PSIBLAST 2.11.0+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Stephen F. Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: uniprot_sprot.fasta 571,864 sequences; 207,016,062 total letters Results from round 1 Query= sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 PE=1 SV=2 Length=910 Score E Sequences producing significant alignments: (Bits) Value sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 ... 1899 0.0 sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6... 1668 0.0 sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 ... 887 0.0 sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5... 851 0.0 sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4... 711 0.0 sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE... 711 0.0 sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 ... 707 0.0 sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 ... 668 0.0 sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3... 665 0.0 sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1... 603 0.0 sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 ... 594 0.0 sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2... 556 0.0 sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 ... 555 0.0 sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7... 533 2e-175 sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=A... 530 3e-174 sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 ... 525 2e-171 sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 ... 429 2e-136 sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9... 384 1e-119 sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO... 171 3e-43 sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=An... 169 2e-42 sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano1... 164 6e-41 sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 ... 119 7e-26 sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8... 118 8e-26 sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryz... 115 4e-25 sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabido... 102 7e-21 sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosa... 100 2e-20 sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Sacc... 41.2 0.052 sp|Q2S8D3|F16PA_HAHCH Fructose-1,6-bisphosphatase class 1 OS=Hahe... 35.4 2.2 sp|Q9VNS0|MAEL_DROME Protein maelstrom OS=Drosophila melanogaster... 34.7 4.5 sp|Q12202|OSW2_YEAST Outer spore wall protein 2 OS=Saccharomyces ... 34.3 5.8 sp|Q1KXV4|NU3C_HELAN NAD(P)H-quinone oxidoreductase subunit 3, ch... 32.3 7.4 sp|B2LMJ8|NU3C_GUIAB NAD(P)H-quinone oxidoreductase subunit 3, ch... 32.3 7.4 sp|Q6R799|Y120_OSHVF Uncharacterized protein ORF120 OS=Ostreid he... 30.8 8.6 >sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 PE=1 SV=2 Length=910 Score = 1899 bits (4919), Expect = 0.0, Method: Compositional matrix adjust. Identities = 910/910 (100%), Positives = 910/910 (100%), Gaps = 0/910 (0%) Query 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL Sbjct 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60 Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK Sbjct 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE Sbjct 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180 Query 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI Sbjct 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240 Query 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA Sbjct 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL Sbjct 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP Sbjct 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420 Query 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV Sbjct 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480 Query 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP Sbjct 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540 Query 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC Sbjct 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600 Query 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK Sbjct 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660 Query 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD Sbjct 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720 Query 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL Sbjct 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780 Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV Sbjct 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA Sbjct 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900 Query 901 VDNNLRPKSE 910 VDNNLRPKSE Sbjct 901 VDNNLRPKSE 910 >sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6 PE=1 SV=1 Length=911 Score = 1668 bits (4319), Expect = 0.0, Method: Compositional matrix adjust. Identities = 821/912 (90%), Positives = 863/912 (95%), Gaps = 3/912 (0%) Query 1 MKKMSRNVLLQMEEEEDDDDGD-IVLENLGQTIV-PDLGSLESQHDFRTPEFEEFNGKPD 58 M+ M+R VLL ME EEDDD+ IVLEN QTIV P GSLE+Q DFRTPEFEEFNGKPD Sbjct 1 MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPD 60 Query 59 SLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLD 118 SLFF DGQRRIDF+LVYEDES+KE NKKGTNEKQ+RKRQAYESNLICHGLQLEATRSV D Sbjct 61 SLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSD 120 Query 119 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK RS FG LNWFTKVL V+ES+IKPE Sbjct 121 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRS-PFGNLNWFTKVLRVNESVIKPE 179 Query 179 QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNS 238 QEFFTAPFEK+RMNDFYI+DRD+FFNPATRSRIVYFILSRVKYQV+NNV+KFGINRLV+S Sbjct 180 QEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSS 239 Query 239 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 298 GIYKAAFPLHDC+F +SED SCP+ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY Sbjct 240 GIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 299 Query 299 FAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFW 358 FAWLGYYTQMLLLAAVVGVACFLYGYL+QDNCTWSKEVC PDIGG+I+MCPQCDRLCPFW Sbjct 300 FAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFW 359 Query 359 KLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 418 +LNITCESSKKLCIFDSFGTL+FAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA Sbjct 360 RLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 419 Query 419 RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478 RPEYEA+C HVVINEITQEEERIPFT GKCIR+TLCASAVFFWILLIIASVIGIIVYRL Sbjct 420 RPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRL 479 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 SVFIVFS LPKN NGTDPIQKYLTPQ ATSITASIISFIIIMILNTIYEKVAIMITNFE Sbjct 480 SVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFE 539 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVY LGKYR+EECDPG Sbjct 540 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPG 599 Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPM 658 GCLLELTTQLTIIMGGKAIWNNIQEVLLPW+MNLIGR+ RVSGSEKITPRWEQDYHLQPM Sbjct 600 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPM 659 Query 659 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR+VPEKA Sbjct 660 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKA 719 Query 719 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINN 778 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS+PPYGDHT YTM+GYINN Sbjct 720 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINN 779 Query 779 TLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFI 838 TLS+F + DFKN K NPY LGN+T CRYRDFR PPGHPQEYKHNIYYWHVIAAKLAFI Sbjct 780 TLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFI 839 Query 839 IVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMI 898 IVMEH+IYSVKFFISYAIPDVSK TKSKI+REKYLTQKLLHE+HLKD+TKNMG+IAER+ Sbjct 840 IVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIG 899 Query 899 EAVDNNLRPKSE 910 VDN++RPK E Sbjct 900 GTVDNSVRPKLE 911 >sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 PE=1 SV=1 Length=913 Score = 887 bits (2293), Expect = 0.0, Method: Compositional matrix adjust. Identities = 435/855 (51%), Positives = 597/855 (70%), Gaps = 37/855 (4%) Query 50 FEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQ 109 F++ DS+FF DG R+IDFVL Y D+ +K+ K +R+ +E+NL GL+ Sbjct 61 FQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDAELKA------ERRKEFETNLRKTGLE 114 Query 110 LEA--TRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKV 167 LE R D + FVK+HAPWEVL TYAE++ IK+P+K +D+ +++ Sbjct 115 LEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHT--PISYVLGP 172 Query 168 LSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNV 227 + + S+ P E+FTA F ++R F I D+ FF ++R+RIVY+ILSR + + + Sbjct 173 VRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGIEDGK 232 Query 228 SKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLI 287 +FGI RL+NS Y +A+PLHD ++ + SE P+ NERY L++ WA YK+QPLDLI Sbjct 233 KRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQPLDLI 292 Query 288 RKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIM 347 + YYGEKIGIYF +LG+YT+ML AAVVG+ACF+YG L+ ++ T S E+C P+IGG++IM Sbjct 293 KNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGGQMIM 352 Query 348 CPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEW 407 CP CD++C +W+LN TC +SK +FD+ T+ FA+FMG+WVTLFLEFWK+RQA LEYEW Sbjct 353 CPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARLEYEW 412 Query 408 DTVELQQEEQA---RPEYEARCTHVVINEITQEEE-------RIPFTAWGKCIRITLCAS 457 D V+ ++E+Q RPE+EA C H +N +T+E E RIP+ L + Sbjct 413 DLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEPYMPLYTRIPW--------YFLSGA 464 Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517 V W+ L++ S++ +IVYRLSVF F++ + + + ++ +LTPQ TS+T S ++F Sbjct 465 TVTLWMSLVVTSMVAVIVYRLSVFATFASFMESDAS-LKQVKSFLTPQITTSLTGSCLNF 523 Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577 I+I+ILN YEK++ IT E+PRT +YE+SLT+KMFLFQFVN+YSSCFY+AFFKGKFV Sbjct 524 IVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFV 583 Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637 GYPG Y ++R+EECDPGGCL+ELTTQLTIIM GK I+ NI+E + P +N R Sbjct 584 GYPGKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRK 643 Query 638 RVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNIL 697 + SEK+ RWEQD+ L+ G LGLFYEYLE + QFGFVTLFVASFPLAPLLAL+NNI+ Sbjct 644 ARTNSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIV 703 Query 698 EIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYW 757 EIRVDAWKLTTQ+RR V KA IG WQ I+ G+A+L+V TNA I+AFTSD+IPRLVYY+ Sbjct 704 EIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYY 763 Query 758 SFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGH 817 ++S + + M GY+NN+LS+F +ADF N + + D TCRYRD+RYPP Sbjct 764 AYST-----NATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDF---ITCRYRDYRYPPDD 815 Query 818 PQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKL 877 +Y HN+ +WHV+AAK+ FIIVMEHV++ VKF +++ IPDV K +I+REK +T K+ Sbjct 816 ENKYFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKI 875 Query 878 LHENHLKDMTKNMGV 892 LH+ L + +N+G+ Sbjct 876 LHDFELNKLKENLGI 890 >sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5 PE=2 SV=1 Length=904 Score = 851 bits (2198), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/905 (49%), Positives = 600/905 (66%), Gaps = 53/905 (6%) Query 35 DLGSLESQ----HDFRTPEFEEFN-------------GKPDSLFFNDGQRRIDFVLVYED 77 +LGS E+ D ++P + FN DS+FF DG R+IDFVL Y + Sbjct 21 NLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYVE 80 Query 78 ESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV--LDDKLVFVKVHAPWEVLCT 135 + +K+ E + +R+ +E NL GL LE + D K FVK+HAPWEVL T Sbjct 81 DLKKD------GELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLVT 134 Query 136 YAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFY 195 YAE++ IK+P+K +D+ + L++ + + S+ P E+FTA F ++R F Sbjct 135 YAEVLGIKMPIKLSDIPR--PKYPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELFL 192 Query 196 IVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQ 255 I D FF +TR+RIVY+ILSR + V K GI RL+NS Y +A+PLHD ++ + Sbjct 193 IEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKP 252 Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315 S+ + PNERY L + WA YK+QP LIR Y+GEKIGIYF +LGYYT+MLL AA+V Sbjct 253 SKT-TRPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALV 311 Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375 G+ACF+YG L+ +N S E+C PDIGG++IMCP CD +C +W+LN TC SK +FD+ Sbjct 312 GLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDN 371 Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA---RPEYEARCTHVVIN 432 T+ FA+FMG+WVTLFLEFWK+RQA LEYEWD V+ ++E+Q RPE+EA C H +N Sbjct 372 ESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKMN 431 Query 433 EITQE-EERIPFTAWGKCIRIT---LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488 +T+E E +P C RI + + V F + L+++S++ I++YRLSVF F++ + Sbjct 432 PVTKEMEPHMPL-----CHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFM 486 Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548 ++ + TPQ AT+++ S ++ I+I+ILN YEK++ IT E+PRT +YE+ Sbjct 487 ESEAT-LQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYES 545 Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608 SLT+KMFLFQFVNYYSSCFY+AFFKGKFVGYPG Y +R+EEC P GCL+ELTTQL Sbjct 546 SLTLKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQL 605 Query 609 TIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYL 668 TIIM GK I+ NI E P I N R + SEK+ RWEQD+ LQ G GLFYEYL Sbjct 606 TIIMIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYL 665 Query 669 EMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIM 728 E +IQFGF TLFVASFPLAPL AL+NNI+ IRVDAWKLTTQ+RR V KA IG WQ I+ Sbjct 666 ETVIQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDIL 725 Query 729 QGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADF 788 G+AI++V TNA I++FTSD+IPRLVY++++S +++ + GY+NN+LS+F +ADF Sbjct 726 FGMAIVSVATNAFIVSFTSDIIPRLVYFYAYST-----NSTEPLSGYVNNSLSVFLIADF 780 Query 789 KNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSV 848 N + D TCRYRD+RYPP H +Y HN+ +WHV+AAK+ FIIVMEHV++ Sbjct 781 PNHTVPMEKKDF---VTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLF 837 Query 849 KFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM----GVIAERMIEAVDNN 904 KF +++ IPDV K KI+REK +T K++H+ L + +N+ G I + ++ DN+ Sbjct 838 KFLLAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNS 897 Query 905 LRPKS 909 L+ K+ Sbjct 898 LKAKT 902 >sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4 PE=1 SV=2 Length=955 Score = 711 bits (1835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 408/925 (44%), Positives = 588/925 (64%), Gaps = 74/925 (8%) Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54 +++M+++V + +E E DDD + NL T D LE+ + E N Sbjct 51 IQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SEDTSRLEAGGE----TVRERN 105 Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114 K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E Sbjct 106 -KSNGLYFRDGKCRIDYILVYRKSN-----------PQTEKREVFERNIRAEGLQMEKES 153 Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164 S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213 Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221 K + +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKY 273 Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279 + N K G+NRL+ +G Y+AAFPLH+ +R ++ + N R+LLY WA Y Sbjct 274 EEGKN--KIGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWGVWY 331 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+C SKEVC Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVCQ- 390 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR Sbjct 391 --ATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448 Query 400 QAELEYEWDTVE-LQQEEQARPEYEARCTHV-VINEITQEEERIPFTAW-GKCIRITLCA 456 +A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E P+ A+ KC R+ + A Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPE--PYQAFTDKCSRLIVSA 506 Query 457 SAVFFWILLIIASVIGIIVYRL---SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513 S +FF I ++IA+V GI++YR+ S F F L +N Q AT+ TA Sbjct 507 SGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRN-----------NSQVATTGTAV 555 Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573 I+F IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF Sbjct 556 CINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFL 615 Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633 G+F G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N Sbjct 616 GRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWW 675 Query 634 GR--FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPL 689 R + G+E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPL Sbjct 676 TRRKVRQEHGTERKINFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPL 735 Query 690 LALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDM 749 LAL+NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD Sbjct 736 LALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDF 795 Query 750 IPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT--- 805 IPRLVY + + G+ M GY+N +LS+F+++DF+N+S+ P SD + Sbjct 796 IPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPL 853 Query 806 --CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRT 863 CRYRD+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K Sbjct 854 KYCRYRDYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDL 913 Query 864 KSKIQREKYLTQKLLHENHLKDMTK 888 + +++REKYL Q++++E L+ + K Sbjct 914 RDRMRREKYLIQEMMYEAELERLQK 938 >sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE=2 SV=1 Length=920 Score = 711 bits (1835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 407/902 (45%), Positives = 578/902 (64%), Gaps = 68/902 (8%) Query 18 DDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYED 77 DDD + NL T D LE+ + PE + NG L+F DG+ RID++LVY Sbjct 39 DDDSLLHPGNLTST-SDDASRLEAGGE-TVPEKNKLNG----LYFRDGKCRIDYILVYRK 92 Query 78 ESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYA 137 + Q KR+ +E N+ GLQ+E S+++ ++FVK+HAPWEVL YA Sbjct 93 SN-----------PQMEKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYA 141 Query 138 EIMHIKLPLK------PNDLKNRSSAFGTLNWF-----TKVLSVDESIIK--PEQEFFTA 184 E M++++P + P K S ++ F K + +D+ + E + +TA Sbjct 142 EQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTA 201 Query 185 PFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAA 244 PF + R++ F I ++D FFN ATRSRIV+ IL R+KY+ N K G+NRL+ +G Y+AA Sbjct 202 PFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYEEGKN--KIGLNRLLTNGSYEAA 259 Query 245 FPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWL 302 FPLH+ +R ++ N R+LLY WA YK QPLDL+R+Y+GEKIG+YFAWL Sbjct 260 FPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWL 319 Query 303 GYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNI 362 G+YT ML AA +G+ FLYG + D+C SKEVC IIMCP CD+ CPF +L+ Sbjct 320 GWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVCQ---ATDIIMCPVCDKYCPFMRLSD 376 Query 363 TCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE-LQQEEQARPE 421 +C +K +FD+ T+ FAVFM VW T+FLEFWKRR+A + Y+WD ++ ++EE+ RP+ Sbjct 377 SCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEIRPQ 436 Query 422 YEARCTHV-VINEITQEEERIPFTAWG-KCIRITLCASAVFFWILLIIASVIGIIVYRL- 478 +EA+ + +N I+ + E P+ A+ KC R+ + AS +FF I ++IA+V GI++YR+ Sbjct 437 FEAKYSKKERMNPISGKPE--PYQAFADKCSRLIVSASGIFFMICVVIAAVFGIVIYRVV 494 Query 479 --SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITN 536 S F F L +N Q AT+ TA I+F IIM+LN +YEKVA+++TN Sbjct 495 TVSTFAAFKWALIRN-----------NSQVATTGTAVCINFCIIMLLNVLYEKVALLLTN 543 Query 537 FELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECD 596 E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F G+PG + + ++R EEC Sbjct 544 LEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECH 603 Query 597 PGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGR--FHRVSGSE-KIT-PRWEQD 652 P GCL++L Q+ IIM K WNN E+ P I N R + G E KI+ P+WE+D Sbjct 604 PSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQEHGPERKISFPQWEKD 663 Query 653 YHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712 Y+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+NNI+EIR+DA+K TQ+RR Sbjct 664 YNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRR 723 Query 713 LVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS-VPPYGDHTSYT 771 + +A+DIG W I++GI IL+V+TNA +IA TSD IPRLVY + + G+ Sbjct 724 PLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKC 783 Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT-----CRYRDFRYPPGHPQEYKHNIY 826 M GY+N +LS+F+++DF+N+S+ P SD + CRYRD+R PP Y + + Sbjct 784 MVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQ 841 Query 827 YWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDM 886 +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++REKYL Q++++E L+ + Sbjct 842 FWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERL 901 Query 887 TK 888 K Sbjct 902 QK 903 >sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 PE=1 SV=1 Length=955 Score = 707 bits (1824), Expect = 0.0, Method: Compositional matrix adjust. Identities = 409/925 (44%), Positives = 588/925 (64%), Gaps = 74/925 (8%) Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54 +++M+++V + +E E DDD + NL T D LE+ + PE + N Sbjct 51 IQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTST-SDDASRLEAGGE-TVPERNKSN 108 Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114 G L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E Sbjct 109 G----LYFRDGKCRIDYILVYRKSN-----------PQTEKREVFERNIRAEGLQMEKES 153 Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164 S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213 Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221 K + +D+ + E + +TAPF + R++ F I +++ FFN ATRSRIV+ IL R+KY Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKY 273 Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279 + N K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA Y Sbjct 274 EEGKN--KIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWY 331 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+ SKEVC Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVCQ- 390 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR Sbjct 391 --ATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448 Query 400 QAELEYEWDTVE-LQQEEQARPEYEARCTHV-VINEITQEEERIPFTAW-GKCIRITLCA 456 +A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E P+ A+ KC R+ + A Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPE--PYQAFTDKCSRLIVSA 506 Query 457 SAVFFWILLIIASVIGIIVYRL---SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513 S +FF I ++IA+V GI++YR+ S F F L +N Q AT+ TA Sbjct 507 SGIFFMICVVIAAVFGIVIYRVVTVSTFAAFKWALIRN-----------NSQVATTGTAV 555 Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573 I+F IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF Sbjct 556 CINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFL 615 Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633 G+F G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N Sbjct 616 GRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWW 675 Query 634 GR--FHRVSGSE-KIT-PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPL 689 R + G E KI+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPL Sbjct 676 TRRKVRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPL 735 Query 690 LALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDM 749 LAL+NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD Sbjct 736 LALLNNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDF 795 Query 750 IPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT--- 805 IPRLVY + + G+ M GY+N +LS+F+++DF+N+S+ P SD + Sbjct 796 IPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSE--PESDGSEFSGTPL 853 Query 806 --CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRT 863 CRYRD+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K Sbjct 854 KYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDL 913 Query 864 KSKIQREKYLTQKLLHENHLKDMTK 888 + +++REKYL Q++++E L+ + K Sbjct 914 RDRMRREKYLIQEMMYEAELERLQK 938 >sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 PE=1 SV=2 Length=981 Score = 668 bits (1724), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/852 (44%), Positives = 537/852 (63%), Gaps = 64/852 (8%) Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 F DG++RID++LVY ++TN Q KR +E NL GL LE ++ Sbjct 156 LFKDGKKRIDYILVY-----RKTNI------QYDKRNTFEKNLRAEGLMLEKEPAIASPD 204 Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPND--LKNRSSAFGTL--------NWFTKVLSV 170 ++F+K+H PW+ LC YAE ++I++P + RS + G + NW + V Sbjct 205 IMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMV 264 Query 171 DESIIKP---EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNV 227 + P E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+ N + Sbjct 265 LDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE--NGI 322 Query 228 SKFGINRLVNSGIYKAAFPLHDCKFRR----QSEDPSCPNERYLLYREWAHPRSIYKKQP 283 SK GI +L+N+G Y AAFP H+ ++ ++ P N R+LLY WA YK QP Sbjct 323 SKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQ--NNRHLLYERWARWGMWYKHQP 380 Query 284 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGG 343 LDLIR Y+GEKIG+YFAWLG+YT ML+ AA+VG+ F YG +N S+E+C Sbjct 381 LDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICK---AT 437 Query 344 KIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAEL 403 ++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++ L Sbjct 438 EVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSIL 497 Query 404 EYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAVFF 461 Y WD +E ++EE+ RP++EA+ + ++N IT + E ++ K R+ + S +FF Sbjct 498 TYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSS-DKVTRLLVSVSGIFF 556 Query 462 WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIM 521 I L+I +V G++VYRL V F A N I++Y Q ATS A I+FIIIM Sbjct 557 MISLVITAVFGVVVYRLVVMEQF-ASFKWNF-----IKQYW--QFATSAAAVCINFIIIM 608 Query 522 ILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPG 581 +LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+PG Sbjct 609 LLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPG 668 Query 582 DPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSG 641 ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R H++ Sbjct 669 KYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSR-HKIKR 727 Query 642 S--EKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEI 699 + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+EI Sbjct 728 GIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEI 787 Query 700 RVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSF 759 R+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY + + Sbjct 788 RLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKY 847 Query 760 SVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPG 816 P +H + ++GY+NN+LS F +++ +G CRYRD+R PP Sbjct 848 G--PCANHVEPSENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPPW 895 Query 817 HPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQK 876 + Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPDV K +I+REKYL Q+ Sbjct 896 SSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQE 955 Query 877 LLHENHLKDMTK 888 +++E L+ + + Sbjct 956 MMYEAELEHLQQ 967 >sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 Length=981 Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust. Identities = 375/855 (44%), Positives = 541/855 (63%), Gaps = 64/855 (7%) Query 58 DSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVL 117 L F DG++RID++LVY ++TN Q KR +E NL GL LE ++ Sbjct 153 SGLLFKDGKKRIDYILVY-----RKTNI------QYDKRNTFEKNLRAEGLMLEKEPAIA 201 Query 118 DDKLVFVKVHAPWEVLCTYAEIMHIKLPLKP----NDLKNRSSAFGTLNWFTKV------ 167 + ++F+K+H PW+ LC YAE ++I++P + D KN+S + N+F ++ Sbjct 202 NPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKS-RVQNYFKRIKKWMSQ 260 Query 168 --LSVDESIIKP--EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223 + +D+S E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+ Sbjct 261 NPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319 Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR----QSEDPSCPNERYLLYREWAHPRSIY 279 N +SK GI +L+ +G Y AAFP H+ ++ ++ P N R+LLY WA Y Sbjct 320 -NGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQ--NNRHLLYERWARWGMWY 376 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AAVVG+ F YG + + S+E+C Sbjct 377 KHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICK- 435 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 ++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR Sbjct 436 --ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRR 493 Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457 ++ L Y WD +E ++EE+ RP++EA+ + VIN IT + E ++ K R+ + S Sbjct 494 RSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSS-DKVTRLLVSVS 552 Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517 +FF I L+I +V ++VYRL V F A N ++++ Q ATS A I+F Sbjct 553 GIFFMISLVITAVFAVVVYRLVVMEQF-ASFKWNF-----VKQHW--QFATSGAAVCINF 604 Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577 IIIM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FV Sbjct 605 IIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFV 664 Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637 G+PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R Sbjct 665 GHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHK 724 Query 638 RVSGSEKIT-PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNI 696 G + + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI Sbjct 725 IKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNI 784 Query 697 LEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYY 756 +EIR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY Sbjct 785 IEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYE 844 Query 757 WSFSVPPYGDHTSYT---MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRY 813 + + P +H ++GY+NN+LS F +++ +G CRYRD+R Sbjct 845 YKYG--PCANHVKQNENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRG 892 Query 814 PPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYL 873 PP + Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPD+ K + +I+REKYL Sbjct 893 PPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYL 952 Query 874 TQKLLHENHLKDMTK 888 Q++++E L+ + + Sbjct 953 VQEMMYEAELEHLQQ 967 >sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1 PE=1 SV=2 Length=960 Score = 603 bits (1554), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/946 (38%), Positives = 522/946 (55%), Gaps = 99/946 (10%) Query 33 VPDLGSLESQHDFRTPEFEEFNGKPDS-----LFFNDGQRRIDFVLVYE----------- 76 + DLG L S+ + PD+ L+F DG+R++D++LVY Sbjct 25 IEDLGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLA 80 Query 77 ----------------------------DESRKETNKKGTNEKQRRKRQAYESNLICHGL 108 D E + +R +R+ YE NL+ GL Sbjct 81 RRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRFRREEYEGNLLEAGL 140 Query 109 QLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVL 168 +LE + FVK+HAPW VLC AE + +K+P K + + S G L VL Sbjct 141 ELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTK--KVYHISETRGLLKTINSVL 198 Query 169 SVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVK 220 I+P+ + + PF + + + F + DRD+FF+ TRS IVY IL R Sbjct 199 QKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIVYEILKRT- 257 Query 221 YQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYK 280 GI L+ +G+Y AA+PLHD + + + N+R LLY EWA YK Sbjct 258 -TCTKAKYSMGITSLLANGVYSAAYPLHDGDYEGDNVEF---NDRKLLYEEWASYGVFYK 313 Query 281 KQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPD 340 QP+DL+RKY+GEK+G+YFAWLG YTQML+ A++VGV FLYG D S E+C D Sbjct 314 YQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMC--D 371 Query 341 IGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQ 400 I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM +W F+E WKR+Q Sbjct 372 QRYNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQ 431 Query 401 AELEYEWDTVELQQEEQA-----RPEYEARCTHVVINEIT--QEEERIPFTAWGKCIRIT 453 L Y WD ++EE+A R EYEAR + + + +E +++ T + Sbjct 432 MRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDRFPAYF 491 Query 454 LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513 ++ F I + A V+G+I+YR+S + +N + ++ + + + TA Sbjct 492 TNLVSIIFMIAVTFAIVLGVIIYRISTAAALA------MNSSPSVRSNI--RVTVTATAV 543 Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573 II+ ++I++L+ +Y +A +T E+P+T+ +E LT K FL +FVN Y+ FY+AFFK Sbjct 544 IINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFK 603 Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNL 632 G+FVG PGD VY +R EEC PGGCL+EL QL+IIM GK I NN+ E+ +P + Sbjct 604 GRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKF 663 Query 633 IG--RFHRVSGSE-----KITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFP 685 I + R S S+ K R+E D++L+P GL EY+EMIIQFGFVTLFVASFP Sbjct 664 IRYLKLRRQSPSDREEYVKRKQRYEVDFNLEPFA--GLTPEYMEMIIQFGFVTLFVASFP 721 Query 686 LAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAF 745 LAPL AL+NNI+EIR+DA K T+ RR V +A+DIG W I++G+ LAV+ NA +I+F Sbjct 722 LAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISF 781 Query 746 TSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT 805 TSD IPRLVY + +S + TM G++N+TLS F V+DF+N + N DLG Sbjct 782 TSDFIPRLVYLYMYS-------QNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQ 834 Query 806 -CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTK 864 CRY+D+R PP +Y + +W V+AA+LAF+IV ++++ + F+ + IPD+ K Sbjct 835 ICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDIS 894 Query 865 SKIQREKYLTQKL-LHENHLKDMTKNMGVIAERMIEAVDNNLRPKS 909 +I +EK L +L + E K + + E+ + NN P + Sbjct 895 QQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTT 940 >sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 PE=1 SV=1 Length=986 Score = 594 bits (1532), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/942 (37%), Positives = 519/942 (55%), Gaps = 128/942 (14%) Query 33 VPDLGSLESQHDFRTPEFEEFNGKPDS-----LFFNDGQRRIDFVLVYEDESRKETNK-- 85 + D+G L S+ + PD+ L+F DG+R++D++LVY R N+ Sbjct 25 IEDIGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGRRKVDYILVYH-HKRPSGNRTL 79 Query 86 ------------------------KGTN--------------EKQRRKRQAYESNLICHG 107 KG + + +R +R+ YE NL+ G Sbjct 80 VRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAG 139 Query 108 LQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKV 167 L+LE + FVK+HAPW VLC AE + +K+P K + + + G L V Sbjct 140 LELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTK--KMYHINETRGLLKKINSV 197 Query 168 LSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRV 219 L I+P+ + + PF + + + F + D+D+FF+ TRS IVY IL R Sbjct 198 LQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRT 257 Query 220 KYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279 GI L+ +G+Y AA+PLHD + ++ + N+R LLY EWA Y Sbjct 258 --TCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEF---NDRKLLYEEWARYGVFY 312 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QP+DL+RKY+GEKIG+YFAWLG YTQML+ A++VG+ FLYG D S E+C Sbjct 313 KYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMC-- 370 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM +W F+E WKR+ Sbjct 371 DQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRK 430 Query 400 QAELEYEWDTVELQQEEQA-----RPEYEARCTHVVINEITQEEER---IP---FTAWGK 448 Q L Y WD ++EE+A R EYEAR + + ++ +E+ IP W + Sbjct 431 QMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQ 490 Query 449 CIRITLCA----------------------SAVFFWILLIIASVIGIIVYRLSVFIVFSA 486 ++ + ++ F I + A V+G+I+YR+S+ + Sbjct 491 RVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALA- 549 Query 487 KLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDY 546 +N + ++ + + + TA II+ ++I++L+ +Y +A +T E+P+T+ + Sbjct 550 -----MNSSPSVRSNI--RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSF 602 Query 547 ENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTT 606 E L K FL +FVN Y+ FY+AFFKG+FVG PGD VY +R EEC PGGCL+EL Sbjct 603 EERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCI 662 Query 607 QLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSE--------KITPRWEQDYHLQP 657 QL+IIM GK I NN+ E+ +P + LI R+ ++ K R+E DY+L+P Sbjct 663 QLSIIMLGKQLIQNNLFEIGIPKMKKLI-RYLKLKQQSPPDHEECVKRKQRYEVDYNLEP 721 Query 658 MGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEK 717 GL EY+EMIIQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K T+ RR V + Sbjct 722 FA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVR 779 Query 718 AQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYIN 777 A+DIG W I++GI LAV+ NA +I+FTSD IPRLVY + +S + TM G++N Sbjct 780 AKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYS-------KNGTMHGFVN 832 Query 778 NTLSIFKVADFKNKSKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836 +TLS F V+DF+N + N DLG CRY+D+R PP +Y + +W V+AA+LA Sbjct 833 HTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLA 892 Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLL 878 F+IV ++++ + F+ + IPD+ K +I +EK L +L Sbjct 893 FVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELF 934 >sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2 PE=1 SV=2 Length=1002 Score = 556 bits (1434), Expect = 0.0, Method: Compositional matrix adjust. Identities = 330/894 (37%), Positives = 483/894 (54%), Gaps = 97/894 (11%) Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97 + F+D QR++D+VL Y E+ KE + G + + Sbjct 90 MHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLD 149 Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146 A E NL+ GL+LE VFV++HAPW+VL AE + IK+P Sbjct 150 ALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPT 209 Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVD 198 K + + F+ +L S ++P + + PF + +M + I + Sbjct 210 K--KMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQE 267 Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258 +D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D Sbjct 268 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPGDD 325 Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318 N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV Sbjct 326 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 382 Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378 FLYG + SKE+C D MCP CD+ C +W L+ C +++ +FD+ T Sbjct 383 VFLYGCATIEEDIPSKEMC--DHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPAT 440 Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433 + F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E Sbjct 441 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKE 500 Query 434 -----ITQEEERIPFTAWGKCIRIT---------LCASAVFFWILLIIASVIGIIVYRLS 479 + + E P ++T + +++ F I L + V G+IVYR++ Sbjct 501 SGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT 560 Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539 S N + + TA II+ ++I+IL+ IY VA +T E+ Sbjct 561 TAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEV 610 Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599 P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PGG Sbjct 611 PKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGG 670 Query 600 CLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSEKITP-------RWEQ 651 CL+EL QL+IIM GK I NNI E+ +P + L + + + P +W+ Sbjct 671 CLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDL 730 Query 652 DYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFR 711 D+ L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+ R Sbjct 731 DHSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELR 788 Query 712 RLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT 771 R + +DIG W I+ GI +V+ NA +IA TSD IPRLVY +S+S H T Sbjct 789 RPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYS------HNG-T 841 Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVI 831 + G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW V+ Sbjct 842 LHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVL 901 Query 832 AAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884 +A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K Sbjct 902 SARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 955 >sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 PE=1 SV=2 Length=1003 Score = 555 bits (1429), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/895 (37%), Positives = 483/895 (54%), Gaps = 97/895 (11%) Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97 + F+D QR++D+VL Y E+ KE + G + + Sbjct 90 MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 149 Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146 A E NL+ GL+LE +FV++HAPW+VL AE + IK+P Sbjct 150 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 209 Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 198 K ++ + F+ L S ++P + + + PF + +M + I + Sbjct 210 K-KEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 268 Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258 +D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D Sbjct 269 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 326 Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318 N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV Sbjct 327 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 383 Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378 FLYG + S+E+C D MCP CD+ C +W L+ C +++ +FD+ T Sbjct 384 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 441 Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433 + F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E Sbjct 442 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 501 Query 434 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478 Q E++ T + + +++ F I L + V G+IVYR+ Sbjct 502 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 561 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 + S N + + TA II+ ++I+IL+ IY VA +T E Sbjct 562 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 611 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 +P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PG Sbjct 612 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 671 Query 599 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 650 GCL+EL QL+IIM GK I NNI E+ +P + L + S K +W+ Sbjct 672 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 731 Query 651 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 710 DY L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+ Sbjct 732 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 789 Query 711 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 770 RR + +DIG W I+ GI +V++NA +IA TSD IPRLVY +S+S H Sbjct 790 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 842 Query 771 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 830 T+ G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW + Sbjct 843 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 902 Query 831 IAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884 ++A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K Sbjct 903 LSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 957 >sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7 PE=1 SV=2 Length=859 Score = 533 bits (1374), Expect = 2e-175, Method: Compositional matrix adjust. Identities = 312/825 (38%), Positives = 475/825 (58%), Gaps = 57/825 (7%) Query 69 IDFVLVYEDESRKETN-KKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125 IDFVLV+E++ R + N K + R+ + NL GL+++ V D+ ++ Sbjct 55 IDFVLVWEEDLRNQENPTKDKTDTHEVWRETFLENLCLAGLKID-QHDVQDEAAAVHYIL 113 Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183 + APW VLC YAE + +KLPL+ PN N S+ L W + E + E+++ Sbjct 114 LRAPWAVLCYYAEDLRLKLPLQELPNQASNWSATL--LEWLGIPNILLEHVPDTPPEYYS 171 Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242 F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++ Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKGLFGIDQLLAEGVFS 230 Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA Sbjct 231 AAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFA 290 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L Sbjct 291 WLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSS--DSFDMCPLCSD-CSFWLL 347 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419 + C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478 P++ A +N IT E+E P+ +R L S V ++ + I ++ +I+YR Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSVILYRA 465 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 + I+ ++ +D S+T S+++ + I+IL+ +Y +A ++T +E Sbjct 466 VMAII--------VSRSDNAFLSAWASRIASLTGSVVNLVFILILSKVYVLLAQVLTRWE 517 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 + RTQT++E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ + L RNEEC G Sbjct 518 MHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGN-YHTLFGIRNEECPAG 576 Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHR--VSGSEKITPRWEQDYHLQ 656 GCL EL +L +IM GK I NN+QEVL+P + +F R +G+ WE DY L Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKFSRGKKAGTGTHPAPWEADYELL 636 Query 657 PMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPE 716 P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V E Sbjct 637 PCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAE 694 Query 717 KAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYI 776 +AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G++ Sbjct 695 RAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYSWTHAP---------DLHGFL 745 Query 777 NNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836 N TL ++ P ++ TCRYR FR GH ++ YW ++A +LA Sbjct 746 NFTL-----------ARAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRLA 789 Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHEN 881 F+IV EHV++S+ + +PD+ + + K++RE YL ++ L EN Sbjct 790 FVIVFEHVVFSIGRVLDLLVPDIPESVEIKVKREYYLAKQALAEN 834 >sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=Ano7 PE=2 SV=1 Length=860 Score = 530 bits (1366), Expect = 3e-174, Method: Compositional matrix adjust. Identities = 319/844 (38%), Positives = 484/844 (57%), Gaps = 66/844 (8%) Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125 IDFVLV+E++ R +E + + R+ + NL GL+++ R V D+ ++ Sbjct 55 IDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKID-QRDVQDEAAAVHYIL 113 Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183 + APW VLC YAE + +KLPL+ PN N S+ L W + E++ E+++ Sbjct 114 LSAPWAVLCYYAEDLRLKLPLQELPNQASNWSATL--LEWLGIPNILLENVPDTPPEYYS 171 Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242 F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++ Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-QKKGLFGIDQLLAEGVFS 230 Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA Sbjct 231 AAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFA 290 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L Sbjct 291 WLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSS--DTFDMCPLCSD-CSFWLL 347 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419 + C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478 P++ A +N IT E+E P+ +R L S V ++ + I ++ II+YR Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSIILYRA 465 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTA--TSITASIISFIIIMILNTIYEKVAIMITN 536 + I+ S K+ N +L+ + S+T S+++ + I+IL+ +Y +A ++T Sbjct 466 VMAIIVS----KSNNA------FLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTR 515 Query 537 FELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECD 596 +E+ RTQT +E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ + L RNEEC Sbjct 516 WEMHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGN-YHTLFGVRNEECP 574 Query 597 PGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWI----MNLIGRFHRVSGSEKITPRWEQD 652 GGCL EL +L +IM GK I NN+QEVL+P + L R + P WE D Sbjct 575 AGGCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMGANPAP-WEAD 633 Query 653 YHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712 Y L P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR Sbjct 634 YELLPCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRR 691 Query 713 LVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTM 772 V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + Sbjct 692 PVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWT---------RAPDL 742 Query 773 EGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIA 832 G++N TL ++ P ++ TCRYR FR GH ++ YW ++A Sbjct 743 RGFLNFTL-----------ARAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLA 786 Query 833 AKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGV 892 +LAF+IV EHV++S F+ +PD+ + + K++RE YL ++ L +N + + GV Sbjct 787 IRLAFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADN--EALLGATGV 844 Query 893 IAER 896 E+ Sbjct 845 KGEQ 848 >sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 PE=1 SV=2 Length=933 Score = 525 bits (1352), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 318/839 (38%), Positives = 477/839 (57%), Gaps = 69/839 (8%) Query 67 RRIDFVLVYEDE----SRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV 122 R DFVLV+E++ ++++ + + R R+ + NL GL ++ + V D Sbjct 108 RIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVD-QQDVQDGNTT 166 Query 123 --FVKVHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178 + + A W VLC YAE + +KLPL+ PN N S+ G L W + E + Sbjct 167 VHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSA--GLLAWLGIPNVLLEVVPDVP 224 Query 179 QEFFTAPFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVN 237 E+++ F N++ F D +D FF R +I++ IL++ Y + GI++L+ Sbjct 225 PEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYG-HEKKNLLGIHQLLA 283 Query 238 SGIYKAAFPLHDCKFRRQSEDPSCP--NERYLLYREWAHPRSIYKKQPLDLIRKYYGEKI 295 G+ AAFPLHD F+ E P P N+R +L++ WA K QPLD +R+Y+GEK+ Sbjct 284 EGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKV 343 Query 296 GIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGK--IIMCPQCDR 353 +YFAWLG+YT LL AAVVG FL G + ++E+C G K MCP C Sbjct 344 ALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELC----GSKDSFEMCPLCLD 399 Query 354 LCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQ 413 CPFW L+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + Sbjct 400 -CPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYE 458 Query 414 Q-EEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIG 472 EE+ RP++ A N IT E+E F + R+ + + + +++ ++ Sbjct 459 DTEERPRPQFAASAPMTAPNPITGEDEPY-FPERSRARRMLAGSVVIVVMVAVVVMCLVS 517 Query 473 IIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAI 532 II+YR + IV S +G + + + S+T S+++ + I+IL+ IY +A Sbjct 518 IILYRAIMAIVVSR------SGNTLLAAWAS--RIASLTGSVVNLVFILILSKIYVSLAH 569 Query 533 MITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRN 592 ++T +E+ RTQT +E++ T+K+F+FQFVN+YSS YIAFFKG+FVGYPG+ + L RN Sbjct 570 VLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGN-YHTLFGVRN 628 Query 593 EECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR---- 648 EEC GGCL+EL +L +IM GK + NN+QEVL+P + +F S K Sbjct 629 EECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGAS 688 Query 649 ---WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWK 705 WE DY L P GLF EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K Sbjct 689 QGPWEDDYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARK 746 Query 706 LTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYG 765 ++RR V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR Y W+ Sbjct 747 FVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWT------- 799 Query 766 DHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHT-TCRYRDFRYPPGHPQEYKHN 824 ++ + G++N TL+ P S H TCRYR FR GH ++ Sbjct 800 --RAHDLRGFLNFTLA------------RAPSSFAAAHNRTCRYRAFRDDDGH-----YS 840 Query 825 IYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHL 883 YW+++A +LAF+IV EHV++SV + +PD+ + + K++RE YL ++ L EN + Sbjct 841 QTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEV 899 >sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 PE=1 SV=3 Length=782 Score = 429 bits (1103), Expect = 2e-136, Method: Compositional matrix adjust. Identities = 252/692 (36%), Positives = 395/692 (57%), Gaps = 77/692 (11%) Query 206 ATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263 + R RIV F+ V+NN + G L+ G+++A FPLH + R Sbjct 117 SLRIRIVNFV-------VMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR---------- 159 Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323 L + WA R ++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G Sbjct 160 ----LKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSG 215 Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383 + + SKE+C I+MCP D + +L+ TC +K +FD+ GT+VFA+ Sbjct 216 FSLFEASQISKEICE---AHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAI 272 Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTV--ELQQEEQAR-----PEYEARCTHVVINEITQ 436 FM +W T+FLE WKR++A + WD + +QEE A P+Y+ R Sbjct 273 FMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLR----------- 321 Query 437 EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTD 496 P+ +R T+ I L+I ++VYR+ +FS+ + Sbjct 322 -----PYQH--SYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSS------SAVP 368 Query 497 PIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFL 556 +++ +T TA +T +++ ++ I+I+ I VA+ + +FE+PRT ++ E+ T++ F Sbjct 369 FLEEQVT--TAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFT 426 Query 557 FQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA 616 QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+ IIMG K Sbjct 427 LQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQ 486 Query 617 IWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR------WEQDYHLQPMGKLGLFYEYLEM 670 +N E L+PW+ + R R S S + PR W ++Y L P+ LF E++EM Sbjct 487 TLSNCVEYLVPWVTHKC-RSLRASESGHL-PRDPELRDWRRNYLLNPVNTFSLFDEFMEM 544 Query 671 IIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQG 730 +IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG W +++ Sbjct 545 MIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLET 604 Query 731 IAILAVVTNAMIIAFTSDMIPRLVYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFK 789 I +LAV+ N M+IAFTS+ IPR+VY + +S G+ T ++GY+N++LS+F DF+ Sbjct 605 IGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQ 664 Query 790 NKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVK 849 + G S+ N T CRYRD+R PP +Y + +W ++A +LAF+I+ EHV +K Sbjct 665 DPD-GIEGSE--NVTLCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIK 717 Query 850 FFISYAIPDVSKRTKSKIQREKY--LTQKLLH 879 ++ +PD+ + K+K+ KY L +K+ H Sbjct 718 LIAAWFVPDIPQSVKNKVLEVKYQRLREKMWH 749 >sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9 PE=1 SV=1 Length=747 Score = 384 bits (986), Expect = 1e-119, Method: Compositional matrix adjust. Identities = 238/692 (34%), Positives = 382/692 (55%), Gaps = 82/692 (12%) Query 198 DRDAFFNPATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQ 255 D +F TR RIV F V+NN K G LV G+++ F LH + Sbjct 105 DEQSFNIATTRIRIVSF--------VVNNKLKPGDTFEDLVKDGVFETMFLLHKGEQN-- 154 Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315 L WA R++++ QP+D IR+Y+GEK+ +YF WLG+YT ML+ AAVV Sbjct 155 ------------LKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVV 202 Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375 G+ FL G+ D+ SKE+C + I MCP D + +L+ C +K +FD+ Sbjct 203 GLIVFLSGFALFDSSQISKEICSAN---DIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDN 259 Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQA-ELE----YEWDTVE--LQQEEQARPEYEARCTH 428 GT++FA+FM +W T+FLE WKR++A E++ YEWD E + E P Y+ + Sbjct 260 EGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLK--- 316 Query 429 VVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488 + R + + + ++L F I L+I ++VYR+ +FS+ + Sbjct 317 ---------DHRHSYLSSTIILILSL------FMICLMIGMAHVLVVYRVLAGALFSSLV 361 Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548 + + TA +T +++ +III+I+ + + VA+ + FE T ++ E Sbjct 362 KQQV------------TTAVVVTGAVVHYIIIVIMTKVNKYVALKLCKFEESGTFSEQER 409 Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608 T+K F+ QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+ Sbjct 410 KFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQM 469 Query 609 TIIMGGKAIWNNIQEVLLP-----WIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL 663 IIMG K +N E L P W + + +S ++ W+++Y++ P+ L Sbjct 470 AIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPEL-KEWQRNYYMNPINTFSL 528 Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723 F E++EM+IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG Sbjct 529 FDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGT 588 Query 724 WQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT---MEGYINNTL 780 W +++ I +LAV+ N M+IAFTS+ IPR+VY + + P + ++T + Y+N++L Sbjct 589 WLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYG--PCRTNRTFTDDCLTNYVNHSL 646 Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 S+F F + S+ N T CRYRD+R + +Y + +W ++A +L F+I+ Sbjct 647 SVFYTKHFNDHSRMEGQE---NVTVCRYRDYR----NEHDYNLSEQFWFILAIRLTFVIL 699 Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872 EH +K ++ +PDV ++ K+++ +EKY Sbjct 700 FEHFALCIKLIAAWFVPDVPQKVKNEVLQEKY 731 >sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO10 PE=1 SV=2 Length=660 Score = 171 bits (433), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 145/525 (28%), Positives = 238/525 (45%), Gaps = 115/525 (22%) Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291 + RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+ Sbjct 158 LRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFALKYQPIDSIRGYF 204 Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351 GE I +YF +L Y+T L+ AV+G+ +L+ + + D Sbjct 205 GETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDK---------------------- 242 Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411 ++FA F +W T+ LE WKR A + Y W T+ Sbjct 243 --------------------------YVIFASFNLIWSTVILELWKRGCANMTYRWGTLL 276 Query 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470 ++++ E+ RP + IN IT +EE + + ++ + +RI L S F + L + Sbjct 277 MKRKFEEPRPGFHGVLG---INSITGKEEPL-YPSYKRQLRIYLV-SLPFVCLCLYFSLY 331 Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530 + +I + + V+ + L +N +G++ L SII I+I I+N +Y Sbjct 332 VMMIYFDMEVW---ALGLHEN-SGSEWTSVLL-------YVPSIIYAIVIEIMNRLYRYA 380 Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590 A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF Sbjct 381 AEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--------------- 425 Query 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKI----- 645 + L L ++ I N I E LP+ + R H V K+ Sbjct 426 ----------MKLLRQSLATLLITSQILNQIMESFLPYWLQ---RKHGVRVKRKVQALKA 472 Query 646 ---TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701 +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+ Sbjct 473 DIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS 532 Query 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 DA K+ F+R E + +IG WQ + +++++VVTN +I + Sbjct 533 DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577 Score = 39.3 bits (90), Expect = 0.20, Method: Compositional matrix adjust. Identities = 14/53 (26%), Positives = 35/53 (66%), Gaps = 0/53 (0%) Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890 ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+ Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647 >sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=Ano10 PE=1 SV=1 Length=659 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 139/522 (27%), Positives = 238/522 (46%), Gaps = 109/522 (21%) Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291 + RL+ SGI FPLHD + ++ ED W + R K QP+D IR Y+ Sbjct 158 MRRLLTSGIVTQVFPLHDTEALKKLEDT------------W-YTRFALKYQPIDSIRSYF 204 Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351 GE I +YF +L Y+T L+ A++G+ +L+ + + D Sbjct 205 GETIALYFGFLEYFTFALIPMAIIGLPYYLFVWEDYDK---------------------- 242 Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411 ++FA F +W T+ LE WKR A + Y W T+ Sbjct 243 --------------------------YVIFASFNLIWSTVILEVWKRGCANMTYRWGTLV 276 Query 412 LQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470 ++++ E+ RP + IN +T EE + ++++ + +RI L S F + L + Sbjct 277 MKRQFEEPRPGFHGVLG---INSVTGREEPL-YSSYKRQLRIYL-VSLPFVCLCLYFSLY 331 Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530 + +I + + + + L ++ +G++ L SI+ ++I I+N +Y Sbjct 332 VMMIYFDMEDW---ALSLHED-SGSEWTSLLL-------YVPSIVYAVVIEIMNRLYRYA 380 Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590 A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF Sbjct 381 AEFLTSWENHRLESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKD--------------- 425 Query 591 RNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----IGRFHRVSGSEKI 645 + L L ++ I N + E LLP+ + + R + SE Sbjct 426 ----------MKLLRQSLATLLITSQILNQVVESLLPYWLQRKYCARVKRKVQALKSEVD 475 Query 646 TPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAW 704 T +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A++NN E+ DA Sbjct 476 TTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDAL 535 Query 705 KLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 K+ F+R E + IG WQ + +++++VVTN +I + Sbjct 536 KMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGMS 577 Score = 37.7 bits (86), Expect = 0.52, Method: Compositional matrix adjust. Identities = 13/53 (25%), Positives = 34/53 (64%), Gaps = 0/53 (0%) Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890 ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K + +N+ Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQQKLARLEFESLEALKQQQMKLVAENL 647 >sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano10 PE=2 SV=1 Length=646 Score = 164 bits (414), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 150/532 (28%), Positives = 233/532 (44%), Gaps = 129/532 (24%) Query 232 INRLVNSGIYKAAFPLHDCK-FRRQSEDPSCPNERYLLYREWAHPRSIYKK-----QPLD 285 + RL + G+ FPLH+ + +R S S YKK QPLD Sbjct 158 VRRLQSKGVLVQYFPLHNKEDLKRLS-------------------FSWYKKIKLSFQPLD 198 Query 286 LIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKI 345 IR Y+GE +G+YF +L Y+T L+ A++G+ +L+ + + D Sbjct 199 DIRSYFGEGLGLYFGFLEYFTFALIPMALIGIPYYLFDWEDYDK---------------- 242 Query 346 IMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEY 405 ++FAVF VW T+FLE WKR A L Y Sbjct 243 --------------------------------YVLFAVFNLVWSTVFLEVWKRCSATLAY 270 Query 406 EWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWIL 464 W T+ ++ E+ R + +N +T EE I + + + +RI L + V F +L Sbjct 271 SWGTLGRKKAFEEPRAGFHGPLG---LNPVTGREEPI-YPSSKRHLRIYLVS--VPFVLL 324 Query 465 LIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSI---TASIISFIIIM 521 + S ++VY F S + P ATS+ SII ++I Sbjct 325 CLYLSFYVMMVYFDMEFWAISIY-------------HENPNFATSVLLFVPSIIYAVVIE 371 Query 522 ILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPG 581 I+N +Y A +T++E R ++ ++N L K+ +F FVN ++S FYIAF V Sbjct 372 IMNLLYRYAAEFLTDWENHRLESSFQNHLVPKVLVFNFVNCFASLFYIAFVMQDMV---- 427 Query 582 DPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMN------LIGR 635 L L ++ I N + E LP+ + + R Sbjct 428 ---------------------LLRQSLATLLITSQILNQVMEAFLPYWLQRRRNKRVYKR 466 Query 636 FHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVN 694 R+ G +++ P EQ M LG F +YLE + FG+V+LF PLA +L ++N Sbjct 467 MRRLMGDKEL-PLLEQIQLETEMNTYLGTFDDYLEQFLLFGYVSLFSCVHPLAAVLVVLN 525 Query 695 NILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 NI E+ DA+K+ F+R E A +IG WQ + ++I+AVVTN +IA + Sbjct 526 NITEVYSDAFKMCHVFKRPFSEPAANIGVWQLAFETMSIIAVVTNCALIALS 577 >sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 PE=1 SV=3 Length=1232 Score = 119 bits (297), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 101/380 (27%), Positives = 169/380 (44%), Gaps = 88/380 (23%) Query 202 FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIYKAAFPLHDCKFRR 254 FF R I+ F L ++ + ++NV I L GI + FP+H+ + Sbjct 159 FFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILN 218 Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314 + L + W ++ + QPLD I Y+G KI +YFAWLG+YT ++ AV Sbjct 219 R------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAV 264 Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374 G LY + D + +++C Sbjct 265 FG--SVLYTFTEADQTS----------------------------RDVSC---------- 284 Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQARPEYEARCTHVVIN 432 +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ RP++ I+ Sbjct 285 ----VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRR---IS 337 Query 433 EITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNI 492 IT+ EE + W + + L + + L +A ++ + + L F + +L ++ Sbjct 338 PITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLVCVFLLMLGCFQL--QELVLSV 388 Query 493 NGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTM 552 G + ++L ++ +++ + Y+K+AI + + E R ++ YE L + Sbjct 389 KGLPRLARFLP---------KVMLALLVSVSAEGYKKLAIWLNDMENYRLESAYEKHLII 439 Query 553 KMFLFQFVNYYSSCFYIAFF 572 K+ LFQFVN Y S FYI F+ Sbjct 440 KVVLFQFVNSYLSLFYIGFY 459 Score = 89.4 bits (220), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 39/81 (48%), Positives = 57/81 (70%), Gaps = 0/81 (0%) Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723 F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR DA+KL T +R ++ + IG Sbjct 745 FQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQ 804 Query 724 WQPIMQGIAILAVVTNAMIIA 744 WQ +M+ + +LA+V N +I Sbjct 805 WQKVMEAMGVLAIVVNCYLIG 825 >sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8 PE=1 SV=3 Length=1060 Score = 118 bits (296), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 101/380 (27%), Positives = 170/380 (45%), Gaps = 88/380 (23%) Query 202 FFNPATRSRIVYFILSRVKY---QVINNV----SKFGINRLVNSGIYKAAFPLHDCKFRR 254 FF R I+ F L ++ + ++NV + I L GI + FP+H+ + Sbjct 159 FFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILN 218 Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314 + L + W ++ + QPLD I Y+G KI +YFAWLG+YT ++ AV Sbjct 219 R------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAV 264 Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374 G LY + D + +++C Sbjct 265 FG--SVLYTFTEADQTS----------------------------RDVSC---------- 284 Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQARPEYEARCTHVVIN 432 +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ RP++ I+ Sbjct 285 ----VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRG---IRRIS 337 Query 433 EITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNI 492 IT+ EE + W + + L + + L +A +I + + L F + +L ++ Sbjct 338 PITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLICVFILMLGCFQL--QELVLSV 388 Query 493 NGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTM 552 G + ++L ++ +++ + Y+K+A+ + + E R ++ YE L + Sbjct 389 KGLPRLVRFLP---------KVMLALLVSVSAEGYKKLAVWLNDMENYRLESTYERHLII 439 Query 553 KMFLFQFVNYYSSCFYIAFF 572 K+ LFQFVN Y S FYI F+ Sbjct 440 KVVLFQFVNSYLSLFYIGFY 459 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 39/81 (48%), Positives = 56/81 (69%), Gaps = 0/81 (0%) Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723 F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR DA+KL T +R + + IG Sbjct 740 FQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQ 799 Query 724 WQPIMQGIAILAVVTNAMIIA 744 WQ +M+ + +LA+V N +I Sbjct 800 WQKVMEAMGVLAIVVNCYLIG 820 >sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryza sativa subsp. japonica OX=39947 GN=Os01g0706700 PE=2 SV=1 Length=665 Score = 115 bits (288), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 129/543 (24%), Positives = 212/543 (39%), Gaps = 131/543 (24%) Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291 + RL + GI K FPLHD R+Q L R WA + QP+D I Y+ Sbjct 158 LTRLEDEGIVKLVFPLHDEIKRKQ------------LLRSWALKWFDFTWQPIDEIYSYF 205 Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351 G KI IYF++LG YT+ L AV G+A Sbjct 206 GTKIAIYFSFLGMYTRWLFFPAVFGLAT-------------------------------- 233 Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLV---FAVFMGVWVTLFLEFWKRRQAELEYEWD 408 +L F S LV F F+ W FL+FWKR+ + + W Sbjct 234 -----------------QLIDFGSLQWLVLPAFFFFVISWAVFFLQFWKRKNSAVLARWG 276 Query 409 TVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIA 468 + EY+ + + ++ + +G ++ +F +LL I Sbjct 277 I------NYSFSEYKTMGNELDPLSFSMADDNVQQRKFGAPKEKSIVQRNEWFGVLLRIR 330 Query 469 S----VIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILN 524 + V+ II +L + ++ I T+ ++ LT + I Sbjct 331 NNAIIVLAIICLQLPFELAYAHLYA--ITKTEALRYVLTA----------VYLAAIQYYT 378 Query 525 TIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPV 584 I KV++ + +E + + +SL K+F F+ Y FY A Sbjct 379 RIGGKVSVTLIKYENNQGEQSSADSLVYKVFGLYFMQSYIGLFYHA-------------- 424 Query 585 YWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV----- 639 +RN ++ L L + + N+ E +P++ ++ V Sbjct 425 ---SLHRN--------IMALRQVLIKRLIVSQVLENLIENSIPYLNYSYKKYRAVHKKKH 473 Query 640 ------SGSEKITPRWEQDYHLQP-----MGKL---GLFYEYLEMIIQFGFVTLFVASFP 685 S +++ R E++Y L+P +G+ GLF ++LE+ +QFG + +F +FP Sbjct 474 EKESPAGKSVRLSTRVEKEY-LKPSYTASIGEELEDGLFDDFLELTLQFGMIMMFACAFP 532 Query 686 LAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAF 745 A +NN+ EIR DA KL +R P A IGAW I Q + ++A+ TN +++ Sbjct 533 SIFCFAALNNVTEIRADALKLLVMLKRPAPRDAATIGAWLNIFQFLVVMAICTNCLLLVC 592 Query 746 TSD 748 D Sbjct 593 LYD 595 >sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabidopsis thaliana OX=3702 GN=At1g73020 PE=1 SV=1 Length=665 Score = 102 bits (253), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 139/553 (25%), Positives = 221/553 (40%), Gaps = 151/553 (27%) Query 232 INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYY 291 + RL + G+ K FPLHD R++ L + WA QP+D I Y+ Sbjct 145 LRRLESEGVIKQMFPLHDELKRKE------------LLQNWALNWWNCTNQPIDQIYSYF 192 Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351 G KIG+YF++LG YTQ L+ A L G++ Q Sbjct 193 GAKIGVYFSFLGMYTQWLIFPA-------LLGFIVQ------------------------ 221 Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVF----AVFMG--VWVTLFLEFWKRRQAELEY 405 FG+L F + F+G +W LFL+FWKR+ A L Sbjct 222 ---------------------MVDFGSLQFLALPSFFVGTILWAALFLQFWKRKNAALLA 260 Query 406 EWDTVELQQEEQ---------ARPEYEARCTHVVINEITQEEE---RIPFTAWGKCIRIT 453 W L Q + + + NE +E+E R + A+ K R Sbjct 261 RWQINCLVGPSQGYRFLGMEWSSLPFPKELIKNLGNERAKEKEAYQRYEWFAYRKRFRND 320 Query 454 LCASAVFFWILLIIASVIGI-IVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITA 512 + L+I S+I + + + L+ +F I +D I+ LT Sbjct 321 V----------LVIMSIICLQLPFELAYAHIF------EIITSDIIKYVLTA-------- 356 Query 513 SIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFF 572 I +II L + KV++ + N E+ + NSL K+F F+ Y FY Sbjct 357 --IYLLIIQYLTRLGGKVSVKLINREINESVEYRANSLIYKVFGLYFMQTYIGIFYHVLL 414 Query 573 KGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL 632 F+ L ++ Q II + W + + LP++ Sbjct 415 HRNFM----------------------TLRQVLIQRLII--SQVFWT-LMDGSLPYLKYS 449 Query 633 IGRFH----------RVSGSEKITPRWEQDY----HLQPMG---KLGLFYEYLEMIIQFG 675 ++ +G +I R E++Y + +G + GLF + LE+ +QFG Sbjct 450 YRKYRARTKKKMEDGSSTGKIQIASRVEKEYFKPTYSASIGVELEDGLFDDSLELALQFG 509 Query 676 FVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 735 + +F +FPLA LA V+N++EIR +A KL RR +P A IGAW I Q + +++ Sbjct 510 MIMMFACAFPLAFALAAVSNVMEIRTNALKLLVTLRRPLPRAAATIGAWLNIWQFLVVMS 569 Query 736 VVTNAMIIAFTSD 748 + TN+ ++ D Sbjct 570 ICTNSALLVCLYD 582 >sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pi030 PE=4 SV=1 Length=668 Score = 100 bits (249), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 108/484 (22%), Positives = 198/484 (41%), Gaps = 104/484 (21%) Query 380 VFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEE 439 +FA+ + +W F++FW+ ++ +L W TV Q ++ E++ + V + Sbjct 212 IFAIGVALWGAFFIQFWRVQEHKLTNHWSTVNCQSLAKSMTEFKPQSYRV---DSLLGTA 268 Query 440 RIPFTAWGKCIRITLCASAVFF---WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTD 496 R + W +R T+ +F ILL + ++ I+ LS V+S L Sbjct 269 RPYYPQWEIIVRSTIANVPLFLISGCILLFLIAIAFIVDVTLSE--VYSGPL-------- 318 Query 497 PIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFL 556 ++ S+ +++ ++ + IY VA +T E RT+TD++ SL+ KMFL Sbjct 319 --------KSIVSLLPAVVFQVLTLPFTFIYSIVAERLTKLENRRTKTDFQASLSGKMFL 370 Query 557 FQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL--------LELTTQL 608 F+ Y++ F I++ G F Y P Y + G L L Q Sbjct 371 QNFMLSYTALFLISYIYGPFAEY-FVPHYIQNRMSQSFFSVGYIAKSTFKLNPLRLRNQY 429 Query 609 TIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQ--PMGKLGL--- 663 + + N I + +P +++ + + H +S + + H+Q P + L Sbjct 430 IYFLTNAQVINYITILAVPQLISYVKK-HYMSKPTR-------ELHIQDIPSETVTLKRA 481 Query 664 -----------FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR 712 + +Y + ++ FGF+ +F +PLAP+ +LVN +L IR ++ T ++ Sbjct 482 RSEAEKIEYDCYNDYKDFVLMFGFLVMFSPIYPLAPIFSLVNCVLYIRSSVYRFTKMVKK 541 Query 713 LVPEKAQDIGAWQPIMQGIAILAVVT----------------NAMIIA------------ 744 VP + I W + ++ L +T +M+IA Sbjct 542 PVPCRVDSIAPWDQRLSLLSWLGCITMPSICYFYSSTTKPSDKSMVIAAVIGLLSEHLWF 601 Query 745 ----FTSDMIP-------------RLVYYWSFSVPPYGDHTSYTMEGY--INNTLSIFKV 785 F S + P L+ SFS+PP D + T + + TLSI++ Sbjct 602 LLRMFISSVFPVDKTFFAPAKERQHLLAERSFSIPPVADVPTSTTTAFEEADETLSIYRT 661 Query 786 ADFK 789 A+ K Sbjct 662 AENK 665 >sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=IST2 PE=1 SV=2 Length=946 Score = 41.2 bits (95), Expect = 0.052, Method: Compositional matrix adjust. Identities = 36/153 (24%), Positives = 63/153 (41%), Gaps = 29/153 (19%) Query 633 IGRFHRVSGSEKITPRWEQ--DYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPL 689 IG+ S KI W + Y P G L + ++++QFG++ +F +PLAP Sbjct 407 IGKAQLSSSDMKI---WSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVMFSTIWPLAPF 463 Query 690 LALVNNILEIRVDAWK-------------LTTQFRRLVPEKAQDIGAWQPIMQGIAILAV 736 + L+ N++ +VD K + + + + +G W ++ +IL Sbjct 464 ICLIVNLIVYQVDLRKAVLYSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGC 523 Query 737 VTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS 769 V A + Y S ++P G HTS Sbjct 524 VITATLTYM----------YQSCNIPGVGAHTS 546 >sp|Q2S8D3|F16PA_HAHCH Fructose-1,6-bisphosphatase class 1 OS=Hahella chejuensis (strain KCTC 2396) OX=349521 GN=fbp PE=3 SV=1 Length=336 Score = 35.4 bits (80), Expect = 2.2, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 44/106 (42%), Gaps = 8/106 (8%) Query 547 ENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYR-NEECDPGGCLLELT 605 E+ T + + +++ S F+ KG YP Y GK R EC+P L+E Sbjct 232 EDDATQRPYTSRYIGSLVSDFHRNLIKGGIYLYPTSSRYPEGKLRLLYECNPMAFLIEQA 291 Query 606 TQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQ 651 GGKAI N Q +L L R GS K+ + EQ Sbjct 292 -------GGKAIANPGQRILDIEPTKLHQRCPLFVGSPKMVDKLEQ 330 >sp|Q9VNS0|MAEL_DROME Protein maelstrom OS=Drosophila melanogaster OX=7227 GN=mael PE=1 SV=1 Length=459 Score = 34.7 bits (78), Expect = 4.5, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 38/89 (43%), Gaps = 15/89 (17%) Query 83 TNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHI 142 + K N QR KR++ + Q EAT S++D K E L A++ H Sbjct 52 SGGKDANVAQRAKRESSNGHGQVDKAQREATESLMDMKRTI-------ERLVLNAKMSH- 103 Query 143 KLPLKPNDLKNRSSAFGTLNWFTKVLSVD 171 DL+N F N+FTK L+ D Sbjct 104 -------DLENAKFVFVAFNYFTKALTTD 125 >sp|Q12202|OSW2_YEAST Outer spore wall protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=OSW2 PE=4 SV=2 Length=724 Score = 34.3 bits (77), Expect = 5.8, Method: Compositional matrix adjust. Identities = 24/86 (28%), Positives = 38/86 (44%), Gaps = 10/86 (12%) Query 260 SCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVAC 319 S P E Y Y + +P I QP+ L +KY + F + G+YT++L L+ + Sbjct 325 SLPFEPYCFYHRFEYPAQILLHQPIILAKKYGVSCSNLNFLY-GFYTRLLTLSGLS---- 379 Query 320 FLYGYLNQDNCTWSKEVCHPDIGGKI 345 +N C + + IGG I Sbjct 380 -----INGGRCEHALSMLDSRIGGGI 400 >sp|Q1KXV4|NU3C_HELAN NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic OS=Helianthus annuus OX=4232 GN=ndhC PE=3 SV=1 Length=120 Score = 32.3 bits (72), Expect = 7.4, Method: Composition-based stats. Identities = 17/42 (40%), Positives = 28/42 (67%), Gaps = 4/42 (10%) Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNI----NGTDPI 498 FW LII+S+I I+V+ +S F+ S+K P+ + +G +PI Sbjct 10 FWAFLIISSLIPILVFFISGFLAPSSKGPEKLSSYESGIEPI 51 >sp|B2LMJ8|NU3C_GUIAB NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic OS=Guizotia abyssinica OX=4230 GN=ndhC PE=3 SV=1 Length=120 Score = 32.3 bits (72), Expect = 7.4, Method: Composition-based stats. Identities = 17/42 (40%), Positives = 28/42 (67%), Gaps = 4/42 (10%) Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNI----NGTDPI 498 FW LII+S+I I+V+ +S F+ S+K P+ + +G +PI Sbjct 10 FWAFLIISSLIPILVFFISGFLAPSSKGPEKLSSYESGIEPI 51 >sp|Q6R799|Y120_OSHVF Uncharacterized protein ORF120 OS=Ostreid herpesvirus 1 (isolate France) OX=654903 GN=ORF120 PE=3 SV=1 Length=76 Score = 30.8 bits (68), Expect = 8.6, Method: Composition-based stats. Identities = 11/19 (58%), Positives = 12/19 (63%), Gaps = 0/19 (0%) Query 347 MCPQCDRLCPFWKLNITCE 365 +C CDRLCP N TCE Sbjct 44 ICQDCDRLCPLISDNPTCE 62 Lambda K H a alpha 0.324 0.140 0.435 0.792 4.96 Gapped Lambda K H a alpha sigma 0.267 0.0410 0.140 1.90 42.6 43.6 Effective search space used: 105226848522 Results from round 2 Query= sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 PE=1 SV=2 Length=910 Score E Sequences producing significant alignments: (Bits) Value Sequences used in model and found again: sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 ... 1259 0.0 sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6... 1225 0.0 sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5... 1068 0.0 sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 ... 1065 0.0 sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4... 1047 0.0 sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1... 1045 0.0 sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 ... 1039 0.0 sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE... 1032 0.0 sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 ... 1028 0.0 sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 ... 990 0.0 sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3... 990 0.0 sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 ... 988 0.0 sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2... 982 0.0 sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7... 958 0.0 sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=A... 956 0.0 sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 ... 944 0.0 sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 ... 727 0.0 sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9... 686 0.0 sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO... 422 3e-135 sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=An... 421 7e-135 sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano1... 390 3e-123 sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryz... 376 1e-117 sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabido... 336 2e-102 sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosa... 312 3e-93 sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 ... 285 6e-80 sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8... 283 1e-79 Sequences not found previously or not previously below threshold: sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Sacc... 87.9 2e-16 sp|Q9SZT4|CSCLE_ARATH CSC1-like protein At4g35870 OS=Arabidopsis ... 46.7 0.001 sp|A0RPL5|TGT_CAMFF Queuine tRNA-ribosyltransferase OS=Campylobac... 40.5 0.055 sp|B9L8E1|TGT_NAUPA Queuine tRNA-ribosyltransferase OS=Nautilia p... 39.0 0.20 sp|Q5HUF2|TGT_CAMJR Queuine tRNA-ribosyltransferase OS=Campylobac... 36.3 1.2 sp|Q1EPG7|CSPL1_MUSAC CASP-like protein 1E1 OS=Musa acuminata OX=... 35.1 1.7 sp|A7GYD5|TGT_CAMC5 Queuine tRNA-ribosyltransferase OS=Campylobac... 35.5 2.1 sp|Q5YCC5|TMC7_CHICK Transmembrane channel-like protein 7 OS=Gall... 35.1 3.4 sp|A1VZZ8|TGT_CAMJJ Queuine tRNA-ribosyltransferase OS=Campylobac... 34.7 3.5 sp|B6EK65|TGT_ALISL Queuine tRNA-ribosyltransferase OS=Aliivibrio... 34.7 3.5 sp|Q96NT0|CC115_HUMAN Coiled-coil domain-containing protein 115 O... 34.0 3.6 sp|Q8VZM5|CSCL3_ARATH CSC1-like protein At4g15430 OS=Arabidopsis ... 34.7 4.6 sp|Q5YCC7|TMC3_CHICK Transmembrane channel-like protein 3 OS=Gall... 34.7 4.7 sp|Q62812|MYH9_RAT Myosin-9 OS=Rattus norvegicus OX=10116 GN=Myh9... 34.7 5.1 sp|Q9ULH1|ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH ... 34.7 5.3 sp|Q8VDD5|MYH9_MOUSE Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE... 34.3 6.4 >sp|Q4KMQ2|ANO6_HUMAN Anoctamin-6 OS=Homo sapiens OX=9606 GN=ANO6 PE=1 SV=2 Length=910 Score = 1259 bits (3258), Expect = 0.0, Method: Composition-based stats. Identities = 910/910 (100%), Positives = 910/910 (100%), Gaps = 0/910 (0%) Query 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL Sbjct 1 MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL 60 Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK Sbjct 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 Query 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE Sbjct 121 LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE 180 Query 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI Sbjct 181 FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI 240 Query 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA Sbjct 241 YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL Sbjct 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP Sbjct 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP 420 Query 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV Sbjct 421 EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV 480 Query 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP Sbjct 481 FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP 540 Query 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC Sbjct 541 RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC 600 Query 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK Sbjct 601 LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK 660 Query 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD Sbjct 661 LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD 720 Query 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL Sbjct 721 IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL 780 Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV Sbjct 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA Sbjct 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA 900 Query 901 VDNNLRPKSE 910 VDNNLRPKSE Sbjct 901 VDNNLRPKSE 910 >sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6 PE=1 SV=1 Length=911 Score = 1225 bits (3169), Expect = 0.0, Method: Composition-based stats. Identities = 821/912 (90%), Positives = 863/912 (95%), Gaps = 3/912 (0%) Query 1 MKKMSRNVLLQMEEEEDDDDGD-IVLENLGQTIV-PDLGSLESQHDFRTPEFEEFNGKPD 58 M+ M+R VLL ME EEDDD+ IVLEN QTIV P GSLE+Q DFRTPEFEEFNGKPD Sbjct 1 MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPD 60 Query 59 SLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLD 118 SLFF DGQRRIDF+LVYEDES+KE NKKGTNEKQ+RKRQAYESNLICHGLQLEATRSV D Sbjct 61 SLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSD 120 Query 119 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK RS FG LNWFTKVL V+ES+IKPE Sbjct 121 DKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSP-FGNLNWFTKVLRVNESVIKPE 179 Query 179 QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNS 238 QEFFTAPFEK+RMNDFYI+DRD+FFNPATRSRIVYFILSRVKYQV+NNV+KFGINRLV+S Sbjct 180 QEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSS 239 Query 239 GIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 298 GIYKAAFPLHDC+F +SED SCP+ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY Sbjct 240 GIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIY 299 Query 299 FAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFW 358 FAWLGYYTQMLLLAAVVGVACFLYGYL+QDNCTWSKEVC PDIGG+I+MCPQCDRLCPFW Sbjct 300 FAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFW 359 Query 359 KLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 418 +LNITCESSKKLCIFDSFGTL+FAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA Sbjct 360 RLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA 419 Query 419 RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478 RPEYEA+C HVVINEITQEEERIPFT GKCIR+TLCASAVFFWILLIIASVIGIIVYRL Sbjct 420 RPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRL 479 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 SVFIVFS LPKN NGTDPIQKYLTPQ ATSITASIISFIIIMILNTIYEKVAIMITNFE Sbjct 480 SVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFE 539 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVY LGKYR+EECDPG Sbjct 540 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPG 599 Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPM 658 GCLLELTTQLTIIMGGKAIWNNIQEVLLPW+MNLIGR+ RVSGSEKITPRWEQDYHLQPM Sbjct 600 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPM 659 Query 659 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRR+VPEKA Sbjct 660 GKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKA 719 Query 719 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINN 778 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS+PPYGDHT YTM+GYINN Sbjct 720 QDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINN 779 Query 779 TLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFI 838 TLS+F + DFKN K NPY LGN+T CRYRDFR PPGHPQEYKHNIYYWHVIAAKLAFI Sbjct 780 TLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFI 839 Query 839 IVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMI 898 IVMEH+IYSVKFFISYAIPDVSK TKSKI+REKYLTQKLLHE+HLKD+TKNMG+IAER+ Sbjct 840 IVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIG 899 Query 899 EAVDNNLRPKSE 910 VDN++RPK E Sbjct 900 GTVDNSVRPKLE 911 >sp|Q75UR0|ANO5_MOUSE Anoctamin-5 OS=Mus musculus OX=10090 GN=Ano5 PE=2 SV=1 Length=904 Score = 1068 bits (2762), Expect = 0.0, Method: Composition-based stats. Identities = 435/902 (48%), Positives = 595/902 (66%), Gaps = 45/902 (5%) Query 34 PDLGSLESQ----HDFRTPEFEEFN-------------GKPDSLFFNDGQRRIDFVLVYE 76 +LGS E+ D ++P + FN DS+FF DG R+IDFVL Y Sbjct 20 ENLGSKETSFLIPEDLQSPPEKRFNLFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYV 79 Query 77 DESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV--LDDKLVFVKVHAPWEVLC 134 ++ +K+ E + +R+ +E NL GL LE + D K FVK+HAPWEVL Sbjct 80 EDLKKD------GELKAERRREFEQNLRKTGLDLETEDKLNSEDGKTYFVKIHAPWEVLV 133 Query 135 TYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDF 194 TYAE++ IK+P+K +D+ + L++ + + S+ P E+FTA F ++R F Sbjct 134 TYAEVLGIKMPIKLSDIPRPK--YPPLSYMLGAVKLPSSVKYPTPEYFTAQFSRHRQELF 191 Query 195 YIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRR 254 I D FF +TR+RIVY+ILSR + V K GI RL+NS Y +A+PLHD ++ + Sbjct 192 LIEDEATFFPSSTRNRIVYYILSRCPFGVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWK 251 Query 255 QSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAV 314 S+ PNERY L + WA YK+QP LIR Y+GEKIGIYF +LGYYT+MLL AA+ Sbjct 252 PSKTT-RPNERYNLCKNWARFSYFYKEQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAAL 310 Query 315 VGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFD 374 VG+ACF+YG L+ +N S E+C PDIGG++IMCP CD +C +W+LN TC SK +FD Sbjct 311 VGLACFIYGLLSMENNRTSTEICDPDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFD 370 Query 375 SFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQA---RPEYEARCTHVVI 431 + T+ FA+FMG+WVTLFLEFWK+RQA LEYEWD V+ ++E+Q RPE+EA C H + Sbjct 371 NESTVFFALFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKM 430 Query 432 NEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKN 491 N +T+E E + + + V F + L+++S++ I++YRLSVF F++ + Sbjct 431 NPVTKEMEPH-MPLCHRIPWYFVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFMESE 489 Query 492 INGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLT 551 ++ + TPQ AT+++ S ++ I+I+ILN YEK++ IT E+PRT +YE+SLT Sbjct 490 AT-LQSVKSFFTPQLATALSGSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYESSLT 548 Query 552 MKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTII 611 +KMFLFQFVNYYSSCFY+AFFKGKFVGYPG Y +R+EEC P GCL+ELTTQLTII Sbjct 549 LKMFLFQFVNYYSSCFYVAFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTII 608 Query 612 MGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMI 671 M GK I+ NI E P I N R + SEK+ RWEQD+ LQ G GLFYEYLE + Sbjct 609 MIGKQIFGNIHEAFQPLIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYLETV 668 Query 672 IQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGI 731 IQFGF TLFVASFPLAPL AL+NNI+ IRVDAWKLTTQ+RR V KA IG WQ I+ G+ Sbjct 669 IQFGFATLFVASFPLAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILFGM 728 Query 732 AILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNK 791 AI++V TNA I++FTSD+IPRLVY++++S +++ + GY+NN+LS+F +ADF N Sbjct 729 AIVSVATNAFIVSFTSDIIPRLVYFYAYST-----NSTEPLSGYVNNSLSVFLIADFPNH 783 Query 792 SKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFF 851 + D TCRYRD+RYPP H +Y HN+ +WHV+AAK+ FIIVMEHV++ KF Sbjct 784 TVPMEKKDF---VTCRYRDYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFL 840 Query 852 ISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM----GVIAERMIEAVDNNLRP 907 +++ IPDV K KI+REK +T K++H+ L + +N+ G I + ++ DN+L+ Sbjct 841 LAWLIPDVPKDVVEKIKREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNSLKA 900 Query 908 KS 909 K+ Sbjct 901 KT 902 >sp|Q75V66|ANO5_HUMAN Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 PE=1 SV=1 Length=913 Score = 1065 bits (2754), Expect = 0.0, Method: Composition-based stats. Identities = 433/852 (51%), Positives = 597/852 (70%), Gaps = 23/852 (3%) Query 46 RTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLIC 105 R F++ DS+FF DG R+IDFVL Y D+ +K+ E + +R+ +E+NL Sbjct 57 RRLMFQKNQQSKDSIFFRDGIRQIDFVLSYVDDVKKDA------ELKAERRKEFETNLRK 110 Query 106 HGLQLEAT--RSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNW 163 GL+LE R D + FVK+HAPWEVL TYAE++ IK+P+K +D+ +++ Sbjct 111 TGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIKESDIPRPKHT--PISY 168 Query 164 FTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223 + + S+ P E+FTA F ++R F I D+ FF ++R+RIVY+ILSR + + Sbjct 169 VLGPVRLPLSVKYPHPEYFTAQFSRHRQELFLIEDQATFFPSSSRNRIVYYILSRCPFGI 228 Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQP 283 + +FGI RL+NS Y +A+PLHD ++ + SE P+ NERY L++ WA YK+QP Sbjct 229 EDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNPTNERYTLHQNWARFSYFYKEQP 288 Query 284 LDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGG 343 LDLI+ YYGEKIGIYF +LG+YT+ML AAVVG+ACF+YG L+ ++ T S E+C P+IGG Sbjct 289 LDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFIYGLLSMEHNTSSTEICDPEIGG 348 Query 344 KIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAEL 403 ++IMCP CD++C +W+LN TC +SK +FD+ T+ FA+FMG+WVTLFLEFWK+RQA L Sbjct 349 QMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFFAIFMGIWVTLFLEFWKQRQARL 408 Query 404 EYEWDTVELQQEEQA---RPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVF 460 EYEWD V+ ++E+Q RPE+EA C H +N +T+E E + + L + V Sbjct 409 EYEWDLVDFEEEQQQLQLRPEFEAMCKHRKLNAVTKEMEP-YMPLYTRIPWYFLSGATVT 467 Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIII 520 W+ L++ S++ +IVYRLSVF F++ + + + ++ +LTPQ TS+T S ++FI+I Sbjct 468 LWMSLVVTSMVAVIVYRLSVFATFASFMESDAS-LKQVKSFLTPQITTSLTGSCLNFIVI 526 Query 521 MILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 580 +ILN YEK++ IT E+PRT +YE+SLT+KMFLFQFVN+YSSCFY+AFFKGKFVGYP Sbjct 527 LILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYP 586 Query 581 GDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVS 640 G Y ++R+EECDPGGCL+ELTTQLTIIM GK I+ NI+E + P +N R + Sbjct 587 GKYTYLFNEWRSEECDPGGCLIELTTQLTIIMTGKQIFGNIKEAIYPLALNWWRRRKART 646 Query 641 GSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIR 700 SEK+ RWEQD+ L+ G LGLFYEYLE + QFGFVTLFVASFPLAPLLAL+NNI+EIR Sbjct 647 NSEKLYSRWEQDHDLESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIR 706 Query 701 VDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFS 760 VDAWKLTTQ+RR V KA IG WQ I+ G+A+L+V TNA I+AFTSD+IPRLVYY+++S Sbjct 707 VDAWKLTTQYRRTVASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYS 766 Query 761 VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQE 820 + + M GY+NN+LS+F +ADF N + + D TCRYRD+RYPP + Sbjct 767 T-----NATQPMTGYVNNSLSVFLIADFPNHTAPSEKRDF---ITCRYRDYRYPPDDENK 818 Query 821 YKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHE 880 Y HN+ +WHV+AAK+ FIIVMEHV++ VKF +++ IPDV K +I+REK +T K+LH+ Sbjct 819 YFHNMQFWHVLAAKMTFIIVMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHD 878 Query 881 NHLKDMTKNMGV 892 L + +N+G+ Sbjct 879 FELNKLKENLGI 890 >sp|Q8C5H1|ANO4_MOUSE Anoctamin-4 OS=Mus musculus OX=10090 GN=Ano4 PE=1 SV=2 Length=955 Score = 1047 bits (2707), Expect = 0.0, Method: Composition-based stats. Identities = 398/927 (43%), Positives = 578/927 (62%), Gaps = 62/927 (7%) Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54 +++M+++V + +E E DDD + NL T D LE+ + E N Sbjct 51 IQEMAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SEDTSRLEAGGE----TVRERN 105 Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114 K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E Sbjct 106 -KSNGLYFRDGKCRIDYILVYR-----------KSNPQTEKREVFERNIRAEGLQMEKES 153 Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164 S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213 Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221 K + +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKY 273 Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279 + +K G+NRL+ +G Y+AAFPLH+ +R ++ + N R+LLY WA Y Sbjct 274 E--EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIKTHGAVNHRHLLYECWASWGVWY 331 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+C SKEVC Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHCQVSKEVC-- 389 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR Sbjct 390 -QATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448 Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457 +A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E KC R+ + AS Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFT-DKCSRLIVSAS 507 Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517 +FF I ++IA+V GI++YR+ F+A Q AT+ TA I+F Sbjct 508 GIFFMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINF 559 Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577 IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F Sbjct 560 CIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFT 619 Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GR 635 G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N + Sbjct 620 GHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRK 679 Query 636 FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693 + G+E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+ Sbjct 680 VRQEHGTERKINFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALL 739 Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753 NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRL Sbjct 740 NNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRL 799 Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYR 809 VY + + G+ M GY+N +LS+F+++DF+N+S+ CRYR Sbjct 800 VYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYR 859 Query 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 869 D+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++R Sbjct 860 DYRDPPHSLAPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRR 919 Query 870 EKYLTQKLLHENHLKDMTKNMGVIAER 896 EKYL Q++++E L+ + K + Sbjct 920 EKYLIQEMMYEAELERLQKERKERKKN 946 >sp|Q8BHY3|ANO1_MOUSE Anoctamin-1 OS=Mus musculus OX=10090 GN=Ano1 PE=1 SV=2 Length=960 Score = 1045 bits (2703), Expect = 0.0, Method: Composition-based stats. Identities = 356/960 (37%), Positives = 526/960 (55%), Gaps = 101/960 (11%) Query 19 DDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPD-----SLFFNDGQRRIDFVL 73 +D + + N+ + DLG L S+ + PD L+F DG+R++D++L Sbjct 13 EDRSVHIVNI--CAIEDLGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGKRKVDYIL 66 Query 74 VYE---------------------------------------DESRKETNKKGTNEKQRR 94 VY D E + +R Sbjct 67 VYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRF 126 Query 95 KRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNR 154 +R+ YE NL+ GL+LE + FVK+HAPW VLC AE + +K+P K + + Sbjct 127 RREEYEGNLLEAGLELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTK--KVYHI 184 Query 155 SSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPA 206 S G L VL I+P+ + + PF + + + F + DRD+FF+ Sbjct 185 SETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSK 244 Query 207 TRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERY 266 TRS IVY IL R GI L+ +G+Y AA+PLHD + + + N+R Sbjct 245 TRSTIVYEILKRT--TCTKAKYSMGITSLLANGVYSAAYPLHDGDYEGDNVEF---NDRK 299 Query 267 LLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLN 326 LLY EWA YK QP+DL+RKY+GEK+G+YFAWLG YTQML+ A++VGV FLYG Sbjct 300 LLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCAT 359 Query 327 QDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMG 386 D S E+C D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM Sbjct 360 VDENIPSMEMC--DQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMA 417 Query 387 VWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINEIT--QEEE 439 +W F+E WKR+Q L Y WD ++EE+ R EYEAR + + + +E + Sbjct 418 LWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETD 477 Query 440 RIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQ 499 ++ T + ++ F I + A V+G+I+YR+S + +N + ++ Sbjct 478 KVKLTWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALA------MNSSPSVR 531 Query 500 KYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQF 559 + + + TA II+ ++I++L+ +Y +A +T E+P+T+ +E LT K FL +F Sbjct 532 SNI--RVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKF 589 Query 560 VNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKA-IW 618 VN Y+ FY+AFFKG+FVG PGD VY +R EEC PGGCL+EL QL+IIM GK I Sbjct 590 VNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQ 649 Query 619 NNIQEVLLPWIMNLIG--RFHRVSGSE-----KITPRWEQDYHLQPMGKLGLFYEYLEMI 671 NN+ E+ +P + I + R S S+ K R+E D++L+P GL EY+EMI Sbjct 650 NNLFEIGIPKMKKFIRYLKLRRQSPSDREEYVKRKQRYEVDFNLEPFA--GLTPEYMEMI 707 Query 672 IQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGI 731 IQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K T+ RR V +A+DIG W I++G+ Sbjct 708 IQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGV 767 Query 732 AILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNK 791 LAV+ NA +I+FTSD IPRLVY + +S + TM G++N+TLS F V+DF+N Sbjct 768 GKLAVIINAFVISFTSDFIPRLVYLYMYS-------QNGTMHGFVNHTLSSFNVSDFQNG 820 Query 792 SKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKF 850 + N DLG CRY+D+R PP +Y + +W V+AA+LAF+IV ++++ + Sbjct 821 TAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSD 880 Query 851 FISYAIPDVSKRTKSKIQREKYLTQKL-LHENHLKDMTKNMGVIAERMIEAVDNNLRPKS 909 F+ + IPD+ K +I +EK L +L + E K + + E+ + NN P + Sbjct 881 FVDWVIPDIPKDISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTT 940 >sp|Q32M45|ANO4_HUMAN Anoctamin-4 OS=Homo sapiens OX=9606 GN=ANO4 PE=1 SV=1 Length=955 Score = 1039 bits (2686), Expect = 0.0, Method: Composition-based stats. Identities = 396/927 (43%), Positives = 575/927 (62%), Gaps = 62/927 (7%) Query 1 MKKMSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFN 54 +++M+++V + +E E DDD + NL T D LE+ + E N Sbjct 51 IQEMAKDVNILFDELEAVSSPCKDDDSLLHPGNLTST-SDDASRLEAGGE----TVPERN 105 Query 55 GKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATR 114 K + L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E Sbjct 106 -KSNGLYFRDGKCRIDYILVYR-----------KSNPQTEKREVFERNIRAEGLQMEKES 153 Query 115 SVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF---- 164 S+++ ++FVK+HAPWEVL YAE M++++P + P K S ++ F Sbjct 154 SLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWL 213 Query 165 -TKVLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY 221 K + +D+ + E + +TAPF + R++ F I +++ FFN ATRSRIV+ IL R+KY Sbjct 214 PKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKETFFNNATRSRIVHHILQRIKY 273 Query 222 QVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIY 279 + +K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA Y Sbjct 274 E--EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAENHRHLLYECWASWGVWY 331 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QPLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG D+ SKEVC Sbjct 332 KYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVTTLDHSQVSKEVC-- 389 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR Sbjct 390 -QATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRR 448 Query 400 QAELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCAS 457 +A + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E KC R+ + AS Sbjct 449 RAVIAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFT-DKCSRLIVSAS 507 Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517 +FF I ++IA+V GI++YR+ F+A Q AT+ TA I+F Sbjct 508 GIFFMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINF 559 Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577 IIM+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F Sbjct 560 CIIMLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFT 619 Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GR 635 G+PG + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N + Sbjct 620 GHPGAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRK 679 Query 636 FHRVSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693 + G E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+ Sbjct 680 VRQEHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALL 739 Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753 NNI+EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRL Sbjct 740 NNIIEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRL 799 Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYR 809 VY + + G+ M GY+N +LS+F+++DF+N+S+ CRYR Sbjct 800 VYAYKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYR 859 Query 810 DFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQR 869 D+R PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++R Sbjct 860 DYRDPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRR 919 Query 870 EKYLTQKLLHENHLKDMTKNMGVIAER 896 EKYL Q++++E L+ + K + Sbjct 920 EKYLIQEMMYEAELERLQKERKERKKN 946 >sp|A6QLE6|ANO4_BOVIN Anoctamin-4 OS=Bos taurus OX=9913 GN=ANO4 PE=2 SV=1 Length=920 Score = 1032 bits (2669), Expect = 0.0, Method: Composition-based stats. Identities = 398/924 (43%), Positives = 575/924 (62%), Gaps = 62/924 (7%) Query 4 MSRNVLLQMEEEE------DDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKP 57 ++++V + +E E DDD + NL T D LE+ + PE + N Sbjct 19 VAKDVNILFDELEAVNSPCKDDDSLLHPGNLTST-SDDASRLEAGGE-TVPEKNKLN--- 73 Query 58 DSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVL 117 L+F DG+ RID++LVY + Q KR+ +E N+ GLQ+E S++ Sbjct 74 -GLYFRDGKCRIDYILVYR-----------KSNPQMEKREVFERNIRAEGLQMEKESSLI 121 Query 118 DDKLVFVKVHAPWEVLCTYAEIMHIKLPLK------PNDLKNRSSAFGTLNWF-----TK 166 + ++FVK+HAPWEVL YAE M++++P + P K S ++ F K Sbjct 122 NSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYLPRRYKFMSRIDKQISRFRRWLPKK 181 Query 167 VLSVDESIIK--PEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVI 224 + +D+ + E + +TAPF + R++ F I ++D FFN ATRSRIV+ IL R+KY+ Sbjct 182 PMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKDTFFNNATRSRIVHHILQRIKYE-- 239 Query 225 NNVSKFGINRLVNSGIYKAAFPLHDCKFRRQS--EDPSCPNERYLLYREWAHPRSIYKKQ 282 +K G+NRL+ +G Y+AAFPLH+ +R ++ N R+LLY WA YK Q Sbjct 240 EGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHGAVNHRHLLYECWASWGVWYKYQ 299 Query 283 PLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIG 342 PLDL+R+Y+GEKIG+YFAWLG+YT ML AA +G+ FLYG + D+C SKEVC Sbjct 300 PLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVFLYGVITLDHCQVSKEVC---QA 356 Query 343 GKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAE 402 IIMCP CD+ CPF +L+ +C +K +FD+ T+ FAVFM VW T+FLEFWKRR+A Sbjct 357 TDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFAVFMAVWATVFLEFWKRRRAV 416 Query 403 LEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAVF 460 + Y+WD ++ ++EE+ RP++EA+ + +N I+ + E A KC R+ + AS +F Sbjct 417 IAYDWDLIDWEEEEEEIRPQFEAKYSKKERMNPISGKPEPYQAFA-DKCSRLIVSASGIF 475 Query 461 FWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIII 520 F I ++IA+V GI++YR+ F+A Q AT+ TA I+F II Sbjct 476 FMICVVIAAVFGIVIYRVVTVSTFAAF--------KWALIRNNSQVATTGTAVCINFCII 527 Query 521 MILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYP 580 M+LN +YEKVA+++TN E PRT++++ENS T+KMFLFQFVN SS FYIAFF G+F G+P Sbjct 528 MLLNVLYEKVALLLTNLEQPRTESEWENSFTLKMFLFQFVNLNSSTFYIAFFLGRFTGHP 587 Query 581 GDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI--GRFHR 638 G + + ++R EEC P GCL++L Q+ IIM K WNN E+ P I N + + Sbjct 588 GAYLRLINRWRLEECHPSGCLIDLCMQMGIIMVLKQTWNNFMELGYPLIQNWWTRRKVRQ 647 Query 639 VSGSEKIT--PRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNI 696 G E+ P+WE+DY+LQPM GLF EYLEMI+QFGF T+FVA+FPLAPLLAL+NNI Sbjct 648 EHGPERKISFPQWEKDYNLQPMNAYGLFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNI 707 Query 697 LEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYY 756 +EIR+DA+K TQ+RR + +A+DIG W I++GI IL+V+TNA +IA TSD IPRLVY Sbjct 708 IEIRLDAYKFVTQWRRPLASRAKDIGIWYGILEGIGILSVITNAFVIAITSDFIPRLVYA 767 Query 757 WSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGN---PYSDLGNHTTCRYRDFR 812 + + G+ M GY+N +LS+F+++DF+N+S+ CRYRD+R Sbjct 768 YKYGPCAGQGEAGQKCMVGYVNASLSVFRISDFENRSEPESDGSEFSGTPLKYCRYRDYR 827 Query 813 YPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872 PP Y + + +WHV+AA+LAFIIV EH+++ +K ISY IPD+ K + +++REKY Sbjct 828 DPPHSLVPYGYTLQFWHVLAARLAFIIVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKY 887 Query 873 LTQKLLHENHLKDMTKNMGVIAER 896 L Q++++E L+ + K + Sbjct 888 LIQEMMYEAELERLQKERKERKKN 911 >sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 PE=1 SV=1 Length=986 Score = 1028 bits (2659), Expect = 0.0, Method: Composition-based stats. Identities = 353/986 (36%), Positives = 525/986 (53%), Gaps = 128/986 (13%) Query 19 DDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPD-----SLFFNDGQRRIDFVL 73 +D + + N+ + D+G L S+ + PD L+F DG+R++D++L Sbjct 13 EDRSVHIINI--CAIEDIGYLPSEGTL----LNSLSVDPDAECKYGLYFRDGRRKVDYIL 66 Query 74 VYE---------------------------------------DESRKETNKKGTNEKQRR 94 VY D E + +R Sbjct 67 VYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRF 126 Query 95 KRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNR 154 +R+ YE NL+ GL+LE + FVK+HAPW VLC AE + +K+P K + + Sbjct 127 RREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTK--KMYHI 184 Query 155 SSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVDRDAFFNPA 206 + G L VL I+P+ + + PF + + + F + D+D+FF+ Sbjct 185 NETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSK 244 Query 207 TRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERY 266 TRS IVY IL R GI L+ +G+Y AA+PLHD + ++ + N+R Sbjct 245 TRSTIVYEILKRT--TCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEF---NDRK 299 Query 267 LLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLN 326 LLY EWA YK QP+DL+RKY+GEKIG+YFAWLG YTQML+ A++VG+ FLYG Sbjct 300 LLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCAT 359 Query 327 QDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMG 386 D S E+C D I MCP CD+ C +WK++ C +++ +FD+ T+ F+VFM Sbjct 360 MDENIPSMEMC--DQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMA 417 Query 387 VWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINEITQEEER- 440 +W F+E WKR+Q L Y WD ++EE+ R EYEAR + + ++ +E+ Sbjct 418 LWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKR 477 Query 441 ---------------------------IPFTAWGKCIRITLCASAVFFWILLIIASVIGI 473 + T + ++ F I + A V+G+ Sbjct 478 RHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGV 537 Query 474 IVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIM 533 I+YR+S+ + +N + ++ + + + TA II+ ++I++L+ +Y +A Sbjct 538 IIYRISMAAALA------MNSSPSVRSNI--RVTVTATAVIINLVVIILLDEVYGCIARW 589 Query 534 ITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNE 593 +T E+P+T+ +E L K FL +FVN Y+ FY+AFFKG+FVG PGD VY +R E Sbjct 590 LTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRME 649 Query 594 ECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIG--RFHRVSGSE-----KI 645 EC PGGCL+EL QL+IIM GK I NN+ E+ +P + LI + + S + K Sbjct 650 ECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKR 709 Query 646 TPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWK 705 R+E DY+L+P GL EY+EMIIQFGFVTLFVASFPLAPL AL+NNI+EIR+DA K Sbjct 710 KQRYEVDYNLEPFA--GLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKK 767 Query 706 LTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYG 765 T+ RR V +A+DIG W I++GI LAV+ NA +I+FTSD IPRLVY + +S Sbjct 768 FVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYS----- 822 Query 766 DHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTT-CRYRDFRYPPGHPQEYKHN 824 + TM G++N+TLS F V+DF+N + N DLG CRY+D+R PP +Y + Sbjct 823 --KNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDIS 880 Query 825 IYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKL-LHENHL 883 +W V+AA+LAF+IV ++++ + F+ + IPD+ K +I +EK L +L + E Sbjct 881 KDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQD 940 Query 884 KDMTKNMGVIAERMIEA-VDNNLRPK 908 K + ER + N+ K Sbjct 941 KQQLLETWMEKERQKDEPPCNHHNTK 966 >sp|Q9BYT9|ANO3_HUMAN Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 PE=1 SV=2 Length=981 Score = 990 bits (2559), Expect = 0.0, Method: Composition-based stats. Identities = 371/853 (43%), Positives = 524/853 (61%), Gaps = 58/853 (7%) Query 57 PDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV 116 F DG++RID++LVY Q KR +E NL GL LE ++ Sbjct 152 SSGPLFKDGKKRIDYILVYR-----------KTNIQYDKRNTFEKNLRAEGLMLEKEPAI 200 Query 117 LDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKN--RSSAFGTL--------NWFTK 166 ++F+K+H PW+ LC YAE ++I++P + RS + G + NW + Sbjct 201 ASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQ 260 Query 167 VLSVDESIIKP---EQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223 V + P E + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+ Sbjct 261 NPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319 Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR--QSEDPSCPNERYLLYREWAHPRSIYKK 281 N +SK GI +L+N+G Y AAFP H+ ++ + N R+LLY WA YK Sbjct 320 -NGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKH 378 Query 282 QPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDI 341 QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AA+VG+ F YG +N S+E+C Sbjct 379 QPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICK--- 435 Query 342 GGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQA 401 ++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++ Sbjct 436 ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRS 495 Query 402 ELEYEWDTVELQQEEQA-RPEYEARCTHVVI-NEITQEEERIPFTAWGKCIRITLCASAV 459 L Y WD +E ++EE+ RP++EA+ + I N IT + E + K R+ + S + Sbjct 496 ILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQ-PSSDKVTRLLVSVSGI 554 Query 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFII 519 FF I L+I +V G++VYRL V F++ N Q ATS A I+FII Sbjct 555 FFMISLVITAVFGVVVYRLVVMEQFAS-FKWNFIKQYW-------QFATSAAAVCINFII 606 Query 520 IMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGY 579 IM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+ Sbjct 607 IMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH 666 Query 580 PGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV 639 PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R Sbjct 667 PGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIK 726 Query 640 SG-SEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILE 698 G + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+E Sbjct 727 RGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIE 786 Query 699 IRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWS 758 IR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY + Sbjct 787 IRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK 846 Query 759 FSVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPP 815 + P +H + ++GY+NN+LS F +++ +G CRYRD+R PP Sbjct 847 YG--PCANHVEPSENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPP 894 Query 816 GHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQ 875 + Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPDV K +I+REKYL Q Sbjct 895 WSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQ 954 Query 876 KLLHENHLKDMTK 888 ++++E L+ + + Sbjct 955 EMMYEAELEHLQQ 967 >sp|A2AHL1|ANO3_MOUSE Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 Length=981 Score = 990 bits (2558), Expect = 0.0, Method: Composition-based stats. Identities = 368/853 (43%), Positives = 524/853 (61%), Gaps = 58/853 (7%) Query 57 PDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSV 116 L F DG++RID++LVY Q KR +E NL GL LE ++ Sbjct 152 SSGLLFKDGKKRIDYILVYR-----------KTNIQYDKRNTFEKNLRAEGLMLEKEPAI 200 Query 117 LDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLK----NRSSAF------GTLNWFTK 166 + ++F+K+H PW+ LC YAE ++I++P + N+S + W ++ Sbjct 201 ANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQ 260 Query 167 VLSVDESIIKPE---QEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQV 223 V + PE + +T PF + R++ F I ++D FF+ ATRSRIVY +L R KY+ Sbjct 261 NPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYE- 319 Query 224 INNVSKFGINRLVNSGIYKAAFPLHDCKFRR--QSEDPSCPNERYLLYREWAHPRSIYKK 281 N +SK GI +L+ +G Y AAFP H+ ++ + N R+LLY WA YK Sbjct 320 -NGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKH 378 Query 282 QPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDI 341 QPLDLIR Y+GEKIG+YFAWLG+YT ML+ AAVVG+ F YG + + S+E+C Sbjct 379 QPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICK--- 435 Query 342 GGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQA 401 ++ MCP CD+ C +LN +C +K +FD+ GT+ FA+FM +W T+FLEFWKRR++ Sbjct 436 ATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRS 495 Query 402 ELEYEWDTVELQQEEQA-RPEYEARCTHV-VINEITQEEERIPFTAWGKCIRITLCASAV 459 L Y WD +E ++EE+ RP++EA+ + VIN IT + E + K R+ + S + Sbjct 496 ILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQ-PSSDKVTRLLVSVSGI 554 Query 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFII 519 FF I L+I +V ++VYRL V F++ N Q ATS A I+FII Sbjct 555 FFMISLVITAVFAVVVYRLVVMEQFAS-FKWNFVKQHW-------QFATSGAAVCINFII 606 Query 520 IMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGY 579 IM+LN YEK+A ++TN E PRT++++ENS +KMFLFQFVN SS FYIAFF G+FVG+ Sbjct 607 IMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH 666 Query 580 PGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRV 639 PG ++R EEC P GCL++L Q+ +IM K IWNN E+ P I N R Sbjct 667 PGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIK 726 Query 640 SG-SEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILE 698 G + P+WE D++LQPM GL EYLEM++QFGF T+FVA+FPLAPLLAL+NNI+E Sbjct 727 RGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIE 786 Query 699 IRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWS 758 IR+DA+K TQ+RR +P +A DIG W I++GI ILAV+TNA +IA TSD IPR VY + Sbjct 787 IRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK 846 Query 759 FSVPPYGDH---TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPP 815 + P +H ++GY+NN+LS F +++ +G CRYRD+R PP Sbjct 847 YG--PCANHVKQNENCLKGYVNNSLSFFDLSEL----------GMGKSGYCRYRDYRGPP 894 Query 816 GHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQ 875 + Y+ + YWH++AA+LAFIIV EH+++ +K FI+Y IPD+ K + +I+REKYL Q Sbjct 895 WSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQ 954 Query 876 KLLHENHLKDMTK 888 ++++E L+ + + Sbjct 955 EMMYEAELEHLQQ 967 >sp|Q9NQ90|ANO2_HUMAN Anoctamin-2 OS=Homo sapiens OX=9606 GN=ANO2 PE=1 SV=2 Length=1003 Score = 988 bits (2555), Expect = 0.0, Method: Composition-based stats. Identities = 327/903 (36%), Positives = 484/903 (54%), Gaps = 97/903 (11%) Query 52 EFNGKPDSLFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTN 89 + + F+D QR++D+VL Y E+ KE + G Sbjct 82 SLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPG 141 Query 90 EKQRRKRQAYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAE 138 + + A E NL+ GL+LE +FV++HAPW+VL AE Sbjct 142 DIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAE 201 Query 139 IMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNR 190 + IK+P K ++ + F+ L S ++P + + + PF + + Sbjct 202 FLKIKVPTK-KEMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREK 260 Query 191 MNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDC 250 M + I ++D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD Sbjct 261 MYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDG 318 Query 251 KFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLL 310 ++ +D N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ Sbjct 319 EYDSPEDDM---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLI 375 Query 311 LAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKL 370 ++V+GV FLYG + S+E+C D MCP CD+ C +W L+ C +++ Sbjct 376 PSSVIGVIVFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQAS 433 Query 371 CIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEAR 425 +FD+ T+ F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + Sbjct 434 HLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETK 493 Query 426 CTHVVINEITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASV 470 ++ E Q E++ T + + +++ F I L + V Sbjct 494 VREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIV 553 Query 471 IGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKV 530 G+IVYR++ S N + + TA II+ ++I+IL+ IY V Sbjct 554 FGVIVYRITTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAV 603 Query 531 AIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKY 590 A +T E+P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY Y Sbjct 604 AKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGY 663 Query 591 RNEECDPGGCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSG-------S 642 R EEC PGGCL+EL QL+IIM GK I NNI E+ +P + L + + Sbjct 664 RMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAH 723 Query 643 EKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVD 702 K +W+ DY L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+D Sbjct 724 SKHPEQWDLDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLD 781 Query 703 AWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVP 762 A K T+ RR + +DIG W I+ GI +V++NA +IA TSD IPRLVY +S+S Sbjct 782 AKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS-- 839 Query 763 PYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYK 822 + T+ G++N+TLS F V+ K ++ CR++D+R PP P Y+ Sbjct 840 -----HNGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYE 894 Query 823 HNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHEN 881 + YW +++A+LAF+I+ ++++ + + + IPD+ +I++EK L L E Sbjct 895 FSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEE 954 Query 882 HLK 884 H K Sbjct 955 HEK 957 >sp|Q8CFW1|ANO2_MOUSE Anoctamin-2 OS=Mus musculus OX=10090 GN=Ano2 PE=1 SV=2 Length=1002 Score = 982 bits (2539), Expect = 0.0, Method: Composition-based stats. Identities = 329/894 (37%), Positives = 482/894 (54%), Gaps = 97/894 (11%) Query 60 LFFNDGQRRIDFVLVYE----------------------DESRKETNKKGTNEKQRRKRQ 97 + F+D QR++D+VL Y E+ KE + G + + Sbjct 90 MHFHDNQRKVDYVLAYHYRKRGAHLGHGSPGHSLAVISNGETGKERHGGGPGDVELGPLD 149 Query 98 AYES-----------NLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146 A E NL+ GL+LE VFV++HAPW+VL AE + IK+P Sbjct 150 ALEEERREQRDEFEHNLMAAGLELEKDLESKSQGSVFVRIHAPWQVLAREAEFLKIKVPT 209 Query 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKPE--------QEFFTAPFEKNRMNDFYIVD 198 K + + F+ +L S ++P + + PF + +M + I + Sbjct 210 K--KMYEIKAGGSIAKKFSAILQTLSSPLQPRVPEHSNNRMKNLSYPFSREKMYLYNIQE 267 Query 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258 +D FF+ ATRSRIV+ IL R NN GIN L+ + IY+AA+PLHD ++ +D Sbjct 268 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPGDD 325 Query 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318 N+R LLY+EWA YK QP+DLIRKY+GEKIG+YFAWLG YT L+ ++V+GV Sbjct 326 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 382 Query 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378 FLYG + SKE+C D MCP CD+ C +W L+ C +++ +FD+ T Sbjct 383 VFLYGCATIEEDIPSKEMC--DHQNAFTMCPLCDKSCDYWNLSSACGTARASHLFDNPAT 440 Query 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVEL-----QQEEQARPEYEARCTHVVINE 433 + F++FM +W T+FLE WKR Q L Y WD + + +E +RPEYE + ++ E Sbjct 441 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERSQEHSRPEYETKVREKLLKE 500 Query 434 -----ITQEEERIP---------FTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479 + + E P T + + +++ F I L + V G+IVYR++ Sbjct 501 SGKSAVQKLEANSPEDDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT 560 Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539 S N + + TA II+ ++I+IL+ IY VA +T E+ Sbjct 561 TAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEV 610 Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599 P+T+ +E L +K FL +FVN YS FY+AFFKG+FVG PG VY YR EEC PGG Sbjct 611 PKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGG 670 Query 600 CLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRFHRVSGSEKITP-------RWEQ 651 CL+EL QL+IIM GK I NNI E+ +P + L + + + P +W+ Sbjct 671 CLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEPGESDPDHSKRPEQWDL 730 Query 652 DYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFR 711 D+ L+P GL EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K T+ R Sbjct 731 DHSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELR 788 Query 712 RLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYT 771 R + +DIG W I+ GI +V+ NA +IA TSD IPRLVY +S+S + T Sbjct 789 RPDAVRTKDIGIWFDILSGIGKFSVIINAFVIAVTSDFIPRLVYQYSYS-------HNGT 841 Query 772 MEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVI 831 + G++N+TLS F V+ K ++ CR++D+R PP P Y+ + YW V+ Sbjct 842 LHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWSVL 901 Query 832 AAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884 +A+LAF+I+ ++++ + + + IPD+ +I++EK L L E H K Sbjct 902 SARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 955 >sp|Q14AT5|ANO7_MOUSE Anoctamin-7 OS=Mus musculus OX=10090 GN=Ano7 PE=1 SV=2 Length=859 Score = 958 bits (2476), Expect = 0.0, Method: Composition-based stats. Identities = 315/841 (37%), Positives = 478/841 (57%), Gaps = 59/841 (7%) Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125 IDFVLV+E++ R +E K + R+ + NL GL+++ V D+ ++ Sbjct 55 IDFVLVWEEDLRNQENPTKDKTDTHEVWRETFLENLCLAGLKID-QHDVQDEAAAVHYIL 113 Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183 + APW VLC YAE + +KLPL+ PN N S+ L W + E + E+++ Sbjct 114 LRAPWAVLCYYAEDLRLKLPLQELPNQASNWSAT--LLEWLGIPNILLEHVPDTPPEYYS 171 Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242 F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++ Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKGLFGIDQLLAEGVFS 230 Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA Sbjct 231 AAFPLHDGPFSAVPESSQVLGLIQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFA 290 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L Sbjct 291 WLGFYTGWLLPAAVVGTVVFLVGCFLVFSDIPTQELCHSS--DSFDMCPLCSD-CSFWLL 347 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419 + C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478 P++ A +N IT E+E P+ +R L S V ++ + I ++ +I+YR Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSVILYRA 465 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 + I+ S +D S+T S+++ + I+IL+ +Y +A ++T +E Sbjct 466 VMAIIVS--------RSDNAFLSAWASRIASLTGSVVNLVFILILSKVYVLLAQVLTRWE 517 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 + RTQT++E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ G RNEEC G Sbjct 518 MHRTQTEFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFG-IRNEECPAG 576 Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHR--VSGSEKITPRWEQDYHLQ 656 GCL EL +L +IM GK I NN+QEVL+P + +F R +G+ WE DY L Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKFSRGKKAGTGTHPAPWEADYELL 636 Query 657 PMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPE 716 P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V E Sbjct 637 PCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAE 694 Query 717 KAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYI 776 +AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G++ Sbjct 695 RAQDIGIWFHILTGLTHLAVISNAFLLAFSSDFLPRVYYSWTHAP---------DLHGFL 745 Query 777 NNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLA 836 N TL+ + P ++ TCRYR FR GH ++ YW ++A +LA Sbjct 746 NFTLA-----------RAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRLA 789 Query 837 FIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAER 896 F+IV EHV++S+ + +PD+ + + K++RE YL ++ L EN + GV ++ Sbjct 790 FVIVFEHVVFSIGRVLDLLVPDIPESVEIKVKREYYLAKQALAENE--ALLGATGVKDDQ 847 Query 897 M 897 Sbjct 848 P 848 >sp|Q6IFT6|ANO7_RAT Anoctamin-7 OS=Rattus norvegicus OX=10116 GN=Ano7 PE=2 SV=1 Length=860 Score = 956 bits (2470), Expect = 0.0, Method: Composition-based stats. Identities = 314/842 (37%), Positives = 477/842 (57%), Gaps = 60/842 (7%) Query 69 IDFVLVYEDESR-KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV--FVK 125 IDFVLV+E++ R +E + + R+ + NL GL+++ R V D+ ++ Sbjct 55 IDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKID-QRDVQDEAAAVHYIL 113 Query 126 VHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFT 183 + APW VLC YAE + +KLPL+ PN N S+ L W + E++ E+++ Sbjct 114 LSAPWAVLCYYAEDLRLKLPLQELPNQASNWSAT--LLEWLGIPNILLENVPDTPPEYYS 171 Query 184 APFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYK 242 F+ +++ F D +D FF R +I++ IL++ Y FGI++L+ G++ Sbjct 172 CQFKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-QKKGLFGIDQLLAEGVFS 230 Query 243 AAFPLHDCKFRRQSEDPSCPN--ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA 300 AAFPLHD F E +R +L++ WA K QPLD +R+Y+GEK+ +YFA Sbjct 231 AAFPLHDGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFA 290 Query 301 WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL 360 WLG+YT LL AAVVG FL G + ++E+CH MCP C C FW L Sbjct 291 WLGFYTGWLLPAAVVGTVVFLAGCFLVFSDVPTQELCHSS--DTFDMCPLCSD-CSFWLL 347 Query 361 NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-EEQAR 419 + C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + EE+ R Sbjct 348 SSACTLAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPR 407 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLI-IASVIGIIVYRL 478 P++ A +N IT E+E P+ +R L S V ++ + I ++ II+YR Sbjct 408 PQFAATAPMTALNPITGEDE--PYFPEKNRVRRMLAGSVVLLMMVAVVIMCLVSIILYRA 465 Query 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538 + I+ S ++ S+T S+++ + I+IL+ +Y +A ++T +E Sbjct 466 VMAIIVS--------KSNNAFLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTRWE 517 Query 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598 + RTQT +E++ T+K+F+FQFVN+Y+S YIAFFKG+FVGYPG+ G RNEEC G Sbjct 518 MHRTQTAFEDAFTLKVFIFQFVNFYASPVYIAFFKGRFVGYPGNYHTLFG-VRNEECPAG 576 Query 599 GCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGR---FHRVSGSEKITPRWEQDYHL 655 GCL EL +L +IM GK I NN+QEVL+P + + + +G WE DY L Sbjct 577 GCLSELAQELLVIMVGKQIINNVQEVLVPKLKGCWQKLCSRRKKAGMGANPAPWEADYEL 636 Query 656 QPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVP 715 P GLF+EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K ++RR V Sbjct 637 LPCE--GLFHEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVA 694 Query 716 EKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGY 775 E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR+ Y W+ + + G+ Sbjct 695 ERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRVYYSWT---------RAPDLRGF 745 Query 776 INNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKL 835 +N TL+ + P ++ TCRYR FR GH ++ YW ++A +L Sbjct 746 LNFTLA-----------RAPPTFTSAHNRTCRYRAFRDDDGH-----YSPTYWTLLAIRL 789 Query 836 AFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAE 895 AF+IV EHV++S F+ +PD+ + + K++RE YL ++ L +N + GV E Sbjct 790 AFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNE--ALLGATGVKGE 847 Query 896 RM 897 + Sbjct 848 QP 849 >sp|Q6IWH7|ANO7_HUMAN Anoctamin-7 OS=Homo sapiens OX=9606 GN=ANO7 PE=1 SV=2 Length=933 Score = 944 bits (2440), Expect = 0.0, Method: Composition-based stats. Identities = 314/858 (37%), Positives = 477/858 (56%), Gaps = 65/858 (8%) Query 67 RRIDFVLVYEDESR----KETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLV 122 R DFVLV+E++ + +++ + + R R+ + NL GL ++ + V D Sbjct 108 RIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVD-QQDVQDGNTT 166 Query 123 --FVKVHAPWEVLCTYAEIMHIKLPLK--PNDLKNRSSAFGTLNWFTKVLSVDESIIKPE 178 + + A W VLC YAE + +KLPL+ PN N S+ G L W + E + Sbjct 167 VHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSA--GLLAWLGIPNVLLEVVPDVP 224 Query 179 QEFFTAPFEKNRMNDFYIVD-RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVN 237 E+++ F N++ F D +D FF R +I++ IL++ Y + GI++L+ Sbjct 225 PEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGH-EKKNLLGIHQLLA 283 Query 238 SGIYKAAFPLHDCKFRRQSEDPSCP--NERYLLYREWAHPRSIYKKQPLDLIRKYYGEKI 295 G+ AAFPLHD F+ E P P N+R +L++ WA K QPLD +R+Y+GEK+ Sbjct 284 EGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKV 343 Query 296 GIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLC 355 +YFAWLG+YT LL AAVVG FL G + ++E+C MCP C C Sbjct 344 ALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGS--KDSFEMCPLCLD-C 400 Query 356 PFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ- 414 PFW L+ C ++ +FD GT+ F++FM +W L LE+WKR+ A L Y WD + + Sbjct 401 PFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDT 460 Query 415 EEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGII 474 EE+ RP++ A N IT E+E F + R+ + + + +++ ++ II Sbjct 461 EERPRPQFAASAPMTAPNPITGEDEP-YFPERSRARRMLAGSVVIVVMVAVVVMCLVSII 519 Query 475 VYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMI 534 +YR + IV S + S+T S+++ + I+IL+ IY +A ++ Sbjct 520 LYRAIMAIVVS--------RSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVL 571 Query 535 TNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEE 594 T +E+ RTQT +E++ T+K+F+FQFVN+YSS YIAFFKG+FVGYPG+ G RNEE Sbjct 572 TRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFG-VRNEE 630 Query 595 CDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITP------- 647 C GGCL+EL +L +IM GK + NN+QEVL+P + +F S K Sbjct 631 CAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQG 690 Query 648 RWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLT 707 WE DY L P GLF EYLEM++QFGFVT+FVA+ PLAPL AL+NN +EIR+DA K Sbjct 691 PWEDDYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFV 748 Query 708 TQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDH 767 ++RR V E+AQDIG W I+ G+ LAV++NA ++AF+SD +PR Y W+ Sbjct 749 CEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWT--------- 799 Query 768 TSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYY 827 ++ + G++N TL+ + ++ TCRYR FR GH ++ Y Sbjct 800 RAHDLRGFLNFTLA-----------RAPSSFAAAHNRTCRYRAFRDDDGH-----YSQTY 843 Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMT 887 W+++A +LAF+IV EHV++SV + +PD+ + + K++RE YL ++ L EN + + Sbjct 844 WNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEV--LF 901 Query 888 KNMGVIAERMIEAVDNNL 905 G E+ + ++ Sbjct 902 GTNGTKDEQPEGSELSSH 919 >sp|A1A5B4|ANO9_HUMAN Anoctamin-9 OS=Homo sapiens OX=9606 GN=ANO9 PE=1 SV=3 Length=782 Score = 727 bits (1876), Expect = 0.0, Method: Composition-based stats. Identities = 266/849 (31%), Positives = 428/849 (50%), Gaps = 113/849 (13%) Query 40 ESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAY 99 ES PE + F S + + D+VLV + +++ + ++ ++Q + Sbjct 5 ESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQR--------DPRQARQQQF 56 Query 100 ESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFG 159 L G ++ + D K VF + A V Y Sbjct 57 LEELRRKGFHIKV---IRDQKQVFFGIRADNSVFGLY----------------------- 90 Query 160 TLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRV 219 + L ++ P E AP + R RIV F+ Sbjct 91 ------RTLLLEPEGPAPHAE-LAAPTTIP-------------VTTSLRIRIVNFV---- 126 Query 220 KYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRS 277 V+NN + G L+ G+++A FPLH + R L + WA R Sbjct 127 ---VMNNKTSAGETFEDLMKDGVFEARFPLHKGEGR--------------LKKTWARWRH 169 Query 278 IYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVC 337 ++++QP+D IR Y+GEK+ +YF WLG+YT ML+ AA+ G+ FL G+ + SKE+C Sbjct 170 MFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEIC 229 Query 338 HPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWK 397 I+MCP D + +L+ TC +K +FD+ GT+VFA+FM +W T+FLE WK Sbjct 230 E---AHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWK 286 Query 398 RRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCAS 457 R++A + WD +E++ C + +R T+ Sbjct 287 RQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQ-----------HSYLRSTVILV 335 Query 458 AVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISF 517 I L+I ++VYR+ +FS+ + +++ +T TA +T +++ + Sbjct 336 LTLLMICLMIGMAHVLVVYRVLASALFSS------SAVPFLEEQVT--TAVVVTGALVHY 387 Query 518 IIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFV 577 + I+I+ I VA+ + +FE+PRT ++ E+ T++ F QF ++SS YIAF G+ Sbjct 388 VTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRIN 447 Query 578 GYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFH 637 G+PG G ++ EEC GC+++L Q+ IIMG K +N E L+PW+ + Sbjct 448 GHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLR 507 Query 638 R-VSGSEKITPR---WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALV 693 SG P W ++Y L P+ LF E++EM+IQ+GF T+FVA+FPLAPLLAL Sbjct 508 ASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALF 567 Query 694 NNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRL 753 +N++EIR+DA K+ RRLVP KA+DIG W +++ I +LAV+ N M+IAFTS+ IPR+ Sbjct 568 SNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRV 627 Query 754 VYYWSFS-VPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFR 812 VY + +S G+ T ++GY+N++LS+F DF++ + N T CRYRD+R Sbjct 628 VYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQD---PDGIEGSENVTLCRYRDYR 684 Query 813 YPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872 PP +Y + +W ++A +LAF+I+ EHV +K ++ +PD+ + K+K+ KY Sbjct 685 NPP----DYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKY 740 Query 873 --LTQKLLH 879 L +K+ H Sbjct 741 QRLREKMWH 749 >sp|P86044|ANO9_MOUSE Anoctamin-9 OS=Mus musculus OX=10090 GN=Ano9 PE=1 SV=1 Length=747 Score = 686 bits (1771), Expect = 0.0, Method: Composition-based stats. Identities = 229/692 (33%), Positives = 367/692 (53%), Gaps = 82/692 (12%) Query 198 DRDAFFNPATRSRIVYFILSRVKYQVINNVSKFG--INRLVNSGIYKAAFPLHDCKFRRQ 255 D +F TR RIV F+ +NN K G LV G+++ F LH + Sbjct 105 DEQSFNIATTRIRIVSFV--------VNNKLKPGDTFEDLVKDGVFETMFLLHKGEQN-- 154 Query 256 SEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVV 315 L WA R++++ QP+D IR+Y+GEK+ +YF WLG+YT ML+ AAVV Sbjct 155 ------------LKNIWARWRNMFEPQPIDEIREYFGEKVALYFTWLGWYTYMLVPAAVV 202 Query 316 GVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDS 375 G+ FL G+ D+ SKE+C I MCP D + +L+ C +K +FD+ Sbjct 203 GLIVFLSGFALFDSSQISKEICS---ANDIFMCPLGDHSHRYLRLSEMCTFAKLTHLFDN 259 Query 376 FGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQ-------EEQARPEYEARCTH 428 GT++FA+FM +W T+FLE WKR++A W E + E P Y+ + Sbjct 260 EGTVLFAIFMALWATVFLEIWKRKRAHEVQSWKLYEWDEEEEEMALELINSPHYKLK--- 316 Query 429 VVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKL 488 + R + + + ++L F I L+I ++VYR+ +FS+ + Sbjct 317 ---------DHRHSYLSSTIILILSL------FMICLMIGMAHVLVVYRVLAGALFSSLV 361 Query 489 PKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYEN 548 + + + + +III+I+ + + VA+ + FE T ++ E Sbjct 362 KQQVTTAVVVTGAVV------------HYIIIVIMTKVNKYVALKLCKFEESGTFSEQER 409 Query 549 SLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQL 608 T+K F+ QF ++SS YIAF G+ G+PG G ++ EEC GC+++L Q+ Sbjct 410 KFTVKFFILQFFAHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHLSGCMMDLFIQM 469 Query 609 TIIMGGKAIWNNIQEVLLP-----WIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL 663 IIMG K +N E L P W + + +S ++ W+++Y++ P+ L Sbjct 470 AIIMGLKQTLSNCVEYLCPLLAHKWRLMWASKHGHMSKDPELK-EWQRNYYMNPINTFSL 528 Query 664 FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGA 723 F E++EM+IQ+GF T+FVA+FPLAPLLAL +N++EIR+DA K+ RRLVP KA+DIG Sbjct 529 FDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVRLQRRLVPRKAKDIGT 588 Query 724 WQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTS---YTMEGYINNTL 780 W +++ I +LAV+ N M+IAFTS+ IPR+VY + + P + + + Y+N++L Sbjct 589 WLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYHYG--PCRTNRTFTDDCLTNYVNHSL 646 Query 781 SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV 840 S+F F + S+ N T CRYRD+R +Y + +W ++A +L F+I+ Sbjct 647 SVFYTKHFNDHSRMEGQE---NVTVCRYRDYRN----EHDYNLSEQFWFILAIRLTFVIL 699 Query 841 MEHVIYSVKFFISYAIPDVSKRTKSKIQREKY 872 EH +K ++ +PDV ++ K+++ +EKY Sbjct 700 FEHFALCIKLIAAWFVPDVPQKVKNEVLQEKY 731 >sp|Q9NW15|ANO10_HUMAN Anoctamin-10 OS=Homo sapiens OX=9606 GN=ANO10 PE=1 SV=2 Length=660 Score = 422 bits (1085), Expect = 3e-135, Method: Composition-based stats. Identities = 149/594 (25%), Positives = 251/594 (42%), Gaps = 121/594 (20%) Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222 + + FT + F + D F A I+ L ++ Sbjct 88 LVKECNDNTMRAFTYR-TRQNFKGFDDNNDD-FLTMAECQFIIKHELENLRAKDEKMIPG 145 Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279 G + RL+ SGI FPLHD + ++ ED W + R Sbjct 146 YPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDT------------W-YTRFAL 192 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QP+D IR Y+GE I +YF +L Y+T L+ AV+G+ +L+ + + D Sbjct 193 KYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDK---------- 242 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 ++FA F +W T+ LE WKR Sbjct 243 --------------------------------------YVIFASFNLIWSTVILELWKRG 264 Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458 A + Y W T+ ++++ E+ RP + IN IT +EE + + ++ + +RI L S Sbjct 265 CANMTYRWGTLLMKRKFEEPRPGFHGVLG---INSITGKEEPL-YPSYKRQLRIYLV-SL 319 Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518 F + L + + +I + + V+ + +G++ L SII I Sbjct 320 PFVCLCLYFSLYVMMIYFDMEVWALGLH----ENSGSEWTSVLL-------YVPSIIYAI 368 Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578 +I I+N +Y A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF Sbjct 369 VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD--- 425 Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----I 633 + L L ++ I N I E LP+ + + Sbjct 426 ----------------------MKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRV 463 Query 634 GRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLAL 692 R + ++ +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A+ Sbjct 464 KRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV 523 Query 693 VNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 +NN E+ DA K+ F+R E + +IG WQ + +++++VVTN +I + Sbjct 524 LNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577 Score = 38.6 bits (88), Expect = 0.34, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 35/53 (66%), Gaps = 0/53 (0%) Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890 ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K +T+N+ Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENL 647 >sp|Q8BH79|ANO10_MOUSE Anoctamin-10 OS=Mus musculus OX=10090 GN=Ano10 PE=1 SV=1 Length=659 Score = 421 bits (1082), Expect = 7e-135, Method: Composition-based stats. Identities = 147/594 (25%), Positives = 253/594 (43%), Gaps = 121/594 (20%) Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222 + + FT ++ F+ + D F A I+ L ++ Sbjct 88 LVKECTDAAMRAFTYG-TRHNFKGFHDNNND-FLTMAECQFIIKHELENLRARDEKMIPG 145 Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279 G + RL+ SGI FPLHD + ++ ED W + R Sbjct 146 YPQAKLYPGKSLMRRLLTSGIVTQVFPLHDTEALKKLEDT------------W-YTRFAL 192 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 K QP+D IR Y+GE I +YF +L Y+T L+ A++G+ +L+ + + D Sbjct 193 KYQPIDSIRSYFGETIALYFGFLEYFTFALIPMAIIGLPYYLFVWEDYDK---------- 242 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 ++FA F +W T+ LE WKR Sbjct 243 --------------------------------------YVIFASFNLIWSTVILEVWKRG 264 Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458 A + Y W T+ ++++ E+ RP + IN +T EE + ++++ + +RI L S Sbjct 265 CANMTYRWGTLVMKRQFEEPRPGFHGVLG---INSVTGREEPL-YSSYKRQLRIYLV-SL 319 Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518 F + L + + +I + + + + +G++ L SI+ + Sbjct 320 PFVCLCLYFSLYVMMIYFDMEDWALSLH----EDSGSEWTSLLL-------YVPSIVYAV 368 Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578 +I I+N +Y A +T++E R ++ Y+N L +K+ +F F+N ++S FYIAF Sbjct 369 VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKD--- 425 Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL-----I 633 + L L ++ I N + E LLP+ + + Sbjct 426 ----------------------MKLLRQSLATLLITSQILNQVVESLLPYWLQRKYCARV 463 Query 634 GRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLAL 692 R + SE T +EQ + MG LG F +YLE+ +QFG+V+LF +PLA A+ Sbjct 464 KRKVQALKSEVDTTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV 523 Query 693 VNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 +NN E+ DA K+ F+R E + IG WQ + +++++VVTN +I + Sbjct 524 LNNFTEVNSDALKMCRVFKRPFAEPSASIGVWQLAFETMSVISVVTNCALIGMS 577 Score = 38.6 bits (88), Expect = 0.29, Method: Composition-based stats. Identities = 13/53 (25%), Positives = 34/53 (64%), Gaps = 0/53 (0%) Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNM 890 ++ +EH + ++KF +++AIPD + + K+ R ++ + + L + +K + +N+ Sbjct 595 VVAVEHALLALKFILAFAIPDKPRHIQQKLARLEFESLEALKQQQMKLVAENL 647 >sp|Q4V8U5|ANO10_DANRE Anoctamin-10 OS=Danio rerio OX=7955 GN=ano10 PE=2 SV=1 Length=646 Score = 390 bits (1002), Expect = 3e-123, Method: Composition-based stats. Identities = 149/595 (25%), Positives = 247/595 (42%), Gaps = 123/595 (21%) Query 170 VDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKY-------Q 222 + + FT + DF D + F A IV L ++ Sbjct 88 LFKEFQDGTMRGFTYA-NRESFKDFEG-DGEGFLGDAECQYIVKHELDTLRAKNEEYIPG 145 Query 223 VINNVSKFG---INRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIY 279 G + RL + G+ FPLH+ + + L W + + Sbjct 146 YPKYKLYPGKSIVRRLQSKGVLVQYFPLHNKE------------DLKRLSFSW-YKKIKL 192 Query 280 KKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHP 339 QPLD IR Y+GE +G+YF +L Y+T L+ A++G+ +L+ + + D Sbjct 193 SFQPLDDIRSYFGEGLGLYFGFLEYFTFALIPMALIGIPYYLFDWEDYDK---------- 242 Query 340 DIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRR 399 ++FAVF VW T+FLE WKR Sbjct 243 --------------------------------------YVLFAVFNLVWSTVFLEVWKRC 264 Query 400 QAELEYEWDTVELQQE-EQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASA 458 A L Y W T+ ++ E+ R + +N +T EE I + + + +RI L + Sbjct 265 SATLAYSWGTLGRKKAFEEPRAGFHGPLG---LNPVTGREEPI-YPSSKRHLRIYLVSVP 320 Query 459 VFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFI 518 F + L ++ + ++ + + + + + +N N + + SII + Sbjct 321 -FVLLCLYLSFYVMMVYFDMEFWAI--SIYHENPNFATSVLLF---------VPSIIYAV 368 Query 519 IIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG 578 +I I+N +Y A +T++E R ++ ++N L K+ +F FVN ++S FYIAF V Sbjct 369 VIEIMNLLYRYAAEFLTDWENHRLESSFQNHLVPKVLVFNFVNCFASLFYIAFVMQDMV- 427 Query 579 YPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNL------ 632 L L ++ I N + E LP+ + Sbjct 428 ------------------------LLRQSLATLLITSQILNQVMEAFLPYWLQRRRNKRV 463 Query 633 IGRFHRVSGSEKITPRWEQDYHLQPMGK-LGLFYEYLEMIIQFGFVTLFVASFPLAPLLA 691 R R+ G +++ P EQ M LG F +YLE + FG+V+LF PLA +L Sbjct 464 YKRMRRLMGDKEL-PLLEQIQLETEMNTYLGTFDDYLEQFLLFGYVSLFSCVHPLAAVLV 522 Query 692 LVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFT 746 ++NNI E+ DA+K+ F+R E A +IG WQ + ++I+AVVTN +IA + Sbjct 523 VLNNITEVYSDAFKMCHVFKRPFSEPAANIGVWQLAFETMSIIAVVTNCALIALS 577 Score = 36.7 bits (83), Expect = 1.1, Method: Composition-based stats. Identities = 12/43 (28%), Positives = 27/43 (63%), Gaps = 0/43 (0%) Query 838 IIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHE 880 ++ +EHV+ + KF +++ IPDV K + K+ + + + + L + Sbjct 595 VVAIEHVLLAFKFILAFVIPDVPKHIQVKLSKLDFESLEALKK 637 >sp|Q0JJZ6|CACLC_ORYSJ Anoctamin-like protein Os01g0706700 OS=Oryza sativa subsp. japonica OX=39947 GN=Os01g0706700 PE=2 SV=1 Length=665 Score = 376 bits (965), Expect = 1e-117, Method: Composition-based stats. Identities = 142/673 (21%), Positives = 237/673 (35%), Gaps = 151/673 (22%) Query 101 SNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGT 160 L GL +E R V + F+K+ AP L A M++K Sbjct 49 RELEDVGLIVERVRGVPAE---FIKLSAPMGTLGRVAAEMNMK-----KLTYIGMELQFE 100 Query 161 LNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVK 220 + + + + +E F F + D D + + + Sbjct 101 WDQVGAFVRQPDGSLFSWRERFAC-FRHLIYSIVNKTDSDITLSFDDKE---FHWTQNES 156 Query 221 YQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYK 280 + RL + GI K FPLHD R+Q L R WA + Sbjct 157 L----------LTRLEDEGIVKLVFPLHDEIKRKQ------------LLRSWALKWFDFT 194 Query 281 KQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPD 340 QP+D I Y+G KI IYF++LG YT+ L AV G+ Sbjct 195 WQPIDEIYSYFGTKIAIYFSFLGMYTRWLFFPAVFGL----------------------- 231 Query 341 IGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLV---FAVFMGVWVTLFLEFWK 397 + +L F S LV F F+ W FL+FWK Sbjct 232 --------------------------ATQLIDFGSLQWLVLPAFFFFVISWAVFFLQFWK 265 Query 398 RRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCAS 457 R+ + + W + EY+ + + ++ + +G ++ Sbjct 266 RKNSAVLARWGI------NYSFSEYKTMGNELDPLSFSMADDNVQQRKFGAPKEKSIVQR 319 Query 458 AVFFWILLIIA----SVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513 +F +LL I V+ II +L + ++ I T+ ++ LT Sbjct 320 NEWFGVLLRIRNNAIIVLAIICLQLPFELAYAHLYA--ITKTEALRYVLTA--------- 368 Query 514 IISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFK 573 + I I KV++ + +E + + +SL K+F F+ Y FY A Sbjct 369 -VYLAAIQYYTRIGGKVSVTLIKYENNQGEQSSADSLVYKVFGLYFMQSYIGLFYHASLH 427 Query 574 GKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLI 633 ++ L L + + N+ E +P++ Sbjct 428 RN-------------------------IMALRQVLIKRLIVSQVLENLIENSIPYLNYSY 462 Query 634 GRFHRV-----------SGSEKITPRWEQDYHLQPMG-------KLGLFYEYLEMIIQFG 675 ++ V S +++ R E++Y + GLF ++LE+ +QFG Sbjct 463 KKYRAVHKKKHEKESPAGKSVRLSTRVEKEYLKPSYTASIGEELEDGLFDDFLELTLQFG 522 Query 676 FVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILA 735 + +F +FP A +NN+ EIR DA KL +R P A IGAW I Q + ++A Sbjct 523 MIMMFACAFPSIFCFAALNNVTEIRADALKLLVMLKRPAPRDAATIGAWLNIFQFLVVMA 582 Query 736 VVTNAMIIAFTSD 748 + TN +++ D Sbjct 583 ICTNCLLLVCLYD 595 >sp|A0MFS9|CACLC_ARATH Anoctamin-like protein At1g73020 OS=Arabidopsis thaliana OX=3702 GN=At1g73020 PE=1 SV=1 Length=665 Score = 336 bits (862), Expect = 2e-102, Method: Composition-based stats. Identities = 152/695 (22%), Positives = 261/695 (38%), Gaps = 161/695 (23%) Query 84 NKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIK 143 K+ E++ + + L G+ ++ + + F+KV AP E+L A +HI+ Sbjct 19 PKRVLEEEEGDCVEVLVTELRKKGMVVDRVVGLAHE---FLKVAAPSEILGNAAAELHIR 75 Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFF 203 P + + G+ + + + S FE+ R I Sbjct 76 KPTRLG-IDLPFEMQGSEAFIRQPDGLLFSW-----------FERFRCYQHLIYG----I 119 Query 204 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263 + + + R + RL + G+ K FPLHD R++ Sbjct 120 VNSGGHDVTLKLDGREFCWTAGESL---LRRLESEGVIKQMFPLHDELKRKE-------- 168 Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323 L + WA QP+D I Y+G KIG+YF++LG YTQ L+ A++G + Sbjct 169 ----LLQNWALNWWNCTNQPIDQIYSYFGAKIGVYFSFLGMYTQWLIFPALLGFIVQMVD 224 Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383 + + + + P F V Sbjct 225 FGSL----------------QFLALPS------------------------------FFV 238 Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ---------ARPEYEARCTHVVINEI 434 +W LFL+FWKR+ A L W L Q + + + NE Sbjct 239 GTILWAALFLQFWKRKNAALLARWQINCLVGPSQGYRFLGMEWSSLPFPKELIKNLGNER 298 Query 435 TQEEE---RIPFTAWGKCIRITLCASAVFFWILLIIASVIGI-IVYRLSVFIVFSAKLPK 490 +E+E R + A+ K R + L+I S+I + + + L+ +F Sbjct 299 AKEKEAYQRYEWFAYRKRFRNDV----------LVIMSIICLQLPFELAYAHIF------ 342 Query 491 NINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSL 550 I +D I+ LT I +II L + KV++ + N E+ + NSL Sbjct 343 EIITSDIIKYVLTA----------IYLLIIQYLTRLGGKVSVKLINREINESVEYRANSL 392 Query 551 TMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTI 610 K+F F+ Y FY F + L L Sbjct 393 IYKVFGLYFMQTYIGIFYHVLLHRNF-------------------------MTLRQVLIQ 427 Query 611 IMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSE----------KITPRWEQDY----HLQ 656 + ++ + + LP++ ++ + + +I R E++Y + Sbjct 428 RLIISQVFWTLMDGSLPYLKYSYRKYRARTKKKMEDGSSTGKIQIASRVEKEYFKPTYSA 487 Query 657 PMG---KLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRL 713 +G + GLF + LE+ +QFG + +F +FPLA LA V+N++EIR +A KL RR Sbjct 488 SIGVELEDGLFDDSLELALQFGMIMMFACAFPLAFALAAVSNVMEIRTNALKLLVTLRRP 547 Query 714 VPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSD 748 +P A IGAW I Q + ++++ TN+ ++ D Sbjct 548 LPRAAATIGAWLNIWQFLVVMSICTNSALLVCLYD 582 >sp|O13621|YNG5_SCHPO Uncharacterized protein C691.05c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=pi030 PE=4 SV=1 Length=668 Score = 312 bits (798), Expect = 3e-93, Method: Composition-based stats. Identities = 134/658 (20%), Positives = 244/658 (37%), Gaps = 168/658 (26%) Query 204 NPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPN 263 + + R R+VY ++ K + + G N + + FPLH KF + Sbjct 104 DSSERIRLVYDKITGSKTEDSLGIC-PGENPYAD---IISIFPLHQPKFDIKWS------ 153 Query 264 ERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYG 323 + W KKQ LD I YG ++ +YFA+ ++ + + + G+ Sbjct 154 ------KYWYQLLLGNKKQ-LDSINAEYGSQVALYFAFADFFKTGVFVLSFWGIL----- 201 Query 324 YLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAV 383 F + +FA+ Sbjct 202 ----------------------------------------------GYYFLRPYSYIFAI 215 Query 384 FMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPF 443 + +W F++FW+ ++ +L W TV Q ++ E++ + V + R + Sbjct 216 GVALWGAFFIQFWRVQEHKLTNHWSTVNCQSLAKSMTEFKPQSYRV---DSLLGTARPYY 272 Query 444 TAWGKCIRITLCASAVFF---WILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQK 500 W +R T+ +F ILL + ++ I+ LS V+S L Sbjct 273 PQWEIIVRSTIANVPLFLISGCILLFLIAIAFIVDVTLSE--VYSGPL------------ 318 Query 501 YLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFV 560 ++ S+ +++ ++ + IY VA +T E RT+TD++ SL+ KMFL F+ Sbjct 319 ----KSIVSLLPAVVFQVLTLPFTFIYSIVAERLTKLENRRTKTDFQASLSGKMFLQNFM 374 Query 561 NYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL--------LELTTQLTIIM 612 Y++ F I++ G F Y P Y + G L L Q + Sbjct 375 LSYTALFLISYIYGPFAEY-FVPHYIQNRMSQSFFSVGYIAKSTFKLNPLRLRNQYIYFL 433 Query 613 GGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGL--------- 663 + N I + +P +++ + + H +S + E P + L Sbjct 434 TNAQVINYITILAVPQLISYVKK-HYMSKPTR-----ELHIQDIPSETVTLKRARSEAEK 487 Query 664 -----FYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKA 718 + +Y + ++ FGF+ +F +PLAP+ +LVN +L IR ++ T ++ VP + Sbjct 488 IEYDCYNDYKDFVLMFGFLVMFSPIYPLAPIFSLVNCVLYIRSSVYRFTKMVKKPVPCRV 547 Query 719 QDIGAWQPIMQGIAILAVVT----------------NAMIIA----------------FT 746 I W + ++ L +T +M+IA F Sbjct 548 DSIAPWDQRLSLLSWLGCITMPSICYFYSSTTKPSDKSMVIAAVIGLLSEHLWFLLRMFI 607 Query 747 SDMIP-------------RLVYYWSFSVPPYGDHTSYTMEGY--INNTLSIFKVADFK 789 S + P L+ SFS+PP D + T + + TLSI++ A+ K Sbjct 608 SSVFPVDKTFFAPAKERQHLLAERSFSIPPVADVPTSTTTAFEEADETLSIYRTAENK 665 >sp|Q9HCE9|ANO8_HUMAN Anoctamin-8 OS=Homo sapiens OX=9606 GN=ANO8 PE=1 SV=3 Length=1232 Score = 285 bits (730), Expect = 6e-80, Method: Composition-based stats. Identities = 116/471 (25%), Positives = 195/471 (41%), Gaps = 121/471 (26%) Query 192 NDFYIVDRDA---FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIY 241 DF + ++ FF R I+ F L ++ + ++NV I L GI Sbjct 146 EDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGII 205 Query 242 KAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAW 301 + FP+H+ + + L + W ++ + QPLD I Y+G KI +YFAW Sbjct 206 QQVFPVHEQRILNR------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAW 251 Query 302 LGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLN 361 LG+YT ++ AV G LY + D + + Sbjct 252 LGFYTSAMVYPAVFG--SVLYTFTEADQTS----------------------------RD 281 Query 362 ITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQAR 419 ++C +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ R Sbjct 282 VSC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPR 327 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479 P++ I+ IT+ EE + W + + L + + L +A ++ + + L Sbjct 328 PQFRGVRR---ISPITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLVCVFLLMLG 377 Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539 F + +L ++ G + ++L ++ +++ + Y+K+AI + + E Sbjct 378 CFQL--QELVLSVKGLPRLARFL---------PKVMLALLVSVSAEGYKKLAIWLNDMEN 426 Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599 R ++ YE L +K+ LFQFVN Y S FYI F+ Sbjct 427 YRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKD------------------------ 462 Query 600 CLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWE 650 + L L ++ + N++EVL P +L R R G + WE Sbjct 463 -MERLKEMLATLLITRQFLQNVREVLQP---HLYRRLGR--GELGLRAVWE 507 Score = 124 bits (312), Expect = 1e-27, Method: Composition-based stats. Identities = 44/103 (43%), Positives = 65/103 (63%), Gaps = 1/103 (1%) Query 643 EKITPRWEQDYHLQPMGKL-GLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRV 701 E+ +P+ Q M K F +Y EM +QFG+V LF ++FPLA L ALVNN++EIR Sbjct 723 EEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRS 782 Query 702 DAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIA 744 DA+KL T +R ++ + IG WQ +M+ + +LA+V N +I Sbjct 783 DAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIG 825 Score = 39.4 bits (90), Expect = 0.19, Method: Composition-based stats. Identities = 12/55 (22%), Positives = 26/55 (47%), Gaps = 0/55 (0%) Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENH 882 W A + ++V+EH +K+ I AIPD+ ++ + +Y ++ + Sbjct 836 WLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHE 890 >sp|Q6PB70|ANO8_MOUSE Anoctamin-8 OS=Mus musculus OX=10090 GN=Ano8 PE=1 SV=3 Length=1060 Score = 283 bits (723), Expect = 1e-79, Method: Composition-based stats. Identities = 110/450 (24%), Positives = 189/450 (42%), Gaps = 116/450 (26%) Query 192 NDFYIVDRDA---FFNPATRSRIVYFILSRVKY---QVINNVSKFG----INRLVNSGIY 241 DF + ++ FF R I+ F L ++ + ++NV I L GI Sbjct 146 EDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGII 205 Query 242 KAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAW 301 + FP+H+ + + L + W ++ + QPLD I Y+G KI +YFAW Sbjct 206 QQVFPVHEQRILNR------------LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFAW 251 Query 302 LGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLN 361 LG+YT ++ AV G LY + D + + Sbjct 252 LGFYTSAMVYPAVFG--SVLYTFTEADQTS----------------------------RD 281 Query 362 ITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQE--EQAR 419 ++C +VFA+F +W TLFLE WKRR AEL Y+W T++ E E+ R Sbjct 282 VSC--------------VVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPR 327 Query 420 PEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLS 479 P++ I+ IT+ EE + W + + L + + L +A +I + + L Sbjct 328 PQFRGIRR---ISPITRAEE-FYYPPWKRLLFQLLVS------LPLCLACLICVFILMLG 377 Query 480 VFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFEL 539 F + +L ++ G + ++L ++ +++ + Y+K+A+ + + E Sbjct 378 CFQL--QELVLSVKGLPRLVRFL---------PKVMLALLVSVSAEGYKKLAVWLNDMEN 426 Query 540 PRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGG 599 R ++ YE L +K+ LFQFVN Y S FYI F+ Sbjct 427 YRLESTYERHLIIKVVLFQFVNSYLSLFYIGFYLKD------------------------ 462 Query 600 CLLELTTQLTIIMGGKAIWNNIQEVLLPWI 629 + L L ++ + + N++EVL P + Sbjct 463 -MDRLKEMLATLLITRQLLQNVREVLQPHL 491 Score = 125 bits (314), Expect = 5e-28, Method: Composition-based stats. Identities = 47/116 (41%), Positives = 68/116 (59%), Gaps = 5/116 (4%) Query 634 GRFHRVS----GSEKITPRWEQDYHLQPMGKL-GLFYEYLEMIIQFGFVTLFVASFPLAP 688 R +R S E+ +P+ Q M K F +Y EM +QFG+V LF ++FPLA Sbjct 705 KRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAA 764 Query 689 LLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIA 744 L ALVNN++EIR DA+KL T +R + + IG WQ +M+ + +LA+V N +I Sbjct 765 LCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIG 820 Score = 39.4 bits (90), Expect = 0.21, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 26/52 (50%), Gaps = 0/52 (0%) Query 828 WHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLH 879 W A + ++V+EH+ VK+ I AIPD+ ++ + +Y ++ Sbjct 831 WLSPEAAIVSVVVLEHLALLVKYLIHVAIPDIPGWVAEEMAKLEYQRREAFK 882 >sp|P38250|IST2_YEAST Increased sodium tolerance protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=IST2 PE=1 SV=2 Length=946 Score = 87.9 bits (216), Expect = 2e-16, Method: Composition-based stats. Identities = 77/557 (14%), Positives = 165/557 (30%), Gaps = 143/557 (26%) Query 235 LVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLL---YREWAHPRSIYKKQPLDLIRKYY 291 L N ++ P HD + ++ +L + + S P Sbjct 67 LQNLDFIESIIPYHDTELSDDLHKLISISKSKILEAPKQYELYNLSNLTNNP-------- 118 Query 292 GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQC 351 K +YFA+L Y + L+ + G++ + + Sbjct 119 --KQSLYFAFLQNYIKWLIPFSFFGLSIRFLSNFTYEFNST------------------- 157 Query 352 DRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVE 411 +++F +W F FW Y+++ Sbjct 158 -----------------------------YSLFAILWTLSFTAFW-------LYKYE--- 178 Query 412 LQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVI 471 + + + T E + A K + + F + L+ ++ Sbjct 179 ---------PFWSDRLSKYSSFSTIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAI- 228 Query 472 GIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVA 531 ++ ++L F + I +L + T ++ +I N Sbjct 229 -LLSFQLYCFALEIFIKQIYNGPMISILSFLPTILICTFTP-----VLTVIYNK---YFV 279 Query 532 IMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYR 591 +T +E + + + S K F+ F++ Y F + R Sbjct 280 EPMTKWENHSSVVNAKKSKEAKNFVIIFLSSYVPLLITLFLYLPM------GHLLTAEIR 333 Query 592 NEECDPGGCLLELTT--------------QLTIIMGGKAIWNNIQEVLLPWIMNLIG--- 634 + + L L T Q + + E +P ++++ Sbjct 334 TKVFNAFSILARLPTHDSDFIIDTKRYEDQFFYFIVINQLIQFSMENFVPSLVSIAQQKI 393 Query 635 --------RFHRVSGSEKITPR----WEQD--YHLQPMG-KLGLFYEYLEMIIQFGFVTL 679 + G +++ W + Y P G L + ++++QFG++ + Sbjct 394 NGPNPNFVKAESEIGKAQLSSSDMKIWSKVKSYQTDPWGATFDLDANFKKLLLQFGYLVM 453 Query 680 FVASFPLAPLLALVNNILEIRVDAWKLTTQFRRL--VPEKAQD------------IGAWQ 725 F +PLAP + L+ N++ +VD K + + P D +G W Sbjct 454 FSTIWPLAPFICLIVNLIVYQVDLRKAV-LYSKPEYFPFPIYDKPSSVSNTQKLTVGLWN 512 Query 726 PIMQGIAILAVVTNAMI 742 ++ +IL V A + Sbjct 513 SVLVMFSILGCVITATL 529 >sp|Q9SZT4|CSCLE_ARATH CSC1-like protein At4g35870 OS=Arabidopsis thaliana OX=3702 GN=GFS10 PE=2 SV=1 Length=817 Score = 46.7 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 36/214 (17%), Positives = 69/214 (32%), Gaps = 21/214 (10%) Query 454 LCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITAS 513 + + + IL+ +S + +I + SA N D Q +LT + S Sbjct 412 VIVNTILLLILVFFSSPLALI------SALVSAGRIFNAEALDSAQYWLTWVQTSGWIGS 465 Query 514 IISFIIIMILNTIYEKVAI-----MITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFY 568 +I + + + + I ++ FE T + + + +KM F VN Sbjct 466 LIFQFLPNVFIFVSMYIVIPSALSYLSKFERHLTVSGEQRAALLKMVCFFLVNL---IIL 522 Query 569 IAFFKGKFVGYPGDPVYWL----GKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEV 624 A + R EE L + ++ Sbjct 523 KALVESSLESALLKMSRCYLDGEDCKRIEEYMSPSFLSRSCVSALAFLITSTFLGISFDL 582 Query 625 L--LPWIMNLIGRFHRVSGSEKITPRWEQDYHLQ 656 L +PWI I +F + ++ P ++Y L+ Sbjct 583 LAPIPWIKKKIQKFRKNDM-LQLVPEQNEEYALE 615 >sp|A0RPL5|TGT_CAMFF Queuine tRNA-ribosyltransferase OS=Campylobacter fetus subsp. fetus (strain 82-40) OX=360106 GN=tgt PE=3 SV=1 Length=374 Score = 40.5 bits (93), Expect = 0.055, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 39/89 (44%), Gaps = 3/89 (3%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202 +P + ++FG +N + D++ I PE + +T F + +N Y F Sbjct 273 MPTRNARNGTLFTSFGKINIKSAAFIKDDNKIDPECDCYTCSNFSRGYLNHLYKARELTF 332 Query 203 FNPATRSRIVYF--ILSRVKYQVINNVSK 229 F A+ + Y+ ++ +++ ++ K Sbjct 333 FRLASLHNLHYYLNLVKQMREAIMQGKFK 361 >sp|B9L8E1|TGT_NAUPA Queuine tRNA-ribosyltransferase OS=Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) OX=598659 GN=tgt PE=3 SV=1 Length=378 Score = 39.0 bits (89), Expect = 0.20, Method: Composition-based stats. Identities = 16/73 (22%), Positives = 30/73 (41%), Gaps = 1/73 (1%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202 +P + + FGTL +DES I P+ +T F + +N + + Sbjct 273 MPTRNARNGYLFTTFGTLRIKNAKYKLDESPIDPKCNCYTCRNFSRAYLNHLFKAKELTY 332 Query 203 FNPATRSRIVYFI 215 F A+ + Y++ Sbjct 333 FRLASIHNLHYYL 345 >sp|Q5HUF2|TGT_CAMJR Queuine tRNA-ribosyltransferase OS=Campylobacter jejuni (strain RM1221) OX=195099 GN=tgt PE=3 SV=1 Length=373 Score = 36.3 bits (82), Expect = 1.2, Method: Composition-based stats. Identities = 20/93 (22%), Positives = 35/93 (38%), Gaps = 2/93 (2%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202 +P + ++FG N D +I P +T F + +N + F Sbjct 273 MPTRNARNGTFFTSFGKFNIKKAEFINDHEVIDPTCSCYTCRNFSRGYLNHLFKAKELTF 332 Query 203 FNPATRSRIVYFI-LSRVKYQVINNVSKFGINR 234 F A+ + Y++ L+R + I N S R Sbjct 333 FRLASLHNLHYYLELARKMREAILNNSFTQFKR 365 >sp|Q1EPG7|CSPL1_MUSAC CASP-like protein 1E1 OS=Musa acuminata OX=4641 GN=MA4_106O17.50 PE=2 SV=1 Length=201 Score = 35.1 bits (79), Expect = 1.7, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 37/89 (42%), Gaps = 0/89 (0%) Query 456 ASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASII 515 +S I+L I +++ + + + I+ + +T ++ +A+ + Sbjct 30 SSTQLPGIILRIVAIVLTFISAVVMGAARQTTTVTGIDAETALLTSITVTVKSTYSAAYV 89 Query 516 SFIIIMILNTIYEKVAIMITNFELPRTQT 544 F++ +L Y V+++++ R + Sbjct 90 YFVVANVLVFFYSVVSLVLSMVNKARLTS 118 >sp|A7GYD5|TGT_CAMC5 Queuine tRNA-ribosyltransferase OS=Campylobacter curvus (strain 525.92) OX=360105 GN=tgt PE=3 SV=1 Length=388 Score = 35.5 bits (80), Expect = 2.1, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 28/73 (38%), Gaps = 1/73 (1%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTA-PFEKNRMNDFYIVDRDAF 202 +P + ++FG + D I PE E +T + + +N + F Sbjct 285 MPTRNARNGTLFTSFGKIAIKNARFVNDHEPIDPECECYTCRRYSRGYLNHLFRAHELTF 344 Query 203 FNPATRSRIVYFI 215 F A+ + Y++ Sbjct 345 FRLASLHNLHYYL 357 >sp|Q5YCC5|TMC7_CHICK Transmembrane channel-like protein 7 OS=Gallus gallus OX=9031 GN=Tmc7 PE=2 SV=1 Length=735 Score = 35.1 bits (79), Expect = 3.4, Method: Composition-based stats. Identities = 78/525 (15%), Positives = 172/525 (33%), Gaps = 107/525 (20%) Query 284 LDLIRKYYGEKIGIYFAWLGY-----YTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCH 338 + I +G I YF++L + + +L+ + V + + Y ++ + +K + Sbjct 143 IHSIEGKFGTGIQSYFSFLRFLVLLNFLMFILMFSFVTLPAVISNYGIFNSSS-TKISPN 201 Query 339 PDIGGKIIMCPQCDRLCPFW-----KLNITCESSKKLCIFDSFGTLVFAVFMGV------ 387 + P ++ ++ L + +F + T+ A F + Sbjct 202 NTEPYCTVYTPSGNKGLVYFYTYLKDLLTGTGFLEVTVLFYGYYTIDAAWFSVLRYNLPL 261 Query 388 ------WVTLFLEF-WKRRQAELEYEWDTVELQQEEQA-------------------RPE 421 + L L F W +++ + V+ + + Q+ R + Sbjct 262 AYLLTTFAYLALSFVWIIKRSVERFRQHLVDDEDQFQSYCNKVFAGWDFCITDLNAARLK 321 Query 422 YEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVF 481 + + + N EEER+ + ++ L ++ +I +I+ +V+ Y + Sbjct 322 HRSLLYELQTN---LEEERLKQKIAERTMKEKLQIYSLRIFINIIVIAVLSGCFYSIYRA 378 Query 482 IVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPR 541 VFS + + + + SI+ I N I ++ + FE Sbjct 379 TVFS----QENSSVSIRRNVMIANLLVQYLPSIV----ITSANFIAPQIFSFLIRFEDY- 429 Query 542 TQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCL 601 +E LT+ + FV V + CD C Sbjct 430 -SAAFEIRLTL-------------------IRCVFVRLANVGVLLFSLWSQIHCDNDQCK 469 Query 602 -------------LELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPR 648 + ++ ++ I++ + + + ++ + S K+ Sbjct 470 ACGYDYELYPCWESAVGQEMYKLL----IFDFMIIIAMTLFVDFPRKLLVTYCSWKLVQW 525 Query 649 WEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASF--PLAPLLALVNNILEIRVDAWKL 706 W + + G+ LE+I +G ++ +F PL P +A + + + L Sbjct 526 WG-------LQEFGISDNVLEII--YGQTICWIGTFFSPLLPAIATIKYFIIFYIKKISL 576 Query 707 TTQFRRLV--PEKAQDIGAWQPIMQGIA-ILAVVTNAMIIAFTSD 748 R+ P +A + + I ILA V + IA S Sbjct 577 IHT-RKPASRPIRASSSNFFFLAVLLIGLILAFVPLGVSIALISS 620 >sp|A1VZZ8|TGT_CAMJJ Queuine tRNA-ribosyltransferase OS=Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176) OX=354242 GN=tgt PE=3 SV=1 Length=373 Score = 34.7 bits (78), Expect = 3.5, Method: Composition-based stats. Identities = 20/93 (22%), Positives = 34/93 (37%), Gaps = 2/93 (2%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDRDAF 202 +P + ++FG N D I P +T F + +N + F Sbjct 273 MPTRNARNGTFFTSFGKFNIKKAEFINDHEAIDPACSCYTCRNFSRGYLNHLFKAKELTF 332 Query 203 FNPATRSRIVYFI-LSRVKYQVINNVSKFGINR 234 F A+ + Y++ L+R + I N S R Sbjct 333 FRLASLHNLHYYLELARKMREAILNNSFTQFKR 365 >sp|B6EK65|TGT_ALISL Queuine tRNA-ribosyltransferase OS=Aliivibrio salmonicida (strain LFI1238) OX=316275 GN=tgt PE=3 SV=1 Length=375 Score = 34.7 bits (78), Expect = 3.5, Method: Composition-based stats. Identities = 8/57 (14%), Positives = 21/57 (37%), Gaps = 1/57 (2%) Query 144 LPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAP-FEKNRMNDFYIVDR 199 +P + + G + VD + + PE + +T + K+ ++ + Sbjct 267 MPTRNARNGHLFVTGGIVKIRNAKHKVDTTPLDPECDCYTCQNYSKSYLHHLDRCNE 323 >sp|Q96NT0|CC115_HUMAN Coiled-coil domain-containing protein 115 OS=Homo sapiens OX=9606 GN=CCDC115 PE=1 SV=1 Length=180 Score = 34.0 bits (76), Expect = 3.6, Method: Composition-based stats. Identities = 18/58 (31%), Positives = 27/58 (47%), Gaps = 0/58 (0%) Query 111 EATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVL 168 EA + K+V VHAP EV A + K P K + ++ + LNWF ++ Sbjct 73 EAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILV 130 >sp|Q8VZM5|CSCL3_ARATH CSC1-like protein At4g15430 OS=Arabidopsis thaliana OX=3702 GN=At4g15430 PE=2 SV=1 Length=761 Score = 34.7 bits (78), Expect = 4.6, Method: Composition-based stats. Identities = 25/160 (16%), Positives = 45/160 (28%), Gaps = 10/160 (6%) Query 406 EWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILL 465 W Q +Q R E T + + IR + A FF Sbjct 329 RWGAAVCAQTQQTRNPTE-WLTEWAAEPRDIYYDNLALPYVDLKIRRLIVGVAYFF---- 383 Query 466 IIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNT 525 + I + + I+ L I I ++ L Sbjct 384 -LTFFFMIPIAFVQSLANIEGIEKAFPFLKPLIEVKLLKSIIQGFLPGIALKIFLLFLPR 442 Query 526 IYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSS 565 I +++ FE + + E + ++FQF+N + Sbjct 443 ILMQMS----KFEGFVSTSSLERRAATRFYMFQFINVFLG 478 >sp|Q5YCC7|TMC3_CHICK Transmembrane channel-like protein 3 OS=Gallus gallus OX=9031 GN=Tmc3 PE=2 SV=1 Length=1138 Score = 34.7 bits (78), Expect = 4.7, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 96/305 (31%), Gaps = 40/305 (13%) Query 284 LDLIRKYYGEKIGIYFAWLGYYTQM-----LLLAAVVGVACFLYGYLNQDNCTWSKEVCH 338 + I ++G + YF +L + + ++ A V + L G T SK + Sbjct 135 IKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFVVLPELLAG--APFGSTVSKTIRQ 192 Query 339 PDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT----LVFAVFMGVWVTLFLE 394 D+ + + G F V M V+ F+ Sbjct 193 EDLKTAQDLDTIWSLGGYLQYSVLFYGYYGSDRKIGKAGYRLPLAYFLVGMAVFAYSFII 252 Query 395 FWKR--RQAEL----------EYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIP 442 K+ + + + + W PE ++N I + Sbjct 253 LLKKMAKNSRMSLASASDENYTFCWRLFCAWDYLIGNPEAAESKAAAIVNSIREAILEEQ 312 Query 443 FTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYL 502 K + +T+ IIA+++ ++ S++I++ + + L Sbjct 313 EKKKSKNLAVTISLR--------IIANILVLLSLTGSIYIIYFVVDRSQKLENNKRELTL 364 Query 503 TPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNY 562 + S+ S+I MI + +E VA + PRT ++ ++ + N Sbjct 365 WEKNEVSVVVSLI----TMIAPSAFELVAAL--EMYHPRTTLRFQ---LARVLVLYLGNL 415 Query 563 YSSCF 567 YS Sbjct 416 YSLII 420 >sp|Q62812|MYH9_RAT Myosin-9 OS=Rattus norvegicus OX=10116 GN=Myh9 PE=1 SV=3 Length=1961 Score = 34.7 bits (78), Expect = 5.1, Method: Composition-based stats. Identities = 20/93 (22%), Positives = 33/93 (35%), Gaps = 13/93 (14%) Query 64 DGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVF 123 + R D +L E E K K E + + + +S L+ LQL+ + Sbjct 839 NSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAKTE---- 894 Query 124 VKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSS 156 LC AE + +L K +L+ Sbjct 895 ---------LCAEAEELRARLTAKKQELEEICH 918 >sp|Q9ULH1|ASAP1_HUMAN Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4 Length=1129 Score = 34.7 bits (78), Expect = 5.3, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 25/63 (40%), Gaps = 0/63 (0%) Query 61 FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK 120 FF DG + D + Y ++ + + + +K+ +LI LQL+ + Sbjct 250 FFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQ 309 Query 121 LVF 123 + Sbjct 310 GGY 312 >sp|Q8VDD5|MYH9_MOUSE Myosin-9 OS=Mus musculus OX=10090 GN=Myh9 PE=1 SV=4 Length=1960 Score = 34.3 bits (77), Expect = 6.4, Method: Composition-based stats. Identities = 20/93 (22%), Positives = 33/93 (35%), Gaps = 13/93 (14%) Query 64 DGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVF 123 + R D +L E E K K E + + + +S L+ LQL+ + Sbjct 839 NSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETE---- 894 Query 124 VKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSS 156 LC AE + +L K +L+ Sbjct 895 ---------LCAEAEELRARLTAKKQELEEICH 918 Lambda K H a alpha 0.318 0.127 0.347 0.792 4.96 Gapped Lambda K H a alpha sigma 0.267 0.0388 0.140 1.90 42.6 43.6 Effective search space used: 105226848522 Database: uniprot_sprot.fasta Posted date: Aug 1, 2024 3:29 PM Number of letters in database: 207,016,062 Number of sequences in database: 571,864 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40