALFNICLLLFLVMFIF 1762
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
AI G++ F V N NF F +++ L+ +
Sbjct 1763 AIFGMSFFMHVKEKSGIND--------------------VYNFKTFGQSMILLFQMSTSA 1802
Query 654 NWQVFLDAY------------RRYSGPWSK----IYFVLWWLVSS-VIWVNLFLALILEN 696
W LDA + Y G I F+L +LV S +I +N+++A+ILEN
Sbjct 1803 GWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILEN 1862
Query 697 F 697
+
Sbjct 1863 Y 1863
Score = 57.0 bits (136), Expect = 7e-07, Method: Compositional matrix adjust.
Identities = 66/248 (27%), Positives = 110/248 (44%), Gaps = 36/248 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL ++ +F V + LEML+K ALG + Y + D ++ +V L+ +++L
Sbjct 1334 ILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLV------ 1387
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
G + + R L L R LR + M+ M VV V LVQ + + +L+
Sbjct 1388 ------GAGGIQAFKTMRTLRAL---RPLRAMSRMQGMRVV---VNALVQAIPSIFNVLL 1435
Query 588 VV---YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC-GSFEQLEY-WAN---NFDDF 639
V + +FAI+G+ LF G + ++ P + E Y W N NFD
Sbjct 1436 VCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHV 1495
Query 640 AAALVTLWNLMVVNNW-QVFLDAYR---------RYSGPWSKIYFVLWWLVSSVIWVNLF 689
A + L+ + W Q+ DA R + + +YFV + + S +NLF
Sbjct 1496 GNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555
Query 690 LALILENF 697
+ +I++NF
Sbjct 1556 IGVIIDNF 1563
Score = 41.2 bits (95), Expect = 0.040, Method: Compositional matrix adjust.
Identities = 40/193 (21%), Positives = 80/193 (41%), Gaps = 46/193 (24%)
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRG 603
L L FR LR + ++ ++ + + V ++++++ ++++ + VFA++G+ ++ G
Sbjct 236 LAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMG 295
Query 604 VIVA-------LPG---------------NSS-------------LAPANGSAPC----- 623
V+ L G NSS +G+ C
Sbjct 296 VLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYV 355
Query 624 ---GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLV 680
G Y +FD F A ++ + LM + W+ R +GPW ++F++ +
Sbjct 356 CLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFL 415
Query 681 SSVIWVNLFLALI 693
S VNL LA++
Sbjct 416 GSFYLVNLILAIV 428
Score = 37.4 bits (85), Expect = 0.67, Method: Compositional matrix adjust.
Identities = 56/256 (22%), Positives = 117/256 (46%), Gaps = 38/256 (15%)
Query 87 SFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYL 146
F I ++LF+ + T T D RY A+ + + + + + +++F+++ +K +
Sbjct 1620 KFDIIIMLFIGL----NMFTMTLD-RYDAS--DTYNAVLDYLNAIFVVIFSSECLLKIFA 1672
Query 147 FGWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLVCHEPLRIRRLLRPFFLLQNS 199
+ +F + W L +VV+++S++ +S +S +R+ ++ R L++ +
Sbjct 1673 LRYHYFIEP-WNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1731
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLP 259
++ L + SLP + ++ LLL + + +F +FGM F K+ G + + F+
Sbjct 1732 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGIN--DVYNFKTFG 1789
Query 260 ESLTSLLVLLTTAN--------------NPDVMIPAYSKNRAYA----IFFIVFTVIGSL 301
+S+ L + T+A +P Y N A F + + VI L
Sbjct 1790 QSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFL 1849
Query 302 FLMNLLTAII---YSQ 314
++N+ A+I YSQ
Sbjct 1850 IVINMYIAVILENYSQ 1865
>sp|Q9UI33|SCNBA_HUMAN Sodium channel protein type 11 subunit
alpha OS=Homo sapiens OX=9606 GN=SCN11A PE=1 SV=2
Length=1791
Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust.
Identities = 63/244 (26%), Positives = 115/244 (47%), Gaps = 47/244 (19%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTL--AVYRL 525
IL LN VF+V + LE L+K+FAL + Y + N+FD VV+L+ +ST+ +
Sbjct 1397 ILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFD---CVVVLLSIVSTMISTLENQ 1452
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
H + P + ++ L + R+L ++ R +R + +M++ + +GL +
Sbjct 1453 EHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGL---------L 1503
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
L ++ +++AI+G+N F S + P +G NF FA++++
Sbjct 1504 LFLIMFIYAILGMNWF----------SKVNPESGIDDIF----------NFKTFASSMLC 1543
Query 646 LWNLMVVNNWQVFLDAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALI 693
L+ + W L R + YFV + ++S +I VN+++A+I
Sbjct 1544 LFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVI 1603
Query 694 LENF 697
LENF
Sbjct 1604 LENF 1607
Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 56/260 (22%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query 447 VSIC-----VFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPS 501
++IC VFL ++ + A + +L I N VF ++ EM LK+ AL Y
Sbjct 583 ITICIIINTVFLAMEHHKMEASFEK-MLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGW 641
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPS 561
N+FD ++ ++ ++ + R W R +L VF+ + P+
Sbjct 642 NIFDSIVALLSFADVMNCVLQKR---------------SWPFLRSFRVLRVFKLAKSWPT 686
Query 562 MKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
+ + + +G + ++ +LV+V ++F+++G+ LF + P +
Sbjct 687 LNTLIKIIGNSVGALGSLTV---VLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTV 743
Query 622 PCGSFEQLEYWANNFDDFAAALVTLWNLM----VVNNWQVFLDAYRRYSGPWSKIYFVLW 677
C L +W + DF + + ++ ++ + N W+ +A S I F+L
Sbjct 744 SC-----LRHW--HMGDFWHSFLVVFRILCGEWIENMWECMQEA--NASSSLCVIVFILI 794
Query 678 WLVSSVIWVNLFLALILENF 697
++ ++ +NLF+AL+L +F
Sbjct 795 TVIGKLVVLNLFIALLLNSF 814
Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 60/277 (22%), Positives = 109/277 (39%), Gaps = 41/277 (15%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP 183
L +++ +F ++ +K FG+ + + W ++++VS+ T ++L+ +
Sbjct 1089 LLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSV---TTLINLMELKS 1145
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--G 241
R R LRP L MK + + ++P + +V L+ I +F + G+ F+G G
Sbjct 1146 FRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFG 1205
Query 242 KQDDGQDR---------------------ERLTYFQNLPESLTSLLVLLTTANNPDVMI- 279
K +G D + F N+ + +LL + T D++
Sbjct 1206 KCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYA 1265
Query 280 ----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFR 329
P + N I+F+VF + GS F +NL +I F K +F
Sbjct 1266 AVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFM 1325
Query 330 RRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
T + ++M G PQ +P N Q L
Sbjct 1326 ----TEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGL 1358
Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 58/257 (23%), Positives = 107/257 (42%), Gaps = 48/257 (19%)
Query 463 ERDDFILGILNCVFIVY---YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
E I +LNC I++ ++LEM+LK A G Y + D +++++ ++T
Sbjct 1081 ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLD----FIIVIVSVTT 1136
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
L + L+ L + L R LR + + M VV + ++G + +
Sbjct 1137 L--------------INLMEL----KSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAI 1178
Query 580 RAFGGILVVVYYVFAIIGINLFRGVI-VALPG-----NSSLAPANGSAPCGSFEQLEYWA 633
+ ++ + VF I+G+ F G + G N ++ G+F W
Sbjct 1179 LNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFS----WI 1234
Query 634 N---NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSK------IYFVLWWLV 680
N NFD+ A + L + W + D+ + P + IYFV++ +
Sbjct 1235 NQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIF 1294
Query 681 SSVIWVNLFLALILENF 697
S +NLF+ +I++NF
Sbjct 1295 GSFFTLNLFIGVIIDNF 1311
Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 52/262 (20%), Positives = 104/262 (40%), Gaps = 62/262 (24%)
Query 471 ILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLP 526
I CVF Y+ E L+K+ A G +L P N D ++ + +V I + + LP
Sbjct 161 IAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP 220
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
L FR R + ++ +++ + V L+++++ ++
Sbjct 221 -----------------------LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVI 257
Query 587 VVVYY---VFAIIGINLFRGVI-VALPGNSSLAPANGSAPCGSFEQLE------------ 630
++ ++ +FA++G LF G + + +N A FE+ E
Sbjct 258 ILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWM 317
Query 631 -------------------YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
Y NFD+F + + ++ LM ++W+ R +G +S
Sbjct 318 GNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSV 377
Query 672 IYFVLWWLVSSVIWVNLFLALI 693
+F++ + S +NL LA++
Sbjct 378 FFFIVVIFLGSFYLINLTLAVV 399
Score = 37.7 bits (86), Expect = 0.56, Method: Compositional matrix adjust.
Identities = 48/198 (24%), Positives = 89/198 (45%), Gaps = 19/198 (10%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP-LRIRRLLRPF 193
+F A++ +K H+ + W + +V ++S D + P LR R+LR F
Sbjct 619 IFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVF 678
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLT 253
L ++ + +K I S+ + S+ ++L I + +F++ GM LF G+ + Q +L
Sbjct 679 KLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF--GRSFNSQKSPKLC 736
Query 254 ----------YFQNLPESLTSLLVLLTT------ANNPDVMIPAYSKNRAYAIFFIVFTV 297
++ + S LV+ N + M A + + I FI+ TV
Sbjct 737 NPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITV 796
Query 298 IGSLFLMNLLTAIIYSQF 315
IG L ++NL A++ + F
Sbjct 797 IGKLVVLNLFIALLLNSF 814
Score = 36.6 bits (83), Expect = 1.1, Method: Compositional matrix adjust.
Identities = 44/205 (21%), Positives = 91/205 (44%), Gaps = 25/205 (12%)
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-LSLVCHEP-------- 183
+++F + +K + +F N W L VV+++S+V +S L H P
Sbjct 1406 VVIFTLECLIKIFALRQYYFT-NGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++ + GM F+
Sbjct 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-------------AI 290
+ G D + F+ S+ L + T+A ++ P +
Sbjct 1525 ESGID--DIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQF 315
+F+ + +I L ++N+ A+I F
Sbjct 1583 YFVSYIIISFLIVVNMYIAVILENF 1607
>sp|Q9WTU3|SCN8A_MOUSE Sodium channel protein type 8 subunit alpha
OS=Mus musculus OX=10090 GN=Scn8a PE=1 SV=1
Length=1978
Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 127/601 (21%), Positives = 249/601 (41%), Gaps = 111/601 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ F N W L +L+V V VSL+ + S L + LR R L
Sbjct 1240 IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL 1299
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1300 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1349
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ Y N + + + + + ++ + + I F +G+ +L L A
Sbjct 1350 KYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT 1409
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQN 361
F+G+ M + ++ R+ + +E V+ + G +GV N
Sbjct 1410 ----FKGW-MDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDN 1464
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQ 418
Q +K + G + EE +K +N + + S + P PRP +
Sbjct 1465 FNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1508
Query 419 SPFLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+Q F F FD + ++ N+V+ ++++ D + ++ IL +N VF+
Sbjct 1509 ---IQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWINLVFV 1560
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVG 536
+++ E +LK+FAL Y + N+FD V+++L I + + + + P +
Sbjct 1561 IFFTCECVLKMFAL-RHYYFTIGWNIFD----FVVVILSIVGMFLADIIEKYFVSPTLFR 1615
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
++ L + R+L ++ + +R + +M++ A +GL +L +V ++F+I
Sbjct 1616 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIFSIF 1666
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G++ F V G + NF+ F +++ L+ + W
Sbjct 1667 GMSNFAYV---------------KHEAGIDDMF-----NFETFGNSMICLFQITTSAGWD 1706
Query 657 VFL--------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILEN 696
L D P S +FV + ++S +I VN+++A+ILEN
Sbjct 1707 GLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILEN 1766
Query 697 F 697
F
Sbjct 1767 F 1767
Score = 53.9 bits (128), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 62/253 (25%), Positives = 104/253 (41%), Gaps = 39/253 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEMLLK A G + + D L+ V LV I+ Y
Sbjct 1229 ILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---- 1284
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
S + L L R LR + + M VV + ++G + ++ + +
Sbjct 1285 -----------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCL 1333
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPC-----GSFEQLEYWAN--- 634
+ + +F+I+G+NLF G +S + N C G+ ++ W N
Sbjct 1334 IFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIR-WKNVKI 1392
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL---------DAYRRYSGP-WSKIYFVLWWLVSSVI 684
NFD+ A + L + W + D Y G + IYFV++ + S
Sbjct 1393 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFF 1452
Query 685 WVNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1453 TLNLFIGVIIDNF 1465
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 61/261 (23%), Positives = 104/261 (40%), Gaps = 78/261 (30%)
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLF-- 601
++ L FR LR + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF
Sbjct 216 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 275
Query 602 --RGVIVALP---------------------------------------GNSSLAPANGS 620
R V P GNSS A G
Sbjct 276 NLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDA---GQ 332
Query 621 APCGSFEQLE------YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF 674
P G F+ ++ Y +FD F+ A + L+ LM + W+ R +G I+F
Sbjct 333 CPEG-FQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFF 391
Query 675 VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR------- 727
VL V S VNL LA++ ++ ++ L+ A EA ++ +E L +
Sbjct 392 VLVIFVGSFYLVNLILAVVA--MAYEEQNQATLEE-AEQKEAEFKAMLEQLKKQQEEAQA 448
Query 728 ------------DILEEPGED 736
D +EE GED
Sbjct 449 AAMATSAGTVSEDAIEEEGED 469
Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust.
Identities = 40/171 (23%), Positives = 77/171 (45%), Gaps = 28/171 (16%)
Query 439 NLIALANLV--SICVFLVLDADVLPAERD------DFILGILNCVFIVYYLLEMLLKVFA 490
NLI + V +I + +VL+ + E + +L + N VF + EM LK+ A
Sbjct 745 NLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA 804
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
+ Y N+FDG + V L ++E+ V L + R +L
Sbjct 805 MDPYYYFQEGWNIFDGFI-VSLSLMELGLADVEGL----------------SVLRSFRLL 847
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 848 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 895
>sp|O60840|CAC1F_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1F OS=Homo sapiens OX=9606 GN=CACNA1F PE=1 SV=2
Length=1977
Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 54/250 (22%), Positives = 111/250 (44%), Gaps = 42/250 (17%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
++ + ILN VF + +EM+LK+ A + Y + N FD L+ VV +++I+ V
Sbjct 1219 NYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALI-VVGSIVDIAVTEVNNG 1277
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
H G E +S+ + V R ++++ + + + T + Q + +
Sbjct 1278 GHLGESSEDSSRISI----TFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 1333
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ ++++++A+IG+ +F VAL + + NNF F A++
Sbjct 1334 IAMIFFIYAVIGMQMFGK--VALQDGTQIN----------------RNNNFQTFPQAVLL 1375
Query 646 LWNLMVVNNWQVFL---------DAYRRYSGPWSKI---------YFVLWWLVSSVIWVN 687
L+ WQ + D + GP + YF+ ++++ + + +N
Sbjct 1376 LFRCATGEAWQEIMLASLPGNRCDPESDF-GPGEEFTCGSNFAIAYFISFFMLCAFLIIN 1434
Query 688 LFLALILENF 697
LF+A+I++NF
Sbjct 1435 LFVAVIMDNF 1444
Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust.
Identities = 72/291 (25%), Positives = 126/291 (43%), Gaps = 36/291 (12%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L L AN V++ V++ D + + L + VF+V + +E +LK+ A GL
Sbjct 94 FDILILLTIFANCVALGVYIPFPED--DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGL 151
Query 494 ----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
Y+ N+ D ++ VV L S L PG P G +D+ + L
Sbjct 152 VLHPSAYIRNGWNLLDFIIVVVGL---FSVLLEQGPGRPGDAPHTGGKPGGFDV-KALRA 207
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI---- 605
V R LR++ + + +V ++++ + + +++ V ++AIIG+ LF G +
Sbjct 208 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTC 267
Query 606 ------VALPGNSSLAPANGSAPCGSFEQLEYWA---------NNFDDFAAALVTLWNLM 650
+ + S ++GS + Q E NFD+F A++T++ +
Sbjct 268 YFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCV 327
Query 651 VVNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W L DA Y PW +YFV + S +NL L ++ F
Sbjct 328 TMEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEF 375
Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 57/233 (24%), Positives = 106/233 (45%), Gaps = 46/233 (20%)
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
N V + + +EMLLK++ LG Y+S N FD V +LE + + V + G
Sbjct 565 NKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFD-CFVVCGGILETTLVEVGAMQPLG--- 620
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVV 589
+++L R LRI + A +++ V L+ +M+ + +L +
Sbjct 621 --------------ISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLF 666
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+F+++G+ LF G +F+Q + FD F AL+T++ +
Sbjct 667 IIIFSLLGMQLFGGKF-------------------NFDQTHTKRSTFDTFPQALLTVFQI 707
Query 650 MVVNNWQVFL-DAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+ +W V + D Y GP+ IYF++ ++ + I +N+FLA+ ++N
Sbjct 708 LTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 760
Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 65/279 (23%), Positives = 110/279 (39%), Gaps = 60/279 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD-------DFILGI 471
+P + L H+ F L I VF++L + L AE + ILG
Sbjct 858 NPLRKGCHTLIHHHVFTNL-----------ILVFIILSSVSLAAEDPIRAHSFRNHILGY 906
Query 472 LNCVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
+ F + +E+LLK+ G RG S+ + F+ +L ++++ + + + ++
Sbjct 907 FDYAFTSIFTVEILLKMTVFGAFLHRG--SFCRSWFN-MLDLLVVSVSLISFGIHS---- 959
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
S + ++L +L V R LR I K + V V + R G I++V
Sbjct 960 ----------SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIMIV 1006
Query 589 V---YYVFAIIGINLFRGVIVALPGNSSLAPANGSA-----PCGSFE----QLEYWAN-- 634
++FA IG+ LF+G + P P G + W N
Sbjct 1007 TTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD 1066
Query 635 -NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
NFD+ +A++ L+ + W L DAY GP
Sbjct 1067 FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGP 1105
Score = 41.2 bits (95), Expect = 0.043, Method: Compositional matrix adjust.
Identities = 47/213 (22%), Positives = 85/213 (40%), Gaps = 32/213 (15%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLVCHEPLRIR 187
+F ++ +K F H+ + W +++V S+VD V+ L + RI
Sbjct 1232 LFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRIS 1291
Query 188 -------RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
R++R LL ++ L S + V LL+A+ ++ + GM +F
Sbjct 1292 ITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGK 1351
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA------------- 287
DG R FQ P+++ L T ++M+ + NR
Sbjct 1352 VALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFT 1411
Query 288 ----YAI-FFIVFTVIGSLFLMNLLTAIIYSQF 315
+AI +FI F ++ + ++NL A+I F
Sbjct 1412 CGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
>sp|Q01668|CAC1D_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Homo sapiens OX=9606 GN=CACNA1D PE=1 SV=2
Length=2161
Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 132/654 (20%), Positives = 261/654 (40%), Gaps = 144/654 (22%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L++F + +K G L + +N W L V+++V L ++V L +
Sbjct 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL--FSVILEQLTK 219
Query 182 E-----------------PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
E LR R+LRP L+ ++ L I ++ + + LL+
Sbjct 220 ETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL 279
Query 225 IHLCLFTMFGMLLFAG---------------------------GKQDDGQDRE------- 250
+ ++ + G+ LF G G+Q E
Sbjct 280 FVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVG 339
Query 251 ---RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLF 302
+T F N ++ ++ +T DV+ Y N A ++F+ + GS F
Sbjct 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVL---YWMNDAMGFELPWVYFVSLVIFGSFF 396
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
++NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 397 VLNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENE 453
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQK-----LFNELDRSVVKEHPPRPEY 417
+ ++ + ++S + E V + +S E + L + +S + R
Sbjct 454 EEGGEEGKRNTSMPTSETESVNTEN---VSGEGENRGCCGSLCQAISKSKLSRRWRRWNR 510
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+ A +Y +L ++ N ++I D L +D I N V +
Sbjct 511 FNRRRCRAAVKSVTFY--WLVIVLVFLNTLTISSEHYNQPDWLTQIQD-----IANKVLL 563
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEIST---LAVYRLPHP 528
+ EML+K+++LGL+ Y N FD G+ +L+ LEI + ++V+R
Sbjct 564 ALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRC--- 620
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
V LL ++ +TR L + + +++L ++++ + +L +
Sbjct 621 ------VRLLRIFKVTRHWTSL---------------SNLVASLLNSMKSIASLLLLLFL 659
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+F+++G+ LF G +F++ + + FD+F AL+T++
Sbjct 660 FIIIFSLLGMQLFGGKF-------------------NFDETQTKRSTFDNFPQALLTVFQ 700
Query 649 LMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
++ +W V D Y GP S IYF++ ++ + I +N+FLA+ ++N
Sbjct 701 ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Score = 55.1 bits (131), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 120/642 (19%), Positives = 253/642 (39%), Gaps = 79/642 (12%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 879 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGY---FDYAFTAIFTVEIL 935
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 936 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 995
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF GK D +
Sbjct 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK-GKFYRCTDEAKSN--- 1051
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F V+ ++ M L T + +
Sbjct 1052 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDFNFDNVLSAM--MALFTVSTFEGWP 1104
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
L K++ ++ +G + + V F + + ++ + + + +
Sbjct 1105 ALLYKAIDSN--GENIGP-----IYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1157
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P+ YQ F ++ F+Y
Sbjct 1158 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW----YVVNSSPFEY 1209
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + + + D ILN VF + +EM+LKV A +GY
Sbjct 1210 MMFVLIMLNTLCLAMQHYEQSKMFNDAMD-----ILNMVFTGVFTVEMVLKVIAFKPKGY 1264
Query 497 LSYPSNVFDGLLTVVLLV----LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
S N FD L+ + ++ E +P P P + +T + V
Sbjct 1265 FSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISIT-FFRLFRV 1323
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R ++++ + + + T + Q + ++ ++++++A+IG+ +F V +
Sbjct 1324 MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAM------ 1377
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DAYR 663
NNF F A++ L+ WQ + D
Sbjct 1378 ------------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPES 1425
Query 664 RYS--------GPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y+ ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1426 DYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 66/293 (23%), Positives = 121/293 (41%), Gaps = 40/293 (14%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L AN V++ +++ D + + L + F++ + +E LK+ A GL
Sbjct 128 FDIFILLAIFANCVALAIYIPFPED--DSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
Y+ N+ D ++ +V L +LE T H G +D+ +
Sbjct 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS------GKSGGFDV-KA 238
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI- 605
L V R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G +
Sbjct 239 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMH 298
Query 606 ------------------VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
A GN ANG+ + NFD+FA A++T++
Sbjct 299 KTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVF 358
Query 648 NLMVVNNWQVFL---DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ + W L + + PW +YFV + S +NL L ++ F
Sbjct 359 QCITMEGWTDVLYWMNDAMGFELPW--VYFVSLVIFGSFFVLNLVLGVLSGEF 409
>sp|Q9UQD0|SCN8A_HUMAN Sodium channel protein type 8 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN8A PE=1 SV=1
Length=1980
Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust.
Identities = 131/605 (22%), Positives = 248/605 (41%), Gaps = 119/605 (20%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ F N W L +L+V V VSL+ + S L + LR R L
Sbjct 1242 IFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRAL 1301
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ----DDG 246
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG +
Sbjct 1302 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS 1361
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNL 306
+ R + N E L NN ++ N F +G+ +L L
Sbjct 1362 EIRFEIEDVNNKTECEK-----LMEGNNTEIRWKNVKIN---------FDNVGAGYLALL 1407
Query 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGV 357
A F+G+ M + ++ R+ + +E V+ + G +GV
Sbjct 1408 QVAT----FKGW-MDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGV 1462
Query 358 KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PR 414
N Q +K + G + EE +K +N + + S + P PR
Sbjct 1463 IIDNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR 1506
Query 415 PEYQSPFLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
P + +Q F F FD + ++ N+V+ ++++ D + ++ IL +N
Sbjct 1507 PLNK---IQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWIN 1558
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RP 532
VF++++ E +LK+FAL Y + N+FD V+++L I + + + + P
Sbjct 1559 LVFVIFFTCECVLKMFAL-RHYYFTIGWNIFD----FVVVILSIVGMFLADIIEKYFVSP 1613
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ ++ L + R+L ++ + +R + +M++ A +GL +L +V ++
Sbjct 1614 TLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFI 1664
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
F+I G++ F V G + NF+ F +++ L+ +
Sbjct 1665 FSIFGMSNFAYV---------------KHEAGIDDMF-----NFETFGNSMICLFQITTS 1704
Query 653 NNWQVFL--------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLAL 692
W L D P S +FV + ++S +I VN+++A+
Sbjct 1705 AGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAI 1764
Query 693 ILENF 697
ILENF
Sbjct 1765 ILENF 1769
Score = 53.5 bits (127), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 61/253 (24%), Positives = 105/253 (42%), Gaps = 39/253 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEMLLK A G + + D L+ V LV I+ Y
Sbjct 1231 ILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---- 1286
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
S + L L R LR + + M VV + ++G + ++ + +
Sbjct 1287 -----------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCL 1335
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPC-----GSFEQLEYWAN--- 634
+ + +F+I+G+NLF G +S + N C G+ ++ W N
Sbjct 1336 IFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIR-WKNVKI 1394
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVI 684
NFD+ A + L + W + D+ + P + IYFV++ + S
Sbjct 1395 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFF 1454
Query 685 WVNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1455 TLNLFIGVIIDNF 1467
Score = 44.3 bits (103), Expect = 0.005, Method: Compositional matrix adjust.
Identities = 41/171 (24%), Positives = 78/171 (46%), Gaps = 28/171 (16%)
Query 439 NLIALANLV--SICVFLVLDADVLPAERD------DFILGILNCVFIVYYLLEMLLKVFA 490
NLI + V +I + +VL+ + E + +L + N VF + EM LK+ A
Sbjct 747 NLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA 806
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
+ Y N+FDG + V L ++E+S V L + R +L
Sbjct 807 MDPYYYFQEGWNIFDGFI-VSLSLMELSLADVEGL----------------SVLRSFRLL 849
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 850 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 897
Score = 43.9 bits (102), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 48/198 (24%), Positives = 79/198 (40%), Gaps = 54/198 (27%)
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLF-- 601
++ L FR LR + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF
Sbjct 216 VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 275
Query 602 --RGVIVALP---------------------------------------GNSSLAPANGS 620
R V P GNSS A G
Sbjct 276 NLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDA---GQ 332
Query 621 APCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
P G + Y +FD F+ A + L+ LM + W+ R +G I+FV
Sbjct 333 CPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFV 392
Query 676 LWWLVSSVIWVNLFLALI 693
L V S VNL LA++
Sbjct 393 LVIFVGSFYLVNLILAVV 410
>sp|Q91ZR5|CTSR1_MOUSE Cation channel sperm-associated protein
1 OS=Mus musculus OX=10090 GN=Catsper1 PE=1 SV=1
Length=686
Score = 57.4 bits (137), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 56/236 (24%), Positives = 111/236 (47%), Gaps = 36/236 (15%)
Query 464 RDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY 523
R ++ +L+ +F+ Y+LE +LK+ ALGL Y P N D +V+ VL+ L +
Sbjct 379 RGEWYFMVLDSIFLSIYVLEAVLKLIALGLE-YFYDPWNNLD-FFIMVMAVLDFVLLQIN 436
Query 524 RLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
L + + + +L ++ R L + V R L I+ S+ VA T+ G + ++ A
Sbjct 437 SLSYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLH---EVAGTLSGSLPSITAIL 493
Query 584 GILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
++ ++F+++ LF+ S P F + L
Sbjct 494 TLMFTCLFLFSVVLRALFQD----------------SDP-----------KRFQNIFTTL 526
Query 644 VTLWNLMVVNNWQ-VFLDAYRRYSGPWSKIYFVLWWLV-SSVIWVNLFLALILENF 697
TL+ ++ +++W +++D R G W I ++ ++V I++NL +A++++NF
Sbjct 527 FTLFTMLTLDDWSLIYID--NRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNF 580
Score = 33.5 bits (75), Expect = 9.0, Method: Compositional matrix adjust.
Identities = 40/146 (27%), Positives = 67/146 (46%), Gaps = 21/146 (14%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R+LR +L + + + + SLP + ++ L+ L LF++ LF Q
Sbjct 460 LRAIRVLRRLSIL---TSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALF----Q 512
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV-----FTVI 298
D R FQN+ +L +L +LT D Y NRA ++I+ + VI
Sbjct 513 DSDPKR-----FQNIFTTLFTLFTMLTL----DDWSLIYIDNRAQGAWYIIPILMIYIVI 563
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQ 324
+NL+ A++ F+ L+K L+
Sbjct 564 QYFIFLNLVIAVLVDNFQMALLKGLE 589
>sp|O35505|CAC1C_CAVPO Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Cavia porcellus OX=10141 GN=CACNA1C PE=1
SV=2
Length=2169
Score = 57.8 bits (138), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 157/679 (23%), Positives = 272/679 (40%), Gaps = 113/679 (17%)
Query 64 HRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTSTADVRYRAAP 117
HR+ S Y R ++ C+R + +L++FL F+ T + A Y
Sbjct 524 HRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNT----LTIASEHYNQPH 579
Query 118 WEPPCGLTE---SVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVV---LVVSLV 170
W LTE + L +F A++ +K Y G A+F L +V ++ +++
Sbjct 580 W-----LTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRLDCFIVCGGILETIL 634
Query 171 DWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
T +S + LR RLLR F + + + + + + S+ +AS+ LLL + + +F
Sbjct 635 VETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIF 694
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA- 289
++ GM LF GGK + + R R + F N P+SL ++ +LT + VM Y AY
Sbjct 695 SLLGMQLF-GGKFNFDEMRTRRSTFDNFPQSLLTVFQILTGEDWNSVM---YDGIMAYGG 750
Query 290 ---------IFFIVFTVIGSLFLM---------NLLTAIIYSQFRGYLMKSLQTSLFRRR 331
I+FI+ + G+ L+ NL A + + + + R
Sbjct 751 PSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLART 810
Query 332 LGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR 384
EV+ E + A G P + +Q + + ++
Sbjct 811 ASPEKKQEVVEKPAVEETKEEKIELKSITADGESPPTTKINMDDLQPNENEDKSPYPNPD 870
Query 385 SYGSVLLSAEEFQ-----KLFNELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLG 438
+ G E + +EL +KE P PE + F+ S F +
Sbjct 871 AAGEEDEEEPEMPVGPRPRPLSELH---LKEKAVPMPEASAFFIFSPNNRFRLQCHRIVN 927
Query 439 NLIALANLVSICVFLVLDADVLPAERD-------DFILGILNCVFIVYYLLEMLLKVFAL 491
+ I NL I F++L + L AE + IL + VF + +E+ LK+ A
Sbjct 928 DTI-FTNL--ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 984
Query 492 GL---RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
G +G S+ N F+ L LLV+ +S ++ G + + ++ ++L
Sbjct 985 GAFLHKG--SFCRNYFNIL---DLLVVSVSLISF------GIQSSAI------NVVKILR 1027
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIGINLFRGVI 605
+L V R LR I K + V V + R G I++V ++FA IG+ LF+G +
Sbjct 1028 VLRVLRPLRAINRAKGLKHVVQCVFVAI---RTIGNIVIVTTLLQFMFACIGVQLFKGKL 1084
Query 606 VALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMVVN 653
+S A +++ Q W N +FD+ AA++ L+ +
Sbjct 1085 YTCSDSSKQTEAECKGNYITYKDGEVDQPIIQPRSWENSKFDFDNVLAAMMALFTVSTFE 1144
Query 654 NWQVFL----DAYRRYSGP 668
W L D++ GP
Sbjct 1145 GWPELLYRSIDSHTEDKGP 1163
Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 74/306 (24%), Positives = 131/306 (43%), Gaps = 48/306 (16%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ +++ D A + L + +F++ + +E LKV A GL
Sbjct 161 LTIFANCVALAIYIPFPEDDSNATNSN--LERVEYLFLIIFTVEAFLKVIAYGLLFHPNA 218
Query 496 YLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL N+ D ++ VV L +LE +T A + G + +D+ + L V
Sbjct 219 YLRNGWNLLDFIIVVVGLFSAILEQATKA-------DGANALGGKGAGFDV-KALRAFRV 270
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV-------- 604
R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G
Sbjct 271 LRPLRLVSGVPSLQVVLNSIIKAMVPLLHTALLVLFVIIIYAIIGLELFMGKMHKTCYNQ 330
Query 605 --IVALPGNSSLAPA-----------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
I +P +P NG+ ++ ++ NFD+FA A++T++ +
Sbjct 331 EGITDVPAEEDPSPCALESGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCIT 390
Query 652 VNNWQVFL----DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPR 704
+ W L DA Y PW +YFV + S +NL L ++ F K R
Sbjct 391 MEGWTDVLYWMQDAM-GYELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKAR 447
Query 705 SHLQPL 710
Q L
Sbjct 448 GDFQKL 453
Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 64/341 (19%), Positives = 139/341 (41%), Gaps = 63/341 (18%)
Query 384 RSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIAL 443
+ Y + L + Q + L ++ + P+ ++Q ++ YF+YL ++ L
Sbjct 1204 QEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQ----YKVWYVVNSTYFEYLMFVLIL 1259
Query 444 ANLVSI--------CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
N + + C+F + + ILN +F + +EM+LK+ A +
Sbjct 1260 LNTICLAMQHYGQSCLFKI-------------AMNILNMLFTGLFTVEMILKLIAFKPKH 1306
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y N FD L+ VV +++I+ V H P M + + V R
Sbjct 1307 YFCDAWNTFDALI-VVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1365
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
++++ + + + T + Q + ++V++++++A+IG+ +F +AL + +
Sbjct 1366 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK--IALNDTTEIN 1423
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------DAY 662
NNF F A++ L+ WQ + D
Sbjct 1424 ----------------RNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESDPS 1467
Query 663 RRYSG------PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
G ++ YF+ ++++ + + +NLF+A++++NF
Sbjct 1468 NSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVVMDNF 1508
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 125/650 (19%), Positives = 250/650 (38%), Gaps = 133/650 (20%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L L++F + +K G LF + +N W L +++VV L + +
Sbjct 189 ERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD 248
Query 182 --------------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ LR R+LRP L+ ++ L I ++ + LL+ +
Sbjct 249 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHTALLVLFVI 308
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN-----NPDVMIPAY 282
++ + G+ LF G ++E +T ++P L + + N V P +
Sbjct 309 IIYAIIGLELFMGKMHKTCYNQEGIT---DVPAEEDPSPCALESGHGRQCQNGTVCKPGW 365
Query 283 S---------KNRAYA------------------------------IFFIVFTVIGSLFL 303
N A+A ++F+ + GS F+
Sbjct 366 DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFV 425
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 426 LNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENED 482
Query 364 Q-VLQKVQLDSSHKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
+ V ++ + S + E V + G + +L + + +S + R +
Sbjct 483 EGVDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNR 540
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+ + F +L + N ++I L +D N +
Sbjct 541 FCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQD-----TANKALLAL 595
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEI-STLAVYRLPHPGWRP 532
+ EMLLK+++LGL+ Y N D G+L +L+ +I S L + L
Sbjct 596 FTAEMLLKMYSLGLQAYFVSLFNRLDCFIVCGGILETILVETKIMSPLGISVL------- 648
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
V LL ++ +TR N L + + +++L V+++ + +L + +
Sbjct 649 RCVRLLRIFKITRYWNSL---------------SNLVASLLNSVRSIASLLLLLFLFIII 693
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
F+++G+ LF G +F+++ + FD+F +L+T++ ++
Sbjct 694 FSLLGMQLFGGKF-------------------NFDEMRTRRSTFDNFPQSLLTVFQILTG 734
Query 653 NNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W V D Y GP IYF++ ++ + I +N+FLA+ ++N
Sbjct 735 EDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDN 784
Score = 34.7 bits (78), Expect = 4.5, Method: Compositional matrix adjust.
Identities = 46/219 (21%), Positives = 87/219 (40%), Gaps = 38/219 (17%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV-----------SLSLVCHEP 183
+F ++ +K F H+ + W +++V S+VD + S S+ E
Sbjct 1290 LFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN 1349
Query 184 LRIR-------RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
RI R++R LL ++ L S + V LL+ + ++ + GM
Sbjct 1350 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1409
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI-------------PAYS 283
+F +D + R FQ P+++ L T D+M+ P+ S
Sbjct 1410 VFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESDPSNS 1469
Query 284 KN------RAYAIF-FIVFTVIGSLFLMNLLTAIIYSQF 315
++A+F FI F ++ + ++NL A++ F
Sbjct 1470 TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVVMDNF 1508
>sp|Q99246|CAC1D_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Mus musculus OX=10090 GN=Cacna1d PE=1
SV=3
Length=2179
Score = 57.8 bits (138), Expect = 4e-07, Method: Compositional matrix adjust.
Identities = 132/667 (20%), Positives = 263/667 (39%), Gaps = 150/667 (22%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L++F + +K G L + +N W L V+++V L ++V L +
Sbjct 162 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL--FSVILEQLTK 219
Query 182 E-----------------PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
E LR R+LRP L+ ++ L I ++ + + LL+
Sbjct 220 ETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL 279
Query 225 IHLCLFTMFGMLLFAG---------------------------GKQDDGQDRE------- 250
+ ++ + G+ LF G G+Q E
Sbjct 280 FVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVG 339
Query 251 ---RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLF 302
+T F N ++ ++ +T DV+ Y N A ++F+ ++GS F
Sbjct 340 PNGGITNFDNFAFAMLTVFQCITMEGWTDVL---YWVNDAIGWEWPWVYFVSLIILGSFF 396
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
++NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 397 VLNLVLGVLSGEFSKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENE 453
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE-EFQKLFNEL-----DRSVVKEHPPRPE 416
+ ++ + ++S + E V + +S E E Q L R K P
Sbjct 454 EEGGEEGKRNTSMPTSETESVNTEN---VSGEGETQGCCGTLWCWWKRRGAAKTGPSGCR 510
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSIC------VFLVLDADVLPAERDDF--- 467
+ ++ ++ A + S+ V + L+ + +E +
Sbjct 511 RWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDW 570
Query 468 ---ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEIS 518
I I N V + + EML+K+++LGL+ Y N FD G+ +L+ LE+
Sbjct 571 LTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELM 630
Query 519 T---LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+ ++V+R V LL ++ +TR L + + +++L
Sbjct 631 SPLGVSVFRC---------VRLLRIFKVTRHWTSL---------------SNLVASLLNS 666
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
++++ + +L + +F+++G+ LF G +F++ + +
Sbjct 667 MKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------------------NFDETQTKRST 707
Query 636 FDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLF 689
FD+F AL+T++ ++ +W V D Y GP S IYF++ ++ + I +N+F
Sbjct 708 FDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVF 767
Query 690 LALILEN 696
LA+ ++N
Sbjct 768 LAIAVDN 774
Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 111/589 (19%), Positives = 235/589 (40%), Gaps = 76/589 (13%)
Query 135 VFAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRL 189
+F ++ +K FG F +N + L ++V+ VSLV + + S + + LR+ R+
Sbjct 949 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRV 1008
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP + + +K ++C+ ++ + ++ ++ + +F G+ LF GK D
Sbjct 1009 LRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK-GKFYRCTDE 1067
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ PE L +L DV P + F V+ ++ M L T
Sbjct 1068 AKSN-----PEECRGLFILYKDG---DVDSPVVRERIWQNSDFNFDNVLSAM--MALFTV 1117
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ + L K++ ++ G V + V F + + ++ +
Sbjct 1118 STFEGWPALLYKAIDSN------GENVG-PVYNYRVEISIFFIIYIIIVAFFMMNIFVGF 1170
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q E Y + L + Q + L ++ + P+ YQ F ++
Sbjct 1171 VIVTFQEQGEKE----YKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW----YVV 1222
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y+ ++ + N + + + + + D ILN VF + +EM+LKV
Sbjct 1223 NSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMD-----ILNMVFTGVFTVEMVLKVI 1277
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLV----LEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
A +GY S N FD L+ + ++ E +P P P + +T
Sbjct 1278 AFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLPTATPGNSEESNRISIT- 1336
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+ V R ++++ + + + T + Q + ++ ++++++A+IG+ +F V
Sbjct 1337 FFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVA 1396
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL------ 659
+ NNF F A++ L+ WQ +
Sbjct 1397 M------------------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG 1438
Query 660 ---DAYRRYS--------GPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
D Y+ ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1439 KLCDPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 66/291 (23%), Positives = 120/291 (41%), Gaps = 36/291 (12%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L AN V++ +++ D + + L + F++ + +E LK+ A GL
Sbjct 128 FDIFILLAIFANCVALAIYIPFPED--DSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 185
Query 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
Y+ N+ D ++ +V L +LE T H G +D+ +
Sbjct 186 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS------GKSGGFDV-KA 238
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI- 605
L V R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G +
Sbjct 239 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMH 298
Query 606 ------------------VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
A GN ANG+ + NFD+FA A++T++
Sbjct 299 KTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVF 358
Query 648 NLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ + W L G W +YFV ++ S +NL L ++ F
Sbjct 359 QCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 134/590 (23%), Positives = 229/590 (39%), Gaps = 108/590 (18%)
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL-----RIR 187
L +F ++ VK Y G + +L+ + +V + T+ + L PL R
Sbjct 583 LALFTCEMLVKMYSLGLQAYFVSLFNR-FDCFVVCGGITETILVELELMSPLGVSVFRCV 641
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
RLLR F + ++ + + + + S+ +AS+ LLL + + +F++ GM LF GGK + +
Sbjct 642 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDE 700
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAY----SKNRAYAIFFIVFTVIGS 300
+ + + F N P++L ++ +LT + VM I AY S I+FI+ + G+
Sbjct 701 TQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGN 760
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTS-LFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
L+N+ AI +SL T+ R S+ + P+ +
Sbjct 761 YILLNVFLAIAVDNLAD--AESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIAN 818
Query 360 QNLLQVLQKVQLDSSHKQ---------AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKE 410
+ + Q D+ K E+ + A + +EL+ +KE
Sbjct 819 SDNKVTIDDYQEDAEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELN---MKE 875
Query 411 H-PPRPEYQSPFLQS--------AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLP 461
P PE + F+ S L H+ F L I VF++L + L
Sbjct 876 KIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNL-----------ILVFIMLSSAALA 924
Query 462 AERD-------DFILGILNCVFIVYYLLEMLLKVFALG--------LRGYLSYPSNVFDG 506
AE + ILG + F + +E+LLK+ G R Y N+ D
Sbjct 925 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF----NLLDM 980
Query 507 LLTVVLLV-LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
L+ V LV I + A+ + ++L +L V R LR I K +
Sbjct 981 LVVGVSLVSFGIQSSAI-------------------SVVKILRVLRVLRPLRAINRAKGL 1021
Query 566 AVVASTVLGLVQNMRAFGGILVVV---YYVFAIIGINLFRGVIVALPGNSSLAP------ 616
V V + R G I++V ++FA IG+ LF+G + P
Sbjct 1022 KHVVQCVFVAI---RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGL 1078
Query 617 ----ANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
+G + W N NFD+ +A++ L+ + W L
Sbjct 1079 FILYKDGDVDSPVVRE-RIWQNSDFNFDNVLSAMMALFTVSTFEGWPALL 1127
>sp|P15389|SCN5A_RAT Sodium channel protein type 5 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn5a PE=1 SV=1
Length=2019
Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 61/246 (25%), Positives = 102/246 (41%), Gaps = 40/246 (16%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV ++ + P
Sbjct 1247 MFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP------ 1300
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1301 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1351
Query 595 IIGINLFRGVI--------VALPGNSSLAPANGSAPCGSFEQLE--YWAN---NFDDFAA 641
I+G+NLF G LP N ++ N + C SF YW NFD+ A
Sbjct 1352 IMGVNLFAGKFGRCINQTEGDLPLNYTI--VNNKSECESFNVTGELYWTKVKVNFDNVGA 1409
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSG-----PWSK-----IYFVLWWLVSSVIWVNLFLA 691
+ L + W + A G W IYFV++ + S +NLF+
Sbjct 1410 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIG 1469
Query 692 LILENF 697
+I++NF
Sbjct 1470 VIIDNF 1475
Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 68/328 (21%), Positives = 126/328 (38%), Gaps = 88/328 (27%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++A + H F +++ + +++ CVF+ A P ++ ++
Sbjct 120 PVRRAAVKILVHSLF----SMLIMCTILTNCVFM---AQHDPPPWTKYVEYTFTAIYTFE 172
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
L+++L + F L +L P N D + V+ E L
Sbjct 173 SLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLG------------------ 214
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAII 596
++ L FR LR + ++ +++ + + V L+Q+++ ++V+ + VFA+I
Sbjct 215 ------NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALI 268
Query 597 GINLFRGVI----------------------------------------------VALPG 610
G+ LF G + V L G
Sbjct 269 GLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTTDVLLCG 328
Query 611 NSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
NSS A G+ P G + E ++ +FD FA A + L+ LM + W+ R
Sbjct 329 NSSDA---GTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRS 385
Query 666 SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
+G I+F+L + S VNL LA++
Sbjct 386 AGKIYMIFFMLVIFLGSFYLVNLILAVV 413
Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 68/285 (24%), Positives = 112/285 (39%), Gaps = 48/285 (17%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLVC 180
L E + + VF ++ +K +G+ + N W L +L+V V VSLV T+ + +
Sbjct 1240 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1299
Query 181 H-EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1300 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1359
Query 240 GG-----KQDDG----------QDRERLTY--------------FQNLPESLTSLLVLLT 270
G Q +G E ++ F N+ +LL + T
Sbjct 1360 GKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVAT 1419
Query 271 TANNPDVMI-----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
D+M P + N I+F+VF + GS F +NL +I F
Sbjct 1420 FKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK 1479
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
K +F T + ++M G PQ +P N Q
Sbjct 1480 KKLGGQDIFM----TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ 1520
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 50/217 (23%), Positives = 94/217 (43%), Gaps = 31/217 (14%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLV 179
+ +L + +F + VK +F N W + VV+++S+V +S S
Sbjct 1564 KINLLFVAIFTGECIVKMAALRHYYF-TNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1622
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++++FGM FA
Sbjct 1623 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1682
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---------- 289
K + G D + FQ S+ L + T+A ++ P + Y
Sbjct 1683 YVKWEAGID--DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGS 1740
Query 290 -----------IFFIVFTVIGSLFLMNLLTAIIYSQF 315
+FF + +I L ++N+ AII F
Sbjct 1741 RGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1777
Score = 41.2 bits (95), Expect = 0.049, Method: Compositional matrix adjust.
Identities = 65/345 (19%), Positives = 143/345 (41%), Gaps = 73/345 (21%)
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG---HYYFDYL 437
+K + G + EE +K +N + + K+ P+ P + F+F FD
Sbjct 1478 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKK--PQKPIPRPLNKYQGFIFDIVTKQAFDVT 1535
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
+ N+V++ V + D E+ + IL +N +F+ + E ++K+ AL Y
Sbjct 1536 IMFLICLNMVTMMV----ETDDQSPEKVN-ILAKINLLFVAIFTGECIVKMAAL-RHYYF 1589
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
+ N+FD ++ ++ +V + + + + + P + ++ L + R+L ++ + +R
Sbjct 1590 TNSWNIFDFVVVILSIVGTVLSDIIQKY---FFSPTLFRVIRLARIGRILRLIRGAKGIR 1646
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+ +M++ A +GL +L +V ++++I G+
Sbjct 1647 TLLFALMMSLPALFNIGL---------LLFLVMFIYSIFGM------------------- 1678
Query 618 NGSAPCGSFEQLEYWAN-----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK- 671
+F +++ A NF FA +++ L+ + W L P+
Sbjct 1679 ------ANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP 1732
Query 672 -------------------IYFVLWWLVSSVIWVNLFLALILENF 697
++F + ++S +I VN+++A+ILENF
Sbjct 1733 NLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1777
>sp|Q9JJV9|SCN5A_MOUSE Sodium channel protein type 5 subunit alpha
OS=Mus musculus OX=10090 GN=Scn5a PE=1 SV=2
Length=2019
Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust.
Identities = 61/246 (25%), Positives = 102/246 (41%), Gaps = 40/246 (16%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV ++ + P
Sbjct 1247 MFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP------ 1300
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1301 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1351
Query 595 IIGINLFRGVI--------VALPGNSSLAPANGSAPCGSFEQLE--YWAN---NFDDFAA 641
I+G+NLF G LP N ++ N + C SF YW NFD+ A
Sbjct 1352 IMGVNLFAGKFGRCINQTEGDLPLNYTI--VNNKSECESFNVTGELYWTKVKVNFDNVGA 1409
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSG-----PWSK-----IYFVLWWLVSSVIWVNLFLA 691
+ L + W + A G W IYFV++ + S +NLF+
Sbjct 1410 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIG 1469
Query 692 LILENF 697
+I++NF
Sbjct 1470 VIIDNF 1475
Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 68/328 (21%), Positives = 126/328 (38%), Gaps = 88/328 (27%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++A + H F +++ + +++ CVF+ A P ++ ++
Sbjct 119 PVRRAAVKILVHSLF----SMLIMCTILTNCVFM---AQHDPPPWTKYVEYTFTAIYTFE 171
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
L+++L + F L +L P N D + V+ E L
Sbjct 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLG------------------ 213
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAII 596
++ L FR LR + ++ +++ + + V L+Q+++ ++V+ + VFA+I
Sbjct 214 ------NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALI 267
Query 597 GINLFRGVI----------------------------------------------VALPG 610
G+ LF G + V L G
Sbjct 268 GLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCG 327
Query 611 NSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
NSS A G+ P G + E ++ +FD FA A + L+ LM + W+ R
Sbjct 328 NSSDA---GTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRS 384
Query 666 SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
+G I+F+L + S VNL LA++
Sbjct 385 AGKIYMIFFMLVIFLGSFYLVNLILAVV 412
Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 68/285 (24%), Positives = 112/285 (39%), Gaps = 48/285 (17%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLVC 180
L E + + VF ++ +K +G+ + N W L +L+V V VSLV T+ + +
Sbjct 1240 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1299
Query 181 H-EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1300 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1359
Query 240 GG-----KQDDG----------QDRERLTY--------------FQNLPESLTSLLVLLT 270
G Q +G E ++ F N+ +LL + T
Sbjct 1360 GKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVAT 1419
Query 271 TANNPDVMI-----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
D+M P + N I+F+VF + GS F +NL +I F
Sbjct 1420 FKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK 1479
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
K +F T + ++M G PQ +P N Q
Sbjct 1480 KKLGGQDIFM----TEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ 1520
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 50/217 (23%), Positives = 94/217 (43%), Gaps = 31/217 (14%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLV 179
+ +L + +F + VK +F N W + VV+++S+V +S S
Sbjct 1564 KINLLFVAIFTGECIVKMAALRHYYF-TNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1622
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++++FGM FA
Sbjct 1623 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1682
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA---------- 289
K + G D + FQ S+ L + T+A ++ P + Y
Sbjct 1683 YVKWEAGID--DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGS 1740
Query 290 -----------IFFIVFTVIGSLFLMNLLTAIIYSQF 315
+FF + +I L ++N+ AII F
Sbjct 1741 RGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1777
Score = 41.2 bits (95), Expect = 0.049, Method: Compositional matrix adjust.
Identities = 64/345 (19%), Positives = 144/345 (42%), Gaps = 73/345 (21%)
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG---HYYFDYL 437
+K + G + EE +K +N + + K+ P+ P + F+F FD
Sbjct 1478 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKK--PQKPIPRPLNKYQGFIFDIVTKQAFDVT 1535
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
+ N+V+ ++++ D E+ + IL +N +F+ + E ++K+ AL Y
Sbjct 1536 IMFLICLNMVT----MMVETDDQSPEKVN-ILAKINLLFVAIFTGECIVKMAAL-RHYYF 1589
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
+ N+FD ++ ++ +V + + + + + P + ++ L + R+L ++ + +R
Sbjct 1590 TNSWNIFDFVVVILSIVGTVLSDIIQKY---FFSPTLFRVIRLARIGRILRLIRGAKGIR 1646
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+ +M++ A +GL +L +V ++++I G+
Sbjct 1647 TLLFALMMSLPALFNIGL---------LLFLVMFIYSIFGM------------------- 1678
Query 618 NGSAPCGSFEQLEYWAN-----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK- 671
+F +++ A NF FA +++ L+ + W L P+
Sbjct 1679 ------ANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP 1732
Query 672 -------------------IYFVLWWLVSSVIWVNLFLALILENF 697
++F + ++S +I VN+++A+ILENF
Sbjct 1733 NLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENF 1777
>sp|Q99244|CAC1D_MESAU Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Mesocricetus auratus OX=10036 GN=CACNA1D
PE=2 SV=2
Length=1610
Score = 56.6 bits (135), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 132/652 (20%), Positives = 263/652 (40%), Gaps = 140/652 (21%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E VE L++F + +K G L + +N W L V+++V L ++V L +
Sbjct 161 EKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL--FSVILEQLTK 218
Query 182 E-----------------PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
E LR R+LRP L+ ++ L I ++ + + LL+
Sbjct 219 ETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL 278
Query 225 IHLCLFTMFGMLLFAG--------------GKQD------DGQDRE-------------- 250
+ ++ + G+ LF G ++D G R+
Sbjct 279 FVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVG 338
Query 251 ---RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLF 302
+T F N ++ ++ +T DV+ Y N A ++F+ + GS F
Sbjct 339 PNGGITNFDNFAFAMLTVFQCITMEGWTDVL---YWMNDAMGFELPWVYFVSLVIFGSFF 395
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
++NL+ ++ +F K+ F++ R ++ + G QA + P+N
Sbjct 396 VLNLVLGVLSGEFSKEREKAKARGDFQK---LRENEQLEEDLKGYLDWITQAEDIDPENE 452
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE-EFQKLFNELDRSVVKEHPPRPEYQSPF 421
+ ++ + ++S + E V + +S E E Q L +++ K R +
Sbjct 453 EEGGEEGKRNTSMPTSETESVNTEN---VSGEGETQGSCGSLCQAISKSKLSRRWRRWNR 509
Query 422 LQSAQFLFG--HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+ F +L ++ N ++I D L +D I N V +
Sbjct 510 FNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQD-----IANKVLLAL 564
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEIST---LAVYRLPHPGW 530
+ EML+K+++LGL+ Y N FD G+ +L+ LE+ + ++V+R
Sbjct 565 FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRC----- 619
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
V LL ++ +TR L + + +++L ++++ + +L +
Sbjct 620 ----VRLLRIFKVTRHWTSL---------------SNLVASLLNSMKSIASLLLLLFLFI 660
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+F+++G+ LF G +F++ + + FD+F AL+T++ ++
Sbjct 661 IIFSLLGMQLFGGKF-------------------NFDETQTKRSTFDNFPQALLTVFQIL 701
Query 651 VVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILEN 696
+W V D Y GP S IYF++ ++ + I +N+FLA+ ++N
Sbjct 702 TGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDN 753
Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 122/645 (19%), Positives = 253/645 (39%), Gaps = 85/645 (13%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 877 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGY---FDYAFTAIFTVEIL 933
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 934 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 993
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG---KQDDGQDRERLT 253
+ +K ++C+ ++ + ++ ++ + +F G+ LF G D+ +
Sbjct 994 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSN---- 1049
Query 254 YFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
PE L +L DV P + F V+ ++ M L T +
Sbjct 1050 -----PEECRGLFILYKDG---DVDSPVVRERIWQNSDFNFDNVLSAM--MALFTVSTFE 1099
Query 314 QFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDS 373
+ L K++ ++ G A V + V F + + ++ + + +
Sbjct 1100 GWPALLYKAIDSN------GENAG-PVYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVT 1152
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+Q E Y + L + Q + L ++ + P+ YQ F ++
Sbjct 1153 FQEQGEKE----YKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW----YVVNSSP 1204
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F+Y+ ++ + N + + + + + D ILN VF + +EM+LKV A
Sbjct 1205 FEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMD-----ILNMVFTGVFTVEMVLKVIAFKP 1259
Query 494 RGYLSYPSNVFDGLLTVVLLV----LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
+GY S N FD L+ + ++ E LP P P + +T +
Sbjct 1260 KGYFSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATPGNSEESNRISIT-FFRL 1318
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
V R ++++ + + + T + Q + ++ ++++++A+IG+ +F V +
Sbjct 1319 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAM--- 1375
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------D 660
NNF F A++ L+ WQ + D
Sbjct 1376 ---------------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCD 1420
Query 661 AYRRYS--------GPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y+ ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1421 PDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1465
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 70/309 (23%), Positives = 125/309 (40%), Gaps = 43/309 (14%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L AN V++ +++ D + + L + F++ + +E LK+ A GL
Sbjct 127 FDIFILLAIFANCVALAIYIPFPED--DSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGL 184
Query 494 ----RGYLSYPSNVFDGLLTVVLL---VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
Y+ N+ D ++ +V L +LE T H G +D+ +
Sbjct 185 LLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSS------GKSGGFDV-KA 237
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI- 605
L V R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G +
Sbjct 238 LRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMH 297
Query 606 -VALPGNSSLAPANGSAPCG-----------SFEQLEYWA------NNFDDFAAALVTLW 647
+S + APC E W NFD+FA A++T++
Sbjct 298 KTCFFADSDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPNGGITNFDNFAFAMLTVF 357
Query 648 NLMVVNNWQVFL---DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF---LHKW 701
+ + W L + + PW +YFV + S +NL L ++ F K
Sbjct 358 QCITMEGWTDVLYWMNDAMGFELPW--VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKA 415
Query 702 DPRSHLQPL 710
R Q L
Sbjct 416 KARGDFQKL 424
Score = 48.1 bits (113), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 132/596 (22%), Positives = 239/596 (40%), Gaps = 99/596 (17%)
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL-----RIR 187
L +F ++ VK Y G + +L+ + +V + T+ + L PL R
Sbjct 562 LALFTCEMLVKMYSLGLQAYFVSLFNR-FDCFVVCGGITETILVELELMSPLGVSVFRCV 620
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
RLLR F + ++ + + + + S+ +AS+ LLL + + +F++ GM LF GGK + +
Sbjct 621 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDE 679
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAY----SKNRAYAIFFIVFTVIGS 300
+ + + F N P++L ++ +LT + VM I AY S I+FI+ + G+
Sbjct 680 TQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGN 739
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTS-LFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
L+N+ AI +SL T+ R S+ + P+ +
Sbjct 740 YILLNVFLAIAVDNLAD--AESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIAN 797
Query 360 QNLLQVLQKVQLDSSHKQ--------AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
+ + Q ++ K E+ + A + +EL+ +KE
Sbjct 798 SDNKVTIDDYQEETEDKDPYPPCDVPVGEEEEEEEEEPEVPAGPRPRRISELN---MKEK 854
Query 412 -PPRPEYQSPFLQS--------AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
P PE + F+ S L H+ F L I VF++L + L A
Sbjct 855 IVPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNL-----------ILVFIMLSSAALAA 903
Query 463 ER-------DDFILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPSNVFDGLLTVVL 512
E + ILG + F + +E+LLK+ G +G ++ N F+ LL +++
Sbjct 904 EDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKG--AFCRNYFN-LLDMLV 960
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
+ + + + + S + ++L +L V R LR I K + V V
Sbjct 961 VGVSLVSFGIQS--------------SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCV 1006
Query 573 LGLVQNMRAFGGILVV---VYYVFAIIGINLFRGVIVALPGNSSLAP----------ANG 619
+ R G I++V + ++FA IG+ LF+G + P +G
Sbjct 1007 FVAI---RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDG 1063
Query 620 SAPCGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
+ W N NFD+ +A++ L+ + W L D+ +GP
Sbjct 1064 DVDSPVVRE-RIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENAGP 1118
>sp|P08104|SCN3A_RAT Sodium channel protein type 3 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn3a PE=1 SV=1
Length=1951
Score = 57.0 bits (136), Expect = 8e-07, Method: Compositional matrix adjust.
Identities = 58/241 (24%), Positives = 102/241 (42%), Gaps = 33/241 (14%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV ++ Y
Sbjct 1197 VFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGY----------- 1245
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1246 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1301
Query 595 IIGINLFRG----VIVALPGNS-SLAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTL 646
I+G+NLF G + GN + N + C + + W N NFD+ A + L
Sbjct 1302 IMGVNLFAGKFYHCVNTTTGNMFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLAL 1361
Query 647 WNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILEN 696
+ W + D+ P + +YFV++ + S +NLF+ +I++N
Sbjct 1362 LQVATFKGWMDIMYAAVDSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1421
Query 697 F 697
F
Sbjct 1422 F 1422
Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 129/607 (21%), Positives = 244/607 (40%), Gaps = 126/607 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V VSLV + S L + LR R L
Sbjct 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1310
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + ++ + N D A K + + F +G+ +L L A
Sbjct 1311 --KFYHCVNTTTGNMFEIKEVNNFSDCQ--ALGKQARWKNVKVNFDNVGAGYLALLQVA- 1365
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQN 361
F+G+ M + ++ R + + +E V+ + G +GV N
Sbjct 1366 ---TFKGW-MDIMYAAVDSRDVKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1421
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQ 418
Q +K + G + EE +K +N + + S + P PRP +
Sbjct 1422 FNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1465
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGIL 472
F FD++ + +SI + + L+ + E DD +L +
Sbjct 1466 ----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQSKYMTLVLSRI 1512
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-R 531
N VFIV + E LLK+ +L Y + N+FD V+++L I + + L +
Sbjct 1513 NLVFIVLFTGEFLLKLISLRYY-YFTIGWNIFD----FVVVILSIVGMFLAELIEKYFVS 1567
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V +
Sbjct 1568 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMF 1618
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
++AI G++ F V G + NF+ F +++ L+ +
Sbjct 1619 IYAIFGMSNFAYV---------------KKEAGIDDMF-----NFETFGNSMICLFQITT 1658
Query 652 VNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFL 690
W L D P S + +FV + ++S ++ VN+++
Sbjct 1659 SAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1718
Query 691 ALILENF 697
A+ILENF
Sbjct 1719 AVILENF 1725
Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust.
Identities = 32/134 (24%), Positives = 64/134 (48%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + N VF + EM+LK+ A+ Y N+FDG++ V L ++E+ V L
Sbjct 742 VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII-VSLSLMELGLANVEGL-- 798
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ R +L VF+ + P++ ++ + +G + N+ +L
Sbjct 799 --------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 841
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 842 IIVFIFAVVGMQLF 855
Score = 37.0 bits (84), Expect = 0.95, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 56/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GN S A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 336 LCGNGSDA---GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT 392
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S VNL LA++ ++ ++ L+ A EA +Q +
Sbjct 393 LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQML 449
Query 723 ELL 725
E L
Sbjct 450 EQL 452
>sp|Q9NY46|SCN3A_HUMAN Sodium channel protein type 3 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN3A PE=1 SV=2
Length=2000
Score = 56.6 bits (135), Expect = 9e-07, Method: Compositional matrix adjust.
Identities = 58/241 (24%), Positives = 103/241 (43%), Gaps = 33/241 (14%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV ++ Y
Sbjct 1246 VFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGY----------- 1294
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1295 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1350
Query 595 IIGINLFRG----VIVALPGNS-SLAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTL 646
I+G+NLF G + GN ++ N + C + + W N NFD+ A + L
Sbjct 1351 IMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLAL 1410
Query 647 WNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILEN 696
+ W + D+ P + +YFV++ + S +NLF+ +I++N
Sbjct 1411 LQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1470
Query 697 F 697
F
Sbjct 1471 F 1471
Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 130/608 (21%), Positives = 244/608 (40%), Gaps = 128/608 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V VSLV + S L + LR R L
Sbjct 1250 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1360
Query 251 RLTYFQNLPESLTSLLVLLTTANN-PDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
F + T + ++ NN D A K + + F +G+ +L L A
Sbjct 1361 ----FYHCVNMTTGNMFDISDVNNLSDCQ--ALGKQARWKNVKVNFDNVGAGYLALLQVA 1414
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQ 360
F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1415 T----FKGW-MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIID 1469
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEY 417
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1470 NFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPAN 1513
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGI 471
+ F FD++ + +SI + + L+ + E DD +L
Sbjct 1514 K----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQGKYMTLVLSR 1560
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW- 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + + +
Sbjct 1561 INLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFD----FVVVILSIVGMFLAEMIEKYFV 1615
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1616 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVM 1666
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
+++AI G++ F V G + NF+ F +++ L+ +
Sbjct 1667 FIYAIFGMSNFAYV---------------KKEAGIDDMF-----NFETFGNSMICLFQIT 1706
Query 651 VVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLF 689
W L D P S + +FV + ++S ++ VN++
Sbjct 1707 TSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMY 1766
Query 690 LALILENF 697
+A+ILENF
Sbjct 1767 IAVILENF 1774
Score = 37.0 bits (84), Expect = 0.97, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 56/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GN S A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 336 LCGNGSDA---GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT 392
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S VNL LA++ ++ ++ L+ A EA +Q +
Sbjct 393 LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQML 449
Query 723 ELL 725
E L
Sbjct 450 EQL 452
>sp|P04774|SCN1A_RAT Sodium channel protein type 1 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn1a PE=1 SV=1
Length=2009
Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 126/609 (21%), Positives = 240/609 (39%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1262 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1321
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1322 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1372
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + + T +T NN + +N + + F +G +L L
Sbjct 1373 ----FYHCVNTTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQV 1428
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
A F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1429 AT----FKGW-MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVII 1483
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1484 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPG 1527
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1528 NK----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQSDYVTSILS 1574
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1575 RINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1629
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1630 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1680
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1681 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1720
Query 650 MVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNL 688
W L D P S + +FV + ++S ++ VN+
Sbjct 1721 TTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1780
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1781 YIAVILENF 1789
Score = 50.4 bits (119), Expect = 7e-05, Method: Compositional matrix adjust.
Identities = 56/244 (23%), Positives = 100/244 (41%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV + Y
Sbjct 1258 VFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGY----------- 1306
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1307 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1362
Query 595 IIGINLFRG----VIVALPGNS-SLAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G + G++ + N + C + W N NFD+
Sbjct 1363 IMGVNLFAGKFYHCVNTTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGY 1422
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1423 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
Query 694 LENF 697
++NF
Sbjct 1483 IDNF 1486
Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 33/140 (24%), Positives = 64/140 (46%), Gaps = 20/140 (14%)
Query 462 AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
E + +L + N VF + EM LK+ A+ Y N+FDG + V L ++E+
Sbjct 793 TEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI-VTLSLVELGLAN 851
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
V L + R +L VF+ + P++ ++ + +G + N+
Sbjct 852 VEGL----------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 895
Query 582 FGGILVVVYYVFAIIGINLF 601
+L ++ ++FA++G+ LF
Sbjct 896 ---VLAIIVFIFAVVGMQLF 912
Score = 38.5 bits (88), Expect = 0.34, Method: Compositional matrix adjust.
Identities = 39/130 (30%), Positives = 61/130 (47%), Gaps = 12/130 (9%)
Query 602 RGVIVAL-PGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
GV+ AL GNSS A G P G + Y +FD F+ A ++L+ LM + W
Sbjct 328 EGVLDALLCGNSSDA---GQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFW 384
Query 656 QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE 715
+ R +G I+FVL + S +NL LA++ ++ ++ L+ A E
Sbjct 385 ENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKE 441
Query 716 ATYQMTVELL 725
A +Q +E L
Sbjct 442 AEFQQMLEQL 451
>sp|A2ASI5|SCN3A_MOUSE Sodium channel protein type 3 subunit alpha
OS=Mus musculus OX=10090 GN=Scn3a PE=1 SV=1
Length=1947
Score = 56.2 bits (134), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 130/607 (21%), Positives = 244/607 (40%), Gaps = 126/607 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V VSLV + S L + LR R L
Sbjct 1202 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1261
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1262 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1311
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + S+ + N D A K + + F +G+ +L L A
Sbjct 1312 --KFYHCVNMTTGSMFDMSEVNNFSDCQ--ALGKQARWKNVKVNFDNVGAGYLALLQVA- 1366
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQN 361
F+G+ M + ++ R + + +E V+ + G +GV N
Sbjct 1367 ---TFKGW-MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1422
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQ 418
Q +K + G + EE +K +N + + S + P PRP +
Sbjct 1423 FNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1466
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGIL 472
F FD++ + +SI + + L+ + E DD +L +
Sbjct 1467 ----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQSKYMTLVLSRI 1513
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-R 531
N VFIV + E LLK+ +L Y + N+FD V+++L I + + L +
Sbjct 1514 NLVFIVLFTGEFLLKLISLRYY-YFTIGWNIFD----FVVVILSIVGMFLAELIEKYFVS 1568
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V +
Sbjct 1569 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMF 1619
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
++AI G++ F V G + NF+ F +++ L+ +
Sbjct 1620 IYAIFGMSNFAYV---------------KKEAGIDDMF-----NFETFGNSMICLFQITT 1659
Query 652 VNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFL 690
W L D P S + +FV + ++S ++ VN+++
Sbjct 1660 SAGWDGLLAPILNSAPPDCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1719
Query 691 ALILENF 697
A+ILENF
Sbjct 1720 AVILENF 1726
Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 57/241 (24%), Positives = 102/241 (42%), Gaps = 33/241 (14%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV ++ Y
Sbjct 1198 VFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGY----------- 1246
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1247 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1302
Query 595 IIGINLFRG-----VIVALPGNSSLAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTL 646
I+G+NLF G V + ++ N + C + + W N NFD+ A + L
Sbjct 1303 IMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLAL 1362
Query 647 WNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILEN 696
+ W + D+ P + +YFV++ + S +NLF+ +I++N
Sbjct 1363 LQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDN 1422
Query 697 F 697
F
Sbjct 1423 F 1423
Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust.
Identities = 32/134 (24%), Positives = 64/134 (48%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + N VF + EM+LK+ A+ Y N+FDG++ V L ++E+ V L
Sbjct 742 VLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGII-VSLSLMELGLANVEGL-- 798
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ R +L VF+ + P++ ++ + +G + N+ +L
Sbjct 799 --------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 841
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 842 IIVFIFAVVGMQLF 855
Score = 37.0 bits (84), Expect = 0.98, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 56/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GN S A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 336 LCGNGSDA---GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLT 392
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S VNL LA++ ++ ++ L+ A EA +Q +
Sbjct 393 LRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQML 449
Query 723 ELL 725
E L
Sbjct 450 EQL 452
>sp|A2APX8|SCN1A_MOUSE Sodium channel protein type 1 subunit alpha
OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1
Length=2009
Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 125/609 (21%), Positives = 241/609 (40%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1262 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1321
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1322 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1372
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + + T + ++ NN + +N + + F +G +L L
Sbjct 1373 ----FYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQV 1428
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
A F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1429 AT----FKGW-MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVII 1483
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1484 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPG 1527
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1528 NK----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQSDYVTSILS 1574
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1575 RINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1629
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1630 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1680
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1681 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1720
Query 650 MVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNL 688
W L D P S + +FV + ++S ++ VN+
Sbjct 1721 TTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1780
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1781 YIAVILENF 1789
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 55/244 (23%), Positives = 99/244 (41%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV + Y
Sbjct 1258 VFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGY----------- 1306
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1307 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1362
Query 595 IIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G ++ ++ N + C + W N NFD+
Sbjct 1363 IMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGY 1422
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1423 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
Query 694 LENF 697
++NF
Sbjct 1483 IDNF 1486
Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 33/140 (24%), Positives = 64/140 (46%), Gaps = 20/140 (14%)
Query 462 AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
E + +L + N VF + EM LK+ A+ Y N+FDG + V L ++E+
Sbjct 793 TEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI-VTLSLVELGLAN 851
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
V L + R +L VF+ + P++ ++ + +G + N+
Sbjct 852 VEGL----------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 895
Query 582 FGGILVVVYYVFAIIGINLF 601
+L ++ ++FA++G+ LF
Sbjct 896 ---VLAIIVFIFAVVGMQLF 912
Score = 38.5 bits (88), Expect = 0.34, Method: Compositional matrix adjust.
Identities = 39/130 (30%), Positives = 61/130 (47%), Gaps = 12/130 (9%)
Query 602 RGVIVAL-PGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
GV+ AL GNSS A G P G + Y +FD F+ A ++L+ LM + W
Sbjct 328 EGVLDALLCGNSSDA---GQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFW 384
Query 656 QVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE 715
+ R +G I+FVL + S +NL LA++ ++ ++ L+ A E
Sbjct 385 ENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKE 441
Query 716 ATYQMTVELL 725
A +Q +E L
Sbjct 442 AEFQQMLEQL 451
>sp|Q9ER60|SCN4A_MOUSE Sodium channel protein type 4 subunit alpha
OS=Mus musculus OX=10090 GN=Scn4a PE=1 SV=1
Length=1841
Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 125/603 (21%), Positives = 241/603 (40%), Gaps = 116/603 (19%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLV-DWTVSLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V +SLV +W L + LR R L
Sbjct 1069 IFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRAL 1128
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1129 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1178
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + + + N + Y+ + + + +G + L+ +
Sbjct 1179 --KFYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVG----LGYLSLL 1232
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
+ F+G+ M + ++ R + +EV M + G F L
Sbjct 1233 QVATFKGW-MDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFF----------TL 1281
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K P P Q+
Sbjct 1282 NLFIGVIIDNFNQQ----KKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1337
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGILNCVF 476
FD +SI + + L+ + E DD IL +N VF
Sbjct 1338 GMVYDFVTKQVFD-----------ISIMILICLNMVTMMVETDDQSQLKVDILYNINMVF 1386
Query 477 IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMV 535
I+ + E +LK+FAL Y + N+FD V+++L I LA+ L + P +
Sbjct 1387 IIVFTGECVLKMFAL-RHYYFTIGWNIFD----FVVVILSIVGLALSDLIQKYFVSPTLF 1441
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
++ L + R+L ++ + +R + +M++ A +GL +L +V ++++I
Sbjct 1442 RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYSI 1492
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
G++ F V G + NF+ F +++ L+ + W
Sbjct 1493 FGMSNFAYV---------------KKESGIDDMF-----NFETFGNSIICLFEITTSAGW 1532
Query 656 QVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALIL 694
L D P + I +F + ++S +I VN+++A+IL
Sbjct 1533 DGLLNPILNSGPPDCDPTLENPGTNIKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIIL 1592
Query 695 ENF 697
ENF
Sbjct 1593 ENF 1595
Score = 53.9 bits (128), Expect = 6e-06, Method: Compositional matrix adjust.
Identities = 56/250 (22%), Positives = 106/250 (42%), Gaps = 35/250 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEMLLK A G + Y + D L+ V ++ ++ Y
Sbjct 1058 ILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELG 1117
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P + L L R LR + + M VV + +LG + ++ + +
Sbjct 1118 P---------------IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1162
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGS--FEQLEYWAN---NFD 637
+ + +F+I+G+NLF G ++ ++ N + C S + W N N+D
Sbjct 1163 IFWLIFSIMGVNLFAGKFYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYD 1222
Query 638 DFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVN 687
+ ++L + W + D+ + P + +YFV++ + S +N
Sbjct 1223 NVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLN 1282
Query 688 LFLALILENF 697
LF+ +I++NF
Sbjct 1283 LFIGVIIDNF 1292
Score = 50.1 bits (118), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 51/220 (23%), Positives = 100/220 (45%), Gaps = 34/220 (15%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNL-WLLGYLVVLVVSLVDWTVS-------LSL 178
++ ++ ++VF + +K +F H+ + W + VV+++S+V +S +S
Sbjct 1381 NINMVFIIVFTGECVLK--MFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSP 1438
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++++FGM F
Sbjct 1439 TLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF 1498
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA---------------------NNPDV 277
A K++ G D + F+ S+ L + T+A NP
Sbjct 1499 AYVKKESGID--DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGT 1556
Query 278 MIPAYSKNRAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
I N + I FF + +I L ++N+ AII F
Sbjct 1557 NIKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFN 1596
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 33/140 (24%), Positives = 64/140 (46%), Gaps = 20/140 (14%)
Query 462 AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
E D +L + N VF + EM+LK+ A+ Y N+FD + V L ++E+
Sbjct 597 TEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFI-VTLSLVELGLAN 655
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
V L + R +L VF+ + P++ ++ + +G + N+
Sbjct 656 VQGL----------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 699
Query 582 FGGILVVVYYVFAIIGINLF 601
+L ++ ++FA++G+ LF
Sbjct 700 ---VLAIIVFIFAVVGMQLF 716
Score = 33.9 bits (76), Expect = 7.1, Method: Compositional matrix adjust.
Identities = 28/92 (30%), Positives = 45/92 (49%), Gaps = 10/92 (11%)
Query 608 LPGNSSLAPANGSAPCGSFEQLE------YWANNFDDFAAALVTLWNLMVVNNWQVFLDA 661
L GNSS A G P G +E ++ Y ++D F+ A + L+ LM + W+
Sbjct 353 LCGNSSDA---GHCPEG-YECMKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQL 408
Query 662 YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G I+FV+ + S +NL LA++
Sbjct 409 TLRAAGKTYMIFFVVIIFLGSFYLINLILAVV 440
>sp|Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN9A PE=1 SV=3
Length=1988
Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust.
Identities = 62/251 (25%), Positives = 107/251 (43%), Gaps = 36/251 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + +F ++LEMLLK A G + Y + D L+ V LV TL L +
Sbjct 1225 ILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGY 1280
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P + L L R LR + + M VV + ++G + ++ + +
Sbjct 1281 SDLGP-----------IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCL 1329
Query 588 VVYYVFAIIGINLFRGVIVAL--PGNSSLAPAN---GSAPCGSF---EQLEYWAN---NF 636
+ + +F+I+G+NLF G + S PA+ + C + Q W N NF
Sbjct 1330 IFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNF 1389
Query 637 DDFAAALVTLWNLMVVNNWQVFL---------DAYRRYS-GPWSKIYFVLWWLVSSVIWV 686
D+ ++L + W + + D +Y + IYFV++ + S +
Sbjct 1390 DNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTL 1449
Query 687 NLFLALILENF 697
NLF+ +I++NF
Sbjct 1450 NLFIGVIIDNF 1460
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 49/217 (23%), Positives = 102/217 (47%), Gaps = 32/217 (15%)
Query 128 VEVLCLLVFAAD-----LSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
+ V+ +++F + +S++ Y F GW F + ++ + + + L++ T +S
Sbjct 1550 INVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIE-TYFVSPTL 1608
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++ +FGM FA
Sbjct 1609 FRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1668
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN----------------NPDVMIPAYS- 283
K++DG + + F+ S+ L + T+A +P + P S
Sbjct 1669 VKKEDGIN--DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSV 1726
Query 284 ----KNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQF 315
N + IF F+ + +I L ++N+ A+I F
Sbjct 1727 EGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1763
Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust.
Identities = 43/174 (25%), Positives = 83/174 (48%), Gaps = 28/174 (16%)
Query 433 YFDYLGNLIALANLVSICV-----FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
YF + + LA ++IC+ F+ ++ + E + +L I N VF + EM+LK
Sbjct 738 YFIVMDPFVDLA--ITICIVLNTLFMAMEHHPMTEEFKN-VLAIGNLVFTGIFAAEMVLK 794
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ A+ Y N+FD L I TL++ L + ++ GL L R
Sbjct 795 LIAMDPYEYFQVGWNIFDSL---------IVTLSLVEL----FLADVEGLSVL----RSF 837
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+L VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 838 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 888
Score = 44.3 bits (103), Expect = 0.005, Method: Compositional matrix adjust.
Identities = 65/274 (24%), Positives = 108/274 (39%), Gaps = 48/274 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V V+LV T+ S L + LR R L
Sbjct 1236 IFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1295
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-----KQDD 245
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG D
Sbjct 1296 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTD 1355
Query 246 GQ--------DRERLTYFQNLPESLT----------------SLLVLLTTANNPDVMI-- 279
G +R N+ +++ SLL + T +M
Sbjct 1356 GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAA 1415
Query 280 ---------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
P Y + I+F+VF + GS F +NL +I F K +F
Sbjct 1416 VDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM- 1474
Query 331 RLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
T + ++M G PQ +P N +Q
Sbjct 1475 ---TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ 1505
Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust.
Identities = 56/302 (19%), Positives = 119/302 (39%), Gaps = 72/302 (24%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L +++ + +++ C+F+ ++ P + + ++ L+++L + F +G +
Sbjct 127 LFSMLIMCTILTNCIFMTMNN---PPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTF 183
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L P N D ++ V + E L ++ L FR L
Sbjct 184 LRDPWNWLDFVVIVFAYLTEFVNLG------------------------NVSALRTFRVL 219
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRGVIV------A 607
R + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF G + +
Sbjct 220 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNS 279
Query 608 LPGNSSL-------------------------------APANGSAPCGSF-----EQLEY 631
L N +L + +G P G +Y
Sbjct 280 LENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
+FD F+ A + L+ LM + W+ R +G I+FV+ + S +NL LA
Sbjct 340 GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
Query 692 LI 693
++
Sbjct 400 VV 401
Score = 41.2 bits (95), Expect = 0.050, Method: Compositional matrix adjust.
Identities = 72/349 (21%), Positives = 143/349 (41%), Gaps = 80/349 (23%)
Query 381 EKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQSPFLQSAQF-LFGHYYFDY 436
+K + G + EE +K +N + + S + P PRP + +Q F L + FD
Sbjct 1463 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNK---IQGCIFDLVTNQAFD- 1518
Query 437 LGNLIALANLVSICVFLVLDADVLPAERD------DFILGILNCVFIVYYLLEMLLKVFA 490
+SI V + L+ + E++ +L +N VFI+ + E +LK+ +
Sbjct 1519 ----------ISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLIS 1568
Query 491 LGLRGYLSYPSNVFDGLLTVVLLV-LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
L Y + N+FD ++ ++ +V + ++ L P + R++ +
Sbjct 1569 LR-HYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPT-------------LFRVIRL 1614
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ R LR++ K + + ++ + + G +L +V +++AI G++ F V
Sbjct 1615 ARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDG 1674
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------D 660
N NF+ F +++ L+ + W L D
Sbjct 1675 INDMF--------------------NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD 1714
Query 661 AYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
+ P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1715 CDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1763
>sp|P15390|SCN4A_RAT Sodium channel protein type 4 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn4a PE=1 SV=1
Length=1840
Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust.
Identities = 127/603 (21%), Positives = 244/603 (40%), Gaps = 116/603 (19%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLV-DWTVSLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V +SLV +W L + LR R L
Sbjct 1068 IFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRAL 1127
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1128 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1177
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ Y N S + ++ + + ++ Y+ + + + +G + L+ +
Sbjct 1178 KFYYCVNTTTSERFDISVVNNKSESESLM--YTGQVRWMNVKVNYDNVG----LGYLSLL 1231
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNLL 363
+ F+G+ M + ++ R + +EV M + G F L
Sbjct 1232 QVATFKGW-MDIMYAAVDSREKEEQPHYEVNLYMYLYFVIFIIFGSFF----------TL 1280
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K P P Q+
Sbjct 1281 NLFIGVIIDNFNQQ----KKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1336
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGILNCVF 476
FD +SI + + L+ + E DD IL +N VF
Sbjct 1337 GMVYDFVTKQVFD-----------ISIMILICLNMVTMMVETDDQSQLKVDILYNINMVF 1385
Query 477 IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMV 535
I+ + E +LK+FAL Y + N+FD V+++L I LA+ L + P +
Sbjct 1386 IIIFTGECVLKMFAL-RHYYFTIGWNIFD----FVVVILSIVGLALSDLIQKYFVSPTLF 1440
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
++ L + R+L ++ + +R + +M++ A +GL +L +V ++++I
Sbjct 1441 RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYSI 1491
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
G++ F V S F NF+ F +++ L+ + W
Sbjct 1492 FGMSNFAYV------------KKESGIDDMF--------NFETFGNSIICLFEITTSAGW 1531
Query 656 QVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALIL 694
L D P + + +F + ++S +I VN+++A+IL
Sbjct 1532 DGLLNPILNSGPPDCDPTLENPGTNVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIIL 1591
Query 695 ENF 697
ENF
Sbjct 1592 ENF 1594
Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 56/250 (22%), Positives = 104/250 (42%), Gaps = 35/250 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF ++LEMLLK A G + Y + D L+ V ++ ++ Y
Sbjct 1057 ILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELG 1116
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P + L L R LR + + M VV + +LG + ++ + +
Sbjct 1117 P---------------IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1161
Query 588 VVYYVFAIIGINLFRG-----VIVALPGNSSLAPANGSAPCGS--FEQLEYWAN---NFD 637
+ + +F+I+G+NLF G V ++ N + S + W N N+D
Sbjct 1162 IFWLIFSIMGVNLFAGKFYYCVNTTTSERFDISVVNNKSESESLMYTGQVRWMNVKVNYD 1221
Query 638 DFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKI------YFVLWWLVSSVIWVN 687
+ ++L + W + D+ + P ++ YFV++ + S +N
Sbjct 1222 NVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPHYEVNLYMYLYFVIFIIFGSFFTLN 1281
Query 688 LFLALILENF 697
LF+ +I++NF
Sbjct 1282 LFIGVIIDNF 1291
Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 49/220 (22%), Positives = 100/220 (45%), Gaps = 34/220 (15%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNL-WLLGYLVVLVVSLVDWTVS-------LSL 178
++ ++ +++F + +K +F H+ + W + VV+++S+V +S +S
Sbjct 1380 NINMVFIIIFTGECVLK--MFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQKYFVSP 1437
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++++FGM F
Sbjct 1438 TLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF 1497
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA---------------------NNPDV 277
A K++ G D + F+ S+ L + T+A NP
Sbjct 1498 AYVKKESGID--DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGT 1555
Query 278 MIPAYSKNRAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ N + I FF + +I L ++N+ AII F
Sbjct 1556 NVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFN 1595
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 66/330 (20%), Positives = 134/330 (41%), Gaps = 42/330 (13%)
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
+ Y IFF+V +GS +L+NL+ A++ + + + +L + ++L
Sbjct 415 KTYMIFFVVIIFLGSFYLINLILAVVAMAY----AEQNEATLAEDQEKEEEFQQMLEKYK 470
Query 346 GEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSV-----LLSAEE-FQKL 399
+A K L+ ++ D +H + + + G SA+
Sbjct 471 KHQEELEKA---KAAQALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDA 527
Query 400 FNELDRSVVKEHPP---RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANL-VSICVFL-- 453
EL+ + K PP + ++ + YL + +L ++IC+ L
Sbjct 528 MEELEEAHQK-CPPWWYKCAHKVLIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNT 586
Query 454 -VLDADVLP-AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
+ + P E D +L + N VF + EM+LK+ A+ Y N+FD + V
Sbjct 587 LFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFI-VT 645
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
L ++E+ V L + R +L VF+ + P++ ++ +
Sbjct 646 LSLVELGLANVQGL----------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 689
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+G + N+ +L ++ ++FA++G+ LF
Sbjct 690 SVGALGNLTL---VLAIIVFIFAVVGMQLF 716
Score = 33.9 bits (76), Expect = 7.8, Method: Compositional matrix adjust.
Identities = 27/91 (30%), Positives = 42/91 (46%), Gaps = 8/91 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y ++D F+ A + L+ LM + W+
Sbjct 353 LCGNSSDA---GHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLT 409
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G I+FV+ + S +NL LA++
Sbjct 410 LRAAGKTYMIFFVVIIFLGSFYLINLILAVV 440
>sp|Q28371|SCN4A_HORSE Sodium channel protein type 4 subunit alpha
OS=Equus caballus OX=9796 GN=SCN4A PE=1 SV=1
Length=1834
Score = 54.7 bits (130), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 126/597 (21%), Positives = 242/597 (41%), Gaps = 104/597 (17%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLV-DWTVSLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V +SLV +W L + LR R L
Sbjct 1072 IFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRAL 1131
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1132 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWVIFSIMGVNLFAA---------- 1181
Query 251 RLTYFQNLPESLTSLLVLLTTANNP-DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
++ YF N + TS ++ NN + ++ + + + +G + L+
Sbjct 1182 KIYYFIN---TTTSERFDISGVNNKSECESLIHTGQVRWLNVKVNYDNVG----LGYLSL 1234
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ + F+G+ M + +++ R + +EV M F N L L V
Sbjct 1235 LQVATFKGW-MDIMYSAVDSREQEEQPQYEVNIYMYLYFVIFIIFGSFFTINSLIRLIIV 1293
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQSPFLQSAQFL 428
+ K+ G + EE +K +N + + K P P Q+
Sbjct 1294 NFNQQKKKLG-------GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDF 1346
Query 429 FGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILGILNCVFIVYYLL 482
FD ++I + + L+ + E DD IL +N VFI+ +
Sbjct 1347 VTKQVFD-----------ITIMILICLNMVTMMVETDDQSQLKVDILYNINMVFIIVFTG 1395
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK+FAL + Y + N+FD V+++L I LA+ L + P + ++ L
Sbjct 1396 ECVLKMFAL-RQNYFTVGWNIFD----FVVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1450
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M++ A +GL +L++V ++++I G++ F
Sbjct 1451 RIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLILVMFIYSIFGMSNF 1501
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V G + NF+ F +++ L+ + W L
Sbjct 1502 AYV---------------KKESGIDDMF-----NFETFGNSIICLFEITTSAGWDGLLNP 1541
Query 660 -------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
D P + + +F + ++S +I VN+++A+ILENF
Sbjct 1542 ILNSGPPDCDPTLENPGTSVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1598
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 58/272 (21%), Positives = 114/272 (42%), Gaps = 49/272 (18%)
Query 78 YSNVCQRTLSFTIFLILFLAFI----ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCL 133
Y V ++ TI +++ L + ET D+ Y ++ ++ +
Sbjct 1344 YDFVTKQVFDITIMILICLNMVTMMVETDDQSQLKVDILY-------------NINMVFI 1390
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLVCHEPLRI 186
+VF + +K + +F W + VV+++S+V +S +S +R+
Sbjct 1391 IVFTGECVLKMFALRQNYFTVG-WNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1449
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+ R L++ + ++ L + SLP + ++GLLL + + ++++FGM FA K++ G
Sbjct 1450 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLILVMFIYSIFGMSNFAYVKKESG 1509
Query 247 QDRERLTYFQNLPESLTSLLVLLTTA---------------------NNPDVMIPAYSKN 285
D + F+ S+ L + T+A NP + N
Sbjct 1510 ID--DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTSVRGDCGN 1567
Query 286 RAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ I FF + +I L ++N+ AII F
Sbjct 1568 PSIGICFFCSYIIISFLIVVNMYIAIILENFN 1599
Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 54/250 (22%), Positives = 102/250 (41%), Gaps = 35/250 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF +++EMLLK A G + Y + D L+ V ++ ++ Y
Sbjct 1061 ILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELG 1120
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P + L L R LR + + M VV + +LG + ++ + +
Sbjct 1121 P---------------IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1165
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFEQLEY--WAN---NFD 637
+ + +F+I+G+NLF I ++ ++ N + C S W N N+D
Sbjct 1166 IFWVIFSIMGVNLFAAKIYYFINTTTSERFDISGVNNKSECESLIHTGQVRWLNVKVNYD 1225
Query 638 DFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKI------YFVLWWLVSSVIWVN 687
+ ++L + W + D+ + P ++ YFV++ + S +N
Sbjct 1226 NVGLGYLSLLQVATFKGWMDIMYSAVDSREQEEQPQYEVNIYMYLYFVIFIIFGSFFTIN 1285
Query 688 LFLALILENF 697
+ LI+ NF
Sbjct 1286 SLIRLIIVNF 1295
>sp|Q14524|SCN5A_HUMAN Sodium channel protein type 5 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN5A PE=1 SV=2
Length=2016
Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 59/246 (24%), Positives = 101/246 (41%), Gaps = 40/246 (16%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV ++ + P
Sbjct 1245 MFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP------ 1298
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1299 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFS 1349
Query 595 IIGINLFRGVI--------VALPGNSSLAPANGSAPCGSFEQLE--YWAN---NFDDFAA 641
I+G+NLF G LP N ++ N + C S YW NFD+ A
Sbjct 1350 IMGVNLFAGKFGRCINQTEGDLPLNYTI--VNNKSQCESLNLTGELYWTKVKVNFDNVGA 1407
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSGPWSK----------IYFVLWWLVSSVIWVNLFLA 691
+ L + W + A G + IYFV++ + S +NLF+
Sbjct 1408 GYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIG 1467
Query 692 LILENF 697
+I++NF
Sbjct 1468 VIIDNF 1473
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 69/325 (21%), Positives = 131/325 (40%), Gaps = 82/325 (25%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++A + H F N++ + +++ CVF+ A P ++ ++
Sbjct 119 PIRRAAVKILVHSLF----NMLIMCTILTNCVFM---AQHDPPPWTKYVEYTFTAIYTFE 171
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
L+++L + F L +L P N D +V+++ + E V L +
Sbjct 172 SLVKILARGFCLHAFTFLRDPWNWLD--FSVIIM---------------AYTTEFVDLGN 214
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAII 596
+ + L FR LR + ++ +++ + + V L+Q+++ ++V+ + VFA+I
Sbjct 215 V-------SALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALI 267
Query 597 GINLFRGVI--------VALPGNSSLAPANG----------SAP--------------CG 624
G+ LF G + AL G + A+G S P CG
Sbjct 268 GLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCG 327
Query 625 SF----------------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP 668
+ E ++ +FD FA A + L+ LM + W+ R +G
Sbjct 328 NSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK 387
Query 669 WSKIYFVLWWLVSSVIWVNLFLALI 693
I+F+L + S VNL LA++
Sbjct 388 IYMIFFMLVIFLGSFYLVNLILAVV 412
Score = 50.4 bits (119), Expect = 7e-05, Method: Compositional matrix adjust.
Identities = 138/699 (20%), Positives = 265/699 (38%), Gaps = 201/699 (29%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLVC 180
L E + + VF ++ +K +G+ + N W L +L+V V VSLV T+ + +
Sbjct 1238 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 1297
Query 181 H-EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1298 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1357
Query 240 GG-----KQDDGQ--------------DRERLT----------YFQNLPESLTSLLVLLT 270
G Q +G + LT F N+ +LL + T
Sbjct 1358 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1417
Query 271 TANNPDVMI-----------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
D+M P + N I+F++F + GS F +NL +I F
Sbjct 1418 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ- 1476
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
+++LG + F M
Sbjct 1477 ---------KKKLGGQDIF----------------------------------------M 1487
Query 380 MEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP--EYQSPFLQSAQFLFG---HYYF 434
E+ + Y + + +KL ++ + + PRP +YQ F+F F
Sbjct 1488 TEEQKKYYNAM------KKLGSKKPQKPI----PRPLNKYQG-------FIFDIVTKQAF 1530
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
D + N+V++ V + D E+ + + I N +F+ + E ++K+ AL
Sbjct 1531 DVTIMFLICLNMVTMMV----ETDDQSPEKINILAKI-NLLFVAIFTGECIVKLAAL-RH 1584
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y + N+FD ++ ++ +V + + + + + P + ++ L + R+L ++ +
Sbjct 1585 YYFTNSWNIFDFVVVILSIVGTVLSDIIQKY---FFSPTLFRVIRLARIGRILRLIRGAK 1641
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
+R + +M++ A +GL +L +V ++++I G+
Sbjct 1642 GIRTLLFALMMSLPALFNIGL---------LLFLVMFIYSIFGM---------------- 1676
Query 615 APANGSAPCGSFEQLEYWAN-----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+F +++ A NF FA +++ L+ + W L P+
Sbjct 1677 ---------ANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPY 1727
Query 670 SK--------------------IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
++F + ++S +I VN+++A+ILENF + + +P
Sbjct 1728 CDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEEST--EP 1785
Query 710 LAG-------------TPEATYQMTVELL--FRDILEEP 733
L+ PEAT + +L F D L EP
Sbjct 1786 LSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEP 1824
>sp|Q9W0Y8|SCN60_DROME Sodium channel protein 60E OS=Drosophila
melanogaster OX=7227 GN=NaCP60E PE=2 SV=6
Length=2844
Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 63/256 (25%), Positives = 113/256 (44%), Gaps = 66/256 (26%)
Query 467 FILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVV----LLVLEISTLA 521
FIL + N F + LE ++K+ +GLR Y + P NVFD LL + +L+ +I
Sbjct 2098 FILEVSNAFFTTVFGLEAIVKI--VGLRYHYFTVPWNVFDFLLVLASIFGILMEDI---- 2151
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
++ L +L ++ VFR RI+ +K + + LV ++ A
Sbjct 2152 ---------------MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPA 2196
Query 582 F---GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
G +L ++ +++AI+G++LF GN L G+ + + NF
Sbjct 2197 LFNIGALLGLITFIYAILGMSLF--------GNVKLQ--------GALDDMV----NFQT 2236
Query 639 FAAALVTLWNLMVVNNWQVFLDA------------YRRYSGPWSK-----IYFVLWWLVS 681
F ++ L+ LM W L++ + +G YF + ++S
Sbjct 2237 FGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIIS 2296
Query 682 SVIWVNLFLALILENF 697
+I +N+++A+ILENF
Sbjct 2297 YMIVINMYIAIILENF 2312
Score = 50.1 bits (118), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 57/247 (23%), Positives = 100/247 (40%), Gaps = 44/247 (18%)
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV----LLVLEISTLAVYRLPH 527
+N F + +++EM+LK ALG Y + + D ++ V LL+ E L V R
Sbjct 1788 INFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLR--- 1844
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
L L R LR I + M +V + ++ + ++ + +
Sbjct 1845 ------------------SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCL 1886
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS----LAPANGSAPCGSFEQLEYWANN---FDDFA 640
V + +F+I+G+ F G + N C EQ W N+ FD
Sbjct 1887 VFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVG 1944
Query 641 AALVTLWNLMVVNNW-QVFLDAY---------RRYSGPWSKIYFVLWWLVSSVIWVNLFL 690
+ L + W +V DA +R + ++ IYFV++ + S +NLF+
Sbjct 1945 MGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFI 2004
Query 691 ALILENF 697
+I++NF
Sbjct 2005 GVIIDNF 2011
Score = 40.0 bits (92), Expect = 0.12, Method: Compositional matrix adjust.
Identities = 56/266 (21%), Positives = 106/266 (40%), Gaps = 42/266 (16%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVS----LVDWTVSLSLVCHEPLRIRRL 189
L+F ++ +K G++ + + W + +++ VS L++ +L ++ LR R
Sbjct 1794 LIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVL--RSLRTLRA 1851
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-------- 241
LRP + M+ + + +++P + +V L+ + +F++ G+ F G
Sbjct 1852 LRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM 1911
Query 242 -------KQDDGQDRERLTY--------FQNLPESLTSLLVLLTTANNPDVMI------- 279
+ +D D Y F ++ +LL + T +VM
Sbjct 1912 GELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
Query 280 ----PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
P N I+F++F V GS F +NL +I F L K + + L T
Sbjct 1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFL-TE 2029
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQN 361
+ ++M G PQ V +P N
Sbjct 2030 SQKHYYTAMKKLGRKKPQKVIKRPIN 2055
Score = 38.1 bits (87), Expect = 0.44, Method: Compositional matrix adjust.
Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 23/150 (15%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
RI R+LR L++ + ++K L + SLP + ++G LL + ++ + GM LF K
Sbjct 2168 FRIGRILR---LIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL 2224
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM-------------IPAYSKNRA--- 287
D + FQ S+ L L+T+A DV+ I ++
Sbjct 2225 QGALD--DMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHP 2282
Query 288 --YAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+F F +I + ++N+ AII F
Sbjct 2283 LLAITYFTSFIIISYMIVINMYIAIILENF 2312
Score = 36.2 bits (82), Expect = 1.6, Method: Compositional matrix adjust.
Identities = 39/195 (20%), Positives = 77/195 (39%), Gaps = 51/195 (26%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP + ++ + +FDY +A ++ C+FL + V AE +F+
Sbjct 113 SPARRVCVYIATNQFFDY----CVMATILFNCIFLAMTETVEEAEY----------IFLA 158
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTV---VLLVLEISTLAVYRLPHPGWR 531
Y +EM++K+ A G YL P N D ++ + +E+ LA R
Sbjct 159 IYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLR------- 211
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
FR LR + ++ +M + + + L+ + R ++ + +
Sbjct 212 --------------------TFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIF 251
Query 592 ---VFAIIGINLFRG 603
VFA+ + ++ G
Sbjct 252 CLMVFALFALQVYMG 266
>sp|Q62968|SCNAA_RAT Sodium channel protein type 10 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn10a PE=1 SV=1
Length=1956
Score = 54.3 bits (129), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 64/261 (25%), Positives = 106/261 (41%), Gaps = 66/261 (25%)
Query 475 VFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
VF V Y E L+K+ A G YL P N D +V L + G
Sbjct 159 VFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLD--------------FSVITLAYVGA 204
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
++ G+ L R +L + + +IP +K++ V L+ ++R + ++
Sbjct 205 AIDLRGISGL----RTFRVLRALKTVSVIPGLKVI------VGALIHSVRKLADVTILTV 254
Query 591 Y---VFAIIGINLFRG-------------------------VIVALPGNSS-LAPANGS- 620
+ VFA++G+ LF+G I PG + L NGS
Sbjct 255 FCLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSD 314
Query 621 ---APCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
P G + + ++ +FD FA A ++L+ LM ++W+ R SG +
Sbjct 315 AGHCPGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMV 374
Query 673 YFVLWWLVSSVIWVNLFLALI 693
+FVL + S VNL LA++
Sbjct 375 FFVLVIFLGSFYLVNLILAVV 395
Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust.
Identities = 124/601 (21%), Positives = 247/601 (41%), Gaps = 107/601 (18%)
Query 134 LVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLSLVCH-EPLRIRRL 189
+F ++ +K +G+ + N W L +L+V + SL+ + S V + LR R
Sbjct 1196 FIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRA 1255
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG K D
Sbjct 1256 LRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG-KFSKCVDT 1314
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
R F N V T NN +++N F++ V M L
Sbjct 1315 -RNNPFSN---------VNSTMVNNKS---ECHNQNSTGHFFWVNVKVNFDNVAMGYLAL 1361
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM-------VGEGGAFPQAVGVKPQNL 362
+ + F+G+ M + ++ + ++ +E M + GG F
Sbjct 1362 LQVATFKGW-MDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFF----------T 1410
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L + V +D+ ++Q K + G + EE +K +N + + K+ P+ P
Sbjct 1411 LNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKK--PQKPIPRPLN 1464
Query 423 QSAQFLFG---HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+ F+F FD + ++ N+++ ++++ D E+ +LG +N F+
Sbjct 1465 KYQGFVFDIVTRQAFDIIIMVLICLNMIT----MMVETDEQGEEKTK-VLGRINQFFVAV 1519
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTL---AVYRLPHPGWRPEMVG 536
+ E ++K+FAL + Y + NVFD ++++L I +L A+ + + P +
Sbjct 1520 FTGECVMKMFAL-RQYYFTNGWNVFD----FIVVILSIGSLLFSAILKSLENYFSPTLFR 1574
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
++ L + R+L ++ + +R + +M++ A +GL +L +V ++++I
Sbjct 1575 VIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYSIF 1625
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G+ F V+ + NF F +++ L+ + W
Sbjct 1626 GMASFANVVDEAGIDDMF--------------------NFKTFGNSMLCLFQITTSAGWD 1665
Query 657 VFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILEN 696
L P+ I+F + ++S +I VN+++A+ILEN
Sbjct 1666 GLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILEN 1725
Query 697 F 697
F
Sbjct 1726 F 1726
Score = 50.1 bits (118), Expect = 8e-05, Method: Compositional matrix adjust.
Identities = 57/252 (23%), Positives = 101/252 (40%), Gaps = 37/252 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + VF ++ EMLLK A G + Y + D L+ + L I+ + Y
Sbjct 1186 VLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEY---- 1241
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
S + L L R LR + + M VV ++G + ++ + +
Sbjct 1242 -----------SDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCL 1290
Query 588 VVYYVFAIIGINLFRGVIVALP-------GNSSLAPANGSAPCGSFEQLE--YWAN---N 635
+ + +F+I+G+NLF G N + N + C + +W N N
Sbjct 1291 IFWLIFSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVN 1350
Query 636 FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP-WSK-----IYFVLWWLVSSVIW 685
FD+ A + L + W + D+ S P W +YFV++ +
Sbjct 1351 FDNVAMGYLALLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFT 1410
Query 686 VNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1411 LNLFVGVIIDNF 1422
Score = 42.0 bits (97), Expect = 0.027, Method: Compositional matrix adjust.
Identities = 35/135 (26%), Positives = 61/135 (45%), Gaps = 20/135 (15%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
D +L N VF V++ +EM K+ A Y N+FD ++ V L LE+S
Sbjct 693 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSL-LELSA------ 745
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
G LS+ R +L VF+ + P++ + + +G + N+ I
Sbjct 746 -------SKKGSLSVL---RTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTF---I 792
Query 586 LVVVYYVFAIIGINL 600
L ++ ++FA++G L
Sbjct 793 LAIIVFIFALVGKQL 807
Score = 33.5 bits (75), Expect = 9.3, Method: Compositional matrix adjust.
Identities = 55/215 (26%), Positives = 101/215 (47%), Gaps = 31/215 (14%)
Query 151 HFQKNLWLLGYLVVLVVSLVDWTVS----LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTL 206
+FQK W + V++ VSL++ + S LS+ LR RLLR F L ++ + +
Sbjct 723 YFQKK-WNIFDCVIVTVSLLELSASKKGSLSV-----LRTFRLLRVFKLAKSWPTLNTLI 776
Query 207 KCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--GKQDDGQ---DRERLTYFQNLPES 261
K I S+ + ++ +LAI + +F + G L + G + DG + E+L + ++ +
Sbjct 777 KIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRKDGVSVWNGEKLRW--HMCDF 834
Query 262 LTSLLVLLTTANNPDV----MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
S LV+ + + S+ I F+ V+G+L ++NL A++ + F
Sbjct 835 FHSFLVVFRILCGEWIENMWVCMEVSQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSA 894
Query 318 YLM---------KSLQTSLFR-RRLGTRAAFEVLS 342
+ +LQ +L R + LG RA+ + S
Sbjct 895 DNLTAPEDDGEVNNLQLALARIQVLGHRASRAIAS 929
>sp|P35499|SCN4A_HUMAN Sodium channel protein type 4 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN4A PE=1 SV=4
Length=1836
Score = 53.9 bits (128), Expect = 5e-06, Method: Compositional matrix adjust.
Identities = 55/250 (22%), Positives = 105/250 (42%), Gaps = 35/250 (14%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF +++EMLLK A G + Y + D L+ V ++ ++ Y
Sbjct 1064 ILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELG 1123
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P + L L R LR + + M VV + +LG + ++ + +
Sbjct 1124 P---------------IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCL 1168
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFEQLEY--WAN---NFD 637
+ + +F+I+G+NLF G ++ ++ N + C S W N N+D
Sbjct 1169 IFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYD 1228
Query 638 DFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKI------YFVLWWLVSSVIWVN 687
+ ++L + W + D+ + P ++ YFV++ + S +N
Sbjct 1229 NVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLN 1288
Query 688 LFLALILENF 697
LF+ +I++NF
Sbjct 1289 LFIGVIIDNF 1298
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 64/273 (23%), Positives = 110/273 (40%), Gaps = 47/273 (17%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLV-DWTVSLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V +SLV +W L + LR R L
Sbjct 1075 IFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRAL 1134
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG---------- 240
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1135 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTT 1194
Query 241 ------GKQDDGQDRERLTY------------FQNLPESLTSLLVLLTTANNPDVMI--- 279
+ ++ + E L + + N+ SLL + T D+M
Sbjct 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAV 1254
Query 280 --------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRR 331
P Y N ++F++F + GS F +NL +I F K +F
Sbjct 1255 DSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFM-- 1312
Query 332 LGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
T + ++M G PQ +PQN +Q
Sbjct 1313 --TEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1343
Score = 47.4 bits (111), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 50/208 (24%), Positives = 91/208 (44%), Gaps = 41/208 (20%)
Query 140 LSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVDWTVS-------LSLVCHEPLRIRRLL 190
L+++ Y F GW F VV+++S+V +S +S +R+ R+
Sbjct 1405 LALRQYYFTVGWNIFD--------FVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIG 1456
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L++ + ++ L + SLP + ++GLLL + + ++++FGM FA K++ G D
Sbjct 1457 RVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGID-- 1514
Query 251 RLTYFQNLPESLTSLLVLLTTA---------------------NNPDVMIPAYSKNRAYA 289
+ F+ S+ L + T+A NP + N +
Sbjct 1515 DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIG 1574
Query 290 I-FFIVFTVIGSLFLMNLLTAIIYSQFR 316
I FF + +I L ++N+ AII F
Sbjct 1575 ICFFCSYIIISFLIVVNMYIAIILENFN 1602
Score = 43.9 bits (102), Expect = 0.007, Method: Compositional matrix adjust.
Identities = 33/140 (24%), Positives = 65/140 (46%), Gaps = 20/140 (14%)
Query 462 AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
E D +L + N VF + EM+LK+ A+ Y N+FD ++ V L ++E+
Sbjct 603 TEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII-VTLSLVELGLAN 661
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
V L + R +L VF+ + P++ ++ + +G + N+
Sbjct 662 VQGL----------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 705
Query 582 FGGILVVVYYVFAIIGINLF 601
+L ++ ++FA++G+ LF
Sbjct 706 ---VLAIIVFIFAVVGMQLF 722
Score = 33.9 bits (76), Expect = 7.7, Method: Compositional matrix adjust.
Identities = 27/91 (30%), Positives = 42/91 (46%), Gaps = 8/91 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y ++D F+ A + L+ LM + W+
Sbjct 359 LCGNSSDA---GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLT 415
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
R +G I+FV+ + S +NL LA++
Sbjct 416 LRAAGKTYMIFFVVIIFLGSFYLINLILAVV 446
>sp|Q62205|SCN9A_MOUSE Sodium channel protein type 9 subunit alpha
OS=Mus musculus OX=10090 GN=Scn9a PE=1 SV=2
Length=1984
Score = 53.9 bits (128), Expect = 7e-06, Method: Compositional matrix adjust.
Identities = 125/600 (21%), Positives = 243/600 (41%), Gaps = 109/600 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V V+LV T+ S L + LR R L
Sbjct 1234 IFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1293
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1294 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1343
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+++ + + S + AN + + S N + + F +G + L+
Sbjct 1344 --KFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVG----LGYLSL 1397
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQ 360
+ + F+G+ M + ++ + + +E V+ + G +GV
Sbjct 1398 LQVATFKGW-MDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1456
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQS 419
N Q QK +L G + EE +K +N + + K P P +
Sbjct 1457 NFNQ--QKKKLG--------------GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1500
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
F L + FD ++ N+V++ V D + F+L +N VFI+
Sbjct 1501 KFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYM-----SFVLYWINVVFIIL 1555
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+ +L Y + N+FD V+++L I + + + + P + ++
Sbjct 1556 FTGECVLKLISL-RHYYFTVGWNIFD----FVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1610
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M++ A +GL +L +V +++AI G+
Sbjct 1611 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYAIFGM 1661
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V N NF+ F +++ L+ + W
Sbjct 1662 SNFAYVKKEAGINDMF--------------------NFETFGNSMICLFQITTSAGWDGL 1701
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D + P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1702 LAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1761
Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust.
Identities = 57/244 (23%), Positives = 103/244 (42%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV TL L + P
Sbjct 1230 IFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGYSDLGP-- 1283
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1284 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1334
Query 595 IIGINLFRGVIVALPGNS-----SLAPANGSAPCGSFEQLE---YWAN---NFDDFAAAL 643
I+G+NLF G + S++ + C + + W N NFD+
Sbjct 1335 IMGVNLFAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGY 1394
Query 644 VTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + D+ + P + IYFV++ + S +NLF+ +I
Sbjct 1395 LSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1454
Query 694 LENF 697
++NF
Sbjct 1455 IDNF 1458
Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 45/175 (26%), Positives = 84/175 (48%), Gaps = 30/175 (17%)
Query 433 YFDYLGNLIALANLVSICVFLVLDADVLPAER----DDF--ILGILNCVFIVYYLLEMLL 486
YF + + LA ++IC+ VL+ + E D+F +L + N VF + EM+L
Sbjct 737 YFIVMDPFVDLA--ITICI--VLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVL 792
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K+ A+ Y N+FD L I TL++ L + ++ GL L R
Sbjct 793 KLIAMDPYEYFQVGWNIFDSL---------IVTLSLVEL----FLADVEGLSVL----RS 835
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+L VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 836 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 887
Score = 42.4 bits (98), Expect = 0.018, Method: Compositional matrix adjust.
Identities = 56/302 (19%), Positives = 117/302 (39%), Gaps = 72/302 (24%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L +++ + +++ C+F+ + P + + ++ L+++L + F +G +
Sbjct 127 LFSMLIMCTILTNCIFMTMSN---PPDWTKNVEYTFTGIYTFESLIKILARGFCVGEFTF 183
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L P N D ++ V + E L ++ L FR L
Sbjct 184 LRDPWNWLDFVVIVFAYLTEFVNLG------------------------NVSALRTFRVL 219
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRGVI------VA 607
R + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF G +
Sbjct 220 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKD 279
Query 608 LPGNSSL-------------------------------APANGSAPCG-----SFEQLEY 631
L N +L + +G P G + +Y
Sbjct 280 LEQNETLESIMSTAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDY 339
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
+FD F A + L+ LM + W+ R +G I+FV+ + S +NL LA
Sbjct 340 GYTSFDTFGWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
Query 692 LI 693
++
Sbjct 400 VV 401
Score = 41.6 bits (96), Expect = 0.034, Method: Compositional matrix adjust.
Identities = 49/218 (22%), Positives = 103/218 (47%), Gaps = 34/218 (16%)
Query 128 VEVLCLLVFAAD-----LSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLV 179
+ V+ +++F + +S++ Y F GW F + +L + + + +++ + VS +L
Sbjct 1548 INVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF 1607
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++ +FGM FA
Sbjct 1608 --RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1665
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN----------------NPDVMIPAYS 283
K++ G + + F+ S+ L + T+A +P + P S
Sbjct 1666 YVKKEAGIN--DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSS 1723
Query 284 -----KNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQF 315
N + IF F+ + +I L ++N+ A+I F
Sbjct 1724 VEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1761
>sp|P27732|CAC1D_RAT Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Rattus norvegicus OX=10116 GN=Cacna1d PE=1
SV=2
Length=2203
Score = 53.5 bits (127), Expect = 7e-06, Method: Compositional matrix adjust.
Identities = 124/646 (19%), Positives = 255/646 (39%), Gaps = 102/646 (16%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 938 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGY---FDYAFTAIFTVEIL 994
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 995 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1054
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF GK D +
Sbjct 1055 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFK-GKFYRCTDEAKSN--- 1110
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F V+ ++ M L T + +
Sbjct 1111 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDFNFDNVLSAM--MALFTVSTFEGWP 1163
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
L K++ ++ G V + V F + + ++ + + + +
Sbjct 1164 ALLYKAIDSN------GENVG-PVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1216
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P+ YQ F ++ F+Y
Sbjct 1217 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFW----YVVNSSPFEY 1268
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + + + D ILN VF + +EM+LKV A +GY
Sbjct 1269 MMFVLIMLNTLCLAMQHYEQSKMFNDAMD-----ILNMVFTGVFTVEMVLKVIAFKPKGY 1323
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV--FR 554
S N FD L+ V+ +++++ LS D + N + + FR
Sbjct 1324 FSDAWNTFDSLI-VIGSIIDVA-------------------LSEADNSEESNRISITFFR 1363
Query 555 FLRIIPSMKLMAVVAS------TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL 608
R++ +KL++ T + Q + ++ ++++++A+IG+ +F V +
Sbjct 1364 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAM-- 1421
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL--------- 659
NNF F A++ L+ WQ +
Sbjct 1422 ----------------RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLC 1465
Query 660 DAYRRYS--------GPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
D Y+ ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1466 DPDSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1511
Score = 53.5 bits (127), Expect = 7e-06, Method: Compositional matrix adjust.
Identities = 57/244 (23%), Positives = 113/244 (46%), Gaps = 58/244 (24%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD------GLLTVVLLVLEIST-- 519
I I N V + + EML+K+++LGL+ Y N FD G+ +L+ LE+ +
Sbjct 613 IQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELELMSPL 672
Query 520 -LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
++V+R V LL ++ +TR L + + +++L +++
Sbjct 673 GVSVFRC---------VRLLRIFKVTRHWTSL---------------SNLVASLLNSMKS 708
Query 579 MRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
+ + +L + +F+++G+ LF G +F++ + + FD+
Sbjct 709 IASLLLLLFLFIIIFSLLGMQLFGGKF-------------------NFDETQTKRSTFDN 749
Query 639 FAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLAL 692
F AL+T++ ++ +W V D Y GP S IYF++ ++ + I + LFLA+
Sbjct 750 FPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAI 809
Query 693 ILEN 696
++N
Sbjct 810 AVDN 813
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 64/287 (22%), Positives = 123/287 (43%), Gaps = 28/287 (10%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD L AN V++ +++ D + + L + F++ + +E LK+ A GL
Sbjct 128 FDIFILLAIFANCVALAIYIPFPED--DSNSTNHNLEKVEYAFLIIFTVETFLKIIASGL 185
Query 494 RGYLSYP-SNVFDG--LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
L +P ++V +G LL V++++ + ++ + +L S + L
Sbjct 186 ---LLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAF 242
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI----- 605
V R LR++ + + VV ++++ + + +++ V ++AIIG+ LF G +
Sbjct 243 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCF 302
Query 606 --------------VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
A GN ANG+ + NFD+FA A++T++ +
Sbjct 303 FADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCIT 362
Query 652 VNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W L G W +YFV ++ S +NL L ++ F
Sbjct 363 MEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEF 409
Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 135/596 (23%), Positives = 229/596 (38%), Gaps = 120/596 (20%)
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL-----RIR 187
L +F ++ VK Y G + +L+ + +V + T+ + L PL R
Sbjct 622 LALFTCEMLVKMYSLGLQAYFVSLFNR-FDCFVVCGGITETILVELELMSPLGVSVFRCV 680
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
RLLR F + ++ + + + + S+ +AS+ LLL + + +F++ GM LF GGK + +
Sbjct 681 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDE 739
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAY----SKNRAYAIFFIVFTVIGS 300
+ + + F N P++L ++ +LT + VM I AY S I+FI+ + G+
Sbjct 740 TQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGN 799
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
L+ L AI +SL T+ A E + + KP+
Sbjct 800 YILLKLFLAIAVDNLAD--AESLNTA------QKEEAEEKERKKIARKESLENKKNNKPE 851
Query 361 --NLLQVLQKVQLDSSHKQAMMEK--------------VRSYGSVLLSAEEFQKLFNELD 404
+ KV +D ++A + + A + +EL+
Sbjct 852 VNQIANSDNKVTIDDYQEEAEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELN 911
Query 405 RSVVKEH-PPRPEYQSPFLQS--------AQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
+KE P PE + F+ S L H+ F L I VF++L
Sbjct 912 ---MKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNL-----------ILVFIML 957
Query 456 DADVLPAER-------DDFILGILNCVFIVYYLLEMLLKVFALG--------LRGYLSYP 500
+ L AE + ILG + F + +E+LLK+ G R Y
Sbjct 958 SSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF--- 1014
Query 501 SNVFDGLLTVVLLV-LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
N+ D L+ V LV I + A+ + ++L +L V R LR I
Sbjct 1015 -NLLDMLVVGVSLVSFGIQSSAI-------------------SVVKILRVLRVLRPLRAI 1054
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIGINLFRGVIVALPGNSSLAP 616
K + V V + R G I++V ++FA IG+ LF+G + P
Sbjct 1055 NRAKGLKHVVQCVFVAI---RTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNP 1111
Query 617 ----------ANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL 659
+G + W N NFD+ +A++ L+ + W L
Sbjct 1112 EECRGLFILYKDGDVDSPVVRE-RIWQNSDFNFDNVLSAMMALFTVSTFEGWPALL 1166
>sp|P35498|SCN1A_HUMAN Sodium channel protein type 1 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN1A PE=1 SV=2
Length=2009
Score = 53.5 bits (127), Expect = 8e-06, Method: Compositional matrix adjust.
Identities = 125/609 (21%), Positives = 239/609 (39%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1262 IFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1321
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1322 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1372
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + + T + NN + +N + + F +G +L L
Sbjct 1373 ----FYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQV 1428
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
A F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1429 AT----FKGW-MDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVII 1483
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1484 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPG 1527
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1528 NK----------FQGMVFDFVTRQVFD---ISIMILICLNMVTMMVETDDQSEYVTTILS 1574
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1575 RINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1629
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1630 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1680
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1681 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1720
Query 650 MVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNL 688
W L D P S + +FV + ++S ++ VN+
Sbjct 1721 TTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1780
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1781 YIAVILENF 1789
Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 61/244 (25%), Positives = 104/244 (43%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV +L L + E+
Sbjct 1258 VFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLV----SLTANALGYS----EL 1309
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ SL R L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1310 GAIKSL----RTLRAL---RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1362
Query 595 IIGINLFRG----VIVALPGNS-SLAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G I G+ + N C + W N NFD+
Sbjct 1363 IMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGY 1422
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1423 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
Query 694 LENF 697
++NF
Sbjct 1483 IDNF 1486
Score = 42.4 bits (98), Expect = 0.019, Method: Compositional matrix adjust.
Identities = 41/171 (24%), Positives = 78/171 (46%), Gaps = 28/171 (16%)
Query 439 NLIALANLV--SICVFLVLDADVLPAER----DDF--ILGILNCVFIVYYLLEMLLKVFA 490
NL+ + V +I + +VL+ + E D F +L + N VF + EM LK+ A
Sbjct 762 NLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIA 821
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
+ Y N+FDG + V L ++E+ V L + R +L
Sbjct 822 MDPYYYFQEGWNIFDGFI-VTLSLVELGLANVEGL----------------SVLRSFRLL 864
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 865 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 912
Score = 38.5 bits (88), Expect = 0.28, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 335 LCGNSSDA---GQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLT 391
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S +NL LA++ ++ ++ L+ A EA +Q +
Sbjct 392 LRAAGKTYMIFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQMI 448
Query 723 ELL 725
E L
Sbjct 449 EQL 451
>sp|Q05973|SCN1_HETBL Sodium channel protein 1 brain OS=Heterololigo
bleekeri OX=1423826 PE=2 SV=1
Length=1522
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 65/287 (23%), Positives = 120/287 (42%), Gaps = 34/287 (12%)
Query 458 DVLPAERDDFILGI--LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVL 515
D+ E+ L I L+ F + + LEM+LK+ ALG Y ++ + D T+V+
Sbjct 803 DIYLNEKPRLKLAIFYLDITFCLLFFLEMVLKLVALGFVHYYTHFWTILD--FTIVI--- 857
Query 516 EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+ V L G E + R L L R LR + + M ++ + ++
Sbjct 858 ----ITVISLAASGLGMEQITAF------RSLRTLRALRPLRAVSRWQGMKIIVNALMLS 907
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL--PGNSSLAPANGSAPCGSFEQLEYWA 633
+ ++ + VV + +FAI+G+ LF G N + P + + + W
Sbjct 908 IPSIFNVLLVCVVFWLIFAIMGVQLFAGKFYKCVNETNMRIPPTEVANKIECYNKNYTWV 967
Query 634 N---NFDDFAAALVTLWNLMVVNNW-QVFLDAY---------RRYSGPWSKIYFVLWWLV 680
N NFD+ A + L+ + W ++ DA + + + YFVL+ +
Sbjct 968 NSNVNFDNVGGAFLALFQVATFEGWMEIMADAVDVTEVDEQPKFEATVYYYFYFVLFIIF 1027
Query 681 SSVIWVNLFLALILE--NFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
S +NL + +I++ +FL K ++L + Y T++ L
Sbjct 1028 GSFFVLNLVIGVIIDKFSFLKKKYDGTYLDMFLTPTQQNYYNTLKKL 1074
Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 55/274 (20%), Positives = 108/274 (39%), Gaps = 41/274 (15%)
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LSLVCHEPLRI 186
CLL F ++ +K G+ H+ + W + +++++++ S + LR
Sbjct 823 FCLLFFL-EMVLKLVALGFVHYYTHFWTILDFTIVIITVISLAASGLGMEQITAFRSLRT 881
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG------ 240
R LRP + MK + + S+P + +V L+ + +F + G+ LFAG
Sbjct 882 LRALRPLRAVSRWQGMKIIVNALMLSIPSIFNVLLVCVVFWLIFAIMGVQLFAGKFYKCV 941
Query 241 ------------GKQDDGQDRERL-----TYFQNLPESLTSLLVLLT-------TANNPD 276
+ + ++ F N+ + +L + T A+ D
Sbjct 942 NETNMRIPPTEVANKIECYNKNYTWVNSNVNFDNVGGAFLALFQVATFEGWMEIMADAVD 1001
Query 277 VM----IPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRL 332
V P + Y +F++F + GS F++NL+ +I +F +L K + L
Sbjct 1002 VTEVDEQPKFEATVYYYFYFVLFIIFGSFFVLNLVIGVIIDKF-SFLKKKYDGTYLDMFL 1060
Query 333 GTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
T +++ G PQ +P+N Q +
Sbjct 1061 -TPTQQNYYNTLKKLGTKKPQKTVKRPKNKCQAV 1093
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 73/343 (21%), Positives = 137/343 (40%), Gaps = 76/343 (22%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P + A + + FDY + N CVFL + D+ +E ++I F+
Sbjct 41 RNPIRRLAVCIATNVCFDYFLMFTIMIN----CVFLAM-PDI--SEFAEYI-------FL 86
Query 478 VYYLLEMLLKVFALGL-RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVG 536
Y +EM +K+ A G +Y + ++ L V+++ I+ L + + ++ G
Sbjct 87 GIYTMEMAIKLVAGGFFIDKYTYLRDAWNCLDFTVIMISYITLL--LQTINDKVISDITG 144
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VF 593
L R +L R L IIP +K M V L++ +R +L+++ + +F
Sbjct 145 L-------RTFRVLRALRTLSIIPGLKTM------VNALLRALRMLISVLILILFCLWIF 191
Query 594 AIIGINLFRGV-----IVALPGNSSLAP-----------------------------ANG 619
+ G+ LF G ++ + G+ + A G
Sbjct 192 SQAGVQLFGGALRHKCVLQIHGSPAFGKTYDEFYAEHIENSDNWLAKGNGEYVLCGNATG 251
Query 620 SAPCGSF--------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
+ PC + E Y NFD +++ + L+ + W+ + R PW+
Sbjct 252 AGPCPTNYTCLPDIGENPNYGYTNFDSIGWSMLISFQLLTQDYWEDVYNKVIRAHSPWTV 311
Query 672 IYFVLWWLVSSVIWVNLFLALILENF-LHKWDPRSHLQPLAGT 713
IYF++ S+ +NL LA++ + L + LQ A T
Sbjct 312 IYFIVINFFGSLYLMNLMLAVVATAYELEVKNTGKKLQQTAAT 354
Score = 36.6 bits (83), Expect = 1.1, Method: Compositional matrix adjust.
Identities = 68/287 (24%), Positives = 111/287 (39%), Gaps = 80/287 (28%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVLLVLE-----ISTLA 521
+L N F + Y +E ++K+ +GLR YL NVFD L V L V++ I
Sbjct 1132 VLATANIAFTILYAVEAIIKI--IGLRIHYLRNLWNVFD-FLVVTLSVMDAFLNDIFGDG 1188
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
++ P SL + RM FR RII +K + + LV ++ A
Sbjct 1189 IFMNP------------SLLRVARM------FRIGRIIRLIKWAKGMRKLLFALVISLPA 1230
Query 582 F---GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
G +L++V +++ IIG++ F + ++ N + NF
Sbjct 1231 LFNIGALLMLVMFIYTIIGMSSFGQIKLSGALNDQV--------------------NFQT 1270
Query 639 FAAALVTLWNLMVVNNWQVFL--------------------DAYRRYSG----PWSKI-Y 673
F + L L W L + + +G PW I Y
Sbjct 1271 FGKTFLLLVRLATSAGWNDILGPLLIQPPNCDPNYITTSTGEKIKVVNGDCGMPWLAISY 1330
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
V + ++ +I N+++A+ILENF ++H Q G E M
Sbjct 1331 MVSYIIIVFMIVFNMYIAVILENF-----NQAHAQEEVGITEDDLDM 1372
Score = 35.4 bits (80), Expect = 2.8, Method: Compositional matrix adjust.
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 10/138 (7%)
Query 151 HFQKNLWLLGYLVVLVVSLVDWTVSLSL---VCHEP--LRIRRLLRP---FFLLQNSSMM 202
H+ +NLW + +V+ +S++D ++ + P LR+ R+ R L++ + M
Sbjct 1158 HYLRNLWNVFDFLVVTLSVMDAFLNDIFGDGIFMNPSLLRVARMFRIGRIIRLIKWAKGM 1217
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESL 262
+K L + SLP + ++G LL + + ++T+ GM F K + + FQ ++
Sbjct 1218 RKLLFALVISLPALFNIGALLMLVMFIYTIIGMSSFGQIKLSGALNDQ--VNFQTFGKTF 1275
Query 263 TSLLVLLTTANNPDVMIP 280
L+ L T+A D++ P
Sbjct 1276 LLLVRLATSAGWNDILGP 1293
>sp|Q28644|SCN9A_RABIT Sodium channel protein type 9 subunit alpha
OS=Oryctolagus cuniculus OX=9986 GN=SCN9A PE=2 SV=1
Length=1984
Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 124/600 (21%), Positives = 245/600 (41%), Gaps = 109/600 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V V+LV T+ S L + LR R L
Sbjct 1233 IFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1292
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1293 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------- 1342
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
++Q + + S +N + + S+N + + F +G + L+
Sbjct 1343 --KFYQCVNTTDDSRFPTKQVSNRSECFALMNGSQNVRWKNLKVNFDNVG----LRYLSL 1396
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQ 360
+ + F+G+ M + ++ + + ++E V+ + G +GV
Sbjct 1397 LQVATFKGW-MDIMYAAVDSVNVDQQPSYEHNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1455
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQS 419
N Q QK +L G + EE +K +N + + K P P +
Sbjct 1456 NFNQ--QKKKLG--------------GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1499
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
F L + FD ++ N+V++ V +D + +L +N VFI+
Sbjct 1500 KFQGCIFDLVTNQAFDITIMILICLNMVTMMVEKEGQSDYMTD-----VLYWINVVFIIL 1554
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+ +L Y + N+FD V+++L I + + L + P + ++
Sbjct 1555 FTGECVLKLISLR-HYYFTIGWNIFD----FVVVILSIVGMFLAELIETYFVSPTLFRVI 1609
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M++ A +GL +L +V +++AI G+
Sbjct 1610 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYAIFGM 1660
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V N NF+ F +++ L+ + W
Sbjct 1661 SNFAYVKKEAGINDMF--------------------NFETFGNSMICLFQITTSAGWDGL 1700
Query 659 L-----------DAYRRYSGPWSK----------IYFVLWWLVSSVIWVNLFLALILENF 697
L D + + G ++ YFV + ++S ++ VN+++A+ILENF
Sbjct 1701 LAPILNSAPPDCDPKKVHPGSSTEGDCGSPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1760
Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust.
Identities = 61/244 (25%), Positives = 100/244 (41%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV TL L + P
Sbjct 1229 IFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGYSDLGP-- 1282
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1283 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1333
Query 595 IIGINLFRGVI---VALPGNSSLAPANGSAPCGSF-----EQLEYWAN---NFDDFAAAL 643
I+G+NLF G V +S S F Q W N NFD+
Sbjct 1334 IMGVNLFAGKFYQCVNTTDDSRFPTKQVSNRSECFALMNGSQNVRWKNLKVNFDNVGLRY 1393
Query 644 VTLWNLMVVNNW---------QVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W V +D Y + IYFV++ + S +NLF+ +I
Sbjct 1394 LSLLQVATFKGWMDIMYAAVDSVNVDQQPSYEHNLYMYIYFVIFIIFGSFFTLNLFIGVI 1453
Query 694 LENF 697
++NF
Sbjct 1454 IDNF 1457
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 56/300 (19%), Positives = 118/300 (39%), Gaps = 70/300 (23%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L +++ + +++ C+F+ ++ PAE + ++ L+++ + F +G +
Sbjct 127 LFSMLIMCTILTNCIFMTMNN---PAEWTKNVEYTFTGIYTFESLVKIFARGFCVGEFTF 183
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L P N D ++ V + E L ++ L FR L
Sbjct 184 LRDPWNWLDFIVIVFAYLTEFVNLG------------------------NVSALRTFRVL 219
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRGVIVA------ 607
R + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF G +
Sbjct 220 RALKTISVIPGLKTIVGALIQSVKKLSDVIILTVFCLSVFALIGLQLFMGHLKHKCLRKI 279
Query 608 ------------------------LPGNSS-----LAPANGSAPCGSF-----EQLEYWA 633
L G+ + +G P G + +Y
Sbjct 280 ENETLESIMSSIESEEDYKKYFYYLEGSKDALLCGFSTDSGQCPEGYYCVKAGRNPDYGY 339
Query 634 NNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
+FD F+ A + L+ LM + W+ R +G I+FV+ + S +NL LA++
Sbjct 340 TSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVV 399
Score = 42.0 bits (97), Expect = 0.029, Method: Compositional matrix adjust.
Identities = 48/217 (22%), Positives = 101/217 (47%), Gaps = 32/217 (15%)
Query 128 VEVLCLLVFAAD-----LSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
+ V+ +++F + +S++ Y F GW F + +L + + + L++ T +S
Sbjct 1547 INVVFIILFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIE-TYFVSPTL 1605
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+R+ R+ R L++ + ++ L + SLP + ++GLLL + + ++ +FGM FA
Sbjct 1606 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAY 1665
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN----------------NPDVMIPAYSK 284
K++ G + + F+ S+ L + T+A +P + P S
Sbjct 1666 VKKEAGIN--DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSST 1723
Query 285 -----NRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQF 315
+ + IF F+ + +I L ++N+ A+I F
Sbjct 1724 EGDCGSPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1760
>sp|D0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1 OS=Periplaneta
americana OX=6978 PE=1 SV=1
Length=1553
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 64/279 (23%), Positives = 122/279 (44%), Gaps = 40/279 (14%)
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
++ V ++++EM++ +FA+G + Y + D ++ V L+ + A
Sbjct 893 VDYVLTAFFVIEMIIMLFAVGFKKYFTSKWYWLDFIVVVAYLLNFVLMCA---------- 942
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
G+ +L + L +L VFR R + + M VV ST++ V ++ F ILV +++
Sbjct 943 ----GIEAL----QTLRLLRVFRLFRPLSKVNGMQVVTSTLVEAVPHI--FNVILVGIFF 992
Query 592 --VFAIIGINLFRGVIV-ALPGNSSLAPANGSAPCGSFEQLEY-WAN---NFDDFAAALV 644
VFAI+G+ LF G + NS++ + Y W N NFD A +
Sbjct 993 WLVFAIMGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWENSPMNFDHVGNAYL 1052
Query 645 TLWNLMVVNNW-QVFLDAYR---------RYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+L + W Q+ DA R + + +YF+ + + S + LF+ +++
Sbjct 1053 SLLQVATFKGWLQIMNDAIDSREVHKQPIRETNIYMYLYFIFFIVFGSFFILKLFVCILI 1112
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ F + R + L+ T T + + R + +P
Sbjct 1113 DIFRQQ---RRKAEGLSATDSRTQLIYRRAVMRTMSAKP 1148
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 62/277 (22%), Positives = 121/277 (44%), Gaps = 36/277 (13%)
Query 450 CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RGYLSYPSNVFD 505
C+F+++ PA + +IL + VF+ Y +E+++KV A G YL P N D
Sbjct 154 CIFMIM-----PATQTTYILEL---VFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLD 205
Query 506 GLLTVV---LLVLEISTLAVYRLPH-----------PGWRPEMVGLLSLWDMTRMLNMLI 551
L+T++ LV+++ L R PGWR +V LSL + +L+
Sbjct 206 FLVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWR-TIVDALSLSITSLKDLVLL 264
Query 552 VFRFLRIIPSMKL---MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF---RGVI 605
+ L + + L M V+ + ++G ++ + + + +
Sbjct 265 LLFSLFVFAVLGLQIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIE 324
Query 606 VALPGNSS---LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS + P + G Y +FD F A ++++ L+ ++ W+
Sbjct 325 YPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLA 384
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
R +GPW ++F++ + ++N LA+++ ++ H
Sbjct 385 LRSAGPWHILFFIIVVFYGTFCFLNFILAVVVMSYTH 421
Score = 43.5 bits (101), Expect = 0.010, Method: Compositional matrix adjust.
Identities = 58/226 (26%), Positives = 96/226 (42%), Gaps = 54/226 (24%)
Query 449 ICVFLVLDADVLPAERDDF------ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
I V +VL+ + + D IL N +F Y++E +LK+ AL + Y N
Sbjct 525 IAVIIVLNITFMALDHHDMNIEFERILRTGNYIFTSIYIVEAVLKIIALSPKFYFKDSWN 584
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
VFD + VV +LE+ E V LS++ R +L VFR + P++
Sbjct 585 VFD-FIIVVFAILELGL-------------EGVQGLSVF---RSFRLLRVFRLAKFWPTL 627
Query 563 -KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
M+V+ + V M ++ ++ ++FAIIG+ LF + N P +G
Sbjct 628 NNFMSVMTKSYGAFVNVMY----VMFLLLFIFAIIGMQLFGMNYI---DNMERFP-DGDL 679
Query 622 PCGSFEQLEYWANNFDDFAAALV------------TLWNLMVVNNW 655
P W NF DF + + ++W+ M+V +W
Sbjct 680 P--------RW--NFTDFLHSFMIVFRALCGEWIESMWDCMLVGDW 715
Score = 34.7 bits (78), Expect = 4.4, Method: Compositional matrix adjust.
Identities = 58/276 (21%), Positives = 110/276 (40%), Gaps = 59/276 (21%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVLLV-LEISTLAVYRL 525
+L LN +FI+ + +E ++KV GLR Y P N+ D L V+ + L +S +
Sbjct 1201 VLDYLNLIFIIIFFVECVIKV--SGLRHHYFKDPWNIIDFLYVVLAIAGLMLSDVIEKYF 1258
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
P + R+L +L V R LR S + M ++ + ++ + +
Sbjct 1259 ISPT-------------LLRILRILRVGRLLRYFQSARGMRLLLLALRKALRTLFNVSFL 1305
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
L V+ +V+A+ G+ F + A G+ + + NF F +++
Sbjct 1306 LFVIMFVYAVFGMEFFMHIRDA----------------GAIDDVY----NFKTFGQSIIL 1345
Query 646 LWNLMVVNNWQ-VFL-----------DAYRRYSGPWSK-----IYFVLWWLVSSVIWVNL 688
L+ L W V+ D Y G Y V + +++ ++ +N+
Sbjct 1346 LFQLATSAGWDGVYFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLIITCLVVINM 1405
Query 689 FLALILENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
+ A+IL+ L ++ G + Y M E+
Sbjct 1406 YAAVILDYVLEVYEDSKE-----GLTDDDYDMFFEV 1436
>sp|Q20JQ7|SC4AB_DANRE Sodium channel protein type 4 subunit alpha
B OS=Danio rerio OX=7955 GN=scn4ab PE=2 SV=1
Length=1784
Score = 51.2 bits (121), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 125/602 (21%), Positives = 250/602 (42%), Gaps = 113/602 (19%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
VF ++ +K +G+ + N W +++ VSL+ T ++ L + LR R L
Sbjct 1016 VFVVEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYSELGAIKSLRTLRAL 1075
Query 191 RPFFLLQNSSMMKKTL-KCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG +
Sbjct 1076 RPLRALSRFEGMRVVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYYCFNET 1135
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ N+ + T L+ +P+V + + I F +G M L
Sbjct 1136 SEEVFDHNVVNNKTDCYELMEF--HPEV---RWMNGK------INFDNVG----MGYLAL 1180
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKPQ 360
+ + F+G+ M + +++ R + ++ +E V+ + G +GV
Sbjct 1181 LQVATFKGW-MDIMYSAVDSRAIESQPVYEANLYMYIYFVIFIIFGSFFTLNLFIGVIID 1239
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEY 417
N Q QK +L G+ + EE +K +N + + S + P PRP
Sbjct 1240 NFNQ--QKAKLG--------------GTDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP-- 1281
Query 418 QSPFLQSAQFLF-GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
+ Q F F +FD ++ N+V+ ++++ D AE ++ IL +N F
Sbjct 1282 -TNCCQGLVFDFVTQQFFDIFIMVMICLNMVT----MMVETDDQSAEIEE-ILFYINFAF 1335
Query 477 IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMV 535
I+ + E +LK+ AL Y S N+FD V+++L I + + L + P +
Sbjct 1336 IILFTGECVLKITALRYH-YFSIGWNIFD----FVVVILSILGIGLADLIEKYFVSPTLF 1390
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
++ L + R+L ++ + +R + +M++ A +GL +L ++ ++F+I
Sbjct 1391 RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGL---------LLFLIMFIFSI 1441
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
G++ F V + + + NF+ F +++ ++ + W
Sbjct 1442 FGMSNFAYVKKEVGIDDMM--------------------NFETFGNSIICMFMITTSAGW 1481
Query 656 QVFL--------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILE 695
L D P S ++F + ++S ++ VN+++A+ILE
Sbjct 1482 DGLLAPILNSPPDCDPDVDNPGSTTRGNCGNAAVGIVFFCSYIVMSFLVVVNMYIAIILE 1541
Query 696 NF 697
NF
Sbjct 1542 NF 1543
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 54/207 (26%), Positives = 97/207 (47%), Gaps = 27/207 (13%)
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLVCHEPLRIRRLL 190
C+L A L + GW F + +L L + + L++ + VS +L +R+ R+
Sbjct 1343 CVLKITA-LRYHYFSIGWNIFDFVVVILSILGIGLADLIEKYFVSPTL--FRVIRLARIG 1399
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L++ + ++ L + SLP + ++GLLL + + +F++FGM FA K++ G D
Sbjct 1400 RVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSNFAYVKKEVGID-- 1457
Query 251 RLTYFQNLPESLTSLLVLLTTAN---------------NPDVMIPAYSK-----NRAYAI 290
+ F+ S+ + ++ T+A +PDV P + N A I
Sbjct 1458 DMMNFETFGNSIICMFMITTSAGWDGLLAPILNSPPDCDPDVDNPGSTTRGNCGNAAVGI 1517
Query 291 -FFIVFTVIGSLFLMNLLTAIIYSQFR 316
FF + V+ L ++N+ AII F
Sbjct 1518 VFFCSYIVMSFLVVVNMYIAIILENFN 1544
Score = 47.0 bits (110), Expect = 7e-04, Method: Compositional matrix adjust.
Identities = 62/253 (25%), Positives = 108/253 (43%), Gaps = 39/253 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
IL + VF +++EMLLK A G + Y + D L+ V L+ + + Y
Sbjct 1005 ILEYADQVFTYVFVVEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYS--- 1061
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
E+ + SL R L L R L M++ VV + ++G + ++ + +
Sbjct 1062 -----ELGAIKSL----RTLRALRPLRALSRFEGMRV--VVVNALVGAIPSIFNVLLVCL 1110
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAP-----ANGSAPCGSFEQLEY-----WAN--- 634
+ + +F+I+G+NLF G +S N C +E +E+ W N
Sbjct 1111 IFWLIFSIMGVNLFAGKFYYCFNETSEEVFDHNVVNNKTDC--YELMEFHPEVRWMNGKI 1168
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVI 684
NFD+ + L + W + D+ S P + IYFV++ + S
Sbjct 1169 NFDNVGMGYLALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYMYIYFVIFIIFGSFF 1228
Query 685 WVNLFLALILENF 697
+NLF+ +I++NF
Sbjct 1229 TLNLFIGVIIDNF 1241
Score = 39.7 bits (91), Expect = 0.15, Method: Compositional matrix adjust.
Identities = 30/134 (22%), Positives = 61/134 (46%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L I N VF + EM+LK+ AL Y N+FD ++ + LV
Sbjct 599 VLAIGNLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLV------------- 645
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
M+ + + R ++ VF+ + P++ ++ + +G + N+ +L
Sbjct 646 ----ELMLADVEGLSVLRSFRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 698
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 699 IIVFIFAVVGMQLF 712
Score = 34.3 bits (77), Expect = 5.9, Method: Compositional matrix adjust.
Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 89/288 (31%)
Query 471 ILNCVFIVYYLLEMLLKV----FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLP 526
IL VF Y E ++KV F +G +L P N D +V+ ++ L
Sbjct 158 ILEYVFTGIYTFEAMVKVLSRGFCIGDFTFLRDPWNWLD------FMVISMAYLT----- 206
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
E V L ++ + L FR LR + ++ ++ + + V L+Q+++ ++
Sbjct 207 ------EFVDLGNI-------SALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLADVM 253
Query 587 VVVYY---VFAIIGINLF----RGVIVALP------------GNSSLAPANGSAP----- 622
++ + VFA+IG+ LF R V P N + NG+A
Sbjct 254 ILTVFCLSVFALIGLQLFMGNLRQKCVLWPPVGWYSDNLTVLSNYTDINGNGTANSTFDY 313
Query 623 ---------------------CGSFEQL----------------EYWANNFDDFAAALVT 645
CG+ Y ++D+F A +
Sbjct 314 QKYINSEENYYYVPGQMDPLVCGNSSDAGLCPEGYICLKAGRNPNYGYTSYDNFGWAFLA 373
Query 646 LWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
L+ LM + W+ R +G I+FV+ + S +NL LA++
Sbjct 374 LFRLMTQDFWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVV 421
>sp|O08562|SCN9A_RAT Sodium channel protein type 9 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn9a PE=1 SV=1
Length=1984
Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust.
Identities = 56/244 (23%), Positives = 100/244 (41%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y + D L+ V LV TL L + P
Sbjct 1230 IFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGYSDLGP-- 1283
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L L R LR + + M VV + ++G + ++ + ++ + +F+
Sbjct 1284 ---------IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1334
Query 595 IIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFEQLE---YWAN---NFDDFAAAL 643
I+G+NLF G + + + C + + W N NFD+
Sbjct 1335 IMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGY 1394
Query 644 VTLWNLMVVNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + D+ P + IYFV++ + S +NLF+ +I
Sbjct 1395 LSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVI 1454
Query 694 LENF 697
++NF
Sbjct 1455 IDNF 1458
Score = 47.4 bits (111), Expect = 6e-04, Method: Compositional matrix adjust.
Identities = 75/348 (22%), Positives = 147/348 (42%), Gaps = 78/348 (22%)
Query 381 EKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYL 437
+K + G + EE +K +N + + S + P PRP + F FD +
Sbjct 1461 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNK----------FQGCIFDLV 1510
Query 438 GNLIALANLVSICVFLVLDADVLPAERD------DFILGILNCVFIVYYLLEMLLKVFAL 491
N A ++I V + L+ + E++ D++L +N VFI+ + E +LK+ +L
Sbjct 1511 TNQ---AFDITIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISL 1567
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRMLNML 550
Y + N+FD V+++L I + + + + P + ++ L + R+L ++
Sbjct 1568 -RHYYFTVGWNIFD----FVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLI 1622
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPG 610
+ +R + +M++ A +GL +L +V +++AI G++ F V
Sbjct 1623 KGAKGIRTLLFALMMSLPALFNIGL---------LLFLVMFIYAIFGMSNFAYVKKEAGI 1673
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DA 661
N NF+ F +++ L+ + W L D
Sbjct 1674 NDMF--------------------NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDC 1713
Query 662 YRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
+ P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1714 DPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1761
Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust.
Identities = 65/274 (24%), Positives = 105/274 (38%), Gaps = 48/274 (18%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLV--VSLVDWTVSLS-LVCHEPLRIRRLL 190
+F ++ +K +G+ + N W L +L+V V V+LV T+ S L + LR R L
Sbjct 1234 IFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRAL 1293
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-----KQDD 245
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG D
Sbjct 1294 RPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTD 1353
Query 246 GQD------------------------RERLTYFQNLPESLTSLLVLLTTANNPDVMI-- 279
G + F N+ SLL + T D+M
Sbjct 1354 GSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAA 1413
Query 280 ---------PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
P Y + I+F++F + GS F +NL +I F K +F
Sbjct 1414 VDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM- 1472
Query 331 RLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
T + ++M G PQ +P N Q
Sbjct 1473 ---TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQ 1503
Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust.
Identities = 58/302 (19%), Positives = 118/302 (39%), Gaps = 72/302 (24%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L +++ + +++ C+F+ L P E + ++ L+++L + F +G +
Sbjct 127 LFSMLIMCTILTNCIFMTLSN---PPEWTKNVEYTFTGIYTFESLIKILARGFCVGEFTF 183
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L P N D ++ V + E L ++ L FR L
Sbjct 184 LRDPWNWLDFVVIVFAYLTEFVNLG------------------------NVSALRTFRVL 219
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRGVI------VA 607
R + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF G +
Sbjct 220 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKE 279
Query 608 LPGNSSL-------------------------------APANGSAPCG-----SFEQLEY 631
L N +L + +G P G + +Y
Sbjct 280 LEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDY 339
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
+FD F+ A + L+ LM + W+ R +G I+FV+ + S +NL LA
Sbjct 340 GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399
Query 692 LI 693
++
Sbjct 400 VV 401
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 40/174 (23%), Positives = 84/174 (48%), Gaps = 28/174 (16%)
Query 433 YFDYLGNLIALANLVSICV-----FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
YF + + LA ++IC+ F+ ++ + E + +L + N +F + EM+LK
Sbjct 737 YFIVMDPFVDLA--ITICIVLNTLFMAMEHHPMTEEFKN-VLAVGNLIFTGIFAAEMVLK 793
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ A+ Y N+FD L+ V L ++E+ + ++ GL L R
Sbjct 794 LIAMDPYEYFQVGWNIFDSLI-VTLSLIEL------------FLADVEGLSVL----RSF 836
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+L VF+ + P++ ++ + +G + N+ +L ++ ++FA++G+ LF
Sbjct 837 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLAIIVFIFAVVGMQLF 887
Score = 41.6 bits (96), Expect = 0.037, Method: Compositional matrix adjust.
Identities = 47/201 (23%), Positives = 95/201 (47%), Gaps = 29/201 (14%)
Query 140 LSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVD-WTVSLSLVCHEPLRIRRLLRPFFLL 196
+S++ Y F GW F + +L + + + +++ + VS +L +R+ R+ R L+
Sbjct 1565 ISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLF--RVIRLARIGRILRLI 1622
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ + ++ L + SLP + ++GLLL + + ++ +FGM FA K++ G + + F+
Sbjct 1623 KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIN--DMFNFE 1680
Query 257 NLPESLTSLLVLLTTAN----------------NPDVMIPAYS-----KNRAYAIF-FIV 294
S+ L + T+A +P + P S N + IF F+
Sbjct 1681 TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS 1740
Query 295 FTVIGSLFLMNLLTAIIYSQF 315
+ +I L ++N+ A+I F
Sbjct 1741 YIIISFLVVVNMYIAVILENF 1761
>sp|Q8BVN3|CTSR4_MOUSE Cation channel sperm-associated protein
4 OS=Mus musculus OX=10090 GN=Catsper4 PE=1 SV=1
Length=442
Score = 49.7 bits (117), Expect = 7e-05, Method: Compositional matrix adjust.
Identities = 46/187 (25%), Positives = 90/187 (48%), Gaps = 21/187 (11%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSLVC-HEPLRIRRLLRPFFLLQNSSM 201
G+L G+ F K+ W +L + +V ++ + + L +V PLR+ RL+ ++
Sbjct 119 GWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEP--- 175
Query 202 MKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPES 261
+ + +K I S+P++A+V L+ + +F++FG+ LF +FQN+ +
Sbjct 176 LARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVP---------KHFQNMGVA 226
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAY------AIFFIVFTVIGSLFLMNLLTAIIYSQF 315
L +L + +T D+ R Y AI+F VF +G+ +NL ++ +
Sbjct 227 LYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNL 286
Query 316 RGYLMKS 322
+MK+
Sbjct 287 EQ-MMKT 292
>sp|Q99250|SCN2A_HUMAN Sodium channel protein type 2 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN2A PE=1 SV=3
Length=2005
Score = 50.1 bits (118), Expect = 8e-05, Method: Compositional matrix adjust.
Identities = 57/244 (23%), Positives = 102/244 (42%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV +L L +
Sbjct 1248 VFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLV----SLTANALGY------- 1296
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1297 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query 595 IIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G ++ ++ N + C + Q W N NFD+
Sbjct 1353 IMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGY 1412
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1413 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Query 694 LENF 697
++NF
Sbjct 1473 IDNF 1476
Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 124/609 (20%), Positives = 242/609 (40%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1252 IFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFA GK
Sbjct 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFA-GK-------- 1362
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + T + ++ NN N+ + + F +G + L+
Sbjct 1363 ----FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVG----LGYLS 1414
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
+ + F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1415 LLQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVII 1473
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1474 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPA 1517
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1518 NK----------FQGMVFDFVTKQVFD---ISIMILICLNMVTMMVETDDQSQEMTNILY 1564
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1565 WINLVFIVLFTGECVLKLISLRYY-YFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1619
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1670
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1671 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1710
Query 650 MVVNNWQVFL-----------DAYRRYSGPWSK----------IYFVLWWLVSSVIWVNL 688
W L D + + G K +FV + ++S ++ VN+
Sbjct 1711 TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1771 YIAVILENF 1779
Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 32/134 (24%), Positives = 62/134 (46%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + N VF + EM LK+ A+ Y N+FDG + V L ++E+ V L
Sbjct 790 VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI-VSLSLMELGLANVEGL-- 846
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ R +L VF+ + P++ ++ + +G + N+ +L
Sbjct 847 --------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 889
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 890 IIVFIFAVVGMQLF 903
Score = 39.3 bits (90), Expect = 0.19, Method: Compositional matrix adjust.
Identities = 68/354 (19%), Positives = 129/354 (36%), Gaps = 95/354 (27%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L N++ + +++ CVF+ + P + + ++ L+++L + F L +
Sbjct 130 LFNMLIMCTILTNCVFMTMSN---PPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 186
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
L P N D + V E L ++ L FR L
Sbjct 187 LRDPWNWLDFTVITFAYVTEFVDLG------------------------NVSALRTFRVL 222
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY---VFAIIGINLFRGVIVAL----- 608
R + ++ ++ + + V L+Q+++ ++++ + VFA+IG+ LF G +
Sbjct 223 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWP 282
Query 609 PGNSS-----------------------------------------LAPANGSAPCGSFE 627
P NSS L N + CG+
Sbjct 283 PDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSS 342
Query 628 QL----------------EYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
Y +FD F+ A ++L+ LM + W+ R +G
Sbjct 343 DAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM 402
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
I+FVL + S +NL LA++ ++ ++ L+ A EA +Q +E L
Sbjct 403 IFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQMLEQL 453
>sp|O42398|CAC1S_CHICK Voltage-dependent L-type calcium channel
subunit alpha-1S (Fragment) OS=Gallus gallus OX=9031 GN=CACNA1S
PE=2 SV=1
Length=281
Score = 48.9 bits (115), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 59/259 (23%), Positives = 116/259 (45%), Gaps = 45/259 (17%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
++P+ ++ YF+YL + + N +IC L + AE + + ILN F
Sbjct 44 KNPYQYQIWYVVTSSYFEYLMFFLIMLN--TIC--LGMQHYNQSAEMNH-VSDILNVAFT 98
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
V + LEM+LK+ A +GY P NVFD L +++ I + + + P
Sbjct 99 VLFTLEMILKLMAFKAKGYFGDPWNVFDFL----IVIGSIIDVILSEIDDPD-------- 146
Query 538 LSLWDMTRM-LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF---GGILVVVYYVF 593
D +R+ + +FR +R++ + V + + +++ +A ++V++++++
Sbjct 147 ----DNSRVSITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIY 202
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
A+IG+ +F +A +G+ + NNF F A++ L+
Sbjct 203 AVIGMQMF----------GKIAMVDGTQINRN--------NNFQTFPQAVLLLFRCATGE 244
Query 654 NWQ-VFLD-AYRRYSGPWS 670
WQ + LD +Y + P S
Sbjct 245 AWQEILLDCSYGKRCDPES 263
Score = 34.7 bits (78), Expect = 3.2, Method: Compositional matrix adjust.
Identities = 36/135 (27%), Positives = 61/135 (45%), Gaps = 8/135 (6%)
Query 130 VLCLLVFAADLSVKGYLFG--WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIR 187
+L L+ F A KGY FG W F L ++G ++ +++S +D S V R+
Sbjct 106 ILKLMAFKA----KGY-FGDPWNVFDF-LIVIGSIIDVILSEIDDPDDNSRVSITFFRLF 159
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R++R LL ++ L S + V LL+ + ++ + GM +F DG
Sbjct 160 RVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGT 219
Query 248 DRERLTYFQNLPESL 262
R FQ P+++
Sbjct 220 QINRNNNFQTFPQAV 234
>sp|B1AWN6|SCN2A_MOUSE Sodium channel protein type 2 subunit alpha
OS=Mus musculus OX=10090 GN=Scn2a PE=1 SV=1
Length=2006
Score = 50.1 bits (118), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 57/244 (23%), Positives = 102/244 (42%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV +L L +
Sbjct 1249 VFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLV----SLTANALGY------- 1297
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1298 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1353
Query 595 IIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G ++ ++ N + C + Q W N NFD+
Sbjct 1354 IMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVGLGY 1413
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1414 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1473
Query 694 LENF 697
++NF
Sbjct 1474 IDNF 1477
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 124/609 (20%), Positives = 242/609 (40%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1253 IFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1312
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFA GK
Sbjct 1313 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFA-GK-------- 1363
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + T + ++ NN N+ + + F +G + L+
Sbjct 1364 ----FYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVG----LGYLS 1415
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
+ + F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1416 LLQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVII 1474
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1475 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPA 1518
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1519 NK----------FQGMVFDFVTKQVFD---ISIMILICLNMVTMMVETDDQSQEMTNILY 1565
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1566 WINLVFIVLFTGECVLKLISL-RHYYFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1620
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1621 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1671
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1672 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1711
Query 650 MVVNNWQVFL-----------DAYRRYSGPWSK----------IYFVLWWLVSSVIWVNL 688
W L D + + G K +FV + ++S ++ VN+
Sbjct 1712 TTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1771
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1772 YIAVILENF 1780
Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 32/134 (24%), Positives = 62/134 (46%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + N VF + EM LK+ A+ Y N+FDG + V L ++E+ V L
Sbjct 791 VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI-VSLSLMELGLANVEGL-- 847
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ R +L VF+ + P++ ++ + +G + N+ +L
Sbjct 848 --------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 890
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 891 IIVFIFAVVGMQLF 904
Score = 37.4 bits (85), Expect = 0.60, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 337 LCGNSSDA---GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLT 393
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S +NL LA++ ++ ++ L+ A EA +Q +
Sbjct 394 LRAAGKTYMIFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQML 450
Query 723 ELL 725
E L
Sbjct 451 EQL 453
>sp|P04775|SCN2A_RAT Sodium channel protein type 2 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn2a PE=1 SV=1
Length=2005
Score = 50.1 bits (118), Expect = 9e-05, Method: Compositional matrix adjust.
Identities = 57/244 (23%), Positives = 102/244 (42%), Gaps = 36/244 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
VF ++LEMLLK A G + Y + D L+ V LV +L L +
Sbjct 1248 VFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLV----SLTANALGY------- 1296
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + L L R LR + + M VV + +LG + ++ + ++ + +F+
Sbjct 1297 ----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFS 1352
Query 595 IIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF---EQLEYWAN---NFDDFAAAL 643
I+G+NLF G ++ ++ N + C + Q W N NFD+
Sbjct 1353 IMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVGLGY 1412
Query 644 VTLWNLMVVNNWQVFLDAY----------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + + +YFV++ + S +NLF+ +I
Sbjct 1413 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
Query 694 LENF 697
++NF
Sbjct 1473 IDNF 1476
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 124/609 (20%), Positives = 242/609 (40%), Gaps = 127/609 (21%)
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T + L + LR R L
Sbjct 1252 IFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFA GK
Sbjct 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFA-GK-------- 1362
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA--YAIFFIVFTVIGSLFLMNLLT 308
F + T + ++ NN N+ + + F +G + L+
Sbjct 1363 ----FYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVG----LGYLS 1414
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE---------VLSSMVGEGGAFPQAVGVKP 359
+ + F+G+ M + ++ R + + +E V+ + G +GV
Sbjct 1415 LLQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVII 1473
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR--SVVKEHP-PRPE 416
N Q +K + G + EE +K +N + + S + P PRP
Sbjct 1474 DNFNQ----------------QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPA 1517
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F FD++ + +SI + + L+ + E DD IL
Sbjct 1518 NK----------FQGMVFDFVTKQVFD---ISIMILICLNMVTMMVETDDQSQEMTNILY 1564
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+N VFIV + E +LK+ +L Y + N+FD V+++L I + + L +
Sbjct 1565 WINLVFIVLFTGECVLKLISL-RHYYFTIGWNIFD----FVVVILSIVGMFLAELIEKYF 1619
Query 531 -RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
P + ++ L + R+L ++ + +R + +M++ A +GL +L +V
Sbjct 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL---------LLFLV 1670
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G++ F V + + NF+ F +++ L+ +
Sbjct 1671 MFIYAIFGMSNFAYVKREVGIDDMF--------------------NFETFGNSMICLFQI 1710
Query 650 MVVNNWQVFL-----------DAYRRYSGPWSK----------IYFVLWWLVSSVIWVNL 688
W L D + + G K +FV + ++S ++ VN+
Sbjct 1711 TTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
Query 689 FLALILENF 697
++A+ILENF
Sbjct 1771 YIAVILENF 1779
Score = 43.1 bits (100), Expect = 0.012, Method: Compositional matrix adjust.
Identities = 32/134 (24%), Positives = 62/134 (46%), Gaps = 20/134 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L + N VF + EM LK+ A+ Y N+FDG + V L ++E+ V L
Sbjct 790 VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI-VSLSLMELGLANVEGL-- 846
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ R +L VF+ + P++ ++ + +G + N+ +L
Sbjct 847 --------------SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL---VLA 889
Query 588 VVYYVFAIIGINLF 601
++ ++FA++G+ LF
Sbjct 890 IIVFIFAVVGMQLF 903
Score = 37.4 bits (85), Expect = 0.62, Method: Compositional matrix adjust.
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 11/123 (9%)
Query 608 LPGNSSLAPANGSAPCG-----SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
L GNSS A G P G + Y +FD F+ A ++L+ LM + W+
Sbjct 337 LCGNSSDA---GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLT 393
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
R +G I+FVL + S +NL LA++ ++ ++ L+ A EA +Q +
Sbjct 394 LRAAGKTYMIFFVLVIFLGSFYLINLILAVVA--MAYEEQNQATLEE-AEQKEAEFQQML 450
Query 723 ELL 725
E L
Sbjct 451 EQL 453
>sp|A2ARP9|CTSR2_MOUSE Cation channel sperm-associated protein
2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2
Length=588
Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 57/226 (25%), Positives = 104/226 (46%), Gaps = 48/226 (21%)
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL-----SLWDMTRMLNMLIVFRFL 556
NVFD +T++ L+ PE+V LL S+W ++L + V R L
Sbjct 176 NVFDFFVTLLSLL-----------------PELVVLLGVPAHSVW--LQLLRVCRVLRSL 216
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
++ + + V+ ++ +++M +L++ +Y+FA+ G+ FR
Sbjct 217 KLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFR-------------- 262
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW-QVFLDAYR--RYSGPWSKIY 673
+ E LEY F D +LVT++ L +++W V D ++ S +S IY
Sbjct 263 ---EYSRSTIEGLEY-NMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIY 318
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQ 719
+LW L+ S+I+ N+ +A+++ NF + RS L E Y+
Sbjct 319 VILWLLLGSIIFRNIIVAMMVTNFQ---NIRSELSEEMSHLEVQYK 361
>sp|Q8BXR5|NALCN_MOUSE Sodium leak channel NALCN OS=Mus musculus
OX=10090 GN=Nalcn PE=1 SV=2
Length=1738
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 58/254 (23%), Positives = 105/254 (41%), Gaps = 37/254 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 918 LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLC------- 970
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
W P+ V S + +L L R +++P M+ VV G + + +L+
Sbjct 971 -WMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMR--KVVRELFSGF-KEIFLVSILLLT 1026
Query 589 VYYVFAIIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFE 627
+ VFA G+ LF G + V++ N +L G G F
Sbjct 1027 LMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPG-FW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENF 697
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANF 1159
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 63/289 (22%), Positives = 117/289 (40%), Gaps = 61/289 (21%)
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
D+F L F V + LE LLK++ LG GY+S + F+ LL + +TL VY
Sbjct 416 DEFYLA--EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIG------TTLHVY- 466
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
P++ + F+ LR++ +K+ + V + + G
Sbjct 467 -------PDLYH-----------SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGS 508
Query 585 ILVV---VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAA 641
++V + V + I + +F V E+L+ F F
Sbjct 509 LVVFTASLLIVMSAISLQMFCFV----------------------EELD----RFTTFPR 542
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
A ++++ ++ W +D G P IYF+L+ L +++I ++LF+A+IL+N
Sbjct 543 AFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNL 602
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP 746
D + Q A + + L R + P ++ ++S+ P
Sbjct 603 ELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMV-KISKLP 650
Score = 42.4 bits (98), Expect = 0.023, Method: Compositional matrix adjust.
Identities = 76/343 (22%), Positives = 134/343 (39%), Gaps = 88/343 (26%)
Query 387 GSVLLSAEE--FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALA 444
G+ LL+ ++ ++ L + L + PPRP+ F + H +F L+ LA
Sbjct 1164 GTALLTVDQRRWEDLKSRLKIAQPLHLPPRPD-NDGFRAKMYDITQHPFFKRTIALLVLA 1222
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
V + V +D V L ++ VF ++LE+ +K+ A+ G+ N +
Sbjct 1223 QSVLLSVKWDVDDPVTVP------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRY 1276
Query 505 DGLLT---VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPS 561
D L+T VV +VL + L Y M+G +IVFRF I
Sbjct 1277 DLLVTSLGVVWVVLHFALLNAYTY--------MMGAC-----------VIVFRFFSICGK 1317
Query 562 MKLMAVVASTVLGLVQNMRAF----GGILVVVYYVFAII--------GINLFRGVIVALP 609
+ ++ TV+ V ++F G L+++ Y FA + G N+ R +
Sbjct 1318 HVTLKMLLLTVV--VSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSA 1375
Query 610 G---------------NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN 654
G N + P + ++ YWA + ++A AL
Sbjct 1376 GKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL----------- 1424
Query 655 WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+YF ++++ + I +NL +A+I+ENF
Sbjct 1425 -----------------MYFCSFYVIIAYIMLNLLVAIIVENF 1450
Score = 41.6 bits (96), Expect = 0.038, Method: Compositional matrix adjust.
Identities = 69/296 (23%), Positives = 127/296 (43%), Gaps = 52/296 (18%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL-RGYLS 498
+ A+ +++S+C+ + + P + ++ L+ + + Y EM+ K+ G+ +G S
Sbjct 44 ICAIISVISVCMNTPMTFEHYPPLQ--YVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSS 101
Query 499 YPSN---VFDGLLTVVL---LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
Y + VFDG + L LVL++ +A ++V +S W M R+ LI+
Sbjct 102 YVKDRWCVFDGFMVFCLWVSLVLQVFEIA-----------DIVDQMSPWGMLRIPRPLIM 150
Query 553 FRFLRIIPSMKLMAVVASTVLGLV-QNMRAFGGILVVVYYVFAIIGINLFRG------VI 605
R RI +L + +L + + + L+ ++ I+G+ +F V
Sbjct 151 IRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVN 210
Query 606 VALPGN---SSLA-PANGSAP-------------CGSFEQL-----EYWANNFDDFAAAL 643
PGN +SLA P +P C E L E + F++ ++
Sbjct 211 DTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSI 270
Query 644 VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV--NLFLALILENF 697
T++ W VFL S P + YF L+ + W+ N+F+A+I+E F
Sbjct 271 FTVYEASSQEGW-VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
>sp|Q8IZF0|NALCN_HUMAN Sodium leak channel NALCN OS=Homo sapiens
OX=9606 GN=NALCN PE=1 SV=1
Length=1738
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 58/254 (23%), Positives = 105/254 (41%), Gaps = 37/254 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 918 LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLC------- 970
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
W P+ V S + +L L R +++P M+ VV G + + +L+
Sbjct 971 -WMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMR--KVVRELFSGF-KEIFLVSILLLT 1026
Query 589 VYYVFAIIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFE 627
+ VFA G+ LF G + V++ N +L G G F
Sbjct 1027 LMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPG-FW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENF 697
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANF 1159
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 63/289 (22%), Positives = 117/289 (40%), Gaps = 61/289 (21%)
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
D+F L F V + LE LLK++ LG GY+S + F+ LL + +TL VY
Sbjct 416 DEFYLA--EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIG------TTLHVY- 466
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
P++ + F+ LR++ +K+ + V + + G
Sbjct 467 -------PDLYH-----------SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGS 508
Query 585 ILVV---VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAA 641
++V + V + I + +F V E+L+ F F
Sbjct 509 LVVFTASLLIVMSAISLQMFCFV----------------------EELD----RFTTFPR 542
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
A ++++ ++ W +D G P IYF+L+ L +++I ++LF+A+IL+N
Sbjct 543 AFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNL 602
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP 746
D + Q A + + L R + P ++ ++S+ P
Sbjct 603 ELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMV-KISKLP 650
Score = 42.0 bits (97), Expect = 0.024, Method: Compositional matrix adjust.
Identities = 77/344 (22%), Positives = 136/344 (40%), Gaps = 90/344 (26%)
Query 387 GSVLLSAEE--FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALA 444
G+ LL+ ++ ++ L + L + PPRP+ F + H +F L+ LA
Sbjct 1164 GTALLTVDQRRWEDLKSRLKIAQPLHLPPRPD-NDGFRAKMYDITQHPFFKRTIALLVLA 1222
Query 445 NLVSICV-FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV 503
V + V + V D +P L ++ VF ++LE+ +K+ A+ G+ N
Sbjct 1223 QSVLLSVKWDVEDPVTVP-------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNR 1275
Query 504 FDGLLT---VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
+D L+T VV +VL + L Y M+G +IVFRF I
Sbjct 1276 YDLLVTSLGVVWVVLHFALLNAYTY--------MMGAC-----------VIVFRFFSICG 1316
Query 561 SMKLMAVVASTVLGLVQNMRAF----GGILVVVYYVFAII--------GINLFRGVIVAL 608
+ ++ TV+ V ++F G L+++ Y FA + G N+ R +
Sbjct 1317 KHVTLKMLLLTVV--VSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSS 1374
Query 609 PG---------------NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
G N + P + ++ YWA + ++A AL
Sbjct 1375 AGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL---------- 1424
Query 654 NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+YF ++++ + I +NL +A+I+ENF
Sbjct 1425 ------------------MYFCSFYVIIAYIMLNLLVAIIVENF 1450
Score = 41.2 bits (95), Expect = 0.040, Method: Compositional matrix adjust.
Identities = 69/296 (23%), Positives = 127/296 (43%), Gaps = 52/296 (18%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL-RGYLS 498
+ A+ +++S+C+ + + P + ++ L+ + + Y EM+ K+ G+ +G S
Sbjct 44 ICAIISVISVCMNTPMTFEHYPPLQ--YVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSS 101
Query 499 YPSN---VFDGLLTVVL---LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
Y + VFDG + L LVL++ +A ++V +S W M R+ LI+
Sbjct 102 YVKDRWCVFDGFMVFCLWVSLVLQVFEIA-----------DIVDQMSPWGMLRIPRPLIM 150
Query 553 FRFLRIIPSMKLMAVVASTVLGLV-QNMRAFGGILVVVYYVFAIIGINLFRG------VI 605
R RI +L + +L + + + L+ ++ I+G+ +F V
Sbjct 151 IRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVN 210
Query 606 VALPGN---SSLA-PANGSAP-------------CGSFEQL-----EYWANNFDDFAAAL 643
PGN +SLA P +P C E L E + F++ ++
Sbjct 211 DTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSI 270
Query 644 VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV--NLFLALILENF 697
T++ W VFL S P + YF L+ + W+ N+F+A+I+E F
Sbjct 271 FTVYEAASQEGW-VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
>sp|Q6Q760|NALCN_RAT Sodium leak channel NALCN OS=Rattus norvegicus
OX=10116 GN=Nalcn PE=1 SV=1
Length=1738
Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust.
Identities = 58/254 (23%), Positives = 105/254 (41%), Gaps = 37/254 (15%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 918 LQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLC------- 970
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
W P+ V S + +L L R +++P M+ VV G + + +L+
Sbjct 971 -WMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMR--KVVRELFSGF-KEIFLVSILLLT 1026
Query 589 VYYVFAIIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFE 627
+ VFA G+ LF G + V++ N +L G G F
Sbjct 1027 LMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPG-FW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENF 697
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANF 1159
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 63/289 (22%), Positives = 117/289 (40%), Gaps = 61/289 (21%)
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
D+F L F V + LE LLK++ LG GY+S + F+ LL + +TL VY
Sbjct 416 DEFYLA--EVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIG------TTLHVY- 466
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
P++ + F+ LR++ +K+ + V + + G
Sbjct 467 -------PDLYH-----------SQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGS 508
Query 585 ILVV---VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAA 641
++V + V + I + +F V E+L+ F F
Sbjct 509 LVVFTASLLIVMSAISLQMFCFV----------------------EELD----RFTTFPR 542
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
A ++++ ++ W +D G P IYF+L+ L +++I ++LF+A+IL+N
Sbjct 543 AFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNL 602
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP 746
D + Q A + + L R + P ++ ++S+ P
Sbjct 603 ELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMV-KISKLP 650
Score = 42.0 bits (97), Expect = 0.025, Method: Compositional matrix adjust.
Identities = 77/344 (22%), Positives = 136/344 (40%), Gaps = 90/344 (26%)
Query 387 GSVLLSAEE--FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALA 444
G+ LL+ ++ ++ L + L + PPRP+ F + H +F L+ LA
Sbjct 1164 GTALLTVDQRRWEDLKSRLKIAQPLHLPPRPD-NDGFRAKMYDITQHPFFKRTIALLVLA 1222
Query 445 NLVSICV-FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV 503
V + V + V D +P L ++ VF ++LE+ +K+ A+ G+ N
Sbjct 1223 QSVLLSVKWDVEDPVTVP-------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNR 1275
Query 504 FDGLLT---VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
+D L+T VV +VL + L Y M+G +IVFRF I
Sbjct 1276 YDLLVTSLGVVWVVLHFALLNAYTY--------MMGAC-----------VIVFRFFSICG 1316
Query 561 SMKLMAVVASTVLGLVQNMRAF----GGILVVVYYVFAII--------GINLFRGVIVAL 608
+ ++ TV+ V ++F G L+++ Y FA + G N+ R +
Sbjct 1317 KHVTLKMLLLTVV--VSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSS 1374
Query 609 PG---------------NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
G N + P + ++ YWA + ++A AL
Sbjct 1375 AGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGAL---------- 1424
Query 654 NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+YF ++++ + I +NL +A+I+ENF
Sbjct 1425 ------------------MYFCSFYVIIAYIMLNLLVAIIVENF 1450
Score = 39.3 bits (90), Expect = 0.17, Method: Compositional matrix adjust.
Identities = 68/296 (23%), Positives = 126/296 (43%), Gaps = 52/296 (18%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL-RGYLS 498
+ A+ +++ +C+ + + P + ++ L+ + + Y EM+ K+ G+ +G S
Sbjct 44 ICAIISVIPVCMNTPMTFEHYPPLQ--YVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSS 101
Query 499 YPSN---VFDGLLTVVL---LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
Y + VFDG + L LVL++ +A ++V +S W M R+ LI+
Sbjct 102 YVKDRWCVFDGFMVFCLWVSLVLQVFEIA-----------DIVDQMSPWGMLRIPRPLIM 150
Query 553 FRFLRIIPSMKLMAVVASTVLGLV-QNMRAFGGILVVVYYVFAIIGINLFRG------VI 605
R RI +L + +L + + + L+ ++ I+G+ +F V
Sbjct 151 IRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVN 210
Query 606 VALPGN---SSLA-PANGSAP-------------CGSFEQL-----EYWANNFDDFAAAL 643
PGN +SLA P +P C E L E + F++ ++
Sbjct 211 DTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSI 270
Query 644 VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV--NLFLALILENF 697
T++ W VFL S P + YF L+ + W+ N+F+A+I+E F
Sbjct 271 FTVYEASSQEGW-VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF 325
>sp|Q96P56|CTSR2_HUMAN Cation channel sperm-associated protein
2 OS=Homo sapiens OX=9606 GN=CATSPER2 PE=1 SV=2
Length=530
Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust.
Identities = 59/226 (26%), Positives = 111/226 (49%), Gaps = 12/226 (5%)
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
P LT V +L+ + +L ++ F K+ W + VV ++SL+ V L V
Sbjct 141 PLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVT 200
Query 181 HEP-----LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+ LRI R+LR LL ++ + + +L M + +LL I +F + G+
Sbjct 201 GQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGV 260
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTT----ANNPDV-MIPAYSKNRAYAI 290
+F+ + QD E +F +LP SL ++ +L T A DV +P S+ + +I
Sbjct 261 YVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFS-SI 319
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRA 336
+FI++ ++GS+ +++ A++ + F+ + K L + RR + +A
Sbjct 320 YFILWLLLGSIIFRSIIVAMMVTNFQN-IRKELNEEMARREVQLKA 364
Score = 47.8 bits (112), Expect = 3e-04, Method: Compositional matrix adjust.
Identities = 49/201 (24%), Positives = 102/201 (51%), Gaps = 39/201 (19%)
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL--SLWDMTRMLNMLIVFRFLRII 559
NVFD ++T++ L+ E+ L VG+ S+W ++L + V R L+++
Sbjct 178 NVFDFVVTMLSLLPEVVVL--------------VGVTGQSVW--LQLLRICRVLRSLKLL 221
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
+ + ++ ++ +++M +L++ +Y+FA+ G+ +F + +P
Sbjct 222 AQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVF--------SEYTRSPR-- 271
Query 620 SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-DAYR--RYSGPWSKIYFVL 676
+ LEY F D +LVT++ L +++W L D ++ S +S IYF+L
Sbjct 272 -------QDLEYHVF-FSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFIL 323
Query 677 WWLVSSVIWVNLFLALILENF 697
W L+ S+I+ ++ +A+++ NF
Sbjct 324 WLLLGSIIFRSIIVAMMVTNF 344
>sp|Q7RTX7|CTSR4_HUMAN Cation channel sperm-associated protein
4 OS=Homo sapiens OX=9606 GN=CATSPER4 PE=1 SV=1
Length=472
Score = 47.4 bits (111), Expect = 4e-04, Method: Compositional matrix adjust.
Identities = 43/187 (23%), Positives = 93/187 (50%), Gaps = 21/187 (11%)
Query 144 GYLFGWAHFQKNLW-LLGYLVVLVVSLVDWTVSLSL-VCHEPLRIRRLLRPFFLLQNSSM 201
G+L G+ F K+ W +L +++V ++ L + +++ + LR RL+ ++
Sbjct 143 GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEP--- 199
Query 202 MKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPES 261
+ + ++ I S+P+MA++ +L+ + +F++FG+ LF +FQN+ +
Sbjct 200 LARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK---------HFQNIQVA 250
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAY------AIFFIVFTVIGSLFLMNLLTAIIYSQF 315
L +L + +T D+ ++ R Y AI+F +F IG+ +NL ++ +
Sbjct 251 LYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNL 310
Query 316 RGYLMKS 322
+MK+
Sbjct 311 E-QMMKA 316
>sp|Q6AXP6|CTSR2_RAT Cation channel sperm-associated protein 2
OS=Rattus norvegicus OX=10116 GN=Catsper2 PE=2 SV=1
Length=584
Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust.
Identities = 50/175 (29%), Positives = 87/175 (50%), Gaps = 30/175 (17%)
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA---VVASTVLGLVQNMRAFGGILVV 588
PE V L+ + + L +L V R LR S+KL A + +L LV+ +++ +L++
Sbjct 189 PEFVVLIGVSADSVWLQLLRVSRVLR---SLKLFARFPQIKVILLALVRALKSMTFLLML 245
Query 589 VY---YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
+ YVFA+ G+ F+ + E LEY F D +LVT
Sbjct 246 LLIFFYVFAVAGVYFFK-----------------EYSRSTIENLEY-NMFFSDLLNSLVT 287
Query 646 LWNLMVVNNW-QVFLDAYR--RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
++ L +++W V D ++ S +S IY +LW L+ S+I+ N+ +A+++ NF
Sbjct 288 VFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNF 342
>sp|A2A259|PK2L1_MOUSE Polycystin-2-like protein 1 OS=Mus musculus
OX=10090 GN=Pkd2l1 PE=1 SV=1
Length=760
Score = 43.5 bits (101), Expect = 0.008, Method: Compositional matrix adjust.
Identities = 45/156 (29%), Positives = 74/156 (47%), Gaps = 24/156 (15%)
Query 465 DDFILG--ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL--------- 513
D FI+G ++ CVFI YY++E +L++ LR YLS N+ D L V+LL
Sbjct 349 DFFIVGCEVVFCVFIFYYVVEEILEIHLHRLR-YLSSVWNILD--LVVILLSIVAVGFHI 405
Query 514 --VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV------FRFLRIIPSMKLM 565
LE++ L L P + L+ W T+ NM V + + I K M
Sbjct 406 FRTLEVNRLMGKLLQQPDTYADF-EFLAFW-QTQYNNMNAVNLFFAWIKIFKYISFNKTM 463
Query 566 AVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
++ST+ +++ F + +V++ +A +G LF
Sbjct 464 TQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLF 499
>sp|Q9P0L9|PK2L1_HUMAN Polycystin-2-like protein 1 OS=Homo sapiens
OX=9606 GN=PKD2L1 PE=1 SV=1
Length=805
Score = 43.5 bits (101), Expect = 0.009, Method: Compositional matrix adjust.
Identities = 45/156 (29%), Positives = 74/156 (47%), Gaps = 24/156 (15%)
Query 465 DDFILG--ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL--------- 513
D FI+G ++ CVFI YY++E +L++ LR YLS N+ D L V+LL
Sbjct 349 DFFIVGCEVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILD--LVVILLSIVAVGFHI 405
Query 514 --VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV------FRFLRIIPSMKLM 565
LE++ L L P + L+ W T+ NM V + + I K M
Sbjct 406 FRTLEVNRLMGKLLQQPNTYADFE-FLAFW-QTQYNNMNAVNLFFAWIKIFKYISFNKTM 463
Query 566 AVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
++ST+ +++ F + +V++ +A +G LF
Sbjct 464 TQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLF 499
>sp|Q01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN7A PE=1 SV=2
Length=1682
Score = 42.4 bits (98), Expect = 0.018, Method: Compositional matrix adjust.
Identities = 46/197 (23%), Positives = 85/197 (43%), Gaps = 30/197 (15%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y SN + L VV++V +S + R E+
Sbjct 974 IFTYIFILEMLLKWMAYGFKAYF---SNGWYRLDFVVVIVFCLSLIG-------KTREEL 1023
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L+S + R LR++ + M VV ++ + ++++ +F+
Sbjct 1024 KPLIS----------MKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFS 1073
Query 595 IIGINLFRGVIVAL--PGNSSLAPAN---GSAPCGS--FEQLEYWAN---NFDDFAAALV 644
I+G++LF G P + P++ + C S F + W N NFD+ +
Sbjct 1074 IMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFL 1133
Query 645 TLWNLMVVNNWQVFLDA 661
+L + N W +++
Sbjct 1134 SLLQVATFNGWITIMNS 1150
Score = 35.8 bits (81), Expect = 2.0, Method: Compositional matrix adjust.
Identities = 125/602 (21%), Positives = 250/602 (42%), Gaps = 101/602 (17%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
L E +++ +F ++ +K +G+ A+F + L ++VV+V L + + +
Sbjct 967 LLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLS--LIGKTREELK 1024
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKC-IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
PL + LRP +L MK ++ I+ +LP + + L I L +F++ G+ LFAG
Sbjct 1025 PLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWL-IFSIMGVDLFAGR 1083
Query 242 KQD--DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ D ER + + +S L+ N ++ N F +G
Sbjct 1084 FYECIDPTSGERFPSSEVMNKSRCESLLF-----NESMLWENAKMN---------FDNVG 1129
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
+ FL L A F G++ + +++ + + FEV M F P
Sbjct 1130 NGFLSLLQVA----TFNGWIT-IMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLP 1184
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
L +L V +D+ +K K++ GS + + +K + L + ++ E RP
Sbjct 1185 ---LSMLITVIIDNFNKH----KIKLGGSNIFITVKQRKQYRRL-KKLMYEDSQRP-VPR 1235
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + F+F N+I + + + +++D DV + L +N +F++
Sbjct 1236 PLNKLQGFIFDVVTSQAF-NVIVMVLICFQAIAMMIDTDVQSLQMS-IALYWINSIFVML 1293
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLL---TVVLLVLEISTLAVYRLPHPGWRPEMVG 536
Y +E +LK+ A Y + N+FD ++ ++ L L + T+ Y +P P +V
Sbjct 1294 YTMECILKLIAFRCF-YFTIAWNIFDFMVVIFSITGLCLPM-TVGSYLVP-----PSLVQ 1346
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
L+ L +R+++ML R+ K+ + ++ + + ++ +V +++A+
Sbjct 1347 LILL---SRIIHML------RLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVF 1397
Query 597 GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ 656
G+ F V N +NF+ F +++ L+ + + W
Sbjct 1398 GMYNFAYVKKEAGIND--------------------VSNFETFGNSMLCLFQVAIFAGWD 1437
Query 657 VFLDAYRRYSGPWSK-----------------------IYFVLWWLVSSVIWVNLFLALI 693
LDA ++ WS YFV + L+S +I VN+++ ++
Sbjct 1438 GMLDAI--FNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVV 1495
Query 694 LE 695
+E
Sbjct 1496 ME 1497
>sp|Q8NEC5|CTSR1_HUMAN Cation channel sperm-associated protein
1 OS=Homo sapiens OX=9606 GN=CATSPER1 PE=1 SV=3
Length=780
Score = 41.6 bits (96), Expect = 0.031, Method: Compositional matrix adjust.
Identities = 41/210 (20%), Positives = 88/210 (42%), Gaps = 43/210 (20%)
Query 464 RDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV---FDGLLTVVLLVLEISTL 520
R ++ L+ +F Y++E LLK+ ALGL + + +N+ + + L+++ +
Sbjct 475 RGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSF 534
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
A+Y SL+ + ++ L R +R++ + + V L Q++
Sbjct 535 AIYH-------------QSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLP 581
Query 581 AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFA 640
+ IL++++ + LF V+ AL S F +
Sbjct 582 SIAAILILMFTC-----LFLFSAVLRALFRKSD-------------------PKRFQNIF 617
Query 641 AALVTLWNLMVVNNWQ-VFLDAYRRYSGPW 669
+ TL+ L+ +++W +++D+ R G W
Sbjct 618 TTIFTLFTLLTLDDWSLIYMDS--RAQGAW 645
>sp|P50077|CCH1_YEAST Calcium-channel protein CCH1 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CCH1
PE=1 SV=1
Length=2039
Score = 41.6 bits (96), Expect = 0.039, Method: Compositional matrix adjust.
Identities = 53/222 (24%), Positives = 99/222 (45%), Gaps = 48/222 (22%)
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
+L+ PS V+D +++++ LV IS LAV ++G + W L++ + RF
Sbjct 831 FLTKPSYVYDFIISIITLV--ISCLAV---------EGVLGHMYAW-----LSIFHISRF 874
Query 556 LRIIPSMKLMAVVASTVLG---LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R+I S L + +L ++ N+ +F ++ AII F GVI
Sbjct 875 YRVIISFNLTKKLWKQILSNGVMIWNLSSF---YFFFTFLVAIIMAVYFEGVI------- 924
Query 613 SLAPAN-GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
P P G + + ++L+ + NW L A +++S S
Sbjct 925 --PPEEMADQPFGMYS-----------LPNSFLSLFIIGSTENWTDILYALQKHSPNISS 971
Query 672 -----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
++F++W+L+S+ + +N+F+ALI E+ K + + Q
Sbjct 972 TFFCSVFFIIWFLLSNSVILNIFIALISESMEVKEEEKRPQQ 1013
>sp|Q80W99|CTSR3_MOUSE Cation channel sperm-associated protein
3 OS=Mus musculus OX=10090 GN=Catsper3 PE=1 SV=2
Length=395
Score = 37.7 bits (86), Expect = 0.37, Method: Compositional matrix adjust.
Identities = 33/156 (21%), Positives = 69/156 (44%), Gaps = 30/156 (19%)
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY---YVFAIIGINLFRGVIVALPGNS 612
LRI+ + + + ++ + + + +L +++ +VFAI+G LF
Sbjct 151 LRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLF----------- 199
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
G G LE W N A+A TL++L V+ W + + S+
Sbjct 200 ------GVTDRGD---LENWGN----LASAFFTLFSLATVDGWTDLQEELDKRKFTVSRA 246
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
+ +L+ L++S I++N+F+ +++ +H D +
Sbjct 247 FTILFILLASFIFLNMFVGVMI---MHTEDSMKKFE 279
>sp|B1AYL1|SCN7A_MOUSE Sodium channel protein type 7 subunit alpha
OS=Mus musculus OX=10090 GN=Scn7a PE=1 SV=1
Length=1681
Score = 38.1 bits (87), Expect = 0.44, Method: Compositional matrix adjust.
Identities = 28/81 (35%), Positives = 46/81 (57%), Gaps = 6/81 (7%)
Query 446 LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
+++IC FL L+ + E +L + N VFI Y +EM+LK+ A+ GY N+FD
Sbjct 517 VLNIC-FLALEHFPMSEELRS-LLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFD 574
Query 506 GLLTVV----LLVLEISTLAV 522
+L V+ +L+ ++ LAV
Sbjct 575 SILVVLELTEILLADVEGLAV 595
Score = 35.8 bits (81), Expect = 2.0, Method: Compositional matrix adjust.
Identities = 126/611 (21%), Positives = 256/611 (42%), Gaps = 119/611 (19%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGW-AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
L E +++ +F ++ +K +G+ A F N + L ++VV+V L + +
Sbjct 967 LLEYADMIFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLS--LIGKTREDLN 1024
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKC-IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
PL + LR +L MK L+ I+ +LP ++ + L I L LF++ G+ LFAG
Sbjct 1025 PLTSIKFLRALRVLSQFERMKVVLRALIKTTLPTVSVFLVCLMIWL-LFSVIGVQLFAGK 1083
Query 242 KQD--DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ D ER F+ + +S L+ ++++ + + F +G
Sbjct 1084 FYECIDPTKGERFPVFEVMNKSQCEKLL--------------FNESMPWENAKLNFDNVG 1129
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
+ FL L A F G++ + +++ + + +FE M F P
Sbjct 1130 NGFLSLLQVA----TFNGWI-SIMNSAIDSVGVNMQPSFEYNLYMYSYFIIFVIFGLFLP 1184
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR---SVVKEHPPRPE 416
L +L V + + +KQ K++ GS + + +K + L + + V++ PRP
Sbjct 1185 ---LCMLIGVIIRNFNKQ----KIKQGGSNIFITVKQKKQYRALKKLLYADVQKPTPRPR 1237
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD------FILG 470
+ F + FD + + + N++ I + + A + ++D+ +
Sbjct 1238 NK----------FQGFLFDLVTHRVF--NVI-IILLICFQATTIMIQKDEQSPQMETAIF 1284
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL---TVVLLVLEISTLAVYRLPH 527
+N +F++ + LE +LK+ A Y + NV D ++ ++ L+L + T+ Y +P
Sbjct 1285 WMNSIFVMLFTLECILKLTAFRCH-YFTSAWNVHDFMVVIFSITGLLLPL-TIGQYFVP- 1341
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
P +V L+ L +R++++L R K+ + ++ + + ++
Sbjct 1342 ----PSLVQLILL---SRVIHIL------RPGKGPKVFHDLMLPLILALPALLNISLLIF 1388
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
+V +++AI G+ F V N +NF+ F ++++ L+
Sbjct 1389 LVMFIYAIFGMYNFAYVKKEAGIND--------------------VSNFETFGSSMLCLF 1428
Query 648 NLMVVNNWQVFLDAYRRYSGPWSKI-----------------------YFVLWWLVSSVI 684
+ + W LDA ++ WS YFV + L+S +I
Sbjct 1429 QVTTFSGWDGMLDAI--FNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLI 1486
Query 685 WVNLFLALILE 695
VN+++ LI+E
Sbjct 1487 IVNMYIVLIME 1497
Score = 35.4 bits (80), Expect = 2.4, Method: Compositional matrix adjust.
Identities = 49/229 (21%), Positives = 85/229 (37%), Gaps = 38/229 (17%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
I L L+ + D + + +L + +F ++LEMLLK A G + + S
Sbjct 940 IGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLLKWVAYGFKAFFSNN 999
Query 501 SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM-LNMLIVFRF---L 556
D ++ +V LSL TR LN L +F L
Sbjct 1000 WYKLDFMVVIVF------------------------CLSLIGKTREDLNPLTSIKFLRAL 1035
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL--PGNSSL 614
R++ + M VV ++ + + ++++ +F++IG+ LF G P
Sbjct 1036 RVLSQFERMKVVLRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGER 1095
Query 615 AP---ANGSAPCGS--FEQLEYWAN---NFDDFAAALVTLWNLMVVNNW 655
P + C F + W N NFD+ ++L + N W
Sbjct 1096 FPVFEVMNKSQCEKLLFNESMPWENAKLNFDNVGNGFLSLLQVATFNGW 1144
Score = 34.3 bits (77), Expect = 6.2, Method: Compositional matrix adjust.
Identities = 40/145 (28%), Positives = 71/145 (49%), Gaps = 32/145 (22%)
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGL-RGYLSYPSNVFDGL---LTVVLLVLEISTLA 521
++IL I N + +Y E+L+KV A G+ G S+ ++++ L +T+ L+ S L+
Sbjct 143 EWILAIENTLLGIY-AFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFSPLS 201
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
+ ML + FR L+IIP L + S V+ L Q ++
Sbjct 202 SFL---------------------MLKTIRTFRILKIIP---LNHGLQSIVMTLAQCLKK 237
Query 582 -FGGILVVVYY--VFAIIGINLFRG 603
FG I + +++ VF+++G+ LF G
Sbjct 238 LFGAIALALFFLAVFSLLGMGLFMG 262
>sp|F1LQQ7|SCN7A_RAT Sodium channel protein type 7 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn7a PE=1 SV=4
Length=1680
Score = 37.4 bits (85), Expect = 0.63, Method: Compositional matrix adjust.
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 9/105 (9%)
Query 425 AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM 484
A + H FD + + +++IC FL L+ + E +L I N VFI Y +EM
Sbjct 498 ADRIITHPLFDLF---LVICIILNIC-FLALEHFPMSEELMS-LLAIGNLVFIGIYTIEM 552
Query 485 LLKVFALGLRGYLSYPSNVFDGLLTVV----LLVLEISTLAVYRL 525
+LK+ A+ GY ++FD +L V+ +L+ +I + V+ L
Sbjct 553 ILKIIAMHPYGYFQISWHIFDSILVVLGLTEMLLADIEEITVFIL 597
Score = 37.0 bits (84), Expect = 0.98, Method: Compositional matrix adjust.
Identities = 60/271 (22%), Positives = 111/271 (41%), Gaps = 48/271 (18%)
Query 135 VFAADLSVKGYLFGW-AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+F ++ +K +G+ A+F N + L ++VV+V+ L + + PL + LR
Sbjct 977 IFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLS--LIGKTREDLNPLASIKFLRAL 1034
Query 194 FLLQNSSMMKKTLKC-IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD--DGQDRE 250
+L MK L+ I+ +LP ++ + L I L LF++ G+ LFAG + D E
Sbjct 1035 RVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWL-LFSVMGVFLFAGKFYECIDPTRGE 1093
Query 251 RLTYFQNLPESLTSLLVL-------------------------LTTAN------NPDV-- 277
R + F+ + +S LV + T N N +
Sbjct 1094 RFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDS 1153
Query 278 ----MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLG 333
M P++ + +FI+F V G + +L +I F +K +++F +
Sbjct 1154 VGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIF-ITVK 1212
Query 334 TRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
+ + L ++ P A +P+N Q
Sbjct 1213 QKKQYRALKKLLYADSQKPAA---RPRNKFQ 1240
Score = 35.8 bits (81), Expect = 1.9, Method: Compositional matrix adjust.
Identities = 52/247 (21%), Positives = 100/247 (40%), Gaps = 48/247 (19%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+F ++LEMLLK A G + Y S D ++ +VL
Sbjct 973 IFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVL---------------------- 1010
Query 535 VGLLSLWDMTRM-LNMLIVFRF---LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
LSL TR LN L +F LR++ + M VV ++ + + ++++
Sbjct 1011 --CLSLIGKTREDLNPLASIKFLRALRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIW 1068
Query 591 YVFAIIGINLFRG----VIVALPGNS-SLAPANGSAPCGS--FEQLEYWAN---NFDDFA 640
+F+++G+ LF G I G S+ + C + F + W N NFD+
Sbjct 1069 LLFSVMGVFLFAGKFYECIDPTRGERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVG 1128
Query 641 AALVTLWNLMVVNNWQVFLDAYRRYSGPWSK----------IYFVLWWLVSSVIWVNLFL 690
++L+ + N W +++ G + + YF+++ + + + + +
Sbjct 1129 NGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLI 1188
Query 691 ALILENF 697
+I+ NF
Sbjct 1189 GVIIRNF 1195
>sp|Q86XQ3|CTSR3_HUMAN Cation channel sperm-associated protein
3 OS=Homo sapiens OX=9606 GN=CATSPER3 PE=1 SV=1
Length=398
Score = 37.0 bits (84), Expect = 0.69, Method: Compositional matrix adjust.
Identities = 33/143 (23%), Positives = 63/143 (44%), Gaps = 30/143 (21%)
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
Y+FAI+G LF +P NG +N+ + AAA TL++L
Sbjct 189 YIFAILGFCLFG------------SPDNGDH------------DNWGNLAAAFFTLFSLA 224
Query 651 VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL---ENFLHKWDPRSHL 707
V+ W S+ + +++ L++S I++N+F+ +++ E+ + K++ L
Sbjct 225 TVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELML 284
Query 708 QP---LAGTPEATYQMTVELLFR 727
+ L G + Q E + R
Sbjct 285 EQQEMLMGEKQVILQRQQEEISR 307
>sp|Q3APT3|TRPD_CHLCH Anthranilate phosphoribosyltransferase OS=Chlorobium
chlorochromatii (strain CaD3) OX=340177 GN=trpD
PE=3 SV=1
Length=351
Score = 34.7 bits (78), Expect = 2.9, Method: Compositional matrix adjust.
Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 2/91 (2%)
Query 328 FRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYG 387
RR LG R F +L ++ Q VGV + L ++ V L + + A++ +
Sbjct 165 IRRELGIRTLFNMLGPLLNPAQVKRQLVGVFSEELSELYADVLLQTGARHALIVHASTEE 224
Query 388 SVLLSAEEFQ--KLFNELDRSVVKEHPPRPE 416
V+L E+++ VV++H RPE
Sbjct 225 GVILDEPSLNGTTFVTEIEKGVVRKHTLRPE 255
>sp|A1VD65|RSMA_NITV4 Ribosomal RNA small subunit methyltransferase
A OS=Nitratidesulfovibrio vulgaris (strain DP4) OX=391774
GN=rsmA PE=3 SV=1
Length=266
Score = 34.3 bits (77), Expect = 3.2, Method: Compositional matrix adjust.
Identities = 16/28 (57%), Positives = 17/28 (61%), Gaps = 0/28 (0%)
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLF 726
H W HL PLAGTPEA +T LLF
Sbjct 64 HHWAREHHLHPLAGTPEAQVVLTDALLF 91
>sp|O14234|CCH1_SCHPO Calcium-channel protein cch1 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=cch1
PE=3 SV=1
Length=1854
Score = 34.7 bits (78), Expect = 4.8, Method: Compositional matrix adjust.
Identities = 56/255 (22%), Positives = 109/255 (43%), Gaps = 52/255 (20%)
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F + +E +K+ A G YL N D + V L + + L + L +R
Sbjct 987 FATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLSRAFR 1046
Query 532 P-EMVGLLSLWDMT----RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
+ + +L L ++T RM + ++ F +I + AVV++T+L
Sbjct 1047 AFKALRVLRLINLTQTSQRMFHDALISGFFKIFSA----AVVSATLL------------- 1089
Query 587 VVVYYVFAIIGINLFRGVIVALPGNSSLAPAN-----GSAPCGSFE--QLEYWAN----N 635
FA+ N+F G++ + ++ L+ + S P ++E W+N +
Sbjct 1090 ----IPFALWAKNVFGGLLYSCNDDNVLSASQCVLEYASTP-NNWEVWAPRVWSNPPDYD 1144
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIW 685
FD F AL+ L+ + + W + + +G + ++FVL+ LVS +
Sbjct 1145 FDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYI 1204
Query 686 VNLFLALILENFLHK 700
+ LF+A+I+ N+ +
Sbjct 1205 LTLFIAIIISNYAER 1219
Score = 34.3 bits (77), Expect = 6.0, Method: Compositional matrix adjust.
Identities = 43/199 (22%), Positives = 90/199 (45%), Gaps = 37/199 (19%)
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
+ L+ +VL VL + TL LP P G LS++ + R ++R + +IP +
Sbjct 581 YTNLVDIVLAVLNLVTL----LPSIRKNPVAFGWLSIFAIAR------IYRCILLIPYTR 630
Query 564 LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPC 623
+A + + + N+ F LV+V ++ ++ + LF+ + P +G +
Sbjct 631 KIAKLLFSNFKQLLNLMLF---LVIVLFIASLCAVRLFQDL-----------PNDGDSDD 676
Query 624 GSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG----PW-SKIYFVLWW 678
+ +A ++ F + ++ ++ NW + A + W +F LW+
Sbjct 677 DAIS----FATTYESF----LYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWF 728
Query 679 LVSSVIWVNLFLALILENF 697
L S+ + +++F+A+I NF
Sbjct 729 LFSNNVVLSMFIAVIQVNF 747
>sp|A8XSV3|NBEA_CAEBR Putative neurobeachin homolog OS=Caenorhabditis
briggsae OX=6238 GN=sel-2 PE=3 SV=1
Length=2531
Score = 34.7 bits (78), Expect = 5.1, Method: Compositional matrix adjust.
Identities = 33/144 (23%), Positives = 63/144 (44%), Gaps = 20/144 (14%)
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD---GQDRERLTYFQNL-----PESLTSL 265
PE + +++I + T ++ + D+ +D+E T L ++L +
Sbjct 747 PENFATAEIVSIRSAILTFINRIIISSNSPDEEEKARDQEIHTLLNLLATVREDDNLYDV 806
Query 266 LVLLTT--ANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSL 323
L L+T A +P +MIPA KN+A I F + L + L + + R L +
Sbjct 807 LALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKT 866
Query 324 QTSLFRRRLGTRAAFEVLSSMVGE 347
++ +G++ F S++GE
Sbjct 867 ES------MGSQNLF----SLIGE 880
>sp|Q9DEI1|PRKDC_XENLA DNA-dependent protein kinase catalytic
subunit OS=Xenopus laevis OX=8355 GN=prkdc PE=2 SV=1
Length=4146
Score = 33.9 bits (76), Expect = 7.2, Method: Compositional matrix adjust.
Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query 109 ADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF-GW 149
D ++ EPP GLTE +V CL+ A D ++ G ++ GW
Sbjct 4101 GDKKHNRRTNEPPDGLTEETQVQCLIDQATDPNILGRVWKGW 4142
>sp|A9KIR8|NAGB_LACP7 Glucosamine-6-phosphate deaminase OS=Lachnoclostridium
phytofermentans (strain ATCC 700394 / DSM 18823
/ ISDg) OX=357809 GN=nagB PE=3 SV=1
Length=236
Score = 33.1 bits (74), Expect = 8.3, Method: Composition-based stats.
Identities = 17/39 (44%), Positives = 23/39 (59%), Gaps = 1/39 (3%)
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFD-DFAAAL 643
V L NS L A GS P G+++QL W N D DF++ +
Sbjct 24 VILKPNSVLGLATGSTPIGTYKQLIEWYNKGDIDFSSTI 62
>sp|Q19317|NBEA_CAEEL Putative neurobeachin homolog OS=Caenorhabditis
elegans OX=6239 GN=sel-2 PE=2 SV=3
Length=2507
Score = 33.9 bits (76), Expect = 8.8, Method: Compositional matrix adjust.
Identities = 34/144 (24%), Positives = 62/144 (43%), Gaps = 20/144 (14%)
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ---DRERLTYFQNL-----PESLTSL 265
PE + ++AI + T ++ A ++ + D+E T L ++L +
Sbjct 740 PENFATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLLNLLATVREDDNLYDV 799
Query 266 LVLLTT--ANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSL 323
L L+T A +P +MIPA KN+A I F + L + L + + R L +
Sbjct 800 LALVTRLLAEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKT 859
Query 324 QTSLFRRRLGTRAAFEVLSSMVGE 347
++ +G + F S++GE
Sbjct 860 ES------MGNQNLF----SLIGE 873
>sp|Q5Y4W4|TAG2X_AGEOR U2-agatoxin-Ao1x OS=Agelena orientalis
OX=293813 PE=2 SV=1
Length=68
Score = 30.4 bits (67), Expect = 9.5, Method: Composition-based stats.
Identities = 20/65 (31%), Positives = 31/65 (48%), Gaps = 9/65 (14%)
Query 579 MRAFGGILVVVYYVFAII-------GINLFRGVIVALPGNSSLAPANGSAPCGSF--EQL 629
MRA +L++ VF++I G+ LF G LP N P++G C ++L
Sbjct 1 MRAIISLLLISAMVFSMIEAVPLEEGLQLFEGERGCLPRNKFCNPSSGPRCCSGLTCKEL 60
Query 630 EYWAN 634
WA+
Sbjct 61 NIWAS 65
Lambda K H a alpha
0.327 0.141 0.440 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 84595262452
Results from round 2
Query= sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens
OX=9606 GN=TPCN2 PE=1 SV=2
Length=752
Score E
Sequences producing significant alignments: (Bits) Value
Sequences used in model and found again:
sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens O... 783 0.0
sp|Q8BWC0|TPC2_MOUSE Two pore channel protein 2 OS=Mus musculus O... 684 0.0
sp|A0JMD4|TPC2_DANRE Two pore channel protein 2 OS=Danio rerio OX... 627 0.0
sp|Q9ER60|SCN4A_MOUSE Sodium channel protein type 4 subunit alpha... 559 5e-178
sp|P15390|SCN4A_RAT Sodium channel protein type 4 subunit alpha O... 557 2e-177
sp|P0DMA5|SCNAA_ONYTO Sodium channel protein type 10 subunit alph... 553 4e-175
sp|P15389|SCN5A_RAT Sodium channel protein type 5 subunit alpha O... 550 1e-173
sp|O46669|SCNAA_CANLF Sodium channel protein type 10 subunit alph... 548 2e-173
sp|Q99250|SCN2A_HUMAN Sodium channel protein type 2 subunit alpha... 549 3e-173
sp|Q14524|SCN5A_HUMAN Sodium channel protein type 5 subunit alpha... 548 4e-173
sp|B1AWN6|SCN2A_MOUSE Sodium channel protein type 2 subunit alpha... 548 6e-173
sp|Q9JJV9|SCN5A_MOUSE Sodium channel protein type 5 subunit alpha... 548 7e-173
sp|P04775|SCN2A_RAT Sodium channel protein type 2 subunit alpha O... 548 7e-173
sp|Q9WTU3|SCN8A_MOUSE Sodium channel protein type 8 subunit alpha... 547 1e-172
sp|Q6QIY3|SCNAA_MOUSE Sodium channel protein type 10 subunit alph... 546 2e-172
sp|Q9UQD0|SCN8A_HUMAN Sodium channel protein type 8 subunit alpha... 546 2e-172
sp|O88420|SCN8A_RAT Sodium channel protein type 8 subunit alpha O... 546 2e-172
sp|Q62205|SCN9A_MOUSE Sodium channel protein type 9 subunit alpha... 544 1e-171
sp|O08562|SCN9A_RAT Sodium channel protein type 9 subunit alpha O... 543 3e-171
sp|Q2XVR3|SC4AA_DANRE Sodium channel protein type 4 subunit alpha... 540 6e-171
sp|P04774|SCN1A_RAT Sodium channel protein type 1 subunit alpha O... 542 1e-170
sp|A2APX8|SCN1A_MOUSE Sodium channel protein type 1 subunit alpha... 542 1e-170
sp|P35499|SCN4A_HUMAN Sodium channel protein type 4 subunit alpha... 538 2e-170
sp|Q9Y5Y9|SCNAA_HUMAN Sodium channel protein type 10 subunit alph... 537 2e-169
sp|Q28644|SCN9A_RABIT Sodium channel protein type 9 subunit alpha... 537 5e-169
sp|P35498|SCN1A_HUMAN Sodium channel protein type 1 subunit alpha... 537 7e-169
sp|Q2XVR5|SC4AA_TETNG Sodium channel protein type 4 subunit alpha... 535 7e-169
sp|P08104|SCN3A_RAT Sodium channel protein type 3 subunit alpha O... 535 1e-168
sp|A2ASI5|SCN3A_MOUSE Sodium channel protein type 3 subunit alpha... 533 5e-168
sp|Q28371|SCN4A_HORSE Sodium channel protein type 4 subunit alpha... 531 7e-168
sp|Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha... 533 2e-167
sp|Q9NY46|SCN3A_HUMAN Sodium channel protein type 3 subunit alpha... 531 7e-167
sp|Q62968|SCNAA_RAT Sodium channel protein type 10 subunit alpha ... 530 2e-166
sp|Q20JQ7|SC4AB_DANRE Sodium channel protein type 4 subunit alpha... 524 2e-165
sp|Q2XVR4|SC4AB_TETNG Sodium channel protein type 4 subunit alpha... 520 2e-164
sp|Q2XVR7|SC4AA_TAKRU Sodium channel protein type 4 subunit alpha... 523 3e-164
sp|Q2XVR6|SC4AB_TAKRU Sodium channel protein type 4 subunit alpha... 516 8e-163
sp|P02719|SCNA_ELEEL Sodium channel protein OS=Electrophorus elec... 508 4e-159
sp|Q9R053|SCNBA_MOUSE Sodium channel protein type 11 subunit alph... 495 1e-154
sp|O88457|SCNBA_RAT Sodium channel protein type 11 subunit alpha ... 490 6e-153
sp|P35500|SCNA_DROME Sodium channel protein para OS=Drosophila me... 479 2e-147
sp|Q9UI33|SCNBA_HUMAN Sodium channel protein type 11 subunit alph... 473 1e-146
sp|P15381|CAC1C_RABIT Voltage-dependent L-type calcium channel su... 449 9e-137
sp|Q99246|CAC1D_MOUSE Voltage-dependent L-type calcium channel su... 448 1e-136
sp|Q01815|CAC1C_MOUSE Voltage-dependent L-type calcium channel su... 447 3e-136
sp|O35505|CAC1C_CAVPO Voltage-dependent L-type calcium channel su... 446 7e-136
sp|Q01668|CAC1D_HUMAN Voltage-dependent L-type calcium channel su... 445 2e-135
sp|P27732|CAC1D_RAT Voltage-dependent L-type calcium channel subu... 442 3e-134
sp|P22002|CAC1C_RAT Voltage-dependent L-type calcium channel subu... 441 5e-134
sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabid... 415 2e-133
sp|O60840|CAC1F_HUMAN Voltage-dependent L-type calcium channel su... 434 1e-131
sp|Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel su... 434 1e-131
sp|O73700|CAC1D_CHICK Voltage-dependent L-type calcium channel su... 434 2e-131
sp|Q9W0Y8|SCN60_DROME Sodium channel protein 60E OS=Drosophila me... 431 3e-130
sp|Q99244|CAC1D_MESAU Voltage-dependent L-type calcium channel su... 424 2e-129
sp|Q9JIS7|CAC1F_MOUSE Voltage-dependent L-type calcium channel su... 427 2e-129
sp|Q02789|CAC1S_MOUSE Voltage-dependent L-type calcium channel su... 426 2e-129
sp|Q02485|CAC1S_RAT Voltage-dependent L-type calcium channel subu... 425 5e-129
sp|P07293|CAC1S_RABIT Voltage-dependent L-type calcium channel su... 420 4e-127
sp|Q13698|CAC1S_HUMAN Voltage-dependent L-type calcium channel su... 412 2e-124
sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nico... 388 4e-123
sp|Q24270|CAC1D_DROME Voltage-dependent calcium channel type D su... 399 3e-119
sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nico... 377 5e-119
sp|P22316|CAC1S_CYPCA Dihydropyridine-sensitive L-type skeletal m... 396 1e-118
sp|O57483|CAC1S_AQUCT Voltage-dependent L-type calcium channel su... 390 6e-117
sp|Q05152|CAC1B_RABIT Voltage-dependent N-type calcium channel su... 383 5e-114
sp|Q02294|CAC1B_RAT Voltage-dependent N-type calcium channel subu... 381 2e-113
sp|O55017|CAC1B_MOUSE Voltage-dependent N-type calcium channel su... 379 2e-112
sp|Q00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel su... 379 2e-112
sp|P56698|CAC1B_DIPOM Probable voltage-dependent N-type calcium c... 377 7e-112
sp|P97445|CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel ... 369 3e-109
sp|O00555|CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel ... 369 6e-109
sp|P27884|CAC1A_RABIT Voltage-dependent P/Q-type calcium channel ... 368 8e-109
sp|Q25452|CAC1M_MUSDO Muscle calcium channel subunit alpha-1 OS=M... 367 1e-108
sp|Q05973|SCN1_HETBL Sodium channel protein 1 brain OS=Heterololi... 357 1e-105
sp|P54282|CAC1A_RAT Voltage-dependent P/Q-type calcium channel su... 359 2e-105
sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus mu... 342 1e-104
sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Hordeu... 339 4e-104
sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus n... 340 4e-104
sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza ... 339 6e-104
sp|Q02343|CAC1E_RABIT Voltage-dependent R-type calcium channel su... 352 2e-103
sp|C9D7C2|CAC1A_APIME Voltage-dependent calcium channel type A su... 352 2e-103
sp|P56699|CAC1E_DIPOM Probable voltage-dependent R-type calcium c... 352 2e-103
sp|Q61290|CAC1E_MOUSE Voltage-dependent R-type calcium channel su... 351 5e-103
sp|Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel su... 351 7e-103
sp|Q9ULQ1|TPC1_HUMAN Two pore channel protein 1 OS=Homo sapiens O... 336 2e-102
sp|Q07652|CAC1E_RAT Voltage-dependent R-type calcium channel subu... 349 5e-102
sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Tritic... 328 4e-100
sp|P91645|CAC1A_DROME Voltage-dependent calcium channel type A su... 328 4e-95
sp|D0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1 OS=Periplanet... 323 2e-93
sp|Q9P0X4|CAC1I_HUMAN Voltage-dependent T-type calcium channel su... 279 1e-78
sp|Q9Z0Y8|CAC1I_RAT Voltage-dependent T-type calcium channel subu... 278 3e-78
sp|O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel su... 278 4e-78
sp|O54898|CAC1G_RAT Voltage-dependent T-type calcium channel subu... 274 9e-77
sp|O43497|CAC1G_HUMAN Voltage-dependent T-type calcium channel su... 273 1e-76
sp|O88427|CAC1H_MOUSE Voltage-dependent T-type calcium channel su... 273 3e-76
sp|Q9EQ60|CAC1H_RAT Voltage-dependent T-type calcium channel subu... 271 6e-76
sp|O42398|CAC1S_CHICK Voltage-dependent L-type calcium channel su... 186 2e-52
sp|Q6Q760|NALCN_RAT Sodium leak channel NALCN OS=Rattus norvegicu... 181 5e-46
sp|Q8BXR5|NALCN_MOUSE Sodium leak channel NALCN OS=Mus musculus O... 181 6e-46
sp|Q8IZF0|NALCN_HUMAN Sodium leak channel NALCN OS=Homo sapiens O... 180 1e-45
sp|Q91ZR5|CTSR1_MOUSE Cation channel sperm-associated protein 1 O... 169 8e-43
sp|A2ARP9|CTSR2_MOUSE Cation channel sperm-associated protein 2 O... 151 3e-37
sp|Q6AXP6|CTSR2_RAT Cation channel sperm-associated protein 2 OS=... 146 2e-35
sp|Q7RTX7|CTSR4_HUMAN Cation channel sperm-associated protein 4 O... 134 4e-32
sp|Q8BVN3|CTSR4_MOUSE Cation channel sperm-associated protein 4 O... 132 7e-32
sp|Q96P56|CTSR2_HUMAN Cation channel sperm-associated protein 2 O... 131 7e-31
Sequences not found previously or not previously below threshold:
sp|B1AYL1|SCN7A_MOUSE Sodium channel protein type 7 subunit alpha... 342 6e-100
sp|Q01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha... 340 2e-99
sp|F1LQQ7|SCN7A_RAT Sodium channel protein type 7 subunit alpha O... 328 3e-95
sp|O14234|CCH1_SCHPO Calcium-channel protein cch1 OS=Schizosaccha... 161 2e-39
sp|Q8NEC5|CTSR1_HUMAN Cation channel sperm-associated protein 1 O... 134 3e-31
sp|P50077|CCH1_YEAST Calcium-channel protein CCH1 OS=Saccharomyce... 134 6e-31
sp|O73707|CAC1C_CHICK Voltage-dependent L-type calcium channel su... 112 3e-27
sp|O73705|CAC1A_CHICK Voltage-dependent P/Q-type calcium channel ... 99.8 5e-23
sp|O73706|CAC1B_CHICK Voltage-dependent N-type calcium channel su... 98.6 9e-23
sp|Q86XQ3|CTSR3_HUMAN Cation channel sperm-associated protein 3 O... 93.6 5e-19
sp|Q80W99|CTSR3_MOUSE Cation channel sperm-associated protein 3 O... 90.6 5e-18
sp|H2LRU7|PKD2_ORYLA Polycystin-2 OS=Oryzias latipes OX=8090 GN=p... 83.6 3e-15
sp|Q6IVV8|PKD2_DANRE Polycystin-2 OS=Danio rerio OX=7955 GN=pkd2 ... 77.5 3e-13
sp|A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger OS=S... 68.6 2e-10
sp|P17970|KCNAB_DROME Potassium voltage-gated channel protein Sha... 68.6 2e-10
sp|Q17ST2|KCNA7_MOUSE Potassium voltage-gated channel subfamily A... 67.1 3e-10
sp|Q96RP8|KCNA7_HUMAN Potassium voltage-gated channel subfamily A... 62.1 1e-08
sp|Q9TT17|KCNS3_RABIT Potassium voltage-gated channel subfamily S... 62.1 1e-08
sp|O88759|KCNS3_RAT Potassium voltage-gated channel subfamily S m... 61.3 2e-08
sp|A4K2S2|KCNS1_LEMCA Potassium voltage-gated channel subfamily S... 61.3 2e-08
sp|Q8BQZ8|KCNS3_MOUSE Potassium voltage-gated channel subfamily S... 60.9 3e-08
sp|Q4G0N8|SL9C1_HUMAN Solute carrier family 9 member C1 OS=Homo s... 61.3 3e-08
sp|Q7TSH7|KCNF1_MOUSE Voltage-gated potassium channel regulatory ... 60.5 3e-08
sp|D4ADX7|KCNF1_RAT Voltage-gated potassium channel regulatory su... 60.5 3e-08
sp|Q9H3M0|KCNF1_HUMAN Voltage-gated potassium channel regulatory ... 60.1 4e-08
sp|Q8CFS6|KCNV2_MOUSE Potassium voltage-gated channel subfamily V... 60.1 4e-08
sp|Q9BQ31|KCNS3_HUMAN Potassium voltage-gated channel subfamily S... 60.1 4e-08
sp|P15387|KCNB1_RAT Potassium voltage-gated channel subfamily B m... 60.1 7e-08
sp|Q03717|KCNB1_MOUSE Potassium voltage-gated channel subfamily B... 59.7 8e-08
sp|Q14721|KCNB1_HUMAN Potassium voltage-gated channel subfamily B... 59.7 9e-08
sp|Q4ZHA6|KCNB2_BOVIN Potassium voltage-gated channel subfamily B... 59.7 9e-08
sp|P79197|KCNA5_MUSPF Potassium voltage-gated channel subfamily A... 59.4 9e-08
sp|Q95L11|KCNB2_RABIT Potassium voltage-gated channel subfamily B... 59.4 1e-07
sp|Q92953|KCNB2_HUMAN Potassium voltage-gated channel subfamily B... 59.4 1e-07
sp|O18868|KCNB1_PIG Potassium voltage-gated channel subfamily B m... 59.0 1e-07
sp|A4K2Y2|KCNS1_CHLAE Potassium voltage-gated channel subfamily S... 58.2 2e-07
sp|Q9MZ19|KCNB1_RABIT Potassium voltage-gated channel subfamily B... 58.6 2e-07
sp|A4K2T1|KCNS1_MACMU Potassium voltage-gated channel subfamily S... 58.2 2e-07
sp|A4K2M4|KCNS1_PAPAN Potassium voltage-gated channel subfamily S... 57.8 2e-07
sp|P59994|KCND1_RABIT A-type voltage-gated potassium channel KCND... 58.2 2e-07
sp|A4K2P6|KCNS1_COLGU Potassium voltage-gated channel subfamily S... 57.8 3e-07
sp|Q63099|KCNB2_RAT Potassium voltage-gated channel subfamily B m... 57.8 3e-07
sp|P50638|KCNA5_RABIT Potassium voltage-gated channel subfamily A... 57.4 3e-07
sp|A4K2Q6|KCNS1_OTOGA Potassium voltage-gated channel subfamily S... 57.0 4e-07
sp|P22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily A... 57.4 4e-07
sp|P22460|KCNA5_HUMAN Potassium voltage-gated channel subfamily A... 57.0 4e-07
sp|Q52PG9|KCND1_BOVIN A-type voltage-gated potassium channel KCND... 57.0 5e-07
sp|A6H8H5|KCNB2_MOUSE Potassium voltage-gated channel subfamily B... 57.0 5e-07
sp|Q61762|KCNA5_MOUSE Potassium voltage-gated channel subfamily A... 56.7 6e-07
sp|P08510|KCNAS_DROME Potassium voltage-gated channel protein Sha... 56.7 7e-07
sp|P48994|TRPL_DROME Transient-receptor-potential-like protein OS... 56.7 8e-07
sp|A4K2R3|KCNS1_GORGO Potassium voltage-gated channel subfamily S... 56.3 8e-07
sp|P19024|KCNA5_RAT Potassium voltage-gated channel subfamily A m... 56.3 9e-07
sp|Q96KK3|KCNS1_HUMAN Potassium voltage-gated channel subfamily S... 55.9 9e-07
sp|A4K2N8|KCNS1_PANTR Potassium voltage-gated channel subfamily S... 55.9 9e-07
sp|A4K2V2|KCNS1_PONAB Potassium voltage-gated channel subfamily S... 55.9 9e-07
sp|Q4GZT3|PKD2_BOVIN Polycystin-2 OS=Bos taurus OX=9913 GN=PKD2 P... 56.3 1e-06
sp|Q05037|KCNA4_BOVIN Potassium voltage-gated channel subfamily A... 55.9 1e-06
sp|O35173|KCNS1_MOUSE Potassium voltage-gated channel subfamily S... 55.5 1e-06
sp|P10499|KCNA1_RAT Potassium voltage-gated channel subfamily A m... 55.5 1e-06
sp|P16388|KCNA1_MOUSE Potassium voltage-gated channel subfamily A... 55.5 1e-06
sp|Q09470|KCNA1_HUMAN Potassium voltage-gated channel subfamily A... 55.5 1e-06
sp|A2A259|PK2L1_MOUSE Polycystin-2-like protein 1 OS=Mus musculus... 55.5 1e-06
sp|P15384|KCNA3_RAT Potassium voltage-gated channel subfamily A m... 55.5 1e-06
sp|Q5F4C0|HVCN1_CHICK Voltage-gated hydrogen channel 1 OS=Gallus ... 53.6 1e-06
sp|Q6DHQ1|HVCN1_DANRE Voltage-gated hydrogen channel 1 OS=Danio r... 53.6 1e-06
sp|P16390|KCNA3_MOUSE Potassium voltage-gated channel subfamily A... 55.1 1e-06
sp|Q9ULS6|KCNS2_HUMAN Potassium voltage-gated channel subfamily S... 55.1 2e-06
sp|Q9Z0V1|KCND3_MOUSE A-type voltage-gated potassium channel KCND... 55.5 2e-06
sp|O35174|KCNS2_MOUSE Potassium voltage-gated channel subfamily S... 54.7 2e-06
sp|Q9ER26|KCNS2_RAT Potassium voltage-gated channel subfamily S m... 54.7 2e-06
sp|Q9NSA2|KCND1_HUMAN A-type voltage-gated potassium channel KCND... 55.1 2e-06
sp|O88758|KCNS1_RAT Potassium voltage-gated channel subfamily S m... 54.7 2e-06
sp|Q8TDN2|KCNV2_HUMAN Potassium voltage-gated channel subfamily V... 54.7 2e-06
sp|A4K2X4|KCNS1_SAIBB Potassium voltage-gated channel subfamily S... 54.7 2e-06
sp|A4K2W6|KCNS1_AOTNA Potassium voltage-gated channel subfamily S... 54.7 2e-06
sp|Q9P0L9|PK2L1_HUMAN Polycystin-2-like protein 1 OS=Homo sapiens... 54.7 3e-06
sp|P16389|KCNA2_HUMAN Potassium voltage-gated channel subfamily A... 54.0 4e-06
sp|Q9UK17|KCND3_HUMAN A-type voltage-gated potassium channel KCND... 54.0 4e-06
sp|Q9TTT5|KCND3_RABIT A-type voltage-gated potassium channel KCND... 54.0 4e-06
sp|Q9I830|KCNA2_ONCMY Potassium voltage-gated channel subfamily A... 54.0 4e-06
sp|Q9JK97|KCNQ4_MOUSE Potassium voltage-gated channel subfamily K... 54.0 4e-06
sp|Q28293|KCNA2_CANLF Potassium voltage-gated channel subfamily A... 53.6 4e-06
sp|Q5M8L8|HVCN1_XENTR Voltage-gated hydrogen channel 1 OS=Xenopus... 52.0 4e-06
sp|Q09081|KCNA2_RABIT Potassium voltage-gated channel subfamily A... 53.6 5e-06
sp|P17659|KCNA6_RAT Potassium voltage-gated channel subfamily A m... 53.6 5e-06
sp|P63142|KCNA2_RAT Potassium voltage-gated channel subfamily A m... 53.6 5e-06
sp|P63141|KCNA2_MOUSE Potassium voltage-gated channel subfamily A... 53.6 5e-06
sp|P56696|KCNQ4_HUMAN Potassium voltage-gated channel subfamily K... 53.6 6e-06
sp|Q9XXD1|KVS4_CAEEL Probable voltage-gated potassium channel sub... 53.2 6e-06
sp|P22459|KCNA4_HUMAN Potassium voltage-gated channel subfamily A... 53.6 7e-06
sp|P15385|KCNA4_RAT Potassium voltage-gated channel subfamily A m... 53.2 7e-06
sp|Q61923|KCNA6_MOUSE Potassium voltage-gated channel subfamily A... 53.2 7e-06
sp|Q28527|KCNA4_MUSPF Potassium voltage-gated channel subfamily A... 53.2 7e-06
sp|Q62897|KCND3_RAT A-type voltage-gated potassium channel KCND3 ... 53.2 7e-06
sp|Q7T199|KCA10_CHICK Potassium voltage-gated channel subfamily A... 52.8 8e-06
sp|Q5TAH2|SL9C2_HUMAN Sodium/hydrogen exchanger 11 OS=Homo sapien... 53.2 8e-06
sp|P22739|KCNA2_XENLA Potassium voltage-gated channel subfamily A... 52.8 8e-06
sp|Q03719|KCND1_MOUSE A-type voltage-gated potassium channel KCND... 53.2 9e-06
sp|Q96D96|HVCN1_HUMAN Voltage-gated hydrogen channel 1 OS=Homo sa... 51.6 9e-06
sp|Q61423|KCNA4_MOUSE Potassium voltage-gated channel subfamily A... 52.8 9e-06
sp|Q95167|KCNB2_CANLF Potassium voltage-gated channel subfamily B... 52.8 1e-05
sp|P25122|KCNC1_RAT Voltage-gated potassium channel KCNC1 OS=Ratt... 52.0 2e-05
sp|O35245|PKD2_MOUSE Polycystin-2 OS=Mus musculus OX=10090 GN=Pkd... 52.0 2e-05
sp|Q9Z351|KCNQ2_MOUSE Potassium voltage-gated channel subfamily K... 52.0 2e-05
sp|P17658|KCNA6_HUMAN Potassium voltage-gated channel subfamily A... 51.6 2e-05
sp|O88943|KCNQ2_RAT Potassium voltage-gated channel subfamily KQT... 52.0 2e-05
sp|Q16322|KCA10_HUMAN Potassium voltage-gated channel subfamily A... 51.3 2e-05
sp|O43526|KCNQ2_HUMAN Potassium voltage-gated channel subfamily K... 51.6 3e-05
sp|P34586|TRPL_CAEEL Transient-receptor-potential-like protein OS... 51.6 3e-05
sp|Q13563|PKD2_HUMAN Polycystin-2 OS=Homo sapiens OX=9606 GN=PKD2... 51.3 3e-05
sp|B2RQA1|KCA10_MOUSE Potassium voltage-gated channel subfamily A... 50.9 4e-05
sp|Q9VJJ7|TRPG_DROME Transient receptor potential-gamma protein O... 50.9 4e-05
sp|P15388|KCNC1_MOUSE Voltage-gated potassium channel KCNC1 OS=Mu... 50.5 4e-05
sp|Q9MYS6|KCNQ1_RABIT Potassium voltage-gated channel subfamily K... 50.5 5e-05
sp|Q5M7E9|HVCN1_XENLA Voltage-gated hydrogen channel 1 OS=Xenopus... 49.0 5e-05
sp|Q8BZB3|TM266_MOUSE Transmembrane protein 266 OS=Mus musculus O... 50.5 5e-05
sp|P17971|KCNAL_DROME Potassium voltage-gated channel protein Sha... 50.5 5e-05
sp|Q8HYZ1|KCND2_MUSPF A-type voltage-gated potassium channel KCND... 50.5 5e-05
sp|P48547|KCNC1_HUMAN Voltage-gated potassium channel KCNC1 OS=Ho... 50.1 6e-05
sp|Q63881|KCND2_RAT A-type voltage-gated potassium channel KCND2 ... 50.5 6e-05
sp|Q9NZV8|KCND2_HUMAN A-type voltage-gated potassium channel KCND... 50.5 6e-05
sp|O70344|KCNQ1_CAVPO Potassium voltage-gated channel subfamily K... 50.5 6e-05
sp|Q9Z0V2|KCND2_MOUSE A-type voltage-gated potassium channel KCND... 50.1 6e-05
sp|P59995|KCND2_RABIT A-type voltage-gated potassium channel KCND... 50.1 6e-05
sp|Q3U2S8|HVCN1_MOUSE Voltage-gated hydrogen channel 1 OS=Mus mus... 48.6 8e-05
sp|P97414|KCNQ1_MOUSE Potassium voltage-gated channel subfamily K... 49.7 9e-05
sp|Q9N0B5|TM266_MACFA Transmembrane protein 266 OS=Macaca fascicu... 49.3 1e-04
sp|P70057|KCNQ1_XENLA Potassium voltage-gated channel subfamily K... 49.3 1e-04
sp|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation cha... 49.3 1e-04
sp|Q2M3C6|TM266_HUMAN Transmembrane protein 266 OS=Homo sapiens O... 49.0 1e-04
sp|Q9Z0N7|KCNQ1_RAT Potassium voltage-gated channel subfamily KQT... 49.0 1e-04
sp|O97531|KCNQ1_FELCA Potassium voltage-gated channel subfamily K... 49.0 2e-04
sp|P51787|KCNQ1_HUMAN Potassium voltage-gated channel subfamily K... 49.0 2e-04
sp|Q96PR1|KCNC2_HUMAN Voltage-gated potassium channel KCNC2 OS=Ho... 49.0 2e-04
sp|Q63959|KCNC3_MOUSE Voltage-gated potassium channel KCNC3 OS=Mu... 49.0 2e-04
sp|P22462|KCNC2_RAT Voltage-gated potassium channel KCNC2 OS=Ratt... 48.6 2e-04
sp|Q14B80|KCNC2_MOUSE Voltage-gated potassium channel KCNC2 OS=Mu... 48.6 2e-04
sp|Q9TTJ7|KCNQ1_PIG Potassium voltage-gated channel subfamily KQT... 48.6 2e-04
sp|Q14003|KCNC3_HUMAN Voltage-gated potassium channel KCNC3 OS=Ho... 48.6 2e-04
sp|O73925|KCNQ1_SQUAC Potassium voltage-gated channel subfamily K... 48.6 2e-04
sp|Q01956|KCNC3_RAT Voltage-gated potassium channel KCNC3 OS=Ratt... 48.2 3e-04
sp|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation channel... 47.8 4e-04
sp|O73606|KCNG2_CHICK Voltage-gated potassium channel regulatory ... 47.4 4e-04
sp|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel ... 47.8 4e-04
sp|Q9U1S7|PKD2_CAEEL Polycystin-2 OS=Caenorhabditis elegans OX=62... 46.6 8e-04
sp|Q03721|KCNC4_HUMAN Voltage-gated potassium channel KCNC4 OS=Ho... 46.3 0.001
sp|Q9JK45|KCNQ5_MOUSE Potassium voltage-gated channel subfamily K... 45.9 0.001
sp|Q9QX29|TRPC5_MOUSE Short transient receptor potential channel ... 45.9 0.001
sp|O62852|TRPC5_RABIT Short transient receptor potential channel ... 45.9 0.002
sp|Q8R1C0|KCNC4_MOUSE Voltage-gated potassium channel KCNC4 OS=Mu... 45.5 0.002
sp|Q63734|KCNC4_RAT Voltage-gated potassium channel KCNC4 OS=Ratt... 45.5 0.002
sp|Q9UL62|TRPC5_HUMAN Short transient receptor potential channel ... 45.9 0.002
sp|O35119|TRPC4_RAT Short transient receptor potential channel 4 ... 45.9 0.002
sp|Q9NR82|KCNQ5_HUMAN Potassium voltage-gated channel subfamily K... 45.9 0.002
sp|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel s... 45.9 0.002
sp|Q9Y0A1|ITPR_CAEEL Inositol 1,4,5-trisphosphate receptor itr-1 ... 45.5 0.002
sp|P79100|TRPC4_BOVIN Short transient receptor potential channel ... 45.5 0.002
sp|P56180|TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE O... 45.1 0.002
sp|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channel ... 45.1 0.003
sp|A7T1N0|TMP2L_NEMVE Transient receptor potential cation channel... 45.1 0.003
sp|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channel ... 45.1 0.003
sp|P19334|TRP_DROME Transient receptor potential protein OS=Droso... 45.1 0.003
sp|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation channel... 44.3 0.004
sp|Q8TDN1|KCNG4_HUMAN Voltage-gated potassium channel regulatory ... 43.9 0.005
sp|Q5A2J7|YVC1_CANAL Calcium channel YVC1 OS=Candida albicans (st... 43.9 0.006
sp|Q2EG98|PK1L3_MOUSE Polycystin-1-like protein 3 OS=Mus musculus... 43.9 0.007
sp|Q7Z442|PK1L2_HUMAN Polycystin-1-like protein 2 OS=Homo sapiens... 43.9 0.008
sp|Q12324|YVC1_YEAST Calcium channel YVC1 OS=Saccharomyces cerevi... 43.2 0.010
sp|Q9UIX4|KCNG1_HUMAN Voltage-gated potassium channel regulatory ... 42.0 0.017
sp|Q9NTG1|PKDRE_HUMAN Polycystin family receptor for egg jelly OS... 42.0 0.026
sp|D4AD53|KCNG1_RAT Voltage-gated potassium channel regulatory su... 41.6 0.027
sp|Q28265|KCMA1_CANLF Calcium-activated potassium channel subunit... 41.6 0.035
sp|A2BDX4|KCNG1_MOUSE Voltage-gated potassium channel regulatory ... 40.9 0.039
sp|Q7TN88|PK1L2_MOUSE Polycystin-1-like protein 2 OS=Mus musculus... 41.2 0.041
sp|Q8R4F0|MCLN3_MOUSE Mucolipin-3 OS=Mus musculus OX=10090 GN=Mco... 40.9 0.047
sp|Q80XM3|KCNG4_MOUSE Voltage-gated potassium channel regulatory ... 40.5 0.061
sp|P59053|KCNG3_MOUSE Voltage-gated potassium channel regulatory ... 40.1 0.071
sp|Q61143|TRPC6_MOUSE Short transient receptor potential channel ... 40.1 0.079
sp|Q9JLG4|PK2L2_MOUSE Polycystin-2-like protein 2 OS=Mus musculus... 40.1 0.082
sp|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channel ... 40.1 0.084
sp|Q9Y210|TRPC6_HUMAN Short transient receptor potential channel ... 40.1 0.091
sp|Q09624|PKD1_CAEEL Location of vulva defective 1 OS=Caenorhabdi... 40.1 0.10
sp|Q8R523|KCNG3_RAT Voltage-gated potassium channel regulatory su... 39.3 0.11
sp|P58126|KCNQ3_BOVIN Potassium voltage-gated channel subfamily K... 39.3 0.15
sp|Q12791|KCMA1_HUMAN Calcium-activated potassium channel subunit... 39.3 0.15
sp|Q62976|KCMA1_RAT Calcium-activated potassium channel subunit a... 39.3 0.16
sp|O18866|KCMA1_PIG Calcium-activated potassium channel subunit a... 39.3 0.17
sp|Q28204|KCMA1_BOVIN Calcium-activated potassium channel subunit... 39.3 0.17
sp|Q9BG98|KCMA1_RABIT Calcium-activated potassium channel subunit... 39.3 0.17
sp|O18867|KCMA1_MACMU Calcium-activated potassium channel subunit... 39.3 0.17
sp|Q08460|KCMA1_MOUSE Calcium-activated potassium channel subunit... 39.3 0.17
sp|Q8TAE7|KCNG3_HUMAN Voltage-gated potassium channel regulatory ... 38.6 0.20
sp|O88944|KCNQ3_RAT Potassium voltage-gated channel subfamily KQT... 38.6 0.29
sp|Q8K3F6|KCNQ3_MOUSE Potassium voltage-gated channel subfamily K... 38.6 0.29
sp|O43525|KCNQ3_HUMAN Potassium voltage-gated channel subfamily K... 38.2 0.32
sp|Q6XPS3|TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 3-... 38.2 0.35
sp|Q00357|TOXA_COCCA MFS-type transporter TOXA OS=Cochliobolus ca... 37.8 0.38
sp|Q8AYS8|KCMA1_CHICK Calcium-activated potassium channel subunit... 37.8 0.43
sp|Q0P583|KCNV1_BOVIN Potassium voltage-gated channel subfamily V... 37.0 0.62
sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation channel... 37.4 0.65
sp|Q9TU34|ITPR1_BOVIN Inositol 1,4,5-trisphosphate-gated calcium ... 37.4 0.69
sp|F1LMY4|RYR1_RAT Ryanodine receptor 1 OS=Rattus norvegicus OX=1... 37.4 0.74
sp|P17972|KCNAW_DROME Potassium voltage-gated channel protein Sha... 37.0 0.76
sp|Q8NET8|TRPV3_HUMAN Transient receptor potential cation channel... 37.0 0.86
sp|Q9NA13|IPLA_DICDI Inositol 1,4,5-trisphosphate receptor-like p... 37.0 0.92
sp|Q4R6N0|TPTE2_MACFA Phosphatidylinositol 3,4,5-trisphosphate 3-... 36.6 0.92
sp|E9PZQ0|RYR1_MOUSE Ryanodine receptor 1 OS=Mus musculus OX=1009... 37.0 0.93
sp|Q8K424|TRPV3_MOUSE Transient receptor potential cation channel... 36.6 0.94
sp|P11881|ITPR1_MOUSE Inositol 1,4,5-trisphosphate-gated calcium ... 37.0 0.99
sp|Q99J21|MCLN1_MOUSE Mucolipin-1 OS=Mus musculus OX=10090 GN=Mco... 36.6 1.00
sp|Q5RC10|KCNV1_PONAB Potassium voltage-gated channel subfamily V... 36.6 1.0
sp|Q9GKU7|KCNV1_MACFA Potassium voltage-gated channel subfamily V... 36.6 1.0
sp|Q6PIU1|KCNV1_HUMAN Potassium voltage-gated channel subfamily V... 36.6 1.0
sp|Q90ZC7|KCMA1_XENLA Calcium-activated potassium channel subunit... 36.6 1.0
sp|P21817|RYR1_HUMAN Ryanodine receptor 1 OS=Homo sapiens OX=9606... 37.0 1.0
sp|P16960|RYR1_PIG Ryanodine receptor 1 OS=Sus scrofa OX=9823 GN=... 37.0 1.0
sp|P29994|ITPR1_RAT Inositol 1,4,5-trisphosphate-gated calcium ch... 36.6 1.1
sp|P11716|RYR1_RABIT Ryanodine receptor 1 OS=Oryctolagus cuniculu... 36.6 1.2
sp|Q13507|TRPC3_HUMAN Short transient receptor potential channel ... 36.2 1.4
sp|Q14643|ITPR1_HUMAN Inositol 1,4,5-trisphosphate-gated calcium ... 36.2 1.6
sp|E9PTA2|TRPM2_RAT Transient receptor potential cation channel s... 35.9 1.7
sp|O94759|TRPM2_HUMAN Transient receptor potential cation channel... 35.9 1.7
sp|Q7Z020|TRPA1_DROME Transient receptor potential cation channel... 35.9 1.8
sp|Q8WSR4|ITPR_PATPE Inositol 1,4,5-trisphosphate receptor OS=Pat... 35.9 1.8
sp|Q8TDD5|MCLN3_HUMAN Mucolipin-3 OS=Homo sapiens OX=9606 GN=MCOL... 35.1 2.7
sp|Q9JMI9|TRPC3_RAT Short transient receptor potential channel 3 ... 35.1 2.8
sp|Q9I829|KCNA1_ONCMY Shaker-related potassium channel tsha2 OS=O... 35.1 2.9
sp|Q9QZC1|TRPC3_MOUSE Short transient receptor potential channel ... 35.1 2.9
sp|Q9Z0T6|PKDRE_MOUSE Polycystin family receptor for egg jelly OS... 35.1 3.4
sp|A3LTB7|ALG3_PICST Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-m... 34.7 3.4
sp|B7ZC96|KCMA1_DANRE Calcium-activated potassium channel subunit... 34.7 3.7
sp|A2AGL3|RYR3_MOUSE Ryanodine receptor 3 OS=Mus musculus OX=1009... 34.7 4.1
sp|Q15413|RYR3_HUMAN Ryanodine receptor 3 OS=Homo sapiens OX=9606... 34.7 4.2
sp|Q9TS33|RYR3_RABIT Ryanodine receptor 3 OS=Oryctolagus cuniculu... 34.7 4.3
sp|Q9NZM6|PK2L2_HUMAN Polycystin-2-like protein 2 OS=Homo sapiens... 34.3 4.4
sp|Q9W0T5|PYX_DROME Transient receptor potential channel pyrexia ... 34.7 4.5
sp|F6RG56|MCLN3_CALJA Mucolipin-3 OS=Callithrix jacchus OX=9483 G... 34.3 4.6
sp|Q55GH9|GEFW_DICDI Ras guanine nucleotide exchange factor W OS=... 34.7 4.7
sp|Q8BZN2|KCNV1_MOUSE Potassium voltage-gated channel subfamily V... 33.9 5.9
sp|P55297|MANB_PIRSP Mannan endo-1,4-beta-mannosidase B OS=Piromy... 33.9 5.9
sp|A0A3T0QHT2|PVHT_TALVA Varicidin biosynthesis cluster MFS-type ... 33.9 6.0
sp|P97557|KCNV1_RAT Potassium voltage-gated channel subfamily V m... 33.9 6.3
sp|Q60HE8|MCLN1_MACFA Mucolipin-1 OS=Macaca fascicularis OX=9541 ... 33.9 6.3
sp|Q9GZU1|MCLN1_HUMAN Mucolipin-1 OS=Homo sapiens OX=9606 GN=MCOL... 33.9 6.3
sp|Q8T2Q0|ZDHC6_DICDI Putative ZDHHC-type palmitoyltransferase 6 ... 33.9 7.3
sp|Q28558|MTR1L_SHEEP Melatonin-related receptor OS=Ovis aries OX... 33.9 7.3
sp|Q8R455|TRPM8_RAT Transient receptor potential cation channel s... 33.9 7.7
sp|Q8MMH3|ARMT1_PIMHY Damage-control phosphatase ARMT1 OS=Pimpla ... 33.5 7.8
sp|Q8R4D5|TRPM8_MOUSE Transient receptor potential cation channel... 33.9 7.9
sp|Q18600|ERP1B_CAEEL Putative endoplasmic reticulum metallopepti... 33.5 8.3
sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmi... 33.5 9.7
>sp|Q8NHX9|TPC2_HUMAN Two pore channel protein 2 OS=Homo sapiens
OX=9606 GN=TPCN2 PE=1 SV=2
Length=752
Score = 783 bits (2021), Expect = 0.0, Method: Composition-based stats.
Identities = 752/752 (100%), Positives = 752/752 (100%), Gaps = 0/752 (0%)
Query 1 MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60
MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR
Sbjct 1 MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYR 60
Query 61 SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP
Sbjct 61 SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC
Sbjct 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG
Sbjct 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS
Sbjct 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ
Sbjct 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP
Sbjct 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY
Sbjct 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL
Sbjct 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL
Sbjct 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD
Sbjct 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
Query 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM
Sbjct 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
Query 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752
TVELLFRDILEEPGEDELTERLSQHPHLWLCR
Sbjct 721 TVELLFRDILEEPGEDELTERLSQHPHLWLCR 752
>sp|Q8BWC0|TPC2_MOUSE Two pore channel protein 2 OS=Mus musculus
OX=10090 GN=Tpcn2 PE=1 SV=1
Length=731
Score = 684 bits (1765), Expect = 0.0, Method: Composition-based stats.
Identities = 548/747 (73%), Positives = 632/747 (85%), Gaps = 18/747 (2%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
AE +PLLG RG G QV GAAA +LCIDQAVVFIEDAI+YRSI HR
Sbjct 3 AEEQPLLGRDRGSG-------------QVHSGAAADQELCIDQAVVFIEDAIKYRSIYHR 49
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+DA S+WLYR YYSNVCQR L F IFLIL LAF+E PSS T TADVRYR+ PW+PPCGLT
Sbjct 50 MDAGSLWLYRWYYSNVCQRVLGFIIFLILILAFVEVPSSFTKTADVRYRSQPWQPPCGLT 109
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLR 185
E++E CLL F DLSVKGYL G A Q+NLWLL Y +VLVVS+VDW VSLSL C EPLR
Sbjct 110 ETIEAFCLLAFLVDLSVKGYLVGQAQLQQNLWLLAYFMVLVVSVVDWIVSLSLACEEPLR 169
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT+ GMLLF G++D+
Sbjct 170 MRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDE 229
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
QD+ERL YF+NLPE+LTSLLVLLTT+NNPDVMIPAY++NRA+A+FFIVFT+IGSLFLMN
Sbjct 230 AQDQERLAYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAFALFFIVFTLIGSLFLMN 289
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
LLTAIIY+QFRGYLMKSLQTSLFRRRLG RAA+EVL+S G G P+ VGV P+ L V
Sbjct 290 LLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPELVGVNPETFLPV 349
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
LQK QL+ +HKQA+M+KV+SY + A+EFQKLF+E+D+ + KE P +P+YQSPFLQ+A
Sbjct 350 LQKTQLNKTHKQAIMQKVQSYEGRPMLADEFQKLFDEVDKGLAKERPLKPQYQSPFLQTA 409
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
QF+F H+YFDYLGNL+AL NL+SICVFLVLD+D+LP ERDDF+LGIL+ +FI+YYLLE+L
Sbjct 410 QFIFSHHYFDYLGNLVALGNLLSICVFLVLDSDLLPGERDDFVLGILDYIFILYYLLELL 469
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
KVFALGL GYLSY SNVFDGLLT++LLV EI TLAVYRLPH GW+PE G LSLWDMTR
Sbjct 470 FKVFALGLPGYLSYHSNVFDGLLTIILLVSEICTLAVYRLPHSGWKPEQYGPLSLWDMTR 529
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++N LIVFRFLRIIP++K MA VA+T+LGL+ N+RAFGGILVV YYVFA+IGINLFRGVI
Sbjct 530 LMNTLIVFRFLRIIPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVI 589
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
V PGNSSL P N SA CGSFEQL YW NNFDDFAAAL+TLWN+MVVNNWQV L+AY+RY
Sbjct 590 VP-PGNSSLVPDNNSAVCGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAYKRY 648
Query 666 SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+GPWS +YFVLWWLVSSVIW+NLFLAL+LENFLH+WDP+ H Q L G T QM+VEL+
Sbjct 649 AGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLVG----TKQMSVELM 704
Query 726 FRDILEEPGEDELTERLSQHPHLWLCR 752
FRDILEEP E+EL E+L +HPHL LCR
Sbjct 705 FRDILEEPKEEELMEKLHKHPHLHLCR 731
>sp|A0JMD4|TPC2_DANRE Two pore channel protein 2 OS=Danio rerio
OX=7955 GN=tpcn2 PE=2 SV=1
Length=774
Score = 627 bits (1616), Expect = 0.0, Method: Composition-based stats.
Identities = 426/776 (55%), Positives = 561/776 (72%), Gaps = 37/776 (5%)
Query 7 ESEPLLGGA-RGGGGDWPAGL--------------------TTYRSIQVGPGAAARWDLC 45
E EPLL G+ G GD+ A T S V A A DL
Sbjct 2 EEEPLLAGSINQGSGDYGAHSESCLHYPDEHTPRSRRLSYSVTDDSCNVEEDADA--DLY 59
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSL 105
+ QAVVFIEDAI+YRSINHRVD+ S+ LYR YYSN+CQ L TI ++L LAFIE PSSL
Sbjct 60 VQQAVVFIEDAIKYRSINHRVDSGSLRLYRWYYSNLCQWGLGLTIAVVLALAFIERPSSL 119
Query 106 TSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVL 165
T T+D+R + PWEPPCG+TE +E++CL +F D++ KGYL GW F+ N WLL YL+V+
Sbjct 120 TYTSDIRVKPKPWEPPCGMTEGIEIVCLCIFILDVTAKGYLIGWEEFRMNKWLLAYLIVI 179
Query 166 VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
S++DW +S+S++C E LR+RRL+RPFFLLQNSS+MKKTLKCI+ +LPE+ASV LLLA+
Sbjct 180 TASVIDWMLSISMLCDENLRVRRLIRPFFLLQNSSLMKKTLKCIKRTLPEIASVILLLAL 239
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
H+CLFTM GML+FA D Q+ E TYF+NLP++L+SLLVLLTTANNPDVMIPAYS N
Sbjct 240 HICLFTMIGMLIFA-KSDDPKQNGEWQTYFRNLPKALSSLLVLLTTANNPDVMIPAYSLN 298
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
R Y+IFFI+F+V G+ LMNL+TAIIY+QFRGYL+ S+QTS+ RRRLG RAAFEVL
Sbjct 299 RGYSIFFILFSVFGTYLLMNLMTAIIYNQFRGYLLMSVQTSIIRRRLGIRAAFEVLCCP- 357
Query 346 GEGGAFPQAVG----VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
G G QA G V L+V+++V + S +QA+++ R + +S E+FQ+LFN
Sbjct 358 GRGHTSTQAEGHVERVAVSMFLKVMERVHMKSYCRQAIVKAARRFPDGFISGEDFQRLFN 417
Query 402 ELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLP 461
ELD+ VKEHPP+PEY S LQ Q+++ HYY LGN +ALAN++ IC LVL+A+
Sbjct 418 ELDKDFVKEHPPKPEYSSSGLQHIQYVYSHYYISVLGNAVALANVICICTVLVLNAEKSA 477
Query 462 AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
+E++ F + I+NC+FI+YYL+EMLLK+ A G +GYLSY +N+FDG LTV+LL ++I
Sbjct 478 SEKNYFYMEIINCIFILYYLIEMLLKIVAFGWKGYLSYRNNIFDGFLTVLLLAIQIVIFI 537
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
+++P+ P +++LW+M R++NMLIVFRFLRIIP +KLMAVVAST++ LV+N+RA
Sbjct 538 TFKIPYVDVDPVPRHVMALWEMIRLVNMLIVFRFLRIIPEIKLMAVVASTIVDLVKNLRA 597
Query 582 FGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG-------SAPCGSFEQLEYWAN 634
F GIL+VVYY+FA++GI LF+G I S ++ ++ S CG+FEQLEYW N
Sbjct 598 FAGILLVVYYMFAVLGIWLFQGAISPPSNMSLVSNSSLENITGPYSMECGTFEQLEYWPN 657
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFDDFA++L+ L+N+MVVNNW VF DAY RY+ WS +YFV+WWL SSV+WVNLF+ALIL
Sbjct 658 NFDDFASSLILLYNIMVVNNWHVFTDAYARYTTDWSLVYFVVWWLTSSVMWVNLFVALIL 717
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWL 750
ENF +KWD RS+ + YQ TV+L+F++ ++EP E+EL +L QHPHL L
Sbjct 718 ENFTYKWD-RSNGLSVEDVERIAYQSTVQLMFKEHVKEPTEEELLAQLHQHPHLHL 772
>sp|Q9ER60|SCN4A_MOUSE Sodium channel protein type 4 subunit alpha
OS=Mus musculus OX=10090 GN=Scn4a PE=1 SV=1
Length=1841
Score = 559 bits (1440), Expect = 5e-178, Method: Composition-based stats.
Identities = 130/708 (18%), Positives = 265/708 (37%), Gaps = 105/708 (15%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + + F + I S + D+ + E
Sbjct 1004 SQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RRVIRTILEY 1061
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD----WTVSLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VS++ W L +
Sbjct 1062 ADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKS 1121
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1122 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK-- 1179
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
++ + + + + N + Y+ + + + +G
Sbjct 1180 ----------FYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVG---- 1225
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ M + ++ R + +EV M F + L
Sbjct 1226 LGYLSLLQVATFKGW-MDIMYAAVDSREKEEQPDYEVNLYMYLY---FVIFIIFGSFFTL 1281
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P Q+
Sbjct 1282 NLFIGVIIDNFNQQ----KKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1337
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
FD ++ N+V+ ++++ D + D IL +N VFI+ +
Sbjct 1338 GMVYDFVTKQVFDISIMILICLNMVT----MMVETDDQSQLKVD-ILYNINMVFIIVFTG 1392
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK+FAL Y + N+FD V+++L I LA+ L + P + ++ L
Sbjct 1393 ECVLKMFALR-HYYFTIGWNIFDF----VVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1447
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L +V ++++I G++ F
Sbjct 1448 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGMSNF 1498
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1499 AYVKKESGIDDM--------------------FNFETFGNSIICLFEITTSAGWDGLLNP 1538
Query 660 -------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHK 700
D P + I +F + ++S +I VN+++A+ILENF
Sbjct 1539 ILNSGPPDCDPTLENPGTNIKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVA 1598
Query 701 WDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEPGE 735
+ S P+AT + L F D L+EP +
Sbjct 1599 TEESSEPLCEDDFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQEPLK 1646
Score = 140 bits (352), Expect = 1e-32, Method: Composition-based stats.
Identities = 64/444 (14%), Positives = 142/444 (32%), Gaps = 50/444 (11%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + + +L L+T ++ + Y IFF+V +GS +L+NL+ A
Sbjct 379 GYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILA 438
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + + +L + ++L +A + +
Sbjct 439 VVAMAYAEQN----EATLAEDQEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEEADGD 494
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR-SVVKEHPPRPEYQ------SPFL 422
S ++ G S + + ++ + P Y+
Sbjct 495 PTHSKDCNGSLDTSGEKGPPRPSCSAESAISDAMEELEEAHQKCPPWWYKCAHKVLIWNC 554
Query 423 QSAQFLFGHYYF----DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ F H D +L +V +F+ ++ E D +L + N VF
Sbjct 555 CAPWVKFKHIILLIVMDPFVDLGITICIVLNTLFMAME-HYPMTEHFDNVLSVGNLVFTG 613
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ A+ Y N+FD + + LV L
Sbjct 614 IFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVEL--------------------GL 653
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 654 ANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 713
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF S L W + DF + + ++ ++ +
Sbjct 714 QLFGKSYKECVC-----------KIASDCSLPRWHMH--DFFHSFLIVFRILCGEWIETM 760
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D F++ ++ +
Sbjct 761 WDCMEVAGQAMCLTVFLMVMVIGN 784
Score = 97.9 bits (242), Expect = 2e-19, Method: Composition-based stats.
Identities = 31/183 (17%), Positives = 64/183 (35%), Gaps = 16/183 (9%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
V + L +F + + I T + + W ++ VE ++
Sbjct 121 RRVAIKVLIHALFSMFIMITILTNCVFMTMS----NPPSW------SKDVEYTFTGIYTF 170
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ +K G+ F ++ W V +++ T + L LR R+LR
Sbjct 171 ESLIKMLARGFCIDDFTFLRDPWNWLDFSV--ITMAYVTEFVDLGNISALRTFRVLRALK 228
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ +K + + S+ +++ V +L L +F + G+ LF G +
Sbjct 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMN 288
Query 255 FQN 257
N
Sbjct 289 DTN 291
Score = 97.1 bits (240), Expect = 3e-19, Method: Composition-based stats.
Identities = 41/227 (18%), Positives = 90/227 (40%), Gaps = 13/227 (6%)
Query 85 TLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV----EVLCLLVFAADL 140
I LI+ F++ ++ + + A P ++V ++ +F A++
Sbjct 560 KFKHIILLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEM 619
Query 141 SVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSS 200
+K + + W + ++ +SLV+ ++ ++ LR RLLR F L ++
Sbjct 620 VLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLA-NVQGLSVLRSFRLLRVFKLAKSWP 678
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD-----GQDRERLTYF 255
+ +K I S+ + ++ L+LAI + +F + GM LF ++ +
Sbjct 679 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCSLPRWHM 738
Query 256 QNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ S + +L + M + F++ VIG+
Sbjct 739 HDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 784
Score = 92.5 bits (228), Expect = 8e-18, Method: Composition-based stats.
Identities = 52/318 (16%), Positives = 96/318 (30%), Gaps = 47/318 (15%)
Query 325 TSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR 384
++ +R + A + M E ++ L ++ +E +
Sbjct 26 AAIEQRAMEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPLIYGDPPPEVIG-VPLEDLD 84
Query 385 SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPF---LQSAQFLFGHYYFDYLGNLI 441
Y S + + N+ P SPF + A + H F +
Sbjct 85 PYYSDK----KTFIVLNKGKAIFRFSATPALYMLSPFSIVRRVAIKVLIHALFSMFIMIT 140
Query 442 ALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYL 497
L N CVF+ + ++ + F Y E L+K+ A G +L
Sbjct 141 ILTN----CVFMTMSNPPSWSKD-------VEYTFTGIYTFESLIKMLARGFCIDDFTFL 189
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
P N D + + V E L L V R L+
Sbjct 190 RDPWNWLDFSVITMAYVTEFVDL---------------------GNISALRTFRVLRALK 228
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
I + + + ++ V+ + + V VFA++G+ LF G + P
Sbjct 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV---RWPP 285
Query 618 NGSAPCGSFEQLEYWANN 635
+ ++ + W N
Sbjct 286 PMNDTNTTWYGNDTWYGN 303
Score = 69.0 bits (167), Expect = 1e-10, Method: Composition-based stats.
Identities = 26/128 (20%), Positives = 50/128 (39%), Gaps = 4/128 (3%)
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
G + Y ++D F+ A + L+ LM + W+ R +G I+FV
Sbjct 363 CPEGYECMKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFV 422
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGE 735
+ + S +NL LA++ + + + E +Q +E F+ EE +
Sbjct 423 VIIFLGSFYLINLILAVVAMAYAEQNEA---TLAEDQEKEEEFQQMLEK-FKKHQEELEK 478
Query 736 DELTERLS 743
+ + L
Sbjct 479 AKAAQALE 486
>sp|P15390|SCN4A_RAT Sodium channel protein type 4 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn4a PE=1 SV=1
Length=1840
Score = 557 bits (1435), Expect = 2e-177, Method: Composition-based stats.
Identities = 125/691 (18%), Positives = 261/691 (38%), Gaps = 94/691 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + + F + I S + D+ + E
Sbjct 1003 SQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RRVIRTILEY 1060
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD----WTVSLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VS++ W L +
Sbjct 1061 ADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKS 1120
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1121 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK-- 1178
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
++ + + + + N + Y+ + + + +G
Sbjct 1179 ----------FYYCVNTTTSERFDISVVNNKSESESLMYTGQVRWMNVKVNYDNVG---- 1224
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ M + ++ R + +EV M F + L
Sbjct 1225 LGYLSLLQVATFKGW-MDIMYAAVDSREKEEQPHYEVNLYMYLY---FVIFIIFGSFFTL 1280
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P Q+
Sbjct 1281 NLFIGVIIDNFNQQ----KKKFGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1336
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
FD ++ N+V+ ++++ D + D IL +N VFI+ +
Sbjct 1337 GMVYDFVTKQVFDISIMILICLNMVT----MMVETDDQSQLKVD-ILYNINMVFIIIFTG 1391
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK+FAL Y + N+FD V+++L I LA+ L + P + ++ L
Sbjct 1392 ECVLKMFALR-HYYFTIGWNIFDF----VVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1446
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L +V ++++I G++ F
Sbjct 1447 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGMSNF 1497
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1498 AYVKKESGIDDM--------------------FNFETFGNSIICLFEITTSAGWDGLLNP 1537
Query 660 -------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHK 700
D P + + +F + ++S +I VN+++A+ILENF
Sbjct 1538 ILNSGPPDCDPTLENPGTNVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVA 1597
Query 701 WDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ S +PL+ + T E D +
Sbjct 1598 TEESS--EPLSEDDFEMFYETWEKFDPDATQ 1626
Score = 145 bits (365), Expect = 3e-34, Method: Composition-based stats.
Identities = 63/443 (14%), Positives = 141/443 (32%), Gaps = 48/443 (11%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + + +L L+T ++ + Y IFF+V +GS +L+NL+ A
Sbjct 379 GYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILA 438
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + + +L + ++L +A + +
Sbjct 439 VVAMAYAEQN----EATLAEDQEKEEEFQQMLEKYKKHQEELEKAKAAQALESGEEADGD 494
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-----QSPFLQS 424
+ ++ G S + + ++ P + +
Sbjct 495 PTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPPWWYKCAHKVLIWNC 554
Query 425 AQFLFGHYYFDYLGNLIALANL-VSICVFL----VLDADVLPAERDDFILGILNCVFIVY 479
+ YL + +L ++IC+ L + E D +L + N VF
Sbjct 555 CAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGI 614
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM+LK+ A+ Y N+FD + + LV L+
Sbjct 615 FTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVEL--------------------GLA 654
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 655 NVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 714
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF S L W N DF + + ++ ++ +
Sbjct 715 LFGKSYKECVC-----------KIASDCNLPRWHMN--DFFHSFLIVFRILCGEWIETMW 761
Query 660 DAYRRYSGPWSKIYFVLWWLVSS 682
D F++ ++ +
Sbjct 762 DCMEVAGQAMCLTVFLMVMVIGN 784
Score = 98.3 bits (243), Expect = 1e-19, Method: Composition-based stats.
Identities = 30/183 (16%), Positives = 63/183 (34%), Gaps = 16/183 (9%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
V + L +F + + I T + ++ + VE ++
Sbjct 121 RRVAIKVLIHALFSMFIMITILTNCVFMTMSNPPSWSKH----------VEYTFTGIYTF 170
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ +K G+ F ++ W V +++ T + L LR R+LR
Sbjct 171 ESLIKMLARGFCIDDFTFLRDPWNWLDFSV--ITMAYVTEFVDLGNISALRTFRVLRALK 228
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ +K + + S+ +++ V +L L +F + G+ LF G +
Sbjct 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMN 288
Query 255 FQN 257
N
Sbjct 289 DTN 291
Score = 97.1 bits (240), Expect = 3e-19, Method: Composition-based stats.
Identities = 41/227 (18%), Positives = 91/227 (40%), Gaps = 13/227 (6%)
Query 85 TLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV----EVLCLLVFAADL 140
I+LI+ F++ ++ + + A P ++V ++ +F A++
Sbjct 560 KFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAEM 619
Query 141 SVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSS 200
+K + + W + ++ +SLV+ ++ ++ LR RLLR F L ++
Sbjct 620 VLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLA-NVQGLSVLRSFRLLRVFKLAKSWP 678
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD-----GQDRERLTYF 255
+ +K I S+ + ++ L+LAI + +F + GM LF ++ +
Sbjct 679 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCNLPRWHM 738
Query 256 QNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ S + +L + M + F++ VIG+
Sbjct 739 NDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 784
Score = 94.8 bits (234), Expect = 2e-18, Method: Composition-based stats.
Identities = 52/318 (16%), Positives = 97/318 (31%), Gaps = 47/318 (15%)
Query 325 TSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR 384
++ +R + A + M E ++ L ++ +E +
Sbjct 26 AAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPLIYGDPPPEVIG-IPLEDLD 84
Query 385 SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPF---LQSAQFLFGHYYFDYLGNLI 441
Y S + + N+ P SPF + A + H F +
Sbjct 85 PYYSDK----KTFIVLNKGKAIFRFSATPALYLLSPFSIVRRVAIKVLIHALFSMFIMIT 140
Query 442 ALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYL 497
L N CVF+ + ++ + F Y E L+K+ A G +L
Sbjct 141 ILTN----CVFMTMSNPPSWSKH-------VEYTFTGIYTFESLIKMLARGFCIDDFTFL 189
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
P N D + + V E L L V R L+
Sbjct 190 RDPWNWLDFSVITMAYVTEFVDL---------------------GNISALRTFRVLRALK 228
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
I + + + ++ V+ + + V VFA++G+ LF G + P
Sbjct 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV---RWPP 285
Query 618 NGSAPCGSFEQLEYWANN 635
+ ++ + W +N
Sbjct 286 PMNDTNTTWYGNDTWYSN 303
Score = 69.0 bits (167), Expect = 1e-10, Method: Composition-based stats.
Identities = 23/130 (18%), Positives = 46/130 (35%), Gaps = 8/130 (6%)
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
G + Y ++D F+ A + L+ LM + W+ R +G I+FV
Sbjct 363 CPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFV 422
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDP--------RSHLQPLAGTPEATYQMTVELLFR 727
+ + S +NL LA++ + + + Q + + + +
Sbjct 423 VIIFLGSFYLINLILAVVAMAYAEQNEATLAEDQEKEEEFQQMLEKYKKHQEELEKAKAA 482
Query 728 DILEEPGEDE 737
LE E +
Sbjct 483 QALESGEEAD 492
>sp|P0DMA5|SCNAA_ONYTO Sodium channel protein type 10 subunit
alpha OS=Onychomys torridus OX=38674 GN=Scn10a PE=1 SV=1
Length=1959
Score = 553 bits (1425), Expect = 4e-175, Method: Composition-based stats.
Identities = 125/693 (18%), Positives = 264/693 (38%), Gaps = 88/693 (13%)
Query 65 RVDASSM-WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCG 123
+V S W C R + + F + I S + D P
Sbjct 1129 KVSTSKFPWTTGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEQKPRVK--S 1186
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLV 179
+ E + + +F ++ +K +G+ + N W +++ +SL +
Sbjct 1187 MLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILDYSDVA 1246
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1247 SLKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1306
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
G R N P S+ + ++ N + ++N F++ V
Sbjct 1307 GKF-------SRCIDTSNNPFSVVNSTIV---NNKSECR----NQNHTGHFFWVNVKVNF 1352
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
M L + + F+G+ M + ++ R + ++ +E M F G
Sbjct 1353 DNVAMGYLALLQVATFKGW-MDIMYAAVDSREINSQPQWEDNLYMYLYFVVFIIFGG--- 1408
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQ 418
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1409 FFTLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPL 1464
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + + FD + ++ N+++ ++++ D E+ ILG +N F+
Sbjct 1465 NKYQGFVFDIVTRQAFDIIIMVLICLNMIT----MMVETDGQSEEKTK-ILGRINQFFVA 1519
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ E ++K+FAL + Y + NVFD + V+L + + A+ + + P + ++
Sbjct 1520 VFTGECVMKMFALR-QYYFTNGWNVFDF-IVVILSIGSLVFSAILKSLESYFSPTLFRVI 1577
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M + + G +L +V ++++I G+
Sbjct 1578 RLARIGRILRLIRAAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGM 1628
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
F V+ + NF F +++ L+ + W
Sbjct 1629 ASFANVVEEAGIDDM--------------------FNFQTFGNSMLCLFQITTSAGWDGL 1668
Query 659 LDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILENFL 698
L P+ ++F + ++S +I VN+++A+ILENF
Sbjct 1669 LSPILNTGPPYCDPNLSNNNTSKGNCGSPTVGIVFFTTYIIISFLIVVNMYIAVILENFN 1728
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + +PL+ + T E + +
Sbjct 1729 VATEEST--EPLSEDDFDMFYETWEKFDPEATQ 1759
Score = 230 bits (587), Expect = 5e-62, Method: Composition-based stats.
Identities = 63/342 (18%), Positives = 124/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + R +L + VF +
Sbjct 1143 VRKTCYRIVEHSWFESFIIFMILLSSGALAFE---DNYLEQKPRVKSMLEYTDRVFTFIF 1199
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+ EMLLK A G + Y + D L+ + L I+ + Y S
Sbjct 1200 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILDY---------------SD 1244
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV ++G + ++ + ++ + +F+I+G+NL
Sbjct 1245 VASLKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1304
Query 601 FRGVIVALPGNSS-------LAPANGSAPCGSFEQLEY--WAN---NFDDFAAALVTLWN 648
F G S+ N + C + + W N NFD+ A + L
Sbjct 1305 FAGKFSRCIDTSNNPFSVVNSTIVNNKSECRNQNHTGHFFWVNVKVNFDNVAMGYLALLQ 1364
Query 649 LMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A + +YFV++ + +NLF+ +I++NF
Sbjct 1365 VATFKGWMDIMYAAVDSREINSQPQWEDNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFN 1424
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1425 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1466
Score = 145 bits (366), Expect = 2e-34, Method: Composition-based stats.
Identities = 64/349 (18%), Positives = 120/349 (34%), Gaps = 77/349 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A + H +F + L N V + + + + F V
Sbjct 117 NLIRRTAIKVSVHAWFSIFITITILFNCVCM--------------TQNDLPEKIEYAFTV 162
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G YL P N D + + V L
Sbjct 163 IYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL-------------- 208
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ + + + V+ ++ V+ + + V VFA
Sbjct 209 -------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFA 261
Query 595 IIGINLFRGVIVALPGNSSLAPAN-----------------------------------G 619
++G+ LF+G + S P N G
Sbjct 262 LVGLQLFKGNLKNKCIKRSTDPHNAYNFSSQMADNFYIKNGTTEPLLCGNGSDAGHCPSG 321
Query 620 SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWL 679
+ + ++ +FD FA A ++L+ LM ++W+ R SG ++FVL
Sbjct 322 YICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIF 381
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
+ S VNL LA++ ++ ++ + + E +Q +E+L ++
Sbjct 382 LGSFYLVNLILAVV--TMAYEEQNQATIAEIEAK-EKKFQEALEVLQKE 427
Score = 120 bits (302), Expect = 1e-26, Method: Composition-based stats.
Identities = 42/265 (16%), Positives = 92/265 (35%), Gaps = 33/265 (12%)
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
D L +V +F+ ++ + D +L N VF V++ +EM K+ A
Sbjct 664 DPFAELTITLCIVVNTIFMAME-HYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPY 722
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y NVFD ++ V L+ ++ +L + R
Sbjct 723 YYFQKKWNVFDCVIVTVSLLEL--------------------SIAKKGSLSVLRTFRLLR 762
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
++ S + + + V + IL ++ ++FA++G L
Sbjct 763 VFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLG------------ 810
Query 615 APANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF 674
+ + DF + + ++ ++ + + I F
Sbjct 811 EDYGCRKDGTALWNEGQLRWHMCDFFHSFLVIFRILCGEWIENMWVCMQVSEKSICLILF 870
Query 675 VLWWLVSSVIWVNLFLALILENFLH 699
+ ++ +++ +NLF+AL+L +F
Sbjct 871 LTVMVLGNLVVLNLFIALLLNSFSA 895
Score = 114 bits (286), Expect = 1e-24, Method: Composition-based stats.
Identities = 50/347 (14%), Positives = 113/347 (33%), Gaps = 63/347 (18%)
Query 120 PPCGLTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVS 175
L E +E +++ + +K G+ + ++ W V ++L +
Sbjct 148 TQNDLPEKIEYAFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSV--ITLAYVGAA 205
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+ L LR R+LR + +K + + S+ ++A V +L L +F + G+
Sbjct 206 IDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGL 265
Query 236 LLFAGGKQDDGQDRE--------------------------------------------- 250
LF G ++ R
Sbjct 266 QLFKGNLKNKCIKRSTDPHNAYNFSSQMADNFYIKNGTTEPLLCGNGSDAGHCPSGYICL 325
Query 251 --------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS-KNRAYAIFFIVFTVIGSL 301
T F + + SL L+T + + + Y +FF++ +GS
Sbjct 326 KTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSF 385
Query 302 FLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQN 361
+L+NL+ A++ + ++ + + + A EVL + + +
Sbjct 386 YLVNLILAVVTMAYEEQNQATI-AEIEAKEKKFQEALEVL--QKEQEVLAALGIDTTSLH 442
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+++ ++ ++ S GS + +N+ S +
Sbjct 443 SHNGSPLAPKNANERKHRIKSRVSEGSTDDNRSPQSDPYNQRRMSFL 489
Score = 95.9 bits (237), Expect = 6e-19, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 86/203 (42%), Gaps = 10/203 (5%)
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
+ ++ ++ + F +++ K F ++ + W + V++ VSL++ +++
Sbjct 695 AMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNVFDCVIVTVSLLELSIA-KKGSLS 753
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR RLLR F L ++ + +K I S+ + ++ +LAI + +F + G L
Sbjct 754 VLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLGEDY 813
Query 243 QDDG------QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIV 294
+ + + + S + +L + M S+ I F+
Sbjct 814 GCRKDGTALWNEGQLRWHMCDFFHSFLVIFRILCGE-WIENMWVCMQVSEKSICLILFLT 872
Query 295 FTVIGSLFLMNLLTAIIYSQFRG 317
V+G+L ++NL A++ + F
Sbjct 873 VMVLGNLVVLNLFIALLLNSFSA 895
>sp|P15389|SCN5A_RAT Sodium channel protein type 5 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn5a PE=1 SV=1
Length=2019
Score = 550 bits (1416), Expect = 1e-173, Method: Composition-based stats.
Identities = 139/771 (18%), Positives = 274/771 (36%), Gaps = 108/771 (14%)
Query 3 EPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSI 62
EPQA G T ++ P D F E ++
Sbjct 1124 EPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDV---KDPEDCFTEGCVRRCPC 1180
Query 63 NHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC 122
S C R + + F + I S + D+ +
Sbjct 1181 CMVDTTQSPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDI--YLEERKTIK 1238
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LSL 178
L E + + VF ++ +K +G+ + N W +++ VSLV + +
Sbjct 1239 VLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEM 1298
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LF
Sbjct 1299 GPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1358
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANN-PDVMIPAYSKNRAYAIFFIVFTV 297
AG + + + ++ L + T NN + + + + F
Sbjct 1359 AGK------------FGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDN 1406
Query 298 IGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGV 357
+G+ +L L A F+G+ M + ++ R + +E M F
Sbjct 1407 VGAGYLALLQVA----TFKGW-MDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIF--- 1458
Query 358 KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPE 416
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1459 GSFFTLNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR 1514
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
+ + + FD + N+V+ ++++ D E+ + IL +N +F
Sbjct 1515 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVT----MMVETDDQSPEKVN-ILAKINLLF 1569
Query 477 IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-WRPEMV 535
+ + E ++K+ AL Y + N+FD V+++L I + + + P +
Sbjct 1570 VAIFTGECIVKMAALR-HYYFTNSWNIFDF----VVVILSIVGTVLSDIIQKYFFSPTLF 1624
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
++ L + R+L ++ + +R + +M + + G +L +V ++++I
Sbjct 1625 RVIRLARIGRILRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSI 1675
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
G+ F V + NF FA +++ L+ + W
Sbjct 1676 FGMANFAYVKWEAGIDDM--------------------FNFQTFANSMLCLFQITTSAGW 1715
Query 656 QVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILE 695
L P+ ++F + ++S +I VN+++A+ILE
Sbjct 1716 DGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1775
Query 696 NFLHKWDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
NF + + PEAT + L F D L EP
Sbjct 1776 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEP 1826
Score = 246 bits (628), Expect = 2e-67, Method: Composition-based stats.
Identities = 73/419 (17%), Positives = 147/419 (35%), Gaps = 51/419 (12%)
Query 350 AFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-------FQKLFNE 402
PQA G + D ++ ++E++ G + E+ +
Sbjct 1123 TEPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCM 1182
Query 403 LDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
+D + ++ + H +F+ + L + ++ D +
Sbjct 1183 VDTTQSPGKV-----WWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFE---DIYLEER 1234
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
+ +L + +F ++LEMLLK A G + Y + D L+ V LV ++
Sbjct 1235 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLG 1294
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
+ P + L L R LR + + M VV + ++G + ++
Sbjct 1295 FAEMGP---------------IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV 1339
Query 583 GGILVVVYYVFAIIGINLFRGVIVAL--------PGNSSLAPANGSAPCGSFEQLEYWAN 634
+ ++ + +F+I+G+NLF G P N ++ + YW
Sbjct 1340 LLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTK 1399
Query 635 ---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVS 681
NFD+ A + L + W + A G + IYFV++ +
Sbjct 1400 VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFG 1459
Query 682 SVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
S +NLF+ +I++NF + + Y ++ L ++P L +
Sbjct 1460 SFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1518
Score = 141 bits (356), Expect = 4e-33, Method: Composition-based stats.
Identities = 84/485 (17%), Positives = 158/485 (33%), Gaps = 97/485 (20%)
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
+ NLL S FR + +SL + +R+ + A ++ + +PQ
Sbjct 1 MANLLLPRGTSSFRRFTRESL--AAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLD 58
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------E 416
LQ +K+ + + + QK F L++
Sbjct 59 LQASKKLPDLYGNPPRELIGEPLEDLDPFYST--QKTFIVLNKGKTIFRFSATNALYVLS 116
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
P ++A + H F ++ + +++ CVF+ P ++ F
Sbjct 117 PFHPVRRAAVKILVHSLFS----MLIMCTILTNCVFMA---QHDPPPWTKYV----EYTF 165
Query 477 IVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
Y E L+K+ A G +L P N D + V+ E L
Sbjct 166 TAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDL------------ 213
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
L V R L+ I + + + ++ V+ + + V V
Sbjct 214 ---------GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSV 264
Query 593 FAIIGINLFRGVIVALP--------------------------------------GNSSL 614
FA+IG+ LF G + G + +
Sbjct 265 FALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTTDV 324
Query 615 APANGSAPCGSF----------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR 664
S+ G+ E ++ +FD FA A + L+ LM + W+ R
Sbjct 325 LLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLR 384
Query 665 YSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
+G I+F+L + S VNL LA++ ++ ++ + E +Q +E+
Sbjct 385 SAGKIYMIFFMLVIFLGSFYLVNLILAVV--AMAYEEQNQATIAETE-EKEKRFQEAMEM 441
Query 725 LFRDI 729
L ++
Sbjct 442 LKKEH 446
Score = 119 bits (297), Expect = 5e-26, Method: Composition-based stats.
Identities = 44/264 (17%), Positives = 91/264 (34%), Gaps = 36/264 (14%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P S + D +L +V +F+ L+ + AE ++ +L + N VF
Sbjct 702 PLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEE-MLQVGNLVFTGI 760
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM K+ AL Y N+FD ++ ++ L+ LS
Sbjct 761 FTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL--------------------GLS 800
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+L + R ++ S + + + V + +L ++ ++FA++G+
Sbjct 801 RMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 860
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF + L W DF A + ++ ++ W +
Sbjct 861 LFGK-----------NYSELRHRISDSGLLPRWHM--MDFFHAFLIIFRILCGE-WIETM 906
Query 660 -DAYRRYSGPWSKIYFVLWWLVSS 682
D + F+L ++ +
Sbjct 907 WDCMEVSGQSLCLLVFLLVMVIGN 930
Score = 103 bits (257), Expect = 3e-21, Method: Composition-based stats.
Identities = 38/183 (21%), Positives = 67/183 (37%), Gaps = 16/183 (9%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ L ++F +L + I T + D PW T+ VE ++
Sbjct 122 RRAAVKILVHSLFSMLIMCTILTNCVFMAQHDP----PPW------TKYVEYTFTAIYTF 171
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ VK G+ F ++ W V+V + T + L LR R+LR
Sbjct 172 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIV--MAYTTEFVDLGNVSALRTFRVLRALK 229
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ S +K + + S+ ++A V +L L +F + G+ LF G +
Sbjct 230 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELN 289
Query 255 FQN 257
N
Sbjct 290 GTN 292
Score = 97.5 bits (241), Expect = 2e-19, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A+++ K ++ + W + +++++SL++ +S + LR R
Sbjct 754 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLS-RMGNLSVLRSFR 812
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +
Sbjct 813 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHR 872
Query 249 RER-----LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + + +L + M S + F++ VIG+
Sbjct 873 ISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 930
Score = 44.7 bits (104), Expect = 0.004, Method: Composition-based stats.
Identities = 28/189 (15%), Positives = 63/189 (33%), Gaps = 11/189 (6%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + + +L L+T + S + Y IFF++ +GS +L+NL+ A
Sbjct 352 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILA 411
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + Q ++ + E + + E A + +
Sbjct 412 VVAMAYEEQN----QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL 467
Query 370 QLDSSHKQAMMEKVR------SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
++H++ + R G L + + L++ + R + +
Sbjct 468 APVTNHERKSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSR 527
Query 424 SAQFLFGHY 432
+ F F
Sbjct 528 GSIFTFRRR 536
>sp|O46669|SCNAA_CANLF Sodium channel protein type 10 subunit
alpha OS=Canis lupus familiaris OX=9615 GN=SCN10A PE=2 SV=1
Length=1962
Score = 548 bits (1413), Expect = 2e-173, Method: Composition-based stats.
Identities = 135/708 (19%), Positives = 260/708 (37%), Gaps = 99/708 (14%)
Query 65 RVDASSM-WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCG 123
+VD S W C R + + F + I S + D P
Sbjct 1134 KVDISKFPWTVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYHLDQKP--TVKA 1191
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLV 179
L E + + +F ++ +K +G+ + N W +++ +SL+ +
Sbjct 1192 LLEYTDRMFTFIFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLIAKILQYSDVA 1251
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F+ G+ FA
Sbjct 1252 SIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSTMGVNFFA 1311
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
G N SL+ L N D ++ + + + F +
Sbjct 1312 GKFGR----------CINKTNEYFSLVPLSIVNNISDCKYQNHTGSFFWVNVKVNFDNV- 1360
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
M L + + F+G+ M + ++ R + + +E M F G
Sbjct 1361 ---AMGYLALLQVATFKGW-MDIMYAAVDARDVNLQPKWEDNVYMYLYFVIFIIFGG--- 1413
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQ 418
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1414 FFTLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPL 1469
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + + FD + ++ N+++ ++++ D AE+ IL +N F+
Sbjct 1470 NKYQGFVFDIVTKQAFDIVIMVLICLNMIT----MMVETDEQSAEKTK-ILNKINQFFVA 1524
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ E ++K+FAL Y + NVFD + VVL + + + + P + ++
Sbjct 1525 VFTGECVMKMFALR-HYYFTNGWNVFDF-IVVVLSIGSLVFSVILTSLENYFSPTLFRVI 1582
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M + + G +L +V ++++I G+
Sbjct 1583 RLARIGRILRLIRAAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGM 1633
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
F P S+E NF FA +++ L+ + W
Sbjct 1634 ASF--------------------PHVSWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGL 1673
Query 659 LDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILENFL 698
L P+ ++F + ++S +I VN+++A+ILENF
Sbjct 1674 LSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFN 1733
Query 699 HKWDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
S PEAT +T L F D L P
Sbjct 1734 VATQESSEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGP 1781
Score = 226 bits (577), Expect = 7e-61, Method: Composition-based stats.
Identities = 61/342 (18%), Positives = 124/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + S+ D + +L + +F +
Sbjct 1148 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFE---DYHLDQKPTVKALLEYTDRMFTFIF 1204
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + Y + D L+ + L+ I+ + Y S
Sbjct 1205 VLEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLIAKILQY---------------SD 1249
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV ++G + ++ + ++ + +F+ +G+N
Sbjct 1250 VASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSTMGVNF 1309
Query 601 FRGVIVALPGNSS-------LAPANGSAPCGSFEQLE--YWAN---NFDDFAAALVTLWN 648
F G ++ L+ N + C +W N NFD+ A + L
Sbjct 1310 FAGKFGRCINKTNEYFSLVPLSIVNNISDCKYQNHTGSFFWVNVKVNFDNVAMGYLALLQ 1369
Query 649 LMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A + +YFV++ + +NLF+ +I++NF
Sbjct 1370 VATFKGWMDIMYAAVDARDVNLQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFN 1429
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1430 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1471
Score = 142 bits (359), Expect = 2e-33, Method: Composition-based stats.
Identities = 66/382 (17%), Positives = 126/382 (33%), Gaps = 93/382 (24%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A + H +F + L N V + + + VF V
Sbjct 117 NLIRRTAIKVSVHSWFSLFITVTILVNCVGM--------------TQTELPDRIEYVFTV 162
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G YL P + D + + + E + L
Sbjct 163 IYTFEALIKILARGFCLNEFAYLRDPWDWLDFSVITLAYIGEATAL-------------- 208
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ + + + V+ ++ V+ + + V VFA
Sbjct 209 -------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFA 261
Query 595 IIGINLFRGVIVALP--------------------------------------------- 609
++G+ LF+G +
Sbjct 262 LVGLQLFKGNLKNKCVKNCAALNETGNYSSYGKQEWNFCHRDEDFYYNKPGTSDPLLCGN 321
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
G+ + G + + ++ +FD FA A ++L+ LM ++W+ R SG
Sbjct 322 GSDAGHCPKGYLCLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKM 381
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDI 729
++FVL + S VNL LA++ ++ ++ + + E T+Q T+E+
Sbjct 382 YMVFFVLVIFLGSFYLVNLILAVV--TMAYEEQNQATIDEIEAK-EKTFQETLEM----- 433
Query 730 LEEPGEDELTERLSQHPHLWLC 751
++ L L C
Sbjct 434 -PRKEQEVLAALGIDTASLHSC 454
Score = 124 bits (310), Expect = 1e-27, Method: Composition-based stats.
Identities = 54/281 (19%), Positives = 103/281 (37%), Gaps = 35/281 (12%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + + D L +V VF+ ++ + + + +L I N VF V+
Sbjct 658 PTWVKLKTVLFGIVTDPFAELTTTLCIVVNTVFMAMEHHGMSSA-FEAMLQIGNIVFTVF 716
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM+ K+ A Y N+FD ++ V L+ G LS
Sbjct 717 FTAEMVFKIIAFDPYYYFQKRWNIFDCIIVTVSLI--------------ELGAARKGSLS 762
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L + R ++ S + + + V + IL ++ +VFA++G
Sbjct 763 V------LRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQ 816
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
L N N SAP + + DF + + ++ ++ W +
Sbjct 817 LLG-------ENYRDNRRNISAPNEEWPRWHMH-----DFFHSFLIVFRILCGE-WIENM 863
Query 660 DAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
A I F+ ++ +++ +NLF AL+L +F
Sbjct 864 WACMEVGQKSICLILFLTVMVLGNLVVLNLFTALLLNSFSA 904
Score = 100 bits (249), Expect = 3e-20, Method: Composition-based stats.
Identities = 51/358 (14%), Positives = 113/358 (32%), Gaps = 75/358 (21%)
Query 120 PPCGLTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVS 175
L + +E + +++ + +K G+ + ++ W V+ ++ +
Sbjct 148 TQTELPDRIEYVFTVIYTFEALIKILARGFCLNEFAYLRDPWDWLDFSVITLAYIGEAT- 206
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+L LR R+LR + +K + + S+ ++A V +L L +F + G+
Sbjct 207 -ALRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGL 265
Query 236 LLFAGGKQDDGQDRE----------------------RLTYFQNLPESLTSL-------- 265
LF G ++ ++ N P + L
Sbjct 266 QLFKGNLKNKCVKNCAALNETGNYSSYGKQEWNFCHRDEDFYYNKPGTSDPLLCGNGSDA 325
Query 266 ------LVLLTTANNPDVMIPAYSKNRA----------------------------YAIF 291
+ L T++NPD ++ Y +F
Sbjct 326 GHCPKGYLCLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVF 385
Query 292 FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF 351
F++ +GS +L+NL+ A++ + Q ++ + E L E
Sbjct 386 FVLVIFLGSFYLVNLILAVVTMAYEEQN----QATIDEIEAKEKTFQETLEMPRKEQEVL 441
Query 352 -PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+ + ++S + M+ S GS + +N+ S +
Sbjct 442 AALGIDTASLHSCNGSPLPSKNASERMRRMKPRVSEGSTDDNKSPQSDPYNQRRMSFL 499
Score = 100 bits (249), Expect = 3e-20, Method: Composition-based stats.
Identities = 39/197 (20%), Positives = 84/197 (43%), Gaps = 10/197 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ + F A++ K F ++ + W + +++ VSL++ + LR R
Sbjct 710 NIVFTVFFTAEMVFKIIAFDPYYYFQKRWNIFDCIIVTVSLIELGAA-RKGSLSVLRTFR 768
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-- 246
LLR F L ++ + +K I S+ + ++ ++LAI + +F + G L +D+
Sbjct 769 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRDNRRN 828
Query 247 ----QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIVFTVIGS 300
+ + + S + +L + M + I F+ V+G+
Sbjct 829 ISAPNEEWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGN 887
Query 301 LFLMNLLTAIIYSQFRG 317
L ++NL TA++ + F
Sbjct 888 LVVLNLFTALLLNSFSA 904
>sp|Q99250|SCN2A_HUMAN Sodium channel protein type 2 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN2A PE=1 SV=3
Length=2005
Score = 549 bits (1414), Expect = 3e-173, Method: Composition-based stats.
Identities = 131/745 (18%), Positives = 271/745 (36%), Gaps = 101/745 (14%)
Query 15 ARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY 74
+ G +V P + + C F ED ++
Sbjct 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEAC------FTEDCVRKFKCCQISIEEGKGKL 1193
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
C + + F + I S + D+ + + E + +
Sbjct 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RKTIKTMLEYADKVFTY 1251
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV T L + LR R L
Sbjct 1252 IFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1362
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN-RAYAIFFIVFTVIGSLFLMNLLTA 309
++ + + + + N + S + + F +G + L+
Sbjct 1363 ---FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVG----LGYLSL 1415
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ + F+G+ M + ++ R + + +E M F + L + V
Sbjct 1416 LQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYLY---FVIFIIFGSFFTLNLFIGV 1471
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSAQFL 428
+D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1472 IIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDF 1527
Query 429 FGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
FD ++ N+V+ ++++ D E + IL +N VFIV + E +LK+
Sbjct 1528 VTKQVFDISIMILICLNMVT----MMVETDDQSQEMTN-ILYWINLVFIVLFTGECVLKL 1582
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRML 547
+L Y + N+FD V+++L I + + L + P + ++ L + R+L
Sbjct 1583 ISLRY-YYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRIL 1637
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1638 RLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKRE 1688
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------- 659
+ + NF+ F +++ L+ + W L
Sbjct 1689 VGIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query 660 -DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE--S 1786
Query 707 LQPLAGTPEATYQMTVELLFRDILE 731
+PL+ + E D +
Sbjct 1787 AEPLSEDDFEMFYEVWEKFDPDATQ 1811
Score = 237 bits (605), Expect = 2e-64, Method: Composition-based stats.
Identities = 72/420 (17%), Positives = 144/420 (34%), Gaps = 43/420 (10%)
Query 339 EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQK 398
E + ++ + + L + + A E + S E
Sbjct 1111 ESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEAC 1170
Query 399 LFNELDRSVVKEHPPRPEYQ----SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ R E + ++ + H +F+ + L + ++
Sbjct 1171 FTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFE-- 1228
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
D + + +L + VF ++LEMLLK A G + Y + D L+ V LV
Sbjct 1229 -DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLV 1287
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ Y S + L L R LR + + M VV + +LG
Sbjct 1288 SLTANALGY---------------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1332
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF--- 626
+ ++ + ++ + +F+I+G+NLF G ++ ++ N + C +
Sbjct 1333 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIES 1392
Query 627 EQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIY 673
Q W N NFD+ ++L + W + A + +Y
Sbjct 1393 NQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
FV++ + S +NLF+ +I++NF + + Y ++ L ++P
Sbjct 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1512
Score = 126 bits (317), Expect = 2e-28, Method: Composition-based stats.
Identities = 61/372 (16%), Positives = 116/372 (31%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F N++ + +++ CVF+ + + + F
Sbjct 116 NPIRKLAIKILVHSLF----NMLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 164
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL-------------- 210
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 211 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query 595 IIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFEQLEYWA 633
+IG+ LF G + + N + ++++
Sbjct 264 LIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDK 323
Query 634 NNF-----------------------------------------DDFAAALVTLWNLMVV 652
++F D F+ A ++L+ LM
Sbjct 324 SHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 383
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 384 DFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQ 441
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 442 KEAEFQQMLEQL 453
Score = 120 bits (300), Expect = 2e-26, Method: Composition-based stats.
Identities = 38/259 (15%), Positives = 89/259 (34%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ L D +L +V +F+ ++ E+ +L + N VF + E
Sbjct 747 KVKHLVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTEQFSSVLSVGNLVFTGIFTAE 805
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M LK+ A+ Y N+FDG + + L+ L+ +
Sbjct 806 MFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------GLANVEG 845
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 905
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+ +L W + DF + + ++ ++ + D
Sbjct 906 SYKECVC-----------KISNDCELPRWHMH--DFFHSFLIVFRVLCGEWIETMWDCME 952
Query 664 RYSGPWSKIYFVLWWLVSS 682
F++ ++ +
Sbjct 953 VAGQTMCLTVFMMVMVIGN 971
Score = 94.8 bits (234), Expect = 1e-18, Method: Composition-based stats.
Identities = 44/301 (15%), Positives = 103/301 (34%), Gaps = 21/301 (7%)
Query 19 GGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYY 78
G + RS D Q + I + +
Sbjct 673 GTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKF 732
Query 79 SNVCQ--------RTLSFTIFLILFLAFIETPSSLTSTADVRY----RAAPWEPPCGLTE 126
+N+C + + L++ F++ ++ + + E +
Sbjct 733 ANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLS 792
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRI 186
++ +F A++ +K ++ + W + ++ +SL++ ++ ++ LR
Sbjct 793 VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLA-NVEGLSVLRS 851
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD- 245
RLLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 852 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 911
Query 246 ----GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIG 299
+ + S + +L + M + F++ VIG
Sbjct 912 CKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIG 970
Query 300 S 300
+
Sbjct 971 N 971
Score = 94.8 bits (234), Expect = 2e-18, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 65/167 (39%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 124 KILVHSLFNMLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 173
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V ++ T + L LR R+LR +
Sbjct 174 ILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFVDLGNVSALRTFRVLRALKTISVI 231
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 232 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 278
Score = 38.9 bits (89), Expect = 0.24, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 423 VVAMAYEEQNQATLEEA-EQKEAEFQ 447
>sp|Q14524|SCN5A_HUMAN Sodium channel protein type 5 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN5A PE=1 SV=2
Length=2016
Score = 548 bits (1413), Expect = 4e-173, Method: Composition-based stats.
Identities = 138/772 (18%), Positives = 275/772 (36%), Gaps = 108/772 (14%)
Query 2 AEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
AEPQA G T ++ P D F E ++
Sbjct 1121 AEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDV---KDPEDCFTEGCVRRCP 1177
Query 62 INHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPP 121
+ C + + F + I S + D+ +
Sbjct 1178 CCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDI--YLEERKTI 1235
Query 122 CGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LS 177
L E + + VF ++ +K +G+ + N W +++ VSLV +
Sbjct 1236 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1295
Query 178 LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
+ + LR R LRP L M+ + + ++P + +V L+ I +F++ G+ L
Sbjct 1296 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1355
Query 238 FAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANN-PDVMIPAYSKNRAYAIFFIVFT 296
FAG + + + ++ L + T NN + + + F
Sbjct 1356 FAGK------------FGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFD 1403
Query 297 VIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVG 356
+G+ +L L A F+G+ M + ++ R + +E M F +
Sbjct 1404 NVGAGYLALLQVA----TFKGW-MDIMYAAVDSRGYEEQPQWEYNLYMYIY---FVIFII 1455
Query 357 VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRP 415
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1456 FGSFFTLNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIP 1511
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
+ + + FD + N+V+ ++++ D E+ + IL +N +
Sbjct 1512 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVT----MMVETDDQSPEKIN-ILAKINLL 1566
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-WRPEM 534
F+ + E ++K+ AL Y + N+FD V+++L I + + + P +
Sbjct 1567 FVAIFTGECIVKLAALR-HYYFTNSWNIFDF----VVVILSIVGTVLSDIIQKYFFSPTL 1621
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
++ L + R+L ++ + +R + +M + + G +L +V ++++
Sbjct 1622 FRVIRLARIGRILRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYS 1672
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN 654
I G+ F V + NF FA +++ L+ +
Sbjct 1673 IFGMANFAYVKWEAGIDDM--------------------FNFQTFANSMLCLFQITTSAG 1712
Query 655 WQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALIL 694
W L P+ ++F + ++S +I VN+++A+IL
Sbjct 1713 WDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIIL 1772
Query 695 ENFLHKWDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
ENF + + PEAT + +L F D L EP
Sbjct 1773 ENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEP 1824
Score = 247 bits (630), Expect = 1e-67, Method: Composition-based stats.
Identities = 73/417 (18%), Positives = 147/417 (35%), Gaps = 51/417 (12%)
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-------FQKLFNELD 404
PQA G + D ++ ++E++ G + E+ + +D
Sbjct 1123 PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1182
Query 405 RSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
+ ++ + H +F+ + L + ++ D + +
Sbjct 1183 TTQAPGKV-----WWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFE---DIYLEERKT 1234
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
+L + +F ++LEMLLK A G + Y + D L+ V LV ++ +
Sbjct 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
P + L L R LR + + M VV + ++G + ++
Sbjct 1295 EMGP---------------IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1339
Query 585 ILVVVYYVFAIIGINLFRGVIVAL--------PGNSSLAPANGSAPCGSFEQLEYWAN-- 634
+ ++ + +F+I+G+NLF G P N ++ + YW
Sbjct 1340 VCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVK 1399
Query 635 -NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSV 683
NFD+ A + L + W + A G + IYFV++ + S
Sbjct 1400 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSF 1459
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+NLF+ +I++NF + + Y ++ L ++P L +
Sbjct 1460 FTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1516
Score = 144 bits (363), Expect = 5e-34, Method: Composition-based stats.
Identities = 89/483 (18%), Positives = 164/483 (34%), Gaps = 94/483 (19%)
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
+ N L S FR + +SL ++ +R +A EG P+ +PQ
Sbjct 1 MANFLLPRGTSSFRRFTRESL-AAIEKRMAEKQARGSTTLQESREG--LPEEEAPRPQLD 57
Query 363 LQVLQKVQ-LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPF 421
LQ +K+ L + Q ++ + S ++ + N+ SPF
Sbjct 58 LQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPF 117
Query 422 ---LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
++A + H F N++ + +++ CVF+ P ++ F
Sbjct 118 HPIRRAAVKILVHSLF----NMLIMCTILTNCVFMA---QHDPPPWTKYV----EYTFTA 166
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + ++ E L
Sbjct 167 IYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL-------------- 212
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 213 -------GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFA 265
Query 595 IIGINLFRGVIVALP--------------------------------------GNSSLAP 616
+IG+ LF G + G S +
Sbjct 266 LIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL 325
Query 617 ANGSAPCGSF----------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
S+ G+ E ++ +FD FA A + L+ LM + W+ R +
Sbjct 326 CGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSA 385
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLF 726
G I+F+L + S VNL LA++ ++ ++ + E +Q +E+L
Sbjct 386 GKIYMIFFMLVIFLGSFYLVNLILAVV--AMAYEEQNQATIAETE-EKEKRFQEAMEMLK 442
Query 727 RDI 729
++
Sbjct 443 KEH 445
Score = 120 bits (301), Expect = 2e-26, Method: Composition-based stats.
Identities = 42/264 (16%), Positives = 87/264 (33%), Gaps = 38/264 (14%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P S + D +L +V +F+ L+ + +L + N VF
Sbjct 701 PLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALE-HYNMTSEFEEMLQVGNLVFTGI 759
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM K+ AL Y N+FD ++ ++ L+ LS
Sbjct 760 FTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL--------------------GLS 799
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+L + R ++ S + + + V + +L ++ ++FA++G+
Sbjct 800 RMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 859
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF L + S DF A + ++ ++ W +
Sbjct 860 LFGKNYSELRDSDSGLLPRWHMM---------------DFFHAFLIIFRILCGE-WIETM 903
Query 660 -DAYRRYSGPWSKIYFVLWWLVSS 682
D + F+L ++ +
Sbjct 904 WDCMEVSGQSLCLLVFLLVMVIGN 927
Score = 102 bits (254), Expect = 6e-21, Method: Composition-based stats.
Identities = 37/184 (20%), Positives = 67/184 (36%), Gaps = 16/184 (9%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ L ++F +L + I T + D PW T+ VE ++
Sbjct 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP----PPW------TKYVEYTFTAIYT 169
Query 138 ADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ VK G+ F ++ W V++ + T + L LR R+LR
Sbjct 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVII--MAYTTEFVDLGNVSALRTFRVLRAL 227
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLT 253
+ S +K + + S+ ++A V +L L +F + G+ LF G +
Sbjct 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTAL 287
Query 254 YFQN 257
N
Sbjct 288 NGTN 291
Score = 97.9 bits (242), Expect = 2e-19, Method: Composition-based stats.
Identities = 34/177 (19%), Positives = 76/177 (43%), Gaps = 7/177 (4%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A+++ K ++ + W + +++++SL++ +S + LR R
Sbjct 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLS-RMSNLSVLRSFR 811
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +
Sbjct 812 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDS 871
Query 249 RER---LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + + +L + M S + F++ VIG+
Sbjct 872 DSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 927
Score = 42.0 bits (97), Expect = 0.023, Method: Composition-based stats.
Identities = 28/189 (15%), Positives = 62/189 (33%), Gaps = 11/189 (6%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + + +L L+T + S + Y IFF++ +GS +L+NL+ A
Sbjct 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILA 410
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + Q ++ + E + + E A + +
Sbjct 411 VVAMAYEEQN----QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL 466
Query 370 QLDSSHKQAMMEKVRSY------GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
+SH++ + R G L + + ++ + R + +
Sbjct 467 APVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSR 526
Query 424 SAQFLFGHY 432
+ F F
Sbjct 527 GSIFTFRRR 535
>sp|B1AWN6|SCN2A_MOUSE Sodium channel protein type 2 subunit alpha
OS=Mus musculus OX=10090 GN=Scn2a PE=1 SV=1
Length=2006
Score = 548 bits (1411), Expect = 6e-173, Method: Composition-based stats.
Identities = 127/708 (18%), Positives = 263/708 (37%), Gaps = 95/708 (13%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
F ED ++ C + + F + I S + D+
Sbjct 1172 FTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDI 1231
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
+ + E + + +F ++ +K +G+ + N W +++ VSLV
Sbjct 1232 YIEQ--RKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVS 1289
Query 172 WTV----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
T L + LR R LRP L M+ + + ++P + +V L+ I
Sbjct 1290 LTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFW 1349
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN-R 286
+F++ G+ LFAG ++ + + + + N + S
Sbjct 1350 LIFSIMGVNLFAGK------------FYHCINYTTGEMFDVSVVNNYSECQALIESNQTA 1397
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
+ + F +G + L+ + + F+G+ M + ++ R + + +E M
Sbjct 1398 RWKNVKVNFDNVG----LGYLSLLQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYL 1452
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
F + L + V +D+ ++Q K + G + EE +K +N + +
Sbjct 1453 Y---FVIFIIFGSFFTLNLFIGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKL 1505
Query 407 VVKEH-PPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD 465
K+ P P + F FD ++ N+V+ ++++ D E
Sbjct 1506 GSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVT----MMVETDDQSQEMT 1561
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ IL +N VFIV + E +LK+ +L Y + N+FD V+++L I + + L
Sbjct 1562 N-ILYWINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAEL 1615
Query 526 PHPGW-RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ P + ++ L + R+L ++ + +R + +M + + G
Sbjct 1616 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGL 1666
Query 585 ILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
+L +V +++AI G++ F V + + NF+ F +++
Sbjct 1667 LLFLVMFIYAIFGMSNFAYVKREVGIDDM--------------------FNFETFGNSMI 1706
Query 645 TLWNLMVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSV 683
L+ + W L D P S + +FV + ++S +
Sbjct 1707 CLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFL 1766
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ VN+++A+ILENF + +PL+ + E D +
Sbjct 1767 VVVNMYIAVILENFSVATEE--SAEPLSEDDFEMFYEVWEKFDPDATQ 1812
Score = 238 bits (608), Expect = 9e-65, Method: Composition-based stats.
Identities = 72/420 (17%), Positives = 144/420 (34%), Gaps = 43/420 (10%)
Query 339 EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQK 398
E + ++ + + L + + A E + S E
Sbjct 1112 ESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEAC 1171
Query 399 LFNELDRSVVKEHPPRPEYQ----SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ R E + ++ + H +F+ + L + ++
Sbjct 1172 FTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFE-- 1229
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
D + + +L + VF ++LEMLLK A G + Y + D L+ V LV
Sbjct 1230 -DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLV 1288
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ Y S + L L R LR + + M VV + +LG
Sbjct 1289 SLTANALGY---------------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1333
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF--- 626
+ ++ + ++ + +F+I+G+NLF G ++ ++ N + C +
Sbjct 1334 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIES 1393
Query 627 EQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIY 673
Q W N NFD+ ++L + W + A + +Y
Sbjct 1394 NQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1453
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
FV++ + S +NLF+ +I++NF + + Y ++ L ++P
Sbjct 1454 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1513
Score = 127 bits (319), Expect = 1e-28, Method: Composition-based stats.
Identities = 61/372 (16%), Positives = 116/372 (31%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F N++ + +++ CVF+ + + + F
Sbjct 116 NPIRKLAIKILVHSLF----NVLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 164
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 165 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNL-------------- 210
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 211 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query 595 IIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFEQLEYWA 633
+IG+ LF G + + N + ++++
Sbjct 264 LIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTMNMFNWDEYIEDK 323
Query 634 NNF-----------------------------------------DDFAAALVTLWNLMVV 652
++F D F+ A ++L+ LM
Sbjct 324 SHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 383
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 384 DFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQ 441
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 442 KEAEFQQMLEQL 453
Score = 120 bits (301), Expect = 1e-26, Method: Composition-based stats.
Identities = 37/259 (14%), Positives = 89/259 (34%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + D +L +V +F+ ++ E+ +L + N VF + E
Sbjct 748 KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTEQFSSVLSVGNLVFTGIFTAE 806
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M LK+ A+ Y N+FDG + + L+ L+ +
Sbjct 807 MFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------GLANVEG 846
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 847 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 906
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+ +L W + DF + + ++ ++ + D
Sbjct 907 SYKECVC-----------KISNDCELPRWHMH--DFFHSFLIVFRVLCGEWIETMWDCME 953
Query 664 RYSGPWSKIYFVLWWLVSS 682
F++ ++ +
Sbjct 954 VAGQTMCLTVFMMVMVIGN 972
Score = 95.2 bits (235), Expect = 1e-18, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 66/167 (40%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 124 KILVHSLFNVLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 173
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V ++ T ++L LR R+LR +
Sbjct 174 ILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFVNLGNVSALRTFRVLRALKTISVI 231
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 232 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 278
Score = 94.4 bits (233), Expect = 2e-18, Method: Composition-based stats.
Identities = 47/316 (15%), Positives = 109/316 (34%), Gaps = 22/316 (7%)
Query 4 PQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSIN 63
P A + P +G G + RS D Q + + +
Sbjct 660 PSALTSP-VGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSMASILTNTMEE 718
Query 64 HRVDASSMWLYRRYYSNVCQ--------RTLSFTIFLILFLAFIETPSSLTSTADVRY-- 113
++N+C + + L++ F++ ++ + +
Sbjct 719 LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 778
Query 114 --RAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
E + ++ +F A++ +K ++ + W + ++ +SL++
Sbjct 779 MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 838
Query 172 WTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
++ ++ LR RLLR F L ++ + +K I S+ + ++ L+LAI + +F
Sbjct 839 LGLA-NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFA 897
Query 232 MFGMLLFAGGKQDD-----GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSK 284
+ GM LF ++ + + S + +L + M +
Sbjct 898 VVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAG 956
Query 285 NRAYAIFFIVFTVIGS 300
F++ VIG+
Sbjct 957 QTMCLTVFMMVMVIGN 972
Score = 38.9 bits (89), Expect = 0.24, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 423 VVAMAYEEQNQATLEEA-EQKEAEFQ 447
>sp|Q9JJV9|SCN5A_MOUSE Sodium channel protein type 5 subunit alpha
OS=Mus musculus OX=10090 GN=Scn5a PE=1 SV=2
Length=2019
Score = 548 bits (1411), Expect = 7e-173, Method: Composition-based stats.
Identities = 138/772 (18%), Positives = 275/772 (36%), Gaps = 108/772 (14%)
Query 2 AEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
AEP+A G T ++ P D F E ++
Sbjct 1123 AEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDV---KDPEDCFTEGCVRRCP 1179
Query 62 INHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPP 121
+ C R + + F + I S + D+ +
Sbjct 1180 CCMVDTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDI--YLEERKTI 1237
Query 122 CGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LS 177
L E + + VF ++ +K +G+ + N W +++ VSLV +
Sbjct 1238 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1297
Query 178 LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
+ + LR R LRP L M+ + + ++P + +V L+ I +F++ G+ L
Sbjct 1298 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1357
Query 238 FAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANN-PDVMIPAYSKNRAYAIFFIVFT 296
FAG + + + ++ L + T NN + + + + F
Sbjct 1358 FAGK------------FGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFD 1405
Query 297 VIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVG 356
+G+ +L L A F+G+ M + ++ R + +E M F
Sbjct 1406 NVGAGYLALLQVA----TFKGW-MDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIF-- 1458
Query 357 VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRP 415
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1459 -GSFFTLNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIP 1513
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
+ + + FD + N+V+ ++++ D E+ + IL +N +
Sbjct 1514 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVT----MMVETDDQSPEKVN-ILAKINLL 1568
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-WRPEM 534
F+ + E ++K+ AL Y + N+FD V+++L I + + + P +
Sbjct 1569 FVAIFTGECIVKMAALR-HYYFTNSWNIFDF----VVVILSIVGTVLSDIIQKYFFSPTL 1623
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
++ L + R+L ++ + +R + +M + + G +L +V ++++
Sbjct 1624 FRVIRLARIGRILRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYS 1674
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN 654
I G+ F V + NF FA +++ L+ +
Sbjct 1675 IFGMANFAYVKWEAGIDDM--------------------FNFQTFANSMLCLFQITTSAG 1714
Query 655 WQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALIL 694
W L P+ ++F + ++S +I VN+++A+IL
Sbjct 1715 WDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIIL 1774
Query 695 ENFLHKWDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
ENF + + PEAT + L F D L EP
Sbjct 1775 ENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEP 1826
Score = 245 bits (626), Expect = 3e-67, Method: Composition-based stats.
Identities = 64/343 (19%), Positives = 126/343 (37%), Gaps = 39/343 (11%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
++ + H +F+ + L + ++ D + + +L + +F
Sbjct 1194 WRLRKTCYRIVEHSWFETFIIFMILLSSGALAFE---DIYLEERKTIKVLLEYADKMFTY 1250
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
++LEMLLK A G + Y + D L+ V LV ++ + P
Sbjct 1251 VFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGP---------- 1300
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+
Sbjct 1301 -----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1355
Query 599 NLFRGVIVAL--------PGNSSLAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTLW 647
NLF G P N ++ + YW NFD+ A + L
Sbjct 1356 NLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALL 1415
Query 648 NLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ W + A G + IYFV++ + S +NLF+ +I++NF
Sbjct 1416 QVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF 1475
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1476 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1518
Score = 141 bits (356), Expect = 4e-33, Method: Composition-based stats.
Identities = 87/485 (18%), Positives = 159/485 (33%), Gaps = 98/485 (20%)
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
+ N L S FR + +SL ++ +R +A S EG P+ +PQ
Sbjct 1 MANFLLPRGTSSFRRFTRESL-AAIEKRMAEKQARGSATSQESREG--LPEEEAPRPQLD 57
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------E 416
LQ +K+ + + + QK F L++
Sbjct 58 LQASKKLPDLYGNPPRELIGEPLEDLDPFYST--QKTFIVLNKGKTIFRFSATNALYVLS 115
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
P ++A + H F ++ + +++ CVF+ P ++ F
Sbjct 116 PFHPVRRAAVKILVHSLFS----MLIMCTILTNCVFMA---QHDPPPWTKYV----EYTF 164
Query 477 IVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
Y E L+K+ A G +L P N D + V+ E L
Sbjct 165 TAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLG----------- 213
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
L V R L+ I + + + ++ V+ + + V V
Sbjct 214 ----------NVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSV 263
Query 593 FAIIGINLFRGVIVALP--------------------------------------GNSSL 614
FA+IG+ LF G + G + +
Sbjct 264 FALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDV 323
Query 615 APANGSAPCGSF----------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR 664
S+ G+ E ++ +FD FA A + L+ LM + W+ R
Sbjct 324 LLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLR 383
Query 665 YSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
+G I+F+L + S VNL LA++ ++ ++ + E +Q +E+
Sbjct 384 SAGKIYMIFFMLVIFLGSFYLVNLILAVV--AMAYEEQNQATIAETE-EKEKRFQEAMEM 440
Query 725 LFRDI 729
L ++
Sbjct 441 LKKEH 445
Score = 119 bits (297), Expect = 5e-26, Method: Composition-based stats.
Identities = 44/264 (17%), Positives = 91/264 (34%), Gaps = 36/264 (14%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P S + D +L +V +F+ L+ + AE ++ +L + N VF
Sbjct 701 PLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMTAEFEE-MLQVGNLVFTGI 759
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM K+ AL Y N+FD ++ ++ L+ LS
Sbjct 760 FTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMEL--------------------GLS 799
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+L + R ++ S + + + V + +L ++ ++FA++G+
Sbjct 800 RMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 859
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF + L W DF A + ++ ++ W +
Sbjct 860 LFGK-----------NYSELRHRISDSGLLPRWHM--MDFFHAFLIIFRILCGE-WIETM 905
Query 660 -DAYRRYSGPWSKIYFVLWWLVSS 682
D + F+L ++ +
Sbjct 906 WDCMEVSGQSLCLLVFLLVMVIGN 929
Score = 103 bits (257), Expect = 3e-21, Method: Composition-based stats.
Identities = 38/183 (21%), Positives = 67/183 (37%), Gaps = 16/183 (9%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ L ++F +L + I T + D PW T+ VE ++
Sbjct 121 RRAAVKILVHSLFSMLIMCTILTNCVFMAQHDP----PPW------TKYVEYTFTAIYTF 170
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ VK G+ F ++ W V+V + T + L LR R+LR
Sbjct 171 ESLVKILARGFCLHAFTFLRDPWNWLDFSVIV--MAYTTEFVDLGNVSALRTFRVLRALK 228
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ S +K + + S+ ++A V +L L +F + G+ LF G +
Sbjct 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELN 288
Query 255 FQN 257
N
Sbjct 289 GTN 291
Score = 97.5 bits (241), Expect = 2e-19, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A+++ K ++ + W + +++++SL++ +S + LR R
Sbjct 753 NLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLS-RMGNLSVLRSFR 811
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +
Sbjct 812 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHR 871
Query 249 RER-----LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + + +L + M S + F++ VIG+
Sbjct 872 ISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 929
Score = 42.0 bits (97), Expect = 0.025, Method: Composition-based stats.
Identities = 27/189 (14%), Positives = 62/189 (33%), Gaps = 11/189 (6%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + + +L L+T + S + Y IFF++ +GS +L+NL+ A
Sbjct 351 GYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILA 410
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + Q ++ + E + + E A + +
Sbjct 411 VVAMAYEEQN----QATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPL 466
Query 370 QLDSSHKQAMMEKV------RSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
++H++ + G L + + L++ + R + +
Sbjct 467 APVTNHERRSKRRKRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSR 526
Query 424 SAQFLFGHY 432
+ F F
Sbjct 527 GSIFTFRRR 535
>sp|P04775|SCN2A_RAT Sodium channel protein type 2 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn2a PE=1 SV=1
Length=2005
Score = 548 bits (1411), Expect = 7e-173, Method: Composition-based stats.
Identities = 127/708 (18%), Positives = 263/708 (37%), Gaps = 95/708 (13%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
F ED ++ C + + F + I S + D+
Sbjct 1171 FTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDI 1230
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
+ + E + + +F ++ +K +G+ + N W +++ VSLV
Sbjct 1231 YIEQ--RKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVS 1288
Query 172 WTV----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
T L + LR R LRP L M+ + + ++P + +V L+ I
Sbjct 1289 LTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFW 1348
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN-R 286
+F++ G+ LFAG ++ + + + + N + S
Sbjct 1349 LIFSIMGVNLFAGK------------FYHCINYTTGEMFDVSVVNNYSECQALIESNQTA 1396
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
+ + F +G + L+ + + F+G+ M + ++ R + + +E M
Sbjct 1397 RWKNVKVNFDNVG----LGYLSLLQVATFKGW-MDIMYAAVDSRNVELQPKYEDNLYMYL 1451
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
F + L + V +D+ ++Q K + G + EE +K +N + +
Sbjct 1452 Y---FVIFIIFGSFFTLNLFIGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKL 1504
Query 407 VVKEH-PPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD 465
K+ P P + F FD ++ N+V+ ++++ D E
Sbjct 1505 GSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVT----MMVETDDQSQEMT 1560
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ IL +N VFIV + E +LK+ +L Y + N+FD V+++L I + + L
Sbjct 1561 N-ILYWINLVFIVLFTGECVLKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAEL 1614
Query 526 PHPGW-RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ P + ++ L + R+L ++ + +R + +M + + G
Sbjct 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGL 1665
Query 585 ILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
+L +V +++AI G++ F V + + NF+ F +++
Sbjct 1666 LLFLVMFIYAIFGMSNFAYVKREVGIDDM--------------------FNFETFGNSMI 1705
Query 645 TLWNLMVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSV 683
L+ + W L D P S + +FV + ++S +
Sbjct 1706 CLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFL 1765
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ VN+++A+ILENF + +PL+ + E D +
Sbjct 1766 VVVNMYIAVILENFSVATEE--SAEPLSEDDFEMFYEVWEKFDPDATQ 1811
Score = 238 bits (607), Expect = 9e-65, Method: Composition-based stats.
Identities = 72/420 (17%), Positives = 144/420 (34%), Gaps = 43/420 (10%)
Query 339 EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQK 398
E + ++ + + L + + A E + S E
Sbjct 1111 ESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEAC 1170
Query 399 LFNELDRSVVKEHPPRPEYQ----SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ R E + ++ + H +F+ + L + ++
Sbjct 1171 FTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFE-- 1228
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
D + + +L + VF ++LEMLLK A G + Y + D L+ V LV
Sbjct 1229 -DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLV 1287
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ Y S + L L R LR + + M VV + +LG
Sbjct 1288 SLTANALGY---------------SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1332
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSF--- 626
+ ++ + ++ + +F+I+G+NLF G ++ ++ N + C +
Sbjct 1333 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIES 1392
Query 627 EQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIY 673
Q W N NFD+ ++L + W + A + +Y
Sbjct 1393 NQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
Query 674 FVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
FV++ + S +NLF+ +I++NF + + Y ++ L ++P
Sbjct 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1512
Score = 127 bits (318), Expect = 1e-28, Method: Composition-based stats.
Identities = 61/372 (16%), Positives = 116/372 (31%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F N++ + +++ CVF+ + + + F
Sbjct 116 NPIRKLAIKILVHSLF----NVLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 164
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 165 IYTFESLIKILARGFCLEDFTFLRNPWNWLDFTVITFAYVTEFVNL-------------- 210
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 211 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
Query 595 IIGINLFRG---------------------VIVALPGNSSLAPANGSAPCGSFEQLEYWA 633
+IG+ LF G + + N + ++++
Sbjct 264 LIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDK 323
Query 634 NNF-----------------------------------------DDFAAALVTLWNLMVV 652
++F D F+ A ++L+ LM
Sbjct 324 SHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 383
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 384 DFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQ 441
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 442 KEAEFQQMLEQL 453
Score = 119 bits (299), Expect = 3e-26, Method: Composition-based stats.
Identities = 36/259 (14%), Positives = 88/259 (34%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + D +L +V +F+ ++ E+ +L + N VF + E
Sbjct 747 KVKHVVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTEQFSSVLSVGNLVFTGIFTAE 805
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M LK+ A+ Y N+FDG + + L+ L+ +
Sbjct 806 MFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------GLANVEG 845
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 846 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 905
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+ +L W + F + + ++ ++ + D
Sbjct 906 SYKECVC-----------KISNDCELPRWHMH--HFFHSFLIVFRVLCGEWIETMWDCME 952
Query 664 RYSGPWSKIYFVLWWLVSS 682
F++ ++ +
Sbjct 953 VAGQTMCLTVFMMVMVIGN 971
Score = 97.1 bits (240), Expect = 3e-19, Method: Composition-based stats.
Identities = 32/167 (19%), Positives = 66/167 (40%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 124 KILVHSLFNVLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 173
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F +N W V ++ T ++L LR R+LR +
Sbjct 174 ILARGFCLEDFTFLRNPWNWLDFTV--ITFAYVTEFVNLGNVSALRTFRVLRALKTISVI 231
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 232 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 278
Score = 92.9 bits (229), Expect = 7e-18, Method: Composition-based stats.
Identities = 33/179 (18%), Positives = 75/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SL++ ++ ++ LR R
Sbjct 795 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLA-NVEGLSVLRSFR 853
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 854 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 913
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + S + +L + M + F++ VIG+
Sbjct 914 ISNDCELPRWHMHHFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Score = 38.9 bits (89), Expect = 0.24, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 363 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 423 VVAMAYEEQNQATLEEA-EQKEAEFQ 447
>sp|Q9WTU3|SCN8A_MOUSE Sodium channel protein type 8 subunit alpha
OS=Mus musculus OX=10090 GN=Scn8a PE=1 SV=1
Length=1978
Score = 547 bits (1408), Expect = 1e-172, Method: Composition-based stats.
Identities = 136/754 (18%), Positives = 276/754 (37%), Gaps = 95/754 (13%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
+ES+P + G T +V + + +D F E +Q
Sbjct 1113 SESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQV 1172
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+ C + F + I S + D+ + +
Sbjct 1173 NIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQ--RKTIRTIL 1230
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCH 181
E + + +F ++ +K +G+ F N W +++ VSLV L
Sbjct 1231 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1290
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1291 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1350
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDV--MIPAYSKNRAYAIFFIVFTVIG 299
+ + + N D ++ + + I F +G
Sbjct 1351 YHYCFNETSEI------------RFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVG 1398
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
+ +L L A F+G+ M + ++ R+ + +E M F +
Sbjct 1399 AGYLALLQVA----TFKGW-MDIMYAAVDSRKPDEQPDYEGNIYMYIY---FVIFIIFGS 1450
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQ 418
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1451 FFTLNLFIGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPL 1506
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ FD + ++ N+V+ ++++ D + ++ IL +N VF++
Sbjct 1507 NKIQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWINLVFVI 1561
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGL 537
++ E +LK+FAL Y + N+FD V+++L I + + + + P + +
Sbjct 1562 FFTCECVLKMFALR-HYYFTIGWNIFDF----VVVILSIVGMFLADIIEKYFVSPTLFRV 1616
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ L + R+L ++ + +R + +M + + G +L +V ++F+I G
Sbjct 1617 IRLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIFSIFG 1667
Query 598 INLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
++ F V + NF+ F +++ L+ + W
Sbjct 1668 MSNFAYVKHEAGIDDM--------------------FNFETFGNSMICLFQITTSAGWDG 1707
Query 658 FL--------DAYRRYSGPWS------------KIYFVLWWLVSSVIWVNLFLALILENF 697
L D P S +FV + ++S +I VN+++A+ILENF
Sbjct 1708 LLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1767
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + PL+ T+ E D +
Sbjct 1768 SVATEESAD--PLSEDDFETFYEIWEKFDPDATQ 1799
Score = 233 bits (595), Expect = 3e-63, Method: Composition-based stats.
Identities = 66/342 (19%), Positives = 123/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + + IL + VF +
Sbjct 1185 LRKTCFLIVEHNWFETFIIFMILLSSGALAFE---DIYIEQRKTIRTILEYADKVFTYIF 1241
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + + D L+ V LV I+ Y S
Sbjct 1242 ILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---------------SE 1286
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+NL
Sbjct 1287 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1346
Query 601 FRGVIVALPGNSSL---------APANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWN 648
F G +S + W N NFD+ A + L
Sbjct 1347 FAGKYHYCFNETSEIRFEIDEVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQ 1406
Query 649 LMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A P + IYFV++ + S +NLF+ +I++NF
Sbjct 1407 VATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1466
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1467 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1508
Score = 131 bits (328), Expect = 9e-30, Method: Composition-based stats.
Identities = 63/334 (19%), Positives = 106/334 (32%), Gaps = 81/334 (24%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A + H F +I + +++ CVF+ P E + F
Sbjct 119 NLIRRIAIKILIHSVFS----MIIMCTILTNCVFMTFS---NPPEWSKNV----EYTFTG 167
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + ++ V E L
Sbjct 168 IYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDL-------------- 213
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 214 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 266
Query 595 IIGINLFRG-----------------------------------VIVALPG--------- 610
+IG+ LF G +PG
Sbjct 267 LIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGN 326
Query 611 -NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+ + G + Y +FD F+ A + L+ LM + W+ R +G
Sbjct 327 SSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT 386
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
I+FVL V S VNL LA++ + +
Sbjct 387 YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
Score = 125 bits (315), Expect = 3e-28, Method: Composition-based stats.
Identities = 40/263 (15%), Positives = 93/263 (35%), Gaps = 34/263 (13%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P+ + + D +L +V +F+ ++ + + + +L + N VF
Sbjct 735 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGI 793
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM LK+ A+ Y N+FDG + + L+ L+
Sbjct 794 FTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------GLA 833
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 834 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 893
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF S +L W N DF + + ++ ++ +
Sbjct 894 LFGKSYKECVCKISQEC-----------KLPRWHMN--DFFHSFLIVFRVLCGEWIETMW 940
Query 660 DAYRRYSGPWSKIYFVLWWLVSS 682
D I F++ ++ +
Sbjct 941 DCMEVAGQAMCLIVFMMVMVIGN 963
Score = 99.4 bits (246), Expect = 6e-20, Method: Composition-based stats.
Identities = 52/317 (16%), Positives = 108/317 (34%), Gaps = 80/317 (25%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ + L ++F ++ + I T + + W +++VE ++
Sbjct 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFS----NPPEW------SKNVEYTFTGIYT 170
Query 138 ADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ VK G+ F ++ W V++++ V V L LR R+LR
Sbjct 171 FESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFV--DLGNVSALRTFRVLRAL 228
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINF 288
Query 247 ---------------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD- 276
+ T F +P L L + NP+
Sbjct 289 NESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNY 348
Query 277 -----------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTA 309
+M Y +N + Y IFF++ +GS +L+NL+ A
Sbjct 349 GYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILA 408
Query 310 IIYSQFRGYLMKSLQTS 326
++ + +L+ +
Sbjct 409 VVAMAYEEQNQATLEEA 425
Score = 94.0 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SL++ ++ + LR R
Sbjct 787 NLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLA-DVEGLSVLRSFR 845
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 846 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 905
Query 249 RER-----LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + I F++ VIG+
Sbjct 906 ISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 963
>sp|Q6QIY3|SCNAA_MOUSE Sodium channel protein type 10 subunit
alpha OS=Mus musculus OX=10090 GN=Scn10a PE=1 SV=2
Length=1958
Score = 546 bits (1407), Expect = 2e-172, Method: Composition-based stats.
Identities = 125/693 (18%), Positives = 262/693 (38%), Gaps = 88/693 (13%)
Query 65 RVDASSM-WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCG 123
+V+ S W C R + + F + I S + D P
Sbjct 1128 KVNTSKFPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVK--S 1185
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLV 179
+ E + + +F ++ +K +G+ + N W +++ +SL +
Sbjct 1186 VLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVA 1245
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1246 SIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1305
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
G R F + + + N D Y++N F++ V
Sbjct 1306 GKFSRCVD--TRSNPFSVVNSTFVT--------NKSDC----YNQNNTGHFFWVNVKVNF 1351
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
M L + + F+G+ M + ++ R + ++ +E M F G
Sbjct 1352 DNVAMGYLALLQVATFKGW-MDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGG--- 1407
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQ 418
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1408 FFTLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPL 1463
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + + FD + + N+++ ++++ D E+ +LG +N F+
Sbjct 1464 NKYQGFVFDIVTRQAFDIIIMALICLNMIT----MMVETDNQSEEKTK-VLGRINQFFVA 1518
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ E ++K+FAL + Y + NVFD + V+L + + A+ + P ++ ++
Sbjct 1519 VFTGECVMKMFALR-QYYFTNGWNVFDF-IVVILSISSLLFSAILSSLESYFSPTLLRVI 1576
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M + + G +L +V ++++I G+
Sbjct 1577 RLARIGRILRLIRAAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGM 1627
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
F VI + NF F +++ L+ + W
Sbjct 1628 ASFANVIDEAGIDDM--------------------FNFKTFGNSMLCLFQITTSAGWDGL 1667
Query 659 LDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILENFL 698
L P+ ++F + ++S +I VN+++A+ILENF
Sbjct 1668 LSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFN 1727
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + +PL+ + T E + +
Sbjct 1728 VATEEST--EPLSEDDFDMFYETWEKFDPEATQ 1758
Score = 230 bits (586), Expect = 5e-62, Method: Composition-based stats.
Identities = 62/342 (18%), Positives = 122/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + R +L + VF +
Sbjct 1142 VRKTCYRIVEHSWFESFIIFMILLSSGALAFE---DNYLEEKPRVKSVLEYTDRVFTFIF 1198
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+ EMLLK A G + Y + D L+ + L I+ + Y S
Sbjct 1199 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEY---------------SD 1243
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV ++G + ++ + ++ + +F+I+G+NL
Sbjct 1244 VASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1303
Query 601 FRGVIVALPG---------NSSLAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWN 648
F G NS+ + +W N NFD+ A + L
Sbjct 1304 FAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGHFFWVNVKVNFDNVAMGYLALLQ 1363
Query 649 LMVVNNWQVFLDAYRRY----------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A + +YFV++ + +NLF+ +I++NF
Sbjct 1364 VATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFN 1423
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1424 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1465
Score = 146 bits (367), Expect = 2e-34, Method: Composition-based stats.
Identities = 64/349 (18%), Positives = 120/349 (34%), Gaps = 77/349 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A + H +F + L N V + + L F V
Sbjct 117 NLIRRTAIKVSVHSWFSIFITVTILVNCVCM--------------TRTDLPEKLEYAFTV 162
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G YL P N D + + V L
Sbjct 163 VYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL-------------- 208
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ + + + V+ ++ V+ + + V VFA
Sbjct 209 -------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFA 261
Query 595 IIGINLFRG--------------------------VIVALPGNSSLAPANGSA------- 621
++G+ LF+G + + L NGS
Sbjct 262 LVGLQLFKGNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTTDPLLCGNGSDAGHCPND 321
Query 622 --PCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWL 679
+ + ++ +FD FA A ++L+ LM ++W+ R SG ++FVL
Sbjct 322 YVCRKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIF 381
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
+ S VNL LA++ ++ ++ + + E ++ +E+L ++
Sbjct 382 LGSFYLVNLILAVV--TMAYEEQSQATIAEIEAK-EKKFKEALEVLQKE 427
Score = 121 bits (303), Expect = 9e-27, Method: Composition-based stats.
Identities = 49/281 (17%), Positives = 100/281 (36%), Gaps = 35/281 (12%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + + + D L +V VF+ ++ + D +L N VF V+
Sbjct 648 PKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAME-HYPMTDAFDAMLQAGNIVFTVF 706
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ +EM K+ A Y N+FD ++ V L+ G LS
Sbjct 707 FTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLL--------------ELSTSKKGSLS 752
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L + R ++ S + ++ + V + IL ++ ++FA++G
Sbjct 753 V------LRTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQ 806
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
L S E + DF + + ++ ++ W +
Sbjct 807 LLS------------ENYGCRRDGISVWNGERLRWHMCDFFHSFLVVFRILCGE-WIENM 853
Query 660 DAYRRYSGPW-SKIYFVLWWLVSSVIWVNLFLALILENFLH 699
S + F+ ++ +++ +NLF+AL+L +F
Sbjct 854 WVCMEVSQDYICLTLFLTVMVLGNLVVLNLFIALLLNSFSA 894
Score = 110 bits (274), Expect = 2e-23, Method: Composition-based stats.
Identities = 50/343 (15%), Positives = 111/343 (32%), Gaps = 63/343 (18%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLV 179
L E +E +V+ + +K G+ + ++ W V ++L ++ L
Sbjct 152 LPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSV--ITLAYVGAAIDLR 209
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR R+LR + +K + + S+ ++A V +L L +F + G+ LF
Sbjct 210 GISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFK 269
Query 240 GGKQDDG----------------------------------------------------- 246
G ++
Sbjct 270 GNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTTDPLLCGNGSDAGHCPNDYVCRKTSD 329
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS-KNRAYAIFFIVFTVIGSLFLMN 305
T F + + SL L+T + + + Y +FF++ +GS +L+N
Sbjct 330 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVN 389
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L+ A++ + ++ + + + A EVL + +
Sbjct 390 LILAVVTMAYEEQSQATI-AEIEAKEKKFKEALEVL--QKEQEVLAALGIDTTSLYSHNG 446
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+++ ++ ++ S GS + +N+ S +
Sbjct 447 SPLAPKNANERRPRVKSRMSEGSTDDNRSLQSDPYNQRRMSFL 489
Score = 97.5 bits (241), Expect = 2e-19, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 84/203 (41%), Gaps = 10/203 (5%)
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
+ ++ ++ + F +++ K F ++ + W + V++ VSL++ + S
Sbjct 694 AMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTS-KKGSLS 752
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR RLLR F L ++ + +K I S+ + ++ +LAI + +F + G L +
Sbjct 753 VLRTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENY 812
Query 243 QDDGQDRE------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIV 294
+ + S + +L + M ++ Y F+
Sbjct 813 GCRRDGISVWNGERLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEVSQDYICLTLFLT 871
Query 295 FTVIGSLFLMNLLTAIIYSQFRG 317
V+G+L ++NL A++ + F
Sbjct 872 VMVLGNLVVLNLFIALLLNSFSA 894
>sp|Q9UQD0|SCN8A_HUMAN Sodium channel protein type 8 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN8A PE=1 SV=1
Length=1980
Score = 546 bits (1407), Expect = 2e-172, Method: Composition-based stats.
Identities = 137/752 (18%), Positives = 276/752 (37%), Gaps = 91/752 (12%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
+ES+P + G T +V + + +D F E +Q
Sbjct 1115 SESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQV 1174
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+ C + F + I S + D+ + +
Sbjct 1175 NIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQ--RKTIRTIL 1232
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCH 181
E + + +F ++ +K +G+ F N W +++ VSLV L
Sbjct 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSL 301
+ + + + T L+ N + I F +G+
Sbjct 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNN----------TEIRWKNVKINFDNVGAG 1402
Query 302 FLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQN 361
+L L A F+G+ M + ++ R+ + +E M F +
Sbjct 1403 YLALLQVA----TFKGW-MDIMYAAVDSRKPDEQPKYEDNIYMYIY---FVIFIIFGSFF 1454
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSP 420
L + V +D+ ++Q K + G + EE +K +N + + K+ P P +
Sbjct 1455 TLNLFIGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
FD + ++ N+V+ ++++ D + ++ IL +N VF++++
Sbjct 1511 IQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWINLVFVIFF 1565
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLS 539
E +LK+FAL Y + N+FD V+++L I + + + + P + ++
Sbjct 1566 TCECVLKMFALR-HYYFTIGWNIFDF----VVVILSIVGMFLADIIEKYFVSPTLFRVIR 1620
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
L + R+L ++ + +R + +M + + G +L +V ++F+I G++
Sbjct 1621 LARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIFSIFGMS 1671
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
F V + NF+ F +++ L+ + W L
Sbjct 1672 NFAYVKHEAGIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLL 1711
Query 660 --------DAYRRYSGPWS------------KIYFVLWWLVSSVIWVNLFLALILENFLH 699
D P S +FV + ++S +I VN+++A+ILENF
Sbjct 1712 LPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + PL+ T+ E D +
Sbjct 1772 ATEESAD--PLSEDDFETFYEIWEKFDPDATQ 1801
Score = 234 bits (596), Expect = 3e-63, Method: Composition-based stats.
Identities = 68/342 (20%), Positives = 126/342 (37%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + + IL + VF +
Sbjct 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFE---DIYIEQRKTIRTILEYADKVFTYIF 1243
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + + D L+ V LV I+ Y S
Sbjct 1244 ILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---------------SE 1288
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+NL
Sbjct 1289 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
Query 601 FRGVIVALPGNSS-----LAPANGSAPCGSFEQLE----YWAN---NFDDFAAALVTLWN 648
F G +S + N C + W N NFD+ A + L
Sbjct 1349 FAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQ 1408
Query 649 LMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A P + IYFV++ + S +NLF+ +I++NF
Sbjct 1409 VATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1468
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1469 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510
Score = 131 bits (330), Expect = 5e-30, Method: Composition-based stats.
Identities = 60/334 (18%), Positives = 106/334 (32%), Gaps = 81/334 (24%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A + H F +I + +++ CVF+ ++ + F
Sbjct 119 NLIRRIAIKILIHSVFS----MIIMCTILTNCVFMTFSNPPDWSKN-------VEYTFTG 167
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + ++ + E L
Sbjct 168 IYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNL-------------- 213
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 214 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 266
Query 595 IIGINLFRG-----------------------------------VIVALPG--------- 610
+IG+ LF G +PG
Sbjct 267 LIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGN 326
Query 611 -NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+ + G + Y +FD F+ A + L+ LM + W+ R +G
Sbjct 327 SSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT 386
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
I+FVL V S VNL LA++ + +
Sbjct 387 YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
Score = 123 bits (308), Expect = 3e-27, Method: Composition-based stats.
Identities = 38/263 (14%), Positives = 93/263 (35%), Gaps = 34/263 (13%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P+ + + D +L +V +F+ ++ + + + +L + N VF
Sbjct 737 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGI 795
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM LK+ A+ Y N+FDG + + L+ L+
Sbjct 796 FTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------SLA 835
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 836 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 895
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF + +L W + DF + + ++ ++ +
Sbjct 896 LFGKSYKECVCKINQDC-----------ELPRWHMH--DFFHSFLIVFRVLCGEWIETMW 942
Query 660 DAYRRYSGPWSKIYFVLWWLVSS 682
D I F++ ++ +
Sbjct 943 DCMEVAGQAMCLIVFMMVMVIGN 965
Score = 99.4 bits (246), Expect = 7e-20, Method: Composition-based stats.
Identities = 51/317 (16%), Positives = 109/317 (34%), Gaps = 80/317 (25%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ + L ++F ++ + I T + + W +++VE ++
Sbjct 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFS----NPPDW------SKNVEYTFTGIYT 170
Query 138 ADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ VK G+ F ++ W V++++ + V +L LR R+LR
Sbjct 171 FESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFV--NLGNVSALRTFRVLRAL 228
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINF 288
Query 247 ---------------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD- 276
+ T F +P L L + NP+
Sbjct 289 NESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNY 348
Query 277 -----------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTA 309
+M Y +N + Y IFF++ +GS +L+NL+ A
Sbjct 349 GYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILA 408
Query 310 IIYSQFRGYLMKSLQTS 326
++ + +L+ +
Sbjct 409 VVAMAYEEQNQATLEEA 425
Score = 94.4 bits (233), Expect = 2e-18, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 77/179 (43%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SL++ +++ + LR R
Sbjct 789 NLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLA-DVEGLSVLRSFR 847
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 848 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 907
Query 249 RER-----LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + I F++ VIG+
Sbjct 908 INQDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 965
>sp|O88420|SCN8A_RAT Sodium channel protein type 8 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn8a PE=1 SV=1
Length=1978
Score = 546 bits (1406), Expect = 2e-172, Method: Composition-based stats.
Identities = 137/754 (18%), Positives = 276/754 (37%), Gaps = 95/754 (13%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
+ES+P + G T +V + + +D F E +Q
Sbjct 1113 SESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQV 1172
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+ C + F + I S + D+ + +
Sbjct 1173 NIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQ--RKTIRTIL 1230
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCH 181
E + + +F ++ +K +G+ F N W +++ VSLV L
Sbjct 1231 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1290
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1291 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1350
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDV--MIPAYSKNRAYAIFFIVFTVIG 299
+ + + N D ++ S + I F +G
Sbjct 1351 YHYCFNETSEI------------RFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVG 1398
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
+ +L L A F+G+ M + ++ R+ + +E M F +
Sbjct 1399 AGYLALLQVA----TFKGW-MDIMYAAVDSRKPDEQPDYEGNIYMYIY---FVIFIIFGS 1450
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQ 418
L + V +D+ ++Q K + G + EE +K +N + + K+ P P
Sbjct 1451 FFTLNLFIGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPL 1506
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ FD + ++ N+V+ ++++ D + ++ IL +N VF++
Sbjct 1507 NKIQGIVFDFVTQQAFDIVIMMLICLNMVT----MMVETDTQSKQMEN-ILYWINLVFVI 1561
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGL 537
++ E +LK+FAL Y + N+FD V+++L I + + + + P + +
Sbjct 1562 FFTCECVLKMFALR-HYYFTIGWNIFDF----VVVILSIVGMFLADIIEKYFVSPTLFRV 1616
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ L + R+L ++ + +R + +M + + G +L +V ++F+I G
Sbjct 1617 IRLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIFSIFG 1667
Query 598 INLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
++ F V + NF+ F +++ L+ + W
Sbjct 1668 MSNFAYVKHEAGIDDM--------------------FNFETFGNSMICLFQITTSAGWDG 1707
Query 658 FL--------DAYRRYSGPWS------------KIYFVLWWLVSSVIWVNLFLALILENF 697
L D P S +FV + ++S +I VN+++A+ILENF
Sbjct 1708 LLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1767
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + PL+ T+ E D +
Sbjct 1768 SVATEESAD--PLSEDDFETFYEIWEKFDPDATQ 1799
Score = 233 bits (594), Expect = 6e-63, Method: Composition-based stats.
Identities = 66/342 (19%), Positives = 123/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + + IL + VF +
Sbjct 1185 LRKTCFLIVEHNWFETFIIFMILLSSGALAFE---DIYIEQRKTIRTILEYADKVFTYIF 1241
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + + D L+ V LV I+ Y S
Sbjct 1242 ILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY---------------SE 1286
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+NL
Sbjct 1287 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1346
Query 601 FRGVIVALPGNSSL---------APANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWN 648
F G +S + W N NFD+ A + L
Sbjct 1347 FAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVGAGYLALLQ 1406
Query 649 LMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A P + IYFV++ + S +NLF+ +I++NF
Sbjct 1407 VATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1466
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1467 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1508
Score = 131 bits (328), Expect = 1e-29, Method: Composition-based stats.
Identities = 63/334 (19%), Positives = 106/334 (32%), Gaps = 81/334 (24%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A + H F +I + +++ CVF+ P E + F
Sbjct 119 NLIRRIAIKILIHSVFS----MIIMCTILTNCVFMTFS---NPPEWSKNV----EYTFTG 167
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + ++ V E L
Sbjct 168 IYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDL-------------- 213
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 214 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 266
Query 595 IIGINLFRG-----------------------------------VIVALPG--------- 610
+IG+ LF G +PG
Sbjct 267 LIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGN 326
Query 611 -NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+ + G + Y +FD F+ A + L+ LM + W+ R +G
Sbjct 327 SSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT 386
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
I+FVL V S VNL LA++ + +
Sbjct 387 YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
Score = 125 bits (315), Expect = 3e-28, Method: Composition-based stats.
Identities = 39/263 (15%), Positives = 93/263 (35%), Gaps = 34/263 (13%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P+ + + D +L +V +F+ ++ + + + +L + N VF
Sbjct 735 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGI 793
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM LK+ A+ Y N+FDG + + L+ L+
Sbjct 794 FTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL--------------------SLA 833
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 834 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 893
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
LF + +L W N DF + + ++ ++ +
Sbjct 894 LFGKSYKECVCKINQEC-----------KLPRWHMN--DFFHSFLIVFRVLCGEWIETMW 940
Query 660 DAYRRYSGPWSKIYFVLWWLVSS 682
D I F++ ++ +
Sbjct 941 DCMEVAGQAMCLIVFMMVMVIGN 963
Score = 99.4 bits (246), Expect = 6e-20, Method: Composition-based stats.
Identities = 52/317 (16%), Positives = 108/317 (34%), Gaps = 80/317 (25%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ + L ++F ++ + I T + + W +++VE ++
Sbjct 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFS----NPPEW------SKNVEYTFTGIYT 170
Query 138 ADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ VK G+ F ++ W V++++ V V L LR R+LR
Sbjct 171 FESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFV--DLGNVSALRTFRVLRAL 228
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINF 288
Query 247 ---------------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD- 276
+ T F +P L L + NP+
Sbjct 289 NESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNY 348
Query 277 -----------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTA 309
+M Y +N + Y IFF++ +GS +L+NL+ A
Sbjct 349 GYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILA 408
Query 310 IIYSQFRGYLMKSLQTS 326
++ + +L+ +
Sbjct 409 VVAMAYEEQNQATLEEA 425
Score = 94.0 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 77/179 (43%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SL++ +++ + LR R
Sbjct 787 NLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLA-DVEGLSVLRSFR 845
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 846 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 905
Query 249 RER-----LTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + I F++ VIG+
Sbjct 906 INQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 963
>sp|Q62205|SCN9A_MOUSE Sodium channel protein type 9 subunit alpha
OS=Mus musculus OX=10090 GN=Scn9a PE=1 SV=2
Length=1984
Score = 544 bits (1401), Expect = 1e-171, Method: Composition-based stats.
Identities = 128/694 (18%), Positives = 265/694 (38%), Gaps = 96/694 (14%)
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+D+ C R + + F + I S + D+ + +
Sbjct 1168 IDSGK-GKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKK--KTIKIIL 1224
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCH 181
E + + +F ++ +K +G+ + N W +++ VSLV L
Sbjct 1225 EYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPI 1284
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1285 KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1344
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGS 300
+++ + + S + AN + + S N + + F +G
Sbjct 1345 ------------FYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVG- 1391
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
+ L+ + + F+G+ M + ++ + + +E M F +
Sbjct 1392 ---LGYLSLLQVATFKGW-MDIMYAAVDSVNVNAQPIYEYNLYMYIY---FVIFIIFGSF 1444
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQS 419
L + V +D+ ++Q K + G + EE +K +N + + K+ P P +
Sbjct 1445 FTLNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1500
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
F L + FD ++ N+V++ V D + F+L +N VFI+
Sbjct 1501 KFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMS-----FVLYWINVVFIIL 1555
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+ +L Y + N+FD V+++L I + + + + P + ++
Sbjct 1556 FTGECVLKLISLR-HYYFTVGWNIFDF----VVVILSIVGMFLAEMIEKYFVSPTLFRVI 1610
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M + + G +L +V +++AI G+
Sbjct 1611 RLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGM 1661
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V N NF+ F +++ L+ + W
Sbjct 1662 SNFAYVKKEAGINDM--------------------FNFETFGNSMICLFQITTSAGWDGL 1701
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D + P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1702 LAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1761
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + +PL+ + E D +
Sbjct 1762 SVATEEST--EPLSEDDFEMFYEVWEKFDPDATQ 1793
Score = 236 bits (602), Expect = 5e-64, Method: Composition-based stats.
Identities = 66/334 (20%), Positives = 128/334 (38%), Gaps = 39/334 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ L+ L + ++ D + + IL + +F +
Sbjct 1179 IRKTCYRIVEHSWFESFIVLMILLSSGALAFE---DIYIEKKKTIKIILEYADKIFTYIF 1235
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + Y + D L+ V LV TL L + P
Sbjct 1236 ILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGYSDLGP-------- 1283
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+NL
Sbjct 1284 ---IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNL 1340
Query 601 FRGVIVALPGNS-----SLAPANGSAPCGSFEQL---EYWAN---NFDDFAAALVTLWNL 649
F G + S++ + C + + W N NFD+ ++L +
Sbjct 1341 FAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQV 1400
Query 650 MVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
W + A + IYFV++ + S +NLF+ +I++NF
Sbjct 1401 ATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1460
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ + Y ++ L ++P
Sbjct 1461 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1494
Score = 140 bits (352), Expect = 1e-32, Method: Composition-based stats.
Identities = 58/348 (17%), Positives = 111/348 (32%), Gaps = 80/348 (23%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP + + + H F ++ + +++ C+F+ + + + F
Sbjct 113 SPLRRISIKILVHSLFS----MLIMCTILTNCIFMTMSNPPDWTKN-------VEYTFTG 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D ++ V + E L
Sbjct 162 IYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
+IG+ LF G +
Sbjct 261 LIGLQLFMGNLKHKCFRKDLEQNETLESIMSTAESEEELKRYFYYLEGSKDALLCGFSTD 320
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
S G + +Y +FD F A + L+ LM + W+ R +G I
Sbjct 321 SGQCPEGYECVTAGRNPDYGYTSFDTFGWAFLALFRLMTQDYWENLYQQTLRAAGKTYMI 380
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
+FV+ + S +NL LA++ ++ +++++ QM
Sbjct 381 FFVVVIFLGSFYLINLILAVV--AMAYEEQNQANIEEAKQKELEFQQM 426
Score = 120 bits (300), Expect = 2e-26, Method: Composition-based stats.
Identities = 41/264 (16%), Positives = 94/264 (36%), Gaps = 34/264 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP+ + D +L +V +F+ ++ + E + +L + N VF
Sbjct 726 SPYWIKFKKFIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTDEFKN-VLAVGNLVFTG 784
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ A+ Y N+FD L+ + LV L
Sbjct 785 IFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVEL--------------------FL 824
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 825 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 884
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF + +L W N DF + + ++ ++ +
Sbjct 885 QLFGKSYKECVCKINENC-----------KLPRWHMN--DFFHSFLIVFRVLCGEWIETM 931
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D I +++ ++ +
Sbjct 932 WDCMEVAGQTMCLIVYMMVMVIGN 955
Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats.
Identities = 52/322 (16%), Positives = 106/322 (33%), Gaps = 77/322 (24%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ + L ++F +L + I T + + W T++VE ++
Sbjct 116 RRISIKILVHSLFSMLIMCTILTNCIFMTMS----NPPDW------TKNVEYTFTGIYTF 165
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ +K G+ F ++ W VV+V T ++L LR R+LR
Sbjct 166 ESLIKILARGFCVGEFTFLRDPWNWLDFVVIV--FAYLTEFVNLGNVSALRTFRVLRALK 223
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ +K + + S+ +++ V +L L +F + G+ LF G + ++
Sbjct 224 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQN 283
Query 255 ---------------------------------FQNLPESLTSLLVLLTTANNPD----- 276
F +T NPD
Sbjct 284 ETLESIMSTAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTS 343
Query 277 -------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
+M Y +N + Y IFF+V +GS +L+NL+ A++
Sbjct 344 FDTFGWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAM 403
Query 314 QFRGYLMKSLQTSLFRRRLGTR 335
+ +++ + + +
Sbjct 404 AYEEQNQANIEEAKQKELEFQQ 425
Score = 92.9 bits (229), Expect = 7e-18, Method: Composition-based stats.
Identities = 31/158 (20%), Positives = 68/158 (43%), Gaps = 7/158 (4%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +FAA++ +K + + W + +++ +SLV+ ++ + LR R
Sbjct 779 NLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA-DVEGLSVLRSFR 837
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 838 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 897
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + + S + +L + M
Sbjct 898 INENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDC 934
>sp|O08562|SCN9A_RAT Sodium channel protein type 9 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn9a PE=1 SV=1
Length=1984
Score = 543 bits (1398), Expect = 3e-171, Method: Composition-based stats.
Identities = 128/694 (18%), Positives = 265/694 (38%), Gaps = 96/694 (14%)
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
VD+ C R + + F + I S + D+ + +
Sbjct 1168 VDSGK-GKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKK--KTIKIIL 1224
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCH 181
E + + +F ++ +K +G+ + N W +++ VSLV L
Sbjct 1225 EYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPI 1284
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1285 KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1344
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGS 300
+++ + + S AN + + S N + + F +G
Sbjct 1345 ------------FYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVG- 1391
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
+ L+ + + F+G+ M + ++ + + +E M F +
Sbjct 1392 ---LGYLSLLQVATFKGW-MDIMYAAVDSVNVNEQPKYEYSLYMYIY---FVIFIIFGSF 1444
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQS 419
L + V +D+ ++Q K + G + EE +K +N + + K+ P P +
Sbjct 1445 FTLNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN 1500
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
F L + FD ++ N+V++ V + + D++L +N VFI+
Sbjct 1501 KFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTEYM-----DYVLHWINMVFIIL 1555
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLL 538
+ E +LK+ +L Y + N+FD V+++L I + + + + P + ++
Sbjct 1556 FTGECVLKLISLR-HYYFTVGWNIFDF----VVVILSIVGMFLAEMIEKYFVSPTLFRVI 1610
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
L + R+L ++ + +R + +M + + G +L +V +++AI G+
Sbjct 1611 RLARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGM 1661
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+ F V N NF+ F +++ L+ + W
Sbjct 1662 SNFAYVKKEAGINDM--------------------FNFETFGNSMICLFQITTSAGWDGL 1701
Query 659 L---------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENF 697
L D + P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1702 LAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1761
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + +PL+ + E D +
Sbjct 1762 SVATEEST--EPLSEDDFEMFYEVWEKFDPDATQ 1793
Score = 236 bits (601), Expect = 6e-64, Method: Composition-based stats.
Identities = 65/334 (19%), Positives = 126/334 (38%), Gaps = 39/334 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ L+ L + ++ D + + IL + +F +
Sbjct 1179 IRKTCYRIVEHSWFESFIVLMILLSSGALAFE---DIYIEKKKTIKIILEYADKIFTYIF 1235
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LEMLLK A G + Y + D L+ V LV TL L + P
Sbjct 1236 ILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLV----TLVANTLGYSDLGP-------- 1283
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV + ++G + ++ + ++ + +F+I+G+NL
Sbjct 1284 ---IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNL 1340
Query 601 FRGVIVALPGNSS-----LAPANGSAPCGSFEQL---EYWAN---NFDDFAAALVTLWNL 649
F G + + + C + + W N NFD+ ++L +
Sbjct 1341 FAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQV 1400
Query 650 MVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
W + A + IYFV++ + S +NLF+ +I++NF
Sbjct 1401 ATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1460
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ + Y ++ L ++P
Sbjct 1461 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1494
Score = 140 bits (352), Expect = 1e-32, Method: Composition-based stats.
Identities = 61/348 (18%), Positives = 113/348 (32%), Gaps = 80/348 (23%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP + + + H F ++ + +++ C+F+ L P E + F
Sbjct 113 SPLRRISIKILVHSLFS----MLIMCTILTNCIFMTLS---NPPEWTKNV----EYTFTG 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D ++ V + E L
Sbjct 162 IYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
+IG+ LF G +
Sbjct 261 LIGLQLFMGNLKHKCFRKELEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTD 320
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
S G + +Y +FD F+ A + L+ LM + W+ R +G I
Sbjct 321 SGQCPEGYICVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMI 380
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
+FV+ + S +NL LA++ ++ +++++ QM
Sbjct 381 FFVVVIFLGSFYLINLILAVV--AMAYEEQNQANIEEAKQKELEFQQM 426
Score = 120 bits (300), Expect = 2e-26, Method: Composition-based stats.
Identities = 40/264 (15%), Positives = 96/264 (36%), Gaps = 34/264 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP+ + L D +L +V +F+ ++ + E + +L + N +F
Sbjct 726 SPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN-VLAVGNLIFTG 784
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ A+ Y N+FD L+ + L+ L
Sbjct 785 IFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIEL--------------------FL 824
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 825 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 884
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF ++ +L W N DF + + ++ ++ +
Sbjct 885 QLFGKSYKECVCKINVDC-----------KLPRWHMN--DFFHSFLIVFRVLCGEWIETM 931
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D I +++ ++ +
Sbjct 932 WDCMEVAGQTMCLIVYMMVMVIGN 955
Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats.
Identities = 56/322 (17%), Positives = 111/322 (34%), Gaps = 77/322 (24%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ + L ++F +L + I T + + W T++VE ++
Sbjct 116 RRISIKILVHSLFSMLIMCTILTNCIFMTLS----NPPEW------TKNVEYTFTGIYTF 165
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ +K G+ F ++ W VV+V T ++L LR R+LR
Sbjct 166 ESLIKILARGFCVGEFTFLRDPWNWLDFVVIV--FAYLTEFVNLGNVSALRTFRVLRALK 223
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G +
Sbjct 224 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKELEEN 283
Query 247 -----------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD----- 276
+ E YF L S +L + + NPD
Sbjct 284 ETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDYGYTS 343
Query 277 -------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
+M Y +N + Y IFF+V +GS +L+NL+ A++
Sbjct 344 FDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAM 403
Query 314 QFRGYLMKSLQTSLFRRRLGTR 335
+ +++ + + +
Sbjct 404 AYEEQNQANIEEAKQKELEFQQ 425
Score = 92.9 bits (229), Expect = 7e-18, Method: Composition-based stats.
Identities = 38/184 (21%), Positives = 75/184 (41%), Gaps = 25/184 (14%)
Query 115 AAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV 174
E + ++ +FAA++ +K + + W + +++ +SL++ +
Sbjct 765 HPMTEEFKNVLAVGNLIFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFL 824
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
+ + LR RLLR F L ++ + +K I S+ + ++ L+LAI + +F + G
Sbjct 825 A-DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 883
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
M LF G + + N D +P + N + F IV
Sbjct 884 MQLF-GKSYKECVCKI-----------------------NVDCKLPRWHMNDFFHSFLIV 919
Query 295 FTVI 298
F V+
Sbjct 920 FRVL 923
>sp|Q2XVR3|SC4AA_DANRE Sodium channel protein type 4 subunit alpha
A OS=Danio rerio OX=7955 GN=scn4aa PE=2 SV=2
Length=1829
Score = 540 bits (1390), Expect = 6e-171, Method: Composition-based stats.
Identities = 129/702 (18%), Positives = 273/702 (39%), Gaps = 105/702 (15%)
Query 72 WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
C + F + I S + D+ + E + +
Sbjct 980 GKKWWNLRRTCFTIVEHDYFETFIIFMILLSSGALAFEDI--NIERRRVIKTILEYADKV 1037
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIR 187
+F ++ +K +G+ + N W +++ VSLV T +L L + LR
Sbjct 1038 FTYIFIVEMLLKWVAYGFKTYFTNAWCWLDFLIVDVSLVSLTANLMGYSELGAIKSLRTL 1097
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1098 RALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGK------ 1151
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
++ + + + + N D M Y+ + + + +G + L
Sbjct 1152 ------FYHCINTTTEERIPMDVVNNKSDCMALMYTNEVRWVNVKVNYDNVG----LGYL 1201
Query 308 TAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
+ + + F+G+ M + ++ R + + ++E+ M F + L +
Sbjct 1202 SLLQIATFKGW-MDIMYAAVDSREVDEQPSYEINLYMYLY---FVIFIIFGSFFTLNLFI 1257
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP-PRPEYQSPFLQSAQ 426
V +D+ ++Q K + G + EE +K +N + + K+ P P P +
Sbjct 1258 GVIIDNFNQQ----KSKFGGKDIFMTEEQKKYYNAMKKLGAKKRPKPIPRPSNIIQGLVF 1313
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
+FD ++ N+V+ ++++ D AE+ +++L +N VFIV + E +L
Sbjct 1314 DFISKQFFDIFIMVLICLNMVT----MMIETDDQSAEK-EYVLYQINLVFIVVFTSECVL 1368
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTR 545
K+FAL + + + NVFD V+++L I+ L + + + P + ++ L + R
Sbjct 1369 KLFALR-QYFFTIGWNVFDF----VVVILSIAGLMLSDIIEKYFVSPTLFRVIRLARIGR 1423
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+L ++ + +R + +M + + G +L ++ ++F+I G++ F V
Sbjct 1424 VLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSNFAYVK 1474
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL------ 659
+ NF+ F +++ L+ + W L
Sbjct 1475 KQAGIDD--------------------IFNFETFGGSIICLFEITTSAGWDGLLLPILNS 1514
Query 660 ---DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDPR 704
D + P + + +F + ++S ++ VN+++A+ILENF + +
Sbjct 1515 GPPDCDPDFENPGTDVRGNCGNPGMGIMFFCSYIIMSFLVVVNMYIAIILENFNNAQEES 1574
Query 705 SHLQPLAG-----------TPEATYQMTVELLFR--DILEEP 733
+AT + + LF D L+EP
Sbjct 1575 GDPLCEDDFDMFDETWEKFDVDATQFIEYDRLFDFVDALQEP 1616
Score = 134 bits (337), Expect = 8e-31, Method: Composition-based stats.
Identities = 74/477 (16%), Positives = 158/477 (33%), Gaps = 79/477 (17%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + N + +L L+T ++ + Y IFF+V +GS +L+NL+ A
Sbjct 352 GYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIFFVVVIFLGSFYLINLILA 411
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF----PQAVGVKPQNLLQV 365
++ + +L + + R ++ + G + Q+ G L
Sbjct 412 VVAMAYDEQNEATLAEARDKEEEFQRLLEQLKNQETGSKASLASQKTQSRGSNRTGSLHD 471
Query 366 LQKVQLDSSHKQAMMEKV---RSYGSVLLSAEEFQKLFNE------LDRSVVKEH----- 411
L + ++ ++ R + LSAEE QK + LD+ + +
Sbjct 472 LADEDVIKDCNGRIVPRLIVNRVSSNKELSAEEDQKSLSSKHSMQYLDQPKLSKRTASAL 531
Query 412 ------------PPRPEYQSPFLQSAQFL--------------FGHYYFDYLGNLIALAN 445
RP + + FL D +L
Sbjct 532 SVLTATMEGLEDAQRPCPPGWYKFADMFLKWDCCAPWILFKKWVHFVVMDPFVDLGITIC 591
Query 446 LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
+V +F+ ++ + + +L + N VF + EM+ K+ A+ Y N+FD
Sbjct 592 IVLNTLFMAME-HYPMSPHFEHVLSVGNLVFTGIFTAEMVFKLIAMDPYYYFQVGWNIFD 650
Query 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
++ + LV L+ +L + R ++ S +
Sbjct 651 SIIVTLSLVEL--------------------GLANVQGLSVLRSFRLLRVFKLAKSWPTL 690
Query 566 AVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGS 625
++ + V + +L ++ ++FA++G+ LF
Sbjct 691 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVC-----------KISE 739
Query 626 FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS 682
+L W N DF + + ++ ++ + D I F++ ++ +
Sbjct 740 DCELPRWHMN--DFFHSFLIVFRILCGEWIETMWDCMEVAGASMCLIVFMMVMVIGN 794
Score = 122 bits (306), Expect = 4e-27, Method: Composition-based stats.
Identities = 59/343 (17%), Positives = 104/343 (30%), Gaps = 92/343 (27%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
+ A + H F + L+N CVF+ + ++ + VF Y
Sbjct 113 VRRGAIKILIHSLFSMFIMITILSN----CVFMTMSNPPAWSKT-------VEYVFTGIY 161
Query 481 LLEMLLKVFA----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVG 536
E +KV + +G +L P N D ++ + V E L
Sbjct 162 TFEATVKVLSRGFCIGPFTFLRDPWNWLDFMVISMAYVTEFVDL---------------- 205
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
L V R L+ I + + + ++ V+ M + + VFA+I
Sbjct 206 -----GNVSALRTFRVLRALKTITVIPGLKTIVGALIQSVKKMIDVMILTIFALAVFALI 260
Query 597 GINLFRG-----VIVALPGNSSLAPANGSAPCGSFEQLEYWANNF--------------- 636
G+ LF G I NS++ S +F
Sbjct 261 GLQLFMGNLRQKCIRWPILNSTIFDVYNSNMVNDTTLNVTDTFDFKAYINNEENQYFLEG 320
Query 637 ------------------------------------DDFAAALVTLWNLMVVNNWQVFLD 660
D+F A + L+ LM + W+
Sbjct 321 SLDALLCGNSSDAGRCPEGYTCMKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQ 380
Query 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
R +G I+FV+ + S +NL LA++ + + +
Sbjct 381 LTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYDEQNEA 423
Score = 96.3 bits (238), Expect = 5e-19, Method: Composition-based stats.
Identities = 37/211 (18%), Positives = 78/211 (37%), Gaps = 18/211 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F + + I + + + W +++VE + ++ + +VK
Sbjct 119 KILIHSLFSMFIMITILSNCVFMTMS----NPPAW------SKTVEYVFTGIYTFEATVK 168
Query 144 ----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ G F ++ W +V +S+ T + L LR R+LR +
Sbjct 169 VLSRGFCIGPFTFLRDPWNWLDFMV--ISMAYVTEFVDLGNVSALRTFRVLRALKTITVI 226
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD--RERLTYFQN 257
+K + + S+ +M V +L L +F + G+ LF G + T F
Sbjct 227 PGLKTIVGALIQSVKKMIDVMILTIFALAVFALIGLQLFMGNLRQKCIRWPILNSTIFDV 286
Query 258 LPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
++ + L T +N+ +
Sbjct 287 YNSNMVNDTTLNVTDTFDFKAYINNEENQYF 317
Score = 95.2 bits (235), Expect = 1e-18, Method: Composition-based stats.
Identities = 37/179 (21%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ K ++ + W + +++ +SLV+ ++ ++ LR R
Sbjct 618 NLVFTGIFTAEMVFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLA-NVQGLSVLRSFR 676
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 677 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 736
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIVFTVIGS 300
+ + S + +L + M A I F++ VIG+
Sbjct 737 ISEDCELPRWHMNDFFHSFLIVFRILCGE-WIETMWDCMEVAGASMCLIVFMMVMVIGN 794
>sp|P04774|SCN1A_RAT Sodium channel protein type 1 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn1a PE=1 SV=1
Length=2009
Score = 542 bits (1396), Expect = 1e-170, Method: Composition-based stats.
Identities = 126/697 (18%), Positives = 263/697 (38%), Gaps = 95/697 (14%)
Query 72 WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
C R + F + I S + D+ + + E + +
Sbjct 1201 GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQ--RKTIKTMLEYADKV 1258
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIR 187
+F ++ +K +G+ + N W +++ VSLV T L + LR
Sbjct 1259 FTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTL 1318
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1319 RALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK------ 1372
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNL 306
++ + + + N+ D + ++ + + F +G
Sbjct 1373 ------FYHCVNTTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGF----GY 1422
Query 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
L+ + + F+G+ M + ++ R + + +E M F + L +
Sbjct 1423 LSLLQVATFKGW-MDIMYAAVDSRNVELQPKYEESLYMYLY---FVIFIIFGSFFTLNLF 1478
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSA 425
V +D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1479 IGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMV 1534
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
FD ++ N+V++ V +D + + IL +N VFIV + E +
Sbjct 1535 FDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTS-----ILSRINLVFIVLFTGECV 1589
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMT 544
LK+ +L Y + N+FD V+++L I + + L + P + ++ L +
Sbjct 1590 LKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIG 1644
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
R+L ++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1645 RILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1695
Query 605 IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----- 659
+ + NF+ F +++ L+ + W L
Sbjct 1696 KREVGIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILN 1735
Query 660 ----DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1736 SKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1795
Query 704 RSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+PL+ + E D + ++L++
Sbjct 1796 --SAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQ 1830
Score = 127 bits (319), Expect = 1e-28, Method: Composition-based stats.
Identities = 41/262 (16%), Positives = 91/262 (35%), Gaps = 34/262 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP+ + + D +L +V +F+ ++ E + +L + N VF
Sbjct 751 SPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTEHFNHVLTVGNLVFTG 809
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM LK+ A+ Y N+FDG + + LV L
Sbjct 810 IFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVEL--------------------GL 849
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 850 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 909
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF + +L W N DF + + ++ ++ +
Sbjct 910 QLFGKSYKDCVC-----------KIATDCKLPRWHMN--DFFHSFLIVFRVLCGEWIETM 956
Query 659 LDAYRRYSGPWSKIYFVLWWLV 680
D F++ ++
Sbjct 957 WDCMEVAGQAMCLTVFMMVMVI 978
Score = 115 bits (287), Expect = 9e-25, Method: Composition-based stats.
Identities = 62/371 (17%), Positives = 113/371 (30%), Gaps = 99/371 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ + + + F
Sbjct 115 NPLRKIAIKILVHSLFS----MLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 164 IYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRG-----VIVALPGNSSLAPANGSAPCGS------------------FEQLEY 631
+IG+ LF G + P N+SL + + + Q
Sbjct 263 LIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWKSYIQDSR 322
Query 632 WANNFDDFAAALVT--------------------------------------LWNLMVVN 653
+ + AL+ L+ LM +
Sbjct 323 YHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQD 382
Query 654 NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGT 713
W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 383 FWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQK 440
Query 714 PEATYQMTVEL 724
QM +L
Sbjct 441 EAEFQQMLEQL 451
Score = 95.2 bits (235), Expect = 1e-18, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 65/167 (39%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V ++ T + L LR R+LR +
Sbjct 173 IIARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFVDLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
Score = 92.5 bits (228), Expect = 7e-18, Method: Composition-based stats.
Identities = 31/158 (20%), Positives = 68/158 (43%), Gaps = 7/158 (4%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SLV+ ++ ++ LR R
Sbjct 804 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLA-NVEGLSVLRSFR 862
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 863 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 922
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + + S + +L + M
Sbjct 923 IATDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDC 959
Score = 38.9 bits (89), Expect = 0.24, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 361 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 420
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 421 VVAMAYEEQNQATLEEA-EQKEAEFQ 445
>sp|A2APX8|SCN1A_MOUSE Sodium channel protein type 1 subunit alpha
OS=Mus musculus OX=10090 GN=Scn1a PE=1 SV=1
Length=2009
Score = 542 bits (1395), Expect = 1e-170, Method: Composition-based stats.
Identities = 126/697 (18%), Positives = 264/697 (38%), Gaps = 95/697 (14%)
Query 72 WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
C R + F + I S + D+ + + E + +
Sbjct 1201 GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQ--RKTIKTMLEYADKV 1258
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIR 187
+F ++ +K +G+ + N W +++ VSLV T L + LR
Sbjct 1259 FTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTL 1318
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1319 RALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK------ 1372
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNL 306
++ + + + + N+ D + ++ + + F +G
Sbjct 1373 ------FYHCVNTTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGF----GY 1422
Query 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
L+ + + F+G+ M + ++ R + + +E M F + L +
Sbjct 1423 LSLLQVATFKGW-MDIMYAAVDSRNVELQPKYEESLYMYLY---FVIFIIFGSFFTLNLF 1478
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSA 425
V +D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1479 IGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMV 1534
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
FD ++ N+V++ V +D + + IL +N VFIV + E +
Sbjct 1535 FDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTS-----ILSRINLVFIVLFTGECV 1589
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMT 544
LK+ +L Y + N+FD V+++L I + + L + P + ++ L +
Sbjct 1590 LKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIG 1644
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
R+L ++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1645 RILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1695
Query 605 IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----- 659
+ + NF+ F +++ L+ + W L
Sbjct 1696 KREVGIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILN 1735
Query 660 ----DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1736 SKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1795
Query 704 RSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+PL+ + E D + ++L++
Sbjct 1796 --SAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQ 1830
Score = 129 bits (325), Expect = 2e-29, Method: Composition-based stats.
Identities = 41/264 (16%), Positives = 92/264 (35%), Gaps = 34/264 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP+ + + D +L +V +F+ ++ E + +L + N VF
Sbjct 751 SPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTEHFNHVLTVGNLVFTG 809
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM LK+ A+ Y N+FDG + + LV L
Sbjct 810 IFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVEL--------------------GL 849
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 850 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 909
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF + +L W N DF + + ++ ++ +
Sbjct 910 QLFGKSYKDCVC-----------KIATDCKLPRWHMN--DFFHSFLIVFRVLCGEWIETM 956
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D F++ ++ +
Sbjct 957 WDCMEVAGQAMCLTVFMMVMVIGN 980
Score = 114 bits (286), Expect = 1e-24, Method: Composition-based stats.
Identities = 63/371 (17%), Positives = 113/371 (30%), Gaps = 99/371 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ + + + F
Sbjct 115 NPLRKIAIKILVHSLFS----MLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 164 IYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRG-----VIVALPGNSSLAPANGSAPC------------------GSFEQLEY 631
+IG+ LF G + P N+SL + S+ Q
Sbjct 263 LIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSR 322
Query 632 WANNFDDFAAALVT--------------------------------------LWNLMVVN 653
+ + AL+ L+ LM +
Sbjct 323 YHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQD 382
Query 654 NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGT 713
W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 383 FWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQK 440
Query 714 PEATYQMTVEL 724
QM +L
Sbjct 441 EAEFQQMLEQL 451
Score = 94.8 bits (234), Expect = 1e-18, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 65/167 (39%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V ++ T + L LR R+LR +
Sbjct 173 IIARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFVDLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
Score = 93.3 bits (230), Expect = 5e-18, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SLV+ ++ ++ LR R
Sbjct 804 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLA-NVEGLSVLRSFR 862
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 863 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 922
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + F++ VIG+
Sbjct 923 IATDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 980
Score = 38.9 bits (89), Expect = 0.25, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 361 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 420
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 421 VVAMAYEEQNQATLEEA-EQKEAEFQ 445
>sp|P35499|SCN4A_HUMAN Sodium channel protein type 4 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN4A PE=1 SV=4
Length=1836
Score = 538 bits (1387), Expect = 2e-170, Method: Composition-based stats.
Identities = 127/706 (18%), Positives = 265/706 (38%), Gaps = 105/706 (15%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + + F + I S + D+ + E
Sbjct 1010 SQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RRVIRTILEY 1067
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD----WTVSLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VS++ W L +
Sbjct 1068 ADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKS 1127
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1128 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK-- 1185
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
++ + + + + N + ++ + + + +G
Sbjct 1186 ----------FYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVG---- 1231
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ M + ++ R + +EV M F + L
Sbjct 1232 LGYLSLLQVATFKGW-MDIMYAAVDSREKEEQPQYEVNLYMYLY---FVIFIIFGSFFTL 1287
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P Q+
Sbjct 1288 NLFIGVIIDNFNQQ----KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1343
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
L FD ++ N+V+ ++++ D + D IL +N +FI+ +
Sbjct 1344 GMVYDLVTKQAFDITIMILICLNMVT----MMVETDNQSQLKVD-ILYNINMIFIIIFTG 1398
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK+ AL + Y + N+FD V+++L I LA+ L + P + ++ L
Sbjct 1399 ECVLKMLALR-QYYFTVGWNIFDF----VVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1453
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L +V ++++I G++ F
Sbjct 1454 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGMSNF 1504
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1505 AYVKKESGIDDM--------------------FNFETFGNSIICLFEITTSAGWDGLLNP 1544
Query 660 -------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHK 700
D P + + +F + ++S +I VN+++A+ILENF
Sbjct 1545 ILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVA 1604
Query 701 WDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
+ S P+AT + L F D L+EP
Sbjct 1605 TEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEP 1650
Score = 137 bits (346), Expect = 6e-32, Method: Composition-based stats.
Identities = 60/444 (14%), Positives = 143/444 (32%), Gaps = 50/444 (11%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + + +L L+T ++ + Y IFF+V +GS +L+NL+ A
Sbjct 385 GYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILA 444
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + + +L + ++L +A + +
Sbjct 445 VVAMAYAEQN----EATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDP 500
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF-- 427
++ G+ S+ + + ++ P + + +
Sbjct 501 AHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNC 560
Query 428 ---------LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ D +L +V +F+ ++ E D +L + N VF
Sbjct 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAME-HYPMTEHFDNVLTVGNLVFTG 619
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ A+ Y N+FD ++ + LV L
Sbjct 620 IFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVEL--------------------GL 659
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 660 ANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 719
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF +L L W + DF + + ++ ++ +
Sbjct 720 QLFGKSYKECVCKIALDC-----------NLPRWHMH--DFFHSFLIVFRILCGEWIETM 766
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D F++ ++ +
Sbjct 767 WDCMEVAGQAMCLTVFLMVMVIGN 790
Score = 99.0 bits (245), Expect = 8e-20, Method: Composition-based stats.
Identities = 32/178 (18%), Positives = 66/178 (37%), Gaps = 16/178 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L +F + + I T + +D PW +++VE ++ + +K
Sbjct 126 KVLIHALFSMFIMITILTNCVFMTMSDP----PPW------SKNVEYTFTGIYTFESLIK 175
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V++ + T + L LR R+LR +
Sbjct 176 ILARGFCVDDFTFLRDPWNWLDFSVIM--MAYLTEFVDLGNISALRTFRVLRALKTITVI 233
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQN 257
+K + + S+ +++ V +L L +F + G+ LF G + N
Sbjct 234 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTN 291
Score = 97.5 bits (241), Expect = 2e-19, Method: Composition-based stats.
Identities = 35/180 (19%), Positives = 75/180 (42%), Gaps = 11/180 (6%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K + + W + +++ +SLV+ ++ ++ LR R
Sbjct 614 NLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLA-NVQGLSVLRSFR 672
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-- 246
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF G +
Sbjct 673 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVC 731
Query 247 ----QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + S + +L + M + F++ VIG+
Sbjct 732 KIALDCNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 790
Score = 91.7 bits (226), Expect = 1e-17, Method: Composition-based stats.
Identities = 39/229 (17%), Positives = 73/229 (32%), Gaps = 39/229 (17%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
S + A + H F + L N CVF+ + ++ + F
Sbjct 118 SVVRRGAIKVLIHALFSMFIMITILTN----CVFMTMSDPPPWSKN-------VEYTFTG 166
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + ++ + E L
Sbjct 167 IYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL-------------- 212
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 213 -------GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 265
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
++G+ LF G + P + ++ + W N + +
Sbjct 266 LVGLQLFMGNLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEM 311
Score = 69.4 bits (168), Expect = 1e-10, Method: Composition-based stats.
Identities = 23/128 (18%), Positives = 47/128 (37%), Gaps = 4/128 (3%)
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
G + Y ++D F+ A + L+ LM + W+ R +G I+FV
Sbjct 369 CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFV 428
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGE 735
+ + S +NL LA++ + + + + + F+ EE +
Sbjct 429 VIIFLGSFYLINLILAVVAMAYAEQNEA----TLAEDKEKEEEFQQMLEKFKKHQEELEK 484
Query 736 DELTERLS 743
+ + L
Sbjct 485 AKAAQALE 492
>sp|Q9Y5Y9|SCNAA_HUMAN Sodium channel protein type 10 subunit
alpha OS=Homo sapiens OX=9606 GN=SCN10A PE=1 SV=2
Length=1956
Score = 537 bits (1384), Expect = 2e-169, Method: Composition-based stats.
Identities = 140/720 (19%), Positives = 269/720 (37%), Gaps = 98/720 (14%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
F E I++ S W C R + + F + I S + D
Sbjct 1115 FTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDY 1174
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
P L E + + +F ++ +K +G+ + N W +++ +SL+
Sbjct 1175 YLDQKP--TVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLIS 1232
Query 172 WTV----SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
T + + LR R LRP L M+ + + ++P + +V L+ I
Sbjct 1233 LTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFW 1292
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
+F++ G+ LFAG N + SL+ L N D I + +
Sbjct 1293 LIFSIMGVNLFAGKF----------WRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFF 1342
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGE 347
+ + F + M L + + F+G+ M + ++ R + + +E M
Sbjct 1343 WVNVKVNFDNV----AMGYLALLQVATFKGW-MDIMYAAVDSREVNMQPKWEDNVYMYLY 1397
Query 348 GGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSV 407
F G L + V +D+ ++Q K + G + EE +K +N + +
Sbjct 1398 FVIFIIFGG---FFTLNLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLG 1450
Query 408 VKEH-PPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
K+ P P + F + FD ++ N+++ ++++ D E+
Sbjct 1451 SKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMIT----MMVETDDQSEEKTK 1506
Query 467 FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLP 526
ILG +N F+ + E ++K+FAL + Y + NVFD + VVL + + A+ +
Sbjct 1507 -ILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDF-IVVVLSIASLIFSAILKSL 1563
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGIL 586
+ P + ++ L + R+L ++ + +R + +M + + G +L
Sbjct 1564 QSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMM---------SLPALFNIGLLL 1614
Query 587 VVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTL 646
+V ++++I G++ F P +E NF FA +++ L
Sbjct 1615 FLVMFIYSIFGMSSF--------------------PHVRWEAGIDDMFNFQTFANSMLCL 1654
Query 647 WNLMVVNNWQVFLDAYRRYSGPWSK--------------------IYFVLWWLVSSVIWV 686
+ + W L P+ I+F + ++S +I V
Sbjct 1655 FQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMV 1714
Query 687 NLFLALILENFLHKWDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
N+++A+ILENF + + PEAT +T L F D L P
Sbjct 1715 NMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGP 1774
Score = 230 bits (586), Expect = 5e-62, Method: Composition-based stats.
Identities = 62/342 (18%), Positives = 123/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + S+ D + +L + VF +
Sbjct 1141 VRKTCYRIVEHSWFESFIIFMILLSSGSLAFE---DYYLDQKPTVKALLEYTDRVFTFIF 1197
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+ EMLLK A G + Y + D L+ + L+ + + Y P
Sbjct 1198 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAP------------ 1245
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV ++G + ++ + ++ + +F+I+G+NL
Sbjct 1246 ---IKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1302
Query 601 FRGVIVALPGNSS-------LAPANGSAPCGSFEQLE--YWAN---NFDDFAAALVTLWN 648
F G + L+ N + C +W N NFD+ A + L
Sbjct 1303 FAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQ 1362
Query 649 LMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A + +YFV++ + +NLF+ +I++NF
Sbjct 1363 VATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFN 1422
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1423 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1464
Score = 150 bits (378), Expect = 8e-36, Method: Composition-based stats.
Identities = 64/350 (18%), Positives = 118/350 (34%), Gaps = 78/350 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A + H +F + L N V + + + VF V
Sbjct 117 NLIRRTAIKVSVHSWFSLFITVTILVNCVCM--------------TRTDLPEKIEYVFTV 162
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G YL P N D + + V L
Sbjct 163 IYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDL-------------- 208
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ + + + V+ ++ V+ + + + VFA
Sbjct 209 -------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFA 261
Query 595 IIGINLFRGVIVALP------------------------------------GNSSLAPAN 618
++G+ LF+G + G+ S +
Sbjct 262 LVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPD 321
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWW 678
G + + ++ +FD FA A ++L+ LM ++W+ R SG I+FVL
Sbjct 322 GYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVI 381
Query 679 LVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
+ S VNL LA++ + + + E +Q +E+L ++
Sbjct 382 FLGSFYLVNLILAVVTMAYEEQNQATTD---EIEAKEKKFQEALEMLRKE 428
Score = 127 bits (320), Expect = 8e-29, Method: Composition-based stats.
Identities = 49/281 (17%), Positives = 102/281 (36%), Gaps = 35/281 (12%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + + D L +V +F+ ++ + + +L I N VF ++
Sbjct 649 PMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSP-TFEAMLQIGNIVFTIF 707
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ EM+ K+ A Y N+FD ++ V L+ ++
Sbjct 708 FTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL--------------------GVA 747
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+L + R ++ S + + + V + IL ++ +VFA++G
Sbjct 748 KKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQ 807
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
L N N SAP + + DF + + ++ ++ W +
Sbjct 808 LLG-------ENYRNNRKNISAPHEDWPRWHMH-----DFFHSFLIVFRILCGE-WIENM 854
Query 660 DAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
A I F+ ++ +++ +NLF+AL+L +F
Sbjct 855 WACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSA 895
Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats.
Identities = 52/345 (15%), Positives = 113/345 (33%), Gaps = 66/345 (19%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLV 179
L E +E + +++ + +K G+ + ++ W V ++L ++ L
Sbjct 152 LPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSV--ITLAYVGTAIDLR 209
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR R+LR + +K + + S+ ++A V +L L +F + G+ LF
Sbjct 210 GISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFK 269
Query 240 GGKQDDGQDRERLTY-------------FQNLPESLTSL--------------LVLLTTA 272
G ++ + + N + L + L T+
Sbjct 270 GNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTS 329
Query 273 NNPDVMIPAYSKNRA----------------------------YAIFFIVFTVIGSLFLM 304
+NPD ++ Y IFF++ +GS +L+
Sbjct 330 DNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLV 389
Query 305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF-PQAVGVKPQNLL 363
NL+ A++ + Q + + E L + E + +
Sbjct 390 NLILAVVTMAYEEQN----QATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSH 445
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
++S ++ ++ S GS + +N+ S +
Sbjct 446 NGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFL 490
Score = 99.4 bits (246), Expect = 7e-20, Method: Composition-based stats.
Identities = 38/197 (19%), Positives = 85/197 (43%), Gaps = 10/197 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ + F A++ K F ++ + W + +++ VSL++ V+ LR R
Sbjct 701 NIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVA-KKGSLSVLRSFR 759
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
LLR F L ++ + +K I S+ + ++ ++LAI + +F + G L +++ ++
Sbjct 760 LLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKN 819
Query 249 RE------RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIVFTVIGS 300
+ + S + +L + M + I F+ V+G+
Sbjct 820 ISAPHEDWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGN 878
Query 301 LFLMNLLTAIIYSQFRG 317
L ++NL A++ + F
Sbjct 879 LVVLNLFIALLLNSFSA 895
>sp|Q28644|SCN9A_RABIT Sodium channel protein type 9 subunit alpha
OS=Oryctolagus cuniculus OX=9986 GN=SCN9A PE=2 SV=1
Length=1984
Score = 537 bits (1383), Expect = 5e-169, Method: Composition-based stats.
Identities = 129/701 (18%), Positives = 267/701 (38%), Gaps = 95/701 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
S C R + + F + I S + D+ + + E
Sbjct 1168 ESGKGKIWWNIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKK--KTIKIILEY 1225
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VSLV L +
Sbjct 1226 ADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKS 1285
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1286 LRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK-- 1343
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGSLF 302
++Q + + S +N + + S+N + + F +G
Sbjct 1344 ----------FYQCVNTTDDSRFPTKQVSNRSECFALMNGSQNVRWKNLKVNFDNVG--- 1390
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
+ L+ + + F+G+ M + ++ + + ++E M F +
Sbjct 1391 -LRYLSLLQVATFKGW-MDIMYAAVDSVNVDQQPSYEHNLYMYIY---FVIFIIFGSFFT 1445
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPF 421
L + V +D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1446 LNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKF 1501
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
L + FD ++ N+V++ V +D + +L +N VFI+ +
Sbjct 1502 QGCIFDLVTNQAFDITIMILICLNMVTMMVEKEGQSDYMTD-----VLYWINVVFIILFT 1556
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSL 540
E +LK+ +L Y + N+FD V+++L I + + L + P + ++ L
Sbjct 1557 GECVLKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAELIETYFVSPTLFRVIRL 1611
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ + +R + +M + + G +L +V +++AI G++
Sbjct 1612 ARIGRILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSN 1662
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F V N NF+ F +++ L+ + W L
Sbjct 1663 FAYVKKEAGINDM--------------------FNFETFGNSMICLFQITTSAGWDGLLA 1702
Query 660 --------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILENFLH 699
D + P S YFV + ++S ++ VN+++A+ILENF
Sbjct 1703 PILNSAPPDCDPKKVHPGSSTEGDCGSPSVGIFYFVSYIIISFLVVVNMYIAVILENFSV 1762
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + +PL+ + E D + +L++
Sbjct 1763 ATEEST--EPLSEDDFEMFYEVWEKFDPDATQFIEYSKLSD 1801
Score = 142 bits (357), Expect = 3e-33, Method: Composition-based stats.
Identities = 62/346 (18%), Positives = 116/346 (34%), Gaps = 78/346 (23%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP + + + H F ++ + +++ C+F+ ++ PAE + F
Sbjct 113 SPLRRISIKILVHSLFS----MLIMCTILTNCIFMTMN---NPAEWTKNV----EYTFTG 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+FA G +L P N D ++ V + E L
Sbjct 162 IYTFESLVKIFARGFCVGEFTFLRDPWNWLDFIVIVFAYLTEFVNL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVIILTVFCLSVFA 260
Query 595 IIGINLFRGVIVALP----------------------------------------GNSSL 614
+IG+ LF G + S
Sbjct 261 LIGLQLFMGHLKHKCLRKIENETLESIMSSIESEEDYKKYFYYLEGSKDALLCGFSTDSG 320
Query 615 APANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF 674
G + +Y +FD F+ A + L+ LM + W+ R +G I+F
Sbjct 321 QCPEGYYCVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFF 380
Query 675 VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
V+ + S +NL LA++ ++ +++++ QM
Sbjct 381 VVVIFLGSFYLINLILAVV--AMAYEEQNQANIEEAKQKELEFQQM 424
Score = 117 bits (294), Expect = 1e-25, Method: Composition-based stats.
Identities = 43/264 (16%), Positives = 92/264 (35%), Gaps = 34/264 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SPF + D +L +V +F+ ++ + E + +L + N VF
Sbjct 724 SPFWIKFKKFIYIIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN-VLVVGNLVFTG 782
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ A+ Y NVFD L+ + LV L
Sbjct 783 IFAAEMVLKLIAMDPYEYFQVGWNVFDSLIVTLSLVEL--------------------FL 822
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 823 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGPLGNLTLVLAIIVFIFAVVGM 882
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF L W N DF + + ++ ++ +
Sbjct 883 QLFGKSYKECVC-----------KINDDCSLPRWHMN--DFFHSFLIVFRVLCGEWIETM 929
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D I +++ ++ +
Sbjct 930 WDCMEVAGQAMCLIVYMMVMVIGN 953
Score = 103 bits (257), Expect = 3e-21, Method: Composition-based stats.
Identities = 55/320 (17%), Positives = 110/320 (34%), Gaps = 75/320 (23%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ + L ++F +L + I T + P T++VE ++
Sbjct 116 RRISIKILVHSLFSMLIMCTILTNCIFMTM----------NNPAEWTKNVEYTFTGIYTF 165
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ VK + G+ F ++ W +V+V T ++L LR R+LR
Sbjct 166 ESLVKIFARGFCVGEFTFLRDPWNWLDFIVIV--FAYLTEFVNLGNVSALRTFRVLRALK 223
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G +
Sbjct 224 TISVIPGLKTIVGALIQSVKKLSDVIILTVFCLSVFALIGLQLFMGHLKHKCLRKIENET 283
Query 247 ---------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD------- 276
+ + YF L S +L + NPD
Sbjct 284 LESIMSSIESEEDYKKYFYYLEGSKDALLCGFSTDSGQCPEGYYCVKAGRNPDYGYTSFD 343
Query 277 -----------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+M Y +N + Y IFF+V +GS +L+NL+ A++ +
Sbjct 344 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 403
Query 316 RGYLMKSLQTSLFRRRLGTR 335
+++ + + +
Sbjct 404 EEQNQANIEEAKQKELEFQQ 423
Score = 93.3 bits (230), Expect = 4e-18, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +FAA++ +K + + W + +++ +SLV+ ++ + LR R
Sbjct 777 NLVFTGIFAAEMVLKLIAMDPYEYFQVGWNVFDSLIVTLSLVELFLA-DVEGLSVLRSFR 835
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 836 LLRVFKLAKSWPTLNMLIKIIGNSVGPLGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 895
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + S + +L + M + I +++ VIG+
Sbjct 896 INDDCSLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGN 953
>sp|P35498|SCN1A_HUMAN Sodium channel protein type 1 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN1A PE=1 SV=2
Length=2009
Score = 537 bits (1383), Expect = 7e-169, Method: Composition-based stats.
Identities = 126/697 (18%), Positives = 261/697 (37%), Gaps = 95/697 (14%)
Query 72 WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
C R + F + I S + D+ + + E + +
Sbjct 1201 GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQ--RKTIKTMLEYADKV 1258
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIR 187
+F ++ +K +G+ + N W +++ VSLV T L + LR
Sbjct 1259 FTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTL 1318
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1319 RALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK------ 1372
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNL 306
++ + + + N+ D + ++ + + F +G
Sbjct 1373 ------FYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGF----GY 1422
Query 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
L+ + + F+G+ M + ++ R + + +E M F + L +
Sbjct 1423 LSLLQVATFKGW-MDIMYAAVDSRNVELQPKYEESLYMYLY---FVIFIIFGSFFTLNLF 1478
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSA 425
V +D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1479 IGVIIDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMV 1534
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
FD ++ N+V++ V +E IL +N VFIV + E +
Sbjct 1535 FDFVTRQVFDISIMILICLNMVTMMVET-----DDQSEYVTTILSRINLVFIVLFTGECV 1589
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMT 544
LK+ +L Y + N+FD V+++L I + + L + P + ++ L +
Sbjct 1590 LKLISLR-HYYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIG 1644
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
R+L ++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1645 RILRLIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1695
Query 605 IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----- 659
+ + NF+ F +++ L+ + W L
Sbjct 1696 KREVGIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILN 1735
Query 660 ----DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1736 SKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1795
Query 704 RSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+PL+ + E D + ++L++
Sbjct 1796 --SAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQ 1830
Score = 127 bits (318), Expect = 1e-28, Method: Composition-based stats.
Identities = 42/264 (16%), Positives = 92/264 (35%), Gaps = 34/264 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP+ + + D +L +V +F+ ++ + + +L + N VF
Sbjct 751 SPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAME-HYPMTDHFNNVLTVGNLVFTG 809
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM LK+ A+ Y N+FDG + + LV L
Sbjct 810 IFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVEL--------------------GL 849
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + +L + R ++ S + ++ + V + +L ++ ++FA++G+
Sbjct 850 ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 909
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
LF S QL W N DF + + ++ ++ +
Sbjct 910 QLFGKSYKDCVC-----------KIASDCQLPRWHMN--DFFHSFLIVFRVLCGEWIETM 956
Query 659 LDAYRRYSGPWSKIYFVLWWLVSS 682
D F++ ++ +
Sbjct 957 WDCMEVAGQAMCLTVFMMVMVIGN 980
Score = 115 bits (289), Expect = 5e-25, Method: Composition-based stats.
Identities = 65/371 (18%), Positives = 114/371 (31%), Gaps = 99/371 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ + + + F
Sbjct 115 NPLRKIAIKILVHSLFS----MLIMCTILTNCVFMTMSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V E L
Sbjct 164 IYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRG-----VIVALPGNSSLAPANGSAPC------------------GSFEQLEY 631
+IG+ LF G I P N+SL + S+ Q
Sbjct 263 LIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSR 322
Query 632 WANNFDDFAAALVT--------------------------------------LWNLMVVN 653
+ + F AL+ L+ LM +
Sbjct 323 YHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQD 382
Query 654 NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGT 713
W+ R +G I+FVL + S +NL LA++ ++ ++ L+
Sbjct 383 FWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVV--AMAYEEQNQATLEEAEQK 440
Query 714 PEATYQMTVEL 724
QM +L
Sbjct 441 EAEFQQMIEQL 451
Score = 94.4 bits (233), Expect = 2e-18, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 65/167 (39%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTMS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V ++ T + L LR R+LR +
Sbjct 173 IIARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFVDLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +++ V +L L +F + G+ LF G ++
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277
Score = 92.9 bits (229), Expect = 6e-18, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 76/179 (42%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + ++ +SLV+ ++ ++ LR R
Sbjct 804 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLA-NVEGLSVLRSFR 862
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 863 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 922
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + F++ VIG+
Sbjct 923 IASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 980
Score = 39.7 bits (91), Expect = 0.13, Method: Composition-based stats.
Identities = 17/91 (19%), Positives = 38/91 (42%), Gaps = 1/91 (1%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 361 GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 420
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEV 340
++ + +L+ + + + ++
Sbjct 421 VVAMAYEEQNQATLEEAEQKEAEFQQMIEQL 451
>sp|Q2XVR5|SC4AA_TETNG Sodium channel protein type 4 subunit alpha
A OS=Tetraodon nigroviridis OX=99883 GN=scn4aa PE=3 SV=2
Length=1863
Score = 535 bits (1377), Expect = 7e-169, Method: Composition-based stats.
Identities = 113/689 (16%), Positives = 257/689 (37%), Gaps = 93/689 (13%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
F ++ +++ + C + F + I S + D+
Sbjct 1013 FTDNCVKHWPCLNVDVTQGQGKKWWNLRKTCFTIVEHDWFETFIIFMILLSSGALAFEDI 1072
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
+ E + + +F ++ +K +G+ + N W ++ +SL+
Sbjct 1073 --YIERRRTVKIILEFADKVFTFIFVLEMVLKWVAYGFKTYFTNAWCWLDFFIVDISLIS 1130
Query 172 WTVSL----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ +L L + LR R LRP L M+ + + ++P + +V L+ I
Sbjct 1131 LSANLMGLSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFW 1190
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNR 286
+F++ G+ LFAG ++ + + L + N D M ++
Sbjct 1191 LIFSIMGVNLFAGK------------FYHCINTTTQELFPISVVNNKSDCMAVQEATQEA 1238
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
+ + + +G L+ + + F+G+ + ++ R + + ++E+ M
Sbjct 1239 RWVNVKVNYDNVGK----GYLSLLQIATFKGWTA-IMYAAVDSREVEEQPSYEINLYMYI 1293
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
F + L + V +D+ ++Q K + + EE +K + + +
Sbjct 1294 Y---FVIFIIFGAFFTLNLFIGVIIDNFNQQ----KRKLGDKDIFMTEEQKKYYEAMKKL 1346
Query 407 VVKEH-PPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD 465
K+ P P + +FD ++ N+V+ ++++ D E++
Sbjct 1347 GSKKPQKPIPRPTNLIQGMVFDFISQQFFDIFIMVLICLNMVT----MMVETDDQSPEKE 1402
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
DF+ + N FIV + E +LK+ AL + + + N+FD V+++L I+ + L
Sbjct 1403 DFLFKV-NVAFIVVFTGECMLKLIALR-QYFFTNGWNIFDF----VVVILSIAGTMLSDL 1456
Query 526 PHPGW-RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ P + ++ L + R+L ++ R +R + +M + + G
Sbjct 1457 IEKYFVSPTLFRVIRLARIGRILRLIKGARGIRTLLFALMM---------SLPALFNIGL 1507
Query 585 ILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALV 644
+L ++ ++F+I G++ F V + NF+ F ++++
Sbjct 1508 LLFLIMFIFSIFGMSNFAYVKKEAGIDDM--------------------FNFETFGSSII 1547
Query 645 TLWNLMVVNNWQVFL---------DAYRRYSGPWSKI------------YFVLWWLVSSV 683
L+ + W L D P + + +F + ++S +
Sbjct 1548 CLFQITTSGGWDQILLPILNKEPPDCDPTLENPGTDVKGNCGNPMVGMMFFCSYIIISFL 1607
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ VN+++A+ILENF +
Sbjct 1608 VVVNMYIAIILENFNVAQEESGDALCEED 1636
Score = 234 bits (596), Expect = 3e-63, Method: Composition-based stats.
Identities = 60/339 (18%), Positives = 127/339 (37%), Gaps = 39/339 (12%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
+ ++ + H +F+ + L + ++ D + IL + V
Sbjct 1034 KKWWNLRKTCFTIVEHDWFETFIIFMILLSSGALAFE---DIYIERRRTVKIILEFADKV 1090
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F ++LEM+LK A G + Y + D + + L+ + L
Sbjct 1091 FTFIFVLEMVLKWVAYGFKTYFTNAWCWLDFFIVDISLISLSANLM-------------- 1136
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
LS + L L R LR + + M VV + ++G + ++ + ++ + +F+I
Sbjct 1137 -GLSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFWLIFSI 1195
Query 596 IGINLFRGVIVALPGNSS-----LAPANGSAPCGSFE---QLEYWAN---NFDDFAAALV 644
+G+NLF G ++ ++ N + C + + Q W N N+D+ +
Sbjct 1196 MGVNLFAGKFYHCINTTTQELFPISVVNNKSDCMAVQEATQEARWVNVKVNYDNVGKGYL 1255
Query 645 TLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+L + W + A + IYFV++ + + +NLF+ +I+
Sbjct 1256 SLLQIATFKGWTAIMYAAVDSREVEEQPSYEINLYMYIYFVIFIIFGAFFTLNLFIGVII 1315
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+NF + + Y ++ L ++P
Sbjct 1316 DNFNQQKRKLGDKDIFMTEEQKKYYEAMKKLGSKKPQKP 1354
Score = 129 bits (324), Expect = 3e-29, Method: Composition-based stats.
Identities = 68/485 (14%), Positives = 146/485 (30%), Gaps = 88/485 (18%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + + +L L+T ++ + Y +FF+V +GS +L+NL+ A
Sbjct 355 GYTSFDSFGWAFLALFRLMTQDCWENLFQQTLRAAGKTYMLFFVVVIFLGSFYLINLILA 414
Query 310 IIYSQFRGYLMKSLQTSLFRRR--------LGTRAAFEVLSSMVGEGGAFPQA------- 354
++ + S Q + + L + +VL S +
Sbjct 415 VVAMAYEEQNQASQQEAREKEEEFQWLLEQLKNQEQAQVLGSRASPTSEKSVSLTTSDAP 474
Query 355 ------VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+ +L + +L E
Sbjct 475 DEDQSLENDEALKDCNGRFIPRLIVRAPTMKESAADYESGEKVEGSTHSRLHVEDAGLKQ 534
Query 409 KE------------------HPPRPEYQSPF--------LQSAQFLFGHYYF----DYLG 438
+ P P F +F + D
Sbjct 535 RSASAVTVLTAAAVEELEEAQRPCPPIWYKFANMFLKWNCCQPWAVFKEWVHFVVMDPFV 594
Query 439 NLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLS 498
+L +V +F+ ++ + D++L + N VF + EM K+ A+ Y
Sbjct 595 DLAITICIVLNTLFMAME-HYPMTQEFDYMLSVGNLVFTGIFAAEMFFKLIAMDPYYYFQ 653
Query 499 YPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N+FD ++ + LV L+ +L + R ++
Sbjct 654 VGWNIFDSIIVTLSLVEL--------------------GLANVQGLSVLRSFRLLRVFKL 693
Query 559 IPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
S + ++ + V + +L ++ ++FA++G+ LF S
Sbjct 694 AKSWPTLNMLIKIIGSSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKISTEC-- 751
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK-IYFVLW 677
+L W N DF + + ++ ++ W + A +G + F++
Sbjct 752 ---------ELPRWHMN--DFFHSFLIVFRILCGE-WIENMWACMEVAGAGMCLVVFMMV 799
Query 678 WLVSS 682
++ +
Sbjct 800 MVIGN 804
Score = 127 bits (320), Expect = 8e-29, Method: Composition-based stats.
Identities = 59/361 (16%), Positives = 113/361 (31%), Gaps = 96/361 (27%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ S L + + + ++S CVF+ + ++ + VF Y
Sbjct 106 YILSPFSRVRRGAIKILIHSLIMITILSNCVFMTMSNPPAWSKT-------VEYVFTGIY 158
Query 481 LLEMLLKVFA----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVG 536
E +KV + +G +L P N D ++ + + E L
Sbjct 159 TFEATVKVLSRGFCVGPFTFLRDPWNWLDFMVISMAYITEFVDL---------------- 202
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
L V R L+ I + + + + ++ V+ M + V VFA++
Sbjct 203 -----GNVSALRTFRVLRALKTITVIPGLKTIVAALIQSVKKMVDVMILTVFALSVFALV 257
Query 597 GINLFRGV-------------------IVALPGNSSLAPANGSAPCGSFEQLEYWAN--- 634
G+ LF G + GN + + +F+ EY N
Sbjct 258 GLQLFMGNLRHKCIRWPVAANQSAFEPFNSTVGNDTTGLNDTLFSNITFDFTEYIENAEN 317
Query 635 ----------------------------------------NFDDFAAALVTLWNLMVVNN 654
+FD F A + L+ LM +
Sbjct 318 QYFLPGSADALLCGNSSDAGRCPEGYECMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDC 377
Query 655 WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
W+ R +G ++FV+ + S +NL LA++ ++ ++ Q
Sbjct 378 WENLFQQTLRAAGKTYMLFFVVVIFLGSFYLINLILAVV--AMAYEEQNQASQQEAREKE 435
Query 715 E 715
E
Sbjct 436 E 436
Score = 94.8 bits (234), Expect = 2e-18, Method: Composition-based stats.
Identities = 29/131 (22%), Positives = 56/131 (43%), Gaps = 6/131 (5%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS 175
P +++VE + ++ + +VK G+ G F ++ W +V +S+ T
Sbjct 142 NPPAWSKTVEYVFTGIYTFEATVKVLSRGFCVGPFTFLRDPWNWLDFMV--ISMAYITEF 199
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+ L LR R+LR + +K + + S+ +M V +L L +F + G+
Sbjct 200 VDLGNVSALRTFRVLRALKTITVIPGLKTIVAALIQSVKKMVDVMILTVFALSVFALVGL 259
Query 236 LLFAGGKQDDG 246
LF G +
Sbjct 260 QLFMGNLRHKC 270
Score = 93.6 bits (231), Expect = 3e-18, Method: Composition-based stats.
Identities = 37/179 (21%), Positives = 78/179 (44%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +FAA++ K ++ + W + +++ +SLV+ ++ ++ LR R
Sbjct 628 NLVFTGIFAAEMFFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLA-NVQGLSVLRSFR 686
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 687 LLRVFKLAKSWPTLNMLIKIIGSSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 746
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIVFTVIGS 300
+ + + S + +L + M A + F++ VIG+
Sbjct 747 ISTECELPRWHMNDFFHSFLIVFRILCGE-WIENMWACMEVAGAGMCLVVFMMVMVIGN 804
>sp|P08104|SCN3A_RAT Sodium channel protein type 3 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn3a PE=1 SV=1
Length=1951
Score = 535 bits (1378), Expect = 1e-168, Method: Composition-based stats.
Identities = 132/744 (18%), Positives = 266/744 (36%), Gaps = 102/744 (14%)
Query 15 ARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY 74
+ G A ++ P + + C F E I+
Sbjct 1089 SSEGSTVDVAPPREGEQAEIEPEEDLKPEAC------FTEGCIKKFPFCQVSTEEGKGKI 1142
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
C + F + I S + D+ + + E + +
Sbjct 1143 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RKTIKTMLEYADKVFTY 1200
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV L + LR R L
Sbjct 1201 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1311
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + ++ + N D K + + F +G+ +L L A
Sbjct 1312 ---FYHCVNTTTGNMFEIKEVNNFSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVA- 1365
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
F+G+ M + ++ R + + +E M F + L + V
Sbjct 1366 ---TFKGW-MDIMYAAVDSRDVKLQPIYEENLYMYLY---FVIFIIFGSFFTLNLFIGVI 1418
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSAQFLF 429
+D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1419 IDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFV 1474
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
FD ++ N+V++ V + + +L +N VFIV + E LLK+
Sbjct 1475 TRQVFDISIMILICLNMVTMMVETDDQSKYM-----TLVLSRINLVFIVLFTGEFLLKLI 1529
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRMLN 548
+L Y + N+FD V+++L I + + L + P + ++ L + R+L
Sbjct 1530 SLRY-YYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILR 1584
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL 608
++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1585 LIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1635
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL--------- 659
+ NF+ F +++ L+ + W L
Sbjct 1636 GIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILNSAPP 1675
Query 660 DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1676 DCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE--SA 1733
Query 708 QPLAGTPEATYQMTVELLFRDILE 731
+PL+ + E D +
Sbjct 1734 EPLSEDDFEMFYEVWEKFDPDATQ 1757
Score = 243 bits (621), Expect = 2e-66, Method: Composition-based stats.
Identities = 69/376 (18%), Positives = 137/376 (36%), Gaps = 44/376 (12%)
Query 384 RSYGSVLLSAEEFQKLFNELDRSVVKEHP--------PRPEYQSPFLQSAQFLFGHYYFD 435
R + EE K +K+ P + + ++ + H +F+
Sbjct 1101 REGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFE 1160
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
+ L + ++ D + + +L + VF ++LEMLLK A G +
Sbjct 1161 TFIVFMILLSSGALAFE---DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQT 1217
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y + D L+ V LV ++ Y S + L L R
Sbjct 1218 YFTNAWCWLDFLIVDVSLVSLVANALGY---------------SELGAIKSLRTLRALRP 1262
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-- 613
LR + + M VV + ++G + ++ + ++ + +F+I+G+NLF G ++
Sbjct 1263 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGN 1322
Query 614 ---LAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRY-- 665
+ N + C + + W N NFD+ A + L + W + A
Sbjct 1323 MFEIKEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382
Query 666 --------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
+ +YFV++ + S +NLF+ +I++NF + +
Sbjct 1383 VKLQPIYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442
Query 718 YQMTVELLFRDILEEP 733
Y ++ L ++P
Sbjct 1443 YYNAMKKLGSKKPQKP 1458
Score = 122 bits (305), Expect = 6e-27, Method: Composition-based stats.
Identities = 40/259 (15%), Positives = 93/259 (36%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ L D +L +V +F+ ++ ++ +L + N VF + E
Sbjct 699 KVKHLVNLIVMDPFVDLAITICIVLNTLFMAME-HYPMTQQFSSVLTVGNLVFTGIFTAE 757
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M+LK+ A+ Y N+FDG++ + L+ L+ +
Sbjct 758 MVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL--------------------GLANVEG 797
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 857
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
++ +L W N DF + + ++ ++ + D
Sbjct 858 SYKECVCKINVDC-----------KLPRWHMN--DFFHSFLIVFRVLCGEWIETMWDCME 904
Query 664 RYSGPWSKIYFVLWWLVSS 682
I F+L ++ +
Sbjct 905 VAGQTMCLIVFMLVMVIGN 923
Score = 116 bits (290), Expect = 4e-25, Method: Composition-based stats.
Identities = 63/372 (17%), Positives = 113/372 (30%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ L + + F
Sbjct 115 NPVRKIAIKILVHSLFS----MLIMCTILTNCVFMTLSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V+ V E L
Sbjct 164 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRGVIVALP-----------GNSSLAPANGSAPCGSFEQLEYWANNFDDF---- 639
+IG+ LF G + N++ G+F + N+ D+
Sbjct 263 LIGLQLFMGNLRNKCSQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADD 322
Query 640 ------------------------AAALVT-----------------------LWNLMVV 652
+ L+ LM
Sbjct 323 SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S VNL LA++ ++ ++ L+
Sbjct 383 DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV--AMAYEEQNQATLEEAEQ 440
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 441 KEAEFQQMLEQL 452
Score = 97.1 bits (240), Expect = 3e-19, Method: Composition-based stats.
Identities = 38/206 (18%), Positives = 77/206 (37%), Gaps = 18/206 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTLS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V+V++ V V L LR R+LR +
Sbjct 173 ILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFV--DLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLP 259
+K + + S+ +++ V +L L +F + G+ LF G ++ +
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCS--QWPPSDSAFE 288
Query 260 ESLTSLLVLLTTANNPDVMIPAYSKN 285
+ TS +N V + + N
Sbjct 289 TNTTSYFNGTMDSNGTFVNVTMSTFN 314
Score = 94.4 bits (233), Expect = 2e-18, Method: Composition-based stats.
Identities = 35/180 (19%), Positives = 78/180 (43%), Gaps = 11/180 (6%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + +++ +SL++ ++ ++ LR R
Sbjct 747 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLA-NVEGLSVLRSFR 805
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-- 246
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF G +
Sbjct 806 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVC 864
Query 247 ----QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + I F++ VIG+
Sbjct 865 KINVDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGN 923
Score = 38.6 bits (88), Expect = 0.29, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 422 VVAMAYEEQNQATLEEA-EQKEAEFQ 446
>sp|A2ASI5|SCN3A_MOUSE Sodium channel protein type 3 subunit alpha
OS=Mus musculus OX=10090 GN=Scn3a PE=1 SV=1
Length=1947
Score = 533 bits (1374), Expect = 5e-168, Method: Composition-based stats.
Identities = 133/744 (18%), Positives = 266/744 (36%), Gaps = 102/744 (14%)
Query 15 ARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY 74
+ G A ++ P + + C F E I+
Sbjct 1090 SSEGSTVDVAPPREGEQAEIEPEEDLKPEAC------FTEGCIKKFPFCQVSTEEGKGKI 1143
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
C + F + I S + D+ + + E + +
Sbjct 1144 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RKTIKTMLEYADKVFTY 1201
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV L + LR R L
Sbjct 1202 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1261
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1262 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1312
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + S+ + N D K + + F +G+ +L L A
Sbjct 1313 ---FYHCVNMTTGSMFDMSEVNNFSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVA- 1366
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
F+G+ M + ++ R + + +E M F + L + V
Sbjct 1367 ---TFKGW-MDIMYAAVDSRDVKLQPVYEENLYMYLY---FVIFIIFGSFFTLNLFIGVI 1419
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSAQFLF 429
+D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1420 IDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFV 1475
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
FD ++ N+V++ V + + +L +N VFIV + E LLK+
Sbjct 1476 TRQVFDISIMILICLNMVTMMVETDDQSKYM-----TLVLSRINLVFIVLFTGEFLLKLI 1530
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRMLN 548
+L Y + N+FD V+++L I + + L + P + ++ L + R+L
Sbjct 1531 SLRY-YYFTIGWNIFDF----VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILR 1585
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL 608
++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1586 LIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1636
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL--------- 659
+ NF+ F +++ L+ + W L
Sbjct 1637 GIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILNSAPP 1676
Query 660 DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1677 DCDPDAIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE--SA 1734
Query 708 QPLAGTPEATYQMTVELLFRDILE 731
+PL+ + E D +
Sbjct 1735 EPLSEDDFEMFYEVWEKFDPDATQ 1758
Score = 242 bits (617), Expect = 5e-66, Method: Composition-based stats.
Identities = 69/376 (18%), Positives = 138/376 (37%), Gaps = 44/376 (12%)
Query 384 RSYGSVLLSAEEFQKLFNELDRSVVKEHP--------PRPEYQSPFLQSAQFLFGHYYFD 435
R + EE K +K+ P + + ++ + H +F+
Sbjct 1102 REGEQAEIEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFE 1161
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
+ L + ++ D + + +L + VF ++LEMLLK A G +
Sbjct 1162 TFIVFMILLSSGALAFE---DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQT 1218
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
Y + D L+ V LV ++ Y S + L L R
Sbjct 1219 YFTNAWCWLDFLIVDVSLVSLVANALGY---------------SELGAIKSLRTLRALRP 1263
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-- 613
LR + + M VV + ++G + ++ + ++ + +F+I+G+NLF G ++
Sbjct 1264 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGS 1323
Query 614 ---LAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRY-- 665
++ N + C + + W N NFD+ A + L + W + A
Sbjct 1324 MFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1383
Query 666 --------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
+ +YFV++ + S +NLF+ +I++NF + +
Sbjct 1384 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1443
Query 718 YQMTVELLFRDILEEP 733
Y ++ L ++P
Sbjct 1444 YYNAMKKLGSKKPQKP 1459
Score = 121 bits (304), Expect = 6e-27, Method: Composition-based stats.
Identities = 41/259 (16%), Positives = 91/259 (35%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ L D +L +V +F+ ++ E+ +L + N VF + E
Sbjct 699 KVKHLVNLIVMDPFVDLAITICIVLNTLFMAME-HYPMTEQFSSVLTVGNLVFTGIFTAE 757
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M+LK+ A+ Y N+FDG++ + L+ L+ +
Sbjct 758 MVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL--------------------GLANVEG 797
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 798 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 857
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+L W N DF + + ++ ++ + D
Sbjct 858 SYKECVC-----------KINEDCKLPRWHMN--DFFHSFLIVFRVLCGEWIETMWDCME 904
Query 664 RYSGPWSKIYFVLWWLVSS 682
I F+L ++ +
Sbjct 905 VAGQTMCLIVFMLVMVIGN 923
Score = 118 bits (295), Expect = 8e-26, Method: Composition-based stats.
Identities = 65/372 (17%), Positives = 116/372 (31%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ L + + F
Sbjct 115 NPVRKIAIKILVHSLFS----MLIMCTILTNCVFMTLSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V+ V E L
Sbjct 164 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRGVIVALP-----------GNSSLAPANGSAPCGSFEQLEYWANNFDDFAA-- 641
+IG+ LF G + N++ G+F + N+ D+ A
Sbjct 263 LIGLQLFMGNLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADD 322
Query 642 -------------------------------------------------ALVTLWNLMVV 652
A ++L+ LM
Sbjct 323 SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S VNL LA++ ++ ++ L+
Sbjct 383 DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV--AMAYEEQNQATLEEAEQ 440
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 441 KEAEFQQMLEQL 452
Score = 95.6 bits (236), Expect = 9e-19, Method: Composition-based stats.
Identities = 38/206 (18%), Positives = 77/206 (37%), Gaps = 18/206 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTLS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V+V++ V V L LR R+LR +
Sbjct 173 ILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFV--DLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLP 259
+K + + S+ +++ V +L L +F + G+ LF G ++ +
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC--LQWPPSDSAFE 288
Query 260 ESLTSLLVLLTTANNPDVMIPAYSKN 285
+ TS +N V + + N
Sbjct 289 INTTSYFNGTMDSNGTFVNVTMSTFN 314
Score = 94.4 bits (233), Expect = 2e-18, Method: Composition-based stats.
Identities = 34/179 (19%), Positives = 78/179 (44%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + +++ +SL++ ++ ++ LR R
Sbjct 747 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLA-NVEGLSVLRSFR 805
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 806 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 865
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + S + +L + M + I F++ VIG+
Sbjct 866 INEDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGN 923
Score = 38.6 bits (88), Expect = 0.31, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 422 VVAMAYEEQNQATLEEA-EQKEAEFQ 446
>sp|Q28371|SCN4A_HORSE Sodium channel protein type 4 subunit alpha
OS=Equus caballus OX=9796 GN=SCN4A PE=1 SV=1
Length=1834
Score = 531 bits (1369), Expect = 7e-168, Method: Composition-based stats.
Identities = 125/706 (18%), Positives = 264/706 (37%), Gaps = 105/706 (15%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + + F + I S + D+ + E
Sbjct 1007 SQGRGKMWWTLRRACFKIVEHHWFKTFNSSLILLNSGTLAFEDIYIEQ--RRVIRTILEY 1064
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD----WTVSLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VS++ W L +
Sbjct 1065 ADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKS 1124
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFA
Sbjct 1125 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWVIFSIMGVNLFAAKIY 1184
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
+ + + + N + ++ + + + +G
Sbjct 1185 YF------------INTTTSERFDISGVNNKSECESLIHTGQVRWLNVKVNYDNVG---- 1228
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ M + +++ R + +EV M F + +
Sbjct 1229 LGYLSLLQVATFKGW-MDIMYSAVDSREQEEQPQYEVNIYMYLY---FVIFIIFGSFFTI 1284
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
L ++ + + ++Q K + G + EE +K +N + + K+ P P Q+
Sbjct 1285 NSLIRLIIVNFNQQ----KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ 1340
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
FD ++ N+V+ ++++ D + D IL +N VFI+ +
Sbjct 1341 GMVYDFVTKQVFDITIMILICLNMVT----MMVETDDQSQLKVD-ILYNINMVFIIVFTG 1395
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK+FAL + Y + N+FD V+++L I LA+ L + P + ++ L
Sbjct 1396 ECVLKMFALR-QNYFTVGWNIFDF----VVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1450
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L++V ++++I G++ F
Sbjct 1451 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLILVMFIYSIFGMSNF 1501
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1502 AYVKKESGIDDM--------------------FNFETFGNSIICLFEITTSAGWDGLLNP 1541
Query 660 -------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHK 700
D P + + +F + ++S +I VN+++A+ILENF
Sbjct 1542 ILNSGPPDCDPTLENPGTSVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVA 1601
Query 701 WDPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
+ S P+AT + L F D L+EP
Sbjct 1602 TEESSDPLGEDDFEIFFEKWEKFGPDATQFIDYSRLSDFVDTLQEP 1647
Score = 111 bits (277), Expect = 1e-23, Method: Composition-based stats.
Identities = 58/445 (13%), Positives = 135/445 (30%), Gaps = 57/445 (13%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + +L L+ ++ + Y IFF+V +GS +L+NL+ A
Sbjct 379 GYTSHDTFSWAFLALFRLMIQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILA 438
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + + +L + +++ + +A + +
Sbjct 439 VVTMAYAEQN----EATLAEDQEKEEEFQQMMEKFQKQQEELEKAKADQALEGGEAGGDP 494
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF-- 427
++ G S + + ++ P + + +
Sbjct 495 AHSKDCNGSLDTSPGEKGPPRQSCSADSGVSDAMEELEEAHQKCPPWWYKCAHKVLIWNC 554
Query 428 ---------LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ D +L +V +F+ ++ E D +L + N VF
Sbjct 555 CTPWVKFKNIIHLIVMDPFVDLGITICIVLNTLFMAME-HYPMTEHFDKVLTVGNLVFTG 613
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ EM+LK+ AL Y NVFD ++ + +
Sbjct 614 IFTAEMVLKLIALDPYEYFQQGWNVFDSIIV-----------------------TLSWVE 650
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV---LGLVQNMRAFGGILVVVYYVFAI 595
+ L++L FR +R + K + + + +L ++ F++
Sbjct 651 LGLVNVKGLSVLRSFRLVRSLKLAKSWPTLNMFIRIIGNSGGGLGNLTLVLAIIVVNFSV 710
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
+G+ LF ++ A DF + + + ++ W
Sbjct 711 VGMQLFGKNYKECVCKNASDCALPRWKMC-------------DFFHSFLIVLRILCGE-W 756
Query 656 QVFLDAYRRYSGPWSKIYFVLWWLV 680
+ + +G + +L +V
Sbjct 757 IEPMWGFMEVAGQAMFLTVLLMVMV 781
Score = 94.0 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 30/178 (17%), Positives = 63/178 (35%), Gaps = 16/178 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F + + I + + +D PW T + + +K
Sbjct 126 KVLIHSLFSMFIMITILPNCVVMTMSDP----PPWPIHVENT------FTGINTFESLIK 175
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V++ + T + L LR R+LR +
Sbjct 176 MLARGFCIDDFTFLRDPWNWLDFSVIM--MAYLTEFVDLGNISALRTFRVLRALKTITVI 233
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQN 257
+K + + S+ +++ V +L L +F + G+ LF G + + N
Sbjct 234 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPQPFNDTN 291
Score = 87.5 bits (215), Expect = 3e-16, Method: Composition-based stats.
Identities = 51/327 (16%), Positives = 99/327 (30%), Gaps = 53/327 (16%)
Query 325 TSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR 384
++ RR L A + M + ++ L ++ ++
Sbjct 26 AAIERRALEEEARLQRNKQMEIQETERNARSDLEAGKNLPLIYGDPPPE-----VIGIPL 80
Query 385 SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPF---LQSAQFLFGHYYFDYLGNLI 441
S ++ + N+ P SPF +SA + H F +
Sbjct 81 EDLDPYYSNKKTFIVLNKGKAIFRFSATPALYMLSPFSIIRRSAIKVLIHSLFSMFIMIT 140
Query 442 ALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYL 497
L N V V + D P ++ F E L+K+ A G +L
Sbjct 141 ILPNCV---VMTMSDPPPWPIHVENT--------FTGINTFESLIKMLARGFCIDDFTFL 189
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
P N D + ++ + E L L V R L+
Sbjct 190 RDPWNWLDFSVIMMAYLTEFVDL---------------------GNISALRTFRVLRALK 228
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV---------AL 608
I + + + ++ V+ + + V VFA++G+ LF G +
Sbjct 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPQPFN 288
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANN 635
N++ + ++ + W++N
Sbjct 289 DTNTTWYGNDTWYSNDTWNSNDTWSSN 315
Score = 74.4 bits (181), Expect = 3e-12, Method: Composition-based stats.
Identities = 45/261 (17%), Positives = 91/261 (35%), Gaps = 23/261 (9%)
Query 3 EPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSI 62
E + L GG GG G R D V DA++
Sbjct 477 EKAKADQALEGGEAGGDPAHSKDCNGSLDTSPGEKGPPRQSCSADSGV---SDAMEELEE 533
Query 63 NHRVDASSMWLYRRY--------YSNVCQRT-LSFTIFLILFLAFIETPSSLTSTADVRY 113
H+ Y ++ I LI+ F++ ++ + +
Sbjct 534 AHQ-----KCPPWWYKCAHKVLIWNCCTPWVKFKNIIHLIVMDPFVDLGITICIVLNTLF 588
Query 114 RAAPWEPPCGLTESV----EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSL 169
A P + V ++ +F A++ +K + + W + +++ +S
Sbjct 589 MAMEHYPMTEHFDKVLTVGNLVFTGIFTAEMVLKLIALDPYEYFQQGWNVFDSIIVTLSW 648
Query 170 VDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V+ + ++ LR RL+R L ++ + ++ I S + ++ L+LAI +
Sbjct 649 VELGLV-NVKGLSVLRSFRLVRSLKLAKSWPTLNMFIRIIGNSGGGLGNLTLVLAIIVVN 707
Query 230 FTMFGMLLFAGGKQDDGQDRE 250
F++ GM LF G + +
Sbjct 708 FSVVGMQLF-GKNYKECVCKN 727
Score = 64.7 bits (156), Expect = 3e-09, Method: Composition-based stats.
Identities = 31/141 (22%), Positives = 55/141 (39%), Gaps = 3/141 (2%)
Query 602 RGVIVALPGNSSLA--PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
L GNSS A G + Y + D F+ A + L+ LM+ + W+
Sbjct 347 GAKDALLCGNSSDAGHCPEGYKCIKTGRNPNYGYTSHDTFSWAFLALFRLMIQDYWENLF 406
Query 660 DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQ 719
R +G I+FV+ + S +NL LA++ + + + + + E
Sbjct 407 QLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVTMAYAEQNEA-TLAEDQEKEEEFQQM 465
Query 720 MTVELLFRDILEEPGEDELTE 740
M ++ LE+ D+ E
Sbjct 466 MEKFQKQQEELEKAKADQALE 486
>sp|Q15858|SCN9A_HUMAN Sodium channel protein type 9 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN9A PE=1 SV=3
Length=1988
Score = 533 bits (1372), Expect = 2e-167, Method: Composition-based stats.
Identities = 122/692 (18%), Positives = 259/692 (37%), Gaps = 95/692 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
S C + + + F + I S + D+ + + E
Sbjct 1171 ESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERK--KTIKIILEY 1228
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ VSLV L +
Sbjct 1229 ADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKS 1288
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1289 LRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK-- 1346
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM-IPAYSKNRAYAIFFIVFTVIGSLF 302
+++ + + S N + + S+N + + F +G
Sbjct 1347 ----------FYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVG--- 1393
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
+ L+ + + F+G+ + + ++ + + +E M F
Sbjct 1394 -LGYLSLLQVATFKGWTI-IMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIF---GSFFT 1448
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPF 421
L + V +D+ ++Q K + G + EE +K +N + + K+ P P +
Sbjct 1449 LNLFIGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKI 1504
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
L + FD ++ N+V++ V ++ +L +N VFI+ +
Sbjct 1505 QGCIFDLVTNQAFDISIMVLICLNMVTMMVE-----KEGQSQHMTEVLYWINVVFIILFT 1559
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSL 540
E +LK+ +L Y + N+FD V++++ I + + L + P + ++ L
Sbjct 1560 GECVLKLISLR-HYYFTVGWNIFDF----VVVIISIVGMFLADLIETYFVSPTLFRVIRL 1614
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ + +R + +M + + G +L +V +++AI G++
Sbjct 1615 ARIGRILRLVKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSN 1665
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F V N NF+ F +++ L+ + W L
Sbjct 1666 FAYVKKEDGINDM--------------------FNFETFGNSMICLFQITTSAGWDGLLA 1705
Query 660 --------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLH 699
D + P S + YFV + ++S ++ VN+++A+ILENF
Sbjct 1706 PILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSV 1765
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ + +PL+ + E D +
Sbjct 1766 ATEEST--EPLSEDDFEMFYEVWEKFDPDATQ 1795
Score = 138 bits (348), Expect = 3e-32, Method: Composition-based stats.
Identities = 58/348 (17%), Positives = 112/348 (32%), Gaps = 80/348 (23%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
SP + + + H F ++ + +++ C+F+ ++ + + F
Sbjct 113 SPLRRISIKILVHSLFS----MLIMCTILTNCIFMTMNNPPDWTKN-------VEYTFTG 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D ++ V + E L
Sbjct 162 IYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
+IG+ LF G +
Sbjct 261 LIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTD 320
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
S G +Y +FD F+ A + L+ LM + W+ R +G I
Sbjct 321 SGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMI 380
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
+FV+ + S +NL LA++ ++ +++++ QM
Sbjct 381 FFVVVIFLGSFYLINLILAVV--AMAYEEQNQANIEEAKQKELEFQQM 426
Score = 121 bits (304), Expect = 7e-27, Method: Composition-based stats.
Identities = 42/267 (16%), Positives = 94/267 (35%), Gaps = 38/267 (14%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
Y F + F+ + D + + N +F+ ++ + E + +L I N V
Sbjct 728 PYWIKFKKCIYFIVMDPFVDLAITICIVLNT----LFMAMEHHPMTEEFKN-VLAIGNLV 782
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F + EM+LK+ A+ Y N+FD L+ + LV
Sbjct 783 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVEL------------------- 823
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
L+ + +L + R ++ S + ++ + V + +L ++ ++FA+
Sbjct 824 -FLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 882
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
+G+ LF + L W N DF + + ++ ++
Sbjct 883 VGMQLFGKSYKECVCKINDDCT-----------LPRWHMN--DFFHSFLIVFRVLCGEWI 929
Query 656 QVFLDAYRRYSGPWSKIYFVLWWLVSS 682
+ D I +++ ++ +
Sbjct 930 ETMWDCMEVAGQAMCLIVYMMVMVIGN 956
Score = 103 bits (256), Expect = 4e-21, Method: Composition-based stats.
Identities = 56/322 (17%), Positives = 109/322 (34%), Gaps = 77/322 (24%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ + L ++F +L + I T + P T++VE ++
Sbjct 116 RRISIKILVHSLFSMLIMCTILTNCIFMTM----------NNPPDWTKNVEYTFTGIYTF 165
Query 139 DLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ VK G+ F ++ W VV+V T ++L LR R+LR
Sbjct 166 ESLVKILARGFCVGEFTFLRDPWNWLDFVVIV--FAYLTEFVNLGNVSALRTFRVLRALK 223
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-------- 246
+ +K + + S+ +++ V +L L +F + G+ LF G +
Sbjct 224 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENN 283
Query 247 -----------QDRERLTYFQNLPESLTSL--------------LVLLTTANNPD----- 276
+ + YF L S +L + NPD
Sbjct 284 ETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTS 343
Query 277 -------------VMIPAYSKN----------RAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
+M Y +N + Y IFF+V +GS +L+NL+ A++
Sbjct 344 FDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAM 403
Query 314 QFRGYLMKSLQTSLFRRRLGTR 335
+ +++ + + +
Sbjct 404 AYEEQNQANIEEAKQKELEFQQ 425
Score = 93.3 bits (230), Expect = 5e-18, Method: Composition-based stats.
Identities = 36/193 (19%), Positives = 78/193 (40%), Gaps = 9/193 (5%)
Query 115 AAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV 174
E + ++ +FAA++ +K + + W + +++ +SLV+ +
Sbjct 766 HPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFL 825
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
+ + LR RLLR F L ++ + +K I S+ + ++ L+LAI + +F + G
Sbjct 826 A-DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 884
Query 235 MLLFAGGKQDD-----GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRA 287
M LF ++ + + S + +L + M +
Sbjct 885 MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAM 943
Query 288 YAIFFIVFTVIGS 300
I +++ VIG+
Sbjct 944 CLIVYMMVMVIGN 956
>sp|Q9NY46|SCN3A_HUMAN Sodium channel protein type 3 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN3A PE=1 SV=2
Length=2000
Score = 531 bits (1368), Expect = 7e-167, Method: Composition-based stats.
Identities = 129/744 (17%), Positives = 263/744 (35%), Gaps = 102/744 (14%)
Query 15 ARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY 74
+ G + P + + C F E I+
Sbjct 1138 SSEGSTVDVVLPREGEQAETEPEEDLKPEAC------FTEGCIKKFPFCQVSTEEGKGKI 1191
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
C + F + I S + D+ + + E + +
Sbjct 1192 WWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ--RKTIKTMLEYADKVFTY 1249
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
+F ++ +K +G+ + N W +++ VSLV L + LR R L
Sbjct 1250 IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK--------- 1360
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++ + + ++ + N D K + + F +G+ +L L A
Sbjct 1361 ---FYHCVNMTTGNMFDISDVNNLSDCQALG--KQARWKNVKVNFDNVGAGYLALLQVA- 1414
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
F+G+ M + ++ R + + +E M F + L + V
Sbjct 1415 ---TFKGW-MDIMYAAVDSRDVKLQPVYEENLYMYLY---FVIFIIFGSFFTLNLFIGVI 1467
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFLQSAQFLF 429
+D+ ++Q K + G + EE +K +N + + K+ P P + F
Sbjct 1468 IDNFNQQ----KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFV 1523
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
FD ++ N+V++ V + +L +N VFIV + E +LK+
Sbjct 1524 TRQVFDISIMILICLNMVTMMVET-----DDQGKYMTLVLSRINLVFIVLFTGEFVLKLV 1578
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLWDMTRMLN 548
+L Y + N+FD V+++L I + + + + P + ++ L + R+L
Sbjct 1579 SLR-HYYFTIGWNIFDF----VVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILR 1633
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL 608
++ + +R + +M + + G +L +V +++AI G++ F V
Sbjct 1634 LIKGAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEA 1684
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL--------- 659
+ NF+ F +++ L+ + W L
Sbjct 1685 GIDDM--------------------FNFETFGNSMICLFQITTSAGWDGLLAPILNSAPP 1724
Query 660 DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
D P S + +FV + ++S ++ VN+++A+ILENF +
Sbjct 1725 DCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE--SA 1782
Query 708 QPLAGTPEATYQMTVELLFRDILE 731
+PL+ + E D +
Sbjct 1783 EPLSEDDFEMFYEVWEKFDPDATQ 1806
Score = 242 bits (618), Expect = 4e-66, Method: Composition-based stats.
Identities = 63/338 (19%), Positives = 129/338 (38%), Gaps = 36/338 (11%)
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
+ + ++ + H +F+ + L + ++ D + + +L +
Sbjct 1188 KGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFE---DIYIEQRKTIKTMLEYAD 1244
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
VF ++LEMLLK A G + Y + D L+ V LV ++ Y
Sbjct 1245 KVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGY---------- 1294
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
S + L L R LR + + M VV + ++G + ++ + ++ + +F
Sbjct 1295 -----SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIF 1349
Query 594 AIIGINLFRGVIVALPGNSS-----LAPANGSAPCGSFEQLEYWAN---NFDDFAAALVT 645
+I+G+NLF G ++ ++ N + C + + W N NFD+ A +
Sbjct 1350 SIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLA 1409
Query 646 LWNLMVVNNWQVFLDAYRRY----------SGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
L + W + A + +YFV++ + S +NLF+ +I++
Sbjct 1410 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIID 1469
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
NF + + Y ++ L ++P
Sbjct 1470 NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1507
Score = 141 bits (355), Expect = 5e-33, Method: Composition-based stats.
Identities = 54/318 (17%), Positives = 123/318 (39%), Gaps = 44/318 (14%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ V ++ +I +++ L + ++ D + + + + ++ +++F
Sbjct 1520 FDFVTRQVFDISIMILICLNMV----TMMVETDDQGKYM-----TLVLSRINLVFIVLFT 1570
Query 138 ADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV-------SLSLVCHEPLRIRRLL 190
+ +K ++ W + VV+++S+V + +S +R+ R+
Sbjct 1571 GEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIG 1629
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L++ + ++ L + SLP + ++GLLL + + ++ +FGM FA K++ G D
Sbjct 1630 RILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGID-- 1687
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS---------------------KNRAYA 289
+ F+ S+ L + T+A ++ P + N +
Sbjct 1688 DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVG 1747
Query 290 I-FFIVFTVIGSLFLMNLLTAIIYSQFR---GYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
I FF+ + +I L ++N+ A+I F + L F F+ ++
Sbjct 1748 IFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQF 1807
Query 346 GEGGAFPQAVGVKPQNLL 363
E LL
Sbjct 1808 IEFSKLSDFAAALDPPLL 1825
Score = 123 bits (308), Expect = 2e-27, Method: Composition-based stats.
Identities = 42/259 (16%), Positives = 91/259 (35%), Gaps = 34/259 (13%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ L D +L +V +F+ ++ E+ +L + N VF + E
Sbjct 748 KVKHLVNLIVMDPFVDLAITICIVLNTLFMAME-HYPMTEQFSSVLTVGNLVFTGIFTAE 806
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M+LK+ A+ Y N+FDG++ + L+ LS +
Sbjct 807 MVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL--------------------GLSNVEG 846
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+L + R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 847 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 906
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+ L W N DF + + ++ ++ + D
Sbjct 907 SYKECVCKINDDCT-----------LPRWHMN--DFFHSFLIVFRVLCGEWIETMWDCME 953
Query 664 RYSGPWSKIYFVLWWLVSS 682
I F+L ++ +
Sbjct 954 VAGQTMCLIVFMLVMVIGN 972
Score = 121 bits (303), Expect = 9e-27, Method: Composition-based stats.
Identities = 64/372 (17%), Positives = 117/372 (31%), Gaps = 100/372 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A + H F ++ + +++ CVF+ L + + F
Sbjct 115 NPVRKIAIKILVHSLFS----MLIMCTILTNCVFMTLSNPPDWTKN-------VEYTFTG 163
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G +L P N D + V+ V E +L
Sbjct 164 IYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSL-------------- 209
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 210 -------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 262
Query 595 IIGINLFRGVIVALP-----------GNSSLAPANGSAPCGSFEQLEYWANNFDDF---- 639
+IG+ LF G + N++ G+F + N+ D+
Sbjct 263 LIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDD 322
Query 640 -----------------------------------------------AAALVTLWNLMVV 652
+ A ++L+ LM
Sbjct 323 SHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 382
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ W+ R +G I+FVL + S VNL LA++ ++ ++ L+
Sbjct 383 DYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVV--AMAYEEQNQATLEEAEQ 440
Query 713 TPEATYQMTVEL 724
QM +L
Sbjct 441 KEAEFQQMLEQL 452
Score = 97.9 bits (242), Expect = 2e-19, Method: Composition-based stats.
Identities = 39/206 (19%), Positives = 78/206 (38%), Gaps = 18/206 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F +L + I T + + W T++VE ++ + +K
Sbjct 123 KILVHSLFSMLIMCTILTNCVFMTLS----NPPDW------TKNVEYTFTGIYTFESLIK 172
Query 144 GYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ F ++ W V+V++ V V SL LR R+LR +
Sbjct 173 ILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFV--SLGNVSALRTFRVLRALKTISVI 230
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLP 259
+K + + S+ +++ V +L L +F + G+ LF G ++ +
Sbjct 231 PGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC--LQWPPSDSAFE 288
Query 260 ESLTSLLVLLTTANNPDVMIPAYSKN 285
+ TS +N V + + N
Sbjct 289 TNTTSYFNGTMDSNGTFVNVTMSTFN 314
Score = 95.9 bits (237), Expect = 7e-19, Method: Composition-based stats.
Identities = 35/179 (20%), Positives = 77/179 (43%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F A++ +K ++ + W + +++ +SL++ +S ++ LR R
Sbjct 796 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLS-NVEGLSVLRSFR 854
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF ++
Sbjct 855 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 914
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + S + +L + M + I F++ VIG+
Sbjct 915 INDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGN 972
Score = 38.6 bits (88), Expect = 0.27, Method: Composition-based stats.
Identities = 17/86 (20%), Positives = 37/86 (43%), Gaps = 2/86 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + SL L+T ++ + Y IFF++ +GS +L+NL+ A
Sbjct 362 GYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILA 421
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + +L+ + ++ +
Sbjct 422 VVAMAYEEQNQATLEEA-EQKEAEFQ 446
>sp|Q62968|SCNAA_RAT Sodium channel protein type 10 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn10a PE=1 SV=1
Length=1956
Score = 530 bits (1364), Expect = 2e-166, Method: Composition-based stats.
Identities = 122/689 (18%), Positives = 261/689 (38%), Gaps = 87/689 (13%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ S W C R + + F + I S + D P + E
Sbjct 1132 SKSPWATGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVK--SVLEY 1189
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEP 183
+ + +F ++ +K +G+ + N W +++ +SL + +
Sbjct 1190 TDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKA 1249
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1250 LRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFS 1309
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
R F N+ ++ N + +++N F++ V
Sbjct 1310 KCVDTRN--NPFSNVNSTM--------VNNKSEC----HNQNSTGHFFWVNVKVNFDNVA 1355
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
M L + + F+G+ M + ++ + ++ +E M F G L
Sbjct 1356 MGYLALLQVATFKGW-MDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGG---FFTL 1411
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P + +
Sbjct 1412 NLFVGVIIDNFNQQ----KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ 1467
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+ FD + ++ N+++ ++++ D E+ +LG +N F+ +
Sbjct 1468 GFVFDIVTRQAFDIIIMVLICLNMIT----MMVETDEQGEEKTK-VLGRINQFFVAVFTG 1522
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
E ++K+FAL + Y + NVFD + V+L + + A+ + + P + ++ L
Sbjct 1523 ECVMKMFALR-QYYFTNGWNVFDF-IVVILSIGSLLFSAILKSLENYFSPTLFRVIRLAR 1580
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
+ R+L ++ + +R + +M + + G +L +V ++++I G+ F
Sbjct 1581 IGRILRLIRAAKGIRTLLFALMM---------SLPALFNIGLLLFLVMFIYSIFGMASFA 1631
Query 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
V+ + NF F +++ L+ + W L
Sbjct 1632 NVVDEAGIDDM--------------------FNFKTFGNSMLCLFQITTSAGWDGLLSPI 1671
Query 663 RRYSGPWSK--------------------IYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
P+ I+F + ++S +I VN+++A+ILENF +
Sbjct 1672 LNTGPPYCDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATE 1731
Query 703 PRSHLQPLAGTPEATYQMTVELLFRDILE 731
+ +PL+ + T E + +
Sbjct 1732 EST--EPLSEDDFDMFYETWEKFDPEATQ 1758
Score = 232 bits (592), Expect = 1e-62, Method: Composition-based stats.
Identities = 60/342 (18%), Positives = 124/342 (36%), Gaps = 40/342 (12%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
++ + H +F+ + L + ++ D + R +L + VF +
Sbjct 1142 VRKTCYRIVEHSWFESFIIFMILLSSGALAFE---DNYLEEKPRVKSVLEYTDRVFTFIF 1198
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+ EMLLK A G + Y + D L+ + L I+ + Y S
Sbjct 1199 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILEY---------------SD 1243
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ L L R LR + + M VV ++G + ++ + ++ + +F+I+G+NL
Sbjct 1244 VASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1303
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN------------NFDDFAAALVTLWN 648
F G + +N ++ + + + N NFD+ A + L
Sbjct 1304 FAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLALLQ 1363
Query 649 LMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ W + A + +YFV++ + +NLF+ +I++NF
Sbjct 1364 VATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFN 1423
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+ + Y ++ L ++P L +
Sbjct 1424 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1465
Score = 147 bits (372), Expect = 4e-35, Method: Composition-based stats.
Identities = 65/349 (19%), Positives = 121/349 (35%), Gaps = 77/349 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A + H +F + L N V + + + VF V
Sbjct 117 NLIRRTAIKVSVHSWFSIFITITILVNCVCM--------------TRTDLPEKVEYVFTV 162
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E L+K+ A G YL P N D + + V L
Sbjct 163 IYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL-------------- 208
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ + + + V+ ++ V+ + + V VFA
Sbjct 209 -------RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFA 261
Query 595 IIGINLFRG--------------------------VIVALPGNSSLAPANGSA------- 621
++G+ LF+G + + L NGS
Sbjct 262 LVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHCPGG 321
Query 622 --PCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWL 679
+ + ++ +FD FA A ++L+ LM ++W+ R SG ++FVL
Sbjct 322 YVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIF 381
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
+ S VNL LA++ ++ ++ + + E +Q +E+L ++
Sbjct 382 LGSFYLVNLILAVV--TMAYEEQSQATIAEIEAK-EKKFQEALEVLQKE 427
Score = 122 bits (305), Expect = 5e-27, Method: Composition-based stats.
Identities = 50/281 (18%), Positives = 98/281 (35%), Gaps = 35/281 (12%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + + D L +V VF+ ++ + D +L N VF V+
Sbjct 648 PKWRKFKMALFELVTDPFAELTITLCIVVNTVFMAME-HYPMTDAFDAMLQAGNIVFTVF 706
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
+ +EM K+ A Y N+FD ++ V L+ G LS
Sbjct 707 FTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLL--------------ELSASKKGSLS 752
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L + R ++ S + + + V + IL ++ ++FA++G
Sbjct 753 V------LRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQ 806
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
L S E + DF + + ++ ++ W +
Sbjct 807 LLS------------EDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGE-WIENM 853
Query 660 DAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
S I F+ ++ +++ +NLF+AL+L +F
Sbjct 854 WVCMEVSQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSA 894
Score = 112 bits (281), Expect = 4e-24, Method: Composition-based stats.
Identities = 50/343 (15%), Positives = 112/343 (33%), Gaps = 63/343 (18%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLV 179
L E VE + +++ + +K G+ + ++ W V ++L ++ L
Sbjct 152 LPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSV--ITLAYVGAAIDLR 209
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR R+LR + +K + + S+ ++A V +L L +F + G+ LF
Sbjct 210 GISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFK 269
Query 240 GGKQDDG----------------------------------------------------- 246
G ++
Sbjct 270 GNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHCPGGYVCLKTPD 329
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS-KNRAYAIFFIVFTVIGSLFLMN 305
T F + + SL L+T + + + Y +FF++ +GS +L+N
Sbjct 330 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVN 389
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L+ A++ + ++ + + + A EVL + +
Sbjct 390 LILAVVTMAYEEQSQATI-AEIEAKEKKFQEALEVL--QKEQEVLAALGIDTTSLQSHSG 446
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+++ ++ ++ S GS + +N+ S +
Sbjct 447 SPLASKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFL 489
Score = 97.9 bits (242), Expect = 2e-19, Method: Composition-based stats.
Identities = 39/203 (19%), Positives = 85/203 (42%), Gaps = 10/203 (5%)
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
+ ++ ++ + F +++ K F ++ + W + V++ VSL++ + S
Sbjct 694 AMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSAS-KKGSLS 752
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR RLLR F L ++ + +K I S+ + ++ +LAI + +F + G L +
Sbjct 753 VLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDY 812
Query 243 QDDG------QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIV 294
+ + + S + +L + M S+ I F+
Sbjct 813 GCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEVSQKSICLILFLT 871
Query 295 FTVIGSLFLMNLLTAIIYSQFRG 317
V+G+L ++NL A++ + F
Sbjct 872 VMVLGNLVVLNLFIALLLNSFSA 894
>sp|Q20JQ7|SC4AB_DANRE Sodium channel protein type 4 subunit alpha
B OS=Danio rerio OX=7955 GN=scn4ab PE=2 SV=1
Length=1784
Score = 524 bits (1350), Expect = 2e-165, Method: Composition-based stats.
Identities = 123/672 (18%), Positives = 259/672 (39%), Gaps = 91/672 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ + C + + F + I S + D+ + E
Sbjct 951 SQGKGKAWWNFRKTCFAIVEHSYFETFIIFMILLSSGALAFEDIYIEQ--RRMIKIILEY 1008
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEP 183
+ + VF ++ +K +G+ + N W +++ VSL+ T ++ L +
Sbjct 1009 ADQVFTYVFVVEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGYSELGAIKS 1068
Query 184 LRIRRLLRPFFLLQNSSMMKKTL-KCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1069 LRTLRALRPLRALSRFEGMRVVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKF 1128
Query 243 QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLF 302
+ + N+ + T L+ +P+V + I F +G
Sbjct 1129 YYCFNETSEEVFDHNVVNNKTDCYELMEF--HPEV---------RWMNGKINFDNVG--- 1174
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
M L + + F+G+ M + +++ R + ++ +E M F +
Sbjct 1175 -MGYLALLQVATFKGW-MDIMYSAVDSRAIESQPVYEANLYMYIY---FVIFIIFGSFFT 1229
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPF 421
L + V +D+ ++Q K + G+ + EE +K +N + + K+ P P +
Sbjct 1230 LNLFIGVIIDNFNQQ----KAKLGGTDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPTNCC 1285
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
+FD ++ N+V+ ++++ D AE ++ IL +N FI+ +
Sbjct 1286 QGLVFDFVTQQFFDIFIMVMICLNMVT----MMVETDDQSAEIEE-ILFYINFAFIILFT 1340
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSL 540
E +LK+ AL Y S N+FD V+++L I + + L + P + ++ L
Sbjct 1341 GECVLKITALRY-HYFSIGWNIFDF----VVVILSILGIGLADLIEKYFVSPTLFRVIRL 1395
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ + +R + +M + + G +L ++ ++F+I G++
Sbjct 1396 ARIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSN 1446
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F V + + NF+ F +++ ++ + W L
Sbjct 1447 FAYVKKEVGIDDM--------------------MNFETFGNSIICMFMITTSAGWDGLLA 1486
Query 660 -------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILENFLHK 700
D P S ++F + ++S ++ VN+++A+ILENF
Sbjct 1487 PILNSPPDCDPDVDNPGSTTRGNCGNAAVGIVFFCSYIVMSFLVVVNMYIAIILENFNVA 1546
Query 701 WDPRSHLQPLAG 712
+ S
Sbjct 1547 TEESSDPLCEDD 1558
Score = 295 bits (755), Expect = 6e-84, Method: Composition-based stats.
Identities = 119/699 (17%), Positives = 244/699 (35%), Gaps = 119/699 (17%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +FAA++ +K ++ + W + +++ +SLV+ ++ + LR R
Sbjct 604 NLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLVELMLA-DVEGLSVLRSFR 662
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD---- 244
L+R F L ++ + +K I S+ + ++ L+LAI + +F + GM LF D
Sbjct 663 LMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYTDSVCK 722
Query 245 -DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGSL 301
+ + + + +L + M + I F++ VIG+L
Sbjct 723 ISSDCELPRWHMADFFHAFLIIFRVLCGE-WIETMWDCMEVAGQGMCIIVFMMVMVIGNL 781
Query 302 FLM-------------------------NLLTAII-YSQFRGYLMKSLQTSLFRRRLGTR 335
++ NL AI ++ ++ + + R+ L +
Sbjct 782 VVLNLFLALLLSSFSGDNLSASDDDGENNLQIAISRITRGIDWIKAFVNKHV-RQCLNLK 840
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQV-LQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
E + + GEG A A+ ++++V + + D E G +
Sbjct 841 PKEE-GAKVNGEGDAKMNAIMNSSSSMVKVPIANGESDDDDGNGSSEDEDDEGRDINMK- 898
Query 395 EFQKLFNELDRSVVKEHPP--------------------------------------RPE 416
+K +E + PP + +
Sbjct 899 --KKNGDESSTCSTVDKPPEVEDLVEEEEEDLTSPEDCYTENCIRRCPCLDLDVSQGKGK 956
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
F ++ + H YF+ + L + ++ D + IL + VF
Sbjct 957 AWWNFRKTCFAIVEHSYFETFIIFMILLSSGALAFE---DIYIEQRRMIKIILEYADQVF 1013
Query 477 IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVG 536
+++EMLLK A G + Y + D L+ V L+ + + Y
Sbjct 1014 TYVFVVEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSLISLTANILGY------------- 1060
Query 537 LLSLWDMTRMLNMLIVFRFLRIIPSMKLMA-VVASTVLGLVQNMRAFGGILVVVYYVFAI 595
S + L L R LR + + M VV + ++G + ++ + ++ + +F+I
Sbjct 1061 --SELGAIKSLRTLRALRPLRALSRFEGMRVVVVNALVGAIPSIFNVLLVCLIFWLIFSI 1118
Query 596 IGINLFRGVIVALPGNSSLAPANGS--------APCGSFEQLEYWAN---NFDDFAAALV 644
+G+NLF G +S + + F W N NFD+ +
Sbjct 1119 MGVNLFAGKFYYCFNETSEEVFDHNVVNNKTDCYELMEFHPEVRWMNGKINFDNVGMGYL 1178
Query 645 TLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALIL 694
L + W + + + IYFV++ + S +NLF+ +I+
Sbjct 1179 ALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYMYIYFVIFIIFGSFFTLNLFIGVII 1238
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+NF + + Y ++ L ++P
Sbjct 1239 DNFNQQKAKLGGTDIFMTEEQKKYYNAMKKLGSKKPQKP 1277
Score = 131 bits (328), Expect = 8e-30, Method: Composition-based stats.
Identities = 68/455 (15%), Positives = 152/455 (33%), Gaps = 57/455 (13%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T + N + +L L+T ++ + Y IFF+V +GS +L+NL+ A
Sbjct 360 GYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILA 419
Query 310 IIYSQFRGYLMKSLQTSLFR-----------RRLGTRAAFEVLSSMVGEGGAFPQAVGVK 358
++ + + + + ++ + V S
Sbjct 420 VVAMAYAEQNEATAAEAKEKEEEYAKIMEQLKKQAEQKNGMVNGSKTSLSSKKKGDNDQM 479
Query 359 PQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ 418
+ + K S+ + + + S + + + LD E P P +
Sbjct 480 QSDYDGIALKPLSKSNGSKGNINYLEVPDSQIRKPSVVSAVESALDAQEDIERPCPPGWY 539
Query 419 SPFLQSAQF-----------LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDF 467
++ + + D +L +V VF+ ++ + +
Sbjct 540 KFADIFLKWDCCIPWVKFKRIVYLFVMDPFVDLGITLCIVLNTVFMAME-HYPMSVHVEE 598
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
+L I N VF + EM+LK+ AL Y N+FD ++ + LV
Sbjct 599 VLAIGNLVFTGIFAAEMVLKLIALDPYYYFQVGWNIFDSIIVTMSLVEL----------- 647
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+L+ + +L + R ++ S + ++ + V + +L
Sbjct 648 ---------MLADVEGLSVLRSFRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 698
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
++ ++FA++G+ LF + + S +L W DF A + ++
Sbjct 699 IIVFIFAVVGMQLFGK-----------SYTDSVCKISSDCELPRWHM--ADFFHAFLIIF 745
Query 648 NLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS 682
++ + D I F++ ++ +
Sbjct 746 RVLCGEWIETMWDCMEVAGQGMCIIVFMMVMVIGN 780
Score = 127 bits (320), Expect = 9e-29, Method: Composition-based stats.
Identities = 61/344 (18%), Positives = 110/344 (32%), Gaps = 94/344 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P ++A + H F + L L N CVF+ + ++ IL VF
Sbjct 117 NPVRRAAIRILIHSLFSLVIMLTILTN----CVFMAMSDPPGWSK-------ILEYVFTG 165
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E ++KV + G +L P N D ++ + + E L
Sbjct 166 IYTFEAMVKVLSRGFCIGDFTFLRDPWNWLDFMVISMAYLTEFVDL-------------- 211
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + + ++ V+ + + V VFA
Sbjct 212 -------GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFA 264
Query 595 IIGINLFRGVIVALP-----------------------GNSSLAPANGSAPCGSFEQLEY 631
+IG+ LF G + GN + + E+ Y
Sbjct 265 LIGLQLFMGNLRQKCVLWPPVGWYSDNLTVLSNYTDINGNGTANSTFDYQKYINSEENYY 324
Query 632 WA-----------------------------------NNFDDFAAALVTLWNLMVVNNWQ 656
+ ++D+F A + L+ LM + W+
Sbjct 325 YVPGQMDPLVCGNSSDAGLCPEGYICLKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWE 384
Query 657 VFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHK 700
R +G I+FV+ + S +NL LA++ + +
Sbjct 385 NLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQ 428
Score = 99.0 bits (245), Expect = 7e-20, Method: Composition-based stats.
Identities = 34/172 (20%), Positives = 65/172 (38%), Gaps = 16/172 (9%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
R L ++F ++ + I T + +D W E + ++
Sbjct 120 RRAAIRILIHSLFSLVIMLTILTNCVFMAMSDP----PGWSKIL------EYVFTGIYTF 169
Query 139 DLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ VK G+ G F ++ W +V +S+ T + L LR R+LR
Sbjct 170 EAMVKVLSRGFCIGDFTFLRDPWNWLDFMV--ISMAYLTEFVDLGNISALRTFRVLRALK 227
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+ +K + + S+ ++A V +L L +F + G+ LF G +
Sbjct 228 TITVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKC 279
>sp|Q2XVR4|SC4AB_TETNG Sodium channel protein type 4 subunit alpha
B OS=Tetraodon nigroviridis OX=99883 GN=scn4ab PE=3 SV=1
Length=1715
Score = 520 bits (1339), Expect = 2e-164, Method: Composition-based stats.
Identities = 135/705 (19%), Positives = 275/705 (39%), Gaps = 102/705 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + F + I S + D+ + + E
Sbjct 893 SQGKGKVWCNIRRACFIIVENNYFESFIVFMILLSSGALAFEDIYLEKH--QLIKTILEY 950
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEP 183
+ + VF ++ +K + +G+ + N W +++ VSLV T ++ L +
Sbjct 951 ADKVFTYVFVVEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGYSELGAIKS 1010
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1011 LRTLRALRPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCLIFWLIFSIMGVNLFAGKFS 1070
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
+ + + + + + T + L+ AN +V + + + +G
Sbjct 1071 YCFNETSQEQFDKKIVNNKTECIALIE-ANFTEV---------RWKNLKVNYDNVG---- 1116
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ M+ + ++ R + ++ +EV M F + L
Sbjct 1117 IGYLSLLQVATFKGW-MEIMYAAVDSRDVESQPIYEVNIYMYLY---FVIFIIFGSFFTL 1172
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P ++
Sbjct 1173 NLFIGVIIDNFNQQ----KAKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPENALQ 1228
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
L FD ++ N+V+ ++++ D E++D IL +N +FIV +
Sbjct 1229 GLVFDLVTKQIFDVFIMVLICLNMVT----MMVETDEQTKEKED-ILYWINVIFIVIFTT 1283
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E +LK AL R Y S NVFD V+++L I L + + + P + ++ L
Sbjct 1284 ECILKTIALR-RHYFSIGWNVFDF----VVVILSILGLLLADIIEKYFVSPTLFRVIRLA 1338
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L ++ ++F+I G++ F
Sbjct 1339 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSNF 1389
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1390 AYVKKEAMIDDM--------------------FNFETFGNSMICLFMITTSAGWDGLLSP 1429
Query 660 ------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILENFLHKW 701
D P + ++F + ++S ++ VN+++A+ILENF
Sbjct 1430 IMNKPPDCDPDLENPGTTVRGNCGSPAIGIVFFSTYIIMSFLVVVNMYIAIILENFNVAT 1489
Query 702 DPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
+ S P+AT + L F D L+EP
Sbjct 1490 EESSDPLCEDDFDMFYETWEKFDPDATQFIQYSKLSDFCDTLKEP 1534
Score = 280 bits (717), Expect = 5e-79, Method: Composition-based stats.
Identities = 118/689 (17%), Positives = 231/689 (34%), Gaps = 104/689 (15%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +F ++ +K + + W + +++ +SLV+ ++ ++ LR R
Sbjct 551 NLVFTGIFTCEMVLKILAMDPYFYFQVGWNIFDSIIVTMSLVELGLA-NVQGLSVLRSFR 609
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
L+R F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 610 LMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYKDCVCR 669
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGSL 301
+ + + + + +L D M S I +++ VIG+L
Sbjct 670 ISEDCKLPRWHMNDFFHAFLIIFRVLCGE-WIDTMWDCMEVSGQTMCLIVYMMVLVIGNL 728
Query 302 FLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV---------------- 345
++NL A++ S F G +L + A + V
Sbjct 729 VVLNLFLALLLSSFSG---DNLAAQDDEGENNLQIAVNRIKRAVAWAKTWILLHLCILTE 785
Query 346 -----------GEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
E + + KV + + + S
Sbjct 786 SNHNQHDAVSDEEENRITKNILALTSVTSDQFFKVPIAEAESDSEDSDDDDVDEDKHSRC 845
Query 395 EFQKLFNELDRSVVKE---------HPPRPEYQSPFLQSA--------------QFLFGH 431
+ + + VKE P +
Sbjct 846 DESSFCSTVQDPEVKENEADEDNVSKMPMDCWSENCYSRCPSLDIDTSQGKGKVWCNIRR 905
Query 432 YYF-----DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
F +Y + I L+S D + + IL + VF +++EM+L
Sbjct 906 ACFIIVENNYFESFIVFMILLSSGALAFEDIYLEKHQLIKTILEYADKVFTYVFVVEMVL 965
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K FA G + Y S D L+ V LV + + Y S +
Sbjct 966 KWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGY---------------SELGAIKS 1010
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L L R LR + + M VV + ++G V ++ + ++ + +F+I+G+NLF G
Sbjct 1011 LRTLRALRPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCLIFWLIFSIMGVNLFAGKFS 1070
Query 607 ALPGNSSLAP-----ANGSAPCGSFEQLE----YWAN---NFDDFAAALVTLWNLMVVNN 654
+S N C + + W N N+D+ ++L +
Sbjct 1071 YCFNETSQEQFDKKIVNNKTECIALIEANFTEVRWKNLKVNYDNVGIGYLSLLQVATFKG 1130
Query 655 WQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPR 704
W + A + +YFV++ + S +NLF+ +I++NF +
Sbjct 1131 WMEIMYAAVDSRDVESQPIYEVNIYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKAKL 1190
Query 705 SHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ Y ++ L ++P
Sbjct 1191 GGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1219
Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats.
Identities = 99/658 (15%), Positives = 213/658 (32%), Gaps = 100/658 (15%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ L ++F + +A I T + +D W +++VE + ++
Sbjct 116 RIFAIKILVHSLFSLFIMATILTNCVFMTLSDP----PAW------SKTVEYVFTFIYTF 165
Query 139 DLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+ ++K G+ G F K+ W +V +S+ T + L LR R+LR
Sbjct 166 EATIKVVSRGFCVGQFTFLKDPWNWLDFMV--ISMAYLTELVDLGNVSVLRTFRVLRALK 223
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ +K + + S+ ++A +L L +F + G+ LF G + +
Sbjct 224 TITVIPGLKTIVGALIQSVKKLADAMVLTVFCLSVFALIGLQLFMGNLRQKCVLIPPVVS 283
Query 255 --FQNLPESLTSLLVLLTTAN---NPDVMIPAYSKNRAYAIFFIVF-----TVIGSLFLM 304
+ S T N N D+M ++ + + G+
Sbjct 284 NLTFEVTNSSHGYFGNDTRGNDTENKDLMFEFEEHINNPDNYYYLAGQRDPLLCGNSSDA 343
Query 305 NL----LTAIIYSQFRGYLMKSLQ----TSLFRRRLGTRAAFEVLSSM------VGEGGA 350
+ + + Y S L RL T+ +E L +
Sbjct 344 GVCPESYICLKVGRNPNYGYTSYDSFGWAFLALFRLMTQDFWENLFQLTLRAAGKTYMIF 403
Query 351 FPQAVGVKPQNLLQVLQKVQLDSSHKQA---MMEKVRSYGSVLLSAEEFQKLFNEL---D 404
F + + L+ ++ V + +Q M E + L E +K E
Sbjct 404 FVVVIFLGSFYLINLILAVVAMAYAEQNQATMAEAKQKEEEYLHILEALKKREEEQAAWK 463
Query 405 RSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY--------------------LGNLIALA 444
++ + P E + F + + + +L
Sbjct 464 EALKVQEPHNFEDDHKLCPPCWYAFANVFLKWDCCSCWRHLKRCLSAIVMDPFVDLGITI 523
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
++ +F+ ++ + + +L + N VF + EM+LK+ A+ Y N+F
Sbjct 524 CIILNTIFMAME-HYPMSADFEELLSVGNLVFTGIFTCEMVLKILAMDPYFYFQVGWNIF 582
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL 564
D ++ + LV L+ +L + R ++ S
Sbjct 583 DSIIVTMSLVEL--------------------GLANVQGLSVLRSFRLMRVFKLAKSWPT 622
Query 565 MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
+ ++ + V + +L ++ ++FA++G+ LF S
Sbjct 623 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYKDCVCRISEDC-------- 674
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS 682
+L W N DF A + ++ ++ D I +++ ++ +
Sbjct 675 ---KLPRWHMN--DFFHAFLIIFRVLCGEWIDTMWDCMEVSGQTMCLIVYMMVLVIGN 727
Score = 116 bits (291), Expect = 3e-25, Method: Composition-based stats.
Identities = 69/398 (17%), Positives = 119/398 (30%), Gaps = 107/398 (27%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ A + H F L N CVF+ L ++ + VF
Sbjct 113 NSMRIFAIKILVHSLFSLFIMATILTN----CVFMTLSDPPAWSKT-------VEYVFTF 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E +KV + G +L P N D ++ + + E+ L
Sbjct 162 IYTFEATIKVVSRGFCVGQFTFLKDPWNWLDFMVISMAYLTELVDL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSVLRTFRVLRALKTITVIPGLKTIVGALIQSVKKLADAMVLTVFCLSVFA 260
Query 595 IIGINLFRG-------VIVALPGNSSLAPANGSAPCGSFE-------------QLEYWAN 634
+IG+ LF G +I + N + N S + + E N
Sbjct 261 LIGLQLFMGNLRQKCVLIPPVVSNLTFEVTNSSHGYFGNDTRGNDTENKDLMFEFEEHIN 320
Query 635 NFDD--------------------------------------------FAAALVTLWNLM 650
N D+ F A + L+ LM
Sbjct 321 NPDNYYYLAGQRDPLLCGNSSDAGVCPESYICLKVGRNPNYGYTSYDSFGWAFLALFRLM 380
Query 651 VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPL 710
+ W+ R +G I+FV+ + S +NL LA++ + + Q
Sbjct 381 TQDFWENLFQLTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYAEQN------QAT 434
Query 711 AGTPEATYQMTVELLFRDILEEPGEDELTERLS-QHPH 747
+ + + +L E + E L Q PH
Sbjct 435 MAEAKQKEEEYLHILEALKKREEEQAAWKEALKVQEPH 472
>sp|Q2XVR7|SC4AA_TAKRU Sodium channel protein type 4 subunit alpha
A OS=Takifugu rubripes OX=31033 GN=scn4aa PE=3 SV=1
Length=1892
Score = 523 bits (1346), Expect = 3e-164, Method: Composition-based stats.
Identities = 110/673 (16%), Positives = 252/673 (37%), Gaps = 93/673 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + F + I S + D+ + E
Sbjct 1049 SQGKGKKWWNLRKTCFTIVEHDWFETFIIFMILLSSGALAFEDI--YIERRRTVKIVLEF 1106
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEP 183
+ + +F ++ +K +G+ + N W ++ +SL+ + +L L +
Sbjct 1107 ADKVFTFIFVIEMLLKWVAYGFKTYFTNAWCWLDFFIVDISLISLSANLMGFSDLGPIKS 1166
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1167 LRTLRALRPLRALSRFEGMRVVVNALIGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGK-- 1224
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLF 302
+++ + + L + N D + ++ + + + +
Sbjct 1225 ----------FYRCINTTTAELFPISVVNNKSDCVALQEATQEARWVNVKVNYDNVAK-- 1272
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
L+ + + F+G+ M + ++ R + + ++E+ M F +
Sbjct 1273 --GYLSLLQIATFKGW-MDIMYPAVDSREVEEQPSYEINLYMYIY---FVIFIIFGSFFT 1326
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPF 421
L + V +D+ ++Q K + + EE +K + + + K+ P P +
Sbjct 1327 LNLFIGVIIDNFNQQ----KKKLGDKDIFMTEEQKKYYEAMKKLGSKKPQKPIPRPANLI 1382
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
+FD ++ N+V+ ++++ D ++DF+ + N FIV +
Sbjct 1383 QGLVFDFISQQFFDIFIMVLICLNMVT----MMVETDDQSPAKEDFLFKV-NVAFIVVFT 1437
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSL 540
E LK+FAL + + N+FD ++++L I+ + + + P + ++ L
Sbjct 1438 GECTLKLFALR-HYFFTNGWNIFDF----IVVILSIAGTMLSDIIEKYFVSPTLFRVIRL 1492
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ R +R + +M + + G +L ++ ++F+I G++
Sbjct 1493 ARIGRILRLIKGARGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSN 1543
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F V N NF+ F ++++ L+ + W L
Sbjct 1544 FAYVKKEAGINDM--------------------FNFETFGSSIICLFQITTSAGWDTLLL 1583
Query 660 --------DAYRRYSGPWSK------------IYFVLWWLVSSVIWVNLFLALILENFLH 699
D + P + ++F + ++S ++ VN+++A+ILENF
Sbjct 1584 PMLNKEPPDCDPAFENPGTDVKGNCGNPMMGMVFFCSYIIISFLVVVNMYIAIILENFNV 1643
Query 700 KWDPRSHLQPLAG 712
+ +
Sbjct 1644 AQEESGDVLCEED 1656
Score = 120 bits (301), Expect = 2e-26, Method: Composition-based stats.
Identities = 40/267 (15%), Positives = 90/267 (34%), Gaps = 38/267 (14%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
E F + F+ + D + + N + + + E D++L + N V
Sbjct 596 EKWVVFKKWVHFVVMDPFVDLAITICIVLNTLFMAME-----HYPMTEEFDYMLSVGNLV 650
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F + EM K+ A+ Y N+FD ++ + LV
Sbjct 651 FTGIFAAEMFFKLIAMDPYYYFQVGWNIFDSIIVTLSLVEL------------------- 691
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
L+ +L + R ++ S + ++ + V + +L ++ ++FA+
Sbjct 692 -GLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 750
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNW 655
+G+ LF S +L W N DF + + ++ ++
Sbjct 751 VGMQLFGKSYKDCVC-----------KISSDCELPRWHMN--DFFHSFLIVFRILCGEWI 797
Query 656 QVFLDAYRRYSGPWSKIYFVLWWLVSS 682
+ D + F++ ++ +
Sbjct 798 ETMWDCMEVAGAGMCLVVFMMVMVIGN 824
Score = 99.4 bits (246), Expect = 6e-20, Method: Composition-based stats.
Identities = 57/344 (17%), Positives = 109/344 (32%), Gaps = 79/344 (23%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
S + A + H F L + L+N CVF+ + ++ + VF
Sbjct 112 SLVRRGAIKILIHSLFSTLIMITILSN----CVFMTMSNPPAWSKT-------VEYVFTG 160
Query 479 YYLLEMLLKVFA----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E +KV + +G +L P N D ++ + + E L
Sbjct 161 IYTFEATVKVLSRGFCVGPFTFLRDPWNWLDFMVISMAYITEFVDLG---------NVSA 211
Query 535 VGLLSLWDMTRMLNMLIVFRFL--RIIPSMKLMAVVASTVLGLVQNMRAFGGILV----- 587
+ + + + ++ + + +I S+K M V + + G L
Sbjct 212 LRTFRVLRALKTITVIPGLKTIVAALIQSVKKMVDVMILTVFALAVFALVGLQLFMGNLR 271
Query 588 ---VVYYVFAIIGINLFRGVIV--ALPGNSSLAPANGSAPCGSFEQLEYWAN-------- 634
+ + + LF G + L N + + +F+ EY N
Sbjct 272 HKCIRWPIANETASELFNGTVFNDTLSYNDTTWLNDTLDSNSTFDFTEYIENAENQYFLE 331
Query 635 -----------------------------------NFDDFAAALVTLWNLMVVNNWQVFL 659
+FD F A + L+ LM +NW+
Sbjct 332 GSKDALLCGNSTDAGKCPEGYLCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDNWESLF 391
Query 660 DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
R +G ++FV+ + S +NL LA++ + +
Sbjct 392 QLTLRAAGQTYMLFFVVVIFLGSFYLINLILAVVAMAYDEQNQA 435
Score = 95.2 bits (235), Expect = 1e-18, Method: Composition-based stats.
Identities = 33/167 (20%), Positives = 67/167 (40%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F L + I + + + W +++VE + ++ + +VK
Sbjct 120 KILIHSLFSTLIMITILSNCVFMTMS----NPPAW------SKTVEYVFTGIYTFEATVK 169
Query 144 ----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ G F ++ W +V +S+ T + L LR R+LR +
Sbjct 170 VLSRGFCVGPFTFLRDPWNWLDFMV--ISMAYITEFVDLGNVSALRTFRVLRALKTITVI 227
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ +M V +L L +F + G+ LF G +
Sbjct 228 PGLKTIVAALIQSVKKMVDVMILTVFALAVFALVGLQLFMGNLRHKC 274
Score = 94.8 bits (234), Expect = 2e-18, Method: Composition-based stats.
Identities = 37/179 (21%), Positives = 77/179 (43%), Gaps = 9/179 (5%)
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRR 188
++ +FAA++ K ++ + W + +++ +SLV+ ++ ++ LR R
Sbjct 648 NLVFTGIFAAEMFFKLIAMDPYYYFQVGWNIFDSIIVTLSLVELGLA-NVQGLSVLRSFR 706
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD--- 245
LLR F L ++ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 707 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCK 766
Query 246 --GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA--IFFIVFTVIGS 300
+ + S + +L + M A + F++ VIG+
Sbjct 767 ISSDCELPRWHMNDFFHSFLIVFRILCGE-WIETMWDCMEVAGAGMCLVVFMMVMVIGN 824
Score = 40.5 bits (93), Expect = 0.068, Method: Composition-based stats.
Identities = 16/62 (26%), Positives = 30/62 (48%), Gaps = 1/62 (2%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLTA 309
T F + + +L L+T N + + Y +FF+V +GS +L+NL+ A
Sbjct 364 GYTSFDSFGWAFLALFRLMTQDNWESLFQLTLRAAGQTYMLFFVVVIFLGSFYLINLILA 423
Query 310 II 311
++
Sbjct 424 VV 425
>sp|Q2XVR6|SC4AB_TAKRU Sodium channel protein type 4 subunit alpha
B OS=Takifugu rubripes OX=31033 GN=scn4ab PE=3 SV=1
Length=1719
Score = 516 bits (1329), Expect = 8e-163, Method: Composition-based stats.
Identities = 132/705 (19%), Positives = 274/705 (39%), Gaps = 102/705 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
+ C + F + I S + D+ + + E
Sbjct 897 SQGRGKIWCNIRRTCFSIVENNYFESFIVFMILLSSGALAFEDIYLEKH--QLIKSILEY 954
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEP 183
+ + VF ++ +K + +G+ + N W +++ VSLV T ++ L +
Sbjct 955 ADKVFTYVFVMEMVLKWFAYGFKSYFSNAWCWLDFLIVDVSLVSLTANILGYSELGAIKS 1014
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR R LRP L M+ + + ++P + +V L+ I +F++ G+ LFAG
Sbjct 1015 LRTLRALRPLRALSRFEGMRVVVNALVGAVPSIFNVLLVCLIFWLIFSIMGVNLFAGKFS 1074
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
+ + + ++ T + L+ AN +V + + + +G
Sbjct 1075 YCFNETSQEIIDTKVVDNKTECIALIK-ANFTEV---------RWKNVKVNYDNVG---- 1120
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L+ + + F+G+ + ++ R + ++ +EV M F + L
Sbjct 1121 IGYLSLLQVATFKGW-TDIMYAAVDSRDVESQPIYEVNLYMYLY---FVIFIIFGSFFTL 1176
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH-PPRPEYQSPFL 422
+ V +D+ ++Q K + G + EE +K +N + + K+ P P ++PF
Sbjct 1177 NLFIGVIIDNFNQQ----KAKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPVPRPENPFQ 1232
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
L FD ++ N+V+ ++++ D ++++ +L +N VFI+ +
Sbjct 1233 GLVFDLVTKQIFDVFIMVLICLNMVT----MMVETDEQSDKKEE-VLYWINVVFILIFTT 1287
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSLW 541
E LK+ AL R Y S N+FD V+++L I L + + + P + ++ L
Sbjct 1288 ECTLKIIALR-RHYFSIGWNIFDF----VVVILSILGLLLADIIEKYFVSPTLFRVIRLA 1342
Query 542 DMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
+ R+L ++ + +R + +M + + G +L ++ ++F+I G++ F
Sbjct 1343 RIGRVLRLIRGAKGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSNF 1393
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-- 659
V + NF+ F +++ L+ + W L
Sbjct 1394 AYVKKEALIDDM--------------------FNFETFGNSMICLFMITTSAGWDGLLSP 1433
Query 660 ------DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKW 701
D P + + +F + ++S ++ VN+F+A+ILENF
Sbjct 1434 IMNTPPDCDPNVENPGTTVRGNCGSPAIGIAFFSTYIIMSFLVVVNMFIAIILENFNVAT 1493
Query 702 DPRSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
+ S P+A+ + L F D L+EP
Sbjct 1494 EESSDPLCEDDFEMFYETWEKFDPDASQFIQYSKLSDFCDTLKEP 1538
Score = 119 bits (297), Expect = 5e-26, Method: Composition-based stats.
Identities = 58/433 (13%), Positives = 134/433 (31%), Gaps = 70/433 (16%)
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTA 309
T + + + +L L+T ++ + + Y IFF+V +GS +L+NL+ A
Sbjct 362 GYTSYDSFGWAFLALFRLMTQDFWENLFQLTLRTAGKTYMIFFVVVIFLGSFYLINLILA 421
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ A+ + + + L+ ++
Sbjct 422 VVA-----------------------MAYAEQNEATLAEAKEKEEEYIHILEALKKREEE 458
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
Q + +E + + +K + +
Sbjct 459 QAARKEPHSTVEGFEDDHRLCPP------CWYAFANIFLK--WDCCGCWRHLKECLYAIV 510
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
+ D + + N V + + + + +L + N VF + EM+ K+
Sbjct 511 MDPFVDLGITICIILNTVFMAME-----HYPMSADFEELLSVGNLVFTGIFTGEMVFKIL 565
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A+ Y N+FD ++ + LV L+ +L
Sbjct 566 AMDPYFYFQVGWNIFDSIIVTISLVEL--------------------GLANVQGLSVLRS 605
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ R ++ S + ++ + V + +L ++ ++FA++G+ LF
Sbjct 606 FRLMRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYKDCV 665
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
S L W N DF A + ++ ++ + D
Sbjct 666 CRISEDCV-----------LPRWHMN--DFFHAFLIIFRVLCGEWIESMWDCMEVSGQTM 712
Query 670 SKIYFVLWWLVSS 682
I F++ ++ +
Sbjct 713 CLIVFMMVLVIGN 725
Score = 110 bits (275), Expect = 2e-23, Method: Composition-based stats.
Identities = 58/353 (16%), Positives = 106/353 (30%), Gaps = 100/353 (28%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ A + H F L N C F+ L ++ + VF
Sbjct 113 NALRIVAIKILIHSLFSLFIMATILTN----CAFMTLSDPPAWSKTME-------YVFTF 161
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E +K+ + G +L P N D ++ + + E+ L
Sbjct 162 IYTFEATIKILSRGFCVGKFTFLKDPWNWLDFMVISMAYLTELVDL-------------- 207
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+L V R L+ I + + + ++ V+ + + V VFA
Sbjct 208 -------GNVSVLRTFRVLRALKTITVIPGLKTIVGALIQSVRKLADAMVLTVFCLSVFA 260
Query 595 IIGINLFRGVIVALP--------GNSSLAPANGSAPCGSFE------------QLEYWAN 634
+IG+ LF G + GN + + + G+ + E N
Sbjct 261 LIGLQLFMGNLRQKCVLIPQWLYGNLTFDINSTNGYYGNDTHDNGTKSKHLEFEFERHIN 320
Query 635 NFDD--------------------------------------------FAAALVTLWNLM 650
N D+ F A + L+ LM
Sbjct 321 NPDNYYYLTGQGDPLLCGNSSDAGVCPESYVCLKVGANPNYGYTSYDSFGWAFLALFRLM 380
Query 651 VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
+ W+ R +G I+FV+ + S +NL LA++ + + +
Sbjct 381 TQDFWENLFQLTLRTAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYAEQNEA 433
Score = 94.0 bits (232), Expect = 2e-18, Method: Composition-based stats.
Identities = 33/167 (20%), Positives = 70/167 (42%), Gaps = 16/167 (10%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ L ++F + +A I T + + +D W ++++E + ++ + ++K
Sbjct 121 KILIHSLFSLFIMATILTNCAFMTLSDP----PAW------SKTMEYVFTFIYTFEATIK 170
Query 144 ----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNS 199
G+ G F K+ W +V +S+ T + L LR R+LR +
Sbjct 171 ILSRGFCVGKFTFLKDPWNWLDFMV--ISMAYLTELVDLGNVSVLRTFRVLRALKTITVI 228
Query 200 SMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
+K + + S+ ++A +L L +F + G+ LF G +
Sbjct 229 PGLKTIVGALIQSVRKLADAMVLTVFCLSVFALIGLQLFMGNLRQKC 275
Score = 92.9 bits (229), Expect = 6e-18, Method: Composition-based stats.
Identities = 42/230 (18%), Positives = 92/230 (40%), Gaps = 13/230 (6%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV----EVLCLLVFA 137
C R L ++ I+ F++ ++ + + A P E + ++ +F
Sbjct 498 CWRHLKECLYAIVMDPFVDLGITICIILNTVFMAMEHYPMSADFEELLSVGNLVFTGIFT 557
Query 138 ADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQ 197
++ K + + W + +++ +SLV+ ++ ++ LR RL+R F L +
Sbjct 558 GEMVFKILAMDPYFYFQVGWNIFDSIIVTISLVELGLA-NVQGLSVLRSFRLMRVFKLAK 616
Query 198 NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD-----GQDRERL 252
+ + +K I S+ + ++ L+LAI + +F + GM LF +D
Sbjct 617 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYKDCVCRISEDCVLPR 676
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPA--YSKNRAYAIFFIVFTVIGS 300
+ + + + +L + M S I F++ VIG+
Sbjct 677 WHMNDFFHAFLIIFRVLCGE-WIESMWDCMEVSGQTMCLIVFMMVLVIGN 725
>sp|P02719|SCNA_ELEEL Sodium channel protein OS=Electrophorus
electricus OX=8005 PE=1 SV=1
Length=1820
Score = 508 bits (1307), Expect = 4e-159, Method: Composition-based stats.
Identities = 118/670 (18%), Positives = 251/670 (37%), Gaps = 90/670 (13%)
Query 69 SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
C + F + I S + + D+ + E
Sbjct 980 QGKGKIWWNLRRTCYTIVEHDYFETFIIFMILLSSGVLAFEDIYIW--RRRVIKVILEYA 1037
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPL 184
+ + VF ++ +K +G+ + + W V++ S++ T SL L + L
Sbjct 1038 DKVFTYVFIVEMLLKWVAYGFKRYFTDAWCWLDFVIVGASIMGITSSLLGYEELGAIKNL 1097
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R R LRP L MK ++ + ++P + +V L+ + +F++ G+ LFAG
Sbjct 1098 RTIRALRPLRALSRFEGMKVVVRALLGAIPSIMNVLLVCLMFWLIFSIMGVNLFAGK--- 1154
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLM 304
+++ + + +L + N D M Y+ + + + G M
Sbjct 1155 ---------FYRCINTTTDEILPVEEVNNRSDCMALMYTNEVRWVNLKVNYDNAG----M 1201
Query 305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
L+ + S F+G+ M + ++ R + + +E+ M F + L
Sbjct 1202 GYLSLLQVSTFKGW-MDIMYAAVDSREVEDQPIYEINVYMYLY---FVIFIVFGAFFTLN 1257
Query 365 VLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQS 424
+ V +D+ ++Q K + G L EE +K +N + + K+ S +Q
Sbjct 1258 LFIGVIIDNFNRQ----KQKLGGEDLFMTEEQKKYYNAMKKLGSKKAAKCIPRPSNVVQG 1313
Query 425 AQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + + D + N+V++ V ++ IL +N +F++ + +E
Sbjct 1314 VVYDIVTQPFTDIFIMALICINMVAMMVE-----SEDQSQVKKDILSQINVIFVIIFTVE 1368
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
LLK+ AL + + + NVFD + V+ ++ L + P + ++ L +
Sbjct 1369 CLLKLLALR-QYFFTVGWNVFDFAVVVISIIG---LLLSDIIEKYFVSPTLFRVIRLARI 1424
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
R+L ++ + +R + +M + + G +L ++ ++F+I G++ F
Sbjct 1425 ARVLRLIRAAKGIRTLLFALMM---------SLPALFNIGLLLFLIMFIFSIFGMSNFAY 1475
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---- 659
V + NF+ F +++ L+ + W L
Sbjct 1476 VKKQGGVDD--------------------IFNFETFGNSMICLFEITTSAGWDGLLLPTL 1515
Query 660 -----DAYRRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFLHKWD 702
D P + + +F + ++S ++ VN+++A+ILENF +
Sbjct 1516 NTGPPDCDPDVENPGTDVRGNCGNPGKGITFFCSYIILSFLVVVNMYIAIILENFGVAQE 1575
Query 703 PRSHLQPLAG 712
S L
Sbjct 1576 ESSDLLCEDD 1585
Score = 218 bits (556), Expect = 4e-58, Method: Composition-based stats.
Identities = 59/332 (18%), Positives = 121/332 (36%), Gaps = 38/332 (11%)
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
+ + ++ + H YF+ + L S V D + IL +
Sbjct 982 KGKIWWNLRRTCYTIVEHDYFETFIIFMILL---SSGVLAFEDIYIWRRRVIKVILEYAD 1038
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
VF +++EMLLK A G + Y + D ++ ++ S+L Y
Sbjct 1039 KVFTYVFIVEMLLKWVAYGFKRYFTDAWCWLDFVIVGASIMGITSSLLGYEELG------ 1092
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
+ L + R LR + + M VV +LG + ++ + ++ + +F
Sbjct 1093 ---------AIKNLRTIRALRPLRALSRFEGMKVVVRALLGAIPSIMNVLLVCLMFWLIF 1143
Query 594 AIIGINLFRGVIVALPGNSS-----LAPANGSAPCGS--FEQLEYWAN---NFDDFAAAL 643
+I+G+NLF G ++ + N + C + + W N N+D+
Sbjct 1144 SIMGVNLFAGKFYRCINTTTDEILPVEEVNNRSDCMALMYTNEVRWVNLKVNYDNAGMGY 1203
Query 644 VTLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALI 693
++L + W + A + +YFV++ + + +NLF+ +I
Sbjct 1204 LSLLQVSTFKGWMDIMYAAVDSREVEDQPIYEINVYMYLYFVIFIVFGAFFTLNLFIGVI 1263
Query 694 LENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
++NF + + Y ++ L
Sbjct 1264 IDNFNRQKQKLGGEDLFMTEEQKKYYNAMKKL 1295
Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats.
Identities = 103/707 (15%), Positives = 212/707 (30%), Gaps = 154/707 (22%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK----GY 145
+F+ F + ++ + P ++ VE ++ ++ VK G+
Sbjct 118 VFVNSAFNFFIMFTIFSNCIFMTISNPP-----AWSKIVEYTFTGIYTFEVIVKVLSRGF 172
Query 146 LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
G F ++ W V+ ++ + + L LR R+LR + +K
Sbjct 173 CIGHFTFLRDPWNWLDFSVVTMTYITE--FIDLRNVSALRTFRVLRALKTITIFPGLKTI 230
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG---KQDDGQDRERLTYFQNLPESL 262
++ + S+ +M V +L L +FT+ GM LF G K +++ +
Sbjct 231 VRALIESMKQMGDVVILTVFSLAVFTLAGMQLFMGNLRHKCIRWPISNVTLDYESAYNTT 290
Query 263 TSLLVLLTTA----------------NNPD---------VMIPAYSKNRAYAIF------ 291
+ NN D M + N Y +
Sbjct 291 FDFTAYIENEENQYFLDGALDALLCGNNSDAGKCPEGYTCMKAGRNPNYGYTNYDNFAWT 350
Query 292 -------------------------------FIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
FI+ +GS +L+NL+ A++ +
Sbjct 351 FLCLFRLMLQDYWENLYQMTLRAAGKSYMVFFIMVIFLGSFYLINLILAVVAMAYEEQNQ 410
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ------KVQLDSS 374
+L + + + A E L + +A Q + + +
Sbjct 411 ATLAEAQE-KEAEFQRAVEQLRIQQEQINDERKASLASQLTQNQEAEITDDGDDAIKECN 469
Query 375 HKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP---------------EYQS 419
K + +R SV LS EE + +D + P E
Sbjct 470 GKAFPLANIREPSSVKLSTEEQRSDSKSMDSKHSVDKPSLKHKAASTMSVFTLEDLEAAR 529
Query 420 PFLQSAQFLFGHYYFDY--------------------LGNLIALANLVSICVFLVLDADV 459
+ F + F + +L ++ +F+ ++
Sbjct 530 RPCPPVWYKFAGFVFKWNCCGPWVFLKKWVHFVMMDPFTDLFITLCIILNTLFMSIE-HH 588
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
E +L N VF + EM+LK+ AL Y N+FD ++
Sbjct 589 PMNESFQSLLSAGNLVFTTIFAAEMVLKIIALDPYYYFQQTWNIFDSIIV---------- 638
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
+ LS +L L + R ++ S + ++ + V +
Sbjct 639 ----------SLSLLELGLSNMQGMSVLRSLRLLRIFKLAKSWPTLNILIKIICNSVGAL 688
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
+L ++ ++FA++G LF +L W N DF
Sbjct 689 GNLTIVLAIIVFIFALVGFQLFGK-----------NYKEYVCKISDDCELPRWHMN--DF 735
Query 640 AAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIW 685
+ + ++ + W + G P +++ ++ +++
Sbjct 736 FHSFLIVFRALCGE-WIETMWDCMEVGGVPMCLAVYMMVIIIGNLVM 781
Score = 135 bits (339), Expect = 5e-31, Method: Composition-based stats.
Identities = 55/377 (15%), Positives = 121/377 (32%), Gaps = 83/377 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A +F + F++ +N C+F+ + ++ I+ F
Sbjct 109 NPIRRGAIRVFVNSAFNFFIMFTIFSN----CIFMTISNPPAWSK-------IVEYTFTG 157
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E+++KV + G +L P N D + + + E L
Sbjct 158 IYTFEVIVKVLSRGFCIGHFTFLRDPWNWLDFSVVTMTYITEFIDL-------------- 203
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L V R L+ I + + ++ ++ M + V VF
Sbjct 204 -------RNVSALRTFRVLRALKTITIFPGLKTIVRALIESMKQMGDVVILTVFSLAVFT 256
Query 595 IIGINLFRGVIVALP--------------------------------------------- 609
+ G+ LF G +
Sbjct 257 LAGMQLFMGNLRHKCIRWPISNVTLDYESAYNTTFDFTAYIENEENQYFLDGALDALLCG 316
Query 610 -GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP 668
+ + G + Y N+D+FA + L+ LM+ + W+ R +G
Sbjct 317 NNSDAGKCPEGYTCMKAGRNPNYGYTNYDNFAWTFLCLFRLMLQDYWENLYQMTLRAAGK 376
Query 669 WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
++F++ + S +NL LA++ + + + + + E + + ++
Sbjct 377 SYMVFFIMVIFLGSFYLINLILAVVAMAY-EEQNQATLAEAQEKEAEFQRAVEQLRIQQE 435
Query 729 ILEEPGEDELTERLSQH 745
+ + + L +L+Q+
Sbjct 436 QINDERKASLASQLTQN 452
>sp|Q9R053|SCNBA_MOUSE Sodium channel protein type 11 subunit
alpha OS=Mus musculus OX=10090 GN=Scn11a PE=1 SV=2
Length=1765
Score = 495 bits (1274), Expect = 1e-154, Method: Composition-based stats.
Identities = 138/699 (20%), Positives = 269/699 (38%), Gaps = 105/699 (15%)
Query 66 VDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+ S W+ C + + + F + I S DV L
Sbjct 1012 IKKKSPWVLWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDV--NLPSRPQVEKLL 1069
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLR 185
+ + + +F ++ +K FG+ + + W +++VVS + T +L + R
Sbjct 1070 KCTDNIFTFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSLT---NLPNLKSFR 1126
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--GKQ 243
R LRP L MK + + ++P + +V L+ I +F + G+ F+G G+
Sbjct 1127 NLRALRPLRALSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRC 1186
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
+G D + N+P L+ N + + + F +G+ +L
Sbjct 1187 INGTDINKYFNASNVPNQSQCLV-----------------SNYTWKVPNVNFDNVGNAYL 1229
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
L A ++G+L + ++ R + AFE F L
Sbjct 1230 ALLQVA----TYKGWL-DIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIF---GSFFTL 1281
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
+ V +D+ ++Q + + G + EE +K +N + + K+ P+ P +
Sbjct 1282 NLFIGVIIDNFNQQ----QKKLGGQDIFMTEEQKKYYNAMKKLGTKK--PQKPIPRPLNK 1335
Query 424 SAQFLF---GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
F+F FD + + + N++ ++ +++ P E I ILN VF+V +
Sbjct 1336 CQAFVFDLVTSQVFDVIILGLIVTNMI----IMMAESEGQPNEV-KKIFDILNIVFVVIF 1390
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+E L+KVFAL + Y + N+FD ++ V+ ++ + + + P + ++ L
Sbjct 1391 TVECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSGLENSNV---FPPTLFRIVRL 1446
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ R +R + +M + ++ G +L +V +++AI G+N
Sbjct 1447 ARIGRILRLVRAARGIRTLLFALMM---------SLPSLFNIGLLLFLVMFIYAIFGMNW 1497
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F V + NFD F+ +++ L+ + W L+
Sbjct 1498 FSKVKRGSGIDD--------------------IFNFDTFSGSMLCLFQITTSAGWDALLN 1537
Query 661 AYRRYSGPWSK-------------IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
+ +YFV + ++S +I VN+++A+ILENF +
Sbjct 1538 PMLESKASCNSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDP 1597
Query 708 QPLAG-----------TPEATYQMTVELL--FRDILEEP 733
PEAT + L F D L EP
Sbjct 1598 LGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPEP 1636
Score = 218 bits (555), Expect = 5e-58, Method: Composition-based stats.
Identities = 60/353 (17%), Positives = 128/353 (36%), Gaps = 43/353 (12%)
Query 406 SVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD 465
+K+ P + + ++ + H +F+ + L S + D ++ +
Sbjct 1010 KTIKKKSPWVLWWN-LRKTCYQIVKHSWFESFIIFVILL---SSGALIFEDVNLPSRPQV 1065
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ +L + +F +LLEM+LK A G R Y + D L+ VV +
Sbjct 1066 EKLLKCTDNIFTFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLS---------- 1115
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
L+ + L R LR + + M VV + ++ + + +
Sbjct 1116 ------------LTNLPNLKSFRNLRALRPLRALSQFEGMKVVVNALMSAIPAILNVLLV 1163
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ-------LEYWANNFDD 638
++ + +F I+G+N F G + + ++ + Q + NFD+
Sbjct 1164 CLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQCLVSNYTWKVPNVNFDN 1223
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNL 688
A + L + W ++A G ++ +YFV++ + S +NL
Sbjct 1224 VGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIFGSFFTLNL 1283
Query 689 FLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTER 741
F+ +I++NF + + Y ++ L ++P L +
Sbjct 1284 FIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKC 1336
Score = 206 bits (524), Expect = 4e-54, Method: Composition-based stats.
Identities = 105/701 (15%), Positives = 217/701 (31%), Gaps = 150/701 (21%)
Query 129 EVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL 184
E + + ++ + +K G+ + ++ W +V+ ++ + + L
Sbjct 162 EYVFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCFLGNKVNNLSTL 221
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R R+LR + S +K + + S+ ++ V +L L +F + G LF G
Sbjct 222 RTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQ 281
Query 245 DGQDRE------------------------------------------------RLTYFQ 256
+ T F
Sbjct 282 KCIKDDCGPNAFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGSTCNKTTFNPDYNYTNFD 341
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI-GSLFLMNLLTAIIYSQF 315
+ S ++ ++T + + + Y +FF V + GS +L+NL A++ +
Sbjct 342 SFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLAVVTMAY 401
Query 316 RGYLMKSLQTSLFRRRLGTRAAF------EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ + ++ A E L +M + + +
Sbjct 402 EEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTSLNSLQASSFSPKKRKFFGS 461
Query 370 QL--------DSSHKQAMMEKVRSYGSVLLSAEEFQKLFN-------------------- 401
+ + + + + E+ ++L
Sbjct 462 KTRKSFFMRGSKTARASASDSEDDASKNPQLLEQTKRLSQNLPVELFDEHVDPLHRQRAL 521
Query 402 --------ELDRSVVKEHPPRPEYQS-----------PFLQSAQFLFGHYYFDYLGNLIA 442
+ + P P ++ P + + D L
Sbjct 522 SAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKKVLQTIMTDPFTELAI 581
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
++ VFL ++ + D IL I N VF ++ EM LK+ AL Y + N
Sbjct 582 TICIIVNTVFLAMEHHNMDNSLKD-ILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWN 640
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
+FD ++ +V L + L L L V R ++ S
Sbjct 641 IFDSIVALVSLADVL-------------------FHKLSKNLSFLASLRVLRVFKLAKSW 681
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
+ + + V + +L +V ++F+++G+ LF S
Sbjct 682 PTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGAKFNKTCSTS---------- 731
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVS 681
E L W DF + + ++ ++ + + + G P I FVL +V
Sbjct 732 ---PESLRRWHMG--DFYHSFLVVFRILCGEWIENMWECMQEMEGSPLCVIVFVLIMVVG 786
Query 682 SVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
++ +NLF+AL+L +F ++ G PE + T
Sbjct 787 KLVVLNLFIALLLNSFSNEEK--------DGNPEGETRKTK 819
Score = 141 bits (354), Expect = 5e-33, Method: Composition-based stats.
Identities = 55/341 (16%), Positives = 125/341 (37%), Gaps = 35/341 (10%)
Query 48 QAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQR----TLSFTIFLILFLAFIETPS 103
Q + E+ +Y + ++ N CQ ++ +F ++ L I T
Sbjct 1302 QDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVTNM 1361
Query 104 SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLV 163
+ + + + ++ +++F + +K + + N W L V
Sbjct 1362 IIMMAESEGQP----NEVKKIFDILNIVFVVIFTVECLIKVFALRQH-YFTNGWNLFDCV 1416
Query 164 VLVVSLVD-------WTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEM 216
V+V+S++ + +R+ R+ R L++ + ++ L + SLP +
Sbjct 1417 VVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSL 1476
Query 217 ASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
++GLLL + + ++ +FGM F+ K+ G D + F S+ L + T+A
Sbjct 1477 FNIGLLLFLVMFIYAIFGMNWFSKVKRGSGID--DIFNFDTFSGSMLCLFQITTSAGWDA 1534
Query 277 VMIPAYSKNRAYA--------------IFFIVFTVIGSLFLMNLLTAIIYSQFR---GYL 319
++ P + ++F+ + +I L ++N+ A+I F
Sbjct 1535 LLNPMLESKASCNSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILENFNTATEES 1594
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
L F F+ ++ + + P+
Sbjct 1595 EDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPE 1635
Score = 133 bits (335), Expect = 1e-30, Method: Composition-based stats.
Identities = 64/340 (19%), Positives = 118/340 (35%), Gaps = 61/340 (18%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
PF F+ I ++ C+F+ ++ V + I VFI
Sbjct 114 PFNPIRSFMIRISVHSVFSMFIICTVII-NCMFMANNSSVDSRPSSN----IPEYVFIGI 168
Query 480 YLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
Y+LE ++K+ A G YL P N D ++ + P + V
Sbjct 169 YVLEAVIKILARGFIVDEFSYLRDPWNWLDFIV-------------IGTAIAPCFLGNKV 215
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
LS L V R L+ I + + V+ +L V+ + + + +FA+
Sbjct 216 NNLS------TLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFAL 269
Query 596 IGINLFRGVIVALPGNSS------------------------------LAPANGSAPCGS 625
+G LF G++ + +GS +
Sbjct 270 VGQQLFMGILSQKCIKDDCGPNAFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGSTCNKT 329
Query 626 FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIW 685
+Y NFD F + + ++ +M ++W+ R SG + +FV+ + S
Sbjct 330 TFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSFYL 389
Query 686 VNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+NL LA++ ++ R+ E +Q +LL
Sbjct 390 LNLTLAVV--TMAYEEQNRNVAAETEAK-EKMFQEAQQLL 426
>sp|O88457|SCNBA_RAT Sodium channel protein type 11 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn11a PE=1 SV=1
Length=1765
Score = 490 bits (1261), Expect = 6e-153, Method: Composition-based stats.
Identities = 130/702 (19%), Positives = 263/702 (37%), Gaps = 105/702 (15%)
Query 64 HRVDASSM-WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC 122
H+ D W+ C + + + F + I S DV
Sbjct 1008 HKTDKRKSPWVLWWNIRKTCYQIVKHSWFESFIIFVILLSSGALIFEDV--NLPSRPQVE 1065
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHE 182
L + + +F ++ +K FG+ + + W +++VVS++ ++L +
Sbjct 1066 KLLRCTDNIFTFIFLLEMILKWVAFGFRRYFTSAWCWLDFLIVVVSVLSL---MNLPSLK 1122
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG-- 240
R R LRP L MK + + ++P + +V L+ I +F + G+ LF+G
Sbjct 1123 SFRTLRALRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKF 1182
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
G+ +G D F +P N ++ + + F +G+
Sbjct 1183 GRCINGTDINMYLDFTEVPN-----------------RSQCNISNYSWKVPQVNFDNVGN 1225
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
+L L A ++G+L + + ++ R + FE F
Sbjct 1226 AYLALLQVA----TYKGWL-EIMNAAVDSREKDEQPDFEANLYAYLYFVVFIIF---GSF 1277
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
L + V +D+ ++Q + + G + EE +K +N + + K+ P+ P
Sbjct 1278 FTLNLFIGVIIDNFNQQ----QKKLGGQDIFMTEEQKKYYNAMKKLGTKK--PQKPIPRP 1331
Query 421 FLQSAQFLF---GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+ F+F FD + + + N++ +++ + ILN F+
Sbjct 1332 LNKCQAFVFDLVTSQVFDVIILGLIVLNMI-----IMMAESADQPKDVKKTFDILNIAFV 1386
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
V + +E L+KVFAL + Y + N+FD ++ V+ ++ + + + P + +
Sbjct 1387 VIFTIECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDIS--FPPTLFRV 1443
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ L + R+L ++ R +R + +M + ++ G +L +V +++AI G
Sbjct 1444 VRLARIGRILRLVRAARGIRTLLFALMM---------SLPSLFNIGLLLFLVMFIYAIFG 1494
Query 598 INLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
++ F V + NF+ F +++ L+ + W
Sbjct 1495 MSWFSKVKKGSGIDD--------------------IFNFETFTGSMLCLFQITTSAGWDT 1534
Query 658 FLDAYRRYSGPWSK-------------IYFVLWWLVSSVIWVNLFLALILENFLHKWDPR 704
L+ + +YFV + ++S +I VN+++A+ILENF +
Sbjct 1535 LLNPMLEAKEHCNSSSQDSCQQPQIAVVYFVSYIIISFLIVVNMYIAVILENFNTATEES 1594
Query 705 SHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
PEA+ + L F D L EP
Sbjct 1595 EDPLGEDDFEIFYEVWEKFDPEASQFIQYSALSDFADALPEP 1636
Score = 217 bits (553), Expect = 8e-58, Method: Composition-based stats.
Identities = 63/350 (18%), Positives = 124/350 (35%), Gaps = 43/350 (12%)
Query 409 KEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI 468
K P + + ++ + H +F+ + L S + D ++ + + +
Sbjct 1012 KRKSPWVLWWN-IRKTCYQIVKHSWFESFIIFVILL---SSGALIFEDVNLPSRPQVEKL 1067
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L + +F +LLEM+LK A G R Y + D L+ VV ++
Sbjct 1068 LRCTDNIFTFIFLLEMILKWVAFGFRRYFTSAWCWLDFLIVVVSVLS------------- 1114
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
L + L R LR + + M VV ++ + + + ++
Sbjct 1115 ---------LMNLPSLKSFRTLRALRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLI 1165
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLA-------PANGSAPCGSFEQLEYWANNFDDFAA 641
+ VF I+G+NLF G + + N S S + NFD+
Sbjct 1166 FWLVFCILGVNLFSGKFGRCINGTDINMYLDFTEVPNRSQCNISNYSWKVPQVNFDNVGN 1225
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLA 691
A + L + W ++A ++ +YFV++ + S +NLF+
Sbjct 1226 AYLALLQVATYKGWLEIMNAAVDSREKDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIG 1285
Query 692 LILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTER 741
+I++NF + + Y ++ L ++P L +
Sbjct 1286 VIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKC 1335
Score = 203 bits (515), Expect = 6e-53, Method: Composition-based stats.
Identities = 106/710 (15%), Positives = 211/710 (30%), Gaps = 143/710 (20%)
Query 129 EVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL 184
E + + ++ + +K G+ F ++ W +V+ ++ S V L
Sbjct 160 EYVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDFIVIGTAIATCFPG-SQVNLSAL 218
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R R+ R + S +K + + S+ ++ V +L L +F + G LF G
Sbjct 219 RTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQ 278
Query 245 DG------------------------------------------------QDRERLTYFQ 256
T F
Sbjct 279 KCIKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPNGSTCDKTTLNPDNNYTKFD 338
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI-GSLFLMNLLTAIIYSQF 315
N S ++ ++T + + + Y +FF V + GS +L+NL A++ +
Sbjct 339 NFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLAVVTMAY 398
Query 316 RGYLMKSLQTSLFRRRLGTRAAF------EVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ + ++ A E L +M + + +
Sbjct 399 EEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRSSLNSLQASSFSPKKRKFFGS 458
Query 370 QLDSSHK---QAMMEKVRSYGSVLLSAEEF-------------QKLFNE----------- 402
+ S + S S LF+E
Sbjct 459 KTRKSFFMRGSKTAQASASDSEDDASKNPQLLEQTKRLSQNLPVDLFDEHVDPLHRQRAL 518
Query 403 ---------LDRSVVKEHPPRPEYQS-----------PFLQSAQFLFGHYYFDYLGNLIA 442
+ + P P ++ P + + D L
Sbjct 519 SAVSILTITMQEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKKVLRTIMTDPFTELAI 578
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
++ VFL ++ + IL I N VF ++ EM LK+ AL Y + N
Sbjct 579 TICIIINTVFLAVEHHNMDDNL-KTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWN 637
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
VFD ++ ++ L + + L L V R ++ S
Sbjct 638 VFDSIVALLSLADVLYNTLSD------------------NNRSFLASLRVLRVFKLAKSW 679
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
+ + + V + +L +V ++F+++G+ LF + P
Sbjct 680 PTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGTKFNKTAYATQERPRRRWHM 739
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR--YSGPWSKIYFVLWWLV 680
D+F + + ++ ++ W + + P I FVL ++
Sbjct 740 --------------DNFYHSFLVVFRILCGE-WIENMWGCMQDMDGSPLCIIVFVLIMVI 784
Query 681 SSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDIL 730
++ +NLF+AL+L +F ++ S T F +L
Sbjct 785 GKLVVLNLFIALLLNSFSNEEKDGSLEGETRKTKVQLALDRFRRAFSFML 834
Score = 124 bits (312), Expect = 7e-28, Method: Composition-based stats.
Identities = 62/341 (18%), Positives = 115/341 (34%), Gaps = 67/341 (20%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + H F + N C+F+ + F I VFI
Sbjct 116 NPLRSLMIRISVHSVFSMFIICTVIIN----CMFMANSME------RSFDNDIPEYVFIG 165
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y+LE ++K+ A G +L P N D ++ + +
Sbjct 166 IYILEAVIKILARGFIVDEFSFLRDPWNWLDFIV-------------IGTAIATCFPGSQ 212
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
V L + L VFR L+ I + + V+ +L V+ + + + +FA
Sbjct 213 VNLSA-------LRTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFA 265
Query 595 IIGINLFRGVIVALPGN------------------------------SSLAPANGSAPCG 624
++G LF G++ S NGS
Sbjct 266 LVGQQLFMGILNQKCIKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPNGSTCDK 325
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVI 684
+ + FD+F + + ++ +M ++W+ R SG + +FV+ + S
Sbjct 326 TTLNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVVIFLGSFY 385
Query 685 WVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+NL LA++ ++ R+ E +Q +LL
Sbjct 386 LLNLTLAVV--TMAYEEQNRNVAAETEAK-EKMFQEAQQLL 423
Score = 107 bits (268), Expect = 1e-22, Method: Composition-based stats.
Identities = 48/250 (19%), Positives = 97/250 (39%), Gaps = 10/250 (4%)
Query 81 VCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-EVLCLLVFAAD 139
+C + + TI F T + +T + + + + +F A+
Sbjct 559 LCIKKVLRTIMTDPFTELAITICIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAE 618
Query 140 LSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS-LSLVCHEPLRIRRLLRPFFLLQN 198
+ +K H+ ++ W + +V ++SL D + LS L R+LR F L ++
Sbjct 619 MCLKIIALDPYHYFRHGWNVFDSIVALLSLADVLYNTLSDNNRSFLASLRVLRVFKLAKS 678
Query 199 SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK----QDDGQDRERLTY 254
+ +K I S+ + ++ ++L I + +F++ GM LF + R +
Sbjct 679 WPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGTKFNKTAYATQERPRRRWH 738
Query 255 FQNLPESLTSLLVLLTTANNPDVMIPA---YSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
N S + +L + M + I F++ VIG L ++NL A++
Sbjct 739 MDNFYHSFLVVFRILCGE-WIENMWGCMQDMDGSPLCIIVFVLIMVIGKLVVLNLFIALL 797
Query 312 YSQFRGYLMK 321
+ F
Sbjct 798 LNSFSNEEKD 807
>sp|P35500|SCNA_DROME Sodium channel protein para OS=Drosophila
melanogaster OX=7227 GN=para PE=2 SV=3
Length=2131
Score = 479 bits (1232), Expect = 2e-147, Method: Composition-based stats.
Identities = 132/703 (19%), Positives = 262/703 (37%), Gaps = 105/703 (15%)
Query 67 DASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTE 126
D S W + + F + I S + DV P +
Sbjct 1279 DDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQD--ILY 1336
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS----LVCHE 182
++ + ++F ++ +K G+ + N W V+++VSL+++ SL + +
Sbjct 1337 YMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFK 1396
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
+R R LRP + M+ + + ++P + +V L+ I +F + G+ LFAG
Sbjct 1397 TMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGK- 1455
Query 243 QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLF 302
YF+ + T L + N S+N + + F +G+ +
Sbjct 1456 -----------YFKCEDMNGTKLSHEIIPNRNA-----CESENYTWVNSAMNFDHVGNAY 1499
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
L A F+G++ + + ++ R + + E M F
Sbjct 1500 LCLFQVA----TFKGWI-QIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIF---GSFFT 1551
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L + V +D+ ++Q +K + E+ +K +N + + K+
Sbjct 1552 LNLFIGVIIDNFNEQ---KKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP 1608
Query 423 QSAQF-LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
Q+ F + FD + L N+ ++ + +D + +L LN +F+V +
Sbjct 1609 QAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTY-----NAVLDYLNAIFVVIFS 1663
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW-RPEMVGLLSL 540
E LLK+FAL Y P N+FD VV+++L I L + + + P ++ ++ +
Sbjct 1664 SECLLKIFALRY-HYFIEPWNLFD----VVVVILSILGLVLSDIIEKYFVSPTLLRVVRV 1718
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ R+L ++ + +R + M + + +L +V ++FAI G++
Sbjct 1719 AKVGRVLRLVKGAKGIRTLLFALAM---------SLPALFNICLLLFLVMFIFAIFGMSF 1769
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F V N NF F +++ L+ + W LD
Sbjct 1770 FMHVKEKSGIND--------------------VYNFKTFGQSMILLFQMSTSAGWDGVLD 1809
Query 661 AY------------RRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
A + Y G + + + ++S +I +N+++A+ILEN+ +
Sbjct 1810 AIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATED 1869
Query 704 RSHLQPLAG-----------TPEATYQMTVELL--FRDILEEP 733
PE T + + L F D+LE P
Sbjct 1870 VQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPP 1912
Score = 236 bits (603), Expect = 4e-64, Method: Composition-based stats.
Identities = 66/343 (19%), Positives = 131/343 (38%), Gaps = 34/343 (10%)
Query 399 LFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDAD 458
+ + + P + L + YF+ + L + +++ + D
Sbjct 1268 YYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALE---DVH 1324
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIS 518
+ IL ++ +F V + LEML+K ALG + Y + D ++ +V L+ ++
Sbjct 1325 LPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVA 1384
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
+L + + L R LR + M+ M VV + ++ + +
Sbjct 1385 SLVGAGGI---------------QAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPS 1429
Query 579 MRAFGGILVVVYYVFAIIGINLFRGVIVALPG-NSSLAPANGSAPCGSFEQLEY-WAN-- 634
+ + ++ + +FAI+G+ LF G N + + E Y W N
Sbjct 1430 IFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSA 1489
Query 635 -NFDDFAAALVTLWNLMVVNNW-QVFLDAY---------RRYSGPWSKIYFVLWWLVSSV 683
NFD A + L+ + W Q+ DA R + + +YFV + + S
Sbjct 1490 MNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSF 1549
Query 684 IWVNLFLALILENFLH-KWDPRSHLQPLAGTPEATYQMTVELL 725
+NLF+ +I++NF K L+ + Y ++ +
Sbjct 1550 FTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKM 1592
Score = 136 bits (343), Expect = 2e-31, Method: Composition-based stats.
Identities = 57/324 (18%), Positives = 105/324 (32%), Gaps = 84/324 (26%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A ++ H F L N + + + + +F
Sbjct 140 NPIRRVAIYILVHPLFSLFIITTILVNCILMIM------------PTTPTVESTEVIFTG 187
Query 479 YYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E +KV A G YL N D ++ L + ++
Sbjct 188 IYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVI--------------ALAYVTMGIDL 233
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + L V R L+ + + + + V+ V+N+R + + VFA
Sbjct 234 GNLAA-------LRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFA 286
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN------------------- 635
++G+ ++ GV+ P +GS + E +Y N
Sbjct 287 LMGLQIYMGVLTQKCI--KKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNI 344
Query 636 --------------------------FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
FD F A ++ + LM + W+ R +GPW
Sbjct 345 SGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPW 404
Query 670 SKIYFVLWWLVSSVIWVNLFLALI 693
++F++ + S VNL LA++
Sbjct 405 HMLFFIVIIFLGSFYLVNLILAIV 428
Score = 131 bits (330), Expect = 6e-30, Method: Composition-based stats.
Identities = 49/304 (16%), Positives = 118/304 (39%), Gaps = 36/304 (12%)
Query 54 EDAIQYRSINHRVDASS----MWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTA 109
ED +Y + ++ + + R + ++ F I+ + FI +
Sbjct 1580 EDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLD 1639
Query 110 DVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSL 169
R + + + + + +++F+++ +K + + + W L +VV+++S+
Sbjct 1640 ----RYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYH-YFIEPWNLFDVVVVILSI 1694
Query 170 VDWTV-------SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLL 222
+ + +S +R+ ++ R L++ + ++ L + SLP + ++ LL
Sbjct 1695 LGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLL 1754
Query 223 LAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANN-------- 274
L + + +F +FGM F K+ G + F+ +S+ L + T+A
Sbjct 1755 LFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQSMILLFQMSTSAGWDGVLDAII 1812
Query 275 ---------PDVMIPAYSKNRAYAIFFIV-FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQ 324
D P + I F++ + VI L ++N+ A+I + +
Sbjct 1813 NEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQE 1872
Query 325 TSLF 328
Sbjct 1873 GLTD 1876
Score = 122 bits (307), Expect = 3e-27, Method: Composition-based stats.
Identities = 40/257 (16%), Positives = 88/257 (34%), Gaps = 42/257 (16%)
Query 429 FGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
FD L +V +F+ +D + E + +L N F + +E +K+
Sbjct 811 VSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMER-VLKSGNYFFTATFAIEATMKL 869
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
A+ + Y N+FD ++ + L + + L+
Sbjct 870 MAMSPKYYFQEGWNIFDFIIV-----------------------ALSLLELGLEGVQGLS 906
Query 549 MLIVFRFLRIIPSMKLM---AVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+L FR LR+ K ++ S + + + +L ++ ++FA++G+ LF
Sbjct 907 VLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK-- 964
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
N F + NF DF + + ++ ++ W +
Sbjct 965 ------------NYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYV 1011
Query 666 SGPWSKIYFVLWWLVSS 682
+F+ ++ +
Sbjct 1012 GDVSCIPFFLATVVIGN 1028
Score = 95.2 bits (235), Expect = 1e-18, Method: Composition-based stats.
Identities = 33/227 (15%), Positives = 74/227 (33%), Gaps = 7/227 (3%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+ + +S +F FI + + + + +S
Sbjct 802 WVWLKFQEW-VSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTAT 860
Query 136 FAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFL 195
FA + ++K ++ + W + +++ + + LR RLLR F L
Sbjct 861 FAIEATMKLMAMSPKYYFQEGWNIFDFIIV-ALSLLELGLEGVQGLSVLRSFRLLRVFKL 919
Query 196 LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD----DGQDRER 251
++ + + + ++ + ++ +L I + +F + GM LF D
Sbjct 920 AKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLP 979
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI 298
F + S + +L + M I F + TV+
Sbjct 980 RWNFTDFMHSFMIVFRVLCGE-WIESMWDCMYVGDVSCIPFFLATVV 1025
Score = 89.8 bits (221), Expect = 6e-17, Method: Composition-based stats.
Identities = 27/131 (21%), Positives = 53/131 (40%), Gaps = 6/131 (5%)
Query 120 PPCGLTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVS 175
P ES EV+ ++ + +VK G+ + ++ W VV ++L T+
Sbjct 173 PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVV--IALAYVTMG 230
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+ L LR R+LR + +K + + S+ + V +L L +F + G+
Sbjct 231 IDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGL 290
Query 236 LLFAGGKQDDG 246
++ G
Sbjct 291 QIYMGVLTQKC 301
>sp|Q9UI33|SCNBA_HUMAN Sodium channel protein type 11 subunit
alpha OS=Homo sapiens OX=9606 GN=SCN11A PE=1 SV=2
Length=1791
Score = 473 bits (1218), Expect = 1e-146, Method: Composition-based stats.
Identities = 130/687 (19%), Positives = 256/687 (37%), Gaps = 94/687 (14%)
Query 72 WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
W+ C + + + F + I S DV P L +++
Sbjct 1039 WVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQE--LLNCTDII 1096
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLR 191
+F ++ +K FG+ + + W ++++VS+ T ++L+ + R R LR
Sbjct 1097 FTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSV---TTLINLMELKSFRTLRALR 1153
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P L MK + + ++P + +V L+ I +F + G+ F+G +
Sbjct 1154 PLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDS 1213
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
+ + + S N ++ + F +G+ +L L A
Sbjct 1214 VINYTIITN-----------------KSQCESGNFSWINQKVNFDNVGNAYLALLQVA-- 1254
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
F+G+ M + ++ + FE S F L + V +
Sbjct 1255 --TFKGW-MDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIF---GSFFTLNLFIGVII 1308
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
D+ ++Q + + G + EE +K +N + + K+ P+ P + +F
Sbjct 1309 DNFNQQ----QKKLGGQDIFMTEEQKKYYNAMKKLGSKK--PQKPIPRPLNKCQGLVFDI 1362
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
+I ++++ + + IL LN VF+V + LE L+K+FAL
Sbjct 1363 VTSQIFDIIIISLIILNMISMMAES--YNQPKAMKSILDHLNWVFVVIFTLECLIKIFAL 1420
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+ Y + N+FD + V+L ++ + H + P + ++ L + R+L ++
Sbjct 1421 R-QYYFTNGWNLFDC-VVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVR 1478
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
R +R + +M + ++ G +L ++ +++AI+G+N F V
Sbjct 1479 AARGIRTLLFALMM---------SLPSLFNIGLLLFLIMFIYAILGMNWFSKV------- 1522
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
+ E NF FA++++ L+ + W L R +
Sbjct 1523 -------------NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNS 1569
Query 672 ------------IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG------- 712
YFV + ++S +I VN+++A+ILENF +
Sbjct 1570 SSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEV 1629
Query 713 ----TPEATYQMTVELL--FRDILEEP 733
PEAT + L F D L EP
Sbjct 1630 WEKFDPEATQFIKYSALSDFADALPEP 1656
Score = 223 bits (568), Expect = 1e-59, Method: Composition-based stats.
Identities = 58/347 (17%), Positives = 119/347 (34%), Gaps = 40/347 (12%)
Query 410 EHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
+ P ++ + H +F+ + L S + D + + +L
Sbjct 1034 KRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILL---SSGALIFEDVHLENQPKIQELL 1090
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
+ +F ++LEM+LK A G Y + D ++ +V + I+ + +
Sbjct 1091 NCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINLMEL------- 1143
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+ L R LR + + M VV + ++G + + + ++
Sbjct 1144 ---------------KSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIF 1188
Query 590 YYVFAIIGINLFRGVIVAL--PGNSSLAPANGSAPCGSFEQLEYWAN---NFDDFAAALV 644
+ VF I+G+ F G +S + + W N NFD+ A +
Sbjct 1189 WLVFCILGVYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYL 1248
Query 645 TLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLALIL 694
L + W + A + IYFV++ + S +NLF+ +I+
Sbjct 1249 ALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVII 1308
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTER 741
+NF + + Y ++ L ++P L +
Sbjct 1309 DNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKC 1355
Score = 220 bits (561), Expect = 9e-59, Method: Composition-based stats.
Identities = 104/731 (14%), Positives = 222/731 (30%), Gaps = 144/731 (20%)
Query 116 APWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVD 171
T+ E + ++ + +K G+ F ++ W +V+ +++V
Sbjct 150 PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVS 209
Query 172 WTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
+ +++ PLR R+ R + S +K + + S+ ++ +V +L L +F
Sbjct 210 YIPGITIKLL-PLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFA 268
Query 232 MFGMLLFAGG-------------------------------------------------- 241
+ G LF G
Sbjct 269 LVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYEC 328
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGS 300
K T F N S ++ L+T + + + FFIV +GS
Sbjct 329 KHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGS 388
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
+L+NL A++ + + + + + A ++L A
Sbjct 389 FYLINLTLAVVTMAYEEQNKN-VAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTS 447
Query 361 NLLQVLQKVQLDSS-HKQAMMEKVRSYGSVLLSAEEFQKLFNE----------------- 402
+ +K+ +R G + + +
Sbjct 448 LETSYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSL 507
Query 403 -------------------------LDRSVVKEHPPRPEYQS-----------PFLQSAQ 426
+ + P P ++ P +
Sbjct 508 DHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVK 567
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
+ D L ++ VFL ++ + A + +L I N VF ++ EM L
Sbjct 568 KVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEK-MLNIGNLVFTSIFIAEMCL 626
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K+ AL Y N+FD + +L ++ + + P
Sbjct 627 KIIALDPYHYFRRGWNIFDS-IVALLSFADVMNCVLQKRSWPF----------------- 668
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L V R ++ S + + + V + + +LV+V ++F+++G+ LF
Sbjct 669 LRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFN 728
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
+ P + C + DF + + ++ ++ W + + +
Sbjct 729 SQKSPKLCNPTGPTVSCLRHWHMG-------DFWHSFLVVFRILCGE-WIENMWECMQEA 780
Query 667 GPWSK---IYFVLWWLVSSVIWVNLFLALILENFLHK---WDPRSHLQPLAGTPEATYQM 720
S I F+L ++ ++ +NLF+AL+L +F ++ + +
Sbjct 781 NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR 840
Query 721 TVELLFRDILE 731
R LE
Sbjct 841 RAFCFVRHTLE 851
Score = 145 bits (365), Expect = 2e-34, Method: Composition-based stats.
Identities = 61/343 (18%), Positives = 114/343 (33%), Gaps = 66/343 (19%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ A + H F + N CVF+ + I CVF
Sbjct 116 NSIRSLAIRVSVHSLFSMFIIGTVIIN----CVFMATGPAKNSNSNNT---DIAECVFTG 168
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y+ E L+K+ A G +L P N D ++ + +V I + + LP
Sbjct 169 IYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP-------- 220
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L VFR L+ I + + V+ +L V+ + + +FA
Sbjct 221 ------------LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFA 268
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCG------------------------------ 624
++G LF G + + +
Sbjct 269 LVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYEC 328
Query 625 --SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS 682
+ +Y NFD+F + + ++ LM ++W+ R +G +S +F++ + S
Sbjct 329 KHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGS 388
Query 683 VIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+NL LA++ + + + E +Q +LL
Sbjct 389 FYLINLTLAVVTMAYEEQNKNVA---AEIEAKEKMFQEAQQLL 428
>sp|P15381|CAC1C_RABIT Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Oryctolagus cuniculus OX=9986 GN=CACNA1C
PE=1 SV=1
Length=2171
Score = 449 bits (1154), Expect = 9e-137, Method: Composition-based stats.
Identities = 118/645 (18%), Positives = 258/645 (40%), Gaps = 77/645 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C R ++ TIF L L FI S + D + + +++ +F
Sbjct 918 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRN---HILFYFDIVFTTIF 974
Query 137 AADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLR 191
++++K +G F +N + + L+V+ VSL+ + + S + + LR+ R+LR
Sbjct 975 TIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLR 1034
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1035 PLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG-KLYTCSDSSK 1093
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
Q E + + + ++ P +N + ++ +M L T
Sbjct 1094 ----QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVL------AAMMALFT--- 1140
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ + L S+ T + + V F + + ++ + +
Sbjct 1141 VSTFEGWP-ELLYRSIDS---HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1196
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ +Q E Y + L + Q + L ++ + P+ ++Q ++
Sbjct 1197 VTFQEQGEQE----YKNCELDKNQRQCVEYALKARPLRRYIPKNQHQ----YKVWYVVNS 1248
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
YF+YL ++ L N +IC+ + + + ILN +F + +EM+LK+ A
Sbjct 1249 TYFEYLMFVLILLN--TICLAM---QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1303
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+GY S P NVFD L+ + ++++ H P M + +
Sbjct 1304 KPKGYFSDPWNVFDFLIVI-GSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFR 1362
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
V R ++++ + + + T + Q + ++V++++++A+IG+ +F +
Sbjct 1363 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------- 1415
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR--RYSGPW 669
+ NNF F A++ L+ WQ + A + P
Sbjct 1416 -----------ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1464
Query 670 SK-----------------IYFVLWWLVSSVIWVNLFLALILENF 697
S+ YF+ ++++ + + +NLF+A+I++NF
Sbjct 1465 SEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1509
Score = 377 bits (967), Expect = 9e-112, Method: Composition-based stats.
Identities = 123/739 (17%), Positives = 262/739 (35%), Gaps = 133/739 (18%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I+ L I + + + E VE L L++F
Sbjct 143 IRRACISIVEWKPFEIIILLTIFANCVALAIY-IPFPEDDSNATNSNLERVEYLFLIIFT 201
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC------------- 180
+ +K G LF + +N W L +++VV L + +
Sbjct 202 VEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 261
Query 181 -HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 262 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 321
Query 240 GGKQDDGQDRER---------------------------------------LTYFQNLPE 260
G ++E +T F N
Sbjct 322 GKMHKTCYNQEGVADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAF 381
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF 315
++ ++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 382 AMLTVFQCITMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 438
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ-LDSS 374
K+ F++ R ++ + G QA + P+N + + + + + S
Sbjct 439 SKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMS 495
Query 375 HKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ E V + G + +L + + +S + R + + +
Sbjct 496 MPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCRRKCRAAVKS 553
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F +L + N ++I L + N + + EMLLK+++L
Sbjct 554 NVFYWLVIFLVFLNTLTIASEHYNQPHWLTE-----VQDTANKALLALFTAEMLLKMYSL 608
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
GL+ Y N FD + ++ I + + +++L
Sbjct 609 GLQAYFVSLFNRFDCFIVCGGILETIL------------------VETKVMSPLGISVLR 650
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII---GINLFRGVIVAL 608
R LRI + +++ V L+ ++R+ +L++++ I G+ LF G
Sbjct 651 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 707
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSG 667
+F++++ + FD+F +L+T++ ++ +W V D Y G
Sbjct 708 ----------------NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 751
Query 668 PWS-----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
P IYF++ ++ + I +N+FLA+ ++N + + L + +
Sbjct 752 PSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL-------ADAESLTSAQKEEEEEKE 804
Query 723 ELLFRDILEEPGEDELTER 741
+ E+ +
Sbjct 805 RKKLARTASPEKKQEVVGK 823
Score = 365 bits (937), Expect = 1e-107, Method: Composition-based stats.
Identities = 139/735 (19%), Positives = 275/735 (37%), Gaps = 87/735 (12%)
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFI 99
+ A IE + HR+ S Y R ++ C+R + +L++FL F+
Sbjct 507 ENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 566
Query 100 ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL- 158
T + A Y W ++ L +F A++ +K Y G + +L+
Sbjct 567 NT----LTIASEHYNQPHWLTEVQ--DTANKALLALFTAEMLLKMYSLGLQAYFVSLFNR 620
Query 159 LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+V ++ +++ T +S + LR RLLR F + + + + + + S+
Sbjct 621 FDCFIVCGGILETILVETKVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRS 680
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+AS+ LLL + + +F++ GM LF GGK + + + R + F N P+SL ++ +LT +
Sbjct 681 IASLLLLLFLFIIIFSLLGMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 739
Query 276 DVMIPAYSK-------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF---------RGYL 319
VM I+FI+ + G+ L+N+ AI +
Sbjct 740 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 799
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLD 372
+ + R EV+ E + A G P + +Q +
Sbjct 800 EEEKERKKLARTASPEKKQEVVGKPALEEAKEEKIELKSITADGESPPTTKINMDDLQPN 859
Query 373 SSHKQAMMEK-----VRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
S ++ + + +EL + P PE + F+ S
Sbjct 860 ESEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKE--KAVPMPEASAFFIFSPNN 917
Query 428 LFGHYYFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
F + + + L ++ + L + V + IL + VF + +E
Sbjct 918 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIE 977
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ LK+ A G +L S + + LLV+ +S ++ S ++
Sbjct 978 IALKMTAYG--AFLHKGSFCRNYFNILDLLVVSVSLISFGIQS------------SAINV 1023
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 1024 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG 1083
Query 604 VIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMV 651
+ +S A +++ Q W N +FD+ AA++ L+ +
Sbjct 1084 KLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVST 1143
Query 652 VNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKW 701
W L D++ GP +++ ++ + +N+F+ ++ F +
Sbjct 1144 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1203
Query 702 DPRSHLQPLAGTPEA 716
+ L
Sbjct 1204 EQEYKNCELDKNQRQ 1218
Score = 208 bits (530), Expect = 8e-55, Method: Composition-based stats.
Identities = 72/383 (19%), Positives = 145/383 (38%), Gaps = 47/383 (12%)
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QSPFLQ 423
+D++ + +M + +S+ + ++ + RP ++P +
Sbjct 86 IDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRR 145
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F+ + L AN V++ +++ D A + L + +F++ + +E
Sbjct 146 ACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA--TNSNLERVEYLFLIIFTVE 203
Query 484 MLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
LKV A G YL N+ D ++ VV L I A + G
Sbjct 204 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD- 262
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L V R LR++ + + VV ++++ + + +++ V ++AIIG+
Sbjct 263 ----VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 318
Query 600 LFRGVIVALPGNSS---------------------LAPANGSAPCGSFEQLEYWANNFDD 638
LF G + N NG+ ++ ++ NFD+
Sbjct 319 LFMGKMHKTCYNQEGVADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDN 378
Query 639 FAAALVTLWNLMVVNNWQV---FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
FA A++T++ + + W ++ Y PW +YFV + S +NL L ++
Sbjct 379 FAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVLGVLSG 436
Query 696 NF---LHKWDPRSHLQPLAGTPE 715
F K R Q L +
Sbjct 437 EFSKEREKAKARGDFQKLREKQQ 459
>sp|Q99246|CAC1D_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Mus musculus OX=10090 GN=Cacna1d PE=1
SV=3
Length=2179
Score = 448 bits (1153), Expect = 1e-136, Method: Composition-based stats.
Identities = 116/641 (18%), Positives = 245/641 (38%), Gaps = 77/641 (12%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 899 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILG---YFDYAFTAIFTVEIL 955
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 956 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1015
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYRCTDEAKSN--- 1071
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F F + S +M L T S F
Sbjct 1072 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDF-NFDNVLSA-MMALFT---VSTFE 1121
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
G+ L ++ V + V F + + ++ + + + +
Sbjct 1122 GWPA-LLYKAIDS---NGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1177
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P+ ++ F+Y
Sbjct 1178 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIP----KNPYQYKFWYVVNSSPFEY 1229
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + ++ + + ILN VF + +EM+LKV A +GY
Sbjct 1230 MMFVLIMLNTLCLAM-----QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1284
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM---TRMLNMLIVF 553
S N FD L+ + ++ + A P S + V
Sbjct 1285 FSDAWNTFDSLIVIGSIIDVALSEADPSESETIPLPTATPGNSEESNRISITFFRLFRVM 1344
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R ++++ + + + T + Q + ++ ++++++A+IG+ +F V + +
Sbjct 1345 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQIN 1404
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DAYRR 664
F F A++ L+ WQ + D
Sbjct 1405 RNNN------------------FQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSD 1446
Query 665 Y--------SGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1447 YNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487
Score = 355 bits (910), Expect = 3e-104, Method: Composition-based stats.
Identities = 128/757 (17%), Positives = 264/757 (35%), Gaps = 139/757 (18%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I L I + + + E VE L++F
Sbjct 115 IRRACISIVEWKPFDIFILLAIFANCVALAIY-IPFPEDDSNSTNHNLEKVEYAFLIIFT 173
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVS---------------LSL 178
+ +K +G + +N W L V+++V L +
Sbjct 174 VETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGG 233
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 234 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Query 239 AGGKQDDG-------------------------------------QDRERLTYFQNLPES 261
G +T F N +
Sbjct 294 IGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFA 353
Query 262 LTSLLVLLTTANNPDVMIPAYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y N ++F+ ++GS F++NL+ ++ +F
Sbjct 354 MLTVFQCITMEGWTDVL---YWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS 410
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA + P+N + ++ + ++S
Sbjct 411 KEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMP 467
Query 377 QAMMEKVRSYGSVLLSAE-EFQKLFNEL----DRSVVKEHPPRPEYQSPFLQSAQFL--- 428
+ E V + +S E E Q L R + P + S L
Sbjct 468 TSETESVNTEN---VSGEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKSKLSRR 524
Query 429 ---------------FGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
F +L ++ N ++I D L I I N
Sbjct 525 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWL-----TQIQDIAN 579
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
V + + EML+K+++LGL+ Y N FD + + I + P
Sbjct 580 KVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETIL------VELELMSPL 633
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
V + + + R ++ ++ + +++L ++++ + +L + +F
Sbjct 634 GVSV---------FRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIF 684
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
+++G+ LF G +F++ + + FD+F AL+T++ ++
Sbjct 685 SLLGMQLFGGKF-------------------NFDETQTKRSTFDNFPQALLTVFQILTGE 725
Query 654 NWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
+W V D Y GP S IYF++ ++ + I +N+FLA+ ++N +
Sbjct 726 DWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 785
Query 708 QPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ A E E L +P +++ ++
Sbjct 786 KEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 822
Score = 295 bits (756), Expect = 5e-84, Method: Composition-based stats.
Identities = 126/716 (18%), Positives = 251/716 (35%), Gaps = 94/716 (13%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW 149
+L++ L F+ T + + Y W + L +F ++ VK Y G
Sbjct 546 YWLVIVLVFLNT----LTISSEHYNQPDWLTQIQDI--ANKVLLALFTCEMLVKMYSLGL 599
Query 150 AHFQKNLWL-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
+ +L+ VV + +++ +S + R RLLR F + ++ + +
Sbjct 600 QAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNL 659
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSL 265
+ + S+ +AS+ LLL + + +F++ GM LF GGK + + + + + F N P++L ++
Sbjct 660 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDETQTKRSTFDNFPQALLTV 718
Query 266 LVLLTTANNPDVMIPAY-------SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
+LT + VM S I+FI+ + G+ L+N+ AI
Sbjct 719 FQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD- 777
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
+SL T+ E E + + + KV +D + A
Sbjct 778 -AESLNTAQKEEAEEK----ERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEDA 832
Query 379 MME--------------KVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------EYQ 418
+ + + A + +EL+ P
Sbjct 833 EDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 892
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P L H+ F L + + + L + + + ILG + F
Sbjct 893 NPIRVGCHKLINHHIFTNLILVFIMLS----SAALAAEDPIRSHSFRNTILGYFDYAFTA 948
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ +E+LLK+ G + N+ D L+ V LV
Sbjct 949 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLV------------------SF 990
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + ++L +L V R LR I K + V V ++ + + ++ ++FA
Sbjct 991 GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1050
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ------------LEYWANNFDDFAAA 642
IG+ LF+G + P ++ + NFD+ +A
Sbjct 1051 CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSA 1110
Query 643 LVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLAL 692
++ L+ + W L D+ GP +++ ++ + +N+F+
Sbjct 1111 MMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGF 1170
Query 693 ILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDILEEPGEDELTERLSQHP 746
++ F + + L Y + L R I + P + + ++ P
Sbjct 1171 VIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSP 1226
Score = 212 bits (539), Expect = 5e-56, Method: Composition-based stats.
Identities = 71/383 (19%), Positives = 135/383 (35%), Gaps = 40/383 (10%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QS 419
Q + +A S + S + ++ + RP +
Sbjct 54 QAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNN 113
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++ + FD L AN V++ +++ D + + L + F++
Sbjct 114 PIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNS--TNHNLEKVEYAFLII 171
Query 480 YLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
+ +E LK+ A G Y+ N+ D ++ +V L I
Sbjct 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
G + + L V R LR++ + + VV ++++ + + +++ V ++AI
Sbjct 232 GGFDV----KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAI 287
Query 596 IGINLFRGVIVALP-------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IG+ LF G + GN ANG+ + NF
Sbjct 288 IGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNF 347
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILE 695
D+FA A++T++ + + W L G W +YFV ++ S +NL L ++
Sbjct 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
Query 696 NF---LHKWDPRSHLQPLAGTPE 715
F K R Q L +
Sbjct 408 EFSKEREKAKARGDFQKLREKQQ 430
>sp|Q01815|CAC1C_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Mus musculus OX=10090 GN=Cacna1c PE=1
SV=1
Length=2139
Score = 447 bits (1150), Expect = 3e-136, Method: Composition-based stats.
Identities = 119/645 (18%), Positives = 257/645 (40%), Gaps = 77/645 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C R ++ TIF L L FI S + D + G + + + +F
Sbjct 888 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILG---NADYVFTSIF 944
Query 137 AADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLR 191
++ +K +G F +N + + L+V+ VSL+ + + S + + LR+ R+LR
Sbjct 945 TLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLR 1004
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1005 PLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG-KLYTCSDSSK 1063
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
Q E + + + ++ P +N + ++ +M L T
Sbjct 1064 ----QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVL------AAMMALFT--- 1110
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ + L S+ T + + V F + + ++ + +
Sbjct 1111 VSTFEGWP-ELLYRSIDS---HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1166
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ +Q E Y + L + Q + L ++ + P+ ++Q ++
Sbjct 1167 VTFQEQGEQE----YKNCELDKNQRQCVEYALKARPLRRYIPKNQHQ----YKVWYVVNS 1218
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
YF+YL ++ L N +IC+ + + + ILN +F + +EM+LK+ A
Sbjct 1219 TYFEYLMFVLILLN--TICLAM---QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1273
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+GY S P NVFD L+ + ++++ H P M + +
Sbjct 1274 KPKGYFSDPWNVFDFLIVI-GSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFR 1332
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
V R ++++ + + + T + Q + ++V++++++A+IG+ +F +
Sbjct 1333 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------- 1385
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR--RYSGPW 669
+ NNF F A++ L+ WQ + A + P
Sbjct 1386 -----------ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1434
Query 670 SK-----------------IYFVLWWLVSSVIWVNLFLALILENF 697
S+ YF+ ++++ + + +NLF+A+I++NF
Sbjct 1435 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 377 bits (968), Expect = 8e-112, Method: Composition-based stats.
Identities = 124/739 (17%), Positives = 263/739 (36%), Gaps = 133/739 (18%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I+ L I + + + E VE L L++F
Sbjct 113 IRRACISIVEWKPFEIIILLTIFANCVALAIY-IPFPEDDSNATNSNLERVEYLFLIIFT 171
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC------------- 180
+ +K G LF + +N W L +++VV L + +
Sbjct 172 VEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 231
Query 181 -HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 232 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Query 240 GGKQDDGQDRE---------------------------------------RLTYFQNLPE 260
G ++E +T F N
Sbjct 292 GKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAF 351
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF 315
++ ++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 352 AMLTVFQCITMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 408
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL-QKVQLDSS 374
K+ F++ R ++ + G QA + P+N + + + + S
Sbjct 409 SKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMS 465
Query 375 HKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ E V + G + +L + + +S + R + + +
Sbjct 466 MPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCRRKCRAAVKS 523
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F +L + N ++I L + N + + EMLLK+++L
Sbjct 524 NVFYWLVIFLVFLNTLTIASEHYNQPHWLTE-----VQDTANKALLALFTAEMLLKMYSL 578
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
GL+ Y N FD + ++ I + + +++L
Sbjct 579 GLQAYFVSLFNRFDCFIVCGGILETIL------------------VETKIMSPLGISVLR 620
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVAL 608
R LRI + +++ V L+ ++R + +L + +F+++G+ LF G
Sbjct 621 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 677
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSG 667
+F++++ + FD+F +L+T++ ++ +W V D Y G
Sbjct 678 ----------------NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 721
Query 668 PWS-----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
P IYF++ ++ + I +N+FLA+ ++N + + L + +
Sbjct 722 PSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL-------ADAESLTSAQKEEEEEKE 774
Query 723 ELLFRDILEEPGEDELTER 741
+ E+ E+
Sbjct 775 RKKLARTASPEKKQEVMEK 793
Score = 367 bits (941), Expect = 3e-108, Method: Composition-based stats.
Identities = 141/735 (19%), Positives = 278/735 (38%), Gaps = 87/735 (12%)
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFI 99
+ A IE + HR+ S Y R ++ C+R + +L++FL F+
Sbjct 477 ENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 536
Query 100 ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL- 158
T + A Y W ++ L +F A++ +K Y G + +L+
Sbjct 537 NT----LTIASEHYNQPHWLTEVQ--DTANKALLALFTAEMLLKMYSLGLQAYFVSLFNR 590
Query 159 LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+V ++ +++ T +S + LR RLLR F + + + + + + S+
Sbjct 591 FDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRS 650
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+AS+ LLL + + +F++ GM LF GGK + + + R + F N P+SL ++ +LT +
Sbjct 651 IASLLLLLFLFIIIFSLLGMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709
Query 276 DVMIPAYSK-------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF---------RGYL 319
VM I+FI+ + G+ L+N+ AI +
Sbjct 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLD 372
+ + R EV+ E + A G P + +Q
Sbjct 770 EEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPS 829
Query 373 SSHKQAMMEKVRSYG-----SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ ++ + G + + +EL + P PE + F+ S
Sbjct 830 ENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKE--KAVPMPEASAFFIFSPNN 887
Query 428 LFGHYYFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
F + + + L ++ + L + V + ILG + VF + LE
Sbjct 888 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLE 947
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
++LK+ A G +L S + + LLV+ +S ++ S ++
Sbjct 948 IILKMTAYG--AFLHKGSFCRNYFNILDLLVVSVSLISFGIQS------------SAINV 993
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 994 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG 1053
Query 604 VIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMV 651
+ +S A +++ Q W N +FD+ AA++ L+ +
Sbjct 1054 KLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVST 1113
Query 652 VNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKW 701
W L D++ GP +++ ++ + +N+F+ ++ F +
Sbjct 1114 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1173
Query 702 DPRSHLQPLAGTPEA 716
+ L
Sbjct 1174 EQEYKNCELDKNQRQ 1188
>sp|O35505|CAC1C_CAVPO Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Cavia porcellus OX=10141 GN=CACNA1C PE=1
SV=2
Length=2169
Score = 446 bits (1148), Expect = 7e-136, Method: Composition-based stats.
Identities = 116/645 (18%), Positives = 255/645 (40%), Gaps = 77/645 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C R ++ TIF L L FI S + D + + +++ +F
Sbjct 917 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRN---HILFYFDIVFTTIF 973
Query 137 AADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLR 191
++++K +G F +N + + L+V+ VSL+ + + S + + LR+ R+LR
Sbjct 974 TIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLR 1033
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1034 PLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG-KLYTCSDSSK 1092
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
Q E + + + ++ P +N + ++ +M L T
Sbjct 1093 ----QTEAECKGNYITYKDGEVDQPIIQPRSWENSKFDFDNVL------AAMMALFT--- 1139
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ + L S+ T + + V F + + ++ + +
Sbjct 1140 VSTFEGWP-ELLYRSIDS---HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1195
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ +Q E Y + L + Q + L ++ + P+ ++Q ++
Sbjct 1196 VTFQEQGEQE----YKNCELDKNQRQCVEYALKARPLRRYIPKNQHQ----YKVWYVVNS 1247
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
YF+YL ++ L N +IC+ + + + ILN +F + +EM+LK+ A
Sbjct 1248 TYFEYLMFVLILLN--TICLAM---QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1302
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+ Y N FD L+ V +++I+ V H P M + +
Sbjct 1303 KPKHYFCDAWNTFDALIV-VGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR 1361
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
V R ++++ + + + T + Q + ++V++++++A+IG+ +F +
Sbjct 1362 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------- 1414
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR--RYSGPW 669
+ NNF F A++ L+ WQ + A + P
Sbjct 1415 -----------ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1463
Query 670 SK-----------------IYFVLWWLVSSVIWVNLFLALILENF 697
S YF+ ++++ + + +NLF+A++++NF
Sbjct 1464 SDPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVVMDNF 1508
Score = 375 bits (962), Expect = 5e-111, Method: Composition-based stats.
Identities = 123/739 (17%), Positives = 260/739 (35%), Gaps = 133/739 (18%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I+ L I + + + E VE L L++F
Sbjct 142 IRRACISIVEWKPFEIIILLTIFANCVALAIY-IPFPEDDSNATNSNLERVEYLFLIIFT 200
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC------------- 180
+ +K G LF + +N W L +++VV L + +
Sbjct 201 VEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 260
Query 181 -HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + LL+ + ++ + G+ LF
Sbjct 261 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHTALLVLFVIIIYAIIGLELFM 320
Query 240 GGKQDDGQDRERLT---------------------------------------YFQNLPE 260
G ++E +T F N
Sbjct 321 GKMHKTCYNQEGITDVPAEEDPSPCALESGHGRQCQNGTVCKPGWDGPKHGITNFDNFAF 380
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF 315
++ ++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 381 AMLTVFQCITMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 437
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ-LDSS 374
K+ F++ R ++ + G QA + P+N + + + + + S
Sbjct 438 SKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGVDEEKPRNMS 494
Query 375 HKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ E V + G + +L + + +S + R + + +
Sbjct 495 MPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCRRKCRAAVKS 552
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F +L + N ++I L + N + + EMLLK+++L
Sbjct 553 NVFYWLVIFLVFLNTLTIASEHYNQPHWLTE-----VQDTANKALLALFTAEMLLKMYSL 607
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
GL+ Y N D + ++ I + + +++L
Sbjct 608 GLQAYFVSLFNRLDCFIVCGGILETIL------------------VETKIMSPLGISVLR 649
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII---GINLFRGVIVAL 608
R LRI + +++ V L+ ++R+ +L++++ I G+ LF G
Sbjct 650 CVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF--- 706
Query 609 PGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSG 667
+F+++ + FD+F +L+T++ ++ +W V D Y G
Sbjct 707 ----------------NFDEMRTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 750
Query 668 PWS-----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTV 722
P IYF++ ++ + I +N+FLA+ ++N + + L + +
Sbjct 751 PSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNL-------ADAESLTSAQKEEEEEKE 803
Query 723 ELLFRDILEEPGEDELTER 741
+ E+ E+
Sbjct 804 RKKLARTASPEKKQEVVEK 822
Score = 372 bits (954), Expect = 6e-110, Method: Composition-based stats.
Identities = 141/735 (19%), Positives = 278/735 (38%), Gaps = 87/735 (12%)
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFI 99
+ A IE + HR+ S Y R ++ C+R + +L++FL F+
Sbjct 506 ENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 565
Query 100 ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL- 158
T + A Y W ++ L +F A++ +K Y G + +L+
Sbjct 566 NT----LTIASEHYNQPHWLTEVQ--DTANKALLALFTAEMLLKMYSLGLQAYFVSLFNR 619
Query 159 LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
L +V ++ +++ T +S + LR RLLR F + + + + + + S+
Sbjct 620 LDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRS 679
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+AS+ LLL + + +F++ GM LF GGK + + R R + F N P+SL ++ +LT +
Sbjct 680 IASLLLLLFLFIIIFSLLGMQLF-GGKFNFDEMRTRRSTFDNFPQSLLTVFQILTGEDWN 738
Query 276 DVMIPAYSK-------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF---------RGYL 319
VM I+FI+ + G+ L+N+ AI +
Sbjct 739 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 798
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLD 372
+ + R EV+ E + A G P + +Q +
Sbjct 799 EEEKERKKLARTASPEKKQEVVEKPAVEETKEEKIELKSITADGESPPTTKINMDDLQPN 858
Query 373 SSHKQAMMEKVRSYG-----SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ ++ + G + + +EL + P PE + F+ S
Sbjct 859 ENEDKSPYPNPDAAGEEDEEEPEMPVGPRPRPLSELHLKE--KAVPMPEASAFFIFSPNN 916
Query 428 LFGHYYFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
F + + + L ++ + L + V + IL + VF + +E
Sbjct 917 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIE 976
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ LK+ A G +L S + + LLV+ +S ++ S ++
Sbjct 977 IALKMTAYG--AFLHKGSFCRNYFNILDLLVVSVSLISFGIQS------------SAINV 1022
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 1023 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG 1082
Query 604 VIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMV 651
+ +S A +++ Q W N +FD+ AA++ L+ +
Sbjct 1083 KLYTCSDSSKQTEAECKGNYITYKDGEVDQPIIQPRSWENSKFDFDNVLAAMMALFTVST 1142
Query 652 VNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKW 701
W L D++ GP +++ ++ + +N+F+ ++ F +
Sbjct 1143 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1202
Query 702 DPRSHLQPLAGTPEA 716
+ L
Sbjct 1203 EQEYKNCELDKNQRQ 1217
Score = 207 bits (526), Expect = 2e-54, Method: Composition-based stats.
Identities = 72/383 (19%), Positives = 144/383 (38%), Gaps = 47/383 (12%)
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QSPFLQ 423
+D+ + +M + +S+ + ++ + RP ++P +
Sbjct 85 IDAGRQAKLMGSAGNTTISTVSSTQRKRQQYGKPKKQSGTTATRPPRALLCLTLKNPIRR 144
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F+ + L AN V++ +++ D A + L + +F++ + +E
Sbjct 145 ACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA--TNSNLERVEYLFLIIFTVE 202
Query 484 MLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
LKV A G YL N+ D ++ VV L I A + G
Sbjct 203 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD- 261
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L V R LR++ + + VV ++++ + + +++ V ++AIIG+
Sbjct 262 ----VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHTALLVLFVIIIYAIIGLE 317
Query 600 LFRGVIVALPGNSS---------------------LAPANGSAPCGSFEQLEYWANNFDD 638
LF G + N NG+ ++ ++ NFD+
Sbjct 318 LFMGKMHKTCYNQEGITDVPAEEDPSPCALESGHGRQCQNGTVCKPGWDGPKHGITNFDN 377
Query 639 FAAALVTLWNLMVVNNWQV---FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
FA A++T++ + + W ++ Y PW +YFV + S +NL L ++
Sbjct 378 FAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVLGVLSG 435
Query 696 NF---LHKWDPRSHLQPLAGTPE 715
F K R Q L +
Sbjct 436 EFSKEREKAKARGDFQKLREKQQ 458
>sp|Q01668|CAC1D_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Homo sapiens OX=9606 GN=CACNA1D PE=1 SV=2
Length=2161
Score = 445 bits (1145), Expect = 2e-135, Method: Composition-based stats.
Identities = 116/641 (18%), Positives = 245/641 (38%), Gaps = 77/641 (12%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 879 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILG---YFDYAFTAIFTVEIL 935
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 936 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 995
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 996 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYRCTDEAKSN--- 1051
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F F + S +M L T S F
Sbjct 1052 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDF-NFDNVLSA-MMALFT---VSTFE 1101
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
G+ L ++ + + V F + + ++ + + + +
Sbjct 1102 GWPA-LLYKAIDS---NGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1157
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P+ ++ F+Y
Sbjct 1158 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIP----KNPYQYKFWYVVNSSPFEY 1209
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + ++ + + ILN VF + +EM+LKV A +GY
Sbjct 1210 MMFVLIMLNTLCLAM-----QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1264
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM---TRMLNMLIVF 553
S N FD L+ + ++ + A P S + V
Sbjct 1265 FSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVM 1324
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R ++++ + + + T + Q + ++ ++++++A+IG+ +F V + +
Sbjct 1325 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQIN 1384
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY--RRYSGPWSK 671
F F A++ L+ WQ + A + P S
Sbjct 1385 RNNN------------------FQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESD 1426
Query 672 ---------------IYFVLWWLVSSVIWVNLFLALILENF 697
+YF+ ++++ + + +NLF+A+I++NF
Sbjct 1427 YNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467
Score = 361 bits (926), Expect = 2e-106, Method: Composition-based stats.
Identities = 130/740 (18%), Positives = 262/740 (35%), Gaps = 125/740 (17%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I L I + + + E VE L++F
Sbjct 115 IRRACISIVEWKPFDIFILLAIFANCVALAIY-IPFPEDDSNSTNHNLEKVEYAFLIIFT 173
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVS---------------LSL 178
+ +K +G + +N W L V+++V L +
Sbjct 174 VETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGG 233
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 234 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Query 239 AGGKQDDG-------------------------------------QDRERLTYFQNLPES 261
G +T F N +
Sbjct 294 IGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFA 353
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYAI-----FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y N A +F+ + GS F++NL+ ++ +F
Sbjct 354 MLTVFQCITMEGWTDVL---YWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS 410
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA + P+N + ++ + ++S
Sbjct 411 KEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMP 467
Query 377 QAMMEKVRSYGSVLLSAE-EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFL--FGHYY 433
+ E V + +S E E + L +++ K R + +
Sbjct 468 TSETESVNTEN---VSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT 524
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F +L ++ N ++I D L I I N V + + EML+K+++LGL
Sbjct 525 FYWLVIVLVFLNTLTISSEHYNQPDWL-----TQIQDIANKVLLALFTCEMLVKMYSLGL 579
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+ Y N FD + + I P +++
Sbjct 580 QAYFVSLFNRFDCFVVCGGITETILVELEIMSPL------------------GISVFRCV 621
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPG 610
R LRI + +++ V L+ +M+ + +L + +F+++G+ LF G
Sbjct 622 RLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF----- 676
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPW 669
+F++ + + FD+F AL+T++ ++ +W V D Y GP
Sbjct 677 --------------NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPS 722
Query 670 SK-----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
S IYF++ ++ + I +N+FLA+ ++N + + A E E
Sbjct 723 SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKES 782
Query 725 LFRDILEEPGEDELTERLSQ 744
L +P +++ ++
Sbjct 783 LENKKNNKPEVNQIANSDNK 802
Score = 295 bits (755), Expect = 8e-84, Method: Composition-based stats.
Identities = 126/716 (18%), Positives = 251/716 (35%), Gaps = 94/716 (13%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW 149
+L++ L F+ T + + Y W + L +F ++ VK Y G
Sbjct 526 YWLVIVLVFLNT----LTISSEHYNQPDWLTQIQDI--ANKVLLALFTCEMLVKMYSLGL 579
Query 150 AHFQKNLWL-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
+ +L+ VV + +++ +S + R RLLR F + ++ + +
Sbjct 580 QAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNL 639
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSL 265
+ + S+ +AS+ LLL + + +F++ GM LF GGK + + + + + F N P++L ++
Sbjct 640 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDETQTKRSTFDNFPQALLTV 698
Query 266 LVLLTTANNPDVMIPAY-------SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
+LT + VM S I+FI+ + G+ L+N+ AI
Sbjct 699 FQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD- 757
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
+SL T+ E E + + + KV +D ++
Sbjct 758 -AESLNTAQKEEAEEK----ERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREED 812
Query 379 MME--------------KVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------EYQ 418
+ + + A + +EL+ P
Sbjct 813 EDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 872
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P L H+ F L + + + L + + + ILG + F
Sbjct 873 NPIRVGCHKLINHHIFTNLILVFIMLS----SAALAAEDPIRSHSFRNTILGYFDYAFTA 928
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ +E+LLK+ G + N+ D L+ V LV
Sbjct 929 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLV------------------SF 970
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + ++L +L V R LR I K + V V ++ + + ++ ++FA
Sbjct 971 GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1030
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ------------LEYWANNFDDFAAA 642
IG+ LF+G + P ++ + NFD+ +A
Sbjct 1031 CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSA 1090
Query 643 LVTLWNLMVVNNWQVFLD-AYRRYSGPWSKIY---------FVLWWLVSSVIWVNLFLAL 692
++ L+ + W L A IY F+++ ++ + +N+F+
Sbjct 1091 MMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGF 1150
Query 693 ILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDILEEPGEDELTERLSQHP 746
++ F + + L Y + L R I + P + + ++ P
Sbjct 1151 VIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSP 1206
>sp|P27732|CAC1D_RAT Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Rattus norvegicus OX=10116 GN=Cacna1d PE=1
SV=2
Length=2203
Score = 442 bits (1137), Expect = 3e-134, Method: Composition-based stats.
Identities = 114/638 (18%), Positives = 242/638 (38%), Gaps = 86/638 (13%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 938 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILG---YFDYAFTAIFTVEIL 994
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 995 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1054
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1055 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYRCTDEAKSN--- 1110
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F F + S +M L T S F
Sbjct 1111 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDF-NFDNVLSA-MMALFT---VSTFE 1160
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
G+ L ++ V + V F + + ++ + + + +
Sbjct 1161 GWPA-LLYKAIDS---NGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1216
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P+ ++ F+Y
Sbjct 1217 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIP----KNPYQYKFWYVVNSSPFEY 1268
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + ++ + + ILN VF + +EM+LKV A +GY
Sbjct 1269 MMFVLIMLNTLCLAM-----QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1323
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
S N FD L+ + ++ S + V R +
Sbjct 1324 FSDAWNTFDSLIVIGSII------------DVALSEADNSEESNRISITFFRLFRVMRLV 1371
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
+++ + + + T + Q + ++ ++++++A+IG+ +F V + +
Sbjct 1372 KLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN 1431
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DAYRRY-- 665
F F A++ L+ WQ + D Y
Sbjct 1432 N------------------FQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNP 1473
Query 666 ------SGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1474 GEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1511
Score = 337 bits (864), Expect = 3e-98, Method: Composition-based stats.
Identities = 128/793 (16%), Positives = 267/793 (34%), Gaps = 172/793 (22%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I L I + + + E VE L++F
Sbjct 115 IRRACISIVDWKPFDIFILLAIFANCVALAIY-IPFPEDDSNSTNHNLEKVEYAFLIIFT 173
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------------LSL 178
+ +K G L +N W L V+++V L +
Sbjct 174 VETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGG 233
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 234 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Query 239 AGGKQDDG-------------------------------------QDRERLTYFQNLPES 261
G +T F N +
Sbjct 294 IGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFA 353
Query 262 LTSLLVLLTTANNPDVMIPAYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y N ++F+ ++GS F++NL+ ++ +F
Sbjct 354 MLTVFQCITMEGWTDVL---YWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS 410
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA + P+N + ++ + ++S
Sbjct 411 KEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMP 467
Query 377 QAMMEKVRSY----------------------GSVLLSAEEFQKLFNELDRSVVKEHPPR 414
+ E V + G+ ++ + +S ++ H R
Sbjct 468 TSETESVNTENVSGEGETQGCCGSLWCWWKRRGAAKTGPSGCRRWGQAISKSKLRSHGAR 527
Query 415 --------------PEYQSPFLQSAQFLFGHYY-----------------------FDYL 437
+ S F Q + Y F +L
Sbjct 528 EALCVCRCSLESLVKLWTSRFSAHLQAAYVRPYSRRWRRWNRFNRRRCRAAVKSVTFYWL 587
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
++ N ++I D L I I N V + + EML+K+++LGL+ Y
Sbjct 588 VIVLVFLNTLTISSEHYNQPDWL-----TQIQDIANKVLLALFTCEMLVKMYSLGLQAYF 642
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N FD + + I + P V + + + R +
Sbjct 643 VSLFNRFDCFVVCGGITETIL------VELELMSPLGVSV---------FRCVRLLRIFK 687
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+ ++ + +++L ++++ + +L + +F+++G+ LF G
Sbjct 688 VTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF------------ 735
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWSK----- 671
+F++ + + FD+F AL+T++ ++ +W V D Y GP S
Sbjct 736 -------NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVC 788
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
IYF++ ++ + I + LFLA+ ++N + + A E E L
Sbjct 789 IYFIILFICGNYILLKLFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNN 848
Query 732 EPGEDELTERLSQ 744
+P +++ ++
Sbjct 849 KPEVNQIANSDNK 861
Score = 293 bits (751), Expect = 3e-83, Method: Composition-based stats.
Identities = 126/716 (18%), Positives = 251/716 (35%), Gaps = 94/716 (13%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW 149
+L++ L F+ T + + Y W + L +F ++ VK Y G
Sbjct 585 YWLVIVLVFLNT----LTISSEHYNQPDWLTQIQDI--ANKVLLALFTCEMLVKMYSLGL 638
Query 150 AHFQKNLWL-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
+ +L+ VV + +++ +S + R RLLR F + ++ + +
Sbjct 639 QAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNL 698
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSL 265
+ + S+ +AS+ LLL + + +F++ GM LF GGK + + + + + F N P++L ++
Sbjct 699 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDETQTKRSTFDNFPQALLTV 757
Query 266 LVLLTTANNPDVMIPAY-------SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
+LT + VM S I+FI+ + G+ L+ L AI
Sbjct 758 FQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLKLFLAIAVDNLAD- 816
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
+SL T+ E E + + + KV +D ++A
Sbjct 817 -AESLNTAQKEEAEEK----ERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEA 871
Query 379 MME--------------KVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------EYQ 418
+ + + A + +EL+ P
Sbjct 872 EDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKT 931
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P L H+ F L + + + L + + + ILG + F
Sbjct 932 NPIRVGCHKLINHHIFTNLILVFIMLS----SAALAAEDPIRSHSFRNTILGYFDYAFTA 987
Query 479 YYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ +E+LLK+ G + N+ D L+ V LV
Sbjct 988 IFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLV------------------SF 1029
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S + ++L +L V R LR I K + V V ++ + + ++ ++FA
Sbjct 1030 GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA 1089
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ------------LEYWANNFDDFAAA 642
IG+ LF+G + P ++ + NFD+ +A
Sbjct 1090 CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSA 1149
Query 643 LVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLAL 692
++ L+ + W L D+ GP +++ ++ + +N+F+
Sbjct 1150 MMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGF 1209
Query 693 ILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDILEEPGEDELTERLSQHP 746
++ F + + L Y + L R I + P + + ++ P
Sbjct 1210 VIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSP 1265
Score = 204 bits (520), Expect = 2e-53, Method: Composition-based stats.
Identities = 70/383 (18%), Positives = 134/383 (35%), Gaps = 40/383 (10%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QS 419
Q + +A S + S + ++ + RP +
Sbjct 54 QAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNN 113
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++ + FD L AN V++ +++ D + + L + F++
Sbjct 114 PIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNS--TNHNLEKVEYAFLII 171
Query 480 YLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
+ +E LK+ A G + N+ D ++ +V L I
Sbjct 172 FTVETFLKIIASGLLLHPNASVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
G + + L V R LR++ + + VV ++++ + + +++ V ++AI
Sbjct 232 GGFDV----KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAI 287
Query 596 IGINLFRGVIVALP-------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IG+ LF G + GN ANG+ + NF
Sbjct 288 IGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNF 347
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILE 695
D+FA A++T++ + + W L G W +YFV ++ S +NL L ++
Sbjct 348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSG 407
Query 696 NF---LHKWDPRSHLQPLAGTPE 715
F K R Q L +
Sbjct 408 EFSKEREKAKARGDFQKLREKQQ 430
>sp|P22002|CAC1C_RAT Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Rattus norvegicus OX=10116 GN=Cacna1c PE=1
SV=1
Length=2169
Score = 441 bits (1134), Expect = 5e-134, Method: Composition-based stats.
Identities = 119/645 (18%), Positives = 258/645 (40%), Gaps = 78/645 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C R ++ TIF L L FI S + D + + +++ +F
Sbjct 918 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRN---HILFYFDIVFTTIF 974
Query 137 AADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIRRLLR 191
++++K +G F +N + + L+V+ VSL+ + + S + + LR+ R+LR
Sbjct 975 TIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLR 1034
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1035 PLR-INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG-KLYTCSDSSK 1092
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
Q ES + + T + ++ P +N + ++ +M L T
Sbjct 1093 ----QTEAESKGNYITYKTGEVDHPIIQPRSWENSKFDFDNVL------AAMMALFT--- 1139
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ + L S+ T + + V F + + ++ + +
Sbjct 1140 VSTFEGWP-ELLYRSIDS---HTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVI 1195
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ +Q E Y + L + Q + L + + P+ ++Q ++
Sbjct 1196 VTFQEQGEQE----YKNCELDKNQRQCVEYALKARPLPRYIPKNQHQ----YKVWYVVNS 1247
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
YF+YL ++ L N +IC+ + + + ILN +F + +EM+LK+ A
Sbjct 1248 TYFEYLMFVLILLN--TICLAM---QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1302
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+ Y N FD L+ V +++I+ V+ H P M + +
Sbjct 1303 KPKHYFCDAWNTFDALIV-VGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFR 1361
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
V R ++++ + + + T + Q + ++V++++++A+IG+ +F +
Sbjct 1362 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------- 1414
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR--RYSGPW 669
+ NNF F A++ L+ WQ + A + P
Sbjct 1415 -----------ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPE 1463
Query 670 SK-----------------IYFVLWWLVSSVIWVNLFLALILENF 697
S+ YF+ ++++ + + +NLF+A+I++NF
Sbjct 1464 SEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1508
Score = 367 bits (942), Expect = 2e-108, Method: Composition-based stats.
Identities = 121/736 (16%), Positives = 262/736 (36%), Gaps = 127/736 (17%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I+ L I + + + E VE L L++F
Sbjct 143 IRRACISIVEWKPFEIIILLTIFANCVALAIY-IPFPEDDSNATNSNLERVEYLFLIIFT 201
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC------------- 180
+ +K G LF + +N W L +++VV L + +
Sbjct 202 VEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 261
Query 181 -HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 262 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 321
Query 240 GGKQDDGQDRE---------------------------------------RLTYFQNLPE 260
G ++E +T F N
Sbjct 322 GKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAF 381
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQF 315
++ ++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 382 AMLTVFQCITMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 438
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL-QKVQLDSS 374
K+ F++ R ++ + G QA + P+N + + + + S
Sbjct 439 SKEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMS 495
Query 375 HKQAMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ E V + G + +L + + +S + R + + +
Sbjct 496 MPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCRRKCRAAVKS 553
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F +L + N ++I L + N + + EMLLK+++L
Sbjct 554 NVFYWLVIFLVFLNTLTIASEHYNQPHWLTE-----VQDTANKALLALFTAEMLLKMYSL 608
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
GL+ Y N FD + ++ I + P + +
Sbjct 609 GLQAYFVSLFNRFDCFIVCGGILETIL------VETKIMSPLGISC---------WRCVR 653
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
+ R +I ++ + +++L ++++ + +L + +F+++G+ LF G
Sbjct 654 LLRIFKITRYWNSLSNLVASLLNSLRSIASLLLLLFLFIIIFSLLGMQLFGGKF------ 707
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWS 670
+F++++ + FD+F +L+T++ ++ +W V D Y GP
Sbjct 708 -------------NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSF 754
Query 671 -----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
IYF++ ++ + I +NLFLA+ ++N + + L + +
Sbjct 755 PGMLVCIYFIILFISPNYILLNLFLAIAVDNL-------ADAESLTSAQKEEEEEKERKK 807
Query 726 FRDILEEPGEDELTER 741
+ E+ E+
Sbjct 808 LARTASPEKKQEVMEK 823
Score = 347 bits (890), Expect = 2e-101, Method: Composition-based stats.
Identities = 139/735 (19%), Positives = 274/735 (37%), Gaps = 88/735 (12%)
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFI 99
+ A IE + HR+ S Y R ++ C+R + +L++FL F+
Sbjct 507 ENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 566
Query 100 ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL- 158
T + A Y W ++ L +F A++ +K Y G + +L+
Sbjct 567 NT----LTIASEHYNQPHWLTEVQ--DTANKALLALFTAEMLLKMYSLGLQAYFVSLFNR 620
Query 159 LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+V ++ +++ T +S + R RLLR F + + + + + + SL
Sbjct 621 FDCFIVCGGILETILVETKIMSPLGISCWRCVRLLRIFKITRYWNSLSNLVASLLNSLRS 680
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+AS+ LLL + + +F++ GM LF GGK + + + R + F N P+SL ++ +LT +
Sbjct 681 IASLLLLLFLFIIIFSLLGMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 739
Query 276 DVMIPAYSK-------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF---------RGYL 319
VM I+FI+ + + L+NL AI +
Sbjct 740 SVMYDGIMAYGGPSFPGMLVCIYFIILFISPNYILLNLFLAIAVDNLADAESLTSAQKEE 799
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLD 372
+ + R EV+ E + A G P + +Q
Sbjct 800 EEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPS 859
Query 373 SSHKQAMMEKVRSYG-----SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ ++ + G + + +EL + P PE + F+ S
Sbjct 860 ENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKE--KAVPMPEASAFFIFSPNN 917
Query 428 LFGHYYFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
F + + + L ++ + L + V + IL + VF + +E
Sbjct 918 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIE 977
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ LK+ A G +L S + + LLV+ +S ++ S ++
Sbjct 978 IALKMTAYG--AFLHKGSFCRNYFNILDLLVVSVSLISFGIQS------------SAINV 1023
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 1024 VKILRVLRVLRPLR-INRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG 1082
Query 604 VIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN---NFDDFAAALVTLWNLMV 651
+ +S A +++ Q W N +FD+ AA++ L+ +
Sbjct 1083 KLYTCSDSSKQTEAESKGNYITYKTGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVST 1142
Query 652 VNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKW 701
W L D++ GP +++ ++ + +N+F+ ++ F +
Sbjct 1143 FEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQG 1202
Query 702 DPRSHLQPLAGTPEA 716
+ L
Sbjct 1203 EQEYKNCELDKNQRQ 1217
>sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabidopsis
thaliana OX=3702 GN=TPC1 PE=1 SV=1
Length=733
Score = 415 bits (1067), Expect = 2e-133, Method: Composition-based stats.
Identities = 179/763 (23%), Positives = 319/763 (42%), Gaps = 79/763 (10%)
Query 8 SEPLLGGARGGGGDWPAGLTTYRSIQVGPG-----AAARWDLCIDQAVVFIEDAIQYRSI 62
+PL+G GGG RS + G AAA DL D + +E
Sbjct 2 EDPLIGRDSLGGG---GTDRVRRSEAITHGTPFQKAAALVDLAEDGIGLPVE-------- 50
Query 63 NHRVDASSMWLYRRYYSNVCQRTL--SFTIFLILFLAFIETP-----SSLTSTADVRYRA 115
+D SS RYY + L S F +LFL F E P + S D Y
Sbjct 51 --ILDQSSFGESARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYY 108
Query 116 APWEPPCGLTESV--EVLCLLVFAADLSVKGYLFGWAHFQK---NLWLLGYLVVLVVSLV 170
P ES+ EV+ L + G F NL + +V+L V ++
Sbjct 109 LGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVL 168
Query 171 DWTVSLSLVCHE--PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
+ LS + + P RI +R + + ++ TL + L ++ L + L
Sbjct 169 VDFLYLSPLAFDFLPFRIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFLL 228
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
+ ++F ++ LT F + +L + +L TT+NNPDV IPAY +R
Sbjct 229 FASWIAFVMFE-------DTQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWS 281
Query 289 AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEG 348
++FF+++ +IG F+ NL+ A++Y F+ L K + +R AF ++ S
Sbjct 282 SVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGE 341
Query 349 GAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
Q + L ++ + +++ ++ +EF L +
Sbjct 342 IDKNQ-CIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQAIALRFQ 400
Query 409 KEHPPR-----PE-YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
KE P P+ Y S Q + F Y + I + N +++ V LD + A
Sbjct 401 KEEVPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLDIEESSA 460
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
++ + VF Y+LEM LK++ G Y +N FD L+T V+++ E +T
Sbjct 461 QKPWQV---AEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFIT 517
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
P+ S + R L + + R +R++ +++ +T + L+ ++ +
Sbjct 518 ---------PDENTFFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPSLMPY 568
Query 583 GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
G + V ++ IG+ +F G++ A GN L + +Y NF+D+
Sbjct 569 LGTIFCVLCIYCSIGVQVFGGLVNA--GNKKLFETE-------LAEDDYLLFNFNDYPNG 619
Query 643 LVTLWNLMVVNNWQVFLDAYRRYSGPWSKI-YFVLWWLVSSVIWVNLFLALILENFLHKW 701
+VTL+NL+V+ NWQV++++Y+ +G W I YFV +++++ ++ +NL +A +LE F +
Sbjct 620 MVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTEL 679
Query 702 DPRSHLQPLAGTPE-----------ATYQMTVELLFRDILEEP 733
D + + + V+ L +L +
Sbjct 680 DLEEEEKCQGQDSQEKRNRRRSAGSKSRSQRVDTLLHHMLGDE 722
>sp|O60840|CAC1F_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1F OS=Homo sapiens OX=9606 GN=CACNA1F PE=1 SV=2
Length=1977
Score = 434 bits (1115), Expect = 1e-131, Method: Composition-based stats.
Identities = 116/638 (18%), Positives = 242/638 (38%), Gaps = 79/638 (12%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + +F L L FI S + D + G + +F ++
Sbjct 864 CHTLIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILG---YFDYAFTSIFTVEIL 920
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K +FG F ++ + + L+V+ VSL+ + + S + + LR+ R+LRP +
Sbjct 921 LKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAI 980
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D + T
Sbjct 981 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYTCTDEAKHT--- 1036
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
P+ ++ DV P + F F + S +M L T + +
Sbjct 1037 --PQECKGSFLVYPDG---DVSRPLVRERLWVNSDF-NFDNVLSA-MMALFTVSTFEGWP 1089
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
L K++ + + V F + + ++ + + +
Sbjct 1090 ALLYKAIDA-------YAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRA 1142
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P F+Y
Sbjct 1143 QGEQE----YQNCELDKNQRQCVEYALKAQPLRRYIP----KNPHQYRVWATVNSAAFEY 1194
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
L L+ L N V++ + ++ + ILN VF + +EM+LK+ A + Y
Sbjct 1195 LMFLLILLNTVALAM-----QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHY 1249
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
+ N FD L+ V +++I+ V H G E +S + V R +
Sbjct 1250 FTDAWNTFDALIV-VGSIVDIAVTEVNNGGHLGESSEDSSRIS----ITFFRLFRVMRLV 1304
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
+++ + + + T + Q + ++ ++++++A+IG+ +F V + +
Sbjct 1305 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQIN--- 1361
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY--RRYSGPWSKI-- 672
NNF F A++ L+ WQ + A P S
Sbjct 1362 ---------------RNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGP 1406
Query 673 -------------YFVLWWLVSSVIWVNLFLALILENF 697
YF+ ++++ + + +NLF+A+I++NF
Sbjct 1407 GEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNF 1444
Score = 321 bits (823), Expect = 8e-93, Method: Composition-based stats.
Identities = 119/729 (16%), Positives = 243/729 (33%), Gaps = 157/729 (22%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C + + F IL L I + + + + E VE + L++F
Sbjct 82 RRSCISIVEWKPFDILILLTI-FANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFTV 140
Query 139 DLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--------------- 179
+ +K +G + + +N W L +++VV L +
Sbjct 141 ETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGF 200
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ + L I +L + + LL+ + ++ + G+ LF
Sbjct 201 DVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 260
Query 240 GGKQDDGQ-------------------------------------DRERLTYFQNLPESL 262
G +T F N ++
Sbjct 261 GRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAM 320
Query 263 TSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 321 LTVFQCVTMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSK 377
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA-----VGVKPQNLLQVLQKVQLD 372
K+ F+++ R ++ + G QA + L + +
Sbjct 378 EREKAKARGDFQKQ---REKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRA 434
Query 373 SSHKQAMMEKVRSYG--------------------------------SVLLSAEEFQ--- 397
Q R G EE
Sbjct 435 GHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEEEGALAS 494
Query 398 --KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
+ N++ ++ V R + + L+ N ++I
Sbjct 495 CTRCLNKIMKTRVCRRLRRA--NRVLRARCRRAVKSNACYWAVLLLVFLNTLTIA----- 547
Query 456 DADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVL 515
I N V + + +EMLLK++ LG Y+S N FD + +L
Sbjct 548 SEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGG-IL 606
Query 516 EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
E + + V + G +L + + R ++ ++ + +++L
Sbjct 607 ETTLVEVGAMQPLGIS--------------VLRCVRLLRIFKVTRHWASLSNLVASLLNS 652
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
++++ + +L + +F+++G+ LF G +F+Q +
Sbjct 653 MKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------------------NFDQTHTKRST 693
Query 636 FDDFAAALVTLWNLMVVNNWQVFL-DAYRRYSGPWS-----KIYFVLWWLVSSVIWVNLF 689
FD F AL+T++ ++ +W V + D Y GP+ IYF++ ++ + I +N+F
Sbjct 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 753
Query 690 LALILENFL 698
LA+ ++N
Sbjct 754 LAIAVDNLA 762
Score = 304 bits (779), Expect = 4e-87, Method: Composition-based stats.
Identities = 125/717 (17%), Positives = 259/717 (36%), Gaps = 81/717 (11%)
Query 64 HRVDASSMWLYRRYYSNV----CQRTL--SFTIFLILFLAFIETPSSLTSTADVRYRAAP 117
+++ + + R + V C+R + + + +L L F+ T + A +
Sbjct 500 NKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNT----LTIASEHHGQPV 555
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLVVSL---VDWT 173
W + E + L +F ++ +K Y G + + + + VV L +
Sbjct 556 WLT--QIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEV 613
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
++ + LR RLLR F + ++ + + + + S+ +AS+ LLL + + +F++
Sbjct 614 GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 673
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-------NR 286
GM LF GGK + Q + + F P++L ++ +LT + VM
Sbjct 674 GMQLF-GGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGM 732
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
I+FI+ + G+ L+N+ AI + + +
Sbjct 733 LVCIYFIILFICGNYILLNVFLAIAVDNLASG--DAGTAKDKGGEKSNEKDLPQENEGLV 790
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
G + + +++ + + ++ E+ + G LL ++ +
Sbjct 791 PG--VEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEG 848
Query 407 VVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD 466
+ +P + L H+ F L + + + VS L + + +
Sbjct 849 SAFFCLSQ---TNPLRKGCHTLIHHHVFTNLILVFIILSSVS----LAAEDPIRAHSFRN 901
Query 467 FILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPS-NVFDGLLTVVLLVLEISTLAV 522
ILG + F + +E+LLK+ G RG N+ D L+ V L+
Sbjct 902 HILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLI-------- 953
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
S + ++L +L V R LR I K + V V ++ +
Sbjct 954 ----------SFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1003
Query 583 GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWA--------- 633
+ ++ ++FA IG+ LF+G + P + +
Sbjct 1004 MIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWV 1063
Query 634 ---NNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYF------VLWWLV 680
NFD+ +A++ L+ + W L DAY GP +++ ++
Sbjct 1064 NSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIII 1123
Query 681 SSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDILEEPGE 735
+ +N+F+ ++ F + + L Y + + L R I + P +
Sbjct 1124 IAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQ 1180
Score = 198 bits (504), Expect = 1e-51, Method: Composition-based stats.
Identities = 72/332 (22%), Positives = 131/332 (39%), Gaps = 37/332 (11%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P +S + FD L L AN V++ V++ D + + L + VF+V
Sbjct 79 NPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDD--SNTANHNLEQVEYVFLV 136
Query 479 YYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ +E +LK+ A G Y+ N+ D ++ VV L S L PG P
Sbjct 137 IFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL---FSVLLEQGPGRPGDAPHT 193
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
G +D+ + L V R LR++ + + +V ++++ + + +++ V ++A
Sbjct 194 GGKPGGFDV-KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYA 252
Query 595 IIGINLFRGVI-------------------VALPGNSSLAPANGSAPCGSFEQLEYWANN 635
IIG+ LF G + A G+ N + G + N
Sbjct 253 IIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITN 312
Query 636 FDDFAAALVTLWNLMVVNNWQV---FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLAL 692
FD+F A++T++ + + W ++ Y PW +YFV + S +NL L +
Sbjct 313 FDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVLGV 370
Query 693 ILENF---LHKWDPRSHLQPLAGTPEATYQMT 721
+ F K R Q + +
Sbjct 371 LSGEFSKEREKAKARGDFQKQREKQQMEEDLR 402
>sp|Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1C OS=Homo sapiens OX=9606 GN=CACNA1C PE=1 SV=4
Length=2221
Score = 434 bits (1117), Expect = 1e-131, Method: Composition-based stats.
Identities = 121/689 (18%), Positives = 260/689 (38%), Gaps = 117/689 (17%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC-------------- 122
+ C R ++ TIF L L FI S + D +
Sbjct 888 RFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIE 947
Query 123 ---GLTESVEVLCLLVFAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVS 175
+ + + + +F ++ +K +G F +N + + L+V+ VSL+ + +
Sbjct 948 IALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQ 1007
Query 176 LSLV-CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
S + + LR+ R+LRP + + +K ++C+ ++ + ++ ++ + +F G
Sbjct 1008 SSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIG 1067
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
+ LF G K D + Q E + + + ++ P +N + ++
Sbjct 1068 VQLFKG-KLYTCSDSSK----QTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVL 1122
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
+M L T S F G+ + L S+ T + + V F
Sbjct 1123 ------AAMMALFT---VSTFEGWP-ELLYRSIDS---HTEDKGPIYNYRVEISIFFIIY 1169
Query 355 VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR 414
+ + ++ + + + +Q E Y + L + Q + L ++ + P+
Sbjct 1170 IIIIAFFMMNIFVGFVIVTFQEQGEQE----YKNCELDKNQRQCVEYALKARPLRRYIPK 1225
Query 415 PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC 474
++Q ++ YF+YL ++ L N +IC+ + + + ILN
Sbjct 1226 NQHQ----YKVWYVVNSTYFEYLMFVLILLN--TICLAM---QHYGQSCLFKIAMNILNM 1276
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTV------------------------ 510
+F + +EM+LK+ A +GY S P NVFD L+ +
Sbjct 1277 LFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDA 1336
Query 511 ---VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
V +++I+ V H P M + + V R ++++ + +
Sbjct 1337 LIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRT 1396
Query 568 VASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
+ T + Q + ++V++++++A+IG+ +F + +
Sbjct 1397 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------------------ALNDT 1438
Query 628 QLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR--RYSGPWSK-------------- 671
NNF F A++ L+ WQ + A + P S+
Sbjct 1439 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSS 1498
Query 672 ---IYFVLWWLVSSVIWVNLFLALILENF 697
YF+ ++++ + + +NLF+A+I++NF
Sbjct 1499 FAVFYFISFYMLCAFLIINLFVAVIMDNF 1527
Score = 379 bits (973), Expect = 2e-112, Method: Composition-based stats.
Identities = 125/736 (17%), Positives = 263/736 (36%), Gaps = 127/736 (17%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I+ L I + + + E VE L L++F
Sbjct 113 IRRACISIVEWKPFEIIILLTIFANCVALAIY-IPFPEDDSNATNSNLERVEYLFLIIFT 171
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC------------- 180
+ +K G LF + +N W L +++VV L + +
Sbjct 172 VEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGF 231
Query 181 -HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 232 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFM 291
Query 240 GGKQDDGQDRERL---------------------------------------TYFQNLPE 260
G ++E + T F N
Sbjct 292 GKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAF 351
Query 261 SLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
++ ++ +T DV+ I+F+ +IGS F++NL+ ++ +F
Sbjct 352 AMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ-LDSSHKQ 377
K+ F++ R ++ + G QA + P+N + + + + + S
Sbjct 412 REKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPT 468
Query 378 AMMEKVRSY---GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYF 434
+ E V + G + +L + + +S + R + + + F
Sbjct 469 SETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR--WNRFCRRKCRAAVKSNVF 526
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
+L + N ++I + L + N + + EMLLK+++LGL+
Sbjct 527 YWLVIFLVFLNTLTIASEHYNQPNWLTE-----VQDTANKALLALFTAEMLLKMYSLGLQ 581
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y N FD + ++ I + + +++L R
Sbjct 582 AYFVSLFNRFDCFVVCGGILETIL------------------VETKIMSPLGISVLRCVR 623
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII---GINLFRGVIVALPGN 611
LRI + +++ V L+ ++R+ +L++++ I G+ LF G
Sbjct 624 LLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF------ 677
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWS 670
+F++++ + FD+F +L+T++ ++ +W V D Y GP
Sbjct 678 -------------NFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSF 724
Query 671 -----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
IYF++ ++ + I +N+FLA+ ++N + + L + +
Sbjct 725 PGMLVCIYFIILFICGNYILLNVFLAIAVDNL-------ADAESLTSAQKEEEEEKERKK 777
Query 726 FRDILEEPGEDELTER 741
+ EL E+
Sbjct 778 LARTASPEKKQELVEK 793
Score = 349 bits (894), Expect = 4e-102, Method: Composition-based stats.
Identities = 137/753 (18%), Positives = 270/753 (36%), Gaps = 103/753 (14%)
Query 46 IDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFI 99
+ A IE + HR+ S Y R ++ C+R + +L++FL F+
Sbjct 477 ENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL 536
Query 100 ETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL- 158
T + A Y W ++ L +F A++ +K Y G + +L+
Sbjct 537 NT----LTIASEHYNQPNWLTEVQ--DTANKALLALFTAEMLLKMYSLGLQAYFVSLFNR 590
Query 159 LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
VV ++ +++ T +S + LR RLLR F + + + + + + S+
Sbjct 591 FDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRS 650
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+AS+ LLL + + +F++ GM LF GGK + + + R + F N P+SL ++ +LT +
Sbjct 651 IASLLLLLFLFIIIFSLLGMQLF-GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWN 709
Query 276 DVMIPAYSK-------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF---------RGYL 319
VM I+FI+ + G+ L+N+ AI +
Sbjct 710 SVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE 769
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-------AVGVKPQNLLQVLQKVQLD 372
+ + R E++ + A G P + +Q +
Sbjct 770 EEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPN 829
Query 373 SSHKQAMMEK-----VRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY------QSPF 421
+ ++ + + +EL P + F
Sbjct 830 ENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRF 889
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD----------------ADVLPAERD 465
+ F L L + +S+ + + E
Sbjct 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIA 949
Query 466 DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
ILG + VF + LE++LK+ A G +L S + + LLV+ +S ++
Sbjct 950 LKILGNADYVFTSIFTLEIILKMTAYG--AFLHKGSFCRNYFNILDLLVVSVSLISFGIQ 1007
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
S ++ ++L +L V R LR I K + V V ++ + +
Sbjct 1008 S------------SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIV 1055
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWAN-- 634
++ ++FA IG+ LF+G + +S A +++ Q W N
Sbjct 1056 TTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSK 1115
Query 635 -NFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYF------VLWWLVSSV 683
+FD+ AA++ L+ + W L D++ GP +++ ++ +
Sbjct 1116 FDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAF 1175
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
+N+F+ ++ F + + L
Sbjct 1176 FMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQ 1208
Score = 212 bits (539), Expect = 6e-56, Method: Composition-based stats.
Identities = 73/381 (19%), Positives = 144/381 (38%), Gaps = 43/381 (11%)
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QSPFLQ 423
+D++ + +M + +S+ + ++ + RP ++P +
Sbjct 56 IDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRR 115
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F+ + L AN V++ +++ D A + L + +F++ + +E
Sbjct 116 ACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA--TNSNLERVEYLFLIIFTVE 173
Query 484 MLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
LKV A G YL N+ D ++ VV L I A + G
Sbjct 174 AFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD- 232
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ L V R LR++ + + VV ++++ + + +++ V ++AIIG+
Sbjct 233 ----VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 288
Query 600 LFRGVIVALPGNSS---------------------LAPANGSAPCGSFEQLEYWANNFDD 638
LF G + N NG+ ++ ++ NFD+
Sbjct 289 LFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDN 348
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF 697
FA A++T++ + + W L G W IYFV ++ S +NL L ++ F
Sbjct 349 FAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEF 408
Query 698 ---LHKWDPRSHLQPLAGTPE 715
K R Q L +
Sbjct 409 SKEREKAKARGDFQKLREKQQ 429
>sp|O73700|CAC1D_CHICK Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Gallus gallus OX=9031 GN=CACNA1D PE=2
SV=1
Length=2190
Score = 434 bits (1115), Expect = 2e-131, Method: Composition-based stats.
Identities = 116/649 (18%), Positives = 247/649 (38%), Gaps = 85/649 (13%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C R ++ IF L L FI S + D + G + + +F ++
Sbjct 900 CHRLINHHIFTNLILVFIMLSSVSLAAEDPIRSHSFRNNILG---YADYVFTSMFTFEII 956
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L L+V+ VSLV + + S + + LR+ R+LRP +
Sbjct 957 LKMTAFGAFLHKGSFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1016
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 1017 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYKCTDEAKQN--- 1072
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE + ++ DV P + F F + S +M L T S F
Sbjct 1073 --PEECRGIYIVYKDG---DVDNPMVKERVWQNSDF-NFDNVLSA-MMALFT---VSTFE 1122
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
G+ L ++ V + V F + + ++ + + + +
Sbjct 1123 GWPA-LLYKAIDS---NGENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQE 1178
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P+ ++ F+Y
Sbjct 1179 QGEQE----YKNCELDKNQRQCVEYALKARPLRRYIP----KNPYQYKFWYVVNSTGFEY 1230
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR-- 494
+ ++ + N + + + ++ + + I+N VF + +EM+LK+ A +
Sbjct 1231 IMFVLIMLNTLCLAM-----QHYGQSKLFNDAMDIMNMVFTGVFTVEMVLKLIAFKPKIF 1285
Query 495 --------GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM-TR 545
GY S N FD L+ + +V + + A + E +
Sbjct 1286 VRKKERWLGYFSDAWNTFDSLIVIGSIVDVVLSEADPKPTETVTTDESGNSEDSARISIT 1345
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+ V R ++++ + + + T + Q + ++ ++++++A+IG+ +F V
Sbjct 1346 FFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKVA 1405
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY--R 663
+ + F F A++ L+ WQ + A
Sbjct 1406 MRDNNQINRNNN------------------FQTFPQAVLLLFRCATGEAWQEIMLACLPG 1447
Query 664 RYSGPWSK---------------IYFVLWWLVSSVIWVNLFLALILENF 697
+ P S IYF+ ++++ + + +NLF+A+I++NF
Sbjct 1448 KRCDPESDYNPGEEYTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNF 1496
Score = 357 bits (916), Expect = 6e-105, Method: Composition-based stats.
Identities = 135/766 (18%), Positives = 264/766 (34%), Gaps = 151/766 (20%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I L I + + + + E VE L++F
Sbjct 110 IRRACISLVEWKPFDIFILLSI-FANCVALAVYIPFPEDDSNSTNHNLEKVEYAFLIIFT 168
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSL---------------SL 178
+ +K +G + +N W L V++VV L +
Sbjct 169 VETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKPGG 228
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 229 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 288
Query 239 AGGKQDDG-------------------------------------QDRERLTYFQNLPES 261
G +T F N +
Sbjct 289 IGKMHKSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGGITNFDNFAFA 348
Query 262 LTSLLVLLTTANNPDVMIPAYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y N I+F+ ++GS F++NL+ ++ +F
Sbjct 349 MLTVFQCITMEGWTDVL---YWVNDAIGCEWPWIYFVSLIILGSFFVLNLVLGVLSGEFS 405
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA + P+N + ++ + +
Sbjct 406 KEREKAKARGDFQK---LREKQQLEEDLKGYLDWITQAEDIDPENDEEADEEGKRNRVTL 462
Query 377 QAMMEKVRSY-----------------------GSVLLSAE-EFQKLFNELDRSVVKEHP 412
+ME+ + + +S E E L +++ K
Sbjct 463 ADLMEEKKKSRLSCFGRSSNKHASMPTSETESVNTENVSGEGENPACCGSLCQTISKSKF 522
Query 413 PRPEYQSPFLQ--SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILG 470
R + + F +L ++ N ++I D L I
Sbjct 523 SRRWRRWNRFNRRKCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWL-----TQIQD 577
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
I N V + + EML+K+++LGL+ Y N FD + +V I P
Sbjct 578 IANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEIMSPL--- 634
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
+++ R LRI + A +++ V L+ +M++ +L++++
Sbjct 635 ---------------GISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLF 679
Query 591 YVFAII---GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
I G+ LF G +F++ + + FD+F AL+T++
Sbjct 680 LFIIIFSLLGMQLFGGKF-------------------NFDETQTKRSTFDNFPQALLTVF 720
Query 648 NLMVVNNWQ-VFLDAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHKW 701
++ +W V D Y GP S IYF++ ++ + I +N+FLA+ ++N
Sbjct 721 QILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAE 780
Query 702 DPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPH 747
+ + A E E L E + E +E + P
Sbjct 781 SLNTAQKEEAEEKERKKNARKESL------ENKKSEKSEGDQKKPK 820
Score = 303 bits (776), Expect = 1e-86, Method: Composition-based stats.
Identities = 131/739 (18%), Positives = 261/739 (35%), Gaps = 88/739 (12%)
Query 54 EDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLAFIETPSSLTS 107
E+ S+ + S R ++ +R + +L++ L F+ T +
Sbjct 505 ENPACCGSLCQTISKSKFSRRWRRWNRFNRRKCRAAVKSVTFYWLVIVLVFLNT----LT 560
Query 108 TADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVV-- 164
+ Y W + L +F ++ VK Y G + +L+ VV
Sbjct 561 ISSEHYNQPDWLTQIQDI--ANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCG 618
Query 165 -LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
+V +++ +S + R RLLR F + ++ + + + + S+ +AS+ LLL
Sbjct 619 GIVETILVELEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLL 678
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY- 282
+ + +F++ GM LF GGK + + + + + F N P++L ++ +LT + VM
Sbjct 679 FLFIIIFSLLGMQLF-GGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 737
Query 283 ------SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF--RGYLMKSLQTSLFRRRLGT 334
S I+FI+ + G+ L+N+ AI L + + +
Sbjct 738 AYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKK 797
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM------MEKVRSYGS 388
A E L + E Q + + + + + ++
Sbjct 798 NARKESLENKKSEKSEGDQKKPKDSKVTIAEYGEGEDEDKDPYPPCDVPVGEDEEDEEDE 857
Query 389 VLLSAEEFQKLFNELDRSVVKEHPPRPEY------QSPFLQSAQFLFGHYYFDYLGNLIA 442
+ A + +EL+ P +P L H+ F L +
Sbjct 858 PEVPAGPRPRRISELNMKEKITPIPEGSAFFIFSSTNPIRVGCHRLINHHIFTNLILVFI 917
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLS 498
+ + VS L + + + ILG + VF + E++LK+ A G +
Sbjct 918 MLSSVS----LAAEDPIRSHSFRNNILGYADYVFTSMFTFEIILKMTAFGAFLHKGSFCR 973
Query 499 YPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N+ D L+ V LV S + ++L +L V R LR
Sbjct 974 NYFNLLDLLVVGVSLV------------------SFGIQSSAISVVKILRVLRVLRPLRA 1015
Query 559 IPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
I K + V V ++ + + ++ ++FA IG+ LF+G + P
Sbjct 1016 INRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYKCTDEAKQNPEE 1075
Query 619 GSAPCGSFEQLEYWA------------NNFDDFAAALVTLWNLMVVNNWQVFL----DAY 662
++ + NFD+ +A++ L+ + W L D+
Sbjct 1076 CRGIYIVYKDGDVDNPMVKERVWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSN 1135
Query 663 RRYSGPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
GP +++ ++ + +N+F+ ++ F + + L
Sbjct 1136 GENVGPVYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQ 1195
Query 717 --TYQMTVELLFRDILEEP 733
Y + L R I + P
Sbjct 1196 CVEYALKARPLRRYIPKNP 1214
Score = 211 bits (538), Expect = 9e-56, Method: Composition-based stats.
Identities = 77/386 (20%), Positives = 141/386 (37%), Gaps = 46/386 (12%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEY-------QS 419
Q + +A + + S + ++ + RP +
Sbjct 49 QAAIDAARQAKAAQNMNTTTAQPVGSLSQRKRQQYAKSKKQGNTSNSRPPRALFCLSLNN 108
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P ++ L FD L AN V++ V++ D + + L + F++
Sbjct 109 PIRRACISLVEWKPFDIFILLSIFANCVALAVYIPFPEDDSNS--TNHNLEKVEYAFLII 166
Query 480 YLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVV---LLVLEISTLAVYRLPHPGWRP 532
+ +E LK+ A G Y+ N+ D ++ VV ++LE T H G +P
Sbjct 167 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVVVGLFSVILEQLTKETEGGSHSGGKP 226
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ + L V R LR++ + + VV ++++ + + +++ V +
Sbjct 227 GGFDV-------KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 279
Query 593 FAIIGINLFRGVIVALP-------------------GNSSLAPANGSAPCGSFEQLEYWA 633
+AIIG+ LF G + GN NG+ G +
Sbjct 280 YAIIGLELFIGKMHKSCFLIDSDILVEEDPAPCAFSGNGRQCVMNGTECKGGWVGPNGGI 339
Query 634 NNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLAL 692
NFD+FA A++T++ + + W L G W IYFV ++ S +NL L +
Sbjct 340 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGCEWPWIYFVSLIILGSFFVLNLVLGV 399
Query 693 ILENF---LHKWDPRSHLQPLAGTPE 715
+ F K R Q L +
Sbjct 400 LSGEFSKEREKAKARGDFQKLREKQQ 425
>sp|Q9W0Y8|SCN60_DROME Sodium channel protein 60E OS=Drosophila
melanogaster OX=7227 GN=NaCP60E PE=2 SV=6
Length=2844
Score = 431 bits (1107), Expect = 3e-130, Method: Composition-based stats.
Identities = 104/654 (16%), Positives = 240/654 (37%), Gaps = 91/654 (14%)
Query 73 LYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
+ + F L I S D+ + + +
Sbjct 1735 KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDI--NLDKNKTLKRVLYWINFSF 1792
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV--SLSLVCHEPLRIRRLL 190
L+F ++ +K G++ + + W + +++ VS+ + + +L LR R L
Sbjct 1793 CLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRAL 1852
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP + M+ + + +++P + +V L+ + +F++ G+ F G
Sbjct 1853 RPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGK--------- 1903
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+F+ + + LL + + D + +N + I F +G M L +
Sbjct 1904 ---FFKCV-NEMGELLPITEVNDKWDCI----EQNYTWINSKITFDHVG----MGYLALL 1951
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
+ F G+ M+ + ++ R + + E F + L + V
Sbjct 1952 QVATFEGW-MEVMADAVDARGVDLQPQREANLYAYIY---FVIFIVCGSFFTLNLFIGVI 2007
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF- 429
+D+ + + +K + E + + + + K+ P+ + P +
Sbjct 2008 IDNFN--MLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKK--PQKVIKRPINHFLAMFYD 2063
Query 430 --GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
F+ ++ N++++ + + FIL + N F + LE ++K
Sbjct 2064 LSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAV-----FFILEVSNAFFTTVFGLEAIVK 2118
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ L Y + P NVFD LL + + + + LP P ++ ++ ++ + R+L
Sbjct 2119 IVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMIDLP---ISPTLLRVVRVFRIGRIL 2174
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
++ + +R + ++ + + G +L ++ +++AI+G++LF V +
Sbjct 2175 RLIKAAKGIRKLLFA---------LVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ 2225
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR---R 664
+ + NF F ++ L+ LM W L++
Sbjct 2226 GALDDMV--------------------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP 2265
Query 665 YSGPW--------------SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPR 704
P+ + YF + ++S +I +N+++A+ILENF
Sbjct 2266 DCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEE 2319
Score = 229 bits (584), Expect = 1e-61, Method: Composition-based stats.
Identities = 59/331 (18%), Positives = 123/331 (37%), Gaps = 37/331 (11%)
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
++ + + + F++ ++ A+ +++C D ++ + +L +N
Sbjct 1733 SAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFE---DINLDKNKTLKRVLYWIN 1789
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
F + +++EM+LK ALG Y + + D ++ V +
Sbjct 1790 FSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSL----------------- 1832
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
++ + R L L R LR I + M +V + ++ + ++ + +V + +F
Sbjct 1833 LIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892
Query 594 AIIGINLFRGVIVALPGNSS--LAPANGSAPCGSFEQLEYWAN---NFDDFAAALVTLWN 648
+I+G+ F G L + EQ W N FD + L
Sbjct 1893 SIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQ 1952
Query 649 LMVVNNWQVFLDAYRRYSGP----------WSKIYFVLWWLVSSVIWVNLFLALILENF- 697
+ W + G ++ IYFV++ + S +NLF+ +I++NF
Sbjct 1953 VATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFN 2012
Query 698 -LHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
L K L+ + Y ++ L R
Sbjct 2013 MLKKKYEGGVLEMFLTESQKHYYTAMKKLGR 2043
Score = 119 bits (297), Expect = 5e-26, Method: Composition-based stats.
Identities = 51/320 (16%), Positives = 103/320 (32%), Gaps = 78/320 (24%)
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
SP + ++ + +FDY L N + + + ++ +F
Sbjct 111 PWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEE--------------AEYIF 156
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
+ Y +EM++K+ A G YL P N D ++ +
Sbjct 157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVI--------------TSGYATIGM 202
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
E+ L L V R L+ + M + + + +L + + + + V
Sbjct 203 EVGNLAG-------LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMV 255
Query 593 FAIIGINLFRGVIVALP-----------------------GNSSLAPANGSAPCGSF--- 626
FA+ + ++ G + N CG+
Sbjct 256 FALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGA 315
Query 627 -------------EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIY 673
E + NFD+F +++T + L+ ++ W+ + GP S +
Sbjct 316 RHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSF 375
Query 674 FVLWWLVSSVIWVNLFLALI 693
F + S +NL LA++
Sbjct 376 FTVVVFFGSFYLINLMLAVV 395
Score = 106 bits (265), Expect = 4e-22, Method: Composition-based stats.
Identities = 64/332 (19%), Positives = 118/332 (36%), Gaps = 52/332 (16%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
F + F+ L + N FL ++ + + L + N VF +
Sbjct 677 FQNCLYKVVRDPLFELAITLCIVLNT----AFLAMEHHGMSESFRN-ALDVGNKVFTSIF 731
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
E ++K+ AL + + N+FD L+ L+ I L G R V L+
Sbjct 732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQ 790
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
T M V+ S ++ + + ILV+V Y+FA+IG+ L
Sbjct 791 SWTT--------------------MKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQL 830
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F F+ NF+DF + + ++ ++ + D
Sbjct 831 FSK----------------DYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWD 874
Query 661 AYRRYSGPWSKIYFVLW---WLVSSVIWVNLFLALILENF-----LHKWDPRSHLQPLAG 712
R + F ++ ++ + + +NLFLAL+L +F K + LA
Sbjct 875 CMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLAR 934
Query 713 TPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ E + + R ++ E + E+ Q
Sbjct 935 SIERVRDLIRKK--RQERKDRKERKFAEKFQQ 964
Score = 94.0 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 31/153 (20%), Positives = 64/153 (42%), Gaps = 8/153 (5%)
Query 126 ESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH 181
E E + L +++ ++ +K G+L + +N W VV+ T+ + +
Sbjct 150 EEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG--YATIGMEVGNL 207
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
LR R+LR + +K + + S ++A V L L +F +F + ++ G
Sbjct 208 AGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGE 267
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANN 274
++ R+ T + N+ + + V T N
Sbjct 268 LRNKCV-RQVPTDWTNVSHTDWQIWVNDT-DNW 298
Score = 93.6 bits (231), Expect = 4e-18, Method: Composition-based stats.
Identities = 53/338 (16%), Positives = 113/338 (33%), Gaps = 18/338 (5%)
Query 50 VVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTA 109
VV I+D R+ + V + + + N + + +F + I ++ +
Sbjct 650 VVVIDDLPD-RNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAME 708
Query 110 DVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSL 169
+ + + +F + VK F W + L+++ SL
Sbjct 709 HHGMSESFRNA----LDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASL 763
Query 170 VDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
+D L +R L + MK L I ++ + ++ L+L I + +
Sbjct 764 LDIIFELVDGLSVLRGLRLLRVLKLAQS-WTTMKVLLSIIISTIGALGNLTLILVIVIYI 822
Query 230 FTMFGMLLFA--GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
F + GM LF+ + D F + S + +L + +
Sbjct 823 FAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEE 881
Query 288 YAIF-----FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLS 342
F+ V+G+ ++NL A++ + F +KS + + R+ V
Sbjct 882 QGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRD 941
Query 343 SMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM 380
+ + K + + Q++ LD+ A
Sbjct 942 LIRK---KRQERKDRKERKFAEKFQQIVLDAQQAHAQT 976
>sp|Q99244|CAC1D_MESAU Voltage-dependent L-type calcium channel
subunit alpha-1D OS=Mesocricetus auratus OX=10036 GN=CACNA1D
PE=2 SV=2
Length=1610
Score = 424 bits (1090), Expect = 2e-129, Method: Composition-based stats.
Identities = 114/641 (18%), Positives = 244/641 (38%), Gaps = 77/641 (12%)
Query 82 CQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
C + ++ IF L L FI S+ + D + G + +F ++
Sbjct 877 CHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILG---YFDYAFTAIFTVEIL 933
Query 142 VKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFLL 196
+K FG F +N + L ++V+ VSLV + + S + + LR+ R+LRP +
Sbjct 934 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 993
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+ +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 994 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYRCTDEAKSN--- 1049
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
PE L +L DV P + F F + L ++ S F
Sbjct 1050 --PEECRGLFILYKDG---DVDSPVVRERIWQNSDF-NFDNV----LSAMMALFTVSTFE 1099
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
G+ L ++ A V + V F + + ++ + + + +
Sbjct 1100 GWPA-LLYKAIDS---NGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQE 1155
Query 377 QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDY 436
Q E Y + L + Q + L ++ + P ++P+ ++ F+Y
Sbjct 1156 QGEKE----YKNCELDKNQRQCVEYALKARPLRRYIP----KNPYQYKFWYVVNSSPFEY 1207
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGY 496
+ ++ + N + + + ++ + + ILN VF + +EM+LKV A +GY
Sbjct 1208 MMFVLIMLNTLCLAM-----QHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGY 1262
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM---TRMLNMLIVF 553
S N FD L+ + ++ + A P S + V
Sbjct 1263 FSDAWNTFDSLIVIGSIIDVALSEADPTESESLPLPTATPGNSEESNRISITFFRLFRVM 1322
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R ++++ + + + T + Q + ++ ++++++A+IG+ +F V + +
Sbjct 1323 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQIN 1382
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---------DAYRR 664
F F A++ L+ WQ + D
Sbjct 1383 RNNN------------------FQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSD 1424
Query 665 Y--------SGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y ++ +YF+ ++++ + + +NLF+A+I++NF
Sbjct 1425 YNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1465
Score = 342 bits (878), Expect = 3e-100, Method: Composition-based stats.
Identities = 126/737 (17%), Positives = 265/737 (36%), Gaps = 119/737 (16%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F I L I + + + E VE L++F
Sbjct 114 IRRACISIVEWKPFDIFILLAIFANCVALAIY-IPFPEDDSNSTNHNLEKVEYAFLIIFT 172
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVS---------------LSL 178
+ +K +G + +N W L V+++V L +
Sbjct 173 VETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGG 232
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 233 FDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 292
Query 239 AGGKQDDG-------------------------------------QDRERLTYFQNLPES 261
G +T F N +
Sbjct 293 IGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAVNGTECRSGWVGPNGGITNFDNFAFA 352
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYAI-----FFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y N A +F+ + GS F++NL+ ++ +F
Sbjct 353 MLTVFQCITMEGWTDVL---YWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS 409
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK 376
K+ F++ R ++ + G QA + P+N + ++ + ++S
Sbjct 410 KEREKAKARGDFQK---LRENEQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMP 466
Query 377 QAMMEKVRSYGSVLLSAE-EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFL--FGHYY 433
+ E V + +S E E Q L +++ K R + +
Sbjct 467 TSETESVNTEN---VSGEGETQGSCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT 523
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F +L ++ N ++I D L I I N V + + EML+K+++LGL
Sbjct 524 FYWLVIVLVFLNTLTISSEHYNQPDWL-----TQIQDIANKVLLALFTCEMLVKMYSLGL 578
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+ Y N FD + + E + + + G + + +
Sbjct 579 QAYFVSLFNRFDCFVVCGG-ITETILVELELMSPLGVS--------------VFRCVRLL 623
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R ++ ++ + +++L ++++ + +L + +F+++G+ LF G
Sbjct 624 RIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------- 675
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWSK- 671
+F++ + + FD+F AL+T++ ++ +W V D Y GP S
Sbjct 676 -----------NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 724
Query 672 ----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
IYF++ ++ + I +N+FLA+ ++N + + A E E L
Sbjct 725 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLEN 784
Query 728 DILEEPGEDELTERLSQ 744
+P +++ ++
Sbjct 785 KKNNKPEVNQIANSDNK 801
Score = 281 bits (718), Expect = 4e-79, Method: Composition-based stats.
Identities = 130/717 (18%), Positives = 254/717 (35%), Gaps = 97/717 (14%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW 149
+L++ L F+ T + + Y W + L +F ++ VK Y G
Sbjct 525 YWLVIVLVFLNT----LTISSEHYNQPDWLTQIQDI--ANKVLLALFTCEMLVKMYSLGL 578
Query 150 AHFQKNLWL-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
+ +L+ VV + +++ +S + R RLLR F + ++ + +
Sbjct 579 QAYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNL 638
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSL 265
+ + S+ +AS+ LLL + + +F++ GM LF GGK + + + + + F N P++L ++
Sbjct 639 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLF-GGKFNFDETQTKRSTFDNFPQALLTV 697
Query 266 LVLLTTANNPDVMIPAY-------SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
+LT + VM S I+FI+ + G+ L+N+ AI
Sbjct 698 FQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLAD- 756
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
SL + E E + + + KV +D ++
Sbjct 757 -----AESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEE- 810
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP-------------PRPE--------Y 417
E Y + E ++ E P P PE
Sbjct 811 -TEDKDPYPPCDVPVGEEEEEEEEEPEVPAGPRPRRISELNMKEKIVPIPEGSAFFILSK 869
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+P L H+ F L + + + L + + + ILG + F
Sbjct 870 TNPIRVGCHKLINHHIFTNLILVFIMLS----SAALAAEDPIRSHSFRNTILGYFDYAFT 925
Query 478 VYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ +E+LLK+ G + N+ D L+ V LV
Sbjct 926 AIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLV------------------S 967
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
S + ++L +L V R LR I K + V V ++ + + ++ ++F
Sbjct 968 FGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMF 1027
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ------------LEYWANNFDDFAA 641
A IG+ LF+G + P ++ + NFD+ +
Sbjct 1028 ACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLS 1087
Query 642 ALVTLWNLMVVNNWQVFL----DAYRRYSGPWSK------IYFVLWWLVSSVIWVNLFLA 691
A++ L+ + W L D+ +GP I+F+++ ++ + +N+F+
Sbjct 1088 AMMALFTVSTFEGWPALLYKAIDSNGENAGPVYNHRVEISIFFIIYIIIVAFFMMNIFVG 1147
Query 692 LILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDILEEPGEDELTERLSQHP 746
++ F + + L Y + L R I + P + + ++ P
Sbjct 1148 FVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSP 1204
>sp|Q9JIS7|CAC1F_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1F OS=Mus musculus OX=10090 GN=Cacna1f PE=1
SV=1
Length=1985
Score = 427 bits (1098), Expect = 2e-129, Method: Composition-based stats.
Identities = 124/641 (19%), Positives = 247/641 (39%), Gaps = 79/641 (12%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C + IF L L FI S + D + G + +F
Sbjct 866 RKACHTLIHHHIFTSLILVFIILSSVSLAAEDPIRAHSFRNHILG---YFDYAFTSIFTV 922
Query 139 DLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPF 193
++ +K +FG F ++ + L L+V+ VSL+ + + S + + LR+ R+LRP
Sbjct 923 EILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPL 982
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLT 253
+ + +K ++C+ ++ + ++ ++ + +F G+ LF G K D +
Sbjct 983 RAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKG-KFYSCTDEAK-- 1039
Query 254 YFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYS 313
L ES S L+ DV P + F F + S +M L T +
Sbjct 1040 --HTLKESKGSFLIYPDG----DVSRPLVRERLWVNSDF-NFDNVLSA-MMALFTVSTFE 1091
Query 314 QFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDS 373
+ L K++ + + V F + + ++ + + +
Sbjct 1092 GWPALLYKAIDA-------NAEDEGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIIT 1144
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
Q E Y + L + Q + L ++ + P ++P
Sbjct 1145 FRAQGEQE----YQNCELDKNQRQCVEYALKAQPLRRYIP----KNPHQYRVWATVNSRA 1196
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F+YL L+ L N V++ + ++ + ILN VF + +EM+LK+ A
Sbjct 1197 FEYLMFLLILLNTVALAM-----QHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1251
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+ Y + N FD L+ V V++I+ V H G E +S + V
Sbjct 1252 KHYFADAWNTFDALIV-VGSVVDIAVTEVNNGGHLGESSEDTSRIS----ITFFRLFRVM 1306
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R ++++ + + + T + Q + ++ ++++++A+IG+ +F +VAL +
Sbjct 1307 RLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFG--LVALQDGTQ 1364
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY--RRYSGPWSK 671
+ NNF F A++ L+ WQ + A P S
Sbjct 1365 IN----------------RNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESD 1408
Query 672 ---------------IYFVLWWLVSSVIWVNLFLALILENF 697
+YF+ ++++ + + +NLF+A+I++NF
Sbjct 1409 FGPGEEFTCGSSFAIVYFISFFMLCAFLIINLFVAVIMDNF 1449
Score = 318 bits (816), Expect = 7e-92, Method: Composition-based stats.
Identities = 116/758 (15%), Positives = 249/758 (33%), Gaps = 161/758 (21%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C + + F IL L I + + + + E VE + L++F
Sbjct 81 IRRSCISIVEWKPFDILILLTI-FANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVIFT 139
Query 138 ADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-------------- 179
+ +K +G + + +N W L +++VV L +
Sbjct 140 VETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199
Query 180 -CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ + + I +L + + LL+ + ++ + G+ LF
Sbjct 200 FDVKALRAFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIYAIIGLELF 259
Query 239 AGGKQDDGQ-------------------------------------DRERLTYFQNLPES 261
G +T F N +
Sbjct 260 LGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGITNFDNFFFA 319
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYA-----IFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+ ++ +T DV+ Y A ++F+ + GS F++NL+ ++ +F
Sbjct 320 MLTVFQCITMEGWTDVL---YWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS 376
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAV-----GVKPQNLLQVLQKVQL 371
K+ F++ R ++ + G QA L L +
Sbjct 377 KEREKAKARGDFQK---LREKQQMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGR 433
Query 372 DSSHKQA----------------------------MMEKVRSYGSVLLSAEEFQ------ 397
Q + + +E +
Sbjct 434 AGHRPQLSELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTDTPGDEDEEEGTMA 493
Query 398 ---KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ N++ ++ + H R + + L+ N ++I
Sbjct 494 SCTRCLNKIMKTRICRHFRRA--NRGLRARCRRAVKSNACYWAVLLLVFLNTLTIA---- 547
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
N V + + +EMLLK++ LG Y++ N FD + +
Sbjct 548 -SEHHGQPLWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGG-I 605
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
LE + + V + G +L + + R ++ ++ + +++L
Sbjct 606 LETTLVEVGAMQPLGIS--------------VLRCVRLLRIFKVTRHWASLSNLVASLLN 651
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN 634
++++ + +L + +F+++G+ LF G +F+Q +
Sbjct 652 SMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-------------------NFDQTHTKRS 692
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL-DAYRRYSGPWS-----KIYFVLWWLVSSVIWVNL 688
FD F AL+T++ ++ +W V + D Y GP+ +YF++ ++ + I +N+
Sbjct 693 TFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCVYFIILFICGNYILLNV 752
Query 689 FLALILENFLH----KWDPRSHLQPLAGTPEATYQMTV 722
FLA+ ++N + + G P ++ V
Sbjct 753 FLAIAVDNLASGDAGTAKDKGREKSSEGNPPKENKVLV 790
Score = 314 bits (805), Expect = 2e-90, Method: Composition-based stats.
Identities = 130/727 (18%), Positives = 269/727 (37%), Gaps = 96/727 (13%)
Query 64 HRVDASSMWLYRRYYSN----VCQRTL--SFTIFLILFLAFIETPSSLTSTADVRYRAAP 117
+++ + + + R + C+R + + + +L L F+ T + A +
Sbjct 500 NKIMKTRICRHFRRANRGLRARCRRAVKSNACYWAVLLLVFLNT----LTIASEHHGQPL 555
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVLVVSL---VDWT 173
W E + L +F ++ +K Y G + + + + VV L +
Sbjct 556 WLTQTQ--EYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEV 613
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
++ + LR RLLR F + ++ + + + + S+ +AS+ LLL + + +F++
Sbjct 614 GAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLL 673
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-------NR 286
GM LF GGK + Q + + F P++L ++ +LT + VM
Sbjct 674 GMQLF-GGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGM 732
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
++FI+ + G+ L+N+ AI + R + + ++
Sbjct 733 LVCVYFIILFICGNYILLNVFLAIAVDNLASG--DAGTAKDKGREKSSEGNPPKENKVLV 790
Query 347 EGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
GG A G + + +++ + + ++ E+ G+ + EL +
Sbjct 791 PGGENEDAKGARSEGAAPGMEEEEEEEEEEEEEEEEEEENGAGHV----------ELLQE 840
Query 407 VVKEHP--PRPE--------YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD 456
VV + P PE +P ++ L H+ F L + + + VS L +
Sbjct 841 VVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHIFTSLILVFIILSSVS----LAAE 896
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL---RGYLSYPS-NVFDGLLTVVL 512
+ + ILG + F + +E+LLK+ G RG N+ D L+ V
Sbjct 897 DPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNLLDLLVVSVS 956
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
L+ S + ++L +L V R LR I K + V V
Sbjct 957 LI------------------SFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCV 998
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYW 632
++ + + ++ ++FA IG+ LF+G + + + +
Sbjct 999 FVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKESKGSFLIYPDGDVS 1058
Query 633 A------------NNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYF-- 674
NFD+ +A++ L+ + W L DA GP +
Sbjct 1059 RPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDANAEDEGPIYNYHVEI 1118
Query 675 ----VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRD 728
+++ ++ + +N+F+ ++ F + + L Y + + L R
Sbjct 1119 SVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRY 1178
Query 729 ILEEPGE 735
I + P +
Sbjct 1179 IPKNPHQ 1185
Score = 200 bits (508), Expect = 5e-52, Method: Composition-based stats.
Identities = 73/333 (22%), Positives = 132/333 (40%), Gaps = 37/333 (11%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+P +S + FD L L AN V++ V++ D + + L + VF+
Sbjct 78 TNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDD--SNTANHNLEQVEYVFL 135
Query 478 VYYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
V + +E +LK+ A G Y+ N+ D ++ VV L S L PG P
Sbjct 136 VIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL---FSVLLEQGPGRPGDAPH 192
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
G +D+ + L V R LR++ + + +V ++++ + + +++ V ++
Sbjct 193 TGGKPGGFDV-KALRAFRVLRPLRLVSGVPSLHIVVNSIMKALVPLLHIALLVLFVIIIY 251
Query 594 AIIGINLFRGVI-------------------VALPGNSSLAPANGSAPCGSFEQLEYWAN 634
AIIG+ LF G + A G+ N + G +
Sbjct 252 AIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSGRSCTLNHTECRGRWPGPNGGIT 311
Query 635 NFDDFAAALVTLWNLMVVNNWQV---FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
NFD+F A++T++ + + W ++ Y PW +YFV + S +NL L
Sbjct 312 NFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSFFVLNLVLG 369
Query 692 LILENF---LHKWDPRSHLQPLAGTPEATYQMT 721
++ F K R Q L + +
Sbjct 370 VLSGEFSKEREKAKARGDFQKLREKQQMEEDLR 402
>sp|Q02789|CAC1S_MOUSE Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Mus musculus OX=10090 GN=Cacna1s PE=1
SV=3
Length=1852
Score = 426 bits (1095), Expect = 2e-129, Method: Composition-based stats.
Identities = 134/711 (19%), Positives = 274/711 (39%), Gaps = 96/711 (14%)
Query 19 GGDWPAGLTTYR-SIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR-- 75
D+P I V P +L + + V I +A SS +++
Sbjct 738 SADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEA------------SSFFIFSPT 785
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+C R ++ T F L FI S+ + D + + E + + V
Sbjct 786 NKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRN---QILEYFDYVFTAV 842
Query 136 FAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLL 190
F ++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+L
Sbjct 843 FTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLRVL 902
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP + + +K ++C+ ++ + ++ L+ + +F G+ LF G K D
Sbjct 903 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG-KFYSCNDLS 961
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++T E + + + + + F F + L +++
Sbjct 962 KMT-----EEECRGYYYIYKDGDPTQIEL---RPRQWIHNDF-HFDNV----LSAMMSLF 1008
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
S F G+ + L ++ V ++ V F + + ++ +
Sbjct 1009 TVSTFEGWP-QLLYKAIDS---NEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFV 1064
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ + +Q E Y + L + Q + L ++ + P ++P+ ++
Sbjct 1065 IVTFQEQGETE----YKNCELDKNQRQCVQYALKARPLRCYIP----KNPYQYQVWYVVT 1116
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+YL + + N +IC+ + +E+ + I ILN F + + LEM+LK+ A
Sbjct 1117 SSYFEYLMFALIMLN--TICLGM---QHYNQSEQMNHISDILNVAFTIIFTLEMVLKLIA 1171
Query 491 LGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
RGY P NVFD L+ + +++ EI T +
Sbjct 1172 FKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
Query 547 ---LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G
Sbjct 1232 SAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-G 1290
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-- 661
I + G NNF F A++ L+ WQ L A
Sbjct 1291 KIAMVDGT-----------------QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS 1333
Query 662 YRRYSGPWS---------------KIYFVLWWLVSSVIWVNLFLALILENF 697
Y + P S YF+ ++++ + + +NLF+A+I++NF
Sbjct 1334 YGKLCDPESDYAPGEEHTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
Score = 330 bits (846), Expect = 9e-96, Method: Composition-based stats.
Identities = 126/739 (17%), Positives = 263/739 (36%), Gaps = 139/739 (19%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL---TESVEVLCLLV 135
C + + F + L I + Y P + L E +E L+V
Sbjct 41 RKACISIVEWKPFETIILLTIFANCVALAV----YLPMPEDDNNTLNLGLEKLEYFFLIV 96
Query 136 FAADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL--------------- 176
F+ + ++K +G+ + ++ W + +++ + + +
Sbjct 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKG 156
Query 177 SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
+ + + LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+
Sbjct 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query 237 LFAGGKQDDGQ----------------------------------------DRERLTYFQ 256
LF G +T+F
Sbjct 217 LFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFD 276
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQ 314
N S+ ++ ++ DV+ N I+F+ ++GS F++NL+ ++ +
Sbjct 277 NFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGE 336
Query 315 FRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSS 374
F K+ F++ R ++ + G Q +D
Sbjct 337 FTKEREKAKSRGTFQK---LREKQQLEEDLRGYMSWITQ--------------GEVMDVD 379
Query 375 HKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYF 434
+ + GS S E + L++ + R ++ F L F
Sbjct 380 DLREGKLSLDEGGSDTESLYEIEG----LNKIIQFIRHWR-QWNRVFRWKCHDLVKSKVF 434
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
+L LI N +SI + + N V + + +EML+K++ LGLR
Sbjct 435 YWLVILIVALNTLSIA-----SEHHNQPLWLTHLQDVANRVLLTLFTIEMLMKMYGLGLR 489
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y N FD + +LEI + + G +L + + R
Sbjct 490 QYFMSIFNRFDCFVVC-SGILEILLVESGAMSPLGIS--------------VLRCIRLLR 534
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
+I ++ + +++L ++++ + +L + +FA++G+ LF G
Sbjct 535 LFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRY--------- 585
Query 615 APANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWS--- 670
FE E +NFD+F AL++++ ++ +W V + Y GP
Sbjct 586 ----------DFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPTYPGV 635
Query 671 --KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
IYF++ ++ + I +N+FLA+ ++N L + + + Q +M+ L +
Sbjct 636 LVCIYFIILFVCGNYILLNVFLAIAVDN-LAEAESLTSAQKAKAEERKRRKMSKGLPDK- 693
Query 729 ILEEPGEDELTERLSQHPH 747
E +T++L Q
Sbjct 694 --SEEERATVTKKLEQKSK 710
Score = 321 bits (822), Expect = 1e-92, Method: Composition-based stats.
Identities = 134/742 (18%), Positives = 274/742 (37%), Gaps = 93/742 (13%)
Query 44 LCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLA 97
L +D+ E + +N + + R ++ V + + +L++ +
Sbjct 386 LSLDEGGSDTESLYEIEGLNKII---QFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIV 442
Query 98 FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
+ T S A + W + + L +F ++ +K Y G + +++
Sbjct 443 ALNT----LSIASEHHNQPLWLTHLQ--DVANRVLLTLFTIEMLMKMYGLGLRQYFMSIF 496
Query 158 L-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
VV ++ L+ + ++S + LR RLLR F + + + + + + S+
Sbjct 497 NRFDCFVVCSGILEILLVESGAMSPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSI 556
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
+AS+ LLL + + +F + GM LF GG+ D R + F N P++L S+ +LT +
Sbjct 557 RSIASLLLLLFLFIIIFALLGMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGED 615
Query 274 NPDVMIPAYSKNRAYA----------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKS 322
VM Y+ AY I+FI+ V G+ L+N+ AI + S
Sbjct 616 WNSVM---YNGIMAYGGPTYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMME 381
Q + R + + + E + + K + + K+++D + + E
Sbjct 673 AQKAKAEERKRRKMSKGLPDKSEEERATVTKKLEQKSKGEGIPTTAKLKIDEF-ESNVNE 731
Query 382 KVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHY 432
Y S ++ + L +KE P PE S F+ S
Sbjct 732 VKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVL 791
Query 433 YFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
+ L ++ L + + + IL + VF + +E++LK+
Sbjct 792 CHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKM 851
Query 489 FALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
G + N+ D L+ V L+ M S +
Sbjct 852 TTYGAFLHKGSFCRNYFNILDLLVVAVSLI------------------SMGLESSAISVV 893
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 894 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGK 953
Query 605 IVALPGNSSLAPANGSAPCGSFE------------QLEYWANNFDDFAAALVTLWNLMVV 652
+ S + ++ Q + +FD+ +A+++L+ +
Sbjct 954 FYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTF 1013
Query 653 NNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
W L D+ +GP I+F+++ ++ + +N+F+ ++ F + +
Sbjct 1014 EGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Query 703 PRSHLQPLAGTPEATYQMTVEL 724
L Q ++
Sbjct 1074 TEYKNCELDKNQRQCVQYALKA 1095
>sp|Q02485|CAC1S_RAT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Rattus norvegicus OX=10116 GN=Cacna1s PE=1
SV=2
Length=1850
Score = 425 bits (1092), Expect = 5e-129, Method: Composition-based stats.
Identities = 133/711 (19%), Positives = 273/711 (38%), Gaps = 96/711 (14%)
Query 19 GGDWPAGLTTYRSIQV-GPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR-- 75
D+P P +L + + V I +A SS +++
Sbjct 738 SADFPGDDEEDEPEIPASPRPRPLAELQLKEKAVPIPEA------------SSFFIFSPT 785
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+C R ++ T F L FI S+ + D + + E + + V
Sbjct 786 NKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRN---QILEYFDYVFTAV 842
Query 136 FAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLL 190
F ++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+L
Sbjct 843 FTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSAISVVKILRVLRVL 902
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP + + +K ++C+ ++ + ++ L+ + +F G+ LF G K D
Sbjct 903 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG-KFYSCNDLS 961
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++T E + + + + + F F + L +++
Sbjct 962 KMT-----EEECRGYYYIYKDGDPTQIEL---RPRQWIHNDF-HFDNV----LSAMMSLF 1008
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
S F G+ + L ++ V ++ V F + + ++ +
Sbjct 1009 TVSTFEGWP-QLLYKAIDS---NEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFV 1064
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ + +Q E Y + L + Q + L ++ + P ++P+ ++
Sbjct 1065 IVTFQEQGETE----YKNCELDKNQRQCVQYALKARPLRCYIP----KNPYQYQVWYVVT 1116
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+YL + + N +IC+ + +E+ + I ILN F + + LEM+LK+ A
Sbjct 1117 SSYFEYLMFALIMLN--TICLGM---QHYNQSEQMNHISDILNVAFTIIFTLEMILKLIA 1171
Query 491 LGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
RGY P NVFD L+ + +++ EI TL +
Sbjct 1172 FKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARIS 1231
Query 547 ---LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G
Sbjct 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-G 1290
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-- 661
I + G NNF F A++ L+ WQ L A
Sbjct 1291 KIAMVDGT-----------------QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS 1333
Query 662 YRRYSGPWS---------------KIYFVLWWLVSSVIWVNLFLALILENF 697
Y + P S YF+ ++++ + + +NLF+A+I++NF
Sbjct 1334 YGKRCDPESDYAPGEEYACGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
Score = 355 bits (911), Expect = 2e-104, Method: Composition-based stats.
Identities = 127/739 (17%), Positives = 264/739 (36%), Gaps = 139/739 (19%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL---TESVEVLCLLV 135
C + + F + L I + Y P + L E +E L+V
Sbjct 41 RKACISVVEWKPFETIILLTIFANCVALAV----YLPMPEDDNNTLNLGLEKLEYFFLIV 96
Query 136 FAADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL--------------- 176
F+ + ++K +G+ + ++ W + +++ + + +
Sbjct 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKG 156
Query 177 SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
+ + + LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+
Sbjct 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
Query 237 LFAGGKQDDGQ----------------------------------------DRERLTYFQ 256
LF G +T+F
Sbjct 217 LFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFD 276
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQ 314
N S+ ++ ++ DV+ N I+F+ ++GS F++NL+ ++ +
Sbjct 277 NFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGE 336
Query 315 FRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSS 374
F K+ F++ R ++ + G Q +D
Sbjct 337 FTKEREKAKSRGTFQK---LREKQQLEEDLRGYMSWITQ--------------GEVMDVD 379
Query 375 HKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYF 434
+ + GS S E + L++ + R ++ F L F
Sbjct 380 DLREGKLSLDEGGSDTESLYEIEG----LNKIIQFIRHWR-QWNRVFRWKCHDLVKSKVF 434
Query 435 DYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR 494
+L LI N +SI + + N V + + +EML+K++ LGLR
Sbjct 435 YWLVILIVALNTLSIA-----SEHHNQPLWLTHLQDVANRVLLALFTIEMLMKMYGLGLR 489
Query 495 GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y N FD + +LEI + + G +L + + R
Sbjct 490 QYFMSIFNRFDCFVVC-SGILEILLVESGAMTPLGIS--------------VLRCIRLLR 534
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
+I ++ + +++L ++++ + +L + +FA++G+ LF G
Sbjct 535 LFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRY--------- 585
Query 615 APANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWS--- 670
FE E +NFD+F AL++++ ++ +W V + Y GP
Sbjct 586 ----------DFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGV 635
Query 671 --KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
IYF++ ++ + I +N+FLA+ ++N L + + + Q +M+ L +
Sbjct 636 LVCIYFIILFVCGNYILLNVFLAIAVDN-LAEAESLTSAQKAKAEERKRRKMSRGLPDK- 693
Query 729 ILEEPGEDELTERLSQHPH 747
E +T++L Q P
Sbjct 694 --SEEERSTMTKKLEQKPK 710
Score = 344 bits (881), Expect = 2e-100, Method: Composition-based stats.
Identities = 133/743 (18%), Positives = 274/743 (37%), Gaps = 95/743 (13%)
Query 44 LCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLA 97
L +D+ E + +N + + R ++ V + + +L++ +
Sbjct 386 LSLDEGGSDTESLYEIEGLNKII---QFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIV 442
Query 98 FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
+ T S A + W + + L +F ++ +K Y G + +++
Sbjct 443 ALNT----LSIASEHHNQPLWLTHLQ--DVANRVLLALFTIEMLMKMYGLGLRQYFMSIF 496
Query 158 L-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
VV ++ L+ + +++ + LR RLLR F + + + + + + S+
Sbjct 497 NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSI 556
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
+AS+ LLL + + +F + GM LF GG+ D R + F N P++L S+ +LT +
Sbjct 557 RSIASLLLLLFLFMIIFALLGMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGED 615
Query 274 NPDVMIPAYSKNRAYA----------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKS 322
VM Y+ AY I+FI+ V G+ L+N+ AI + S
Sbjct 616 WNSVM---YNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMME 381
Q + R + + + E + + KP+ + K+++D + + E
Sbjct 673 AQKAKAEERKRRKMSRGLPDKSEEERSTMTKKLEQKPKGEGIPTTAKLKIDEF-ESNVNE 731
Query 382 KVRSYGSVLLSAEEFQKLFNELDRSVVKEHP----------PRPEYQSPFLQSAQFLFGH 431
Y S ++ + E+ S P PE S F+ S
Sbjct 732 VKDPYPSADFPGDDEED-EPEIPASPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRV 790
Query 432 YYFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ L ++ L + + + IL + VF + +E++LK
Sbjct 791 LCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLK 850
Query 488 VFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ G + N+ D L+ V L+ M S +
Sbjct 851 MTTYGAFLHKGSFCRNYFNILDLLVVAVSLI------------------SMGLESSAISV 892
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 893 VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKG 952
Query 604 VIVALPGNSSLAPANGSAPCGSFE------------QLEYWANNFDDFAAALVTLWNLMV 651
+ S + ++ Q + +FD+ +A+++L+ +
Sbjct 953 KFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVST 1012
Query 652 VNNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKW 701
W L D+ +GP I+F+++ ++ + +N+F+ ++ F +
Sbjct 1013 FEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQG 1072
Query 702 DPRSHLQPLAGTPEATYQMTVEL 724
+ L Q ++
Sbjct 1073 ETEYKNCELDKNQRQCVQYALKA 1095
>sp|P07293|CAC1S_RABIT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Oryctolagus cuniculus OX=9986 GN=CACNA1S
PE=1 SV=1
Length=1873
Score = 420 bits (1079), Expect = 4e-127, Method: Composition-based stats.
Identities = 134/711 (19%), Positives = 269/711 (38%), Gaps = 96/711 (14%)
Query 19 GGDWPAGLTTYR-SIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR-- 75
D+P I V P +L + + V I +A SS +++
Sbjct 738 SADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEA------------SSFFIFSPT 785
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+C R ++ T F L FI S+ + D + G ++ V
Sbjct 786 NKVRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILG---YFDIAFTSV 842
Query 136 FAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLL 190
F ++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+L
Sbjct 843 FTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSTISVVKILRVLRVL 902
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP + + +K ++C+ ++ + ++ L+ + +F G+ LF G D
Sbjct 903 RPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFS-CNDLS 961
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++T E + D + F F + L +++
Sbjct 962 KMT-----EEECRGYYYVYKDG---DPTQMELRPRQWIHNDF-HFDNV----LSAMMSLF 1008
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
S F G+ + L ++ V ++ V F + + ++ +
Sbjct 1009 TVSTFEGWP-QLLYRAIDS---NEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFV 1064
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ + +Q E Y + L + Q + L ++ + P ++P+ ++
Sbjct 1065 IVTFQEQGETE----YKNCELDKNQRQCVQYALKARPLRCYIP----KNPYQYQVWYVVT 1116
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+YL + + N +IC+ + +E + I ILN F + + LEM+LK+ A
Sbjct 1117 SSYFEYLMFALIMLN--TICLGM---QHYHQSEEMNHISDILNVAFTIIFTLEMILKLLA 1171
Query 491 LGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
RGY P NVFD L+ + +++ EI T +
Sbjct 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
Query 547 ---LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G
Sbjct 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-G 1290
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-- 661
I + G NNF F A++ L+ WQ L A
Sbjct 1291 KIALVDGT-----------------QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS 1333
Query 662 YRRYSGPWS---------------KIYFVLWWLVSSVIWVNLFLALILENF 697
Y + P S YF+ ++++ + + +NLF+A+I++NF
Sbjct 1334 YGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLIINLFVAVIMDNF 1384
Score = 339 bits (869), Expect = 8e-99, Method: Composition-based stats.
Identities = 130/739 (18%), Positives = 261/739 (35%), Gaps = 139/739 (19%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C + + F + L I + GL E +E L VF+
Sbjct 41 RKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL-EKLEYFFLTVFSI 99
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL---------------SLV 179
+ ++K +G+ + ++ W + +++ + + + + +
Sbjct 100 EAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVIQSNTAPMSSKGAGL 159
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 160 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFK 219
Query 240 GGKQDDGQ----------------------------------------DRERLTYFQNLP 259
G +T+F N
Sbjct 220 GKMHKTCYYIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFG 279
Query 260 ESLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
S+ ++ +T DV+ N I+F+ ++GS F++NL+ ++ +F
Sbjct 280 FSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK 339
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQ 377
K+ F++ R ++ + G Q +D +
Sbjct 340 EREKAKSRGTFQK---LREKQQLEEDLRGYMSWITQ--------------GEVMDVEDLR 382
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYL 437
+ GS S E + L++ + R ++ F L F +L
Sbjct 383 EGKLSLEEGGSDTESLYEIEG----LNKIIQFIRHWR-QWNRVFRWKCHDLVKSRVFYWL 437
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
LI N +SI + I N V + + +EMLLK++ LGLR Y
Sbjct 438 VILIVALNTLSIA-----SEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGLRQYF 492
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N FD + ++ E++ + S +++L R LR
Sbjct 493 MSIFNRFDCFVVCSGIL------------------ELLLVESGAMTPLGISVLRCIRLLR 534
Query 558 IIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
+ K +++ V L+ ++R + +L + +FA++G+ LF G
Sbjct 535 LFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRY--------- 585
Query 615 APANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQ-VFLDAYRRYSGPWS--- 670
FE E +NFD+F AL++++ ++ +W V + Y GP
Sbjct 586 ----------DFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGV 635
Query 671 --KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRD 728
IYF++ ++ + I +N+FLA+ ++N L + + + Q +M+ L +
Sbjct 636 LVCIYFIILFVCGNYILLNVFLAIAVDN-LAEAESLTSAQKAKAEERKRRKMSRGLPDKT 694
Query 729 ILEEPGEDELTERLSQHPH 747
E + + ++L Q P
Sbjct 695 ---EEEKSVMAKKLEQKPK 710
Score = 315 bits (808), Expect = 8e-91, Method: Composition-based stats.
Identities = 131/742 (18%), Positives = 269/742 (36%), Gaps = 93/742 (13%)
Query 44 LCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTL------SFTIFLILFLA 97
L +++ E + +N + + R ++ V + +L++ +
Sbjct 386 LSLEEGGSDTESLYEIEGLNKII---QFIRHWRQWNRVFRWKCHDLVKSRVFYWLVILIV 442
Query 98 FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
+ T S A + W + L +F ++ +K Y G + +++
Sbjct 443 ALNT----LSIASEHHNQPLWLTHLQDI--ANRVLLSLFTIEMLLKMYGLGLRQYFMSIF 496
Query 158 L-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
VV ++ L+ + +++ + LR RLLR F + + + + + + S+
Sbjct 497 NRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSI 556
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
+AS+ LLL + + +F + GM LF GG+ D R + F N P++L S+ +LT +
Sbjct 557 RSIASLLLLLFLFIIIFALLGMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGED 615
Query 274 NPDVMIPAYSKNRAYA----------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKS 322
VM Y+ AY I+FI+ V G+ L+N+ AI + S
Sbjct 616 WNSVM---YNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMME 381
Q + R + + + E + + KP+ + K+++D + + E
Sbjct 673 AQKAKAEERKRRKMSRGLPDKTEEEKSVMAKKLEQKPKGEGIPTTAKLKVDEF-ESNVNE 731
Query 382 KVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHY 432
Y S ++ + L +KE P PE S F+ S
Sbjct 732 VKDPYPSADFPGDDEEDEPEIPVSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKVRVL 791
Query 433 YFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
+ L ++ L + + + ILG + F + +E++LK+
Sbjct 792 CHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKM 851
Query 489 FALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
G + N+ D L+ V L+ M S +
Sbjct 852 TTYGAFLHKGSFCRNYFNILDLLVVAVSLI------------------SMGLESSTISVV 893
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
++L +L V R LR I K + V V ++ + + ++ ++FA IG+ LF+G
Sbjct 894 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGK 953
Query 605 IVALPGNSSLAPANGSAPCGSFE------------QLEYWANNFDDFAAALVTLWNLMVV 652
+ S + ++ Q + +FD+ +A+++L+ +
Sbjct 954 FFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTF 1013
Query 653 NNWQVFLD-AYRRYSGPWSKIY---------FVLWWLVSSVIWVNLFLALILENFLHKWD 702
W L A +Y F+++ ++ + +N+F+ ++ F + +
Sbjct 1014 EGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Query 703 PRSHLQPLAGTPEATYQMTVEL 724
L Q ++
Sbjct 1074 TEYKNCELDKNQRQCVQYALKA 1095
>sp|Q13698|CAC1S_HUMAN Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Homo sapiens OX=9606 GN=CACNA1S PE=1 SV=4
Length=1873
Score = 412 bits (1060), Expect = 2e-124, Method: Composition-based stats.
Identities = 131/711 (18%), Positives = 269/711 (38%), Gaps = 96/711 (14%)
Query 19 GGDWPAGLTTYRSIQV-GPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR-- 75
D+P P +L + + V I +A SS +++
Sbjct 738 SADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEA------------SSFFIFSPT 785
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+C R ++ T F L FI S+ + D + + + ++ V
Sbjct 786 NKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRN---QILKHFDIGFTSV 842
Query 136 FAADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLL 190
F ++ +K +G F +N + + L+V+ VSL+ + S + + LR+ R+L
Sbjct 843 FTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVL 902
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP + + +K ++C+ ++ + ++ L+ + +F G+ LF G D
Sbjct 903 RPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFF-RCTDLS 961
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
++T E + D M F F + L +++
Sbjct 962 KMT-----EEECRGYYYVYKDG---DPMQIELRHREWVHSDF-HFDNV----LSAMMSLF 1008
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
S F G+ + L ++ + ++ V F + + ++ +
Sbjct 1009 TVSTFEGWP-QLLYKAIDS---NAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFV 1064
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ + +Q E Y + L + Q + L ++ + P ++P+ ++
Sbjct 1065 IVTFQEQGETE----YKNCELDKNQRQCVQYALKARPLRCYIP----KNPYQYQVWYIVT 1116
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+YL + + N +IC+ + +E+ + I ILN F + + LEM+LK+ A
Sbjct 1117 SSYFEYLMFALIMLN--TICLGM---QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
Query 491 LGLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
RGY P NVFD L+ + +++ EI T +
Sbjct 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
Query 547 ---LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G
Sbjct 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-G 1290
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-- 661
I + G NNF F A++ L+ WQ L A
Sbjct 1291 KIALVDGT-----------------QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS 1333
Query 662 YRRYSGPWS---------------KIYFVLWWLVSSVIWVNLFLALILENF 697
Y + P S YF+ ++++ + + +NLF+A+I++NF
Sbjct 1334 YGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
Score = 351 bits (901), Expect = 4e-103, Method: Composition-based stats.
Identities = 125/736 (17%), Positives = 259/736 (35%), Gaps = 133/736 (18%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C + + F + L I + GL E +E L+VF+
Sbjct 41 RKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL-EKLEYFFLIVFSI 99
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL---------------SLV 179
+ ++K +G+ + ++ W + ++ + + + + +
Sbjct 100 EAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGL 159
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF
Sbjct 160 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFK 219
Query 240 GGKQDDGQ----------------------------------------DRERLTYFQNLP 259
G +T+F N
Sbjct 220 GKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFG 279
Query 260 ESLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
S+ ++ +T DV+ N I+F+ ++GS F++NL+ ++ +F
Sbjct 280 FSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK 339
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQ 377
K+ F++ R ++ + G Q +D +
Sbjct 340 EREKAKSRGTFQK---LREKQQLDEDLRGYMSWITQ--------------GEVMDVEDFR 382
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYL 437
+ GS S E L++ + R ++ F + F +L
Sbjct 383 EGKLSLDEGGSDTESLYEIAG----LNKIIQFIRHWR-QWNRIFRWKCHDIVKSKVFYWL 437
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
LI N +SI + I N V + + EML+K++ LGLR Y
Sbjct 438 VILIVALNTLSIA-----SEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYF 492
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N FD + +LEI + + G +L + + R +
Sbjct 493 MSIFNRFDCFVVC-SGILEILLVESGAMTPLGIS--------------VLRCIRLLRIFK 537
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
I ++ + +++L ++++ + +L + +FA++G+ LF G
Sbjct 538 ITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY------------ 585
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD-AYRRYSGPWS-----K 671
FE E +NFD+F AL++++ ++ +W + Y GP
Sbjct 586 -------DFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVC 638
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
IYF++ ++ + I +N+FLA+ ++N L + + + Q + +M+ L +
Sbjct 639 IYFIILFVCGNYILLNVFLAIAVDN-LAEAESLTSAQKAKAEEKKRRKMSKGLPDK---S 694
Query 732 EPGEDELTERLSQHPH 747
E + + ++L Q P
Sbjct 695 EEEKSTMAKKLEQKPK 710
Score = 329 bits (844), Expect = 1e-95, Method: Composition-based stats.
Identities = 128/742 (17%), Positives = 270/742 (36%), Gaps = 93/742 (13%)
Query 44 LCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTI------FLILFLA 97
L +D+ E + +N + + R ++ + + + +L++ +
Sbjct 386 LSLDEGGSDTESLYEIAGLNKII---QFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIV 442
Query 98 FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
+ T S A + W + L +F ++ +K Y G + +++
Sbjct 443 ALNT----LSIASEHHNQPLWLTRLQDI--ANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
Query 158 L-LGYLVV---LVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
VV ++ L+ + +++ + LR RLLR F + + + + + + S+
Sbjct 497 NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSI 556
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
+AS+ LLL + + +F + GM LF GG+ D R + F N P++L S+ +LT +
Sbjct 557 RSIASLLLLLFLFIVIFALLGMQLF-GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGED 615
Query 274 NPDVMIPAYSKNRAYA----------IFFIVFTVIGSLFLMNLLTAIIYSQF-RGYLMKS 322
+M Y+ AY I+FI+ V G+ L+N+ AI + S
Sbjct 616 WTSMM---YNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL-LQVLQKVQLDSSHKQAMME 381
Q + + + + + E + + KP+ + K+++D + + E
Sbjct 673 AQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEF-ESNVNE 731
Query 382 KVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHP-PRPEYQSPFLQSAQFLFGHY 432
Y S ++ + L +KE P PE S F+ S
Sbjct 732 VKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVL 791
Query 433 YFDYLGNL----IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKV 488
+ L ++ L + + + IL + F + +E++LK+
Sbjct 792 CHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKM 851
Query 489 FALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
G + N+ D L+ V L+ M S +
Sbjct 852 TTYGAFLHKGSFCRNYFNMLDLLVVAVSLI------------------SMGLESSAISVV 893
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
++L +L V R LR I K + V + + + + ++ ++FA IG+ LF+G
Sbjct 894 KILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGK 953
Query 605 IVALPGNSSLAPANGSAPCGSFE------------QLEYWANNFDDFAAALVTLWNLMVV 652
S + ++ + + +FD+ +A+++L+ +
Sbjct 954 FFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTF 1013
Query 653 NNWQVFL----DAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWD 702
W L D+ GP I+F+++ ++ + +N+F+ ++ F + +
Sbjct 1014 EGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGE 1073
Query 703 PRSHLQPLAGTPEATYQMTVEL 724
L Q ++
Sbjct 1074 TEYKNCELDKNQRQCVQYALKA 1095
>sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nicotiana
tabacum OX=4097 GN=TPC1A PE=2 SV=1
Length=735
Score = 388 bits (997), Expect = 4e-123, Method: Composition-based stats.
Identities = 175/777 (23%), Positives = 320/777 (41%), Gaps = 81/777 (10%)
Query 8 SEPLLGGARGGGGDWPA--GLTTYRSIQVGPG-----AAARWDLCIDQAVVFIEDAIQYR 60
E LL G G G R + G AAA DL D + E
Sbjct 2 EEYLLSGESSNSGRTRRRIGSIFDRRDAIAHGSAYQKAAALVDLAEDGIGLPEE------ 55
Query 61 SINHRVDASSMWLYRRYYSNVCQRTL--SFTIFLILFLAFIETP-----SSLTSTADVRY 113
++ +S Y + S ++ L F E P S + Y
Sbjct 56 ----ILEGASFEKAAELYFIFTRFDFLWSLNYLALVVLNFFEKPLWCSKHLAESCNNRDY 111
Query 114 RAAPWEPPCGLTES--VEVLCLLVFAADLSVKGYLFGWAHFQK---NLWLLGYLVVLVVS 168
P ES E + LL+ + G+ + + N + L++LV
Sbjct 112 YYLGELPFLTGAESLIFEGVTLLLLIIHILFPISYEGFNLYWRSLLNRVKVILLLILVAD 171
Query 169 LVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
+V + + L+ + P RI LR F + N ++ + + L +V L A+ L
Sbjct 172 IVVYILFLADFYYLPFRIAPYLRVVFFILNIRELRDSFFILAGMLGTYLNVVALSALFLL 231
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
+ + F +Q T F + +L + VL TT+NNPDV IPAY +R Y
Sbjct 232 FSSWLAYVFFEDTRQ-------GKTTFTSYGTTLYQMFVLFTTSNNPDVWIPAYKDSRWY 284
Query 289 AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEG 348
+FF+++ ++G F+ NL+ A++Y F+ L+K + R + AF ++ G
Sbjct 285 CLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVADKDRLRLRTLKKAFSLIDE-ANNG 343
Query 349 GAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVV 408
+ + + L + ++ +++ ++ G ++ +EF L +
Sbjct 344 HLNEKQCTLLFEELNKYRTLPKISGDDFKSIFSELDDTGDFKINLDEFADLCTAIGLRFQ 403
Query 409 KE-HPPRPE-----YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
KE P E Y SP + + F+Y+ + L NLV++ + LD
Sbjct 404 KEDSLPIFEACPNFYHSPASEKLRGFVRGATFEYIIVFVLLVNLVAVIIETTLDIQNNSG 463
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
+ + F Y++EM LKV+ G Y N FD ++T V+++ E +T
Sbjct 464 QT---FWQKVEFTFGWLYVIEMALKVYTYGFENYWRDGQNRFDFVVTWVIVIGETATFVA 520
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
P+ + LS + R L + + R +R++ ++ +T L+ ++ +
Sbjct 521 ---------PDGLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVATFFTLIPSLVPY 571
Query 583 GGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAA 642
G + + + +G+ +F G++ GN +LA + + +Y NF+D+
Sbjct 572 LGTIFCILCFYCSLGLQIFGGIVNT--GNPNLAQTDLAGN-------DYLLFNFNDYPNG 622
Query 643 LVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKW 701
+VTL+N++V+ NWQV++ +Y+ +G W+ YFV ++L+S + +NL +A +LE F +
Sbjct 623 MVTLFNILVMGNWQVWMQSYKELTGTAWTYAYFVSFYLISVLWLLNLIVAFVLEAFQAEV 682
Query 702 DPRSHLQPLAGTPE------------ATYQMTVELLFRDILEEPGEDELTERLSQHP 746
D + + + G + T V+ L +L ELTE +++P
Sbjct 683 DLEASARCVDGDDKEAKSERRRNVGTKTRSQRVDFLLHHMLRS----ELTECSNENP 735
>sp|Q24270|CAC1D_DROME Voltage-dependent calcium channel type
D subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=Ca-alpha1D
PE=1 SV=2
Length=2516
Score = 399 bits (1025), Expect = 3e-119, Method: Composition-based stats.
Identities = 121/710 (17%), Positives = 260/710 (37%), Gaps = 106/710 (15%)
Query 81 VCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
+C R + + F L L I + Y + E VE + L++F A+
Sbjct 607 LCIRIVEWKPFEFLILLTIFANCIALAVYTP-YPGSDSNVTNQTLEKVEYVFLVIFTAEC 665
Query 141 SVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL---SLVCHEPLRIRRLLRPF 193
+K +G+ + +N W L ++V+ + +S + LR R+LRP
Sbjct 666 VMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPL 725
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR---- 249
L+ ++ L I ++ + + LL+ + ++ + G+ LF+G +D
Sbjct 726 RLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGE 785
Query 250 ----------------------------ERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ +T F N ++ ++ +T DV+
Sbjct 786 YEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSI 845
Query 282 Y--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE 339
+ ++FI ++G+ F+MNL+ ++ +F K+ F++ R +
Sbjct 846 QDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQK---LREKQQ 902
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
+ + G QA ++P + ++ + ++ E + + E +
Sbjct 903 IEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWR- 961
Query 400 FNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADV 459
++ + ++ + F +L ++ N + D
Sbjct 962 --KMKKDF-------DRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDW 1012
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
L D N FI + EMLLK+++LG +GY N FD + I +
Sbjct 1013 L-----DNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVV-------IGS 1060
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
+ L + G P + +L + + R ++ + ++ + +++L +Q++
Sbjct 1061 ITETLLTNTGMMPPLGVS--------VLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSI 1112
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
+ +L + +FA++G+ +F G + E + NFD F
Sbjct 1113 ASLLLLLFLFIVIFALLGMQVFGGKFNFDG------------------KEEKYRMNFDCF 1154
Query 640 AAALVTLWNLMVVNNWQVFLD-AYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALI 693
AL+T++ +M +W + Y G S IYF++ ++ + I +N+FLA+
Sbjct 1155 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIA 1214
Query 694 LENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLS 743
++N + L+ + + P D + + LS
Sbjct 1215 VDNL-------ADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDDHLS 1257
Score = 374 bits (961), Expect = 7e-111, Method: Composition-based stats.
Identities = 103/650 (16%), Positives = 233/650 (36%), Gaps = 81/650 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C + + F + L I S++ + + + + + VF
Sbjct 1332 RFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRA---NDDLNKVLNKFDYFFTAVF 1388
Query 137 AADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLR 191
+L +K +G+ F ++ + L L+V+ VSL+ S + + + LR+ R+LR
Sbjct 1389 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLR 1448
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ L+ + +F + G+ LF G D +
Sbjct 1449 PLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFF-KCTDGSK 1507
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
+T + L ++ DV P + F V +LT
Sbjct 1508 MTQDECYGTYLVY--------DDGDVHKPRLREREWSNNRFHFDDV-----AKGMLTLFT 1554
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ L S+ + + + + + ++ + +
Sbjct 1555 VSTFEGWP-GLLYVSIDS---NKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1610
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ + E Y + L + + L V+ + P + +
Sbjct 1611 VTFQNEGEQE----YKNCDLDKNQRNCIEFALKAKPVRRYIP----KHGIQYKVWWFVTS 1662
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F+Y ++ + N V++ + +L LN +F + LE + K+ A
Sbjct 1663 SSFEYTIFILIMINTVTLAMKF-----YNQPLWYTELLDALNMIFTAVFALEFVFKLAAF 1717
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEI--------STLAVYRLPHPGWRPEMVGLLSLWDM 543
+ Y NVFD ++ + + + ++ G + S
Sbjct 1718 RFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1777
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + ++V++++++A++G+ +F G
Sbjct 1778 INFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-G 1836
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
I GN+ A NNF F A++ L+ WQ + +
Sbjct 1837 KIALDGGNAITA-----------------NNNFQTFQQAVLVLFRSATGEAWQEIMMSCS 1879
Query 664 RY----------------SGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
+ YF+ ++++ S + +NLF+A+I++NF
Sbjct 1880 AQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1929
Score = 339 bits (868), Expect = 1e-98, Method: Composition-based stats.
Identities = 133/778 (17%), Positives = 270/778 (35%), Gaps = 95/778 (12%)
Query 8 SEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQA--VVFIEDAIQYRSINHR 65
+ + G DW +T I+ D Q + E+ +
Sbjct 899 EKQQIEEDLRGYLDW---ITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQM 955
Query 66 VD------ASSMWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAP 117
+ R C++ + +LI+ L F+ T T Y
Sbjct 956 TESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLAT----EHYGQLD 1011
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL-LGYLVVL---VVSLVDWT 173
W E V + +F ++ +K Y G+ + +L+ VV+ +L+ T
Sbjct 1012 WLD--NFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNT 1069
Query 174 VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+ + LR RLLR F + + + + + S+ +AS+ LLL + + +F +
Sbjct 1070 GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALL 1129
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP---AYSKNRAYA- 289
GM +F G DG++ + F ++L ++ ++T + VM AY +Y
Sbjct 1130 GMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGA 1189
Query 290 ---IFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
I+FI+ + G+ L+N+ AI SL +A + S
Sbjct 1190 LACIYFIILFICGNYILLNVFLAIAVDNLAD--ADSLSEVEKEEEPHDESAQKKSHSPTP 1247
Query 347 EGGAFPQAVGVKPQNLLQVLQKV-QLD----SSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
+ + Q L ++D S + M + + +
Sbjct 1248 TIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMS 1307
Query 402 ELDRSVVKEHPPRP------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
E++ + P + F +L H F GN+I + S + L
Sbjct 1308 EVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNF---GNIILCCIMFSSAM-LAA 1363
Query 456 DADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVV 511
+ + + + +L + F + +E++LK+ + G + N+ D L+
Sbjct 1364 ENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVC- 1422
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+V + + ++L +L V R LR I K + V
Sbjct 1423 -----------------VSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQC 1465
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ--- 628
V+ V+ + + ++ ++FA+IG+ LF+G S + ++
Sbjct 1466 VIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDV 1525
Query 629 ------LEYWANN---FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYFV 675
W+NN FDD A ++TL+ + W L D+ + GP +
Sbjct 1526 HKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPI 1585
Query 676 L------WWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
+ + ++ + VN+F+ ++ F ++ + + + + +E +
Sbjct 1586 VAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ----EYKNCDLDKNQRNCIEFALK 1639
Score = 125 bits (313), Expect = 6e-28, Method: Composition-based stats.
Identities = 49/290 (17%), Positives = 100/290 (34%), Gaps = 53/290 (18%)
Query 70 SMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVE 129
+ + + V + +TIF L I T + Y W L +++
Sbjct 1649 KHGIQYKVWWFVTSSSFEYTIF---ILIMINTVTLAMK----FYNQPLWYTE--LLDALN 1699
Query 130 VLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW----------------- 172
++ VFA + K F + ++ + W + ++++ S +D
Sbjct 1700 MIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECD 1759
Query 173 ----------TVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLL 222
+ +L+ R+ R++R LL ++ L S + V LL
Sbjct 1760 IVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 1819
Query 223 LAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY 282
+ + ++ + GM +F D G FQ +++ L T ++M+
Sbjct 1820 IVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCS 1879
Query 283 SK-----------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
++ + +FI F V+ S ++NL A+I F
Sbjct 1880 AQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1929
>sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nicotiana
tabacum OX=4097 GN=TPC1B PE=2 SV=1
Length=735
Score = 377 bits (969), Expect = 5e-119, Method: Composition-based stats.
Identities = 168/740 (23%), Positives = 311/740 (42%), Gaps = 74/740 (10%)
Query 38 AAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTL--SFTIFLILF 95
AAA DL D + E ++ +S Y + S ++
Sbjct 39 AAALVDLAEDGIGLPEE----------ILEGASFEKAAELYFMFTRFDFLWSLNYLALVV 88
Query 96 LAFIETP-----SSLTSTADVRYRAAPWEPPCGLTES--VEVLCLLVFAADLSVKGYLFG 148
L F E P S + Y P ES E + LL+ + G
Sbjct 89 LNFFEKPLWCSKHLAESCNNRDYYYLGELPFLTGAESLIFEGVTLLLLIIHILFPISYEG 148
Query 149 WAHFQK---NLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
+ + + N + L++LV +V + + + + P RI LR F + N ++ +
Sbjct 149 FNLYWRSLLNRLKVILLLILVADIVVYILLPADFYYLPFRIAPYLRVVFFILNIRELRDS 208
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSL 265
+ L +V L A+ L + + F +Q T F + +L +
Sbjct 209 FFILAGMLGTYLNVVALSALFLLFSSWLAYVFFEDTRQ-------GKTTFTSYGTTLYQM 261
Query 266 LVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQT 325
VL TT+NNPDV IPAY +R Y +FF+++ ++G F+ NL+ A++Y F+ L+K +
Sbjct 262 FVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVAD 321
Query 326 SLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRS 385
R + AF ++ G + + + L + ++ +++ ++
Sbjct 322 KDRLRLRTLKKAFSLIDE-ANNGLLNEKQCTLLFEELNKYRTLPKISGDDFKSIFNELDD 380
Query 386 YGSVLLSAEEFQKLFNELDRSVVKE-HPPRPE-----YQSPFLQSAQFLFGHYYFDYLGN 439
G ++ EEF L + + KE P E Y SP + + F+Y+
Sbjct 381 TGDFKINLEEFADLCSAIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFIRGATFEYIIV 440
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY 499
+ L NLV++ + LD + + F Y++EM LKV+ G Y
Sbjct 441 FVLLVNLVAVIIETTLDIQNNSGQT---FWQKVEFTFGWLYVIEMALKVYTYGFENYWRD 497
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
N FD ++T V+++ E +T P+ + LS + R L + + R +R++
Sbjct 498 GQNRFDFIVTWVIVIGETTTFVA---------PDDLTFLSNGEWIRYLLIARMLRLIRLL 548
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
++ +T L L+ ++ + G + + + +G+ +F G++ GN +LA +
Sbjct 549 MHVERYRAFVATFLTLIPSLMPYLGTIFCILCFYCSLGLQIFGGIVNT--GNPNLAQTDL 606
Query 620 SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFVLWW 678
+ +Y NF+D+ +VTL+N++V+ NWQV++ +Y+ +G W+ YFV ++
Sbjct 607 AGN-------DYLLFNFNDYPNGMVTLFNILVMGNWQVWMQSYKELTGTSWTYAYFVSFY 659
Query 679 LVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE------------ATYQMTVELLF 726
L+S + +NL +A +LE F + D + + + G + T V+ L
Sbjct 660 LISVLWLLNLIVAFVLEAFQAEMDLEASARCVDGDDKEAKRERRRNVGTKTRSQRVDFLL 719
Query 727 RDILEEPGEDELTERLSQHP 746
+L ELTE + +P
Sbjct 720 HHMLRS----ELTECSNDNP 735
>sp|P22316|CAC1S_CYPCA Dihydropyridine-sensitive L-type skeletal
muscle calcium channel subunit alpha-1 OS=Cyprinus carpio
OX=7962 PE=2 SV=1
Length=1852
Score = 396 bits (1016), Expect = 1e-118, Method: Composition-based stats.
Identities = 117/710 (16%), Positives = 264/710 (37%), Gaps = 100/710 (14%)
Query 23 PAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY--RRYYSN 80
I + P DL + + VV I +A SS +++ + +
Sbjct 759 GDHEEVEPEIPISPRPRPMADLQLKETVVPIAEA------------SSFFIFGPQHKFRK 806
Query 81 VCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
+C R ++ T F + L FI S + D + + +++ VF ++
Sbjct 807 LCHRIVNHTTFTNIILLFILLSSISLAAEDPIDPRSFRN---KVLAYADIVFTTVFTIEI 863
Query 141 SVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLRPFFL 195
+K ++G F +N + + L+V+ VSL+ + S + + LR+ R+LRP
Sbjct 864 VLKMTVYGAFLHTGSFCRNSFNILDLIVVGVSLLSMGMESSTISVVKILRVLRVLRPLRA 923
Query 196 LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYF 255
+ + +K ++C+ ++ + ++ L+ + +F G+ LF G ++
Sbjct 924 INRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKLYYCTDPLQKT--- 980
Query 256 QNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
E + + D+ + ++ L +L S F
Sbjct 981 ---AEECQGTFLKHVPNSLHDIEVHQRM--------WVNSDFNFDNVLNGMLALFTISTF 1029
Query 316 RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH 375
G+ + L ++ + T + ++ VG F + + ++ + + +
Sbjct 1030 EGWP-EILYKAIDSNAVDTGP---LYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1085
Query 376 KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
KQ E Y L + Q + L +K + P ++P + YF+
Sbjct 1086 KQGEQE----YKDCELDKNQRQCVQYALKARPLKCYIP----KNPHQYRVWYFVTSCYFE 1137
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
YL + + N + + + +D + + LN +F V + EM++K+ A +G
Sbjct 1138 YLMFFLIMLNTLCLGIQHCNQSDHI-----TKLSDTLNLIFTVLFTGEMIVKLIAFKAKG 1192
Query 496 YLSYPSNVFDGLLTVVLLVLEIST------------LAVYRLPHPGWRPEMVGLLSLWDM 543
Y P NVFD ++ V +V + + ++ + ++
Sbjct 1193 YFGDPWNVFDFIIVVGSIVDVVLSEVDAALEARGGLWCLHGCAEVNPMQAIAEAENVRVS 1252
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ V R ++++ + + + T + Q + G ++V++++++A+IG+ +F
Sbjct 1253 ITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGK 1312
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
V + + NNF F A++ L+ + W + A
Sbjct 1313 VALVDGTEIN------------------RNNNFQTFPQAVLLLFRVATGEQWPKVILASM 1354
Query 664 -----------------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILEN 696
+ YF+ ++++ + + +NLF+A+I++N
Sbjct 1355 YGKLCDAKSDYGPGEEYTCGSSIAVFYFLSFYILCAFLIINLFVAIIMDN 1404
Score = 315 bits (807), Expect = 9e-91, Method: Composition-based stats.
Identities = 112/725 (15%), Positives = 245/725 (34%), Gaps = 136/725 (19%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ C + + F I+ L I + L ES+E + L++F
Sbjct 59 FRKTCINIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTL-ESLEYIFLVIFT 117
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL------------SLVCH 181
+ +K +G + +N W + V++ + L V
Sbjct 118 LECFLKIVAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTINTIAGVPTEKGGGFDM 177
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+ LR R+LRP L+ ++ + I S+ + + LL+ + ++ + G+ LF
Sbjct 178 KALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIYAIMGLELFKCK 237
Query 242 KQDDGQ-----------------------------------------DRERLTYFQNLPE 260
+T+F N
Sbjct 238 MHKTCYYQGTNIIAVREGNEKPSPCAQAGHGRRCTINGTECRAGWPGPNFGITHFDNSCF 297
Query 261 SLTSLLVLLTTANNPDV--MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
++ ++ +TT + DV I N I+F+ ++GS F++NL+ + +F
Sbjct 298 AMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLTLILVGSFFILNLVLGALSGEFTKE 357
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
+S +++ + ++ + G A + + +L + DS
Sbjct 358 REESRSRGEYQKLRERQ---QMDEDLEGYMEWITHAEVMDGDSEALLLLRKDTDSESDSL 414
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLG 438
++ F L R + + +F++
Sbjct 415 YQ-----------MLDQQVIYFYRLAR----------RWNVVLRRKCHVWVKSKFFNWWV 453
Query 439 NLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLS 498
L+ L N + I + E N + + + +EM++K++A G R Y
Sbjct 454 LLVVLLNTLVIAME-----HHNQTEGLTSFQDTANVILLACFTIEMVMKMYAFGPRAYFM 508
Query 499 YPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N FD + + +LEI + + G ++ + + R ++
Sbjct 509 SIFNRFDCFVVTIG-ILEIILVVSNIMTPLGIS--------------VMRCIRLLRLFKL 553
Query 559 IPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
+ + +++L V+++ + +L + +FA++G+ +F G
Sbjct 554 TRYWTSLNNLVASLLNSVKSIASLLLLLFLFIVIFALLGMQVFGGKF------------- 600
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD-AYRRYSGPWS-----KI 672
+F +NFD+F AL++++ ++ W + + GP S I
Sbjct 601 ------NFPDRVIQRSNFDNFPQALISVFQVLTGEEWDSIMYNGIMAHGGPQSPGILVSI 654
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEE 732
YF++ ++ + + +N+FLA+ ++N + L + + L E
Sbjct 655 YFIILYVCGNFVLLNVFLAIAVDNLAE-------AESLTAAQKEKAEEKARRKLMRTLPE 707
Query 733 PGEDE 737
E+E
Sbjct 708 KSEEE 712
Score = 310 bits (795), Expect = 4e-89, Method: Composition-based stats.
Identities = 126/733 (17%), Positives = 263/733 (36%), Gaps = 89/733 (12%)
Query 54 EDAIQYRSINHRVDASSMWLYR--RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
+ + S+ +D ++ YR R ++ V +R + F ++ L +
Sbjct 406 DTDSESDSLYQMLDQQVIYFYRLARRWNVVLRRKCHVWVKSKFFNWWVLLVVLLNTLVIA 465
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVD 171
E ++ V+ L F ++ +K Y FG + +++ V+ + +++
Sbjct 466 MEHHNQTEGLTSFQDTANVILLACFTIEMVMKMYAFGPRAYFMSIFNRFDCFVVTIGILE 525
Query 172 WTVSLS----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ +S + +R RLLR F L + + + + + S+ +AS+ LLL + +
Sbjct 526 IILVVSNIMTPLGISVMRCIRLLRLFKLTRYWTSLNNLVASLLNSVKSIASLLLLLFLFI 585
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY----- 282
+F + GM +F GGK + + + F N P++L S+ +LT +M
Sbjct 586 VIFALLGMQVF-GGKFNFPDRVIQRSNFDNFPQALISVFQVLTGEEWDSIMYNGIMAHGG 644
Query 283 --SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEV 340
S +I+FI+ V G+ L+N+ AI L ++ + ++ A
Sbjct 645 PQSPGILVSIYFIILYVCGNFVLLNVFLAIAVDN----LAEAESLTAAQKEKAEEKARRK 700
Query 341 LSSMVGEGGAFPQAVGVKPQNLLQVL-QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
L + E +A+ K + + + + K E + +F
Sbjct 701 LMRTLPEKSEEEKALMAKRLMESRSKAEGMPTTAKLKIDEFESNVNEVKDPFPPADFPGD 760
Query 400 FNELDRSVVKEHPPRP----------------------EYQSPFLQSAQFLFGHYYFDYL 437
E++ + PRP Q F + + H F +
Sbjct 761 HEEVEPEIPISPRPRPMADLQLKETVVPIAEASSFFIFGPQHKFRKLCHRIVNHTTFTNI 820
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR--- 494
L L + +S L + + P + +L + VF + +E++LK+ G
Sbjct 821 ILLFILLSSIS----LAAEDPIDPRSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHT 876
Query 495 -GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+ N+ D ++ V L+ M S + ++L +L V
Sbjct 877 GSFCRNSFNILDLIVVGVSLL------------------SMGMESSTISVVKILRVLRVL 918
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R LR I K + V + ++ + + +++ ++FA IG+ LF+G +
Sbjct 919 RPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKLYYCTDPLQ 978
Query 614 LAPANGSAP---------CGSFEQLEYWAN---NFDDFAAALVTLWNLMVVNNWQVFL-- 659
W N NFD+ ++ L+ + W L
Sbjct 979 KTAEECQGTFLKHVPNSLHDIEVHQRMWVNSDFNFDNVLNGMLALFTISTFEGWPEILYK 1038
Query 660 --DAYRRYSGPWSK------IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLA 711
D+ +GP I+F+++ ++ + +N+F+ ++ F + + L
Sbjct 1039 AIDSNAVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQKQGEQEYKDCELD 1098
Query 712 GTPEATYQMTVEL 724
Q ++
Sbjct 1099 KNQRQCVQYALKA 1111
Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats.
Identities = 72/367 (20%), Positives = 135/367 (37%), Gaps = 48/367 (13%)
Query 388 SVLLSAEEFQKLFNE-LDRSVVKEHPPRPEY-------QSPFLQSAQFLFGHYYFDYLGN 439
S +++ EE ++ E L + PRP ++PF ++ + F+ +
Sbjct 18 SFIMNEEELKRKQREKLKKLQATGGNPRPPRSLFFFTLKNPFRKTCINIVEWKPFEIIIL 77
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL----RG 495
L AN V++ VF L + L L +F+V + LE LK+ A GL
Sbjct 78 LTIFANCVALAVF--LPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIVAYGLLFHEGA 135
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
YL N+ D ++ + L + P + + L V R
Sbjct 136 YLRNCWNILDFVIVFMGLFTLVVDTINTIAGVPTEKGGGF-------DMKALRAFRVLRP 188
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP------ 609
LR++ + + VV S++L + + ++ + +++AI+G+ LF+ +
Sbjct 189 LRLVSGVPSLQVVMSSILKSMLPLFHIALLVFFMVHIYAIMGLELFKCKMHKTCYYQGTN 248
Query 610 -----------------GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
G+ NG+ + + +FD+ A++T++ +
Sbjct 249 IIAVREGNEKPSPCAQAGHGRRCTINGTECRAGWPGPNFGITHFDNSCFAMLTVFQCITT 308
Query 653 NNWQVFLDAYRRY-SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP---RSHLQ 708
+W L W IYF+ LV S +NL L + F + + R Q
Sbjct 309 ESWTDVLYWINDAMGNDWPWIYFLTLILVGSFFILNLVLGALSGEFTKEREESRSRGEYQ 368
Query 709 PLAGTPE 715
L +
Sbjct 369 KLRERQQ 375
>sp|O57483|CAC1S_AQUCT Voltage-dependent L-type calcium channel
subunit alpha-1S OS=Aquarana catesbeiana OX=8400 PE=2 SV=1
Length=1688
Score = 390 bits (1001), Expect = 6e-117, Method: Composition-based stats.
Identities = 122/685 (18%), Positives = 249/685 (36%), Gaps = 162/685 (24%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+C R ++ T F L FI S + D + + ++++ ++F
Sbjct 785 KIRVLCHRIINATTFTNFILLFILLSSISLAAEDPIQPESFRN---KVLSKLDIVFTVIF 841
Query 137 AADLSVKGYLFG----WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLR 191
++ +K +G F +N + + L V+ VSL+ + S + + LR+ R+LR
Sbjct 842 TTEIVLKMTAYGAFLHKGSFCRNSFNILDLSVVGVSLISMGIESSAISVVKILRVLRVLR 901
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ L+ + +F+ G+ LF G K D +
Sbjct 902 PLRAINRAKGLKHVVQCLFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKG-KFYSCTDTTK 960
Query 252 LT-------------------------------YFQNLPESLTSLLVLLTTANNP----- 275
+T +F N+ + SL + T P
Sbjct 961 ITADECRGYFFVAKDGNPAHMEAVPRVWSHSDFHFDNVLSGMMSLFTISTFEGWPQLLYR 1020
Query 276 ------DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFR 329
+ M P Y+ A+FFIV+ ++ + F+MN+ + F+
Sbjct 1021 AIDSHAEDMGPIYNYRIEIAVFFIVYIILIAFFMMNIFVGFVIVTFQEQGE--------- 1071
Query 330 RRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSV 389
Q + +LD + +Q +
Sbjct 1072 ----------------------------------QEYKDCELDKNQRQCVQ--------- 1088
Query 390 LLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSI 449
L ++ + P ++P ++ YF+YL + N +S+
Sbjct 1089 -----------YALKARPLRRYIP----KNPHQYKIWYVVTSSYFEYLMFFLITLNTISL 1133
Query 450 CVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT 509
+ ++ ILN F + +EM LK+ A +GY P NVFD L+
Sbjct 1134 GM-----QHYGQTAEFSYMSDILNVAFTGIFTVEMFLKLAAFKAKGYFGDPWNVFDFLIV 1188
Query 510 VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVA 569
+ ++ I + + PG S + V R ++++ + + +
Sbjct 1189 IGSVIDVI----LSEIDTPGIPATPGAEESSRISITFFRLFRVLRLVKLLSRGEGVRTLL 1244
Query 570 STVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQL 629
T + Q + ++V++++++A+IG+ +F G I + G
Sbjct 1245 WTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIALVDGTH----------------- 1286
Query 630 EYWANNFDDFAAALVTLWNLMVVNNWQVFLDA--YRRYSGPWS---------------KI 672
+NF F A++ L+ WQ L A Y + P S
Sbjct 1287 INRNSNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPMSDFQPGEEYTCGTSFAYF 1346
Query 673 YFVLWWLVSSVIWVNLFLALILENF 697
YF+ ++++ + + +NLF+A+I++NF
Sbjct 1347 YFISFYMLCAFLIINLFVAVIMDNF 1371
Score = 339 bits (868), Expect = 7e-99, Method: Composition-based stats.
Identities = 124/738 (17%), Positives = 253/738 (34%), Gaps = 137/738 (19%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ C + + F ++ L I + + E VE + L +F
Sbjct 40 FRKFCINIVEWKPFEMIILLTIFANCVALAIFLPMPEDDTNSTN-SVLEKVEYIFLFIFT 98
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVS-------------LSLVC 180
+ +K +G+ + +N W + ++ V + + S
Sbjct 99 IESFLKIVAYGFILHTDAYLRNGWNILDFTIVSVGVFSVLLEQISKLQGLPAPGKSSGFN 158
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ LR R+LRP L+ ++ L I ++ + + LL+ + ++ + G+ LF+G
Sbjct 159 VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFMIIIYAIVGLELFSG 218
Query 241 GKQDDGQ----------------------------------------DRERLTYFQNLPE 260
+T+F N
Sbjct 219 KMHKTCYFKDTDITATVDNEKPAPCSSTGQGRQCSINGSECRGWWPGPNNGITHFDNFGF 278
Query 261 SLTSLLVLLTTANNPDVMIPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY 318
++ ++ +T +V+ N I+F+ ++GS F++NL+ ++ +F
Sbjct 279 AMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLGVLSGEFTKE 338
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQA 378
K+ F+ +A E + G A + P
Sbjct 339 REKAKSRGAFQMLREQQAMDE---DLRGYLDWITHAEVMDPD------------------ 377
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPE-YQSPFLQSAQFLFGHYYFDYL 437
ME + + E L+ + + + + ++ L +F +L
Sbjct 378 -MEPRDGFSQLEEGGSETDSLYEIEGINKFIAFFRQWRLWHRLLRRKSRDLVKSRFFYWL 436
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
+I L N V I D L +D I N V + + +EM++K++ALG + Y
Sbjct 437 VIIIILLNTVIIATEHHHQPDSLTKAQD-----IANEVLLALFTMEMIVKIYALGFQSYF 491
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N FD + L LE+ +A + G +L + + R +
Sbjct 492 MSLFNRFDSFVVCTGL-LEVMLVASDIMSPLGIS--------------VLRCIRLLRIFK 536
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
I + + +++L V+++ + +L + +FA++G+ +F G
Sbjct 537 ITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKF------------ 584
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD-AYRRYSGPWSK----- 671
FE LE + FD F AL+T++ ++ +W + Y GP
Sbjct 585 -------DFEDLEVRRSTFDTFPQALITVFQILTGEDWTAVMYNGIMAYGGPTYSGMSVC 637
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
IYF++ ++ + I +N+FLA+ ++N + L +A +
Sbjct 638 IYFIILFVCGNYILLNVFLAIAVDNLAE-------AENLTSAQKAKAEERKRKKLARANP 690
Query 732 EPGEDE--LTERLSQHPH 747
+ E+E L + Q
Sbjct 691 DKTEEEKLLLAKKEQKAK 708
Score = 329 bits (843), Expect = 2e-95, Method: Composition-based stats.
Identities = 127/728 (17%), Positives = 264/728 (36%), Gaps = 87/728 (12%)
Query 71 MWLYRRYYSNVCQRTLS------FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL 124
+ R + + +R F +L++ + + T A +
Sbjct 409 FFRQWRLWHRLLRRKSRDLVKSRFFYWLVIIIILLNT----VIIATEHHHQPDSLTKAQD 464
Query 125 TESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LSLVC 180
+ L +F ++ VK Y G+ + +L+ V+ L++ + +S +
Sbjct 465 I--ANEVLLALFTMEMIVKIYALGFQSYFMSLFNRFDSFVVCTGLLEVMLVASDIMSPLG 522
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LR RLLR F + + + + + + S+ +AS+ LLL + + +F + GM +F G
Sbjct 523 ISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMF-G 581
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI--------PAYSKNRAYAIFF 292
GK D R + F P++L ++ +LT + VM P YS + I+F
Sbjct 582 GKFDFEDLEVRRSTFDTFPQALITVFQILTGEDWTAVMYNGIMAYGGPTYSG-MSVCIYF 640
Query 293 IVFTVIGSLFLMNLLTAIIYSQF-RGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF 351
I+ V G+ L+N+ AI + S Q + R + A E
Sbjct 641 IILFVCGNYILLNVFLAIAVDNLAEAENLTSAQKAKAEERKRKKLARANPDKTEEEKLLL 700
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN--------EL 403
+ + ++++D + + E Y S ++ ++ L
Sbjct 701 AKKEQKAKGEGIPTTARLKIDEF-ESNVNEIKDPYPSADFPGDDEEEEPEIPISPRPRPL 759
Query 404 DRSVVKEHP-PRPEYQSPFLQSAQFLFGHYYFDYLGNL----IALANLVSICVFLVLDAD 458
+KE P PE S F+ S + L ++ + L +
Sbjct 760 AELQLKEKAVPMPEASSFFIFSPTNKIRVLCHRIINATTFTNFILLFILLSSISLAAEDP 819
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLV 514
+ P + +L L+ VF V + E++LK+ A G + N+ D + V L+
Sbjct 820 IQPESFRNKVLSKLDIVFTVIFTTEIVLKMTAYGAFLHKGSFCRNSFNILDLSVVGVSLI 879
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
M S + ++L +L V R LR I K + V +
Sbjct 880 ------------------SMGIESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCLFV 921
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ------ 628
++ + + ++ ++F+ IG+ LF+G + + + +
Sbjct 922 AIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFYSCTDTTKITADECRGYFFVAKDGNPAHM 981
Query 629 ------LEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSK------I 672
+ +FD+ + +++L+ + W L D++ GP +
Sbjct 982 EAVPRVWSHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHAEDMGPIYNYRIEIAV 1041
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA--TYQMTVELLFRDIL 730
+F+++ ++ + +N+F+ ++ F + + L Y + L R I
Sbjct 1042 FFIVYIILIAFFMMNIFVGFVIVTFQEQGEQEYKDCELDKNQRQCVQYALKARPLRRYIP 1101
Query 731 EEPGEDEL 738
+ P + ++
Sbjct 1102 KNPHQYKI 1109
Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats.
Identities = 66/325 (20%), Positives = 123/325 (38%), Gaps = 38/325 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
Q+PF + + F+ + L AN V++ +FL + D + + +L + +F+
Sbjct 37 QNPFRKFCINIVEWKPFEMIILLTIFANCVALAIFLPMPEDDTNS--TNSVLEKVEYIFL 94
Query 478 VYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ +E LK+ A G YL N+ D + V + +V +
Sbjct 95 FIFTIESFLKIVAYGFILHTDAYLRNGWNILDFTIVSVGV------FSVLLEQISKLQGL 148
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
S + L V R LR++ + + VV ++++ + + +++ + ++
Sbjct 149 PAPGKSSGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMIPLLHIALLVLFMIIIY 208
Query 594 AIIGINLFRGVI----------------------VALPGNSSLAPANGSAPCGSFEQLEY 631
AI+G+ LF G + + G NGS G +
Sbjct 209 AIVGLELFSGKMHKTCYFKDTDITATVDNEKPAPCSSTGQGRQCSINGSECRGWWPGPNN 268
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFL 690
+FD+F A++T++ + + W L G W IYFV L+ S +NL L
Sbjct 269 GITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVL 328
Query 691 ALILENF---LHKWDPRSHLQPLAG 712
++ F K R Q L
Sbjct 329 GVLSGEFTKEREKAKSRGAFQMLRE 353
>sp|Q05152|CAC1B_RABIT Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Oryctolagus cuniculus OX=9986 GN=CACNA1B
PE=1 SV=1
Length=2339
Score = 383 bits (984), Expect = 5e-114, Method: Composition-based stats.
Identities = 130/697 (19%), Positives = 249/697 (36%), Gaps = 116/697 (17%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+R + F + LA I + + + P + E + +F
Sbjct 85 RKYAKRITEWPPFEYMILATI-IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCF 143
Query 139 DLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ +K G++ + +N W + ++VVL L L LR R+LRP
Sbjct 144 EAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---RTLRAVRVLRPL 200
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE--- 250
L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDP 260
Query 251 --------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVM 278
+T F N+ ++ ++ +T D++
Sbjct 261 DPVGDFPCGKEAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query 279 IPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRA 336
N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 321 YNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK---LRR 377
Query 337 AFEVLSSMVGEGGAFPQAVGV-KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
++ + G +A V + +K LD+ K+A +K R S L+ AEE
Sbjct 378 QQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDAVLKRAAAKKSR---SDLIQAEE 434
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH-YYFDYLGN-----------LIAL 443
+ L R +S +S+ + F + ++ +
Sbjct 435 GEGRLTGLCAPGSP--FARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWTVLCV 492
Query 444 ANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV 503
L ++CV +V +R L VF+ +L EM LK++ LG R Y N
Sbjct 493 VALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNC 549
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
FD +V + E+ AV + +++L R LRI K
Sbjct 550 FDF-GVIVGSIFEVVWAAVKPG-----------------TSFGISVLRALRLLRIFKVTK 591
Query 564 LMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
+ + V+ L+ +M+ + +L + VFA++G+ LF G +
Sbjct 592 YWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFKDETPT------- 644
Query 621 APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS-----GPWSKIYFV 675
NFD F AA++T++ ++ +W + G +S YF+
Sbjct 645 -------------TNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSRGMFSSFYFI 691
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ L + +N+FLA+ ++N + + + +
Sbjct 692 VLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEE 728
Score = 360 bits (924), Expect = 5e-106, Method: Composition-based stats.
Identities = 97/642 (15%), Positives = 215/642 (33%), Gaps = 91/642 (14%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C ++ F ++ L I S + D +P ++ + VF
Sbjct 1145 RRCCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSPRNNALK---YMDYIFTGVFTF 1201
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW----TVSLSLVCHEPLRIRRLL 190
++ +K L + ++LW + +V+ +LV + + + + LR+ R+L
Sbjct 1202 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDISTIKSLRVLRVL 1261
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1262 RPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-CTDES 1320
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-YAIFFIVFTVIGSLFLMNLLTA 309
+ + L D + + + + L LLT
Sbjct 1321 KELERDCRGQYL-------------DYEKEEVEAQPRQWKKYDFHYDNV----LWALLTL 1363
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
S G+ M + + V P + + +
Sbjct 1364 FTVSTGEGWPMVLKH----SVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVAL 1419
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q + L E + + + + P+ + F
Sbjct 1420 IIITFQEQGD----KVMSECSLEKNERACIDFAISARPLTRYMPQ--NKQSFQYKTWTFV 1473
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N V + + + +L LN VF + +E +LK+
Sbjct 1474 VSPPFEYFIMAMIALNTVVLMMKF-----YDAPYEYELMLKCLNIVFTSMFSMECVLKII 1528
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y NVFD + + + + T + + L +
Sbjct 1529 AFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSF----------------LRL 1572
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F + AL
Sbjct 1573 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI--ALD 1630
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY---- 665
++S+ NNF F AL+ L+ W + +
Sbjct 1631 DDTSIN----------------RHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSSRACD 1674
Query 666 --------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1675 EHSNASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1716
Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats.
Identities = 58/318 (18%), Positives = 112/318 (35%), Gaps = 49/318 (15%)
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP----------EYQSPFLQSAQF 427
V S L S E +K E++ S V PRP + + +
Sbjct 1094 GETTVVPSGNVDLESQAEGKK---EVETSDVMRSGPRPIVPYSSMFCLSPTNLLRRCCHY 1150
Query 428 LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ YF+ + ++ + ++ L + V + L ++ +F + EM++K
Sbjct 1151 IVTMRYFEMVILVVIALSSIA----LAAEDPVRTDSPRNNALKYMDYIFTGVFTFEMVIK 1206
Query 488 VFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ LG Y N+ D ++ LV A
Sbjct 1207 MIDLGLLLHPGAYFRDLWNILDFIVVSGALV----AFAFSGSKGKDIS-----------T 1251
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ L +L V R L+ I + + V V+ ++N+ + ++ ++FA+I + LF+G
Sbjct 1252 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKG 1311
Query 604 VIVALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALVTLWNLMVVNN 654
S + +E Q + + ++D+ AL+TL+ +
Sbjct 1312 KFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEG 1371
Query 655 WQVFL----DAYRRYSGP 668
W + L DA GP
Sbjct 1372 WPMVLKHSVDATYEEQGP 1389
Score = 169 bits (427), Expect = 8e-42, Method: Composition-based stats.
Identities = 69/328 (21%), Positives = 125/328 (38%), Gaps = 52/328 (16%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ + F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 82 NVVRKYAKRITEWPPFEY----MILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYF 137
Query 477 IVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D V+++ I A
Sbjct 138 IGIFCFEAGIKILALGFVLHKGSYLRNGWNVMDF----VVVLTGILATAGTDFD------ 187
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
R L + V R L+++ + + VV +++ + + G +L +
Sbjct 188 -----------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
Query 593 FAIIGINLFRGVIV-ALPGNSSLAPANGSAPCG----------SFEQLEYWA------NN 635
FAIIG+ + G A NS+ G PCG E EYWA N
Sbjct 237 FAIIGLEFYMGKFHKACFPNSTDPDPVGDFPCGKEAPARLCEGDTECREYWAGPNFGITN 296
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALIL 694
FD+ A++T++ + + W L +G W+ +YF+ ++ S +NL L ++
Sbjct 297 FDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 356
Query 695 ENFLHKW---DPRSHLQPLAGTPEATYQ 719
F + + R L + +
Sbjct 357 GEFAKERERVENRRAFLKLRRQQQIERE 384
Score = 132 bits (333), Expect = 2e-30, Method: Composition-based stats.
Identities = 52/287 (18%), Positives = 106/287 (37%), Gaps = 27/287 (9%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI R + + + + ++ V + I ++ L T + D
Sbjct 1445 IDFAISARPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIAL---NTVVLMMKFYDAP 1501
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVS---- 168
Y + + + ++ +F+ + +K FG ++ ++ W + V ++ S
Sbjct 1502 YEYEL------MLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDI 1555
Query 169 LVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
LV + + + LR+ R R LL+ ++ L S + V LL+A+
Sbjct 1556 LVTEIAN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1614
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS----- 283
++ + GM +F DD R F+ ++L L T ++M+ S
Sbjct 1615 IYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSSRACD 1674
Query 284 --------KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ +F+ F + S ++NL A+I F S
Sbjct 1675 EHSNASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1721
>sp|Q02294|CAC1B_RAT Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Rattus norvegicus OX=10116 GN=Cacna1b PE=1
SV=1
Length=2336
Score = 381 bits (979), Expect = 2e-113, Method: Composition-based stats.
Identities = 133/697 (19%), Positives = 254/697 (36%), Gaps = 116/697 (17%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+R + F + LA I + + + P + E + +F
Sbjct 85 RKYAKRITEWPPFEYMILATI-IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCF 143
Query 139 DLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ +K G++F + +N W + ++VVL L L LR R+LRP
Sbjct 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDL---RTLRAVRVLRPL 200
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE--- 250
L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
Query 251 --------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVM 278
+T F N+ ++ ++ +T D++
Sbjct 261 EPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query 279 IPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRA 336
N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 321 YNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK---LRR 377
Query 337 AFEVLSSMVGEGGAFPQAVGV-KPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
++ + G +A V + +K LD+ K+A +K R+ L+ AEE
Sbjct 378 QQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRN---DLIHAEE 434
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH-YYFDYLGN-----------LIAL 443
+ F +D R +S +S+ + F +L ++ +
Sbjct 435 GEDRF--VDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCV 492
Query 444 ANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV 503
L ++CV +V +R L VF+ +L EM LK++ LG R Y N
Sbjct 493 VALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNC 549
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
FD +V + E+ A+ + +++L R LRI K
Sbjct 550 FDF-GVIVGSIFEVVWAAIKPG-----------------TSFGISVLRALRLLRIFKVTK 591
Query 564 LMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
+ + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 592 YWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF------------- 638
Query 621 APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS-----GPWSKIYFV 675
Q E NFD F AA++T++ ++ +W + G +S YF+
Sbjct 639 -------QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFI 691
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ L + +N+FLA+ ++N + + + +
Sbjct 692 VLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEE 728
Score = 350 bits (899), Expect = 9e-103, Method: Composition-based stats.
Identities = 95/646 (15%), Positives = 210/646 (33%), Gaps = 95/646 (15%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C ++ F ++ L I S + D + ++ + VF
Sbjct 1138 RRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALK---YMDYIFTGVFTF 1194
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL--------SLVCHEPLRI 186
++ +K L + ++LW + +V+ +LV + S + + LR+
Sbjct 1195 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRV 1254
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1255 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-C 1313
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-YAIFFIVFTVIGSLFLMN 305
D + + L D + + + + L
Sbjct 1314 TDESKELERDCRGQYL-------------DYEKEEVEAQPRQWKKYDFHYDNV----LWA 1356
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
LLT S G+ M + + V P + +
Sbjct 1357 LLTLFTVSTGEGWPMVLKH----SVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNI 1412
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ + + +Q + L E + + + + P+ + F
Sbjct 1413 FVALIIITFQEQGD----KVMSECSLEKNERACIDFAISAKPLTRYMPQ--NKQSFQYKT 1466
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + +L LN VF + LE +
Sbjct 1467 WTFVVSPPFEYFIMAMIALNTVVLMMKF-----YDAPYEYELMLKCLNIVFTSMFSLECI 1521
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LK+ A G+ Y NVFD + + + + T + +
Sbjct 1522 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSF--------------- 1566
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R +++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1567 -LRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIA 1625
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR-- 663
+ + + NNF F AL+ L+ W + +
Sbjct 1626 LDDGTSIN------------------RHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGN 1667
Query 664 ----------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1668 RACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1713
Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats.
Identities = 54/315 (17%), Positives = 110/315 (35%), Gaps = 39/315 (12%)
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP-------EYQSPFLQSAQFLFG 430
V S + L E +K D P P + + ++
Sbjct 1087 GEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVT 1146
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ + ++ + ++ L + V + L ++ +F + EM++K+
Sbjct 1147 MRYFEMVILVVIALSSIA----LAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMID 1202
Query 491 LG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LG Y N+ D ++ LV A ++ + +
Sbjct 1203 LGLLLHPGAYFRDLWNILDFIVVSGALV----AFAFSSFMGGSKGKDI-------NTIKS 1251
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA+I + LF+G
Sbjct 1252 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1311
Query 607 ALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E Q + + ++D+ AL+TL+ + W +
Sbjct 1312 YCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPM 1371
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1372 VLKHSVDATYEEQGP 1386
Score = 169 bits (428), Expect = 6e-42, Method: Composition-based stats.
Identities = 70/328 (21%), Positives = 126/328 (38%), Gaps = 52/328 (16%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ + F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 82 NVVRKYAKRITEWPPFEY----MILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYF 137
Query 477 IVYYLLEMLLKVFALGLRG----YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D V+++ EI A
Sbjct 138 IGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDF----VVVLTEILATAGTDFD------ 187
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
R L + V R L+++ + + VV +++ + + G +L +
Sbjct 188 -----------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
Query 593 FAIIGINLFRGVIV-ALPGNSSLAPANGSAPCG----------SFEQLEYWA------NN 635
FAIIG+ + G A NS+ A G PCG E EYW N
Sbjct 237 FAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITN 296
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALIL 694
FD+ A++T++ + + W L +G W+ +YF+ ++ S +NL L ++
Sbjct 297 FDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 356
Query 695 ENFLHKW---DPRSHLQPLAGTPEATYQ 719
F + + R L + +
Sbjct 357 GEFAKERERVENRRAFLKLRRQQQIERE 384
Score = 127 bits (319), Expect = 1e-28, Method: Composition-based stats.
Identities = 50/287 (17%), Positives = 105/287 (37%), Gaps = 27/287 (9%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + + ++ V + I ++ L T + D
Sbjct 1442 IDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIAL---NTVVLMMKFYDAP 1498
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVS---- 168
Y + + + ++ +F+ + +K FG ++ ++ W + V ++ S
Sbjct 1499 YEYEL------MLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDI 1552
Query 169 LVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
LV + + + LR+ R R L + ++ L S + V LL+A+
Sbjct 1553 LVTEIAN-NFINLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1611
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS----- 283
++ + GM +F DDG R F+ ++L L T ++M+
Sbjct 1612 IYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACD 1671
Query 284 --------KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ +F+ F + S ++NL A+I F S
Sbjct 1672 PHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1718
>sp|O55017|CAC1B_MOUSE Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Mus musculus OX=10090 GN=Cacna1b PE=1
SV=1
Length=2327
Score = 379 bits (973), Expect = 2e-112, Method: Composition-based stats.
Identities = 130/696 (19%), Positives = 250/696 (36%), Gaps = 115/696 (17%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+R + F + LA I + + P + E + +F
Sbjct 85 RKYAKRITEWPPFEYMILATIIANCIVLALE-QHLPDGDKTPMSERLDDTEPYFIGIFCF 143
Query 139 DLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ +K G++F + +N W + ++VVL L L LR R+LRP
Sbjct 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---RTLRAVRVLRPL 200
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE--- 250
L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDT 260
Query 251 --------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVM 278
+T F N+ ++ ++ +T D++
Sbjct 261 EPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query 279 IPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRA 336
N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 321 YNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK---LRR 377
Query 337 AFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF 396
++ + G +A V + ++ K+A +K R+ L+ AEE
Sbjct 378 QQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAATKKSRN---DLIHAEEG 434
Query 397 QKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH-YYFDYLGN-----------LIALA 444
+ F +D V R +S +S+ + F + ++ +
Sbjct 435 EDRF--VDLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVV 492
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
L ++CV +V +R L VF+ +L EM LK++ LG R Y N F
Sbjct 493 ALNTLCVAMV---HYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCF 549
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL 564
D +V + E+ A+ + +++L R LRI K
Sbjct 550 DF-GVIVGSIFEVVWAAIKPG-----------------TSFGISVLRALRLLRIFKVTKY 591
Query 565 MAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
+ + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 592 WNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF-------------- 637
Query 622 PCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS-----GPWSKIYFVL 676
Q E NFD F AA++T++ ++ +W + G +S YF++
Sbjct 638 ------QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIV 691
Query 677 WWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
L + +N+FLA+ ++N + + + +
Sbjct 692 LTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEE 727
Score = 352 bits (904), Expect = 2e-103, Method: Composition-based stats.
Identities = 97/646 (15%), Positives = 214/646 (33%), Gaps = 95/646 (15%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C ++ F ++ L I S + D + ++ + VF
Sbjct 1129 RRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALK---YMDYIFTGVFTF 1185
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL--------SLVCHEPLRI 186
++ +K L + ++LW + +V+ +LV + S + + LR+
Sbjct 1186 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRV 1245
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1246 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-C 1304
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-YAIFFIVFTVIGSLFLMN 305
D + + L D + + + + L
Sbjct 1305 TDESKELERDCRGQYL-------------DYEKEEVEAQPRQWKKYDFHYDNV----LWA 1347
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
LLT S G+ M + + V P + +
Sbjct 1348 LLTLFTVSTGEGWPMVLKH----SVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNI 1403
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ + + +Q + L E + + + + P+ + F
Sbjct 1404 FVALIIITFQEQGD----KVMSECSLEKNERACIDFAISAKPLTRYMPQ--NKQSFQYKT 1457
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + +L LN VF + +E +
Sbjct 1458 WTFVVSPPFEYFIMAMIALNTVVLMMKF-----YDAPYEYELMLKCLNIVFTSMFSMECI 1512
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LK+ A G+ Y NVFD + + + + T + +
Sbjct 1513 LKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSF--------------- 1557
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1558 -LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI- 1615
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR-- 663
AL ++S+ NNF F AL+ L+ W + +
Sbjct 1616 -ALDDDTSIN----------------RHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGN 1658
Query 664 ----------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1659 RACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1704
Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats.
Identities = 54/315 (17%), Positives = 109/315 (35%), Gaps = 39/315 (12%)
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP-------EYQSPFLQSAQFLFG 430
V S L E +K D P P + + ++
Sbjct 1078 GETPVVPSGNMNLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVT 1137
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ + ++ + ++ L + V + L ++ +F + EM++K+
Sbjct 1138 MRYFEMVILVVIALSSIA----LAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMID 1193
Query 491 LG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LG Y N+ D ++ LV A ++ + +
Sbjct 1194 LGLLLHPGAYFRDLWNILDFIVVSGALV----AFAFSSFMGGSKGKDI-------NTIKS 1242
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA+I + LF+G
Sbjct 1243 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1302
Query 607 ALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E Q + + ++D+ AL+TL+ + W +
Sbjct 1303 YCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPM 1362
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1363 VLKHSVDATYEEQGP 1377
Score = 167 bits (424), Expect = 2e-41, Method: Composition-based stats.
Identities = 68/328 (21%), Positives = 124/328 (38%), Gaps = 52/328 (16%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ + F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 82 NVVRKYAKRITEWPPFEY----MILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYF 137
Query 477 IVYYLLEMLLKVFALGLRG----YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D V+++ I A
Sbjct 138 IGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDF----VVVLTGILATAGTDFD------ 187
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
R L + V R L+++ + + VV +++ + + G +L +
Sbjct 188 -----------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
Query 593 FAIIGINLFRGVIV-ALPGNSSLAPANGSAPCGSF----------EQLEYWA------NN 635
FAIIG+ + G A NS+ G PCG E EYW N
Sbjct 237 FAIIGLEFYMGKFHKACFPNSTDTEPVGDFPCGKDPPARQCDGDTECREYWPGPNFGITN 296
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALIL 694
FD+ A++T++ + + W L +G W+ +YF+ ++ S +NL L ++
Sbjct 297 FDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 356
Query 695 ENFLHKW---DPRSHLQPLAGTPEATYQ 719
F + + R L + +
Sbjct 357 GEFAKERERVENRRAFLKLRRQQQIERE 384
Score = 128 bits (322), Expect = 6e-29, Method: Composition-based stats.
Identities = 50/287 (17%), Positives = 105/287 (37%), Gaps = 27/287 (9%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + + ++ V + I ++ L T + D
Sbjct 1433 IDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIAL---NTVVLMMKFYDAP 1489
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVS---- 168
Y + + + ++ +F+ + +K FG ++ ++ W + V ++ S
Sbjct 1490 YEYEL------MLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDI 1543
Query 169 LVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
LV + + + LR+ R R LL+ ++ L S + V LL+A+
Sbjct 1544 LVTEIAN-NFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1602
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS----- 283
++ + GM +F DD R F+ ++L L T ++M+
Sbjct 1603 IYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACD 1662
Query 284 --------KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ +F+ F + S ++NL A+I F S
Sbjct 1663 PHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1709
>sp|Q00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel
subunit alpha-1B OS=Homo sapiens OX=9606 GN=CACNA1B PE=1 SV=1
Length=2339
Score = 379 bits (972), Expect = 2e-112, Method: Composition-based stats.
Identities = 132/696 (19%), Positives = 248/696 (36%), Gaps = 115/696 (17%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+R + F + LA I + + P + E + +F
Sbjct 85 RKYAKRITEWPPFEYMILATIIANCIVLALE-QHLPDGDKTPMSERLDDTEPYFIGIFCF 143
Query 139 DLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ +K G++F + +N W + ++VVL L L LR R+LRP
Sbjct 144 EAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---RTLRAVRVLRPL 200
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE--- 250
L+ ++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDA 260
Query 251 --------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVM 278
+T F N+ ++ ++ +T D++
Sbjct 261 EPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDIL 320
Query 279 IPAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRA 336
N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 321 YNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK---LRR 377
Query 337 AFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF 396
++ + G +A V + ++ K+A +K R+ L+ AEE
Sbjct 378 QQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRN---DLIHAEEG 434
Query 397 QKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH-YYFDYLGN-----------LIALA 444
+ F +L V R +S +S+ + F + ++ +
Sbjct 435 EDRFADL--CAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVV 492
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
L ++CV +V R L VF+ +L EM LK++ LG R Y N F
Sbjct 493 ALNTLCVAMV---HYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCF 549
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL 564
D +V V E+ A+ G +L R LRI K
Sbjct 550 DF-GVIVGSVFEVVWAAIKPGSSFGIS-----------------VLRALRLLRIFKVTKY 591
Query 565 MAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA 621
+ + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 592 WSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF-------------- 637
Query 622 PCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS-----GPWSKIYFVL 676
Q E NFD F AA++T++ ++ +W + G +S YF++
Sbjct 638 ------QDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIV 691
Query 677 WWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
L + +N+FLA+ ++N + + + +
Sbjct 692 LTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEE 727
Score = 359 bits (921), Expect = 1e-105, Method: Composition-based stats.
Identities = 99/642 (15%), Positives = 217/642 (34%), Gaps = 89/642 (14%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C ++ F ++ L I S + D +P + + VF
Sbjct 1140 RRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYL---DYIFTGVFTF 1196
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW----TVSLSLVCHEPLRIRRLL 190
++ +K L + ++LW + +V+ +LV + + + + LR+ R+L
Sbjct 1197 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVL 1256
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1257 RPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-CTDES 1315
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-YAIFFIVFTVIGSLFLMNLLTA 309
+ + L D + + + + L LLT
Sbjct 1316 KELERDCRGQYL-------------DYEKEEVEAQPRQWKKYDFHYDNV----LWALLTL 1358
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
S G+ M + + V P + + +
Sbjct 1359 FTVSTGEGWPMVLKH----SVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVAL 1414
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q + L E + + + + P+ + F
Sbjct 1415 IIITFQEQGD----KVMSECSLEKNERACIDFAISAKPLTRYMPQ--NRQSFQYKTWTFV 1468
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N V + + + +L LN VF + +E +LK+
Sbjct 1469 VSPPFEYFIMAMIALNTVVLMMKF-----YDAPYEYELMLKCLNIVFTSMFSMECVLKII 1523
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y NVFD +TV+ + +I + + + L +
Sbjct 1524 AFGVLNYFRDAWNVFDF-VTVLGSITDILVTEIAET-------------NNFINLSFLRL 1569
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F + AL
Sbjct 1570 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI--ALD 1627
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY---- 665
++S+ NNF F AL+ L+ W + +
Sbjct 1628 DDTSIN----------------RHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACD 1671
Query 666 --------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1672 EQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1713
Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats.
Identities = 56/315 (18%), Positives = 108/315 (34%), Gaps = 43/315 (14%)
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP-------EYQSPFLQSAQFLFG 430
V S L S E +K D P P + + ++
Sbjct 1089 GEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVT 1148
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ + ++ + ++ L + V + L L+ +F + EM++K+
Sbjct 1149 MRYFEVVILVVIALSSIA----LAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMID 1204
Query 491 LG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LG Y N+ D ++ LV A + +
Sbjct 1205 LGLLLHPGAYFRDLWNILDFIVVSGALV----AFAFSGSKGKDI-----------NTIKS 1249
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA+I + LF+G
Sbjct 1250 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1309
Query 607 ALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E Q + + ++D+ AL+TL+ + W +
Sbjct 1310 YCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPM 1369
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1370 VLKHSVDATYEEQGP 1384
Score = 168 bits (425), Expect = 1e-41, Method: Composition-based stats.
Identities = 69/328 (21%), Positives = 125/328 (38%), Gaps = 52/328 (16%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ + F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 82 NVVRKYAKRITEWPPFEY----MILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYF 137
Query 477 IVYYLLEMLLKVFALGLRG----YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D V+++ I A
Sbjct 138 IGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDF----VVVLTGILATAGTDFD------ 187
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
R L + V R L+++ + + VV +++ + + G +L +
Sbjct 188 -----------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM 236
Query 593 FAIIGINLFRGVIV-ALPGNSSLAPANGSAPCG----------SFEQLEYWA------NN 635
FAIIG+ + G A NS+ A G PCG E EYW N
Sbjct 237 FAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITN 296
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALIL 694
FD+ A++T++ + + W L +G W+ +YF+ ++ S +NL L ++
Sbjct 297 FDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 356
Query 695 ENFLHKW---DPRSHLQPLAGTPEATYQ 719
F + + R L + +
Sbjct 357 GEFAKERERVENRRAFLKLRRQQQIERE 384
Score = 129 bits (325), Expect = 2e-29, Method: Composition-based stats.
Identities = 51/288 (18%), Positives = 104/288 (36%), Gaps = 27/288 (9%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + + ++ V + I ++ L T + D
Sbjct 1440 IDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIAL---NTVVLMMKFYDAP 1496
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVS---- 168
Y + + + ++ +F+ + +K FG ++ ++ W + V ++ S
Sbjct 1497 YEYEL------MLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDI 1550
Query 169 LVDWTVSLSLVCHEP-LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
LV + + LR+ R R LL+ ++ L S + V LL+A+
Sbjct 1551 LVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1610
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN-- 285
++ + GM +F DD R F+ ++L L T ++M+ S
Sbjct 1611 FIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQAC 1670
Query 286 -----------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+F+ F + S ++NL A+I F S
Sbjct 1671 DEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1718
>sp|P56698|CAC1B_DIPOM Probable voltage-dependent N-type calcium
channel subunit alpha-1B OS=Diplobatis ommata OX=1870830
PE=2 SV=1
Length=2326
Score = 377 bits (968), Expect = 7e-112, Method: Composition-based stats.
Identities = 131/714 (18%), Positives = 252/714 (35%), Gaps = 114/714 (16%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+R + F + LA I + + + P + E + +F
Sbjct 77 IRKYAKRITEWPPFEYMILATI-IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFC 135
Query 138 ADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
+ +K G+ F + +N W + VV++ ++ + LR R+LRP
Sbjct 136 FEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILTTIG--TDFDLRTLRAVRVLRPL 193
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE--- 250
L+ ++ LK I ++ + +GLLL + +F + G+ + G E
Sbjct 194 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKTCFSEETNE 253
Query 251 -------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVMI 279
+T F N+ ++ ++ +T D++
Sbjct 254 PVEEFPCGTKYPSRLCPNGTVCKGYWNGPNFGITNFDNILFAVLTVFQCITMEGWTDMLY 313
Query 280 PAYS--KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
A N ++FI VIGS F++NL+ ++ +F + F + R
Sbjct 314 TANDALGNTWNWLYFIPLIVIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK---LRRQ 370
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+V A V + + K+A +K ++ L++AEE +
Sbjct 371 QQVEQEFNRYLRWIHIAEEVMLAEEDKNAEDKCALDVLKRATTKKSKN---DLINAEEGE 427
Query 398 KLFNELDRSVVKEHPPRPEYQSPFL-QSAQFLFGHYYFDYLGN-----------LIALAN 445
F ++ RP +S +S+ F F + ++ L
Sbjct 428 DHFTDISSVGFN----RPSLKSVKNERSSYFRRKEKRFRFFIRRMVKSQSFYWIVLCLVG 483
Query 446 LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
L ++CV +V L VF+ +L EM LK++ LG R Y N FD
Sbjct 484 LNTLCVAIV---HYDQPPLLTDALYFAEFVFLGLFLTEMSLKMYGLGPRNYFHSSFNCFD 540
Query 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
+V + E+ AV D + +++L R LRI K
Sbjct 541 F-GVIVGSIFEVVWTAVKP-----------------DTSFGISVLRALRLLRIFKVTKYW 582
Query 566 AVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
+ + V+ L+ +M+ + +L + VFA++G+ LF G G
Sbjct 583 NSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEDGTP---------- 632
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR-----YSGPWSKIYFVLW 677
NFD F AA++T++ ++ +W + G +S +YF++
Sbjct 633 ----------PTNFDTFPAAILTVFQILTGEDWNEVMYYGIEAHGGVKKGMFSSVYFIIL 682
Query 678 WLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
L + +N+FLA+ ++N + + + + + + D+
Sbjct 683 TLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEANIQKNTIQKAMEVADVSP 736
Score = 323 bits (827), Expect = 3e-93, Method: Composition-based stats.
Identities = 104/643 (16%), Positives = 213/643 (33%), Gaps = 91/643 (14%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C ++ F + L I S + D AP + + VF
Sbjct 1137 RRACHYIVNLRYFEMCILLVITMSSIALAAEDPVQGDAPRNNVLKYL---DYVFTGVFTF 1193
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
++ +K + + ++LW + +V+ +LV + L + LR+ R+L
Sbjct 1194 EMVIKMINLGLILHPGSYFRDLWNILDFIVVSGALVAFAFTGSRGKDLNTIKSLRVLRVL 1253
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
RP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1254 RPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY-CTDES 1312
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
+ L N+ P K + +++ LLT
Sbjct 1313 KDLEKDCRG-------QYLVYDNDEIEAEPREWKKCDFHYDNVLW---------ALLTLF 1356
Query 311 IYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQ 370
S G+ S + + V P + + +
Sbjct 1357 TVSTGEGWPTVLKN----SIDATEEDQGPSPSYRMEMSIFYVVYFVVFPFFFVNIFVALI 1412
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
+ + +Q S E+ ++ + S P+ + F
Sbjct 1413 IITFQEQGDKVMSDC------SLEKNERACIDFAISAKPLTRYMPQNKQTFQYKMWKFVV 1466
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
F+YL + N + + + D D +L LN +F + +E +LK+
Sbjct 1467 SPPFEYLIMALIALNTIVLMMKFYNAPD-----PYDRMLQYLNILFTFLFSMECVLKLIG 1521
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
G+ Y NVFD V ++ I+ + V L L +
Sbjct 1522 FGVLNYFRDAWNVFDF----VTVLGSITDILVTELADSFINLSF------------LRLF 1565
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPG 610
R ++++ + ++ T + + + ++ ++++++AIIG+ +F + + G
Sbjct 1566 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIELDDDG 1625
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS---- 666
+ NNF F A++ L WQ + A S
Sbjct 1626 AIN------------------RHNNFRTFLQAVMLLLRSATGEGWQEIMLACLNQSPCDA 1667
Query 667 ----------GPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + SS + +NLF+A+I++NF +
Sbjct 1668 RSGIDGDECGSNFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEY 1710
Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats.
Identities = 55/306 (18%), Positives = 110/306 (36%), Gaps = 43/306 (14%)
Query 391 LSAEEFQKLFN--ELDRSVVKEHPPRPEY-----QSPFLQSAQFLFGHYYFDYLGNLIAL 443
+ E +K N +L+ ++ PP +P ++ ++ YF+ L+
Sbjct 1099 VMKPEEKKAENGDDLNEDGPRQIPPFNSMFLFSTTNPVRRACHYIVNLRYFEMCILLVIT 1158
Query 444 ANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG----LRGYLSY 499
+ ++ L + V + +L L+ VF + EM++K+ LG Y
Sbjct 1159 MSSIA----LAAEDPVQGDAPRNNVLKYLDYVFTGVFTFEMVIKMINLGLILHPGSYFRD 1214
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
N+ D ++ LV T + + L +L V R L+ I
Sbjct 1215 LWNILDFIVVSGALVAFAFT---------------GSRGKDLNTIKSLRVLRVLRPLKTI 1259
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
+ + V V+ ++N+ + ++ ++FA+I + LF+G S +
Sbjct 1260 KRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKDLEKDC 1319
Query 620 SAPCGSFE------QLEYWA---NNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYS 666
++ + W ++D+ AL+TL+ + W L DA
Sbjct 1320 RGQYLVYDNDEIEAEPREWKKCDFHYDNVLWALLTLFTVSTGEGWPTVLKNSIDATEEDQ 1379
Query 667 GPWSKI 672
GP
Sbjct 1380 GPSPSY 1385
Score = 124 bits (310), Expect = 1e-27, Method: Composition-based stats.
Identities = 54/288 (19%), Positives = 108/288 (38%), Gaps = 27/288 (9%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + + + V + I ++ L I + D
Sbjct 1437 IDFAISAKPLTRYMPQNKQTFQYKMWKFVVSPPFEYLIMALIALNTIVLMMKFYNAPD-- 1494
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
P + + + +L +F+ + +K FG ++ ++ W + V ++ S+ D
Sbjct 1495 -------PYDRMLQYLNILFTFLFSMECVLKLIGFGVLNYFRDAWNVFDFVTVLGSITDI 1547
Query 173 TVSL---SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V+ S + LR+ R R LL+ ++ L S + V LL+A+ +
Sbjct 1548 LVTELADSFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1607
Query 230 FTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA 289
+ + GM +F + DD R F+ +++ LL T ++M+ +++ A
Sbjct 1608 YAIIGMQVFGNIELDDDGAINRHNNFRTFLQAVMLLLRSATGEGWQEIMLACLNQSPCDA 1667
Query 290 IFFIVFTVIGSLF---------------LMNLLTAIIYSQFRGYLMKS 322
I GS F ++NL A+I F S
Sbjct 1668 RSGIDGDECGSNFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDS 1715
>sp|P97445|CAC1A_MOUSE Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Mus musculus OX=10090 GN=Cacna1a PE=1
SV=2
Length=2368
Score = 369 bits (948), Expect = 3e-109, Method: Composition-based stats.
Identities = 120/651 (18%), Positives = 243/651 (37%), Gaps = 116/651 (18%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTV 174
P + E + +F + +K G+ F + +N W + ++VVL L
Sbjct 130 PMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT 189
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G
Sbjct 190 EFDL---RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIG 246
Query 235 MLLFAGGKQDDGQDR------------------------------------ERLTYFQNL 258
+ + G + +T F N+
Sbjct 247 LEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNI 306
Query 259 PESLTSLLVLLTTANNPDVMIPAY--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ ++ +T D++ + S N ++FI +IGS F++NL+ ++ +F
Sbjct 307 LFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 366
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQLDSSH 375
+ F + R ++ + G +A V ++ V Q+ D +
Sbjct 367 KERERVENRRAFLK---LRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGAL 423
Query 376 KQAMMEKVRSYGSVLLSAEEFQK-------LFNELDRSVVKEHPPRPE-----YQSPFLQ 423
++A ++K + + LL+ EE + + + R+ +K +
Sbjct 424 RRATLKKSK---TDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRF 480
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F + +++L L ++CV +V E L +F+ ++ E
Sbjct 481 YIRRMVKTQAFYW--TVLSLVALNTLCVAIV---HYNQPEWLSDFLYYAEFIFLGLFMSE 535
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M +K++ LG R Y N FD ++ + E+ +
Sbjct 536 MFIKMYGLGTRPYFHSSFNCFDC-GVIIGSIFEVIWAVIKPG-----------------T 577
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINL 600
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++G+ L
Sbjct 578 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 637
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F G G NFD F AA++T++ ++ +W +
Sbjct 638 FGGQFNFDEGTP--------------------PTNFDTFPAAIMTVFQILTGEDWNEVMY 677
Query 660 DAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
D + G IYF++ L + +N+FLA+ ++N + +
Sbjct 678 DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 728
Score = 349 bits (896), Expect = 2e-102, Method: Composition-based stats.
Identities = 97/644 (15%), Positives = 220/644 (34%), Gaps = 84/644 (13%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+C L+ F + L I S + D P P + + + VF
Sbjct 1185 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTF 1241
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW-----TVSLSLVCHEPLRIRRL 189
++ +K + + ++LW + +V+ +LV + + + + LR+ R+
Sbjct 1242 EMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRV 1301
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1302 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-CTDE 1360
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ + L +V ++R + + + + L+ L T
Sbjct 1361 SKEFERDCRGKYLLYE--------KNEVKA----RDREWKKYEFHYDNV-LWALLTLFTV 1407
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ L S+ + + + V P + + +
Sbjct 1408 STGEGWPQVLKHSVDATF-------ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVAL 1460
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q S E+ ++ + S P+ + F
Sbjct 1461 IIITFQEQGDKMMEE------YSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFV 1514
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N + + + + L + N VF + LE +LKV
Sbjct 1515 VSPPFEYTIMAMIALNTIVLMMKFYGASVAYEN-----ALRVFNIVFTSLFSLECVLKVM 1569
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y N+FD + + + + T + + L +
Sbjct 1570 AFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF----------------LRL 1613
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F
Sbjct 1614 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG------- 1666
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR------ 663
N + + + F+ E+ NNF F AL+ L+ W + +
Sbjct 1667 -NIGIDGEDEDSDEDEFQITEH--NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD 1723
Query 664 --------RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1724 KNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1767
Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats.
Identities = 55/315 (17%), Positives = 113/315 (36%), Gaps = 43/315 (14%)
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ--------SPFLQSAQFLFG 430
+++ ++ L +E +K E P P Y +P + ++
Sbjct 1134 VVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILN 1193
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ ++ + ++ L + V P + +L + VF + EM++K+
Sbjct 1194 LRYFEMCILMVIAMSSIA----LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMID 1249
Query 491 LGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LGL Y N+ D ++ LV + + +
Sbjct 1250 LGLVLHQGAYFRDLWNILDFIVVSGALV--------------AFAFTGNSKGKDINTIKS 1295
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA++ + LF+G
Sbjct 1296 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFF 1355
Query 607 ALPGNSSLAPANGSAPCGSFEQLE---------YWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E+ E + ++D+ AL+TL+ + W
Sbjct 1356 HCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQ 1415
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1416 VLKHSVDATFENQGP 1430
Score = 167 bits (424), Expect = 2e-41, Method: Composition-based stats.
Identities = 58/345 (17%), Positives = 119/345 (34%), Gaps = 46/345 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A+ + F+Y+ +AN + + + L D + L FI
Sbjct 87 NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER--LDDTEPYFIG 144
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ E +K+ ALG YL NV D ++ + ++ + T
Sbjct 145 IFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT--------------- 189
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
R L + V R L+++ + + VV +++ + + G +L +FA
Sbjct 190 ------EFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFA 243
Query 595 IIGINLFRGVIVALP------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IIG+ + G + NG+ +E F
Sbjct 244 IIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 303
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILE 695
D+ A++T++ + + W L SG W+ +YF+ ++ S +NL L ++
Sbjct 304 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 363
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
F + + + + + + + + E L E
Sbjct 364 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAE 408
Score = 150 bits (378), Expect = 8e-36, Method: Composition-based stats.
Identities = 73/368 (20%), Positives = 136/368 (37%), Gaps = 28/368 (8%)
Query 71 MWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
R +R + + +L L + T A V Y W
Sbjct 471 FHKKERRMRFYIRRMVKTQAFYWTVLSLVALNT----LCVAIVHYNQPEWLSD--FLYYA 524
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLVC---HEPL 184
E + L +F +++ +K Y G + + + V++ S+ + + L
Sbjct 525 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVL 584
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R RLLR F + + + ++ + + S+ + S+ LL + + +F + GM LF G Q
Sbjct 585 RALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG--QF 642
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN------RAYAIFFIVFTVI 298
+ + T F P ++ ++ +LT + +VM ++I+FIV T+
Sbjct 643 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLF 702
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQ----TSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
G+ L+N+ AI + ++L + A EV V A +
Sbjct 703 GNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAE--VSPLSAANMS 760
Query 355 VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLL--SAEEFQKLFNELDRSVVKEHP 412
+ VK Q Q K + + + + + L +AE + + R VK H
Sbjct 761 IAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRPDVKTHL 820
Query 413 PRPEYQSP 420
RP P
Sbjct 821 DRPLVVDP 828
Score = 124 bits (310), Expect = 2e-27, Method: Composition-based stats.
Identities = 54/296 (18%), Positives = 103/296 (35%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V +TI ++ L I A V
Sbjct 1486 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVL-MMKFYGASVA 1544
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y A ++ +F+ + +K FG ++ ++ W + V ++ S+ D
Sbjct 1545 YENALRV--------FNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDI 1596
Query 173 TV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V + + LR+ R R LL+ ++ L S + V LL+A+ +
Sbjct 1597 LVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1656
Query 230 FTMFGMLLFA--------GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + GM +F +D F+ ++L L T ++M+
Sbjct 1657 YAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSC 1716
Query 282 YSK---------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
S N +F+ F + S ++NL A+I F S
Sbjct 1717 LSGKPCDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1772
>sp|O00555|CAC1A_HUMAN Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Homo sapiens OX=9606 GN=CACNA1A PE=1
SV=3
Length=2506
Score = 369 bits (946), Expect = 6e-109, Method: Composition-based stats.
Identities = 117/651 (18%), Positives = 238/651 (37%), Gaps = 117/651 (18%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTV 174
P + E + +F + +K G+ F + +N W + ++VVL L
Sbjct 128 PMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT 187
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G
Sbjct 188 EFDL---RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIG 244
Query 235 MLLFAGGKQDDGQDR------------------------------------ERLTYFQNL 258
+ + G + +T F N+
Sbjct 245 LEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNI 304
Query 259 PESLTSLLVLLTTANNPDVMIPAY--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ ++ +T D++ + S N ++FI +IGS F++NL+ ++ +F
Sbjct 305 LFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 364
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQLDSSH 375
+ F + R ++ + G +A V ++ Q+ D+
Sbjct 365 KERERVENRRAFLK---LRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDALR 421
Query 376 KQAMMEKVRSYGSVLLSAEEFQK-------LFNELDRSVVKEHPPRPE-----YQSPFLQ 423
+ + + + LL+ EE + + + R+ +K +
Sbjct 422 RTTIKKSK----TDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRF 477
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F + +++L L ++CV +V E L +F+ ++ E
Sbjct 478 YIRRMVKTQAFYW--TVLSLVALNTLCVAIV---HYNQPEWLSDFLYYAEFIFLGLFMSE 532
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M +K++ LG R Y N FD ++ + E+ +
Sbjct 533 MFIKMYGLGTRPYFHSSFNCFDC-GVIIGSIFEVIWAVIKPG-----------------T 574
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINL 600
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++G+ L
Sbjct 575 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 634
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F G G NFD F AA++T++ ++ +W +
Sbjct 635 FGGQFNFDEGTP--------------------PTNFDTFPAAIMTVFQILTGEDWNEVMY 674
Query 660 DAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
D + G IYF++ L + +N+FLA+ ++N + +
Sbjct 675 DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 725
Score = 352 bits (904), Expect = 2e-103, Method: Composition-based stats.
Identities = 98/644 (15%), Positives = 221/644 (34%), Gaps = 84/644 (13%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+C L+ F + L I S + D P P + + + VF
Sbjct 1233 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTF 1289
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW-----TVSLSLVCHEPLRIRRL 189
++ +K + + ++LW + +V+ +LV + + + + LR+ R+
Sbjct 1290 EMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRV 1349
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1350 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-CTDE 1408
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ + L +V ++R + + + + L+ L T
Sbjct 1409 SKEFEKDCRGKYLLYE--------KNEVKA----RDREWKKYEFHYDNV-LWALLTLFTV 1455
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ L S+ + + + V P + + +
Sbjct 1456 STGEGWPQVLKHSVDATF-------ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVAL 1508
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q S E+ ++ + S P+ + F
Sbjct 1509 IIITFQEQGDKMMEE------YSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFV 1562
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N + + + + L + N VF + LE +LKV
Sbjct 1563 VSPPFEYTIMAMIALNTIVLMMKFYGASVAYEN-----ALRVFNIVFTSLFSLECVLKVM 1617
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y N+FD + + + + T + + L +
Sbjct 1618 AFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF----------------LRL 1661
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F
Sbjct 1662 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG------- 1714
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-------- 661
N + + + F+ E+ NNF F AL+ L+ W + +
Sbjct 1715 -NIGIDVEDEDSDEDEFQITEH--NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD 1771
Query 662 ------YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
R ++ YFV + + S + +NLF+A+I++NF +
Sbjct 1772 KNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1815
Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats.
Identities = 56/315 (18%), Positives = 114/315 (36%), Gaps = 43/315 (14%)
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ--------SPFLQSAQFLFG 430
+++ ++ L +E +K E D P P Y +P + ++
Sbjct 1182 VVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILN 1241
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ ++ + ++ L + V P + +L + VF + EM++K+
Sbjct 1242 LRYFEMCILMVIAMSSIA----LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMID 1297
Query 491 LGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LGL Y N+ D ++ LV + + +
Sbjct 1298 LGLVLHQGAYFRDLWNILDFIVVSGALV--------------AFAFTGNSKGKDINTIKS 1343
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA++ + LF+G
Sbjct 1344 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFF 1403
Query 607 ALPGNSSLAPANGSAPCGSFEQLE---------YWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E+ E + ++D+ AL+TL+ + W
Sbjct 1404 HCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQ 1463
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1464 VLKHSVDATFENQGP 1478
Score = 169 bits (428), Expect = 5e-42, Method: Composition-based stats.
Identities = 58/354 (16%), Positives = 120/354 (34%), Gaps = 46/354 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A+ + F+Y+ +AN + + + L D + L FI
Sbjct 85 NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER--LDDTEPYFIG 142
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ E +K+ ALG YL NV D ++ + ++ + T
Sbjct 143 IFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT--------------- 187
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
R L + V R L+++ + + VV +++ + + G +L +FA
Sbjct 188 ------EFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFA 241
Query 595 IIGINLFRGVIVALP------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IIG+ + G + NG+ +E F
Sbjct 242 IIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 301
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILE 695
D+ A++T++ + + W L SG W+ +YF+ ++ S +NL L ++
Sbjct 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLW 749
F + + + + + + + + E L E +
Sbjct 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRH 415
Score = 153 bits (387), Expect = 7e-37, Method: Composition-based stats.
Identities = 68/368 (18%), Positives = 134/368 (36%), Gaps = 26/368 (7%)
Query 71 MWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
R +R + + +L L + T A V Y W
Sbjct 468 FHKKERRMRFYIRRMVKTQAFYWTVLSLVALNT----LCVAIVHYNQPEWLSD--FLYYA 521
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLVC---HEPL 184
E + L +F +++ +K Y G + + + V++ S+ + + L
Sbjct 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVL 581
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R RLLR F + + + ++ + + S+ + S+ LL + + +F + GM LF G Q
Sbjct 582 RALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG--QF 639
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN------RAYAIFFIVFTVI 298
+ + T F P ++ ++ +LT + +VM ++I+FIV T+
Sbjct 640 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLF 699
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQ----TSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
G+ L+N+ AI + ++L + A EV A
Sbjct 700 GNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIA 759
Query 355 VGVKPQNLLQVLQ--KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP 412
V + +N + + KQ ++ + + + E ++ + R +K H
Sbjct 760 VKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHL 819
Query 413 PRPEYQSP 420
RP P
Sbjct 820 DRPLVVDP 827
Score = 124 bits (312), Expect = 7e-28, Method: Composition-based stats.
Identities = 54/296 (18%), Positives = 103/296 (35%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V +TI ++ L I A V
Sbjct 1534 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVL-MMKFYGASVA 1592
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y A ++ +F+ + +K FG ++ ++ W + V ++ S+ D
Sbjct 1593 YENALRV--------FNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDI 1644
Query 173 TV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V + + LR+ R R LL+ ++ L S + V LL+A+ +
Sbjct 1645 LVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1704
Query 230 FTMFGMLLFA--------GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + GM +F +D F+ ++L L T ++M+
Sbjct 1705 YAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSC 1764
Query 282 YSK---------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
S N +F+ F + S ++NL A+I F S
Sbjct 1765 LSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1820
>sp|P27884|CAC1A_RABIT Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Oryctolagus cuniculus OX=9986 GN=CACNA1A
PE=1 SV=1
Length=2424
Score = 368 bits (945), Expect = 8e-109, Method: Composition-based stats.
Identities = 121/657 (18%), Positives = 243/657 (37%), Gaps = 116/657 (18%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTV 174
P + E + +F + +K G+ F + +N W + ++VVL L
Sbjct 128 PMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT 187
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G
Sbjct 188 EFDL---RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIG 244
Query 235 MLLFAGGKQDDGQDR------------------------------------ERLTYFQNL 258
+ + G + +T F N+
Sbjct 245 LEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQFDNI 304
Query 259 PESLTSLLVLLTTANNPDVMIPAY--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ ++ +T D++ + S N ++FI +IGS F++NL+ ++ +F
Sbjct 305 LFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 364
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQLDSSH 375
+ F + R ++ + G +A V ++ V Q+ D +
Sbjct 365 KERERVENRRAFLK---LRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGAL 421
Query 376 KQAMMEKVRSYGSVLLSAEEFQK-------LFNELDRSVVKEHPPRPE-----YQSPFLQ 423
++A ++K + + LL EE + + + R+ +K +
Sbjct 422 RRATIKKSK---TDLLHPEEAEDQLADIASVGSPFARASIKSAKLENSSFFHKKERRMRF 478
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ + F + +++L L ++CV +V E L +F+ ++ E
Sbjct 479 YIRRMVKTQAFYW--TVLSLVALNTLCVAIV---HYNQPEWLSDFLYYAEFIFLGLFMSE 533
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M +K++ LG R Y N FD ++ + E+ +
Sbjct 534 MFIKMYGLGTRPYFHSSFNCFDC-GVIIGSIFEVIWAVIKPG-----------------T 575
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINL 600
+ +++L R LRI K A + + V+ L+ +M+ + +L + VFA++G+ L
Sbjct 576 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 635
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL- 659
F G G NFD F AA++T++ ++ +W +
Sbjct 636 FGGQFNFDEGTP--------------------PTNFDTFPAAIMTVFQILTGEDWNEVMY 675
Query 660 DAYRRYSGPWS----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
D + G IYF++ L + +N+FLA+ ++N + + Q
Sbjct 676 DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 732
Score = 347 bits (890), Expect = 2e-101, Method: Composition-based stats.
Identities = 99/644 (15%), Positives = 221/644 (34%), Gaps = 84/644 (13%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+C L+ F + L I S + D P P + + + VF
Sbjct 1243 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTF 1299
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW-----TVSLSLVCHEPLRIRRL 189
++ +K + + ++LW + +V+ +LV + + + + LR+ R+
Sbjct 1300 EMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRV 1359
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1360 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-CTDE 1418
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ + L +V ++R + + + + L+ L T
Sbjct 1419 SKEFEKDCRGKYLLYE--------KNEVKA----RDREWKKYEFHYDNV-LWALLTLFTV 1465
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ L S+ + + + V P + + +
Sbjct 1466 STGEGWPQVLKHSVDATF-------ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVAL 1518
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q S E+ ++ + S P+ + F
Sbjct 1519 IIITFQEQGDKMMEE------YSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFV 1572
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N + + + + D L + N VF + LE LLKV
Sbjct 1573 VSPPFEYTIMAMIALNTIVLMMKFYGASVAY-----DNALKVFNIVFTSLFSLECLLKVL 1627
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y N+FD + + + + T + + L +
Sbjct 1628 AFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF----------------LRL 1671
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F
Sbjct 1672 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG------- 1724
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-------- 661
N + + + F+ E+ NNF F AL+ L+ W + +
Sbjct 1725 -NIGIDMEDEDSDEDEFQITEH--NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD 1781
Query 662 ------YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1782 KNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1825
Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats.
Identities = 51/286 (18%), Positives = 102/286 (36%), Gaps = 40/286 (14%)
Query 405 RSVVKEHPPRPEY-----QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADV 459
K PP +P + ++ YF+ ++ + ++ L + V
Sbjct 1221 EDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA----LAAEDPV 1276
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVL 515
P + +L + VF + EM++K+ LGL Y N+ D ++ LV
Sbjct 1277 QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALV- 1335
Query 516 EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+ + + L +L V R L+ I + + V V+
Sbjct 1336 -------------AFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNS 1382
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE----- 630
++N+ + ++ ++FA++ + LF+G S + +E+ E
Sbjct 1383 LKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARD 1442
Query 631 ----YWANNFDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGP 668
+ ++D+ AL+TL+ + W L DA GP
Sbjct 1443 REWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1488
Score = 166 bits (419), Expect = 7e-41, Method: Composition-based stats.
Identities = 58/345 (17%), Positives = 119/345 (34%), Gaps = 46/345 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A+ + F+Y+ +AN + + + L D + L FI
Sbjct 85 NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER--LDDTEPYFIG 142
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ E +K+ ALG YL NV D ++ + ++ + T
Sbjct 143 IFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT--------------- 187
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
R L + V R L+++ + + VV +++ + + G +L +FA
Sbjct 188 ------EFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFA 241
Query 595 IIGINLFRGVIVALP------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IIG+ + G + NG+ +E F
Sbjct 242 IIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTRCQPYWEGPNNGITQF 301
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILE 695
D+ A++T++ + + W L SG W+ +YF+ ++ S +NL L ++
Sbjct 302 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 361
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
F + + + + + + + + E L E
Sbjct 362 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAE 406
Score = 123 bits (308), Expect = 2e-27, Method: Composition-based stats.
Identities = 54/296 (18%), Positives = 104/296 (35%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V +TI ++ L I A V
Sbjct 1544 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVL-MMKFYGASVA 1602
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y A + ++ +F+ + +K FG ++ ++ W + V ++ S+ D
Sbjct 1603 YDNA--------LKVFNIVFTSLFSLECLLKVLAFGILNYFRDAWNIFDFVTVLGSITDI 1654
Query 173 TV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V + + LR+ R R LL+ ++ L S + V LL+A+ +
Sbjct 1655 LVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1714
Query 230 FTMFGMLLFA--------GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + GM +F +D F+ ++L L T ++M+
Sbjct 1715 YAIIGMQVFGNIGIDMEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSC 1774
Query 282 YSK---------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
S N +F+ F + S ++NL A+I F S
Sbjct 1775 LSGKPCDKNSGILTPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1830
>sp|Q25452|CAC1M_MUSDO Muscle calcium channel subunit alpha-1
OS=Musca domestica OX=7370 PE=2 SV=1
Length=1687
Score = 367 bits (941), Expect = 1e-108, Method: Composition-based stats.
Identities = 111/703 (16%), Positives = 262/703 (37%), Gaps = 102/703 (15%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
C + + +F L I + Y + + E +E + L++F +
Sbjct 51 RIFCIKIVDSKLFEYFILLTIFANCVALAVYTP-YPSGDSNITNQMLEKIEYIFLVIFTS 109
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVS---LSLVCHEPLRIRRLLR 191
+ +K +G+ + +N W ++V+ ++ +S + LR R+LR
Sbjct 110 ECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNLVKEGFDVKALRAFRVLR 169
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE- 250
P L+ ++ L I ++ + + LL+ + ++ + G+ LF+G +
Sbjct 170 PLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTCRHSNT 229
Query 251 ----------------------------------RLTYFQNLPESLTSLLVLLTTANNPD 276
+T F N S+ ++ +T D
Sbjct 230 GEYLNDLDELHACGVGFKCPSGYECFDDWVGPNDGITNFDNFGLSMLTVFQCITLEGWTD 289
Query 277 VMIPAY--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT 334
V+ + I+F+ ++G+ F+MNL+ ++ +F K+ F++
Sbjct 290 VLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFSKERTKAKNRGDFQK---L 346
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R ++ + G QA ++P Q+++ + + ++ ++ + + +
Sbjct 347 REKQQIEEDLRGYLDWITQAEDIEPDPDAQIIEDCHKNKVKEVVSIDNLKDHENETQQTD 406
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ + K++ R ++ + F +L L+ N ++
Sbjct 407 SWFR--------SQKKYLER--INRRIRRACRKAVKSQAFYWLIILLVFLNT-----GVL 451
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
D N FI + EM+LK+++LG +GY N FD + + +
Sbjct 452 ATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVI-GSI 510
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
E+ + + G +L + + R ++ ++ + +++L
Sbjct 511 SEMVLTSSELMAPLGVS--------------VLRCVRLLRVFKVTKYWHSLSNLVASLLN 556
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN 634
+Q++ + +L + +F ++G+ +F G P + E +
Sbjct 557 SIQSIASLLLLLFLFIVIFGLLGMQVFGGRFTFKP------------------EEEKPRS 598
Query 635 NFDDFAAALVTLWNLMVVNNWQVFL-DAYRRYSGPWS-----KIYFVLWWLVSSVIWVNL 688
NFD F +L+T++ ++ +W V + D R Y G +S IY+++ ++ + I +N+
Sbjct 599 NFDSFYQSLLTVFQILTGEDWNVVMYDGIRAYGGVFSFGIVACIYYIILFICGNYILLNV 658
Query 689 FLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILE 731
FLA+ ++N + + + Q+ E+ + L+
Sbjct 659 FLAIAVDNLADADSLSTIEKEDESQIQLDNQIKNEMENEEYLQ 701
Score = 359 bits (921), Expect = 5e-106, Method: Composition-based stats.
Identities = 108/645 (17%), Positives = 230/645 (36%), Gaps = 76/645 (12%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ C R + + F L I S++ + + A + + VF
Sbjct 778 RFRIFCHRLCNHSNFGNFILCCIMFSSAMLAAENPLKADASRNI---VLNKFDYFFTAVF 834
Query 137 AADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCH-EPLRIRRLLR 191
+L +K +G+ F ++ + L L+V+ VSL+ + + + + LR+ R+LR
Sbjct 835 TIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISIFFNSNAISVVKILRVLRVLR 894
Query 192 PFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRER 251
P + + +K ++C+ ++ + ++ L+ + +F + G+ LF G D +
Sbjct 895 PLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFS-CSDGSK 953
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
+ L N D+ P + F V +LT
Sbjct 954 VYESDCHGTYL--------FYENGDINKPRLKEREWKNNKFHFDDV-----AKAMLTLFT 1000
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
S F G+ L S+ + + + + + ++ + +
Sbjct 1001 VSTFEGWPT-LLYVSIDS---NKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI 1056
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGH 431
+ + E Y + L + + L V+ + P + +
Sbjct 1057 VTFQNEGEQE----YKNCELDKNQRNCIEFALKAKPVRRYIP----KHSIQYKVWWFVTS 1108
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
F+Y ++ + N V++ + + IL LN +F + LE + K+ A
Sbjct 1109 SSFEYSIFVLIMINTVTLAMKFYKQPEYYSE-----ILDALNMIFTAVFSLEFIFKLAAF 1163
Query 492 GLRGYLSYPSNVFDGLLT----VVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ Y N FD ++ + ++ EI T G S
Sbjct 1164 RFKNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFF 1223
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G I+
Sbjct 1224 RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKIML 1282
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------- 659
G S NNF F A++ L+ WQ +
Sbjct 1283 EEGTS-----------------IDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDD 1325
Query 660 -------DAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
DA + YF+ ++++ S + +NLF+A+I++NF
Sbjct 1326 VKCDPESDAVNNCGSSIAFPYFISFYVLCSFLIINLFVAVIMDNF 1370
Score = 346 bits (888), Expect = 2e-101, Method: Composition-based stats.
Identities = 140/763 (18%), Positives = 285/763 (37%), Gaps = 88/763 (12%)
Query 8 SEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQA--VVFIEDAIQYRSINHR 65
+ + G DW +T I+ P A D ++ VV I++ + + +
Sbjct 348 EKQQIEEDLRGYLDW---ITQAEDIEPDPDAQIIEDCHKNKVKEVVSIDNLKDHENETQQ 404
Query 66 VDA----SSMWLYR--RYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAP 117
D+ +L R R C++ + +LI+ L F+ T T YR
Sbjct 405 TDSWFRSQKKYLERINRRIRRACRKAVKSQAFYWLIILLVFLNTGVLAT----EHYRQPI 460
Query 118 WEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS 177
W E + + +F ++ +K Y G+ + +L+ V++ S+ + ++ S
Sbjct 461 WLD--QFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIGSISEMVLTSS 518
Query 178 ----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+ LR RLLR F + + + + + S+ +AS+ LLL + + +F +
Sbjct 519 ELMAPLGVSVLRCVRLLRVFKVTKYWHSLSNLVASLLNSIQSIASLLLLLFLFIVIFGLL 578
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA-------YSKNR 286
GM +F G ++ + + F + +SL ++ +LT + VM +S
Sbjct 579 GMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVMYDGIRAYGGVFSFGI 638
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQF--RGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
I++I+ + G+ L+N+ AI L + + +L + E+ +
Sbjct 639 VACIYYIILFICGNYILLNVFLAIAVDNLADADSLSTIEKEDESQIQLDNQIKNEMENEE 698
Query 345 VGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELD 404
+ G +L LQ + S +S+ + ++D
Sbjct 699 YLQNGDHISFKAEFGADLDTYLQDEECGSYSDDENTYNKLGGVKQRVSSLPRRNTNTDMD 758
Query 405 RSVVKEHPPRP------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDAD 458
R +K+ P + + F L H F GN I + S + L +
Sbjct 759 R--IKKDIPYGTSFFIFSHTNRFRIFCHRLCNHSNF---GNFILCCIMFSSAM-LAAENP 812
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLV 514
+ + +L + F + +E++LK+ + G + N+ D L+ V L+
Sbjct 813 LKADASRNIVLNKFDYFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLI 872
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
+ + + ++L +L V R LR I K + V V+
Sbjct 873 ------------------SIFFNSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIV 914
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE------- 627
V+ + + ++ ++FA+IG+ LF+G + S + ++ +E
Sbjct 915 AVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFSCSDGSKVYESDCHGTYLFYENGDINKP 974
Query 628 --QLEYWANN---FDDFAAALVTLWNLMVVNNWQVFL----DAYRRYSGPWSKIYFVL-- 676
+ W NN FDD A A++TL+ + W L D+ + GP ++
Sbjct 975 RLKEREWKNNKFHFDDVAKAMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAA 1034
Query 677 ----WWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE 715
+ ++ + VN+F+ ++ F ++ + L
Sbjct 1035 YYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQR 1077
Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats.
Identities = 65/349 (19%), Positives = 128/349 (37%), Gaps = 50/349 (14%)
Query 405 RSVVKEHPPRPEY-------QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA 457
R K+ RPE ++P + F+Y L AN V++ V+
Sbjct 27 RRGGKQQLDRPERALFCLTLKNPLRIFCIKIVDSKLFEYFILLTIFANCVALAVYT--PY 84
Query 458 DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLL 513
+ + +L + +F+V + E ++K+ A G YL N D + V+ +
Sbjct 85 PSGDSNITNQMLEKIEYIFLVIFTSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGM 144
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+ + L+ + L V R LR++ + + VV +++L
Sbjct 145 I----------------STALSNLVKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIL 188
Query 574 GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS-----------------LAP 616
+ + +++ V ++AIIG+ LF G + +S+
Sbjct 189 KAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTCRHSNTGEYLNDLDELHACGVGFKC 248
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG-PWSKIYFV 675
+G + NFD+F +++T++ + + W L + + G W IYFV
Sbjct 249 PSGYECFDDWVGPNDGITNFDNFGLSMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFV 308
Query 676 LWWLVSSVIWVNLFLALILENFLH---KWDPRSHLQPLAGTPEATYQMT 721
++ + +NL L ++ F K R Q L + +
Sbjct 309 SMVILGAFFVMNLILGVLSGEFSKERTKAKNRGDFQKLREKQQIEEDLR 357
Score = 111 bits (277), Expect = 1e-23, Method: Composition-based stats.
Identities = 44/285 (15%), Positives = 103/285 (36%), Gaps = 48/285 (17%)
Query 70 SMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVE 129
+ + + V + ++IF+++ + + Y+ E + +++
Sbjct 1095 KHSIQYKVWWFVTSSSFEYSIFVLIMINTVTLAMKF-------YKQP--EYYSEILDALN 1145
Query 130 VLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV--------------- 174
++ VF+ + K F + ++ + W ++++ S +D
Sbjct 1146 MIFTAVFSLEFIFKLAAFRFKNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDG 1205
Query 175 --------SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
+L+ R+ R++R LL ++ L S + V LL+ +
Sbjct 1206 QSCNKAKGGSTLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVML 1265
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
++ + GM +F ++G +R FQ P+++ L T ++M+ ++
Sbjct 1266 FFIYAVIGMQVFGKIMLEEGTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDD 1325
Query 287 AYAI----------------FFIVFTVIGSLFLMNLLTAIIYSQF 315
+FI F V+ S ++NL A+I F
Sbjct 1326 VKCDPESDAVNNCGSSIAFPYFISFYVLCSFLIINLFVAVIMDNF 1370
>sp|Q05973|SCN1_HETBL Sodium channel protein 1 brain OS=Heterololigo
bleekeri OX=1423826 PE=2 SV=1
Length=1522
Score = 357 bits (915), Expect = 1e-105, Method: Composition-based stats.
Identities = 118/678 (17%), Positives = 232/678 (34%), Gaps = 99/678 (15%)
Query 67 DASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTE 126
D +S + F L I S L + D+ P
Sbjct 760 DDTSHGKKWNNFRRQLMMVCENKYFETGVLVIIFASSILLAFEDIYLNEKPRLKLA--IF 817
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS----LSLVCHE 182
+++ L+F ++ +K G+ H+ + W + +++++++ S +
Sbjct 818 YLDITFCLLFFLEMVLKLVALGFVHYYTHFWTILDFTIVIITVISLAASGLGMEQITAFR 877
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
LR R LRP + MK + + S+P + +V L+ + +F + G+ LFAG
Sbjct 878 SLRTLRALRPLRAVSRWQGMKIIVNALMLSIPSIFNVLLVCVVFWLIFAIMGVQLFAGK- 936
Query 243 QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLF 302
F + AN + Y+KN + + F +G F
Sbjct 937 ------------FYKCVNETNMRIPPTEVANKIEC----YNKNYTWVNSNVNFDNVGGAF 980
Query 303 LMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL 362
L A F G+ M+ + ++ + + FE F + +
Sbjct 981 LALFQVA----TFEGW-MEIMADAVDVTEVDEQPKFEATVY---YYFYFVLFIIFGSFFV 1032
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L ++ V +D + +K + Q +N L + K+ P+ + P
Sbjct 1033 LNLVIGVIIDKFSF--LKKKYDGTYLDMFLTPTQQNYYNTLKKLGTKK--PQKTVKRPKN 1088
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+ ++ + I + + + +E +L N F + Y +
Sbjct 1089 KCQAVVYDLVMSNQFEIFITTIIIT--NMIFMAFEHYNQSEVVTEVLATANIAFTILYAV 1146
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
E ++K+ L + YL NVFD L+ + ++ G+
Sbjct 1147 EAIIKIIGLRI-HYLRNLWNVFDFLVVTLSVMDAFLNDIFGD-----------GIFMNPS 1194
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
+ R+ M + R +R+I K M + ++ + + G +L++V +++ IIG++ F
Sbjct 1195 LLRVARMFRIGRIIRLIKWAKGMRKLLFALVISLPALFNIGALLMLVMFIYTIIGMSSFG 1254
Query 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA- 661
+ ++ N + NF F + L L W L
Sbjct 1255 QIKLSGALNDQV--------------------NFQTFGKTFLLLVRLATSAGWNDILGPL 1294
Query 662 -----------YRRYSG------------PWSKI-YFVLWWLVSSVIWVNLFLALILENF 697
+G PW I Y V + ++ +I N+++A+ILENF
Sbjct 1295 LIQPPNCDPNYITTSTGEKIKVVNGDCGMPWLAISYMVSYIIIVFMIVFNMYIAVILENF 1354
Query 698 LHKWDPRSHLQPLAGTPE 715
++H Q G E
Sbjct 1355 -----NQAHAQEEVGITE 1367
Score = 271 bits (694), Expect = 4e-76, Method: Composition-based stats.
Identities = 115/704 (16%), Positives = 244/704 (35%), Gaps = 79/704 (11%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
+ ++ + F +F+ FI +++ + + + + +
Sbjct 397 WLRVQSFAHCIITDS-FTEVFIIFIIVLNTVFLAMEHHGMSMELKNVLKVA---NYVFTT 452
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
VF + +K F + K+ W + LVV+V SL+D V L R RLLR F
Sbjct 453 VFVLEAILKLLAFN-KQYFKSGWNICDLVVVVASLIDLGVE-GLKGVSVFRSFRLLRVFH 510
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF--AGGKQDDGQDRERL 252
L Q+ + M+ L I +L + + ++L I + +F + G+ LF +
Sbjct 511 LAQSWTTMRLLLCIILNTLGSLGYLTIILIIVIYIFAVTGLQLFHTEYTPDKFRGEPVPR 570
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
F + S + +L + M + + L L ++
Sbjct 571 WNFNDFLHSFMMVFRILCGE-WIEPMYDCMRACNGLCFLIFIPVTVFGKTLFFLFIGLVL 629
Query 313 SQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLD 372
F G + + L + G + Q ++ ++D
Sbjct 630 GAF-GSDTVEQEVEVSSFALPGPESKPCSVRERGISATDDNVKDDGQDEVQQNSEETKID 688
Query 373 SSHKQAMMEK----VRSYGSVLLSA----------EEFQKLFNELDRSVVKEHPP----- 413
+ + + + L++ + + +++ K+ P
Sbjct 689 LRNNDKQSKDGMILENNCNNDSLASLGSLGSIPDIMDGSSVEDDISSCQQKDIQPCLPLF 748
Query 414 ---------------RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDAD 458
+ + F + + + YF+ +I A+ + + D
Sbjct 749 ISSRFKCLREFDDTSHGKKWNNFRRQLMMVCENKYFETGVLVIIFASSILLAFE---DIY 805
Query 459 VLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIS 518
+ R + L+ F + + LEM+LK+ ALG Y ++ + D + ++ ++
Sbjct 806 LNEKPRLKLAIFYLDITFCLLFFLEMVLKLVALGFVHYYTHFWTILDFTIVIITVI---- 861
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
L G E + R L L R LR + + M ++ + ++ + +
Sbjct 862 -----SLAASGLGMEQIT------AFRSLRTLRALRPLRAVSRWQGMKIIVNALMLSIPS 910
Query 579 MRAFGGILVVVYYVFAIIGINLFRGVIVAL--PGNSSLAPANGSAPCGSFEQLEYWAN-- 634
+ + VV + +FAI+G+ LF G N + P + + + W N
Sbjct 911 IFNVLLVCVVFWLIFAIMGVQLFAGKFYKCVNETNMRIPPTEVANKIECYNKNYTWVNSN 970
Query 635 -NFDDFAAALVTLWNLMVVNNWQVFL----------DAYRRYSGPWSKIYFVLWWLVSSV 683
NFD+ A + L+ + W + + + + + YFVL+ + S
Sbjct 971 VNFDNVGGAFLALFQVATFEGWMEIMADAVDVTEVDEQPKFEATVYYYFYFVLFIIFGSF 1030
Query 684 IWVNLFLALILE--NFLHKWDPRSHLQPLAGTPEATYQMTVELL 725
+NL + +I++ +FL K ++L + Y T++ L
Sbjct 1031 FVLNLVIGVIIDKFSFLKKKYDGTYLDMFLTPTQQNYYNTLKKL 1074
Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats.
Identities = 108/739 (15%), Positives = 239/739 (32%), Gaps = 106/739 (14%)
Query 47 DQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLT 106
D+ V IE + ++I HR A L+ N +R L+ I + + + +
Sbjct 11 DKTFVVIEKRFK-KNIIHRFSA-KRSLFLFTPRNPIRR-LAVCIATNVCFDYFLMFTIMI 67
Query 107 STADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW----AHFQKNLWLLGYL 162
+ + ++E E + L ++ ++++K G+ + ++ W
Sbjct 68 NCV--------FLAMPDISEFAEYIFLGIYTMEMAIKLVAGGFFIDKYTYLRDAWNCLDF 119
Query 163 VVLVVSLVDWTVSL----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMAS 218
V+++S + + + LR R+LR L +K + + +L + S
Sbjct 120 TVIMISYITLLLQTINDKVISDITGLRTFRVLRALRTLSIIPGLKTMVNALLRALRMLIS 179
Query 219 VGLLLAIHLCLFTMFGMLLFAG----------------GKQDDGQDRERLTYFQN---LP 259
V +L+ L +F+ G+ LF G GK D E + N
Sbjct 180 VLILILFCLWIFSQAGVQLFGGALRHKCVLQIHGSPAFGKTYDEFYAEHIENSDNWLAKG 239
Query 260 ESLTSLLVLLTTANNPDVMIPAYSKNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQFRGY 318
L T A + + F IG L++ +
Sbjct 240 NGEYVLCGNATGAGPCPTNYTCLPDIGENPNYGYTNFDSIGWSMLISFQLLTQ-DYWEDV 298
Query 319 LMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ--------AVGVKPQNLLQVLQKVQ 370
K ++ + ++ G+ A + + + Q
Sbjct 299 YNKVIRAHS--------PWTVIYFIVINFFGSLYLMNLMLAVVATAYELEVKNTGKKLQQ 350
Query 371 LDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG 430
++ ++ +++ ++ +S + + A +
Sbjct 351 TAATAREQSLKEQERRNTLTVSEADSHVDDRNCTCCEQCCGCCYNPWLR-VQSFAHCIIT 409
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
+ + I + N VFL ++ + E + +L + N VF ++LE +LK+ A
Sbjct 410 DSFTEVFIIFIIVLNT----VFLAMEHHGMSMELKN-VLKVANYVFTTVFVLEAILKLLA 464
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
+ Y N+ D ++ V L+ + +
Sbjct 465 FN-KQYFKSGWNICDLVVVVASLIDL--------------------GVEGLKGVSVFRSF 503
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPG 610
+ R + S M ++ +L + ++ IL++V Y+FA+ G+ LF
Sbjct 504 RLLRVFHLAQSWTTMRLLLCIILNTLGSLGYLTIILIIVIYIFAVTGLQLF--------- 554
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWS 670
+ F NF+DF + + ++ ++ W + R
Sbjct 555 -------HTEYTPDKFRGEPVPRWNFNDFLHSFMMVFRILCGE-WIEPMYDCMRACNGLC 606
Query 671 KIYFVLWWLVSSVIWVNLFLALILENF---LHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
+ F+ + ++ LF+ L+L F + + L G + +
Sbjct 607 FLIFIPVTVFGKTLFF-LFIGLVLGAFGSDTVEQEVEVSSFALPGPESKPCSVRERGISA 665
Query 728 --DILEEPGEDELTERLSQ 744
D +++ G+DE+ + +
Sbjct 666 TDDNVKDDGQDEVQQNSEE 684
>sp|P54282|CAC1A_RAT Voltage-dependent P/Q-type calcium channel
subunit alpha-1A OS=Rattus norvegicus OX=10116 GN=Cacna1a
PE=1 SV=1
Length=2212
Score = 359 bits (920), Expect = 2e-105, Method: Composition-based stats.
Identities = 113/648 (17%), Positives = 232/648 (36%), Gaps = 110/648 (17%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWL-LGYLVVLVVSLVDWTV 174
P + E + +F + +K G+ F + +N W + ++VVL L
Sbjct 130 PMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT 189
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G
Sbjct 190 EFDL---RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIG 246
Query 235 MLLFAGGKQDDGQDR------------------------------------ERLTYFQNL 258
+ + G + +T F N+
Sbjct 247 LEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNI 306
Query 259 PESLTSLLVLLTTANNPDVMIPAY--SKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ ++ +T D++ + S N ++FI +IGS F++NL+ ++ +F
Sbjct 307 LFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 366
Query 317 GYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK-PQNLLQVLQKVQLDSSH 375
+ F + R ++ + G +A V ++ V Q+ D +
Sbjct 367 KERERVENRRAFLK---LRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGAL 423
Query 376 KQAMMEKVRSYGSVLLSAEEF----QKLFNELDRSVVKEHPPRPE-----YQSPFLQSAQ 426
++A ++K ++ AE+ + + R+ +K + +
Sbjct 424 RRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIR 483
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
+ F + + N + + + E L +F+ ++ EM +
Sbjct 484 RMVKTQAFYWTVLSLVALNTLWLAI-----VHYNQPEWLSDFLYYAEFIFLGLFMSEMFI 538
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K++ LG R Y N FD ++ + E+ + +
Sbjct 539 KMYGLGTRPYFHSSFNCFDC-GVIIGSIFEVIWAVIKPG-----------------TSFG 580
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRG 603
+++L R LRI K A + + V+ L+ +M+ + +L + VFA++G+ LF G
Sbjct 581 ISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG 640
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD--- 660
G NFD F AA++T++ ++ +W +
Sbjct 641 QFNFDEGTP--------------------PTNFDTFPAAIMTVFQILTGEDWNEVMYDEI 680
Query 661 --AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
G IYF++ L + +N+FLA+ ++N + +
Sbjct 681 KSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 728
Score = 342 bits (876), Expect = 1e-99, Method: Composition-based stats.
Identities = 97/644 (15%), Positives = 217/644 (34%), Gaps = 84/644 (13%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+C L+ F + L I S + D P P + + + VF
Sbjct 1185 RRLCHYILNLRYFEMCILMVIAMSSIALAAEDPV---QPNAPRNNVLRYFDYVFTGVFTF 1241
Query 139 DLSVKG----YLFGWAHFQKNLWLLGYLVVLVVSLVDW-----TVSLSLVCHEPLRIRRL 189
++ +K + + ++LW + +V+ +LV + + + + LR+ R+
Sbjct 1242 EMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRV 1301
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDR 249
LRP ++ +K C+ SL + ++ ++ + + +F + + LF G D
Sbjct 1302 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFH-CTDE 1360
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
+ + L + + + N +A L+ L T
Sbjct 1361 SKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWA-------------LLTLFTV 1407
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
+ L S+ + + + V P + + +
Sbjct 1408 STGEGWPQVLKHSVDATF-------ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVAL 1460
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + +Q S E+ ++ + S P+ + F
Sbjct 1461 IIITFQEQGDKMMEE------YSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFV 1514
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F+Y + N + + + + L + N VF + LE +LKV
Sbjct 1515 VSPPFEYTIMAMIALNTIVLMMKFYGASVAYEN-----ALRVFNIVFTSLFSLECVLKVM 1569
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A G+ Y N+FD + + + + T + + L +
Sbjct 1570 AFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF----------------LRL 1613
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R ++++ + ++ T + + + ++ ++++++AIIG+ +F
Sbjct 1614 FRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG------- 1666
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY------- 662
N + + + F+ E+ NNF F AL+ L+ W + +
Sbjct 1667 -NIGIDGEDEDSDEDEFQITEH--NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCD 1723
Query 663 -------RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
++ YFV + + S + +NLF+A+I++NF +
Sbjct 1724 KNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1767
Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats.
Identities = 55/315 (17%), Positives = 113/315 (36%), Gaps = 43/315 (14%)
Query 379 MMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ--------SPFLQSAQFLFG 430
+++ ++ L +E +K E P P Y +P + ++
Sbjct 1134 VVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILN 1193
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ ++ + ++ L + V P + +L + VF + EM++K+
Sbjct 1194 LRYFEMCILMVIAMSSIA----LAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMID 1249
Query 491 LGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
LGL Y N+ D ++ LV + + +
Sbjct 1250 LGLVLHQGAYFRDLWNILDFIVVSGALV--------------AFAFTGNSKGKDINTIKS 1295
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + ++ ++FA++ + LF+G
Sbjct 1296 LRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFF 1355
Query 607 ALPGNSSLAPANGSAPCGSFEQLE---------YWANNFDDFAAALVTLWNLMVVNNWQV 657
S + +E+ E + ++D+ AL+TL+ + W
Sbjct 1356 HCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQ 1415
Query 658 FL----DAYRRYSGP 668
L DA GP
Sbjct 1416 VLKHSVDATFENQGP 1430
Score = 163 bits (413), Expect = 3e-40, Method: Composition-based stats.
Identities = 58/345 (17%), Positives = 119/345 (34%), Gaps = 46/345 (13%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + A+ + F+Y+ +AN + + + L D + L FI
Sbjct 87 NVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER--LDDTEPYFIG 144
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ E +K+ ALG YL NV D ++ + ++ + T
Sbjct 145 IFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGT--------------- 189
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
R L + V R L+++ + + VV +++ + + G +L +FA
Sbjct 190 ------EFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFA 243
Query 595 IIGINLFRGVIVALP------------------GNSSLAPANGSAPCGSFEQLEYWANNF 636
IIG+ + G + NG+ +E F
Sbjct 244 IIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQF 303
Query 637 DDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILE 695
D+ A++T++ + + W L SG W+ +YF+ ++ S +NL L ++
Sbjct 304 DNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSG 363
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
F + + + + + + + + E L E
Sbjct 364 EFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAE 408
Score = 145 bits (365), Expect = 3e-34, Method: Composition-based stats.
Identities = 73/368 (20%), Positives = 136/368 (37%), Gaps = 28/368 (8%)
Query 71 MWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
R +R + + +L L + T A V Y W
Sbjct 471 FHKKERRMRFYIRRMVKTQAFYWTVLSLVALNT----LWLAIVHYNQPEWLSD--FLYYA 524
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLVC---HEPL 184
E + L +F +++ +K Y G + + + V++ S+ + + L
Sbjct 525 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVL 584
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R RLLR F + + + ++ + + S+ + S+ LL + + +F + GM LF G Q
Sbjct 585 RALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG--QF 642
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN------RAYAIFFIVFTVI 298
+ + T F P ++ ++ +LT + +VM ++I+FIV T+
Sbjct 643 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIKSQGGVQGGMVFSIYFIVLTLF 702
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQ----TSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
G+ L+N+ AI + ++L + A EV V A +
Sbjct 703 GNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAE--VSPLSAANMS 760
Query 355 VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLL--SAEEFQKLFNELDRSVVKEHP 412
+ VK Q Q K + + + + + L +AE + + R VK H
Sbjct 761 IAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKTHL 820
Query 413 PRPEYQSP 420
RP P
Sbjct 821 DRPLVVDP 828
Score = 120 bits (302), Expect = 1e-26, Method: Composition-based stats.
Identities = 54/296 (18%), Positives = 103/296 (35%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V +TI ++ L I A V
Sbjct 1486 IDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVL-MMKFYGASVA 1544
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y A ++ +F+ + +K FG ++ ++ W + V ++ S+ D
Sbjct 1545 YENALRV--------FNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDI 1596
Query 173 TV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V + + LR+ R R LL+ ++ L S + V LL+A+ +
Sbjct 1597 LVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1656
Query 230 FTMFGMLLFA--------GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
+ + GM +F +D F+ ++L L T ++M+
Sbjct 1657 YAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSC 1716
Query 282 YSK---------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
S N +F+ F + S ++NL A+I F S
Sbjct 1717 LSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1772
>sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus
musculus OX=10090 GN=Tpcn1 PE=1 SV=1
Length=817
Score = 342 bits (877), Expect = 1e-104, Method: Composition-based stats.
Identities = 158/666 (24%), Positives = 278/666 (42%), Gaps = 60/666 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV----EVLCLLVFAAD 139
R L+ +F+ ++ + + +P P L V E+ L+V +
Sbjct 96 RALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPVLKLHTYVHATLELFALMVVVFE 155
Query 140 LSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL--Q 197
L +K G+ F ++ + VLVV ++ V L R+ R LR FL+ +
Sbjct 156 LCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHV-RVTRALRCIFLVDCR 214
Query 198 NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQN 257
+++ L+ I SLP + LLL + +F + G LF+ D YF
Sbjct 215 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDP--------YFST 266
Query 258 LPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
L S+ +L VLLTTAN PDVM+P+YS+N +FFIV+ I F+MNLL A+++ F
Sbjct 267 LENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 326
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQ 377
++ L +R + A+ +L+S G + + L K ++ + +
Sbjct 327 IEKHKFKSLLLHKRTAIQHAYGLLASQRRPAG-----ISYRQFEGLMRFYKPRMSARERF 381
Query 378 AMMEKVRSYGSVLLSAEEFQKLFN--------ELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + + LLS ++F ++ + +R + PR + + L
Sbjct 382 LTFKALNQSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFL--IFKGINILV 439
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
F Y L+ N V I V + + + VF+ Y +E+ +KV
Sbjct 440 NSKAFQYFMYLVVAVNGVWILVETFMLKGGNFTSKH---VPWSYLVFLTIYGVELFMKVA 496
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
LG YLS N+FD +T + ++ + + +
Sbjct 497 GLGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFY------------------FIVV 538
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
L + LR+ K V T+ L+ M + G L+ YY FAI+G+ F G +
Sbjct 539 LRPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFYYSFAIVGMEFFNGRLTPNC 598
Query 610 GNSSLAPA------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
N+S + E+ Y+ NNFD+ + VTL+ L VVNNW + ++
Sbjct 599 CNTSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVT 658
Query 664 RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ--PLAGTPEATYQMT 721
+ WS++YF+ +++V+ ++ + + +A ILE F+ + + Q + +M+
Sbjct 659 SQTSHWSRLYFMTFYIVT-MVVMTIIVAFILEAFVFRMNYSRKSQDSEVDSGIVIEKEMS 717
Query 722 VELLFR 727
E L
Sbjct 718 KEELMA 723
>sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Hordeum
vulgare OX=4513 GN=TPC1 PE=2 SV=1
Length=742
Score = 339 bits (868), Expect = 4e-104, Method: Composition-based stats.
Identities = 180/753 (24%), Positives = 313/753 (42%), Gaps = 75/753 (10%)
Query 14 GARGGGGDWPAGLTTYRSIQVGPG-----AAARWDLCIDQAVVFIEDAIQYRSINHRVDA 68
GGG + RS + G AAA DL D + + R
Sbjct 25 RLSDGGGGQGSRKYRRRSDALAHGDRYQKAAALVDLAEDGVGIPEDVLNDTR-------- 76
Query 69 SSMWLYRRYYSNVCQ--RTLSFTIFLILFLAFIETP-----SSLTSTADVRYRAAPWEPP 121
+Y + S IF ++ L F+E P +L + P
Sbjct 77 --FGRAMSFYFVYLRLDWLWSLNIFALILLNFLEKPLWCRKDALHACDQRDMYFLGQLPY 134
Query 122 CGLTESV--EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV 179
TES+ E L L++ ++ G F ++ +++L + D V
Sbjct 135 FSKTESLIYEGLTLVILVMEILCPLSYEGLNIFWRSTTNKLKILLLFILACDILVF--AF 192
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+P R+ +R FL+ ++ + + +V L + L + + F
Sbjct 193 SSQPFRLAPYIRVVFLIMTIRELRMCAITLAGLIGTYLNVLALSLLFLLFASWLAYVTFE 252
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ T F + +L + VL TT+NNPDV +PAY +R Y++FFIV+ ++G
Sbjct 253 -------DTPQGKTIFSSYGVTLYQMFVLFTTSNNPDVWVPAYKISRWYSLFFIVYVLLG 305
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
FL NL+ A+IY F+ K L R+ + AFE++ + G + +
Sbjct 306 VYFLTNLILAVIYDSFKEQFAKQLVQVDAIRKNILQKAFELIDT--NTRGYLDREQCISL 363
Query 360 QNLLQVLQK-VQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR---- 414
N L + + + + ++ G +++EEF L N + KE PP
Sbjct 364 LNELNKYRSLPKTSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEK 423
Query 415 -PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
P Y SP + F+Y+ + L NLV++ + LD + ++ +
Sbjct 424 FPFYHSPVCGRLKSFVRSRTFEYIIVFVLLINLVAVIIETTLDIENSSSQET---WQEVE 480
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
Y+ EM LK+F+LG Y N FD +LT + + E T A P
Sbjct 481 FFLGWIYVAEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAF---------PS 531
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
+ LS + R L + V R RI+ ++ V +T L+ ++ + GI+ + ++
Sbjct 532 KLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRVFVATFFTLMSSLMPYLGIVFCILCMY 591
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
+G+ +F G++ A GN +L + + +Y NF+D+ + +VTL+NL+V+
Sbjct 592 CSLGLQIFGGIVYA--GNPTLEETDLFSN-------DYLLFNFNDYPSGMVTLFNLLVMG 642
Query 654 NWQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF-----LHKWDPRSHL 707
NWQV++++Y + +G WS IYFV ++L+S ++ +NL +A +LE F L K +
Sbjct 643 NWQVWMESYWQLTGSSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQ 702
Query 708 QPLAGTPEATYQMTVE-------LLFRDILEEP 733
P +G + M V +L +L
Sbjct 703 SPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNE 735
>sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus
norvegicus OX=10116 GN=Tpcn1 PE=1 SV=2
Length=817
Score = 340 bits (873), Expect = 4e-104, Method: Composition-based stats.
Identities = 160/665 (24%), Positives = 275/665 (41%), Gaps = 58/665 (9%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV----EVLCLLVFAAD 139
R L+ +F+ ++ + + +P P L V E+ L+V +
Sbjct 96 RALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPALKLRTYVHATLELFALMVVVFE 155
Query 140 LSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL--Q 197
L +K G+ F ++ + VLVV ++ V L R+ R LR FL+ +
Sbjct 156 LCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHV-RVTRALRCIFLVDCR 214
Query 198 NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQN 257
+++ L+ I SLP + LLL + +F + G LF+ D YF
Sbjct 215 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDP--------YFNT 266
Query 258 LPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
L S+ +L VLLTTAN PDVM+P+YS+N +FFIV+ I F+MNLL A+++ F
Sbjct 267 LENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 326
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQ 377
++ L +R + A+ +L S G + + L K ++ + +
Sbjct 327 IEKHKFKSLLLHKRTAIQHAYHLLVSQRRPAG-----ISYRQFEGLMRFYKPRMSARERF 381
Query 378 AMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR-------PEYQSPFLQSAQFLFG 430
+ + + LLS ++F ++ E+ K R P + L
Sbjct 382 LTFKALNQSNTPLLSLKDFYDIY-EVAALQWKAKKNRQHWFDELPRTAFLIFKGINILVN 440
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
F Y L+ N V I V + + + VF+ Y +E+ +KV
Sbjct 441 SKAFQYFMYLVVAVNGVWILVETFMLKGGNFISKH---VPWSYLVFLTIYGVELFMKVAG 497
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNML 550
LG YLS N+FD +T + ++ + + +L
Sbjct 498 LGPVEYLSSGWNLFDFSVTAFAFLGLLALTLNMEPFY------------------FIVVL 539
Query 551 IVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPG 610
+ LR+ K V T+ L+ M + G L+ YY FAI+G+ F G +
Sbjct 540 RPLQLLRLFKLKKRYRNVLDTMFELLPRMASLGLTLLTFYYSFAIVGMEFFSGRLSPNCC 599
Query 611 NSSLAPA------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR 664
NSS + E+ Y+ NNFD+ + VTL+ L VVNNW + ++
Sbjct 600 NSSTVADAYRFINHTVGNKTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTS 659
Query 665 YSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ--PLAGTPEATYQMTV 722
+ WS++YF+ +++V+ ++ + + +A ILE F+ + + Q + +M+
Sbjct 660 QTSHWSRLYFMTFYIVT-MVVMTIIVAFILEAFVFRMNYSRKSQESEVDSGIVIEKEMSK 718
Query 723 ELLFR 727
E L
Sbjct 719 EELLA 723
>sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza
sativa subsp. japonica OX=39947 GN=TPC1 PE=1 SV=2
Length=757
Score = 339 bits (868), Expect = 6e-104, Method: Composition-based stats.
Identities = 166/693 (24%), Positives = 301/693 (43%), Gaps = 57/693 (8%)
Query 38 AAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQ--RTLSFTIFLILF 95
AAA DL D + + R R+Y + S +F ++
Sbjct 66 AAALVDLAEDGVGIPEDVLNDTR----------FERAMRFYFVYLRLDWLWSLNLFALIL 115
Query 96 LAFIETP-----SSLTSTADVRYRAAPWEPPCGLTESV--EVLCLLVFAADLSVKGYLFG 148
L F+E P S + P TES+ E L L++ D+ G
Sbjct 116 LNFLEKPLWCRGYSQHACDQRDLYFLGQLPYLSKTESLIYEGLTLVILVMDIFYPLSYEG 175
Query 149 WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKC 208
F KN + L VL++ ++ + + +P R+ +R FL+ N ++
Sbjct 176 LNLFWKN--TINKLKVLLLFILACDILVFAFSPQPFRVAPYIRVAFLIMNIRELRMCAVT 233
Query 209 IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVL 268
+ + +V L + L + + F + T F + +L + +L
Sbjct 234 LVGMVGTYLNVLALSLLFLLFASWLAYVTFE-------DTPQGKTVFSSYGTTLYQMFIL 286
Query 269 LTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF 328
TT+NNPDV +PAY +R ++FFIV+ ++G FL NL+ A+IY F+ L K + +
Sbjct 287 FTTSNNPDVWVPAYKSSRWSSLFFIVYVLLGVYFLTNLILAVIYDSFKEQLAKQVSQADC 346
Query 329 RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGS 388
R+ AF ++ + G+G + L + + + + ++ G
Sbjct 347 TRKSILEKAFGIIDAT-GQGYLNKEQCLSLLDELNKYRSLPKTSREDFELIFAELDQSGD 405
Query 389 VLLSAEEFQKLFNELDRSVVKEHPPR------PEYQSPFLQSAQFLFGHYYFDYLGNLIA 442
+++EEF L N + KE PP Y S + + F+Y+ +
Sbjct 406 FKVTSEEFATLCNTIAIKFQKEPPPSYLEKYPSFYHSALCEWLKSFVRSPLFEYIVIFVL 465
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
L NLV++ + LD + +++ + + VF Y++EM LK+F+LG Y N
Sbjct 466 LMNLVAVIIETTLDIENSSSQK---VWQEVEFVFGWIYVIEMALKIFSLGFGAYWMEGQN 522
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
FD +LT + + E T A P + LS + R L + + R RI+ +
Sbjct 523 KFDFVLTWTIFIGETLTFAF---------PSKLSFLSNGEWIRYLLLGRMLRLTRILLQV 573
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
+ +T L+ ++ + GI+ ++ +G+ +F G++ A GN +L + +
Sbjct 574 RRFRAFVATFFTLMSSLMPYLGIVFCTLCIYCSLGLQIFGGIVYA--GNPTLEETDLFSN 631
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVS 681
+Y NF+D+ + +VTL+NL+V+ NWQ ++++YR+ +G WS IYFV ++L+S
Sbjct 632 -------DYLLFNFNDYPSGMVTLFNLLVMGNWQAWMESYRQLTGSYWSLIYFVSFYLIS 684
Query 682 SVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
++ +NL +A +LE F + + + P
Sbjct 685 VLLLLNLIVAFVLEAFFAEMELEKDGEADIQDP 717
>sp|Q02343|CAC1E_RABIT Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Oryctolagus cuniculus OX=9986 GN=CACNA1E
PE=2 SV=1
Length=2259
Score = 352 bits (904), Expect = 2e-103, Method: Composition-based stats.
Identities = 124/693 (18%), Positives = 244/693 (35%), Gaps = 109/693 (16%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ + + F + LA I + + P E E + +F
Sbjct 79 RKYAKKLIDWPPFEYMILATIIANCIVLALE-QHLPEDDKTPMSRRLEKTEPYFIGIFCF 137
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLV-VSLVDWTVSLSL-VCHEPLRIRRLLRP 192
+ +K G+ + +N W + +V++ L + V LR R+LRP
Sbjct 138 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 197
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG------ 246
L+ ++ LK I ++ + +GLLL + +F + G+ ++G
Sbjct 198 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFVNNSG 257
Query 247 --------------------------QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP 280
+ +T F N+ ++ ++ +T V+
Sbjct 258 VLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVL-- 315
Query 281 AYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
Y+ N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 316 -YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK---LR 371
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNL--------LQVLQKVQLDSSHKQAMMEKVRSYG 387
++ + G +A V L+VL++ + S +AM
Sbjct 372 RQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEH 431
Query 388 SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLV 447
V +S+ + + V + S + F ++ + N
Sbjct 432 CVDISSVGTPLARASIKSAKVDGASYFRHKERLLRISVRHAVKSQVFYWIVLSLVALNTA 491
Query 448 SICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
+ + + +L +F+ +LLEM LK++ +G R Y N FD
Sbjct 492 CVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFG 546
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+T V + E+ + +++L R LRI K A
Sbjct 547 VT-VGSIFEVVWAIFRPG-----------------TSFGISVLRALRLLRIFKITKYWAS 588
Query 568 VASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
+ + V+ L+ +M+ + +L + VFA++G+ LF G G S
Sbjct 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA---------- 638
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR-----YSGPWSKIYFVLWWL 679
NFD F AA++T++ ++ +W + R SG WS +YF++ L
Sbjct 639 ----------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAVYFIVLTL 688
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ +N+FLA+ ++N + + Q
Sbjct 689 FGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 721
Score = 330 bits (847), Expect = 8e-96, Method: Composition-based stats.
Identities = 107/653 (16%), Positives = 220/653 (34%), Gaps = 97/653 (15%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C ++ F + L I S + D + + + + VF
Sbjct 1132 IRRACHYVVNLRYFEMCILLVIAASSIALAAEDPVLTNSERN---RVLRYFDYVFTGVFT 1188
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--------HEPLR 185
++ +K G + ++LW + VV+V +LV + ++ +L + LR
Sbjct 1189 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1248
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1249 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY- 1307
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
D + T + + + + + N +A L+
Sbjct 1308 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWA-------------LLT 1354
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L T + L S+ + R E+ V FP L+ +
Sbjct 1355 LFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIII 1414
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ Q D ++ +EK E + + + + P+ + F
Sbjct 1415 TFQEQGDKMMEECSLEK-----------NERACIDFAISAKPLTRYMPQNRHT--FQYRV 1461
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + L LN F + + LE +
Sbjct 1462 WHFVVSPSFEYTIMAMIALNTVVLMM-----KYYSAPCTYELALKYLNIAFTMVFSLECV 1516
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LKV A G Y N+FD +TV+ + EI + G+
Sbjct 1517 LKVIAFGFVNYFRDTWNIFDF-ITVIGSITEIVLTDSKLVNTTGFNMSF----------- 1564
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1565 -LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI- 1622
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
E NNF F +L+ L+ WQ + +
Sbjct 1623 -----------------RLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE 1665
Query 666 SG-------------------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
G + +YFV + S + +NLF+A+I++NF +
Sbjct 1666 KGCEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1718
Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats.
Identities = 54/315 (17%), Positives = 106/315 (34%), Gaps = 44/315 (14%)
Query 383 VRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP------------EYQSPFLQSAQFLFG 430
+ E ++ E ++ KE P +P ++ ++
Sbjct 1082 KTDGEASPFQEAEMKEAEQETEKQKKKERPASGKAMVPHSSMFIFSTSNPIRRACHYVVN 1141
Query 431 HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA 490
YF+ L+ A+ + L + VL + +L + VF + EM++K+
Sbjct 1142 LRYFEMCILLVIAASS----IALAAEDPVLTNSERNRVLRYFDYVFTGVFTFEMVIKMID 1197
Query 491 LGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
GL Y N+ D V++V + A+ +
Sbjct 1198 QGLILQDGSYFRDLWNILDF----VVVVGALVAFALANALGTNKG-------RDIKTIKS 1246
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R L+ I + + V V+ ++N+ + + ++FA+I + LF+G
Sbjct 1247 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1306
Query 607 ALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
+S E + + ++D+ AL+TL+ + W
Sbjct 1307 YCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQ 1366
Query 658 FL----DAYRRYSGP 668
L D GP
Sbjct 1367 VLQHSVDVTEEDRGP 1381
Score = 167 bits (423), Expect = 2e-41, Method: Composition-based stats.
Identities = 59/348 (17%), Positives = 125/348 (36%), Gaps = 43/348 (12%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ L F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 76 NIVRKYAKKLIDWPPFEY----MILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYF 131
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D ++ + G
Sbjct 132 IGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL-----------------SGILA 174
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R L + V R L+++ + + +V +++ + + G +L +
Sbjct 175 TAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 234
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAP--------------CGSFEQLEYWANNFDD 638
FAIIG+ + G + ++ G P C + FD+
Sbjct 235 FAIIGLEFYSGKLHRACFVNNSGVLEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILENF 697
A++T++ + + W L G W+ +YF+ ++ S +NL L ++ F
Sbjct 295 ILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 354
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQH 745
+ + + + Q+ EL + E+ + +++
Sbjct 355 AKERERVENRRAFM-KLRRQQQIERELNGYRAWIDKAEEVMLAEENKN 401
Score = 138 bits (348), Expect = 4e-32, Method: Composition-based stats.
Identities = 62/347 (18%), Positives = 126/347 (36%), Gaps = 26/347 (7%)
Query 8 SEPLLGGARGGGGDWP------AGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
E +L G A + R+ + ++ + I + A
Sbjct 391 EEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARA---SI 447
Query 62 INHRVDASSMWLYRRYYSNVC-QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
+ +VD +S + ++ + + + +F + L+ + ++ + V + W
Sbjct 448 KSAKVDGASYFRHKERLLRISVRHAVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLT 505
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLV 179
L E L L +F ++S+K Y G + + + V V S+ +
Sbjct 506 H--LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPG 563
Query 180 C---HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
LR RLLR F + + + ++ + + S+ + S+ LL + + +F + GM
Sbjct 564 TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 623
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------AYSKNRAYAI 290
LF G + D F P ++ ++ +LT + +VM S A+
Sbjct 624 LFGGRF--NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAV 681
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
+FIV T+ G+ L+N+ AI + + A
Sbjct 682 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHA 728
Score = 128 bits (321), Expect = 7e-29, Method: Composition-based stats.
Identities = 51/296 (17%), Positives = 113/296 (38%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V + +TI ++ L + ++
Sbjct 1437 IDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLM--------MK 1488
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y +AP L + + + +VF+ + +K FG+ ++ ++ W + + ++ S+ +
Sbjct 1489 YYSAPCTYELAL-KYLNIAFTMVFSLECVLKVIAFGFVNYFRDTWNIFDFITVIGSITEI 1547
Query 173 TVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
++ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1548 VLTDSKLVNTTGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1607
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN- 285
++ + GM +F + D+ R F++ SL L T ++M+ +
Sbjct 1608 FFIYAIIGMQVFGNIRLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1667
Query 286 -------------------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
++F+ F S ++NL A+I F S
Sbjct 1668 CEPDTTAPSGQQESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDS 1723
>sp|C9D7C2|CAC1A_APIME Voltage-dependent calcium channel type
A subunit alpha-1 OS=Apis mellifera OX=7460 GN=CAC PE=2 SV=1
Length=1904
Score = 352 bits (903), Expect = 2e-103, Method: Composition-based stats.
Identities = 129/696 (19%), Positives = 256/696 (37%), Gaps = 91/696 (13%)
Query 70 SMWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
WL + + ++++ + ++ L F T A Y W
Sbjct 549 QFWLAEKRFRYWIRKSVKSQKFYWFVIVLVFFNT----VCVAVEHYGQPQWLTD--FLYF 602
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT---VSLSLVCHEPL 184
E + L +F ++ +K Y G + + + VV+ S+ + V L
Sbjct 603 AEFVFLALFMLEMFIKVYALGPRTYFDSSFNRFDCVVISGSIFEVIWSEVKSGSFGLSVL 662
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R RLLR F + + ++ + + S+ + S+ LL + + +F + GM LF G Q
Sbjct 663 RALRLLRIFKVTKYWKSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQLFGG--QF 720
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN------RAYAIFFIVFTVI 298
+ T F P +L ++ +LT + +VM Y+++FIV +
Sbjct 721 NFDSGTPPTNFNTFPIALLTVFQILTGEDWNEVMYQGIESQGGHKKGMIYSLYFIVLVLF 780
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK 358
G+ L+N+ AI A E+ ++ E Q +
Sbjct 781 GNYTLLNVFLAIAVDNLAN-------------------AQELSAAENEEEEEDKQKQAQE 821
Query 359 PQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPE-- 416
+ +Q LQ + + K +E G + E +K +E D + K P
Sbjct 822 IEKEIQSLQNPKDGGAPK---VEICPPNGKGGKQSSEEEKKQDEDDDTGPKPMLPYSSMF 878
Query 417 ---YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
+P ++A ++ YFD+ ++ + ++ L + V + +L +
Sbjct 879 ILSPTNPVRRAAHWVVNLRYFDFFIMVVISLSSIA----LAAEDPVWEDSPRNEVLNYFD 934
Query 474 CVFIVYYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
F + +EM+LK+ LG YL N+ D ++ + V +
Sbjct 935 YAFTGVFTVEMILKIIDLGIILHPGSYLREFWNIMDAVVVICAAVSFAFDMTGSSAGQ-- 992
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+ L +L V R L+ I + + V V+ ++N+ + ++
Sbjct 993 ----------NLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILF 1042
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE--------QLEYWANNF---DD 638
++FA+I + LF G S + FE + W + F D+
Sbjct 1043 QFIFAVIAVQLFNGKFFYCSDESKYTQQDCQGQYFVFEDGALLPEPKKREWQSQFFHYDN 1102
Query 639 FAAALVTLWNLMVVNNW----QVFLDAYRRYSGP------WSKIYFVLWWLVSSVIWVNL 688
AA++TL+ + W Q + A GP I+++++++V +VN+
Sbjct 1103 VMAAMLTLFAVQTGEGWPQILQNSMAATYEDKGPIQNFRIEMSIFYIVYFIVFPFFFVNI 1162
Query 689 FLALILENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
F+ALI+ F + + + G + + ++
Sbjct 1163 FVALIIITFQEQGEA----ELQDGEIDKNQKSCIDF 1194
Score = 336 bits (862), Expect = 6e-98, Method: Composition-based stats.
Identities = 93/644 (14%), Positives = 215/644 (33%), Gaps = 92/644 (14%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ F + I S + D + +P + + VF
Sbjct 887 RRAAHWVVNLRYFDFFIMVVISLSSIALAAEDPVWEDSPRN---EVLNYFDYAFTGVFTV 943
Query 139 DLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL-------SLVCHEPLRIR 187
++ +K G + + + W + VV++ + V + + +L + LR+
Sbjct 944 EMILKIIDLGIILHPGSYLREFWNIMDAVVVICAAVSFAFDMTGSSAGQNLSTIKSLRVL 1003
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+LRP ++ +K C+ SL + ++ ++ + +F + + LF G
Sbjct 1004 RVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAVQLFNGKFFY-CS 1062
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
D + T + D + K R + F + + + ++ L
Sbjct 1063 DESKYTQQDCQGQYFV----------FEDGALLPEPKKREWQSQFFHYDNVMAA-MLTLF 1111
Query 308 TAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
+ L S+ + + + + + V P + +
Sbjct 1112 AVQTGEGWPQILQNSMAAT-------YEDKGPIQNFRIEMSIFYIVYFIVFPFFFVNIFV 1164
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ + + +Q E ++ QK + P+ ++
Sbjct 1165 ALIIITFQEQGEAELQDGE------IDKNQKSCIDFTIQARPLERYMPKERNSVKYKIWR 1218
Query 428 LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ F+Y + + N V + + +D L +N F + +E +LK
Sbjct 1219 IVVSTPFEYFIMGLIVLNTVLLMMKFHRQSDAY-----KNTLKYMNMCFTGMFTVECILK 1273
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ A G+R + N FD + + +V + + G+ L
Sbjct 1274 IAAFGVRNFFKDAWNTFDFITVIGSIVDALVIEFGENFINVGF----------------L 1317
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
+ R ++++ + ++ T + + + ++ ++++++AIIG+ +F + +
Sbjct 1318 RLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1377
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD------- 660
+ + NNF F L+ L+ W +
Sbjct 1378 ADTSIT------------------KHNNFQSFIQGLMLLFRCATGEAWPNIMLSCVKGRP 1419
Query 661 ----AYRRYSGPWSKI---YFVLWWLVSSVIWVNLFLALILENF 697
A ++ G S I YFV + S + +NLF+A+I++NF
Sbjct 1420 CDAKAGKQEGGCGSNIAYAYFVSFIFFCSFLMLNLFVAVIMDNF 1463
Score = 318 bits (814), Expect = 1e-91, Method: Composition-based stats.
Identities = 116/669 (17%), Positives = 232/669 (35%), Gaps = 116/669 (17%)
Query 125 TESVEVLCLLVFAADLSVKGYLFGW----AHFQKNLWL-LGYLVVLVVSLVDWTVSLSL- 178
E+ E+ L +F + S+K G+ + +N+W + + VV+ + ++ + L
Sbjct 203 LEATEIYFLGIFCVEASLKILALGFVLHRGSYLRNIWNIMDFFVVVTGFITAFSQGIELD 262
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
+ LR R+LRP L+ ++ LK I ++ + +GLL+ + +F + G+ +
Sbjct 263 MDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFY 322
Query 239 AGGKQDDGQD----------------------------------------------RERL 252
+G +
Sbjct 323 SGTLHKTCYSIRDINVIVKEGEQASPCNTDNKSEAPFGAHVCDANISTCMDHWEGPNFGI 382
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-----YAIFFIVFTVIGSLFLMNLL 307
T F N+ ++ ++ +T ++ Y N A I+FI V+GS F++NL+
Sbjct 383 TSFDNIGFAMLTVFQCITMEGWTAIL---YWTNDALGSTYNWIYFIPLIVLGSFFMLNLV 439
Query 308 TAIIYSQFRGYLMKSLQTSLFRR-RLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
++ +F K F + R + E+ + A + + +
Sbjct 440 LGVLSGEFAKEREKVENRQSFLKLRRQQQLEHELYCYLNWICKAEEVILAEERTTEEEKK 499
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ---SPFLQ 423
++ + + +S + E + S KE P ++ F
Sbjct 500 HILEGRKRAEAKKKKLGKSKSTDTEEEEGDDDQDDGELSSSTKEKGPCKQFWLAEKRFRY 559
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ F + ++ N V + V L L VF+ ++LE
Sbjct 560 WIRKSVKSQKFYWFVIVLVFFNTVCVAVEHYGQPQWLTD-----FLYFAEFVFLALFMLE 614
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
M +KV+ALG R Y N FD + + + E+ V
Sbjct 615 MFIKVYALGPRTYFDSSFNRFDC-VVISGSIFEVIWSEVKSG------------------ 655
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINL 600
+ L++L R LRI K + + V+ L+ +MR + +L + +FA++G+ L
Sbjct 656 SFGLSVLRALRLLRIFKVTKYWKSLRNLVISLLSSMRSIISLLFLLFLFILIFALLGMQL 715
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F G G NF+ F AL+T++ ++ +W +
Sbjct 716 FGGQFNFDSGTP--------------------PTNFNTFPIALLTVFQILTGEDWNEVMY 755
Query 661 AYRRYS-----GPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE 715
G +YF++ L + +N+FLA+ ++N + + + +
Sbjct 756 QGIESQGGHKKGMIYSLYFIVLVLFGNYTLLNVFLAIAVDNLANAQELSAAENEEEEEDK 815
Query 716 ATYQMTVEL 724
+E
Sbjct 816 QKQAQEIEK 824
Score = 152 bits (384), Expect = 1e-36, Method: Composition-based stats.
Identities = 56/337 (17%), Positives = 118/337 (35%), Gaps = 56/337 (17%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCVF 476
+ + +F+ F+Y L +++ CV L L+ + ++ L F
Sbjct 155 NCIRKHTRFIIEWPPFEYA----VLLTIIANCVVLALEEHLPKQDKTILAQKLEATEIYF 210
Query 477 IVYYLLEMLLKVFALGLR----GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
+ + +E LK+ ALG YL N+ D + V + S
Sbjct 211 LGIFCVEASLKILALGFVLHRGSYLRNIWNIMDFFVVVTGFITAFS-------------- 256
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ L R L + V R L+++ + + VV +++ + + G +++ +
Sbjct 257 ---QGIELDMDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVI 313
Query 593 FAIIGINLFRG-----VIVALPGNSSLAPANGSAPCGSFEQ------------------- 628
FAIIG+ + G N + ++PC + +
Sbjct 314 FAIIGLEFYSGTLHKTCYSIRDINVIVKEGEQASPCNTDNKSEAPFGAHVCDANISTCMD 373
Query 629 ----LEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSV 683
+ +FD+ A++T++ + + W L G ++ IYF+ ++ S
Sbjct 374 HWEGPNFGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSTYNWIYFIPLIVLGSF 433
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
+NL L ++ F + + + Q
Sbjct 434 FMLNLVLGVLSGEFAKEREKVENRQSFLKLRRQQQLE 470
Score = 124 bits (310), Expect = 1e-27, Method: Composition-based stats.
Identities = 59/301 (20%), Positives = 107/301 (36%), Gaps = 30/301 (10%)
Query 35 GPGAAARWDLCIDQAVVF-IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLI 93
G A D ID+ I+ IQ R + + + + + V + I +
Sbjct 1173 EQGEAELQDGEIDKNQKSCIDFTIQARPLERYMPKERNSVKYKIWRIVVSTPFEYFIMGL 1232
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
+ L + +D + + + +F + +K FG +F
Sbjct 1233 IVLNTVLLMMKFHRQSDAYKNT---------LKYMNMCFTGMFTVECILKIAAFGVRNFF 1283
Query 154 KNLWLLGYLVVLVVSLVDWTV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIR 210
K+ W + ++ S+VD V + + LR+ R R LL+ ++ L
Sbjct 1284 KDAWNTFDFITVIGSIVDALVIEFGENFINVGFLRLFRAARLIKLLRQGYTIRILLWTFV 1343
Query 211 WSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLT 270
S + V LL+A+ ++ + GM +F D + FQ+ + L L T
Sbjct 1344 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDADTSITKHNNFQSFIQGLMLLFRCAT 1403
Query 271 TANNPDVMIPAYSK----------------NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQ 314
P++M+ N AYA +F+ F S ++NL A+I
Sbjct 1404 GEAWPNIMLSCVKGRPCDAKAGKQEGGCGSNIAYA-YFVSFIFFCSFLMLNLFVAVIMDN 1462
Query 315 F 315
F
Sbjct 1463 F 1463
>sp|P56699|CAC1E_DIPOM Probable voltage-dependent R-type calcium
channel subunit alpha-1E OS=Diplobatis ommata OX=1870830
PE=2 SV=1
Length=2223
Score = 352 bits (904), Expect = 2e-103, Method: Composition-based stats.
Identities = 124/730 (17%), Positives = 253/730 (35%), Gaps = 109/730 (15%)
Query 83 QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSV 142
+R + + F + LA I + + + P E E + +F + +
Sbjct 96 RRVIEWPPFEYMILATI-IANCVVLALEQHLPNGDKTPMAKSLEQTEPYFIGIFCFEAGI 154
Query 143 K----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQN 198
K G++F + +N W + +V++ L+ + LR R+LRP L+
Sbjct 155 KIVALGFVFHKGSYLRNGWNVMDFIVVLSGLLATAATH--FNLRTLRAVRVLRPLKLVSG 212
Query 199 SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD---------- 248
++ LK I ++ + +GLLL + +F + G+ + G
Sbjct 213 IPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYYGKLHRTCYTDDAAAEELDL 272
Query 249 -------------------------RERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS 283
+ +T F N+ +L ++ +T ++
Sbjct 273 QFPCGTQEPTRLCPNGTVCSYWIGPNDGITQFDNILFALLTVFQCITMEGWTTILYNTDD 332
Query 284 --KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVL 341
++FI +IGS F++NL+ ++ +F + R L R ++
Sbjct 333 ALGAMWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENR---RSFLKLRRQQQIE 389
Query 342 SSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ---- 397
+ G +A V + + ++A ++K R S+E+
Sbjct 390 RELNGYRAWIDKAEEVMLLEENKNAGEKSALHVLRRATIKKGRMEMIQTESSEDQYTEIS 449
Query 398 KLFNELDRSVVKEHPPRP------EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICV 451
+ + L R+ +K + S + + + F ++ + N V + V
Sbjct 450 SVGSPLARASIKSTKLLEGSSYFRRKERMLRISIRHMVKSHAFYWIVLGLVALNTVCVAV 509
Query 452 FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
L L F+ + EM LK++ G R Y N FD ++
Sbjct 510 VHYDQPLWLSN-----FLYYAEFTFLGLFSSEMFLKMYGCGPRLYFHSSFNCFDC-GVII 563
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ ++ + + + +++L R LRI K A + +
Sbjct 564 GSIFDVVWTIIRP-----------------ETSFGISVLRALRLLRIFKITKYWASLRNL 606
Query 572 VLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ 628
V+ L+ +M+ + +L + VFA++G+ LF G G
Sbjct 607 VVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEEGTP---------------- 650
Query 629 LEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY-----SGPWSKIYFVLWWLVSSV 683
NFD F AA++T++ ++ +W + + SG WS +YF++ L +
Sbjct 651 ----PTNFDTFPAAIITVFQILTGEDWNEVMYNGIKSQGGVNSGMWSSVYFIVLTLFGNY 706
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE-RL 742
+N+FLA+ ++N + + Q + + + E R
Sbjct 707 TLLNVFLAIAVDNLANAQELTKEEQEEEEAINQKHALQKAKEVSPMSAPGFPSTEREFRR 766
Query 743 SQHPHLWLCR 752
+H +W R
Sbjct 767 HKHMSIWEAR 776
Score = 335 bits (860), Expect = 1e-97, Method: Composition-based stats.
Identities = 109/671 (16%), Positives = 233/671 (35%), Gaps = 98/671 (15%)
Query 54 EDAIQYRSINHRVDASSMWLYRRY--YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADV 111
ED + ++I + +SM+L+R+ VC ++ F + L I S + D
Sbjct 1071 EDEKKSKAI---IPYTSMFLFRKTNPIRRVCHFIVNLRYFEMCILLVIAASSVALAAEDP 1127
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG----YLFGWAHFQKNLWLLGYLVVLVV 167
++ + + + + VF ++ +K +F + +++W + +V+
Sbjct 1128 IHKDSARN---QVLRYFDYVFTGVFTFEMVIKMIDIGLVFHEGSYFRDVWNILDFIVVSG 1184
Query 168 SLVDW--------TVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASV 219
+LV + + + + LR+ R+LRP ++ +K C+ SL + ++
Sbjct 1185 ALVAFAFTNLIGGSSGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNI 1244
Query 220 GLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMI 279
++ + + +F + + LF G D ++T + VL +
Sbjct 1245 LIVYKLFMFIFAVIAVQLFKGKFFY-CTDSSKMTKQDCRGQ-----FVLYRQRTKLSIEN 1298
Query 280 PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFE 339
+ + + LLT S G+ Q +
Sbjct 1299 GNVTTFHYDNVVW------------ALLTLFTVSTGEGWP----QVLQHSVDVTEADQGP 1342
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
+ + + + V P + + + + + +Q S S E+ ++
Sbjct 1343 IPGNRMEMSIFYIVYFVVFPFFFVNIFVALIIITFQEQGDKMLEES------SLEKNERA 1396
Query 400 FNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADV 459
+ S P+ + F F+Y + N V + +
Sbjct 1397 CIDFAISAKPLTRYMPQNRQTFQYRVWQFVVSPSFEYTILTMIALNTVVLMM-----KHH 1451
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
P +L ++N F + + LE +LK+ A G Y NVFD +TVV + EI
Sbjct 1452 SPPPGFASVLKLMNIAFTITFTLECILKIIAFGFLNYFRDSWNVFDF-VTVVGSISEIIV 1510
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
+ L + R ++++ + ++ T + + +
Sbjct 1511 TECNLK---------------FVNLSFLKLFRAARLIKLLRQGITIRILLWTFVQSFKAL 1555
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
++ ++++++AIIG+ LF + NNF F
Sbjct 1556 PYVCLLIAMLFFIYAIIGMQLFGNI------------------GLDDHTPINRHNNFHTF 1597
Query 640 AAALVTLWNLMVVNNWQVFLDAY-----------RRYSGPWSKIYFVLWWLVSSVIWVNL 688
AL+ L+ +WQ + A + YFV + + S + +NL
Sbjct 1598 FNALMLLFRSATGESWQEIMLACLSGKECEGTREPSCGTDVAYFYFVSFIFLCSFLMLNL 1657
Query 689 FLALILENFLH 699
F+A+I++NF +
Sbjct 1658 FVAVIMDNFEY 1668
Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats.
Identities = 71/420 (17%), Positives = 144/420 (34%), Gaps = 48/420 (11%)
Query 330 RRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM----EKVRS 385
+ + +V Q + L + + D + +Q + E +
Sbjct 992 KEESANTSEQVNEQSNWLNLQLNQQATPGDRELTTGTRDTKQDKTQEQTEIDVDCENTET 1051
Query 386 YGSVLLSAEEFQKLFNELDRSVVKEHPPRP-------EYQSPFLQSAQFLFGHYYFDYLG 438
L++ + + K P +P + F+ YF+
Sbjct 1052 PMDSLVTPGNAYSSSSSVKEDEKKSKAIIPYTSMFLFRKTNPIRRVCHFIVNLRYFEMCI 1111
Query 439 NLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG--- 495
L+ A+ V+ L + + + +L + VF + EM++K+ +GL
Sbjct 1112 LLVIAASSVA----LAAEDPIHKDSARNQVLRYFDYVFTGVFTFEMVIKMIDIGLVFHEG 1167
Query 496 -YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFR 554
Y N+ D ++ LV T + + + L +L V R
Sbjct 1168 SYFRDVWNILDFIVVSGALVAFAFTNLIGGSSGKDI-----------NTIKSLRVLRVLR 1216
Query 555 FLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL 614
L+ I + + V V+ ++N+ + + ++FA+I + LF+G +S +
Sbjct 1217 PLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKM 1276
Query 615 APANGSAPCG--------SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL----DAY 662
+ S E ++D+ AL+TL+ + W L D
Sbjct 1277 TKQDCRGQFVLYRQRTKLSIENGNVTTFHYDNVVWALLTLFTVSTGEGWPQVLQHSVDVT 1336
Query 663 RRYSGP------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
GP I+++++++V +VN+F+ALI+ F + D L A
Sbjct 1337 EADQGPIPGNRMEMSIFYIVYFVVFPFFFVNIFVALIIITFQEQGDKMLEESSLEKNERA 1396
Score = 133 bits (334), Expect = 2e-30, Method: Composition-based stats.
Identities = 53/285 (19%), Positives = 104/285 (36%), Gaps = 24/285 (8%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V + +TI ++ L +
Sbjct 1398 IDFAISAKPLTRYMPQNRQTFQYRVWQFVVSPSFEYTILTMIALNTVVLMM-------KH 1450
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
+ P + + + + + F + +K FG+ ++ ++ W + V +V S+ +
Sbjct 1451 HSPPP--GFASVLKLMNIAFTITFTLECILKIIAFGFLNYFRDSWNVFDFVTVVGSISEI 1508
Query 173 TV---SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
V +L V L++ R R LL+ ++ L S + V LL+A+ +
Sbjct 1509 IVTECNLKFVNLSFLKLFRAARLIKLLRQGITIRILLWTFVQSFKALPYVCLLIAMLFFI 1568
Query 230 FTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN---- 285
+ + GM LF DD R F +L L T + ++M+ S
Sbjct 1569 YAIIGMQLFGNIGLDDHTPINRHNNFHTFFNALMLLFRSATGESWQEIMLACLSGKECEG 1628
Query 286 --------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+F+ F + S ++NL A+I F S
Sbjct 1629 TREPSCGTDVAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDS 1673
>sp|Q61290|CAC1E_MOUSE Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Mus musculus OX=10090 GN=Cacna1e PE=1
SV=1
Length=2272
Score = 351 bits (901), Expect = 5e-103, Method: Composition-based stats.
Identities = 137/767 (18%), Positives = 266/767 (35%), Gaps = 112/767 (15%)
Query 8 SEPLLGGARGGGGDWPAGLTTYRSIQV--GPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
++G G GD + GP AA + + + + I R
Sbjct 6 EAVVVGRPGSGDGDSDQSRNRQGTPVPASGPAAAYKQSKAQRARTMALYNPIPVRQNCFT 65
Query 66 VDASSM-WLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL 124
V+ S + ++ + + F + LA I + + + P
Sbjct 66 VNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATI-IANCIVLALEQHLPEDDKTPMSRR 124
Query 125 TESVEVLCLLVFAADLSVKGYLFGW----AHFQKNLWLLGYLVVLV-VSLVDWTVSLSL- 178
E E + +F + +K G+ + +N W + +V++ L +
Sbjct 125 LEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTH 184
Query 179 VCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF 238
V LR R+LRP L+ ++ LK I ++ + +GLLL + +F + G+ +
Sbjct 185 VDLRALRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 244
Query 239 AGGKQDDGQDRE--------------------------------RLTYFQNLPESLTSLL 266
+G +T F N+ ++ ++
Sbjct 245 SGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVF 304
Query 267 VLLTTANNPDVMIPAYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMK 321
+T V+ Y+ N ++FI +IGS F++NL+ ++ +F +
Sbjct 305 QCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERER 361
Query 322 SLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNL--------LQVLQKVQLDS 373
F + R ++ + G +A V L+VL++ +
Sbjct 362 VENRRAFMK---LRRQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKR 418
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
S +AM V +S+ + + V + S + +
Sbjct 419 SRTEAMTRDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQV 478
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F ++ + N + + + +L +F+ +LLEM LK++ +G
Sbjct 479 FYWIVLSVVALNTACVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGP 533
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
R Y N FD +T V + E+ + +++L
Sbjct 534 RLYFHSSFNCFDFGVT-VGSIFEVVWAIFRPG-----------------TSFGISVLRAL 575
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPG 610
R LRI K A + + V+ L+ +M+ + +L + VFA++G+ LF G G
Sbjct 576 RLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDG 635
Query 611 NSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR-----Y 665
S NFD F AA++T++ ++ +W + R
Sbjct 636 TPSA--------------------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVS 675
Query 666 SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
SG WS IYF++ L + +N+FLA+ ++N + + Q
Sbjct 676 SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 722
Score = 327 bits (838), Expect = 1e-94, Method: Composition-based stats.
Identities = 107/653 (16%), Positives = 221/653 (34%), Gaps = 97/653 (15%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C ++ F + L I S + D + + + + VF
Sbjct 1145 IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERN---KVLRYFDYVFTGVFT 1201
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--------HEPLR 185
++ +K G + ++LW + VV+V +LV + ++ +L + LR
Sbjct 1202 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1261
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1262 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY- 1320
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
D + T + + + + + N +A L+
Sbjct 1321 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWA-------------LLT 1367
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L T + L S+ + R E+ V FP L+ +
Sbjct 1368 LFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIII 1427
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ Q D ++ +EK E + + + + P+ + F
Sbjct 1428 TFQEQGDKMMEECSLEK-----------NERACIDFAISAKPLTRYMPQNRHT--FQYRV 1474
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + L LN F + + LE +
Sbjct 1475 WHFVVSPSFEYTIMAMIALNTVVLMM-----KYYTAPCTYELALKYLNIAFTMVFSLECV 1529
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LKV A G Y N+FD +TV+ + EI + G+
Sbjct 1530 LKVIAFGFLNYFRDTWNIFDF-ITVIGSITEIILTDSKLVNTSGFNMSF----------- 1577
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1578 -LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1636
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ E NNF F +L+ L+ WQ + +
Sbjct 1637 L------------------DEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE 1678
Query 666 SG-------------------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
G + +YFV + S + +NLF+A+I++NF +
Sbjct 1679 KGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1731
Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats.
Identities = 49/268 (18%), Positives = 96/268 (36%), Gaps = 32/268 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+P ++ ++ YF+ L+ A+ + L + VL + +L + VF
Sbjct 1142 TNPIRRACHYIVNLRYFEMCILLVIAASS----IALAAEDPVLTNSERNKVLRYFDYVFT 1197
Query 478 VYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ EM++K+ GL Y N+ D V++V + A+
Sbjct 1198 GVFTFEMVIKMIDQGLILQDGSYFRDLWNILDF----VVVVGALVAFALANALGTNKG-- 1251
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
+ L +L V R L+ I + + V V+ ++N+ + + ++F
Sbjct 1252 -----RDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIF 1306
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALV 644
A+I + LF+G +S E + + ++D+ AL+
Sbjct 1307 AVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALL 1366
Query 645 TLWNLMVVNNWQVFL----DAYRRYSGP 668
TL+ + W L D GP
Sbjct 1367 TLFTVSTGEGWPQVLQHSVDVTEEDRGP 1394
Score = 165 bits (418), Expect = 9e-41, Method: Composition-based stats.
Identities = 59/348 (17%), Positives = 125/348 (36%), Gaps = 43/348 (12%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ L F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 77 NIVRKYAKKLIDWPPFEY----MILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYF 132
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D ++ + G
Sbjct 133 IGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL-----------------SGILA 175
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R L + V R L+++ + + +V +++ + + G +L +
Sbjct 176 TAGTHFNTHVDLRALRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 235
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAP--------------CGSFEQLEYWANNFDD 638
FAIIG+ + G + ++ G P C + FD+
Sbjct 236 FAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 295
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILENF 697
A++T++ + + W L G W+ +YF+ ++ S +NL L ++ F
Sbjct 296 ILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 355
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQH 745
+ + + + Q+ EL + E+ + +++
Sbjct 356 AKERERVENRRAFM-KLRRQQQIERELNGYRAWIDKAEEVMLAEENKN 402
Score = 137 bits (345), Expect = 8e-32, Method: Composition-based stats.
Identities = 63/347 (18%), Positives = 126/347 (36%), Gaps = 26/347 (7%)
Query 8 SEPLLGGARGGGGDWP------AGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
E +L G A + R+ + ++ + I + A +
Sbjct 392 EEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKST 451
Query 62 INHRVDASSMWLYRRYYSNVC-QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
+VD +S + ++ + + + +F + L+ + ++ + V + W
Sbjct 452 ---KVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTACVAI--VHHNQPQWLT 506
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLV 179
L E L L +F ++S+K Y G + + + V V S+ +
Sbjct 507 H--LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPG 564
Query 180 C---HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
LR RLLR F + + + ++ + + S+ + S+ LL + + +F + GM
Sbjct 565 TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 624
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------AYSKNRAYAI 290
LF G + D F P ++ ++ +LT + +VM S AI
Sbjct 625 LFGGRF--NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAI 682
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
+FIV T+ G+ L+N+ AI + + A
Sbjct 683 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHA 729
Score = 127 bits (319), Expect = 1e-28, Method: Composition-based stats.
Identities = 52/296 (18%), Positives = 112/296 (38%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V + +TI ++ L + ++
Sbjct 1450 IDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLM--------MK 1501
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y AP L + + + +VF+ + +K FG+ ++ ++ W + + ++ S+ +
Sbjct 1502 YYTAPCTYELAL-KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEI 1560
Query 173 TVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
++ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1561 ILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1620
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN- 285
++ + GM +F K D+ R F++ SL L T ++M+ +
Sbjct 1621 FFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1680
Query 286 -------------------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
++F+ F S ++NL A+I F S
Sbjct 1681 CEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDS 1736
>sp|Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Homo sapiens OX=9606 GN=CACNA1E PE=1 SV=3
Length=2313
Score = 351 bits (900), Expect = 7e-103, Method: Composition-based stats.
Identities = 125/693 (18%), Positives = 245/693 (35%), Gaps = 109/693 (16%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ + + F + LA I + + + P E E + +F
Sbjct 79 RKYAKKLIDWPPFEYMILATI-IANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCF 137
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLV-VSLVDWTVSLSL-VCHEPLRIRRLLRP 192
+ +K G+ + +N W + +V++ L + V LR R+LRP
Sbjct 138 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 197
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE-- 250
L+ ++ LK I ++ + +GLLL + +F + G+ ++G
Sbjct 198 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSG 257
Query 251 ------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVMIP 280
+T F N+ ++ ++ +T V+
Sbjct 258 ILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVL-- 315
Query 281 AYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
Y+ N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 316 -YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK---LR 371
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNL--------LQVLQKVQLDSSHKQAMMEKVRSYG 387
++ + G +A V L+VL++ + S +AM
Sbjct 372 RQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEH 431
Query 388 SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLV 447
V +S+ + + V + S + + F ++ + N
Sbjct 432 CVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTA 491
Query 448 SICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
+ + + +L +F+ +LLEM LK++ +G R Y N FD
Sbjct 492 CVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFG 546
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+T V + E+ + +++L R LRI K A
Sbjct 547 VT-VGSIFEVVWAIFRPG-----------------TSFGISVLRALRLLRIFKITKYWAS 588
Query 568 VASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
+ + V+ L+ +M+ + +L + VFA++G+ LF G G S
Sbjct 589 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA---------- 638
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR-----YSGPWSKIYFVLWWL 679
NFD F AA++T++ ++ +W + R SG WS IYF++ L
Sbjct 639 ----------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTL 688
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ +N+FLA+ ++N + + Q
Sbjct 689 FGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 721
Score = 328 bits (840), Expect = 6e-95, Method: Composition-based stats.
Identities = 107/653 (16%), Positives = 221/653 (34%), Gaps = 97/653 (15%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C ++ F + L I S + D + + + + VF
Sbjct 1142 IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERN---KVLRYFDYVFTGVFT 1198
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--------HEPLR 185
++ +K G + ++LW + VV+V +LV + ++ +L + LR
Sbjct 1199 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1259 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY- 1317
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
D + T + + + + + N +A L+
Sbjct 1318 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWA-------------LLT 1364
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L T + L S+ + R E+ V FP L+ +
Sbjct 1365 LFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIII 1424
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ Q D ++ +EK E + + + + P+ + F
Sbjct 1425 TFQEQGDKMMEECSLEK-----------NERACIDFAISAKPLTRYMPQNRHT--FQYRV 1471
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + L LN F + + LE +
Sbjct 1472 WHFVVSPSFEYTIMAMIALNTVVLMM-----KYYSAPCTYELALKYLNIAFTMVFSLECV 1526
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LKV A G Y N+FD +TV+ + EI + G+
Sbjct 1527 LKVIAFGFLNYFRDTWNIFDF-ITVIGSITEIILTDSKLVNTSGFNMSF----------- 1574
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1575 -LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1633
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ E NNF F +L+ L+ WQ + +
Sbjct 1634 L------------------DEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE 1675
Query 666 SG-------------------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
G + +YFV + S + +NLF+A+I++NF +
Sbjct 1676 KGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1728
Score = 176 bits (445), Expect = 4e-44, Method: Composition-based stats.
Identities = 49/268 (18%), Positives = 96/268 (36%), Gaps = 32/268 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+P ++ ++ YF+ L+ A+ + L + VL + +L + VF
Sbjct 1139 TNPIRRACHYIVNLRYFEMCILLVIAASS----IALAAEDPVLTNSERNKVLRYFDYVFT 1194
Query 478 VYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ EM++K+ GL Y N+ D V++V + A+
Sbjct 1195 GVFTFEMVIKMIDQGLILQDGSYFRDLWNILDF----VVVVGALVAFALANALGTNKG-- 1248
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
+ L +L V R L+ I + + V V+ ++N+ + + ++F
Sbjct 1249 -----RDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIF 1303
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALV 644
A+I + LF+G +S E + + ++D+ AL+
Sbjct 1304 AVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALL 1363
Query 645 TLWNLMVVNNWQVFL----DAYRRYSGP 668
TL+ + W L D GP
Sbjct 1364 TLFTVSTGEGWPQVLQHSVDVTEEDRGP 1391
Score = 166 bits (419), Expect = 7e-41, Method: Composition-based stats.
Identities = 59/348 (17%), Positives = 125/348 (36%), Gaps = 43/348 (12%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ L F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 76 NIVRKYAKKLIDWPPFEY----MILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYF 131
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D ++ + G
Sbjct 132 IGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL-----------------SGILA 174
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R L + V R L+++ + + +V +++ + + G +L +
Sbjct 175 TAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 234
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAP--------------CGSFEQLEYWANNFDD 638
FAIIG+ + G + ++ G P C + FD+
Sbjct 235 FAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 294
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILENF 697
A++T++ + + W L G W+ +YF+ ++ S +NL L ++ F
Sbjct 295 ILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 354
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQH 745
+ + + + Q+ EL + E+ + +++
Sbjct 355 AKERERVENRRAFM-KLRRQQQIERELNGYRAWIDKAEEVMLAEENKN 401
Score = 136 bits (342), Expect = 2e-31, Method: Composition-based stats.
Identities = 63/347 (18%), Positives = 125/347 (36%), Gaps = 26/347 (7%)
Query 8 SEPLLGGARGGGGDWP------AGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
E +L G A + R+ + ++ + I + A
Sbjct 391 EEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARA---SI 447
Query 62 INHRVDASSMWLYRRYYSNVC-QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
+ +VD S + ++ + + + +F + L+ + ++ + V + W
Sbjct 448 KSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAI--VHHNQPQWLT 505
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLV 179
L E L L +F ++S+K Y G + + + V V S+ +
Sbjct 506 H--LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPG 563
Query 180 C---HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
LR RLLR F + + + ++ + + S+ + S+ LL + + +F + GM
Sbjct 564 TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 623
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------AYSKNRAYAI 290
LF G + D F P ++ ++ +LT + +VM S AI
Sbjct 624 LFGGRF--NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAI 681
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
+FIV T+ G+ L+N+ AI + + A
Sbjct 682 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHA 728
Score = 129 bits (323), Expect = 4e-29, Method: Composition-based stats.
Identities = 53/296 (18%), Positives = 115/296 (39%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V + +TI ++ L + ++
Sbjct 1447 IDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLM--------MK 1498
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y +AP L + + + +VF+ + +K FG+ ++ ++ W + + ++ S+ +
Sbjct 1499 YYSAPCTYELAL-KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEI 1557
Query 173 TVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
++ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1558 ILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1617
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA----- 281
++ + GM +F K D+ R F++ SL L T ++M+
Sbjct 1618 FFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1677
Query 282 ----------YSKNRA-----YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
++N ++F+ F S ++NL A+I F S
Sbjct 1678 CEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDS 1733
>sp|Q9ULQ1|TPC1_HUMAN Two pore channel protein 1 OS=Homo sapiens
OX=9606 GN=TPCN1 PE=1 SV=3
Length=816
Score = 336 bits (861), Expect = 2e-102, Method: Composition-based stats.
Identities = 156/620 (25%), Positives = 265/620 (43%), Gaps = 58/620 (9%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRI 186
++E+ L+V +L +K G F ++ + VLVV V+ V L R+
Sbjct 142 TLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHV-RV 200
Query 187 RRLLRPFFLL--QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQD 244
R LR FL+ + +++ L+ I SLP + LLL + +F + G LF+ D
Sbjct 201 TRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSD 260
Query 245 DGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLM 304
YF L S+ SL VLLTTAN PDVM+P+YS+N +FFIV+ I F+M
Sbjct 261 P--------YFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIM 312
Query 305 NLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
NLL A+++ F + ++ L +R + A+ +L S G + + L
Sbjct 313 NLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAG-----ISYRQFEGLM 367
Query 365 VLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPF--- 421
K ++ + + + + + LLS ++F ++ E+ K R +
Sbjct 368 RFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIY-EVAALKWKAKKNREHWFDELPRT 426
Query 422 ----LQSAQFLFGHYYFDYLGNLIALANLVSICV--FLVLDADVLPAERDDFILGILNCV 475
+ L F Y L+ N V I V F++ + L V
Sbjct 427 ALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL-----V 481
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F+ Y +E+ LKV LG YLS N+FD +T + P
Sbjct 482 FLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVT-------VFAFLGLLALALNMEPFYF 534
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+ +L + LR+ + V T+ L+ M + G L++ YY FAI
Sbjct 535 IV-----------VLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAI 583
Query 596 IGINLFRGVIVALPGNSSLAPA------NGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+G+ F G++ N+S + E+ Y+ NNFD+ + VTL+ L
Sbjct 584 VGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFEL 643
Query 650 MVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ- 708
VVNNW + ++ + WS++YF+ +++V+ ++ + + +A ILE F+ + + Q
Sbjct 644 TVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVT-MVVMTIIVAFILEAFVFRMNYSRKNQD 702
Query 709 -PLAGTPEATYQMTVELLFR 727
+ G +++ E L
Sbjct 703 SEVDGGITLEKEISKEELVA 722
>sp|Q07652|CAC1E_RAT Voltage-dependent R-type calcium channel
subunit alpha-1E OS=Rattus norvegicus OX=10116 GN=Cacna1e PE=1
SV=1
Length=2222
Score = 349 bits (894), Expect = 5e-102, Method: Composition-based stats.
Identities = 125/693 (18%), Positives = 244/693 (35%), Gaps = 109/693 (16%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ + + F + LA I + + P E E + +F
Sbjct 30 RKYAKKLIDWPPFEYMILATIIANCIVLALE-QHLPEDDKTPMSRRLEKTEPYFIGIFCF 88
Query 139 DLSVKGYLFGW----AHFQKNLWLLGYLVVLV-VSLVDWTVSLSL-VCHEPLRIRRLLRP 192
+ +K G+ + +N W + +V++ L + V LR R+LRP
Sbjct 89 EAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 148
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE-- 250
L+ ++ LK I ++ + +GLLL + +F + G+ ++G
Sbjct 149 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSG 208
Query 251 ------------------------------RLTYFQNLPESLTSLLVLLTTANNPDVMIP 280
+T F N+ ++ ++ +T V+
Sbjct 209 ILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVL-- 266
Query 281 AYSKNR-----AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
Y+ N ++FI +IGS F++NL+ ++ +F + F + R
Sbjct 267 -YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK---LR 322
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNL--------LQVLQKVQLDSSHKQAMMEKVRSYG 387
++ + G +A V L+VL++ + S +AM
Sbjct 323 RQQQIERELNGYRAWIDKAEEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEH 382
Query 388 SVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLV 447
V +S+ + + V + S + + F ++ + N
Sbjct 383 CVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTA 442
Query 448 SICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
+ + + +L +F+ +LLEM LK++ +G R Y N FD
Sbjct 443 CVAI-----VHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFG 497
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+T V + E+ + +++L R LRI K A
Sbjct 498 VT-VGSIFEVVWAIFRPG-----------------TSFGISVLRALRLLRIFKITKYWAS 539
Query 568 VASTVLGLVQNMR---AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
+ + V+ L+ +M+ + +L + VFA++G+ LF G G S
Sbjct 540 LRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSA---------- 589
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR-----YSGPWSKIYFVLWWL 679
NFD F AA++T++ ++ +W + R SG WS IYF++ L
Sbjct 590 ----------NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTL 639
Query 680 VSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
+ +N+FLA+ ++N + + Q
Sbjct 640 FGNYTLLNVFLAIAVDNLANAQELTKDEQEEEE 672
Score = 325 bits (833), Expect = 4e-94, Method: Composition-based stats.
Identities = 107/653 (16%), Positives = 221/653 (34%), Gaps = 97/653 (15%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
C ++ F + L I S + D + + + + VF
Sbjct 1094 IRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERN---KVLRYFDYVFTGVFT 1150
Query 138 ADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--------HEPLR 185
++ +K G + ++LW + VV+V +LV + ++ +L + LR
Sbjct 1151 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1210
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ R+LRP ++ +K C+ SL + ++ ++ + + +F + + LF G
Sbjct 1211 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFY- 1269
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
D + T + + + + + N +A L+
Sbjct 1270 CTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWA-------------LLT 1316
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L T + L S+ + R E+ V FP L+ +
Sbjct 1317 LFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIII 1376
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ Q D ++ +EK E + + + + P+ + F
Sbjct 1377 TFQEQGDKMMEECSLEK-----------NERACIDFAISAKPLTRYMPQNRHT--FQYRV 1423
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
F+Y + N V + + + L LN F + + LE +
Sbjct 1424 WHFVVSPSFEYTIMAMIALNTVVLMM-----KYYSAPWTYELALKYLNIAFTMVFSLECV 1478
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LKV A G Y N+FD +TV+ + EI + G+
Sbjct 1479 LKVIAFGFLNYFRDTWNIFDF-ITVIGSITEIILTDSKLVNTSGFNMSF----------- 1526
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 1527 -LKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIK 1585
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ E NNF F +L+ L+ WQ + +
Sbjct 1586 L------------------DEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE 1627
Query 666 SG-------------------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
G + +YFV + S + +NLF+A+I++NF +
Sbjct 1628 KGCEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEY 1680
Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats.
Identities = 49/268 (18%), Positives = 96/268 (36%), Gaps = 32/268 (12%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFI 477
+P ++ ++ YF+ L+ A+ + L + VL + +L + VF
Sbjct 1091 TNPIRKACHYIVNLRYFEMCILLVIAASS----IALAAEDPVLTNSERNKVLRYFDYVFT 1146
Query 478 VYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+ EM++K+ GL Y N+ D V++V + A+
Sbjct 1147 GVFTFEMVIKMIDQGLILQDGSYFRDLWNILDF----VVVVGALVAFALANALGTNKG-- 1200
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
+ L +L V R L+ I + + V V+ ++N+ + + ++F
Sbjct 1201 -----RDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIF 1255
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE---------QLEYWANNFDDFAAALV 644
A+I + LF+G +S E + + ++D+ AL+
Sbjct 1256 AVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALL 1315
Query 645 TLWNLMVVNNWQVFL----DAYRRYSGP 668
TL+ + W L D GP
Sbjct 1316 TLFTVSTGEGWPQVLQHSVDVTEEDRGP 1343
Score = 164 bits (415), Expect = 2e-40, Method: Composition-based stats.
Identities = 59/348 (17%), Positives = 125/348 (36%), Gaps = 43/348 (12%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD--DFILGILNCVF 476
+ + A+ L F+Y + LA +++ C+ L L+ + ++ L F
Sbjct 27 NIVRKYAKKLIDWPPFEY----MILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYF 82
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
I + E +K+ ALG YL NV D ++ + G
Sbjct 83 IGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVL-----------------SGILA 125
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R L + V R L+++ + + +V +++ + + G +L +
Sbjct 126 TAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILM 185
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAP--------------CGSFEQLEYWANNFDD 638
FAIIG+ + G + ++ G P C + FD+
Sbjct 186 FAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDN 245
Query 639 FAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSVIWVNLFLALILENF 697
A++T++ + + W L G W+ +YF+ ++ S +NL L ++ F
Sbjct 246 ILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 305
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQH 745
+ + + + Q+ EL + E+ + +++
Sbjct 306 AKERERVENRRAFM-KLRRQQQIERELNGYRAWIDKAEEVMLAEENKN 352
Score = 136 bits (343), Expect = 1e-31, Method: Composition-based stats.
Identities = 63/347 (18%), Positives = 126/347 (36%), Gaps = 26/347 (7%)
Query 8 SEPLLGGARGGGGDWP------AGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRS 61
E +L G A + R+ + ++ + I + A +
Sbjct 342 EEVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKST 401
Query 62 INHRVDASSMWLYRRYYSNVC-QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
+VD +S + ++ + + + +F + L+ + ++ + V + W
Sbjct 402 ---KVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTACVAI--VHHNQPQWLT 456
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT-VSLSLV 179
L E L L +F ++S+K Y G + + + V V S+ +
Sbjct 457 H--LLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPG 514
Query 180 C---HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
LR RLLR F + + + ++ + + S+ + S+ LL + + +F + GM
Sbjct 515 TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 574
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------AYSKNRAYAI 290
LF G + D F P ++ ++ +LT + +VM S AI
Sbjct 575 LFGGRF--NFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAI 632
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
+FIV T+ G+ L+N+ AI + + A
Sbjct 633 YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHA 679
Score = 131 bits (330), Expect = 6e-30, Method: Composition-based stats.
Identities = 53/296 (18%), Positives = 114/296 (39%), Gaps = 35/296 (12%)
Query 53 IEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
I+ AI + + + + R + V + +TI ++ L + ++
Sbjct 1399 IDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLM--------MK 1450
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
Y +APW L + + + +VF+ + +K FG+ ++ ++ W + + ++ S+ +
Sbjct 1451 YYSAPWTYELAL-KYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEI 1509
Query 173 TVSLSLVCHEP------LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
++ S + + L++ R R LL+ ++ L S + V LL+A+
Sbjct 1510 ILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1569
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN- 285
++ + GM +F K D+ R F++ SL L T ++M+ +
Sbjct 1570 FFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1629
Query 286 -------------------RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
++F+ F S ++NL A+I F S
Sbjct 1630 CEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDS 1685
>sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Triticum
aestivum OX=4565 GN=TPC1 PE=2 SV=1
Length=742
Score = 328 bits (841), Expect = 4e-100, Method: Composition-based stats.
Identities = 175/752 (23%), Positives = 308/752 (41%), Gaps = 73/752 (10%)
Query 14 GARGGGGDWPAGLTTYRSIQVGPG-----AAARWDLCIDQAVVFIEDAIQYRSINHRVDA 68
G G + RS + G AAA DL D + + R
Sbjct 25 RLSDGAGGQGSRKYRRRSDALAYGDRYQKAAALVDLAEDGVGIPEDVLNDTR-------- 76
Query 69 SSMWLYRRYYSNVCQ--RTLSFTIFLILFLAFIETP-----SSLTSTADVRYRAAPWEPP 121
+Y + S +F ++ L F+E P +L + P
Sbjct 77 --FGRAMSFYFVYLRLDWLWSLNLFALILLNFLEKPLWCRKDALQAYDQRDLYFLGQLPY 134
Query 122 CGLTESV--EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV 179
TES+ E L L++ D+ G F ++ L ++++ ++ + +
Sbjct 135 FSKTESLIYEGLTLVILVMDIFCPLSYEGLNIFWRS--TTNKLKIVLLFILACDILVFAF 192
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+P R+ +R FL+ ++ + + +V L + L + + F
Sbjct 193 SSQPFRLAPYIRVVFLIMTIRELRMCAITLAGLIGTYLNVLALSLLFLLFASWLAYVTFE 252
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ T F + +L + VL TT+NNPDV + AY R Y++FFIV+ ++G
Sbjct 253 -------DTPQGKTIFSSYGVTLYQMFVLFTTSNNPDVWVHAYKIPRWYSLFFIVYVLLG 305
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
FL NL+ A+IY F+ K L R+ + AF+++ + G +
Sbjct 306 VYFLTNLILAVIYDSFKEQFAKQLVQVDSIRKNILQKAFDLIDT-NNRGYLDREQCISLL 364
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR----- 414
L + + + + ++ G +++EEF L N + KE PP
Sbjct 365 NELNKYRSLPKTSREDFELIFAELDRSGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKF 424
Query 415 PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC 474
P Y SP + F+Y+ + L NLV++ + LD + ++ +
Sbjct 425 PFYHSPLCGRLKSFVRSRMFEYIIVFVLLINLVAVIIETTLDIENSSSQET---WQEVEF 481
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y+ EM LK+F+LG Y N FD +LT + + E T A P
Sbjct 482 FLGWIYVAEMALKIFSLGFGAYWMEGQNKFDFVLTWTIFIGETLTFAF---------PSK 532
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ LS + R L + V R RI+ ++ +T L+ ++ + GI+ V ++
Sbjct 533 LPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRAFVATFFTLMSSLMPYLGIVFCVLCMYC 592
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN 654
IG+ +F G++ A GN +L + +Y NF+D+ + +VTL+NL+V+ N
Sbjct 593 SIGLQIFGGIVYA--GNPTLEETDLFNN-------DYLLFNFNDYPSGMVTLFNLLVMGN 643
Query 655 WQVFLDAYRRYSG-PWSKIYFVLWWLVSSVIWVNLFLALILENF-----LHKWDPRSHLQ 708
WQV++++Y + +G WS IYFV ++L+S ++ +NL +A +LE F L K +
Sbjct 644 WQVWMESYWQLTGTSWSLIYFVSFYLISILLLLNLIVAFVLEAFFAEMELEKGEEVDIQN 703
Query 709 PLAGTPEATYQMTVE-------LLFRDILEEP 733
P +G + M V +L +L
Sbjct 704 PTSGGIKKRRSMRVRSKGTMVDILLHHMLSNE 735
>sp|B1AYL1|SCN7A_MOUSE Sodium channel protein type 7 subunit alpha
OS=Mus musculus OX=10090 GN=Scn7a PE=1 SV=1
Length=1681
Score = 342 bits (876), Expect = 6e-100, Method: Composition-based stats.
Identities = 110/667 (16%), Positives = 244/667 (37%), Gaps = 92/667 (14%)
Query 54 EDAIQYRSINHRVDA-SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR 112
++ + +S ++ S + C + + + F + + D+
Sbjct 898 KNGYERKSSTGQISRESRNGKIWKNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIY 957
Query 113 YRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDW 172
+ L E +++ +F ++ +K +G+ F N W +V++V +
Sbjct 958 IDQ--RKTTKILLEYADMIFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLSL 1015
Query 173 T--VSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
L ++ R LR MK L+ + + SV L+ + LF
Sbjct 1016 IGKTREDLNPLTSIKFLRALRVL---SQFERMKVVLRALIKTTLPTVSVFLVCLMIWLLF 1072
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
++ G+ LFAG +++ + + + N ++++ +
Sbjct 1073 SVIGVQLFAGK------------FYECIDPTKGERFPVFEVMNKSQCEKLLFNESMPWEN 1120
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGA 350
+ F +G+ FL L A F G++ + +++ + + +FE M
Sbjct 1121 AKLNFDNVGNGFLSLLQVA----TFNGWI-SIMNSAIDSVGVNMQPSFEYNLYMYSYFII 1175
Query 351 FPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKE 410
F P +L V + + +KQ K++ GS + + +K + L + + +
Sbjct 1176 FVIFGLFLPLCML---IGVIIRNFNKQ----KIKQGGSNIFITVKQKKQYRALKKLLYAD 1228
Query 411 -HPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
P P ++ F L H F+ + L+ +I + D + + I
Sbjct 1229 VQKPTPRPRNKFQGFLFDLVTHRVFNVIIILLICFQATTIMI----QKDEQSPQMETAIF 1284
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
+N +F++ + LE +LK+ A Y + NV D ++++ I+ L +
Sbjct 1285 -WMNSIFVMLFTLECILKLTAFR-CHYFTSAWNVHDF----MVVIFSITGLLLPLTIGQY 1338
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+ P + +++ + V LR K+ + ++ + + ++ +V
Sbjct 1339 FVPP--------SLVQLILLSRVIHILRPGKGPKVFHDLMLPLILALPALLNISLLIFLV 1390
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+++AI G+ F V N +NF+ F ++++ L+ +
Sbjct 1391 MFIYAIFGMYNFAYVKKEAGIND--------------------VSNFETFGSSMLCLFQV 1430
Query 650 MVVNNWQVFLDAY---------RRYSGPWSKI------------YFVLWWLVSSVIWVNL 688
+ W LDA P +++ YFV + L+S +I VN+
Sbjct 1431 TTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNM 1490
Query 689 FLALILE 695
++ LI+E
Sbjct 1491 YIVLIME 1497
Score = 171 bits (433), Expect = 1e-42, Method: Composition-based stats.
Identities = 48/357 (13%), Positives = 119/357 (33%), Gaps = 43/357 (12%)
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA 457
+ + + ++ + + +F+ L+ L ++ + D
Sbjct 900 GYERKSSTGQISRESRNGKIWKNIRKTCCKIVENSWFECFIGLVTLLCTGTLALE---DI 956
Query 458 DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEI 517
+ + +L + +F ++LEMLLK A G + + S D ++ +V + I
Sbjct 957 YIDQRKTTKILLEYADMIFAYIFILEMLLKWVAYGFKAFFSNNWYKLDFMVVIVFCLSLI 1016
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ L + R LR++ + M VV ++
Sbjct 1017 G--------------------KTREDLNPLTSIKFLRALRVLSQFERMKVVLRALIKTTL 1056
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA-------PANGSAPCGSFEQLE 630
+ + ++++ +F++IG+ LF G + F +
Sbjct 1057 PTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCEKLLFNESM 1116
Query 631 YWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP----------WSKIYFVLW 677
W N NFD+ ++L + N W +++ G + YF+++
Sbjct 1117 PWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLYMYSYFIIF 1176
Query 678 WLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPG 734
+ + + + + +I+ NF + + + ++ L +++P
Sbjct 1177 VIFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPT 1233
Score = 153 bits (387), Expect = 6e-37, Method: Composition-based stats.
Identities = 108/676 (16%), Positives = 205/676 (30%), Gaps = 117/676 (17%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ L +F +L L + T S L + W ++E L ++A
Sbjct 109 RRAAIKALVHPLFRLLILISVLTDSILMCMS----NLPEW------ILAIENTLLGIYAF 158
Query 139 DLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ VK G G F +LW V + L+ T L L+ R R
Sbjct 159 EILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELI--TRFSPLSSFLMLKTIRTFRILK 216
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG-------- 246
++ + ++ + + L ++ L L +F++ GM LF G +
Sbjct 217 IIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLFMGNLKHKCLRWPEENE 276
Query 247 ------------QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
ER+ ++ L T A + F
Sbjct 277 NETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGYVCVKEGTNPDNGFTS 336
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF--- 351
F G L+ + + + L S + + M+ AF
Sbjct 337 FDNFG-WSLLAMFRLMTQDYPELLYHQILYASG--------KVYMIFFVMISFWFAFYLT 387
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKE- 410
+G+ + Q+ +S ++ A E + E+ +
Sbjct 388 SLFLGILTMTYEKEKQRACEESGGLDPKCQQTVKELDEENDAAEMETTQIEMKKRSPTSI 447
Query 411 -------------HPPRPEYQSPFLQSAQFLFGHYYFDY--------------------L 437
H PE F F + L
Sbjct 448 NTTLDILEDTTLGHREEPETSRKKCPICWHKFIKTCFIWKCSPCWVKLNEFADRVITHPL 507
Query 438 GNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL 497
+L + +V FL L+ +E +L + N VFI Y +EM+LK+ A+ GY
Sbjct 508 ADLFLVICIVLNICFLALE-HFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYF 566
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+FD +L VL + EI V L P F++
Sbjct 567 QISWNIFDSILV-VLELTEILLADVEGLAVLITVP--------------------LIFIK 605
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+ + + + ++ +L + Y A+ G+ LF +
Sbjct 606 LGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLFG-----------RSYK 654
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLW 677
+ Q + W DF A +T++ ++ + + W ++++
Sbjct 655 DCVCHIKEDCQPQRWHM--SDFLHAYMTVFRILCGEWIETLWECMEVAGQAWCIPFYMMV 712
Query 678 WLVSSVIWVNLFLALI 693
L+ +++ + LF+ L+
Sbjct 713 ILIGNLLILYLFVTLV 728
Score = 95.6 bits (236), Expect = 8e-19, Method: Composition-based stats.
Identities = 61/374 (16%), Positives = 122/374 (33%), Gaps = 81/374 (22%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++A H F L + L + + +C + ++IL I N +
Sbjct 106 NSLRRAAIKALVHPLFRLLILISVLTDSILMC----------MSNLPEWILAIEN-TLLG 154
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E+L+KV A G+ +L N D +T+ L+ S L+ + +
Sbjct 155 IYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFSPLSSFLM--------- 205
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + FR L+IIP + + T+ ++ + + + VF+
Sbjct 206 ------------LKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFS 253
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
++G+ LF G +
Sbjct 254 LLGMGLFMGNLKHKCLRWPEENENETLHNRTGSLNYSPERINFYYMEGAKYALLCGNRTD 313
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ G + +FD+F +L+ ++ LM + ++ SG I
Sbjct 314 AGQCPEGYVCVKEGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMI 373
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEE 732
+FV+ + +LFL ++ + + + +G + Q TV+ L +
Sbjct 374 FFVMISFWFAFYLTSLFLGILTMTYEKE---KQRACEESGGLDPKCQQTVKELDEENDAA 430
Query 733 PGEDELTERLSQHP 746
E E + P
Sbjct 431 EMETTQIEMKKRSP 444
Score = 72.5 bits (176), Expect = 1e-11, Method: Composition-based stats.
Identities = 32/247 (13%), Positives = 83/247 (34%), Gaps = 13/247 (5%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
+ R ++ + + + I + E L ++ +
Sbjct 492 WVKLNEFADRVITHPLADLFLVICIVLNICFLALE----HFPMSEELRSLLHVGNLVFIG 547
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ ++ +K + + W + +++V+ L + + L L+
Sbjct 548 IYTIEMILKIIAMHPYGYFQISWNIFDSILVVLEL-TEILLADVEGLAVLITVPLI-FIK 605
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD-----GQDR 249
L + K ++ + SL + + LLL I + +FGM LF +D +
Sbjct 606 LGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLFGRSYKDCVCHIKEDCQ 665
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLT 308
+ + + + ++ +L + + +A+ I F + ++ L+ L
Sbjct 666 PQRWHMSDFLHAYMTVFRILCGE-WIETLWECMEVAGQAWCIPFYMMVILIGNLLILYLF 724
Query 309 AIIYSQF 315
+ S F
Sbjct 725 VTLVSSF 731
>sp|Q01118|SCN7A_HUMAN Sodium channel protein type 7 subunit alpha
OS=Homo sapiens OX=9606 GN=SCN7A PE=1 SV=2
Length=1682
Score = 340 bits (872), Expect = 2e-99, Method: Composition-based stats.
Identities = 104/686 (15%), Positives = 248/686 (36%), Gaps = 88/686 (13%)
Query 61 SINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
S+ AS + C + + F + + D+ +
Sbjct 906 SLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ--RKT 963
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
L E +++ +F ++ +K +G+ + N W VV++V + +
Sbjct 964 IKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLI-GKTREE 1022
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+PL + LRP +L MK ++ + + +V L+ + +F++ G+ LFAG
Sbjct 1023 LKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGS 300
+++ + + N ++++ + + F +G+
Sbjct 1083 R------------FYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGN 1130
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQ 360
FL L A F G++ + +++ + + FEV M F P
Sbjct 1131 GFLSLLQVA----TFNGWIT-IMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPL 1185
Query 361 NLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSV-VKEHPPRPEYQS 419
++L V +D+ +K K++ GS + + +K + L + + P P +
Sbjct 1186 SML---ITVIIDNFNKH----KIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLN 1238
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
+ F+ + ++ +++ + + + + L +N +F++
Sbjct 1239 KLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSI-----ALYWINSIFVML 1293
Query 480 YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
Y +E +LK+ A Y + N+FD ++++ I+ L + P
Sbjct 1294 YTMECILKLIAFR-CFYFTIAWNIFDF----MVVIFSITGLCLPMTVGSYLVPP------ 1342
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
+ +++ + + LR+ K+ + ++ + + ++ +V +++A+ G+
Sbjct 1343 --SLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMY 1400
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL 659
F V N +NF+ F +++ L+ + + W L
Sbjct 1401 NFAYVKKEAGIND--------------------VSNFETFGNSMLCLFQVAIFAGWDGML 1440
Query 660 DAY---------RRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILENFL 698
DA P +++ YFV + L+S +I VN+++ +++E FL
Sbjct 1441 DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVME-FL 1499
Query 699 HKWDPRSHLQPLAGTPEATYQMTVEL 724
+ + + +Q+
Sbjct 1500 NIASKKKNKTLSEDDFRKFFQVWKRF 1525
Score = 174 bits (442), Expect = 8e-44, Method: Composition-based stats.
Identities = 66/469 (14%), Positives = 152/469 (32%), Gaps = 59/469 (13%)
Query 308 TAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
T S + +L ++S + + ++ S + +NL
Sbjct 794 TLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEI 853
Query 368 KVQL-DSSHKQAMMEKVRSYGS--VLLSAEEFQKLFNELDRSVVKEHPPRPE-------- 416
+ + D K+ + + S S + +EE + + +K R
Sbjct 854 QSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGA 913
Query 417 -----YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGI 471
++ + + +F L+ L + ++ D + + +L
Sbjct 914 SKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFE---DIYMDQRKTIKILLEY 970
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
+ +F ++LEMLLK A G + Y S D ++ +V + I
Sbjct 971 ADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIG------------- 1017
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
+ + L + R LR++ + M VV ++ + ++++
Sbjct 1018 -------KTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWL 1070
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGS-------APCGSFEQLEYWAN---NFDDFAA 641
+F+I+G++LF G +S S F + W N NFD+
Sbjct 1071 IFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGN 1130
Query 642 ALVTLWNLMVVNNWQVFLDAYRRYS----------GPWSKIYFVLWWLVSSVIWVNLFLA 691
++L + N W +++ + YF+ + + + +++ +
Sbjct 1131 GFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLIT 1190
Query 692 LILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
+I++NF + ++ L + + P L +
Sbjct 1191 VIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNK 1239
Score = 166 bits (419), Expect = 6e-41, Method: Composition-based stats.
Identities = 97/660 (15%), Positives = 191/660 (29%), Gaps = 104/660 (16%)
Query 78 YSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFA 137
+ L F + L + S W P T L ++
Sbjct 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLT----NLPKWRPVLENT------LLGIYT 156
Query 138 ADLSVKGYLFGWA----HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF 193
++ VK + G F + W V V ++ L L+ R LR
Sbjct 157 FEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVI--IRYSPLDFIPTLQTARTLRIL 214
Query 194 FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLT 253
++ + +K + + L ++ V +L L +F++ GM LF G + +
Sbjct 215 KIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQEN 274
Query 254 YFQNLPESLTSLLVLLTTANNPDVMIPAY----------------------SKNRAYAIF 291
+ L + + T N + Y N
Sbjct 275 ENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG-- 332
Query 292 FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS------------------LFRRRLG 333
F F G L L + + L S + LG
Sbjct 333 FTNFDSFGWA-LFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLG 391
Query 334 -TRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
A+E VGE + + LQ + + + M ++ L
Sbjct 392 ILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLD 451
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQ----------SPFLQSAQFLFGHYYFDYLGNLIA 442
E L ++ + K+ P Y+ SP + +L
Sbjct 452 VLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFL 511
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
+ ++ FL L+ +++ + +L I N VFI + EM+ K+ A+ GY N
Sbjct 512 IICIILNVCFLTLE-HYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWN 570
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
+FD ++ L+ L+ +L + + R ++
Sbjct 571 IFDSMIVFHGLIEL--------------------CLANVAGMALLRLFRMLRIFKLGKYW 610
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
++ ++ ++ +L + A G+ LF
Sbjct 611 PTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGK-----------NYEEFVCH 659
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS 682
QL W + DF + + ++ ++ + D W ++++ L+ +
Sbjct 660 IDKDCQLPRWHMH--DFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGN 717
Score = 99.4 bits (246), Expect = 5e-20, Method: Composition-based stats.
Identities = 60/370 (16%), Positives = 116/370 (31%), Gaps = 78/370 (21%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ ++ + H +F + L + CVF+ L LP R +L +
Sbjct 105 NCIRRTTIKVLVHPFFQLFILISVLID----CVFMSLT--NLPKWRP-----VLENTLLG 153
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E+L+K+FA G+ +L P N D +TV +++
Sbjct 154 IYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVII------------------- 194
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
S D L R L+IIP + + + ++ ++ + + + +F+
Sbjct 195 --RYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFS 252
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
+IG+ LF G +
Sbjct 253 LIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTD 312
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ G + + NFD F AL L+ LM + +V SG I
Sbjct 313 AGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMI 372
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEE 732
+FV+ + S +LFL ++ + + + ++ +
Sbjct 373 FFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAK 432
Query 733 PGEDELTERL 742
+ E+ +R
Sbjct 433 TIQIEMKKRS 442
Score = 85.5 bits (210), Expect = 1e-15, Method: Composition-based stats.
Identities = 33/247 (13%), Positives = 81/247 (33%), Gaps = 12/247 (5%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
R + + + I + + L ++ +
Sbjct 491 WLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLE----HYPMSKQTNTLLNIGNLVFIG 546
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+F A++ K + + W + +++ L++ ++ ++ LR+ R+LR F
Sbjct 547 IFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLA-NVAGMALLRLFRMLRIFK 605
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK-----QDDGQDR 249
L + + + + S + + LLL + FGM LF D +
Sbjct 606 LGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQ 665
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFFIVFTVIGSLFLMNLLT 308
+ + S ++ +L + + +++ I F + ++ L+ L
Sbjct 666 LPRWHMHDFFHSFLNVFRILCGE-WVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLF 724
Query 309 AIIYSQF 315
+ S F
Sbjct 725 LALVSSF 731
>sp|F1LQQ7|SCN7A_RAT Sodium channel protein type 7 subunit alpha
OS=Rattus norvegicus OX=10116 GN=Scn7a PE=1 SV=4
Length=1680
Score = 328 bits (840), Expect = 3e-95, Method: Composition-based stats.
Identities = 105/652 (16%), Positives = 232/652 (36%), Gaps = 91/652 (14%)
Query 68 ASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTES 127
S R C + + + F + + D+ + E
Sbjct 912 ESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQ--RKTIKIFLEY 969
Query 128 VEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWT--VSLSLVCHEPLR 185
+++ +F ++ +K +G+ + N W +V++V + L ++
Sbjct 970 GDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIK 1029
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
R LR MK L+ + + SV L+ + LF++ G+ LFAG
Sbjct 1030 FLRALRVL---SQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGK---- 1082
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+++ + + + N ++++ + + F +G+ FL
Sbjct 1083 --------FYECIDPTRGERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSL 1134
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
A F G++ + +++ + + +FE M F P +L
Sbjct 1135 FQVA----TFNGWI-SIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCML-- 1187
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSV-VKEHPPRPEYQSPFLQS 424
V + + +KQ K++ GS + + +K + L + + P ++ F
Sbjct 1188 -IGVIIRNFNKQ----KIKQGGSNIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGF 1242
Query 425 AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM 484
+ H F+ + L+ +I + D + + + +N +F + + LE
Sbjct 1243 ICDVVTHRVFNVIIILLICFQATTIMI----QNDEQSPQIETAVF-WMNSLFTMLFTLEC 1297
Query 485 LLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
+LK+ A Y + NV D +++V I+ L + + P +
Sbjct 1298 ILKLTAFR-CHYFTSAWNVHDF----MVVVFSITGLLLPLSIGQYFVPP--------SLV 1344
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
++L + + LR K+ + ++ + + ++ +V +++AI G+ F V
Sbjct 1345 QLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV 1404
Query 605 IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY-- 662
N +NF+ F ++++ L+ + + W LDA
Sbjct 1405 KKEAGIND--------------------VSNFETFGSSMLCLFQVTTFSGWDGMLDAIFN 1444
Query 663 -------RRYSGPWSKI------------YFVLWWLVSSVIWVNLFLALILE 695
P +++ YFV + L+S +I VN+++ LI+E
Sbjct 1445 SQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVVLIME 1496
Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats.
Identities = 52/356 (15%), Positives = 124/356 (35%), Gaps = 43/356 (12%)
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA 457
+ V + ++ + + +F+ L+ L ++ + D
Sbjct 899 GYERKSSAGQVSRESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALE---DI 955
Query 458 DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEI 517
+ + L + +F ++LEMLLK A G + Y S D ++ +VL + I
Sbjct 956 YIDQRKTIKIFLEYGDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLI 1015
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ L + R LR++ + M VV ++
Sbjct 1016 G--------------------KTREDLNPLASIKFLRALRVLSQFERMKVVLRALIKTTL 1055
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS-----SLAPANGSAPCGS--FEQLE 630
+ + ++++ +F+++G+ LF G + S+ + C + F +
Sbjct 1056 PAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRGERFSVFEVMNKSQCENLVFNESM 1115
Query 631 YWAN---NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWS----------KIYFVLW 677
W N NFD+ ++L+ + N W +++ G + YF+++
Sbjct 1116 PWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIF 1175
Query 678 WLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ + + + + +I+ NF + + + ++ L ++P
Sbjct 1176 VVFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADSQKP 1231
Score = 156 bits (393), Expect = 9e-38, Method: Composition-based stats.
Identities = 100/680 (15%), Positives = 205/680 (30%), Gaps = 125/680 (18%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ L +F +L L + T S L + W T L ++
Sbjct 108 RRAVIKVLVHPLFRLLILISVLTDSILMCMS----NLPEWILAVENT------LLGIYTF 157
Query 139 DLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ VK G G F +LW V + L+ + LS + + R LR
Sbjct 158 EILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPM--FKTIRTLRILK 215
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
++ + ++ + + L ++ L L + ++FGM LF G + +
Sbjct 216 IIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDG 275
Query 255 FQNLPESLTSLLVLLTTANN--------------------PDVMIPAYSKNRAYAIFFIV 294
+ S +L N + F
Sbjct 276 NDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTS 335
Query 295 FTVIG-----------------------------------------SLFLMNLLTAIIYS 313
F G + ++ +L I+
Sbjct 336 FDNFGWALLAMFRLMTQDYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTM 395
Query 314 QFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDS 373
+ + S R + ++ V GA + ++ + LD
Sbjct 396 AYEQEKQR---ASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIEMKKRSPTSINTTLDI 452
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
A+ K S E + + + P + F A + H
Sbjct 453 LEDTALGHKEEPETSRK---ECPLCWYKFTKTCFIWKCSPCWIKLNEF---ADRIITHPL 506
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
FD + + N+ + + +E +L I N VFI Y +EM+LK+ A+
Sbjct 507 FDLFLVICIILNICFLALE-----HFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHP 561
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
GY ++FD +L V+ L LL+ + + +L+
Sbjct 562 YGYFQISWHIFDSILVVLGL--------------------TEMLLADIEEITVF-ILVPL 600
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
F+++ + + + ++ ++ + Y A+ G+ LF
Sbjct 601 IFIKLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCV---- 656
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIY 673
C + + + DF A VT++ ++ + + W +
Sbjct 657 ---------CHVDQDCQRQRWHMSDFLHAYVTVFRILCGEWIETLWECMEVAGEAWCIPF 707
Query 674 FVLWWLVSSVIWVNLFLALI 693
+++ L+ +++ + LF+AL+
Sbjct 708 YMMVILIGNLLILYLFVALV 727
Score = 89.0 bits (219), Expect = 9e-17, Method: Composition-based stats.
Identities = 56/370 (15%), Positives = 112/370 (30%), Gaps = 78/370 (21%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
S ++ + H F L + L + + +C + ++IL + N +
Sbjct 105 SSLRRAVIKVLVHPLFRLLILISVLTDSILMC----------MSNLPEWILAVEN-TLLG 153
Query 479 YYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
Y E+L+KV A G+ +L N D +T+ E+
Sbjct 154 IYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLF---------------------EL 192
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ S M + R L+IIP + + T++ ++ + + + V +
Sbjct 193 ITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSS 252
Query 595 IIGINLFRGVIVALP------------------------------------------GNS 612
+ G+ LF G +
Sbjct 253 LFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTD 312
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ G + +FD+F AL+ ++ LM + ++ SG I
Sbjct 313 AGLCPEGYMCVKEGSNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQILYASGKIYMI 372
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEE 732
+FVL + +LFL ++ + + S + E E
Sbjct 373 FFVLISFWFAFYMASLFLGILTMAYEQEKQRASEESRDMDSKCHQTVKEFEEEHEGAEME 432
Query 733 PGEDELTERL 742
+ E+ +R
Sbjct 433 TTQIEMKKRS 442
Score = 76.3 bits (186), Expect = 7e-13, Method: Composition-based stats.
Identities = 34/246 (14%), Positives = 92/246 (37%), Gaps = 14/246 (6%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
+ R ++ +F + + I + E L ++ +
Sbjct 491 WIKLNEFADRIITHPLFDLFLVICIILNICFLALE----HFPMSEELMSLLAIGNLVFIG 546
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ ++ +K + + W + +++V+ L + L+ + + I L
Sbjct 547 IYTIEMILKIIAMHPYGYFQISWHIFDSILVVLGLTEML--LADIEEITVFILVPLIFIK 604
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD-----GQDR 249
L + + K ++ + +L + + LL++I + +FGM LF +D +
Sbjct 605 LGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQ 664
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK-NRAYAIFF-IVFTVIGSLFLMNLL 307
+ + + + ++ +L + + A+ I F ++ +IG+L ++ L
Sbjct 665 RQRWHMSDFLHAYVTVFRILCGE-WIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLF 723
Query 308 TAIIYS 313
A++ S
Sbjct 724 VALVSS 729
>sp|P91645|CAC1A_DROME Voltage-dependent calcium channel type
A subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=cac
PE=1 SV=3
Length=1851
Score = 328 bits (841), Expect = 4e-95, Method: Composition-based stats.
Identities = 128/691 (19%), Positives = 261/691 (38%), Gaps = 84/691 (12%)
Query 71 MWLYRRYYSNVCQRTLSFT--IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
W + + + T+ + ++ L F+ T A Y +
Sbjct 423 FWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNT----VCVAVEHYGQPSFLTE--FLYYA 476
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC---HEPLR 185
E + L +F +++ +K Y G + ++ + VV+ S+ + S LR
Sbjct 477 EFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLR 536
Query 186 IRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
RLLR F + + S ++ + + S+ + S+ LL + + +F + GM LF G
Sbjct 537 ALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLP 596
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY------SKNRAYAIFFIVFTVIG 299
G E T F P +L ++ +LT + +VM K Y+I+FIV + G
Sbjct 597 GGTPE--TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFG 654
Query 300 SLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKP 359
+ L+N+ AI A E+ ++ + + +
Sbjct 655 NYTLLNVFLAIAVDNLAN-------------------AQELTAAEEEQVEEDKEKQLQEL 695
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVK-EHPPRPEYQ 418
+ ++ LQ + + + +S G ++ ++ E + ++
Sbjct 696 EKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPT 755
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+P + A ++ YFD+ ++ + ++ L + V R + IL + F
Sbjct 756 NPIRRGAHWVVNLPYFDFFIMVVISMSSIA----LAAEDPVRENSRRNKILNYFDYAFTG 811
Query 479 YYLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ +EMLLK+ LG YL N+ D ++ + V G+
Sbjct 812 VFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVS------------FGFDMSG 859
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ L +L V R L+ I + + V V+ ++N+ + ++ ++F+
Sbjct 860 SSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFS 919
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY-----------WANNFDDFAAAL 643
+IG+ LF G S A +E+ E A ++D+ AAA+
Sbjct 920 VIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAM 979
Query 644 VTLWNLMVVNNW----QVFLDAYRRYSGP------WSKIYFVLWWLVSSVIWVNLFLALI 693
+TL+ + W Q + A GP I+++++++V +VN+F+ALI
Sbjct 980 LTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALI 1039
Query 694 LENFLHKWDPRSHLQPLAGTPEATYQMTVEL 724
+ F + + + G + + ++
Sbjct 1040 IITFQEQGEA----ELQDGEIDKNQKSCIDF 1066
Score = 311 bits (796), Expect = 3e-89, Method: Composition-based stats.
Identities = 115/690 (17%), Positives = 240/690 (35%), Gaps = 129/690 (19%)
Query 125 TESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-V 179
E E L +F + S+K G + + +N+W + V+V + + V
Sbjct 73 LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEV 132
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR R+LRP L+ ++ LK I ++ + +GLL+ + +F + G+ ++
Sbjct 133 DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYS 192
Query 240 GGKQDDGQDRE----------------------------------------------RLT 253
G E +T
Sbjct 193 GALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGIT 252
Query 254 YFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA-----YAIFFIVFTVIGSLFLMNLLT 308
F N+ ++ ++ +T ++ Y N A I+F+ VIGS F++NL+
Sbjct 253 SFDNIGFAMLTVFQCITMEGWTAIL---YWTNDALGSAFNWIYFVPLIVIGSFFMLNLVL 309
Query 309 AIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLS--SMVGEGGAFPQAVGVK-------P 359
++ +F + + RR + F + +MV QA V
Sbjct 310 GVLSGEFSNERNR-----VERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERTTE 364
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNE--LDRSVVKEHPPRPEY 417
+ + +++ + +++ ++ + +S + E + ++ L + +
Sbjct 365 EEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFW 424
Query 418 QS--PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
++ F + +F + ++ N V + V L L +
Sbjct 425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTE-----FLYYAEFI 479
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F+ ++ EM +K++ALG R Y N FD + + + E+ V
Sbjct 480 FLGLFMSEMFIKMYALGPRIYFESSFNRFDC-VVISGSIFEVIWSEVKGG---------- 528
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+ L++L R LRI K + + + V+ L+ +MR+ +L +++ I
Sbjct 529 --------SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILI 580
Query 596 I---GINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
G+ LF G G NF+ F AL+T++ ++
Sbjct 581 FALLGMQLFGGQFNLPGGTPE--------------------TNFNTFPIALLTVFQILTG 620
Query 653 NNWQVFLDAY-----RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
+W + G IYF++ L + +N+FLA+ ++N + + +
Sbjct 621 EDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE 680
Query 708 QPLAGTPEATYQMTVELLFRDILEEPGEDE 737
+ + +E + + E
Sbjct 681 EEQVEEDKEKQLQELEKEMEALQADGVHVE 710
Score = 149 bits (375), Expect = 2e-35, Method: Composition-based stats.
Identities = 65/368 (18%), Positives = 133/368 (36%), Gaps = 58/368 (16%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCVF 476
+P + +F+ F+Y L +++ CV L L+ + ++ L F
Sbjct 25 NPIRKYTRFIIEWPPFEYA----VLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
Query 477 IVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
+ + +E LK+ ALGL YL N+ D + V +
Sbjct 81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM------------------ 122
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R L + V R L+++ + + VV +++ + + G +++ +
Sbjct 123 TQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVI 182
Query 593 FAIIGINLFRGVI--------------------VALPGNSSLAPANGSAPCGS------- 625
FAIIG+ + G + ++ L A GS C +
Sbjct 183 FAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLE 242
Query 626 -FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-WSKIYFVLWWLVSSV 683
+E +FD+ A++T++ + + W L G ++ IYFV ++ S
Sbjct 243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSF 302
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELT-ERL 742
+NL L ++ F ++ + T + + D + + E L ER
Sbjct 303 FMLNLVLGVLSGEFSNERNRVERRMEFQKCRFRAMFQTAMVSYLDWITQAEEVILAEERT 362
Query 743 SQHPHLWL 750
++ + +
Sbjct 363 TEEEKMHI 370
>sp|D0E0C2|SCNA1_PERAM Sodium channel protein PaFPC1 OS=Periplaneta
americana OX=6978 PE=1 SV=1
Length=1553
Score = 323 bits (827), Expect = 2e-93, Method: Composition-based stats.
Identities = 119/694 (17%), Positives = 254/694 (37%), Gaps = 90/694 (13%)
Query 69 SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV 128
SS+ VC F A + S L + D+ P +T V
Sbjct 836 SSVQRMWSNIRRVCFLLAKNKYFQKFVTAVLVITSVLLALEDIYLPQRPVL--VNITLYV 893
Query 129 EVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-CHEPLRIR 187
+ + F ++ + + G+ + + W +V+V L+++ + + + + LR+
Sbjct 894 DYVLTAFFVIEMIIMLFAVGFKKYFTSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLL 953
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+ R F L + M+ + ++P + +V L+ +F + G+ LFAG
Sbjct 954 RVFRLFRPLSKVNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGK------ 1007
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
+++ + E+ T L +T N +N + + F +G+ +L L
Sbjct 1008 ------FYKCVDENSTVLSHEITMDRN-----DCLHENYTWENSPMNFDHVGNAYLSLLQ 1056
Query 308 TAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
A F+G+L + + ++ R + + E M F +L++
Sbjct 1057 VA----TFKGWL-QIMNDAIDSREVHKQPIRETNIYMYLYFIFFIVF---GSFFILKLFV 1108
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ +D +Q + ++ G + + R++ + R + QS +
Sbjct 1109 CILIDIFRQQ----RRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCHPQSLMY 1164
Query 428 LFG-HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
+ F+Y ++ + N V ++ + +L LN +FI+ + +E ++
Sbjct 1165 DISVNRKFEYTMMILIILN-----VAVMAIDHYGQSMEFSEVLDYLNLIFIIIFFVECVI 1219
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
KV L Y P N+ D L +VL I+ L + + + + R+
Sbjct 1220 KVSGLR-HHYFKDPWNIIDFL----YVVLAIAGLMLSDVIEKYFISPTL--------LRI 1266
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L +L V R LR S + M ++ + ++ + +L V+ +V+A+ G+ F +
Sbjct 1267 LRILRVGRLLRYFQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGMEFFMHIRD 1326
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL------- 659
A + NF F +++ L+ L W
Sbjct 1327 AGAIDD--------------------VYNFKTFGQSIILLFQLATSAGWDGVYFAIANEE 1366
Query 660 -----DAYRRYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
D Y G Y V + +++ ++ +N++ A+IL+ L ++ +
Sbjct 1367 DCRAPDHELGYPGNCGSRALGIAYLVSYLIITCLVVINMYAAVILDYVLEVYED--SKEG 1424
Query 710 LAGTPEATYQMTVELLFRDILEEPGEDELTERLS 743
L + + + + D+L+E L
Sbjct 1425 LTDDDYDMFFEVWQQFDPEATQYIRYDQLSELLE 1458
Score = 276 bits (707), Expect = 1e-77, Method: Composition-based stats.
Identities = 109/668 (16%), Positives = 230/668 (34%), Gaps = 60/668 (9%)
Query 91 FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWA 150
F LF+A I + D +E + + + ++ + +K
Sbjct 520 FFELFIAVIIVLNITFMALDHHDMNIEFE---RILRTGNYIFTSIYIVEAVLKIIALSPK 576
Query 151 HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIR 210
+ K+ W + +++V ++++ + + R RLLR F L + + + +
Sbjct 577 FYFKDSWNVFDFIIVVFAILELGLE-GVQGLSVFRSFRLLRVFRLAKFWPTLNNFMSVMT 635
Query 211 WSLPEMASVGLLLAIHLCLFTMFGMLLFA----GGKQDDGQDRERLTYFQNLPESLTSLL 266
S +V ++ + L +F + GM LF + F + S +
Sbjct 636 KSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNMERFPDGDLPRWNFTDFLHSFMIVF 695
Query 267 VLLTTANNPDVMIPAYSKNRAYAI-FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQT 325
L + M I FF+ +G+L ++NLL A++ + + +
Sbjct 696 RALCGE-WIESMWDCMLVGDWSCIPFFVAVFFVGNLVILNLLIALLLNNYGSFCTSPTSD 754
Query 326 SLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRS 385
+ + + P VK + + + + +
Sbjct 755 EEDSKDEDA-----LAQIVRIFKRFKPNLNAVKLSPMKPDSEDIVESQEIQGNNIADAED 809
Query 386 YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ---SPFLQSAQFLFGHYYFDYLGNLIA 442
+ + N + Q S + L + YF +
Sbjct 810 VLAGEFPPD---CCCNAFYKCFPSRPARDSSVQRMWSNIRRVCFLLAKNKYFQKFVTAVL 866
Query 443 LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSN 502
+ V + + D + I ++ V ++++EM++ +FA+G + Y +
Sbjct 867 VITSVLLALE---DIYLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYFTSKWY 923
Query 503 VFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
D ++ V L+ + A + + L +L VFR R + +
Sbjct 924 WLDFIVVVAYLLNFVLMCAGI------------------EALQTLRLLRVFRLFRPLSKV 965
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPG-NSSLAPANGSA 621
M VV ST++ V ++ + + + VFAI+G+ LF G NS++ +
Sbjct 966 NGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAIMGVQLFAGKFYKCVDENSTVLSHEITM 1025
Query 622 PCGSFEQLEY-WAN---NFDDFAAALVTLWNLMVVNNW-QVFLDAY---------RRYSG 667
Y W N NFD A ++L + W Q+ DA R +
Sbjct 1026 DRNDCLHENYTWENSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHKQPIRETN 1085
Query 668 PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
+ +YF+ + + S + LF+ ++++ F + R + L+ T T + + R
Sbjct 1086 IYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQ---RRKAEGLSATDSRTQLIYRRAVMR 1142
Query 728 DILEEPGE 735
+ +P +
Sbjct 1143 TMSAKPVK 1150
Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats.
Identities = 96/630 (15%), Positives = 200/630 (32%), Gaps = 127/630 (20%)
Query 120 PPCGLTESVEVLCLLVFAADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS 175
P T +E++ L ++ ++ VK G++ + ++ W +V ++ + T+
Sbjct 160 PATQTTYILELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYI--TLV 217
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
+ L LR R+LR + + + + + S+ + + LLL L +F + G+
Sbjct 218 VDLGHLYALRAFRVLRSWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFSLFVFAVLGL 277
Query 236 LLFAG-------------GKQDDGQDRERLTYFQN------------------------- 257
++ G G + D Y N
Sbjct 278 QIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSSGAGMC 337
Query 258 -----------------------LPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI-FFI 293
+ S+ L+T D+ A + I FFI
Sbjct 338 PPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLALRSAGPWHILFFI 397
Query 294 VFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ 353
+ G+ +N + A++ + ++ + + E ++ V A Q
Sbjct 398 IVVFYGTFCFLNFILAVVVMSY----THMVKRADEEKAAERELKKEKKAASVANNTANGQ 453
Query 354 AVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPP 413
+ + V +D++ + A + + ++ L ++
Sbjct 454 EQTTI---EMNGDEAVVIDNNDQAARQQSDPETPAPSVTQRLTDFLCVWDCCVPWQK--- 507
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILN 473
+ + +F+ +I + N F+ LD + E + IL N
Sbjct 508 -------LQGAIGAVVLSPFFELFIAVIIVLN----ITFMALDHHDMNIEFER-ILRTGN 555
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
+F Y++E +LK+ AL + Y NVFD ++ V ++
Sbjct 556 YIFTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVVFAILEL----------------- 598
Query 534 MVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVF 593
L + + R R+ + S + ++ ++ ++F
Sbjct 599 ---GLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMSVMTKSYGAFVNVMYVMFLLLFIF 655
Query 594 AIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVN 653
AIIG+ LF N F + NF DF + + ++ +
Sbjct 656 AIIGMQLFG--------------MNYIDNMERFPDGDLPRWNFTDFLHSFMIVFRALCGE 701
Query 654 NWQVFLDAYRRYSGPWSKI-YFVLWWLVSS 682
W + G WS I +FV + V +
Sbjct 702 -WIESMWDCM-LVGDWSCIPFFVAVFFVGN 729
Score = 120 bits (301), Expect = 2e-26, Method: Composition-based stats.
Identities = 62/348 (18%), Positives = 123/348 (35%), Gaps = 81/348 (23%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVY 479
P + A F Y + L + C+F+++ A IL VF+
Sbjct 128 PIRRVAISTMVQPIFSYFIMITILIH----CIFMIMPATQTT--------YILELVFLSI 175
Query 480 YLLEMLLKVFALG----LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
Y +E+++KV A G YL P N D L+T++ + + L
Sbjct 176 YTIEVVVKVLARGFILHPFAYLRDPWNWLDFLVTLIGYITLVVDLGHLYA---------- 225
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
L V R R + + + + + +++ +L+ +VFA+
Sbjct 226 -----------LRAFRVLRSWRTVTIVPGWRTIVDALSLSITSLKDLVLLLLFSLFVFAV 274
Query 596 IGINLFRGVI----------------------------------------VALPGNSS-- 613
+G+ ++ GV+ L GNSS
Sbjct 275 LGLQIYMGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYPLCGNSSGA 334
Query 614 -LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ P + G Y +FD F A ++++ L+ ++ W+ R +GPW +
Sbjct 335 GMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFLSVFRLVTLDYWEDLYQLALRSAGPWHIL 394
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
+F++ + ++N LA+++ ++ H R+ + A +
Sbjct 395 FFIIVVFYGTFCFLNFILAVVVMSYTHMVK-RADEEKAAERELKKEKK 441
>sp|Q9P0X4|CAC1I_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1I OS=Homo sapiens OX=9606 GN=CACNA1I PE=1 SV=1
Length=2223
Score = 279 bits (714), Expect = 1e-78, Method: Composition-based stats.
Identities = 101/661 (15%), Positives = 230/661 (35%), Gaps = 89/661 (13%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ +CQ ++ +F + LAFI + + A + +F
Sbjct 1158 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGS--TERIFLTVSNYIFTAIF 1215
Query 137 AADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLR 191
++++K G FG + ++ W + ++ VS++D VSL S + L + R+LR
Sbjct 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
Query 192 PFFL------LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ + +K ++ + SL + ++ L+ +F + G+ LF G
Sbjct 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGK---- 1331
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
++ L ++ N D M N + F +G LM+
Sbjct 1332 --------FYHCLGVDTRNIT------NRSDCMAA----NYRWVHHKYNFDNLGQA-LMS 1372
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L + + + L + + M+ +F + +L +
Sbjct 1373 LFVLASKDGW----VNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL---IVSFFVLNM 1425
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
V +++ HK ++ L + + P
Sbjct 1426 FVGVVVENFHKCRQHQEAEEARRREEKR-----LRRLEKKRRKAQRLPYYATYCHTRLLI 1480
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
+ +Y D I N+V++ + + L N +F ++LE +
Sbjct 1481 HSMCTSHYLDIFITFIICLNVVTMSLE-----HYNQPTSLETALKYCNYMFTTVFVLEAV 1535
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LK+ A GLR + N D + +++L + + + + P + R
Sbjct 1536 LKLVAFGLRRFFKDRWNQLD----LAIVLLSVMGITLEEIEINAALPI------NPTIIR 1585
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++ +L + R L+++ M + TV+ + + G + +++++++A +G+ LF ++
Sbjct 1586 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV 1645
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ + F++F A +TL+ + +NW + R
Sbjct 1646 ---------------CNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD 1690
Query 666 SGP-----------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
S +YFV + L + + +N+ +A+++++ +
Sbjct 1691 CTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEL 1750
Query 715 E 715
E
Sbjct 1751 E 1751
Score = 217 bits (552), Expect = 1e-57, Method: Composition-based stats.
Identities = 64/298 (21%), Positives = 118/298 (40%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
++ F Q + H FDY+ N ++I + + + L + N +
Sbjct 1154 SPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALE---RPQIEAGSTERIFLTVSNYI 1210
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F ++ EM LKV +LGL + YL NV DG L V ++ + +LA
Sbjct 1211 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGV 1270
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + +V T++ ++ + I +
Sbjct 1271 LRVLRLLRTLRPLRV------------ISRAPGLKLVVETLISSLKPIGNIVLICCAFFI 1318
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + N S + + + NFD+ AL++L+ L
Sbjct 1319 IFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLAS 1378
Query 652 VNNWQVFLDAYRRY----------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + PW +YF+ + L+ S +N+F+ +++ENF
Sbjct 1379 KDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1436
Score = 200 bits (509), Expect = 4e-52, Method: Composition-based stats.
Identities = 67/325 (21%), Positives = 122/325 (38%), Gaps = 42/325 (13%)
Query 428 LFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ YF+ + L N VS + ++ P E + IL I N VF + LEM+LK
Sbjct 636 IVDSKYFNRGIMMAILVNTVS----MGIEHHEQPEELTN-ILEICNVVFTSMFALEMILK 690
Query 488 VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
+ A GL YL P N + + + + R
Sbjct 691 LAAFGLFDYLRNPYN-----------------IFDSIIVIISIWEIVGQADGGLSVLRTF 733
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
+L V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G+++F
Sbjct 734 RLLRVLKLVRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL 790
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG 667
P NFD A+VT++ ++ +W V L +
Sbjct 791 RTDTGDTVPD---------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS 835
Query 668 PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE--ATYQMTVELL 725
PW+ +YFV + + NL +A+++E F + D + + E L
Sbjct 836 PWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGL 895
Query 726 FRDILEEPGEDELTERLSQHPHLWL 750
+ +T P L L
Sbjct 896 DSSGDPKLCPIPMTPNGHLDPSLPL 920
Score = 134 bits (336), Expect = 1e-30, Method: Composition-based stats.
Identities = 52/293 (18%), Positives = 110/293 (38%), Gaps = 32/293 (11%)
Query 77 YYSNVCQRTLSFTIF-----LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVL 131
YY+ C L L +F+ FI + +T + Y + +
Sbjct 1469 YYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL-EHYNQPTSLE--TALKYCNYM 1525
Query 132 CLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHE 182
VF + +K FG F K+ W L ++++S++ T+ ++
Sbjct 1526 FTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIR 1585
Query 183 PLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK 242
+R+ R+ R LL+ ++ M+ L + +LP++ ++GLL + ++ G+ LF
Sbjct 1586 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV 1645
Query 243 QDD---GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------------AYSKNRA 287
+D + R F+N + +L + T N +M S
Sbjct 1646 CNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFV 1705
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEV 340
++F+ F + L+N++ A++ ++ + + L A +
Sbjct 1706 SPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGL 1758
Score = 131 bits (330), Expect = 5e-30, Method: Composition-based stats.
Identities = 45/248 (18%), Positives = 98/248 (40%), Gaps = 9/248 (4%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
R + + F + I + + + E V+
Sbjct 626 WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELT--NILEICNVVFTS 681
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+FA ++ +K FG + +N + + + +V+ + V + LR RLLR
Sbjct 682 MFALEMILKLAAFGLFDYLRNPYNIFDSI-IVIISIWEIVGQADGGLSVLRTFRLLRVLK 740
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ---DDGQDRER 251
L++ +++ L + ++ +A+ +LL + + +F++ GM +F D G
Sbjct 741 LVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPD 800
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
F +L ++ ++ +LT + V+ S + +++F+ G+ L NLL AI
Sbjct 801 RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAI 860
Query 311 IYSQFRGY 318
+ F+
Sbjct 861 LVEGFQAE 868
Score = 93.6 bits (231), Expect = 4e-18, Method: Composition-based stats.
Identities = 42/318 (13%), Positives = 102/318 (32%), Gaps = 61/318 (19%)
Query 138 ADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ +K FG + + W +++ +V++++ L + +R R+LRP
Sbjct 128 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ M+ + + +LP + +V LL +F + G+ L+AG ++ E T
Sbjct 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTI 247
Query 255 FQNL-------PESLTSLLVLLTTANNPDVM----------------------------- 278
++ PE + + + + + +M
Sbjct 248 QGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGR 307
Query 279 ------IPAYSKNRAYAIF----------FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ NR Y + I F IG + + G++ +
Sbjct 308 QDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAW----IVIFQVITLEGWV-EI 362
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEK 382
+ + + +L +VG + V + Q+ ++
Sbjct 363 MYYVMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS 421
Query 383 VRSYGSVLLSAEEFQKLF 400
+ S + ++++F
Sbjct 422 SSTVASYAEPGDCYEEIF 439
Score = 75.1 bits (183), Expect = 2e-12, Method: Composition-based stats.
Identities = 37/185 (20%), Positives = 76/185 (41%), Gaps = 23/185 (12%)
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
+ + +F+ + L+ L N V++ ++ D D+ IL + + +++
Sbjct 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCD-DMDCLSDRCKILQVFDDFIFIFFA 127
Query 482 LEMLLKVFALGLRG---YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+EM+LK+ ALG+ G YL N D + + +V L L
Sbjct 128 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA----------- 176
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + V R L+ I + M ++ + +L + + + V+++F IIG+
Sbjct 177 --------IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
Query 599 NLFRG 603
L+ G
Sbjct 229 QLWAG 233
Score = 74.0 bits (180), Expect = 5e-12, Method: Composition-based stats.
Identities = 21/88 (24%), Positives = 36/88 (41%), Gaps = 1/88 (1%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTV 722
F + R H L TV
Sbjct 399 TQFS-ETKQREHRLMLEQRQRYLSSSTV 425
>sp|Q9Z0Y8|CAC1I_RAT Voltage-dependent T-type calcium channel
subunit alpha-1I OS=Rattus norvegicus OX=10116 GN=Cacna1i PE=1
SV=3
Length=2201
Score = 278 bits (712), Expect = 3e-78, Method: Composition-based stats.
Identities = 100/661 (15%), Positives = 231/661 (35%), Gaps = 89/661 (13%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ +CQ ++ +F + LAFI + + A + +F
Sbjct 1117 KFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGS--TERIFLTVSNYIFTAIF 1174
Query 137 AADLSVK----GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLR 191
++++K G FG + ++ W + ++ VS++D VS+ S + L + R+LR
Sbjct 1175 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLR 1234
Query 192 PFFL------LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ + +K ++ + SL + ++ L+ +F + G+ LF G
Sbjct 1235 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGK---- 1290
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
++ L ++ N D + N + F +G LM+
Sbjct 1291 --------FYHCLGVDTRNIT------NRSDC----VAANYRWVHHKYNFDNLGQA-LMS 1331
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L + + + L + + M+ +F + +L +
Sbjct 1332 LFVLASKDGW----VNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL---IVSFFVLNM 1384
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
V +++ HK ++ L + + P P
Sbjct 1385 FVGVVVENFHKCRQHQEAEEARRREEKR-----LRRLEKKRRKAQRLPYYATYCPTRLLI 1439
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
+ +Y D I N+V++ + + L N +F ++LE +
Sbjct 1440 HSMCTSHYLDIFITFIICLNVVTMSLE-----HYNQPTSLETALKYCNYMFTTVFVLEAV 1494
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LK+ A GLR + N D + +++L + + + + P + R
Sbjct 1495 LKLVAFGLRRFFKDRWNQLD----LAIVLLSVMGITLEEIEINAALPI------NPTIIR 1544
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++ +L + R L+++ M + TV+ + + G + +++++++A +G+ LF ++
Sbjct 1545 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV 1604
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ + F++F A +TL+ + +NW + R
Sbjct 1605 ---------------CNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD 1649
Query 666 SGP-----------WSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
S +YFV + L + + +N+ +A+++++ +
Sbjct 1650 CTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEI 1709
Query 715 E 715
E
Sbjct 1710 E 1710
Score = 216 bits (550), Expect = 3e-57, Method: Composition-based stats.
Identities = 63/298 (21%), Positives = 118/298 (40%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
++ F Q + H FDY+ N ++I + + + L + N +
Sbjct 1113 SPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALE---RPQIEAGSTERIFLTVSNYI 1169
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F ++ EM LKV +LGL + YL NV DG L V ++ + ++A
Sbjct 1170 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGV 1229
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + +V T++ ++ + I +
Sbjct 1230 LRVLRLLRTLRPLRV------------ISRAPGLKLVVETLISSLKPIGNIVLICCAFFI 1277
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + N S + + + NFD+ AL++L+ L
Sbjct 1278 IFGILGVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKYNFDNLGQALMSLFVLAS 1337
Query 652 VNNWQVFLDAYRRY----------SGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + PW +YF+ + L+ S +N+F+ +++ENF
Sbjct 1338 KDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1395
Score = 199 bits (507), Expect = 6e-52, Method: Composition-based stats.
Identities = 61/293 (21%), Positives = 114/293 (39%), Gaps = 40/293 (14%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ + + YF+ + L N VS + ++ P E + IL I N VF
Sbjct 585 RETREKLRGIVDSKYFNRGIMMAILVNTVS----MGIEHHEQPEELTN-ILEICNVVFTS 639
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ LEM+LK+ A GL YL P N + + +
Sbjct 640 MFALEMILKLAAFGLFDYLRNPYN-----------------IFDSIIVIISIWEIVGQAD 682
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ R +L V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G+
Sbjct 683 GGLSVLRTFRLLRVLKLVRFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGM 739
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
++F P NFD A+VT++ ++ +W V
Sbjct 740 HIFGCKFSLRTDTGDTVPD---------------RKNFDSLLWAIVTVFQILTQEDWNVV 784
Query 659 LDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLA 711
L + PW+ +YFV + + NL +A+++E F + D
Sbjct 785 LYNGMASTTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDED 837
Score = 132 bits (332), Expect = 4e-30, Method: Composition-based stats.
Identities = 50/291 (17%), Positives = 110/291 (38%), Gaps = 34/291 (12%)
Query 77 YYSNVC------QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEV 130
YY+ C + +L +F+ FI + +T + Y +
Sbjct 1428 YYATYCPTRLLIHSMCTSH-YLDIFITFIICLNVVTMSL-EHYNQPTSLE--TALKYCNY 1483
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCH 181
+ VF + +K FG F K+ W L ++++S++ T+ ++
Sbjct 1484 MFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTII 1543
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
+R+ R+ R LL+ ++ M+ L + +LP++ ++GLL + ++ G+ LF
Sbjct 1544 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKL 1603
Query 242 KQDD---GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP------------AYSKNR 286
+D + R F+N + +L + T N +M S
Sbjct 1604 VCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQF 1663
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
++F+ F + L+N++ A++ ++ + + + A
Sbjct 1664 VSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMA 1714
Score = 131 bits (330), Expect = 5e-30, Method: Composition-based stats.
Identities = 45/248 (18%), Positives = 97/248 (39%), Gaps = 9/248 (4%)
Query 75 RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
R + + F + I + + + E V+
Sbjct 584 WRETREKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELT--NILEICNVVFTS 639
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
+FA ++ +K FG + +N + + + +V+ + V + LR RLLR
Sbjct 640 MFALEMILKLAAFGLFDYLRNPYNIFDSI-IVIISIWEIVGQADGGLSVLRTFRLLRVLK 698
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ---DDGQDRER 251
L++ +++ L + ++ +A+ +LL + + +F++ GM +F D G
Sbjct 699 LVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPD 758
Query 252 LTYFQNLPESLTSLLVLLTTANNPDVMIPAY-SKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
F +L ++ ++ +LT + V+ S +++F+ G+ L NLL AI
Sbjct 759 RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVALMTFGNYVLFNLLVAI 818
Query 311 IYSQFRGY 318
+ F+
Sbjct 819 LVEGFQAE 826
Score = 94.0 bits (232), Expect = 3e-18, Method: Composition-based stats.
Identities = 42/318 (13%), Positives = 96/318 (30%), Gaps = 61/318 (19%)
Query 138 ADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFF 194
++ +K FG + + W +++ +V++++ L + +R R+LRP
Sbjct 126 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 185
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLT- 253
+ M+ + + +LP + +V LL +F + G+ L+AG ++ E T
Sbjct 186 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTI 245
Query 254 --------YFQNLPESLTSLLVLLTTAN-------------------------------- 273
Y+Q + + LT N
Sbjct 246 QGDVALPPYYQPEEDDEMPFICSLTGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGR 305
Query 274 -----------NPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ N I F IG + + G++ +
Sbjct 306 QDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAW----IVIFQVITLEGWV-EI 360
Query 323 LQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEK 382
+ + + +L +VG + V + Q+ ++
Sbjct 361 MYYVMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS 419
Query 383 VRSYGSVLLSAEEFQKLF 400
+ S + ++++F
Sbjct 420 SSTVASYAEPGDCYEEIF 437
Score = 74.8 bits (182), Expect = 2e-12, Method: Composition-based stats.
Identities = 37/185 (20%), Positives = 77/185 (42%), Gaps = 23/185 (12%)
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL 481
+ + +F+ + L+ L N V++ ++ D ++R IL + + +++
Sbjct 67 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCK-ILQVFDDFIFIFFA 125
Query 482 LEMLLKVFALGLRG---YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+EM+LK+ ALG+ G YL N D + + +V L L
Sbjct 126 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA----------- 174
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ + V R L+ I + M ++ + +L + + + V+++F IIG+
Sbjct 175 --------IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 226
Query 599 NLFRG 603
L+ G
Sbjct 227 QLWAG 231
Score = 74.0 bits (180), Expect = 5e-12, Method: Composition-based stats.
Identities = 21/88 (24%), Positives = 36/88 (41%), Gaps = 1/88 (1%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 337 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 396
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTV 722
F + R H L TV
Sbjct 397 TQFS-ETKQREHRLMLEQRQRYLSSSTV 423
>sp|O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Homo sapiens OX=9606 GN=CACNA1H PE=1 SV=4
Length=2353
Score = 278 bits (711), Expect = 4e-78, Method: Composition-based stats.
Identities = 111/702 (16%), Positives = 227/702 (32%), Gaps = 91/702 (13%)
Query 10 PLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDAS 69
P R G R AA D D + + ++
Sbjct 1211 PTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSRE 1270
Query 70 SMWLY----RRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
+ LY + + CQ+ ++ +F + L FI + P
Sbjct 1271 AWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDID--PGSTERVFL 1328
Query 126 ESVEVLCLLVFAADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVC 180
+ +F A++ VK G + ++ W L ++++VSLVD V++ S
Sbjct 1329 SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGG 1388
Query 181 HEPLRIRRLLRPFFL------LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
+ L + R+LR + + +K ++ + SL + ++ L+ +F + G
Sbjct 1389 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILG 1448
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
+ LF G R N + + +
Sbjct 1449 VQLFKGKFYYCEGPDTR----------------------NISTKAQCRAAHYRWVRRKYN 1486
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
F +G LM+L + + + L + + M+ +F
Sbjct 1487 FDNLGQA-LMSLFVLSSKDGW----VNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL- 1540
Query 355 VGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPR 414
+ +L + V +++ HK + + E R
Sbjct 1541 --IVSFFVLNMFVGVVVENFHK-CRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRR 1597
Query 415 PEYQ--SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGIL 472
P Y SP +S L +Y D I N++++ + + D L
Sbjct 1598 PYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSME-----HYNQPKSLDEALKYC 1652
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
N VF + ++ E LK+ A G R + N D + +++L + + + + P
Sbjct 1653 NYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLD----LAIVLLSLMGITLEEIEMSAALP 1708
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R++ +L + R L+++ M + TV+ + + G + ++++++
Sbjct 1709 I------NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1762
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
+A +G+ LF + + F +F A +TL+ +
Sbjct 1763 YAALGVELFG---------------RLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTG 1807
Query 653 NNWQVFLDAYRRYSG-----------PWSKIYFVLWWLVSSV 683
+NW + R S +YFV + LV+
Sbjct 1808 DNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQF 1849
Score = 224 bits (570), Expect = 6e-60, Method: Composition-based stats.
Identities = 82/360 (23%), Positives = 142/360 (39%), Gaps = 51/360 (14%)
Query 396 FQKLFNELDRSVVKEHPPRPEYQSP----FLQSAQFLFGHYYFDYLGNLIALANLVSICV 451
+ R+ + P P + F + + YF + L N +S
Sbjct 753 GPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLS--- 809
Query 452 FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
+ ++ P E + L I N VF + LEMLLK+ A G GY+ P N+FDG++ V
Sbjct 810 -MGVEYHEQPEELTN-ALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIV-V 866
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ V EI A + R +L V + +R +P+++ VV
Sbjct 867 ISVWEIVGQA----------------DGGLSVLRTFRLLRVLKLVRFLPALRRQLVV--- 907
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
++ + N+ F +L++ ++F+I+G++LF P
Sbjct 908 LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPD-------------- 953
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
NFD A+VT++ ++ +W V L + W+ +YFV + + NL +A
Sbjct 954 -RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVA 1012
Query 692 LILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTER-LSQHPHLWL 750
+++E F + D + T E + E F L E EL L+ P+ L
Sbjct 1013 ILVEGFQAEGDANR-----SDTDEDKTSVHFEEDFHK-LRELQTTELKMCSLAVTPNGHL 1066
Score = 216 bits (551), Expect = 2e-57, Method: Composition-based stats.
Identities = 68/298 (23%), Positives = 123/298 (41%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
Q+ F S Q + H FD++ + N V+I + D+ P + L + N +
Sbjct 1278 SPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALE---RPDIDPGSTERVFLSVSNYI 1334
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F ++ EM++KV ALGL YL N+ DGLL +V LV + +A
Sbjct 1335 FTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGV 1394
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + +V T++ ++ + I +
Sbjct 1395 LRVLRLLRTLRPLRV------------ISRAPGLKLVVETLISSLRPIGNIVLICCAFFI 1442
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + + + + + NFD+ AL++L+ L
Sbjct 1443 IFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSS 1502
Query 652 VNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + G PW +YF+ + L+ S +N+F+ +++ENF
Sbjct 1503 KDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1560
Score = 148 bits (374), Expect = 2e-35, Method: Composition-based stats.
Identities = 49/252 (19%), Positives = 102/252 (40%), Gaps = 9/252 (4%)
Query 71 MWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEV 130
M +S +R + F + I + + E +
Sbjct 775 MGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELT--NALEISNI 830
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLL 190
+ +FA ++ +K G + +N + + +++V+S V V + LR RLL
Sbjct 831 VFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLL 889
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG---KQDDGQ 247
R L++ +++ L + ++ +A+ LL + + +F++ GM LF K D G
Sbjct 890 RVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGD 949
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFIVFTVIGSLFLMNL 306
F +L ++ ++ +LT + V+ + ++ A++F+ G+ L NL
Sbjct 950 TVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNL 1009
Query 307 LTAIIYSQFRGY 318
L AI+ F+
Sbjct 1010 LVAILVEGFQAE 1021
Score = 130 bits (327), Expect = 1e-29, Method: Composition-based stats.
Identities = 47/284 (17%), Positives = 109/284 (38%), Gaps = 28/284 (10%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ +L LF+ FI + +T + Y + + +VF
Sbjct 1607 RRSIHSLCTSH-YLDLFITFIICVNVITMSM-EHYNQPKSLDEA--LKYCNYVFTIVFVF 1662
Query 139 DLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHEPLRIRRL 189
+ ++K FG+ F K+ W L ++++SL+ T+ ++ +R+ R+
Sbjct 1663 EAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRI 1722
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ---DDG 246
R LL+ ++ M+ L + +LP++ ++GLL + ++ G+ LF + +
Sbjct 1723 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPC 1782
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA------------YAIFFIV 294
+ R F N + +L + T N +M + ++F+
Sbjct 1783 EGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVT 1842
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAF 338
F ++ L+N++ A++ ++ + + + A
Sbjct 1843 FVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1886
Score = 95.9 bits (237), Expect = 8e-19, Method: Composition-based stats.
Identities = 52/385 (14%), Positives = 113/385 (29%), Gaps = 70/385 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
VC L++ L + DV + C + E+ +
Sbjct 92 WCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP-CEDVECGSER----CNILEAFDAFIFAF 146
Query 136 FAADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP 192
FA ++ +K FG + + W ++V ++++++ V +R R+LRP
Sbjct 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERL 252
+ M+ + + +LP + +V LL +F + G+ L+AG ++
Sbjct 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Query 253 TYFQNLPESLTSLLVLLTTANNPDVM---------------------------IPAYSKN 285
NL L NP + AY++
Sbjct 267 VRNNNLTF-LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQP 325
Query 286 RA------------YAIFF--------------IVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+A + ++ I F IG ++ G++
Sbjct 326 QAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVI----TLEGWV 381
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
+ + + +L +VG + V + K + ++
Sbjct 382 -DIMYYVMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSET--KQRESQLMREQR 437
Query 380 MEKVRSYGSVLLSAEEFQKLFNELD 404
+ + ++ +E L
Sbjct 438 ARHLSNDSTLASFSEPGSCYEELLK 462
Score = 83.6 bits (205), Expect = 5e-15, Method: Composition-based stats.
Identities = 50/253 (20%), Positives = 102/253 (40%), Gaps = 28/253 (11%)
Query 387 GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANL 446
G+ L + EE + + L +V +S L+ L + +F+++ L+ + N
Sbjct 59 GAELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLR----LVCNPWFEHVSMLVIMLNC 114
Query 447 VSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG---YLSYPSNV 503
V++ +F + +ER + IL + ++ +EM++K+ ALGL G YL N
Sbjct 115 VTLGMFRPCEDVECGSERCN-ILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNR 173
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
D + ++ + Y L + + V R LR I +
Sbjct 174 LDFFIV-------VAGMMEYSLDGHNVSLS------------AIRTVRVLRPLRAINRVP 214
Query 564 LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-VALPGNSSLAPANGSAP 622
M ++ + +L + + + V+++F I+G+ L+ G++ +S+ N
Sbjct 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTF 274
Query 623 CGSFEQLEYWANN 635
+ Q E N
Sbjct 275 LRPYYQTEEGEEN 287
Score = 75.5 bits (184), Expect = 1e-12, Method: Composition-based stats.
Identities = 18/73 (25%), Positives = 32/73 (44%), Gaps = 0/73 (0%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 419
Query 695 ENFLHKWDPRSHL 707
F S L
Sbjct 420 TQFSETKQRESQL 432
>sp|O54898|CAC1G_RAT Voltage-dependent T-type calcium channel
subunit alpha-1G OS=Rattus norvegicus OX=10116 GN=Cacna1g PE=1
SV=2
Length=2254
Score = 274 bits (700), Expect = 9e-77, Method: Composition-based stats.
Identities = 107/639 (17%), Positives = 233/639 (36%), Gaps = 83/639 (13%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ +C R ++ +F + L I + + E + VF
Sbjct 1243 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI--FLTLSNYIFTAVF 1300
Query 137 AADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLR 191
A+++VK GW + ++ W + +++++S++D VS+ S + L + R+LR
Sbjct 1301 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1360
Query 192 PFF------LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
++ + +K ++ + SL + ++ ++ +F + G+ LF G
Sbjct 1361 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1420
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+ R N D +Y + F +G LM+
Sbjct 1421 QGEDTR------------------NITNKSDCAEASY----RWVRHKYNFDNLGQA-LMS 1457
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L + + + L + + M+ +F + +L +
Sbjct 1458 LFVLASKDGW----VDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL---IVAFFVLNM 1510
Query 366 LQKVQLDSSHK--QAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
V +++ HK Q E+ +K ++ + + P S F
Sbjct 1511 FVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRL 1570
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
L +Y D + N+V++ + + D L I N +F V ++ E
Sbjct 1571 LVHHLCTSHYLDLFITGVIGLNVVTMAME-----HYQQPQILDEALKICNYIFTVIFVFE 1625
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+ K+ A G R + N D + +++L I + + + P +
Sbjct 1626 SVFKLVAFGFRRFFQDRWNQLD----LAIVLLSIMGITLEEIEVNLSLPI------NPTI 1675
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
R++ +L + R L+++ M + TV+ + + G + ++++++FA +G+ LF
Sbjct 1676 IRIMRVLRIARVLKLLKMAVGMRALLHTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1735
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL---- 659
+ + PC + F +F A +TL+ + +NW +
Sbjct 1736 -----------LECDETHPCEGLGRHAT----FRNFGMAFLTLFRVSTGDNWNGIMKDTL 1780
Query 660 -DAYRR---YSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
D + Y+ S IYFV + L + + VN+ +A+++
Sbjct 1781 RDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1819
Score = 213 bits (541), Expect = 3e-56, Method: Composition-based stats.
Identities = 64/298 (21%), Positives = 121/298 (41%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
QS F + H FD++ +I N ++I + + P + L + N +
Sbjct 1239 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAME---RPKIDPHSAERIFLTLSNYI 1295
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F +L EM +KV ALG + YL NV DGLL ++ ++ + ++
Sbjct 1296 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1355
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + + +V T++ ++ + I +
Sbjct 1356 LRVLRLLRTLRPLRV------------ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFI 1403
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + N S + + NFD+ AL++L+ L
Sbjct 1404 IFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLAS 1463
Query 652 VNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + G PW +YF+ + L+ + +N+F+ +++ENF
Sbjct 1464 KDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK 1521
Score = 213 bits (541), Expect = 3e-56, Method: Composition-based stats.
Identities = 68/340 (20%), Positives = 132/340 (39%), Gaps = 43/340 (13%)
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP--EYQSPFLQSAQFLF 429
D + E V + ++ RS+ + P + + + +
Sbjct 682 DHVMPDSDSEAVYEFTQDAQHSDLRDPHSRRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 741
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
YF + L N +S + ++ P E + L I N VF + LEMLLK+
Sbjct 742 DSKYFGRGIMIAILVNTLS----MGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLL 796
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
G GY+ P N+FDG++ V+ V EI + R +
Sbjct 797 VYGPFGYIKNPYNIFDGVIV-VISVWEIVGQQG----------------GGLSVLRTFRL 839
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G++LF +
Sbjct 840 MRVLKLVRFLPALQRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 896
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+L NFD A+VT++ ++ +W L + W
Sbjct 897 DGDTLPD----------------RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSW 940
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
+ +YF+ + + NL +A+++E F + D
Sbjct 941 AALYFIALMTFGNYVLFNLLVAILVEGFQAEGDATKSESE 980
Score = 151 bits (381), Expect = 4e-36, Method: Composition-based stats.
Identities = 55/301 (18%), Positives = 121/301 (40%), Gaps = 11/301 (4%)
Query 24 AGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDA---IQYRSINHRVDASSMWLYRRYYSN 80
+ + + A ++ D + D + RS+ + SS+ + R +
Sbjct 676 GEPESADHVMPDSDSEAVYEFTQDAQHSDLRDPHSRRRQRSLGPDAEPSSVLAFWRLICD 735
Query 81 VCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
++ + F + I + + E ++ +FA ++
Sbjct 736 TFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELT--NALEISNIVFTSLFALEM 791
Query 141 SVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSS 200
+K ++G + KN + + V++V+S V V LR RL+R L++
Sbjct 792 LLKLLVYGPFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 850
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK--QDDGQDRERLTYFQNL 258
+++ L + ++ +A+ +LL + + +F++ GM LF + DG F +L
Sbjct 851 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSL 910
Query 259 PESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
++ ++ +LT + V+ + ++ A++FI G+ L NLL AI+ F+
Sbjct 911 LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQA 970
Query 318 Y 318
Sbjct 971 E 971
Score = 100 bits (249), Expect = 3e-20, Method: Composition-based stats.
Identities = 61/439 (14%), Positives = 126/439 (29%), Gaps = 76/439 (17%)
Query 16 RGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR 75
G GG G T A + V F + S
Sbjct 26 SGAGGRQGPGSTEKDPGSADSEAEGLPYPALAPVVFFY------------LSQDSRPRSW 73
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
VC L++ L + D+ + C + ++ +
Sbjct 74 -CLRTVCNPWFERVSMLVILLNCVTLGMFRP-CEDIACDSQR----CRILQAFDDFIFAF 127
Query 136 FAADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP 192
FA ++ VK FG + + W +++ ++++++ L V +R R+LRP
Sbjct 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERL 252
+ M+ + + +LP + +V LL +F + G+ L+AG ++ E
Sbjct 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Query 253 T---------YFQNLP-------------ESLTSLLVLLTTAN---------------NP 275
+ Y+Q + S + T N
Sbjct 248 SLPLSVDLEPYYQTENEDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCSLDYETYNS 307
Query 276 DVMIPAYSKNRAY-------AIFF---IVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQT 325
+ N+ Y F I F IG ++ G++ +
Sbjct 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVI----TLEGWV-DIMYF 362
Query 326 SLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRS 385
+ + +L +VG + V + K + ++ + + +
Sbjct 363 VMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSET--KQRESQLMREQRVRFLSN 419
Query 386 YGSVLLSAEEFQKLFNELD 404
++ +E L
Sbjct 420 ASTLASFSEPGSCYEELLK 438
Score = 78.6 bits (192), Expect = 2e-13, Method: Composition-based stats.
Identities = 47/222 (21%), Positives = 85/222 (38%), Gaps = 27/222 (12%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
S + +F+ + L+ L N V++ +F + D+ + IL +
Sbjct 68 SRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCE-DIACDSQRCRILQAFDDFIFA 126
Query 479 YYLLEMLLKVFALGLRG---YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
++ +EM++K+ ALG+ G YL N D + I+ + Y L V
Sbjct 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAV 179
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+ V R LR I + M ++ + +L + + + V+++F I
Sbjct 180 ------------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 227
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
+G+ L+ G L N P N S P + Y N D
Sbjct 228 VGVQLWAG----LLRNRCFLPENFSLPLSVDLEPYYQTENED 265
Score = 75.1 bits (183), Expect = 2e-12, Method: Composition-based stats.
Identities = 22/108 (20%), Positives = 39/108 (36%), Gaps = 3/108 (3%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERL 742
F S L + L +EL + L
Sbjct 396 TQFSETKQRES---QLMREQRVRFLSNASTLASFSEPGSCYEELLKYL 440
>sp|O43497|CAC1G_HUMAN Voltage-dependent T-type calcium channel
subunit alpha-1G OS=Homo sapiens OX=9606 GN=CACNA1G PE=1 SV=3
Length=2377
Score = 273 bits (699), Expect = 1e-76, Method: Composition-based stats.
Identities = 106/650 (16%), Positives = 233/650 (36%), Gaps = 94/650 (14%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ +C R ++ +F + L I + + E + VF
Sbjct 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI--FLTLSNYIFTAVF 1321
Query 137 AADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLR 191
A+++VK GW + ++ W + +++++S++D VS+ S + L + R+LR
Sbjct 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
Query 192 PFF------LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
++ + +K ++ + SL + ++ ++ +F + G+ LF G
Sbjct 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+ R N D +Y + F +G LM+
Sbjct 1442 QGEDTR------------------NITNKSDCAEASY----RWVRHKYNFDNLGQA-LMS 1478
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L + + + L + + M+ +F + +L +
Sbjct 1479 LFVLASKDGW----VDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL---IVAFFVLNM 1531
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVL-------------LSAEEFQKLFNELDRSVVKEHP 412
V +++ HK ++ L ++ + + +
Sbjct 1532 FVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCK 1591
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGIL 472
P S F L +Y D + N+V++ + + D L I
Sbjct 1592 PYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME-----HYQQPQILDEALKIC 1646
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
N +F V ++LE + K+ A G R + N D + +++L I + + + P
Sbjct 1647 NYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLD----LAIVLLSIMGITLEEIEVNASLP 1702
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+ R++ +L + R L+++ M + TV+ + + G + ++++++
Sbjct 1703 I------NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFI 1756
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
FA +G+ LF + + PC + F +F A +TL+ +
Sbjct 1757 FAALGVELFGD-----------LECDETHPCEGLGRHAT----FRNFGMAFLTLFRVSTG 1801
Query 653 NNWQVFL-----DAYRR---YSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+NW + D + Y+ S IYFV + L + + VN+ +A+++
Sbjct 1802 DNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1851
Score = 214 bits (544), Expect = 1e-56, Method: Composition-based stats.
Identities = 64/298 (21%), Positives = 121/298 (41%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
QS F + H FD++ +I N ++I + + P + L + N +
Sbjct 1260 PPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAME---RPKIDPHSAERIFLTLSNYI 1316
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F +L EM +KV ALG + YL NV DGLL ++ ++ + ++
Sbjct 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + + +V T++ ++ + I +
Sbjct 1377 LRVLRLLRTLRPLRV------------ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFI 1424
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + N S + + NFD+ AL++L+ L
Sbjct 1425 IFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLAS 1484
Query 652 VNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + G PW +YF+ + L+ + +N+F+ +++ENF
Sbjct 1485 KDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK 1542
Score = 213 bits (543), Expect = 2e-56, Method: Composition-based stats.
Identities = 64/309 (21%), Positives = 127/309 (41%), Gaps = 43/309 (14%)
Query 394 EEFQKLFNELDRSVVKEHPPRP--EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICV 451
+ + + RS+ + P + + + + YF + L N +S
Sbjct 703 SDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLS--- 759
Query 452 FLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
+ ++ P E + L I N VF + LEMLLK+ G GY+ P N+FDG++ V
Sbjct 760 -MGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIV-V 816
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ V EI + R ++ V + +R +P+++ VV
Sbjct 817 ISVWEIVGQQG----------------GGLSVLRTFRLMRVLKLVRFLPALQRQLVV--- 857
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
++ + N+ F +L++ ++F+I+G++LF + +L
Sbjct 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPD--------------- 902
Query 632 WANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLA 691
NFD A+VT++ ++ +W L + W+ +YF+ + + NL +A
Sbjct 903 -RKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVA 961
Query 692 LILENFLHK 700
+++E F +
Sbjct 962 ILVEGFQAE 970
Score = 155 bits (391), Expect = 2e-37, Method: Composition-based stats.
Identities = 60/333 (18%), Positives = 129/333 (39%), Gaps = 19/333 (6%)
Query 8 SEPLLGGARGGGGD---------WPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIED--A 56
S P L G G + + A ++ D + D +
Sbjct 651 SSPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHS 710
Query 57 IQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAA 116
+ RS+ + SS+ + R + ++ + F + I + +
Sbjct 711 RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQP 768
Query 117 PWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSL 176
E ++ +FA ++ +K ++G + KN + + V++V+S V V
Sbjct 769 EELT--NALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVIS-VWEIVGQ 825
Query 177 SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
LR RL+R L++ +++ L + ++ +A+ +LL + + +F++ GM
Sbjct 826 QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH 885
Query 237 LFAGGK--QDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFI 293
LF + DG F +L ++ ++ +LT + V+ + ++ A++FI
Sbjct 886 LFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query 294 VFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTS 326
G+ L NLL AI+ F+ + + +
Sbjct 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDA 978
Score = 99.0 bits (245), Expect = 9e-20, Method: Composition-based stats.
Identities = 59/439 (13%), Positives = 120/439 (27%), Gaps = 76/439 (17%)
Query 16 RGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYR 75
G GG G A + V F + S
Sbjct 26 SGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFY------------LSQDSRPRSW 73
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
VC L++ L + D+ + C + ++ +
Sbjct 74 -CLRTVCNPWFERISMLVILLNCVTLGMFRP-CEDIACDSQR----CRILQAFDDFIFAF 127
Query 136 FAADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP 192
FA ++ VK FG + + W +++ ++++++ L V +R R+LRP
Sbjct 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG------ 246
+ M+ + + +LP + +V LL +F + G+ L+AG ++
Sbjct 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENF 247
Query 247 -----QDRERLTYFQNLPESLTSLLV---------------------------------- 267
D ER +N ES
Sbjct 248 SLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNS 307
Query 268 --LLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQT 325
T N + I F IG ++ G++ +
Sbjct 308 SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVI----TLEGWV-DIMYF 362
Query 326 SLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRS 385
+ + +L +VG + V + K + ++ + + +
Sbjct 363 VMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSET--KQRESQLMREQRVRFLSN 419
Query 386 YGSVLLSAEEFQKLFNELD 404
++ +E L
Sbjct 420 ASTLASFSEPGSCYEELLK 438
Score = 78.2 bits (191), Expect = 2e-13, Method: Composition-based stats.
Identities = 41/215 (19%), Positives = 81/215 (38%), Gaps = 23/215 (11%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
S + +F+ + L+ L N V++ +F + D+ + IL +
Sbjct 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCE-DIACDSQRCRILQAFDDFIFA 126
Query 479 YYLLEMLLKVFALGLRG---YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
++ +EM++K+ ALG+ G YL N D + I+ + Y L V
Sbjct 127 FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAGMLEYSLDLQNVSFSAV 179
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+ V R LR I + M ++ + +L + + + V+++F I
Sbjct 180 ------------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 227
Query 596 IGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
+G+ L+ G++ S + Q E
Sbjct 228 VGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTE 262
Score = 75.5 bits (184), Expect = 2e-12, Method: Composition-based stats.
Identities = 22/108 (20%), Positives = 39/108 (36%), Gaps = 3/108 (3%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERL 742
F S L + L +EL + L
Sbjct 396 TQFSETKQRES---QLMREQRVRFLSNASTLASFSEPGSCYEELLKYL 440
>sp|O88427|CAC1H_MOUSE Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Mus musculus OX=10090 GN=Cacna1h PE=1
SV=3
Length=2365
Score = 273 bits (697), Expect = 3e-76, Method: Composition-based stats.
Identities = 107/676 (16%), Positives = 222/676 (33%), Gaps = 91/676 (13%)
Query 36 PGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLY----RRYYSNVCQRTLSFTIF 91
AA D D + ++ + S LY + CQ+ ++ +F
Sbjct 1248 EDAAEFDDDIEDSCCFRLHKVLEPYAPQWCSSRESWALYLFPPQNRLRVSCQKVIAHKMF 1307
Query 92 LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW-- 149
+ L FI + P + +F ++ VK G
Sbjct 1308 DHVVLVFIFLNCITIALERPDID--PGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLW 1365
Query 150 --AHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLRPFFL------LQNSS 200
+ ++ W + ++++VSLVD V++ S + L + R+LR + +
Sbjct 1366 GEHAYLQSSWNVLDGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1425
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPE 260
+K ++ + SL + ++ L+ +F + G+ LF G
Sbjct 1426 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEG------------- 1472
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
T N ++ + + F +G LM+L + +
Sbjct 1473 ---------TDTRNITTKAECHAAHYRWVRRKYNFDNLGQA-LMSLFVLSSKDGW----V 1518
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM 380
+ L + + M+ +F + +L + V +++ HK
Sbjct 1519 NIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLL---IVSFFVLNMFVGVVVENFHK-CRQ 1574
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ--SPFLQSAQFLFGHYYFDYLG 438
+ + E RP Y S +S L +Y D
Sbjct 1575 HQEAEEARRREEKRLRRLERRRRSTFPNPEAQRRPYYADYSHTRRSIHSLCTSHYLDLFI 1634
Query 439 NLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLS 498
I N++++ + + D L N VF + ++ E LK+ A G R +
Sbjct 1635 TFIICLNVITMSME-----HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFK 1689
Query 499 YPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N D + +++L I +A+ + P + R++ +L + R L++
Sbjct 1690 DRWNQLD----LAIVLLSIMGIALEEIEMNAALPI------NPTIIRIMRVLRIARVLKL 1739
Query 559 IPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
+ M + TV+ + + G + +++++++A +G+ LF
Sbjct 1740 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---------------R 1784
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS-----------G 667
+ + F +F A +TL+ + +NW + R
Sbjct 1785 LECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLP 1844
Query 668 PWSKIYFVLWWLVSSV 683
S +YFV + LV+
Sbjct 1845 ALSPVYFVTFVLVAQF 1860
Score = 221 bits (562), Expect = 7e-59, Method: Composition-based stats.
Identities = 69/314 (22%), Positives = 130/314 (41%), Gaps = 43/314 (14%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ F + + YF+ L N +S + ++ P E + L I N VF
Sbjct 777 ASFSSKLRRIVDSKYFNRGIMAAILVNTLS----MGVEYHEQPDELTN-ALEISNIVFTS 831
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ LEMLLK+ A G GY+ P N+FDG + V++ V EI A
Sbjct 832 MFALEMLLKLLACGPLGYIRNPYNIFDG-IVVIISVWEIVGQA----------------D 874
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ R +L V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G+
Sbjct 875 GGLSVLRTFRLLRVLKLVRFLPALRRQLVV---LMRTMDNVATFCMLLMLFIFIFSILGM 931
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+LF + P NFD A+VT++ ++ +W V
Sbjct 932 HLFGCKFSLKTDSGDTVPD---------------RKNFDSLLWAIVTVFQILTQEDWNVV 976
Query 659 LDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPR---SHLQPLAGTPE 715
L + W+ +YFV + + NL +A+++E F + D + + E
Sbjct 977 LYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTDEDKTSTHLE 1036
Query 716 ATYQMTVELLFRDI 729
+ ++ ++
Sbjct 1037 EDFDKLRDVQATEM 1050
Score = 219 bits (558), Expect = 2e-58, Method: Composition-based stats.
Identities = 68/298 (23%), Positives = 122/298 (41%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
Q+ S Q + H FD++ + N ++I + D+ P + L + N +
Sbjct 1289 PPQNRLRVSCQKVIAHKMFDHVVLVFIFLNCITIALE---RPDIDPGSTERAFLSVSNYI 1345
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F +++EM++KV ALGL YL NV DGLL +V LV I +A
Sbjct 1346 FTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAVASAGGAKILGV 1405
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + +V T++ ++ + I +
Sbjct 1406 LRVLRLLRTLRPLRV------------ISRAPGLKLVVETLISSLRPIGNIVLICCAFFI 1453
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + + + + NFD+ AL++L+ L
Sbjct 1454 IFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQALMSLFVLSS 1513
Query 652 VNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + G PW +YF+ + L+ S +N+F+ +++ENF
Sbjct 1514 KDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1571
Score = 153 bits (387), Expect = 6e-37, Method: Composition-based stats.
Identities = 57/318 (18%), Positives = 119/318 (37%), Gaps = 10/318 (3%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
A +P + GD A + V G + ++R
Sbjct 706 ALEDPEFEFSGSESGDSDAHGVYEFTQDVRHGDCRDPVQQPHEGGTPGHGNERWRPPLRT 765
Query 66 VDA-SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL 124
+ +S+ +R + F +A I + +
Sbjct 766 ASQPGGLGRLWASFSSKLRRIVDSKYFNRGIMAAILVNTLSMGVE--YHEQPDELT--NA 821
Query 125 TESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL 184
E ++ +FA ++ +K G + +N + + +V+++S V V + L
Sbjct 822 LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVIIS-VWEIVGQADGGLSVL 880
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG--- 241
R RLLR L++ +++ L + ++ +A+ +LL + + +F++ GM LF
Sbjct 881 RTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSL 940
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFIVFTVIGS 300
K D G F +L ++ ++ +LT + V+ + ++ A++F+ G+
Sbjct 941 KTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGN 1000
Query 301 LFLMNLLTAIIYSQFRGY 318
L NLL AI+ F+
Sbjct 1001 YVLFNLLVAILVEGFQAE 1018
Score = 127 bits (319), Expect = 1e-28, Method: Composition-based stats.
Identities = 56/375 (15%), Positives = 131/375 (35%), Gaps = 41/375 (11%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ +L LF+ FI + +T + Y + + +VF
Sbjct 1618 RRSIHSLCTSH-YLDLFITFIICLNVITMSM-EHYNQPKSLDEA--LKYCNYVFTIVFVF 1673
Query 139 DLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHEPLRIRRL 189
+ ++K FG+ F K+ W L ++++S++ + ++ +R+ R+
Sbjct 1674 EAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRI 1733
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ---DDG 246
R LL+ ++ M+ L + +LP++ ++GLL + ++ G+ LF + +
Sbjct 1734 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPC 1793
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA------------YAIFFIV 294
+ R F N + +L + T N +M + ++F+
Sbjct 1794 EGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPALSPVYFVT 1853
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
F ++ L+N++ A++ ++ + + + A S ++
Sbjct 1854 FVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEMDAEIELEIAQG---STAQPPSTAQES 1910
Query 355 VGVKPQNLL---------QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDR 405
G +P + + DS + + + L E + +
Sbjct 1911 QGTEPDTPNLLVVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHP-LQEVEMETYTGPVTS 1969
Query 406 SVVKEHPPRPEYQSP 420
+ PR +Q P
Sbjct 1970 AHSPSLEPRTSFQVP 1984
Score = 97.9 bits (242), Expect = 2e-19, Method: Composition-based stats.
Identities = 51/385 (13%), Positives = 111/385 (29%), Gaps = 70/385 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
V +R L++ L + DV R+ C + E+ +
Sbjct 92 WCLRLVSRRWFEHISMLVIMLNCVTLGMFRP-CEDVECRSER----CSILEAFDDFIFAF 146
Query 136 FAADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP 192
FA ++ +K FG + + W +++ ++++++ V +R R+LRP
Sbjct 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERL 252
+ M+ + + +LP + +V LL +F + G+ L+AG ++
Sbjct 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIP-------------------------------- 280
NL L NP +
Sbjct 267 VRNNNLTF-LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQP 325
Query 281 -----------AYSKNRAY----------AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ N+ Y I F IG ++ G++
Sbjct 326 QAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVI----TLEGWV 381
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
+ + + +L +VG + V + K + + ++
Sbjct 382 -DIMYYVMDAHSF-YNFIYFILLIIVGSFFMINLCLVVIATQFSET--KQRENQLMREQR 437
Query 380 MEKVRSYGSVLLSAEEFQKLFNELD 404
+ + ++ +E L
Sbjct 438 ARYLSNDSTLASFSEPGSCYEELLK 462
Score = 84.8 bits (208), Expect = 2e-15, Method: Composition-based stats.
Identities = 50/253 (20%), Positives = 99/253 (39%), Gaps = 28/253 (11%)
Query 387 GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANL 446
G+ L + EE + L +V +S L+ L +F+++ L+ + N
Sbjct 59 GADLGADEEQPVPYPALAATVFFCLGQTTRPRSWCLR----LVSRRWFEHISMLVIMLNC 114
Query 447 VSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG---YLSYPSNV 503
V++ +F + +ER IL + ++ +EM++K+ ALGL G YL N
Sbjct 115 VTLGMFRPCEDVECRSERCS-ILEAFDDFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNR 173
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
D + + + + Y L + + V R LR I +
Sbjct 174 LDFFIVM-------AGMMEYSLDGHNVSLS------------AIRTVRVLRPLRAINRVP 214
Query 564 LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-VALPGNSSLAPANGSAP 622
M ++ + +L + + + V+++F I+G+ L+ G++ +S+ N
Sbjct 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTF 274
Query 623 CGSFEQLEYWANN 635
+ Q E N
Sbjct 275 LRPYYQTEEGEEN 287
Score = 75.9 bits (185), Expect = 1e-12, Method: Composition-based stats.
Identities = 22/106 (21%), Positives = 39/106 (37%), Gaps = 3/106 (3%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L +V S +NL L +I
Sbjct 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 419
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
F + L A Y L +EL +
Sbjct 420 TQFSETKQREN---QLMREQRARYLSNDSTLASFSEPGSCYEELLK 462
>sp|Q9EQ60|CAC1H_RAT Voltage-dependent T-type calcium channel
subunit alpha-1H OS=Rattus norvegicus OX=10116 GN=Cacna1h PE=2
SV=2
Length=2359
Score = 271 bits (694), Expect = 6e-76, Method: Composition-based stats.
Identities = 99/629 (16%), Positives = 210/629 (33%), Gaps = 89/629 (14%)
Query 77 YYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
CQ+ ++ +F + L FI + P + +F
Sbjct 1293 RLRVSCQKVIAHKMFDHVVLVFIFLNCITIALERPDID--PGSTERAFLSVSNYIFTAIF 1350
Query 137 AADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTVSL-SLVCHEPLRIRRLLR 191
++ VK G + ++ W + ++++VSLVD V++ S + L + R+LR
Sbjct 1351 VVEMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAMASAGGAKILGVLRVLR 1410
Query 192 PFFL------LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDD 245
+ + +K ++ + SL + ++ L+ +F + G+ LF G
Sbjct 1411 LLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC 1470
Query 246 GQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
T N ++ + + F +G LM+
Sbjct 1471 EG----------------------TDTRNITTKAECHAAHYRWVRRKYNFDNLGQA-LMS 1507
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
L + + + L + + M+ +F + +L +
Sbjct 1508 LFVLSSKDGW----VNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLL---IVSFFVLNM 1560
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
V +++ HK ++ L R + P S +S
Sbjct 1561 FVGVVVENFHKCRQHQEAEEARRREEKR-----LRRLERRRRKAQRRPYYADYSHTRRSI 1615
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEML 485
L +Y D I N++++ + + D L N VF + ++ E
Sbjct 1616 HSLCTSHYLDLFITFIICLNVITMSME-----HYNQPKSLDEALKYCNYVFTIVFVFEAA 1670
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
LK+ A G R + N D + +++L I +A+ + P + R
Sbjct 1671 LKLVAFGFRRFFKDRWNQLD----LAIVLLSIMGIALEEIEMNAALPI------NPTIIR 1720
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++ +L + R L+++ M + TV+ + + G + +++++++A +G+ LF
Sbjct 1721 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG--- 1777
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ + F +F A +TL+ + +NW + R
Sbjct 1778 ------------RLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRE 1825
Query 666 S-----------GPWSKIYFVLWWLVSSV 683
S +YFV + LV+
Sbjct 1826 CTREDKHCLSYLPALSPVYFVTFMLVAQF 1854
Score = 221 bits (562), Expect = 6e-59, Method: Composition-based stats.
Identities = 71/314 (23%), Positives = 130/314 (41%), Gaps = 43/314 (14%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+ F + + YF+ L N +S + ++ P E + L I N VF
Sbjct 777 ASFSGKLRRIVDSKYFNRGIMAAILVNTLS----MGVEYHEQPEELTN-ALEISNIVFTS 831
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ LEMLLK+ A G GY+ P N+FDG + VV+ V EI A
Sbjct 832 MFALEMLLKLLACGPLGYIRNPYNIFDG-IVVVISVWEIVGQAN---------------- 874
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ R +L V + +R +P+++ VV ++ + N+ F +L++ ++F+I+G+
Sbjct 875 GGLSVLRTFRLLRVLKLVRFLPALRRQLVV---LMRTMDNVATFCMLLMLFIFIFSILGM 931
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
+LF + P NFD A+VT++ ++ +W V
Sbjct 932 HLFGCKFSLKTDSGDTVPD---------------RKNFDSLLWAIVTVFQILTQEDWNVV 976
Query 659 LDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPR---SHLQPLAGTPE 715
L + W+ +YFV + + NL +A+++E F + D + + E
Sbjct 977 LYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSDTDEDKTSTQLE 1036
Query 716 ATYQMTVELLFRDI 729
+ +L ++
Sbjct 1037 GDFDKLRDLRATEM 1050
Score = 219 bits (559), Expect = 2e-58, Method: Composition-based stats.
Identities = 68/298 (23%), Positives = 122/298 (41%), Gaps = 29/298 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
Q+ S Q + H FD++ + N ++I + D+ P + L + N +
Sbjct 1289 PPQNRLRVSCQKVIAHKMFDHVVLVFIFLNCITIALE---RPDIDPGSTERAFLSVSNYI 1345
Query 476 FIVYYLLEMLLKVFALGL----RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
F +++EM++KV ALGL YL NV DGLL +V LV I +A
Sbjct 1346 FTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLVDIIVAMASAGGAKILGV 1405
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYY 591
++ LL R+ I + +V T++ ++ + I +
Sbjct 1406 LRVLRLLRTLRPLRV------------ISRAPGLKLVVETLISSLRPIGNIVLICCAFFI 1453
Query 592 VFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMV 651
+F I+G+ LF+G G + + + + NFD+ AL++L+ L
Sbjct 1454 IFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQALMSLFVLSS 1513
Query 652 VNNWQVFLDAYRRYSG----------PWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ W + G PW +YF+ + L+ S +N+F+ +++ENF
Sbjct 1514 KDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1571
Score = 153 bits (386), Expect = 7e-37, Method: Composition-based stats.
Identities = 59/335 (18%), Positives = 125/335 (37%), Gaps = 11/335 (3%)
Query 6 AESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHR 65
A +P + GD A + V G + + R+ +
Sbjct 706 ALEDPEFEFSGSESGDSDAHGVYEFTQDVRHGDCRDPVQQPHEVGTPGHSNERRRTPLRK 765
Query 66 VDA-SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGL 124
+ +S +R + F +A I + +
Sbjct 766 ASQPGGIGHLWASFSGKLRRIVDSKYFNRGIMAAILVNTLSMGVE--YHEQPEELT--NA 821
Query 125 TESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPL 184
E ++ +FA ++ +K G + +N + + +V+V+S V V + L
Sbjct 822 LEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVIS-VWEIVGQANGGLSVL 880
Query 185 RIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG--- 241
R RLLR L++ +++ L + ++ +A+ +LL + + +F++ GM LF
Sbjct 881 RTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSL 940
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFIVFTVIGS 300
K D G F +L ++ ++ +LT + V+ + ++ A++F+ G+
Sbjct 941 KTDSGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGN 1000
Query 301 LFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
L NLL AI+ F+ + ++ + T+
Sbjct 1001 YVLFNLLVAILVEGFQAEG-DATRSDTDEDKTSTQ 1034
Score = 126 bits (317), Expect = 2e-28, Method: Composition-based stats.
Identities = 45/284 (16%), Positives = 108/284 (38%), Gaps = 28/284 (10%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ +L LF+ FI + +T + Y + + +VF
Sbjct 1612 RRSIHSLCTSH-YLDLFITFIICLNVITMSM-EHYNQPKSLDEA--LKYCNYVFTIVFVF 1667
Query 139 DLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS---------LSLVCHEPLRIRRL 189
+ ++K FG+ F K+ W L ++++S++ + ++ +R+ R+
Sbjct 1668 EAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRI 1727
Query 190 LRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ---DDG 246
R LL+ ++ M+ L + +LP++ ++GLL + ++ G+ LF + +
Sbjct 1728 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPC 1787
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA------------YAIFFIV 294
+ R F N + +L + T N +M + ++F+
Sbjct 1788 EGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECTREDKHCLSYLPALSPVYFVT 1847
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAF 338
F ++ L+N++ A++ ++ + + + A
Sbjct 1848 FMLVAQFVLVNVVVAVLMKHLEESNKEAREDAEMDAEIELEMAQ 1891
Score = 97.1 bits (240), Expect = 3e-19, Method: Composition-based stats.
Identities = 50/385 (13%), Positives = 110/385 (29%), Gaps = 70/385 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
VC L++ L + DV R+ C + E+ +
Sbjct 92 WCLRLVCNPWFEHISMLVIMLNCVTLGMFRP-CEDVECRSER----CSILEAFDDFIFAF 146
Query 136 FAADLSVKGYL---FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP 192
FA ++ +K FG + + W +++ ++++++ V +R R+LRP
Sbjct 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query 193 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERL 252
+ M+ + + +LP + +V LL +F + G+ L+AG ++
Sbjct 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIP-------------------------------- 280
NL L NP +
Sbjct 267 VRNNNLTF-LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQP 325
Query 281 -----------AYSKNRAY----------AIFFIVFTVIGSLFLMNLLTAIIYSQFRGYL 319
+ N+ Y I F IG ++ G++
Sbjct 326 QAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQVI----TLEGWV 381
Query 320 MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAM 379
+ + + +L ++G + V + K + + ++
Sbjct 382 -DIMYYVMDAHSF-YNFIYFILLIIMGSFFMINLCLVVIATQFSET--KQRENQLMREQR 437
Query 380 MEKVRSYGSVLLSAEEFQKLFNELD 404
+ + ++ +E L
Sbjct 438 ARYLSNDSTLASFSEPGSCYEELLK 462
Score = 83.2 bits (204), Expect = 7e-15, Method: Composition-based stats.
Identities = 50/253 (20%), Positives = 100/253 (40%), Gaps = 28/253 (11%)
Query 387 GSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANL 446
G+ L + EE + L +V +S L+ L + +F+++ L+ + N
Sbjct 59 GADLGADEEQPVPYPALAATVFFCLGQTTRPRSWCLR----LVCNPWFEHISMLVIMLNC 114
Query 447 VSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG---YLSYPSNV 503
V++ +F + +ER IL + ++ +EM++K+ ALGL G YL N
Sbjct 115 VTLGMFRPCEDVECRSERCS-ILEAFDDFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNR 173
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
D + + + + Y L + + V R LR I +
Sbjct 174 LDFFIVM-------AGMMEYSLDGHNVSLS------------AIRTVRVLRPLRAINRVP 214
Query 564 LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI-VALPGNSSLAPANGSAP 622
M ++ + +L + + + V+++F I+G+ L+ G++ +S+ N
Sbjct 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTF 274
Query 623 CGSFEQLEYWANN 635
+ Q E N
Sbjct 275 LRPYYQTEEGEEN 287
Score = 75.5 bits (184), Expect = 2e-12, Method: Composition-based stats.
Identities = 21/106 (20%), Positives = 39/106 (37%), Gaps = 3/106 (3%)
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
NFD+ A + ++ ++ + W + ++ IYF+L ++ S +NL L +I
Sbjct 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIMGSFFMINLCLVVIA 419
Query 695 ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTE 740
F + L A Y L +EL +
Sbjct 420 TQFSETKQREN---QLMREQRARYLSNDSTLASFSEPGSCYEELLK 462
>sp|O42398|CAC1S_CHICK Voltage-dependent L-type calcium channel
subunit alpha-1S (Fragment) OS=Gallus gallus OX=9031 GN=CACNA1S
PE=2 SV=1
Length=281
Score = 186 bits (473), Expect = 2e-52, Method: Composition-based stats.
Identities = 59/308 (19%), Positives = 120/308 (39%), Gaps = 45/308 (15%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
+ + +Q E Y + L + Q + L ++ + P ++P+
Sbjct 1 VGFVIVTFQEQGESE----YKNCELDKNQRQCVQYALKARPLRRYIP----KNPYQYQIW 52
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
++ YF+YL + + N + + + + + + ILN F V + LEM+L
Sbjct 53 YVVTSSYFEYLMFFLIMLNTICLGM-----QHYNQSAEMNHVSDILNVAFTVLFTLEMIL 107
Query 487 KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
K+ A +GY P NVFD L+ + ++ I + P+ +S
Sbjct 108 KLMAFKAKGYFGDPWNVFDFLIVIGSIIDVILSEI--------DDPDDNSRVS----ITF 155
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
+ V R ++++ + + + T + Q + ++V++++++A+IG+ +F G I
Sbjct 156 FRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKIA 214
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD--AYRR 664
+ G NNF F A++ L+ WQ L +Y +
Sbjct 215 MVDGT-----------------QINRNNNFQTFPQAVLLLFRCATGEAWQEILLDCSYGK 257
Query 665 YSGPWSKI 672
P S
Sbjct 258 RCDPESDY 265
Score = 105 bits (262), Expect = 8e-24, Method: Composition-based stats.
Identities = 37/203 (18%), Positives = 76/203 (37%), Gaps = 13/203 (6%)
Query 91 FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWA 150
+L+ FL + T Y + + V ++F ++ +K F
Sbjct 62 YLMFFLIMLNTICLGM----QHYNQSAEMNHVSDI--LNVAFTVLFTLEMILKLMAFKAK 115
Query 151 HFQKNLWLLGYLVVLVVSLVDWTVSL-------SLVCHEPLRIRRLLRPFFLLQNSSMMK 203
+ + W + ++++ S++D +S S V R+ R++R LL ++
Sbjct 116 GYFGDPWNVFDFLIVIGSIIDVILSEIDDPDDNSRVSITFFRLFRVMRLVKLLSRGEGVR 175
Query 204 KTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLT 263
L S + V LL+ + ++ + GM +F DG R FQ P+++
Sbjct 176 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVDGTQINRNNNFQTFPQAVL 235
Query 264 SLLVLLTTANNPDVMIPAYSKNR 286
L T ++++ R
Sbjct 236 LLFRCATGEAWQEILLDCSYGKR 258
>sp|Q6Q760|NALCN_RAT Sodium leak channel NALCN OS=Rattus norvegicus
OX=10116 GN=Nalcn PE=1 SV=1
Length=1738
Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats.
Identities = 107/635 (17%), Positives = 222/635 (35%), Gaps = 95/635 (15%)
Query 92 LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-EVLCLLVFAADLSVK----GYL 146
L+ +L ++ ++ S + + + T + E + ++ + +L++K G
Sbjct 884 LVTYLDWVMITVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLF 943
Query 147 FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP----LRIRRLLRPFFLLQNSSMM 202
F ++ + + + +VSL+ V E L + R LRP + + M
Sbjct 944 FTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQM 1003
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-KQDDGQDRERLTYFQNLPES 261
+K ++ + E+ V +LL + +F FG+ LFAG + + + R +
Sbjct 1004 RKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI 1063
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
S+ L P P + R +A F +G+ L +G+
Sbjct 1064 NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL----SLKGW-- 1117
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM 380
+ R + + + +G L + V + + ++
Sbjct 1118 ------VEVRDVIIHRVGPIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGT 1165
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL 440
+ + ++ L + L + PPRP+ F + H +F L
Sbjct 1166 ALLT------VDQRRWEDLKSRLKIAQPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIAL 1218
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ LA V + V ++ V L ++ VF ++LE+ +K+ A+ G+
Sbjct 1219 LVLAQSVLLSVKWDVEDPVTVP------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
Query 501 SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
N +D L+T + +V + A+ +IVFRF I
Sbjct 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA----------------CVIVFRFFSICG 1316
Query 561 SMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
+ ++ TV+ + + ++ +A G+ LF V N
Sbjct 1317 KHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENIN--------- 1367
Query 621 APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-DA--------------YRRY 665
NF A+ L+ ++ +W + D +
Sbjct 1368 -----------RHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATD 1416
Query 666 SGPW--SKIYFVLWWLVSSVIWVNLFLALILENFL 698
G + + +YF ++++ + I +NL +A+I+ENF
Sbjct 1417 CGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
Score = 153 bits (386), Expect = 7e-37, Method: Composition-based stats.
Identities = 67/376 (18%), Positives = 140/376 (37%), Gaps = 46/376 (12%)
Query 357 VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF----QKLFNELDRSVVKEHP 412
+ + ++++Q+ + + K+ + E+ F + F R VV+
Sbjct 799 QREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARF 858
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNL-----IALANLVSICVFLVLDADVLPAERDDF 467
P + + H +D LG + + + + C+ ++ ++
Sbjct 859 N-ASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESPFRRVMHA-P 916
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 917 TLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFL------- 969
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
W P+ V S ++L +L R LRI + M V + + + +L+
Sbjct 970 -CWMPQNVPAESGA---QLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLL 1025
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA--------------------PCGSFE 627
+ VFA G+ LF G + + + + + F
Sbjct 1026 TLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENFLH 699
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANFNE 1161
Score = 131 bits (328), Expect = 9e-30, Method: Composition-based stats.
Identities = 96/684 (14%), Positives = 216/684 (32%), Gaps = 109/684 (16%)
Query 91 FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG----YL 146
++ L S + + + P +T +++ L + ++ A++ K +
Sbjct 37 WVHSLLRICAIISVIPVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIV 96
Query 147 FGWAHFQKNLWLLGYLVVLV---VSLVDWTVSLSLVCHEP-----LRIRRLL---RPFFL 195
G + + K+ W + ++ VSLV ++ + + LRI R L R F +
Sbjct 97 KGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRI 156
Query 196 LQNSSMMK-KTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ + + ++ S ++ SV + L L L+ + G+ +F + +
Sbjct 157 YFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGN 216
Query 255 ---------FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+ L D+ S+ F + +
Sbjct 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGF-------NEIGTS 269
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
+ T S G++ + ++ + + V V
Sbjct 270 IFTVYEASSQEGWVF-LMYRAIDSF-----PRWRSYFYFITLIFFLAWLV-------KNV 316
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVK---EHPPRPEYQSPFL 422
V +++ + + + ++ ++F+E + +P+ ++P
Sbjct 317 FIAVIIETFAEIRVQFQQMWGTRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPAC 376
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCVFIVYY 480
Q + F ++V++ V + + F V +
Sbjct 377 --LQKMMRSSVFHMFI-----LSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF 429
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
LE LLK++ LG GY+S + F+ LL + +P
Sbjct 430 DLEALLKIWCLGFTGYISSSLHKFELLLVI----------GTTLHVYPDLYHSQFTY--- 476
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
V R +R+I + + G + + + + V + I + +
Sbjct 477 ---------FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F + F F A ++++ ++ W +D
Sbjct 528 FC--------------------------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMD 561
Query 661 AYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
G P IYF+L+ L +++I ++LF+A+IL+N D + Q A
Sbjct 562 QTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANA 621
Query 717 TYQMTVELLFRDILEEPGEDELTE 740
+ + L R + P ++ +
Sbjct 622 DTKEKLPLRLRIFEKFPNRPQMVK 645
>sp|Q8BXR5|NALCN_MOUSE Sodium leak channel NALCN OS=Mus musculus
OX=10090 GN=Nalcn PE=1 SV=2
Length=1738
Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats.
Identities = 108/635 (17%), Positives = 222/635 (35%), Gaps = 95/635 (15%)
Query 92 LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-EVLCLLVFAADLSVK----GYL 146
L+ +L ++ ++ S + + + T + E + ++ + +L++K G
Sbjct 884 LVTYLDWVMITVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLF 943
Query 147 FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP----LRIRRLLRPFFLLQNSSMM 202
F ++ + + + +VSL+ V E L + R LRP + + M
Sbjct 944 FTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQM 1003
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGK-QDDGQDRERLTYFQNLPES 261
+K ++ + E+ V +LL + +F FG+ LFAG + + + R +
Sbjct 1004 RKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI 1063
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
S+ L P P + R +A F +G+ L +G+
Sbjct 1064 NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL----SLKGW-- 1117
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM 380
+ R + + + +G L + V + + ++
Sbjct 1118 ------VEVRDVIIHRVGPIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGT 1165
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL 440
+ + ++ L + L + PPRP+ F + H +F L
Sbjct 1166 ALLT------VDQRRWEDLKSRLKIAQPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIAL 1218
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ LA V + V +D V L ++ VF ++LE+ +K+ A+ G+
Sbjct 1219 LVLAQSVLLSVKWDVDDPVTVP------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
Query 501 SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
N +D L+T + +V + A+ +IVFRF I
Sbjct 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA----------------CVIVFRFFSICG 1316
Query 561 SMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
+ ++ TV+ + + ++ +A G+ LF V N
Sbjct 1317 KHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENIN--------- 1367
Query 621 APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-DA--------------YRRY 665
NF A+ L+ ++ +W + D +
Sbjct 1368 -----------RHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATD 1416
Query 666 SGPW--SKIYFVLWWLVSSVIWVNLFLALILENFL 698
G + + +YF ++++ + I +NL +A+I+ENF
Sbjct 1417 CGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
Score = 153 bits (387), Expect = 6e-37, Method: Composition-based stats.
Identities = 67/376 (18%), Positives = 140/376 (37%), Gaps = 46/376 (12%)
Query 357 VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF----QKLFNELDRSVVKEHP 412
+ + ++++Q+ + + K+ + E+ F + F R VV+
Sbjct 799 QREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARF 858
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNL-----IALANLVSICVFLVLDADVLPAERDDF 467
P + + H +D LG + + + + C+ ++ ++
Sbjct 859 N-ASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMFESPFRRVMHA-P 916
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 917 TLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFL------- 969
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
W P+ V S ++L +L R LRI + M V + + + +L+
Sbjct 970 -CWMPQNVPAESGA---QLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLL 1025
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA--------------------PCGSFE 627
+ VFA G+ LF G + + + + + F
Sbjct 1026 TLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENFLH 699
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANFNE 1161
Score = 130 bits (327), Expect = 1e-29, Method: Composition-based stats.
Identities = 96/684 (14%), Positives = 217/684 (32%), Gaps = 109/684 (16%)
Query 91 FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG----YL 146
++ L S ++ + + P +T +++ L + ++ A++ K +
Sbjct 37 WVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIV 96
Query 147 FGWAHFQKNLWLLGYLVVLV---VSLVDWTVSLSLVCHEP-----LRIRRLL---RPFFL 195
G + + K+ W + ++ VSLV ++ + + LRI R L R F +
Sbjct 97 KGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRI 156
Query 196 LQNSSMMK-KTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ + + ++ S ++ SV + L L L+ + G+ +F + +
Sbjct 157 YFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGN 216
Query 255 ---------FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+ L D+ S+ F + +
Sbjct 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGF-------NEIGTS 269
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
+ T S G++ + ++ + + V V
Sbjct 270 IFTVYEASSQEGWVF-LMYRAIDSF-----PRWRSYFYFITLIFFLAWLV-------KNV 316
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVK---EHPPRPEYQSPFL 422
V +++ + + + ++ ++F+E + +P+ ++P
Sbjct 317 FIAVIIETFAEIRVQFQQMWGTRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPAC 376
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCVFIVYY 480
Q + F ++V++ V + + F V +
Sbjct 377 --LQKMMRSSVFHMFI-----LSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF 429
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
LE LLK++ LG GY+S + F+ LL + +P
Sbjct 430 DLEALLKIWCLGFTGYISSSLHKFELLLVI----------GTTLHVYPDLYHSQFTY--- 476
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
V R +R+I + + G + + + + V + I + +
Sbjct 477 ---------FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F + F F A ++++ ++ W +D
Sbjct 528 FC--------------------------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMD 561
Query 661 AYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
G P IYF+L+ L +++I ++LF+A+IL+N D + Q A
Sbjct 562 QTLNAVGHMWAPLVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANA 621
Query 717 TYQMTVELLFRDILEEPGEDELTE 740
+ + L R + P ++ +
Sbjct 622 DTKEKLPLRLRIFEKFPNRPQMVK 645
>sp|Q8IZF0|NALCN_HUMAN Sodium leak channel NALCN OS=Homo sapiens
OX=9606 GN=NALCN PE=1 SV=1
Length=1738
Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats.
Identities = 107/635 (17%), Positives = 222/635 (35%), Gaps = 95/635 (15%)
Query 92 LILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESV-EVLCLLVFAADLSVK----GYL 146
L+ +L ++ ++ S + + + T + E + ++ + +L++K G
Sbjct 884 LVTYLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLF 943
Query 147 FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP----LRIRRLLRPFFLLQNSSMM 202
F ++ + + + +VSL+ V E L + R LRP + + M
Sbjct 944 FTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQM 1003
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG-KQDDGQDRERLTYFQNLPES 261
+K ++ + E+ V +LL + +F FG+ LFAG + + + R +
Sbjct 1004 RKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI 1063
Query 262 LTSLLVLLTTANNPDVMIPAYSKNRAYAIF-FIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
S+ L P P + R +A F +G+ L +G+
Sbjct 1064 NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVL----SLKGW-- 1117
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMM 380
+ R + + + +G L + V + + ++
Sbjct 1118 ------VEVRDVIIHRVGPIHGIYIHVFVFLGCMIG------LTLFVGVVIANFNENKGT 1165
Query 381 EKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNL 440
+ + ++ L + L + PPRP+ F + H +F L
Sbjct 1166 ALLT------VDQRRWEDLKSRLKIAQPLHLPPRPDN-DGFRAKMYDITQHPFFKRTIAL 1218
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ LA V + V ++ V L ++ VF ++LE+ +K+ A+ G+
Sbjct 1219 LVLAQSVLLSVKWDVEDPVTVP------LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSR 1272
Query 501 SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIP 560
N +D L+T + +V + A+ +IVFRF I
Sbjct 1273 RNRYDLLVTSLGVVWVVLHFALLNAYTYMMGA----------------CVIVFRFFSICG 1316
Query 561 SMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGS 620
+ ++ TV+ + + ++ +A G+ LF V N
Sbjct 1317 KHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENIN--------- 1367
Query 621 APCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-DA--------------YRRY 665
NF A+ L+ ++ +W + D +
Sbjct 1368 -----------RHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATD 1416
Query 666 SGPW--SKIYFVLWWLVSSVIWVNLFLALILENFL 698
G + + +YF ++++ + I +NL +A+I+ENF
Sbjct 1417 CGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1451
Score = 153 bits (387), Expect = 5e-37, Method: Composition-based stats.
Identities = 67/376 (18%), Positives = 140/376 (37%), Gaps = 46/376 (12%)
Query 357 VKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF----QKLFNELDRSVVKEHP 412
+ + ++++Q+ + + K+ + E+ F + F R VV+
Sbjct 799 QREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVVVRARF 858
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNL-----IALANLVSICVFLVLDADVLPAERDDF 467
P + + H +D LG + + + + C+ ++ ++
Sbjct 859 N-ASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSCISMMFESPFRRVMHA-P 916
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
L I VF+++ +E+ LK+ A GL + F G++ + + ++ + L
Sbjct 917 TLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFL------- 969
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
W P+ V S ++L +L R LRI + M V + + + +L+
Sbjct 970 -CWMPQNVPAESGA---QLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLL 1025
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSA--------------------PCGSFE 627
+ VFA G+ LF G + + + + + F
Sbjct 1026 TLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFW 1085
Query 628 QLEYWAN----NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSV 683
WAN NFD+ A++ L+ ++ + W D GP IY ++ + +
Sbjct 1086 VPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCM 1145
Query 684 IWVNLFLALILENFLH 699
I + LF+ +++ NF
Sbjct 1146 IGLTLFVGVVIANFNE 1161
Score = 130 bits (327), Expect = 1e-29, Method: Composition-based stats.
Identities = 95/684 (14%), Positives = 217/684 (32%), Gaps = 109/684 (16%)
Query 91 FLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG----YL 146
++ L S ++ + + P +T +++ L + ++ A++ K +
Sbjct 37 WVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIV 96
Query 147 FGWAHFQKNLWLLGYLVVLV---VSLVDWTVSLSLVCHEP-----LRIRRLL---RPFFL 195
G + + K+ W + ++ VSLV ++ + + LRI R L R F +
Sbjct 97 KGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRI 156
Query 196 LQNSSMMK-KTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ + + ++ S ++ SV + L L L+ + G+ +F + +
Sbjct 157 YFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGN 216
Query 255 ---------FQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMN 305
+ L D+ S+ F + +
Sbjct 217 VTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGF-------NEIGTS 269
Query 306 LLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
+ T + G++ + ++ + + V V
Sbjct 270 IFTVYEAASQEGWVF-LMYRAIDSF-----PRWRSYFYFITLIFFLAWLV-------KNV 316
Query 366 LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVK---EHPPRPEYQSPFL 422
V +++ + + + ++ ++F+E + +P+ ++P
Sbjct 317 FIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPAC 376
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI--LGILNCVFIVYY 480
Q + F ++V++ V + + F V +
Sbjct 377 --LQKMMRSSVFHMFI-----LSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLF 429
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
LE LLK++ LG GY+S + F+ LL + +P
Sbjct 430 DLEALLKIWCLGFTGYISSSLHKFELLLVI----------GTTLHVYPDLYHSQFTY--- 476
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
V R +R+I + + G + + + + V + I + +
Sbjct 477 ---------FQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQM 527
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F + F F A ++++ ++ W +D
Sbjct 528 FC--------------------------FVEELDRFTTFPRAFMSMFQILTQEGWVDVMD 561
Query 661 AYRRYSG----PWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEA 716
G P IYF+L+ L +++I ++LF+A+IL+N D + Q A
Sbjct 562 QTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSEANA 621
Query 717 TYQMTVELLFRDILEEPGEDELTE 740
+ + L R + P ++ +
Sbjct 622 DTKEKLPLRLRIFEKFPNRPQMVK 645
>sp|Q91ZR5|CTSR1_MOUSE Cation channel sperm-associated protein
1 OS=Mus musculus OX=10090 GN=Catsper1 PE=1 SV=1
Length=686
Score = 169 bits (427), Expect = 8e-43, Method: Composition-based stats.
Identities = 56/279 (20%), Positives = 117/279 (42%), Gaps = 38/279 (14%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
Q L F+ ++ N V LV R ++ +L+ +F+ Y
Sbjct 340 LQQMILSLTQSLGFETFIFIVVCLNT----VILVAQTFTELEIRGEWYFMVLDSIFLSIY 395
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
+LE +LK+ ALGL Y P N D + +V+ VL+ L + L + + + +L +
Sbjct 396 VLEAVLKLIALGLE-YFYDPWNNLDFFI-MVMAVLDFVLLQINSLSYSFYNHSLFRILKV 453
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ + + L R LR + + + VA T+ G + ++ A ++ ++F+++ L
Sbjct 454 F---KSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRAL 510
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
F+ + F + L TL+ ++ +++W +
Sbjct 511 FQ---------------------------DSDPKRFQNIFTTLFTLFTMLTLDDWS-LIY 542
Query 661 AYRRYSGPWSKIYF-VLWWLVSSVIWVNLFLALILENFL 698
R G W I +++ ++ I++NL +A++++NF
Sbjct 543 IDNRAQGAWYIIPILMIYIVIQYFIFLNLVIAVLVDNFQ 581
Score = 109 bits (272), Expect = 2e-23, Method: Composition-based stats.
Identities = 49/311 (16%), Positives = 112/311 (36%), Gaps = 49/311 (16%)
Query 38 AAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMW--LYRRYYSNVCQRTLSFT------ 89
A +R L ++ ED +Q R R + +++ + + L
Sbjct 288 AQSRESLRESASLSEGEDHVQKRKKAQRAHKKAHTGNIFQLLWEKISHLLLGLQQMILSL 347
Query 90 ---------IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
IF+++ L + + + ++R ++ + L ++ +
Sbjct 348 TQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMV--------LDSIFLSIYVLEA 399
Query 141 SVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS--------------LVCHEPLRI 186
+K G +F L + ++++ L + ++ L + +R
Sbjct 400 VLKLIALGLEYFYDPWNNLDFFIMVMAVLDFVLLQINSLSYSFYNHSLFRILKVFKSMRA 459
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R +R L + + + + SLP + ++ L+ L LF++ LF
Sbjct 460 LRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLFSVVLRALF-------- 511
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIF-FIVFTVIGSLFLMN 305
FQN+ +L +L +LT + + I ++ Y I +++ VI +N
Sbjct 512 -QDSDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQGAWYIIPILMIYIVIQYFIFLN 570
Query 306 LLTAIIYSQFR 316
L+ A++ F+
Sbjct 571 LVIAVLVDNFQ 581
>sp|O14234|CCH1_SCHPO Calcium-channel protein cch1 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=cch1
PE=3 SV=1
Length=1854
Score = 161 bits (407), Expect = 2e-39, Method: Composition-based stats.
Identities = 104/689 (15%), Positives = 209/689 (30%), Gaps = 113/689 (16%)
Query 77 YYSNVCQRTLS----------------FTIFLILFLAFIETPSSLTSTADVRYRAAPWEP 120
CQR + + + + A I T + A Y
Sbjct 914 RIRRFCQRLVMPGVNERYGGVEPYQWVYRVIQVFIYACILTAVIIECIATPIYERDHLLN 973
Query 121 PCGLTESV--EVLCLLVFAADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLVDWTV 174
V EV +F + ++K G+ + ++ W VLV ++
Sbjct 974 DKQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYA 1033
Query 175 SL--SLVCHEPLRIRRLLRPFFLLQNSSMMKKTL-KCIRWSLPEMASVGLLLAIHLCLFT 231
L + R + LR L+ + ++ + ++ S ++ A L F
Sbjct 1034 VLTSHALLSRAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFA 1093
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIF 291
++ +F G N+ + +L +T NN +V P N F
Sbjct 1094 LWAKNVFGGLLYSC--------NDDNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDF 1145
Query 292 FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF 351
F LL + G++ +++ + + ++ G F
Sbjct 1146 --------DRFPHALLALFEIASIEGWV-DIMRSVMDITGFNNQPQ---TNASSGNAMFF 1193
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
V +L + + + + ++ E + +
Sbjct 1194 VLFNLVSMIYILTLFIAIIISNYAERTGSA---------FFTAEQRAWLELRRKIKSMRP 1244
Query 412 PPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGI 471
RP + L+ + F +V + L + A +
Sbjct 1245 SKRPAIRPLGLRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTIFYPCPIA-----YTYV 1299
Query 472 LNCVFIVY---YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
N +F++ Y + + +KV+ L + N+FD ++T+ L I+ LA +
Sbjct 1300 RNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSL 1359
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
+ +L + IP ++ TV+ + ++ + +V
Sbjct 1360 TLLQTTLLVLVTVHL---------------IPKFDNFDQLSKTVVASLPSIFSLIATWIV 1404
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+Y FAI +F + L G NF ALV L+
Sbjct 1405 LYITFAIAFNQIFGLTKLGLNGGP--------------------NKNFRSIRNALVLLFT 1444
Query 649 LMVVNNWQVFL--------------DAYRRYSG--PWSKIYFVLWWLVSSVIWVNLFLAL 692
+ W + D Y G PW+ F+ W ++S I+VN+F+ +
Sbjct 1445 MTFGEGWNDVMHDYTISYPNCVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITV 1504
Query 693 ILENFLHKWDPRSHLQPLAGTPEATYQMT 721
+ +NF + S L ++ +
Sbjct 1505 VFDNFSYIHTKSSSFTNLQRNDFRQFKDS 1533
Score = 99.4 bits (246), Expect = 6e-20, Method: Composition-based stats.
Identities = 82/666 (12%), Positives = 194/666 (29%), Gaps = 146/666 (22%)
Query 83 QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSV 142
++ + ++ I I + L + + ++ +++ ++ +
Sbjct 179 RQIYNHPLYNIFIFVVIVLHAVLLMIRSDD-----PHDKSQTIDYLIIVIGILYTLEMLL 233
Query 143 KGYLFGW----------------------AHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC 180
K YLFG+ + ++ W V +V +
Sbjct 234 KIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWISVIGKKQQGI 293
Query 181 HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
+ LR LL + + LK ++ S + V A + + G+ F
Sbjct 294 FRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKA 353
Query 241 GKQDDG---------------------QDRERLTYFQN--LPESLTSLLVLLTTANNPDV 277
++ + Y P ++ + + V
Sbjct 354 SLNRQCVWLGDYGDQYLPTGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRV 413
Query 278 MIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAA 337
+ YS ++ FF +I + + F + +
Sbjct 414 VENPYSNTVSFDNFFNSLELI--------FVIMSSNGFTDIMYDIMDA------------ 453
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ + L ++ V + F
Sbjct 454 --------EYFVSCLLFIISAYFLTLWLMSLVIA-------------------VVTSSFI 486
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA 457
L + ++ + ++ + F Y +++ +A V++C
Sbjct 487 DLQHSGKNQKEQKSVDKHLIRNKLCEKYLF-----YSNFIWISFIVAQFVTLCTQTY--- 538
Query 458 DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEI 517
D + + +++ F++ E++L+ FA + L+ +VL VL +
Sbjct 539 DQTSSTANRYLIFYACVDFLL--AAEVILRFFAYLPDY--RLFFRRYTNLVDIVLAVLNL 594
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
TL LP P G LS++ + R R I + +A + +
Sbjct 595 VTL----LPSIRKNPVAFGWLSIFAI---------ARIYRCILLIPYTRKIAKLLFSNFK 641
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
+ LV+V ++ ++ + LF+ + + F
Sbjct 642 QLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAIS-------------------FA 682
Query 638 DFAAALVTLWNLMVVNNWQVFLDAYRRYSGP-----WSKIYFVLWWLVSSVIWVNLFLAL 692
+ + ++ ++ NW + A + +F LW+L S+ + +++F+A+
Sbjct 683 TTYESFLYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAV 742
Query 693 ILENFL 698
I NF
Sbjct 743 IQVNFA 748
Score = 84.4 bits (207), Expect = 2e-15, Method: Composition-based stats.
Identities = 47/381 (12%), Positives = 110/381 (29%), Gaps = 86/381 (23%)
Query 396 FQKLFNELDRSVVKEHPPRPEYQS-PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
F +++ + R V ++ PF + ++ H ++ ++ + + V + +
Sbjct 148 FSEIYAAVLRVVGPPRANETPGRNLPFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIR-- 205
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG------------------- 495
+ L V + Y LEMLLK++ G
Sbjct 206 ----SDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPR 261
Query 496 ---YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
YL + N D + V L + I + R+ +M+
Sbjct 262 TMSYLRHSWNRVDFVAIVALWISVI-------------------GKKQQGIFRLFSMIAC 302
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR---------- 602
R R++ + + ++ + + AI+G+ F+
Sbjct 303 LRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWL 362
Query 603 ----------GVI------------------VALPGNSSLAPANGSAPCGSFEQLEYWAN 634
G N + C E
Sbjct 363 GDYGDQYLPTGQFCGGHWENGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTV 422
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+FD+F +L ++ +M N + + S + F++ ++ ++L +A++
Sbjct 423 SFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFLTLWLMSLVIAVVT 482
Query 695 ENFLHKWDPRSHLQPLAGTPE 715
+F+ + + +
Sbjct 483 SSFIDLQHSGKNQKEQKSVDK 503
Score = 67.1 bits (162), Expect = 6e-10, Method: Composition-based stats.
Identities = 58/354 (16%), Positives = 137/354 (39%), Gaps = 27/354 (8%)
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ +C++ L ++ F ++++FI T ++ V+ + AA
Sbjct 508 NKLCEKYLFYSNF--IWISFIVAQFVTLCTQTYDQTSSTANRYLIFYACVD----FLLAA 561
Query 139 DLSVKGYLF--GWAHFQKNLWLLGYLVVLVVSLVDWTVSL--SLVCHEPLRIRRLLRPFF 194
++ ++ + + + F + L +V+ V++LV S+ + V L I + R +
Sbjct 562 EVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSIFAIARIYR 621
Query 195 LLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTY 254
+ +K K + + ++ ++ L L I L + ++ + LF D D + +++
Sbjct 622 CILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISF 681
Query 255 FQNLPESLTSLLVLLTTANNPDVMIPAYSK----NRAY--AIFFIVFTVIGSLFLMNLLT 308
ES + +LT+ N DVM ++ + ++ FF ++ + + ++++
Sbjct 682 ATTY-ESFLYMYQILTSENWTDVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFI 740
Query 309 AIIYSQFRGYLMKS------LQTSLFRRRLGT-RAAFEVLSSMVGEGGAFPQAVGVKPQN 361
A+I F + + R +A+ + + + G + V
Sbjct 741 AVIQVNFAPSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYE 800
Query 362 LL---QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP 412
L +++ ++ K S LS KL N R V+++ P
Sbjct 801 WLYEDNIIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDP 854
>sp|A2ARP9|CTSR2_MOUSE Cation channel sperm-associated protein
2 OS=Mus musculus OX=10090 GN=Catsper2 PE=1 SV=2
Length=588
Score = 151 bits (380), Expect = 3e-37, Method: Composition-based stats.
Identities = 63/304 (21%), Positives = 123/304 (40%), Gaps = 40/304 (13%)
Query 420 PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD-DFILGILNCVFIV 478
P A ++ F + N + V + L A L + + ++
Sbjct 94 PLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILL 153
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+++E+LL A + NVFD +T++ L+ E+ L G+
Sbjct 154 SFIVEILLMWLA-SFSLFWKDAWNVFDFFVTLLSLLPELVVLL--------------GVP 198
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+ ++L + V R L++ + + V+ ++ +++M +L++ +Y+FA+ G+
Sbjct 199 AHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGV 258
Query 599 NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF 658
F + E LEY F D +LVT++ L +++W
Sbjct 259 YFF-----------------REYSRSTIEGLEYNMF-FSDLLNSLVTVFILFTLDHWYAV 300
Query 659 LDAY---RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPE 715
L S +S IY +LW L+ S+I+ N+ +A+++ NF + RS L E
Sbjct 301 LQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQ---NIRSELSEEMSHLE 357
Query 716 ATYQ 719
Y+
Sbjct 358 VQYK 361
Score = 124 bits (310), Expect = 3e-28, Method: Composition-based stats.
Identities = 52/245 (21%), Positives = 101/245 (41%), Gaps = 12/245 (5%)
Query 84 RTLSFTIFL--ILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
L ++F I+ L F+ T + + P E + LL F ++
Sbjct 101 WVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEIL 160
Query 142 VKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP-----LRIRRLLRPFFLL 196
+ ++ F K+ W + V ++SL+ V L V LR+ R+LR L
Sbjct 161 LMWLAS-FSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLF 219
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+K L + +L M + +LL I +F + G+ F + + E +F
Sbjct 220 ARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFS 279
Query 257 NLPESLTSLLVLLTTANN----PDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
+L SL ++ +L T + D+ S +I+ I++ ++GS+ N++ A++
Sbjct 280 DLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMV 339
Query 313 SQFRG 317
+ F+
Sbjct 340 TNFQN 344
>sp|Q6AXP6|CTSR2_RAT Cation channel sperm-associated protein 2
OS=Rattus norvegicus OX=10116 GN=Catsper2 PE=2 SV=1
Length=584
Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats.
Identities = 67/335 (20%), Positives = 137/335 (41%), Gaps = 42/335 (13%)
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL-DADVLPAERDDFILGIL 472
R + P A ++ F + N + V + L ++ L +
Sbjct 88 RCGGRPPLSLWAGWVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVT 147
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
+ ++ +++E+LL A + +VFD ++T++ L+ E L
Sbjct 148 DWFILLSFIVEILLMWLA-SFFLFWKNAWSVFDFVVTMLSLLPEFVVL------------ 194
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
+G+ + ++L + V R L++ + V+ ++ +++M +L++ +YV
Sbjct 195 --IGVSADSVWLQLLRVSRVLRSLKLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYV 252
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
FA+ G+ F+ + E LEY F D +LVT++ L +
Sbjct 253 FAVAGVYFFK-----------------EYSRSTIENLEYNMF-FSDLLNSLVTVFILFTL 294
Query 653 NNWQVFLD---AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
++W L S +S IY +LW L+ S+I+ N+ +A+++ NF + R+ L
Sbjct 295 DHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQ---NIRNELHE 351
Query 710 LAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
E Y+ ++ R I++ + E SQ
Sbjct 352 EMTHLEVQYK--ADIFKRRIIQRRQQSESLRGTSQ 384
Score = 129 bits (323), Expect = 7e-30, Method: Composition-based stats.
Identities = 66/371 (18%), Positives = 132/371 (36%), Gaps = 22/371 (6%)
Query 84 RTLSFTIFLILF--LAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLS 141
L +IF L F+ T + + P E + LL F ++
Sbjct 101 WVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEIL 160
Query 142 VKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP-----LRIRRLLRPFFLL 196
+ + F KN W + VV ++SL+ V L V + LR+ R+LR L
Sbjct 161 LMWLASFF-LFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKLF 219
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
+K L + +L M + +LL I +F + G+ F + ++ E +F
Sbjct 220 ARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTIENLEYNMFFS 279
Query 257 NLPESLTSLLVLLTTANN----PDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
+L SL ++ +L T + DV + +I+ I++ ++GS+ N++ A++
Sbjct 280 DLLNSLVTVFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMV 339
Query 313 SQFRGYL---------MKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ F+ ++ + +R + + S G + + +
Sbjct 340 TNFQNIRNELHEEMTHLEVQYKADIFKRRIIQRRQQSESLRGTSQGKVSEDITETSEAT- 398
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
+ +S +++ EK S +E + E D E
Sbjct 399 DEEKSEAEESEEEKSEEEKSDVEKSDEEKNDEEKSDEEENDEEKSDVEKSDEEKNDEEKG 458
Query 424 SAQFLFGHYYF 434
+ ++ F
Sbjct 459 YTEKVYSGRTF 469
>sp|Q7RTX7|CTSR4_HUMAN Cation channel sperm-associated protein
4 OS=Homo sapiens OX=9606 GN=CATSPER4 PE=1 SV=1
Length=472
Score = 134 bits (337), Expect = 4e-32, Method: Composition-based stats.
Identities = 44/215 (20%), Positives = 102/215 (47%), Gaps = 22/215 (10%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLV-DWTVSLSLVCH- 181
L +++ + L + ++ + G+L G+ F K+ W + +++ + L+ + +++
Sbjct 124 LFSTIDDIVLTILLCEVLL-GWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSIN 182
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
LR RL+ + + + ++ I S+P+MA++ +L+ + +F++FG+ LF
Sbjct 183 YTLRALRLVHVCMAV---EPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAF 239
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY------AIFFIVF 295
+FQN+ +L +L + +T D+ ++ R Y AI+F +F
Sbjct 240 VP---------KHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIF 290
Query 296 TVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
IG+ +NL ++ + +MK+ + +R
Sbjct 291 ITIGAFIGINLFVIVVTTNLE-QMMKAGEQGQQQR 324
Score = 107 bits (267), Expect = 3e-23, Method: Composition-based stats.
Identities = 42/291 (14%), Positives = 101/291 (35%), Gaps = 57/291 (20%)
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ L H F L L+ + N ++I L + ++ + ++ + + L E
Sbjct 84 YIKQLLRHPAFQLLLALLLVINAITI----ALRTNSYLDQKHYELFSTIDDIVLTILLCE 139
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
+LL G + N+ + ++ +LL + ++ ++
Sbjct 140 VLLGWLN-GFWIFWKDGWNILNFIIVFILL--------------------LRFFINEINI 178
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+ L R + + +++ +A + +L V +M +++ VF++ G+ LF
Sbjct 179 PSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFG- 237
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
+ +F + AL TL+ + + W ++
Sbjct 238 --------------------------AFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQ 271
Query 664 RYSGPWSK-----IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQP 709
++ IYF ++ + + I +NLF+ ++ N Q
Sbjct 272 TEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQ 322
>sp|Q8BVN3|CTSR4_MOUSE Cation channel sperm-associated protein
4 OS=Mus musculus OX=10090 GN=Catsper4 PE=1 SV=1
Length=442
Score = 132 bits (333), Expect = 7e-32, Method: Composition-based stats.
Identities = 45/205 (22%), Positives = 94/205 (46%), Gaps = 21/205 (10%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYL-VVLVVSLVDWTVSLSLVCH- 181
L +++ + L + ++ + G+L G+ F K+ W + +V ++ + + L +V
Sbjct 100 LFSTIDDIVLTILICEVLL-GWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAIT 158
Query 182 EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGG 241
PLR+ RL+ + + + +K I S+P++A+V L+ + +F++FG+ LF
Sbjct 159 YPLRVLRLVHVCMAV---EPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAF 215
Query 242 KQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY------AIFFIVF 295
+FQN+ +L +L + +T D+ R Y AI+F VF
Sbjct 216 VP---------KHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVF 266
Query 296 TVIGSLFLMNLLTAIIYSQFRGYLM 320
+G+ +NL ++ + +
Sbjct 267 ITLGAFIGLNLFVVVVTTNLEQMMK 291
Score = 100 bits (248), Expect = 5e-21, Method: Composition-based stats.
Identities = 43/302 (14%), Positives = 97/302 (32%), Gaps = 56/302 (19%)
Query 448 SICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
S + + L + ++ + ++ + + + E+LL G + N+ +
Sbjct 80 SNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLN-GFWIFWKDGWNILNFA 138
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+ +L M + DM + L V R + + +++ +A
Sbjct 139 IVFILF--------------------MGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLAR 178
Query 568 VASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
+ +L + ++ +++ VF++ G+ LF
Sbjct 179 IIKVILQSMPDLANVMALILFFMLVFSVFGVTLFG------------------------- 213
Query 628 QLEYWANNFDDFAAALVTLWNLMVVNNWQVF-----LDAYRRYSGPWSKIYFVLWWLVSS 682
+ +F + AL TL+ + + W +D IYF ++ + +
Sbjct 214 --AFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGA 271
Query 683 VIWVNLFLALILENFL---HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELT 739
I +NLF+ ++ N + HL E T EL E +
Sbjct 272 FIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTV 331
Query 740 ER 741
+
Sbjct 332 PK 333
>sp|Q8NEC5|CTSR1_HUMAN Cation channel sperm-associated protein
1 OS=Homo sapiens OX=9606 GN=CATSPER1 PE=1 SV=3
Length=780
Score = 134 bits (338), Expect = 3e-31, Method: Composition-based stats.
Identities = 53/324 (16%), Positives = 114/324 (35%), Gaps = 43/324 (13%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYY 480
F + + L F+ + N V + + ++ R ++ L+ +F Y
Sbjct 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEI----RGEWYFMALDSIFFCIY 491
Query 481 LLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSL 540
++E LLK+ ALGL Y N D + + ++ + + L +
Sbjct 492 VVEALLKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQ------SLFRI 544
Query 541 WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
+ + L L R LR + + + V T+ + ++ A ++ ++F+ + L
Sbjct 545 LKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRAL 604
Query 601 FRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLD 660
FR F + + TL+ L+ +++W +
Sbjct 605 FRK---------------------------SDPKRFQNIFTTIFTLFTLLTLDDWSLIYM 637
Query 661 AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQM 720
R + V++ ++ I++NL + +++++F + L +
Sbjct 638 DSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTAL-----FKGLEKAKQERAAR 692
Query 721 TVELLFRDILEEPGEDELTERLSQ 744
E L D L E E E S+
Sbjct 693 IQEKLLEDSLTELRAAEPKEVASE 716
Score = 104 bits (259), Expect = 9e-22, Method: Composition-based stats.
Identities = 54/342 (16%), Positives = 131/342 (38%), Gaps = 36/342 (11%)
Query 74 YRRYYSNVCQRT-LSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
+R N+ Q IF ++ L + + + ++R +++ +
Sbjct 436 FREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFM--------ALDSIF 487
Query 133 LLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS-------------LV 179
++ + +K G + + W ++ ++++D+ + + L
Sbjct 488 FCIYVVEALLKIIALGL-SYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILK 546
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
+ LR R +R L + +++ + SLP +A++ +L+ L LF+ LF
Sbjct 547 VFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALF- 605
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY-AIFFIVFTVI 298
+ FQN+ ++ +L LLT + + + + ++ Y +++ +I
Sbjct 606 --------RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIII 657
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVK 358
+NL+ ++ F+ L K L+ + R + +L + E A
Sbjct 658 QYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEK--LLEDSLTELRAAEPKEVAS 715
Query 359 PQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLF 400
+L+ L + + + + E + Y ++ S E+ Q+ F
Sbjct 716 EGTMLKRLIEKKF-GTMTEKQQELLFHYLQLVASVEQEQQKF 756
>sp|P50077|CCH1_YEAST Calcium-channel protein CCH1 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CCH1
PE=1 SV=1
Length=2039
Score = 134 bits (338), Expect = 6e-31, Method: Composition-based stats.
Identities = 107/716 (15%), Positives = 214/716 (30%), Gaps = 107/716 (15%)
Query 61 SINHRVDASSMWL------YRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYR 114
S R D S + +R Y + +R + IF + + I +T YR
Sbjct 1176 STGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVFIFALATILLIVCSCYVT----PLYR 1231
Query 115 AAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW----AHFQKNLWLLGYLVVLVVSLV 170
+ +++ + F+ + VK G+ + +N W VL+ +
Sbjct 1232 MHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWI 1291
Query 171 DWTVSLSLVC-----HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
+ L + L R LR + + + + L ++ GL+
Sbjct 1292 NLIAYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLV--MFDGLNKIFEAGLISLS 1349
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
L FT++G+ +F G E S+ D+M P +
Sbjct 1350 LLFPFTVWGLSIFKGRLGTCNDGSLGRA--DCYNEYSNSVFQW-------DIMSPRVYQQ 1400
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
S F G++ L+ + +GT A +
Sbjct 1401 PYLH-----LDSFASAFSSLYQII----SLEGWV-DLLENMMNSSGIGTPA---TVMGSA 1447
Query 346 GEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNE--L 403
G + +L + +++ + R+ GS + EE L ++ L
Sbjct 1448 GNALFLVLFNFLSMVFILNLFVSFIVNN--------QARTTGSAYFTIEEKAWLESQKLL 1499
Query 404 DRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAE 463
++ K P E Q F Y L + L + ++L P
Sbjct 1500 SQAKPKAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYL---HIIMLLSRSYNPGN 1556
Query 464 RDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY 523
+ G+ +L++ L + G R Y N + ++ ++ V
Sbjct 1557 LIGY-QGVYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVP 1615
Query 524 RLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
+ + LL + FL IIP + + T + + + +
Sbjct 1616 ASHYWFHNIKGFFLLVI--------------FLFIIPQNDTLTELLETAMASLPPILSLT 1661
Query 584 GILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAAL 643
V++ V+AI +F + ++ NF ++
Sbjct 1662 YTWGVLFLVYAIALNQIFGLTRLGSNTTDNI--------------------NFRTVIKSM 1701
Query 644 VTLWNLMVVNNWQVFL--------------DAYRRYSGPWSKIYF--VLWWLVSSVIWVN 687
+ L+ W + ++ G + Y + W ++S I+VN
Sbjct 1702 IVLFRCSFGEGWNYIMADLTVSEPYCSSDDNSTYTDCGSETYAYLLLMSWNIISMYIFVN 1761
Query 688 LFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLS 743
+F++LI+ NF + + + + Y D E L +
Sbjct 1762 MFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMH 1817
Score = 108 bits (269), Expect = 1e-22, Method: Composition-based stats.
Identities = 88/590 (15%), Positives = 191/590 (32%), Gaps = 94/590 (16%)
Query 150 AHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLLRPFFLLQNSSMMKKT 205
F ++ W LV V + +S+ + + +LR L+ + M
Sbjct 487 RAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPSI 546
Query 206 LKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNL------- 258
L+ +++ +P++ +V +L F + G+ +F G +
Sbjct 547 LRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFC 606
Query 259 -----PESLTSLLVLLTTANNPDV----MIPAYSKNRAYAIFF---IVFTVIGSLFLMNL 306
P + + + V + P YSK + A + I F I + +
Sbjct 607 GGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSKCVSNANPYNGRISFDNI-VNSMELV 665
Query 307 LTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVL 366
+ + F + ++ + F + V LL +L
Sbjct 666 FVIMSANTF----TDLMYYTMDSDEMAA-------------CLFFIVCIFVLTIWLLNLL 708
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKE---HPPRPEYQSPFLQ 423
V + S K + + + K + ++ + +
Sbjct 709 IAVLVSSFEIANEEYKKKK----FIYGSRKTGYVARIVTGYWKYFKLKANQTKFPNWSQK 764
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
++ H F ++ +I + + V + + IL + + +E
Sbjct 765 GLA-IYSHVEFIFVILIICD-------IGMRASVKVSTSANCNNILLKTDRGISIVLFIE 816
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
L ++ YL V ++ I TL + L G M LS++ +
Sbjct 817 SLARLV-----LYLPNMWKFLTKPSYVYDFIISIITLVISCLAVEGVLGHMYAWLSIFHI 871
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
+R ++I F + K + + L F ++ ++ V+ F G
Sbjct 872 SRFYRVIISFNLTK--KLWKQILSNGVMIWNLSSFYFFFTFLVAIIMAVY-------FEG 922
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
VI E++ + ++L+ + NW L A +
Sbjct 923 VIPP-------------------EEMADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQ 963
Query 664 RYSGPWS-----KIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
++S S ++F++W+L+S+ + +N+F+ALI E+ K + + Q
Sbjct 964 KHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEVKEEEKRPQQ 1013
>sp|Q96P56|CTSR2_HUMAN Cation channel sperm-associated protein
2 OS=Homo sapiens OX=9606 GN=CATSPER2 PE=1 SV=2
Length=530
Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats.
Identities = 62/329 (19%), Positives = 135/329 (41%), Gaps = 43/329 (13%)
Query 414 RPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL-VLDADVLPAERDDFILGIL 472
R + P A ++ F + N + + V + +L++ L +
Sbjct 90 RCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVA 149
Query 473 NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP 532
++ ++LE+LLK + + NVFD ++T++ L+ E+ L
Sbjct 150 AWFILLIFILEILLKWLS-NFSVFWKSAWNVFDFVVTMLSLLPEVVVL------------ 196
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYV 592
VG+ ++L + V R L+++ + + ++ ++ +++M +L++ +Y+
Sbjct 197 --VGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYI 254
Query 593 FAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV 652
FA+ G+ +F + LEY F D +LVT++ L +
Sbjct 255 FAVTGVYVFS-----------------EYTRSPRQDLEYHVF-FSDLPNSLVTVFILFTL 296
Query 653 NNWQVFLD---AYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFL------HKWDP 703
++W L S +S IYF+LW L+ S+I+ ++ +A+++ NF ++
Sbjct 297 DHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMA 356
Query 704 RSHLQPLAGTPEATYQMTVELLFRDILEE 732
R +Q A + + + + L
Sbjct 357 RREVQLKADMFKRQIIQRRKNMSHEALTS 385
Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats.
Identities = 62/254 (24%), Positives = 116/254 (46%), Gaps = 11/254 (4%)
Query 93 ILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHF 152
I+FL F+ T L ++ P LT V +L+ + +L ++ F
Sbjct 114 IIFLVFLNT-IILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVF 172
Query 153 QKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP-----LRIRRLLRPFFLLQNSSMMKKTLK 207
K+ W + VV ++SL+ V L V + LRI R+LR LL ++ +
Sbjct 173 WKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIIL 232
Query 208 CIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLV 267
+ +L M + +LL I +F + G+ +F+ + QD E +F +LP SL ++ +
Sbjct 233 VLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFI 292
Query 268 LLTTANN----PDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSL 323
L T + DV +I+FI++ ++GS+ +++ A++ + F+ + K L
Sbjct 293 LFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQN-IRKEL 351
Query 324 QTSLFRRRLGTRAA 337
+ RR + +A
Sbjct 352 NEEMARREVQLKAD 365
>sp|O73707|CAC1C_CHICK Voltage-dependent L-type calcium channel
subunit alpha-1C (Fragment) OS=Gallus gallus OX=9031 GN=CACNA1C
PE=2 SV=1
Length=177
Score = 112 bits (280), Expect = 3e-27, Method: Composition-based stats.
Identities = 29/205 (14%), Positives = 74/205 (36%), Gaps = 48/205 (23%)
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
L VV +++I+ V + V R ++++ + +
Sbjct 2 LIVVGSIVDIAITEVNNAEENSRIS-----------ITFFRLFRVMRLVKLLSRGEGIRT 50
Query 568 VASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
+ T + Q + ++V++++++A+IG+ +F + +
Sbjct 51 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI------------------ALNDT 92
Query 628 QLEYWANNFDDFAAALVTLWNLMVVNNWQVFL-------------------DAYRRYSGP 668
NNF F A++ L+ WQ + +A
Sbjct 93 TEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPDKKCDPDSEPANSTEADHSCGSS 152
Query 669 WSKIYFVLWWLVSSVIWVNLFLALI 693
++ YF+ ++++ + + ++LF+A+I
Sbjct 153 FAVFYFISFYMLCAFLIIDLFVAVI 177
Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats.
Identities = 32/176 (18%), Positives = 67/176 (38%), Gaps = 27/176 (15%)
Query 163 VVLVVSLVDWTV-------SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+++V S+VD + S + R+ R++R LL ++ L S
Sbjct 2 LIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQA 61
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+ V LL+ + ++ + GM +F +D + R FQ P+++ L T
Sbjct 62 LPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQ 121
Query 276 DVMIPAYS--------------------KNRAYAIFFIVFTVIGSLFLMNLLTAII 311
++M+ + +FI F ++ + +++L A+I
Sbjct 122 EIMLACLPDKKCDPDSEPANSTEADHSCGSSFAVFYFISFYMLCAFLIIDLFVAVI 177
>sp|O73705|CAC1A_CHICK Voltage-dependent P/Q-type calcium channel
subunit alpha-1A (Fragment) OS=Gallus gallus OX=9031 GN=CACNA1A
PE=2 SV=1
Length=171
Score = 99.8 bits (247), Expect = 5e-23, Method: Composition-based stats.
Identities = 27/162 (17%), Positives = 60/162 (37%), Gaps = 29/162 (18%)
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F
Sbjct 25 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG--- 81
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR-- 663
N E NNF F AL+ L+ W + +
Sbjct 82 ------------NIGIEEEDDESAITQHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSG 129
Query 664 ------------RYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++ YFV + + S + +NLF+A+I
Sbjct 130 KPCDENSGIKEDECGNEFAYFYFVSFIFLCSFLMLNLFVAVI 171
Score = 63.2 bits (152), Expect = 3e-10, Method: Composition-based stats.
Identities = 31/146 (21%), Positives = 57/146 (39%), Gaps = 18/146 (12%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAG--- 240
LR+ R R LL+ ++ L S + V LL+A+ ++ + GM +F
Sbjct 26 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGI 85
Query 241 GKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS---------------KN 285
++DD + F+ ++L L T ++M+ S N
Sbjct 86 EEEDDESAITQHNNFRTFFQALMLLFRSATGEAWHEIMLSCLSGKPCDENSGIKEDECGN 145
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAII 311
+F+ F + S ++NL A+I
Sbjct 146 EFAYFYFVSFIFLCSFLMLNLFVAVI 171
>sp|O73706|CAC1B_CHICK Voltage-dependent N-type calcium channel
subunit alpha-1B (Fragment) OS=Gallus gallus OX=9031 GN=CACNA1B
PE=2 SV=1
Length=159
Score = 98.6 bits (244), Expect = 9e-23, Method: Composition-based stats.
Identities = 26/162 (16%), Positives = 61/162 (38%), Gaps = 32/162 (20%)
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
L + R ++++ + ++ T + + + ++ ++++++AIIG+ +F +
Sbjct 16 FLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI- 74
Query 606 VALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRY 665
+ E NNF F AL+ L+ W + +
Sbjct 75 -----------------ALNDETSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSN 117
Query 666 --------------SGPWSKIYFVLWWLVSSVIWVNLFLALI 693
++ YFV + + S + +NLF+A+I
Sbjct 118 RACDPLSGLTKNECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 159
Score = 67.1 bits (162), Expect = 1e-11, Method: Composition-based stats.
Identities = 30/143 (21%), Positives = 55/143 (38%), Gaps = 15/143 (10%)
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR+ R R LL+ ++ L S + V LL+A+ ++ + GM +F
Sbjct 17 LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIAL 76
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS---------------KNRAY 288
+D R F+ ++L L T ++M+ S +
Sbjct 77 NDETSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNRACDPLSGLTKNECGSDFA 136
Query 289 AIFFIVFTVIGSLFLMNLLTAII 311
+F+ F + S ++NL A+I
Sbjct 137 YFYFVSFIFLCSFLMLNLFVAVI 159
>sp|Q86XQ3|CTSR3_HUMAN Cation channel sperm-associated protein
3 OS=Homo sapiens OX=9606 GN=CATSPER3 PE=1 SV=1
Length=398
Score = 93.6 bits (231), Expect = 5e-19, Method: Composition-based stats.
Identities = 48/270 (18%), Positives = 102/270 (38%), Gaps = 40/270 (15%)
Query 425 AQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM 484
+ +I ++ + S F+ L R +L F+ E+
Sbjct 39 CRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSEL 98
Query 485 LLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
+KV+ + Y N+ D ++ +V+ + + L + D
Sbjct 99 SMKVY-VDPINYWKNGYNLLDVIIIIVMFL---------PYALRQLMGKQFTYLYIADGM 148
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGV 604
+ L R L++I + + + + V V + + +L ++ Y+FAI+G LF
Sbjct 149 QSL------RILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG-- 200
Query 605 IVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRR 664
+P NG N+ + AAA TL++L V+ W
Sbjct 201 ----------SPDNGDHD------------NWGNLAAAFFTLFSLATVDGWTDLQKQLDN 238
Query 665 YSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
S+ + +++ L++S I++N+F+ +++
Sbjct 239 REFALSRAFTIIFILLASFIFLNMFVGVMI 268
Score = 84.8 bits (208), Expect = 5e-16, Method: Composition-based stats.
Identities = 53/327 (16%), Positives = 117/327 (36%), Gaps = 23/327 (7%)
Query 76 RYYSNVCQRTLSFTIFLILF-LAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLL 134
+ + C+ + I F + I T +S + L E E+ +
Sbjct 33 KRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVS 92
Query 135 VFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTV----SLSLVCHEPLRIRRLL 190
+ ++LS+K ++ KN + L +++++V + + + + L
Sbjct 93 ICTSELSMK-VYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSL 151
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L+ S ++ + + ++ +ASV LLL + + +F + G LF D
Sbjct 152 RILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFG------SPDNG 205
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFF-IVFTVIGSLFLMNLLTA 309
+ NL + +L L T D+ ++ A + F I+F ++ S +N+
Sbjct 206 DHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVG 265
Query 310 IIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKV 369
++ + T R+ E ++GE Q + L+ + +
Sbjct 266 VM----------IMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNA 315
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEF 396
S + K + + ++F
Sbjct 316 DCTSFSELVENFKKTLSHTDPMVLDDF 342
>sp|Q80W99|CTSR3_MOUSE Cation channel sperm-associated protein
3 OS=Mus musculus OX=10090 GN=Catsper3 PE=1 SV=2
Length=395
Score = 90.6 bits (223), Expect = 5e-18, Method: Composition-based stats.
Identities = 45/272 (17%), Positives = 100/272 (37%), Gaps = 40/272 (15%)
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL 482
+ Q F ++ + + + LVL + + F+ Y+
Sbjct 37 KECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTFEVSELFFVSVYVC 96
Query 483 EMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWD 542
E L+KV+ Y N+ + +++++ L + H + G+ S
Sbjct 97 EFLMKVYVD-PITYWKDGYNI--LDVIILIILTIPYLLRKIKGNHSAYLHFADGIQS--- 150
Query 543 MTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
R L++I + + + V V + + +L ++ +VFAI+G LF
Sbjct 151 ----------LRILKLISYSRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFG 200
Query 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAY 662
N+ + A+A TL++L V+ W +
Sbjct 201 ------------------------VTDRGDLENWGNLASAFFTLFSLATVDGWTDLQEEL 236
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+ S+ + +L+ L++S I++N+F+ +++
Sbjct 237 DKRKFTVSRAFTILFILLASFIFLNMFVGVMI 268
Score = 70.5 bits (171), Expect = 2e-11, Method: Composition-based stats.
Identities = 43/270 (16%), Positives = 96/270 (36%), Gaps = 15/270 (6%)
Query 83 QRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSV 142
++ + T F I+ + + T S L E E+ + V+ + +
Sbjct 44 RKVIKSTFFQIVMITTVTTNSFLLVLGT---NYDIQFEFFRTFEVSELFFVSVYVCEFLM 100
Query 143 KGYLFGWAHFQKNLWLLGYLVVLVVSLVDW----TVSLSLVCHEPLRIRRLLRPFFLLQN 198
K + K+ + + +++L++ + + + LR L+
Sbjct 101 K-VYVDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISY 159
Query 199 SSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNL 258
S ++ + + ++ +ASV LL + + +F + G LF DR L + NL
Sbjct 160 SRGIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFG------VTDRGDLENWGNL 213
Query 259 PESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFF-IVFTVIGSLFLMNLLTAIIYSQFRG 317
+ +L L T D+ + + F I+F ++ S +N+ ++
Sbjct 214 ASAFFTLFSLATVDGWTDLQEELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTED 273
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGE 347
+ K + R L +++ E
Sbjct 274 SMKKFERDLTLERNLAIMEEKQIILKRQQE 303
>sp|H2LRU7|PKD2_ORYLA Polycystin-2 OS=Oryzias latipes OX=8090
GN=pkd2 PE=1 SV=2
Length=901
Score = 83.6 bits (205), Expect = 3e-15, Method: Composition-based stats.
Identities = 41/289 (14%), Positives = 109/289 (38%), Gaps = 44/289 (15%)
Query 468 ILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA------ 521
+ + C+F++YY++E +L++ L Y N D L+ + +V I ++
Sbjct 417 VCEVAFCLFVLYYVVEEVLEIHIHRL-HYFKNLWNCLDVLIVTLSVVAIIMSITRAAMGG 475
Query 522 -VYRLPHPGWRPEMVGLLSLWDMTR-----MLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+ + L+ + ++ + + I K M+ +++T+
Sbjct 476 DLLKGLENYTSHTSFDSLANLQVQFNNMAAVIVFFCWVKLFKFINFNKTMSQLSTTMSRC 535
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
+++ F + +++ +A + +F N+
Sbjct 536 AKDLVGFAIMFFIIFLAYAQLAYLVFG----------------------------TQVND 567
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
F F ++ T + +++ + F + + + IYF+ + L I +N+FLA+I +
Sbjct 568 FSTFQGSVFTQFRIILGD--FDFFE-IKEANPVLGPIYFITFVLFIFFILMNMFLAIIND 624
Query 696 NFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ + + + + + L + L++ D++++ L Q
Sbjct 625 TYSEVKADMAQHRSEMEMTDFIKKGCTKALVKLRLKKTTVDDISDSLRQ 673
Score = 54.7 bits (130), Expect = 3e-06, Method: Composition-based stats.
Identities = 51/361 (14%), Positives = 121/361 (34%), Gaps = 51/361 (14%)
Query 99 IETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWL 158
+ T + ++Y ++ W+ G+ E L +L + + ++ H+ KNLW
Sbjct 393 VLTSWQFQTLRLIKYVSS-WDYFVGVCEVAFCLFVLYYVVEEVLE-IHIHRLHYFKNLWN 450
Query 159 LGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMAS 218
++++ +S+V +S++ R L+N + + + + +
Sbjct 451 CLDVLIVTLSVVAIIMSIT-------RAAMGGDLLKGLENYTS-HTSFDSLANLQVQFNN 502
Query 219 VGLLLAIH----------------------------LCLFTMFGMLLF-AGGKQDDGQDR 249
+ ++ L F + ++F A +
Sbjct 503 MAAVIVFFCWVKLFKFINFNKTMSQLSTTMSRCAKDLVGFAIMFFIIFLAYAQLAYLVFG 562
Query 250 ERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTA 309
++ F S+ + ++ + D + I+FI F + LMN+ A
Sbjct 563 TQVNDFSTFQGSVFTQFRIIL--GDFDFFEIKEANPVLGPIYFITFVLFIFFILMNMFLA 620
Query 310 IIYSQFRGYLMK------SLQTSLFRRRLGTRAAFEVLSSMV----GEGGAFPQAVGVKP 359
II + ++ + F ++ T+A ++ +
Sbjct 621 IINDTYSEVKADMAQHRSEMEMTDFIKKGCTKALVKLRLKKTTVDDISDSLRQAGGKLNY 680
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
LLQ L++ + QA+ K G + L+ + Q++ ++L++ R
Sbjct 681 DELLQDLKEKGHTEAEIQAIFAKYDQDGDLELTEHDHQQMRDDLEKEREDLDLERNSLTR 740
Query 420 P 420
P
Sbjct 741 P 741
>sp|Q6IVV8|PKD2_DANRE Polycystin-2 OS=Danio rerio OX=7955 GN=pkd2
PE=1 SV=1
Length=904
Score = 77.5 bits (189), Expect = 3e-13, Method: Composition-based stats.
Identities = 44/285 (15%), Positives = 104/285 (36%), Gaps = 47/285 (16%)
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST-------------L 520
C+F++YYL+E L++ LR Y N D L+ + + I L
Sbjct 417 CLFVLYYLVEEALEIRLHRLR-YFKSLWNCLDVLIVALSVPAIIMNICRTSAVSHRLHFL 475
Query 521 AVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+P + P + ++ ++ L + + I K M +++T+ +++
Sbjct 476 LENHSTYPNFEPLARLQVHFNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLM 535
Query 581 AFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFA 640
F + +V+ +A + +F N+F F
Sbjct 536 GFAIMFFIVFLAYAQLAYLVFG----------------------------TQVNDFSTFQ 567
Query 641 AALVTLWNLMVVN-NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
A + T + +++ + ++ +A IYF + +I +N+FLA+I + +
Sbjct 568 ACIFTQFRIILGDFDFSEIEEADSVLGP----IYFTTFVFFIFMILLNMFLAIINDTYSE 623
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ + + + + + L++ +++ + L Q
Sbjct 624 VKADMAQQRSEMEITDLIKKSYNRAMVKLKLKKSSINDIPDSLQQ 668
Score = 52.4 bits (124), Expect = 2e-05, Method: Composition-based stats.
Identities = 49/365 (13%), Positives = 117/365 (32%), Gaps = 46/365 (13%)
Query 101 TPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLG 160
PS T + + W+ G+ E L +L + + +++ + K+LW
Sbjct 388 VPSWQFQTVRLLRYVSSWDYFVGMCEVSFCLFVLYYLVEEALE-IRLHRLRYFKSLWNCL 446
Query 161 YLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVG 220
++++ +S+ +++ R+ LL N + + L+ +L +
Sbjct 447 DVLIVALSVPAIIMNICRTSAVSHRLHFLLENHSTYPNFEPLAR-LQVHFNNLAAIIVFL 505
Query 221 LLLAIHLCL----------------------FTMFGMLLF-AGGKQDDGQDRERLTYFQN 257
+ + + F + ++F A + ++ F
Sbjct 506 SWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQVNDFST 565
Query 258 LPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRG 317
+ + ++ + D + + I+F F + L+N+ AII +
Sbjct 566 FQACIFTQFRIIL--GDFDFSEIEEADSVLGPIYFTTFVFFIFMILLNMFLAIINDTYSE 623
Query 318 YLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHK- 376
Q + + + + ++ P +L Q K+ D +
Sbjct 624 VKADMAQQRSEMEITDL--IKKSYNRAMVKLKLKKSSINDIPDSLQQAAGKLSFDELRQD 681
Query 377 -----------QAMMEKVRSYGSVLLSAEEFQKLFNELDRS-----VVKEHPPRPEYQSP 420
+A+ K G L+ E Q++ ++L++ + PRP
Sbjct 682 LRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQMRDDLEKEREDLDLEHSSLPRPASGRS 741
Query 421 FLQSA 425
F +S
Sbjct 742 FSRSQ 746
>sp|A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger
OS=Strongylocentrotus purpuratus OX=7668 GN=SLC9C1 PE=1 SV=1
Length=1325
Score = 68.6 bits (166), Expect = 2e-10, Method: Composition-based stats.
Identities = 34/168 (20%), Positives = 66/168 (39%), Gaps = 20/168 (12%)
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+V D + +++ ++ + ++ +L P P+Y+ +
Sbjct 616 EVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISEKKIAAIPMPKYK--LGKLMYK 673
Query 428 LFGHYYFDYLGNLIALANLVSICVFLVLD-----------------ADVLPAERDDFILG 470
+ H F+ N+ + N+V I + V+ ++ ++ + L
Sbjct 674 ICHHMAFEVTINIAIVLNIVPIIMEFVVQDKMASVSTMAAPGSTVSSEPSSLQKIEDALR 733
Query 471 ILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIS 518
I N VF V Y +E ++K+ LG R Y+ N FD + VV LV I
Sbjct 734 ISNYVFFVIYAIEAIVKILGLG-RHYIVSHWNKFDAFILVVALVDIII 780
>sp|P17970|KCNAB_DROME Potassium voltage-gated channel protein
Shab OS=Drosophila melanogaster OX=7227 GN=Shab PE=1 SV=2
Length=985
Score = 68.6 bits (166), Expect = 2e-10, Method: Composition-based stats.
Identities = 53/319 (17%), Positives = 111/319 (35%), Gaps = 38/319 (12%)
Query 45 CIDQAVVFIEDAIQYRSINHR----VDASSMWLYRRYYSNVCQR---TLSFTIFLILFLA 97
+ V E + S+ R Y++Y + ++ + + + ++ +
Sbjct 384 HQRKENVHEEMRKEAESLRQRDEEEFGEGKFSEYQKYLWELLEKPNTSFAARVIAVISIL 443
Query 98 FIETPSSLTSTADVRYRAAPWEPPCGL---TESVEVLCLLVFAADLSVKGYLF-GWAHFQ 153
FI + + + VE +C+ F + ++ F
Sbjct 444 FIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFF 503
Query 154 KNLWLLGYLVVLV---VSLVDWTVSLSLV--------CHEPLRIRRLLRPFFLLQNSSMM 202
K + L+ ++ VSL + + + RI R+LR L ++S+ +
Sbjct 504 KGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRVLKLARHSTGL 563
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESL 262
+ +R S E+ + L LA+ + +F+ + E+ T F ++PE+
Sbjct 564 QSLGFTLRNSYKELGLLMLFLAMGVLIFSSLA---------YFAEKDEKDTKFVSIPEAF 614
Query 263 TSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS 322
+ +TT D+ + V + G L + L II + F +
Sbjct 615 WWAGITMTTVGYGDICP----TTALGKVIGTVCCICGVLVVA-LPIPIIVNNFAEFYKNQ 669
Query 323 L--QTSLFRRRLGTRAAFE 339
+ + +L RR RA E
Sbjct 670 MRREKALKRREALDRAKRE 688
Score = 55.1 bits (131), Expect = 2e-06, Method: Composition-based stats.
Identities = 31/263 (12%), Positives = 88/263 (33%), Gaps = 16/263 (6%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G+ + + + L+ + ++ L+S + ++ + + E
Sbjct 342 LNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESL 401
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV- 454
Q+ E E+ +Y L+ F + L + + +++ + +
Sbjct 402 RQRDEEEFGEGKFSEYQ---KYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 458
Query 455 -LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
L +D+ L ++ V I ++ LE +L+ A F G L ++ L
Sbjct 459 QLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSAS------PDKWKFFKGGLNIIDL 512
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+ + L + + ++ ++ + R L++ + + T+
Sbjct 513 LAILPYFVSLFLLETNKNATD-QFQDVRRVVQVFRIMRILRVLKLARHSTGLQSLGFTLR 571
Query 574 GLVQNMRAFGGILVVVYYVFAII 596
+ + L + +F+ +
Sbjct 572 NSYKELGLLMLFLAMGVLIFSSL 594
>sp|Q17ST2|KCNA7_MOUSE Potassium voltage-gated channel subfamily
A member 7 OS=Mus musculus OX=10090 GN=Kcna7 PE=2 SV=2
Length=489
Score = 67.1 bits (162), Expect = 3e-10, Method: Composition-based stats.
Identities = 48/194 (25%), Positives = 77/194 (40%), Gaps = 28/194 (14%)
Query 95 FLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF-GWAHFQ 153
FLA + S + P +P VE LC+ F+ +L V+ A F
Sbjct 219 FLARLNGSSPMPGA-------PPRQPFNDPFFVVETLCICWFSFELLVRLVACPSKAVFF 271
Query 154 KNLWLLGYLVVLVVSLVDWTVSL-----------SLVCHEPLRIRRLLRPFFLLQNSSMM 202
KN+ L V ++ V L SL +R+ R+ R F L ++S +
Sbjct 272 KNVMNLIDFVAILPYFVALGTELARQRGVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGL 331
Query 203 KKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESL 262
+ + +R S+ E+ L I G++LF+ DR T+F ++PES
Sbjct 332 QILGQTLRASMRELG-----LLIFFLF---IGVVLFSSAVYFAEVDRVD-THFTSIPESF 382
Query 263 TSLLVLLTTANNPD 276
+V +TT D
Sbjct 383 WWAVVTMTTVGYGD 396
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 23/152 (15%), Positives = 55/152 (36%), Gaps = 17/152 (11%)
Query 461 PAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVLLVLEIST 519
P + + ++ + I ++ E+L+++ A + + N+ D + + V +
Sbjct 234 PRQPFNDPFFVVETLCICWFSFELLVRLVACPSKAVFFKNVMNLIDFVAILPYFVALGTE 293
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
LA G+ +L ++ + R RI + + L +M
Sbjct 294 LA-----------RQRGVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASM 342
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
R G ++ ++ IG+ LF + +
Sbjct 343 RELGLLIFFLF-----IGVVLFSSAVYFAEVD 369
>sp|Q96RP8|KCNA7_HUMAN Potassium voltage-gated channel subfamily
A member 7 OS=Homo sapiens OX=9606 GN=KCNA7 PE=1 SV=1
Length=456
Score = 62.1 bits (149), Expect = 1e-08, Method: Composition-based stats.
Identities = 43/173 (25%), Positives = 71/173 (41%), Gaps = 21/173 (12%)
Query 116 APWEPPCGLTESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTV 174
P P VE LC+ F+ +L V+ + A F KN+ L V ++ V
Sbjct 200 PPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGT 259
Query 175 SL-----------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
L SL +R+ R+ R F L ++S ++ + +R S+ E+ L
Sbjct 260 ELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELG-----L 314
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
I G++LF+ DR ++F ++PES +V +TT D
Sbjct 315 LIFFLF---IGVVLFSSAVYFAEVDRVD-SHFTSIPESFWWAVVTMTTVGYGD 363
Score = 42.0 bits (97), Expect = 0.021, Method: Composition-based stats.
Identities = 20/133 (15%), Positives = 46/133 (35%), Gaps = 17/133 (13%)
Query 480 YLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ E+L+++ + + N+ D + + V + LA G+
Sbjct 220 FSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELA-----------RQRGVG 268
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI 598
+L ++ + R RI + + L +MR G ++ ++ IG+
Sbjct 269 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLF-----IGV 323
Query 599 NLFRGVIVALPGN 611
LF + +
Sbjct 324 VLFSSAVYFAEVD 336
>sp|Q9TT17|KCNS3_RABIT Potassium voltage-gated channel subfamily
S member 3 OS=Oryctolagus cuniculus OX=9986 GN=KCNS3 PE=2
SV=1
Length=491
Score = 62.1 bits (149), Expect = 1e-08, Method: Composition-based stats.
Identities = 41/255 (16%), Positives = 96/255 (38%), Gaps = 18/255 (7%)
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF 429
+ + + ++ + S S EE EL++ + +++ +
Sbjct 123 ERKEENHEKDWDQKSNDVSTDTSFEESSVFEKELEKFDQLRFGQLRKKIWIRMENPAYCL 182
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
+ LA++V++CV + + E DD +L + I ++ E+ +++
Sbjct 183 SAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVRLV 242
Query 490 ALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
A + + P N+ D V ++ +TLAV + +M +++
Sbjct 243 AAPCQKKFWKNPLNIIDF----VSIIPFYATLAVDTKEEESED--------IENMGKVVQ 290
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVAL 608
+L + R RI+ + + S L + G +L+ F +GI++F +I ++
Sbjct 291 ILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLL-----FLSVGISIFSVLIYSV 345
Query 609 PGNSSLAPANGSAPC 623
+ + C
Sbjct 346 EKDDHTSSLTSIPIC 360
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 25/121 (21%), Positives = 51/121 (42%), Gaps = 11/121 (9%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVVLV---VSLVDWTVSLS-- 177
+ E VE+ C+ F +L+V+ F KN + V ++ +L T
Sbjct 221 VLEGVEIACIAWFTGELAVRLVAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESE 280
Query 178 -----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
+ LR+ R+ R L ++S ++ +R S E+ + L L++ + +F++
Sbjct 281 DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSV 340
Query 233 F 233
Sbjct 341 L 341
>sp|O88759|KCNS3_RAT Potassium voltage-gated channel subfamily
S member 3 OS=Rattus norvegicus OX=10116 GN=Kcns3 PE=1 SV=1
Length=491
Score = 61.3 bits (147), Expect = 2e-08, Method: Composition-based stats.
Identities = 42/254 (17%), Positives = 98/254 (39%), Gaps = 19/254 (7%)
Query 359 PQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ 418
+ + + + SH++ +K + S EE EL++ +
Sbjct 113 IDSCCSSRYQERKEESHEKDWDQKSNDVSTDS-SFEESSLFEKELEKFDELRFGQLRKKI 171
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
+++ + + LA++V++CV + + E DD +L + I
Sbjct 172 WIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIA 231
Query 479 YYLLEMLLKVFAL-GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ +++ A + + P N+ D V ++ +TLAV
Sbjct 232 WFTGELAIRLVAAPSQKKFWKNPLNIIDF----VSIIPFYATLAVDTKEEESED------ 281
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ +M +++ +L + R RI+ + + S L + G +L+ F +G
Sbjct 282 --IENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLL-----FLSVG 334
Query 598 INLFRGVIVALPGN 611
I++F +I ++ +
Sbjct 335 ISIFSVLIYSVEKD 348
Score = 46.3 bits (108), Expect = 0.001, Method: Composition-based stats.
Identities = 24/121 (20%), Positives = 51/121 (42%), Gaps = 11/121 (9%)
Query 124 LTESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV---VSLVDWTVSLS-- 177
+ E VE+ C+ F +L+++ F KN + V ++ +L T
Sbjct 221 VLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESE 280
Query 178 -----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
+ LR+ R+ R L ++S ++ +R S E+ + L L++ + +F++
Sbjct 281 DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSV 340
Query 233 F 233
Sbjct 341 L 341
>sp|A4K2S2|KCNS1_LEMCA Potassium voltage-gated channel subfamily
S member 1 OS=Lemur catta OX=9447 GN=KCNS1 PE=3 SV=1
Length=529
Score = 61.3 bits (147), Expect = 2e-08, Method: Composition-based stats.
Identities = 39/255 (15%), Positives = 89/255 (35%), Gaps = 26/255 (10%)
Query 376 KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
+A E + SV + +E + EL R +++ + F
Sbjct 164 PRAWDEDSDTPSSVDPNPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFS 223
Query 436 YLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIVYY 480
+ + LA++ ++C+ + + RDD +L L I ++
Sbjct 224 CVSIGVVLASIAAMCIHSLPEYQAREAAAAVATVAAGRSAEDVRDDPVLRRLEYFCIAWF 283
Query 481 LLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
E+ ++ A R + +P N+ D ++ VL + + G
Sbjct 284 SFEVSSRLLLAPSTRNFFCHPLNLID-----IVSVLPFYLTLLASVALGGNNHGGTSGEE 338
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
L + +++ + + R R++ + + S L + R G +L+ + +G++
Sbjct 339 LGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVGVS 393
Query 600 LFRGVIVALPGNSSL 614
+F GV +
Sbjct 394 VFSGVAYTAEKEEDV 408
Score = 42.0 bits (97), Expect = 0.019, Method: Composition-based stats.
Identities = 43/241 (18%), Positives = 94/241 (39%), Gaps = 33/241 (14%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC-- 180
+ +E C+ F+ ++S + +F + L +V ++ + S++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLASVALGGNN 330
Query 181 ---------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 HGGTSGEELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV 390
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
G+ +F+G ++E F +P V +TT DV+ +
Sbjct 391 --------GVSVFSGVAYT--AEKEEDVGFDTIPACWWWGTVSMTTVGYGDVVPVTLAGK 440
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMV 345
A + ++G + ++ L II+++F + + R G R ++LSS+
Sbjct 441 LAASG-----CILGGILVVALPITIIFNKFSHFYQRQKALEAAVRNSGHREFEDLLSSVD 495
Query 346 G 346
G
Sbjct 496 G 496
>sp|Q8BQZ8|KCNS3_MOUSE Potassium voltage-gated channel subfamily
S member 3 OS=Mus musculus OX=10090 GN=Kcns3 PE=2 SV=1
Length=491
Score = 60.9 bits (146), Expect = 3e-08, Method: Composition-based stats.
Identities = 34/172 (20%), Positives = 75/172 (44%), Gaps = 18/172 (10%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL-GLRGYLSY 499
+ LA++V++CV + + E DD +L + I ++ E+ +++ A + +
Sbjct 194 VVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKN 253
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
P N+ D V ++ +TLAV + +M +++ +L + R RI+
Sbjct 254 PLNIIDF----VSIIPFYATLAVDTKEEESED--------IENMGKVVQILRLMRIFRIL 301
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
+ + S L + G +L+ F +GI++F +I ++ +
Sbjct 302 KLARHSVGLRSLGATLRHSYHEVGLLLL-----FLSVGISIFSVLIYSVEKD 348
Score = 46.3 bits (108), Expect = 0.001, Method: Composition-based stats.
Identities = 24/121 (20%), Positives = 51/121 (42%), Gaps = 11/121 (9%)
Query 124 LTESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV---VSLVDWTVSLS-- 177
+ E VE+ C+ F +L+++ F KN + V ++ +L T
Sbjct 221 VLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESE 280
Query 178 -----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
+ LR+ R+ R L ++S ++ +R S E+ + L L++ + +F++
Sbjct 281 DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSV 340
Query 233 F 233
Sbjct 341 L 341
>sp|Q4G0N8|SL9C1_HUMAN Solute carrier family 9 member C1 OS=Homo
sapiens OX=9606 GN=SLC9C1 PE=1 SV=2
Length=1177
Score = 61.3 bits (147), Expect = 3e-08, Method: Composition-based stats.
Identities = 28/162 (17%), Positives = 71/162 (44%), Gaps = 6/162 (4%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
+ F + + F+++G L+ L N+ + + +V+ L N
Sbjct 595 PSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSE----LKHTNYC 650
Query 476 FIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
F+ Y+LE LLK+ A+ + + S+ N+F+ +T++ +L + + + + + E++
Sbjct 651 FLTLYILEALLKIAAMR-KDFFSHAWNIFELAITLIG-ILHVILIEIDTIKYIFNETEVI 708
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ + R+L + + + K M+ + G+++
Sbjct 709 VFIKVVQFFRILRIFKLIAPKLLQIIDKRMSHQKTFWYGILK 750
Score = 37.4 bits (85), Expect = 0.59, Method: Composition-based stats.
Identities = 17/148 (11%), Positives = 47/148 (32%), Gaps = 26/148 (18%)
Query 68 ASSMWLYRRYYSNVCQRTL-----SFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPC 122
+ ++ +C + +L++ + S S +V Y +
Sbjct 590 KEKEGPSKYFFFRICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHSE------ 643
Query 123 GLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVS------- 175
+ L ++ + +K F + W + L + ++ ++ +
Sbjct 644 --LKHTNYCFLTLYILEALLKIAAM-RKDFFSHAWNIFELAITLIGILHVILIEIDTIKY 700
Query 176 -----LSLVCHEPLRIRRLLRPFFLLQN 198
+V + ++ R+LR F L+
Sbjct 701 IFNETEVIVFIKVVQFFRILRIFKLIAP 728
>sp|Q7TSH7|KCNF1_MOUSE Voltage-gated potassium channel regulatory
subunit KCNF1 OS=Mus musculus OX=10090 GN=Kcnf1 PE=1 SV=1
Length=493
Score = 60.5 bits (145), Expect = 3e-08, Method: Composition-based stats.
Identities = 43/271 (16%), Positives = 95/271 (35%), Gaps = 23/271 (8%)
Query 22 WPAGLTTYRSIQVGPGAAARWDLCI--DQAVVFIEDA-IQYRSINHRVDASSMWLYRRYY 78
W L + R +L + + ++D + R +W +
Sbjct 116 WKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKP 175
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ C + + +L L T + E+VE C+ F
Sbjct 176 ESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTL 235
Query 139 DLSVKGYL----FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-------CHEPLRIR 187
+ ++ + +A N+ + ++ VSL + ++ + LRI
Sbjct 236 EYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIM 295
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+ R F L ++SS ++ ++ S E+ + + LA+ + +F+ G +
Sbjct 296 RIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG---------YTME 346
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
T F+++P+S ++ +TT D+
Sbjct 347 QSHPETLFKSIPQSFWWAIITMTTVGYGDIY 377
Score = 52.0 bits (123), Expect = 1e-05, Method: Composition-based stats.
Identities = 31/168 (18%), Positives = 70/168 (42%), Gaps = 17/168 (10%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAE---RDDFILGILNCVFIVYYLLEMLLKVFALG 492
L L+ L + V +C+ + + V+ +E + L + I ++ LE LL++
Sbjct 186 VLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRL---- 241
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
S P N L+ + +V ++ L Y ++ L ++ + + L +
Sbjct 242 ----FSSP-NKLHFALSFMNIVDVLAILPFY--VSLTLTHLGARMMELTNVQQAVQALRI 294
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIG 597
R RI + + + + L ++ + G +L+ + +VF+ +G
Sbjct 295 MRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG 342
>sp|D4ADX7|KCNF1_RAT Voltage-gated potassium channel regulatory
subunit KCNF1 OS=Rattus norvegicus OX=10116 GN=Kcnf1 PE=1
SV=3
Length=493
Score = 60.5 bits (145), Expect = 3e-08, Method: Composition-based stats.
Identities = 43/271 (16%), Positives = 95/271 (35%), Gaps = 23/271 (8%)
Query 22 WPAGLTTYRSIQVGPGAAARWDLCI--DQAVVFIEDA-IQYRSINHRVDASSMWLYRRYY 78
W L + R +L + + ++D + R +W +
Sbjct 116 WKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKP 175
Query 79 SNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
+ C + + +L L T + E+VE C+ F
Sbjct 176 ESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTL 235
Query 139 DLSVKGYL----FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV-------CHEPLRIR 187
+ ++ + +A N+ + ++ VSL + ++ + LRI
Sbjct 236 EYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIM 295
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+ R F L ++SS ++ ++ S E+ + + LA+ + +F+ G +
Sbjct 296 RIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG---------YTME 346
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
T F+++P+S ++ +TT D+
Sbjct 347 QSHPETLFKSIPQSFWWAIITMTTVGYGDIY 377
Score = 52.0 bits (123), Expect = 1e-05, Method: Composition-based stats.
Identities = 31/168 (18%), Positives = 70/168 (42%), Gaps = 17/168 (10%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAE---RDDFILGILNCVFIVYYLLEMLLKVFALG 492
L L+ L + V +C+ + + V+ +E + L + I ++ LE LL++
Sbjct 186 VLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRL---- 241
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
S P N L+ + +V ++ L Y ++ L ++ + + L +
Sbjct 242 ----FSSP-NKLHFALSFMNIVDVLAILPFY--VSLTLTHLGARMMELTNVQQAVQALRI 294
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIG 597
R RI + + + + L ++ + G +L+ + +VF+ +G
Sbjct 295 MRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG 342
>sp|Q9H3M0|KCNF1_HUMAN Voltage-gated potassium channel regulatory
subunit KCNF1 OS=Homo sapiens OX=9606 GN=KCNF1 PE=1 SV=1
Length=494
Score = 60.1 bits (144), Expect = 4e-08, Method: Composition-based stats.
Identities = 32/165 (19%), Positives = 70/165 (42%), Gaps = 20/165 (12%)
Query 125 TESVEVLCLLVFAADLSVKGYL----FGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV- 179
E+VE C+ F + ++ + +A N+ + ++ VSL + ++
Sbjct 222 LENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMME 281
Query 180 ------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
+ LRI R+ R F L ++SS ++ ++ S E+ + + LA+ + +F+
Sbjct 282 LTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSAL 341
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
G + T F+++P+S ++ +TT D+
Sbjct 342 G---------YTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIY 377
Score = 52.8 bits (125), Expect = 8e-06, Method: Composition-based stats.
Identities = 33/168 (20%), Positives = 70/168 (42%), Gaps = 17/168 (10%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAE---RDDFILGILNCVFIVYYLLEMLLKVFALG 492
L L+ L + V +C+ + + VL AE + L + I ++ LE LL++
Sbjct 186 VLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRL---- 241
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
S P N L+ + +V ++ L Y ++ L ++ + + L +
Sbjct 242 ----FSSP-NKLHFALSFMNIVDVLAILPFY--VSLTLTHLGARMMELTNVQQAVQALRI 294
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV---YYVFAIIG 597
R RI + + + + L ++ + G +L+ + +VF+ +G
Sbjct 295 MRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALG 342
>sp|Q8CFS6|KCNV2_MOUSE Potassium voltage-gated channel subfamily
V member 2 OS=Mus musculus OX=10090 GN=Kcnv2 PE=2 SV=1
Length=562
Score = 60.1 bits (144), Expect = 4e-08, Method: Composition-based stats.
Identities = 28/193 (15%), Positives = 72/193 (37%), Gaps = 11/193 (6%)
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAE-----RDDF 467
P+ + ++ NL L ++V++ + V + +
Sbjct 249 PQRQRLWNLMEKPFSSVAAKAMGVATNLFVLISVVALALNTVEEMQHQAEQGTGGGDPRP 308
Query 468 ILGILNCVFIVYYLLEMLLKVFAL-GLRGYLSYPSNVFDGLLTV-VLLVLEISTLAVYRL 525
IL + + + ++ LE LL++ + L+ + N+ D + + L L +
Sbjct 309 ILEHVEMLCVAFFTLEFLLRLASTPNLQRFARSALNLVDLVAILPFYLQLLLECFTSEDQ 368
Query 526 PHPGWRP---EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAF 582
H P ++ + + + ++L ++ + R RI+ + + + L Q +
Sbjct 369 RHNKDSPREHDLETVGRVGKVGQVLRIMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQV 428
Query 583 G-GILVVVYYVFA 594
G +L + +F+
Sbjct 429 GCLMLFITMGIFS 441
Score = 33.9 bits (76), Expect = 5.7, Method: Composition-based stats.
Identities = 50/276 (18%), Positives = 100/276 (36%), Gaps = 49/276 (18%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRA---APWEPPCGLTESVEVLCLLVFAADLSVKGYL 146
+ LF+ +L + +++++A P + E VE+LC+ F + ++
Sbjct 272 VATNLFVLISVVALALNTVEEMQHQAEQGTGGGDPRPILEHVEMLCVAFFTLEFLLRLAS 331
Query 147 F-GWAHFQKNLWLLGYLVVLVVSLVDW-----------------------TVSLSLVCHE 182
F ++ L LV ++ + TV +
Sbjct 332 TPNLQRFARSALNLVDLVAILPFYLQLLLECFTSEDQRHNKDSPREHDLETVGRVGKVGQ 391
Query 183 PLRIRRLLRPFFLL---QNSSMMKKTLKCIRWSLPEMASVG-LLLAIHLCLFTMFGMLLF 238
LRI RL+R F +L ++S+ ++ +R VG L+L I + +F+ F
Sbjct 392 VLRIMRLMRIFRILKLARHSTGLRAFGFTLRQC---YQQVGCLMLFITMGIFS------F 442
Query 239 AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVI 298
+ D T F ++ + V ++T D+ + F +
Sbjct 443 SAAVYSVEHDVPG-TNFTSILHAWWWAAVSISTVGYGDMYPETHLGRL-----FAFLCIA 496
Query 299 GSLFLMNLLTAIIYSQFRGYLMKSL---QTSLFRRR 331
+ L + +I+Y++F Y K T++ R R
Sbjct 497 FGIILNGMPISILYNKFSDYYSKLKAYEYTAIRRER 532
>sp|Q9BQ31|KCNS3_HUMAN Potassium voltage-gated channel subfamily
S member 3 OS=Homo sapiens OX=9606 GN=KCNS3 PE=1 SV=3
Length=491
Score = 60.1 bits (144), Expect = 4e-08, Method: Composition-based stats.
Identities = 35/184 (19%), Positives = 77/184 (42%), Gaps = 18/184 (10%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG-YLSY 499
+ LA++V++CV + + E DD +L + I ++ E+ +++ A + +
Sbjct 194 VVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVRLAAAPCQKKFWKN 253
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
P N+ D V ++ +TLAV + +M +++ +L + R RI+
Sbjct 254 PLNIIDF----VSIIPFYATLAVDTKEEESED--------IENMGKVVQILRLMRIFRIL 301
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
+ + S L + G +L+ F +GI++F +I ++ + +
Sbjct 302 KLARHSVGLRSLGATLRHSYHEVGLLLL-----FLSVGISIFSVLIYSVEKDDHTSSLTS 356
Query 620 SAPC 623
C
Sbjct 357 IPIC 360
Score = 43.6 bits (101), Expect = 0.007, Method: Composition-based stats.
Identities = 25/121 (21%), Positives = 51/121 (42%), Gaps = 11/121 (9%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFG-WAHFQKNLWLLGYLVVLV---VSLVDWTVSLS-- 177
+ E VE+ C+ F +L+V+ F KN + V ++ +L T
Sbjct 221 VLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESE 280
Query 178 -----LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
+ LR+ R+ R L ++S ++ +R S E+ + L L++ + +F++
Sbjct 281 DIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSV 340
Query 233 F 233
Sbjct 341 L 341
>sp|P15387|KCNB1_RAT Potassium voltage-gated channel subfamily
B member 1 OS=Rattus norvegicus OX=10116 GN=Kcnb1 PE=1 SV=3
Length=857
Score = 60.1 bits (144), Expect = 7e-08, Method: Composition-based stats.
Identities = 57/366 (16%), Positives = 119/366 (33%), Gaps = 32/366 (9%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + + VE +C+ F +
Sbjct 186 VAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYL 245
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K L+ + V + + L + RI R+L
Sbjct 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 305
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +DD
Sbjct 306 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDEDD----- 358
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F+++P S + +TT D+ + I ++ + L I
Sbjct 359 --TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 411
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAF-EVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
I + F + + + ++ RR RA + SM + +
Sbjct 412 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGES 471
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ D + + LS K F ++ ++ Q +Q +
Sbjct 472 IAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLED 531
Query 428 LFGHYY 433
++
Sbjct 532 MYSKMA 537
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 51/381 (13%), Positives = 119/381 (31%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G + + L + ++ L+S + +K L E
Sbjct 96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETL 155
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
++ E D + E + L+ + + + + +++ + +
Sbjct 156 REREGEEFDNTCCAEKR---KKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLP 212
Query 456 DA---DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L
Sbjct 213 ELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPKKWKFFKGPLNA 264
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 265 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 319
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 320 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDDTKFKSIPA-------- 366
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 367 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 407
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 408 PIPIIVNNFSEFYKEQKRQEK 428
>sp|Q03717|KCNB1_MOUSE Potassium voltage-gated channel subfamily
B member 1 OS=Mus musculus OX=10090 GN=Kcnb1 PE=1 SV=2
Length=857
Score = 59.7 bits (143), Expect = 8e-08, Method: Composition-based stats.
Identities = 58/366 (16%), Positives = 119/366 (33%), Gaps = 32/366 (9%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + + VE +C+ F +
Sbjct 186 VAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYL 245
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K L+ + V + + L + RI R+L
Sbjct 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 305
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +DD
Sbjct 306 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDEDD----- 358
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F+++P S + +TT D+ + I ++ + L I
Sbjct 359 --TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 411
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAF-EVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
I + F + + + ++ RR RA + SM + +
Sbjct 412 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGEG 471
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ D + + LS K F ++ ++ Q +Q Q
Sbjct 472 VAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLQD 531
Query 428 LFGHYY 433
++
Sbjct 532 MYSKMA 537
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 51/381 (13%), Positives = 119/381 (31%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G + + L + ++ L+S + +K L E
Sbjct 96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETL 155
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
++ E D + E + L+ + + + + +++ + +
Sbjct 156 REREGEEFDNTCCAEKR---KKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLP 212
Query 456 DA---DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L
Sbjct 213 ELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPKKWKFFKGPLNA 264
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 265 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 319
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 320 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDDTKFKSIPA-------- 366
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 367 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 407
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 408 PIPIIVNNFSEFYKEQKRQEK 428
>sp|Q14721|KCNB1_HUMAN Potassium voltage-gated channel subfamily
B member 1 OS=Homo sapiens OX=9606 GN=KCNB1 PE=1 SV=2
Length=858
Score = 59.7 bits (143), Expect = 9e-08, Method: Composition-based stats.
Identities = 57/366 (16%), Positives = 119/366 (33%), Gaps = 32/366 (9%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + + VE +C+ F +
Sbjct 186 VAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYL 245
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K L+ + V + + L + RI R+L
Sbjct 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 305
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +DD
Sbjct 306 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDEDD----- 358
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F+++P S + +TT D+ + I ++ + L I
Sbjct 359 --TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 411
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAF-EVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
I + F + + + ++ RR RA + SM + +
Sbjct 412 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGEN 471
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ D + + LS K F ++ ++ Q +Q +
Sbjct 472 MGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLED 531
Query 428 LFGHYY 433
++
Sbjct 532 MYNKMA 537
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 51/381 (13%), Positives = 119/381 (31%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G + + L + ++ L+S + +K L E
Sbjct 96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETL 155
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
++ E D + E + L+ + + + + +++ + +
Sbjct 156 REREGEEFDNTCCAEKR---KKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLP 212
Query 456 DA---DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L
Sbjct 213 ELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPKKWKFFKGPLNA 264
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 265 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 319
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 320 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDDTKFKSIPA-------- 366
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 367 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 407
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 408 PIPIIVNNFSEFYKEQKRQEK 428
>sp|Q4ZHA6|KCNB2_BOVIN Potassium voltage-gated channel subfamily
B member 2 OS=Bos taurus OX=9913 GN=KCNB2 PE=2 SV=1
Length=911
Score = 59.7 bits (143), Expect = 9e-08, Method: Composition-based stats.
Identities = 62/368 (17%), Positives = 125/368 (34%), Gaps = 42/368 (11%)
Query 86 LSFTIFLILFLAFIETPSSLTS-------TADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ I I+ + FI + S + P VE +C+ F
Sbjct 190 VAAKILAIVSILFIVLSTIALSLNTLPELQEMDEFGQPNDNPQLA---HVEAVCIAWFTM 246
Query 139 DLSVKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIR 187
+ ++ F K + L+ + V + + L + RI
Sbjct 247 EYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIM 306
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+LR L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +
Sbjct 307 RILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFA-------E 357
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
E T F ++P S + +TT D+ + I ++ + L
Sbjct 358 KDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALP 412
Query 308 TAIIYSQFRGYLMKSL--QTSLFRRRLGTRAAFE---VLSSMVGEGGAFPQAVGVKPQNL 362
II + F + + + ++ RR RA V ++ + + V +
Sbjct 413 IPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKT 472
Query 363 LQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
+ + D+ + + R S S + ++ + E+ + E SP
Sbjct 473 GESANTKGSTDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQKDSHEQLNNTSSSSP 532
Query 421 FLQSAQFL 428
SAQ L
Sbjct 533 QHLSAQKL 540
Score = 54.3 bits (129), Expect = 4e-06, Method: Composition-based stats.
Identities = 53/381 (14%), Positives = 121/381 (32%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G+ + + L + ++ L+S + +K L E
Sbjct 100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETM 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV- 454
++ E D + E + L+ + L + + +++ + +
Sbjct 160 REREGEEFDNTCCPEKR---KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLP 216
Query 455 --LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L V
Sbjct 217 ELQEMDEFGQPNDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPNKWKFFKGPLNV 268
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 269 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 323
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 324 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDATKFTSIPA-------- 370
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 371 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 411
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 412 PIPIIVNNFSEFYKEQKRQEK 432
>sp|P79197|KCNA5_MUSPF Potassium voltage-gated channel subfamily
A member 5 OS=Mustela putorius furo OX=9669 GN=KCNA5 PE=2
SV=1
Length=601
Score = 59.4 bits (142), Expect = 9e-08, Method: Composition-based stats.
Identities = 40/229 (17%), Positives = 86/229 (38%), Gaps = 35/229 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE C++ F +L V+ + A F +N+ + +V + + L
Sbjct 316 VETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQPGGGGGG 375
Query 177 -------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCL 229
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 376 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLIFFLF 430
Query 230 FTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYA 289
G++LF+ + + T+F ++P++ +V +TT D+ +
Sbjct 431 ---IGVILFSSAV-YFAEADNQETHFSSIPDAFWWAVVTMTTVGYGDMRPVTVGGKIVGS 486
Query 290 IFFIVFTVIGSLFLMNLLTAIIYSQFRGY---LMKSLQTSLFRRRLGTR 335
+ I + + L +I S F + + + + G++
Sbjct 487 LCAI-----AGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGSQ 530
Score = 54.3 bits (129), Expect = 3e-06, Method: Composition-based stats.
Identities = 36/253 (14%), Positives = 80/253 (32%), Gaps = 34/253 (13%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
I+ ++++ E+L++ FA + S N+ + + V+ + L
Sbjct 313 FFIVETTCVIWFTFELLVRFFACPSKAEFS--RNIMN--IIDVVAIFPYFITLGTELAEQ 368
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
+L ++ + R RI + + L +MR G ++
Sbjct 369 PGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIF- 427
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++ G+ LF + ++ + D F A+VT
Sbjct 428 FLFI----GVILFSSAVYFAEADNQETHFSSIP---------------DAFWWAVVT--- 465
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
+ V R KI ++ V+ + L + +I+ NF + + + +
Sbjct 466 MTTVG------YGDMRPVTVGGKI-VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHE 518
Query 709 PLAGTPEATYQMT 721
A E +
Sbjct 519 EQAALKEEQGSQS 531
>sp|Q95L11|KCNB2_RABIT Potassium voltage-gated channel subfamily
B member 2 OS=Oryctolagus cuniculus OX=9986 GN=KCNB2 PE=2
SV=1
Length=911
Score = 59.4 bits (142), Expect = 1e-07, Method: Composition-based stats.
Identities = 48/273 (18%), Positives = 95/273 (35%), Gaps = 37/273 (14%)
Query 86 LSFTIFLILFLAFIETPSSLTS-------TADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ I I+ + FI + S + P VE +C+ F
Sbjct 190 VAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQPSDNPKLA---HVEAVCIAWFTM 246
Query 139 DLSVKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIR 187
+ ++ F K + L+ + V + + L + RI
Sbjct 247 EYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIM 306
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+LR L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +
Sbjct 307 RILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFA-------E 357
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
E T F ++P S + +TT D+ + I ++ + L
Sbjct 358 KDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALP 412
Query 308 TAIIYSQFRGYLMKSL--QTSLFRRRLGTRAAF 338
II + F + + + ++ RR RA
Sbjct 413 IPIIVNNFSEFYKEQKRQEKAIKRREALERAKR 445
Score = 55.1 bits (131), Expect = 2e-06, Method: Composition-based stats.
Identities = 53/381 (14%), Positives = 121/381 (32%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G+ + + L + ++ L+S + +K L E
Sbjct 100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETM 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV- 454
++ E D + E + L+ + L + + +++ + +
Sbjct 160 REREGEEFDNTCCPEKR---KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLP 216
Query 455 --LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L V
Sbjct 217 ELQETDEFGQPSDNPKLAHVEAVCIAWFTMEYLLR--------FLSSPNKWKFFKGPLNV 268
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 269 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 323
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 324 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDATKFTSIPA-------- 370
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 371 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 411
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 412 PIPIIVNNFSEFYKEQKRQEK 432
>sp|Q92953|KCNB2_HUMAN Potassium voltage-gated channel subfamily
B member 2 OS=Homo sapiens OX=9606 GN=KCNB2 PE=1 SV=2
Length=911
Score = 59.4 bits (142), Expect = 1e-07, Method: Composition-based stats.
Identities = 64/365 (18%), Positives = 122/365 (33%), Gaps = 36/365 (10%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRA----APWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + VE +C+ F +
Sbjct 190 VAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYL 249
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K + L+ + V + + L + RI R+L
Sbjct 250 LRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 309
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA + E
Sbjct 310 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFA-------EKDE 360
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F ++P S + +TT D+ + I ++ + L I
Sbjct 361 DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 415
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAFEVLSSMVGEGGAFP-----QAVGVKPQNLL 363
I + F + + + ++ RR RA + AF V V+
Sbjct 416 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGES 475
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
+ D+ + + R S S + F+ + E+ + E SP
Sbjct 476 ANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHL 535
Query 424 SAQFL 428
SAQ L
Sbjct 536 SAQKL 540
Score = 53.6 bits (127), Expect = 6e-06, Method: Composition-based stats.
Identities = 52/381 (14%), Positives = 121/381 (32%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G+ + + L + ++ L+S + +K L E
Sbjct 100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETM 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV- 454
++ E D + + + L+ + L + + +++ + +
Sbjct 160 REREGEEFDNTCCPDKR---KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLP 216
Query 455 --LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L V
Sbjct 217 ELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLR--------FLSSPNKWKFFKGPLNV 268
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 269 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 323
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 324 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDATKFTSIPA-------- 370
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 371 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 411
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 412 PIPIIVNNFSEFYKEQKRQEK 432
>sp|O18868|KCNB1_PIG Potassium voltage-gated channel subfamily
B member 1 OS=Sus scrofa OX=9823 GN=KCNB1 PE=2 SV=1
Length=858
Score = 59.0 bits (141), Expect = 1e-07, Method: Composition-based stats.
Identities = 59/366 (16%), Positives = 120/366 (33%), Gaps = 32/366 (9%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + + VE +C+ F +
Sbjct 186 VAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQTTDNPQLAHVEAVCIAWFTMEYL 245
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K L+ + V + + L + RI R+L
Sbjct 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 305
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +DD
Sbjct 306 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDEDD----- 358
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F+++P S + +TT D+ + I ++ + L I
Sbjct 359 --TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 411
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAF-EVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
I + F + + + ++ RR RA + SM + + V
Sbjct 412 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFPRSIEMMDIVVEKNVEN 471
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
Q D + + LS K F ++ ++ Q +Q +
Sbjct 472 MGQKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLED 531
Query 428 LFGHYY 433
++
Sbjct 532 MYNKMA 537
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 51/381 (13%), Positives = 119/381 (31%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G + + L + ++ L+S + +K L E
Sbjct 96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETL 155
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
++ E D + E + L+ + + + + +++ + +
Sbjct 156 REREGEEFDNTCCAEKR---KKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLP 212
Query 456 DA---DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L
Sbjct 213 ELQSLDEFGQTTDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPKKWKFFKGPLNA 264
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 265 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 319
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 320 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDDTKFKSIPA-------- 366
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 367 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 407
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 408 PIPIIVNNFSEFYKEQKRQEK 428
>sp|A4K2Y2|KCNS1_CHLAE Potassium voltage-gated channel subfamily
S member 1 OS=Chlorocebus aethiops OX=9534 GN=KCNS1 PE=3
SV=1
Length=529
Score = 58.2 bits (139), Expect = 2e-07, Method: Composition-based stats.
Identities = 39/257 (15%), Positives = 92/257 (36%), Gaps = 28/257 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
S +A E + SV +E + EL R +++ +
Sbjct 162 SQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ G +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGK------ 335
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 336 -ELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 390 VSVFSGVAYTAEKEEDV 406
Score = 44.7 bits (104), Expect = 0.003, Method: Composition-based stats.
Identities = 40/239 (17%), Positives = 92/239 (38%), Gaps = 31/239 (13%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ------------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV-- 388
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
G+ +F+G ++E F +P V +TT DV+ + A
Sbjct 389 ------GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA 440
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
+ ++G + ++ L II+++F + + R + ++LSS+ G
Sbjct 441 ASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDG 494
>sp|Q9MZ19|KCNB1_RABIT Potassium voltage-gated channel subfamily
B member 1 OS=Oryctolagus cuniculus OX=9986 GN=KCNB1 PE=2
SV=1
Length=858
Score = 58.6 bits (140), Expect = 2e-07, Method: Composition-based stats.
Identities = 56/366 (15%), Positives = 119/366 (33%), Gaps = 32/366 (9%)
Query 86 LSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGLTESVEVLCLLVFAADLS 141
++ I I+ + FI + S + + VE +C+ F +
Sbjct 186 VAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQTTDNPQLAHVEAVCIAWFTMEYL 245
Query 142 VKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLL 190
++ F K L+ + V + + L + RI R+L
Sbjct 246 LRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRIL 305
Query 191 RPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRE 250
R L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +DD
Sbjct 306 RILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDEDD----- 358
Query 251 RLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAI 310
T F+++P S + +TT D+ + I ++ + L I
Sbjct 359 --TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALPIPI 411
Query 311 IYSQFRGYLMKSL--QTSLFRRRLGTRAAF-EVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
I + F + + + ++ RR RA + SM + +
Sbjct 412 IVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSVEMMDIVVEKNGEN 471
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQF 427
+ + + + LS K F ++ ++ Q +Q +
Sbjct 472 LAKKEKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLED 531
Query 428 LFGHYY 433
++
Sbjct 532 MYNKMA 537
Score = 51.3 bits (121), Expect = 3e-05, Method: Composition-based stats.
Identities = 51/381 (13%), Positives = 119/381 (31%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G + + L + ++ L+S + +K L E
Sbjct 96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETL 155
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
++ E D + E + L+ + + + + +++ + +
Sbjct 156 REREGEEFDNTCCAEKR---KKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLP 212
Query 456 DA---DVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L
Sbjct 213 ELQSLDEFGQTTDNPQLAHVEAVCIAWFTMEYLLR--------FLSSPKKWKFFKGPLNA 264
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 265 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 319
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 320 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDDTKFKSIPA-------- 366
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 367 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 407
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 408 PIPIIVNNFSEFYKEQKRQEK 428
>sp|A4K2T1|KCNS1_MACMU Potassium voltage-gated channel subfamily
S member 1 OS=Macaca mulatta OX=9544 GN=KCNS1 PE=3 SV=1
Length=529
Score = 58.2 bits (139), Expect = 2e-07, Method: Composition-based stats.
Identities = 38/257 (15%), Positives = 92/257 (36%), Gaps = 28/257 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 162 TQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ G +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGK------ 335
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 336 -ELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 390 VSVFSGVAYTAEKEEDV 406
Score = 44.7 bits (104), Expect = 0.003, Method: Composition-based stats.
Identities = 40/239 (17%), Positives = 92/239 (38%), Gaps = 31/239 (13%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ------------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV-- 388
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
G+ +F+G ++E F +P V +TT DV+ + A
Sbjct 389 ------GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA 440
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
+ ++G + ++ L II+++F + + R + ++LSS+ G
Sbjct 441 ASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDG 494
>sp|A4K2M4|KCNS1_PAPAN Potassium voltage-gated channel subfamily
S member 1 OS=Papio anubis OX=9555 GN=KCNS1 PE=3 SV=1
Length=529
Score = 57.8 bits (138), Expect = 2e-07, Method: Composition-based stats.
Identities = 38/257 (15%), Positives = 92/257 (36%), Gaps = 28/257 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 162 TQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ G +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGK------ 335
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 336 -ELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 390 VSVFSGVAYTAEKEEDV 406
Score = 43.9 bits (102), Expect = 0.006, Method: Composition-based stats.
Identities = 39/237 (16%), Positives = 91/237 (38%), Gaps = 31/237 (13%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ------------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV-- 388
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
G+ +F+G ++E F +P V +TT DV+ + A
Sbjct 389 ------GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA 440
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
+ ++G + ++ L II+++F + + R + ++LSS+
Sbjct 441 ASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSV 492
>sp|P59994|KCND1_RABIT A-type voltage-gated potassium channel
KCND1 OS=Oryctolagus cuniculus OX=9986 GN=KCND1 PE=2 SV=2
Length=647
Score = 58.2 bits (139), Expect = 2e-07, Method: Composition-based stats.
Identities = 49/309 (16%), Positives = 108/309 (35%), Gaps = 31/309 (10%)
Query 69 SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVR----YRAAPWEPPCGL 124
SS+ + + +F + FI + R P E PCG
Sbjct 166 SSIRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGPARRPPREQPCGD 225
Query 125 -----TESVEVLCLLVFAADLSVKGYLFGWA-HFQKNLWLLGYLVVLV---VSLVDWTVS 175
++ C+L+F + ++ + F +++ L +V ++ + L+
Sbjct 226 RFPLAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNE 285
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
LR+ R+ R F ++S ++ ++ E+ + L + + +F +
Sbjct 286 DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--V 343
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVF 295
+ +A + T F ++P + +V +TT D M+P A IF +
Sbjct 344 MFYA-------EKGTSKTNFTSIPAAFWYTIVTMTTLGYGD-MVP---STIAGKIFGSIC 392
Query 296 TVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAV 355
++ G L + L +I S F + + + + + + + G +
Sbjct 393 SLSGVLVIA-LPVPVIVSNFS----RIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFL 447
Query 356 GVKPQNLLQ 364
K L+
Sbjct 448 QYKQNGGLE 456
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 49/391 (13%), Positives = 108/391 (28%), Gaps = 74/391 (19%)
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
E + + E + + L+ + + +++ + A E+ G
Sbjct 106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAQRLAEDEEAEQTGDG------ 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL-- 453
+ + ++ F Y+ ++++ V
Sbjct 160 ----------PALPAGSSIRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP 209
Query 454 ----VLDADVLPAERDDFILGIL--NCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
D F L + ++ + E LL++FA PS L
Sbjct 210 CRGPARRPPREQPCGDRFPLAFFCMDTACVLIFTGEYLLRLFA--------APSRC-RFL 260
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+V+ L+ ++ L Y ++ G L + VFR + + + +
Sbjct 261 RSVMSLIDVVAILPYYIGLLVPKNEDVSG------AFVTLRVFRVFRIFKFSRHSQGLRI 314
Query 568 VASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
+ T+ + L + +FA + +F +
Sbjct 315 LGYTLKSCASELGFLLFSLTMAIIIFATV---MF------------------------YA 347
Query 628 QLEYWANNFDDFAAAL-VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV 686
+ NF AA T+ + + S KI F +S V+ +
Sbjct 348 EKGTSKTNFTSIPAAFWYTIVTMTTLG------YGDMVPSTIAGKI-FGSICSLSGVLVI 400
Query 687 NLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
L + +I+ NF + +
Sbjct 401 ALPVPVIVSNFSRIYHQNQRADKRRAQQKVR 431
>sp|A4K2P6|KCNS1_COLGU Potassium voltage-gated channel subfamily
S member 1 OS=Colobus guereza OX=33548 GN=KCNS1 PE=3 SV=1
Length=529
Score = 57.8 bits (138), Expect = 3e-07, Method: Composition-based stats.
Identities = 38/257 (15%), Positives = 92/257 (36%), Gaps = 28/257 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 162 TQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ G +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGK------ 335
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 336 -ELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 390 VSVFSGVAYTAEKEEDV 406
Score = 43.6 bits (101), Expect = 0.007, Method: Composition-based stats.
Identities = 39/237 (16%), Positives = 91/237 (38%), Gaps = 31/237 (13%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ------------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV-- 388
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
G+ +F+G ++E F +P V +TT DV+ + A
Sbjct 389 ------GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLA 440
Query 288 YAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
+ ++G + ++ L II+++F + + R + ++LSS+
Sbjct 441 ASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSV 492
>sp|Q63099|KCNB2_RAT Potassium voltage-gated channel subfamily
B member 2 OS=Rattus norvegicus OX=10116 GN=Kcnb2 PE=1 SV=2
Length=907
Score = 57.8 bits (138), Expect = 3e-07, Method: Composition-based stats.
Identities = 61/368 (17%), Positives = 127/368 (35%), Gaps = 42/368 (11%)
Query 86 LSFTIFLILFLAFIETPSSLTS-------TADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ I I+ + FI + S + + VE +C+ F
Sbjct 190 VAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLA---HVEAVCIAWFTM 246
Query 139 DLSVKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIR 187
+ ++ F K + L+ + V + + L + RI
Sbjct 247 EYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIM 306
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+LR L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +
Sbjct 307 RILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFA-------E 357
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
E T F ++P S + +TT D+ + I ++ + L
Sbjct 358 KDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALP 412
Query 308 TAIIYSQFRGYLMKSL--QTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQV 365
II + F + + + ++ RR RA + AF +++ + + +
Sbjct 413 IPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKA 472
Query 366 LQKVQL-----DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP 420
+ + D+ + + R S S + ++ + E+ + E SP
Sbjct 473 GESANIKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQKDSHEQLNNTSSSSP 532
Query 421 FLQSAQFL 428
SAQ L
Sbjct 533 QHLSAQKL 540
Score = 54.0 bits (128), Expect = 5e-06, Method: Composition-based stats.
Identities = 49/338 (14%), Positives = 106/338 (31%), Gaps = 58/338 (17%)
Query 385 SYGSVLLSAEEFQKLFNELDRSVVKEH------PPRPEYQSPFLQSAQFLFGHYYFDYLG 438
Y E + E R E P + + L+ +
Sbjct 140 RYHQKKEQMNEELRREAETMRDGEGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVS 199
Query 439 NLIALANLVSICVFLV---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
L + + +++ + + + D D+ L + V I ++ +E LL+
Sbjct 200 ILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLR-------- 251
Query 496 YLSYP--SNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
+LS P F G L V+ L+ + L +L ++ R++ + +
Sbjct 252 FLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIM 306
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
R LRI+ + + S L ++ G +++ F +GI +F ++ +
Sbjct 307 RILRILKLARHSTGLQSLGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDED 361
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIY 673
F A +T M + P + +
Sbjct 362 ATKFTSIPA---------------SFWWATIT----MTTVGYGDIY--------PKTLLG 394
Query 674 FVLWWLVSS--VIWVNLFLALILENFLHKWDPRSHLQP 709
++ L V+ + L + +I+ NF + + +
Sbjct 395 KIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 432
>sp|P50638|KCNA5_RABIT Potassium voltage-gated channel subfamily
A member 5 OS=Oryctolagus cuniculus OX=9986 GN=KCNA5 PE=2
SV=1
Length=598
Score = 57.4 bits (137), Expect = 3e-07, Method: Composition-based stats.
Identities = 40/230 (17%), Positives = 86/230 (37%), Gaps = 36/230 (16%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE C++ F +L V+ + A F +N+ + +V + + L
Sbjct 312 VETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGGGGG 371
Query 177 --------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 372 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLIFFL 426
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
G++LF+ + + T+F ++P++ +V +TT D+
Sbjct 427 F---IGVILFSSAV-YFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVG 482
Query 289 AIFFIVFTVIGSLFLMNLLTAIIYSQFRGY---LMKSLQTSLFRRRLGTR 335
++ I + + L +I S F + + + + G++
Sbjct 483 SLCAI-----AGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEPGSQ 527
Score = 52.8 bits (125), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/256 (15%), Positives = 84/256 (33%), Gaps = 35/256 (14%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYL-SYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
I+ ++++ E+L++ FA + N+ D + + + LA +
Sbjct 309 FFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGG 368
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
G +SL +L ++ + R RI + + L +MR G ++
Sbjct 369 GGGGQNGQQAMSLA----ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIF 424
Query 588 VVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLW 647
++ G+ LF + ++ + D F A+VT
Sbjct 425 -FLFI----GVILFSSAVYFAEADNQGTHFSSIP---------------DAFWWAVVT-- 462
Query 648 NLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHL 707
+ V R KI ++ V+ + L + +I+ NF + + +
Sbjct 463 -MTTVG------YGDMRPITVGGKI-VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDH 514
Query 708 QPLAGTPEATYQMTVE 723
+ A E +
Sbjct 515 EEQAALKEEPGSQSRG 530
>sp|A4K2Q6|KCNS1_OTOGA Potassium voltage-gated channel subfamily
S member 1 OS=Otolemur garnettii OX=30611 GN=KCNS1 PE=3 SV=1
Length=528
Score = 57.0 bits (136), Expect = 4e-07, Method: Composition-based stats.
Identities = 39/254 (15%), Positives = 89/254 (35%), Gaps = 27/254 (11%)
Query 376 KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
+A E + SV +E + EL R +++ + F
Sbjct 164 PRAWDEDSDTPSSVDPCTDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFS 223
Query 436 YLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIVYY 480
+ + LA++ ++C+ + + RDD +L L I ++
Sbjct 224 CVSIGVVLASIAAMCIHSLPEYQAHEAAAAVATVVAGRGAEGVRDDPVLRRLEYFCIAWF 283
Query 481 LLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
E+ ++ A R + +P N+ D + + + ++ +A+ G G
Sbjct 284 SFEVSSRLLLAPSARNFFCHPLNLIDIVSVLPFYLTLLAGVAL------GGNQNGTGGEE 337
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
L +++ + + R R++ + + S L + R G +L+ + +G++
Sbjct 338 LGHFGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVGVS 392
Query 600 LFRGVIVALPGNSS 613
+F GV
Sbjct 393 VFSGVAYTAEKEED 406
Score = 40.9 bits (94), Expect = 0.041, Method: Composition-based stats.
Identities = 41/240 (17%), Positives = 93/240 (39%), Gaps = 32/240 (13%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC-- 180
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSARNFFCHPLNLIDIVSVLPFYLTLLAGVALGGNQ 330
Query 181 --------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 NGTGGEELGHFGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV- 389
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
G+ +F+G ++ + F +P V +TT DV+ +
Sbjct 390 -------GVSVFSGVAYTAEKEEDEG--FATIPACWWWGTVSMTTVGYGDVVPVTLAGKL 440
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
A + ++G + ++ L II+++F + + R G R ++LSS+ G
Sbjct 441 AASG-----CILGGILVVALPITIIFNKFSHFYQRQKALEAAVRNSGHREFEDLLSSIDG 495
>sp|P22001|KCNA3_HUMAN Potassium voltage-gated channel subfamily
A member 3 OS=Homo sapiens OX=9606 GN=KCNA3 PE=1 SV=3
Length=575
Score = 57.4 bits (137), Expect = 4e-07, Method: Composition-based stats.
Identities = 34/161 (21%), Positives = 70/161 (43%), Gaps = 21/161 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ +L V+ + A F +N+ L +V ++ + L
Sbjct 298 VETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQA 357
Query 177 -SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G+
Sbjct 358 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IGV 409
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
+LF+ + + + F ++P++ +V +TT D
Sbjct 410 ILFSSAV-YFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGD 449
Score = 48.2 bits (113), Expect = 3e-04, Method: Composition-based stats.
Identities = 38/273 (14%), Positives = 86/273 (32%), Gaps = 49/273 (18%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
V +D ++ ++ +E E PR ++Q +
Sbjct 173 VNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEE-------RPLPRRDFQRQVWLLFE 225
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI------------------ 468
+ + + L L+SI +F + E+D
Sbjct 226 YPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSR 285
Query 469 ---------LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
++ + I+++ E+L++ FA + S N+ + L+ +V ++ T
Sbjct 286 AGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFS--RNIMN-LIDIVAIIPYFIT 342
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
L G + + L +L ++ + R RI + + L +M
Sbjct 343 LGTELAERQGNGQQAMSLA-------ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 395
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R G ++ ++ G+ LF + +
Sbjct 396 RELGLLIF-FLFI----GVILFSSAVYFAEADD 423
>sp|P22460|KCNA5_HUMAN Potassium voltage-gated channel subfamily
A member 5 OS=Homo sapiens OX=9606 GN=KCNA5 PE=1 SV=4
Length=613
Score = 57.0 bits (136), Expect = 4e-07, Method: Composition-based stats.
Identities = 41/234 (18%), Positives = 88/234 (38%), Gaps = 36/234 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE C++ F +L V+ + A F +N+ + +V + + L
Sbjct 327 VETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGG 386
Query 177 --------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 387 GQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLIFFL 441
Query 229 LFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
G++LF+ + + T+F ++P++ +V +TT D+
Sbjct 442 F---IGVILFSSAV-YFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVG 497
Query 289 AIFFIVFTVIGSLFLMNLLTAIIYSQFRGY---LMKSLQTSLFRRRLGTRAAFE 339
++ I + + L +I S F + + ++ + GT++
Sbjct 498 SLCAI-----AGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGP 546
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 23/146 (16%), Positives = 53/146 (36%), Gaps = 10/146 (7%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYL-SYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
I+ ++++ E+L++ FA + N+ D + + + LA +
Sbjct 324 FFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGG 383
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
G +SL +L ++ + R RI + + L +MR G ++
Sbjct 384 GGGGQNGQQAMSLA----ILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIF 439
Query 588 VVYYVFAIIGINLFRGVIVALPGNSS 613
++ G+ LF + ++
Sbjct 440 -FLFI----GVILFSSAVYFAEADNQ 460
>sp|Q52PG9|KCND1_BOVIN A-type voltage-gated potassium channel
KCND1 OS=Bos taurus OX=9913 GN=KCND1 PE=2 SV=1
Length=648
Score = 57.0 bits (136), Expect = 5e-07, Method: Composition-based stats.
Identities = 49/309 (16%), Positives = 108/309 (35%), Gaps = 31/309 (10%)
Query 69 SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAA----PWEPPCGL 124
SS+ + + +F + FI + R+ P E PCG
Sbjct 166 SSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRSPTRRPPREQPCGD 225
Query 125 -----TESVEVLCLLVFAADLSVKGYLFGWA-HFQKNLWLLGYLVVLV---VSLVDWTVS 175
++ C+L+F + ++ + F +++ L +V ++ + L
Sbjct 226 RFPLAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFMPKNE 285
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
LR+ R+ R F ++S ++ ++ E+ + L + + +F +
Sbjct 286 DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--V 343
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVF 295
+ +A + T F ++P + +V +TT D M+P A IF +
Sbjct 344 MFYA-------EKGTNKTNFTSIPAAFWYTIVTMTTLGYGD-MVP---STIAGKIFGSIC 392
Query 296 TVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAV 355
++ G L + L +I S F + + + + + + + G +
Sbjct 393 SLSGVLVIA-LPVPVIVSNFS----RIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFL 447
Query 356 GVKPQNLLQ 364
K L+
Sbjct 448 QYKQNGSLE 456
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 47/387 (12%), Positives = 101/387 (26%), Gaps = 59/387 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
+ G Q L + + + E E ++
Sbjct 95 LNFYRTGRLHCPRQECIQAFDEEL-AFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEA 153
Query 400 FNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF-LVLDAD 458
D + + ++ F Y+ ++++ V + +
Sbjct 154 EQAGDGPTLPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRSP 213
Query 459 VLPAERDDFILGILNCVF-------IVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
R+ F ++ + E LL++FA PS L +V+
Sbjct 214 TRRPPREQPCGDRFPLAFFCMDTACVLIFTGEYLLRLFA--------APSRC-RFLRSVM 264
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
L+ ++ L M + L + VFR + + + ++ T
Sbjct 265 SLIDVVAIL------PYYIGLFMPKNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 318
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
+ + L + +FA + +F + +
Sbjct 319 LKSCASELGFLLFSLTMAIIIFATV---MF------------------------YAEKGT 351
Query 632 WANNFDDFAAAL-VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFL 690
NF AA T+ + + S KI F +S V+ + L +
Sbjct 352 NKTNFTSIPAAFWYTIVTMTTLG------YGDMVPSTIAGKI-FGSICSLSGVLVIALPV 404
Query 691 ALILENFLHKWDPRSHLQPLAGTPEAT 717
+I+ NF + +
Sbjct 405 PVIVSNFSRIYHQNQRADKRRAQQKVR 431
>sp|A6H8H5|KCNB2_MOUSE Potassium voltage-gated channel subfamily
B member 2 OS=Mus musculus OX=10090 GN=Kcnb2 PE=1 SV=2
Length=907
Score = 57.0 bits (136), Expect = 5e-07, Method: Composition-based stats.
Identities = 47/273 (17%), Positives = 95/273 (35%), Gaps = 37/273 (14%)
Query 86 LSFTIFLILFLAFIETPSSLTS-------TADVRYRAAPWEPPCGLTESVEVLCLLVFAA 138
++ I I+ + FI + S + + VE +C+ F
Sbjct 190 VAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLA---HVEAVCIAWFTM 246
Query 139 DLSVKGYLF-GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIR 187
+ ++ F K + L+ + V + + L + RI
Sbjct 247 EYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIM 306
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+LR L ++S+ ++ +R S E+ + L LA+ + +F+ + FA +
Sbjct 307 RILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFA-------E 357
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
E T F ++P S + +TT D+ + I ++ + L
Sbjct 358 KDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV-----IALP 412
Query 308 TAIIYSQFRGYLMKSL--QTSLFRRRLGTRAAF 338
II + F + + + ++ RR RA
Sbjct 413 IPIIVNNFSEFYKEQKRQEKAIKRREALERAKR 445
Score = 54.7 bits (130), Expect = 3e-06, Method: Composition-based stats.
Identities = 53/381 (14%), Positives = 121/381 (32%), Gaps = 59/381 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEE-- 395
+ G+ + + L + ++ L+S + +K L E
Sbjct 100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETM 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV- 454
++ E D + E + L+ + L + + +++ + +
Sbjct 160 REREGEEFDNTCCPEKR---KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLP 216
Query 455 --LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTV 510
+ D D+ L + V I ++ +E LL+ +LS P F G L V
Sbjct 217 ELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLR--------FLSSPNKWKFFKGPLNV 268
Query 511 VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAS 570
+ L+ + L +L ++ R++ + + R LRI+ + + S
Sbjct 269 IDLLAILPYYVTIFLTESNKS-----VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQS 323
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
L ++ G +++ F +GI +F ++ +
Sbjct 324 LGFTLRRSYNELGLLIL-----FLAMGIMIFSSLVFFAEKDEDATKFTSIPA-------- 370
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSS--VIWVNL 688
F A +T M + P + + ++ L V+ + L
Sbjct 371 -------SFWWATIT----MTTVGYGDIY--------PKTLLGKIVGGLCCIAGVLVIAL 411
Query 689 FLALILENFLHKWDPRSHLQP 709
+ +I+ NF + + +
Sbjct 412 PIPIIVNNFSEFYKEQKRQEK 432
>sp|Q61762|KCNA5_MOUSE Potassium voltage-gated channel subfamily
A member 5 OS=Mus musculus OX=10090 GN=Kcna5 PE=1 SV=2
Length=602
Score = 56.7 bits (135), Expect = 6e-07, Method: Composition-based stats.
Identities = 39/228 (17%), Positives = 85/228 (37%), Gaps = 34/228 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE C++ F +L V+ + A F +N+ + +V + + L
Sbjct 318 VETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGGGGQ 377
Query 177 ------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 378 NGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLIFFLF- 431
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G++LF+ + + ++F ++P++ +V +TT D+ ++
Sbjct 432 --IGVILFSSAV-YFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSL 488
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGY---LMKSLQTSLFRRRLGTR 335
I + + L +I S F + + + + G +
Sbjct 489 CAI-----AGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGIQ 531
Score = 51.6 bits (122), Expect = 2e-05, Method: Composition-based stats.
Identities = 39/255 (15%), Positives = 93/255 (36%), Gaps = 35/255 (14%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
I+ ++++ E+L++ FA + S N+ + + V + I+ P
Sbjct 315 FFIVETTCVIWFTFELLVRFFACPSKAEFS--RNIMNIIDIVAIFPYFITLGTELAEQQP 372
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G + + R++ ++ VFR ++ K + ++ T+ ++ + ++
Sbjct 373 GGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG------LL 426
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++++F IG+ LF + ++ + + D F A+VT
Sbjct 427 IFFLF--IGVILFSSAVYFAEADNQGSHFSSIP---------------DAFWWAVVT--- 466
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
+ V R KI ++ V+ + L + +I+ NF + + + +
Sbjct 467 MTTVG------YGDMRPITVGGKI-VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHE 519
Query 709 PLAGTPEATYQMTVE 723
A E E
Sbjct 520 EQAALKEEQGIQRRE 534
>sp|P08510|KCNAS_DROME Potassium voltage-gated channel protein
Shaker OS=Drosophila melanogaster OX=7227 GN=Sh PE=1 SV=3
Length=655
Score = 56.7 bits (135), Expect = 7e-07, Method: Composition-based stats.
Identities = 62/395 (16%), Positives = 130/395 (33%), Gaps = 59/395 (15%)
Query 334 TRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSA 393
+R +F+ + GG + V V ++++ QA+ + G
Sbjct 145 SRPSFDAILYYYQSGGRLRRPVNVPLDVFS---EEIKFYELGDQAINKFREDEG---FIK 198
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALAN-------- 445
EE + L + + V PE Q+A+ + F L +++
Sbjct 199 EEERPLPDNEKQRKVWLLFEYPESS----QAARVVAIISVFVILLSIVIFCLETLPEFKH 254
Query 446 ---LVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYL-SYPS 501
+ ++ D +P D F L + + I+++ E+ ++ A +
Sbjct 255 YKVFNTTTNGTKIEEDEVPDITDPFFL--IETLCIIWFTFELTVRFLACPNKLNFCRDVM 312
Query 502 NVFDGLLTVVLLVLEISTLA----VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
NV D + + + + +A LP P+ + +L ++ + R R
Sbjct 313 NVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQD-KSSNQAMSLAILRVIRLVRVFR 371
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
I + + L +MR G ++ ++ IG+ LF + S +
Sbjct 372 IFKLSRHSKGLQILGRTLKASMRELGLLIFFLF-----IGVVLFSSAVYFAEAGSENSFF 426
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLW 677
D F A+VT + V G W KI
Sbjct 427 KSIP---------------DAFWWAVVT---MTTVG------YGDMTPVGVWGKI-VGSL 461
Query 678 WLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAG 712
++ V+ + L + +I+ NF + + + + +
Sbjct 462 CAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQS 496
Score = 52.8 bits (125), Expect = 9e-06, Method: Composition-based stats.
Identities = 33/215 (15%), Positives = 81/215 (38%), Gaps = 40/215 (19%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVS----------- 175
+E LC++ F +L+V+ +F +++ + ++ ++ +
Sbjct 282 IETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLP 341
Query 176 --------------LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGL 221
+SL +R+ R+ R F L ++S ++ + ++ S+ E+
Sbjct 342 KAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELG---- 397
Query 222 LLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
L I G++LF+ + ++F+++P++ +V +TT D+
Sbjct 398 -LLIFFLF---IGVVLFSSAV-YFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVG 452
Query 282 YSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ I + + L +I S F
Sbjct 453 VWGKIVGSLCAI-----AGVLTIALPVPVIVSNFN 482
>sp|P48994|TRPL_DROME Transient-receptor-potential-like protein
OS=Drosophila melanogaster OX=7227 GN=trpl PE=1 SV=2
Length=1124
Score = 56.7 bits (135), Expect = 8e-07, Method: Composition-based stats.
Identities = 42/306 (14%), Positives = 109/306 (36%), Gaps = 34/306 (11%)
Query 414 RPEYQSPFLQSAQFLFGHYYF----DYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
R + + ++ +LF + + + + + ++ + L
Sbjct 371 RKPFMKFLIHASSYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKL 430
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLT--VVLLVLEISTLAVYRLPH 527
++ ++++ ++ E + ++FA+G++ YL N D L V ++ + + +
Sbjct 431 ELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATE 490
Query 528 PGWRPEMVGLLSL-----------WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLV 576
P+M + + N+ + + + + + ++ +V
Sbjct 491 IARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMV 550
Query 577 QNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNF 636
++ F I +V + FA G+N AL + G A GS F
Sbjct 551 IDIVKFFFIYTLVLFAFAC-GLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRRF 609
Query 637 DDFAAALVTLWNLMVVNNWQVF---------LDAYRRYSGPWSKIYFVLWWLVSSVIWVN 687
+ + +L+ W F L + Y+ W + F + +++ ++ +N
Sbjct 610 GNLFESSQSLF-------WASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLN 662
Query 688 LFLALI 693
L +A++
Sbjct 663 LLIAMM 668
Score = 34.3 bits (77), Expect = 5.2, Method: Composition-based stats.
Identities = 41/340 (12%), Positives = 95/340 (28%), Gaps = 57/340 (17%)
Query 125 TESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLV-----VLVVSLVDWTVS---- 175
E + V+ ++ F + + + G + +N+W + V V+ L +
Sbjct 430 LELIVVMYVIGFVWEEVQEIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQAT 489
Query 176 -----------------------LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWS 212
++ + L+ L + + +
Sbjct 490 EIARDPQMAYIPREKWHDFDPQLIAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRM 549
Query 213 LPEMASVGLLLAIHLCLFTMFGML----LFAGGKQDDG--------------QDRERLTY 254
+ ++ + + L F G+ FA ++ +
Sbjct 550 VIDIVKFFFIYTLVLFAFAC-GLNQLLWYFAALEKSKCYVLPGGEADWGSHGDSCMKWRR 608
Query 255 FQNLPESLTSLL---VLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAII 311
F NL ES SL + ++ ++ + F ++VI + L+NLL A++
Sbjct 609 FGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMM 668
Query 312 YSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQL 371
+ + S F R + FE +++ P V +
Sbjct 669 SNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVIRIF---RKSSKTI 725
Query 372 DSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEH 411
D + E+ + + + + R
Sbjct 726 DRQRSKKRKEQEQFSEYDNIMRSLVWRYVAAMHRKFENNP 765
>sp|A4K2R3|KCNS1_GORGO Potassium voltage-gated channel subfamily
S member 1 OS=Gorilla gorilla gorilla OX=9595 GN=KCNS1 PE=3
SV=1
Length=526
Score = 56.3 bits (134), Expect = 8e-07, Method: Composition-based stats.
Identities = 36/257 (14%), Positives = 89/257 (35%), Gaps = 31/257 (12%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ A E + SV +E + EL R +++ +
Sbjct 162 TQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGH----- 336
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 337 -----LGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 386
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 387 VSVFSGVAYTAEKEEDV 403
Score = 43.9 bits (102), Expect = 0.005, Method: Composition-based stats.
Identities = 41/236 (17%), Positives = 92/236 (39%), Gaps = 28/236 (12%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ---------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV----- 385
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G+ +F+G ++E F +P V +TT DV+ + A +
Sbjct 386 ---GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
++G + ++ L II+++F + + R R ++LSS+ G
Sbjct 441 -----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHREFEDLLSSVDG 491
>sp|P19024|KCNA5_RAT Potassium voltage-gated channel subfamily
A member 5 OS=Rattus norvegicus OX=10116 GN=Kcna5 PE=1 SV=1
Length=602
Score = 56.3 bits (134), Expect = 9e-07, Method: Composition-based stats.
Identities = 40/228 (18%), Positives = 84/228 (37%), Gaps = 34/228 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE C++ F +L V+ + A F +N+ + +V + + L
Sbjct 318 VETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQ 377
Query 177 ------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 378 NGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLIFFLF- 431
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G++LF+ D ++F ++P++ +V +TT D+ ++
Sbjct 432 --IGVILFSSAVYFAEADNHG-SHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSL 488
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGY---LMKSLQTSLFRRRLGTR 335
I + + L +I S F + + + + G +
Sbjct 489 CAI-----AGVLTIALPVPVIVSNFNYFYHRETDHEEQAALKEEQGNQ 531
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 39/255 (15%), Positives = 93/255 (36%), Gaps = 35/255 (14%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
I+ ++++ E+L++ FA + S N+ + + V + I+ P
Sbjct 315 FFIVETTCVIWFTFELLVRFFACPSKAEFS--RNIMNIIDVVAIFPYFITLGTELAEQQP 372
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVV 588
G + + R++ ++ VFR ++ K + ++ T+ ++ + ++
Sbjct 373 GGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG------LL 426
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
++++F IG+ LF + ++ + + D F A+VT
Sbjct 427 IFFLF--IGVILFSSAVYFAEADNHGSHFSSIP---------------DAFWWAVVT--- 466
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQ 708
+ V R KI ++ V+ + L + +I+ NF + + + +
Sbjct 467 MTTVG------YGDMRPITVGGKI-VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHE 519
Query 709 PLAGTPEATYQMTVE 723
A E E
Sbjct 520 EQAALKEEQGNQRRE 534
>sp|Q96KK3|KCNS1_HUMAN Potassium voltage-gated channel subfamily
S member 1 OS=Homo sapiens OX=9606 GN=KCNS1 PE=1 SV=2
Length=526
Score = 55.9 bits (133), Expect = 9e-07, Method: Composition-based stats.
Identities = 36/257 (14%), Positives = 89/257 (35%), Gaps = 31/257 (12%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ A E + SV +E + EL R +++ +
Sbjct 162 TQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGH----- 336
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 337 -----LGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 386
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 387 VSVFSGVAYTAEKEEDV 403
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 40/236 (17%), Positives = 92/236 (39%), Gaps = 28/236 (12%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ---------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV----- 385
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G+ +F+G ++E F +P V +TT DV+ + A +
Sbjct 386 ---GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
++G + ++ L II+++F + + R + ++LSS+ G
Sbjct 441 -----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDG 491
>sp|A4K2N8|KCNS1_PANTR Potassium voltage-gated channel subfamily
S member 1 OS=Pan troglodytes OX=9598 GN=KCNS1 PE=3 SV=1
Length=526
Score = 55.9 bits (133), Expect = 9e-07, Method: Composition-based stats.
Identities = 36/257 (14%), Positives = 89/257 (35%), Gaps = 31/257 (12%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ A E + SV +E + EL R +++ +
Sbjct 162 TQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGH----- 336
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 337 -----LGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 386
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 387 VSVFSGVAYTAEKEEDV 403
Score = 43.9 bits (102), Expect = 0.006, Method: Composition-based stats.
Identities = 41/236 (17%), Positives = 92/236 (39%), Gaps = 28/236 (12%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ---------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV----- 385
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G+ +F+G ++E F +P V +TT DV+ + A +
Sbjct 386 ---GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
++G + ++ L II+++F + + R R ++LSS+ G
Sbjct 441 -----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHREFEDLLSSVDG 491
>sp|A4K2V2|KCNS1_PONAB Potassium voltage-gated channel subfamily
S member 1 OS=Pongo abelii OX=9601 GN=KCNS1 PE=3 SV=1
Length=526
Score = 55.9 bits (133), Expect = 9e-07, Method: Composition-based stats.
Identities = 36/257 (14%), Positives = 89/257 (35%), Gaps = 31/257 (12%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ A E + SV +E + EL R +++ +
Sbjct 162 TQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDAD---------------VLPAERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ +A+ +
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGH----- 336
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 337 -----LGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 386
Query 598 INLFRGVIVALPGNSSL 614
+++F GV +
Sbjct 387 VSVFSGVAYTAEKEEDV 403
Score = 43.9 bits (102), Expect = 0.006, Method: Composition-based stats.
Identities = 41/236 (17%), Positives = 92/236 (39%), Gaps = 28/236 (12%)
Query 124 LTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLV--- 179
+ +E C+ F+ ++S + +F + L +V ++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQG 330
Query 180 ---------CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA+
Sbjct 331 GKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAV----- 385
Query 231 TMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI 290
G+ +F+G ++E F +P V +TT DV+ + A +
Sbjct 386 ---GVSVFSGVAYT--AEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASG 440
Query 291 FFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVG 346
++G + ++ L II+++F + + R R ++LSS+ G
Sbjct 441 -----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHREFEDLLSSVDG 491
>sp|Q4GZT3|PKD2_BOVIN Polycystin-2 OS=Bos taurus OX=9913 GN=PKD2
PE=2 SV=1
Length=970
Score = 56.3 bits (134), Expect = 1e-06, Method: Composition-based stats.
Identities = 39/287 (14%), Positives = 103/287 (36%), Gaps = 44/287 (15%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE------------I 517
I+ C+FI+YY++E +L++ L Y N D ++ V+ +V +
Sbjct 479 EIIFCLFILYYVVEEILEIRIHKL-HYFRSFWNCLDVVIIVLSVVAIGINIYRTSNVEAL 537
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ P + ++ ++ + + + I + M+ +++T+ +
Sbjct 538 LQFLEDQNTFPNFENLAYWQTQFNNIAAVIVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 597
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
++ F + +++ +A + +F ++F
Sbjct 598 DLFGFAIMFFIIFLAYAQLAYLVFG----------------------------TQVDDFS 629
Query 638 DFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
F + T + +++ + + IYF + I +N+FLA+I + +
Sbjct 630 TFQECIFTQFRIILG---DINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTY 686
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ + + + + L + L++ D+++E L Q
Sbjct 687 SEVKSDLAQQKAEMELSDLIRKGYHKALIKLKLKKNTVDDISESLRQ 733
Score = 44.3 bits (103), Expect = 0.005, Method: Composition-based stats.
Identities = 47/341 (14%), Positives = 106/341 (31%), Gaps = 59/341 (17%)
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLL 190
L +L + + ++ H+ ++ W +V++V+S+V +++ R +
Sbjct 484 LFILYYVVEEILE-IRIHKLHYFRSFWNCLDVVIIVLSVVAIGINI-------YRTSNVE 535
Query 191 RPFFLLQ------NSSMM---KKTLKCIRWSLPEMASVGLLLAIHL-------------- 227
L+ N + + I + + V + L +
Sbjct 536 ALLQFLEDQNTFPNFENLAYWQTQFNNIAAVI--VFFVWIKLFKFINFNRTMSQLSTTMS 593
Query 228 ------CLFTMFGMLLF-AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA-NNPDVMI 279
F + ++F A + ++ F E + + ++ N ++
Sbjct 594 RCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEI-- 651
Query 280 PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT-RAAF 338
+ I+F F L+N+ AII + Q R +
Sbjct 652 -EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGY 710
Query 339 E--------VLSSMVGEGGAFPQAVGVKPQNLL-QVLQKVQLDSSHKQAMMEKVRSYGSV 389
+++ + Q G + L Q L+ + +A+ K G
Sbjct 711 HKALIKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQ 770
Query 390 LLSAEEFQKLFNELDRSVV-----KEHPPRPEYQSPFLQSA 425
L+ E Q++ ++L++ PRP F +S
Sbjct 771 ELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSL 811
>sp|Q05037|KCNA4_BOVIN Potassium voltage-gated channel subfamily
A member 4 OS=Bos taurus OX=9913 GN=KCNA4 PE=1 SV=1
Length=660
Score = 55.9 bits (133), Expect = 1e-06, Method: Composition-based stats.
Identities = 48/293 (16%), Positives = 103/293 (35%), Gaps = 35/293 (12%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE +C++ F+ + V+ + A F KN+ + +V ++ + L
Sbjct 382 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQ 441
Query 177 -----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
S +R+ R+ R F L ++S ++ +R S+ E+ L I
Sbjct 442 QQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG-----LLIFFLF-- 494
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIF 291
G++LF+ + E T+FQ++P++ +V +TT D+ ++
Sbjct 495 -IGVILFSSAV-YFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLC 552
Query 292 FIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAF 351
I + + L +I S F T+ +S
Sbjct 553 AI-----AGVLTIALPVPVIVSNFN-----YFYHRETENEEQTQLTQNAVSCPYLPSNLL 602
Query 352 PQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELD 404
+ +L + ++++ K+++ K + G S + + N
Sbjct 603 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEKCQGKGDDSETDKNNVSNAKA 655
Score = 49.7 bits (117), Expect = 1e-04, Method: Composition-based stats.
Identities = 46/305 (15%), Positives = 105/305 (34%), Gaps = 55/305 (18%)
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R +F+ + GG + V V ++V+ ++A+++ G + E
Sbjct 233 RPSFDAILYYYQSGGRLKRPVNVPFDIF---TEEVKFYQLGEEALLKFREDEG-FVREEE 288
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ NE + + PE SP A + L+ L ++V C+ +
Sbjct 289 DRALPENEFKKQIW-LLFEYPESSSPARGIA----------IVSVLVILISIVIFCLETL 337
Query 455 --------------------LDADVLPAERDDFILGILNCVFIVY-------YLLEMLLK 487
L D ++ I N F + + E +++
Sbjct 338 PEFRDDRDLIMALSTGGHGGLLNDTSAPHPENSGHTIFNDPFFIVETVCIVWFSFEFVVR 397
Query 488 VFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
FA + + N+ D +V ++ TL G + + R+
Sbjct 398 CFACPSQALFFKNIMNIID----IVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRI 453
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
+ ++ VFR ++ K + ++ T+ ++ + ++++++F IG+ LF +
Sbjct 454 IRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG------LLIFFLF--IGVILFSSAVY 505
Query 607 ALPGN 611
+
Sbjct 506 FAEAD 510
>sp|O35173|KCNS1_MOUSE Potassium voltage-gated channel subfamily
S member 1 OS=Mus musculus OX=10090 GN=Kcns1 PE=1 SV=2
Length=497
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 38/254 (15%), Positives = 89/254 (35%), Gaps = 28/254 (11%)
Query 376 KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
+A E + SV +E + EL R +++ + F
Sbjct 133 PRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFS 192
Query 436 YLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIVYY 480
+ + LA++ ++C+ + + RDD +L L I ++
Sbjct 193 CVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWF 252
Query 481 LLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLS 539
E+ ++ A R + +P N+ D + + + ++ A+
Sbjct 253 SFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGA-------SGEE 305
Query 540 LWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
L D+ +++ + + R R++ + + S L + R G +L+ + +G++
Sbjct 306 LGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVGVS 360
Query 600 LFRGVIVALPGNSS 613
+F GV +
Sbjct 361 VFSGVAYTAEEENE 374
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 44/242 (18%), Positives = 96/242 (40%), Gaps = 38/242 (16%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--- 180
+ +E C+ F+ ++S + L A +N + ++ +VS++ + ++L
Sbjct 240 VLRRLEYFCIAWFSFEVSSRLLL---APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALG 296
Query 181 ----------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA
Sbjct 297 DQRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLA 356
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
+ G+ +F+G ++ E F +P V +TT DV+
Sbjct 357 V--------GVSVFSGVAYTAEEENEG---FHTIPACWWWGTVSMTTVGYGDVVPETVGG 405
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
A + ++G + ++ L II+++F + + R G R ++LSS+
Sbjct 406 KLAASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQREFEDLLSSV 460
Query 345 VG 346
G
Sbjct 461 DG 462
>sp|P10499|KCNA1_RAT Potassium voltage-gated channel subfamily
A member 1 OS=Rattus norvegicus OX=10116 GN=Kcna1 PE=1 SV=1
Length=495
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 23/165 (14%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ +L V+ + F KN+ +V ++ + +
Sbjct 224 VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGE 283
Query 177 ---SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 284 QATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---I 335
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
G++LF+ + E ++F ++P++ +V +TT D+
Sbjct 336 GVILFSSAV-YFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMY 379
Score = 50.5 bits (119), Expect = 4e-05, Method: Composition-based stats.
Identities = 30/247 (12%), Positives = 80/247 (32%), Gaps = 22/247 (9%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ +E E P EYQ
Sbjct 102 LRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEE-------RPLPEKEYQRQVW 154
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD----------DFILGIL 472
++ + + + L+SI +F + L ++D ++
Sbjct 155 LLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTS 214
Query 473 NCVFIVYYLLEML-LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
N ++++E L + F+ L + D ++ + ++ + +
Sbjct 215 NIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIA 274
Query 532 PEMVGLLSL----WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ + R++ ++ VFR ++ K + ++ T+ ++ + L
Sbjct 275 EQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 334
Query 588 VVYYVFA 594
+ +F+
Sbjct 335 IGVILFS 341
>sp|P16388|KCNA1_MOUSE Potassium voltage-gated channel subfamily
A member 1 OS=Mus musculus OX=10090 GN=Kcna1 PE=1 SV=1
Length=495
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 23/165 (14%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ +L V+ + F KN+ +V ++ + +
Sbjct 224 VETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGE 283
Query 177 ---SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMF 233
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 284 QATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---I 335
Query 234 GMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
G++LF+ + E ++F ++P++ +V +TT D+
Sbjct 336 GVILFSSAV-YFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMY 379
Score = 50.5 bits (119), Expect = 4e-05, Method: Composition-based stats.
Identities = 30/247 (12%), Positives = 80/247 (32%), Gaps = 22/247 (9%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ +E E P EYQ
Sbjct 102 LRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEE-------RPLPEKEYQRQVW 154
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD----------DFILGIL 472
++ + + + L+SI +F + L ++D ++
Sbjct 155 LLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTS 214
Query 473 NCVFIVYYLLEML-LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
N ++++E L + F+ L + D ++ + ++ + +
Sbjct 215 NIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIA 274
Query 532 PEMVGLLSL----WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ + R++ ++ VFR ++ K + ++ T+ ++ + L
Sbjct 275 EQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 334
Query 588 VVYYVFA 594
+ +F+
Sbjct 335 IGVILFS 341
>sp|Q09470|KCNA1_HUMAN Potassium voltage-gated channel subfamily
A member 1 OS=Homo sapiens OX=9606 GN=KCNA1 PE=1 SV=2
Length=495
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 34/182 (19%), Positives = 76/182 (42%), Gaps = 26/182 (14%)
Query 111 VRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSL 169
V Y + + P + E++ C++ F+ +L V+ + F KN+ +V ++
Sbjct 210 VIYNSNIFTDPFFIVETL---CIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYF 266
Query 170 VDWTVSL-------------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEM 216
+ + SL +R+ R+ R F L ++S ++ + ++ S+ E+
Sbjct 267 ITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMREL 326
Query 217 ASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
L I G++LF+ + E ++F ++P++ +V +TT D
Sbjct 327 G-----LLIFFLF---IGVILFSSAV-YFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGD 377
Query 277 VM 278
+
Sbjct 378 MY 379
Score = 50.1 bits (118), Expect = 5e-05, Method: Composition-based stats.
Identities = 30/247 (12%), Positives = 80/247 (32%), Gaps = 22/247 (9%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ +E E P EYQ
Sbjct 102 LRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEE-------RPLPEKEYQRQVW 154
Query 423 QSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD----------DFILGIL 472
++ + + + L+SI +F + L ++D ++
Sbjct 155 LLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNS 214
Query 473 NCVFIVYYLLEML-LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
N ++++E L + F+ L + D ++ + ++ + +
Sbjct 215 NIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIA 274
Query 532 PEMVGLLSL----WDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ + R++ ++ VFR ++ K + ++ T+ ++ + L
Sbjct 275 EQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 334
Query 588 VVYYVFA 594
+ +F+
Sbjct 335 IGVILFS 341
>sp|A2A259|PK2L1_MOUSE Polycystin-2-like protein 1 OS=Mus musculus
OX=10090 GN=Pkd2l1 PE=1 SV=1
Length=760
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 46/265 (17%), Positives = 97/265 (37%), Gaps = 50/265 (19%)
Query 474 CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPE 533
CVFI YY++E +L++ LR YLS N+ D L+ ++L ++ + L +
Sbjct 360 CVFIFYYVVEEILEIHLHRLR-YLSSVWNILD-LVVILLSIVAVGFHIFRTLEVNRLMGK 417
Query 534 MVGLLSLWDMTRML--------------NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
++ + L + + I K M ++ST+ +++
Sbjct 418 LLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDI 477
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
F + +V++ +A +G LF + NF F
Sbjct 478 LGFAIMFFIVFFAYAQLGYLLFGTQVE----------------------------NFSTF 509
Query 640 AAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ T + +++ + +D R GP + + + +N+FLA+I + +
Sbjct 510 VKCIFTQFRIILGDFDYNAIDNANRILGPVYFV---TYVFFVFFVLLNMFLAIINDTYSE 566
Query 700 KWDP---RSHLQPLAGTPEATYQMT 721
+ + L+ + +Y T
Sbjct 567 VKEELAGQKDQLQLSDFLKQSYNKT 591
Score = 39.3 bits (90), Expect = 0.14, Method: Composition-based stats.
Identities = 39/345 (11%), Positives = 105/345 (30%), Gaps = 51/345 (15%)
Query 102 PSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGY 161
PS T + W+ E V + + + + ++ + ++W +
Sbjct 332 PSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILE-IHLHRLRYLSSVWNILD 390
Query 162 LVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP-------------FFLLQNSSMMKKTLKC 208
LVV+++S+V V R + R F L +
Sbjct 391 LVVILLSIVA-------VGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNA 443
Query 209 IR---------------WSLPEMASVGLLLAIHLCLFTMFGM-LLFAGGKQDDGQDRERL 252
+ ++ +++S A + F + + FA + ++
Sbjct 444 VNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQV 503
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
F + + + ++ + D + ++F+ + L+N+ AII
Sbjct 504 ENFSTFVKCIFTQFRIIL--GDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIIN 561
Query 313 SQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQ-----------AVGVKPQN 361
+ + + L + +L +++ + ++ ++
Sbjct 562 DTY-SEVKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFED 620
Query 362 LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
L+++ + A + G +L EE +++ L+
Sbjct 621 FTSTLRELGHEEHEITAAFTRFDQDGDHILDEEEQEQMRQGLEEE 665
>sp|P15384|KCNA3_RAT Potassium voltage-gated channel subfamily
A member 3 OS=Rattus norvegicus OX=10116 GN=Kcna3 PE=1 SV=2
Length=525
Score = 55.5 bits (132), Expect = 1e-06, Method: Composition-based stats.
Identities = 34/161 (21%), Positives = 70/161 (43%), Gaps = 21/161 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ +L V+ + A F +N+ L +V ++ + L
Sbjct 248 VETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQA 307
Query 177 -SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G+
Sbjct 308 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IGV 359
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
+LF+ + + + F ++P++ +V +TT D
Sbjct 360 ILFSSAV-YFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGD 399
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 39/273 (14%), Positives = 87/273 (32%), Gaps = 49/273 (18%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
V +D ++ ++ +E E PR ++Q +
Sbjct 123 VNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEE-------RPLPRRDFQRQVWLLFE 175
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI------------------ 468
+ + + L L+SI +F + E+D
Sbjct 176 YPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAS 235
Query 469 ---------LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
++ + I+++ E+L++ FA + S N+ + L+ +V ++ T
Sbjct 236 SGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFS--RNIMN-LIDIVAIIPYFIT 292
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
L G + + L +L ++ + R RI + + L +M
Sbjct 293 LGTELAERQGNGQQAMSLA-------ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 345
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R G ++ ++ IG+ LF + +
Sbjct 346 RELGLLIFFLF-----IGVILFSSAVYFAEADD 373
>sp|Q5F4C0|HVCN1_CHICK Voltage-gated hydrogen channel 1 OS=Gallus
gallus OX=9031 GN=HVCN1 PE=2 SV=1
Length=235
Score = 53.6 bits (127), Expect = 1e-06, Method: Composition-based stats.
Identities = 36/201 (18%), Positives = 84/201 (42%), Gaps = 10/201 (5%)
Query 386 YGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSP---FLQSAQFLFGHYYFDYLGNLIA 442
+ + ++QK NE + + K+ + E F + LF F + +
Sbjct 12 GDDPIQWSNDYQKWENEEEDNGEKDSEIKLEPSRGHVTFQDVMKKLFSSRRFQIVIVFLV 71
Query 443 LANLVSICVFLVLDADVLPAERDD---FILGILNCVFIVYYLLEMLLKVFALGLRGYLSY 499
+ + + + L++D ++ ++ + L+ + +L+E+ K+F G R + +
Sbjct 72 IVDALLVLGELLMDLKIIHPDKYHIAPKVFHYLSLSILTIFLVEVGFKIFVYG-REFFHH 130
Query 500 PSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
V D ++ VV +L++ L H ++ LL LW + R++N +I+ R
Sbjct 131 KFEVLDSIVVVVSFILDLVLLF---REHEFEAVGLLILLRLWRVARIINGIILSVKTRSE 187
Query 560 PSMKLMAVVASTVLGLVQNMR 580
+ + V + V+ ++
Sbjct 188 QQVSKLKQVNLKLATKVEQLQ 208
Score = 38.9 bits (89), Expect = 0.11, Method: Composition-based stats.
Identities = 20/114 (18%), Positives = 43/114 (38%), Gaps = 7/114 (6%)
Query 90 IFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGW 149
+FL++ A + L + P + + + L +F ++ K +++G
Sbjct 68 VFLVIVDALLVLGELLMDLKIIHPDKYHIAP--KVFHYLSLSILTIFLVEVGFKIFVYG- 124
Query 150 AHFQKNLWLLGYLVVLVVSLVDWTVSL----SLVCHEPLRIRRLLRPFFLLQNS 199
F + + + +V+VVS + V L L + RL R ++
Sbjct 125 REFFHHKFEVLDSIVVVVSFILDLVLLFREHEFEAVGLLILLRLWRVARIINGI 178
>sp|Q6DHQ1|HVCN1_DANRE Voltage-gated hydrogen channel 1 OS=Danio
rerio OX=7955 GN=hvcn1 PE=2 SV=1
Length=235
Score = 53.6 bits (127), Expect = 1e-06, Method: Composition-based stats.
Identities = 32/166 (19%), Positives = 77/166 (46%), Gaps = 7/166 (4%)
Query 418 QSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDD---FILGILNC 474
Q F S + L+ F + + + + + + L++D ++ A+ + L+
Sbjct 50 QLSFRDSLRKLYSTERFQIVVVCLVVLDAIFVLCELLIDLSIIEADHHRIAPQVFHYLSL 109
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+ ++++E+ K+FA L +L + VFDG++ VV +L+I + +
Sbjct 110 ALLTFFMVELAGKIFAYRLE-FLHHKFEVFDGIVVVVSFILDIIYI---SKEDAFDAMGL 165
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMR 580
+ LL LW + R++N ++V R ++ + + +++ V ++
Sbjct 166 LILLRLWRVARIINGILVSVQNRANHRVEKLKEINESLVHQVNELK 211
>sp|P16390|KCNA3_MOUSE Potassium voltage-gated channel subfamily
A member 3 OS=Mus musculus OX=10090 GN=Kcna3 PE=1 SV=3
Length=528
Score = 55.1 bits (131), Expect = 1e-06, Method: Composition-based stats.
Identities = 34/161 (21%), Positives = 70/161 (43%), Gaps = 21/161 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ +L V+ + A F +N+ L +V ++ + L
Sbjct 251 VETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQA 310
Query 177 -SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G+
Sbjct 311 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IGV 362
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
+LF+ + + + F ++P++ +V +TT D
Sbjct 363 ILFSSAV-YFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGD 402
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 39/273 (14%), Positives = 87/273 (32%), Gaps = 49/273 (18%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQ 426
V +D ++ ++ +E E PR ++Q +
Sbjct 126 VNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEE-------RPLPRRDFQRQVWLLFE 178
Query 427 FLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI------------------ 468
+ + + L L+SI +F + E+D
Sbjct 179 YPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAP 238
Query 469 ---------LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST 519
++ + I+++ E+L++ FA + S N+ + L+ +V ++ T
Sbjct 239 SGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFS--RNIMN-LIDIVAIIPYFIT 295
Query 520 LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
L G + + L +L ++ + R RI + + L +M
Sbjct 296 LGTELAERQGNGQQAMSLA-------ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 348
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R G ++ ++ IG+ LF + +
Sbjct 349 RELGLLIFFLF-----IGVILFSSAVYFAEADD 376
>sp|Q9ULS6|KCNS2_HUMAN Potassium voltage-gated channel subfamily
S member 2 OS=Homo sapiens OX=9606 GN=KCNS2 PE=1 SV=2
Length=477
Score = 55.1 bits (131), Expect = 2e-06, Method: Composition-based stats.
Identities = 37/244 (15%), Positives = 87/244 (36%), Gaps = 21/244 (9%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+Q ++ S S +E +N+ + + L + +
Sbjct 129 EPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRV 188
Query 434 FDYLGNLIALANLVSICVFLVLD---ADVLPAERDDFILGILNCVFIVYYLLEMLLKV-F 489
F L L+ + +++++C+ + D D +D I+ I ++ E++ +
Sbjct 189 FSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAV 248
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A + N+ D + V + + L V P +L ++ R+ +
Sbjct 249 APDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTP------------TLANLGRVAQV 296
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
L + R RI+ + + S L + + G +L+ + +GI++F V +
Sbjct 297 LRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLL-----YLSVGISIFSVVAYTIE 351
Query 610 GNSS 613
+
Sbjct 352 KEEN 355
Score = 43.6 bits (101), Expect = 0.007, Method: Composition-based stats.
Identities = 26/118 (22%), Positives = 53/118 (45%), Gaps = 11/118 (9%)
Query 126 ESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGYLVVLV---VSLVDWTVSLSLVCH 181
E VE + F +L + + F KN L L+ +V ++LV V S
Sbjct 228 EIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTL 287
Query 182 -------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
+ LR+ R+ R L ++S+ ++ +++S E+ + L L++ + +F++
Sbjct 288 ANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSV 345
>sp|Q9Z0V1|KCND3_MOUSE A-type voltage-gated potassium channel
KCND3 OS=Mus musculus OX=10090 GN=Kcnd3 PE=1 SV=1
Length=655
Score = 55.5 bits (132), Expect = 2e-06, Method: Composition-based stats.
Identities = 42/334 (13%), Positives = 107/334 (32%), Gaps = 29/334 (9%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYR 114
D + + + S + +F + FI V
Sbjct 149 DDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCG 208
Query 115 AAPWEPPCGLTE-------SVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV 166
P E ++ C+++F + ++ + F +++ + +V ++
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIM 268
Query 167 ---VSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
+ LV LR+ R+ R F ++S ++ ++ E+ + L
Sbjct 269 PYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS 283
+ + +F ++ +A + + F ++P S +V +TT D++ +
Sbjct 329 TMAIIIFAT--VMFYA-------EKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIA 379
Query 284 KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
+I + + ++ L +I S F + + + + +
Sbjct 380 GKIFGSI-----CSLSGVLVIALPVPVIVSNFS----RIYHQNQRADKRRAQKKARLARI 430
Query 344 MVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQ 377
V + G+ + K LL ++ +Q
Sbjct 431 RVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEQ 464
Score = 49.7 bits (117), Expect = 8e-05, Method: Composition-based stats.
Identities = 30/263 (11%), Positives = 81/263 (31%), Gaps = 29/263 (11%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQK--VQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ G+ +P+ + + ++ + + + L +
Sbjct 95 LNFYRTGKLH-YPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDS 153
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV--- 454
+ E S+ +++P + + F Y+ ++++ V V
Sbjct 154 ENNQESMPSLSFRQTMWRAFENPHTSTLALV-----FYYVTGFFIAVSVITNVVETVPCG 208
Query 455 ---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
++ ER L+ ++ + +E LL++FA R + V
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRF----------IRSV 258
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ ++++ + Y M + L + VFR + + + ++ T
Sbjct 259 MSIIDVVAIMPY-----YIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 313
Query 572 VLGLVQNMRAFGGILVVVYYVFA 594
+ + L + +FA
Sbjct 314 LKSCASELGFLLFSLTMAIIIFA 336
>sp|O35174|KCNS2_MOUSE Potassium voltage-gated channel subfamily
S member 2 OS=Mus musculus OX=10090 GN=Kcns2 PE=1 SV=1
Length=477
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 38/244 (16%), Positives = 87/244 (36%), Gaps = 21/244 (9%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+Q ++ S S +E +N+ + + L + +
Sbjct 129 EPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRV 188
Query 434 FDYLGNLIALANLVSICVFLVLD---ADVLPAERDDFILGILNCVFIVYYLLEMLLKV-F 489
F L L+ L +++++C+ + D D +D I+ I ++ E++ +
Sbjct 189 FSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAV 248
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A + N+ D + V + + L V P +L ++ R+ +
Sbjct 249 APDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSP------------TLANLGRVAQV 296
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
L + R RI+ + + S L + + G +L+ + +GI++F V +
Sbjct 297 LRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLL-----YLSVGISIFSVVAYTIE 351
Query 610 GNSS 613
+
Sbjct 352 KEEN 355
Score = 43.9 bits (102), Expect = 0.005, Method: Composition-based stats.
Identities = 38/201 (19%), Positives = 80/201 (40%), Gaps = 22/201 (11%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRY---------YSNVCQRTLSFTIFLILFLAFIETP 102
++ + + + + D + +RR YS + + +I ++L
Sbjct 147 SFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCL 206
Query 103 SSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGY 161
+SL + P E P E VE + F +L + + F KN L
Sbjct 207 NSLPDFQIPDSQGNPGEDPR--FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLID 264
Query 162 LVVLV---VSLVDWTVSLSLVCH-------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRW 211
L+ +V ++LV V S + LR+ R+ R L ++S+ ++ +++
Sbjct 265 LMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY 324
Query 212 SLPEMASVGLLLAIHLCLFTM 232
S E+ + L L++ + +F++
Sbjct 325 SYKEVGLLLLYLSVGISIFSV 345
>sp|Q9ER26|KCNS2_RAT Potassium voltage-gated channel subfamily
S member 2 OS=Rattus norvegicus OX=10116 GN=Kcns2 PE=2 SV=1
Length=477
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 38/244 (16%), Positives = 87/244 (36%), Gaps = 21/244 (9%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+Q ++ S S +E +N+ + + L + +
Sbjct 129 EPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRV 188
Query 434 FDYLGNLIALANLVSICVFLVLD---ADVLPAERDDFILGILNCVFIVYYLLEMLLKV-F 489
F L L+ L +++++C+ + D D +D I+ I ++ E++ +
Sbjct 189 FSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAV 248
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
A + N+ D + V + + L V P +L ++ R+ +
Sbjct 249 APDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSP------------TLANLGRVAQV 296
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
L + R RI+ + + S L + + G +L+ + +GI++F V +
Sbjct 297 LRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLL-----YLSVGISIFSVVAYTIE 351
Query 610 GNSS 613
+
Sbjct 352 KEEN 355
Score = 43.9 bits (102), Expect = 0.005, Method: Composition-based stats.
Identities = 38/201 (19%), Positives = 80/201 (40%), Gaps = 22/201 (11%)
Query 52 FIEDAIQYRSINHRVDASSMWLYRRY---------YSNVCQRTLSFTIFLILFLAFIETP 102
++ + + + + D + +RR YS + + +I ++L
Sbjct 147 SFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCL 206
Query 103 SSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGY 161
+SL + P E P E VE + F +L + + F KN L
Sbjct 207 NSLPDFQIPDSQGNPGEDPR--FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLID 264
Query 162 LVVLV---VSLVDWTVSLSLVCH-------EPLRIRRLLRPFFLLQNSSMMKKTLKCIRW 211
L+ +V ++LV V S + LR+ R+ R L ++S+ ++ +++
Sbjct 265 LMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKY 324
Query 212 SLPEMASVGLLLAIHLCLFTM 232
S E+ + L L++ + +F++
Sbjct 325 SYKEVGLLLLYLSVGISIFSV 345
>sp|Q9NSA2|KCND1_HUMAN A-type voltage-gated potassium channel
KCND1 OS=Homo sapiens OX=9606 GN=KCND1 PE=1 SV=2
Length=647
Score = 55.1 bits (131), Expect = 2e-06, Method: Composition-based stats.
Identities = 44/284 (15%), Positives = 100/284 (35%), Gaps = 22/284 (8%)
Query 85 TLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG 144
F I + + +ET S E ++ C+L+F + ++
Sbjct 191 VTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRL 250
Query 145 YLFGWA-HFQKNLWLLGYLVVLV---VSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSS 200
+ F +++ L +V ++ + L+ LR+ R+ R F ++S
Sbjct 251 FAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQ 310
Query 201 MMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPE 260
++ ++ E+ + L + + +F ++ +A + T F ++P
Sbjct 311 GLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA-------EKGTNKTNFTSIPA 361
Query 261 SLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLM 320
+ +V +TT D M+P A IF + ++ G L + L +I S F
Sbjct 362 AFWYTIVTMTTLGYGD-MVP---STIAGKIFGSICSLSGVLVIA-LPVPVIVSNFS---- 412
Query 321 KSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQ 364
+ + + + + + + G + K L+
Sbjct 413 RIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLE 456
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 48/387 (12%), Positives = 104/387 (27%), Gaps = 59/387 (15%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKL 399
+ G Q L + + + E E ++
Sbjct 95 LNFYRTGRLHCPRQECIQAFDEEL-AFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEA 153
Query 400 FNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV----- 454
D + + ++ F Y+ ++++ V +
Sbjct 154 EQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGS 213
Query 455 ---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
+ ER ++ ++ + E LL++FA PS L +V+
Sbjct 214 ARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFA--------APSRC-RFLRSVM 264
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
L+ ++ L Y ++ G L + VFR + + + ++ T
Sbjct 265 SLIDVVAILPYYIGLLVPKNDDVSG------AFVTLRVFRVFRIFKFSRHSQGLRILGYT 318
Query 572 VLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEY 631
+ + L + +FA + +F + +
Sbjct 319 LKSCASELGFLLFSLTMAIIIFATV---MF------------------------YAEKGT 351
Query 632 WANNFDDFAAAL-VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFL 690
NF AA T+ + + S KI F +S V+ + L +
Sbjct 352 NKTNFTSIPAAFWYTIVTMTTLG------YGDMVPSTIAGKI-FGSICSLSGVLVIALPV 404
Query 691 ALILENFLHKWDPRSHLQPLAGTPEAT 717
+I+ NF + +
Sbjct 405 PVIVSNFSRIYHQNQRADKRRAQQKVR 431
>sp|O88758|KCNS1_RAT Potassium voltage-gated channel subfamily
S member 1 OS=Rattus norvegicus OX=10116 GN=Kcns1 PE=2 SV=1
Length=497
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 38/252 (15%), Positives = 89/252 (35%), Gaps = 28/252 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 131 TRPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 190
Query 434 FDYLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 191 FSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIA 250
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D + + + ++ A+
Sbjct 251 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGA-------SG 303
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L D+ +++ + + R R++ + + S L + R G +L+ + +G
Sbjct 304 EELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLL-----YLAVG 358
Query 598 INLFRGVIVALP 609
+++F GV
Sbjct 359 VSVFSGVAYTAE 370
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 44/242 (18%), Positives = 96/242 (40%), Gaps = 38/242 (16%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--- 180
+ +E C+ F+ ++S + L A +N + ++ +VS++ + ++L
Sbjct 240 VLRRLEYFCIAWFSFEVSSRLLL---APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALG 296
Query 181 ----------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA
Sbjct 297 DRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLA 356
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
+ G+ +F+G E+ F +P V +TT DV+ +
Sbjct 357 V--------GVSVFSGVAY---TAEEKNVGFDTIPACWWWGTVSMTTVGYGDVVPETVAG 405
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
A + ++G + ++ L II+++F + + R G R ++LSS+
Sbjct 406 KLAASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQREFEDLLSSV 460
Query 345 VG 346
G
Sbjct 461 DG 462
>sp|Q8TDN2|KCNV2_HUMAN Potassium voltage-gated channel subfamily
V member 2 OS=Homo sapiens OX=9606 GN=KCNV2 PE=1 SV=1
Length=545
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 25/188 (13%), Positives = 68/188 (36%), Gaps = 12/188 (6%)
Query 413 PRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD-----DF 467
P+ ++ + L ++V++ + V + + +
Sbjct 241 PQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRP 300
Query 468 ILGILNCVFIVYYLLEMLLKVFAL-GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLP 526
IL + + + ++ LE LL++ + LR + N+ D ++ +L + +
Sbjct 301 ILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVD-----LVAILPLYLQLLLECF 355
Query 527 HPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG-GI 585
+ S+ + ++L ++ + R RI+ + + + L Q + G +
Sbjct 356 TGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLL 415
Query 586 LVVVYYVF 593
L + +F
Sbjct 416 LFIAMGIF 423
Score = 38.6 bits (88), Expect = 0.24, Method: Composition-based stats.
Identities = 45/232 (19%), Positives = 85/232 (37%), Gaps = 36/232 (16%)
Query 124 LTESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDW---------- 172
+ E VE+LC+ F + ++ F ++ L LV ++ +
Sbjct 301 ILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGH 360
Query 173 -------TVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVG-LLLA 224
+V +R+ R+ R L ++S+ ++ +R VG LLL
Sbjct 361 QRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQC---YQQVGCLLLF 417
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
I + +FT F+ D T F +P S V ++T D+ +
Sbjct 418 IAMGIFT------FSAAVYSVEHDV-PSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLG 470
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGY--LMKSLQTSLFRRRLGT 334
FF + + L + +I+Y++F Y +K+ + + RR G
Sbjct 471 R-----FFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGE 517
>sp|A4K2X4|KCNS1_SAIBB Potassium voltage-gated channel subfamily
S member 1 OS=Saimiri boliviensis boliviensis OX=39432 GN=KCNS1
PE=3 SV=1
Length=529
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 40/254 (16%), Positives = 89/254 (35%), Gaps = 28/254 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 162 TRPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D +V ++ TL
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLID----IVSVLPFYLTLLAGAALGDQGGTGGKEF 337
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + ++ ++ +FR L++ + + +T L + R G +L+ + +G
Sbjct 338 GHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGAT---LKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGN 611
+++F GV
Sbjct 390 VSVFSGVAYTAEKE 403
Score = 47.0 bits (110), Expect = 5e-04, Method: Composition-based stats.
Identities = 42/242 (17%), Positives = 96/242 (40%), Gaps = 37/242 (15%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--- 180
+ +E C+ F+ ++S + L A +N + ++ +VS++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLL---APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALG 327
Query 181 ----------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA
Sbjct 328 DQGGTGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLA 387
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
+ G+ +F+G ++E F +P V +TT DV+ +
Sbjct 388 V--------GVSVFSGVAYT--AEKEEHVGFDTIPACWWWGTVSMTTVGYGDVVPVTVAG 437
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
A + ++G + ++ L II+++F + + R + ++LSS+
Sbjct 438 KLAASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSV 492
Query 345 VG 346
G
Sbjct 493 DG 494
>sp|A4K2W6|KCNS1_AOTNA Potassium voltage-gated channel subfamily
S member 1 OS=Aotus nancymaae OX=37293 GN=KCNS1 PE=3 SV=1
Length=529
Score = 54.7 bits (130), Expect = 2e-06, Method: Composition-based stats.
Identities = 40/254 (16%), Positives = 89/254 (35%), Gaps = 28/254 (11%)
Query 374 SHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYY 433
+ +A E + SV +E + EL R +++ +
Sbjct 162 TRPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKL 221
Query 434 FDYLGNLIALANLVSICVFLVLDADVLP---------------AERDDFILGILNCVFIV 478
F + + LA++ ++C+ + + RDD +L L I
Sbjct 222 FSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEGVRDDPVLRRLEYFCIA 281
Query 479 YYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
++ E+ ++ A R + +P N+ D +V ++ TL
Sbjct 282 WFSFEVSSRLLLAPSTRNFFCHPLNLID----IVSVLPFYLTLLAGAALGDHGGTGGKEF 337
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
L + ++ ++ +FR L++ + + +T L + R G +L+ + +G
Sbjct 338 GHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGAT---LKHSYREVGILLL-----YLAVG 389
Query 598 INLFRGVIVALPGN 611
+++F GV
Sbjct 390 VSVFSGVAYTAEKE 403
Score = 47.0 bits (110), Expect = 5e-04, Method: Composition-based stats.
Identities = 42/242 (17%), Positives = 96/242 (40%), Gaps = 37/242 (15%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVC--- 180
+ +E C+ F+ ++S + L A +N + ++ +VS++ + ++L
Sbjct 271 VLRRLEYFCIAWFSFEVSSRLLL---APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALG 327
Query 181 ----------------HEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLA 224
+ R+ R+ R L ++S+ ++ ++ S E+ + L LA
Sbjct 328 DHGGTGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLA 387
Query 225 IHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSK 284
+ G+ +F+G ++E F +P V +TT DV+ +
Sbjct 388 V--------GVSVFSGVAYT--AEKEEHVGFDTIPACWWWGTVSMTTVGYGDVVPVTVAG 437
Query 285 NRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSM 344
A + ++G + ++ L II+++F + + R + ++LSS+
Sbjct 438 KLAASG-----CILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSV 492
Query 345 VG 346
G
Sbjct 493 DG 494
>sp|Q9P0L9|PK2L1_HUMAN Polycystin-2-like protein 1 OS=Homo sapiens
OX=9606 GN=PKD2L1 PE=1 SV=1
Length=805
Score = 54.7 bits (130), Expect = 3e-06, Method: Composition-based stats.
Identities = 46/269 (17%), Positives = 99/269 (37%), Gaps = 50/269 (19%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
++ CVFI YY++E +L++ LR YLS N+ D L+ ++L ++ + L
Sbjct 356 EVIFCVFIFYYVVEEILELHIHRLR-YLSSIWNILD-LVVILLSIVAVGFHIFRTLEVNR 413
Query 530 WRPEMVGLLSLWDMTRML--------------NMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+++ + + L + + I K M ++ST+
Sbjct 414 LMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARC 473
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
+++ F + +V++ +A +G LF + N
Sbjct 474 AKDILGFAVMFFIVFFAYAQLGYLLFGTQVE----------------------------N 505
Query 636 FDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
F F + T + +++ + +D R GP + + + +N+FLA+I +
Sbjct 506 FSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFV---TYVFFVFFVLLNMFLAIIND 562
Query 696 NFLHKWDP---RSHLQPLAGTPEATYQMT 721
+ + + L+ + Y T
Sbjct 563 TYSEVKEELAGQKDELQLSDLLKQGYNKT 591
Score = 42.0 bits (97), Expect = 0.020, Method: Composition-based stats.
Identities = 41/347 (12%), Positives = 101/347 (29%), Gaps = 52/347 (15%)
Query 102 PSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGY 161
PS T + + W+ E + + + + + ++ + + ++W +
Sbjct 332 PSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELH-IHRLRYLSSIWNILD 390
Query 162 LVVLVVSLVDWTVSLSLVCHEPLRIRRLLRP-------------FFLLQNSSMMKKTLKC 208
LVV+++S+V V R + R F L +
Sbjct 391 LVVILLSIVA-------VGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNA 443
Query 209 IR---------------WSLPEMASVGLLLAIHLCLFTMFGM-LLFAGGKQDDGQDRERL 252
+ ++ +++S A + F + + FA + ++
Sbjct 444 VNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQV 503
Query 253 TYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIY 312
F + + + ++ + D + +F+ + L+N+ AII
Sbjct 504 ENFSTFIKCIFTQFRIIL--GDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIIN 561
Query 313 SQFRGYLMKSLQTSLFRRRLGTRA-------------AFEVLSSMVGEGGAFPQAVGVKP 359
+ + + V G +
Sbjct 562 DTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDF 621
Query 360 QNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRS 406
N L+ L + + + A K G+ +L +E +K+ +L+
Sbjct 622 TNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEE 668
>sp|P16389|KCNA2_HUMAN Potassium voltage-gated channel subfamily
A member 2 OS=Homo sapiens OX=9606 GN=KCNA2 PE=1 SV=2
Length=499
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ + A F N+ + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAV-YFAEADERESQFPSIPDAFWWAVVSMTTVGYGD 379
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/284 (14%), Positives = 87/284 (31%), Gaps = 54/284 (19%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ + +E E RP ++ F
Sbjct 98 LRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-----------RPLPENEFQ 146
Query 423 QSAQFLFG-------HYYFDYLGNLIALANLVSICVFLV--------------------- 454
+ LF + ++ L ++VS C+ +
Sbjct 147 RQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYS 206
Query 455 -LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVL 512
+ I+ + I+++ E L++ FA + G+ + N+ D
Sbjct 207 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID------- 259
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ I + +PE +L ++ + R RI + +
Sbjct 260 -IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
L +MR G ++ ++ IG+ LF + + +
Sbjct 319 QTLKASMRELGLLIFFLF-----IGVILFSSAVYFAEADERESQ 357
>sp|Q9UK17|KCND3_HUMAN A-type voltage-gated potassium channel
KCND3 OS=Homo sapiens OX=9606 GN=KCND3 PE=1 SV=3
Length=655
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 41/321 (13%), Positives = 103/321 (32%), Gaps = 29/321 (9%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYR 114
D + + + S + +F + FI V
Sbjct 149 DDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCG 208
Query 115 AAPWEPPCGLTE-------SVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV 166
P E ++ C+++F + ++ + F +++ + +V ++
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIM 268
Query 167 ---VSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
+ LV LR+ R+ R F ++S ++ ++ E+ + L
Sbjct 269 PYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS 283
+ + +F ++ +A + + F ++P S +V +TT D++ +
Sbjct 329 TMAIIIFAT--VMFYA-------EKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIA 379
Query 284 KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
+I + + ++ L +I S F + + + + +
Sbjct 380 GKIFGSI-----CSLSGVLVIALPVPVIVSNFS----RIYHQNQRADKRRAQKKARLARI 430
Query 344 MVGEGGAFPQAVGVKPQNLLQ 364
V + G+ + K LL
Sbjct 431 RVAKTGSSNAYLHSKRNGLLN 451
Score = 50.1 bits (118), Expect = 8e-05, Method: Composition-based stats.
Identities = 30/263 (11%), Positives = 81/263 (31%), Gaps = 29/263 (11%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQK--VQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ G+ +P+ + + ++ + + + L +
Sbjct 95 LNFYRTGKLH-YPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDS 153
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV--- 454
+ E S+ +++P + + F Y+ ++++ V V
Sbjct 154 ENNQESMPSLSFRQTMWRAFENPHTSTLALV-----FYYVTGFFIAVSVITNVVETVPCG 208
Query 455 ---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
++ ER L+ ++ + +E LL++FA R + V
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRF----------IRSV 258
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ ++++ + Y M + L + VFR + + + ++ T
Sbjct 259 MSIIDVVAIMPY-----YIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 313
Query 572 VLGLVQNMRAFGGILVVVYYVFA 594
+ + L + +FA
Sbjct 314 LKSCASELGFLLFSLTMAIIIFA 336
>sp|Q9TTT5|KCND3_RABIT A-type voltage-gated potassium channel
KCND3 OS=Oryctolagus cuniculus OX=9986 GN=KCND3 PE=2 SV=1
Length=655
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 41/321 (13%), Positives = 103/321 (32%), Gaps = 29/321 (9%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYR 114
D + + + S + +F + FI V
Sbjct 149 DDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCG 208
Query 115 AAPWEPPCGLTE-------SVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV 166
P E ++ C+++F + ++ + F +++ + +V ++
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIM 268
Query 167 ---VSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
+ LV LR+ R+ R F ++S ++ ++ E+ + L
Sbjct 269 PYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS 283
+ + +F ++ +A + + F ++P S +V +TT D++ +
Sbjct 329 TMAIIIFAT--VMFYA-------EKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIA 379
Query 284 KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
+I + + ++ L +I S F + + + + +
Sbjct 380 GKIFGSI-----CSLSGVLVIALPVPVIVSNFS----RIYHQNQRADKRRAQKKARLARI 430
Query 344 MVGEGGAFPQAVGVKPQNLLQ 364
V + G+ + K LL
Sbjct 431 RVAKTGSSNAYLHSKRNGLLN 451
Score = 50.1 bits (118), Expect = 8e-05, Method: Composition-based stats.
Identities = 30/263 (11%), Positives = 81/263 (31%), Gaps = 29/263 (11%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQK--VQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ G+ +P+ + + ++ + + + L +
Sbjct 95 LNFYRTGKLH-YPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDS 153
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV--- 454
+ E S+ +++P + + F Y+ ++++ V V
Sbjct 154 ENNQESMPSLSFRQTMWRAFENPHTSTLALV-----FYYVTGFFIAVSVITNVVETVPCG 208
Query 455 ---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
++ ER L+ ++ + +E LL++FA R + V
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRF----------IRSV 258
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ ++++ + Y M + L + VFR + + + ++ T
Sbjct 259 MSIIDVVAIMPY-----YIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 313
Query 572 VLGLVQNMRAFGGILVVVYYVFA 594
+ + L + +FA
Sbjct 314 LKSCASELGFLLFSLTMAIIIFA 336
>sp|Q9I830|KCNA2_ONCMY Potassium voltage-gated channel subfamily
A member 2 OS=Oncorhynchus mykiss OX=8022 GN=kcna2 PE=2 SV=1
Length=494
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 41/234 (18%), Positives = 81/234 (35%), Gaps = 40/234 (17%)
Query 404 DRSVVKEHPPRPEYQSPFLQSAQFLFG-------HYYFDYLGNLIALANLVSICVFLV-- 454
D VKE RP + F + LF + ++ L ++VS C+ +
Sbjct 128 DEGFVKEEE-RPLPDNEFQRQVWLLFEYPESSGPARIIAIISVMVILISIVSFCLETLPI 186
Query 455 -----LDADVLPAERDDFILGILNCVFI-----------VYYLLEMLLKVFALGLR-GYL 497
+ + + + + F +++ E L+++FA + G+
Sbjct 187 FRNDDDEPHSVFDTNTNTTIYFTSTYFTDPFFILETLCIIWFSFEFLVRLFACPSKSGFF 246
Query 498 SYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+ D VV ++ TLA P +SL +L ++ + R R
Sbjct 247 GNVMNIID----VVAIIPYFITLATELAEKPEDGQAGQQAMSLA----ILRVIRLVRVFR 298
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
I + + L +MR G ++ ++ IG+ LF + +
Sbjct 299 IFKLSRHSKGLQILGQTLKASMRELGLLIFFLF-----IGVILFSSAVYFAEAD 347
Score = 51.6 bits (122), Expect = 2e-05, Method: Composition-based stats.
Identities = 31/164 (19%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
+E LC++ F+ + V+ + + F N+ + +V ++ + L
Sbjct 220 LETLCIIWFSFEFLVRLFACPSKSGFFGNVMNIIDVVAIIPYFITLATELAEKPEDGQAG 279
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 280 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 331
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + E + F+++P++ +V +TT D
Sbjct 332 IGVILFSSAV-YFAEADEPESQFESIPDAFWWAVVSMTTVGYGD 374
>sp|Q9JK97|KCNQ4_MOUSE Potassium voltage-gated channel subfamily
KQT member 4 OS=Mus musculus OX=10090 GN=Kcnq4 PE=2 SV=2
Length=696
Score = 54.0 bits (128), Expect = 4e-06, Method: Composition-based stats.
Identities = 32/191 (17%), Positives = 68/191 (36%), Gaps = 9/191 (5%)
Query 414 RPEYQSPFLQSAQFLFG----HYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
Q + + +++ + ++ ++ + S V VL E + L
Sbjct 74 SSAAQKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECL 133
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
IL V IV + LE +++V++ G F ++ I +A + G
Sbjct 134 LILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAG 193
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
+ + +L R + L + R +R+ ++ S V + + I +V
Sbjct 194 TQGNIFATSAL----RSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLV 249
Query 590 YYVFAIIGINL 600
+FA + L
Sbjct 250 -LIFASFLVYL 259
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 26/185 (14%), Positives = 60/185 (32%), Gaps = 31/185 (17%)
Query 67 DASSMWLYR----RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWE 119
+++ YR Y+ + + + +F I L F + S
Sbjct 74 SSAAQKRYRRLQNWVYNVLERPRGWAFVYHVF-IFLLVF---SCLVLSVLSTIQEHQELA 129
Query 120 PPCGLTESVEVLCLLVFAADLSVKGY----------LFGWAHFQKNLWLLGYLVVLVVSL 169
C L +E + ++VF + ++ + G F + + + +V V S+
Sbjct 130 NECLLI--LEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASV 187
Query 170 --VDWTVSLSLVCHEPLRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGL 221
+ ++ LR R L+ +++ ++ + L +G
Sbjct 188 AVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGF 247
Query 222 LLAIH 226
L+ I
Sbjct 248 LVLIF 252
>sp|Q28293|KCNA2_CANLF Potassium voltage-gated channel subfamily
A member 2 OS=Canis lupus familiaris OX=9615 GN=KCNA2 PE=2
SV=1
Length=499
Score = 53.6 bits (127), Expect = 4e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ + A F N+ + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAV-YFAEADERESQFPSIPDAFWWAVVSMTTVGYGD 379
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/311 (13%), Positives = 90/311 (29%), Gaps = 54/311 (17%)
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
+ + + L+ V LD ++ ++ + +E
Sbjct 71 PLRNEIFFVRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDE 130
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFG-------HYYFDYLGNLIALANLVS 448
E RP ++ F + LF + ++ L ++VS
Sbjct 131 GYIKEEE-----------RPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVS 179
Query 449 ICVFLV----------------------LDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
C+ + + I+ + I+++ E L+
Sbjct 180 FCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLV 239
Query 487 KVFALGLR-GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
+ FA + G+ + N+ D ++ I + +PE
Sbjct 240 RFFACPSKAGFFTNIMNIID--------IVAIIPYFITLGTELAEKPEDAQQGQQAMSLA 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+L ++ + R RI + + L +MR G ++ ++ IG+ LF +
Sbjct 292 ILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF-----IGVILFSSAV 346
Query 606 VALPGNSSLAP 616
+ +
Sbjct 347 YFAEADERESQ 357
>sp|Q5M8L8|HVCN1_XENTR Voltage-gated hydrogen channel 1 OS=Xenopus
tropicalis OX=8364 GN=hvcn1 PE=2 SV=1
Length=230
Score = 52.0 bits (123), Expect = 4e-06, Method: Composition-based stats.
Identities = 28/159 (18%), Positives = 71/159 (45%), Gaps = 14/159 (9%)
Query 402 ELDRSVVKEHPPRPEYQS-PFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVL 460
E+ ++ P P S F + ++LF + F + + + + + + V ++LD ++L
Sbjct 26 EVAHEEEPKNTPHPFIASYSFRGALKWLFSSHKFQIVIICLVILDALFVLVEVLLDLELL 85
Query 461 PAERDD---FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEI 517
+ D I L+ + +++LE+ K++A L + + VFD + V+ +++I
Sbjct 86 AEKVDHIIPEIFHYLSISVLSFFILEIAGKLYAFRLE-FFHHKFEVFDAAIVVISFIIDI 144
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
++ R ++ + L + R+ + + +
Sbjct 145 VYIS---------REDIFNAVGLLILLRLWRVARIVNGI 174
>sp|Q09081|KCNA2_RABIT Potassium voltage-gated channel subfamily
A member 2 OS=Oryctolagus cuniculus OX=9986 GN=KCNA2 PE=1
SV=2
Length=499
Score = 53.6 bits (127), Expect = 5e-06, Method: Composition-based stats.
Identities = 40/284 (14%), Positives = 85/284 (30%), Gaps = 54/284 (19%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ + +E E RP ++ F
Sbjct 98 LRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-----------RPLPENEFQ 146
Query 423 QSAQFLFG-------HYYFDYLGNLIALANLVSICVF----------------LVLDADV 459
+ LF + ++ L ++VS C+ +
Sbjct 147 RQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGMTFHTYS 206
Query 460 LPAERDDFILGILNCVFIV------YYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVL 512
+ FIV ++ E L++ FA + G+ + N+ D
Sbjct 207 NSTAGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID------- 259
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ I + +PE +L ++ + R RI + +
Sbjct 260 -IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
L +MR G ++ ++ IG+ LF + + +
Sbjct 319 QTLKASMRELGLLIFFLF-----IGVILFSSAVYFAEADERDSQ 357
Score = 53.6 bits (127), Expect = 5e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ + A F N+ + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAV-YFAEADERDSQFPSIPDAFWWAVVSMTTVGYGD 379
>sp|P17659|KCNA6_RAT Potassium voltage-gated channel subfamily
A member 6 OS=Rattus norvegicus OX=10116 GN=Kcna6 PE=1 SV=1
Length=530
Score = 53.6 bits (127), Expect = 5e-06, Method: Composition-based stats.
Identities = 41/211 (19%), Positives = 76/211 (36%), Gaps = 36/211 (17%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F +L V+ A F +N+ + LV + + L
Sbjct 267 VETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVS 326
Query 177 -----------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 327 GGSGQNRQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLI 381
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
G++LF+ D F ++P++ +V +TT D+
Sbjct 382 FFLF---IGVILFSSAVYFAEADDVDSL-FPSIPDAFWWAVVTMTTVGYGDMYPMTVGGK 437
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ I + + L +I S F
Sbjct 438 IVGSLCAI-----AGVLTIALPVPVIVSNFN 463
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 23/137 (17%), Positives = 49/137 (36%), Gaps = 7/137 (5%)
Query 477 IVYYLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
IV++ E+L++ A + + N+ D L+ + + + T V R
Sbjct 272 IVWFTFELLVRFSACPSKAAFFRNIMNIID-LVAIFPYFITLGTELVQRHEQQPVSGGSG 330
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+L ++ + R RI + + L +MR G ++ ++
Sbjct 331 QNRQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLF----- 385
Query 596 IGINLFRGVIVALPGNS 612
IG+ LF + +
Sbjct 386 IGVILFSSAVYFAEADD 402
>sp|P63142|KCNA2_RAT Potassium voltage-gated channel subfamily
A member 2 OS=Rattus norvegicus OX=10116 GN=Kcna2 PE=1 SV=1
Length=499
Score = 53.6 bits (127), Expect = 5e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ + A F N+ + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAV-YFAEADERDSQFPSIPDAFWWAVVSMTTVGYGD 379
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/284 (14%), Positives = 87/284 (31%), Gaps = 54/284 (19%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ + +E E RP ++ F
Sbjct 98 LRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-----------RPLPENEFQ 146
Query 423 QSAQFLFG-------HYYFDYLGNLIALANLVSICVFLV--------------------- 454
+ LF + ++ L ++VS C+ +
Sbjct 147 RQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYS 206
Query 455 -LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVL 512
+ I+ + I+++ E L++ FA + G+ + N+ D
Sbjct 207 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID------- 259
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ I + +PE +L ++ + R RI + +
Sbjct 260 -IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
L +MR G ++ ++ IG+ LF + + +
Sbjct 319 QTLKASMRELGLLIFFLF-----IGVILFSSAVYFAEADERDSQ 357
>sp|P63141|KCNA2_MOUSE Potassium voltage-gated channel subfamily
A member 2 OS=Mus musculus OX=10090 GN=Kcna2 PE=1 SV=1
Length=499
Score = 53.6 bits (127), Expect = 5e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 69/164 (42%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ + A F N+ + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAV-YFAEADERDSQFPSIPDAFWWAVVSMTTVGYGD 379
Score = 52.4 bits (124), Expect = 1e-05, Method: Composition-based stats.
Identities = 39/284 (14%), Positives = 87/284 (31%), Gaps = 54/284 (19%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ + +E E RP ++ F
Sbjct 98 LRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-----------RPLPENEFQ 146
Query 423 QSAQFLFG-------HYYFDYLGNLIALANLVSICVFLV--------------------- 454
+ LF + ++ L ++VS C+ +
Sbjct 147 RQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYS 206
Query 455 -LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVL 512
+ I+ + I+++ E L++ FA + G+ + N+ D
Sbjct 207 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID------- 259
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ I + +PE +L ++ + R RI + +
Sbjct 260 -IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILG 318
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
L +MR G ++ ++ IG+ LF + + +
Sbjct 319 QTLKASMRELGLLIFFLF-----IGVILFSSAVYFAEADERDSQ 357
>sp|P56696|KCNQ4_HUMAN Potassium voltage-gated channel subfamily
KQT member 4 OS=Homo sapiens OX=9606 GN=KCNQ4 PE=1 SV=2
Length=695
Score = 53.6 bits (127), Expect = 6e-06, Method: Composition-based stats.
Identities = 31/167 (19%), Positives = 62/167 (37%), Gaps = 5/167 (3%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
+ ++ ++ + S V VL E + L IL V IV + LE +++V++ G
Sbjct 97 WAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGC 156
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
F ++ I +A + G + + +L R + L +
Sbjct 157 CCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSAL----RSMRFLQIL 212
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
R +R+ ++ S V + + I +V +FA + L
Sbjct 213 RMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLV-LIFASFLVYL 258
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 27/185 (15%), Positives = 60/185 (32%), Gaps = 31/185 (17%)
Query 67 DASSMWLYR----RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWE 119
+++ YR Y+ + + + +F I L F + S
Sbjct 73 SSAAHKRYRRLQNWVYNVLERPRGWAFVYHVF-IFLLVF---SCLVLSVLSTIQEHQELA 128
Query 120 PPCGLTESVEVLCLLVFAADLSVKGY----------LFGWAHFQKNLWLLGYLVVLVVSL 169
C L +E + ++VF + V+ + G F + + + +V V S+
Sbjct 129 NECLLI--LEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASV 186
Query 170 --VDWTVSLSLVCHEPLRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGL 221
+ ++ LR R L+ +++ ++ + L +G
Sbjct 187 AVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGF 246
Query 222 LLAIH 226
L+ I
Sbjct 247 LVLIF 251
>sp|Q9XXD1|KVS4_CAEEL Probable voltage-gated potassium channel
subunit kvs-4 OS=Caenorhabditis elegans OX=6239 GN=kvs-4 PE=1
SV=3
Length=503
Score = 53.2 bits (126), Expect = 6e-06, Method: Composition-based stats.
Identities = 36/209 (17%), Positives = 81/209 (39%), Gaps = 28/209 (13%)
Query 121 PCGLTESVEVLCLLVFAADLSVKGYLFGW--AHFQKNLWLLGYLVVL--VVSLVDWTVSL 176
P + +E +C++ F + +K + F++ L ++ L +L ++ ++ +
Sbjct 275 PMPILGYIEYVCIVWFTMEYGLKMLVSAERSKTFRQLLNIIDLLAILPFIIEMLLLIFGI 334
Query 177 S----------LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
S + LR+ R++R L + SS ++ K ++ S ++ + +++
Sbjct 335 STEQLRDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMAMVV--- 391
Query 227 LCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
M G++ F+ + E + F ++P + +V +TT D+
Sbjct 392 -----MTGVIFFS-TLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTVPG-- 443
Query 287 AYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+ G L L L II F
Sbjct 444 --KLVATGAIACGVLVLA-LPITIIVDNF 469
Score = 50.1 bits (118), Expect = 6e-05, Method: Composition-based stats.
Identities = 28/178 (16%), Positives = 68/178 (38%), Gaps = 19/178 (11%)
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDF------------ILGILNCVFIVY 479
F + L ++ + + + + V +R++ ILG + V IV+
Sbjct 230 QAFAVCSVVFVLISISGLVLGSLPELQVATKQRNNLTGEEFTEMEPMPILGYIEYVCIVW 289
Query 480 YLLEMLLKV-FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
+ +E LK+ + N+ D LL ++ ++E+ L ++ L
Sbjct 290 FTMEYGLKMLVSAERSKTFRQLLNIID-LLAILPFIIEMLLLIFGISTE-----QLRDLK 343
Query 539 SLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
+ + R+L +L V R L++ + + T+ + + +++ F+ +
Sbjct 344 GAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKTLKASFRQLGMMAMVVMTGVIFFSTL 401
>sp|P22459|KCNA4_HUMAN Potassium voltage-gated channel subfamily
A member 4 OS=Homo sapiens OX=9606 GN=KCNA4 PE=1 SV=2
Length=653
Score = 53.6 bits (127), Expect = 7e-06, Method: Composition-based stats.
Identities = 35/165 (21%), Positives = 69/165 (42%), Gaps = 25/165 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE +C++ F+ + V+ + A F KN+ + +V ++ + L
Sbjct 374 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQ 433
Query 177 -----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
S +R+ R+ R F L ++S ++ +R S+ E+ L I
Sbjct 434 QQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG-----LLIFFLF-- 486
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + E T+FQ++P++ +V +TT D
Sbjct 487 -IGVILFSSAV-YFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGD 529
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 46/305 (15%), Positives = 105/305 (34%), Gaps = 55/305 (18%)
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R +F+ + GG + V V ++V+ ++A+++ G + E
Sbjct 225 RPSFDAILYYYQSGGRLKRPVNVPFDIF---TEEVKFYQLGEEALLKFREDEG-FVREEE 280
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ NE + + PE SP A + L+ L ++V C+ +
Sbjct 281 DRALPENEFKKQIW-LLFEYPESSSPARGIA----------IVSVLVILISIVIFCLETL 329
Query 455 --------------------LDADVLPAERDDFILGILNCVFIVY-------YLLEMLLK 487
L D ++ I N F + + E +++
Sbjct 330 PEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVR 389
Query 488 VFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
FA + + N+ D +V ++ TL G + + R+
Sbjct 390 CFACPSQALFFKNIMNIID----IVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRI 445
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
+ ++ VFR ++ K + ++ T+ ++ + ++++++F IG+ LF +
Sbjct 446 IRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG------LLIFFLF--IGVILFSSAVY 497
Query 607 ALPGN 611
+
Sbjct 498 FAEAD 502
>sp|P15385|KCNA4_RAT Potassium voltage-gated channel subfamily
A member 4 OS=Rattus norvegicus OX=10116 GN=Kcna4 PE=1 SV=1
Length=655
Score = 53.2 bits (126), Expect = 7e-06, Method: Composition-based stats.
Identities = 35/165 (21%), Positives = 69/165 (42%), Gaps = 25/165 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE +C++ F+ + V+ + A F KN+ + +V ++ + L
Sbjct 376 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQ 435
Query 177 -----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
S +R+ R+ R F L ++S ++ +R S+ E+ L I
Sbjct 436 QQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG-----LLIFFLF-- 488
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + E T+FQ++P++ +V +TT D
Sbjct 489 -IGVILFSSAV-YFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGD 531
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 46/305 (15%), Positives = 105/305 (34%), Gaps = 55/305 (18%)
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R +F+ + GG + V V ++V+ ++A+++ G + E
Sbjct 227 RPSFDAILYYYQSGGRLKRPVNVPFDIF---TEEVKFYQLGEEALLKFREDEG-FVREEE 282
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ NE + + PE SP A + L+ L ++V C+ +
Sbjct 283 DRALPENEFKKQIW-LLFEYPESSSPARGIA----------IVSVLVILISIVIFCLETL 331
Query 455 --------------------LDADVLPAERDDFILGILNCVFIVY-------YLLEMLLK 487
L D ++ I N F + + E +++
Sbjct 332 PEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVR 391
Query 488 VFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
FA + + N+ D +V ++ TL G + + R+
Sbjct 392 CFACPSQALFFKNIMNIID----IVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRI 447
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
+ ++ VFR ++ K + ++ T+ ++ + ++++++F IG+ LF +
Sbjct 448 IRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG------LLIFFLF--IGVILFSSAVY 499
Query 607 ALPGN 611
+
Sbjct 500 FAEAD 504
>sp|Q61923|KCNA6_MOUSE Potassium voltage-gated channel subfamily
A member 6 OS=Mus musculus OX=10090 GN=Kcna6 PE=1 SV=1
Length=529
Score = 53.2 bits (126), Expect = 7e-06, Method: Composition-based stats.
Identities = 41/211 (19%), Positives = 76/211 (36%), Gaps = 36/211 (17%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F +L V+ A F +N+ + LV + + L
Sbjct 266 VETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQSVS 325
Query 177 -----------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 326 GGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLI 380
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
G++LF+ D F ++P++ +V +TT D+
Sbjct 381 FFLF---IGVILFSSAVYFAEADDVDSL-FPSIPDAFWWAVVTMTTVGYGDMYPMTVGGK 436
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ I + + L +I S F
Sbjct 437 IVGSLCAI-----AGVLTIALPVPVIVSNFN 462
Score = 48.2 bits (113), Expect = 2e-04, Method: Composition-based stats.
Identities = 23/137 (17%), Positives = 49/137 (36%), Gaps = 7/137 (5%)
Query 477 IVYYLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
IV++ E+L++ A + + N+ D L+ + + + T V R
Sbjct 271 IVWFTFELLVRFSACPSKAAFFRNIMNIID-LVAIFPYFITLGTELVQRHEQQSVSGGSG 329
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+L ++ + R RI + + L +MR G ++ ++
Sbjct 330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLF----- 384
Query 596 IGINLFRGVIVALPGNS 612
IG+ LF + +
Sbjct 385 IGVILFSSAVYFAEADD 401
>sp|Q28527|KCNA4_MUSPF Potassium voltage-gated channel subfamily
A member 4 OS=Mustela putorius furo OX=9669 GN=KCNA4 PE=2
SV=1
Length=654
Score = 53.2 bits (126), Expect = 7e-06, Method: Composition-based stats.
Identities = 35/165 (21%), Positives = 69/165 (42%), Gaps = 25/165 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE +C++ F+ + V+ + A F KN+ + +V ++ + L
Sbjct 375 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQ 434
Query 177 -----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
S +R+ R+ R F L ++S ++ +R S+ E+ L I
Sbjct 435 QQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG-----LLIFFLF-- 487
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + E T+FQ++P++ +V +TT D
Sbjct 488 -IGVILFSSAV-YFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGD 530
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 44/295 (15%), Positives = 100/295 (34%), Gaps = 35/295 (12%)
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R +F+ + GG + V V ++V+ ++A+++ G + E
Sbjct 226 RPSFDAILYYYQSGGRLKRPVNVPFDIF---TEEVKFYQLGEEALLKFREDEG-FVREEE 281
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIA----------LA 444
+ NE + + PE SP A + + L
Sbjct 282 DRALPENEFKKQIW-LLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLI 340
Query 445 NLVSICVFLVLDADVLPAERDDFILGILNCVFIVY-------YLLEMLLKVFALGLRG-Y 496
+S L D ++ I N F + + E +++ FA + +
Sbjct 341 MALSAGGHSGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALF 400
Query 497 LSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
N+ D +V ++ TL G + + R++ ++ VFR
Sbjct 401 FKNIMNIID----IVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIF 456
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
++ K + ++ T+ ++ + ++++++F IG+ LF + +
Sbjct 457 KLSRHSKGLQILGHTLRASMRELG------LLIFFLF--IGVILFSSAVYFAEAD 503
>sp|Q62897|KCND3_RAT A-type voltage-gated potassium channel KCND3
OS=Rattus norvegicus OX=10116 GN=Kcnd3 PE=1 SV=2
Length=655
Score = 53.2 bits (126), Expect = 7e-06, Method: Composition-based stats.
Identities = 41/321 (13%), Positives = 104/321 (32%), Gaps = 29/321 (9%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYR 114
D + + + + S + +F + FI V
Sbjct 149 DDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCG 208
Query 115 AAPWEPPCGLTE-------SVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLV 166
P E ++ C+++F + ++ + F +++ + +V ++
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIM 268
Query 167 ---VSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLL 223
+ LV LR+ R+ R F ++S ++ ++ E+ + L
Sbjct 269 PYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328
Query 224 AIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYS 283
+ + +F ++ +A + + F ++P S +V +TT D++ +
Sbjct 329 TMAIIIFAT--VMFYA-------EKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIA 379
Query 284 KNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSS 343
+I + + ++ L +I S F + + + + +
Sbjct 380 GKIFGSI-----CSLSGVLVIALPVPVIVSNFS----RIYHQNQRADKRRAQKKARLARI 430
Query 344 MVGEGGAFPQAVGVKPQNLLQ 364
V + G+ + K LL
Sbjct 431 RVAKTGSSNAYLHSKRNGLLN 451
Score = 50.5 bits (119), Expect = 6e-05, Method: Composition-based stats.
Identities = 30/263 (11%), Positives = 81/263 (31%), Gaps = 29/263 (11%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQVLQK--VQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ G+ +P+ + + ++ + + + L +
Sbjct 95 LNFYRTGKLH-YPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNES 153
Query 398 KLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV--- 454
+ E S+ +++P + + F Y+ ++++ V V
Sbjct 154 ENNQESMPSLSFRQTMWRAFENPHTSTLALV-----FYYVTGFFIAVSVITNVVETVPCG 208
Query 455 ---LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVV 511
++ ER L+ ++ + +E LL++FA R + V
Sbjct 209 TVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRF----------IRSV 258
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
+ ++++ + Y M + L + VFR + + + ++ T
Sbjct 259 MSIIDVVAIMPY-----YIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 313
Query 572 VLGLVQNMRAFGGILVVVYYVFA 594
+ + L + +FA
Sbjct 314 LKSCASELGFLLFSLTMAIIIFA 336
>sp|Q7T199|KCA10_CHICK Potassium voltage-gated channel subfamily
A member 10 OS=Gallus gallus OX=9031 GN=KCNA10 PE=2 SV=1
Length=516
Score = 52.8 bits (125), Expect = 8e-06, Method: Composition-based stats.
Identities = 34/164 (21%), Positives = 70/164 (43%), Gaps = 22/164 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
+E C++ F+ +L V+ + F KN+ + +V ++ V T L
Sbjct 279 IETACIIWFSFELFVRFIVCPSKTEFFKNIMNIIDIVSIIPYFVTLTTELIQQSELNGQQ 338
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G
Sbjct 339 NMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IG 390
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
++LF+ D + ++F ++P+ +V +TT D+
Sbjct 391 VILFSSAVYFAEVDEPQ-SHFSSIPDGFWWAVVTMTTVGYGDMC 433
Score = 43.6 bits (101), Expect = 0.007, Method: Composition-based stats.
Identities = 16/127 (13%), Positives = 50/127 (39%), Gaps = 8/127 (6%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPH 527
++ I+++ E+ ++ + + N+ D +V ++ TL +
Sbjct 276 FFVIETACIIWFSFELFVRFIVCPSKTEFFKNIMNIID----IVSIIPYFVTLTTELIQQ 331
Query 528 PGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
+ L+ + R++ ++ VFR ++ K + ++ T+ ++ + L
Sbjct 332 SELNGQQNMSLA---ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 388
Query 588 VVYYVFA 594
+ +F+
Sbjct 389 IGVILFS 395
>sp|Q5TAH2|SL9C2_HUMAN Sodium/hydrogen exchanger 11 OS=Homo sapiens
OX=9606 GN=SLC9C2 PE=1 SV=1
Length=1124
Score = 53.2 bits (126), Expect = 8e-06, Method: Composition-based stats.
Identities = 31/145 (21%), Positives = 55/145 (38%), Gaps = 11/145 (8%)
Query 415 PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC 474
P + FL + F+Y G +I L + + + L A L L +N
Sbjct 590 PPESNTFLTFIFHIVFSEEFEYTGQIINLIYIYPMIIHLWPMARGLNVS----ALISINY 645
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
F+ Y+LE LK+ L + Y N + + V+ ++ V RP+
Sbjct 646 YFMFLYVLESTLKIIILKRK-YFQQCWNTLEFFILVIGIIDIFCVYFVK------LRPDN 698
Query 535 VGLLSLWDMTRMLNMLIVFRFLRII 559
+ L+ L + L ++ +II
Sbjct 699 LALIQLTVIMGYLRIIRFLPLFKII 723
>sp|P22739|KCNA2_XENLA Potassium voltage-gated channel subfamily
A member 2 OS=Xenopus laevis OX=8355 GN=kcna2 PE=1 SV=2
Length=499
Score = 52.8 bits (125), Expect = 8e-06, Method: Composition-based stats.
Identities = 36/164 (22%), Positives = 67/164 (41%), Gaps = 24/164 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ A F NL + +V ++ + L
Sbjct 225 VETLCIIWFSFEFLVRFLACPSKAVFFTNLMNIIDIVAIIPYFITLGTELAEKTEDGQQG 284
Query 177 ----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTM 232
SL +R+ R+ R F L ++S ++ + + S+ E+ L I
Sbjct 285 QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLNASMRELG-----LLIFFLF--- 336
Query 233 FGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ D ER + F ++P++ +V +TT D
Sbjct 337 IGVILFSSAVFFAEAD-ERDSQFPSIPDAFWWAVVSMTTVGYGD 379
Score = 47.4 bits (111), Expect = 4e-04, Method: Composition-based stats.
Identities = 35/262 (13%), Positives = 88/262 (34%), Gaps = 46/262 (18%)
Query 363 LQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFL 422
L+ V LD ++ ++ + +E E RP + F
Sbjct 98 LRRPVNVPLDIFSEEIRFYELGEEAMEIFREDEGFIKEEE-----------RPLPDNEFQ 146
Query 423 QSAQFLFG-------HYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILG- 470
+ LF + + L ++VS C+ + + + + ++
Sbjct 147 KQVWLLFEYPESSGPARIIAIISVTVILISIVSFCLETLPVFRDENEDMHGSGGNYYSYP 206
Query 471 -----------------ILNCVFIVYYLLEMLLKVFALGLRG-YLSYPSNVFDGLLTVVL 512
I+ + I+++ E L++ A + + + N+ D +V
Sbjct 207 NSTVRFQKSNTFTDPFFIVETLCIIWFSFEFLVRFLACPSKAVFFTNLMNIID----IVA 262
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ TL + +SL + R++ ++ VFR ++ K + ++ T+
Sbjct 263 IIPYFITLGTELAEKTEDGQQGQQAMSLA-ILRVIRLVRVFRIFKLSRHSKGLQILGQTL 321
Query 573 LGLVQNMRAFGGILVVVYYVFA 594
++ + L + +F+
Sbjct 322 NASMRELGLLIFFLFIGVILFS 343
>sp|Q03719|KCND1_MOUSE A-type voltage-gated potassium channel
KCND1 OS=Mus musculus OX=10090 GN=Kcnd1 PE=1 SV=1
Length=651
Score = 53.2 bits (126), Expect = 9e-06, Method: Composition-based stats.
Identities = 46/275 (17%), Positives = 97/275 (35%), Gaps = 28/275 (10%)
Query 69 SSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP-------- 120
SS+ + + +F + FI + R P P
Sbjct 166 SSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPSKEQSCGD 225
Query 121 -PCGLTESVEVLCLLVFAADLSVKGYLFGWA-HFQKNLWLLGYLVVLV---VSLVDWTVS 175
++ C+L+F + ++ + F +++ L +V ++ + L
Sbjct 226 RFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKND 285
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
LR+ R+ R F ++S ++ ++ E+ + L + + +F +
Sbjct 286 DVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--V 343
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVF 295
+ +A + T F ++P + +V +TT D M+P A IF +
Sbjct 344 MFYA-------EKGTSKTNFTSIPAAFWYTIVTMTTLGYGD-MVP---STIAGKIFGSIC 392
Query 296 TVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
++ G L + L +I S F + Q + RR
Sbjct 393 SLSGVLVIA-LPVPVIVSNFSR-IYHQNQRADKRR 425
Score = 50.1 bits (118), Expect = 6e-05, Method: Composition-based stats.
Identities = 47/391 (12%), Positives = 109/391 (28%), Gaps = 74/391 (19%)
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
E + + E + + L+ + + +++ + A E+ G
Sbjct 106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEG------ 159
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL-- 453
+ + ++ F Y+ ++++ V
Sbjct 160 ----------PALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP 209
Query 454 VLDADVLPAERDD------FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL 507
P++ ++ ++ + E LL++FA PS L
Sbjct 210 CRGTPRWPSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFA--------APSRC-RFL 260
Query 508 LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+V+ L+ ++ L Y ++ G L + VFR + + + +
Sbjct 261 RSVMSLIDVVAILPYYIGLFVPKNDDVSG------AFVTLRVFRVFRIFKFSRHSQGLRI 314
Query 568 VASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
+ T+ + L + +FA + +F +
Sbjct 315 LGYTLKSCASELGFLLFSLTMAIIIFATV---MF------------------------YA 347
Query 628 QLEYWANNFDDFAAAL-VTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV 686
+ NF AA T+ + + S KI F +S V+ +
Sbjct 348 EKGTSKTNFTSIPAAFWYTIVTMTTLG------YGDMVPSTIAGKI-FGSICSLSGVLVI 400
Query 687 NLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
L + +I+ NF + +
Sbjct 401 ALPVPVIVSNFSRIYHQNQRADKRRAQQKVR 431
>sp|Q96D96|HVCN1_HUMAN Voltage-gated hydrogen channel 1 OS=Homo
sapiens OX=9606 GN=HVCN1 PE=1 SV=1
Length=273
Score = 51.6 bits (122), Expect = 9e-06, Method: Composition-based stats.
Identities = 24/150 (16%), Positives = 67/150 (45%), Gaps = 4/150 (3%)
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDF---ILGILNCVFI 477
F + LF + F + + + + + + L+LD ++ +++++ + ++ +
Sbjct 88 FRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITIL 147
Query 478 VYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
V++++E++ K+F L + + + D ++ VV +L+I L ++ L
Sbjct 148 VFFMMEIIFKLFVFRLE-FFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRL 206
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAV 567
+ + + + + R R + +K M V
Sbjct 207 WRVARIINGIIISVKTRSERQLLRLKQMNV 236
>sp|Q61423|KCNA4_MOUSE Potassium voltage-gated channel subfamily
A member 4 OS=Mus musculus OX=10090 GN=Kcna4 PE=1 SV=2
Length=654
Score = 52.8 bits (125), Expect = 9e-06, Method: Composition-based stats.
Identities = 35/165 (21%), Positives = 69/165 (42%), Gaps = 25/165 (15%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE +C++ F+ + V+ + A F KN+ + +V ++ + L
Sbjct 375 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQ 434
Query 177 -----SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFT 231
S +R+ R+ R F L ++S ++ +R S+ E+ L I
Sbjct 435 QQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG-----LLIFFLF-- 487
Query 232 MFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPD 276
G++LF+ + E T+FQ++P++ +V +TT D
Sbjct 488 -IGVILFSSAV-YFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGD 530
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 46/305 (15%), Positives = 105/305 (34%), Gaps = 55/305 (18%)
Query 335 RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAE 394
R +F+ + GG + V V ++V+ ++A+++ G + E
Sbjct 226 RPSFDAILYYYQSGGRLKRPVNVPFDIF---TEEVKFYQLGEEALLKFREDEG-FVREEE 281
Query 395 EFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV 454
+ NE + + PE SP A + L+ L ++V C+ +
Sbjct 282 DRALPENEFKKQIW-LLFEYPESSSPARGIA----------IVSVLVILISIVIFCLETL 330
Query 455 --------------------LDADVLPAERDDFILGILNCVFIVY-------YLLEMLLK 487
L D ++ I N F + + E +++
Sbjct 331 PEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVR 390
Query 488 VFALGLRG-YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
FA + + N+ D +V ++ TL G + + R+
Sbjct 391 CFACPSQALFFKNIMNIID----IVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRI 446
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
+ ++ VFR ++ K + ++ T+ ++ + ++++++F IG+ LF +
Sbjct 447 IRLVRVFRIFKLSRHSKGLQILGHTLRASMRELG------LLIFFLF--IGVILFSSAVY 498
Query 607 ALPGN 611
+
Sbjct 499 FAEAD 503
>sp|Q95167|KCNB2_CANLF Potassium voltage-gated channel subfamily
B member 2 (Fragment) OS=Canis lupus familiaris OX=9615 GN=KCNB2
PE=1 SV=2
Length=809
Score = 52.8 bits (125), Expect = 1e-05, Method: Composition-based stats.
Identities = 45/264 (17%), Positives = 89/264 (34%), Gaps = 30/264 (11%)
Query 88 FTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF 147
+F++L + + + P VE +C F + ++
Sbjct 199 SNLFIVLSTIALSLNTLPELQEMDEFGQPNDNPQLA---HVEAVCNAWFTMEYLLRFLSS 255
Query 148 -GWAHFQKNLWLLGYLVVL----VVSLVDWTVSLSLV------CHEPLRIRRLLRPFFLL 196
F K + L+ + V + + L + RI R+LR L
Sbjct 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
++S+ ++ +R S E+ + L LA+ + +F+ + FA D T F
Sbjct 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL--VFFAEKDAD-------ATKFT 366
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++P S + +TT D+ + I ++ + L II F
Sbjct 367 SIPASFWWATITMTTVGYGDIYPKTLLGKSVGGLCCIAGVLV-----IALPIPIIVPPFS 421
Query 317 GYLMKSL--QTSLFRRRLGTRAAF 338
+ + + ++ RR RA
Sbjct 422 EFYKEQKRQEKAIKRREALERAKR 445
Score = 52.8 bits (125), Expect = 1e-05, Method: Composition-based stats.
Identities = 33/265 (12%), Positives = 83/265 (31%), Gaps = 20/265 (8%)
Query 340 VLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ 397
+ G+ + + L + ++ L+S + +K L E
Sbjct 100 LNFYRTGKLHMMEEMCALSVGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETM 159
Query 398 KLFNELDRSVVKEHPPRPEYQSP-FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV-- 454
+ + P +S L+ + NL + + +++ + +
Sbjct 160 R--DGEGEEFDNTCCPEKRKKSRDLLEKPNSSVAAKILAIVSNLFIVLSTIALSLNTLPE 217
Query 455 -LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP--SNVFDGLLTVV 511
+ D D+ L + V ++ +E LL+ +LS P F G L V+
Sbjct 218 LQEMDEFGQPNDNPQLAHVEAVCNAWFTMEYLLR--------FLSSPNKWKFFKGPLNVI 269
Query 512 LLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
L+ + L + + ++ ++ + R L++ + + T
Sbjct 270 DLLAILPYYVTIFLTESNKSVLQFQNVR--RVVQIFRIMRILRILKLARHSTGLQSLGFT 327
Query 572 VLGLVQNMRAFGGILVVVYYVFAII 596
+ + L + +F+ +
Sbjct 328 LRRSYNELGLLILFLAMGIMIFSSL 352
>sp|P25122|KCNC1_RAT Voltage-gated potassium channel KCNC1 OS=Rattus
norvegicus OX=10116 GN=Kcnc1 PE=1 SV=1
Length=585
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 43/281 (15%), Positives = 86/281 (31%), Gaps = 49/281 (17%)
Query 74 YRRYY---------SNVCQRTLSFTIFLILFLAFIETPSSLTSTADV------------- 111
+ R + R + F LF + + T +
Sbjct 168 FWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENV 227
Query 112 ----RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF--GWAHFQKNLWLLGYLV-- 163
+ R +E +C++ F + ++ +F F KN + V
Sbjct 228 RNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMR-VVFCPNKVEFIKNSLNIIDFVAI 286
Query 164 ------VLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMA 217
V + L L +R R+LR F L ++ ++ +R S E
Sbjct 287 LPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFL 346
Query 218 SVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDV 277
+ + LA+ + +F G Q + T+F+N+P +V +TT D+
Sbjct 347 LLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDM 406
Query 278 MIPAYSKNRAYAI------------FFIVFTVIGSLFLMNL 306
+S A+ ++ G + + +
Sbjct 407 YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Score = 42.0 bits (97), Expect = 0.022, Method: Composition-based stats.
Identities = 57/394 (14%), Positives = 112/394 (28%), Gaps = 72/394 (18%)
Query 333 GTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
A + + + V + L LD+S A + G
Sbjct 89 EELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDE 148
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF 452
E ++ L S + P ++ + LF Y +A A+L I V
Sbjct 149 LEMTKR----LALSDSPDGRPGGFWRRWQPR-IWALFEDPYSSRYARYVAFASLFFILVS 203
Query 453 L---VLDAD----------------------VLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ L+ + L + V +V++ E L++
Sbjct 204 ITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMR 263
Query 488 VFALGLR-GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
V + ++ N+ D + ++ LE+ +
Sbjct 264 VVFCPNKVEFIKNSLNIIDF-VAILPFYLEVGLSGLSSKAAKDVLG-------------F 309
Query 547 LNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
L ++ R LRI + + V+ T+ L + +FA + +
Sbjct 310 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT--MIYYAE 367
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
I A P + S + F A+VT M +
Sbjct 368 RIGAQPNDPSASEHTHFKNIPIG------------FWWAVVT----MTTLGYGDM----- 406
Query 664 RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y WS + ++ V+ + + + +I+ NF
Sbjct 407 -YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 439
>sp|O35245|PKD2_MOUSE Polycystin-2 OS=Mus musculus OX=10090 GN=Pkd2
PE=1 SV=2
Length=966
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 39/287 (14%), Positives = 104/287 (36%), Gaps = 44/287 (15%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEIST---------- 519
I+ C FI+YY++E +L++ L Y N D ++ V+ +V +
Sbjct 475 EIIFCFFIIYYVVEEILEIRIHRL-SYFRSFWNCLDVVIVVLSVVAMVINIYRMSNAEGL 533
Query 520 --LAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ P + + +++ ++ L+ + + I + M+ +++T+ +
Sbjct 534 LQFLEDQNSFPNFEHVAYWQIQFNNISAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAK 593
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
++ F + +++ +A + +F ++F
Sbjct 594 DLFGFTIMFSIIFLAYAQLAYLVFG----------------------------TQVDDFS 625
Query 638 DFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
F + T + +++ + + +YF + I +N+FLA+I +++
Sbjct 626 TFQECIFTQFRIILG---DINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSY 682
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ + + + + L + L+ D ++E L Q
Sbjct 683 SEVKSDLAQQKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQ 729
Score = 34.7 bits (78), Expect = 4.6, Method: Composition-based stats.
Identities = 29/219 (13%), Positives = 64/219 (29%), Gaps = 22/219 (10%)
Query 223 LAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA-NNPDVMIPA 281
L +F++ A + ++ F E + + ++ N ++
Sbjct 595 LFGFTIMFSII---FLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEI---E 648
Query 282 YSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT------- 334
+ ++F F L+N+ AII + Q
Sbjct 649 EANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQK 708
Query 335 ---RAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLL 391
+ + + + L Q L+ + +A+ K G L
Sbjct 709 ALVKLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQEL 768
Query 392 SAEEFQKLFNELDRS-----VVKEHPPRPEYQSPFLQSA 425
+ E Q++ ++L++ + PRP F +S
Sbjct 769 TEREHQQMRDDLEKEREDLDLEHSSLPRPMSSRSFPRSL 807
>sp|Q9Z351|KCNQ2_MOUSE Potassium voltage-gated channel subfamily
KQT member 2 OS=Mus musculus OX=10090 GN=Kcnq2 PE=1 SV=1
Length=759
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 36/234 (15%), Positives = 76/234 (32%), Gaps = 31/234 (13%)
Query 383 VRSYGSVLLSAEEFQKLFNELDRS-----VVKEHPPRPEYQSPFLQSAQFLFGHYY-FDY 436
G++L++ E K + L + + P R + + + +
Sbjct 34 STRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAF 93
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
+ + + S V V + + L IL V IV + +E ++++A
Sbjct 94 IYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCR 153
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P V D +++L+ I+ LA + + R
Sbjct 154 YRGWRGRLKFARKPFCVID----IMVLIASIAVLAAGSQGNVFATSAL----------RS 199
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
L L + R +R+ ++ S V + + I + + A + L
Sbjct 200 LRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLC-LILASFLVYL 252
Score = 50.1 bits (118), Expect = 7e-05, Method: Composition-based stats.
Identities = 48/356 (13%), Positives = 111/356 (31%), Gaps = 65/356 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
R ++ + + +F L L+ T +++ G +E++ ++V
Sbjct 89 RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSE------------GALYILEIVTIVV 136
Query 136 FAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSLVDWTVSL--SLVCHEP 183
F + V+ + G W F + + + ++VL+ S+ ++
Sbjct 137 FGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSA 196
Query 184 LRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
LR R L+ +++ ++ + L +G L I F + L
Sbjct 197 LRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLIL----ASFLVYL 252
Query 238 FAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN--------RAYA 289
++ +F ++L L+ LTT D ++ +
Sbjct 253 ---------AEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVS 303
Query 290 IFFIVFTVIGSLFLMNLLTAIIYSQFRG---------YLMKSLQTSLFRRRLGTRAAFEV 340
F + ++GS F + + F + R + ++
Sbjct 304 FFALPAGILGSGFALKVQEQHRPKHFEKRRNPAAGLIQSAWRFYATNLSR-TDLHSTWQY 362
Query 341 LSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEF 396
V P + P N L++L+ ++ S + S +S ++
Sbjct 363 YERTV----TVPMYRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDR 414
>sp|P17658|KCNA6_HUMAN Potassium voltage-gated channel subfamily
A member 6 OS=Homo sapiens OX=9606 GN=KCNA6 PE=1 SV=1
Length=529
Score = 51.6 bits (122), Expect = 2e-05, Method: Composition-based stats.
Identities = 40/211 (19%), Positives = 76/211 (36%), Gaps = 36/211 (17%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F +L V+ F +N+ + LV + + L
Sbjct 266 VETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPAS 325
Query 177 -----------SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAI 225
SL +R+ R+ R F L ++S ++ K ++ S+ E+ L I
Sbjct 326 GGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG-----LLI 380
Query 226 HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN 285
G++LF+ D + F ++P++ +V +TT D+
Sbjct 381 FFLF---IGVILFSSAVYFAEADDDDSL-FPSIPDAFWWAVVTMTTVGYGDMYPMTVGGK 436
Query 286 RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
++ I + + L +I S F
Sbjct 437 IVGSLCAI-----AGVLTIALPVPVIVSNFN 462
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 22/138 (16%), Positives = 49/138 (36%), Gaps = 7/138 (5%)
Query 477 IVYYLLEMLLKVFALGLR-GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
IV++ E+L++ A + + N+ D L+ + + + T V +
Sbjct 271 IVWFTFELLVRFSACPSKPAFFRNIMNIID-LVAIFPYFITLGTELVQQQEQQPASGGGG 329
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
+L ++ + R RI + + L +MR G ++ ++
Sbjct 330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLF----- 384
Query 596 IGINLFRGVIVALPGNSS 613
IG+ LF + +
Sbjct 385 IGVILFSSAVYFAEADDD 402
>sp|O88943|KCNQ2_RAT Potassium voltage-gated channel subfamily
KQT member 2 OS=Rattus norvegicus OX=10116 GN=Kcnq2 PE=1 SV=1
Length=852
Score = 52.0 bits (123), Expect = 2e-05, Method: Composition-based stats.
Identities = 36/234 (15%), Positives = 76/234 (32%), Gaps = 31/234 (13%)
Query 383 VRSYGSVLLSAEEFQKLFNELDRS-----VVKEHPPRPEYQSPFLQSAQFLFGHYY-FDY 436
G++L++ E K + L + + P R + + + +
Sbjct 34 STRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAF 93
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
+ + + S V V + + L IL V IV + +E ++++A
Sbjct 94 IYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCR 153
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P V D +++L+ I+ LA + + R
Sbjct 154 YRGWRGRLKFARKPFCVID----IMVLIASIAVLAAGSQGNVFATSAL----------RS 199
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
L L + R +R+ ++ S V + + I + + A + L
Sbjct 200 LRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLC-LILASFLVYL 252
Score = 49.7 bits (117), Expect = 8e-05, Method: Composition-based stats.
Identities = 37/258 (14%), Positives = 86/258 (33%), Gaps = 51/258 (20%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
R ++ + + +F L L+ T +++ G +E++ ++V
Sbjct 89 RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSE------------GALYILEIVTIVV 136
Query 136 FAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSLVDWTVSL--SLVCHEP 183
F + V+ + G W F + + + ++VL+ S+ ++
Sbjct 137 FGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSA 196
Query 184 LRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
LR R L+ +++ ++ + L +G L I F + L
Sbjct 197 LRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLIL----ASFLVYL 252
Query 238 FAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN--------RAYA 289
++ +F ++L L+ LTT D ++ +
Sbjct 253 ---------AEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVS 303
Query 290 IFFIVFTVIGSLFLMNLL 307
F + ++GS F + +
Sbjct 304 FFALPAGILGSGFALKVQ 321
>sp|Q16322|KCA10_HUMAN Potassium voltage-gated channel subfamily
A member 10 OS=Homo sapiens OX=9606 GN=KCNA10 PE=1 SV=2
Length=511
Score = 51.3 bits (121), Expect = 2e-05, Method: Composition-based stats.
Identities = 35/164 (21%), Positives = 70/164 (43%), Gaps = 22/164 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLG-------YLVVLVVSLVDWT-----V 174
VE C++ F +L ++ + F +N+ + Y L+ LV T
Sbjct 274 VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQ 333
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G
Sbjct 334 NMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IG 385
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
++LF+ D E ++F ++P+ +V +TT D+
Sbjct 386 VILFSSAVYFAEVD-EPESHFSSIPDGFWWAVVTMTTVGYGDMC 428
Score = 39.3 bits (90), Expect = 0.12, Method: Composition-based stats.
Identities = 43/335 (13%), Positives = 92/335 (27%), Gaps = 31/335 (9%)
Query 289 AIFFIVFTVIGSLFLMNLLTAIIY-SQFRGYLMKSLQTSLFRRRL----GTRAAFEVLSS 343
++ + G F L T + G K +Q R R +F+ +
Sbjct 84 GNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILY 143
Query 344 MVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLF- 400
GG + V ++ ++ + E LL + + F
Sbjct 144 YYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFW 203
Query 401 ----NELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD 456
S + + L F L + + VL
Sbjct 204 LLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLS 263
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
+ ++ IV++ E++L+ + D ++ ++
Sbjct 264 QTMFTDP-----FFMVESTCIVWFTFELVLRFVVCPSKT---------DFFRNIMNIIDI 309
Query 517 ISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLV 576
IS + + E +L ++ + R RI + + L
Sbjct 310 ISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLK 369
Query 577 QNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
+MR G ++ ++ IG+ LF + +
Sbjct 370 ASMRELGLLIFFLF-----IGVILFSSAVYFAEVD 399
>sp|O43526|KCNQ2_HUMAN Potassium voltage-gated channel subfamily
KQT member 2 OS=Homo sapiens OX=9606 GN=KCNQ2 PE=1 SV=2
Length=872
Score = 51.6 bits (122), Expect = 3e-05, Method: Composition-based stats.
Identities = 36/234 (15%), Positives = 76/234 (32%), Gaps = 31/234 (13%)
Query 383 VRSYGSVLLSAEEFQKLFNELDRS-----VVKEHPPRPEYQSPFLQSAQFLFGHYY-FDY 436
G++L++ E K + L + + P R + + + +
Sbjct 34 STRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAF 93
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
+ + + S V V + + L IL V IV + +E ++++A
Sbjct 94 IYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCR 153
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P V D +++L+ I+ LA + + R
Sbjct 154 YRGWRGRLKFARKPFCVID----IMVLIASIAVLAAGSQGNVFATSAL----------RS 199
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
L L + R +R+ ++ S V + + I + + A + L
Sbjct 200 LRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLC-LILASFLVYL 252
Score = 49.7 bits (117), Expect = 9e-05, Method: Composition-based stats.
Identities = 37/258 (14%), Positives = 86/258 (33%), Gaps = 51/258 (20%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
R ++ + + +F L L+ T +++ G +E++ ++V
Sbjct 89 RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSE------------GALYILEIVTIVV 136
Query 136 FAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSLVDWTVSL--SLVCHEP 183
F + V+ + G W F + + + ++VL+ S+ ++
Sbjct 137 FGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSA 196
Query 184 LRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLL 237
LR R L+ +++ ++ + L +G L I F + L
Sbjct 197 LRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLIL----ASFLVYL 252
Query 238 FAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN--------RAYA 289
++ +F ++L L+ LTT D ++ +
Sbjct 253 ---------AEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVS 303
Query 290 IFFIVFTVIGSLFLMNLL 307
F + ++GS F + +
Sbjct 304 FFALPAGILGSGFALKVQ 321
>sp|P34586|TRPL_CAEEL Transient-receptor-potential-like protein
OS=Caenorhabditis elegans OX=6239 GN=trp-1 PE=2 SV=3
Length=1027
Score = 51.6 bits (122), Expect = 3e-05, Method: Composition-based stats.
Identities = 30/222 (14%), Positives = 79/222 (36%), Gaps = 30/222 (14%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
G + Y+ N D L+ + L L+ Y + P + + W + +
Sbjct 459 GFKRYMRQWWNWLDFLMICLYLCTISIRLSAYYIFTYREDPYRYTVRTYWTSEEPMLVAE 518
Query 552 VF----------RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLF 601
R + + + + + ++ ++ ++ F I V++ F+I L+
Sbjct 519 ALFAVGNVFSFARIIYLFQTNPYLGPLQISLGCMLVDVAKFCFIFVLIISSFSIGLAQLY 578
Query 602 RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT----LWNLMVVNNWQV 657
+ C ++ +N F A + +T L+++ + V
Sbjct 579 WYY------------DPNTDVCLPGATCKHSSNVFSSIADSYLTLLWSLFSITKPEDTDV 626
Query 658 FLDA-YRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
+ ++ G F+++ S ++ +N+ +A++ +F
Sbjct 627 VENHKITQWVGQGM---FIMYHCTSIIVLLNMLIAMMSHSFQ 665
Score = 42.0 bits (97), Expect = 0.023, Method: Composition-based stats.
Identities = 31/228 (14%), Positives = 72/228 (32%), Gaps = 46/228 (20%)
Query 134 LVFAADLSVKG------YLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLR-- 185
LVF + + + G+ + + W +++ + L ++ LS R
Sbjct 439 LVFTWVIGMLWSEIKQLWEEGFKRYMRQWWNWLDFLMICLYLCTISIRLSAYYIFTYRED 498
Query 186 ----IRR----------LLRPFFLLQNSSMMKKTLKCIRWSLPEMA-----------SVG 220
R + F + N + + + + P + V
Sbjct 499 PYRYTVRTYWTSEEPMLVAEALFAVGNVFSFARIIY-LFQTNPYLGPLQISLGCMLVDVA 557
Query 221 LLLAIHLCL---FTMFGMLLFAGGKQDDG------QDRERLTYFQNLPESLTSL---LVL 268
I + + F++ L+ + + F ++ +S +L L
Sbjct 558 KFCFIFVLIISSFSIGLAQLYWYYDPNTDVCLPGATCKHSSNVFSSIADSYLTLLWSLFS 617
Query 269 LTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFR 316
+T + DV+ FI++ + L+N+L A++ F+
Sbjct 618 ITKPEDTDVVENHKITQWVGQGMFIMYHCTSIIVLLNMLIAMMSHSFQ 665
>sp|Q13563|PKD2_HUMAN Polycystin-2 OS=Homo sapiens OX=9606 GN=PKD2
PE=1 SV=3
Length=968
Score = 51.3 bits (121), Expect = 3e-05, Method: Composition-based stats.
Identities = 38/287 (13%), Positives = 98/287 (34%), Gaps = 44/287 (15%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGL------------LTVVLLVLEI 517
I+ C FI YY++E +L++ L Y N D + + V +
Sbjct 477 EIIFCFFIFYYVVEEILEIRIHKL-HYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535
Query 518 STLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQ 577
+ P + + ++ + + + + I + M+ +++T+ +
Sbjct 536 LQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAK 595
Query 578 NMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFD 637
++ F + +++ +A + +F ++F
Sbjct 596 DLFGFAIMFFIIFLAYAQLAYLVFG----------------------------TQVDDFS 627
Query 638 DFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
F + T + +++ + + IYF + I +N+FLA+I + +
Sbjct 628 TFQECIFTQFRIILG---DINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTY 684
Query 698 LHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ 744
+ + + + + L + L++ D+++E L Q
Sbjct 685 SEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQ 731
Score = 34.7 bits (78), Expect = 3.6, Method: Composition-based stats.
Identities = 43/341 (13%), Positives = 98/341 (29%), Gaps = 59/341 (17%)
Query 131 LCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLL 190
+ + + ++ H+ ++ W + V +S+ + R +
Sbjct 482 FFIFYYVVEEILE-IRIHKLHYFRSFWNCLDV-------VIVVLSVVAIGINIYRTSNVE 533
Query 191 RPFFLLQ------NSSMM---KKTLKCIRWSLPEMASVGLLLAIHL-------------- 227
L+ N + + I + + V + L +
Sbjct 534 VLLQFLEDQNTFPNFEHLAYWQIQFNNI--AAVTVFFVWIKLFKFINFNRTMSQLSTTMS 591
Query 228 ------CLFTMFGMLLF-AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTA-NNPDVMI 279
F + ++F A + ++ F E + + ++ N ++
Sbjct 592 RCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEI-- 649
Query 280 PAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGT-RAAF 338
+ I+F F L+N+ AII + Q R +
Sbjct 650 -EEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGY 708
Query 339 E--------VLSSMVGEGGAFPQAVGVKPQNLL-QVLQKVQLDSSHKQAMMEKVRSYGSV 389
+++ + Q G + L Q L+ + +A+ K G
Sbjct 709 HKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQ 768
Query 390 LLSAEEFQKLFNELDRSVV-----KEHPPRPEYQSPFLQSA 425
L+ E Q++ ++L++ PRP F +S
Sbjct 769 ELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSL 809
>sp|B2RQA1|KCA10_MOUSE Potassium voltage-gated channel subfamily
A member 10 OS=Mus musculus OX=10090 GN=Kcna10 PE=2 SV=1
Length=511
Score = 50.9 bits (120), Expect = 4e-05, Method: Composition-based stats.
Identities = 36/164 (22%), Positives = 70/164 (43%), Gaps = 22/164 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLG-------YLVVLVVSLVDWT-----V 174
VE C++ F +L ++ + F KN+ + Y L+ LV T
Sbjct 274 VESTCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQ 333
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++SL +R+ R+ R F L ++S ++ + ++ S+ E+ L I G
Sbjct 334 NMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG-----LLIFFLF---IG 385
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
++LF+ D E ++F ++P+ +V +TT D+
Sbjct 386 VILFSSAVYFAEVD-EPESHFSSIPDGFWWAVVTMTTVGYGDMC 428
Score = 40.5 bits (93), Expect = 0.064, Method: Composition-based stats.
Identities = 45/337 (13%), Positives = 95/337 (28%), Gaps = 35/337 (10%)
Query 289 AIFFIVFTVIGSLFLMNLLTAIIY-SQFRGYLMKSLQTSLFRRRL----GTRAAFEVLSS 343
++ + G F L T + G K +Q R R +F+ +
Sbjct 84 GNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILY 143
Query 344 MVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFN 401
GG + V ++ ++ + E LL +F + F
Sbjct 144 YYQSGGKIRRPANVPIDVFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFW 203
Query 402 ELDRSVVKEHPPR-----PEYQSPFLQSAQFLFGHYYF--DYLGNLIALANLVSICVFLV 454
L R + L F D ++ ++ + L
Sbjct 204 LLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLS 263
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLV 514
P ++ IV++ E++L+ + D ++ ++
Sbjct 264 QTMFTDP-------FFMVESTCIVWFTFELVLRFVVCPSKT---------DFFKNIMNII 307
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
IS + + E +L ++ + R RI + +
Sbjct 308 DIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQT 367
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
L +MR G ++ ++ IG+ LF + +
Sbjct 368 LKASMRELGLLIFFLF-----IGVILFSSAVYFAEVD 399
>sp|Q9VJJ7|TRPG_DROME Transient receptor potential-gamma protein
OS=Drosophila melanogaster OX=7227 GN=Trpgamma PE=1 SV=2
Length=1128
Score = 50.9 bits (120), Expect = 4e-05, Method: Composition-based stats.
Identities = 37/229 (16%), Positives = 82/229 (36%), Gaps = 28/229 (12%)
Query 488 VFALGLRGYLSYPSNVFDG----LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
++ +GL+ YL+ NV D L + + +S V + +
Sbjct 429 LWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIYNSHATDLPRERWDAW 488
Query 544 TRML---------NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
ML N+ + + I + + ++ +V ++ F + V+V + F
Sbjct 489 DPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFG 548
Query 595 IIGINLF-------RGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNF---DDFAAALV 644
L + + S+L NG+ + ++N F A+
Sbjct 549 SGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVF 608
Query 645 TLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALI 693
L +L LD + ++ W + F + +++ V+ +NL +A++
Sbjct 609 GLIDLDSFE-----LDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMM 652
>sp|P15388|KCNC1_MOUSE Voltage-gated potassium channel KCNC1 OS=Mus
musculus OX=10090 GN=Kcnc1 PE=1 SV=1
Length=511
Score = 50.5 bits (119), Expect = 4e-05, Method: Composition-based stats.
Identities = 37/217 (17%), Positives = 74/217 (34%), Gaps = 23/217 (11%)
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLF--GWAHFQKNLWLLGYLV------ 163
+ R +E +C++ F + ++ +F F KN + V
Sbjct 232 QVRYYREAETEAFLTYIEGVCVVWFTFEFLMR-VVFCPNKVEFIKNSLNIIDFVAILPFY 290
Query 164 --VLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGL 221
V + L L +R R+LR F L ++ ++ +R S E + +
Sbjct 291 LEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 350
Query 222 LLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
LA+ + +F G Q + T+F+N+P +V +TT D+
Sbjct 351 FLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQT 410
Query 282 YSKNRAYAI------------FFIVFTVIGSLFLMNL 306
+S A+ ++ G + + +
Sbjct 411 WSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Score = 40.1 bits (92), Expect = 0.084, Method: Composition-based stats.
Identities = 57/394 (14%), Positives = 112/394 (28%), Gaps = 72/394 (18%)
Query 333 GTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
A + + + V + L LD+S A + G
Sbjct 89 EELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDE 148
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF 452
E ++ L S + P ++ + LF Y +A A+L I V
Sbjct 149 LEMTKR----LALSDSPDGRPGGFWRRWQPR-IWALFEDPYSSRYARYVAFASLFFILVS 203
Query 453 L---VLDAD----------------------VLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ L+ + L + V +V++ E L++
Sbjct 204 ITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMR 263
Query 488 VFALGLR-GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
V + ++ N+ D + ++ LE+ +
Sbjct 264 VVFCPNKVEFIKNSLNIIDF-VAILPFYLEVGLSGLSSKAAKDVLG-------------F 309
Query 547 LNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
L ++ R LRI + + V+ T+ L + +FA + +
Sbjct 310 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT--MIYYAE 367
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
I A P + S + F A+VT M +
Sbjct 368 RIGAQPNDPSASEHTHFKNIPIG------------FWWAVVT----MTTLGYGDM----- 406
Query 664 RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y WS + ++ V+ + + + +I+ NF
Sbjct 407 -YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 439
>sp|Q9MYS6|KCNQ1_RABIT Potassium voltage-gated channel subfamily
KQT member 1 OS=Oryctolagus cuniculus OX=9986 GN=KCNQ1 PE=2
SV=3
Length=661
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 28/215 (13%), Positives = 73/215 (34%), Gaps = 16/215 (7%)
Query 384 RSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIAL 443
+S + +++ + + H + + + + Y+F ++
Sbjct 77 DQGPQPPVSLDPRVSIYSVRRPLLARTHI-QGRVYNFLERPTGWKCFAYHFTVFLIVLVC 135
Query 444 ANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV 503
+F VL A L + V +V++ E ++++++ G R
Sbjct 136 L------IFSVLSTIEQYATLATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGR 189
Query 504 FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK 563
+ ++ I +A + G + ++ + R + L + R L +
Sbjct 190 LRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSA----IRGIRFLQILRMLHVDRQGG 245
Query 564 LMAVVASTVL----GLVQNM-RAFGGILVVVYYVF 593
++ S V L+ + F G++ Y+V+
Sbjct 246 TWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 280
Score = 42.0 bits (97), Expect = 0.021, Method: Composition-based stats.
Identities = 44/261 (17%), Positives = 89/261 (34%), Gaps = 42/261 (16%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST + A G +E++
Sbjct 108 RVYNFLERPTGWKCFAYHFTVFLIVLVCLIFSVLSTIEQYATLA-----TGTLFWMEIVL 162
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + V+ + G LW + L+V+V S+V V
Sbjct 163 VVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFA 222
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 223 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 278
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSKNRAYAIF 291
+ L + D + F + ++L +V +TT D + + +++F
Sbjct 279 VYL----AEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 334
Query 292 FIVFT-----VIGSLFLMNLL 307
I F ++GS F + +
Sbjct 335 AISFFALPAGILGSGFALKVQ 355
>sp|Q5M7E9|HVCN1_XENLA Voltage-gated hydrogen channel 1 OS=Xenopus
laevis OX=8355 GN=hvcn1 PE=2 SV=1
Length=230
Score = 49.0 bits (115), Expect = 5e-05, Method: Composition-based stats.
Identities = 28/169 (17%), Positives = 73/169 (43%), Gaps = 14/169 (8%)
Query 389 VLLSAEEFQKLFNELDRSVVKEHPPRPEYQS-PFLQSAQFLFGHYYFDYLGNLIALANLV 447
E+++ E+ ++ P P S F + ++L + F + + + + +
Sbjct 13 DDTKKREWKQEDVEVAYEEPLKNTPHPFIASYSFRGALKWLLSSHKFQIVIICLVILDAL 72
Query 448 SICVFLVLDADVLPAERDD---FILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVF 504
+ V ++LD ++L + D I L+ + +++LE+ K++A L + + VF
Sbjct 73 FVLVEVLLDLELLAEKVDHIIPEIFHYLSISVLTFFILEIAGKLYAFRLE-FFHHKFEVF 131
Query 505 DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
D + V+ +++I ++ R ++ + L + R+ + +
Sbjct 132 DAAIVVISFIIDIVYIS---------REDIFNAVGLLILLRLWRVARIV 171
>sp|Q8BZB3|TM266_MOUSE Transmembrane protein 266 OS=Mus musculus
OX=10090 GN=Tmem266 PE=1 SV=3
Length=538
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 22/114 (19%), Positives = 50/114 (44%), Gaps = 5/114 (4%)
Query 439 NLIALANLVSICVFLVLDADVLPAERDDF-----ILGILNCVFIVYYLLEMLLKVFALGL 493
L+A LV I + L L D + + ++ ++ V + + E +L++ LG+
Sbjct 103 FLVACVILVVILLTLELLIDTKLLQFSNAFQFAGVIHWISLVILSVFFSETVLRIVVLGI 162
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
Y+ VFDG + ++ L +++ P ++ + +W + R++
Sbjct 163 WDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMFRIWRVKRVI 216
>sp|P17971|KCNAL_DROME Potassium voltage-gated channel protein
Shal OS=Drosophila melanogaster OX=7227 GN=Shal PE=1 SV=2
Length=571
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 52/363 (14%), Positives = 126/363 (35%), Gaps = 28/363 (8%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEP---PCG-----LTES 127
+ S +F + FI V P PCG +
Sbjct 172 WRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFC 231
Query 128 VEVLCLLVFAADLSVKGYLFGWA-HFQKNLWLLGYLVVLVVSLVDWTVSLSL---VCHEP 183
++ C+++F A+ ++ + F +++ + +V ++ + ++ +
Sbjct 232 LDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVT 291
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
LR+ R+ R F ++S ++ ++ E+ + LA+ + +F ++ +A
Sbjct 292 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFAT--VMFYAEKNV 349
Query 244 DDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
+ T F ++P + +V +TT D++ + + + + +
Sbjct 350 NG-------TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGV-----CSLSGVLV 397
Query 304 MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLL 363
+ L +I S F + Q + R+ + + G AF
Sbjct 398 IALPVPVIVSNFSR-IYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWA 456
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
++LD +++ + +++ + + + + F EL+ P RP SP
Sbjct 457 AQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPF-NGQPKRPGSPSPMAS 515
Query 424 SAQ 426
A
Sbjct 516 PAH 518
Score = 45.5 bits (106), Expect = 0.002, Method: Composition-based stats.
Identities = 40/303 (13%), Positives = 85/303 (28%), Gaps = 43/303 (14%)
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
E L+S E F V + + + +++ + + + L
Sbjct 107 PKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTN 166
Query 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
+ + ++ F Y+ ++++ V V
Sbjct 167 MR------------------QKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP 208
Query 456 DADVLP-------AERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL 508
ER + L+ ++ + E LL++FA R
Sbjct 209 CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKF----------- 257
Query 509 TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVV 568
V V+ I + + G +S +T L + VFR + + + ++
Sbjct 258 --VRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVT--LRVFRVFRIFKFSRHSQGLRIL 313
Query 569 ASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQ 628
T+ + L + +FA + +F N + PA +
Sbjct 314 GYTLKSCASELGFLVFSLAMAIIIFATV---MFYAEKNVNGTNFTSIPAAFWYTIVTMTT 370
Query 629 LEY 631
L Y
Sbjct 371 LGY 373
>sp|Q8HYZ1|KCND2_MUSPF A-type voltage-gated potassium channel
KCND2 OS=Mustela putorius furo OX=9669 GN=KCND2 PE=2 SV=1
Length=630
Score = 50.5 bits (119), Expect = 5e-05, Method: Composition-based stats.
Identities = 30/224 (13%), Positives = 85/224 (38%), Gaps = 29/224 (13%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-------V 179
++ C+++F + ++ + ++ ++ ++ VV+++ + + L +
Sbjct 231 CLDTACVMIFTVEYLLRLAA-APSRYRFVRSVMS--IIDVVAILPYYIGLVMTDNEDVSG 287
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR+ R+ R F ++S ++ ++ E+ + L + + +F ++ +A
Sbjct 288 AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA 345
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ + F ++P + +V +TT D++ + +I +
Sbjct 346 -------EKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSI-----CSLS 393
Query 300 SLFLMNLLTAIIYSQF-----RGYLMKSLQTSLFRRRLGTRAAF 338
+ ++ L +I S F + + R RAA
Sbjct 394 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAK 437
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 26/169 (15%), Positives = 55/169 (33%), Gaps = 22/169 (13%)
Query 433 YFDYLGNLIALANLVSICVFLV-------LDADVLPAERDDFILGILNCVFIVYYLLEML 485
F Y+ ++++ V V ++ ER L+ ++ + +E L
Sbjct 186 VFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
L++ A R V V+ I + + G +S +T
Sbjct 246 LRLAAAPSRYRF-------------VRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT- 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + VFR + + + ++ T+ + L + +FA
Sbjct 292 -LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
>sp|P48547|KCNC1_HUMAN Voltage-gated potassium channel KCNC1 OS=Homo
sapiens OX=9606 GN=KCNC1 PE=1 SV=1
Length=511
Score = 50.1 bits (118), Expect = 6e-05, Method: Composition-based stats.
Identities = 36/216 (17%), Positives = 73/216 (34%), Gaps = 21/216 (10%)
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVK-GYLFGWAHFQKNLWLLGYLV------- 163
+ R +E +C++ F + ++ + F KN + V
Sbjct 232 QVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYL 291
Query 164 -VLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLL 222
V + L L +R R+LR F L ++ ++ +R S E + +
Sbjct 292 EVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF 351
Query 223 LAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY 282
LA+ + +F G Q + T+F+N+P +V +TT D+ +
Sbjct 352 LALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTW 411
Query 283 SKNRAYAI------------FFIVFTVIGSLFLMNL 306
S A+ ++ G + + +
Sbjct 412 SGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Score = 40.1 bits (92), Expect = 0.077, Method: Composition-based stats.
Identities = 57/394 (14%), Positives = 112/394 (28%), Gaps = 72/394 (18%)
Query 333 GTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
A + + + V + L LD+S A + G
Sbjct 89 EELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDE 148
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF 452
E ++ L S + P ++ + LF Y +A A+L I V
Sbjct 149 LEMTKR----LALSDSPDGRPGGFWRRWQPR-IWALFEDPYSSRYARYVAFASLFFILVS 203
Query 453 L---VLDAD----------------------VLPAERDDFILGILNCVFIVYYLLEMLLK 487
+ L+ + L + V +V++ E L++
Sbjct 204 ITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMR 263
Query 488 VFALGLR-GYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
V + ++ N+ D + ++ LE+ +
Sbjct 264 VIFCPNKVEFIKNSLNIIDF-VAILPFYLEVGLSGLSSKAAKDVLG-------------F 309
Query 547 LNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG 603
L ++ R LRI + + V+ T+ L + +FA + +
Sbjct 310 LRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFAT--MIYYAE 367
Query 604 VIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR 663
I A P + S + F A+VT M +
Sbjct 368 RIGAQPNDPSASEHTHFKNIPIG------------FWWAVVT----MTTLGYGDM----- 406
Query 664 RYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
Y WS + ++ V+ + + + +I+ NF
Sbjct 407 -YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 439
>sp|Q63881|KCND2_RAT A-type voltage-gated potassium channel KCND2
OS=Rattus norvegicus OX=10116 GN=Kcnd2 PE=1 SV=1
Length=630
Score = 50.5 bits (119), Expect = 6e-05, Method: Composition-based stats.
Identities = 30/224 (13%), Positives = 85/224 (38%), Gaps = 29/224 (13%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-------V 179
++ C+++F + ++ + ++ ++ ++ VV+++ + + L +
Sbjct 231 CLDTACVMIFTVEYLLRLAA-APSRYRFVRSVMS--IIDVVAILPYYIGLVMTDNEDVSG 287
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR+ R+ R F ++S ++ ++ E+ + L + + +F ++ +A
Sbjct 288 AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA 345
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ + F ++P + +V +TT D++ + +I +
Sbjct 346 -------EKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSI-----CSLS 393
Query 300 SLFLMNLLTAIIYSQF-----RGYLMKSLQTSLFRRRLGTRAAF 338
+ ++ L +I S F + + R RAA
Sbjct 394 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAK 437
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 26/169 (15%), Positives = 55/169 (33%), Gaps = 22/169 (13%)
Query 433 YFDYLGNLIALANLVSICVFLV-------LDADVLPAERDDFILGILNCVFIVYYLLEML 485
F Y+ ++++ V V ++ ER L+ ++ + +E L
Sbjct 186 VFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
L++ A R V V+ I + + G +S +T
Sbjct 246 LRLAAAPSRYRF-------------VRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT- 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + VFR + + + ++ T+ + L + +FA
Sbjct 292 -LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
>sp|Q9NZV8|KCND2_HUMAN A-type voltage-gated potassium channel
KCND2 OS=Homo sapiens OX=9606 GN=KCND2 PE=1 SV=2
Length=630
Score = 50.5 bits (119), Expect = 6e-05, Method: Composition-based stats.
Identities = 30/224 (13%), Positives = 85/224 (38%), Gaps = 29/224 (13%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-------V 179
++ C+++F + ++ + ++ ++ ++ VV+++ + + L +
Sbjct 231 CLDTACVMIFTVEYLLRLAA-APSRYRFVRSVMS--IIDVVAILPYYIGLVMTDNEDVSG 287
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR+ R+ R F ++S ++ ++ E+ + L + + +F ++ +A
Sbjct 288 AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA 345
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ + F ++P + +V +TT D++ + +I +
Sbjct 346 -------EKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSI-----CSLS 393
Query 300 SLFLMNLLTAIIYSQF-----RGYLMKSLQTSLFRRRLGTRAAF 338
+ ++ L +I S F + + R RAA
Sbjct 394 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAK 437
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 26/169 (15%), Positives = 55/169 (33%), Gaps = 22/169 (13%)
Query 433 YFDYLGNLIALANLVSICVFLV-------LDADVLPAERDDFILGILNCVFIVYYLLEML 485
F Y+ ++++ V V ++ ER L+ ++ + +E L
Sbjct 186 VFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
L++ A R V V+ I + + G +S +T
Sbjct 246 LRLAAAPSRYRF-------------VRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT- 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + VFR + + + ++ T+ + L + +FA
Sbjct 292 -LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
>sp|O70344|KCNQ1_CAVPO Potassium voltage-gated channel subfamily
KQT member 1 OS=Cavia porcellus OX=10141 GN=KCNQ1 PE=2 SV=3
Length=671
Score = 50.5 bits (119), Expect = 6e-05, Method: Composition-based stats.
Identities = 34/202 (17%), Positives = 71/202 (35%), Gaps = 16/202 (8%)
Query 402 ELDRSVVKEHPPRPEYQSPFLQSAQFLF-----GHYYFDYLGNLIALANLVSICVFLVLD 456
LD V RP +Q + F G F Y + +++ +F VL
Sbjct 87 SLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVY--HFAVFLIVLACLIFSVLS 144
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
A L + V +V++ E ++++++ G R + ++
Sbjct 145 TIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDL 204
Query 517 ISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL--- 573
I +A + G + ++ + R + L + R L + ++ S V
Sbjct 205 IVVVASMVVLCVGSKGQVFATSA----IRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHR 260
Query 574 -GLVQNM-RAFGGILVVVYYVF 593
L+ + F G++ Y+V+
Sbjct 261 QELITTLYIGFLGLIFSSYFVY 282
Score = 40.5 bits (93), Expect = 0.070, Method: Composition-based stats.
Identities = 51/352 (14%), Positives = 108/352 (31%), Gaps = 41/352 (12%)
Query 88 FTIFLIL--FLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGY 145
F +FLI+ L F + A G +E++ ++ F + V+ +
Sbjct 128 FAVFLIVLACLIFSVLSTIEQYAA----------LATGTLFWMEIVLVVFFGTEYVVRLW 177
Query 146 LFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL--------SLVCHEPLRIR 187
G +W + L+V+V S+V V ++ L+I
Sbjct 178 SAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQIL 237
Query 188 RLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQ 247
R+L ++ + R L +G L I F + L + D
Sbjct 238 RMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF----VYL----AEKDAV 289
Query 248 DRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLL 307
+ F + ++L +V +TT D + + + F + +L L
Sbjct 290 NESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILG 349
Query 308 TAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQ 367
+ + K + + A+ ++ + + V ++ +
Sbjct 350 SGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSP 409
Query 368 KVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQS 419
+ K AM+ K + +K+ + RP++ S
Sbjct 410 SPKP---KKSAMVRKKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFS 458
>sp|Q9Z0V2|KCND2_MOUSE A-type voltage-gated potassium channel
KCND2 OS=Mus musculus OX=10090 GN=Kcnd2 PE=1 SV=1
Length=630
Score = 50.1 bits (118), Expect = 6e-05, Method: Composition-based stats.
Identities = 30/224 (13%), Positives = 85/224 (38%), Gaps = 29/224 (13%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-------V 179
++ C+++F + ++ + ++ ++ ++ VV+++ + + L +
Sbjct 231 CLDTACVMIFTVEYLLRLAA-APSRYRFVRSVMS--IIDVVAILPYYIGLVMTDNEDVSG 287
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR+ R+ R F ++S ++ ++ E+ + L + + +F ++ +A
Sbjct 288 AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA 345
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ + F ++P + +V +TT D++ + +I +
Sbjct 346 -------EKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSI-----CSLS 393
Query 300 SLFLMNLLTAIIYSQF-----RGYLMKSLQTSLFRRRLGTRAAF 338
+ ++ L +I S F + + R RAA
Sbjct 394 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAK 437
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 26/169 (15%), Positives = 55/169 (33%), Gaps = 22/169 (13%)
Query 433 YFDYLGNLIALANLVSICVFLV-------LDADVLPAERDDFILGILNCVFIVYYLLEML 485
F Y+ ++++ V V ++ ER L+ ++ + +E L
Sbjct 186 VFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
L++ A R V V+ I + + G +S +T
Sbjct 246 LRLAAAPSRYRF-------------VRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT- 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + VFR + + + ++ T+ + L + +FA
Sbjct 292 -LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
>sp|P59995|KCND2_RABIT A-type voltage-gated potassium channel
KCND2 OS=Oryctolagus cuniculus OX=9986 GN=KCND2 PE=2 SV=1
Length=630
Score = 50.1 bits (118), Expect = 6e-05, Method: Composition-based stats.
Identities = 30/224 (13%), Positives = 85/224 (38%), Gaps = 29/224 (13%)
Query 127 SVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-------V 179
++ C+++F + ++ + ++ ++ ++ VV+++ + + L +
Sbjct 231 CLDTACVMIFTVEYLLRLAA-APSRYRFVRSVMS--IIDVVAILPYYIGLVMTDNEDVSG 287
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
LR+ R+ R F ++S ++ ++ E+ + L + + +F ++ +A
Sbjct 288 AFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFAT--VMFYA 345
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIG 299
+ + F ++P + +V +TT D++ + +I +
Sbjct 346 -------EKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSI-----CSLS 393
Query 300 SLFLMNLLTAIIYSQF-----RGYLMKSLQTSLFRRRLGTRAAF 338
+ ++ L +I S F + + R RAA
Sbjct 394 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAK 437
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 26/169 (15%), Positives = 55/169 (33%), Gaps = 22/169 (13%)
Query 433 YFDYLGNLIALANLVSICVFLV-------LDADVLPAERDDFILGILNCVFIVYYLLEML 485
F Y+ ++++ V V ++ ER L+ ++ + +E L
Sbjct 186 VFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYL 245
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
L++ A R V V+ I + + G +S +T
Sbjct 246 LRLAAAPSRYRF-------------VRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVT- 291
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
L + VFR + + + ++ T+ + L + +FA
Sbjct 292 -LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFA 339
>sp|Q3U2S8|HVCN1_MOUSE Voltage-gated hydrogen channel 1 OS=Mus
musculus OX=10090 GN=Hvcn1 PE=1 SV=2
Length=269
Score = 48.6 bits (114), Expect = 8e-05, Method: Composition-based stats.
Identities = 27/160 (17%), Positives = 65/160 (41%), Gaps = 4/160 (3%)
Query 415 PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI---LGI 471
P F + LF + F + + + + + + L+LD ++ + D+
Sbjct 78 PRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHY 137
Query 472 LNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWR 531
++ +V+++LE+ K+F L + + + D + VV VL++ L
Sbjct 138 MSFAILVFFMLEIFFKIFVFRLE-FFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGL 196
Query 532 PEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVAST 571
++ L + + + + + R R I +K + + +T
Sbjct 197 LILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLAT 236
>sp|P97414|KCNQ1_MOUSE Potassium voltage-gated channel subfamily
KQT member 1 OS=Mus musculus OX=10090 GN=Kcnq1 PE=1 SV=3
Length=668
Score = 49.7 bits (117), Expect = 9e-05, Method: Composition-based stats.
Identities = 38/212 (18%), Positives = 75/212 (35%), Gaps = 16/212 (8%)
Query 392 SAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF-----GHYYFDYLGNLIALANL 446
A+ + LD V RP +Q + F G F Y + L L
Sbjct 75 PADLGPRPRVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVY-HFTVFLIVL 133
Query 447 VSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDG 506
V + +F VL A L + V +V++ E ++++++ G R
Sbjct 134 VCL-IFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 192
Query 507 LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
+ ++ I +A + G + ++ + R + L + R L +
Sbjct 193 ARKPISIIDLIVVVASMVVLCVGSKGQVFATSA----IRGIRFLQILRMLHVDRQGGTWR 248
Query 567 VVASTVL----GLVQNM-RAFGGILVVVYYVF 593
++ S V L+ + F G++ Y+V+
Sbjct 249 LLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 280
Score = 39.7 bits (91), Expect = 0.11, Method: Composition-based stats.
Identities = 44/261 (17%), Positives = 90/261 (34%), Gaps = 42/261 (16%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST +Y A G +E++
Sbjct 108 RVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTI-EQYAAL----ATGTLFWMEIVL 162
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + V+ + G +W + L+V+V S+V V
Sbjct 163 VVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFA 222
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 223 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 278
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSKNRAYAIF 291
+ L + D + F + ++L +V +TT D + + +++F
Sbjct 279 VYL----AEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 334
Query 292 FIVFT-----VIGSLFLMNLL 307
I F ++GS F + +
Sbjct 335 AISFFALPAGILGSGFALKVQ 355
>sp|Q9N0B5|TM266_MACFA Transmembrane protein 266 OS=Macaca fascicularis
OX=9541 GN=TMEM266 PE=2 SV=3
Length=531
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 24/114 (21%), Positives = 52/114 (46%), Gaps = 5/114 (4%)
Query 439 NLIALANLVSICVFLVLDADV-----LPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
L+A LV I + L L D+ A + ++ ++ V + + E +L++ LG+
Sbjct 103 FLVACVILVVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGI 162
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
Y+ VFDG + ++ L +++ P ++ +L +W + R++
Sbjct 163 WDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVI 216
>sp|P70057|KCNQ1_XENLA Potassium voltage-gated channel subfamily
KQT member 1 OS=Xenopus laevis OX=8355 GN=kcnq1 PE=1 SV=2
Length=652
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 29/235 (12%), Positives = 77/235 (33%), Gaps = 16/235 (7%)
Query 364 QVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQ 423
Q + Q +S + ++ + +++ R ++ + + +
Sbjct 48 QRQEDRQANSFELKRETLVATDPPRPTINLDPRVSIYSG-RRPLLSRTNIQGRVYNFLER 106
Query 424 SAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE 483
+ Y+F ++ +F VL L + V +V++ E
Sbjct 107 PTGWKCFVYHFTVFLIVLICL------IFSVLSTIQQYNNLATETLFWMEIVLVVFFGAE 160
Query 484 MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDM 543
++++++ G R + ++ I +A + G ++ +
Sbjct 161 YVVRLWSAGCRSKYVGVWGRLRFARKPISVIDLIVVVASVIVLCVGSNGQVFATSA---- 216
Query 544 TRMLNMLIVFRFLRIIPSMKLMAVVASTVL----GLVQNM-RAFGGILVVVYYVF 593
R + L + R L + ++ S V L+ + F G++ Y+V+
Sbjct 217 IRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 271
Score = 43.9 bits (102), Expect = 0.005, Method: Composition-based stats.
Identities = 52/376 (14%), Positives = 116/376 (31%), Gaps = 36/376 (10%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + I S+ ST +E++
Sbjct 99 RVYNFLERPTGWKCFVYHFTVFLIVLICLIFSVLSTI-----QQYNNLATETLFWMEIVL 153
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSLS----- 177
++ F A+ V+ + G +W + L+V+V S++ V +
Sbjct 154 VVFFGAEYVVRLWSAGCRSKYVGVWGRLRFARKPISVIDLIVVVASVIVLCVGSNGQVFA 213
Query 178 ---LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
+ L+I R+L ++ + R L +G L I F
Sbjct 214 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 269
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
+ L + D D F + ++L +V +TT D + + + F +
Sbjct 270 VYL----AEKDAIDSSGEYQFGSYADALWWGVVTVTTIGYGDKVPQTWIGKTIASCFSVF 325
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
+L L + + K + + A+ ++ + +
Sbjct 326 AISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSATWKIY 385
Query 355 VGVKPQN--LLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHP 412
+ + +N L+ K + + K+ + R GS ++ + +
Sbjct 386 IRKQSRNHHLMSPSPKPKKSAMVKKKKIRTERDEGSTDKMLNIPHITYDHVADDRKNDGY 445
Query 413 PRPEYQSPFLQSAQFL 428
Y++ + FL
Sbjct 446 SVESYENTVRKPFGFL 461
>sp|A0A1D5PXA5|TRPV4_CHICK Transient receptor potential cation
channel subfamily V member 4 OS=Gallus gallus OX=9031 GN=TRPV4
PE=1 SV=1
Length=852
Score = 49.3 bits (116), Expect = 1e-04, Method: Composition-based stats.
Identities = 51/329 (16%), Positives = 109/329 (33%), Gaps = 37/329 (11%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
E + L+ FG F A ++ + + P + L
Sbjct 439 EPINELLRDKWRKFGAVSFYISVVSYLCAMIIFTLIAYYRPMEGPPPYPYTTTIDYLRLA 498
Query 476 FIVYYLLEMLLKVFAL----------GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRL 525
+ LL +L F+ G+ + S LL + VL I T +Y
Sbjct 499 GEIITLLTGILFFFSNIKDLFMKKCPGVNSFFIDGSF---QLLYFIYSVLVIVTAGLYLG 555
Query 526 PHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI 585
+ MV L + L + ++ + L +++ F +
Sbjct 556 GVEAYLAVMVFAL-VLGWMNALYFTRGLKLTGTYSI--MIQKI------LFKDLFRFLLV 606
Query 586 LVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT 645
++ +A ++L + P + S + + + ++ F F L+
Sbjct 607 YLLFMIGYASALVSL----LNPCPSSESCSEDHSNCTLPTYPSCRDSQT-FSTF---LLD 658
Query 646 LWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRS 705
L+ L + L++ +Y G + I V + +++ V+ +N+ +AL+ E
Sbjct 659 LFKLTIGMGDLEMLES-AKYPGVF-IILLVTYIILTFVLLLNMLIALMGETVGQVSKESK 716
Query 706 HLQPLA-----GTPEATYQMTVELLFRDI 729
H+ L E ++ + + +FR
Sbjct 717 HIWKLQWATTILDIERSFPLFLRRVFRSG 745
>sp|Q2M3C6|TM266_HUMAN Transmembrane protein 266 OS=Homo sapiens
OX=9606 GN=TMEM266 PE=1 SV=2
Length=531
Score = 49.0 bits (115), Expect = 1e-04, Method: Composition-based stats.
Identities = 24/114 (21%), Positives = 52/114 (46%), Gaps = 5/114 (4%)
Query 439 NLIALANLVSICVFLVLDADV-----LPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
L+A LV I + L L D+ A + ++ ++ V + + E +L++ LG+
Sbjct 103 FLVACVILVVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGI 162
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML 547
Y+ VFDG + ++ L +++ P ++ +L +W + R++
Sbjct 163 WDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVI 216
>sp|Q9Z0N7|KCNQ1_RAT Potassium voltage-gated channel subfamily
KQT member 1 OS=Rattus norvegicus OX=10116 GN=Kcnq1 PE=1 SV=1
Length=669
Score = 49.0 bits (115), Expect = 1e-04, Method: Composition-based stats.
Identities = 37/202 (18%), Positives = 72/202 (36%), Gaps = 16/202 (8%)
Query 402 ELDRSVVKEHPPRPEYQSPFLQSAQFLF-----GHYYFDYLGNLIALANLVSICVFLVLD 456
LD V RP +Q + F G F Y + L LV + +F VL
Sbjct 86 SLDPRVSIYSTRRPLLARTHIQGRVYNFLERPTGWKCFVY-HFTVFLIVLVCL-IFSVLS 143
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
A L + V +V++ E ++++++ G R + ++
Sbjct 144 TIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDL 203
Query 517 ISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL--- 573
I +A + G + ++ + R + L + R L + ++ S V
Sbjct 204 IVVVASMVVLCVGSKGQVFATSA----IRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHR 259
Query 574 -GLVQNM-RAFGGILVVVYYVF 593
L+ + F G++ Y+V+
Sbjct 260 QELITTLYIGFLGLIFSSYFVY 281
Score = 39.3 bits (90), Expect = 0.14, Method: Composition-based stats.
Identities = 44/261 (17%), Positives = 90/261 (34%), Gaps = 42/261 (16%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST +Y A G +E++
Sbjct 109 RVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTI-EQYAAL----ATGTLFWMEIVL 163
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + V+ + G +W + L+V+V S+V V
Sbjct 164 VVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFA 223
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 224 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 279
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSKNRAYAIF 291
+ L + D + F + ++L +V +TT D + + +++F
Sbjct 280 VYL----AEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 335
Query 292 FIVFT-----VIGSLFLMNLL 307
I F ++GS F + +
Sbjct 336 AISFFALPAGILGSGFALKVQ 356
>sp|O97531|KCNQ1_FELCA Potassium voltage-gated channel subfamily
KQT member 1 (Fragment) OS=Felis catus OX=9685 GN=KCNQ1 PE=2
SV=2
Length=582
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 34/190 (18%), Positives = 68/190 (36%), Gaps = 16/190 (8%)
Query 414 RPEYQSPFLQSAQFLF-----GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFI 468
RP +Q + F G F Y + L LV + +F VL
Sbjct 9 RPLLARTHIQGRVYNFLERPTGWKCFVY-HFAVFLIVLVCL-IFSVLSTIEQYVALATGT 66
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L + V +V++ E ++++++ G R + ++ I LA +
Sbjct 67 LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGVWGRLRFARKPISIIDLIVVLASMVVLCV 126
Query 529 GWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL----GLVQNM-RAFG 583
G + ++ + R + L + R L + ++ S V L+ + F
Sbjct 127 GSKGQVFATSA----IRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 182
Query 584 GILVVVYYVF 593
G++ Y+V+
Sbjct 183 GLIFSSYFVY 192
Score = 39.7 bits (91), Expect = 0.10, Method: Composition-based stats.
Identities = 43/301 (14%), Positives = 94/301 (31%), Gaps = 34/301 (11%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST + A G +E++
Sbjct 20 RVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYVALA-----TGTLFWMEIVL 74
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + V+ + G +W + L+V++ S+V V
Sbjct 75 VVFFGTEYVVRLWSAGCRSKYVGVWGRLRFARKPISIIDLIVVLASMVVLCVGSKGQVFA 134
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 135 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 190
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
+ L + D + F + ++L +V +TT D + + + F +
Sbjct 191 VYL----AEKDAVNESGQVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 246
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
+L L + + K + + A+ ++ E +
Sbjct 247 AISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPESSTWNIY 306
Query 355 V 355
V
Sbjct 307 V 307
>sp|P51787|KCNQ1_HUMAN Potassium voltage-gated channel subfamily
KQT member 1 OS=Homo sapiens OX=9606 GN=KCNQ1 PE=1 SV=3
Length=676
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 25/165 (15%), Positives = 58/165 (35%), Gaps = 15/165 (9%)
Query 434 FDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGL 493
F ++ +F VL A L + V +V++ E ++++++ G
Sbjct 127 FAVFLIVLVCL------IFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC 180
Query 494 RGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF 553
R + ++ I +A + G + ++ + R + L +
Sbjct 181 RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSA----IRGIRFLQIL 236
Query 554 RFLRIIPSMKLMAVVASTVL----GLVQNM-RAFGGILVVVYYVF 593
R L + ++ S V L+ + F G++ Y+V+
Sbjct 237 RMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 281
Score = 40.5 bits (93), Expect = 0.071, Method: Composition-based stats.
Identities = 45/305 (15%), Positives = 96/305 (31%), Gaps = 34/305 (11%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST +Y A G +E++
Sbjct 109 RVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTI-EQYAAL----ATGTLFWMEIVL 163
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + V+ + G LW + L+V+V S+V V
Sbjct 164 VVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFA 223
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 224 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 279
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV 294
+ L + D + F + ++L +V +TT D + + + F +
Sbjct 280 VYL----AEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 335
Query 295 FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQA 354
+L L + + K + + A+ ++ + +
Sbjct 336 AISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIY 395
Query 355 VGVKP 359
+ P
Sbjct 396 IRKAP 400
>sp|Q96PR1|KCNC2_HUMAN Voltage-gated potassium channel KCNC2 OS=Homo
sapiens OX=9606 GN=KCNC2 PE=1 SV=1
Length=638
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 70/203 (34%), Gaps = 21/203 (10%)
Query 125 TESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLV--------VLVVSLVDWTVS 175
VE +C++ F + V+ F KNL + V V + L
Sbjct 282 LTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAK 341
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
L +R R+LR F L ++ ++ +R S E + + LA+ + +F
Sbjct 342 DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIY 401
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI----- 290
G Q + T F+N+P +V +TT D+ +S A+
Sbjct 402 YAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAG 461
Query 291 -------FFIVFTVIGSLFLMNL 306
++ G + + +
Sbjct 462 VLTIAMPVPVIVNNFGMYYSLAM 484
Score = 42.4 bits (98), Expect = 0.016, Method: Composition-based stats.
Identities = 52/348 (15%), Positives = 101/348 (29%), Gaps = 44/348 (13%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ-KLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ D+ + E G E+ K D + + +
Sbjct 156 YRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRM 215
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFL---VLDADVLPAERDDFILGILNCVFIVY-YL 481
LF Y IA A+L I V + L+ + ++N +V Y
Sbjct 216 WALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYE 275
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL---------VLEISTLAVYRLPHPGWRP 532
+E AL + F+ L+ +V +L I +
Sbjct 276 IETD---PALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGL 332
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVV 589
+ + D+ L ++ R LRI + + V+ T+ L +
Sbjct 333 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+FA + I + ++ F+ + F A+VT
Sbjct 393 VLIFATM--------IYYAERVGAQPNDPSASEHTQFKNIPIG------FWWAVVT---- 434
Query 650 MVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
M + Y WS + ++ V+ + + + +I+ NF
Sbjct 435 MTTLGYGDM------YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 476
>sp|Q63959|KCNC3_MOUSE Voltage-gated potassium channel KCNC3 OS=Mus
musculus OX=10090 GN=Kcnc3 PE=1 SV=3
Length=769
Score = 49.0 bits (115), Expect = 2e-04, Method: Composition-based stats.
Identities = 44/283 (16%), Positives = 87/283 (31%), Gaps = 50/283 (18%)
Query 74 YRRYY-------------SNVCQRTLSFTIFLILFLA----------FIETPSSLTSTAD 110
+ R + S + ++F IL FI + + A
Sbjct 269 WWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQAS 328
Query 111 VRYRAAPWE------PPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ--KNLWLLGYL 162
A P VE +C++ F + ++ +L ++ +
Sbjct 329 PIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCV 388
Query 163 VVL-------VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+L + L L +R R+LR F L ++ ++ +R S E
Sbjct 389 AILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 448
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+ + LA+ + +F G D TYF+N+P +V +TT
Sbjct 449 FLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYG 508
Query 276 DVMIPAYSKNRAYAI------------FFIVFTVIGSLFLMNL 306
D+ +S A+ ++ G + + +
Sbjct 509 DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 551
>sp|P22462|KCNC2_RAT Voltage-gated potassium channel KCNC2 OS=Rattus
norvegicus OX=10116 GN=Kcnc2 PE=1 SV=1
Length=638
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 70/203 (34%), Gaps = 21/203 (10%)
Query 125 TESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLV--------VLVVSLVDWTVS 175
VE +C++ F + V+ F KNL + V V + L
Sbjct 282 LTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAK 341
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
L +R R+LR F L ++ ++ +R S E + + LA+ + +F
Sbjct 342 DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIY 401
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI----- 290
G Q + T F+N+P +V +TT D+ +S A+
Sbjct 402 YAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAG 461
Query 291 -------FFIVFTVIGSLFLMNL 306
++ G + + +
Sbjct 462 VLTIAMPVPVIVNNFGMYYSLAM 484
Score = 40.9 bits (94), Expect = 0.044, Method: Composition-based stats.
Identities = 52/348 (15%), Positives = 100/348 (29%), Gaps = 44/348 (13%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEE-FQKLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ D+ + E G E+ K D + + +
Sbjct 156 YRQHRDAEEALDIFETPDLIGGDPGDDEDLGGKRLGIEDAAGLGGPDGKSGRWRKLQPRM 215
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFL---VLDADVLPAERDDFILGILNCVFIVY-YL 481
LF Y IA A+L I V + L+ + ++N V Y
Sbjct 216 WALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYE 275
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL---------VLEISTLAVYRLPHPGWRP 532
+E AL + F+ L+ +V +L I +
Sbjct 276 IETD---PALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGL 332
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVV 589
+ + D+ L ++ R LRI + + V+ T+ L +
Sbjct 333 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 392
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+FA + I + ++ F+ + F A+VT
Sbjct 393 VLIFATM--------IYYAERVGAQPNDPSASEHTQFKNIPIG------FWWAVVT---- 434
Query 650 MVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
M + Y WS + ++ V+ + + + +I+ NF
Sbjct 435 MTTLGYGDM------YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 476
>sp|Q14B80|KCNC2_MOUSE Voltage-gated potassium channel KCNC2 OS=Mus
musculus OX=10090 GN=Kcnc2 PE=1 SV=1
Length=642
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 38/203 (19%), Positives = 70/203 (34%), Gaps = 21/203 (10%)
Query 125 TESVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLV--------VLVVSLVDWTVS 175
VE +C++ F + V+ F KNL + V V + L
Sbjct 286 LTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAK 345
Query 176 LSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGM 235
L +R R+LR F L ++ ++ +R S E + + LA+ + +F
Sbjct 346 DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIY 405
Query 236 LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI----- 290
G Q + T F+N+P +V +TT D+ +S A+
Sbjct 406 YAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAG 465
Query 291 -------FFIVFTVIGSLFLMNL 306
++ G + + +
Sbjct 466 VLTIAMPVPVIVNNFGMYYSLAM 488
Score = 40.5 bits (93), Expect = 0.068, Method: Composition-based stats.
Identities = 52/348 (15%), Positives = 100/348 (29%), Gaps = 44/348 (13%)
Query 367 QKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQ-KLFNELDRSVVKEHPPRPEYQSPFLQSA 425
+ D+ + E G E+ K D + + +
Sbjct 160 YRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRKLQPRM 219
Query 426 QFLFGHYYFDYLGNLIALANLVSICVFL---VLDADVLPAERDDFILGILNCVFIVY-YL 481
LF Y IA A+L I V + L+ + ++N V Y
Sbjct 220 WALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSPVLQYE 279
Query 482 LEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL---------VLEISTLAVYRLPHPGWRP 532
+E AL + F+ L+ +V +L I +
Sbjct 280 IETD---PALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGL 336
Query 533 EMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVV 589
+ + D+ L ++ R LRI + + V+ T+ L +
Sbjct 337 SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 396
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL 649
+FA + I + ++ F+ + F A+VT
Sbjct 397 VLIFATM--------IYYAERVGAQPNDPSASEHTQFKNIPIG------FWWAVVT---- 438
Query 650 MVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENF 697
M + Y WS + ++ V+ + + + +I+ NF
Sbjct 439 MTTLGYGDM------YPQTWSGMLVGALCALAGVLTIAMPVPVIVNNF 480
>sp|Q9TTJ7|KCNQ1_PIG Potassium voltage-gated channel subfamily
KQT member 1 OS=Sus scrofa OX=9823 GN=KCNQ1 PE=2 SV=2
Length=673
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 36/202 (18%), Positives = 70/202 (35%), Gaps = 16/202 (8%)
Query 402 ELDRSVVKEHPPRPEYQSPFLQSAQFLF-----GHYYFDYLGNLIALANLVSICVFLVLD 456
LD V RP +Q + F G F Y + L LV + +F VL
Sbjct 84 SLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVY-HFAVFLIVLVCL-IFSVLS 141
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
L + V +V++ E +++++ G R + ++
Sbjct 142 TIEQYVALATGTLFWMEIVLVVFFGTEYAVRLWSAGCRSKYVGIWGRLRFARKPISIIDL 201
Query 517 ISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL--- 573
I +A + G + ++ + R + L + R L + ++ S V
Sbjct 202 IVVVASMVVLCVGSKGQVFATSA----IRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHR 257
Query 574 -GLVQNM-RAFGGILVVVYYVF 593
L+ + F G++ Y+V+
Sbjct 258 QELITTLYIGFLGLIFSSYFVY 279
Score = 38.6 bits (88), Expect = 0.23, Method: Composition-based stats.
Identities = 43/261 (16%), Positives = 90/261 (34%), Gaps = 42/261 (16%)
Query 76 RYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
R Y+ + + F + + + S+ ST + A G +E++
Sbjct 107 RVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYVALA-----TGTLFWMEIVL 161
Query 133 LLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVSL------ 176
++ F + +V+ + G +W + L+V+V S+V V
Sbjct 162 VVFFGTEYAVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFA 221
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
++ L+I R+L ++ + R L +G L I F
Sbjct 222 TSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYF---- 277
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM---IPAYSKNRAYAIF 291
+ L + D + F + ++L +V +TT D + + +++F
Sbjct 278 VYL----AEKDAVNESGQVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVF 333
Query 292 FIVFT-----VIGSLFLMNLL 307
I F ++GS F + +
Sbjct 334 AISFFALPAGILGSGFALKVQ 354
>sp|Q14003|KCNC3_HUMAN Voltage-gated potassium channel KCNC3 OS=Homo
sapiens OX=9606 GN=KCNC3 PE=1 SV=3
Length=757
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 44/283 (16%), Positives = 87/283 (31%), Gaps = 50/283 (18%)
Query 74 YRRYY-------------SNVCQRTLSFTIFLILFLA----------FIETPSSLTSTAD 110
+ R + S + ++F IL FI + + A
Sbjct 268 WWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQAS 327
Query 111 VRYRAAPWE------PPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ--KNLWLLGYL 162
A P VE +C++ F + ++ +L ++ +
Sbjct 328 PIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCV 387
Query 163 VVL-------VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+L + L L +R R+LR F L ++ ++ +R S E
Sbjct 388 AILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 447
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+ + LA+ + +F G D TYF+N+P +V +TT
Sbjct 448 FLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYG 507
Query 276 DVMIPAYSKNRAYAI------------FFIVFTVIGSLFLMNL 306
D+ +S A+ ++ G + + +
Sbjct 508 DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 550
>sp|O73925|KCNQ1_SQUAC Potassium voltage-gated channel subfamily
KQT member 1 OS=Squalus acanthias OX=7797 GN=KCNQ1 PE=2 SV=1
Length=660
Score = 48.6 bits (114), Expect = 2e-04, Method: Composition-based stats.
Identities = 24/167 (14%), Positives = 60/167 (36%), Gaps = 13/167 (8%)
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
+ + + LI L L+ + + + L + V +V++ E ++++++
Sbjct 116 FIYHFTVFLIVLVCLIFSVMSTIEQYHYFA----NRALVWMEIVLVVFFGTEYIVRLWSA 171
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
G R + ++ I +A + G ++ + R + L
Sbjct 172 GCRSKYVGFWGRLRFARKPISIIDLIVVVASVIVLCVGSNGQVFATSA----IRGIRFLQ 227
Query 552 VFRFLRIIPSMKLMAVVASTVL----GLVQNM-RAFGGILVVVYYVF 593
+ R L + ++ S V L+ + F G++ Y+V+
Sbjct 228 ILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 274
Score = 43.9 bits (102), Expect = 0.006, Method: Composition-based stats.
Identities = 44/260 (17%), Positives = 86/260 (33%), Gaps = 35/260 (13%)
Query 69 SSMWLYRRYYSNVCQ---RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLT 125
S + + R Y+ + + F + + + S+ ST + + A
Sbjct 95 SKVNIQGRTYNFLERPTGWKCFIYHFTVFLIVLVCLIFSVMSTIEQYHYFANRA-----L 149
Query 126 ESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW----------LLGYLVVLVVSLVDWTVS 175
+E++ ++ F + V+ + G W + L+V+V S++ V
Sbjct 150 VWMEIVLVVFFGTEYIVRLWSAGCRSKYVGFWGRLRFARKPISIIDLIVVVASVIVLCVG 209
Query 176 LS--------LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHL 227
+ + L+I R+L ++ + R L +G L I
Sbjct 210 SNGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFS 269
Query 228 CLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
F + L + D D F + ++L +V +TT D +P R
Sbjct 270 SYF----VYL----AEKDAVDDSGSQQFGSYADALWWGVVTVTTIGYGD-KVPQTWIGRT 320
Query 288 YAIFFIVFTVIGSLFLMNLL 307
A F VF + +L
Sbjct 321 IASCFSVFAISFFALPAGIL 340
>sp|Q01956|KCNC3_RAT Voltage-gated potassium channel KCNC3 OS=Rattus
norvegicus OX=10116 GN=Kcnc3 PE=1 SV=1
Length=889
Score = 48.2 bits (113), Expect = 3e-04, Method: Composition-based stats.
Identities = 44/283 (16%), Positives = 87/283 (31%), Gaps = 50/283 (18%)
Query 74 YRRYY-------------SNVCQRTLSFTIFLILFLA----------FIETPSSLTSTAD 110
+ R + S + ++F IL FI + + A
Sbjct 269 WWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQAS 328
Query 111 VRYRAAPWE------PPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ--KNLWLLGYL 162
A P VE +C++ F + ++ +L ++ +
Sbjct 329 PIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCV 388
Query 163 VVL-------VVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPE 215
+L + L L +R R+LR F L ++ ++ +R S E
Sbjct 389 AILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 448
Query 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
+ + LA+ + +F G D TYF+N+P +V +TT
Sbjct 449 FLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYG 508
Query 276 DVMIPAYSKNRAYAI------------FFIVFTVIGSLFLMNL 306
D+ +S A+ ++ G + + +
Sbjct 509 DMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 551
>sp|Q9HBA0|TRPV4_HUMAN Transient receptor potential cation channel
subfamily V member 4 OS=Homo sapiens OX=9606 GN=TRPV4 PE=1
SV=2
Length=871
Score = 47.8 bits (112), Expect = 4e-04, Method: Composition-based stats.
Identities = 35/246 (14%), Positives = 74/246 (30%), Gaps = 20/246 (8%)
Query 507 LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
LL + VL I + A+Y + MV L + L + ++
Sbjct 551 LLYFIYSVLVIVSAALYLAGIEAYLAVMVFAL-VLGWMNALYFTRGLKLTGTYSI--MIQ 607
Query 567 VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
+ L +++ F + ++ +A ++L N
Sbjct 608 KI------LFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCR 661
Query 627 EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWV 686
+ F F L+ L+ L + L + + I V + +++ V+ +
Sbjct 662 DSE-----TFSTF---LLDLFKLTIGMGDLEMLSSTKY--PVVFIILLVTYIILTFVLLL 711
Query 687 NLFLALILENFLHKWDPRSHLQPLA-GTPEATYQMTVELLFRDILEEPGEDELTERLSQH 745
N+ +AL+ E H+ L T + + + R + +
Sbjct 712 NMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGT 771
Query 746 PHLWLC 751
P C
Sbjct 772 PDRRWC 777
>sp|O73606|KCNG2_CHICK Voltage-gated potassium channel regulatory
subunit KCNG2 OS=Gallus gallus OX=9031 GN=KCNG2 PE=2 SV=1
Length=518
Score = 47.4 bits (111), Expect = 4e-04, Method: Composition-based stats.
Identities = 34/218 (16%), Positives = 71/218 (33%), Gaps = 14/218 (6%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGI 471
+++ F + VS+C+ + + D + + + +
Sbjct 201 RNLRDMVENPHSGIPGKIFACISISFVAITAVSLCISTMPDVREEEDRGECSQKCYDIFV 260
Query 472 LNCVFIVYYLLEMLLK-VFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY-RLPHPG 529
L V + ++ E LL+ + A +L P N+ D L + + I +A PG
Sbjct 261 LETVCVAWFSFEFLLRSIQAENKCAFLKTPLNIIDILAILPFYISLIVDMASTKNSSKPG 320
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVV 589
L + + R L L + +R+ + + TV + G+L++
Sbjct 321 GGAGNKYLERVGLVLRFLRALRILYVMRLARHSLGLQTLGLTV----RRCTREFGLLLLF 376
Query 590 YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFE 627
V + LF ++ S P +
Sbjct 377 LCV----AMALFSPLVYLAESELGAKQEFTSIPTSYWW 410
Score = 33.5 bits (75), Expect = 8.3, Method: Composition-based stats.
Identities = 39/287 (14%), Positives = 92/287 (32%), Gaps = 42/287 (15%)
Query 83 QRTLSFTIFLILFLAFIETPSSLTSTAD-VRYRAAPWEPPCG----LTESVEVLCLLVFA 137
+ IF + ++F+ + + R C +E +C+ F+
Sbjct 211 HSGIPGKIFACISISFVAITAVSLCISTMPDVREEEDRGECSQKCYDIFVLETVCVAWFS 270
Query 138 ADLSVKGY-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS------------------- 177
+ ++ F K + ++ ++ + V ++
Sbjct 271 FEFLLRSIQAENKCAFLKTPLNIIDILAILPFYISLIVDMASTKNSSKPGGGAGNKYLER 330
Query 178 -LVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGML 236
+ LR R+L L ++S ++ +R E LL + LC+ M
Sbjct 331 VGLVLRFLRALRILYVMRLARHSLGLQTLGLTVRRCTREFG----LLLLFLCV----AMA 382
Query 237 LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFT 296
LF+ + F ++P S ++ +TT D++ + + +
Sbjct 383 LFSPLVYLAESELGAKQEFTSIPTSYWWAVISMTTVGYGDMVPRSIPGQ-----VVALSS 437
Query 297 VIGSLFLMNLLTAIIYSQFR---GYLMKSLQTSLFRRRLGTRAAFEV 340
++ + LM I+ F L + Q + R+ + ++
Sbjct 438 ILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASRQMHQLEESTKL 484
>sp|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel
protein painless OS=Drosophila melanogaster OX=7227 GN=pain
PE=1 SV=1
Length=913
Score = 47.8 bits (112), Expect = 4e-04, Method: Composition-based stats.
Identities = 37/284 (13%), Positives = 100/284 (35%), Gaps = 30/284 (11%)
Query 415 PEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC 474
P S L +Y ++L + A++++ + ++D +L L
Sbjct 478 PLISSFLFLKWHRLSVIFYLNFLIYSLFTASIITYTLLKFHESDQRALTAFFGLLSWLGI 537
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
+++ E + + + Y +N ++ + + TL+++ + E
Sbjct 538 SYLIL--RECIQWIMS--PVRYFWSITN---------IMEVALITLSIFTCMESSFDKET 584
Query 535 VGLLSLWDM----TRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
+L+++ + ++ L I M ++ V+++ L F + +
Sbjct 585 QRVLAVFTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCF 644
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLM 650
Y+ LF + S+ G E+ + N F A++ ++
Sbjct 645 YI-------LFGKSVEEDQSKSATPCPPLGKKEGKDEEQGF--NTFTKPIEAVIKTIVML 695
Query 651 VVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
F +++ ++ + F+L+ + +++ NL L +
Sbjct 696 TGE----FDAGSIQFTSIYTYLIFLLFVIFMTIVLFNLLNGLAV 735
>sp|Q9U1S7|PKD2_CAEEL Polycystin-2 OS=Caenorhabditis elegans OX=6239
GN=pkd-2 PE=1 SV=3
Length=716
Score = 46.6 bits (109), Expect = 8e-04, Method: Composition-based stats.
Identities = 41/260 (16%), Positives = 92/260 (35%), Gaps = 49/260 (19%)
Query 455 LDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR--GYLSYPSNVFDGLLTVVL 512
L I + C FI+Y++ E ++FA+G YL+ N+ D +L
Sbjct 312 LLTYQTSGGTRMMIFEGIFCGFILYFIFE---ELFAIGRHRLHYLTQFWNLVDVVLLGFS 368
Query 513 L-------------VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRII 559
+ V ++++ L + + S ++ + + + + I
Sbjct 369 VATIILSVNRTKTGVNRVNSVIENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFI 428
Query 560 PSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANG 619
K M+ ++ST+ +++ G V G
Sbjct 429 SVNKTMSQLSSTLTRSAKDI----------------------GGFAVMFAVFFFAFAQFG 466
Query 620 SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWL 679
G+ ++ + + L L++ + L++ R+ GP +F+ +
Sbjct 467 YLCFGTQIA------DYSNLYNSAFALLRLILGDFNFSALESCNRFFGP---AFFIAYVF 517
Query 680 VSSVIWVNLFLALILENFLH 699
S I +N+FLA+I ++++
Sbjct 518 FVSFILLNMFLAIINDSYVE 537
Score = 35.5 bits (80), Expect = 2.2, Method: Composition-based stats.
Identities = 45/370 (12%), Positives = 101/370 (27%), Gaps = 64/370 (17%)
Query 87 SFTIFLILFLAFIETPS------SLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADL 140
+ +F ++ L F S T D+ + E + +L F +
Sbjct 282 NINLFCVVKLLFELPASGGVITTPKLMTYDLLTYQTSGGTRMMIFEGIFCGFILYFIFEE 341
Query 141 SVKGYLFGWA--HFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQN 198
+ G H+ W L +V+L S+ +S++ R+ ++
Sbjct 342 L---FAIGRHRLHYLTQFWNLVDVVLLGFSVATIILSVNRTKTGVNRVNSVIE------- 391
Query 199 SSMMKKT-LKCIRWSLPEMASVGL-LLAIHLC-LFTMFGMLLFAGGKQDDGQDRER---- 251
+ + + S ++ ++ + +F + +
Sbjct 392 -NGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGG 450
Query 252 -----------------------LTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAY 288
+ + NL S +LL L+ N +
Sbjct 451 FAVMFAVFFFAFAQFGYLCFGTQIADYSNLYNSAFALLRLILGDFNFSALESC--NRFFG 508
Query 289 AIFFIVFTVIGSLFLMNLLTAIIYSQF-------------RGYLMKSLQTSLFRRRLGTR 335
FFI + S L+N+ AII + G L + + G R
Sbjct 509 PAFFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKDGEGILDWFMNKVRGLTKRGKR 568
Query 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
+ + G +++ + + + S + + + E
Sbjct 569 PDAPGEDATYEDYKLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIADEVARMTE 628
Query 396 FQKLFNELDR 405
++ + E R
Sbjct 629 QKRNYMENHR 638
>sp|Q03721|KCNC4_HUMAN Voltage-gated potassium channel KCNC4 OS=Homo
sapiens OX=9606 GN=KCNC4 PE=1 SV=2
Length=635
Score = 46.3 bits (108), Expect = 0.001, Method: Composition-based stats.
Identities = 40/220 (18%), Positives = 74/220 (34%), Gaps = 23/220 (10%)
Query 108 TADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAH-FQKNLWLLGYLV--- 163
V +R P + +E +C+L F + V+ F KNL + V
Sbjct 266 ITSVHFRREVETEP--ILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAIL 323
Query 164 -----VLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMAS 218
V + L L +R R+LR F L ++ ++ +R S E
Sbjct 324 PFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL 383
Query 219 VGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
+ + LA+ + +F G + T F+N+P +V +TT D+
Sbjct 384 LIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMY 443
Query 279 IPAYSKNRAYAI------------FFIVFTVIGSLFLMNL 306
+S A+ ++ G + + +
Sbjct 444 PKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 483
Score = 43.6 bits (101), Expect = 0.007, Method: Composition-based stats.
Identities = 55/388 (14%), Positives = 108/388 (28%), Gaps = 71/388 (18%)
Query 344 MVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNEL 403
+ E F + + + D+ + E GS ++E EL
Sbjct 125 LFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDEREL 184
Query 404 DRSVVKEHPPRPEYQ------SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL---V 454
+ H + + LF Y ++A A+L I V +
Sbjct 185 ALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFC 244
Query 455 LDADV----------------------LPAERDDFILGILNCVFIVYYLLEMLLKVFALG 492
L+ + IL + V ++++ LE L+++
Sbjct 245 LETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIV--- 301
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
D L V +L I + + + D+ L ++
Sbjct 302 ---------CCPDTL-DFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRF 351
Query 553 FRFLRIIPSMK---LMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
R LRI + + V+ T+ L + +FA + I
Sbjct 352 VRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM--------IYYAE 403
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
+ F+ + F A+VT M + Y W
Sbjct 404 RIGARPSDPRGNDHTDFKNIPIG------FWWAVVT----MTTLGYGDM------YPKTW 447
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENF 697
S + ++ V+ + + + +I+ NF
Sbjct 448 SGMLVGALCALAGVLTIAMPVPVIVNNF 475
>sp|Q9JK45|KCNQ5_MOUSE Potassium voltage-gated channel subfamily
KQT member 5 OS=Mus musculus OX=10090 GN=Kcnq5 PE=1 SV=2
Length=933
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 31/196 (16%), Positives = 67/196 (34%), Gaps = 12/196 (6%)
Query 405 RSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
R VK + + + + F ++ F L+ L+ + + L +
Sbjct 104 RRNVKYRRVQNYLYNVLERPRGWAFVYHAF---VFLLVFGCLILSVFSTIPEHTKLASS- 159
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
L IL V IV + LE ++++++ G ++ I +A
Sbjct 160 ---CLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 216
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ + + +L R L L + R +R+ ++ S V + +
Sbjct 217 VVSAKTQGNIFATSAL----RSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWY 272
Query 585 ILVVVYYVFAIIGINL 600
I +V +F+ + L
Sbjct 273 IGFLV-LIFSSFLVYL 287
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 25/169 (15%), Positives = 55/169 (33%), Gaps = 30/169 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
R ++ V + +F L L+ T T A +E + ++V
Sbjct 124 RGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLAS------------SCLLILEFVMIVV 171
Query 136 FAADLSVKGY----------LFGWAHFQKNLWLLGYLVVLVVSL--VDWTVSLSLVCHEP 183
F + ++ + G F + + + +VL+ S+ V ++
Sbjct 172 FGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSA 231
Query 184 LRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
LR R L+ +++ ++ + L +G L+ I
Sbjct 232 LRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIF 280
>sp|Q9QX29|TRPC5_MOUSE Short transient receptor potential channel
5 OS=Mus musculus OX=10090 GN=Trpc5 PE=1 SV=2
Length=975
Score = 45.9 bits (107), Expect = 0.001, Method: Composition-based stats.
Identities = 32/265 (12%), Positives = 92/265 (35%), Gaps = 27/265 (10%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ ++ + ++ D+ ++ + +++ ++ + +++ G Y+
Sbjct 375 LTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDW 434
Query 501 SNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+ D + + L L+I Y P EM + + ++ + LR
Sbjct 435 WNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNI--LSSLR 492
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+I + + + ++ ++ +++ ++ + G+ + A
Sbjct 493 LISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAID 548
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF----LDAYRRYSGPWSKIY 673
+ G + E N F L +L+ W VF L + +
Sbjct 549 EPNNCKGI--RCEKQNNAFSTLFETLQSLF-------WSVFGLLNLYVTNVKARHEFTEF 599
Query 674 -----FVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 600 VGATMFGTYNVISLVVLLNMLIAMM 624
Score = 37.4 bits (85), Expect = 0.55, Method: Composition-based stats.
Identities = 34/273 (12%), Positives = 86/273 (32%), Gaps = 49/273 (18%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ + T + FL + S D+ + PP + E + + +L F +
Sbjct 366 KFICHTASYLTFLFMLLLASQHIVRTDLHVQG----PPPTVVEWMILPWVLGFIWGEIKE 421
Query 144 GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS--------------------LVCHEP 183
+ G+ + + W L + + L ++ + L+
Sbjct 422 MWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEAL 481
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSL-PEMASVGLLLAIHLCLFTMF------GML 236
I +L L+ T L + + L + L ++ + G+
Sbjct 482 FAISNILSSLRLISLF-----TANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 536
Query 237 ---LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP-----DVMIPAYSKNRAY 288
+ + D + + + + ++L L + ++ + +
Sbjct 537 QLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEF 596
Query 289 AIF-----FIVFTVIGSLFLMNLLTAIIYSQFR 316
F F + VI + L+N+L A++ + ++
Sbjct 597 TEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQ 629
>sp|O62852|TRPC5_RABIT Short transient receptor potential channel
5 OS=Oryctolagus cuniculus OX=9986 GN=TRPC5 PE=2 SV=1
Length=974
Score = 45.9 bits (107), Expect = 0.002, Method: Composition-based stats.
Identities = 32/265 (12%), Positives = 92/265 (35%), Gaps = 27/265 (10%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ ++ + ++ D+ ++ + +++ ++ + +++ G Y+
Sbjct 375 LTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDW 434
Query 501 SNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+ D + + L L+I Y P EM + + ++ + LR
Sbjct 435 WNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNI--LSSLR 492
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+I + + + ++ ++ +++ ++ + G+ + A
Sbjct 493 LISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAID 548
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF----LDAYRRYSGPWSKIY 673
+ G + E N F L +L+ W VF L + +
Sbjct 549 EPNNCKGI--RCEKQNNAFSTLFETLQSLF-------WSVFGLLNLYVTNVKARHEFTEF 599
Query 674 -----FVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 600 VGATMFGTYNVISLVVLLNMLIAMM 624
Score = 37.4 bits (85), Expect = 0.62, Method: Composition-based stats.
Identities = 34/273 (12%), Positives = 86/273 (32%), Gaps = 49/273 (18%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ + T + FL + S D+ + PP + E + + +L F +
Sbjct 366 KFICHTASYLTFLFMLLLASQHIVRTDLHVQG----PPPTVVEWMILPWVLGFIWGEIKE 421
Query 144 GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS--------------------LVCHEP 183
+ G+ + + W L + + L ++ + L+
Sbjct 422 MWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEAL 481
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSL-PEMASVGLLLAIHLCLFTMF------GML 236
I +L L+ T L + + L + L ++ + G+
Sbjct 482 FAISNILSSLRLISLF-----TANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 536
Query 237 ---LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP-----DVMIPAYSKNRAY 288
+ + D + + + + ++L L + ++ + +
Sbjct 537 QLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEF 596
Query 289 AIF-----FIVFTVIGSLFLMNLLTAIIYSQFR 316
F F + VI + L+N+L A++ + ++
Sbjct 597 TEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQ 629
>sp|Q8R1C0|KCNC4_MOUSE Voltage-gated potassium channel KCNC4 OS=Mus
musculus OX=10090 GN=Kcnc4 PE=2 SV=1
Length=628
Score = 45.5 bits (106), Expect = 0.002, Method: Composition-based stats.
Identities = 36/204 (18%), Positives = 70/204 (34%), Gaps = 21/204 (10%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAH-FQKNLWLLGYLV--------VLVVSLVDWTV 174
+ +E +C++ F + V+ F KNL + V V + L
Sbjct 284 ILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAA 343
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L +R R+LR F L ++ ++ +R S E + + LA+ + +F
Sbjct 344 RDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 403
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI---- 290
G + T F+N+P +V +TT D+ +S A+
Sbjct 404 YYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALA 463
Query 291 --------FFIVFTVIGSLFLMNL 306
++ G + + +
Sbjct 464 GVLTIAMPVPVIVNNFGMYYSLAM 487
Score = 36.6 bits (83), Expect = 1.1, Method: Composition-based stats.
Identities = 45/307 (15%), Positives = 88/307 (29%), Gaps = 65/307 (21%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL---VLDADV---------------- 459
+ LF Y ++A A+L I V + L+
Sbjct 210 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGN 269
Query 460 ------LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ IL + V ++++ LE L+++ D L V
Sbjct 270 ITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIV------------CCPDTL-DFVKN 316
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK---LMAVVAS 570
+L I + + + D+ L ++ R LRI + + V+
Sbjct 317 LLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGH 376
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
T+ L + +FA + I + F+ +
Sbjct 377 TLRASTNEFLLLIIFLALGVLIFATM--------IYYAERIGARPSDPRGNDHTDFKNIP 428
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFL 690
F A+VT M + Y WS + ++ V+ + + +
Sbjct 429 IG------FWWAVVT----MTTLGYGDM------YPKTWSGMLVGALCALAGVLTIAMPV 472
Query 691 ALILENF 697
+I+ NF
Sbjct 473 PVIVNNF 479
>sp|Q63734|KCNC4_RAT Voltage-gated potassium channel KCNC4 OS=Rattus
norvegicus OX=10116 GN=Kcnc4 PE=1 SV=1
Length=625
Score = 45.5 bits (106), Expect = 0.002, Method: Composition-based stats.
Identities = 36/204 (18%), Positives = 70/204 (34%), Gaps = 21/204 (10%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAH-FQKNLWLLGYLV--------VLVVSLVDWTV 174
+ +E +C++ F + V+ F KNL + V V + L
Sbjct 281 ILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340
Query 175 SLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFG 234
L +R R+LR F L ++ ++ +R S E + + LA+ + +F
Sbjct 341 RDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400
Query 235 MLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAI---- 290
G + T F+N+P +V +TT D+ +S A+
Sbjct 401 YYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALA 460
Query 291 --------FFIVFTVIGSLFLMNL 306
++ G + + +
Sbjct 461 GVLTIAMPVPVIVNNFGMYYSLAM 484
Score = 36.6 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 45/307 (15%), Positives = 88/307 (29%), Gaps = 65/307 (21%)
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL---VLDADV---------------- 459
+ LF Y ++A A+L I V + L+
Sbjct 207 RGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGN 266
Query 460 ------LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ IL + V ++++ LE L+++ D L V
Sbjct 267 ITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIV------------CCPDTL-DFVKN 313
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMK---LMAVVAS 570
+L I + + + D+ L ++ R LRI + + V+
Sbjct 314 LLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGH 373
Query 571 TVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLE 630
T+ L + +FA + I + F+ +
Sbjct 374 TLRASTNEFLLLIIFLALGVLIFATM--------IYYAERIGARPSDPRGNDHTDFKNIP 425
Query 631 YWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFL 690
F A+VT M + Y WS + ++ V+ + + +
Sbjct 426 IG------FWWAVVT----MTTLGYGDM------YPKTWSGMLVGALCALAGVLTIAMPV 469
Query 691 ALILENF 697
+I+ NF
Sbjct 470 PVIVNNF 476
>sp|Q9UL62|TRPC5_HUMAN Short transient receptor potential channel
5 OS=Homo sapiens OX=9606 GN=TRPC5 PE=1 SV=1
Length=973
Score = 45.9 bits (107), Expect = 0.002, Method: Composition-based stats.
Identities = 32/265 (12%), Positives = 92/265 (35%), Gaps = 27/265 (10%)
Query 441 IALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYP 500
+ ++ + ++ D+ ++ + +++ ++ + +++ G Y+
Sbjct 375 LTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDW 434
Query 501 SNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLR 557
N+ D + + L L+I Y P EM + + ++ + LR
Sbjct 435 WNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNI--LSSLR 492
Query 558 IIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPA 617
+I + + + ++ ++ +++ ++ + G+ + A
Sbjct 493 LISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAID 548
Query 618 NGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVF----LDAYRRYSGPWSKIY 673
+ G + E N F L +L+ W VF L + +
Sbjct 549 EPNNCKGI--RCEKQNNAFSTLFETLQSLF-------WSVFGLLNLYVTNVKARHEFTEF 599
Query 674 -----FVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 600 VGATMFGTYNVISLVVLLNMLIAMM 624
Score = 37.4 bits (85), Expect = 0.67, Method: Composition-based stats.
Identities = 34/273 (12%), Positives = 86/273 (32%), Gaps = 49/273 (18%)
Query 84 RTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVK 143
+ + T + FL + S D+ + PP + E + + +L F +
Sbjct 366 KFICHTASYLTFLFMLLLASQHIVRTDLHVQG----PPPTVVEWMILPWVLGFIWGEIKE 421
Query 144 GYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLS--------------------LVCHEP 183
+ G+ + + W L + + L ++ + L+
Sbjct 422 MWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEAL 481
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSL-PEMASVGLLLAIHLCLFTMF------GML 236
I +L L+ T L + + L + L ++ + G+
Sbjct 482 FAISNILSSLRLISLF-----TANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 536
Query 237 ---LFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP-----DVMIPAYSKNRAY 288
+ + D + + + + ++L L + ++ + +
Sbjct 537 QLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEF 596
Query 289 AIF-----FIVFTVIGSLFLMNLLTAIIYSQFR 316
F F + VI + L+N+L A++ + ++
Sbjct 597 TEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQ 629
>sp|O35119|TRPC4_RAT Short transient receptor potential channel
4 OS=Rattus norvegicus OX=10116 GN=Trpc4 PE=1 SV=2
Length=977
Score = 45.9 bits (107), Expect = 0.002, Method: Composition-based stats.
Identities = 28/207 (14%), Positives = 72/207 (35%), Gaps = 16/207 (8%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
GL+ Y+ N+ D ++ + L L+I Y +P +M + + +
Sbjct 425 GLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA--LFA 482
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG--VIV 606
+ +F LR+I + + + ++ ++ +++ ++ + G +
Sbjct 483 IANIFSSLRLISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
+ G ++ L NL V N + A ++
Sbjct 539 FYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTN-----VKAQHEFT 593
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 594 DFVGATMFGTYNVISLVVLLNMLIAMM 620
>sp|Q9NR82|KCNQ5_HUMAN Potassium voltage-gated channel subfamily
KQT member 5 OS=Homo sapiens OX=9606 GN=KCNQ5 PE=1 SV=3
Length=932
Score = 45.9 bits (107), Expect = 0.002, Method: Composition-based stats.
Identities = 31/196 (16%), Positives = 67/196 (34%), Gaps = 12/196 (6%)
Query 405 RSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAER 464
R VK + + + + F ++ F L+ L+ + + L +
Sbjct 103 RRNVKYRRVQNYLYNVLERPRGWAFIYHAF---VFLLVFGCLILSVFSTIPEHTKLASS- 158
Query 465 DDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYR 524
L IL V IV + LE ++++++ G ++ I +A
Sbjct 159 ---CLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query 525 LPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG 584
+ + + +L R L L + R +R+ ++ S V + +
Sbjct 216 VVSAKTQGNIFATSAL----RSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWY 271
Query 585 ILVVVYYVFAIIGINL 600
I +V +F+ + L
Sbjct 272 IGFLV-LIFSSFLVYL 286
Score = 44.7 bits (104), Expect = 0.003, Method: Composition-based stats.
Identities = 24/169 (14%), Positives = 55/169 (33%), Gaps = 30/169 (18%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
R ++ + + +F L L+ T T A +E + ++V
Sbjct 123 RGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLAS------------SCLLILEFVMIVV 170
Query 136 FAADLSVKGY----------LFGWAHFQKNLWLLGYLVVLVVSL--VDWTVSLSLVCHEP 183
F + ++ + G F + + + +VL+ S+ V ++
Sbjct 171 FGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSA 230
Query 184 LRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIH 226
LR R L+ +++ ++ + L +G L+ I
Sbjct 231 LRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIF 279
>sp|Q9ERZ8|TRPV4_RAT Transient receptor potential cation channel
subfamily V member 4 OS=Rattus norvegicus OX=10116 GN=Trpv4
PE=1 SV=1
Length=871
Score = 45.9 bits (107), Expect = 0.002, Method: Composition-based stats.
Identities = 34/249 (14%), Positives = 78/249 (31%), Gaps = 26/249 (10%)
Query 507 LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
LL + VL + + A+Y + MV L + L + ++
Sbjct 551 LLYFIYSVLVVVSAALYLAGIEAYLAVMVFAL-VLGWMNALYFTRGLKLTGTYSI--MIQ 607
Query 567 VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
+ L +++ F + ++ +A + L N + +
Sbjct 608 KI------LFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACR 661
Query 627 EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF---VLWWLVSSV 683
+ + F+A L+ L+ L + D S + ++ V + +++ V
Sbjct 662 DS--------ETFSAFLLDLFKLTIGMG-----DLEMLSSAKYPVVFILLLVTYIILTFV 708
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLA-GTPEATYQMTVELLFRDILEEPGEDELTERL 742
+ +N+ +AL+ E H+ L T + + + R + +
Sbjct 709 LLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSS 768
Query 743 SQHPHLWLC 751
P C
Sbjct 769 DGTPDRRWC 777
>sp|Q9Y0A1|ITPR_CAEEL Inositol 1,4,5-trisphosphate receptor itr-1
OS=Caenorhabditis elegans OX=6239 GN=itr-1 PE=1 SV=1
Length=2892
Score = 45.5 bits (106), Expect = 0.002, Method: Composition-based stats.
Identities = 31/170 (18%), Positives = 69/170 (41%), Gaps = 22/170 (13%)
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV----ALPGNSSLAPAN 618
+ + V ++V Q++ G + +++ Y F+I+G FR + +SS ++
Sbjct 2600 ETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISS 2659
Query 619 G-------SAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDA-----YRRYS 666
G S C + E N+ + + TLW ++ +Q + R
Sbjct 2660 GIPSETCPSEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNP 2719
Query 667 GPWSKIYF------VLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPL 710
PW ++ + +++V VI +NL +I++ F ++ + +
Sbjct 2720 APWEDMFIWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQI 2769
>sp|P79100|TRPC4_BOVIN Short transient receptor potential channel
4 OS=Bos taurus OX=9913 GN=TRPC4 PE=2 SV=2
Length=979
Score = 45.5 bits (106), Expect = 0.002, Method: Composition-based stats.
Identities = 28/207 (14%), Positives = 72/207 (35%), Gaps = 16/207 (8%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
GL+ Y+ N+ D ++ + L L+I Y +P +M + + +
Sbjct 425 GLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA--LFA 482
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG--VIV 606
+ +F LR+I + + + ++ ++ +++ ++ + G +
Sbjct 483 IANIFSSLRLISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
+ G ++ L NL V N + A ++
Sbjct 539 FYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTN-----VKAQHEFT 593
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 594 EFVGATMFGTYNVISLVVLLNMLIAMM 620
>sp|P56180|TPTE_HUMAN Putative tyrosine-protein phosphatase TPTE
OS=Homo sapiens OX=9606 GN=TPTE PE=1 SV=3
Length=551
Score = 45.1 bits (105), Expect = 0.002, Method: Composition-based stats.
Identities = 23/120 (19%), Positives = 51/120 (43%), Gaps = 3/120 (3%)
Query 403 LDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
L + V++ Y S + + + F G + L ++ I L+ L
Sbjct 63 LSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYI 122
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
+ + + +F +L+++LL+VF + Y S N+ D + V+LL++++ +
Sbjct 123 PLEYRSISLAIALF---FLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFF 179
>sp|Q9QUQ5|TRPC4_MOUSE Short transient receptor potential channel
4 OS=Mus musculus OX=10090 GN=Trpc4 PE=1 SV=1
Length=974
Score = 45.1 bits (105), Expect = 0.003, Method: Composition-based stats.
Identities = 28/207 (14%), Positives = 72/207 (35%), Gaps = 16/207 (8%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
GL+ Y+ N+ D ++ + L L+I Y +P +M + + +
Sbjct 425 GLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA--LFA 482
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG--VIV 606
+ +F LR+I + + + ++ ++ +++ ++ + G +
Sbjct 483 IANIFSSLRLISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
+ G ++ L NL V N + A ++
Sbjct 539 FYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTN-----VKAQHEFT 593
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 594 EFVGATMFGTYNVISLVVLLNMLIAMM 620
>sp|A7T1N0|TMP2L_NEMVE Transient receptor potential cation channel
subfamily M member-like 2 OS=Nematostella vectensis OX=45351
GN=TRPM2 PE=1 SV=1
Length=1551
Score = 45.1 bits (105), Expect = 0.003, Method: Composition-based stats.
Identities = 37/191 (19%), Positives = 69/191 (36%), Gaps = 22/191 (12%)
Query 417 YQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVF 476
Y +PF + + G+ F +L + L N A L I+ VF
Sbjct 834 YSAPFSKFVGNVVGYLAFIFLYAYVVLFNF-----PRFDPAKTLGGIHPTEIVLYF-WVF 887
Query 477 IVYYLLEMLLKVFALGLRG-------YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
+ +E + ++ A + Y S N D V ++ I
Sbjct 888 TIL--IEEIRQLAAKPPKYIKDKVSVYFSDTWNFVDIFSLTVFIIAIILRFFTNSRIFTA 945
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFL--RIIPSMKLMAVVASTVLGLVQNMRAFGGILV 587
R ++ L ++ + R L + V R L +++ K+M +A ++ L A+G L
Sbjct 946 SRI-ILSLDIIFFIVRSLQIFSVNRLLGPKLVMIQKMMQDLAQFIIILAVFTIAYGIALH 1004
Query 588 VVYY----VFA 594
V + ++A
Sbjct 1005 AVMFPSPGIYA 1015
>sp|Q9UBN4|TRPC4_HUMAN Short transient receptor potential channel
4 OS=Homo sapiens OX=9606 GN=TRPC4 PE=1 SV=1
Length=977
Score = 45.1 bits (105), Expect = 0.003, Method: Composition-based stats.
Identities = 28/207 (14%), Positives = 72/207 (35%), Gaps = 16/207 (8%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLV---LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
GL+ Y+ N+ D ++ + L L+I Y +P +M + + +
Sbjct 425 GLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA--LFA 482
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRG--VIV 606
+ +F LR+I + + + ++ ++ +++ ++ + G +
Sbjct 483 IANIFSSLRLISLFTANSHLGPLQI----SLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYS 666
+ G ++ L NL V N + A ++
Sbjct 539 FYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTN-----VKAQHEFT 593
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI 693
F + ++S V+ +N+ +A++
Sbjct 594 EFVGATMFGTYNVISLVVLLNMLIAMM 620
>sp|P19334|TRP_DROME Transient receptor potential protein OS=Drosophila
melanogaster OX=7227 GN=trp PE=1 SV=3
Length=1275
Score = 45.1 bits (105), Expect = 0.003, Method: Composition-based stats.
Identities = 35/253 (14%), Positives = 87/253 (34%), Gaps = 34/253 (13%)
Query 469 LGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHP 528
L I+ + + + E L +++ GL Y+ N+ D + + + + + + H
Sbjct 425 LAIITYIMALIF--EELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHR 482
Query 529 G--------------WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
W P LLS + + + + I + + ++
Sbjct 483 DLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGM-VFSYLKLVHIFSINPHLGPLQVSLGR 541
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN 634
++ ++ F I +V + F G+N L N A E+
Sbjct 542 MIIDIIKFFFIYTLVLFAFGC-GLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWR 600
Query 635 NFDDFAAALVTLWNLMVVNNWQVF---------LDAYRRYSGPWSKIYFVLWWLVSSVIW 685
F + +L+ W F L + ++ W+ + F + +++ ++
Sbjct 601 RFSNLFETSQSLF-------WASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVL 653
Query 686 VNLFLALILENFL 698
+N+ +A++ ++
Sbjct 654 LNMLIAMMSNSYQ 666
>sp|Q9EPK8|TRPV4_MOUSE Transient receptor potential cation channel
subfamily V member 4 OS=Mus musculus OX=10090 GN=Trpv4
PE=1 SV=1
Length=871
Score = 44.3 bits (103), Expect = 0.004, Method: Composition-based stats.
Identities = 35/249 (14%), Positives = 79/249 (32%), Gaps = 26/249 (10%)
Query 507 LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
LL + VL + + A+Y + MV L + L + ++
Sbjct 551 LLYFIYSVLVVVSAALYLAGIEAYLAVMVFAL-VLGWMNALYFTRGLKLTGTYSI--MIQ 607
Query 567 VVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSF 626
+ L +++ F + ++ +A + L P + + C
Sbjct 608 KI------LFKDLFRFLLVYLLFMIGYASALVTL------LNPCTNMKVCDEDQSNCTVP 655
Query 627 EQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYF---VLWWLVSSV 683
+ + F+A L+ L+ L + D S + ++ V + +++ V
Sbjct 656 TYPACRDS--ETFSAFLLDLFKLTIGMG-----DLEMLSSAKYPVVFILLLVTYIILTFV 708
Query 684 IWVNLFLALILENFLHKWDPRSHLQPLA-GTPEATYQMTVELLFRDILEEPGEDELTERL 742
+ +N+ +AL+ E H+ L T + + + R + +
Sbjct 709 LLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSS 768
Query 743 SQHPHLWLC 751
P C
Sbjct 769 DGTPDRRWC 777
>sp|Q8TDN1|KCNG4_HUMAN Voltage-gated potassium channel regulatory
subunit KCNG4 OS=Homo sapiens OX=9606 GN=KCNG4 PE=1 SV=1
Length=519
Score = 43.9 bits (102), Expect = 0.005, Method: Composition-based stats.
Identities = 33/170 (19%), Positives = 59/170 (35%), Gaps = 9/170 (5%)
Query 431 HYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
F L L VS+CV + + D R + + I+ + + ++ LE L
Sbjct 220 GKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCL 279
Query 487 KVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL-SLWDMT 544
+ A + P N+ D L + +S P G RP L + +
Sbjct 280 RFVQAQDKCQFFQGPLNIIDIL---AISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVL 336
Query 545 RMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
R+L L + +R+ + + TV + L V +F+
Sbjct 337 RVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFS 386
Score = 35.9 bits (81), Expect = 1.6, Method: Composition-based stats.
Identities = 35/220 (16%), Positives = 74/220 (34%), Gaps = 31/220 (14%)
Query 90 IFLILFLAFIETPSSLTSTAD-VRYRAAPWEPPCG----LTESVEVLCLLVFAADLSVKG 144
+F L + F+ T + + RA + C VE +C+ F+ + ++
Sbjct 222 VFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRF 281
Query 145 Y-LFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSL-----------------VCHEPLRI 186
F + + ++ + V VS + LR
Sbjct 282 VQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRA 341
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+L L ++S ++ +R E LLL + + + LF+
Sbjct 342 LRILYVMRLARHSLGLQTLGLTVRRCTREFG--LLLLFLAVAI------TLFSPLVYVAE 393
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNR 286
++ R+ F ++P S ++ +TT D++ +
Sbjct 394 KESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQM 433
>sp|Q5A2J7|YVC1_CANAL Calcium channel YVC1 OS=Candida albicans
(strain SC5314 / ATCC MYA-2876) OX=237561 GN=YVC1 PE=2 SV=2
Length=675
Score = 43.9 bits (102), Expect = 0.006, Method: Composition-based stats.
Identities = 31/271 (11%), Positives = 80/271 (30%), Gaps = 37/271 (14%)
Query 436 YLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRG 495
Y L +++ + +F ++ D + +F V Y+L+ +K
Sbjct 241 YQNILEIFLSIIYLIIFTIVVNTHSTLTGDIDFFETVLYLFTVGYILDEFIK-------- 292
Query 496 YLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF 555
+ N + I T+AV + R+L +
Sbjct 293 FYHVGWNYLGFWNAFNDTMYCILTVAVCFRIASVNSHGATRIKYDEISFRVLACASPLMW 352
Query 556 LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLA 615
R++ + ++ +++ M + + +V + + F G +S
Sbjct 353 SRLLLFLDAYK-FVGAMIVVLKTMMKESILFFFLLFVVIVGFLQGFIG-----LDSSDGK 406
Query 616 PANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFV 675
S + ++F+D P++ + +
Sbjct 407 NEATQRILISLVKAVIGGSSFEDMGN-----------------------LVPPYASVLYY 443
Query 676 LWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
+ + +VI +N+ +AL + + +
Sbjct 444 FYQFMLTVILMNILIALYSTAYAAIVENATD 474
>sp|Q2EG98|PK1L3_MOUSE Polycystin-1-like protein 3 OS=Mus musculus
OX=10090 GN=Pkd1l3 PE=1 SV=2
Length=2201
Score = 43.9 bits (102), Expect = 0.007, Method: Composition-based stats.
Identities = 48/348 (14%), Positives = 107/348 (31%), Gaps = 82/348 (24%)
Query 428 LFGHYYFDYLGNLIALANLV-------SICVFLVLDADVLPAERDDFILGILNCVFIVY- 479
F+ NL+ L+ + L LD+ + I++ V
Sbjct 1857 FVEFTVFNANVNLLCAVTLILESSGVGTFLTSLQLDSLTSLQSSERGFAWIVSQVVYYLL 1916
Query 480 -----YLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRP-- 532
++ LK + + N+ D + ++ + ++ L H +
Sbjct 1917 VCYYAFIQGCRLK---RQRLAFFTRKRNLLDTSIVLISFSILGLSMQSLSLLHKKMQQYH 1973
Query 533 -EMVGLLSLWDMTRM----------LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
+ +S ++ R+ L + R ++ + V+ T+ +
Sbjct 1974 CDRDRFISFYEALRVNSAVTHLRGFLLLFATVRVWDLLRHHAQLQVINKTLSKAWDEVLG 2033
Query 582 FGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAA 641
F I+VV+ +A+ LF + +++ F
Sbjct 2034 FILIIVVLLSSYAMTFNLLFG----------------------------WSISDYQSFFR 2065
Query 642 ALVTLWNLM--VVNNWQVF-LDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFL 698
++VT+ L+ + +V L + + ++ ++ +NLF++ IL F
Sbjct 2066 SIVTVVGLLMGTSKHKEVIALYPIL------GSLLVLSSIILMGLVIINLFVSAILIAFG 2119
Query 699 HKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP 746
+ E D+L + L RL Q+P
Sbjct 2120 KERKA----------------CEKEATLTDMLLQKLSSLLGIRLHQNP 2151
>sp|Q7Z442|PK1L2_HUMAN Polycystin-1-like protein 2 OS=Homo sapiens
OX=9606 GN=PKD1L2 PE=1 SV=5
Length=2459
Score = 43.9 bits (102), Expect = 0.008, Method: Composition-based stats.
Identities = 30/248 (12%), Positives = 76/248 (31%), Gaps = 49/248 (20%)
Query 470 GILNCVFIVYYLLEMLL--KVFALGLRGYLSYPSNVFDGLLTV-------------VLLV 514
++ +F++YY M++ K + GY N+ + + + VL
Sbjct 2190 ELIYFLFLLYY---MVVQGKRMSKETWGYFCSKWNLLELAIILASWSALAVFVKRAVLAE 2246
Query 515 LEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLG 574
++ +R + +L + L +L + ++ M ++ + +
Sbjct 2247 RDLQRCRNHREEGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITAALRR 2306
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN 634
++ F +++ + ++I +F + + A S G F
Sbjct 2307 AWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDAAETMVSLQLGIFN------- 2359
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
+ YS + + + +NLF+++IL
Sbjct 2360 ------------------------YEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVIL 2395
Query 695 ENFLHKWD 702
F +
Sbjct 2396 VAFSEEQK 2403
>sp|Q12324|YVC1_YEAST Calcium channel YVC1 OS=Saccharomyces cerevisiae
(strain ATCC 204508 / S288c) OX=559292 GN=YVC1 PE=1
SV=2
Length=675
Score = 43.2 bits (100), Expect = 0.010, Method: Composition-based stats.
Identities = 40/295 (14%), Positives = 95/295 (32%), Gaps = 39/295 (13%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY 499
+ + L LV++ + +L + VF ++L+ L K++ +G
Sbjct 240 QMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAH--LS 297
Query 500 PSNVF-DGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRI 558
N+F D ++ + ++V L + + R+L+ F + R+
Sbjct 298 FWNLFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKI-----SYRVLSCAAPFVWSRL 352
Query 559 IPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPAN 618
+ ++ +L ++++M + + ++ I F G+ A P
Sbjct 353 LLYLESQR-FIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGPI- 410
Query 619 GSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWW 678
+T+ L D + ++ P++ I + ++
Sbjct 411 --------------------LGNLTITVLGLGSF-------DVFEEFAPPYAAILYYGYY 443
Query 679 LVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEP 733
+ SVI +N+ +AL + D + D+ P
Sbjct 444 FIVSVILLNILIALYSTAYQKVIDNADD--EYMALMSQKTLRYIRAPDEDVYVSP 496
Score = 37.8 bits (86), Expect = 0.45, Method: Composition-based stats.
Identities = 41/224 (18%), Positives = 69/224 (31%), Gaps = 26/224 (12%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLL-GYLVVLVVSLVDWTVSLSLVCHE 182
L ES+ + F D K Y G+AH + W L L+++ ++S+
Sbjct 268 LLESIFYVFNTGFILDELTKLYYIGYAH--LSFWNLFNDTTYLIITFAMGFRAMSVTPLN 325
Query 183 -----------PLRIRRLLRPF---FLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLC 228
R+ PF LL ++ + + L M ++ L
Sbjct 326 AKYSSEDWDKISYRVLSCAAPFVWSRLLLYLES-QRFIGIMLVILKHMMKESIV-FFFLL 383
Query 229 LFTMFGM-LLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRA 287
M G F G DG+ NL ++ L P Y+
Sbjct 384 FLIMIGFTQGFLGLDSADGKRDITGPILGNLTITVLGLGSFDVFEEF----APPYAAILY 439
Query 288 YAIFFIVFTVIGSLFLMNLLTAII--YSQFRGYLMKSLQTSLFR 329
Y +FIV ++ ++ + TA M + R
Sbjct 440 YGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLR 483
>sp|Q9UIX4|KCNG1_HUMAN Voltage-gated potassium channel regulatory
subunit KCNG1 OS=Homo sapiens OX=9606 GN=KCNG1 PE=1 SV=1
Length=513
Score = 42.0 bits (97), Expect = 0.017, Method: Composition-based stats.
Identities = 44/267 (16%), Positives = 90/267 (34%), Gaps = 28/267 (10%)
Query 370 QLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRP---------EYQSP 420
LD K+ ++K+ + ++ EE + LD P
Sbjct 160 HLDGCCKRRYLQKIEEFAEMVEREEED----DALDSEGRDSEGPAEGEGRLGRCMRRLRD 215
Query 421 FLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGILNCVF 476
++ F L L V++ V + + + + + I+ V
Sbjct 216 MVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVC 275
Query 477 IVYYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMV 535
+ ++ LE LL++ A +L P + D + + + + A PG
Sbjct 276 VGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSY- 334
Query 536 GLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
L + +L +L R L ++ + + + L + R FG +L+ F
Sbjct 335 ----LDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLL-----FLC 385
Query 596 IGINLFRGVIVALPGNSSLAPANGSAP 622
+ I LF ++ + + +P S P
Sbjct 386 VAIALFAPLLYVIENEMADSPEFTSIP 412
Score = 37.0 bits (84), Expect = 0.79, Method: Composition-based stats.
Identities = 47/274 (17%), Positives = 89/274 (32%), Gaps = 39/274 (14%)
Query 68 ASSMWLYRRYYSNVCQR---TLSFTIFLILFLAFI-----ETPSSLTSTADVRYRAAPWE 119
+ R ++ +R L +F L + F+ S +
Sbjct 203 EGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCS 262
Query 120 PPCGLTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVLV---VSLVDWTV- 174
C VE +C+ F+ + ++ F ++ L LV ++ ++L+
Sbjct 263 QMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAA 322
Query 175 ----------SLSLVCHEPLRIRRLLRPF---FLLQNSSMMKKTLKCIRWSLPEMASVGL 221
S LR+ R LR L ++S ++ R E
Sbjct 323 AGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFG---- 378
Query 222 LLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPA 281
LL + LC+ + LFA + F ++P ++ +TT D M+P
Sbjct 379 LLLLFLCV----AIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGD-MVPR 433
Query 282 YSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+ + A+ I + + LM I+ F
Sbjct 434 STPGQVVALSSI----LSGILLMAFPVTSIFHTF 463
>sp|Q9NTG1|PKDRE_HUMAN Polycystin family receptor for egg jelly
OS=Homo sapiens OX=9606 GN=PKDREJ PE=1 SV=2
Length=2253
Score = 42.0 bits (97), Expect = 0.026, Method: Composition-based stats.
Identities = 53/440 (12%), Positives = 127/440 (29%), Gaps = 74/440 (17%)
Query 329 RRRLGTRAAFEV-LSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYG 387
RR + + + G + + + + +YG
Sbjct 1818 RREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLYYSYGLLHTYG 1877
Query 388 SV---LLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLF-GHYYFDYLGNLIAL 443
S L E Q+ + L ++E + + + F+ NL
Sbjct 1878 SGGYALYFFPEQQRFNSTLRLKELQE-------SNWLDEKTWAVVLELTTFNPDINLFCS 1930
Query 444 ANLV-----------SICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE--MLLKVFA 490
+++ SI + AD + L + +F + Y+++ ++
Sbjct 1931 ISVIFEVSQLGVVNTSISLHSFSLADFDRKASAEIYLYVAILIFFLAYVVDEGCIIMQ-- 1988
Query 491 LGLRGYLSYPSNVFDGLLTVVLLVLEIS---------TLAVYRLPHPGWRPEMVGLLSLW 541
Y+ N+ + L + VL + + + L +P + +
Sbjct 1989 -ERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQVD 2047
Query 542 DMTRM----LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIG 597
+ R+ L L + + LR + + + + + ++ V ++V+ G
Sbjct 2048 HIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFG 2107
Query 598 INLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQV 657
+F N+ + + T+++ V
Sbjct 2108 YLVFG----------------------------QHEWNYSNLIHSTQTVFSYCVSA---- 2135
Query 658 FLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
F + + ++ + LV + +NLF A+IL + + + +P T
Sbjct 2136 FQNTEFSNNRILGVLFLSSFMLVMICVLINLFQAVILSAY-EEMKQPVYEEPSDEVEAMT 2194
Query 718 YQMTVELLFRDILEEPGEDE 737
Y L + +
Sbjct 2195 YLCRKLRTMFSFLTSQSKAK 2214
>sp|D4AD53|KCNG1_RAT Voltage-gated potassium channel regulatory
subunit KCNG1 OS=Rattus norvegicus OX=10116 GN=Kcng1 PE=1
SV=1
Length=514
Score = 41.6 bits (96), Expect = 0.027, Method: Composition-based stats.
Identities = 49/287 (17%), Positives = 91/287 (32%), Gaps = 39/287 (14%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVC---QRTLSFTIFLILFLAFI-----ETPSSLT 106
D+ S + R ++ L +F L + F+ S
Sbjct 190 DSEDQESEGPSTSEGRLSRCMRRLRDMVEKPHSGLPGKVFACLSVLFVTVTAVNLSVSTL 249
Query 107 STADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVL 165
+ C VE +C+ F+ + ++ F ++ L LV +
Sbjct 250 PSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAI 309
Query 166 V---VSLVDWTVSLSLVCHEP-----------LRIRRLLRPF---FLLQNSSMMKKTLKC 208
+ V+L+ + S LR+ R LR L ++S ++
Sbjct 310 LPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLT 369
Query 209 IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVL 268
R E LL + LC+ + LFA + F ++P ++
Sbjct 370 ARRCTREFG----LLLLFLCV----AIALFAPLLYVIENEMADSPEFTSIPACYWWAVIT 421
Query 269 LTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+TT D M+P + + A+ I + + LM I+ F
Sbjct 422 MTTVGYGD-MVPRSTPGQVVALSSI----LSGILLMAFPVTSIFHTF 463
Score = 39.7 bits (91), Expect = 0.11, Method: Composition-based stats.
Identities = 38/197 (19%), Positives = 73/197 (37%), Gaps = 15/197 (8%)
Query 431 HYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
F L L V++ V + + + + + I+ V + ++ LE LL
Sbjct 226 GKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLL 285
Query 487 KVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
+ A +L P + D +V ++ TL V +P G L +
Sbjct 286 RFIQAPSKFAFLRSPLTLID----LVAILPYYVTLLVDGAASSRRKPS-TGNSYLDKVGL 340
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+L +L R L ++ + + + L + R FG +L+ F + I LF ++
Sbjct 341 VLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLL-----FLCVAIALFAPLL 395
Query 606 VALPGNSSLAPANGSAP 622
+ + +P S P
Sbjct 396 YVIENEMADSPEFTSIP 412
>sp|Q28265|KCMA1_CANLF Calcium-activated potassium channel subunit
alpha-1 (Fragment) OS=Canis lupus familiaris OX=9615 GN=KCNMA1
PE=2 SV=2
Length=1159
Score = 41.6 bits (96), Expect = 0.035, Method: Composition-based stats.
Identities = 36/210 (17%), Positives = 65/210 (31%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 130 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAAN----- 175
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
NLW + +V V +S+ + R LR L+Q S +++ L
Sbjct 176 DNLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 230
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 231 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNSQALTYWECVYLLMVT 287
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V FIVF ++G L +
Sbjct 288 MSTVGYGDVYAKTTPGGLFIVFFILGGLAM 317
>sp|A2BDX4|KCNG1_MOUSE Voltage-gated potassium channel regulatory
subunit KCNG1 OS=Mus musculus OX=10090 GN=Kcng1 PE=3 SV=1
Length=514
Score = 40.9 bits (94), Expect = 0.039, Method: Composition-based stats.
Identities = 50/287 (17%), Positives = 93/287 (32%), Gaps = 39/287 (14%)
Query 55 DAIQYRSINHRVDASSMWLYRRYYSNVCQR---TLSFTIFLILFLAFI-----ETPSSLT 106
D+ S + R ++ +R L +F L + F+ S
Sbjct 190 DSEDQESEGPSASEGRLSRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTL 249
Query 107 STADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGY-LFGWAHFQKNLWLLGYLVVL 165
+ C VE +C+ F+ + ++ F ++ L LV +
Sbjct 250 PSLREEEEQGQCSQMCHNVFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAI 309
Query 166 V---VSLVDWTVSLSLVCHEP-----------LRIRRLLRPF---FLLQNSSMMKKTLKC 208
+ V+L+ + S LR+ R LR L ++S ++
Sbjct 310 LPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLT 369
Query 209 IRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVL 268
R E LL + LC+ + LFA + F ++P ++
Sbjct 370 ARRCTREFG----LLLLFLCV----AIALFAPLLYVIENEMADSPEFTSIPACYWWAVIT 421
Query 269 LTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+TT D M+P + + A+ I + + LM I+ F
Sbjct 422 MTTVGYGD-MVPRSTPGQVVALSSI----LSGILLMAFPVTSIFHTF 463
Score = 40.1 bits (92), Expect = 0.088, Method: Composition-based stats.
Identities = 38/212 (18%), Positives = 75/212 (35%), Gaps = 15/212 (7%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGI 471
++ F L L V++ V + + + + + I
Sbjct 211 RRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNVFI 270
Query 472 LNCVFIVYYLLEMLLKVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGW 530
+ V + ++ LE LL+ A +L P + D +V ++ TL V
Sbjct 271 VESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLID----LVAILPYYVTLLVDGAASSRR 326
Query 531 RPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVY 590
+P G L + +L +L R L ++ + + + L + R FG +L+
Sbjct 327 KPS-TGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLL--- 382
Query 591 YVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
F + I LF ++ + + +P S P
Sbjct 383 --FLCVAIALFAPLLYVIENEMADSPEFTSIP 412
>sp|Q7TN88|PK1L2_MOUSE Polycystin-1-like protein 2 OS=Mus musculus
OX=10090 GN=Pkd1l2 PE=2 SV=1
Length=2461
Score = 41.2 bits (95), Expect = 0.041, Method: Composition-based stats.
Identities = 37/289 (13%), Positives = 87/289 (30%), Gaps = 54/289 (19%)
Query 474 CVFIVYYLLEMLL--KVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG-- 529
+F+ YY M++ K+ GY N+ + + + + + L
Sbjct 2197 FLFLFYY---MVVQGKLMRKQKWGYFCSKWNLLEVAIILASWSALVVFVKRTILADRDLQ 2253
Query 530 ----------WRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNM 579
+ +L + L +L + ++ M ++ S + ++
Sbjct 2254 RYREHREGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRRAWGDI 2313
Query 580 RAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
F +++++ ++ +F + + A S G F
Sbjct 2314 SGFVAVILIMLLAYSFASNLVFGWKLRSYKTLFDAAETMVSLQLGIFN------------ 2361
Query 640 AAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLH 699
+ YS + + + + +NLF+++IL F
Sbjct 2362 -------------------YEEVLDYSPILGSLLIGSCIVFMTFVVLNLFISVILVAFSE 2402
Query 700 KWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHL 748
+ L+ E + V++L + E+ T S+ P L
Sbjct 2403 EQKS----DQLSEEGEIADLLLVKILSFLGIRCKREE--TWSSSEQPEL 2445
>sp|Q8R4F0|MCLN3_MOUSE Mucolipin-3 OS=Mus musculus OX=10090 GN=Mcoln3
PE=1 SV=1
Length=553
Score = 40.9 bits (94), Expect = 0.047, Method: Composition-based stats.
Identities = 45/266 (17%), Positives = 94/266 (35%), Gaps = 46/266 (17%)
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
FD L LA+LV +C V+ L E +F F+++Y E +
Sbjct 286 MIFDAFVILTCLASLV-LCARSVIRGLQLQQEFVNF--------FLLHYKKE-----VSA 331
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+ +++++ +I T+ L + + ML+
Sbjct 332 SDQMEFINGWY-------IMIIISDILTIVGSVLKMEIQAKSLTSYDVCSILLGTSTMLV 384
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
+R + ++ T+ + N+ F ++Y + F G IV P +
Sbjct 385 WLGVIRYLGFFAKYNLLILTLQAALPNVMRFCCCAAMIYLGYC------FCGWIVLGPYH 438
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
N + C + N DD + + + M ++ V+L +S+
Sbjct 439 EKFRSLNRVSECL------FSLINGDD----MFSTFAKMQQKSYLVWL---------FSR 479
Query 672 IYFVLWWLVSSVIWVNLFLALILENF 697
+Y + + + ++LF+ALI + +
Sbjct 480 VYLYSFISLFIYMILSLFIALITDTY 505
>sp|Q80XM3|KCNG4_MOUSE Voltage-gated potassium channel regulatory
subunit KCNG4 OS=Mus musculus OX=10090 GN=Kcng4 PE=2 SV=1
Length=506
Score = 40.5 bits (93), Expect = 0.061, Method: Composition-based stats.
Identities = 36/202 (18%), Positives = 69/202 (34%), Gaps = 15/202 (7%)
Query 431 HYYFDYLGNLIALANLVSICVFLV----LDADVLPAERDDFILGILNCVFIVYYLLEMLL 486
F L L VS+CV + + R + + ++ + + ++ LE L
Sbjct 218 GKVFACLSVLFVATTAVSLCVSTMPDFRAEEGKGECTRKCYYIFVVESICVAWFSLEFCL 277
Query 487 KVF-ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
+ A + P NV D L + +S P G RP L +
Sbjct 278 RFVQAPNKCQFFRGPLNVIDIL---AISPYYVSLAVSDESPEAGERPSSSSYL--EKVGL 332
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
+L +L R L ++ + ++ T+ V+ G+L++ + + LF ++
Sbjct 333 VLRVLRALRILYVMRLARH-SLGLQTLGLTVRRCAREFGLLMLFL----AVAVTLFSPLV 387
Query 606 VALPGNSSLAPANGSAPCGSFE 627
S S P +
Sbjct 388 YVAENESGRVLEFTSIPASYWW 409
Score = 36.2 bits (82), Expect = 1.3, Method: Composition-based stats.
Identities = 41/271 (15%), Positives = 91/271 (34%), Gaps = 38/271 (14%)
Query 90 IFLILFLAFIETPSSLTSTAD-VRYRAAPWEPPCG----LTESVEVLCLLVFAADLSVKG 144
+F L + F+ T + + +RA + C VE +C+ F+ + ++
Sbjct 220 VFACLSVLFVATTAVSLCVSTMPDFRAEEGKGECTRKCYYIFVVESICVAWFSLEFCLRF 279
Query 145 Y-LFGWAHFQKNLWLLGYLVVLV---VSLV--------------DWTVSLSLVCHEPLRI 186
F + + ++ + VSL + + LR
Sbjct 280 VQAPNKCQFFRGPLNVIDILAISPYYVSLAVSDESPEAGERPSSSSYLEKVGLVLRVLRA 339
Query 187 RRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDG 246
R+L L ++S ++ +R E LL + L + + LF+
Sbjct 340 LRILYVMRLARHSLGLQTLGLTVRRCAREFG----LLMLFLAV----AVTLFSPLVYVAE 391
Query 247 QDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNL 306
+ R+ F ++P S ++ +TT D++ + + +++ + +M
Sbjct 392 NESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQM-----VALSSILSGILIMAF 446
Query 307 LTAIIYSQFRG--YLMKSLQTSLFRRRLGTR 335
I+ F +K Q + R +
Sbjct 447 PATSIFHTFSHSYLELKREQEQVQARLRRLQ 477
>sp|P59053|KCNG3_MOUSE Voltage-gated potassium channel regulatory
subunit KCNG3 OS=Mus musculus OX=10090 GN=Kcng3 PE=2 SV=1
Length=433
Score = 40.1 bits (92), Expect = 0.071, Method: Composition-based stats.
Identities = 20/138 (14%), Positives = 47/138 (34%), Gaps = 10/138 (7%)
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY-PSNVFDGLLTVVLLVLEIS 518
A GI+ + I ++ E +++ + P N+ D L + +
Sbjct 209 YSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLM 268
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
T+ + E L R+L M+ +F +++ + + T+ +
Sbjct 269 TV---------FTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYRE 319
Query 579 MRAFGGILVVVYYVFAII 596
M + V +F+ +
Sbjct 320 MAMLLVFICVAMAIFSAL 337
Score = 38.9 bits (89), Expect = 0.17, Method: Composition-based stats.
Identities = 38/215 (18%), Positives = 79/215 (37%), Gaps = 24/215 (11%)
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGYLVVLV---- 166
RY A+P P G+ +E +C+ F A+ V+ F K + L+ +
Sbjct 208 RYSASPGREPSGI---IEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYI 264
Query 167 -VSLVDWTVSLSLV-----CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVG 220
V + +T S + LR+ R+ L ++ ++ ++ EMA +
Sbjct 265 SVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMAMLL 324
Query 221 LLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP 280
+ + + + +F+ LL + F ++P + +++ +TT D+
Sbjct 325 VFICVAMAIFSALSQLL-----EHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPI 379
Query 281 AYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+ V+ + L+ L IY F
Sbjct 380 TVPGRILGGV-----CVVSGIVLLALPITFIYHSF 409
>sp|Q61143|TRPC6_MOUSE Short transient receptor potential channel
6 OS=Mus musculus OX=10090 GN=Trpc6 PE=1 SV=3
Length=930
Score = 40.1 bits (92), Expect = 0.079, Method: Composition-based stats.
Identities = 26/235 (11%), Positives = 67/235 (29%), Gaps = 37/235 (16%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY-------RLPHPGWRPEMVGLLSLWDMT 544
G + YL N+ D + + I+ + + + + ++L D
Sbjct 516 GPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNV 575
Query 545 RMLNMLIV-------------FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI---LVV 588
+ N+ + + ++ S +A + + G +
Sbjct 576 KYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFK 635
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+F ++ + G+ +F A+ L
Sbjct 636 FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEE---------SFKTLFWAIFGLSE 686
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
+ V V ++ +Y V + + ++ +N+ +A+I +F D
Sbjct 687 VKSV----VINYNHKFIENIGYVLYGV-YNVTMVIVLLNMLIAMINSSFQEIEDD 736
>sp|Q9JLG4|PK2L2_MOUSE Polycystin-2-like protein 2 OS=Mus musculus
OX=10090 GN=Pkd2l2 PE=2 SV=2
Length=621
Score = 40.1 bits (92), Expect = 0.082, Method: Composition-based stats.
Identities = 32/244 (13%), Positives = 87/244 (36%), Gaps = 47/244 (19%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTV-------------VLLVLE 516
++ C+F+ ++++ L KV Y N + LL + + L
Sbjct 286 EVIFCIFLFVFIIQELRKVNEFK-SAYFRSVWNWLEMLLLLLCFLAVSFYAYCNMQSFLL 344
Query 517 ISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLV 576
+ L +P + + ++ + + + I + M+ ++ST+ +
Sbjct 345 LGQLLKNTDSYPDFYFLAYWHIYYNNVIAITIFFAWIKIFKFISFNETMSQLSSTLSRCM 404
Query 577 QNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNF 636
+++ F + +++ +A +G +F + ++F
Sbjct 405 KDIVGFAIMFFIIFSAYAQLGFLVFGSQV----------------------------DDF 436
Query 637 DDFAAALVTLWNLMVVN-NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE 695
F ++ + +++ + N+ A IYF+ + + +N+FLA+I +
Sbjct 437 STFQNSIFAQFRIVLGDFNFAGIQQANWILGP----IYFITFIFFVFFVLLNMFLAIIND 492
Query 696 NFLH 699
+
Sbjct 493 TYSE 496
>sp|Q9MYW0|TRPC6_BOVIN Short transient receptor potential channel
6 OS=Bos taurus OX=9913 GN=TRPC6 PE=2 SV=2
Length=931
Score = 40.1 bits (92), Expect = 0.084, Method: Composition-based stats.
Identities = 26/235 (11%), Positives = 67/235 (29%), Gaps = 37/235 (16%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY-------RLPHPGWRPEMVGLLSLWDMT 544
G + YL N+ D + + I+ + + + + ++L D
Sbjct 517 GPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNV 576
Query 545 RMLNMLIV-------------FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI---LVV 588
+ N+ + + ++ S +A + + G +
Sbjct 577 KYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFK 636
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+F ++ + G+ +F A+ L
Sbjct 637 FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEE---------SFKTLFWAIFGLSE 687
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
+ V V ++ +Y V + + ++ +N+ +A+I +F D
Sbjct 688 VKSV----VINYNHKFIENIGYVLYGV-YNVTMVIVLLNMLIAMINSSFQEIEDD 737
>sp|Q9Y210|TRPC6_HUMAN Short transient receptor potential channel
6 OS=Homo sapiens OX=9606 GN=TRPC6 PE=1 SV=1
Length=931
Score = 40.1 bits (92), Expect = 0.091, Method: Composition-based stats.
Identities = 26/235 (11%), Positives = 67/235 (29%), Gaps = 37/235 (16%)
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVY-------RLPHPGWRPEMVGLLSLWDMT 544
G + YL N+ D + + I+ + + + + ++L D
Sbjct 517 GPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNV 576
Query 545 RMLNMLIV-------------FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGI---LVV 588
+ N+ + + ++ S +A + + G +
Sbjct 577 KYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFK 636
Query 589 VYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWN 648
+F ++ + G+ +F A+ L
Sbjct 637 FMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEE---------SFKTLFWAIFGLSE 687
Query 649 LMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
+ V V ++ +Y V + + ++ +N+ +A+I +F D
Sbjct 688 VKSV----VINYNHKFIENIGYVLYGV-YNVTMVIVLLNMLIAMINSSFQEIEDD 737
>sp|Q09624|PKD1_CAEEL Location of vulva defective 1 OS=Caenorhabditis
elegans OX=6239 GN=lov-1 PE=1 SV=4
Length=3284
Score = 40.1 bits (92), Expect = 0.10, Method: Composition-based stats.
Identities = 29/185 (16%), Positives = 67/185 (36%), Gaps = 41/185 (22%)
Query 554 RFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSS 613
+ +RI+ + + V+A+T+ + + +FG + + F++ F V+ A+ GN
Sbjct 3061 KMIRILRFNRRIGVLAATLDNALGAIVSFG----IAFLFFSMT----FNSVLYAVLGNKM 3112
Query 614 LAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIY 673
F A ++ ++ + P S+
Sbjct 3113 -------------GGYRSLMATFQTALAGMLGKLDVTSI--------------QPISQFA 3145
Query 674 FVL---WWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDIL 730
FV+ + + S + + L++ +I+ F + R+ + E + + R L
Sbjct 3146 FVVIMLYMIAGSKLVLQLYVTIIMFEF---EEIRNDSEKQTNDYEIIDHIKYKTKRRLGL 3202
Query 731 EEPGE 735
EP +
Sbjct 3203 LEPKD 3207
>sp|Q8R523|KCNG3_RAT Voltage-gated potassium channel regulatory
subunit KCNG3 OS=Rattus norvegicus OX=10116 GN=Kcng3 PE=2
SV=2
Length=433
Score = 39.3 bits (90), Expect = 0.11, Method: Composition-based stats.
Identities = 20/138 (14%), Positives = 47/138 (34%), Gaps = 10/138 (7%)
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY-PSNVFDGLLTVVLLVLEIS 518
A GI+ + I ++ E +++ + P N+ D L + +
Sbjct 209 YSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLM 268
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
T+ + E L R+L M+ +F +++ + + T+ +
Sbjct 269 TV---------FTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYRE 319
Query 579 MRAFGGILVVVYYVFAII 596
M + V +F+ +
Sbjct 320 MVMLLVFICVAMAIFSAL 337
Score = 38.2 bits (87), Expect = 0.33, Method: Composition-based stats.
Identities = 41/217 (19%), Positives = 79/217 (36%), Gaps = 28/217 (13%)
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGYLVVLV---- 166
RY A+P P G+ +E +C+ F A+ V+ F K + L+ +
Sbjct 208 RYSASPGREPSGI---IEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYI 264
Query 167 -VSLVDWTVSLSLV-----CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVG 220
V + +T S + LR+ R+ L ++ ++ ++ EM V
Sbjct 265 SVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREM--VM 322
Query 221 LLLAI--HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
LL+ I + +F+ LL + F ++P + +++ +TT D+
Sbjct 323 LLVFICVAMAIFSALSQLL-----EHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMY 377
Query 279 IPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+ V+ + L+ L IY F
Sbjct 378 PITVPGRILGGV-----CVVSGIVLLALPITFIYHSF 409
>sp|P58126|KCNQ3_BOVIN Potassium voltage-gated channel subfamily
KQT member 3 OS=Bos taurus OX=9913 GN=KCNQ3 PE=2 SV=1
Length=866
Score = 39.3 bits (90), Expect = 0.15, Method: Composition-based stats.
Identities = 50/342 (15%), Positives = 108/342 (32%), Gaps = 49/342 (14%)
Query 128 VEVLCLLVFAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSL-VDWTVSL 176
+E + +F A+ +++ + G W F + + + VL+ S+ V +
Sbjct 159 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQ 218
Query 177 SLVCHEPLRIRRLLRPFFLLQ------NSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLF 230
V LR R L+ +L+ ++ + L +G L I
Sbjct 219 GNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLIL---- 274
Query 231 TMFGMLLF-AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN---- 285
+ F + L + D Q E F+ ++L L+ L T D +
Sbjct 275 SSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAA 334
Query 286 ----RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKS--------LQTSLFRRRLG 333
+ F + ++GS + + F + + R+
Sbjct 335 TFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRID 394
Query 334 TRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSA 393
A + S+V + + L +L +V+L + K+ + +V
Sbjct 395 LVATWRFYESVVSFPFFRKEQLDPAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNV---- 450
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFD 435
+ ++ S KE P ++A + + ++
Sbjct 451 -------DAIEESPSKEPKPVGSNNKERFRTAFRMKAYAFWQ 485
Score = 34.3 bits (77), Expect = 5.6, Method: Composition-based stats.
Identities = 35/237 (15%), Positives = 70/237 (30%), Gaps = 47/237 (20%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
L LI L L+ + + + + + L +L I + E L+++A
Sbjct 128 LVFLIVLGCLILAVLTTFREYETVSGDW----LLLLETFAIFIFGAEFALRIWAAGCCCR 183
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P + D + +L+ + +AV + L R
Sbjct 184 YKGWRGRLKFARKPLCMLD----IFVLIASVPVVAVGNQGNV-----------LATSLRS 228
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L L + R LR+ ++ S + + + I + + + + L
Sbjct 229 LRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLT-LILSSFLVYL------ 281
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL----MVVNNWQVFL 659
+ + E Y D L+TL + W+ L
Sbjct 282 ---VEKDVPEVDAQGEEMKEEFETYA----DALWWGLITLATIGYGDKTPKTWEGRL 331
>sp|Q12791|KCMA1_HUMAN Calcium-activated potassium channel subunit
alpha-1 OS=Homo sapiens OX=9606 GN=KCNMA1 PE=1 SV=2
Length=1236
Score = 39.3 bits (90), Expect = 0.15, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 192 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 239
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 240 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 292
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 293 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 349
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 350 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379
>sp|Q62976|KCMA1_RAT Calcium-activated potassium channel subunit
alpha-1 OS=Rattus norvegicus OX=10116 GN=Kcnma1 PE=1 SV=3
Length=1209
Score = 39.3 bits (90), Expect = 0.16, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 193 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 240
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 241 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 293
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 294 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 350
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 351 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 380
>sp|O18866|KCMA1_PIG Calcium-activated potassium channel subunit
alpha-1 (Fragment) OS=Sus scrofa OX=9823 GN=KCNMA1 PE=2 SV=2
Length=1152
Score = 39.3 bits (90), Expect = 0.17, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 166 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 213
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 214 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 266
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 267 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 323
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 324 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 353
>sp|Q28204|KCMA1_BOVIN Calcium-activated potassium channel subunit
alpha-1 OS=Bos taurus OX=9913 GN=KCNMA1 PE=1 SV=2
Length=1166
Score = 39.3 bits (90), Expect = 0.17, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 180 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 227
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 228 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 280
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 281 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 337
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 338 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 367
>sp|Q9BG98|KCMA1_RABIT Calcium-activated potassium channel subunit
alpha-1 OS=Oryctolagus cuniculus OX=9986 GN=KCNMA1 PE=1
SV=1
Length=1179
Score = 39.3 bits (90), Expect = 0.17, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 193 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 240
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 241 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 293
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 294 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 350
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 351 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 380
>sp|O18867|KCMA1_MACMU Calcium-activated potassium channel subunit
alpha-1 (Fragment) OS=Macaca mulatta OX=9544 GN=KCNMA1
PE=2 SV=1
Length=1151
Score = 39.3 bits (90), Expect = 0.17, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 165 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 212
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 213 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 265
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 266 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 322
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 323 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 352
>sp|Q08460|KCMA1_MOUSE Calcium-activated potassium channel subunit
alpha-1 OS=Mus musculus OX=10090 GN=Kcnma1 PE=1 SV=2
Length=1209
Score = 39.3 bits (90), Expect = 0.17, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 192 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 239
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 240 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 292
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + + T AG + FQN V L
Sbjct 293 KTSNSIKLVNLLSIFISTWLTA---AGFIHLVENSGDPWENFQNNQALTYWECVYLLMVT 349
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 350 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 379
>sp|Q8TAE7|KCNG3_HUMAN Voltage-gated potassium channel regulatory
subunit KCNG3 OS=Homo sapiens OX=9606 GN=KCNG3 PE=1 SV=1
Length=436
Score = 38.6 bits (88), Expect = 0.20, Method: Composition-based stats.
Identities = 20/138 (14%), Positives = 47/138 (34%), Gaps = 10/138 (7%)
Query 460 LPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSY-PSNVFDGLLTVVLLVLEIS 518
A GI+ + I ++ E +++ + P N+ D L + +
Sbjct 212 YSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLM 271
Query 519 TLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQN 578
T+ + E L R+L M+ +F +++ + + T+ +
Sbjct 272 TV---------FTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYRE 322
Query 579 MRAFGGILVVVYYVFAII 596
M + V +F+ +
Sbjct 323 MVMLLVFICVAMAIFSAL 340
Score = 37.8 bits (86), Expect = 0.40, Method: Composition-based stats.
Identities = 41/217 (19%), Positives = 78/217 (36%), Gaps = 28/217 (13%)
Query 112 RYRAAPWEPPCGLTESVEVLCLLVFAADLSVKG-YLFGWAHFQKNLWLLGYLVVLV---- 166
RY A P P G+ +E +C+ F A+ V+ F K + L+ +
Sbjct 211 RYSAGPGREPSGI---IEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYI 267
Query 167 -VSLVDWTVSLSLV-----CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVG 220
V + +T S + LR+ R+ L ++ ++ ++ EM V
Sbjct 268 SVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREM--VM 325
Query 221 LLLAI--HLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVM 278
LL+ I + +F+ LL + F ++P + +++ +TT D+
Sbjct 326 LLVFICVAMAIFSALSQLL-----EHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMY 380
Query 279 IPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQF 315
+ V+ + L+ L IY F
Sbjct 381 PITVPGRILGGV-----CVVSGIVLLALPITFIYHSF 412
>sp|O88944|KCNQ3_RAT Potassium voltage-gated channel subfamily
KQT member 3 OS=Rattus norvegicus OX=10116 GN=Kcnq3 PE=1 SV=2
Length=873
Score = 38.6 bits (88), Expect = 0.29, Method: Composition-based stats.
Identities = 16/81 (20%), Positives = 33/81 (41%), Gaps = 11/81 (14%)
Query 128 VEVLCLLVFAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSL-VDWTVSL 176
+E + +F A+ +++ + G W F + + + VL+ S+ V +
Sbjct 160 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQ 219
Query 177 SLVCHEPLRIRRLLRPFFLLQ 197
V LR R L+ +L+
Sbjct 220 GNVLATSLRSLRFLQILRMLR 240
Score = 34.3 bits (77), Expect = 5.7, Method: Composition-based stats.
Identities = 27/174 (16%), Positives = 57/174 (33%), Gaps = 30/174 (17%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
L LI L L+ + + + + + L +L I + E L+++A
Sbjct 129 LVFLIVLGCLILAVLTTFKEYETVSGDW----LLLLETFAIFIFGAEFALRIWAAGCCCR 184
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P + D + +L+ + +AV + L R
Sbjct 185 YKGWRGRLKFARKPLCMLD----IFVLIASVPVVAVGNQGNV-----------LATSLRS 229
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
L L + R LR+ ++ S + + + I + + + + L
Sbjct 230 LRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLT-LILSSFLVYL 282
>sp|Q8K3F6|KCNQ3_MOUSE Potassium voltage-gated channel subfamily
KQT member 3 OS=Mus musculus OX=10090 GN=Kcnq3 PE=1 SV=2
Length=873
Score = 38.6 bits (88), Expect = 0.29, Method: Composition-based stats.
Identities = 16/81 (20%), Positives = 33/81 (41%), Gaps = 11/81 (14%)
Query 128 VEVLCLLVFAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSL-VDWTVSL 176
+E + +F A+ +++ + G W F + + + VL+ S+ V +
Sbjct 160 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQ 219
Query 177 SLVCHEPLRIRRLLRPFFLLQ 197
V LR R L+ +L+
Sbjct 220 GNVLATSLRSLRFLQILRMLR 240
Score = 34.3 bits (77), Expect = 5.7, Method: Composition-based stats.
Identities = 27/174 (16%), Positives = 57/174 (33%), Gaps = 30/174 (17%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
L LI L L+ + + + + + L +L I + E L+++A
Sbjct 129 LVFLIVLGCLILAVLTTFKEYETVSGDW----LLLLETFAIFIFGAEFALRIWAAGCCCR 184
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P + D + +L+ + +AV + L R
Sbjct 185 YKGWRGRLKFARKPLCMLD----IFVLIASVPVVAVGNQGNV-----------LATSLRS 229
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINL 600
L L + R LR+ ++ S + + + I + + + + L
Sbjct 230 LRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLT-LILSSFLVYL 282
>sp|O43525|KCNQ3_HUMAN Potassium voltage-gated channel subfamily
KQT member 3 OS=Homo sapiens OX=9606 GN=KCNQ3 PE=1 SV=2
Length=872
Score = 38.2 bits (87), Expect = 0.32, Method: Composition-based stats.
Identities = 16/81 (20%), Positives = 33/81 (41%), Gaps = 11/81 (14%)
Query 128 VEVLCLLVFAADLSVKGYLFG-------WA---HFQKNLWLLGYLVVLVVSL-VDWTVSL 176
+E + +F A+ +++ + G W F + + + VL+ S+ V +
Sbjct 159 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQ 218
Query 177 SLVCHEPLRIRRLLRPFFLLQ 197
V LR R L+ +L+
Sbjct 219 GNVLATSLRSLRFLQILRMLR 239
Score = 34.3 bits (77), Expect = 5.8, Method: Composition-based stats.
Identities = 35/237 (15%), Positives = 70/237 (30%), Gaps = 47/237 (20%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFA------ 490
L LI L L+ + + + + + L +L I + E L+++A
Sbjct 128 LVFLIVLGCLILAVLTTFKEYETVSGDW----LLLLETFAIFIFGAEFALRIWAAGCCCR 183
Query 491 ----LGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRM 546
G + P + D + +L+ + +AV + L R
Sbjct 184 YKGWRGRLKFARKPLCMLD----IFVLIASVPVVAVGNQGNV-----------LATSLRS 228
Query 547 LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIV 606
L L + R LR+ ++ S + + + I + + + + L
Sbjct 229 LRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLT-LILSSFLVYL------ 281
Query 607 ALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL----MVVNNWQVFL 659
+ + E Y D L+TL + W+ L
Sbjct 282 ---VEKDVPEVDAQGEEMKEEFETYA----DALWWGLITLATIGYGDKTPKTWEGRL 331
>sp|Q6XPS3|TPTE2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate
3-phosphatase TPTE2 OS=Homo sapiens OX=9606 GN=TPTE2 PE=1
SV=2
Length=522
Score = 38.2 bits (87), Expect = 0.35, Method: Composition-based stats.
Identities = 22/126 (17%), Positives = 53/126 (42%), Gaps = 3/126 (2%)
Query 397 QKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD 456
+ + L + V++ Y S + + + F G + L ++ + L+
Sbjct 39 KSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFT 98
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
L + + + +F +L+++LL+VF G + Y S N+ D + V+ L+++
Sbjct 99 DSKLYIPLEYRSISLAIGLF---FLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVD 155
Query 517 ISTLAV 522
+ +
Sbjct 156 VIYIFF 161
>sp|Q00357|TOXA_COCCA MFS-type transporter TOXA OS=Cochliobolus
carbonum OX=5017 GN=TOXA PE=3 SV=1
Length=548
Score = 37.8 bits (86), Expect = 0.38, Method: Composition-based stats.
Identities = 29/175 (17%), Positives = 57/175 (33%), Gaps = 14/175 (8%)
Query 76 RYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLV 135
+ + + IL L F P S S + V + G + + ++
Sbjct 202 WRWCFWINLPIGAAVCAIL-LFFFHPPRSTYSASGVPRSYS---EILGNLDYIGAGMIIS 257
Query 136 FAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPF-F 194
LS+ G + + ++ LVV V + + + L RLLR F
Sbjct 258 SLVCLSLALQWGGTKYKWGDGRVVALLVVFGVLFLSASGHQYWKGEKALFPTRLLRQRGF 317
Query 195 LLQNSSMM---KKTLKCI------RWSLPEMASVGLLLAIHLCLFTMFGMLLFAG 240
LL + + + ++ VG + + + + G+ + AG
Sbjct 318 LLSLFNGLCFGGVQYAALYYLPTWFQAIKGETRVGAGIQMLPIVGAIIGVNIVAG 372
>sp|Q8AYS8|KCMA1_CHICK Calcium-activated potassium channel subunit
alpha-1 OS=Gallus gallus OX=9031 GN=KCNMA1 PE=1 SV=2
Length=1137
Score = 37.8 bits (86), Expect = 0.43, Method: Composition-based stats.
Identities = 34/210 (16%), Positives = 64/210 (30%), Gaps = 22/210 (10%)
Query 94 LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQ 153
L + FI++ + + S T +++ + F ++
Sbjct 151 LVIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK--- 198
Query 154 KNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
LW + +V V +S+ + R LR L+Q S +++ L
Sbjct 199 --LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQ-----FLNIL 251
Query 214 PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTAN 273
S+ L+ + + T AG + FQN + V L
Sbjct 252 KTSNSIKLVNLCSIFISTWLTA---AGFIHLVENSGDPWENFQNNQQLTYWECVYLLMVT 308
Query 274 NPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
V F+VF ++G L +
Sbjct 309 MSTVGYGDVYAKTTLGRLFMVFFILGGLAM 338
>sp|Q0P583|KCNV1_BOVIN Potassium voltage-gated channel subfamily
V member 1 OS=Bos taurus OX=9913 GN=KCNV1 PE=2 SV=2
Length=503
Score = 37.0 bits (84), Expect = 0.62, Method: Composition-based stats.
Identities = 38/276 (14%), Positives = 91/276 (33%), Gaps = 23/276 (8%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 115 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 174
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
E+ + P + L+ F + + ++V++ +
Sbjct 175 EDQESQHESEQDFSQGRCPTIRQKLWNILEKPGSCTAARIFGVISIIFVAVSIVNMAL-- 232
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ D +L IL V I ++ E +L+ + R F + ++
Sbjct 233 ---MSAELSWLDPQLLEILEYVCISWFTGEFVLRFLCVRDR-------CRFLRKVPNIID 282
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+L I + L + L ++ R++ +L + R LR++ + + S +
Sbjct 283 LLAILPFYITLLVESLSGSQTTQ--ELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGM 340
Query 574 GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ Q G +L+ F +GI++F V
Sbjct 341 TITQCYEEVGLLLL-----FLSVGISIFSTVEYFAE 371
>sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation channel
subfamily M member 2 OS=Mus musculus OX=10090 GN=Trpm2
PE=1 SV=2
Length=1506
Score = 37.4 bits (85), Expect = 0.65, Method: Composition-based stats.
Identities = 28/166 (17%), Positives = 54/166 (33%), Gaps = 19/166 (11%)
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM------- 484
F +I N++S FL L A VL + +++ + L
Sbjct 786 RAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLFSLVCEETRQLF 845
Query 485 -------LLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGL 537
L+K+ +L Y S N D ++ +V L L + +
Sbjct 846 YDPDGCGLMKMASL----YFSDFWNKLDVGAILLFIVGLTCRLIPATLYPGRIILSLDFI 901
Query 538 LSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
+ + + + +II ++M V + L + +FG
Sbjct 902 MFCLRLMHIFTISKTLGP-KIIIVKRMMKDVFFFLFLLAVWVVSFG 946
>sp|Q9TU34|ITPR1_BOVIN Inositol 1,4,5-trisphosphate-gated calcium
channel ITPR1 OS=Bos taurus OX=9913 GN=ITPR1 PE=1 SV=1
Length=2709
Score = 37.4 bits (85), Expect = 0.69, Method: Composition-based stats.
Identities = 38/266 (14%), Positives = 84/266 (32%), Gaps = 40/266 (15%)
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRML- 547
L +L NV + ++ ++ V T + LL L L
Sbjct 2307 VGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLXLLICAMGLF 2366
Query 548 --NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVI 605
++ + + V +V +++ + +++ Y+F+I+G F+
Sbjct 2367 VHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILMAVLALILVYLFSIVGYLFFKDDF 2426
Query 606 VAL------------------------------PGNSSLAPANGSAPCGSFEQLEYWANN 635
+ G + +PA + E + +
Sbjct 2427 ILEVDRLPNETSLPEASESLASEFLYSDVCRVETGENCSSPAPKEELVPAEETEQDKEHT 2486
Query 636 FDDFAAALVTLWN--LMVVNNWQVFLDAYRRYSGPWSK--IYFVLWWLVSSVIWVNLFLA 691
+ +VT+ + L L + ++ IY +L++ + +I +NL
Sbjct 2487 CETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFG 2546
Query 692 LILENFLHKWDPRSHLQPLAGTPEAT 717
+I++ F D RS Q + T
Sbjct 2547 VIIDTF---ADLRSEKQKKEEILKTT 2569
>sp|F1LMY4|RYR1_RAT Ryanodine receptor 1 OS=Rattus norvegicus
OX=10116 GN=Ryr1 PE=1 SV=1
Length=5035
Score = 37.4 bits (85), Expect = 0.74, Method: Composition-based stats.
Identities = 34/217 (16%), Positives = 71/217 (33%), Gaps = 30/217 (14%)
Query 506 GLLTVVLLVL---EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
GLLT ++ + +I V + ++SL N L I +
Sbjct 4761 GLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLL--GHYNNFFFAAHLLDIAMGV 4818
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
K + + S+V + + G+L VV Y++ ++ N FR +
Sbjct 4819 KTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR-KFYNKSEDEDEPDMKCDDM 4877
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVV-NNWQVFLDAYRRYSGPWSKIYFVLWWLVS 681
+ L+++ V D +G ++Y V++ +
Sbjct 4878 MTCY-------------------LFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF 4918
Query 682 SVIWVNLFLALI----LENFLHKWDPRSHLQPLAGTP 714
+ + LA+I ++ F D + ++ T
Sbjct 4919 FFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK 4955
>sp|P17972|KCNAW_DROME Potassium voltage-gated channel protein
Shaw OS=Drosophila melanogaster OX=7227 GN=Shaw PE=2 SV=1
Length=498
Score = 37.0 bits (84), Expect = 0.76, Method: Composition-based stats.
Identities = 30/163 (18%), Positives = 59/163 (36%), Gaps = 14/163 (9%)
Query 127 SVEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVS------LSLV 179
+E +C F ++ V+ F K+ + + + +D + +
Sbjct 233 YIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENAD 292
Query 180 CHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFA 239
E I R++R F L ++SS +K ++ R S E+ + L + + +F
Sbjct 293 ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASL------ 346
Query 240 GGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAY 282
+ F ++P L LV +TT D+ Y
Sbjct 347 -VYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTY 388
Score = 35.9 bits (81), Expect = 1.8, Method: Composition-based stats.
Identities = 34/275 (12%), Positives = 80/275 (29%), Gaps = 26/275 (9%)
Query 333 GTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
+ + S+ V Q L VL ++ LD+ +
Sbjct 87 EELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFG------ 140
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF 452
F++ + + S +E PR + +++S C+
Sbjct 141 ---FEEDYYKGTISWWQEMKPR---IWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLK 194
Query 453 LVLDA----------DVLPAERDDFILGILNCVFIVYYLLEMLLK-VFALGLRGYLSYPS 501
D F+ I ++ +E + F +
Sbjct 195 THPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSP 254
Query 502 NVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPS 561
N ++ + + V ++ I+TL+ Y L D+ +++ + R ++
Sbjct 255 NKWEFIKSSVNIIDYIATLSFYIDLVLQ---RFASHLENADILEFFSIIRIMRLFKLTRH 311
Query 562 MKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAII 596
+ ++ T + + LV+ +FA +
Sbjct 312 SSGLKILIQTFRASAKELTLLVFFLVLGIVIFASL 346
>sp|Q8NET8|TRPV3_HUMAN Transient receptor potential cation channel
subfamily V member 3 OS=Homo sapiens OX=9606 GN=TRPV3 PE=1
SV=2
Length=790
Score = 37.0 bits (84), Expect = 0.86, Method: Composition-based stats.
Identities = 38/229 (17%), Positives = 87/229 (38%), Gaps = 45/229 (20%)
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
L+ LS F + VL++L + +Y + + +V ++L +
Sbjct 513 LQSILSDAWFHFVFFIQAVLVILSV---FLYLFAYKEYLACLVLAMALGWANMLYYT--- 566
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R SM + +V+ V+ + ++ F + +V F G+ L +I P ++
Sbjct 567 ----RGFQSMGMYSVMIQKVI--LHDVLKFLFVYIVFLLGF---GVAL-ASLIEKCPKDN 616
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ GS F+ A++ L+ L + D + + + +
Sbjct 617 KDCSSYGS------------------FSDAVLELFKLTIGLG-----DLNIQQNSKYPIL 653
Query 673 YF---VLWWLVSSVIWVNLFLALI---LENFLHKWDPRSHLQPLAGTPE 715
+ + + +++ V+ +N+ +AL+ +EN + + LQ E
Sbjct 654 FLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILE 702
>sp|Q9NA13|IPLA_DICDI Inositol 1,4,5-trisphosphate receptor-like
protein A OS=Dictyostelium discoideum OX=44689 GN=iplA PE=2
SV=1
Length=3177
Score = 37.0 bits (84), Expect = 0.92, Method: Composition-based stats.
Identities = 13/67 (19%), Positives = 30/67 (45%), Gaps = 6/67 (9%)
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGT------PEATYQMTVELL 725
++ V +++V S+I +N+ L +I++ F D R+ + E +
Sbjct 2995 VFNVAFYVVISLILLNVILGIIVDTFGQLRDQRAETEDYKSNVCFICSIERETFQKNSIE 3054
Query 726 FRDILEE 732
F+ +E+
Sbjct 3055 FKKHIED 3061
Score = 35.5 bits (80), Expect = 2.7, Method: Composition-based stats.
Identities = 29/166 (17%), Positives = 58/166 (35%), Gaps = 25/166 (15%)
Query 189 LLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQD 248
F N+ + LK I + + +G+ + + L ++F + F +DD +
Sbjct 2870 AFHIFQFSLNTKALSLVLKAITMNKKTLLVMGVFILQAIYLLSIFSFVWFQEHYKDDDSE 2929
Query 249 RERLTYFQNLPESLT-------SLLVLL-----------TTANNPDVMIPAYSKN----- 285
+ Q +L L+ + T + + P + N
Sbjct 2930 YMCGSLLQCFITNLYYGVPSQGQLIQFIKYNFPNNYLNTTDSTGSPTLEPIKTSNTVSAR 2989
Query 286 -RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRR 330
+ +F + F V+ SL L+N++ II F G L + +
Sbjct 2990 IIGWTVFNVAFYVVISLILLNVILGIIVDTF-GQLRDQRAETEDYK 3034
>sp|Q4R6N0|TPTE2_MACFA Phosphatidylinositol 3,4,5-trisphosphate
3-phosphatase TPTE2 OS=Macaca fascicularis OX=9541 GN=TPTE2
PE=2 SV=1
Length=566
Score = 36.6 bits (83), Expect = 0.92, Method: Composition-based stats.
Identities = 21/126 (17%), Positives = 54/126 (43%), Gaps = 3/126 (2%)
Query 397 QKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLD 456
+ + L + V++ Y + + + + + F G + L ++ + L+ +
Sbjct 101 KSMLERLSKFEVEDAENVASYDTKIKKIVRSIVSSFAFGIFGVFLVLLDVTLLLADLIFN 160
Query 457 ADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLE 516
L + ++ +++L+++LL+VF G + Y S NV D + V L+++
Sbjct 161 DSKLYIP---LVYRSISLAIALFFLMDVLLRVFVEGRQHYFSDLLNVLDTAIIVTPLLVD 217
Query 517 ISTLAV 522
+ +
Sbjct 218 VVYIFF 223
>sp|E9PZQ0|RYR1_MOUSE Ryanodine receptor 1 OS=Mus musculus OX=10090
GN=Ryr1 PE=1 SV=1
Length=5035
Score = 37.0 bits (84), Expect = 0.93, Method: Composition-based stats.
Identities = 34/217 (16%), Positives = 71/217 (33%), Gaps = 30/217 (14%)
Query 506 GLLTVVLLVL---EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSM 562
GLLT ++ + +I V + ++SL N L I +
Sbjct 4761 GLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLL--GHYNNFFFAAHLLDIAMGV 4818
Query 563 KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAP 622
K + + S+V + + G+L VV Y++ ++ N FR +
Sbjct 4819 KTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR-KFYNKSEDEDEPDMKCDDM 4877
Query 623 CGSFEQLEYWANNFDDFAAALVTLWNLMVV-NNWQVFLDAYRRYSGPWSKIYFVLWWLVS 681
+ L+++ V D +G ++Y V++ +
Sbjct 4878 MTCY-------------------LFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF 4918
Query 682 SVIWVNLFLALI----LENFLHKWDPRSHLQPLAGTP 714
+ + LA+I ++ F D + ++ T
Sbjct 4919 FFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK 4955
>sp|Q8K424|TRPV3_MOUSE Transient receptor potential cation channel
subfamily V member 3 OS=Mus musculus OX=10090 GN=Trpv3
PE=1 SV=2
Length=791
Score = 36.6 bits (83), Expect = 0.94, Method: Composition-based stats.
Identities = 36/229 (16%), Positives = 85/229 (37%), Gaps = 45/229 (20%)
Query 493 LRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV 552
L+ LS F + VL++L + +Y + + +V ++L +
Sbjct 513 LQSILSDAWFHFVFFVQAVLVILSV---FLYLFAYKEYLACLVLAMALGWANMLYYT--- 566
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R SM + +V+ V+ + ++ F + ++ F G+ L +I +
Sbjct 567 ----RGFQSMGMYSVMIQKVI--LHDVLKFLFVYILFLLGF---GVAL-ASLIEKCSKDK 616
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ GS F+ A++ L+ L + D + + + +
Sbjct 617 KDCSSYGS------------------FSDAVLELFKLTIGLG-----DLNIQQNSTYPIL 653
Query 673 YF---VLWWLVSSVIWVNLFLALI---LENFLHKWDPRSHLQPLAGTPE 715
+ + + +++ V+ +N+ +AL+ +EN + + LQ E
Sbjct 654 FLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILE 702
>sp|P11881|ITPR1_MOUSE Inositol 1,4,5-trisphosphate-gated calcium
channel ITPR1 OS=Mus musculus OX=10090 GN=Itpr1 PE=1 SV=2
Length=2749
Score = 37.0 bits (84), Expect = 0.99, Method: Composition-based stats.
Identities = 41/266 (15%), Positives = 87/266 (33%), Gaps = 40/266 (15%)
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
L +L NV + ++ ++ V T + LL L L
Sbjct 2347 VGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLF 2406
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG---ILVVVYYVFAIIGINLFRGVI 605
+ F L + + + + + + +N R+ + +++ Y+F+I+G F+
Sbjct 2407 VHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDF 2466
Query 606 VALPG---NSSLAPANGSAPCGSF---------------------------EQLEYWANN 635
+ N + P G + F E + +
Sbjct 2467 ILEVDRLPNETAVPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPAEETEQDKEHT 2526
Query 636 FDDFAAALVTLWN--LMVVNNWQVFLDAYRRYSGPWSK--IYFVLWWLVSSVIWVNLFLA 691
+ +VT+ + L L + ++ IY +L++ + +I +NL
Sbjct 2527 CETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFG 2586
Query 692 LILENFLHKWDPRSHLQPLAGTPEAT 717
+I++ F D RS Q + T
Sbjct 2587 VIIDTF---ADLRSEKQKKEEILKTT 2609
>sp|Q99J21|MCLN1_MOUSE Mucolipin-1 OS=Mus musculus OX=10090 GN=Mcoln1
PE=1 SV=1
Length=580
Score = 36.6 bits (83), Expect = 1.00, Method: Composition-based stats.
Identities = 30/245 (12%), Positives = 76/245 (31%), Gaps = 39/245 (16%)
Query 499 YPSNVFDGL--LTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFL 556
+ + ++L+ ++ T++ + + + +L+ +
Sbjct 343 SLWERLEFVNGWYILLVTSDVLTISGTVMKIGIEAKNLASYDVCSILLGTSTLLVWVGVI 402
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
R + ++ +T+ + ++ F + V+Y + F G IV P +
Sbjct 403 RYLTFFHKYNILIATLRVALPSVMRFCCCVAVIYLGYC------FCGWIVLGPYHVKFRS 456
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGP------WS 670
+ + L++L+ ++ V A + G +S
Sbjct 457 LSMVSE----------------------CLFSLINGDDMFVTFAAMQAQQGHSSLVWLFS 494
Query 671 KIYFVLWWLVSSVIWVNLFLALIL---ENFLHKWDPRSHLQPLAGTPEATYQMTVELLFR 727
++Y + + + ++LF+ALI + H + L E FR
Sbjct 495 QLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGTGTEKSELQAYIEQCQDSPTSGKFR 554
Query 728 DILEE 732
Sbjct 555 RGSGS 559
>sp|Q5RC10|KCNV1_PONAB Potassium voltage-gated channel subfamily
V member 1 OS=Pongo abelii OX=9601 GN=KCNV1 PE=2 SV=1
Length=500
Score = 36.6 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 37/276 (13%), Positives = 92/276 (33%), Gaps = 23/276 (8%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 112 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 171
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
E+ + P + L+ F + + + +++++ +
Sbjct 172 EDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMAL-- 229
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ D +L IL V I ++ E +L+ + R F + ++
Sbjct 230 ---MSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDR-------CRFLRKVPNIID 279
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+L I + L + L ++ R++ +L + R LR++ + + S +
Sbjct 280 LLAILPFYITLLVESLSGSQTTQ--ELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGM 337
Query 574 GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ Q G +L+ F +GI++F V
Sbjct 338 TITQCYEEVGLLLL-----FLSVGISIFSTVEYFAE 368
>sp|Q9GKU7|KCNV1_MACFA Potassium voltage-gated channel subfamily
V member 1 OS=Macaca fascicularis OX=9541 GN=KCNV1 PE=2 SV=1
Length=500
Score = 36.6 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 37/276 (13%), Positives = 92/276 (33%), Gaps = 23/276 (8%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 112 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 171
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
E+ + P + L+ F + + + +++++ +
Sbjct 172 EDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMAL-- 229
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ D +L IL V I ++ E +L+ + R F + ++
Sbjct 230 ---MSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDR-------CRFLRKVPNIID 279
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+L I + L + L ++ R++ +L + R LR++ + + S +
Sbjct 280 LLAILPFYITLLVESLSGSQTTQ--ELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGM 337
Query 574 GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ Q G +L+ F +GI++F V
Sbjct 338 TITQCYEEVGLLLL-----FLSVGISIFSTVEYFAE 368
>sp|Q6PIU1|KCNV1_HUMAN Potassium voltage-gated channel subfamily
V member 1 OS=Homo sapiens OX=9606 GN=KCNV1 PE=1 SV=2
Length=500
Score = 36.6 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 37/276 (13%), Positives = 92/276 (33%), Gaps = 23/276 (8%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 112 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 171
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
E+ + P + L+ F + + + +++++ +
Sbjct 172 EDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMAL-- 229
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLL 513
+ D +L IL V I ++ E +L+ + R F + ++
Sbjct 230 ---MSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDR-------CRFLRKVPNIID 279
Query 514 VLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL 573
+L I + L + L ++ R++ +L + R LR++ + + S +
Sbjct 280 LLAILPFYITLLVESLSGSQTTQ--ELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGM 337
Query 574 GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ Q G +L+ F +GI++F V
Sbjct 338 TITQCYEEVGLLLL-----FLSVGISIFSTVEYFAE 368
>sp|Q90ZC7|KCMA1_XENLA Calcium-activated potassium channel subunit
alpha-1 OS=Xenopus laevis OX=8355 GN=kcnma1 PE=2 SV=1
Length=1196
Score = 36.6 bits (83), Expect = 1.0, Method: Composition-based stats.
Identities = 36/227 (16%), Positives = 71/227 (31%), Gaps = 26/227 (11%)
Query 81 VCQRTLSFTIFLI----LFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVF 136
+ R L T+F + L + FI++ + + S T +++ + F
Sbjct 143 LTGRVLVVTVFALSIGALMIYFIDSSNPIESCQ---------NFYKDFTLQIDMAFNIFF 193
Query 137 AADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL 196
++ LW + +V V +S+ + R LR L+
Sbjct 194 LLYFGLRFIAANDK-----LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLI 248
Query 197 QNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQ 256
Q S +++ L S+ L+ + + T AG + F+
Sbjct 249 QFSEILQ-----FLNILKTSNSIKLVNLCSIFISTWLTA---AGFIHLVENSGDPWRNFE 300
Query 257 NLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL 303
N + + L V F+VF ++G L +
Sbjct 301 NSQDLSYWECMYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAM 347
>sp|P21817|RYR1_HUMAN Ryanodine receptor 1 OS=Homo sapiens OX=9606
GN=RYR1 PE=1 SV=3
Length=5038
Score = 37.0 bits (84), Expect = 1.0, Method: Composition-based stats.
Identities = 26/172 (15%), Positives = 56/172 (33%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I +K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4807 NFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR-KFYN 4865
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-NNWQVFLDAYRRYS 666
+ + L+++ V D +
Sbjct 4866 KSEDEDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4906
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI----LENFLHKWDPRSHLQPLAGTP 714
G ++Y V++ + + + LA+I ++ F D + ++ T
Sbjct 4907 GDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK 4958
>sp|P16960|RYR1_PIG Ryanodine receptor 1 OS=Sus scrofa OX=9823
GN=RYR1 PE=2 SV=2
Length=5035
Score = 37.0 bits (84), Expect = 1.0, Method: Composition-based stats.
Identities = 26/172 (15%), Positives = 56/172 (33%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I +K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4804 NFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR-KFYN 4862
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-NNWQVFLDAYRRYS 666
+ + L+++ V D +
Sbjct 4863 KSEDEDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4903
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI----LENFLHKWDPRSHLQPLAGTP 714
G ++Y V++ + + + LA+I ++ F D + ++ T
Sbjct 4904 GDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETK 4955
>sp|P29994|ITPR1_RAT Inositol 1,4,5-trisphosphate-gated calcium
channel ITPR1 OS=Rattus norvegicus OX=10116 GN=Itpr1 PE=1
SV=2
Length=2750
Score = 36.6 bits (83), Expect = 1.1, Method: Composition-based stats.
Identities = 41/266 (15%), Positives = 86/266 (32%), Gaps = 40/266 (15%)
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
L +L NV + ++ ++ V T + LL L L
Sbjct 2348 VGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLF 2407
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG---ILVVVYYVFAIIGINLFRGVI 605
+ F L + + + + + + +N R + +++ Y+F+I+G F+
Sbjct 2408 VHEFFYSLLLFDLVYREETLLNVIKSVTRNGRPIILTAALALILVYLFSIVGYLFFKDDF 2467
Query 606 VALPG---NSSLAPANGSAPCGSF---------------------------EQLEYWANN 635
+ N + P G + F E + +
Sbjct 2468 ILEVDRLPNETAGPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPVEETEQDKEHT 2527
Query 636 FDDFAAALVTLWN--LMVVNNWQVFLDAYRRYSGPWSK--IYFVLWWLVSSVIWVNLFLA 691
+ +VT+ + L L + ++ IY +L++ + +I +NL
Sbjct 2528 CETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFG 2587
Query 692 LILENFLHKWDPRSHLQPLAGTPEAT 717
+I++ F D RS Q + T
Sbjct 2588 VIIDTF---ADLRSEKQKKEEILKTT 2610
>sp|P11716|RYR1_RABIT Ryanodine receptor 1 OS=Oryctolagus cuniculus
OX=9986 GN=RYR1 PE=1 SV=1
Length=5037
Score = 36.6 bits (83), Expect = 1.2, Method: Composition-based stats.
Identities = 26/172 (15%), Positives = 56/172 (33%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I +K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4806 NFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR-KFYN 4864
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-NNWQVFLDAYRRYS 666
+ + L+++ V D +
Sbjct 4865 KSEDEDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4905
Query 667 GPWSKIYFVLWWLVSSVIWVNLFLALI----LENFLHKWDPRSHLQPLAGTP 714
G ++Y V++ + + + LA+I ++ F D + ++ T
Sbjct 4906 GDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK 4957
>sp|Q13507|TRPC3_HUMAN Short transient receptor potential channel
3 OS=Homo sapiens OX=9606 GN=TRPC3 PE=1 SV=4
Length=921
Score = 36.2 bits (82), Expect = 1.4, Method: Composition-based stats.
Identities = 40/309 (13%), Positives = 93/309 (30%), Gaps = 65/309 (21%)
Query 439 NLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYL-LEMLLKVFALG----- 492
+I L LV LP + V + EML+ V+ LG
Sbjct 466 FIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSE 525
Query 493 --------LRGYLSYPSNVFDGLLTVVLLVLEISTLAVY-------RLPHPGWRPEMVGL 537
R Y+ NV D + + + + + + + +
Sbjct 526 CKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSE 585
Query 538 LSLWDMTRMLNMLI-----------------------VFRFLRIIPSMKLMAVVASTVLG 574
++L + R I+P+ + + ++
Sbjct 586 VTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGR 645
Query 575 LVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWAN 634
V+++ F + ++V++ F +IG+ + + N++ S
Sbjct 646 TVKDIFKFMVLFIMVFFAF-MIGMFILYSYYLGAKVNAAFTTVEES-------------- 690
Query 635 NFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
F ++ L + V V ++ +Y + + + V+ +N+ +A+I
Sbjct 691 -FKTLFWSIFGLSEVTSV----VLKYDHKFIENIGYVLYGI-YNVTMVVVLLNMLIAMIN 744
Query 695 ENFLHKWDP 703
++ D
Sbjct 745 SSYQEIEDD 753
>sp|Q14643|ITPR1_HUMAN Inositol 1,4,5-trisphosphate-gated calcium
channel ITPR1 OS=Homo sapiens OX=9606 GN=ITPR1 PE=1 SV=3
Length=2758
Score = 36.2 bits (82), Expect = 1.6, Method: Composition-based stats.
Identities = 40/266 (15%), Positives = 87/266 (33%), Gaps = 40/266 (15%)
Query 489 FALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLN 548
L +L NV + ++ ++ V T + LL L L
Sbjct 2356 VGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLF 2415
Query 549 MLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGG---ILVVVYYVFAIIGINLFRGVI 605
+ F L + + + + + + +N R+ + +++ Y+F+I+G F+
Sbjct 2416 VHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDF 2475
Query 606 VAL------------------------------PGNSSLAPANGSAPCGSFEQLEYWANN 635
+ G + +PA + E + +
Sbjct 2476 ILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEETEQDKEHT 2535
Query 636 FDDFAAALVTLWN--LMVVNNWQVFLDAYRRYSGPWSK--IYFVLWWLVSSVIWVNLFLA 691
+ +VT+ + L L + ++ IY +L++ + +I +NL
Sbjct 2536 CETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFG 2595
Query 692 LILENFLHKWDPRSHLQPLAGTPEAT 717
+I++ F D RS Q + T
Sbjct 2596 VIIDTF---ADLRSEKQKKEEILKTT 2618
>sp|E9PTA2|TRPM2_RAT Transient receptor potential cation channel
subfamily M member 2 OS=Rattus norvegicus OX=10116 GN=Trpm2
PE=1 SV=3
Length=1507
Score = 35.9 bits (81), Expect = 1.7, Method: Composition-based stats.
Identities = 30/182 (16%), Positives = 59/182 (32%), Gaps = 19/182 (10%)
Query 416 EYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCV 475
++ LQ+ L F +I N++S FL L A VL + +
Sbjct 771 SFREKRLQALCRLARVRAFFNAPVVIFYLNILSYFAFLCLFAYVLMVDFQPSPSWCEYLI 830
Query 476 FIVYYLLEM--------------LLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLA 521
++ + L L+K+ +L Y S N D ++ + L
Sbjct 831 YLWLFSLVCEETRQLFYDPDGCGLMKMASL----YFSDFWNKLDVGAILLFIAGLTCRLI 886
Query 522 VYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRA 581
L + ++ + + + +II ++M V + L + +
Sbjct 887 PATLYPGRIILSLDFIMFCLRLMHIFTISKTLGP-KIIIVKRMMKDVFFFLFLLAVWVVS 945
Query 582 FG 583
FG
Sbjct 946 FG 947
>sp|O94759|TRPM2_HUMAN Transient receptor potential cation channel
subfamily M member 2 OS=Homo sapiens OX=9606 GN=TRPM2 PE=1
SV=2
Length=1503
Score = 35.9 bits (81), Expect = 1.7, Method: Composition-based stats.
Identities = 29/158 (18%), Positives = 53/158 (34%), Gaps = 19/158 (12%)
Query 440 LIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLL---EM-----------L 485
++ N++S FL L A VL + +++ + L EM L
Sbjct 797 VVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGL 856
Query 486 LKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTR 545
+K AL Y S N D ++ + L L + +L +
Sbjct 857 MKKAAL----YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFCLRLMH 912
Query 546 MLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFG 583
+ + +II ++M V + L + +FG
Sbjct 913 IFTISKTLGP-KIIIVKRMMKDVFFFLFLLAVWVVSFG 949
>sp|Q7Z020|TRPA1_DROME Transient receptor potential cation channel
subfamily A member 1 OS=Drosophila melanogaster OX=7227
GN=TrpA1 PE=1 SV=4
Length=1197
Score = 35.9 bits (81), Expect = 1.8, Method: Composition-based stats.
Identities = 34/258 (13%), Positives = 86/258 (33%), Gaps = 61/258 (24%)
Query 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLM 565
+L V L+ + ++ + P ++P+ G+ ++ + + + R++ ++
Sbjct 857 YILETVNLISWVLYISALVMVTPAFQPD-GGINTIHYSAASIAVF--LSWFRLLLFLQRF 913
Query 566 AVVASTVLGLVQNMRAFGGILVVV-YYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCG 624
V V+ ++ ++ +L+V + A F L N +
Sbjct 914 DQVGIYVVMFLEILQTLIKVLMVFSILIIA------FGLAFYILLSKIIDPQPNHLS--- 964
Query 625 SFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK----IYFVLWWLV 680
F + +L+ +++M+ LD Y + + + + ++
Sbjct 965 -----------FSNIPMSLLRTFSMMLGE-----LDFVGTYVNTYYRDQLKVPMTSFLIL 1008
Query 681 SSVIWV------NLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPG 734
S + + NL + L + ++ + L + +L
Sbjct 1009 SVFMILMPILLMNLLIGLAV----------GDIESV-----RRNAQLKRLAMQVVLHTEL 1053
Query 735 EDELTERLSQHPHLWLCR 752
E +L PH+WL R
Sbjct 1054 ERKL-------PHVWLQR 1064
>sp|Q8WSR4|ITPR_PATPE Inositol 1,4,5-trisphosphate receptor OS=Patiria
pectinifera OX=7594 GN=IP3R PE=1 SV=1
Length=2698
Score = 35.9 bits (81), Expect = 1.8, Method: Composition-based stats.
Identities = 52/406 (13%), Positives = 112/406 (28%), Gaps = 54/406 (13%)
Query 359 PQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ 418
+ ++V K + D + ++ + ++QK +
Sbjct 2163 AETKIKVFTKAERDDQGSKVADFFEKT--EDMFMEMKWQKKLRAQPILFLASSNMSKWSL 2220
Query 419 SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV 478
F + +F + + ++ A + GI VF
Sbjct 2221 VCFNLAVIVNLLVAFFYPFDVTTTELDHGLSMLVWLMAASLAAIVTLRRPSGIRPLVFAT 2280
Query 479 YYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLL 538
L ML+ + +F+ + ++ + L + +L
Sbjct 2281 I--LRMLIFSIGVEPTLLFLAVLTIFNKCIFILSFLGNCGLLYKGVRGIFTDMEVLYHIL 2338
Query 539 SLWDMTRML---NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAI 595
L L L ++ + V +V +++ + +++ Y+F+I
Sbjct 2339 YLIICFLGLFVHEFFYSLLLLDVVYQEDTLINVIHSVTRNWRSIAFTALLALILVYLFSI 2398
Query 596 IGINLFRGVIVA----------------LPGNSSLAPANGSAPCGSFEQLEYWANNFDDF 639
+G + V G S P + E + NN
Sbjct 2399 VGYLFLQDDFVYEVNPLRPAIATATATNKTGTSPPMPLPPESCPAGLEMEDCLKNNLSHV 2458
Query 640 AAA-------------------------LVTL-WNLMVVNNWQVFLDAYRRYSGPWSK-- 671
A + TL + + L + +
Sbjct 2459 QAKEVSYDSGIEVGTERERACETLIMYIITTLNFGVRSGGGIGDVLRSPSTREPLYMARV 2518
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEAT 717
IY +L+++V +I +NL +I++ F D RS Q + T
Sbjct 2519 IYDLLFFIVVIIIVLNLIFGVIIDTF---ADLRSEKQQKEEILKNT 2561
>sp|Q8TDD5|MCLN3_HUMAN Mucolipin-3 OS=Homo sapiens OX=9606 GN=MCOLN3
PE=1 SV=1
Length=553
Score = 35.1 bits (79), Expect = 2.7, Method: Composition-based stats.
Identities = 41/275 (15%), Positives = 95/275 (35%), Gaps = 46/275 (17%)
Query 432 YYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFAL 491
FD L L +L+ +C+ V+ L E +F F+++Y E ++
Sbjct 286 MIFDAFVILTCLVSLI-LCIRSVIRGLQLQQEFVNF--------FLLHYKKE-----VSV 331
Query 492 GLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLI 551
+ + + ++ ++ I + + + ++ +L +
Sbjct 332 SDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSY--DVCSILLGTSTMLVW---- 385
Query 552 VFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGN 611
+R + ++ T+ + N+ F ++Y + F G IV P +
Sbjct 386 -LGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYC------FCGWIVLGPYH 438
Query 612 SSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSK 671
N + C + N DD + + M ++ V+L +S+
Sbjct 439 DKFRSLNMVSECL------FSLINGDD----MFATFAKMQQKSYLVWL---------FSR 479
Query 672 IYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSH 706
IY + + + ++LF+ALI + + +
Sbjct 480 IYLYSFISLFIYMILSLFIALITDTYETIKQYQQD 514
>sp|Q9JMI9|TRPC3_RAT Short transient receptor potential channel
3 OS=Rattus norvegicus OX=10116 GN=Trpc3 PE=2 SV=4
Length=909
Score = 35.1 bits (79), Expect = 2.8, Method: Composition-based stats.
Identities = 40/331 (12%), Positives = 101/331 (31%), Gaps = 71/331 (21%)
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA-DVLPAERDDFILGILNCVF---I 477
+ + ++ + + + + VF D + + + ++ +F
Sbjct 433 CSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKT 492
Query 478 VYYL-LEMLLKVFALG-------------LRGYLSYPSNVFDGLLTVVLLVLEISTLAVY 523
+ EML+ V+ LG R Y+ NV D + + + + +
Sbjct 493 TQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAF 552
Query 524 RLPHPG-------------------------------WRPEMVGLLSLWDMTRMLNMLIV 552
W P ++S + +L
Sbjct 553 LQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAV-VLSF 611
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R I+P+ + + ++ V+++ F + ++V+ F +IG+ + + N
Sbjct 612 SRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAF-MIGMFILYSYYLGAKVNP 670
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ S F ++ L + V V ++ +
Sbjct 671 AFTTVEES---------------FKTLFWSIFGLSEVTSV----VLKYDHKFIENIGYVL 711
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
Y + + + V+ +N+ +A+I ++ D
Sbjct 712 YGI-YNVTMVVVLLNMLIAMINSSYQEIEDD 741
>sp|Q9I829|KCNA1_ONCMY Shaker-related potassium channel tsha2
OS=Oncorhynchus mykiss OX=8022 PE=2 SV=1
Length=483
Score = 35.1 bits (79), Expect = 2.9, Method: Composition-based stats.
Identities = 19/99 (19%), Positives = 39/99 (39%), Gaps = 13/99 (13%)
Query 128 VEVLCLLVFAADLSVKGYLF-GWAHFQKNLWLLGYLVVLVVSLVDWTVSL---------- 176
VE LC++ F+ + V+ F KN ++ + + + L
Sbjct 224 VETLCIVWFSFEFLVRFLSCPSKPAFFKNAMNSIDILAIAPYFITLGLELAEQQEAGSEQ 283
Query 177 --SLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL 213
SL +R+ R+ R F L ++S ++ + + S+
Sbjct 284 AMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLHASI 322
>sp|Q9QZC1|TRPC3_MOUSE Short transient receptor potential channel
3 OS=Mus musculus OX=10090 GN=Trpc3 PE=1 SV=2
Length=910
Score = 35.1 bits (79), Expect = 2.9, Method: Composition-based stats.
Identities = 40/331 (12%), Positives = 101/331 (31%), Gaps = 71/331 (21%)
Query 422 LQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDA-DVLPAERDDFILGILNCVF---I 477
+ + ++ + + + + VF D + + + ++ +F
Sbjct 434 CSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKT 493
Query 478 VYYL-LEMLLKVFALG-------------LRGYLSYPSNVFDGLLTVVLLVLEISTLAVY 523
+ EML+ V+ LG R Y+ NV D + + + + +
Sbjct 494 TQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAF 553
Query 524 RLPHPG-------------------------------WRPEMVGLLSLWDMTRMLNMLIV 552
W P ++S + +L
Sbjct 554 LQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAV-VLSF 612
Query 553 FRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNS 612
R I+P+ + + ++ V+++ F + ++V+ F +IG+ + + N
Sbjct 613 SRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAF-MIGMFILYSYYLGAKVNP 671
Query 613 SLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI 672
+ S F ++ L + V V ++ +
Sbjct 672 AFTTVEES---------------FKTLFWSIFGLSEVTSV----VLKYDHKFIENIGYVL 712
Query 673 YFVLWWLVSSVIWVNLFLALILENFLHKWDP 703
Y + + + V+ +N+ +A+I ++ D
Sbjct 713 YGI-YNVTMVVVLLNMLIAMINSSYQEIEDD 742
>sp|Q9Z0T6|PKDRE_MOUSE Polycystin family receptor for egg jelly
OS=Mus musculus OX=10090 GN=Pkdrej PE=2 SV=2
Length=2126
Score = 35.1 bits (79), Expect = 3.4, Method: Composition-based stats.
Identities = 23/195 (12%), Positives = 55/195 (28%), Gaps = 22/195 (11%)
Query 496 YLSYPSNVFDGLLTVVLLVLEISTL---------AVYRLPHPGWRPEMVGLLSLWDMTRM 546
Y+ N+ + L + +L + L P + + R+
Sbjct 1866 YIRSVYNLLNFSLKCMFALLIVLFFWKYFLATKMVQLYLADPEAFIPFHAVSRVDHFMRI 1925
Query 547 ----LNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFR 602
L L + + LR + + + + + ++ + +++ G +F
Sbjct 1926 ILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVAFGYLVFG 1985
Query 603 GVIVALPGNSSLAPANGSAPCGSFEQLEYWAN------NFDDFAAALVTLWNLMVVNNWQ 656
S +F+ E+ N F ++ ++ +
Sbjct 1986 QHEWNYSNMIHATQTIFSYCVSAFQNTEFSGNKVLGVLFLSSFMLVMICIFINLFQA--- 2042
Query 657 VFLDAYRRYSGPWSK 671
V L AY P +
Sbjct 2043 VILSAYDEMKQPVYE 2057
>sp|A3LTB7|ALG3_PICST Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
OS=Scheffersomyces stipitis (strain ATCC
58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) OX=322104
GN=ALG3 PE=3 SV=2
Length=477
Score = 34.7 bits (78), Expect = 3.4, Method: Composition-based stats.
Identities = 42/329 (13%), Positives = 105/329 (32%), Gaps = 28/329 (9%)
Query 276 DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
++ + + + FI+F +G+ F++ ++ + + + K T + +
Sbjct 23 ELTLKNVLGDIVNGVHFIIFDPLGNRFVVPVIILLTSIITKVIITKVPYTEIDFVTYMQQ 82
Query 336 ---AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLS 392
+ G V P +Q+ Q + ++ + +G ++ +
Sbjct 83 IQLVNQGEIDYAEISGDT---GPIVYPAGFVQIYQWLYSQTNGGADIATGQSIFGYLMTA 139
Query 393 AEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVF 452
F + + P + L ++ L+ Y + A +V + VF
Sbjct 140 TVVFVCVAYTMS-------PTTKPWVLFLLLGSKRLYSIYVLRLFNDCFTTAAMVGVTVF 192
Query 453 LVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLR------GYLSYPSNVFDG 506
L FI + V + + + +K+ AL Y N+
Sbjct 193 --LQQGSYWYSTSSFISFLFAIVGADLFSIAISIKMNALLYLPAVVIIAYFLVGENIL-L 249
Query 507 LLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMA 566
V+ +V + L ++ P + E + + N F +
Sbjct 250 FAIVLAIVPLVQILVGWKFLLPLFDDEAASQIRWNYINNAFNFGRKF----LFKWTVNWR 305
Query 567 VV--ASTVLGLVQNMRAFGGILVVVYYVF 593
+ + + + G I+V+++++F
Sbjct 306 FIGEETFLSDKFSILLMGGHIVVLLFFIF 334
>sp|B7ZC96|KCMA1_DANRE Calcium-activated potassium channel subunit
alpha-1a OS=Danio rerio OX=7955 GN=kcnma1a PE=1 SV=1
Length=1184
Score = 34.7 bits (78), Expect = 3.7, Method: Composition-based stats.
Identities = 30/185 (16%), Positives = 59/185 (32%), Gaps = 14/185 (8%)
Query 124 LTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEP 183
T +++ + F ++ LW + +V V +S+ +
Sbjct 167 FTLQIDMAFNVFFLLYFGLRFIAANDK-----LWFWLEVNSVVDFFTVPPVFVSVYLNRS 221
Query 184 LRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQ 243
R LR L+Q S +++ L S+ L+ + + T AG
Sbjct 222 WLGLRFLRALRLIQFSEILQ-----FLNILKTSNSIKLVNLCSIFISTWLTA---AGFIH 273
Query 244 DDGQDRERLTYFQN-LPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLF 302
+ FQN P S + LL + Y++ +F + F + G
Sbjct 274 LVENSGDPWENFQNSQPLSYWECVYLLMVTMSTVGYGDVYARTTLGRLFMVFFILGGLAM 333
Query 303 LMNLL 307
+ +
Sbjct 334 FASYV 338
>sp|A2AGL3|RYR3_MOUSE Ryanodine receptor 3 OS=Mus musculus OX=10090
GN=Ryr3 PE=1 SV=1
Length=4863
Score = 34.7 bits (78), Expect = 4.1, Method: Composition-based stats.
Identities = 24/172 (14%), Positives = 52/172 (30%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4632 NFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFR-KFYN 4690
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-----NNWQVFLDAY 662
+ + L+++ V D
Sbjct 4691 KSEDDDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4731
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
+ ++ + ++ VI + + LI++ F D + ++ T
Sbjct 4732 GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETK 4783
>sp|Q15413|RYR3_HUMAN Ryanodine receptor 3 OS=Homo sapiens OX=9606
GN=RYR3 PE=1 SV=3
Length=4870
Score = 34.7 bits (78), Expect = 4.2, Method: Composition-based stats.
Identities = 24/172 (14%), Positives = 52/172 (30%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4639 NFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFR-KFYN 4697
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-----NNWQVFLDAY 662
+ + L+++ V D
Sbjct 4698 KSEDDDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4738
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
+ ++ + ++ VI + + LI++ F D + ++ T
Sbjct 4739 GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETK 4790
>sp|Q9TS33|RYR3_RABIT Ryanodine receptor 3 OS=Oryctolagus cuniculus
OX=9986 GN=RYR3 PE=1 SV=1
Length=4872
Score = 34.7 bits (78), Expect = 4.3, Method: Composition-based stats.
Identities = 24/172 (14%), Positives = 52/172 (30%), Gaps = 25/172 (15%)
Query 548 NMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVA 607
N L I K + + S+V + + G+L VV Y++ ++ N FR
Sbjct 4641 NFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFR-KFYN 4699
Query 608 LPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVV-----NNWQVFLDAY 662
+ + L+++ V D
Sbjct 4700 KSEDDDEPDMKCDDMMTCY-------------------LFHMYVGVRAGGGIGDEIEDPA 4740
Query 663 RRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTP 714
+ ++ + ++ VI + + LI++ F D + ++ T
Sbjct 4741 GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETK 4792
>sp|Q9NZM6|PK2L2_HUMAN Polycystin-2-like protein 2 OS=Homo sapiens
OX=9606 GN=PKD2L2 PE=1 SV=2
Length=624
Score = 34.3 bits (77), Expect = 4.4, Method: Composition-based stats.
Identities = 39/284 (14%), Positives = 98/284 (35%), Gaps = 50/284 (18%)
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNV--------------FDGLLTVVLLVL 515
I C+F+ + + + K+ Y N F+ V + +L
Sbjct 286 EITFCIFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLL 344
Query 516 EISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGL 575
+ L + + + ++ + + + I K M+ ++ST+
Sbjct 345 -LGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRC 403
Query 576 VQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN 635
V+++ F + ++++ +A +G +F + ++
Sbjct 404 VKDIVGFAIMFFIIFFAYAQLGFLVFGSQV----------------------------DD 435
Query 636 FDDFAAALVTLWNLMVVN-NWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALIL 694
F F ++ + +++ + N+ A IYF+ + + +N+FLA+I
Sbjct 436 FSTFQNSIFAQFRIVLGDFNFAGIQQANPILGP----IYFITFIFFVFFVLLNMFLAIIN 491
Query 695 ENFLHKWDPRSHLQPLAGTP-EATYQMTVELLFRDILEEPGEDE 737
+ + S + L + Q +L + L++ +DE
Sbjct 492 DTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDE 535
>sp|Q9W0T5|PYX_DROME Transient receptor potential channel pyrexia
OS=Drosophila melanogaster OX=7227 GN=pyx PE=2 SV=2
Length=956
Score = 34.7 bits (78), Expect = 4.5, Method: Composition-based stats.
Identities = 25/127 (20%), Positives = 46/127 (36%), Gaps = 9/127 (7%)
Query 577 QNMRAFGGILV---VVYYV--FAIIGI--NLFRGVIVALPGNSSLAPANGSAPCGSFEQL 629
++ A +LV ++ V F I G+ +F V V A SF L
Sbjct 598 HHVAAIVILLVWLELMMLVGRFPIFGVYVQMFTKVAVNFAKFLLAYICLLVAFGLSFAVL 657
Query 630 EYWANNFDDFAAALVTLWNLMVVN-NWQVFLDAYRRYSGPWS-KIYFVLWWLVSSVIWVN 687
F++ + + +M ++ P + I F+ + L+ +VI N
Sbjct 658 FNDYPAFENITWSFLKSITMMSGELEFEDIFYGDYAVKFPVTAHIIFLSFVLLVTVILTN 717
Query 688 LFLALIL 694
L + L +
Sbjct 718 LMVGLAV 724
>sp|F6RG56|MCLN3_CALJA Mucolipin-3 OS=Callithrix jacchus OX=9483
GN=MCOLN3 PE=1 SV=1
Length=553
Score = 34.3 bits (77), Expect = 4.6, Method: Composition-based stats.
Identities = 40/268 (15%), Positives = 91/268 (34%), Gaps = 46/268 (17%)
Query 430 GHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVF 489
FD L L +L+ +C+ V+ L E +F L K
Sbjct 284 NMMIFDAFVILTCLVSLI-LCIRSVISGLQLQQEFVNFFLLHYK-------------KDV 329
Query 490 ALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNM 549
++ + + + ++ ++ I + + + ++ +L +
Sbjct 330 SVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSY--DVCSILLGTSTMLVW-- 385
Query 550 LIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+R + ++ T+ + N+ F ++Y + F G IV P
Sbjct 386 ---LGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYC------FCGWIVLGP 436
Query 610 GNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPW 669
++ N + C + N DD + + M ++ V+L +
Sbjct 437 YHNKFRSLNMVSECL------FSLINGDD----MFATFAKMQQKSYLVWL---------F 477
Query 670 SKIYFVLWWLVSSVIWVNLFLALILENF 697
S+IY + + + ++LF+ALI + +
Sbjct 478 SRIYLYSFISLFIYMILSLFIALITDTY 505
>sp|Q55GH9|GEFW_DICDI Ras guanine nucleotide exchange factor W
OS=Dictyostelium discoideum OX=44689 GN=gefW PE=2 SV=1
Length=1172
Score = 34.7 bits (78), Expect = 4.7, Method: Composition-based stats.
Identities = 27/196 (14%), Positives = 73/196 (37%), Gaps = 10/196 (5%)
Query 405 RSVVKEHPPRPEYQ--SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPA 462
+S + E + + ++ +L +I V ++ + +
Sbjct 256 KSFSPRKKRKKENKIIRRIRRWMTWVISSNI--WLTIMIISIIFVLFIDDIIGASGSPSS 313
Query 463 ERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAV 522
D+ + + C I ++ ++++L +F + D L++++ +V +I
Sbjct 314 NAIDYSIMAVKCSIIGFFSIDIILNLFCFQQEYFPGTIVFWLD-LISLISIVTDIHHFQN 372
Query 523 YRLPHPGWRPEMVGLLSLWDMTRMLNMLIVF--RFLR--IIPSMKLMAVVASTVLGLVQN 578
Y ++ + ++++ RFLR +PS + + V AS + +
Sbjct 373 YYANLVLSITVNTRIIRICGSFIRISLISTLYNRFLRKQTLPS-EGLEVEASKLGDKLIR 431
Query 579 MRAFGGILVVVYYVFA 594
+ +L+ + +FA
Sbjct 432 LTTNKIVLLALAVLFA 447
>sp|Q8BZN2|KCNV1_MOUSE Potassium voltage-gated channel subfamily
V member 1 OS=Mus musculus OX=10090 GN=Kcnv1 PE=2 SV=2
Length=503
Score = 33.9 bits (76), Expect = 5.9, Method: Composition-based stats.
Identities = 40/277 (14%), Positives = 95/277 (34%), Gaps = 25/277 (9%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 115 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 174
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
++ + P + L+ F + + ++V++ + +
Sbjct 175 DDQESQHESEQDFSKGPCPTVRQKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMAL-M 233
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG-LRGYLSYPSNVFDGLLTVVL 512
+ L + +L IL V I ++ E +L+ + +L N+ D L
Sbjct 234 SAELSWLNLQ----LLEILEYVCISWFTGEFVLRFLCVKDRCHFLRKVPNIIDLL----A 285
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ TL V L E L ++ R++ +L + R LR++ + + S
Sbjct 286 ILPFYITLLVESLSGSHTTQE------LENVGRLVQVLRLLRALRMLKLGRHSTGLRSLG 339
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ + Q G +L+ F +GI++F +
Sbjct 340 MTITQCYEEVGLLLL-----FLSVGISIFSTIEYFAE 371
>sp|P55297|MANB_PIRSP Mannan endo-1,4-beta-mannosidase B OS=Piromyces
sp. OX=45796 GN=MANB PE=2 SV=1
Length=571
Score = 33.9 bits (76), Expect = 5.9, Method: Composition-based stats.
Identities = 8/65 (12%), Positives = 21/65 (32%), Gaps = 5/65 (8%)
Query 579 MRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDD 638
M + +L +++VF+ F + N L + + F++
Sbjct 1 MNSLSLLLFCIFFVFST-----FAKKVYYEAENGKLDGVTVYKSDLTGFSGTGYVGRFEN 55
Query 639 FAAAL 643
++
Sbjct 56 PGNSV 60
>sp|A0A3T0QHT2|PVHT_TALVA Varicidin biosynthesis cluster MFS-type
transporer OS=Talaromyces variabilis OX=28576 GN=mfs PE=1
SV=1
Length=547
Score = 33.9 bits (76), Expect = 6.0, Method: Composition-based stats.
Identities = 23/122 (19%), Positives = 36/122 (30%), Gaps = 17/122 (14%)
Query 73 LYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLC 132
+ L + +FL F+ PS GL + ++ L
Sbjct 178 RATWRWCFWINLPLGGVTAVAVFL-FVRLPSP----------QGGATTFLGLLQKLDALG 226
Query 133 LLVFAADLSVKGYLFGWA--HFQKNLW-LLGYLVVLVVSLVDWTVSL---SLVCHEPLRI 186
+ + W + N W ++ LV+ V LV W PLRI
Sbjct 227 TCILMPLIICLLLALQWGGTTYAWNSWRVVLCLVLFTVLLVAWLYVQYRQGDGGALPLRI 286
Query 187 RR 188
R
Sbjct 287 VR 288
>sp|P97557|KCNV1_RAT Potassium voltage-gated channel subfamily
V member 1 OS=Rattus norvegicus OX=10116 GN=Kcnv1 PE=1 SV=1
Length=503
Score = 33.9 bits (76), Expect = 6.3, Method: Composition-based stats.
Identities = 40/277 (14%), Positives = 95/277 (34%), Gaps = 25/277 (9%)
Query 338 FEVLSSMVGEGGAFPQAVGVKPQNLLQV--LQKVQLDSSHKQAMMEKVRSYGSVLL--SA 393
+ + G Q + +Q + ++ +DS + + ++
Sbjct 115 YVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDT 174
Query 394 EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFL 453
++ + P + L+ F + + ++V++ + +
Sbjct 175 DDQESQHESEQDFSQGPCPTVRQKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMAL-M 233
Query 454 VLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALG-LRGYLSYPSNVFDGLLTVVL 512
+ L + +L IL V I ++ E +L+ + +L N+ D L
Sbjct 234 SAELSWLNLQ----LLEILEYVCISWFTGEFILRFLCVKDRCHFLRKVPNIIDLL----A 285
Query 513 LVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTV 572
++ TL V L E L ++ R++ +L + R LR++ + + S
Sbjct 286 ILPFYITLLVESLSGSHTTQE------LENVGRLVQVLRLLRALRMLKLGRHSTGLRSLG 339
Query 573 LGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALP 609
+ + Q G +L+ F +GI++F +
Sbjct 340 MTITQCYEEVGLLLL-----FLSVGISIFSTIEYFAE 371
>sp|Q60HE8|MCLN1_MACFA Mucolipin-1 OS=Macaca fascicularis OX=9541
GN=MCOLN1 PE=2 SV=1
Length=580
Score = 33.9 bits (76), Expect = 6.3, Method: Composition-based stats.
Identities = 28/203 (14%), Positives = 68/203 (33%), Gaps = 36/203 (18%)
Query 499 YPSNVFDGLLTV-VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV-FRFL 556
+ + +LLV + G + + + + + L+V +
Sbjct 343 SLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVI 402
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
R + ++ +T+ + ++ F + V+Y + F G IV P +
Sbjct 403 RYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYC------FCGWIVLGPYHVKFRS 456
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG------PWS 670
+ + L++L+ ++ V A + G +S
Sbjct 457 LSMVSE----------------------CLFSLINGDDMFVTFAAMQAQQGRSSLVWLFS 494
Query 671 KIYFVLWWLVSSVIWVNLFLALI 693
++Y + + + ++LF+ALI
Sbjct 495 QLYLYSFISLFIYMVLSLFIALI 517
>sp|Q9GZU1|MCLN1_HUMAN Mucolipin-1 OS=Homo sapiens OX=9606 GN=MCOLN1
PE=1 SV=1
Length=580
Score = 33.9 bits (76), Expect = 6.3, Method: Composition-based stats.
Identities = 28/203 (14%), Positives = 68/203 (33%), Gaps = 36/203 (18%)
Query 499 YPSNVFDGLLTV-VLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIV-FRFL 556
+ + +LLV + G + + + + + L+V +
Sbjct 343 SLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVI 402
Query 557 RIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAP 616
R + ++ +T+ + ++ F + V+Y + F G IV P +
Sbjct 403 RYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYC------FCGWIVLGPYHVKFRS 456
Query 617 ANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSG------PWS 670
+ + L++L+ ++ V A + G +S
Sbjct 457 LSMVSE----------------------CLFSLINGDDMFVTFAAMQAQQGRSSLVWLFS 494
Query 671 KIYFVLWWLVSSVIWVNLFLALI 693
++Y + + + ++LF+ALI
Sbjct 495 QLYLYSFISLFIYMVLSLFIALI 517
>sp|Q8T2Q0|ZDHC6_DICDI Putative ZDHHC-type palmitoyltransferase
6 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0275149 PE=2
SV=1
Length=698
Score = 33.9 bits (76), Expect = 7.3, Method: Composition-based stats.
Identities = 13/76 (17%), Positives = 30/76 (39%), Gaps = 2/76 (3%)
Query 221 LLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIP 280
LL I +F + + L+ G L F + +T +N+P+ ++P
Sbjct 259 LLYNIFWIIFAIL-LQLYFGFIFYHFTLIPALILFGASLTCCKLFIEPITLSNSPNPLLP 317
Query 281 AYSKNRAYAIFFIVFT 296
+ ++ + F+ +
Sbjct 318 TWM-ITSFTVSFVYYV 332
>sp|Q28558|MTR1L_SHEEP Melatonin-related receptor OS=Ovis aries
OX=9940 GN=GPR50 PE=2 SV=2
Length=575
Score = 33.9 bits (76), Expect = 7.3, Method: Composition-based stats.
Identities = 45/289 (16%), Positives = 106/289 (37%), Gaps = 36/289 (12%)
Query 437 LGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIV-YYLLEMLLKVFALG--L 493
L + A +++I V L+ ++ V+ A + L VF+V + +ML+ ++ L
Sbjct 27 LIVFMFCAMVITIVVDLIGNSMVILAVSKNKKLRNSGNVFVVSLSVADMLVAIYPYPLML 86
Query 494 RGYLSYPSNV---------FDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMT 544
++ F L+VV + I +A+ R + + + S+ +
Sbjct 87 HAMAIGGWDLSKLQCQMVGFITGLSVVGSIFNIMAIAINRYCYICHSLQYERIFSVRNTC 146
Query 545 RMLNMLIVFRFLRIIPSM-----KLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGIN 599
L + + L ++P+M + + + V N AF +V +++V ++ +
Sbjct 147 IYLAVTWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYVNN-PAFAVTIVCIHFVLPLLIVG 205
Query 600 LFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNL-------MVV 652
F V + + A + + NF + L+ + + V
Sbjct 206 -FCYVKIW-----TKVLAARDPAGQNPDNQLAEVRNFLTMF-VIFLLFAVCWCPINALTV 258
Query 653 NNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFL-ALILENFLHK 700
V ++ + +Y +++ +N + ++ ENF +
Sbjct 259 ---LVAVNPKEMAGKIPNWVYLAAYFIAYFNSCLNAVIYGVLNENFRRE 304
>sp|Q8R455|TRPM8_RAT Transient receptor potential cation channel
subfamily M member 8 OS=Rattus norvegicus OX=10116 GN=Trpm8
PE=1 SV=4
Length=1104
Score = 33.9 bits (76), Expect = 7.7, Method: Composition-based stats.
Identities = 25/158 (16%), Positives = 56/158 (35%), Gaps = 8/158 (5%)
Query 410 EHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
P +++ F F + + N++ + + +++L + IL
Sbjct 713 RKKPIDKHKKLLWYYVAF-FTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELIL 771
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
L VF+ + E + + + G Y + NV D L + + L
Sbjct 772 YAL--VFV-LFCDE-VRQWYMNG-VNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLY 826
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFL--RIIPSMKLM 565
+ L + R++++ V R L +II +++
Sbjct 827 SGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRML 864
>sp|Q8MMH3|ARMT1_PIMHY Damage-control phosphatase ARMT1 OS=Pimpla
hypochondriaca OX=135724 GN=vpr2 PE=1 SV=1
Length=488
Score = 33.5 bits (75), Expect = 7.8, Method: Composition-based stats.
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 6/100 (6%)
Query 655 WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILE----NFLHKWDPRSHLQPL 710
W LD R GP +F + L S + + A L NF + HL L
Sbjct 131 WNEHLDRQREIEGPNLSYFFTRFLLAESYTFRKMAHAFALAKNVRNFDFFGKQKEHL--L 188
Query 711 AGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWL 750
+ ++ + L + +DE+ E L++ L L
Sbjct 189 TNSAKSLPILAHRALLEANRSKATKDEMREELAKFLKLSL 228
>sp|Q8R4D5|TRPM8_MOUSE Transient receptor potential cation channel
subfamily M member 8 OS=Mus musculus OX=10090 GN=Trpm8
PE=1 SV=3
Length=1104
Score = 33.9 bits (76), Expect = 7.9, Method: Composition-based stats.
Identities = 25/158 (16%), Positives = 56/158 (35%), Gaps = 8/158 (5%)
Query 410 EHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFIL 469
P +++ F F + + N++ + + +++L + IL
Sbjct 713 RKKPIDKHKKLLWYYVAF-FTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELIL 771
Query 470 GILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPG 529
L VF+ + E + + + G Y + NV D L + + L
Sbjct 772 YAL--VFV-LFCDE-VRQWYMNG-VNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLY 826
Query 530 WRPEMVGLLSLWDMTRMLNMLIVFRFL--RIIPSMKLM 565
+ L + R++++ V R L +II +++
Sbjct 827 SGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRML 864
>sp|Q18600|ERP1B_CAEEL Putative endoplasmic reticulum metallopeptidase
1-B OS=Caenorhabditis elegans OX=6239 GN=C44B7.11 PE=1
SV=4
Length=895
Score = 33.5 bits (75), Expect = 8.3, Method: Composition-based stats.
Identities = 15/83 (18%), Positives = 34/83 (41%), Gaps = 15/83 (18%)
Query 433 YFDYLGNLIA--------LANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEM 484
+FD+LG + L N+++IC + L + ++ L + + V + + +
Sbjct 376 FFDFLGLFVIIYPLSIAHLVNMLTICTVIALMSHRFYSKTFITFLALRDYVLTIL-TIAL 434
Query 485 LLK------VFALGLRGYLSYPS 501
+LK +F G + +
Sbjct 435 VLKAMTFMSLFTYGALRWYTRHW 457
>sp|P0C6Y5|R1AB_CVPPU Replicase polyprotein 1ab OS=Porcine transmissible
gastroenteritis coronavirus (strain Purdue) OX=11151
GN=rep PE=1 SV=1
Length=6684
Score = 33.5 bits (75), Expect = 9.7, Method: Composition-based stats.
Identities = 32/213 (15%), Positives = 68/213 (32%), Gaps = 17/213 (8%)
Query 475 VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEM 534
F M + +FA L ++ P + + ++ T + + G + +M
Sbjct 3187 FFYPIMTA-MTI-LFAFWLEFFMYTPFTW---INPTFVSIVLAVTTLISTVFVSGIKHKM 3241
Query 535 VGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFA 594
+ +S + +L F L ++V +T + + V + VF
Sbjct 3242 LFFMSFVLPSVILVTAHNL-FWDFSYYESLQSIVENTNTMFLPVDMQGVMLTVFCFIVFV 3300
Query 595 IIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANN---FDDFAAALVTLWNLMV 651
+ F + + E W N F F ++T+ +
Sbjct 3301 TYSVRFFTCKQSWFSLAVTTILVIFNMVKIFGTSDEPWTENQIAF-CFVN-MLTMIVSLT 3358
Query 652 VNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVI 684
+W V + +YR Y V+ + S+ +
Sbjct 3359 TKDWMVVIASYRIA------YYIVVCVMPSAFV 3385
Lambda K H a alpha
0.318 0.129 0.345 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0396 0.140 1.90 42.6 43.6
Effective search space used: 84595262452
Database: uniprot_sprot.fasta
Posted date: Oct 6, 2024 4:14 PM
Number of letters in database: 207,235,166
Number of sequences in database: 572,214
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40