PSIBLAST 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Stephen F.
Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005)
"Protein database searches using compositionally adjusted
substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: uniprot_sprot.fasta
573,661 sequences; 207,922,125 total letters
Results from round 1
Query= sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6
PE=1 SV=2
Length=910
Score E
Sequences producing significant alignments: (Bits) Value
sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 ... 1899 0.0
sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6... 1668 0.0
sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 ... 887 0.0
sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5... 851 0.0
sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4... 711 0.0
sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE... 711 0.0
sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 ... 707 0.0
sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 ... 668 0.0
sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3... 665 0.0
sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1... 603 0.0
sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 ... 594 0.0
sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2... 556 0.0
sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 ... 555 0.0
sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7... 533 2e-175
sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=A... 530 3e-174
sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 ... 525 2e-171
sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 ... 429 2e-136
sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9... 384 1e-119
sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO... 171 3e-43
sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=An... 169 2e-42
sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano1... 164 6e-41
sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 ... 119 7e-26
sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8... 118 8e-26
sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryz... 115 4e-25
sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabido... 102 7e-21
sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosa... 100 2e-20
sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Sacc... 41.2 0.052
sp|Q2S8D3|F16PA_HAHCH Fructose-1,6-bisphosphatase class 1 OS=Hahe... 35.4 2.2
sp|Q9VNS0|MAEL_DROME Protein maelstrom OS=Drosophila melanogaster... 34.7 4.5
sp|Q12202|OSW2_YEAST Outer spore wall protein 2 OS=Saccharomyces ... 34.3 5.9
sp|Q1KXV4|NU3C_HELAN NAD(P)H-quinone oxidoreductase subunit 3, ch... 32.3 7.4
sp|B2LMJ8|NU3C_GUIAB NAD(P)H-quinone oxidoreductase subunit 3, ch... 32.3 7.4
sp|Q6R799|Y120_OSHVF Uncharacterized protein ORF120 OS=Ostreid he... 30.8 8.6
>sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6
PE=1 SV=2
Length=910
Score = 1899 bits (4919), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 910/910 (100%), Positives = 910/910 (100%), Gaps = 0/910 (0%)
Query 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL
Sbjct 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60
Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK
Sbjct 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180
LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE
Sbjct 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180
Query 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240
FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI
Sbjct 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240
Query 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA
Sbjct 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL
Sbjct 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420
NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP
Sbjct 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420
Query 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480
EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV
Sbjct 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480
Query 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540
FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP
Sbjct 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540
Query 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600
RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC
Sbjct 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600
Query 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660
LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK
Sbjct 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660
Query 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720
LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD
Sbjct 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720
Query 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780
IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL
Sbjct 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780
Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV
Sbjct 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900
MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA
Sbjct 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900
Query 901 VDNNLRPKSE 910
VDNNLRPKSE
Sbjct 901 VDNNLRPKSE 910
>sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6
PE=1 SV=1
Length=911
Score = 1668 bits (4319), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 821/912 (90%), Positives = 863/912 (95%), Gaps = 3/912 (0%)
Query 1 MKKMSRNVLLQMEEEEDDDDGD-IVLENLGQTIV-PDLGSLESQHDFRTPEFEEFNGKPD 58
M+ M+R VLL ME EEDDD+ IVLEN QTIV P GSLE+Q DFRTPEFEEFNGKPD
Sbjct 1 MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPD 60
Query 59 SLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLD 118
SLFF DGQRRIDF+LVYEDES+KE NKKGTNEKQ+RKRQAYESNLICHGLQLEATRSV D
Sbjct 61 SLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSD 120
Query 119 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178
DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK RS FG LNWFTKVL V+ES+IKPE
Sbjct 121 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRS-PFGNLNWFTKVLRVNESVIKPE 179
Query 179 QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNS 238
QEFFTAPFEK+RMNDFYI+DRD+FFNPATRSRIVYFILSRVKYQV+NNV+KFGINRLV+S
Sbjct 180 QEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSS 239
Query 239 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 298
GIYKAAFPLHDC+F +SED SCP+ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY
Sbjct 240 GIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 299
Query 299 FAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFW 358
FAWLGYYTQMLLLAAVVGVACFLYGYL+QDNCTWSKEVC PDIGG+I+MCPQCDRLCPFW
Sbjct 300 FAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFW 359
Query 359 KLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 418
+LNITCESSKKLCIFDSFGTL+FAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA
Sbjct 360 RLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 419
Query 419 RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478
RPEYEA+C HVVINEITQEEERIPFT GKCIR+TLCASAVFFWILLIIASVIGIIVYRL
Sbjct 420 RPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRL 479
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
SVFIVFS LPKN NGTDPIQKYLTPQ ATSITASIISFIIIMILNTIYEKVAIMITNFE
Sbjct 480 SVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFE 539
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVY LGKYR+EECDPG
Sbjct 540 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPG 599
Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPM 658
GCLLELTTQLTIIMGGKAIWNNIQEVLLPW+MNLIGR+ RVSGSEKITPRWEQDYHLQPM
Sbjct 600 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPM 659
Query 659 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718
GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR+VPEKA
Sbjct 660 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKA 719
Query 719 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINN 778
QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS+PPYGDHT YTM+GYINN
Sbjct 720 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINN 779
Query 779 TLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFI 838
TLS+F + DFKN K NPY LGN+T CRYRDFR PPGHPQEYKHNIYYWHVIAAKLAFI
Sbjct 780 TLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFI 839
Query 839 IVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMI 898
IVMEH+IYSVKFFISYAIPDVSK TKSKI+REKYLTQKLLHE+HLKD+TKNMG+IAER+
Sbjct 840 IVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIG 899
Query 899 EAVDNNLRPKSE 910
VDN++RPK E
Sbjct 900 GTVDNSVRPKLE 911
>sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5
PE=1 SV=1
Length=913
Score = 887 bits (2293), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 435/855 (51%), Positives = 597/855 (70%), Gaps = 37/855 (4%)
Query 50 FEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQ 109
F++ DS+FF DG R+IDFVL Y D+ +K+ K +R+ +E+NL GL+
Sbjct 61 FQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELKA------ERRKEFETNLRKTGLE 114
Query 110 LEA--TRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKV 167
LE R D + FVK+HAPWEVL TYAE++ IK+P+K +D+ +++
Sbjct 115 LEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHT--PISYVLGP 172
Query 168 LSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNV 227
+ + S+ P E+FTA F ++R F I D+ FF ++R+RIVY+ILSR + + +
Sbjct 173 VRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGK 232
Query 228 SKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLI 287
+FGI RL+NS Y +A+PLHD ++ + SE P+ NERY L++ WA YK+QPLDLI
Sbjct 233 KRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLI 292
Query 288 RKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIM 347
+ YYGEKIGIYF +LG+YT+ML AAVVG+ACF+YG L+ ++ T S E+C P+IGG++IM
Sbjct 293 KNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIM 352
Query 348 CPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEW 407
CP CD++C +W+LN TC +SK +FD+ T+ FA+FMG+WVTLFLEFWK+RQA LEYEW
Sbjct 353 CPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEW 412
Query 408 DTVELQQEEQA---RPEYEARCTHVVINEITQEEE-------RIPFTAWGKCIRITLCAS 457
D V+ ++E+Q RPE+EA C H +N +T+E E RIP+ L +
Sbjct 413 DLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPW--------YFLSGA 464
Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517
V W+ L++ S++ +IVYRLSVF F++ + + + ++ +LTPQ TS+T S ++F
Sbjct 465 TVTLWMSLVVTSMVAVIVYRLSVFATFASFMESDAS-LKQVKSFLTPQITTSLTGSCLNF 523
Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577
I+I+ILN YEK++ IT E+PRT +YE+SLT+KMFLFQFVN+YSSCFY+AFFKGKFV
Sbjct 524 IVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFV 583
Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637
GYPG Y ++R+EECDPGGCL+ELTTQLTIIM GK I+ NI+E + P +N R
Sbjct 584 GYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRK 643
Query 638 RVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNIL 697
+ SEK+ RWEQD+ L+ G LGLFYEYLE + QFGFVTLFVASFPLAPLLAL+NNI+
Sbjct 644 ARTNSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIV 703
Query 698 EIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYW 757
EIRVDAWKLTTQ+RR V KA IG WQ I+ G+A+L+V TNA I+AFTSD+IPRLVYY+
Sbjct 704 EIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYY 763
Query 758 SFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGH 817
++S + + M GY+NN+LS+F +ADF N + + D TCRYRD+RYPP
Sbjct 764 AYST-----NATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDF---ITCRYRDYRYPPDD 815
Query 818 PQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKL 877
+Y HN+ +WHV+AAK+ FIIVMEHV++ VKF +++ IPDV K +I+REK +T K+
Sbjct 816 ENKYFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKI 875
Query 878 LHENHLKDMTKNMGV 892
LH+ L + +N+G+
Sbjct 876 LHDFELNKLKENLGI 890
>sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5
PE=2 SV=1
Length=904
Score = 851 bits (2198), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 439/905 (49%), Positives = 600/905 (66%), Gaps = 53/905 (6%)
Query 35 DLGSLESQ----HDFRTPEFEEFN-------------GKPDSLFFNDGQRRIDFVLVYED 77
+LGS E+ D ++P + FN DS+FF DG R+IDFVL Y +
Sbjct 21 NLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYVE 80
Query 78 ESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV--LDDKLVFVKVHAPWEVLCT 135
+ +K+ E + +R+ +E NL GL LE + D K FVK+HAPWEVL T
Sbjct 81 DLKKD------GELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLVT 134
Query 136 YAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFY 195
YAE++ IK+P+K +D+ + L++ + + S+ P E+FTA F ++R F
Sbjct 135 YAEVLGIKMPIKLSDIPR--PKYPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELFL 192
Query 196 IVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQ 255
I D FF +TR+RIVY+ILSR + V K GI RL+NS Y +A+PLHD ++ +
Sbjct 193 IEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKP 252
Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315
S+ + PNERY L + WA YK+QP LIR Y+GEKIGIYF +LGYYT+MLL AA+V
Sbjct 253 SKT-TRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALV 311
Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375
G+ACF+YG L+ +N S E+C PDIGG++IMCP CD +C +W+LN TC SK +FD+
Sbjct 312 GLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDN 371
Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA---RPEYEARCTHVVIN 432
T+ FA+FMG+WVTLFLEFWK+RQA LEYEWD V+ ++E+Q RPE+EA C H +N
Sbjct 372 ESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKMN 431
Query 433 EITQE-EERIPFTAWGKCIRIT---LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488
+T+E E +P C RI + + V F + L+++S++ I++YRLSVF F++ +
Sbjct 432 PVTKEMEPHMPL-----CHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFM 486
Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548
++ + TPQ AT+++ S ++ I+I+ILN YEK++ IT E+PRT +YE+
Sbjct 487 ESEAT-LQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYES 545
Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608
SLT+KMFLFQFVNYYSSCFY+AFFKGKFVGYPG Y +R+EEC P GCL+ELTTQL
Sbjct 546 SLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQL 605
Query 609 TIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYL 668
TIIM GK I+ NI E P I N R + SEK+ RWEQD+ LQ G GLFYEYL
Sbjct 606 TIIMIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYL 665
Query 669 EMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIM 728
E +IQFGF TLFVASFPLAPL AL+NNI+ IRVDAWKLTTQ+RR V KA IG WQ I+
Sbjct 666 ETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDIL 725
Query 729 QGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADF 788
G+AI++V TNA I++FTSD+IPRLVY++++S +++ + GY+NN+LS+F +ADF
Sbjct 726 FGMAIVSVATNAFIVSFTSDIIPRLVYFYAYST-----NSTEPLSGYVNNSLSVFLIADF 780
Query 789 KNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSV 848
N + D TCRYRD+RYPP H +Y HN+ +WHV+AAK+ FIIVMEHV++
Sbjct 781 PNHTVPMEKKDF---VTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLF 837
Query 849 KFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM----GVIAERMIEAVDNN 904
KF +++ IPDV K KI+REK +T K++H+ L + +N+ G I + ++ DN+
Sbjct 838 KFLLAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNS 897
Query 905 LRPKS 909
L+ K+
Sbjct 898 LKAKT 902
>sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4
PE=1 SV=2
Length=955
Score = 711 bits (1835), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 408/925 (44%), Positives = 588/925 (64%), Gaps = 74/925 (8%)
Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54
+++M+++V + +E E DDD + NL T D LE+ + E N
Sbjct 51 IQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SEDTSRLEAGGE----TVRERN 105
Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114
K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E
Sbjct 106 -KSNGLYFRDGKCRIDYILVYRKSN-----------PQTEKREVFERNIRAEGLQMEKES 153
Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164
S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F
Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213
Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221
K + +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY
Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKY 273
Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279
+ N K G+NRL+ +G Y+AAFPLH+ +R ++ + N R+LLY WA Y
Sbjct 274 EEGKN--KIGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWGVWY 331
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+C SKEVC
Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQ- 390
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR
Sbjct 391 --ATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448
Query 400 QAELEYEWDTVE-LQQEEQARPEYEARCTHV-VINEITQEEERIPFTAW-GKCIRITLCA 456
+A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E P+ A+ KC R+ + A
Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPE--PYQAFTDKCSRLIVSA 506
Query 457 SAVFFWILLIIASVIGIIVYRL---SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513
S +FF I ++IA+V GI++YR+ S F F L +N Q AT+ TA
Sbjct 507 SGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRN-----------NSQVATTGTAV 555
Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573
I+F IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF
Sbjct 556 CINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFL 615
Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633
G+F G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N
Sbjct 616 GRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWW 675
Query 634 GR--FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPL 689
R + G+E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPL
Sbjct 676 TRRKVRQEHGTERKINFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPL 735
Query 690 LALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDM 749
LAL+NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD
Sbjct 736 LALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDF 795
Query 750 IPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT--- 805
IPRLVY + + G+ M GY+N +LS+F+++DF+N+S+ P SD +
Sbjct 796 IPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPL 853
Query 806 --CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRT 863
CRYRD+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K
Sbjct 854 KYCRYRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDL 913
Query 864 KSKIQREKYLTQKLLHENHLKDMTK 888
+ +++REKYL Q++++E L+ + K
Sbjct 914 RDRMRREKYLIQEMMYEAELERLQK 938
>sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4
PE=2 SV=1
Length=920
Score = 711 bits (1835), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 407/902 (45%), Positives = 578/902 (64%), Gaps = 68/902 (8%)
Query 18 DDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYED 77
DDD + NL T D LE+ + PE + NG L+F DG+ RID++LVY
Sbjct 39 DDDSLLHPGNLTST-SDDASRLEAGGE-TVPEKNKLNG----LYFRDGKCRIDYILVYRK 92
Query 78 ESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYA 137
+ Q KR+ +E N+ GLQ+E S+++ ++FVK+HAPWEVL YA
Sbjct 93 SN-----------PQMEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYA 141
Query 138 EIMHIKLPLK------PNDLKNRSSAFGTLNWF-----TKVLSVDESIIK--PEQEFFTA 184
E M++++P + P K S ++ F K + +D+ + E + +TA
Sbjct 142 EQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTA 201
Query 185 PFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAA 244
PF + R++ F I ++D FFN ATRSRIV+ IL R+KY+ N K G+NRL+ +G Y+AA
Sbjct 202 PFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYEEGKN--KIGLNRLLTNGSYEAA 259
Query 245 FPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWL 302
FPLH+ +R ++ N R+LLY WA YK QPLDL+R+Y+GEKIG+YFAWL
Sbjct 260 FPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWL 319
Query 303 GYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNI 362
G+YT ML AA +G+ FLYG + D+C SKEVC IIMCP CD+ CPF +L+
Sbjct 320 GWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVCQ---ATDIIMCPVCDKYCPFMRLSD 376
Query 363 TCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE-LQQEEQARPE 421
+C +K +FD+ T+ FAVFM VW T+FLEFWKRR+A + Y+WD ++ ++EE+ RP+
Sbjct 377 SCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQ 436
Query 422 YEARCTHV-VINEITQEEERIPFTAWG-KCIRITLCASAVFFWILLIIASVIGIIVYRL- 478
+EA+ + +N I+ + E P+ A+ KC R+ + AS +FF I ++IA+V GI++YR+
Sbjct 437 FEAKYSKKERMNPISGKPE--PYQAFADKCSRLIVSASGIFFMICVVIAAVFGIVIYRVV 494
Query 479 --SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITN 536
S F F L +N Q AT+ TA I+F IIM+LN +YEKVA+++TN
Sbjct 495 TVSTFAAFKWALIRN-----------NSQVATTGTAVCINFCIIMLLNVLYEKVALLLTN 543
Query 537 FELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECD 596
E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F G+PG + + ++R EEC
Sbjct 544 LEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECH 603
Query 597 PGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGR--FHRVSGSE-KIT-PRWEQD 652
P GCL++L Q+ IIM K WNN E+ P I N R + G E KI+ P+WE+D
Sbjct 604 PSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKD 663
Query 653 YHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712
Y+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+NNI+EIR+DA+K TQ+RR
Sbjct 664 YNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRR 723
Query 713 LVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS-VPPYGDHTSYT 771
+ +A+DIG W I++GI IL+V+TNA +IA TSD IPRLVY + + G+
Sbjct 724 PLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKC 783
Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT-----CRYRDFRYPPGHPQEYKHNIY 826
M GY+N +LS+F+++DF+N+S+ P SD + CRYRD+R PP Y + +
Sbjct 784 MVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQ 841
Query 827 YWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDM 886
+WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++REKYL Q++++E L+ +
Sbjct 842 FWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERL 901
Query 887 TK 888
K
Sbjct 902 QK 903
>sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4
PE=1 SV=1
Length=955
Score = 707 bits (1824), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 409/925 (44%), Positives = 588/925 (64%), Gaps = 74/925 (8%)
Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54
+++M+++V + +E E DDD + NL T D LE+ + PE + N
Sbjct 51 IQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTST-SDDASRLEAGGE-TVPERNKSN 108
Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114
G L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E
Sbjct 109 G----LYFRDGKCRIDYILVYRKSN-----------PQTEKREVFERNIRAEGLQMEKES 153
Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164
S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F
Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213
Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221
K + +D+ + E + +TAPF + R++ F I +++ FFN ATRSRIV+ IL R+KY
Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKY 273
Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279
+ N K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA Y
Sbjct 274 EEGKN--KIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWY 331
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+ SKEVC
Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQ- 390
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR
Sbjct 391 --ATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448
Query 400 QAELEYEWDTVE-LQQEEQARPEYEARCTHV-VINEITQEEERIPFTAW-GKCIRITLCA 456
+A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E P+ A+ KC R+ + A
Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPE--PYQAFTDKCSRLIVSA 506
Query 457 SAVFFWILLIIASVIGIIVYRL---SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513
S +FF I ++IA+V GI++YR+ S F F L +N Q AT+ TA
Sbjct 507 SGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRN-----------NSQVATTGTAV 555
Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573
I+F IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF
Sbjct 556 CINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFL 615
Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633
G+F G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N
Sbjct 616 GRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWW 675
Query 634 GR--FHRVSGSE-KIT-PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPL 689
R + G E KI+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPL
Sbjct 676 TRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPL 735
Query 690 LALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDM 749
LAL+NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD
Sbjct 736 LALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDF 795
Query 750 IPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT--- 805
IPRLVY + + G+ M GY+N +LS+F+++DF+N+S+ P SD +
Sbjct 796 IPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPL 853
Query 806 --CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRT 863
CRYRD+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K
Sbjct 854 KYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDL 913
Query 864 KSKIQREKYLTQKLLHENHLKDMTK 888
+ +++REKYL Q++++E L+ + K
Sbjct 914 RDRMRREKYLIQEMMYEAELERLQK 938
>sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3
PE=1 SV=2
Length=981
Score = 668 bits (1724), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 376/852 (44%), Positives = 537/852 (63%), Gaps = 64/852 (8%)
Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
F DG++RID++LVY ++TN Q KR +E NL GL LE ++
Sbjct 156 LFKDGKKRIDYILVY-----RKTNI------QYDKRNTFEKNLRAEGLMLEKEPAIASPD 204
Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPND--LKNRSSAFGTL--------NWFTKVLSV 170
++F+K+H PW+ LC YAE ++I++P + RS + G + NW + V
Sbjct 205 IMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMV 264
Query 171 DESIIKP---EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNV 227
+ P E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+ N +
Sbjct 265 LDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE--NGI 322
Query 228 SKFGINRLVNSGIYKAAFPLHDCKFRR----QSEDPSCPNERYLLYREWAHPRSIYKKQP 283
SK GI +L+N+G Y AAFP H+ ++ ++ P N R+LLY WA YK QP
Sbjct 323 SKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQ--NNRHLLYERWARWGMWYKHQP 380
Query 284 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGG 343
LDLIR Y+GEKIG+YFAWLG+YT ML+ AA+VG+ F YG +N S+E+C
Sbjct 381 LDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICK---AT 437
Query 344 KIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAEL 403
++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++ L
Sbjct 438 EVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSIL 497
Query 404 EYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAVFF 461
Y WD +E ++EE+ RP++EA+ + ++N IT + E ++ K R+ + S +FF
Sbjct 498 TYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSS-DKVTRLLVSVSGIFF 556
Query 462 WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIM 521
I L+I +V G++VYRL V F A N I++Y Q ATS A I+FIIIM
Sbjct 557 MISLVITAVFGVVVYRLVVMEQF-ASFKWNF-----IKQYW--QFATSAAAVCINFIIIM 608
Query 522 ILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPG 581
+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+PG
Sbjct 609 LLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPG 668
Query 582 DPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSG 641
++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R H++
Sbjct 669 KYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSR-HKIKR 727
Query 642 S--EKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEI 699
+ P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+EI
Sbjct 728 GIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEI 787
Query 700 RVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSF 759
R+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY + +
Sbjct 788 RLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKY 847
Query 760 SVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPG 816
P +H + ++GY+NN+LS F +++ +G CRYRD+R PP
Sbjct 848 G--PCANHVEPSENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPPW 895
Query 817 HPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQK 876
+ Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPDV K +I+REKYL Q+
Sbjct 896 SSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQE 955
Query 877 LLHENHLKDMTK 888
+++E L+ + +
Sbjct 956 MMYEAELEHLQQ 967
>sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3
PE=1 SV=1
Length=981
Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 375/855 (44%), Positives = 541/855 (63%), Gaps = 64/855 (7%)
Query 58 DSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVL 117
L F DG++RID++LVY ++TN Q KR +E NL GL LE ++
Sbjct 153 SGLLFKDGKKRIDYILVY-----RKTNI------QYDKRNTFEKNLRAEGLMLEKEPAIA 201
Query 118 DDKLVFVKVHAPWEVLCTYAEIMHIKLPLKP----NDLKNRSSAFGTLNWFTKV------ 167
+ ++F+K+H PW+ LC YAE ++I++P + D KN+S + N+F ++
Sbjct 202 NPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKS-RVQNYFKRIKKWMSQ 260
Query 168 --LSVDESIIKP--EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223
+ +D+S E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+
Sbjct 261 NPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319
Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR----QSEDPSCPNERYLLYREWAHPRSIY 279
N +SK GI +L+ +G Y AAFP H+ ++ ++ P N R+LLY WA Y
Sbjct 320 -NGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQ--NNRHLLYERWARWGMWY 376
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AAVVG+ F YG + + S+E+C
Sbjct 377 KHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICK- 435
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR
Sbjct 436 --ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRR 493
Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457
++ L Y WD +E ++EE+ RP++EA+ + VIN IT + E ++ K R+ + S
Sbjct 494 RSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSS-DKVTRLLVSVS 552
Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517
+FF I L+I +V ++VYRL V F A N ++++ Q ATS A I+F
Sbjct 553 GIFFMISLVITAVFAVVVYRLVVMEQF-ASFKWNF-----VKQHW--QFATSGAAVCINF 604
Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577
IIIM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FV
Sbjct 605 IIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFV 664
Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637
G+PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R
Sbjct 665 GHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHK 724
Query 638 RVSGSEKIT-PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNI 696
G + + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI
Sbjct 725 IKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNI 784
Query 697 LEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYY 756
+EIR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY
Sbjct 785 IEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYE 844
Query 757 WSFSVPPYGDHTSYT---MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRY 813
+ + P +H ++GY+NN+LS F +++ +G CRYRD+R
Sbjct 845 YKYG--PCANHVKQNENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRG 892
Query 814 PPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYL 873
PP + Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPD+ K + +I+REKYL
Sbjct 893 PPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYL 952
Query 874 TQKLLHENHLKDMTK 888
Q++++E L+ + +
Sbjct 953 VQEMMYEAELEHLQQ 967
>sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1
PE=1 SV=2
Length=960
Score = 603 bits (1554), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 355/946 (38%), Positives = 522/946 (55%), Gaps = 99/946 (10%)
Query 33 VPDLGSLESQHDFRTPEFEEFNGKPDS-----LFFNDGQRRIDFVLVYE----------- 76
+ DLG L S+ + PD+ L+F DG+R++D++LVY
Sbjct 25 IEDLGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLA 80
Query 77 ----------------------------DESRKETNKKGTNEKQRRKRQAYESNLICHGL 108
D E + +R +R+ YE NL+ GL
Sbjct 81 RRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRFRREEYEGNLLEAGL 140
Query 109 QLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVL 168
+LE + FVK+HAPW VLC AE + +K+P K + + S G L VL
Sbjct 141 ELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTK--KVYHISETRGLLKTINSVL 198
Query 169 SVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVK 220
I+P+ + + PF + + + F + DRD+FF+ TRS IVY IL R
Sbjct 199 QKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIVYEILKRT- 257
Query 221 YQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYK 280
GI L+ +G+Y AA+PLHD + + + N+R LLY EWA YK
Sbjct 258 -TCTKAKYSMGITSLLANGVYSAAYPLHDGDYEGDNVEF---NDRKLLYEEWASYGVFYK 313
Query 281 KQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPD 340
QP+DL+RKY+GEK+G+YFAWLG YTQML+ A++VGV FLYG D S E+C D
Sbjct 314 YQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMC--D 371
Query 341 IGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQ 400
I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM +W F+E WKR+Q
Sbjct 372 QRYNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQ 431
Query 401 AELEYEWDTVELQQEEQA-----RPEYEARCTHVVINEIT--QEEERIPFTAWGKCIRIT 453
L Y WD ++EE+A R EYEAR + + + +E +++ T +
Sbjct 432 MRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDRFPAYF 491
Query 454 LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513
++ F I + A V+G+I+YR+S + +N + ++ + + + TA
Sbjct 492 TNLVSIIFMIAVTFAIVLGVIIYRISTAAALA------MNSSPSVRSNI--RVTVTATAV 543
Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573
II+ ++I++L+ +Y +A +T E+P+T+ +E LT K FL +FVN Y+ FY+AFFK
Sbjct 544 IINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFK 603
Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNL 632
G+FVG PGD VY +R EEC PGGCL+EL QL+IIM GK I NN+ E+ +P +
Sbjct 604 GRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKF 663
Query 633 IG--RFHRVSGSE-----KITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFP 685
I + R S S+ K R+E D++L+P GL EY+EMIIQFGFVTLFVASFP
Sbjct 664 IRYLKLRRQSPSDREEYVKRKQRYEVDFNLEPFA--GLTPEYMEMIIQFGFVTLFVASFP 721
Query 686 LAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAF 745
LAPL AL+NNI+EIR+DA K T+ RR V +A+DIG W I++G+ LAV+ NA +I+F
Sbjct 722 LAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISF 781
Query 746 TSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT 805
TSD IPRLVY + +S + TM G++N+TLS F V+DF+N + N DLG
Sbjct 782 TSDFIPRLVYLYMYS-------QNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQ 834
Query 806 -CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTK 864
CRY+D+R PP +Y + +W V+AA+LAF+IV ++++ + F+ + IPD+ K
Sbjct 835 ICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDIS 894
Query 865 SKIQREKYLTQKL-LHENHLKDMTKNMGVIAERMIEAVDNNLRPKS 909
+I +EK L +L + E K + + E+ + NN P +
Sbjct 895 QQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTT 940
>sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1
PE=1 SV=1
Length=986
Score = 594 bits (1532), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 350/942 (37%), Positives = 519/942 (55%), Gaps = 128/942 (14%)
Query 33 VPDLGSLESQHDFRTPEFEEFNGKPDS-----LFFNDGQRRIDFVLVYEDESRKETNK-- 85
+ D+G L S+ + PD+ L+F DG+R++D++LVY R N+
Sbjct 25 IEDIGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGRRKVDYILVYH-HKRPSGNRTL 79
Query 86 ------------------------KGTN--------------EKQRRKRQAYESNLICHG 107
KG + + +R +R+ YE NL+ G
Sbjct 80 VRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAG 139
Query 108 LQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKV 167
L+LE + FVK+HAPW VLC AE + +K+P K + + + G L V
Sbjct 140 LELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTK--KMYHINETRGLLKKINSV 197
Query 168 LSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRV 219
L I+P+ + + PF + + + F + D+D+FF+ TRS IVY IL R
Sbjct 198 LQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRT 257
Query 220 KYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279
GI L+ +G+Y AA+PLHD + ++ + N+R LLY EWA Y
Sbjct 258 --TCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEF---NDRKLLYEEWARYGVFY 312
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QP+DL+RKY+GEKIG+YFAWLG YTQML+ A++VG+ FLYG D S E+C
Sbjct 313 KYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMC-- 370
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM +W F+E WKR+
Sbjct 371 DQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRK 430
Query 400 QAELEYEWDTVELQQEEQA-----RPEYEARCTHVVINEITQEEER---IP---FTAWGK 448
Q L Y WD ++EE+A R EYEAR + + ++ +E+ IP W +
Sbjct 431 QMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQ 490
Query 449 CIRITLCA----------------------SAVFFWILLIIASVIGIIVYRLSVFIVFSA 486
++ + ++ F I + A V+G+I+YR+S+ +
Sbjct 491 RVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALA- 549
Query 487 KLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDY 546
+N + ++ + + + TA II+ ++I++L+ +Y +A +T E+P+T+ +
Sbjct 550 -----MNSSPSVRSNI--RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSF 602
Query 547 ENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTT 606
E L K FL +FVN Y+ FY+AFFKG+FVG PGD VY +R EEC PGGCL+EL
Sbjct 603 EERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCI 662
Query 607 QLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSE--------KITPRWEQDYHLQP 657
QL+IIM GK I NN+ E+ +P + LI R+ ++ K R+E DY+L+P
Sbjct 663 QLSIIMLGKQLIQNNLFEIGIPKMKKLI-RYLKLKQQSPPDHEECVKRKQRYEVDYNLEP 721
Query 658 MGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEK 717
GL EY+EMIIQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K T+ RR V +
Sbjct 722 FA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVR 779
Query 718 AQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYIN 777
A+DIG W I++GI LAV+ NA +I+FTSD IPRLVY + +S + TM G++N
Sbjct 780 AKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYS-------KNGTMHGFVN 832
Query 778 NTLSIFKVADFKNKSKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836
+TLS F V+DF+N + N DLG CRY+D+R PP +Y + +W V+AA+LA
Sbjct 833 HTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLA 892
Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLL 878
F+IV ++++ + F+ + IPD+ K +I +EK L +L
Sbjct 893 FVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELF 934
>sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2
PE=1 SV=2
Length=1002
Score = 556 bits (1434), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 330/894 (37%), Positives = 483/894 (54%), Gaps = 97/894 (11%)
Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97
+ F+D QR++D+VL Y E+ KE + G + +
Sbjct 90 MHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLD 149
Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146
A E NL+ GL+LE VFV++HAPW+VL AE + IK+P
Sbjct 150 ALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPT 209
Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVD 198
K + + F+ +L S ++P + + PF + +M + I +
Sbjct 210 K--KMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQE 267
Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258
+D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D
Sbjct 268 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPGDD 325
Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318
N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV
Sbjct 326 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 382
Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378
FLYG + SKE+C D MCP CD+ C +W L+ C +++ +FD+ T
Sbjct 383 VFLYGCATIEEDIPSKEMC--DHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPAT 440
Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433
+ F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E
Sbjct 441 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKE 500
Query 434 -----ITQEEERIPFTAWGKCIRIT---------LCASAVFFWILLIIASVIGIIVYRLS 479
+ + E P ++T + +++ F I L + V G+IVYR++
Sbjct 501 SGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT 560
Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539
S N + + TA II+ ++I+IL+ IY VA +T E+
Sbjct 561 TAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEV 610
Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599
P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PGG
Sbjct 611 PKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGG 670
Query 600 CLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSEKITP-------RWEQ 651
CL+EL QL+IIM GK I NNI E+ +P + L + + + P +W+
Sbjct 671 CLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDL 730
Query 652 DYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFR 711
D+ L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+ R
Sbjct 731 DHSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELR 788
Query 712 RLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT 771
R + +DIG W I+ GI +V+ NA +IA TSD IPRLVY +S+S H T
Sbjct 789 RPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYS------HNG-T 841
Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVI 831
+ G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW V+
Sbjct 842 LHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVL 901
Query 832 AAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884
+A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K
Sbjct 902 SARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 955
>sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2
PE=1 SV=2
Length=1003
Score = 555 bits (1429), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 329/895 (37%), Positives = 483/895 (54%), Gaps = 97/895 (11%)
Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97
+ F+D QR++D+VL Y E+ KE + G + +
Sbjct 90 MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 149
Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146
A E NL+ GL+LE +FV++HAPW+VL AE + IK+P
Sbjct 150 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 209
Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 198
K ++ + F+ L S ++P + + + PF + +M + I +
Sbjct 210 K-KEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 268
Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258
+D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D
Sbjct 269 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 326
Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318
N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV
Sbjct 327 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 383
Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378
FLYG + S+E+C D MCP CD+ C +W L+ C +++ +FD+ T
Sbjct 384 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 441
Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433
+ F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E
Sbjct 442 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 501
Query 434 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478
Q E++ T + + +++ F I L + V G+IVYR+
Sbjct 502 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 561
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
+ S N + + TA II+ ++I+IL+ IY VA +T E
Sbjct 562 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 611
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
+P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PG
Sbjct 612 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 671
Query 599 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 650
GCL+EL QL+IIM GK I NNI E+ +P + L + S K +W+
Sbjct 672 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 731
Query 651 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 710
DY L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+
Sbjct 732 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 789
Query 711 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 770
RR + +DIG W I+ GI +V++NA +IA TSD IPRLVY +S+S H
Sbjct 790 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 842
Query 771 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 830
T+ G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW +
Sbjct 843 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 902
Query 831 IAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884
++A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K
Sbjct 903 LSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 957
>sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7
PE=1 SV=2
Length=859
Score = 533 bits (1374), Expect = 2e-175, Method: Compositional matrix adjust.
Identities = 312/825 (38%), Positives = 475/825 (58%), Gaps = 57/825 (7%)
Query 69 IDFVLVYEDESRKETN-KKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125
IDFVLV+E++ R + N K + R+ + NL GL+++ V D+ ++
Sbjct 55 IDFVLVWEEDLRNQENPTKDKTDTHEVWRETFLENLCLAGLKID-QHDVQDEAAAVHYIL 113
Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183
+ APW VLC YAE + +KLPL+ PN N S+ L W + E + E+++
Sbjct 114 LRAPWAVLCYYAEDLRLKLPLQELPNQASNWSATL--LEWLGIPNILLEHVPDTPPEYYS 171
Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242
F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++
Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKGLFGIDQLLAEGVFS 230
Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA
Sbjct 231 AAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFA 290
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L
Sbjct 291 WLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSS--DSFDMCPLCSD-CSFWLL 347
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419
+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R
Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478
P++ A +N IT E+E P+ +R L S V ++ + I ++ +I+YR
Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSVILYRA 465
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
+ I+ ++ +D S+T S+++ + I+IL+ +Y +A ++T +E
Sbjct 466 VMAII--------VSRSDNAFLSAWASRIASLTGSVVNLVFILILSKVYVLLAQVLTRWE 517
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
+ RTQT++E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ + L RNEEC G
Sbjct 518 MHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGN-YHTLFGIRNEECPAG 576
Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHR--VSGSEKITPRWEQDYHLQ 656
GCL EL +L +IM GK I NN+QEVL+P + +F R +G+ WE DY L
Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKFSRGKKAGTGTHPAPWEADYELL 636
Query 657 PMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPE 716
P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V E
Sbjct 637 PCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAE 694
Query 717 KAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYI 776
+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G++
Sbjct 695 RAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYSWTHAP---------DLHGFL 745
Query 777 NNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836
N TL ++ P ++ TCRYR FR GH ++ YW ++A +LA
Sbjct 746 NFTL-----------ARAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRLA 789
Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHEN 881
F+IV EHV++S+ + +PD+ + + K++RE YL ++ L EN
Sbjct 790 FVIVFEHVVFSIGRVLDLLVPDIPESVEIKVKREYYLAKQALAEN 834
>sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116
GN=Ano7 PE=2 SV=1
Length=860
Score = 530 bits (1366), Expect = 3e-174, Method: Compositional matrix adjust.
Identities = 319/844 (38%), Positives = 484/844 (57%), Gaps = 66/844 (8%)
Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125
IDFVLV+E++ R +E + + R+ + NL GL+++ R V D+ ++
Sbjct 55 IDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKID-QRDVQDEAAAVHYIL 113
Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183
+ APW VLC YAE + +KLPL+ PN N S+ L W + E++ E+++
Sbjct 114 LSAPWAVLCYYAEDLRLKLPLQELPNQASNWSATL--LEWLGIPNILLENVPDTPPEYYS 171
Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242
F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++
Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-QKKGLFGIDQLLAEGVFS 230
Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA
Sbjct 231 AAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFA 290
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L
Sbjct 291 WLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSS--DTFDMCPLCSD-CSFWLL 347
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419
+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R
Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478
P++ A +N IT E+E P+ +R L S V ++ + I ++ II+YR
Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSIILYRA 465
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTA--TSITASIISFIIIMILNTIYEKVAIMITN 536
+ I+ S K+ N +L+ + S+T S+++ + I+IL+ +Y +A ++T
Sbjct 466 VMAIIVS----KSNNA------FLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTR 515
Query 537 FELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECD 596
+E+ RTQT +E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ + L RNEEC
Sbjct 516 WEMHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGN-YHTLFGVRNEECP 574
Query 597 PGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWI----MNLIGRFHRVSGSEKITPRWEQD 652
GGCL EL +L +IM GK I NN+QEVL+P + L R + P WE D
Sbjct 575 AGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMGANPAP-WEAD 633
Query 653 YHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712
Y L P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR
Sbjct 634 YELLPCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRR 691
Query 713 LVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTM 772
V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + +
Sbjct 692 PVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWT---------RAPDL 742
Query 773 EGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIA 832
G++N TL ++ P ++ TCRYR FR GH ++ YW ++A
Sbjct 743 RGFLNFTL-----------ARAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLA 786
Query 833 AKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGV 892
+LAF+IV EHV++S F+ +PD+ + + K++RE YL ++ L +N + + GV
Sbjct 787 IRLAFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADN--EALLGATGV 844
Query 893 IAER 896
E+
Sbjct 845 KGEQ 848
>sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7
PE=1 SV=2
Length=933
Score = 525 bits (1352), Expect = 2e-171, Method: Compositional matrix adjust.
Identities = 318/839 (38%), Positives = 477/839 (57%), Gaps = 69/839 (8%)
Query 67 RRIDFVLVYEDE----SRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV 122
R DFVLV+E++ ++++ + + R R+ + NL GL ++ + V D
Sbjct 108 RIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVD-QQDVQDGNTT 166
Query 123 --FVKVHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178
+ + A W VLC YAE + +KLPL+ PN N S+ G L W + E +
Sbjct 167 VHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSA--GLLAWLGIPNVLLEVVPDVP 224
Query 179 QEFFTAPFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVN 237
E+++ F N++ F D +D FF R +I++ IL++ Y + GI++L+
Sbjct 225 PEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYG-HEKKNLLGIHQLLA 283
Query 238 SGIYKAAFPLHDCKFRRQSEDPSCP--NERYLLYREWAHPRSIYKKQPLDLIRKYYGEKI 295
G+ AAFPLHD F+ E P P N+R +L++ WA K QPLD +R+Y+GEK+
Sbjct 284 EGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKV 343
Query 296 GIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGK--IIMCPQCDR 353
+YFAWLG+YT LL AAVVG FL G + ++E+C G K MCP C
Sbjct 344 ALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELC----GSKDSFEMCPLCLD 399
Query 354 LCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ 413
CPFW L+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + +
Sbjct 400 -CPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYE 458
Query 414 Q-EEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIG 472
EE+ RP++ A N IT E+E F + R+ + + + +++ ++
Sbjct 459 DTEERPRPQFAASAPMTAPNPITGEDEPY-FPERSRARRMLAGSVVIVVMVAVVVMCLVS 517
Query 473 IIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAI 532
II+YR + IV S +G + + + S+T S+++ + I+IL+ IY +A
Sbjct 518 IILYRAIMAIVVSR------SGNTLLAAWAS--RIASLTGSVVNLVFILILSKIYVSLAH 569
Query 533 MITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRN 592
++T +E+ RTQT +E++ T+K+F+FQFVN+YSS YIAFFKG+FVGYPG+ + L RN
Sbjct 570 VLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGN-YHTLFGVRN 628
Query 593 EECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR---- 648
EEC GGCL+EL +L +IM GK + NN+QEVL+P + +F S K
Sbjct 629 EECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGAS 688
Query 649 ---WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWK 705
WE DY L P GLF EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K
Sbjct 689 QGPWEDDYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARK 746
Query 706 LTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYG 765
++RR V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR Y W+
Sbjct 747 FVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWT------- 799
Query 766 DHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHT-TCRYRDFRYPPGHPQEYKHN 824
++ + G++N TL+ P S H TCRYR FR GH ++
Sbjct 800 --RAHDLRGFLNFTLA------------RAPSSFAAAHNRTCRYRAFRDDDGH-----YS 840
Query 825 IYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHL 883
YW+++A +LAF+IV EHV++SV + +PD+ + + K++RE YL ++ L EN +
Sbjct 841 QTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEV 899
>sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9
PE=1 SV=3
Length=782
Score = 429 bits (1103), Expect = 2e-136, Method: Compositional matrix adjust.
Identities = 252/692 (36%), Positives = 395/692 (57%), Gaps = 77/692 (11%)
Query 206 ATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263
+ R RIV F+ V+NN + G L+ G+++A FPLH + R
Sbjct 117 SLRIRIVNFV-------VMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR---------- 159
Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323
L + WA R ++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G
Sbjct 160 ----LKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSG 215
Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383
+ + SKE+C I+MCP D + +L+ TC +K +FD+ GT+VFA+
Sbjct 216 FSLFEASQISKEICE---AHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAI 272
Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTV--ELQQEEQAR-----PEYEARCTHVVINEITQ 436
FM +W T+FLE WKR++A + WD + +QEE A P+Y+ R
Sbjct 273 FMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLR----------- 321
Query 437 EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTD 496
P+ +R T+ I L+I ++VYR+ +FS+ +
Sbjct 322 -----PYQH--SYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVP 368
Query 497 PIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFL 556
+++ +T TA +T +++ ++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F
Sbjct 369 FLEEQVT--TAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFT 426
Query 557 FQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA 616
QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+ IIMG K
Sbjct 427 LQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQ 486
Query 617 IWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEM 670
+N E L+PW+ + R R S S + PR W ++Y L P+ LF E++EM
Sbjct 487 TLSNCVEYLVPWVTHKC-RSLRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEM 544
Query 671 IIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQG 730
+IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG W +++
Sbjct 545 MIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLET 604
Query 731 IAILAVVTNAMIIAFTSDMIPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFK 789
I +LAV+ N M+IAFTS+ IPR+VY + +S G+ T ++GY+N++LS+F DF+
Sbjct 605 IGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQ 664
Query 790 NKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVK 849
+ G S+ N T CRYRD+R PP +Y + +W ++A +LAF+I+ EHV +K
Sbjct 665 DPD-GIEGSE--NVTLCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIK 717
Query 850 FFISYAIPDVSKRTKSKIQREKY--LTQKLLH 879
++ +PD+ + K+K+ KY L +K+ H
Sbjct 718 LIAAWFVPDIPQSVKNKVLEVKYQRLREKMWH 749
>sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9
PE=1 SV=1
Length=747
Score = 384 bits (986), Expect = 1e-119, Method: Compositional matrix adjust.
Identities = 238/692 (34%), Positives = 382/692 (55%), Gaps = 82/692 (12%)
Query 198 DRDAFFNPATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQ 255
D +F TR RIV F V+NN K G LV G+++ F LH +
Sbjct 105 DEQSFNIATTRIRIVSF--------VVNNKLKPGDTFEDLVKDGVFETMFLLHKGEQN-- 154
Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315
L WA R++++ QP+D IR+Y+GEK+ +YF WLG+YT ML+ AAVV
Sbjct 155 ------------LKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVV 202
Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375
G+ FL G+ D+ SKE+C + I MCP D + +L+ C +K +FD+
Sbjct 203 GLIVFLSGFALFDSSQISKEICSAN---DIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDN 259
Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQA-ELE----YEWDTVE--LQQEEQARPEYEARCTH 428
GT++FA+FM +W T+FLE WKR++A E++ YEWD E + E P Y+ +
Sbjct 260 EGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLK--- 316
Query 429 VVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488
+ R + + + ++L F I L+I ++VYR+ +FS+ +
Sbjct 317 ---------DHRHSYLSSTIILILSL------FMICLMIGMAHVLVVYRVLAGALFSSLV 361
Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548
+ + TA +T +++ +III+I+ + + VA+ + FE T ++ E
Sbjct 362 KQQV------------TTAVVVTGAVVHYIIIVIMTKVNKYVALKLCKFEESGTFSEQER 409
Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608
T+K F+ QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+
Sbjct 410 KFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQM 469
Query 609 TIIMGGKAIWNNIQEVLLP-----WIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL 663
IIMG K +N E L P W + + +S ++ W+++Y++ P+ L
Sbjct 470 AIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPEL-KEWQRNYYMNPINTFSL 528
Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723
F E++EM+IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG
Sbjct 529 FDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGT 588
Query 724 WQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT---MEGYINNTL 780
W +++ I +LAV+ N M+IAFTS+ IPR+VY + + P + ++T + Y+N++L
Sbjct 589 WLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYG--PCRTNRTFTDDCLTNYVNHSL 646
Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
S+F F + S+ N T CRYRD+R + +Y + +W ++A +L F+I+
Sbjct 647 SVFYTKHFNDHSRMEGQE---NVTVCRYRDYR----NEHDYNLSEQFWFILAIRLTFVIL 699
Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872
EH +K ++ +PDV ++ K+++ +EKY
Sbjct 700 FEHFALCIKLIAAWFVPDVPQKVKNEVLQEKY 731
>sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO10
PE=1 SV=2
Length=660
Score = 171 bits (433), Expect = 3e-43, Method: Compositional matrix adjust.
Identities = 145/525 (28%), Positives = 238/525 (45%), Gaps = 115/525 (22%)
Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204
Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDK---------------------- 242
Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
++FA F +W T+ LE WKR A + Y W T+
Sbjct 243 --------------------------YVIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276
Query 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
++++ E+ RP + IN IT +EE + + ++ + +RI L S F + L +
Sbjct 277 MKRKFEEPRPGFHGVLG---INSITGKEEPL-YPSYKRQLRIYLV-SLPFVCLCLYFSLY 331
Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
+ +I + + V+ + L +N +G++ L SII I+I I+N +Y
Sbjct 332 VMMIYFDMEVW---ALGLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380
Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425
Query 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 645
+ L L ++ I N I E LP+ + R H V K+
Sbjct 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472
Query 646 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701
+EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+
Sbjct 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532
Query 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
Score = 39.3 bits (90), Expect = 0.20, Method: Compositional matrix adjust.
Identities = 14/53 (26%), Positives = 35/53 (66%), Gaps = 0/53 (0%)
Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890
++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+
Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647
>sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=Ano10
PE=1 SV=1
Length=659
Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust.
Identities = 139/522 (27%), Positives = 238/522 (46%), Gaps = 109/522 (21%)
Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
+ RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+
Sbjct 158 MRRLLTSGIVTQVFPLHDTEALKKLEDT------------W-YTRFALKYQPIDSIRSYF 204
Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
GE I +YF +L Y+T L+ A++G+ +L+ + + D
Sbjct 205 GETIALYFGFLEYFTFALIPMAIIGLPYYLFVWEDYDK---------------------- 242
Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
++FA F +W T+ LE WKR A + Y W T+
Sbjct 243 --------------------------YVIFASFNLIWSTVILEVWKRGCANMTYRWGTLV 276
Query 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
++++ E+ RP + IN +T EE + ++++ + +RI L S F + L +
Sbjct 277 MKRQFEEPRPGFHGVLG---INSVTGREEPL-YSSYKRQLRIYL-VSLPFVCLCLYFSLY 331
Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
+ +I + + + + L ++ +G++ L SI+ ++I I+N +Y
Sbjct 332 VMMIYFDMEDW---ALSLHED-SGSEWTSLLL-------YVPSIVYAVVIEIMNRLYRYA 380
Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct 381 AEFLTSWENHRLESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKD--------------- 425
Query 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----IGRFHRVSGSEKI 645
+ L L ++ I N + E LLP+ + + R + SE
Sbjct 426 ----------MKLLRQSLATLLITSQILNQVVESLLPYWLQRKYCARVKRKVQALKSEVD 475
Query 646 TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAW 704
T +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+ DA
Sbjct 476 TTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDAL 535
Query 705 KLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
K+ F+R E + IG WQ + +++++VVTN +I +
Sbjct 536 KMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGMS 577
Score = 37.7 bits (86), Expect = 0.52, Method: Compositional matrix adjust.
Identities = 13/53 (25%), Positives = 34/53 (64%), Gaps = 0/53 (0%)
Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890
++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K + +N+
Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQQKLARLEFESLEALKQQQMKLVAENL 647
>sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano10
PE=2 SV=1
Length=646
Score = 164 bits (414), Expect = 6e-41, Method: Compositional matrix adjust.
Identities = 150/532 (28%), Positives = 233/532 (44%), Gaps = 129/532 (24%)
Query 232 INRLVNSGIYKAAFPLHDCK-FRRQSEDPSCPNERYLLYREWAHPRSIYKK-----QPLD 285
+ RL + G+ FPLH+ + +R S S YKK QPLD
Sbjct 158 VRRLQSKGVLVQYFPLHNKEDLKRLS-------------------FSWYKKIKLSFQPLD 198
Query 286 LIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKI 345
IR Y+GE +G+YF +L Y+T L+ A++G+ +L+ + + D
Sbjct 199 DIRSYFGEGLGLYFGFLEYFTFALIPMALIGIPYYLFDWEDYDK---------------- 242
Query 346 IMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEY 405
++FAVF VW T+FLE WKR A L Y
Sbjct 243 --------------------------------YVLFAVFNLVWSTVFLEVWKRCSATLAY 270
Query 406 EWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWIL 464
W T+ ++ E+ R + +N +T EE I + + + +RI L + V F +L
Sbjct 271 SWGTLGRKKAFEEPRAGFHGPLG---LNPVTGREEPI-YPSSKRHLRIYLVS--VPFVLL 324
Query 465 LIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSI---TASIISFIIIM 521
+ S ++VY F S + P ATS+ SII ++I
Sbjct 325 CLYLSFYVMMVYFDMEFWAISIY-------------HENPNFATSVLLFVPSIIYAVVIE 371
Query 522 ILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPG 581
I+N +Y A +T++E R ++ ++N L K+ +F FVN ++S FYIAF V
Sbjct 372 IMNLLYRYAAEFLTDWENHRLESSFQNHLVPKVLVFNFVNCFASLFYIAFVMQDMV---- 427
Query 582 DPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMN------LIGR 635
L L ++ I N + E LP+ + + R
Sbjct 428 ---------------------LLRQSLATLLITSQILNQVMEAFLPYWLQRRRNKRVYKR 466
Query 636 FHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVN 694
R+ G +++ P EQ M LG F +YLE + FG+V+LF PLA +L ++N
Sbjct 467 MRRLMGDKEL-PLLEQIQLETEMNTYLGTFDDYLEQFLLFGYVSLFSCVHPLAAVLVVLN 525
Query 695 NILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
NI E+ DA+K+ F+R E A +IG WQ + ++I+AVVTN +IA +
Sbjct 526 NITEVYSDAFKMCHVFKRPFSEPAANIGVWQLAFETMSIIAVVTNCALIALS 577
>sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8
PE=1 SV=3
Length=1232
Score = 119 bits (297), Expect = 7e-26, Method: Compositional matrix adjust.
Identities = 101/380 (27%), Positives = 169/380 (44%), Gaps = 88/380 (23%)
Query 202 FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIYKAAFPLHDCKFRR 254
FF R I+ F L ++ + ++NV I L GI + FP+H+ +
Sbjct 159 FFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILN 218
Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314
+ L + W ++ + QPLD I Y+G KI +YFAWLG+YT ++ AV
Sbjct 219 R------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAV 264
Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374
G LY + D + +++C
Sbjct 265 FG--SVLYTFTEADQTS----------------------------RDVSC---------- 284
Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQARPEYEARCTHVVIN 432
+VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ RP++ I+
Sbjct 285 ----VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRR---IS 337
Query 433 EITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNI 492
IT+ EE + W + + L + + L +A ++ + + L F + +L ++
Sbjct 338 PITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLVCVFLLMLGCFQL--QELVLSV 388
Query 493 NGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTM 552
G + ++L ++ +++ + Y+K+AI + + E R ++ YE L +
Sbjct 389 KGLPRLARFLP---------KVMLALLVSVSAEGYKKLAIWLNDMENYRLESAYEKHLII 439
Query 553 KMFLFQFVNYYSSCFYIAFF 572
K+ LFQFVN Y S FYI F+
Sbjct 440 KVVLFQFVNSYLSLFYIGFY 459
Score = 89.4 bits (220), Expect = 1e-16, Method: Compositional matrix adjust.
Identities = 39/81 (48%), Positives = 57/81 (70%), Gaps = 0/81 (0%)
Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723
F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR DA+KL T +R ++ + IG
Sbjct 745 FQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQ 804
Query 724 WQPIMQGIAILAVVTNAMIIA 744
WQ +M+ + +LA+V N +I
Sbjct 805 WQKVMEAMGVLAIVVNCYLIG 825
>sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8
PE=1 SV=3
Length=1060
Score = 118 bits (296), Expect = 8e-26, Method: Compositional matrix adjust.
Identities = 101/380 (27%), Positives = 170/380 (45%), Gaps = 88/380 (23%)
Query 202 FFNPATRSRIVYFILSRVKY---QVINNV----SKFGINRLVNSGIYKAAFPLHDCKFRR 254
FF R I+ F L ++ + ++NV + I L GI + FP+H+ +
Sbjct 159 FFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILN 218
Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314
+ L + W ++ + QPLD I Y+G KI +YFAWLG+YT ++ AV
Sbjct 219 R------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAV 264
Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374
G LY + D + +++C
Sbjct 265 FG--SVLYTFTEADQTS----------------------------RDVSC---------- 284
Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQARPEYEARCTHVVIN 432
+VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ RP++ I+
Sbjct 285 ----VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRG---IRRIS 337
Query 433 EITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNI 492
IT+ EE + W + + L + + L +A +I + + L F + +L ++
Sbjct 338 PITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLICVFILMLGCFQL--QELVLSV 388
Query 493 NGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTM 552
G + ++L ++ +++ + Y+K+A+ + + E R ++ YE L +
Sbjct 389 KGLPRLVRFLP---------KVMLALLVSVSAEGYKKLAVWLNDMENYRLESTYERHLII 439
Query 553 KMFLFQFVNYYSSCFYIAFF 572
K+ LFQFVN Y S FYI F+
Sbjct 440 KVVLFQFVNSYLSLFYIGFY 459
Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust.
Identities = 39/81 (48%), Positives = 56/81 (69%), Gaps = 0/81 (0%)
Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723
F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR DA+KL T +R + + IG
Sbjct 740 FQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQ 799
Query 724 WQPIMQGIAILAVVTNAMIIA 744
WQ +M+ + +LA+V N +I
Sbjct 800 WQKVMEAMGVLAIVVNCYLIG 820
>sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryza
sativa subsp. japonica OX=39947 GN=Os01g0706700 PE=2 SV=1
Length=665
Score = 115 bits (288), Expect = 4e-25, Method: Compositional matrix adjust.
Identities = 129/543 (24%), Positives = 212/543 (39%), Gaps = 131/543 (24%)
Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
+ RL + GI K FPLHD R+Q L R WA + QP+D I Y+
Sbjct 158 LTRLEDEGIVKLVFPLHDEIKRKQ------------LLRSWALKWFDFTWQPIDEIYSYF 205
Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
G KI IYF++LG YT+ L AV G+A
Sbjct 206 GTKIAIYFSFLGMYTRWLFFPAVFGLAT-------------------------------- 233
Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLV---FAVFMGVWVTLFLEFWKRRQAELEYEWD 408
+L F S LV F F+ W FL+FWKR+ + + W
Sbjct 234 -----------------QLIDFGSLQWLVLPAFFFFVISWAVFFLQFWKRKNSAVLARWG 276
Query 409 TVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIA 468
+ EY+ + + ++ + +G ++ +F +LL I
Sbjct 277 I------NYSFSEYKTMGNELDPLSFSMADDNVQQRKFGAPKEKSIVQRNEWFGVLLRIR 330
Query 469 S----VIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILN 524
+ V+ II +L + ++ I T+ ++ LT + I
Sbjct 331 NNAIIVLAIICLQLPFELAYAHLYA--ITKTEALRYVLTA----------VYLAAIQYYT 378
Query 525 TIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPV 584
I KV++ + +E + + +SL K+F F+ Y FY A
Sbjct 379 RIGGKVSVTLIKYENNQGEQSSADSLVYKVFGLYFMQSYIGLFYHA-------------- 424
Query 585 YWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV----- 639
+RN ++ L L + + N+ E +P++ ++ V
Sbjct 425 ---SLHRN--------IMALRQVLIKRLIVSQVLENLIENSIPYLNYSYKKYRAVHKKKH 473
Query 640 ------SGSEKITPRWEQDYHLQP-----MGKL---GLFYEYLEMIIQFGFVTLFVASFP 685
S +++ R E++Y L+P +G+ GLF ++LE+ +QFG + +F +FP
Sbjct 474 EKESPAGKSVRLSTRVEKEY-LKPSYTASIGEELEDGLFDDFLELTLQFGMIMMFACAFP 532
Query 686 LAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAF 745
A +NN+ EIR DA KL +R P A IGAW I Q + ++A+ TN +++
Sbjct 533 SIFCFAALNNVTEIRADALKLLVMLKRPAPRDAATIGAWLNIFQFLVVMAICTNCLLLVC 592
Query 746 TSD 748
D
Sbjct 593 LYD 595
>sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabidopsis
thaliana OX=3702 GN=At1g73020 PE=1 SV=1
Length=665
Score = 102 bits (253), Expect = 7e-21, Method: Compositional matrix adjust.
Identities = 139/553 (25%), Positives = 221/553 (40%), Gaps = 151/553 (27%)
Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291
+ RL + G+ K FPLHD R++ L + WA QP+D I Y+
Sbjct 145 LRRLESEGVIKQMFPLHDELKRKE------------LLQNWALNWWNCTNQPIDQIYSYF 192
Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
G KIG+YF++LG YTQ L+ A L G++ Q
Sbjct 193 GAKIGVYFSFLGMYTQWLIFPA-------LLGFIVQ------------------------ 221
Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVF----AVFMG--VWVTLFLEFWKRRQAELEY 405
FG+L F + F+G +W LFL+FWKR+ A L
Sbjct 222 ---------------------MVDFGSLQFLALPSFFVGTILWAALFLQFWKRKNAALLA 260
Query 406 EWDTVELQQEEQ---------ARPEYEARCTHVVINEITQEEE---RIPFTAWGKCIRIT 453
W L Q + + + NE +E+E R + A+ K R
Sbjct 261 RWQINCLVGPSQGYRFLGMEWSSLPFPKELIKNLGNERAKEKEAYQRYEWFAYRKRFRND 320
Query 454 LCASAVFFWILLIIASVIGI-IVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITA 512
+ L+I S+I + + + L+ +F I +D I+ LT
Sbjct 321 V----------LVIMSIICLQLPFELAYAHIF------EIITSDIIKYVLTA-------- 356
Query 513 SIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFF 572
I +II L + KV++ + N E+ + NSL K+F F+ Y FY
Sbjct 357 --IYLLIIQYLTRLGGKVSVKLINREINESVEYRANSLIYKVFGLYFMQTYIGIFYHVLL 414
Query 573 KGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL 632
F+ L ++ Q II + W + + LP++
Sbjct 415 HRNFM----------------------TLRQVLIQRLII--SQVFWT-LMDGSLPYLKYS 449
Query 633 IGRFH----------RVSGSEKITPRWEQDY----HLQPMG---KLGLFYEYLEMIIQFG 675
++ +G +I R E++Y + +G + GLF + LE+ +QFG
Sbjct 450 YRKYRARTKKKMEDGSSTGKIQIASRVEKEYFKPTYSASIGVELEDGLFDDSLELALQFG 509
Query 676 FVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 735
+ +F +FPLA LA V+N++EIR +A KL RR +P A IGAW I Q + +++
Sbjct 510 MIMMFACAFPLAFALAAVSNVMEIRTNALKLLVTLRRPLPRAAATIGAWLNIWQFLVVMS 569
Query 736 VVTNAMIIAFTSD 748
+ TN+ ++ D
Sbjct 570 ICTNSALLVCLYD 582
>sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=pi030
PE=4 SV=1
Length=668
Score = 100 bits (249), Expect = 2e-20, Method: Compositional matrix adjust.
Identities = 108/484 (22%), Positives = 198/484 (41%), Gaps = 104/484 (21%)
Query 380 VFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEE 439
+FA+ + +W F++FW+ ++ +L W TV Q ++ E++ + V +
Sbjct 212 IFAIGVALWGAFFIQFWRVQEHKLTNHWSTVNCQSLAKSMTEFKPQSYRV---DSLLGTA 268
Query 440 RIPFTAWGKCIRITLCASAVFF---WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTD 496
R + W +R T+ +F ILL + ++ I+ LS V+S L
Sbjct 269 RPYYPQWEIIVRSTIANVPLFLISGCILLFLIAIAFIVDVTLSE--VYSGPL-------- 318
Query 497 PIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFL 556
++ S+ +++ ++ + IY VA +T E RT+TD++ SL+ KMFL
Sbjct 319 --------KSIVSLLPAVVFQVLTLPFTFIYSIVAERLTKLENRRTKTDFQASLSGKMFL 370
Query 557 FQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL--------LELTTQL 608
F+ Y++ F I++ G F Y P Y + G L L Q
Sbjct 371 QNFMLSYTALFLISYIYGPFAEY-FVPHYIQNRMSQSFFSVGYIAKSTFKLNPLRLRNQY 429
Query 609 TIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQ--PMGKLGL--- 663
+ + N I + +P +++ + + H +S + + H+Q P + L
Sbjct 430 IYFLTNAQVINYITILAVPQLISYVKK-HYMSKPTR-------ELHIQDIPSETVTLKRA 481
Query 664 -----------FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712
+ +Y + ++ FGF+ +F +PLAP+ +LVN +L IR ++ T ++
Sbjct 482 RSEAEKIEYDCYNDYKDFVLMFGFLVMFSPIYPLAPIFSLVNCVLYIRSSVYRFTKMVKK 541
Query 713 LVPEKAQDIGAWQPIMQGIAILAVVT----------------NAMIIA------------ 744
VP + I W + ++ L +T +M+IA
Sbjct 542 PVPCRVDSIAPWDQRLSLLSWLGCITMPSICYFYSSTTKPSDKSMVIAAVIGLLSEHLWF 601
Query 745 ----FTSDMIP-------------RLVYYWSFSVPPYGDHTSYTMEGY--INNTLSIFKV 785
F S + P L+ SFS+PP D + T + + TLSI++
Sbjct 602 LLRMFISSVFPVDKTFFAPAKERQHLLAERSFSIPPVADVPTSTTTAFEEADETLSIYRT 661
Query 786 ADFK 789
A+ K
Sbjct 662 AENK 665
>sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=IST2 PE=1 SV=2
Length=946
Score = 41.2 bits (95), Expect = 0.052, Method: Compositional matrix adjust.
Identities = 36/153 (24%), Positives = 63/153 (41%), Gaps = 29/153 (19%)
Query 633 IGRFHRVSGSEKITPRWEQ--DYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPL 689
IG+ S KI W + Y P G L + ++++QFG++ +F +PLAP
Sbjct 407 IGKAQLSSSDMKI---WSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVMFSTIWPLAPF 463
Query 690 LALVNNILEIRVDAWK-------------LTTQFRRLVPEKAQDIGAWQPIMQGIAILAV 736
+ L+ N++ +VD K + + + + +G W ++ +IL
Sbjct 464 ICLIVNLIVYQVDLRKAVLYSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGC 523
Query 737 VTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS 769
V A + Y S ++P G HTS
Sbjct 524 VITATLTYM----------YQSCNIPGVGAHTS 546
>sp|Q2S8D3|F16PA_HAHCH Fructose-1,6-bisphosphatase class 1 OS=Hahella
chejuensis (strain KCTC 2396) OX=349521 GN=fbp PE=3
SV=1
Length=336
Score = 35.4 bits (80), Expect = 2.2, Method: Compositional matrix adjust.
Identities = 32/106 (30%), Positives = 44/106 (42%), Gaps = 8/106 (8%)
Query 547 ENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYR-NEECDPGGCLLELT 605
E+ T + + +++ S F+ KG YP Y GK R EC+P L+E
Sbjct 232 EDDATQRPYTSRYIGSLVSDFHRNLIKGGIYLYPTSSRYPEGKLRLLYECNPMAFLIEQA 291
Query 606 TQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQ 651
GGKAI N Q +L L R GS K+ + EQ
Sbjct 292 -------GGKAIANPGQRILDIEPTKLHQRCPLFVGSPKMVDKLEQ 330
>sp|Q9VNS0|MAEL_DROME Protein maelstrom OS=Drosophila melanogaster
OX=7227 GN=mael PE=1 SV=1
Length=459
Score = 34.7 bits (78), Expect = 4.5, Method: Compositional matrix adjust.
Identities = 27/89 (30%), Positives = 38/89 (43%), Gaps = 15/89 (17%)
Query 83 TNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHI 142
+ K N QR KR++ + Q EAT S++D K E L A++ H
Sbjct 52 SGGKDANVAQRAKRESSNGHGQVDKAQREATESLMDMKRTI-------ERLVLNAKMSH- 103
Query 143 KLPLKPNDLKNRSSAFGTLNWFTKVLSVD 171
DL+N F N+FTK L+ D
Sbjct 104 -------DLENAKFVFVAFNYFTKALTTD 125
>sp|Q12202|OSW2_YEAST Outer spore wall protein 2 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=OSW2
PE=4 SV=2
Length=724
Score = 34.3 bits (77), Expect = 5.9, Method: Compositional matrix adjust.
Identities = 24/86 (28%), Positives = 38/86 (44%), Gaps = 10/86 (12%)
Query 260 SCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVAC 319
S P E Y Y + +P I QP+ L +KY + F + G+YT++L L+ +
Sbjct 325 SLPFEPYCFYHRFEYPAQILLHQPIILAKKYGVSCSNLNFLY-GFYTRLLTLSGLS---- 379
Query 320 FLYGYLNQDNCTWSKEVCHPDIGGKI 345
+N C + + IGG I
Sbjct 380 -----INGGRCEHALSMLDSRIGGGI 400
>sp|Q1KXV4|NU3C_HELAN NAD(P)H-quinone oxidoreductase subunit 3,
chloroplastic OS=Helianthus annuus OX=4232 GN=ndhC PE=3 SV=1
Length=120
Score = 32.3 bits (72), Expect = 7.4, Method: Composition-based stats.
Identities = 17/42 (40%), Positives = 28/42 (67%), Gaps = 4/42 (10%)
Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNI----NGTDPI 498
FW LII+S+I I+V+ +S F+ S+K P+ + +G +PI
Sbjct 10 FWAFLIISSLIPILVFFISGFLAPSSKGPEKLSSYESGIEPI 51
>sp|B2LMJ8|NU3C_GUIAB NAD(P)H-quinone oxidoreductase subunit 3,
chloroplastic OS=Guizotia abyssinica OX=4230 GN=ndhC PE=3
SV=1
Length=120
Score = 32.3 bits (72), Expect = 7.4, Method: Composition-based stats.
Identities = 17/42 (40%), Positives = 28/42 (67%), Gaps = 4/42 (10%)
Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNI----NGTDPI 498
FW LII+S+I I+V+ +S F+ S+K P+ + +G +PI
Sbjct 10 FWAFLIISSLIPILVFFISGFLAPSSKGPEKLSSYESGIEPI 51
>sp|Q6R799|Y120_OSHVF Uncharacterized protein ORF120 OS=Ostreid
herpesvirus 1 (isolate France) OX=654903 GN=ORF120 PE=3 SV=1
Length=76
Score = 30.8 bits (68), Expect = 8.6, Method: Composition-based stats.
Identities = 11/19 (58%), Positives = 12/19 (63%), Gaps = 0/19 (0%)
Query 347 MCPQCDRLCPFWKLNITCE 365
+C CDRLCP N TCE
Sbjct 44 ICQDCDRLCPLISDNPTCE 62
Lambda K H a alpha
0.324 0.140 0.435 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 105757600374
Results from round 2
Query= sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6
PE=1 SV=2
Length=910
Score E
Sequences producing significant alignments: (Bits) Value
Sequences used in model and found again:
sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 ... 1259 0.0
sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6... 1225 0.0
sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5... 1068 0.0
sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 ... 1065 0.0
sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4... 1047 0.0
sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1... 1045 0.0
sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 ... 1039 0.0
sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE... 1032 0.0
sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 ... 1028 0.0
sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 ... 990 0.0
sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3... 990 0.0
sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 ... 988 0.0
sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2... 982 0.0
sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7... 958 0.0
sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=A... 956 0.0
sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 ... 944 0.0
sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 ... 727 0.0
sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9... 686 0.0
sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO... 422 3e-135
sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=An... 421 7e-135
sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano1... 390 3e-123
sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryz... 376 1e-117
sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabido... 336 2e-102
sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosa... 312 3e-93
sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 ... 285 6e-80
sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8... 283 1e-79
Sequences not found previously or not previously below threshold:
sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Sacc... 87.9 2e-16
sp|Q9SZT4|OSC41_ARATH Hyperosmolality-gated Ca2+ permeable channe... 46.7 0.001
sp|A0RPL5|TGT_CAMFF Queuine tRNA-ribosyltransferase OS=Campylobac... 40.5 0.056
sp|B9L8E1|TGT_NAUPA Queuine tRNA-ribosyltransferase OS=Nautilia p... 39.0 0.20
sp|Q5HUF2|TGT_CAMJR Queuine tRNA-ribosyltransferase OS=Campylobac... 36.3 1.2
sp|Q1EPG7|CSPL1_MUSAC CASP-like protein 1E1 OS=Musa acuminata OX=... 35.1 1.7
sp|A7GYD5|TGT_CAMC5 Queuine tRNA-ribosyltransferase OS=Campylobac... 35.5 2.1
sp|Q5YCC5|TMC7_CHICK Transmembrane channel-like protein 7 OS=Gall... 35.1 3.4
sp|A1VZZ8|TGT_CAMJJ Queuine tRNA-ribosyltransferase OS=Campylobac... 34.7 3.5
sp|B6EK65|TGT_ALISL Queuine tRNA-ribosyltransferase OS=Aliivibrio... 34.7 3.5
sp|Q96NT0|VMA22_HUMAN Vacuolar ATPase assembly protein VMA22 OS=H... 34.0 3.6
sp|Q8VZM5|OSC16_ARATH Hyperosmolality-gated Ca2+ permeable channe... 34.7 4.6
sp|Q5YCC7|TMC3_CHICK Transmembrane channel-like protein 3 OS=Gall... 34.7 4.7
sp|Q62812|MYH9_RAT Myosin-9 OS=Rattus norvegicus OX=10116 GN=Myh9... 34.7 5.1
sp|Q9ULH1|ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH ... 34.7 5.3
sp|Q8VDD5|MYH9_MOUSE Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE... 34.3 6.4
>sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6
PE=1 SV=2
Length=910
Score = 1259 bits (3258), Expect = 0.0, Method: Composition-based stats.
Identities = 910/910 (100%), Positives = 910/910 (100%), Gaps = 0/910 (0%)
Query 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL
Sbjct 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60
Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK
Sbjct 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180
LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE
Sbjct 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180
Query 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240
FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI
Sbjct 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240
Query 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA
Sbjct 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL
Sbjct 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420
NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP
Sbjct 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420
Query 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480
EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV
Sbjct 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480
Query 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540
FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP
Sbjct 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540
Query 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600
RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC
Sbjct 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600
Query 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660
LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK
Sbjct 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660
Query 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720
LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD
Sbjct 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720
Query 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780
IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL
Sbjct 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780
Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV
Sbjct 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900
MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA
Sbjct 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900
Query 901 VDNNLRPKSE 910
VDNNLRPKSE
Sbjct 901 VDNNLRPKSE 910
>sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6
PE=1 SV=1
Length=911
Score = 1225 bits (3169), Expect = 0.0, Method: Composition-based stats.
Identities = 821/912 (90%), Positives = 863/912 (95%), Gaps = 3/912 (0%)
Query 1 MKKMSRNVLLQMEEEEDDDDGD-IVLENLGQTIV-PDLGSLESQHDFRTPEFEEFNGKPD 58
M+ M+R VLL ME EEDDD+ IVLEN QTIV P GSLE+Q DFRTPEFEEFNGKPD
Sbjct 1 MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPD 60
Query 59 SLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLD 118
SLFF DGQRRIDF+LVYEDES+KE NKKGTNEKQ+RKRQAYESNLICHGLQLEATRSV D
Sbjct 61 SLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSD 120
Query 119 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178
DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK RS FG LNWFTKVL V+ES+IKPE
Sbjct 121 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSP-FGNLNWFTKVLRVNESVIKPE 179
Query 179 QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNS 238
QEFFTAPFEK+RMNDFYI+DRD+FFNPATRSRIVYFILSRVKYQV+NNV+KFGINRLV+S
Sbjct 180 QEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSS 239
Query 239 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 298
GIYKAAFPLHDC+F +SED SCP+ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY
Sbjct 240 GIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 299
Query 299 FAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFW 358
FAWLGYYTQMLLLAAVVGVACFLYGYL+QDNCTWSKEVC PDIGG+I+MCPQCDRLCPFW
Sbjct 300 FAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFW 359
Query 359 KLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 418
+LNITCESSKKLCIFDSFGTL+FAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA
Sbjct 360 RLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 419
Query 419 RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478
RPEYEA+C HVVINEITQEEERIPFT GKCIR+TLCASAVFFWILLIIASVIGIIVYRL
Sbjct 420 RPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRL 479
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
SVFIVFS LPKN NGTDPIQKYLTPQ ATSITASIISFIIIMILNTIYEKVAIMITNFE
Sbjct 480 SVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFE 539
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVY LGKYR+EECDPG
Sbjct 540 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPG 599
Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPM 658
GCLLELTTQLTIIMGGKAIWNNIQEVLLPW+MNLIGR+ RVSGSEKITPRWEQDYHLQPM
Sbjct 600 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPM 659
Query 659 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718
GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR+VPEKA
Sbjct 660 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKA 719
Query 719 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINN 778
QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS+PPYGDHT YTM+GYINN
Sbjct 720 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINN 779
Query 779 TLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFI 838
TLS+F + DFKN K NPY LGN+T CRYRDFR PPGHPQEYKHNIYYWHVIAAKLAFI
Sbjct 780 TLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFI 839
Query 839 IVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMI 898
IVMEH+IYSVKFFISYAIPDVSK TKSKI+REKYLTQKLLHE+HLKD+TKNMG+IAER+
Sbjct 840 IVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIG 899
Query 899 EAVDNNLRPKSE 910
VDN++RPK E
Sbjct 900 GTVDNSVRPKLE 911
>sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5
PE=2 SV=1
Length=904
Score = 1068 bits (2762), Expect = 0.0, Method: Composition-based stats.
Identities = 435/902 (48%), Positives = 595/902 (66%), Gaps = 45/902 (5%)
Query 34 PDLGSLESQ----HDFRTPEFEEFN-------------GKPDSLFFNDGQRRIDFVLVYE 76
+LGS E+ D ++P + FN DS+FF DG R+IDFVL Y
Sbjct 20 ENLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYV 79
Query 77 DESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV--LDDKLVFVKVHAPWEVLC 134
++ +K+ E + +R+ +E NL GL LE + D K FVK+HAPWEVL
Sbjct 80 EDLKKD------GELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLV 133
Query 135 TYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDF 194
TYAE++ IK+P+K +D+ + L++ + + S+ P E+FTA F ++R F
Sbjct 134 TYAEVLGIKMPIKLSDIPRPK--YPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELF 191
Query 195 YIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRR 254
I D FF +TR+RIVY+ILSR + V K GI RL+NS Y +A+PLHD ++ +
Sbjct 192 LIEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWK 251
Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314
S+ PNERY L + WA YK+QP LIR Y+GEKIGIYF +LGYYT+MLL AA+
Sbjct 252 PSKTT-RPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAAL 310
Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374
VG+ACF+YG L+ +N S E+C PDIGG++IMCP CD +C +W+LN TC SK +FD
Sbjct 311 VGLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFD 370
Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA---RPEYEARCTHVVI 431
+ T+ FA+FMG+WVTLFLEFWK+RQA LEYEWD V+ ++E+Q RPE+EA C H +
Sbjct 371 NESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKM 430
Query 432 NEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKN 491
N +T+E E + + + V F + L+++S++ I++YRLSVF F++ +
Sbjct 431 NPVTKEMEPH-MPLCHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFMESE 489
Query 492 INGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLT 551
++ + TPQ AT+++ S ++ I+I+ILN YEK++ IT E+PRT +YE+SLT
Sbjct 490 AT-LQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYESSLT 548
Query 552 MKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTII 611
+KMFLFQFVNYYSSCFY+AFFKGKFVGYPG Y +R+EEC P GCL+ELTTQLTII
Sbjct 549 LKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTII 608
Query 612 MGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMI 671
M GK I+ NI E P I N R + SEK+ RWEQD+ LQ G GLFYEYLE +
Sbjct 609 MIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYLETV 668
Query 672 IQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGI 731
IQFGF TLFVASFPLAPL AL+NNI+ IRVDAWKLTTQ+RR V KA IG WQ I+ G+
Sbjct 669 IQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILFGM 728
Query 732 AILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNK 791
AI++V TNA I++FTSD+IPRLVY++++S +++ + GY+NN+LS+F +ADF N
Sbjct 729 AIVSVATNAFIVSFTSDIIPRLVYFYAYST-----NSTEPLSGYVNNSLSVFLIADFPNH 783
Query 792 SKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFF 851
+ D TCRYRD+RYPP H +Y HN+ +WHV+AAK+ FIIVMEHV++ KF
Sbjct 784 TVPMEKKDF---VTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFL 840
Query 852 ISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM----GVIAERMIEAVDNNLRP 907
+++ IPDV K KI+REK +T K++H+ L + +N+ G I + ++ DN+L+
Sbjct 841 LAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNSLKA 900
Query 908 KS 909
K+
Sbjct 901 KT 902
>sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5
PE=1 SV=1
Length=913
Score = 1065 bits (2754), Expect = 0.0, Method: Composition-based stats.
Identities = 433/852 (51%), Positives = 597/852 (70%), Gaps = 23/852 (3%)
Query 46 RTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLIC 105
R F++ DS+FF DG R+IDFVL Y D+ +K+ E + +R+ +E+NL
Sbjct 57 RRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDA------ELKAERRKEFETNLRK 110
Query 106 HGLQLEAT--RSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNW 163
GL+LE R D + FVK+HAPWEVL TYAE++ IK+P+K +D+ +++
Sbjct 111 TGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHT--PISY 168
Query 164 FTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223
+ + S+ P E+FTA F ++R F I D+ FF ++R+RIVY+ILSR + +
Sbjct 169 VLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGI 228
Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQP 283
+ +FGI RL+NS Y +A+PLHD ++ + SE P+ NERY L++ WA YK+QP
Sbjct 229 EDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQP 288
Query 284 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGG 343
LDLI+ YYGEKIGIYF +LG+YT+ML AAVVG+ACF+YG L+ ++ T S E+C P+IGG
Sbjct 289 LDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGG 348
Query 344 KIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAEL 403
++IMCP CD++C +W+LN TC +SK +FD+ T+ FA+FMG+WVTLFLEFWK+RQA L
Sbjct 349 QMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARL 408
Query 404 EYEWDTVELQQEEQA---RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVF 460
EYEWD V+ ++E+Q RPE+EA C H +N +T+E E + + L + V
Sbjct 409 EYEWDLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEP-YMPLYTRIPWYFLSGATVT 467
Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIII 520
W+ L++ S++ +IVYRLSVF F++ + + + ++ +LTPQ TS+T S ++FI+I
Sbjct 468 LWMSLVVTSMVAVIVYRLSVFATFASFMESDAS-LKQVKSFLTPQITTSLTGSCLNFIVI 526
Query 521 MILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 580
+ILN YEK++ IT E+PRT +YE+SLT+KMFLFQFVN+YSSCFY+AFFKGKFVGYP
Sbjct 527 LILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYP 586
Query 581 GDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVS 640
G Y ++R+EECDPGGCL+ELTTQLTIIM GK I+ NI+E + P +N R +
Sbjct 587 GKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKART 646
Query 641 GSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIR 700
SEK+ RWEQD+ L+ G LGLFYEYLE + QFGFVTLFVASFPLAPLLAL+NNI+EIR
Sbjct 647 NSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIR 706
Query 701 VDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS 760
VDAWKLTTQ+RR V KA IG WQ I+ G+A+L+V TNA I+AFTSD+IPRLVYY+++S
Sbjct 707 VDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYS 766
Query 761 VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQE 820
+ + M GY+NN+LS+F +ADF N + + D TCRYRD+RYPP +
Sbjct 767 T-----NATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDF---ITCRYRDYRYPPDDENK 818
Query 821 YKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHE 880
Y HN+ +WHV+AAK+ FIIVMEHV++ VKF +++ IPDV K +I+REK +T K+LH+
Sbjct 819 YFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHD 878
Query 881 NHLKDMTKNMGV 892
L + +N+G+
Sbjct 879 FELNKLKENLGI 890
>sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4
PE=1 SV=2
Length=955
Score = 1047 bits (2707), Expect = 0.0, Method: Composition-based stats.
Identities = 398/927 (43%), Positives = 578/927 (62%), Gaps = 62/927 (7%)
Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54
+++M+++V + +E E DDD + NL T D LE+ + E N
Sbjct 51 IQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SEDTSRLEAGGE----TVRERN 105
Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114
K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E
Sbjct 106 -KSNGLYFRDGKCRIDYILVYR-----------KSNPQTEKREVFERNIRAEGLQMEKES 153
Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164
S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F
Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213
Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221
K + +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY
Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKY 273
Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279
+ +K G+NRL+ +G Y+AAFPLH+ +R ++ + N R+LLY WA Y
Sbjct 274 E--EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWGVWY 331
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+C SKEVC
Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVC-- 389
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR
Sbjct 390 -QATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448
Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457
+A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E KC R+ + AS
Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFT-DKCSRLIVSAS 507
Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517
+FF I ++IA+V GI++YR+ F+A Q AT+ TA I+F
Sbjct 508 GIFFMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINF 559
Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577
IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F
Sbjct 560 CIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFT 619
Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GR 635
G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N +
Sbjct 620 GHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRK 679
Query 636 FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693
+ G+E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+
Sbjct 680 VRQEHGTERKINFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALL 739
Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753
NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRL
Sbjct 740 NNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRL 799
Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYR 809
VY + + G+ M GY+N +LS+F+++DF+N+S+ CRYR
Sbjct 800 VYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYR 859
Query 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 869
D+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++R
Sbjct 860 DYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRR 919
Query 870 EKYLTQKLLHENHLKDMTKNMGVIAER 896
EKYL Q++++E L+ + K +
Sbjct 920 EKYLIQEMMYEAELERLQKERKERKKN 946
>sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1
PE=1 SV=2
Length=960
Score = 1045 bits (2703), Expect = 0.0, Method: Composition-based stats.
Identities = 356/960 (37%), Positives = 526/960 (55%), Gaps = 101/960 (11%)
Query 19 DDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPD-----SLFFNDGQRRIDFVL 73
+D + + N+ + DLG L S+ + PD L+F DG+R++D++L
Sbjct 13 EDRSVHIVNI--CAIEDLGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGKRKVDYIL 66
Query 74 VYE---------------------------------------DESRKETNKKGTNEKQRR 94
VY D E + +R
Sbjct 67 VYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRF 126
Query 95 KRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNR 154
+R+ YE NL+ GL+LE + FVK+HAPW VLC AE + +K+P K + +
Sbjct 127 RREEYEGNLLEAGLELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTK--KVYHI 184
Query 155 SSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPA 206
S G L VL I+P+ + + PF + + + F + DRD+FF+
Sbjct 185 SETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSK 244
Query 207 TRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERY 266
TRS IVY IL R GI L+ +G+Y AA+PLHD + + + N+R
Sbjct 245 TRSTIVYEILKRT--TCTKAKYSMGITSLLANGVYSAAYPLHDGDYEGDNVEF---NDRK 299
Query 267 LLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLN 326
LLY EWA YK QP+DL+RKY+GEK+G+YFAWLG YTQML+ A++VGV FLYG
Sbjct 300 LLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCAT 359
Query 327 QDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMG 386
D S E+C D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM
Sbjct 360 VDENIPSMEMC--DQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMA 417
Query 387 VWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINEIT--QEEE 439
+W F+E WKR+Q L Y WD ++EE+ R EYEAR + + + +E +
Sbjct 418 LWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETD 477
Query 440 RIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQ 499
++ T + ++ F I + A V+G+I+YR+S + +N + ++
Sbjct 478 KVKLTWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALA------MNSSPSVR 531
Query 500 KYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQF 559
+ + + TA II+ ++I++L+ +Y +A +T E+P+T+ +E LT K FL +F
Sbjct 532 SNI--RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKF 589
Query 560 VNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA-IW 618
VN Y+ FY+AFFKG+FVG PGD VY +R EEC PGGCL+EL QL+IIM GK I
Sbjct 590 VNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQ 649
Query 619 NNIQEVLLPWIMNLIG--RFHRVSGSE-----KITPRWEQDYHLQPMGKLGLFYEYLEMI 671
NN+ E+ +P + I + R S S+ K R+E D++L+P GL EY+EMI
Sbjct 650 NNLFEIGIPKMKKFIRYLKLRRQSPSDREEYVKRKQRYEVDFNLEPFA--GLTPEYMEMI 707
Query 672 IQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGI 731
IQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K T+ RR V +A+DIG W I++G+
Sbjct 708 IQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGV 767
Query 732 AILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNK 791
LAV+ NA +I+FTSD IPRLVY + +S + TM G++N+TLS F V+DF+N
Sbjct 768 GKLAVIINAFVISFTSDFIPRLVYLYMYS-------QNGTMHGFVNHTLSSFNVSDFQNG 820
Query 792 SKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKF 850
+ N DLG CRY+D+R PP +Y + +W V+AA+LAF+IV ++++ +
Sbjct 821 TAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSD 880
Query 851 FISYAIPDVSKRTKSKIQREKYLTQKL-LHENHLKDMTKNMGVIAERMIEAVDNNLRPKS 909
F+ + IPD+ K +I +EK L +L + E K + + E+ + NN P +
Sbjct 881 FVDWVIPDIPKDISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTT 940
>sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4
PE=1 SV=1
Length=955
Score = 1039 bits (2686), Expect = 0.0, Method: Composition-based stats.
Identities = 396/927 (43%), Positives = 575/927 (62%), Gaps = 62/927 (7%)
Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54
+++M+++V + +E E DDD + NL T D LE+ + E N
Sbjct 51 IQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTST-SDDASRLEAGGE----TVPERN 105
Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114
K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E
Sbjct 106 -KSNGLYFRDGKCRIDYILVYR-----------KSNPQTEKREVFERNIRAEGLQMEKES 153
Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164
S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F
Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213
Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221
K + +D+ + E + +TAPF + R++ F I +++ FFN ATRSRIV+ IL R+KY
Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKY 273
Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279
+ +K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA Y
Sbjct 274 E--EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWY 331
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+ SKEVC
Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVC-- 389
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR
Sbjct 390 -QATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448
Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457
+A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E KC R+ + AS
Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFT-DKCSRLIVSAS 507
Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517
+FF I ++IA+V GI++YR+ F+A Q AT+ TA I+F
Sbjct 508 GIFFMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINF 559
Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577
IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F
Sbjct 560 CIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFT 619
Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GR 635
G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N +
Sbjct 620 GHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRK 679
Query 636 FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693
+ G E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+
Sbjct 680 VRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALL 739
Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753
NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRL
Sbjct 740 NNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRL 799
Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYR 809
VY + + G+ M GY+N +LS+F+++DF+N+S+ CRYR
Sbjct 800 VYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYR 859
Query 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 869
D+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++R
Sbjct 860 DYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRR 919
Query 870 EKYLTQKLLHENHLKDMTKNMGVIAER 896
EKYL Q++++E L+ + K +
Sbjct 920 EKYLIQEMMYEAELERLQKERKERKKN 946
>sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4
PE=2 SV=1
Length=920
Score = 1032 bits (2669), Expect = 0.0, Method: Composition-based stats.
Identities = 398/924 (43%), Positives = 575/924 (62%), Gaps = 62/924 (7%)
Query 4 MSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKP 57
++++V + +E E DDD + NL T D LE+ + PE + N
Sbjct 19 VAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SDDASRLEAGGE-TVPEKNKLN--- 73
Query 58 DSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVL 117
L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E S++
Sbjct 74 -GLYFRDGKCRIDYILVYR-----------KSNPQMEKREVFERNIRAEGLQMEKESSLI 121
Query 118 DDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF-----TK 166
+ ++FVK+HAPWEVL YAE M++++P + P K S ++ F K
Sbjct 122 NSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKK 181
Query 167 VLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVI 224
+ +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY+
Sbjct 182 PMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYE-- 239
Query 225 NNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIYKKQ 282
+K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA YK Q
Sbjct 240 EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQ 299
Query 283 PLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIG 342
PLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG + D+C SKEVC
Sbjct 300 PLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVC---QA 356
Query 343 GKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAE 402
IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR+A
Sbjct 357 TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAV 416
Query 403 LEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAVF 460
+ Y+WD ++ ++EE+ RP++EA+ + +N I+ + E A KC R+ + AS +F
Sbjct 417 IAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFA-DKCSRLIVSASGIF 475
Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIII 520
F I ++IA+V GI++YR+ F+A Q AT+ TA I+F II
Sbjct 476 FMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINFCII 527
Query 521 MILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 580
M+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F G+P
Sbjct 528 MLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHP 587
Query 581 GDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GRFHR 638
G + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N + +
Sbjct 588 GAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQ 647
Query 639 VSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNI 696
G E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+NNI
Sbjct 648 EHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNI 707
Query 697 LEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYY 756
+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRLVY
Sbjct 708 IEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYA 767
Query 757 WSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYRDFR 812
+ + G+ M GY+N +LS+F+++DF+N+S+ CRYRD+R
Sbjct 768 YKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYR 827
Query 813 YPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872
PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++REKY
Sbjct 828 DPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKY 887
Query 873 LTQKLLHENHLKDMTKNMGVIAER 896
L Q++++E L+ + K +
Sbjct 888 LIQEMMYEAELERLQKERKERKKN 911
>sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1
PE=1 SV=1
Length=986
Score = 1028 bits (2659), Expect = 0.0, Method: Composition-based stats.
Identities = 353/986 (36%), Positives = 525/986 (53%), Gaps = 128/986 (13%)
Query 19 DDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPD-----SLFFNDGQRRIDFVL 73
+D + + N+ + D+G L S+ + PD L+F DG+R++D++L
Sbjct 13 EDRSVHIINI--CAIEDIGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGRRKVDYIL 66
Query 74 VYE---------------------------------------DESRKETNKKGTNEKQRR 94
VY D E + +R
Sbjct 67 VYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRF 126
Query 95 KRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNR 154
+R+ YE NL+ GL+LE + FVK+HAPW VLC AE + +K+P K + +
Sbjct 127 RREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTK--KMYHI 184
Query 155 SSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPA 206
+ G L VL I+P+ + + PF + + + F + D+D+FF+
Sbjct 185 NETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSK 244
Query 207 TRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERY 266
TRS IVY IL R GI L+ +G+Y AA+PLHD + ++ + N+R
Sbjct 245 TRSTIVYEILKRT--TCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEF---NDRK 299
Query 267 LLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLN 326
LLY EWA YK QP+DL+RKY+GEKIG+YFAWLG YTQML+ A++VG+ FLYG
Sbjct 300 LLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCAT 359
Query 327 QDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMG 386
D S E+C D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM
Sbjct 360 MDENIPSMEMC--DQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMA 417
Query 387 VWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINEITQEEER- 440
+W F+E WKR+Q L Y WD ++EE+ R EYEAR + + ++ +E+
Sbjct 418 LWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKR 477
Query 441 ---------------------------IPFTAWGKCIRITLCASAVFFWILLIIASVIGI 473
+ T + ++ F I + A V+G+
Sbjct 478 RHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGV 537
Query 474 IVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIM 533
I+YR+S+ + +N + ++ + + + TA II+ ++I++L+ +Y +A
Sbjct 538 IIYRISMAAALA------MNSSPSVRSNI--RVTVTATAVIINLVVIILLDEVYGCIARW 589
Query 534 ITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNE 593
+T E+P+T+ +E L K FL +FVN Y+ FY+AFFKG+FVG PGD VY +R E
Sbjct 590 LTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRME 649
Query 594 ECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIG--RFHRVSGSE-----KI 645
EC PGGCL+EL QL+IIM GK I NN+ E+ +P + LI + + S + K
Sbjct 650 ECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKR 709
Query 646 TPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWK 705
R+E DY+L+P GL EY+EMIIQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K
Sbjct 710 KQRYEVDYNLEPFA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKK 767
Query 706 LTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYG 765
T+ RR V +A+DIG W I++GI LAV+ NA +I+FTSD IPRLVY + +S
Sbjct 768 FVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYS----- 822
Query 766 DHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHN 824
+ TM G++N+TLS F V+DF+N + N DLG CRY+D+R PP +Y +
Sbjct 823 --KNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDIS 880
Query 825 IYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKL-LHENHL 883
+W V+AA+LAF+IV ++++ + F+ + IPD+ K +I +EK L +L + E
Sbjct 881 KDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQD 940
Query 884 KDMTKNMGVIAERMIEA-VDNNLRPK 908
K + ER + N+ K
Sbjct 941 KQQLLETWMEKERQKDEPPCNHHNTK 966
>sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3
PE=1 SV=2
Length=981
Score = 990 bits (2559), Expect = 0.0, Method: Composition-based stats.
Identities = 371/853 (43%), Positives = 524/853 (61%), Gaps = 58/853 (7%)
Query 57 PDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV 116
F DG++RID++LVY Q KR +E NL GL LE ++
Sbjct 152 SSGPLFKDGKKRIDYILVYR-----------KTNIQYDKRNTFEKNLRAEGLMLEKEPAI 200
Query 117 LDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKN--RSSAFGTL--------NWFTK 166
++F+K+H PW+ LC YAE ++I++P + RS + G + NW +
Sbjct 201 ASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQ 260
Query 167 VLSVDESIIKP---EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223
V + P E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+
Sbjct 261 NPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319
Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR--QSEDPSCPNERYLLYREWAHPRSIYKK 281
N +SK GI +L+N+G Y AAFP H+ ++ + N R+LLY WA YK
Sbjct 320 -NGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKH 378
Query 282 QPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDI 341
QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AA+VG+ F YG +N S+E+C
Sbjct 379 QPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICK--- 435
Query 342 GGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQA 401
++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++
Sbjct 436 ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRS 495
Query 402 ELEYEWDTVELQQEEQA-RPEYEARCTHVVI-NEITQEEERIPFTAWGKCIRITLCASAV 459
L Y WD +E ++EE+ RP++EA+ + I N IT + E + K R+ + S +
Sbjct 496 ILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQ-PSSDKVTRLLVSVSGI 554
Query 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFII 519
FF I L+I +V G++VYRL V F++ N Q ATS A I+FII
Sbjct 555 FFMISLVITAVFGVVVYRLVVMEQFAS-FKWNFIKQYW-------QFATSAAAVCINFII 606
Query 520 IMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGY 579
IM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+
Sbjct 607 IMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH 666
Query 580 PGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV 639
PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R
Sbjct 667 PGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIK 726
Query 640 SG-SEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILE 698
G + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+E
Sbjct 727 RGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIE 786
Query 699 IRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWS 758
IR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY +
Sbjct 787 IRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK 846
Query 759 FSVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPP 815
+ P +H + ++GY+NN+LS F +++ +G CRYRD+R PP
Sbjct 847 YG--PCANHVEPSENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPP 894
Query 816 GHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQ 875
+ Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPDV K +I+REKYL Q
Sbjct 895 WSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQ 954
Query 876 KLLHENHLKDMTK 888
++++E L+ + +
Sbjct 955 EMMYEAELEHLQQ 967
>sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3
PE=1 SV=1
Length=981
Score = 990 bits (2558), Expect = 0.0, Method: Composition-based stats.
Identities = 368/853 (43%), Positives = 524/853 (61%), Gaps = 58/853 (7%)
Query 57 PDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV 116
L F DG++RID++LVY Q KR +E NL GL LE ++
Sbjct 152 SSGLLFKDGKKRIDYILVYR-----------KTNIQYDKRNTFEKNLRAEGLMLEKEPAI 200
Query 117 LDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK----NRSSAF------GTLNWFTK 166
+ ++F+K+H PW+ LC YAE ++I++P + N+S + W ++
Sbjct 201 ANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQ 260
Query 167 VLSVDESIIKPE---QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223
V + PE + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+
Sbjct 261 NPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319
Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR--QSEDPSCPNERYLLYREWAHPRSIYKK 281
N +SK GI +L+ +G Y AAFP H+ ++ + N R+LLY WA YK
Sbjct 320 -NGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKH 378
Query 282 QPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDI 341
QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AAVVG+ F YG + + S+E+C
Sbjct 379 QPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICK--- 435
Query 342 GGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQA 401
++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++
Sbjct 436 ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRS 495
Query 402 ELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAV 459
L Y WD +E ++EE+ RP++EA+ + VIN IT + E + K R+ + S +
Sbjct 496 ILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQ-PSSDKVTRLLVSVSGI 554
Query 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFII 519
FF I L+I +V ++VYRL V F++ N Q ATS A I+FII
Sbjct 555 FFMISLVITAVFAVVVYRLVVMEQFAS-FKWNFVKQHW-------QFATSGAAVCINFII 606
Query 520 IMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGY 579
IM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+
Sbjct 607 IMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH 666
Query 580 PGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV 639
PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R
Sbjct 667 PGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIK 726
Query 640 SG-SEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILE 698
G + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+E
Sbjct 727 RGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIE 786
Query 699 IRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWS 758
IR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY +
Sbjct 787 IRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK 846
Query 759 FSVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPP 815
+ P +H ++GY+NN+LS F +++ +G CRYRD+R PP
Sbjct 847 YG--PCANHVKQNENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPP 894
Query 816 GHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQ 875
+ Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPD+ K + +I+REKYL Q
Sbjct 895 WSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQ 954
Query 876 KLLHENHLKDMTK 888
++++E L+ + +
Sbjct 955 EMMYEAELEHLQQ 967
>sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2
PE=1 SV=2
Length=1003
Score = 988 bits (2555), Expect = 0.0, Method: Composition-based stats.
Identities = 327/903 (36%), Positives = 484/903 (54%), Gaps = 97/903 (11%)
Query 52 EFNGKPDSLFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTN 89
+ + F+D QR++D+VL Y E+ KE + G
Sbjct 82 SLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPG 141
Query 90 EKQRRKRQAYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAE 138
+ + A E NL+ GL+LE +FV++HAPW+VL AE
Sbjct 142 DIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAE 201
Query 139 IMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNR 190
+ IK+P K ++ + F+ L S ++P + + + PF + +
Sbjct 202 FLKIKVPTK-KEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREK 260
Query 191 MNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDC 250
M + I ++D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD
Sbjct 261 MYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDG 318
Query 251 KFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLL 310
++ +D N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+
Sbjct 319 EYDSPEDDM---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLI 375
Query 311 LAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKL 370
++V+GV FLYG + S+E+C D MCP CD+ C +W L+ C +++
Sbjct 376 PSSVIGVIVFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQAS 433
Query 371 CIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEAR 425
+FD+ T+ F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE +
Sbjct 434 HLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETK 493
Query 426 CTHVVINEITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470
++ E Q E++ T + + +++ F I L + V
Sbjct 494 VREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIV 553
Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530
G+IVYR++ S N + + TA II+ ++I+IL+ IY V
Sbjct 554 FGVIVYRITTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAV 603
Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590
A +T E+P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY Y
Sbjct 604 AKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGY 663
Query 591 RNEECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSG-------S 642
R EEC PGGCL+EL QL+IIM GK I NNI E+ +P + L + +
Sbjct 664 RMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAH 723
Query 643 EKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVD 702
K +W+ DY L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+D
Sbjct 724 SKHPEQWDLDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLD 781
Query 703 AWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVP 762
A K T+ RR + +DIG W I+ GI +V++NA +IA TSD IPRLVY +S+S
Sbjct 782 AKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS-- 839
Query 763 PYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYK 822
+ T+ G++N+TLS F V+ K ++ CR++D+R PP P Y+
Sbjct 840 -----HNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYE 894
Query 823 HNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHEN 881
+ YW +++A+LAF+I+ ++++ + + + IPD+ +I++EK L L E
Sbjct 895 FSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEE 954
Query 882 HLK 884
H K
Sbjct 955 HEK 957
>sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2
PE=1 SV=2
Length=1002
Score = 982 bits (2539), Expect = 0.0, Method: Composition-based stats.
Identities = 329/894 (37%), Positives = 482/894 (54%), Gaps = 97/894 (11%)
Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97
+ F+D QR++D+VL Y E+ KE + G + +
Sbjct 90 MHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLD 149
Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146
A E NL+ GL+LE VFV++HAPW+VL AE + IK+P
Sbjct 150 ALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPT 209
Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVD 198
K + + F+ +L S ++P + + PF + +M + I +
Sbjct 210 K--KMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQE 267
Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258
+D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D
Sbjct 268 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPGDD 325
Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318
N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV
Sbjct 326 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 382
Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378
FLYG + SKE+C D MCP CD+ C +W L+ C +++ +FD+ T
Sbjct 383 VFLYGCATIEEDIPSKEMC--DHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPAT 440
Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433
+ F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E
Sbjct 441 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKE 500
Query 434 -----ITQEEERIP---------FTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479
+ + E P T + + +++ F I L + V G+IVYR++
Sbjct 501 SGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT 560
Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539
S N + + TA II+ ++I+IL+ IY VA +T E+
Sbjct 561 TAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEV 610
Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599
P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PGG
Sbjct 611 PKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGG 670
Query 600 CLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSEKITP-------RWEQ 651
CL+EL QL+IIM GK I NNI E+ +P + L + + + P +W+
Sbjct 671 CLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDL 730
Query 652 DYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFR 711
D+ L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+ R
Sbjct 731 DHSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELR 788
Query 712 RLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT 771
R + +DIG W I+ GI +V+ NA +IA TSD IPRLVY +S+S + T
Sbjct 789 RPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYS-------HNGT 841
Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVI 831
+ G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW V+
Sbjct 842 LHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVL 901
Query 832 AAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884
+A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K
Sbjct 902 SARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 955
>sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7
PE=1 SV=2
Length=859
Score = 958 bits (2476), Expect = 0.0, Method: Composition-based stats.
Identities = 315/841 (37%), Positives = 478/841 (57%), Gaps = 59/841 (7%)
Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125
IDFVLV+E++ R +E K + R+ + NL GL+++ V D+ ++
Sbjct 55 IDFVLVWEEDLRNQENPTKDKTDTHEVWRETFLENLCLAGLKID-QHDVQDEAAAVHYIL 113
Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183
+ APW VLC YAE + +KLPL+ PN N S+ L W + E + E+++
Sbjct 114 LRAPWAVLCYYAEDLRLKLPLQELPNQASNWSAT--LLEWLGIPNILLEHVPDTPPEYYS 171
Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242
F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++
Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKGLFGIDQLLAEGVFS 230
Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA
Sbjct 231 AAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFA 290
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L
Sbjct 291 WLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSS--DSFDMCPLCSD-CSFWLL 347
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419
+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R
Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478
P++ A +N IT E+E P+ +R L S V ++ + I ++ +I+YR
Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSVILYRA 465
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
+ I+ S +D S+T S+++ + I+IL+ +Y +A ++T +E
Sbjct 466 VMAIIVS--------RSDNAFLSAWASRIASLTGSVVNLVFILILSKVYVLLAQVLTRWE 517
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
+ RTQT++E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ G RNEEC G
Sbjct 518 MHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFG-IRNEECPAG 576
Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHR--VSGSEKITPRWEQDYHLQ 656
GCL EL +L +IM GK I NN+QEVL+P + +F R +G+ WE DY L
Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKFSRGKKAGTGTHPAPWEADYELL 636
Query 657 PMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPE 716
P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V E
Sbjct 637 PCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAE 694
Query 717 KAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYI 776
+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G++
Sbjct 695 RAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYSWTHAP---------DLHGFL 745
Query 777 NNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836
N TL+ + P ++ TCRYR FR GH ++ YW ++A +LA
Sbjct 746 NFTLA-----------RAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRLA 789
Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAER 896
F+IV EHV++S+ + +PD+ + + K++RE YL ++ L EN + GV ++
Sbjct 790 FVIVFEHVVFSIGRVLDLLVPDIPESVEIKVKREYYLAKQALAENE--ALLGATGVKDDQ 847
Query 897 M 897
Sbjct 848 P 848
>sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116
GN=Ano7 PE=2 SV=1
Length=860
Score = 956 bits (2470), Expect = 0.0, Method: Composition-based stats.
Identities = 314/842 (37%), Positives = 477/842 (57%), Gaps = 60/842 (7%)
Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125
IDFVLV+E++ R +E + + R+ + NL GL+++ R V D+ ++
Sbjct 55 IDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKID-QRDVQDEAAAVHYIL 113
Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183
+ APW VLC YAE + +KLPL+ PN N S+ L W + E++ E+++
Sbjct 114 LSAPWAVLCYYAEDLRLKLPLQELPNQASNWSAT--LLEWLGIPNILLENVPDTPPEYYS 171
Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242
F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++
Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-QKKGLFGIDQLLAEGVFS 230
Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300
AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA
Sbjct 231 AAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFA 290
Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360
WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L
Sbjct 291 WLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSS--DTFDMCPLCSD-CSFWLL 347
Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419
+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R
Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478
P++ A +N IT E+E P+ +R L S V ++ + I ++ II+YR
Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSIILYRA 465
Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538
+ I+ S ++ S+T S+++ + I+IL+ +Y +A ++T +E
Sbjct 466 VMAIIVS--------KSNNAFLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTRWE 517
Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598
+ RTQT +E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ G RNEEC G
Sbjct 518 MHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFG-VRNEECPAG 576
Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGR---FHRVSGSEKITPRWEQDYHL 655
GCL EL +L +IM GK I NN+QEVL+P + + + +G WE DY L
Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMGANPAPWEADYEL 636
Query 656 QPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVP 715
P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V
Sbjct 637 LPCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVA 694
Query 716 EKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGY 775
E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G+
Sbjct 695 ERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWT---------RAPDLRGF 745
Query 776 INNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKL 835
+N TL+ + P ++ TCRYR FR GH ++ YW ++A +L
Sbjct 746 LNFTLA-----------RAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRL 789
Query 836 AFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAE 895
AF+IV EHV++S F+ +PD+ + + K++RE YL ++ L +N + GV E
Sbjct 790 AFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNE--ALLGATGVKGE 847
Query 896 RM 897
+
Sbjct 848 QP 849
>sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7
PE=1 SV=2
Length=933
Score = 944 bits (2440), Expect = 0.0, Method: Composition-based stats.
Identities = 314/858 (37%), Positives = 477/858 (56%), Gaps = 65/858 (8%)
Query 67 RRIDFVLVYEDESR----KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV 122
R DFVLV+E++ + +++ + + R R+ + NL GL ++ + V D
Sbjct 108 RIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVD-QQDVQDGNTT 166
Query 123 --FVKVHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178
+ + A W VLC YAE + +KLPL+ PN N S+ G L W + E +
Sbjct 167 VHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSA--GLLAWLGIPNVLLEVVPDVP 224
Query 179 QEFFTAPFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVN 237
E+++ F N++ F D +D FF R +I++ IL++ Y + GI++L+
Sbjct 225 PEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKNLLGIHQLLA 283
Query 238 SGIYKAAFPLHDCKFRRQSEDPSCP--NERYLLYREWAHPRSIYKKQPLDLIRKYYGEKI 295
G+ AAFPLHD F+ E P P N+R +L++ WA K QPLD +R+Y+GEK+
Sbjct 284 EGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKV 343
Query 296 GIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLC 355
+YFAWLG+YT LL AAVVG FL G + ++E+C MCP C C
Sbjct 344 ALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGS--KDSFEMCPLCLD-C 400
Query 356 PFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ- 414
PFW L+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + +
Sbjct 401 PFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDT 460
Query 415 EEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGII 474
EE+ RP++ A N IT E+E F + R+ + + + +++ ++ II
Sbjct 461 EERPRPQFAASAPMTAPNPITGEDEP-YFPERSRARRMLAGSVVIVVMVAVVVMCLVSII 519
Query 475 VYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMI 534
+YR + IV S + S+T S+++ + I+IL+ IY +A ++
Sbjct 520 LYRAIMAIVVS--------RSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVL 571
Query 535 TNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEE 594
T +E+ RTQT +E++ T+K+F+FQFVN+YSS YIAFFKG+FVGYPG+ G RNEE
Sbjct 572 TRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFG-VRNEE 630
Query 595 CDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITP------- 647
C GGCL+EL +L +IM GK + NN+QEVL+P + +F S K
Sbjct 631 CAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQG 690
Query 648 RWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLT 707
WE DY L P GLF EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K
Sbjct 691 PWEDDYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFV 748
Query 708 TQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDH 767
++RR V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR Y W+
Sbjct 749 CEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWT--------- 799
Query 768 TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYY 827
++ + G++N TL+ + ++ TCRYR FR GH ++ Y
Sbjct 800 RAHDLRGFLNFTLA-----------RAPSSFAAAHNRTCRYRAFRDDDGH-----YSQTY 843
Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMT 887
W+++A +LAF+IV EHV++SV + +PD+ + + K++RE YL ++ L EN + +
Sbjct 844 WNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEV--LF 901
Query 888 KNMGVIAERMIEAVDNNL 905
G E+ + ++
Sbjct 902 GTNGTKDEQPEGSELSSH 919
>sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9
PE=1 SV=3
Length=782
Score = 727 bits (1876), Expect = 0.0, Method: Composition-based stats.
Identities = 266/849 (31%), Positives = 428/849 (50%), Gaps = 113/849 (13%)
Query 40 ESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAY 99
ES PE + F S + + D+VLV + +++ + ++ ++Q +
Sbjct 5 ESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQR--------DPRQARQQQF 56
Query 100 ESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFG 159
L G ++ + D K VF + A V Y
Sbjct 57 LEELRRKGFHIKV---IRDQKQVFFGIRADNSVFGLY----------------------- 90
Query 160 TLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRV 219
+ L ++ P E AP + R RIV F+
Sbjct 91 ------RTLLLEPEGPAPHAE-LAAPTTIP-------------VTTSLRIRIVNFV---- 126
Query 220 KYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRS 277
V+NN + G L+ G+++A FPLH + R L + WA R
Sbjct 127 ---VMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWRH 169
Query 278 IYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVC 337
++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+C
Sbjct 170 MFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEIC 229
Query 338 HPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWK 397
I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE WK
Sbjct 230 E---AHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWK 286
Query 398 RRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCAS 457
R++A + WD +E++ C + +R T+
Sbjct 287 RQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQ-----------HSYLRSTVILV 335
Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517
I L+I ++VYR+ +FS+ + +++ +T TA +T +++ +
Sbjct 336 LTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVHY 387
Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577
+ I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+
Sbjct 388 VTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRIN 447
Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637
G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ +
Sbjct 448 GHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLR 507
Query 638 R-VSGSEKITPR---WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693
SG P W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLLAL
Sbjct 508 ASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALF 567
Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753
+N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ IPR+
Sbjct 568 SNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRV 627
Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFR 812
VY + +S G+ T ++GY+N++LS+F DF++ + N T CRYRD+R
Sbjct 628 VYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQD---PDGIEGSENVTLCRYRDYR 684
Query 813 YPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872
PP +Y + +W ++A +LAF+I+ EHV +K ++ +PD+ + K+K+ KY
Sbjct 685 NPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKY 740
Query 873 --LTQKLLH 879
L +K+ H
Sbjct 741 QRLREKMWH 749
>sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9
PE=1 SV=1
Length=747
Score = 686 bits (1771), Expect = 0.0, Method: Composition-based stats.
Identities = 229/692 (33%), Positives = 367/692 (53%), Gaps = 82/692 (12%)
Query 198 DRDAFFNPATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQ 255
D +F TR RIV F+ +NN K G LV G+++ F LH +
Sbjct 105 DEQSFNIATTRIRIVSFV--------VNNKLKPGDTFEDLVKDGVFETMFLLHKGEQN-- 154
Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315
L WA R++++ QP+D IR+Y+GEK+ +YF WLG+YT ML+ AAVV
Sbjct 155 ------------LKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVV 202
Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375
G+ FL G+ D+ SKE+C I MCP D + +L+ C +K +FD+
Sbjct 203 GLIVFLSGFALFDSSQISKEICS---ANDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDN 259
Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-------EEQARPEYEARCTH 428
GT++FA+FM +W T+FLE WKR++A W E + E P Y+ +
Sbjct 260 EGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLK--- 316
Query 429 VVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488
+ R + + + ++L F I L+I ++VYR+ +FS+ +
Sbjct 317 ---------DHRHSYLSSTIILILSL------FMICLMIGMAHVLVVYRVLAGALFSSLV 361
Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548
+ + + + +III+I+ + + VA+ + FE T ++ E
Sbjct 362 KQQVTTAVVVTGAVV------------HYIIIVIMTKVNKYVALKLCKFEESGTFSEQER 409
Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608
T+K F+ QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+
Sbjct 410 KFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQM 469
Query 609 TIIMGGKAIWNNIQEVLLP-----WIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL 663
IIMG K +N E L P W + + +S ++ W+++Y++ P+ L
Sbjct 470 AIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPELK-EWQRNYYMNPINTFSL 528
Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723
F E++EM+IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG
Sbjct 529 FDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGT 588
Query 724 WQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS---YTMEGYINNTL 780
W +++ I +LAV+ N M+IAFTS+ IPR+VY + + P + + + Y+N++L
Sbjct 589 WLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYG--PCRTNRTFTDDCLTNYVNHSL 646
Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840
S+F F + S+ N T CRYRD+R +Y + +W ++A +L F+I+
Sbjct 647 SVFYTKHFNDHSRMEGQE---NVTVCRYRDYRN----EHDYNLSEQFWFILAIRLTFVIL 699
Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872
EH +K ++ +PDV ++ K+++ +EKY
Sbjct 700 FEHFALCIKLIAAWFVPDVPQKVKNEVLQEKY 731
>sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO10
PE=1 SV=2
Length=660
Score = 422 bits (1085), Expect = 3e-135, Method: Composition-based stats.
Identities = 149/594 (25%), Positives = 251/594 (42%), Gaps = 121/594 (20%)
Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222
+ + FT + F + D F A I+ L ++
Sbjct 88 LVKECNDNTMRAFTYR-TRQNFKGFDDNNDD-FLTMAECQFIIKHELENLRAKDEKMIPG 145
Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279
G + RL+ SGI FPLHD + ++ ED W + R
Sbjct 146 YPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFAL 192
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QP+D IR Y+GE I +YF +L Y+T L+ AV+G+ +L+ + + D
Sbjct 193 KYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDK---------- 242
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
++FA F +W T+ LE WKR
Sbjct 243 --------------------------------------YVIFASFNLIWSTVILELWKRG 264
Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458
A + Y W T+ ++++ E+ RP + IN IT +EE + + ++ + +RI L S
Sbjct 265 CANMTYRWGTLLMKRKFEEPRPGFHGVLG---INSITGKEEPL-YPSYKRQLRIYLV-SL 319
Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518
F + L + + +I + + V+ + +G++ L SII I
Sbjct 320 PFVCLCLYFSLYVMMIYFDMEVWALGLH----ENSGSEWTSVLL-------YVPSIIYAI 368
Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578
+I I+N +Y A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct 369 VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--- 425
Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----I 633
+ L L ++ I N I E LP+ + +
Sbjct 426 ----------------------MKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRV 463
Query 634 GRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLAL 692
R + ++ +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A+
Sbjct 464 KRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV 523
Query 693 VNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
+NN E+ DA K+ F+R E + +IG WQ + +++++VVTN +I +
Sbjct 524 LNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577
Score = 38.6 bits (88), Expect = 0.34, Method: Composition-based stats.
Identities = 14/53 (26%), Positives = 35/53 (66%), Gaps = 0/53 (0%)
Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890
++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+
Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647
>sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=Ano10
PE=1 SV=1
Length=659
Score = 421 bits (1082), Expect = 7e-135, Method: Composition-based stats.
Identities = 147/594 (25%), Positives = 253/594 (43%), Gaps = 121/594 (20%)
Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222
+ + FT ++ F+ + D F A I+ L ++
Sbjct 88 LVKECTDAAMRAFTYG-TRHNFKGFHDNNND-FLTMAECQFIIKHELENLRARDEKMIPG 145
Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279
G + RL+ SGI FPLHD + ++ ED W + R
Sbjct 146 YPQAKLYPGKSLMRRLLTSGIVTQVFPLHDTEALKKLEDT------------W-YTRFAL 192
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
K QP+D IR Y+GE I +YF +L Y+T L+ A++G+ +L+ + + D
Sbjct 193 KYQPIDSIRSYFGETIALYFGFLEYFTFALIPMAIIGLPYYLFVWEDYDK---------- 242
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
++FA F +W T+ LE WKR
Sbjct 243 --------------------------------------YVIFASFNLIWSTVILEVWKRG 264
Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458
A + Y W T+ ++++ E+ RP + IN +T EE + ++++ + +RI L S
Sbjct 265 CANMTYRWGTLVMKRQFEEPRPGFHGVLG---INSVTGREEPL-YSSYKRQLRIYLV-SL 319
Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518
F + L + + +I + + + + +G++ L SI+ +
Sbjct 320 PFVCLCLYFSLYVMMIYFDMEDWALSLH----EDSGSEWTSLLL-------YVPSIVYAV 368
Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578
+I I+N +Y A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF
Sbjct 369 VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKD--- 425
Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----I 633
+ L L ++ I N + E LLP+ + +
Sbjct 426 ----------------------MKLLRQSLATLLITSQILNQVVESLLPYWLQRKYCARV 463
Query 634 GRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLAL 692
R + SE T +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A+
Sbjct 464 KRKVQALKSEVDTTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV 523
Query 693 VNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
+NN E+ DA K+ F+R E + IG WQ + +++++VVTN +I +
Sbjct 524 LNNFTEVNSDALKMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGMS 577
Score = 38.6 bits (88), Expect = 0.29, Method: Composition-based stats.
Identities = 13/53 (25%), Positives = 34/53 (64%), Gaps = 0/53 (0%)
Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890
++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K + +N+
Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQQKLARLEFESLEALKQQQMKLVAENL 647
>sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano10
PE=2 SV=1
Length=646
Score = 390 bits (1002), Expect = 3e-123, Method: Composition-based stats.
Identities = 149/595 (25%), Positives = 247/595 (42%), Gaps = 123/595 (21%)
Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222
+ + FT + DF D + F A IV L ++
Sbjct 88 LFKEFQDGTMRGFTYA-NRESFKDFEG-DGEGFLGDAECQYIVKHELDTLRAKNEEYIPG 145
Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279
G + RL + G+ FPLH+ + + L W + +
Sbjct 146 YPKYKLYPGKSIVRRLQSKGVLVQYFPLHNKE------------DLKRLSFSW-YKKIKL 192
Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339
QPLD IR Y+GE +G+YF +L Y+T L+ A++G+ +L+ + + D
Sbjct 193 SFQPLDDIRSYFGEGLGLYFGFLEYFTFALIPMALIGIPYYLFDWEDYDK---------- 242
Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399
++FAVF VW T+FLE WKR
Sbjct 243 --------------------------------------YVLFAVFNLVWSTVFLEVWKRC 264
Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458
A L Y W T+ ++ E+ R + +N +T EE I + + + +RI L +
Sbjct 265 SATLAYSWGTLGRKKAFEEPRAGFHGPLG---LNPVTGREEPI-YPSSKRHLRIYLVSVP 320
Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518
F + L ++ + ++ + + + + + +N N + + SII +
Sbjct 321 -FVLLCLYLSFYVMMVYFDMEFWAI--SIYHENPNFATSVLLF---------VPSIIYAV 368
Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578
+I I+N +Y A +T++E R ++ ++N L K+ +F FVN ++S FYIAF V
Sbjct 369 VIEIMNLLYRYAAEFLTDWENHRLESSFQNHLVPKVLVFNFVNCFASLFYIAFVMQDMV- 427
Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL------ 632
L L ++ I N + E LP+ +
Sbjct 428 ------------------------LLRQSLATLLITSQILNQVMEAFLPYWLQRRRNKRV 463
Query 633 IGRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLA 691
R R+ G +++ P EQ M LG F +YLE + FG+V+LF PLA +L
Sbjct 464 YKRMRRLMGDKEL-PLLEQIQLETEMNTYLGTFDDYLEQFLLFGYVSLFSCVHPLAAVLV 522
Query 692 LVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746
++NNI E+ DA+K+ F+R E A +IG WQ + ++I+AVVTN +IA +
Sbjct 523 VLNNITEVYSDAFKMCHVFKRPFSEPAANIGVWQLAFETMSIIAVVTNCALIALS 577
Score = 36.7 bits (83), Expect = 1.1, Method: Composition-based stats.
Identities = 12/43 (28%), Positives = 27/43 (63%), Gaps = 0/43 (0%)
Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHE 880
++ +EHV+ + KF +++ IPDV K + K+ + + + + L +
Sbjct 595 VVAIEHVLLAFKFILAFVIPDVPKHIQVKLSKLDFESLEALKK 637
>sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryza
sativa subsp. japonica OX=39947 GN=Os01g0706700 PE=2 SV=1
Length=665
Score = 376 bits (965), Expect = 1e-117, Method: Composition-based stats.
Identities = 142/673 (21%), Positives = 237/673 (35%), Gaps = 151/673 (22%)
Query 101 SNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGT 160
L GL +E R V + F+K+ AP L A M++K
Sbjct 49 RELEDVGLIVERVRGVPAE---FIKLSAPMGTLGRVAAEMNMK-----KLTYIGMELQFE 100
Query 161 LNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVK 220
+ + + + +E F F + D D + + +
Sbjct 101 WDQVGAFVRQPDGSLFSWRERFAC-FRHLIYSIVNKTDSDITLSFDDKE---FHWTQNES 156
Query 221 YQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYK 280
+ RL + GI K FPLHD R+Q L R WA +
Sbjct 157 L----------LTRLEDEGIVKLVFPLHDEIKRKQ------------LLRSWALKWFDFT 194
Query 281 KQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPD 340
QP+D I Y+G KI IYF++LG YT+ L AV G+
Sbjct 195 WQPIDEIYSYFGTKIAIYFSFLGMYTRWLFFPAVFGL----------------------- 231
Query 341 IGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLV---FAVFMGVWVTLFLEFWK 397
+ +L F S LV F F+ W FL+FWK
Sbjct 232 --------------------------ATQLIDFGSLQWLVLPAFFFFVISWAVFFLQFWK 265
Query 398 RRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCAS 457
R+ + + W + EY+ + + ++ + +G ++
Sbjct 266 RKNSAVLARWGI------NYSFSEYKTMGNELDPLSFSMADDNVQQRKFGAPKEKSIVQR 319
Query 458 AVFFWILLIIA----SVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513
+F +LL I V+ II +L + ++ I T+ ++ LT
Sbjct 320 NEWFGVLLRIRNNAIIVLAIICLQLPFELAYAHLYA--ITKTEALRYVLTA--------- 368
Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573
+ I I KV++ + +E + + +SL K+F F+ Y FY A
Sbjct 369 -VYLAAIQYYTRIGGKVSVTLIKYENNQGEQSSADSLVYKVFGLYFMQSYIGLFYHASLH 427
Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633
++ L L + + N+ E +P++
Sbjct 428 RN-------------------------IMALRQVLIKRLIVSQVLENLIENSIPYLNYSY 462
Query 634 GRFHRV-----------SGSEKITPRWEQDYHLQPMG-------KLGLFYEYLEMIIQFG 675
++ V S +++ R E++Y + GLF ++LE+ +QFG
Sbjct 463 KKYRAVHKKKHEKESPAGKSVRLSTRVEKEYLKPSYTASIGEELEDGLFDDFLELTLQFG 522
Query 676 FVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 735
+ +F +FP A +NN+ EIR DA KL +R P A IGAW I Q + ++A
Sbjct 523 MIMMFACAFPSIFCFAALNNVTEIRADALKLLVMLKRPAPRDAATIGAWLNIFQFLVVMA 582
Query 736 VVTNAMIIAFTSD 748
+ TN +++ D
Sbjct 583 ICTNCLLLVCLYD 595
>sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabidopsis
thaliana OX=3702 GN=At1g73020 PE=1 SV=1
Length=665
Score = 336 bits (862), Expect = 2e-102, Method: Composition-based stats.
Identities = 152/695 (22%), Positives = 261/695 (38%), Gaps = 161/695 (23%)
Query 84 NKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIK 143
K+ E++ + + L G+ ++ + + F+KV AP E+L A +HI+
Sbjct 19 PKRVLEEEEGDCVEVLVTELRKKGMVVDRVVGLAHE---FLKVAAPSEILGNAAAELHIR 75
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFF 203
P + + G+ + + + S FE+ R I
Sbjct 76 KPTRLG-IDLPFEMQGSEAFIRQPDGLLFSW-----------FERFRCYQHLIYG----I 119
Query 204 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263
+ + + R + RL + G+ K FPLHD R++
Sbjct 120 VNSGGHDVTLKLDGREFCWTAGESL---LRRLESEGVIKQMFPLHDELKRKE-------- 168
Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323
L + WA QP+D I Y+G KIG+YF++LG YTQ L+ A++G +
Sbjct 169 ----LLQNWALNWWNCTNQPIDQIYSYFGAKIGVYFSFLGMYTQWLIFPALLGFIVQMVD 224
Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383
+ + + + P F V
Sbjct 225 FGSL----------------QFLALPS------------------------------FFV 238
Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ---------ARPEYEARCTHVVINEI 434
+W LFL+FWKR+ A L W L Q + + + NE
Sbjct 239 GTILWAALFLQFWKRKNAALLARWQINCLVGPSQGYRFLGMEWSSLPFPKELIKNLGNER 298
Query 435 TQEEE---RIPFTAWGKCIRITLCASAVFFWILLIIASVIGI-IVYRLSVFIVFSAKLPK 490
+E+E R + A+ K R + L+I S+I + + + L+ +F
Sbjct 299 AKEKEAYQRYEWFAYRKRFRNDV----------LVIMSIICLQLPFELAYAHIF------ 342
Query 491 NINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSL 550
I +D I+ LT I +II L + KV++ + N E+ + NSL
Sbjct 343 EIITSDIIKYVLTA----------IYLLIIQYLTRLGGKVSVKLINREINESVEYRANSL 392
Query 551 TMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTI 610
K+F F+ Y FY F + L L
Sbjct 393 IYKVFGLYFMQTYIGIFYHVLLHRNF-------------------------MTLRQVLIQ 427
Query 611 IMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSE----------KITPRWEQDY----HLQ 656
+ ++ + + LP++ ++ + + +I R E++Y +
Sbjct 428 RLIISQVFWTLMDGSLPYLKYSYRKYRARTKKKMEDGSSTGKIQIASRVEKEYFKPTYSA 487
Query 657 PMG---KLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRL 713
+G + GLF + LE+ +QFG + +F +FPLA LA V+N++EIR +A KL RR
Sbjct 488 SIGVELEDGLFDDSLELALQFGMIMMFACAFPLAFALAAVSNVMEIRTNALKLLVTLRRP 547
Query 714 VPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSD 748
+P A IGAW I Q + ++++ TN+ ++ D
Sbjct 548 LPRAAATIGAWLNIWQFLVVMSICTNSALLVCLYD 582
>sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=pi030
PE=4 SV=1
Length=668
Score = 312 bits (798), Expect = 3e-93, Method: Composition-based stats.
Identities = 134/658 (20%), Positives = 244/658 (37%), Gaps = 168/658 (26%)
Query 204 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263
+ + R R+VY ++ K + + G N + + FPLH KF +
Sbjct 104 DSSERIRLVYDKITGSKTEDSLGIC-PGENPYAD---IISIFPLHQPKFDIKWS------ 153
Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323
+ W KKQ LD I YG ++ +YFA+ ++ + + + G+
Sbjct 154 ------KYWYQLLLGNKKQ-LDSINAEYGSQVALYFAFADFFKTGVFVLSFWGIL----- 201
Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383
F + +FA+
Sbjct 202 ----------------------------------------------GYYFLRPYSYIFAI 215
Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPF 443
+ +W F++FW+ ++ +L W TV Q ++ E++ + V + R +
Sbjct 216 GVALWGAFFIQFWRVQEHKLTNHWSTVNCQSLAKSMTEFKPQSYRV---DSLLGTARPYY 272
Query 444 TAWGKCIRITLCASAVFF---WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQK 500
W +R T+ +F ILL + ++ I+ LS V+S L
Sbjct 273 PQWEIIVRSTIANVPLFLISGCILLFLIAIAFIVDVTLSE--VYSGPL------------ 318
Query 501 YLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFV 560
++ S+ +++ ++ + IY VA +T E RT+TD++ SL+ KMFL F+
Sbjct 319 ----KSIVSLLPAVVFQVLTLPFTFIYSIVAERLTKLENRRTKTDFQASLSGKMFLQNFM 374
Query 561 NYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL--------LELTTQLTIIM 612
Y++ F I++ G F Y P Y + G L L Q +
Sbjct 375 LSYTALFLISYIYGPFAEY-FVPHYIQNRMSQSFFSVGYIAKSTFKLNPLRLRNQYIYFL 433
Query 613 GGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL--------- 663
+ N I + +P +++ + + H +S + E P + L
Sbjct 434 TNAQVINYITILAVPQLISYVKK-HYMSKPTR-----ELHIQDIPSETVTLKRARSEAEK 487
Query 664 -----FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718
+ +Y + ++ FGF+ +F +PLAP+ +LVN +L IR ++ T ++ VP +
Sbjct 488 IEYDCYNDYKDFVLMFGFLVMFSPIYPLAPIFSLVNCVLYIRSSVYRFTKMVKKPVPCRV 547
Query 719 QDIGAWQPIMQGIAILAVVT----------------NAMIIA----------------FT 746
I W + ++ L +T +M+IA F
Sbjct 548 DSIAPWDQRLSLLSWLGCITMPSICYFYSSTTKPSDKSMVIAAVIGLLSEHLWFLLRMFI 607
Query 747 SDMIP-------------RLVYYWSFSVPPYGDHTSYTMEGY--INNTLSIFKVADFK 789
S + P L+ SFS+PP D + T + + TLSI++ A+ K
Sbjct 608 SSVFPVDKTFFAPAKERQHLLAERSFSIPPVADVPTSTTTAFEEADETLSIYRTAENK 665
>sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8
PE=1 SV=3
Length=1232
Score = 285 bits (730), Expect = 6e-80, Method: Composition-based stats.
Identities = 116/471 (25%), Positives = 195/471 (41%), Gaps = 121/471 (26%)
Query 192 NDFYIVDRDA---FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIY 241
DF + ++ FF R I+ F L ++ + ++NV I L GI
Sbjct 146 EDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGII 205
Query 242 KAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAW 301
+ FP+H+ + + L + W ++ + QPLD I Y+G KI +YFAW
Sbjct 206 QQVFPVHEQRILNR------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAW 251
Query 302 LGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLN 361
LG+YT ++ AV G LY + D + +
Sbjct 252 LGFYTSAMVYPAVFG--SVLYTFTEADQTS----------------------------RD 281
Query 362 ITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQAR 419
++C +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ R
Sbjct 282 VSC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPR 327
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479
P++ I+ IT+ EE + W + + L + + L +A ++ + + L
Sbjct 328 PQFRGVRR---ISPITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLVCVFLLMLG 377
Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539
F + +L ++ G + ++L ++ +++ + Y+K+AI + + E
Sbjct 378 CFQL--QELVLSVKGLPRLARFL---------PKVMLALLVSVSAEGYKKLAIWLNDMEN 426
Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599
R ++ YE L +K+ LFQFVN Y S FYI F+
Sbjct 427 YRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKD------------------------ 462
Query 600 CLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWE 650
+ L L ++ + N++EVL P +L R R G + WE
Sbjct 463 -MERLKEMLATLLITRQFLQNVREVLQP---HLYRRLGR--GELGLRAVWE 507
Score = 124 bits (312), Expect = 1e-27, Method: Composition-based stats.
Identities = 44/103 (43%), Positives = 65/103 (63%), Gaps = 1/103 (1%)
Query 643 EKITPRWEQDYHLQPMGKL-GLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701
E+ +P+ Q M K F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR
Sbjct 723 EEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRS 782
Query 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIA 744
DA+KL T +R ++ + IG WQ +M+ + +LA+V N +I
Sbjct 783 DAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIG 825
Score = 39.4 bits (90), Expect = 0.19, Method: Composition-based stats.
Identities = 12/55 (22%), Positives = 26/55 (47%), Gaps = 0/55 (0%)
Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENH 882
W A + ++V+EH +K+ I AIPD+ ++ + +Y ++ +
Sbjct 836 WLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHE 890
>sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8
PE=1 SV=3
Length=1060
Score = 283 bits (723), Expect = 1e-79, Method: Composition-based stats.
Identities = 110/450 (24%), Positives = 189/450 (42%), Gaps = 116/450 (26%)
Query 192 NDFYIVDRDA---FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIY 241
DF + ++ FF R I+ F L ++ + ++NV I L GI
Sbjct 146 EDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGII 205
Query 242 KAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAW 301
+ FP+H+ + + L + W ++ + QPLD I Y+G KI +YFAW
Sbjct 206 QQVFPVHEQRILNR------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAW 251
Query 302 LGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLN 361
LG+YT ++ AV G LY + D + +
Sbjct 252 LGFYTSAMVYPAVFG--SVLYTFTEADQTS----------------------------RD 281
Query 362 ITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQAR 419
++C +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ R
Sbjct 282 VSC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPR 327
Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479
P++ I+ IT+ EE + W + + L + + L +A +I + + L
Sbjct 328 PQFRGIRR---ISPITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLICVFILMLG 377
Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539
F + +L ++ G + ++L ++ +++ + Y+K+A+ + + E
Sbjct 378 CFQL--QELVLSVKGLPRLVRFL---------PKVMLALLVSVSAEGYKKLAVWLNDMEN 426
Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599
R ++ YE L +K+ LFQFVN Y S FYI F+
Sbjct 427 YRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKD------------------------ 462
Query 600 CLLELTTQLTIIMGGKAIWNNIQEVLLPWI 629
+ L L ++ + + N++EVL P +
Sbjct 463 -MDRLKEMLATLLITRQLLQNVREVLQPHL 491
Score = 125 bits (314), Expect = 5e-28, Method: Composition-based stats.
Identities = 47/116 (41%), Positives = 68/116 (59%), Gaps = 5/116 (4%)
Query 634 GRFHRVS----GSEKITPRWEQDYHLQPMGKL-GLFYEYLEMIIQFGFVTLFVASFPLAP 688
R +R S E+ +P+ Q M K F +Y EM +QFG+V LF ++FPLA
Sbjct 705 KRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAA 764
Query 689 LLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIA 744
L ALVNN++EIR DA+KL T +R + + IG WQ +M+ + +LA+V N +I
Sbjct 765 LCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIG 820
Score = 39.4 bits (90), Expect = 0.21, Method: Composition-based stats.
Identities = 13/52 (25%), Positives = 26/52 (50%), Gaps = 0/52 (0%)
Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLH 879
W A + ++V+EH+ VK+ I AIPD+ ++ + +Y ++
Sbjct 831 WLSPEAAIVSVVVLEHLALLVKYLIHVAIPDIPGWVAEEMAKLEYQRREAFK 882
>sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292
GN=IST2 PE=1 SV=2
Length=946
Score = 87.9 bits (216), Expect = 2e-16, Method: Composition-based stats.
Identities = 77/557 (14%), Positives = 165/557 (30%), Gaps = 143/557 (26%)
Query 235 LVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLL---YREWAHPRSIYKKQPLDLIRKYY 291
L N ++ P HD + ++ +L + + S P
Sbjct 67 LQNLDFIESIIPYHDTELSDDLHKLISISKSKILEAPKQYELYNLSNLTNNP-------- 118
Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351
K +YFA+L Y + L+ + G++ + +
Sbjct 119 --KQSLYFAFLQNYIKWLIPFSFFGLSIRFLSNFTYEFNST------------------- 157
Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411
+++F +W F FW Y+++
Sbjct 158 -----------------------------YSLFAILWTLSFTAFW-------LYKYE--- 178
Query 412 LQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVI 471
+ + + T E + A K + + F + L+ ++
Sbjct 179 ---------PFWSDRLSKYSSFSTIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAI- 228
Query 472 GIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVA 531
++ ++L F + I +L + T ++ +I N
Sbjct 229 -LLSFQLYCFALEIFIKQIYNGPMISILSFLPTILICTFTP-----VLTVIYNK---YFV 279
Query 532 IMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYR 591
+T +E + + + S K F+ F++ Y F + R
Sbjct 280 EPMTKWENHSSVVNAKKSKEAKNFVIIFLSSYVPLLITLFLYLPM------GHLLTAEIR 333
Query 592 NEECDPGGCLLELTT--------------QLTIIMGGKAIWNNIQEVLLPWIMNLIG--- 634
+ + L L T Q + + E +P ++++
Sbjct 334 TKVFNAFSILARLPTHDSDFIIDTKRYEDQFFYFIVINQLIQFSMENFVPSLVSIAQQKI 393
Query 635 --------RFHRVSGSEKITPR----WEQD--YHLQPMG-KLGLFYEYLEMIIQFGFVTL 679
+ G +++ W + Y P G L + ++++QFG++ +
Sbjct 394 NGPNPNFVKAESEIGKAQLSSSDMKIWSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVM 453
Query 680 FVASFPLAPLLALVNNILEIRVDAWKLTTQFRRL--VPEKAQD------------IGAWQ 725
F +PLAP + L+ N++ +VD K + + P D +G W
Sbjct 454 FSTIWPLAPFICLIVNLIVYQVDLRKAV-LYSKPEYFPFPIYDKPSSVSNTQKLTVGLWN 512
Query 726 PIMQGIAILAVVTNAMI 742
++ +IL V A +
Sbjct 513 SVLVMFSILGCVITATL 529
>sp|Q9SZT4|OSC41_ARATH Hyperosmolality-gated Ca2+ permeable channel
4.1 OS=Arabidopsis thaliana OX=3702 GN=OSCA4.1 PE=2 SV=1
Length=817
Score = 46.7 bits (109), Expect = 0.001, Method: Composition-based stats.
Identities = 36/214 (17%), Positives = 69/214 (32%), Gaps = 21/214 (10%)
Query 454 LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513
+ + + IL+ +S + +I + SA N D Q +LT + S
Sbjct 412 VIVNTILLLILVFFSSPLALI------SALVSAGRIFNAEALDSAQYWLTWVQTSGWIGS 465
Query 514 IISFIIIMILNTIYEKVAI-----MITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFY 568
+I + + + + I ++ FE T + + + +KM F VN
Sbjct 466 LIFQFLPNVFIFVSMYIVIPSALSYLSKFERHLTVSGEQRAALLKMVCFFLVNL---IIL 522
Query 569 IAFFKGKFVGYPGDPVYWL----GKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEV 624
A + R EE L + ++
Sbjct 523 KALVESSLESALLKMSRCYLDGEDCKRIEEYMSPSFLSRSCVSALAFLITSTFLGISFDL 582
Query 625 L--LPWIMNLIGRFHRVSGSEKITPRWEQDYHLQ 656
L +PWI I +F + ++ P ++Y L+
Sbjct 583 LAPIPWIKKKIQKFRKNDM-LQLVPEQNEEYALE 615
>sp|A0RPL5|TGT_CAMFF Queuine tRNA-ribosyltransferase OS=Campylobacter
fetus subsp. fetus (strain 82-40) OX=360106 GN=tgt PE=3
SV=1
Length=374
Score = 40.5 bits (93), Expect = 0.056, Method: Composition-based stats.
Identities = 17/89 (19%), Positives = 39/89 (44%), Gaps = 3/89 (3%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202
+P + ++FG +N + D++ I PE + +T F + +N Y F
Sbjct 273 MPTRNARNGTLFTSFGKINIKSAAFIKDDNKIDPECDCYTCSNFSRGYLNHLYKARELTF 332
Query 203 FNPATRSRIVYF--ILSRVKYQVINNVSK 229
F A+ + Y+ ++ +++ ++ K
Sbjct 333 FRLASLHNLHYYLNLVKQMREAIMQGKFK 361
>sp|B9L8E1|TGT_NAUPA Queuine tRNA-ribosyltransferase OS=Nautilia
profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) OX=598659
GN=tgt PE=3 SV=1
Length=378
Score = 39.0 bits (89), Expect = 0.20, Method: Composition-based stats.
Identities = 16/73 (22%), Positives = 30/73 (41%), Gaps = 1/73 (1%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202
+P + + FGTL +DES I P+ +T F + +N + +
Sbjct 273 MPTRNARNGYLFTTFGTLRIKNAKYKLDESPIDPKCNCYTCRNFSRAYLNHLFKAKELTY 332
Query 203 FNPATRSRIVYFI 215
F A+ + Y++
Sbjct 333 FRLASIHNLHYYL 345
>sp|Q5HUF2|TGT_CAMJR Queuine tRNA-ribosyltransferase OS=Campylobacter
jejuni (strain RM1221) OX=195099 GN=tgt PE=3 SV=1
Length=373
Score = 36.3 bits (82), Expect = 1.2, Method: Composition-based stats.
Identities = 20/93 (22%), Positives = 35/93 (38%), Gaps = 2/93 (2%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202
+P + ++FG N D +I P +T F + +N + F
Sbjct 273 MPTRNARNGTFFTSFGKFNIKKAEFINDHEVIDPTCSCYTCRNFSRGYLNHLFKAKELTF 332
Query 203 FNPATRSRIVYFI-LSRVKYQVINNVSKFGINR 234
F A+ + Y++ L+R + I N S R
Sbjct 333 FRLASLHNLHYYLELARKMREAILNNSFTQFKR 365
>sp|Q1EPG7|CSPL1_MUSAC CASP-like protein 1E1 OS=Musa acuminata
OX=4641 GN=MA4_106O17.50 PE=2 SV=1
Length=201
Score = 35.1 bits (79), Expect = 1.7, Method: Composition-based stats.
Identities = 12/89 (13%), Positives = 37/89 (42%), Gaps = 0/89 (0%)
Query 456 ASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASII 515
+S I+L I +++ + + + I+ + +T ++ +A+ +
Sbjct 30 SSTQLPGIILRIVAIVLTFISAVVMGAARQTTTVTGIDAETALLTSITVTVKSTYSAAYV 89
Query 516 SFIIIMILNTIYEKVAIMITNFELPRTQT 544
F++ +L Y V+++++ R +
Sbjct 90 YFVVANVLVFFYSVVSLVLSMVNKARLTS 118
>sp|A7GYD5|TGT_CAMC5 Queuine tRNA-ribosyltransferase OS=Campylobacter
curvus (strain 525.92) OX=360105 GN=tgt PE=3 SV=1
Length=388
Score = 35.5 bits (80), Expect = 2.1, Method: Composition-based stats.
Identities = 14/73 (19%), Positives = 28/73 (38%), Gaps = 1/73 (1%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTA-PFEKNRMNDFYIVDRDAF 202
+P + ++FG + D I PE E +T + + +N + F
Sbjct 285 MPTRNARNGTLFTSFGKIAIKNARFVNDHEPIDPECECYTCRRYSRGYLNHLFRAHELTF 344
Query 203 FNPATRSRIVYFI 215
F A+ + Y++
Sbjct 345 FRLASLHNLHYYL 357
>sp|Q5YCC5|TMC7_CHICK Transmembrane channel-like protein 7 OS=Gallus
gallus OX=9031 GN=Tmc7 PE=2 SV=1
Length=735
Score = 35.1 bits (79), Expect = 3.4, Method: Composition-based stats.
Identities = 78/525 (15%), Positives = 172/525 (33%), Gaps = 107/525 (20%)
Query 284 LDLIRKYYGEKIGIYFAWLGY-----YTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCH 338
+ I +G I YF++L + + +L+ + V + + Y ++ + +K +
Sbjct 143 IHSIEGKFGTGIQSYFSFLRFLVLLNFLMFILMFSFVTLPAVISNYGIFNSSS-TKISPN 201
Query 339 PDIGGKIIMCPQCDRLCPFW-----KLNITCESSKKLCIFDSFGTLVFAVFMGV------ 387
+ P ++ ++ L + +F + T+ A F +
Sbjct 202 NTEPYCTVYTPSGNKGLVYFYTYLKDLLTGTGFLEVTVLFYGYYTIDAAWFSVLRYNLPL 261
Query 388 ------WVTLFLEF-WKRRQAELEYEWDTVELQQEEQA-------------------RPE 421
+ L L F W +++ + V+ + + Q+ R +
Sbjct 262 AYLLTTFAYLALSFVWIIKRSVERFRQHLVDDEDQFQSYCNKVFAGWDFCITDLNAARLK 321
Query 422 YEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVF 481
+ + + N EEER+ + ++ L ++ +I +I+ +V+ Y +
Sbjct 322 HRSLLYELQTN---LEEERLKQKIAERTMKEKLQIYSLRIFINIIVIAVLSGCFYSIYRA 378
Query 482 IVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPR 541
VFS + + + + SI+ I N I ++ + FE
Sbjct 379 TVFS----QENSSVSIRRNVMIANLLVQYLPSIV----ITSANFIAPQIFSFLIRFEDY- 429
Query 542 TQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL 601
+E LT+ + FV V + CD C
Sbjct 430 -SAAFEIRLTL-------------------IRCVFVRLANVGVLLFSLWSQIHCDNDQCK 469
Query 602 -------------LELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR 648
+ ++ ++ I++ + + + ++ + S K+
Sbjct 470 ACGYDYELYPCWESAVGQEMYKLL----IFDFMIIIAMTLFVDFPRKLLVTYCSWKLVQW 525
Query 649 WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASF--PLAPLLALVNNILEIRVDAWKL 706
W + + G+ LE+I +G ++ +F PL P +A + + + L
Sbjct 526 WG-------LQEFGISDNVLEII--YGQTICWIGTFFSPLLPAIATIKYFIIFYIKKISL 576
Query 707 TTQFRRLV--PEKAQDIGAWQPIMQGIA-ILAVVTNAMIIAFTSD 748
R+ P +A + + I ILA V + IA S
Sbjct 577 IHT-RKPASRPIRASSSNFFFLAVLLIGLILAFVPLGVSIALISS 620
>sp|A1VZZ8|TGT_CAMJJ Queuine tRNA-ribosyltransferase OS=Campylobacter
jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
OX=354242 GN=tgt PE=3 SV=1
Length=373
Score = 34.7 bits (78), Expect = 3.5, Method: Composition-based stats.
Identities = 20/93 (22%), Positives = 34/93 (37%), Gaps = 2/93 (2%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202
+P + ++FG N D I P +T F + +N + F
Sbjct 273 MPTRNARNGTFFTSFGKFNIKKAEFINDHEAIDPACSCYTCRNFSRGYLNHLFKAKELTF 332
Query 203 FNPATRSRIVYFI-LSRVKYQVINNVSKFGINR 234
F A+ + Y++ L+R + I N S R
Sbjct 333 FRLASLHNLHYYLELARKMREAILNNSFTQFKR 365
>sp|B6EK65|TGT_ALISL Queuine tRNA-ribosyltransferase OS=Aliivibrio
salmonicida (strain LFI1238) OX=316275 GN=tgt PE=3 SV=1
Length=375
Score = 34.7 bits (78), Expect = 3.5, Method: Composition-based stats.
Identities = 8/57 (14%), Positives = 21/57 (37%), Gaps = 1/57 (2%)
Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDR 199
+P + + G + VD + + PE + +T + K+ ++ +
Sbjct 267 MPTRNARNGHLFVTGGIVKIRNAKHKVDTTPLDPECDCYTCQNYSKSYLHHLDRCNE 323
>sp|Q96NT0|VMA22_HUMAN Vacuolar ATPase assembly protein VMA22
OS=Homo sapiens OX=9606 GN=VMA22 PE=1 SV=1
Length=180
Score = 34.0 bits (76), Expect = 3.6, Method: Composition-based stats.
Identities = 18/58 (31%), Positives = 27/58 (47%), Gaps = 0/58 (0%)
Query 111 EATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVL 168
EA + K+V VHAP EV A + K P K + ++ + LNWF ++
Sbjct 73 EAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILV 130
>sp|Q8VZM5|OSC16_ARATH Hyperosmolality-gated Ca2+ permeable channel
1.6 OS=Arabidopsis thaliana OX=3702 GN=OSCA1.6 PE=2 SV=1
Length=761
Score = 34.7 bits (78), Expect = 4.6, Method: Composition-based stats.
Identities = 25/160 (16%), Positives = 45/160 (28%), Gaps = 10/160 (6%)
Query 406 EWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILL 465
W Q +Q R E T + + IR + A FF
Sbjct 329 RWGAAVCAQTQQTRNPTE-WLTEWAAEPRDIYYDNLALPYVDLKIRRLIVGVAYFF---- 383
Query 466 IIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNT 525
+ I + + I+ L I I ++ L
Sbjct 384 -LTFFFMIPIAFVQSLANIEGIEKAFPFLKPLIEVKLLKSIIQGFLPGIALKIFLLFLPR 442
Query 526 IYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSS 565
I +++ FE + + E + ++FQF+N +
Sbjct 443 ILMQMS----KFEGFVSTSSLERRAATRFYMFQFINVFLG 478
>sp|Q5YCC7|TMC3_CHICK Transmembrane channel-like protein 3 OS=Gallus
gallus OX=9031 GN=Tmc3 PE=2 SV=1
Length=1138
Score = 34.7 bits (78), Expect = 4.7, Method: Composition-based stats.
Identities = 47/305 (15%), Positives = 96/305 (31%), Gaps = 40/305 (13%)
Query 284 LDLIRKYYGEKIGIYFAWLGYYTQM-----LLLAAVVGVACFLYGYLNQDNCTWSKEVCH 338
+ I ++G + YF +L + + ++ A V + L G T SK +
Sbjct 135 IKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFVVLPELLAG--APFGSTVSKTIRQ 192
Query 339 PDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT----LVFAVFMGVWVTLFLE 394
D+ + + G F V M V+ F+
Sbjct 193 EDLKTAQDLDTIWSLGGYLQYSVLFYGYYGSDRKIGKAGYRLPLAYFLVGMAVFAYSFII 252
Query 395 FWKR--RQAEL----------EYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIP 442
K+ + + + + W PE ++N I +
Sbjct 253 LLKKMAKNSRMSLASASDENYTFCWRLFCAWDYLIGNPEAAESKAAAIVNSIREAILEEQ 312
Query 443 FTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYL 502
K + +T+ IIA+++ ++ S++I++ + + L
Sbjct 313 EKKKSKNLAVTISLR--------IIANILVLLSLTGSIYIIYFVVDRSQKLENNKRELTL 364
Query 503 TPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNY 562
+ S+ S+I MI + +E VA + PRT ++ ++ + N
Sbjct 365 WEKNEVSVVVSLI----TMIAPSAFELVAAL--EMYHPRTTLRFQ---LARVLVLYLGNL 415
Query 563 YSSCF 567
YS
Sbjct 416 YSLII 420
>sp|Q62812|MYH9_RAT Myosin-9 OS=Rattus norvegicus OX=10116 GN=Myh9
PE=1 SV=3
Length=1961
Score = 34.7 bits (78), Expect = 5.1, Method: Composition-based stats.
Identities = 20/93 (22%), Positives = 33/93 (35%), Gaps = 13/93 (14%)
Query 64 DGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVF 123
+ R D +L E E K K E + + + +S L+ LQL+ +
Sbjct 839 NSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTE---- 894
Query 124 VKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSS 156
LC AE + +L K +L+
Sbjct 895 ---------LCAEAEELRARLTAKKQELEEICH 918
>sp|Q9ULH1|ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and
PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1
PE=1 SV=4
Length=1129
Score = 34.7 bits (78), Expect = 5.3, Method: Composition-based stats.
Identities = 12/63 (19%), Positives = 25/63 (40%), Gaps = 0/63 (0%)
Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120
FF DG + D + Y ++ + + + +K+ +LI LQL+ +
Sbjct 250 FFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQ 309
Query 121 LVF 123
+
Sbjct 310 GGY 312
>sp|Q8VDD5|MYH9_MOUSE Myosin-9 OS=Mus musculus OX=10090 GN=Myh9
PE=1 SV=4
Length=1960
Score = 34.3 bits (77), Expect = 6.4, Method: Composition-based stats.
Identities = 20/93 (22%), Positives = 33/93 (35%), Gaps = 13/93 (14%)
Query 64 DGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVF 123
+ R D +L E E K K E + + + +S L+ LQL+ +
Sbjct 839 NSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETE---- 894
Query 124 VKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSS 156
LC AE + +L K +L+
Sbjct 895 ---------LCAEAEELRARLTAKKQELEEICH 918
Lambda K H a alpha
0.318 0.127 0.347 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0388 0.140 1.90 42.6 43.6
Effective search space used: 105757600374
Database: uniprot_sprot.fasta
Posted date: Jun 30, 2025 8:32 PM
Number of letters in database: 207,922,125
Number of sequences in database: 573,661
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40