PSIBLAST 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment: Stephen F.
Altschul, John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005)
"Protein database searches using compositionally adjusted
substitution matrices", FEBS J. 272:5101-5109.
Reference for composition-based statistics starting in round 2:
Alejandro A. Schaffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: uniprot_sprot.fasta
571,609 sequences; 206,878,625 total letters
Results from round 1
Query= sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapiens
OX=9606 GN=SMPD1 PE=1 SV=5
Length=631
Score E
Sequences producing significant alignments: (Bits) Value
sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapie... 1288 0.0
sp|Q0VD19|ASM_BOVIN Sphingomyelin phosphodiesterase OS=Bos taurus... 1043 0.0
sp|Q04519|ASM_MOUSE Sphingomyelin phosphodiesterase OS=Mus muscul... 1001 0.0
sp|Q23498|ASM2_CAEEL Sphingomyelin phosphodiesterase 2 OS=Caenorh... 380 4e-123
sp|Q9UAY4|ASM3_CAEEL Putative sphingomyelin phosphodiesterase asm... 353 8e-113
sp|Q54C16|SGMB_DICDI Sphingomyelin phosphodiesterase B OS=Dictyos... 335 2e-105
sp|Q10916|ASM1_CAEEL Sphingomyelin phosphodiesterase 1 OS=Caenorh... 328 1e-103
sp|Q55C09|SGMA_DICDI Sphingomyelin phosphodiesterase A OS=Dictyos... 273 4e-82
sp|Q54SR8|SGMC_DICDI Sphingomyelinase phosphodiesterase C OS=Dict... 194 4e-54
sp|Q92485|ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesteras... 189 3e-52
sp|Q641Z7|ASM3A_RAT Cyclic GMP-AMP phosphodiesterase SMPDL3A OS=R... 188 4e-52
sp|P70158|ASM3A_MOUSE Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 181 2e-49
sp|Q92484|ASM3A_HUMAN Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 177 6e-48
sp|Q3ZC91|ASM3A_BOVIN Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 177 9e-48
sp|P58242|ASM3B_MOUSE Acid sphingomyelinase-like phosphodiesteras... 176 1e-47
sp|Q55GC7|SGMD_DICDI Sphingomyelinase phosphodiesterase D OS=Dict... 104 1e-22
sp|Q9C1W8|PPN1_SCHPO Endopolyphosphatase OS=Schizosaccharomyces p... 85.1 5e-16
sp|Q9P3S1|PPN1_NEUCR Endopolyphosphatase OS=Neurospora crassa (st... 84.7 8e-16
sp|Q5KH67|PPN1_CRYNJ Endopolyphosphatase OS=Cryptococcus neoforma... 84.7 9e-16
sp|Q6FMQ0|PPN1_CANGA Endopolyphosphatase OS=Candida glabrata (str... 76.6 3e-13
sp|Q6BKG0|PPN1_DEBHA Endopolyphosphatase OS=Debaryomyces hansenii... 70.1 3e-11
sp|Q756F2|PPN1_EREGS Endopolyphosphatase OS=Eremothecium gossypii... 65.9 7e-10
sp|Q6CWT7|PPN1_KLULA Endopolyphosphatase OS=Kluyveromyces lactis ... 65.5 1e-09
sp|Q04119|PPN1_YEAST Endopolyphosphatase OS=Saccharomyces cerevis... 63.9 3e-09
sp|Q6CEE7|PPN1_YARLI Endopolyphosphatase OS=Yarrowia lipolytica (... 53.9 4e-06
sp|Q75EN9|CCZ1_EREGS Vacuolar fusion protein CCZ1 OS=Eremothecium... 35.8 1.3
sp|B0SUK3|THIE_CAUSK Thiamine-phosphate synthase OS=Caulobacter s... 35.0 1.3
sp|Q8H5F8|ADPRM_ORYSJ Manganese-dependent ADP-ribose/CDP-alcohol ... 34.7 2.6
sp|Q99NB2|B3GN5_RAT Lactosylceramide 1,3-N-acetyl-beta-D-glucosam... 33.9 4.3
sp|Q9SB68|ADPRM_ARATH Manganese-dependent ADP-ribose/CDP-alcohol ... 33.5 5.5
sp|P26779|SAP_BOVIN Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1... 33.5 7.9
sp|Q03L46|METE_STRTD 5-methyltetrahydropteroyltriglutamate--homoc... 33.1 9.9
>sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapiens
OX=9606 GN=SMPD1 PE=1 SV=5
Length=631
Score = 1288 bits (3332), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 631/631 (100%), Positives = 631/631 (100%), Gaps = 0/631 (0%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE
Sbjct 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
Query 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK
Sbjct 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
Query 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL
Sbjct 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
Query 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR
Sbjct 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
Query 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT
Sbjct 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
Query 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL
Sbjct 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
Query 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
Sbjct 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
Query 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV
Sbjct 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
Query 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR
Sbjct 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
Query 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
Sbjct 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
Query 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
ARADSPALCRHLMPDGSLPEAQSLWPRPLFC
Sbjct 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
>sp|Q0VD19|ASM_BOVIN Sphingomyelin phosphodiesterase OS=Bos taurus
OX=9913 GN=SMPD1 PE=2 SV=1
Length=625
Score = 1043 bits (2696), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 535/631 (85%), Positives = 569/631 (90%), Gaps = 6/631 (1%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
MPR+G S Q PRSGREQ D + GAP + L L LALALAL +S VLW+PAE
Sbjct 1 MPRHGVSPGQGLPRSGREQASDRSLGAP------CLRLLWLGLALALALPNSPVLWSPAE 54
Query 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
A PL QGHPA+ RI P+L++ FGW NLTCP CKGLFTAI+ GL+ + +VA VGSVAIK
Sbjct 55 ARPLPTQGHPAKFIRIAPQLQEAFGWWNLTCPTCKGLFTAIDFGLRNQASVAWVGSVAIK 114
Query 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
LC LLKIAPPAVCQS V LFEDDMVEVW RSVLSPSEACGLLLGS+CGHWDIFSSWNISL
Sbjct 115 LCVLLKIAPPAVCQSAVQLFEDDMVEVWTRSVLSPSEACGLLLGSSCGHWDIFSSWNISL 174
Query 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
P VPKPPP+PP PPAPG+PVSR+LFLTDLHWDHDYLEGTDP+C +PLCCRR SG PPAS+
Sbjct 175 PAVPKPPPQPPKPPAPGSPVSRVLFLTDLHWDHDYLEGTDPNCENPLCCRRDSGPPPASQ 234
Query 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAH++W Q+RQDQLRALTT
Sbjct 235 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHNIWQQSRQDQLRALTT 294
Query 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
+TALV+KFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS WLYEAMA+AWEPWLPAEAL
Sbjct 295 ITALVKKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSHWLYEAMAEAWEPWLPAEAL 354
Query 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
RTLRIGGFYALSP PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
Sbjct 355 RTLRIGGFYALSPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 414
Query 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
KVHIIGHIPPGHCLKSWSWNYYRIV RYENTLA QFFGHTHVDEFEVFYDEETLSRPL+V
Sbjct 415 KVHIIGHIPPGHCLKSWSWNYYRIVERYENTLAGQFFGHTHVDEFEVFYDEETLSRPLSV 474
Query 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYI+NLT+AN PGA PHW LLYR
Sbjct 475 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIMNLTEANEPGATPHWYLLYR 534
Query 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
ARETYGLPN LPTAWH+LVYRMR D QLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
Sbjct 535 ARETYGLPNALPTAWHDLVYRMRKDTQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 594
Query 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
AR+DSPALCRHL+PD SLP+ QSLW PL C
Sbjct 595 ARSDSPALCRHLVPDASLPDVQSLWSMPLLC 625
>sp|Q04519|ASM_MOUSE Sphingomyelin phosphodiesterase OS=Mus musculus
OX=10090 GN=Smpd1 PE=1 SV=2
Length=627
Score = 1001 bits (2588), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 518/633 (82%), Positives = 555/633 (88%), Gaps = 8/633 (1%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAP--GLLWMGLVLALALALALALALSDSRVLWAP 58
MP + AS Q R+G EQ + + AP GLLWM L LAL LAL DS VLW P
Sbjct 1 MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWM------GLGLALVLALFDSTVLWVP 54
Query 59 AEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVA 118
A A+PL +GH + I P L+ FGW NLTCP CK LFTA+N GLKKEPNVARVGSVA
Sbjct 55 ARAYPLPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVA 114
Query 119 IKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNI 178
IK+C +L IAP VCQS VHLFEDD+VEVW RSVLSPSEACGLLLGS+CGHWDIFS+WNI
Sbjct 115 IKICKMLNIAPLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNI 174
Query 179 SLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPA 238
SLP+VPKPPPKPPSPPAPGAPVSR+LFLTDLHWDH+YLEGTDP CADPLCCRRGSG PP
Sbjct 175 SLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPN 234
Query 239 SRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRAL 298
S+ GAG+WGEYSKCDLPLRTLESLL GLGPAGPF+MVYWTGDIPAHDVW Q+RQDQLRAL
Sbjct 235 SQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRAL 294
Query 299 TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAE 358
TT+T LVRKFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS+WLYEAMAKAWEPWLPA+
Sbjct 295 TTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPAD 354
Query 359 ALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDR 418
AL TLRIGGFYAL+P PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLV ELQAAE+R
Sbjct 355 ALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENR 414
Query 419 GDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPL 478
GDKVHIIGHIPPGHCLKSWSWNYY+I+ARYENTLA QFFGHTHVDEFE+FYDEETLSRPL
Sbjct 415 GDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPL 474
Query 479 AVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLL 538
AVAFLAPSATT+I LNPGYRVYQIDGNY GSSHVVLDHETYILNLTQAN G P W+ L
Sbjct 475 AVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRL 534
Query 539 YRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ 598
YRARETYGLP+ +P +WHNLVYRMR D QLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ
Sbjct 535 YRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ 594
Query 599 LSARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
LSARADSPALCRHLMP+GSLP+A LW RPL C
Sbjct 595 LSARADSPALCRHLMPNGSLPDANRLWSRPLLC 627
>sp|Q23498|ASM2_CAEEL Sphingomyelin phosphodiesterase 2 OS=Caenorhabditis
elegans OX=6239 GN=asm-2 PE=1 SV=3
Length=618
Score = 380 bits (977), Expect = 4e-123, Method: Compositional matrix adjust.
Identities = 216/615 (35%), Positives = 329/615 (53%), Gaps = 41/615 (7%)
Query 35 LVLALALALALALALSDSRVLWAPAEAHPL----SPQGHPA-------RLHRIVPRLRDV 83
++L + + LAL + +S VL P + H + +G+ A ++ R + +
Sbjct 6 IILGIGIVLALVSNV-ESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINE 64
Query 84 FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDD 143
++C C + + + + + + LC+L + P VC++I++ F+D+
Sbjct 65 PENRKMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKDE 124
Query 144 MVEVWRRSVLSPSEACGLLLGSTCGHWD--IFSSWNISLPTVPKPPPKPPSPPAPGAPVS 201
+V V RSV +P E CG + + CGH D + WNI++P KPP KP P
Sbjct 125 VVFVLERSVFTPEEICGAFIAN-CGHSDKPLTHMWNITIPG-GKPPIKPWPKIPDNKPTF 182
Query 202 RILFLTDLHWDHDYLEGTDPDC-------ADPLCCRRGS----GLPPASRPG-----AGY 245
++L L+D+H DH Y+ GT+ C +CCR S G P + AG
Sbjct 183 KVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVPAGP 242
Query 246 WGEYSKCDLPLRTLESLLSGLGPA-GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTAL 304
WG CDLP +T ES + + D + TGD AHD W T + +T +
Sbjct 243 WGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNV 302
Query 305 VRKFLGPVPVYPAVGNHESTPVNSFPPPFI--EGNHSSRWLYEAMAKAWEPWLPAEALRT 362
++ VPVY ++GNHE P ++ P + +WLY+ M++ W W+P EAL T
Sbjct 303 FLEYFPGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDT 362
Query 363 LRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKV 422
++ YA+ P PGL+LISLN +CS NF+L +N DP L+WL+ ELQ +E++G+ V
Sbjct 363 VQYRASYAVYPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELV 422
Query 423 HIIGHIPPG--HCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYD-EETLSRPLA 479
HII HIPPG +CLK WSWN++ IV RYENT+A F+GHTH D+F V+YD ++ RP
Sbjct 423 HIISHIPPGDNYCLKGWSWNFFEIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFH 482
Query 480 VAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLY 539
+++PS TTY LNP YR+Y+IDG Y G+++ V D +TY N+T+AN+ P W L Y
Sbjct 483 FNWISPSLTTYDWLNPAYRIYEIDGGYEGATYTVKDAKTYFANVTEANMKNKEPEWVLSY 542
Query 540 RARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGT--PCRLATLCA 597
RE Y + + P +W +L ++ + LF+ + LY++ H +E C T CR +C
Sbjct 543 DTREHYQMADFSPQSWSDLSDKLWTNTTLFRDYVRLYYRNHYNNE-CYTDYKCRYTFVCD 601
Query 598 QLSARADSPALCRHL 612
R+ + C HL
Sbjct 602 IKKGRSYDESFCDHL 616
>sp|Q9UAY4|ASM3_CAEEL Putative sphingomyelin phosphodiesterase
asm-3 OS=Caenorhabditis elegans OX=6239 GN=asm-3 PE=3 SV=2
Length=589
Score = 353 bits (905), Expect = 8e-113, Method: Compositional matrix adjust.
Identities = 190/522 (36%), Positives = 279/522 (53%), Gaps = 17/522 (3%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C CK + + ++ V +A+ +C I VC I+ F D+ + V ++
Sbjct 21 CEECKSIVDLLQFEWGEKKTEECVMEIAVFICETFHIEDNDVCNFIISDFSDEFMYVIKQ 80
Query 151 SVLSPSEACGLLLGSTCGHWD--IFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTD 208
+++P + CGLL+ + CG + + + WN+++P +PP P PG P R L LTD
Sbjct 81 ILVTPHQLCGLLMKNDCGDFVDPLATIWNMTIPG-NQPPFVPKQVVPPGNPTLRALHLTD 139
Query 209 LHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPG-----AGYWGEYSKCDLPLRTLESLL 263
LH D Y G + DC P CCR G AG WG CD P L ++L
Sbjct 140 LHVDMFYTVGLEADCGTPQCCRPQDMNVEIVENGDVKQPAGPWGSVGSCDTPYWLLTNML 199
Query 264 SGLGP-AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHE 322
+ AG D + +GD+ +H VW T + + ++ +R + PVY AVGNHE
Sbjct 200 QNIASTAGKLDYIMVSGDLVSHTVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHE 259
Query 323 STPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISL 382
PV++ P F + WLY+AM+ AW+ W+PA+ ++L G Y Y GLR+ISL
Sbjct 260 GVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEYNGCYMKKIYDGLRMISL 319
Query 383 NMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSWSWN 440
N + R NFWL IN TDP G LQWL+ +LQ AE+ GDKVHI+ HIP G L+ ++ N
Sbjct 320 NNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALN 379
Query 441 YYRIVARYENTLAAQFFGHTHVDEFEVFYD--EETLSRPLAVAFLAPSATTYIGLNPGYR 498
YY+I+ RY NT+ QFFGHTH ++F + Y ++ S P V + APS T Y P YR
Sbjct 380 YYKIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDYFPAYR 439
Query 499 VYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR-ARETYGLPNTLPTAWHN 557
+Y IDG + GS++ V+D+E + NLT N W++LY+ A YGL +PT ++
Sbjct 440 IYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNVKWEVLYQSANMEYGLKGQIPTEYNQ 499
Query 558 LVYRMRGDMQLFQTFWFLYHKG--HPPSEPCG-TPCRLATLC 596
++ RM+ D LF ++ +++ + PC CR LC
Sbjct 500 MIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLC 541
>sp|Q54C16|SGMB_DICDI Sphingomyelin phosphodiesterase B OS=Dictyostelium
discoideum OX=44689 GN=sgmB PE=3 SV=1
Length=637
Score = 335 bits (860), Expect = 2e-105, Method: Compositional matrix adjust.
Identities = 203/537 (38%), Positives = 288/537 (54%), Gaps = 32/537 (6%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C ICK + + + + + AI LC L I VC ++ LF + V
Sbjct 77 CDICKFGINQVQKMIASKQGIEDISKYAIDLCTYLHIEKAEVCNGLIPLFANMTYNVLSY 136
Query 151 SVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLH 210
++ CG + C + SS NI PKPP PP P+P +P +IL ++D+H
Sbjct 137 PTVTGEYVCGFV--GFCPYVPRNSS-NIINFPKPKPPHVPPVAPSPNSPTMKILHISDIH 193
Query 211 WDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGP-- 268
D Y G + DC +PLCCR +G P AG WG Y CD+ ++ +ES+ +
Sbjct 194 VDPVYESGMNADCGEPLCCRAPNG-PGVGEKAAGEWGHY-LCDINMKMVESMFEFIDQEF 251
Query 269 AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPV-PVYPAVGNHESTPVN 327
D+V+WTGD P HD+W QT Q+ A VT LV+K+ G V+PA+GNHES PVN
Sbjct 252 GEDIDIVFWTGDNPPHDIWEQTYDSQINASQLVTNLVKKYFGSTAKVFPAIGNHESLPVN 311
Query 328 SFP-PPFIEGNHSSRWLYEAMAKAWEPWLPA-EALRTLRIGGFYALSPYPGLRLISLNMN 385
SFP PP S W++ A++ W W+ E + L+ GG+Y L GLR+ISLNMN
Sbjct 312 SFPLPP------GSSWIFNALSYDWSDWVNVDEQVANLQYGGYYTLPVQSGLRVISLNMN 365
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG--HCLKSWSWNYYR 443
+C+ N +L NSTDPA LQW+V LQA+ED G+KV+++GHIPPG C+ SWS +
Sbjct 366 WCNNGNLYLAENSTDPANMLQWIVDTLQASEDIGEKVYLVGHIPPGIPDCIDSWSEQLLQ 425
Query 444 IVARYENTLAAQFFGHTHVDEFEVFY---DEETLSRPL---AVAFLAPSATTYIGLNPGY 497
IV RYE+T+ A F+GHTH DEF V+Y DE S P+ V + PS TTY NP +
Sbjct 426 IVNRYEDTILASFYGHTHRDEFSVYYTQSDENDPSSPMRASNVIYTTPSVTTYQHQNPSF 485
Query 498 RVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHN 557
R++ +D N + +++ TY +L+QAN+ G P W L Y TY +PN P +
Sbjct 486 RIFTVDSN----TGYLMESSTYHTDLSQANLNGK-PTWLLEYNTTNTYNIPNLTPISMDL 540
Query 558 LVYRMRGDMQLFQTFWFLYHKG--HPPSEPCGT-PCRLATLCAQLSARADSPALCRH 611
+ + + + + Y+ +P S+PC + C+L +C SA C H
Sbjct 541 AIQNINSSNSMLEDYHVHYYSASPYPESKPCTSISCKLDYICKMKSAAYLKYYECIH 597
>sp|Q10916|ASM1_CAEEL Sphingomyelin phosphodiesterase 1 OS=Caenorhabditis
elegans OX=6239 GN=asm-1 PE=1 SV=2
Length=564
Score = 328 bits (841), Expect = 1e-103, Method: Compositional matrix adjust.
Identities = 184/539 (34%), Positives = 283/539 (53%), Gaps = 21/539 (4%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFE 141
D +G+ L C C GL + + LK + + + A +C L P AVC I F
Sbjct 33 DKYGFQPL-CISCTGLISVASFFLKFDVSEPVILEFATIVCKLFAKQPWAVCDGISSQFR 91
Query 142 DDMVEVWRR-SVLSPSEACGLLLGSTCGHWD-IFSSWNISLPTVPKPP--PKPPSPPAPG 197
D+ V+RR + SPS+ CG++L D S W ++LP PK K P
Sbjct 92 DEFFYVFRRLANESPSQICGIILPDCADPTDPSESGWMVALPPKPKRTRISKKKVQKKPN 151
Query 198 APVSR---ILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDL 254
+S+ +L LTDLH D +Y ++ +C DP+CCR P + AGYWG KCD+
Sbjct 152 MSMSQNLNVLQLTDLHVDFEYKYPSEANCDDPVCCRVSVSEP---KKAAGYWGSVGKCDI 208
Query 255 PLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPV 314
P T+E++LS + DMV TGD H W + ++ L L + LV+ P+
Sbjct 209 PFWTVENMLSHINKTHMIDMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPSTPI 268
Query 315 YPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPY 374
Y A+GNHE PVNSF P ++ WLY+ PWL A +L G Y+
Sbjct 269 YWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVM 328
Query 375 PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG--H 432
GL+LI+LN FC NF+L +N +DP + W V EL +E +G++V+++ HIPPG
Sbjct 329 DGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSE 388
Query 433 CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDE--ETLSRPLAVAFLAPSATTY 490
CL+ W++NYYR++ R+ +T+AAQFFGH H+D F VFY++ S+P++V + +PS TT+
Sbjct 389 CLEGWAFNYYRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTF 448
Query 491 IGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNT 550
NP YR+Y+ID + ++D TY +L +A P W+ LY AR+ +G+ +
Sbjct 449 EYQNPAYRIYEID---PYNKFKIVDFTTYYADLEKAT-EDKKPVWEKLYSARQAHGMDDL 504
Query 551 LPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALC 609
P +W+ ++ ++ + + F+ + P C + C++ +C +S C
Sbjct 505 SPLSWNKVIQKLFTSEKKREKFYQYAFRNFSPQ--CDSTCQMQLMCNLRMGHHNSTLYC 561
>sp|Q55C09|SGMA_DICDI Sphingomyelin phosphodiesterase A OS=Dictyostelium
discoideum OX=44689 GN=sgmA PE=3 SV=1
Length=583
Score = 273 bits (697), Expect = 4e-82, Method: Compositional matrix adjust.
Identities = 166/535 (31%), Positives = 269/535 (50%), Gaps = 47/535 (9%)
Query 89 LTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVW 148
L+C +C+ + + +KK ++ + LC K P VC I++ + +V+V
Sbjct 53 LSCDVCQIGASLLEDFIKKNASLTEIIKGLSDLCIASKEEQPEVCTGILNNYVPIIVDVL 112
Query 149 RRSVLSPSEACGLL-LGSTCGHW----------DIFSSWNISLPTVP---KPPPKPPSPP 194
+S +PS+ CG + S G + + + + PT+ KP K S
Sbjct 113 IQSDFTPSQLCGYFKICSATGSSESSSISNSFDNEYRQESFNKPTMKVNKKPQYKDLSNQ 172
Query 195 AP-------GAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWG 247
P + IL ++D+H+D DY G++P+C PLCCR G G AG G
Sbjct 173 EPLVKKFKGNDSIGYILQISDVHFDPDYKVGSNPNCGRPLCCRDGVG-------SAGPIG 225
Query 248 EYSKCDLPLRTLESLLSGLGP-AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVR 306
Y CD+P T+E + L D + WTGD P H+VW Q++ Q A T+ +++
Sbjct 226 HY-LCDIPFSTVELIFQHLATLTDQLDFIVWTGDNPPHNVWEQSQAQQELATATLAQVIQ 284
Query 307 KFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIG 366
K PV P++GNHE+ P + + P +S+WL +++ W PWL A+AL ++
Sbjct 285 KTFPNTPVLPSLGNHEAYPADQYVLP------NSQWLLDSIYTYWAPWLDADALELVKER 338
Query 367 GFYALSPYPGLRLISLNMNFCSRENFWLLINS--TDPAGQLQWLVGELQAAEDRGDKVHI 424
G+Y PGLR++SLN NF+ L+ + P Q W++ L+ A+ G+KV I
Sbjct 339 GYYTSLIKPGLRVMSLNTLENDMINFYNLLPTYLKGPNNQSDWMINTLEQAQSNGEKVLI 398
Query 425 IGHIP---PGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVA 481
IGHIP W Y ++V ++ + + Q +GHTH D+F VF D T + P +
Sbjct 399 IGHIPCTVKSASTDGWCAMYEQVVGQFSDVIIGQLYGHTHYDQFSVFSDVATHTIPTGMN 458
Query 482 FLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRA 541
++ PS TTY PGYR+YQ D S++ ++++ Y N+T+AN GA+ ++QL Y A
Sbjct 459 YIVPSLTTYQNHEPGYRIYQFD----YSTNQIVNYYQYHANITEANETGAL-NFQLTYSA 513
Query 542 RETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLC 596
+E Y + + PT+W + +M+ + +F ++ F P E C C+ +C
Sbjct 514 KELYNMDDLSPTSWTKVANQMKTNSTMFNSY-FENLSSSPIKESCDQACQTKWIC 567
>sp|Q54SR8|SGMC_DICDI Sphingomyelinase phosphodiesterase C OS=Dictyostelium
discoideum OX=44689 GN=sgmC PE=3 SV=1
Length=446
Score = 194 bits (493), Expect = 4e-54, Method: Compositional matrix adjust.
Identities = 130/413 (31%), Positives = 200/413 (48%), Gaps = 40/413 (10%)
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
+TD H+D Y+EG D D CR + + GA G Y KCD L+S
Sbjct 37 ITDTHYDFMYIEGGDEDKQ----CREVTYKSKYEKGGASSIGNY-KCDTSFELLQSSFEY 91
Query 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQD-QLRALTTVTALVRKFLGPVPVYPAVGNHES 323
+ D + WTGD P H Q + L+++T +T L++ + +P++P++GNH+S
Sbjct 92 MVKHEEKPDFIIWTGDDPPHLGNSQLNETLVLQSITNMTNLIKGYFPDIPIFPSIGNHDS 151
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 383
P + WL+E +A+ W P+L +++ T ++GG+Y G R+ISLN
Sbjct 152 YPQHQIGV-------GPNWLFENVAQLWSPFLSNDSIETFKLGGYYTELVSEGFRIISLN 204
Query 384 MNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYR 443
F EN L N TDPAGQL WL L A G++V IIGH+PPG+ K +N+++
Sbjct 205 TVFYYNENRQCL-NLTDPAGQLLWLNETLANASLAGERVWIIGHVPPGYNEKYDVFNFHK 263
Query 444 --------IVARYENTLAAQFFGHTHVDEFEVFYDEETLS----RPLAVAFLAPSATTYI 491
++Y + + +GH H D F +FYD+ P + FL+PS T ++
Sbjct 264 QFNDEYLFSFSQYSDIIEFHIYGHEHTDTFRLFYDDPNDHINDIEPTGIMFLSPSLTPWM 323
Query 492 GL-------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARET 544
NPG R+Y+ Y+ +S +LD+ + NLT I G I WQL YRA E
Sbjct 324 NQFLPALPNNPGLRLYE----YNITSFALLDYYQFWTNLTDNIISGNID-WQLEYRATEF 378
Query 545 YGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCA 597
+ N P + + ++ F F Y+ P++ C C+ LC+
Sbjct 379 FNTFNLSPVSMYEAYLLIQSVTSQLLKFHF-YNSVSYPTKGCDEICKKIQLCS 430
>sp|Q92485|ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesterase
3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2
Length=455
Score = 189 bits (481), Expect = 3e-52, Method: Compositional matrix adjust.
Identities = 135/440 (31%), Positives = 202/440 (46%), Gaps = 49/440 (11%)
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
+ DLH D DY DP P +G P P AG WG+Y CD P + S +
Sbjct 26 IADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDY-LCDSPWALINSSIYA 77
Query 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLGPVPVYPAVGNHES 323
+ P D + WTGD H + + L + +T L+R+ VY A+GNH+
Sbjct 78 MKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDF 137
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS---PYPGLRLI 380
P N FP S +Y +A+ W+PWL E++ + G FY P R++
Sbjct 138 HPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIV 190
Query 381 SLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKS---- 436
LN N N L + DP Q QWL L A GD V+I+GH+PPG K+
Sbjct 191 VLNTNLYYTSNA-LTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA 249
Query 437 -----WSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSA---- 487
++ Y ++V ++ +A QFFGH H D F + YD+ + P++ F+ P
Sbjct 250 WFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGV--PISAMFITPGVTPWK 307
Query 488 TTYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRAR 542
TT G+ NP RV++ Y ++ + D TY +NL+QAN G P W+L Y+
Sbjct 308 TTLPGVVNGANNPAIRVFE----YDRATLSLKDMVTYFMNLSQANAQGT-PRWELEYQLT 362
Query 543 ETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSAR 602
E YG+P+ + H ++ R+ GD Q + ++Y+ + C C + +CA
Sbjct 363 EAYGVPDASAHSMHTVLDRIAGDQSTLQRY-YVYNSVSYSAGVCDEACSMQHVCAMRQVD 421
Query 603 ADSPALCRHLMPDGSLPEAQ 622
D+ C L G+ P Q
Sbjct 422 IDAYTTC--LYASGTTPVPQ 439
>sp|Q641Z7|ASM3A_RAT Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Rattus norvegicus OX=10116 GN=Smpdl3a PE=2 SV=1
Length=445
Score = 188 bits (478), Expect = 4e-52, Method: Compositional matrix adjust.
Identities = 139/445 (31%), Positives = 215/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA GAP V + +TDLH D Y TD D +G+ + S PG +G+
Sbjct 24 PLAPAYGAPAVGQFWHVTDLHLDPTY-HITD-DHTKVCASSKGANV---SNPGP--FGDV 76
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + + +T +T V+
Sbjct 77 -LCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVRELSTGSVIEVITNMTVTVQN 135
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P ++ +Y A++ W+PWL EA+ TLR GG
Sbjct 136 LFPNLQVFPALGNHDYWPQDQLPI-------ATSKVYSAVSDLWKPWLDEEAISTLRKGG 188
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV++I
Sbjct 189 FYSQKVASNPDLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLRNKEKVYVI 247
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 248 AHVPVGYLPYATKTPAMRQYYNEKLVDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 305
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
P+ F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 306 PINSVFVAPAVTPVKGVLEKETNNPGVRLFQ----YKPGDYTLLDMLQYYLNLTEANLKG 361
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + YG+ + P + H L ++ D + F ++ + + S PC
Sbjct 362 E-SNWTLEYTLTQAYGVADLQPKSLHGLAQQLATIDSKQFLKYYHYFFVSYDSSAPCDQR 420
Query 590 CRLATLCAQLSARADSPALC--RHL 612
C+ +CA ++ S C RHL
Sbjct 421 CKTLQICAIMNLDLVSYEDCLKRHL 445
>sp|P70158|ASM3A_MOUSE Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Mus musculus OX=10090 GN=Smpdl3a PE=1 SV=2
Length=445
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 24 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 75
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 76 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 135
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 136 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 188
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 189 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 247
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 248 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 305
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 306 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 361
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 362 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 420
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 421 CKTLQVCAIMNLDSMSYDDCLKQHL 445
>sp|Q92484|ASM3A_HUMAN Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Homo sapiens OX=9606 GN=SMPDL3A PE=1 SV=2
Length=453
Score = 177 bits (449), Expect = 6e-48, Method: Compositional matrix adjust.
Identities = 139/452 (31%), Positives = 213/452 (47%), Gaps = 49/452 (11%)
Query 178 ISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPP 237
+ LP P PP PA G + +TDLH D Y TD D +G+
Sbjct 21 LGLPVAPAGGRNPP--PAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN--- 69
Query 238 ASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-L 295
AS PG +G+ CD P + + S + +G + WTGD P H + D +
Sbjct 70 ASNPGP--FGDV-LCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVI 126
Query 296 RALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWL 355
+T +T ++ + V+PA+GNH+ P + P + +Y A+A W+PWL
Sbjct 127 NVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWL 179
Query 356 PAEALRTLRIGGFYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQ 413
EA+ TLR GGFY+ ++ P LR+ISLN N N + +N TDPA Q +WL L
Sbjct 180 DEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLN 238
Query 414 AAEDRGDKVHIIGHIPPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDE 464
++ +KV+II H+P G+ S + YY I +Y + +A QF+GHTH D
Sbjct 239 NSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDS 298
Query 465 FEVFYDEETLSRPLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHET 518
V D++ P+ F+AP+ T + NPG R++Q Y + +LD
Sbjct 299 IMVLSDKK--GSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQ 352
Query 519 YILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYH 577
Y LNLT+AN+ G W+L Y +TY + + P + + L + D + F ++ +
Sbjct 353 YYLNLTEANLKGE-SIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFF 411
Query 578 KGHPPSEPCGTPCRLATLCAQLSARADSPALC 609
+ S C C+ +CA ++ S A C
Sbjct 412 VSYDSSVTCDKTCKAFQICAIMNLDNISYADC 443
>sp|Q3ZC91|ASM3A_BOVIN Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Bos taurus OX=9913 GN=SMPDL3A PE=2 SV=1
Length=450
Score = 177 bits (448), Expect = 9e-48, Method: Compositional matrix adjust.
Identities = 130/440 (30%), Positives = 205/440 (47%), Gaps = 43/440 (10%)
Query 190 PPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P +P G V + +TD H D Y D C G AS PG +G+
Sbjct 24 PLAPAGTGPAVGQFWHVTDFHLDPTYHITGD----HTKVCASSKG-AEASDPGP--FGD- 75
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQLRALT-TVTALVRK 307
CD P R + S L + +G + WTGD P H + D++ +T +T +++
Sbjct 76 VMCDSPYRLIFSALDFIKNSGQKVSFMIWTGDSPPHVPVLELSTDKVINVTANITTTIQR 135
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL +A+ TLR GG
Sbjct 136 LFPNLQVFPALGNHDYWPQDQLPV-------VNSKVYNAVANLWKPWLTEDAITTLRKGG 188
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY +S P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 189 FYTQKVSNNPKLRIISLNTNLYYGPN-SVTLNQTDPANQFEWLENTLNISQQNKEKVYII 247
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ K + I +Y + +A QF+GHTH D V D++ +
Sbjct 248 AHVPVGYLPYARGISAMRKYHNEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKK--GK 305
Query 477 PLAVAFLAPSAT------TYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
P+ F+AP+ T + NPG R++Q Y + +LD Y LNLT AN+ G
Sbjct 306 PVNSLFVAPAVTPVRSVLERLTNNPGVRLFQ----YDPRDYKLLDMLQYYLNLTDANLKG 361
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMR-GDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W+L Y + Y + + P + + L + + + F ++ + + S C
Sbjct 362 E-SNWKLEYNLTQAYDIQDLQPKSLYKLAKQFAIQESKQFIKYYKYFFVSYDSSVICQGK 420
Query 590 CRLATLCAQLSARADSPALC 609
C++ +CA ++ S C
Sbjct 421 CKIFQICAIMNLDVISYTDC 440
>sp|P58242|ASM3B_MOUSE Acid sphingomyelinase-like phosphodiesterase
3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1
Length=456
Score = 176 bits (447), Expect = 1e-47, Method: Compositional matrix adjust.
Identities = 131/438 (30%), Positives = 197/438 (45%), Gaps = 47/438 (11%)
Query 197 GAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPL 256
GA + R ++DLH D +Y DP P +G P AG WG+Y CD P
Sbjct 17 GAQLGRFWHISDLHLDPNYTVSKDPLQVCP-----SAGSQPVL--NAGPWGDY-LCDSPW 68
Query 257 RTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTT-VTALVRKFLGPVPV 314
+ S L + P D + WTGD H + + A+ +T L+++ V
Sbjct 69 ALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKV 128
Query 315 YPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS-- 372
Y A+GNH+ P N FP S +Y +A+ W PWL E+ + G FY+
Sbjct 129 YAALGNHDFHPKNQFPA-------QSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLP 181
Query 373 -PYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG 431
P R++ LN N N DP Q +WL L A G+ V++IGH+PPG
Sbjct 182 GPSRAGRVVVLNTNLYYSNN-EQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPG 240
Query 432 HCLK---------SWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAF 482
K S++ Y +++ ++ +A QFFGH H D F +FYD P+ V F
Sbjct 241 FFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYD--NTGAPINVMF 298
Query 483 LAPSA----TTYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
L P TT G+ NPG R+++ Y ++ + D TY LNL QAN+ P
Sbjct 299 LTPGVTPWKTTLPGVVDGANNPGIRIFE----YDRATLNLKDLVTYFLNLRQANVQ-ETP 353
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLA 593
W+ YR E Y +P+ ++ H + R+ + + Q + ++Y+ C CR+
Sbjct 354 RWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRY-YVYNSVSYNHLTCEDSCRIE 412
Query 594 TLCAQLSARADSPALCRH 611
+CA ++ A C H
Sbjct 413 HVCAIQHVAFNTYATCLH 430
>sp|Q55GC7|SGMD_DICDI Sphingomyelinase phosphodiesterase D OS=Dictyostelium
discoideum OX=44689 GN=sgmD PE=3 SV=1
Length=438
Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust.
Identities = 93/354 (26%), Positives = 150/354 (42%), Gaps = 47/354 (13%)
Query 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDV----WHQTRQDQL 295
P G +G Y CD L ++S + D + +TGD H + W +++
Sbjct 72 PTNGLYGRYG-CDTNQLLLSEVISEMLNVNSNPDFIIYTGDGAGHGLPNGPWSESQ---- 126
Query 296 RALTTVTALVRKFLGPVP---VYPAVGNHESTPVNSFPPPFIEGNHSS-RWLYEAMAKAW 351
+ L + G P P +GN++ FP + N S+ ++LYE W
Sbjct 127 ------STLAKSLYGAYPNTQFIPTIGNNDV-----FPDYNSQCNDSNLQFLYET----W 171
Query 352 EPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGE 411
W+P + + G + +SP GL +ISLN S +N DP GQ WL +
Sbjct 172 AQWIPTNQVSSFLYRGSFVVSPVSGLTIISLNTILYSVKNKNTFSTPQDPCGQFAWLEQQ 231
Query 412 LQAAEDRGDKVHIIGHIPPG----HCLKSWSWNY----YRIVARYENTLAAQFFGHTHVD 463
L AA+ G+ V+IIGHI PG + +W Y + I + Y+ T+ A FFGH H D
Sbjct 232 LIAAKQAGNSVYIIGHIFPGLDPFYLQGTWKSQYQTAFFNITSDYQTTITAGFFGHIHRD 291
Query 464 EF-EVFYDEETLSRPLAV-AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIL 521
E + +D +L+ F+ S T NP ++ + Y S + D Y
Sbjct 292 EIRSIQFDNPSLTNNHYFPMFIGSSITPVYFNNPTFKQFT----YDSQSKNITDITAYFS 347
Query 522 NLTQANIPGAIPHWQLLYRARETYGLPNTLPTA---WHNLVYRMRGDMQLFQTF 572
++ +N+ G + +W Y Y + N ++L+ RM +F +
Sbjct 348 DVYISNLKGHM-NWTEEYDFVSIYDIDNQYGIGGDQLNSLMERMVSSNSIFNNY 400
>sp|Q9C1W8|PPN1_SCHPO Endopolyphosphatase OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=ppn1 PE=3 SV=1
Length=577
Score = 85.1 bits (209), Expect = 5e-16, Method: Compositional matrix adjust.
Identities = 99/367 (27%), Positives = 157/367 (43%), Gaps = 52/367 (14%)
Query 195 APGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLC--CRRGSGLPPASRPGAGYW--GEY 249
+ G P V R L +TD+H D Y +G+ D C S P + GY G
Sbjct 40 SKGKPLVGRFLHITDMHPDIYYEKGS---TVDHYCHSYDHNSDDTPLGKSKVGYLSPGPG 96
Query 250 SKCD----LPLRTLESLLSGLGPA-GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTAL 304
+CD L +TLE L G D + WTGD HD + + Q L + L
Sbjct 97 YECDSSPALIDKTLEWLKEHQDDVLGGIDFILWTGDNSRHDNDNHFPRTQSEILASNEDL 156
Query 305 VRKFLG---PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALR 361
V K + VP+ A+GN++ P N +E SS + +A AW+ +P E
Sbjct 157 VNKMIEAFPDVPIVSAIGNNDIYPHN-----IMEAGPSS--MTRQLAGAWDALIPYEERH 209
Query 362 TLRIGGFYALSPYPG-LRLISLNMNFCSRENFWLL---INSTDPAGQL--QWLVGELQAA 415
T G +Y P L IS+N + S +N + ++ D G L +W +L+A
Sbjct 210 TFEKGSYYLCDVIPDKLAAISINTLYLSNKNAAVDGCPDDNLDEPGSLFMRWFKIQLEAY 269
Query 416 EDRGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEET 473
+G KV ++GHIPP G + ++ ++ + + + Q +GH +++ F VF + +
Sbjct 270 RLKGMKVWLLGHIPPTRGQWYEDCYTSFTDLLYEFRDIIVGQLYGHMNINHF-VFLEFDK 328
Query 474 LSRPLAVAFLAPSATTYIGLN---PGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
L P T G+ P Y ID Y+ + T+ NLT+ + G
Sbjct 329 L----------PVDTESYGIKSAQPKYVKSLIDAQYA-------ELPTFPENLTEEFLNG 371
Query 531 AIPHWQL 537
+ ++ L
Sbjct 372 TVGNYSL 378
>sp|Q9P3S1|PPN1_NEUCR Endopolyphosphatase OS=Neurospora crassa
(strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC
987) OX=367110 GN=epp-1 PE=3 SV=3
Length=731
Score = 84.7 bits (208), Expect = 8e-16, Method: Compositional matrix adjust.
Identities = 83/314 (26%), Positives = 130/314 (41%), Gaps = 42/314 (13%)
Query 202 RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLES 261
+ L +TDLH D Y + D AD C RG G P Y E S CD P + +
Sbjct 56 KFLHITDLHPDQFYKPHSSTDEAD--ACHRGKG------PAGVYGAEVSDCDSPFALINA 107
Query 262 LLSGLGP--AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLG--------- 310
+ D V WTGD HD ++ + L T + K
Sbjct 108 TFDWIAANVKDDIDFVIWTGDTARHDSDEGVPRNADQVLGTNRWIADKMAELFSDSTGRH 167
Query 311 -PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFY 369
+P+ P +GN++ P N P G +S WL + W ++P + + GG++
Sbjct 168 LEIPIVPTLGNNDILPHNILLP----GPNS--WL-QHYTHIWRRFVPEAQRHSFQFGGWF 220
Query 370 ALSPYPG-LRLISLNMNFCSRENFWL--LINSTDPA-GQLQWLVGELQAAEDRGDKVHII 425
+ P L + SLN + N + ++P Q++WL +L +RG K ++
Sbjct 221 YVEVIPNRLAIFSLNTLYFFDRNAGTDGCASPSEPGYKQMEWLRIQLHIMRERGMKAILM 280
Query 426 GHIPPGHC--LKSWS---WNYYRI-VARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
GH+PP K W W Y + + +Y + + + FGH ++D F +DE R +
Sbjct 281 GHVPPARTDSKKLWDENCWQKYSLWLRQYRDVVVSGVFGHMNIDHF-FIHDE----RDIN 335
Query 480 VAFLAPSATTYIGL 493
V LA A I +
Sbjct 336 VGQLAGLADNSIDI 349
>sp|Q5KH67|PPN1_CRYNJ Endopolyphosphatase OS=Cryptococcus neoformans
var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
OX=214684 GN=PPN1 PE=3 SV=1
Length=678
Score = 84.7 bits (208), Expect = 9e-16, Method: Compositional matrix adjust.
Identities = 69/247 (28%), Positives = 109/247 (44%), Gaps = 22/247 (9%)
Query 243 AGYWGE-YSKCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHDVWHQTRQDQLRALT 299
AG WG S CD P+ + L A D V WTGD HD+ + +
Sbjct 120 AGKWGTAVSDCDCPMSLVNITFDWLKEEWANEVDFVVWTGDNARHDIDRRIPRTPKEIFD 179
Query 300 TVTALVRKFLG----PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWL 355
+ +V + L +P+ P++GN++ P N + SR + E W+ ++
Sbjct 180 SNRMIVDRMLDAFGRDMPIVPSIGNNDIYPHN------VLAAGPSR-ITEEFLLIWKHFI 232
Query 356 PAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWL---LINSTDPAG-QLQWLVG 410
P+EA G ++++ P L +ISLN F N + +S DP ++ WL
Sbjct 233 PSEAAHVFERGAYFSVEVIPDRLAVISLNTLFWYDANTLVDGCRDHSNDPGALEMDWLEV 292
Query 411 ELQAAEDRGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVF 468
+L RG +V + GH+PP H + Y + RY++T+ FGH +VD F F
Sbjct 293 QLNNFRQRGMQVWLTGHVPPHMNHYYDNCYLRYGDLALRYQDTIVGHLFGHMNVDHF-FF 351
Query 469 YDEETLS 475
D + L
Sbjct 352 IDVDELE 358
>sp|Q6FMQ0|PPN1_CANGA Endopolyphosphatase OS=Candida glabrata
(strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL
Y-65 / CBS 138) OX=284593 GN=PPN1 PE=3 SV=1
Length=663
Score = 76.6 bits (187), Expect = 3e-13, Method: Compositional matrix adjust.
Identities = 79/289 (27%), Positives = 124/289 (43%), Gaps = 41/289 (14%)
Query 202 RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGE-YSKCDLPLRTLE 260
R L +TD+H D Y+ GT D +C SG P + A +G S CD P+ ++
Sbjct 86 RFLHITDMHPDEYYVAGT---SIDNVC---HSGEPTKGKDRAAKFGNAMSGCDSPMLLMD 139
Query 261 SLLSGLGP--AGPFDMVYWTGDIPAHD---VWHQTRQDQLRALTTVTALVRK-FLGP--- 311
L + D V WTGD HD + +T + R V ++K F P
Sbjct 140 MTLDWIDKNLKDQIDFVVWTGDNIRHDNDRTYPRTEDEIFRMNAEVAEKIKKIFRTPNSP 199
Query 312 ------VPVYPAVGNHESTPVNSFP-PPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLR 364
VPV P++GN++ P N F P ++ +R Y + W ++P E R
Sbjct 200 DPRDFAVPVVPSIGNNDVFPHNLFSLGPTLQ----TREYY----RLWGDFIPEEQQRMFD 251
Query 365 IGGFYALSPYPG-LRLISLNMNFCSRENFWLLINSTDPAGQ-----LQWLVGELQAAEDR 418
+ PG L ++S N + + N L+++ D Q L WL L +R
Sbjct 252 RDASFFTEVIPGKLAVLSFNTLYLFKAN--PLVDNCDSRKQPGYQLLLWLGYVLDEIRER 309
Query 419 GDKVHIIGHIPP-GHCLKSWSWNYYRI-VARYENTLAAQFFGHTHVDEF 465
G KV I GH+PP S ++ + + + Y + + +GH ++D F
Sbjct 310 GMKVWISGHVPPIAKNYDSSCYDKFSLWMHEYRDVIIGGLYGHMNMDHF 358
>sp|Q6BKG0|PPN1_DEBHA Endopolyphosphatase OS=Debaryomyces hansenii
(strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 /
NBRC 0083 / IGC 2968) OX=284592 GN=PPN1 PE=3 SV=3
Length=713
Score = 70.1 bits (170), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 80/312 (26%), Positives = 125/312 (40%), Gaps = 54/312 (17%)
Query 184 PKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGA 243
PKP K R L +TD+H D Y G D C G G A + G
Sbjct 78 PKPKLKIVKGGDEQVLHGRFLHITDMHPDKYYKTGADVGS----LCHSGKG--SAGKYGD 131
Query 244 GYWGEYSKCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHD---VWHQTRQDQLRAL 298
G CD P+ +E L + D V WTGD HD + +T +
Sbjct 132 AVLG----CDSPMVLMEDTLKWVKENLKDKIDFVVWTGDNVRHDNDRRYPRTESNIFDMN 187
Query 299 TTVTALVRKFLG------------PVPVYPAVGNHESTPVNSFPP-PFIEGNHSSRWLYE 345
V+ L+ + +P+ P++GN++ P N F P P ++ +R L+
Sbjct 188 QRVSELMYETFKEENPRGGRPRQLKIPLVPSLGNNDVFPHNLFSPGPTLQ----TRELF- 242
Query 346 AMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWLLIN---STDP 401
K W ++PA L G ++ P L ++S+N + + N L+ N DP
Sbjct 243 ---KIWHDFVPAAQLHIFNRGAYFFKEIIPNELAVLSINTLYLFQSN-PLVDNCDRKKDP 298
Query 402 AGQL-QWLVGELQAAEDRGDKVHIIGHIPPGH------CLKSW-SWNYYRIVARYENTLA 453
+L +WL L+ R KV + GH+PP CL+ + W + Y + +
Sbjct 299 GHKLFEWLGYTLKEMRARNMKVWLSGHVPPNEKNYDISCLRKYIVW-----MHEYRDVII 353
Query 454 AQFFGHTHVDEF 465
+GH ++D F
Sbjct 354 GGLYGHMNIDHF 365
>sp|Q756F2|PPN1_EREGS Endopolyphosphatase OS=Eremothecium gossypii
(strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OX=284811 GN=PPN1 PE=3 SV=2
Length=594
Score = 65.9 bits (159), Expect = 7e-10, Method: Compositional matrix adjust.
Identities = 76/291 (26%), Positives = 113/291 (39%), Gaps = 46/291 (16%)
Query 202 RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGE-YSKCDLPLRTLE 260
R L +TD+H D Y+EG+ A C + R AG +G+ CD P+ +
Sbjct 70 RFLHITDIHPDPLYVEGSSIAGA----CHGDPARDASDR--AGRFGDAMGGCDAPMDLMN 123
Query 261 SLLSGLGP--AGPFDMVYWTGDIPAHD-----------VWHQTRQ--DQLRALTTVTALV 305
L+ + D V WTGD HD + H Q DQ L
Sbjct 124 YTLAWVATHLRDEIDFVVWTGDNARHDNDRRQPRTAEQILHMNAQVADQFYELFQQQRDG 183
Query 306 RKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRI 365
G VPV P++GN++ P N F + + + + W ++P E +
Sbjct 184 DTMQG-VPVVPSLGNNDVFPHNMF-------SLGPTLMTRQLQRIWAKFIPEEQRQAFEH 235
Query 366 GGFYALSPYPG-LRLISLNMNFCSRENFWLLINSTDPA----GQLQWLVGELQAAEDRGD 420
+ + P L +IS N + + N L+ N D A L WL L+ R
Sbjct 236 DTSFFVEVIPDRLAVISFNTLYFFKSNP-LVDNCNDKAQPGHALLLWLGSVLEEMRARNM 294
Query 421 KVHIIGHIPP------GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEF 465
KV + GH+PP G C +W Y Y + + +GH +VD F
Sbjct 295 KVWLSGHVPPIPKNFEGSCYNKLAWWTY----EYRDVIIGGLYGHMNVDHF 341
>sp|Q6CWT7|PPN1_KLULA Endopolyphosphatase OS=Kluyveromyces lactis
(strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL
Y-1140 / WM37) OX=284590 GN=PPN1 PE=3 SV=1
Length=681
Score = 65.5 bits (158), Expect = 1e-09, Method: Compositional matrix adjust.
Identities = 86/315 (27%), Positives = 125/315 (40%), Gaps = 46/315 (15%)
Query 179 SLPTVPKPPPKPPSPPAPGAPVS-RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPP 237
SL P P K + R L +TD+H D Y E T D C RG P
Sbjct 87 SLGLTPNQPVKITDIGGKEKSIKGRFLHITDMHPDLYYKENTSIDD----TCHRGK--PK 140
Query 238 ASRPGAGYWGEYSK-CDLP----LRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQ--- 289
A +G K CD P TL+ + L + D + WTGD HD +
Sbjct 141 NDGDRAARFGNAMKGCDGPPDLMYYTLDWIHKNL--SDEIDFIIWTGDNVRHDNDRRIPR 198
Query 290 TRQDQLRALTTVTALVRKFLG----------PVPVYPAVGNHESTPVNSFPP-PFIEGNH 338
T Q V+ L K V + P++GN++ P N F P P ++
Sbjct 199 TEQQIFDMNRQVSELFLKTFKDHESDDPRDLKVKIIPSLGNNDVFPHNLFSPGPTLQ--- 255
Query 339 SSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWLLIN 397
+R LY+ W ++P T + + PG L +ISLN + + N L++
Sbjct 256 -TRELYDI----WSQFIPPAQQNTFDRYASFFVEAIPGKLAVISLNTLYMFKGN--PLVD 308
Query 398 STDPAGQ-----LQWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSWSWNYYRIVARYEN 450
+ Q L W+ LQ DRG KV + GH+P P + S S + Y +
Sbjct 309 NCSNKKQPGYKMLLWVGFTLQELRDRGMKVWLSGHVPPIPKNFDSSCSDKLALWLHEYSD 368
Query 451 TLAAQFFGHTHVDEF 465
+ F+GH ++D F
Sbjct 369 IIIGGFYGHMNMDHF 383
>sp|Q04119|PPN1_YEAST Endopolyphosphatase OS=Saccharomyces cerevisiae
(strain ATCC 204508 / S288c) OX=559292 GN=PPN1 PE=1
SV=1
Length=674
Score = 63.9 bits (154), Expect = 3e-09, Method: Compositional matrix adjust.
Identities = 73/291 (25%), Positives = 124/291 (43%), Gaps = 45/291 (15%)
Query 202 RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGE-YSKCDLPLRTLE 260
R L +TD+H D Y+EG+ D +C +G P + A +G+ S CD P+ +E
Sbjct 96 RFLHITDIHPDPYYVEGS---SIDAVC---HTGKPSKKKDVAPKFGKAMSGCDSPVILME 149
Query 261 SLLSGLGPA--GPFDMVYWTGDIPAHD--VWHQTRQDQLRALTTVTA--LVRKFLG---- 310
L + D V WTGD HD H + Q+ + + A + F
Sbjct 150 ETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTEAQIFDMNNIVADKMTELFSAGNEE 209
Query 311 -----PVPVYPAVGNHESTPVNSFP-PPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLR 364
V V P++GN++ P N F P ++ +R Y + W+ ++P + RT
Sbjct 210 DPRDFDVSVIPSLGNNDVFPHNMFALGPTLQ----TREYY----RIWKNFVPQQQQRTFD 261
Query 365 IGGFYALSPYPG-LRLISLNMNFCSRENFWLLINSTDPAGQ-----LQWLVGELQAAEDR 418
+ PG L ++S+N + + N L+++ + + L W L+ R
Sbjct 262 RSASFLTEVIPGKLAVLSINTLYLFKAN--PLVDNCNSKKEPGYQLLLWFGYVLEELRSR 319
Query 419 GDKVHIIGHIPPGHCLKSWSWNYYRIVA----RYENTLAAQFFGHTHVDEF 465
G KV + GH+PP K++ + Y Y + + +GH ++D F
Sbjct 320 GMKVWLSGHVPP--IAKNFDQSCYDKFTLWTHEYRDIIIGGLYGHMNIDHF 368
>sp|Q6CEE7|PPN1_YARLI Endopolyphosphatase OS=Yarrowia lipolytica
(strain CLIB 122 / E 150) OX=284591 GN=PPN1 PE=3 SV=1
Length=747
Score = 53.9 bits (128), Expect = 4e-06, Method: Compositional matrix adjust.
Identities = 67/266 (25%), Positives = 99/266 (37%), Gaps = 53/266 (20%)
Query 241 PGAGYWGE-YSKCDLPLRTLESLLSGLGPA--GPFDMVYWTGDIPAHDV---WHQTRQDQ 294
P AGY+G S CD P+ + + + D + WTGD HD + + QD
Sbjct 114 PKAGYYGHPLSSCDGPISLMNATFDWIDQNIRDEIDFIIWTGDNVRHDNDNRYPRLEQDI 173
Query 295 LRALTTVTALVRKFLG--------------------PVPVYPAVGNHESTPVNSF--PPP 332
V++ + +P+ P++GN++ P N + P
Sbjct 174 FGYNQIVSSKFHELFRYNETRDGEGHNGGGDPQHPLVIPIIPSLGNNDVFPHNLYLAGPS 233
Query 333 FIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSREN 391
F S R M + W ++P G +Y G L +ISLN + + N
Sbjct 234 F----QSRR-----MLQIWSEFVPEAQQHIFSRGSYYFQEVITGKLAVISLNTLYFYKSN 284
Query 392 FWL--LINSTDPA-GQLQWLVGELQAAEDRGDKVHIIGHIPP------GHC-LKSWSWNY 441
TDP L WL L RG KV + GH+PP C LK W
Sbjct 285 PMSDGCDEKTDPGYKHLVWLGVVLDEMRQRGMKVWLSGHVPPVEKNYEDSCHLKLAYW-- 342
Query 442 YRIVARYENTLAAQFFGHTHVDEFEV 467
+ Y + + FGH ++D F V
Sbjct 343 ---LTEYRDIIVGSVFGHMNIDHFVV 365
>sp|Q75EN9|CCZ1_EREGS Vacuolar fusion protein CCZ1 OS=Eremothecium
gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 /
NRRL Y-1056) OX=284811 GN=CCZ1 PE=3 SV=1
Length=663
Score = 35.8 bits (81), Expect = 1.3, Method: Compositional matrix adjust.
Identities = 22/74 (30%), Positives = 30/74 (41%), Gaps = 6/74 (8%)
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSK------CDLPLRTLES 261
D WD DYL+ D D + GS + ++PG +G ++K C LPL
Sbjct 407 DKIWDPDYLQAIDAKLYDAMLQLEGSVVTEDNKPGRFAYGVFNKTTKRIECSLPLLRFSD 466
Query 262 LLSGLGPAGPFDMV 275
S P MV
Sbjct 467 KRSDEKSRQPLKMV 480
>sp|B0SUK3|THIE_CAUSK Thiamine-phosphate synthase OS=Caulobacter
sp. (strain K31) OX=366602 GN=thiE PE=3 SV=1
Length=219
Score = 35.0 bits (79), Expect = 1.3, Method: Compositional matrix adjust.
Identities = 32/110 (29%), Positives = 49/110 (45%), Gaps = 19/110 (17%)
Query 72 RLHRIVP-RLRDVFGWG-NLTCPICKGLFTAINLGLKKEPN------------VARVGSV 117
RL+ I P L D+ +G +L + G A+ + LK P+ +AR V
Sbjct 5 RLYLITPPALDDLAAFGHDLAAALDGGDVAALQIRLKDAPDDIIAAAVQVLSPIARARDV 64
Query 118 AIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTC 167
A+ L + +A C VHL +DDM R ++ P G ++G TC
Sbjct 65 AVILNDRPDLAARLGCDG-VHLGQDDMPLAQARKLMGP----GAMIGVTC 109
>sp|Q8H5F8|ADPRM_ORYSJ Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Oryza sativa subsp. japonica OX=39947 GN=Os07g0688000
PE=2 SV=1
Length=321
Score = 34.7 bits (78), Expect = 2.6, Method: Compositional matrix adjust.
Identities = 33/110 (30%), Positives = 44/110 (40%), Gaps = 16/110 (15%)
Query 393 WLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIP--PGHC-LKSWSWNYYRIVA--R 447
+++ N QL WL LQ A R V + H+P PG + WNY ++A R
Sbjct 192 FVMFNGGVGKEQLSWLNDVLQDASARRQNVILCSHLPMDPGSASFAALMWNYDEVMAIVR 251
Query 448 YENTLAAQFFGHTH-----VDEFEVFYDEETLSRPLAVAFLAPSATTYIG 492
+ A F GH H VD V + R L A P T+ G
Sbjct 252 QYKCVKACFAGHDHKGGHSVDSHGVHH------RTLEAALECPPGTSAFG 295
>sp|Q99NB2|B3GN5_RAT Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
OS=Rattus norvegicus OX=10116 GN=B3gnt5
PE=2 SV=2
Length=377
Score = 33.9 bits (76), Expect = 4.3, Method: Compositional matrix adjust.
Identities = 16/60 (27%), Positives = 24/60 (40%), Gaps = 0/60 (0%)
Query 52 SRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNV 111
R++W H + Q H + + FGW N CP + L TA + PN+
Sbjct 143 KRLIWEDQVYHDIIQQDFTDSFHNLTFKFLLQFGWANTFCPHARFLMTADDDIFIHMPNL 202
>sp|Q9SB68|ADPRM_ARATH Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Arabidopsis thaliana OX=3702 GN=At4g24730
PE=2 SV=1
Length=311
Score = 33.5 bits (75), Expect = 5.5, Method: Compositional matrix adjust.
Identities = 30/96 (31%), Positives = 43/96 (45%), Gaps = 10/96 (10%)
Query 404 QLQWLVGELQAAEDRGDKVHIIGHIP--PGHCLK-SWSWNY---YRIVARYENTLAAQFF 457
QLQWL LQ A + +V + GH+P PG K + WN+ I+ +Y+ ++
Sbjct 195 QLQWLDSVLQDASNSNQRVIVCGHVPMSPGVASKAALLWNFDEVMNIIHKYD-SVKVCLS 253
Query 458 GHTHVDEFEVFYDEETL-SRPLAVAFLAPSATTYIG 492
GH H + F D + R L A P T G
Sbjct 254 GHDHKGGY--FVDSHGVHHRSLEAALECPPGTYSFG 287
>sp|P26779|SAP_BOVIN Prosaposin OS=Bos taurus OX=9913 GN=PSAP
PE=1 SV=3
Length=525
Score = 33.5 bits (75), Expect = 7.9, Method: Compositional matrix adjust.
Identities = 26/98 (27%), Positives = 42/98 (43%), Gaps = 7/98 (7%)
Query 62 HPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKL 121
H S +G PA R++PR F C +CK L ++ L+K ++ + K
Sbjct 387 HLCSSRGLPAATVRVMPRKDGGF------CEVCKKLVGYLDRNLEKNSTKEQILAALEKG 440
Query 122 CNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEAC 159
C+ L C V +E ++E+ V+ PS C
Sbjct 441 CSFLPDQYRKQCDQFVTEYEPVLIEILVE-VMDPSFVC 477
>sp|Q03L46|METE_STRTD 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase OS=Streptococcus thermophilus
(strain ATCC BAA-491 / LMD-9) OX=322159 GN=metE PE=3 SV=1
Length=749
Score = 33.1 bits (74), Expect = 9.9, Method: Compositional matrix adjust.
Identities = 17/48 (35%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query 434 LKSW-SWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
+K W + NY+ IV ++E T A + GH DE++ D +RP+ V
Sbjct 112 MKKWFNTNYHYIVPKFEKTTAVKLAGHKIFDEYQEAKDLGLDTRPVVV 159
Lambda K H a alpha
0.322 0.139 0.468 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 68951548263
Results from round 2
Query= sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapiens
OX=9606 GN=SMPD1 PE=1 SV=5
Length=631
Score E
Sequences producing significant alignments: (Bits) Value
Sequences used in model and found again:
sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapie... 897 0.0
sp|Q0VD19|ASM_BOVIN Sphingomyelin phosphodiesterase OS=Bos taurus... 867 0.0
sp|Q04519|ASM_MOUSE Sphingomyelin phosphodiesterase OS=Mus muscul... 864 0.0
sp|Q23498|ASM2_CAEEL Sphingomyelin phosphodiesterase 2 OS=Caenorh... 666 0.0
sp|Q9UAY4|ASM3_CAEEL Putative sphingomyelin phosphodiesterase asm... 609 0.0
sp|Q10916|ASM1_CAEEL Sphingomyelin phosphodiesterase 1 OS=Caenorh... 604 0.0
sp|Q54C16|SGMB_DICDI Sphingomyelin phosphodiesterase B OS=Dictyos... 564 0.0
sp|Q55C09|SGMA_DICDI Sphingomyelin phosphodiesterase A OS=Dictyos... 552 0.0
sp|Q641Z7|ASM3A_RAT Cyclic GMP-AMP phosphodiesterase SMPDL3A OS=R... 473 2e-161
sp|Q92484|ASM3A_HUMAN Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 469 5e-160
sp|P70158|ASM3A_MOUSE Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 468 8e-160
sp|Q3ZC91|ASM3A_BOVIN Cyclic GMP-AMP phosphodiesterase SMPDL3A OS... 465 2e-158
sp|Q92485|ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesteras... 458 2e-155
sp|P58242|ASM3B_MOUSE Acid sphingomyelinase-like phosphodiesteras... 441 6e-149
sp|Q54SR8|SGMC_DICDI Sphingomyelinase phosphodiesterase C OS=Dict... 426 2e-143
sp|Q9C1W8|PPN1_SCHPO Endopolyphosphatase OS=Schizosaccharomyces p... 315 2e-98
sp|Q6FMQ0|PPN1_CANGA Endopolyphosphatase OS=Candida glabrata (str... 317 3e-98
sp|Q6BKG0|PPN1_DEBHA Endopolyphosphatase OS=Debaryomyces hansenii... 313 4e-96
sp|Q55GC7|SGMD_DICDI Sphingomyelinase phosphodiesterase D OS=Dict... 304 5e-96
sp|Q6CWT7|PPN1_KLULA Endopolyphosphatase OS=Kluyveromyces lactis ... 310 2e-95
sp|Q04119|PPN1_YEAST Endopolyphosphatase OS=Saccharomyces cerevis... 308 7e-95
sp|Q5KH67|PPN1_CRYNJ Endopolyphosphatase OS=Cryptococcus neoforma... 302 2e-92
sp|Q756F2|PPN1_EREGS Endopolyphosphatase OS=Eremothecium gossypii... 296 5e-91
sp|Q9P3S1|PPN1_NEUCR Endopolyphosphatase OS=Neurospora crassa (st... 295 2e-89
sp|Q6CEE7|PPN1_YARLI Endopolyphosphatase OS=Yarrowia lipolytica (... 277 5e-82
Sequences not found previously or not previously below threshold:
sp|P07602|SAP_HUMAN Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE... 53.2 6e-06
sp|P10960|SAP_RAT Prosaposin OS=Rattus norvegicus OX=10116 GN=Psa... 51.7 2e-05
sp|Q61207|SAP_MOUSE Prosaposin OS=Mus musculus OX=10090 GN=Psap P... 50.9 3e-05
sp|Q9SB68|ADPRM_ARATH Manganese-dependent ADP-ribose/CDP-alcohol ... 50.1 3e-05
sp|P20097|SAP_CAVPO Saposin-C OS=Cavia porcellus OX=10141 GN=PSAP... 45.9 3e-05
sp|P38887|YH02_YEAST Uncharacterized protein YHR202W OS=Saccharom... 50.5 4e-05
sp|Q8C1C1|SAPL1_MOUSE Proactivator polypeptide-like 1 OS=Mus musc... 50.1 4e-05
sp|Q28FE0|CPPED_XENTR Serine/threonine-protein phosphatase CPPED1... 49.4 5e-05
sp|P26779|SAP_BOVIN Prosaposin OS=Bos taurus OX=9913 GN=PSAP PE=1... 48.6 1e-04
sp|O13035|SAP_CHICK Prosaposin OS=Gallus gallus OX=9031 GN=PSAP P... 47.4 3e-04
sp|Q5U3W0|CPPED_DANRE Serine/threonine-protein phosphatase CPPED1... 45.9 7e-04
sp|Q5RCR9|CPPED_PONAB Serine/threonine-protein phosphatase CPPED1... 45.9 7e-04
sp|Q3LIE5|ADPRM_HUMAN Manganese-dependent ADP-ribose/CDP-alcohol ... 45.5 0.001
sp|Q8BFS6|CPPED_MOUSE Serine/threonine-protein phosphatase CPPED1... 44.7 0.001
sp|Q9BRF8|CPPED_HUMAN Serine/threonine-protein phosphatase CPPED1... 44.0 0.003
sp|A7YY53|ADPRM_BOVIN Manganese-dependent ADP-ribose/CDP-alcohol ... 42.4 0.009
sp|Q99KS6|ADPRM_MOUSE Manganese-dependent ADP-ribose/CDP-alcohol ... 42.4 0.009
sp|Q76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with th... 42.8 0.012
sp|Q6NUJ1|SAPL1_HUMAN Proactivator polypeptide-like 1 OS=Homo sap... 41.7 0.019
sp|Q7T0Q0|ADPRM_XENLA Manganese-dependent ADP-ribose/CDP-alcohol ... 40.9 0.026
sp|Q5M886|ADPRM_RAT Manganese-dependent ADP-ribose/CDP-alcohol di... 40.9 0.031
sp|Q66JJ3|ADPRM_XENTR Manganese-dependent ADP-ribose/CDP-alcohol ... 40.5 0.040
sp|Q58DC0|CPPED_BOVIN Serine/threonine-protein phosphatase CPPED1... 40.1 0.041
sp|Q8H5F8|ADPRM_ORYSJ Manganese-dependent ADP-ribose/CDP-alcohol ... 40.1 0.047
sp|Q29075|NKL_PIG Antimicrobial peptide NK-lysin (Fragment) OS=Su... 37.8 0.072
sp|P9WL81|Y2577_MYCTU Uncharacterized protein Rv2577 OS=Mycobacte... 39.7 0.092
sp|P9WL80|Y2577_MYCTO Uncharacterized protein MT2654 OS=Mycobacte... 39.7 0.092
sp|B2W0D9|STS1_PYRTR Tethering factor for nuclear proteasome sts1... 38.2 0.16
sp|O59759|YJM5_SCHPO Uncharacterized protein C1020.05 OS=Schizosa... 38.6 0.19
sp|E3RPB1|STS1_PYRTT Tethering factor for nuclear proteasome sts1... 37.4 0.34
sp|A2RSY6|TRM1L_MOUSE TRMT1-like protein OS=Mus musculus OX=10090... 37.4 0.44
sp|Q08I43|ERI1_SCHPO 3'-5' exonuclease eri1 OS=Schizosaccharomyce... 37.0 0.50
sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein B OS... 37.0 0.56
sp|Q8H129|PPA3_ARATH Purple acid phosphatase 3 OS=Arabidopsis tha... 36.6 0.56
sp|Q7T291|ADPRM_DANRE Manganese-dependent ADP-ribose/CDP-alcohol ... 35.9 1.1
sp|E7QJD3|YIM1_YEASZ Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|E7LYS5|YIM1_YEASV Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|E7KGT3|YIM1_YEASA Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|C8ZF09|YIM1_YEAS8 Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|B5VPS4|YIM1_YEAS6 Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|C7GQ91|YIM1_YEAS2 Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|B3LM39|YIM1_YEAS1 Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.9 1.2
sp|Q9SCX8|PPA17_ARATH Purple acid phosphatase 17 OS=Arabidopsis t... 35.5 1.5
sp|A6ZML0|YIM1_YEAS7 Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.1 2.0
sp|P28625|YIM1_YEAST Protein YIM1 OS=Saccharomyces cerevisiae (st... 35.1 2.0
sp|E7NLM5|YIM1_YEASO Protein YIM1 OS=Saccharomyces cerevisiae (st... 34.0 4.7
sp|A5WBU9|CNPD3_PSYWF Probable cyclic nucleotide phosphodiesteras... 34.0 4.8
sp|Q05904|SM34_LYTPI 34 kDa spicule matrix protein OS=Lytechinus ... 33.2 7.9
>sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapiens
OX=9606 GN=SMPD1 PE=1 SV=5
Length=631
Score = 897 bits (2317), Expect = 0.0, Method: Composition-based stats.
Identities = 631/631 (100%), Positives = 631/631 (100%), Gaps = 0/631 (0%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE
Sbjct 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
Query 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK
Sbjct 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
Query 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL
Sbjct 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
Query 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR
Sbjct 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
Query 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT
Sbjct 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
Query 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL
Sbjct 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
Query 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
Sbjct 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
Query 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV
Sbjct 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
Query 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR
Sbjct 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
Query 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
Sbjct 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
Query 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
ARADSPALCRHLMPDGSLPEAQSLWPRPLFC
Sbjct 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
>sp|Q0VD19|ASM_BOVIN Sphingomyelin phosphodiesterase OS=Bos taurus
OX=9913 GN=SMPD1 PE=2 SV=1
Length=625
Score = 867 bits (2239), Expect = 0.0, Method: Composition-based stats.
Identities = 535/631 (85%), Positives = 569/631 (90%), Gaps = 6/631 (1%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE 60
MPR+G S Q PRSGREQ D + GAP + L L LALALAL +S VLW+PAE
Sbjct 1 MPRHGVSPGQGLPRSGREQASDRSLGAP------CLRLLWLGLALALALPNSPVLWSPAE 54
Query 61 AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK 120
A PL QGHPA+ RI P+L++ FGW NLTCP CKGLFTAI+ GL+ + +VA VGSVAIK
Sbjct 55 ARPLPTQGHPAKFIRIAPQLQEAFGWWNLTCPTCKGLFTAIDFGLRNQASVAWVGSVAIK 114
Query 121 LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL 180
LC LLKIAPPAVCQS V LFEDDMVEVW RSVLSPSEACGLLLGS+CGHWDIFSSWNISL
Sbjct 115 LCVLLKIAPPAVCQSAVQLFEDDMVEVWTRSVLSPSEACGLLLGSSCGHWDIFSSWNISL 174
Query 181 PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR 240
P VPKPPP+PP PPAPG+PVSR+LFLTDLHWDHDYLEGTDP+C +PLCCRR SG PPAS+
Sbjct 175 PAVPKPPPQPPKPPAPGSPVSRVLFLTDLHWDHDYLEGTDPNCENPLCCRRDSGPPPASQ 234
Query 241 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT 300
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAH++W Q+RQDQLRALTT
Sbjct 235 PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHNIWQQSRQDQLRALTT 294
Query 301 VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL 360
+TALV+KFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS WLYEAMA+AWEPWLPAEAL
Sbjct 295 ITALVKKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSHWLYEAMAEAWEPWLPAEAL 354
Query 361 RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
RTLRIGGFYALSP PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
Sbjct 355 RTLRIGGFYALSPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 414
Query 421 KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV 480
KVHIIGHIPPGHCLKSWSWNYYRIV RYENTLA QFFGHTHVDEFEVFYDEETLSRPL+V
Sbjct 415 KVHIIGHIPPGHCLKSWSWNYYRIVERYENTLAGQFFGHTHVDEFEVFYDEETLSRPLSV 474
Query 481 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYI+NLT+AN PGA PHW LLYR
Sbjct 475 AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIMNLTEANEPGATPHWYLLYR 534
Query 541 ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 600
ARETYGLPN LPTAWH+LVYRMR D QLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
Sbjct 535 ARETYGLPNALPTAWHDLVYRMRKDTQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS 594
Query 601 ARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
AR+DSPALCRHL+PD SLP+ QSLW PL C
Sbjct 595 ARSDSPALCRHLVPDASLPDVQSLWSMPLLC 625
>sp|Q04519|ASM_MOUSE Sphingomyelin phosphodiesterase OS=Mus musculus
OX=10090 GN=Smpd1 PE=1 SV=2
Length=627
Score = 864 bits (2232), Expect = 0.0, Method: Composition-based stats.
Identities = 519/633 (82%), Positives = 556/633 (88%), Gaps = 8/633 (1%)
Query 1 MPRYGASLRQSCPRSGREQGQDGTAGAP--GLLWMGLVLALALALALALALSDSRVLWAP 58
MP + AS Q R+G EQ + + AP GLLWMGL LAL LAL DS VLW P
Sbjct 1 MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWMGLGLAL------VLALFDSTVLWVP 54
Query 59 AEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVA 118
A A+PL +GH + I P L+ FGW NLTCP CK LFTA+N GLKKEPNVARVGSVA
Sbjct 55 ARAYPLPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVA 114
Query 119 IKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNI 178
IK+C +L IAP VCQS VHLFEDD+VEVW RSVLSPSEACGLLLGS+CGHWDIFS+WNI
Sbjct 115 IKICKMLNIAPLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNI 174
Query 179 SLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPA 238
SLP+VPKPPPKPPSPPAPGAPVSR+LFLTDLHWDH+YLEGTDP CADPLCCRRGSG PP
Sbjct 175 SLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPN 234
Query 239 SRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRAL 298
S+ GAG+WGEYSKCDLPLRTLESLL GLGPAGPF+MVYWTGDIPAHDVW Q+RQDQLRAL
Sbjct 235 SQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRAL 294
Query 299 TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAE 358
TT+T LVRKFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS+WLYEAMAKAWEPWLPA+
Sbjct 295 TTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPAD 354
Query 359 ALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDR 418
AL TLRIGGFYAL+P PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLV ELQAAE+R
Sbjct 355 ALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENR 414
Query 419 GDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPL 478
GDKVHIIGHIPPGHCLKSWSWNYY+I+ARYENTLA QFFGHTHVDEFE+FYDEETLSRPL
Sbjct 415 GDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPL 474
Query 479 AVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLL 538
AVAFLAPSATT+I LNPGYRVYQIDGNY GSSHVVLDHETYILNLTQAN G P W+ L
Sbjct 475 AVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRL 534
Query 539 YRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ 598
YRARETYGLP+ +P +WHNLVYRMR D QLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ
Sbjct 535 YRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQ 594
Query 599 LSARADSPALCRHLMPDGSLPEAQSLWPRPLFC 631
LSARADSPALCRHLMP+GSLP+A LW RPL C
Sbjct 595 LSARADSPALCRHLMPNGSLPDANRLWSRPLLC 627
>sp|Q23498|ASM2_CAEEL Sphingomyelin phosphodiesterase 2 OS=Caenorhabditis
elegans OX=6239 GN=asm-2 PE=1 SV=3
Length=618
Score = 666 bits (1718), Expect = 0.0, Method: Composition-based stats.
Identities = 216/615 (35%), Positives = 329/615 (53%), Gaps = 41/615 (7%)
Query 35 LVLALALALALALALSDSRVLWAPAEAHPL----SPQGHPA-------RLHRIVPRLRDV 83
++L + + LAL + +S VL P + H + +G+ A ++ R + +
Sbjct 6 IILGIGIVLALVSNV-ESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINE 64
Query 84 FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDD 143
++C C + + + + + + LC+L + P VC++I++ F+D+
Sbjct 65 PENRKMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKDE 124
Query 144 MVEVWRRSVLSPSEACGLLLGSTCGHWD--IFSSWNISLPTVPKPPPKPPSPPAPGAPVS 201
+V V RSV +P E CG + + CGH D + WNI++P KPP KP P
Sbjct 125 VVFVLERSVFTPEEICGAFIAN-CGHSDKPLTHMWNITIPG-GKPPIKPWPKIPDNKPTF 182
Query 202 RILFLTDLHWDHDYLEGTDPDC-------ADPLCCRRGS----GLPPASRPG-----AGY 245
++L L+D+H DH Y+ GT+ C +CCR S G P + AG
Sbjct 183 KVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVPAGP 242
Query 246 WGEYSKCDLPLRTLESLLSGLGPA-GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTAL 304
WG CDLP +T ES + + D + TGD AHD W T + +T +
Sbjct 243 WGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNV 302
Query 305 VRKFLGPVPVYPAVGNHESTPVNSFPPPFIE--GNHSSRWLYEAMAKAWEPWLPAEALRT 362
++ VPVY ++GNHE P ++ P + +WLY+ M++ W W+P EAL T
Sbjct 303 FLEYFPGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDT 362
Query 363 LRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKV 422
++ YA+ P PGL+LISLN +CS NF+L +N DP L+WL+ ELQ +E++G+ V
Sbjct 363 VQYRASYAVYPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELV 422
Query 423 HIIGHIPPG--HCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYD-EETLSRPLA 479
HII HIPPG +CLK WSWN++ IV RYENT+A F+GHTH D+F V+YD ++ RP
Sbjct 423 HIISHIPPGDNYCLKGWSWNFFEIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFH 482
Query 480 VAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLY 539
+++PS TTY LNP YR+Y+IDG Y G+++ V D +TY N+T+AN+ P W L Y
Sbjct 483 FNWISPSLTTYDWLNPAYRIYEIDGGYEGATYTVKDAKTYFANVTEANMKNKEPEWVLSY 542
Query 540 RARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGT--PCRLATLCA 597
RE Y + + P +W +L ++ + LF+ + LY++ H +E C T CR +C
Sbjct 543 DTREHYQMADFSPQSWSDLSDKLWTNTTLFRDYVRLYYRNHYNNE-CYTDYKCRYTFVCD 601
Query 598 QLSARADSPALCRHL 612
R+ + C HL
Sbjct 602 IKKGRSYDESFCDHL 616
>sp|Q9UAY4|ASM3_CAEEL Putative sphingomyelin phosphodiesterase
asm-3 OS=Caenorhabditis elegans OX=6239 GN=asm-3 PE=3 SV=2
Length=589
Score = 609 bits (1569), Expect = 0.0, Method: Composition-based stats.
Identities = 195/549 (36%), Positives = 286/549 (52%), Gaps = 18/549 (3%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C CK + + ++ V +A+ +C I VC I+ F D+ + V ++
Sbjct 21 CEECKSIVDLLQFEWGEKKTEECVMEIAVFICETFHIEDNDVCNFIISDFSDEFMYVIKQ 80
Query 151 SVLSPSEACGLLLGSTCGHW--DIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTD 208
+++P + CGLL+ + CG + + + WN+++P +PP P PG P R L LTD
Sbjct 81 ILVTPHQLCGLLMKNDCGDFVDPLATIWNMTIPG-NQPPFVPKQVVPPGNPTLRALHLTD 139
Query 209 LHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPG-----AGYWGEYSKCDLPLRTLESLL 263
LH D Y G + DC P CCR G AG WG CD P L ++L
Sbjct 140 LHVDMFYTVGLEADCGTPQCCRPQDMNVEIVENGDVKQPAGPWGSVGSCDTPYWLLTNML 199
Query 264 SGLG-PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHE 322
+ AG D + +GD+ +H VW T + + ++ +R + PVY AVGNHE
Sbjct 200 QNIASTAGKLDYIMVSGDLVSHTVWAYTPETHSFMVKNLSDTIRSYFPKTPVYFAVGNHE 259
Query 323 STPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISL 382
PV++ P F + WLY+AM+ AW+ W+PA+ ++L G Y Y GLR+ISL
Sbjct 260 GVPVDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEKSLEYNGCYMKKIYDGLRMISL 319
Query 383 NMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSWSWN 440
N + R NFWL IN TDP G LQWL+ +LQ AE+ GDKVHI+ HIP G L+ ++ N
Sbjct 320 NNVYGDRINFWLYINQTDPDGTLQWLINQLQDAENVGDKVHIVAHIPGSDGEALEGYALN 379
Query 441 YYRIVARYENTLAAQFFGHTHVDEFEVFYD--EETLSRPLAVAFLAPSATTYIGLNPGYR 498
YY+I+ RY NT+ QFFGHTH ++F + Y ++ S P V + APS T Y P YR
Sbjct 380 YYKIINRYANTVVGQFFGHTHSEKFYMMYANPDDYKSTPTNVVYSAPSVTPYSDYFPAYR 439
Query 499 VYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR-ARETYGLPNTLPTAWHN 557
+Y IDG + GS++ V+D+E + NLT N W++LY+ A YGL +PT ++
Sbjct 440 IYTIDGVHKGSTYQVIDYEEWFFNLTSNNANPTNVKWEVLYQSANMEYGLKGQIPTEYNQ 499
Query 558 LVYRMRGDMQLFQTFWFLYHKG--HPPSEPC-GTPCRLATLCAQLSARADSPALCRHLMP 614
++ RM+ D LF ++ +++ + PC CR LC + LC L
Sbjct 500 MIERMKTDDSLFNKYYENHNRRSIYDGRAPCNDQQCRNGYLCDARQFHQ-TQQLCTDLEG 558
Query 615 DGSLPEAQS 623
PE +
Sbjct 559 GIQKPEPKK 567
>sp|Q10916|ASM1_CAEEL Sphingomyelin phosphodiesterase 1 OS=Caenorhabditis
elegans OX=6239 GN=asm-1 PE=1 SV=2
Length=564
Score = 604 bits (1557), Expect = 0.0, Method: Composition-based stats.
Identities = 184/539 (34%), Positives = 283/539 (53%), Gaps = 21/539 (4%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFE 141
D +G+ L C C GL + + LK + + + A +C L P AVC I F
Sbjct 33 DKYGFQPL-CISCTGLISVASFFLKFDVSEPVILEFATIVCKLFAKQPWAVCDGISSQFR 91
Query 142 DDMVEVWRR-SVLSPSEACGLLLGSTCGHWD-IFSSWNISLPTVPKPPP--KPPSPPAPG 197
D+ V+RR + SPS+ CG++L D S W ++LP PK K P
Sbjct 92 DEFFYVFRRLANESPSQICGIILPDCADPTDPSESGWMVALPPKPKRTRISKKKVQKKPN 151
Query 198 APVSR---ILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDL 254
+S+ +L LTDLH D +Y ++ +C DP+CCR P + AGYWG KCD+
Sbjct 152 MSMSQNLNVLQLTDLHVDFEYKYPSEANCDDPVCCRVSVSEP---KKAAGYWGSVGKCDI 208
Query 255 PLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPV 314
P T+E++LS + DMV TGD H W + ++ L L + LV+ P+
Sbjct 209 PFWTVENMLSHINKTHMIDMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPSTPI 268
Query 315 YPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPY 374
Y A+GNHE PVNSF P ++ WLY+ PWL A +L G Y+
Sbjct 269 YWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVM 328
Query 375 PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG--H 432
GL+LI+LN FC NF+L +N +DP + W V EL +E +G++V+++ HIPPG
Sbjct 329 DGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSE 388
Query 433 CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDE--ETLSRPLAVAFLAPSATTY 490
CL+ W++NYYR++ R+ +T+AAQFFGH H+D F VFY++ S+P++V + +PS TT+
Sbjct 389 CLEGWAFNYYRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTF 448
Query 491 IGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNT 550
NP YR+Y+ID + ++D TY +L +A P W+ LY AR+ +G+ +
Sbjct 449 EYQNPAYRIYEID---PYNKFKIVDFTTYYADLEKAT-EDKKPVWEKLYSARQAHGMDDL 504
Query 551 LPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALC 609
P +W+ ++ ++ + + F+ + P C + C++ +C +S C
Sbjct 505 SPLSWNKVIQKLFTSEKKREKFYQYAFRNFSPQ--CDSTCQMQLMCNLRMGHHNSTLYC 561
>sp|Q54C16|SGMB_DICDI Sphingomyelin phosphodiesterase B OS=Dictyostelium
discoideum OX=44689 GN=sgmB PE=3 SV=1
Length=637
Score = 564 bits (1454), Expect = 0.0, Method: Composition-based stats.
Identities = 202/536 (38%), Positives = 287/536 (54%), Gaps = 30/536 (6%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C ICK + + + + + AI LC L I VC ++ LF + V
Sbjct 77 CDICKFGINQVQKMIASKQGIEDISKYAIDLCTYLHIEKAEVCNGLIPLFANMTYNVLSY 136
Query 151 SVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLH 210
++ CG + C + SS NI PKPP PP P+P +P +IL ++D+H
Sbjct 137 PTVTGEYVCGFV--GFCPYVPRNSS-NIINFPKPKPPHVPPVAPSPNSPTMKILHISDIH 193
Query 211 WDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGP-- 268
D Y G + DC +PLCCR +G P AG WG Y CD+ ++ +ES+ +
Sbjct 194 VDPVYESGMNADCGEPLCCRAPNG-PGVGEKAAGEWGHY-LCDINMKMVESMFEFIDQEF 251
Query 269 AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPV-PVYPAVGNHESTPVN 327
D+V+WTGD P HD+W QT Q+ A VT LV+K+ G V+PA+GNHES PVN
Sbjct 252 GEDIDIVFWTGDNPPHDIWEQTYDSQINASQLVTNLVKKYFGSTAKVFPAIGNHESLPVN 311
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLP-AEALRTLRIGGFYALSPYPGLRLISLNMNF 386
SFP P S W++ A++ W W+ E + L+ GG+Y L GLR+ISLNMN+
Sbjct 312 SFPLP-----PGSSWIFNALSYDWSDWVNVDEQVANLQYGGYYTLPVQSGLRVISLNMNW 366
Query 387 CSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG--HCLKSWSWNYYRI 444
C+ N +L NSTDPA LQW+V LQA+ED G+KV+++GHIPPG C+ SWS +I
Sbjct 367 CNNGNLYLAENSTDPANMLQWIVDTLQASEDIGEKVYLVGHIPPGIPDCIDSWSEQLLQI 426
Query 445 VARYENTLAAQFFGHTHVDEFEVFY---DEETLSRPL---AVAFLAPSATTYIGLNPGYR 498
V RYE+T+ A F+GHTH DEF V+Y DE S P+ V + PS TTY NP +R
Sbjct 427 VNRYEDTILASFYGHTHRDEFSVYYTQSDENDPSSPMRASNVIYTTPSVTTYQHQNPSFR 486
Query 499 VYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNL 558
++ +D N + +++ TY +L+QAN+ G P W L Y TY +PN P +
Sbjct 487 IFTVDSN----TGYLMESSTYHTDLSQANLNGK-PTWLLEYNTTNTYNIPNLTPISMDLA 541
Query 559 VYRMRGDMQLFQTFWFLYHKG--HPPSEPCGT-PCRLATLCAQLSARADSPALCRH 611
+ + + + + Y+ +P S+PC + C+L +C SA C H
Sbjct 542 IQNINSSNSMLEDYHVHYYSASPYPESKPCTSISCKLDYICKMKSAAYLKYYECIH 597
>sp|Q55C09|SGMA_DICDI Sphingomyelin phosphodiesterase A OS=Dictyostelium
discoideum OX=44689 GN=sgmA PE=3 SV=1
Length=583
Score = 552 bits (1423), Expect = 0.0, Method: Composition-based stats.
Identities = 168/565 (30%), Positives = 273/565 (48%), Gaps = 47/565 (8%)
Query 72 RLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPA 131
+L + L+C +C+ + + +KK ++ + LC K P
Sbjct 36 KLDKAAATTLQHGENIQLSCDVCQIGASLLEDFIKKNASLTEIIKGLSDLCIASKEEQPE 95
Query 132 VCQSIVHLFEDDMVEVWRRSVLSPSEACGLL-LGSTCGHW----------DIFSSWNISL 180
VC I++ + +V+V +S +PS+ CG + S G + + + +
Sbjct 96 VCTGILNNYVPIIVDVLIQSDFTPSQLCGYFKICSATGSSESSSISNSFDNEYRQESFNK 155
Query 181 PTVP---KPPPKPPSPPAP-------GAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCR 230
PT+ KP K S P + IL ++D+H+D DY G++P+C PLCCR
Sbjct 156 PTMKVNKKPQYKDLSNQEPLVKKFKGNDSIGYILQISDVHFDPDYKVGSNPNCGRPLCCR 215
Query 231 RGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGP-AGPFDMVYWTGDIPAHDVWHQ 289
G G AG G Y CD+P T+E + L D + WTGD P H+VW Q
Sbjct 216 DGVGS-------AGPIGHY-LCDIPFSTVELIFQHLATLTDQLDFIVWTGDNPPHNVWEQ 267
Query 290 TRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAK 349
++ Q A T+ +++K PV P++GNHE+ P + + P S+WL +++
Sbjct 268 SQAQQELATATLAQVIQKTFPNTPVLPSLGNHEAYPADQYVLPN------SQWLLDSIYT 321
Query 350 AWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINS--TDPAGQLQW 407
W PWL A+AL ++ G+Y PGLR++SLN NF+ L+ + P Q W
Sbjct 322 YWAPWLDADALELVKERGYYTSLIKPGLRVMSLNTLENDMINFYNLLPTYLKGPNNQSDW 381
Query 408 LVGELQAAEDRGDKVHIIGHIP---PGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDE 464
++ L+ A+ G+KV IIGHIP W Y ++V ++ + + Q +GHTH D+
Sbjct 382 MINTLEQAQSNGEKVLIIGHIPCTVKSASTDGWCAMYEQVVGQFSDVIIGQLYGHTHYDQ 441
Query 465 FEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLT 524
F VF D T + P + ++ PS TTY PGYR+YQ D S++ ++++ Y N+T
Sbjct 442 FSVFSDVATHTIPTGMNYIVPSLTTYQNHEPGYRIYQFD----YSTNQIVNYYQYHANIT 497
Query 525 QANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSE 584
+AN GA+ ++QL Y A+E Y + + PT+W + +M+ + +F ++ F P E
Sbjct 498 EANETGAL-NFQLTYSAKELYNMDDLSPTSWTKVANQMKTNSTMFNSY-FENLSSSPIKE 555
Query 585 PCGTPCRLATLCAQLSARADSPALC 609
C C+ +C + C
Sbjct 556 SCDQACQTKWICQIFGITSSEFDKC 580
>sp|Q641Z7|ASM3A_RAT Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Rattus norvegicus OX=10116 GN=Smpdl3a PE=2 SV=1
Length=445
Score = 473 bits (1216), Expect = 2e-161, Method: Composition-based stats.
Identities = 137/450 (30%), Positives = 212/450 (47%), Gaps = 46/450 (10%)
Query 186 PPPKPPSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAG 244
P P PA GAP V + +TDLH D Y TD D +G+ + G
Sbjct 19 PGLGVPLAPAYGAPAVGQFWHVTDLHLDPTY-HITD-DHTKVCASSKGANVS-----NPG 71
Query 245 YWGEYSKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQ-TRQDQLRALTTVT 302
+G+ CD P + + S + +G + WTGD P H + + + +T +T
Sbjct 72 PFGDV-LCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVRELSTGSVIEVITNMT 130
Query 303 ALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRT 362
V+ + V+PA+GNH+ P + P ++ +Y A++ W+PWL EA+ T
Sbjct 131 VTVQNLFPNLQVFPALGNHDYWPQDQLPI-------ATSKVYSAVSDLWKPWLDEEAIST 183
Query 363 LRIGGFYALSP--YPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
LR GGFY+ P LR+ISLN N N + +N TDPA Q +WL L ++ +
Sbjct 184 LRKGGFYSQKVASNPDLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLRNKE 242
Query 421 KVHIIGHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDE 471
KV++I H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 243 KVYVIAHVPVGYLPYATKTPAMRQYYNEKLVDIFRRYSSVIAGQFYGHTHRDSLMVLSDK 302
Query 472 ETLSRPLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQ 525
P+ F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+
Sbjct 303 N--GNPINSVFVAPAVTPVKGVLEKETNNPGVRLFQ----YKPGDYTLLDMLQYYLNLTE 356
Query 526 ANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSE 584
AN+ G +W L Y + YG+ + P + H L ++ D + F ++ + + S
Sbjct 357 ANLKGE-SNWTLEYTLTQAYGVADLQPKSLHGLAQQLATIDSKQFLKYYHYFFVSYDSSA 415
Query 585 PCGTPCRLATLCAQLSARADSPALC--RHL 612
PC C+ +CA ++ S C RHL
Sbjct 416 PCDQRCKTLQICAIMNLDLVSYEDCLKRHL 445
>sp|Q92484|ASM3A_HUMAN Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Homo sapiens OX=9606 GN=SMPDL3A PE=1 SV=2
Length=453
Score = 469 bits (1208), Expect = 5e-160, Method: Composition-based stats.
Identities = 129/453 (28%), Positives = 204/453 (45%), Gaps = 49/453 (11%)
Query 178 ISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPP 237
+ LP P PP + + +TDLH D Y TD D +G+
Sbjct 21 LGLPVAPAGGRNPPPA------IGQFWHVTDLHLDPTY-HITD-DHTKVCASSKGANAS- 71
Query 238 ASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQ-TRQDQL 295
G +G+ CD P + + S + +G + WTGD P H + + +
Sbjct 72 ----NPGPFGDV-LCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVI 126
Query 296 RALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWL 355
+T +T ++ + V+PA+GNH+ P + P + +Y A+A W+PWL
Sbjct 127 NVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWL 179
Query 356 PAEALRTLRIGGFYALSP--YPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQ 413
EA+ TLR GGFY+ P LR+ISLN N N + +N TDPA Q +WL L
Sbjct 180 DEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLN 238
Query 414 AAEDRGDKVHIIGHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDE 464
++ +KV+II H+P G+ + ++ I +Y + +A QF+GHTH D
Sbjct 239 NSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDS 298
Query 465 FEVFYDEETLSRPLAVAFLAPSATTY------IGLNPGYRVYQIDGNYSGSSHVVLDHET 518
V D++ P+ F+AP+ T NPG R++Q Y + +LD
Sbjct 299 IMVLSDKK--GSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQ 352
Query 519 YILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYH 577
Y LNLT+AN+ G W+L Y +TY + + P + + L + D + F ++ +
Sbjct 353 YYLNLTEANLKGE-SIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFF 411
Query 578 KGHPPSEPCGTPCRLATLCAQLSARADSPALCR 610
+ S C C+ +CA ++ S A C
Sbjct 412 VSYDSSVTCDKTCKAFQICAIMNLDNISYADCL 444
>sp|P70158|ASM3A_MOUSE Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Mus musculus OX=10090 GN=Smpdl3a PE=1 SV=2
Length=445
Score = 468 bits (1205), Expect = 8e-160, Method: Composition-based stats.
Identities = 137/450 (30%), Positives = 209/450 (46%), Gaps = 46/450 (10%)
Query 186 PPPKPPSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAG 244
P P PA AP V + +TDLH D Y D C G A+ G
Sbjct 19 PGLGVPLAPADRAPAVGQFWHVTDLHLDPTYHITDD----RTKVCASSKG---ANASNPG 71
Query 245 YWGEYSKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQ-TRQDQLRALTTVT 302
+G+ CD P + + S + +G + WTGD P H + + ++ +T +T
Sbjct 72 PFGDV-LCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMT 130
Query 303 ALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRT 362
V+ + V+PA+GNH+ P + P + +Y A+A W+PWL EA+ T
Sbjct 131 MTVQNLFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAIST 183
Query 363 LRIGGFYALSP--YPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD 420
L+ GGFY+ PGLR+ISLN N N + +N TDPA Q +WL L ++ +
Sbjct 184 LKKGGFYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKE 242
Query 421 KVHIIGHIPPGHC---------LKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDE 471
KV+II H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 243 KVYIIAHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDK 302
Query 472 ETLSRPLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQ 525
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+
Sbjct 303 N--GNPLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTE 356
Query 526 ANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSE 584
AN+ G +W L Y + Y + + P + + LV + D + F ++ Y + S
Sbjct 357 ANLKGE-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSA 415
Query 585 PCGTPCRLATLCAQLSARADSPALC--RHL 612
C C+ +CA ++ + S C +HL
Sbjct 416 TCDQHCKTLQVCAIMNLDSMSYDDCLKQHL 445
>sp|Q3ZC91|ASM3A_BOVIN Cyclic GMP-AMP phosphodiesterase SMPDL3A
OS=Bos taurus OX=9913 GN=SMPDL3A PE=2 SV=1
Length=450
Score = 465 bits (1196), Expect = 2e-158, Method: Composition-based stats.
Identities = 124/440 (28%), Positives = 197/440 (45%), Gaps = 43/440 (10%)
Query 190 PPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P +P G V + +TD H D Y D C G + G +G+
Sbjct 24 PLAPAGTGPAVGQFWHVTDFHLDPTYHITGD----HTKVCASSKGAEASD---PGPFGDV 76
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVW-HQTRQDQLRALTTVTALVRK 307
CD P R + S L + +G + WTGD P H + + +T +++
Sbjct 77 -MCDSPYRLIFSALDFIKNSGQKVSFMIWTGDSPPHVPVLELSTDKVINVTANITTTIQR 135
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL +A+ TLR GG
Sbjct 136 LFPNLQVFPALGNHDYWPQDQLPV-------VNSKVYNAVANLWKPWLTEDAITTLRKGG 188
Query 368 FYALSP--YPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 189 FYTQKVSNNPKLRIISLNTNLYYGPN-SVTLNQTDPANQFEWLENTLNISQQNKEKVYII 247
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ K + I +Y + +A QF+GHTH D V D++ +
Sbjct 248 AHVPVGYLPYARGISAMRKYHNEKLIDIFRKYSDIIAGQFYGHTHRDSIMVLSDKK--GK 305
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
P+ F+AP+ T + NPG R++Q Y + +LD Y LNLT AN+ G
Sbjct 306 PVNSLFVAPAVTPVRSVLERLTNNPGVRLFQ----YDPRDYKLLDMLQYYLNLTDANLKG 361
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMR-GDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W+L Y + Y + + P + + L + + + F ++ + + S C
Sbjct 362 E-SNWKLEYNLTQAYDIQDLQPKSLYKLAKQFAIQESKQFIKYYKYFFVSYDSSVICQGK 420
Query 590 CRLATLCAQLSARADSPALC 609
C++ +CA ++ S C
Sbjct 421 CKIFQICAIMNLDVISYTDC 440
>sp|Q92485|ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesterase
3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2
Length=455
Score = 458 bits (1177), Expect = 2e-155, Method: Composition-based stats.
Identities = 134/452 (30%), Positives = 200/452 (44%), Gaps = 49/452 (11%)
Query 194 PAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCD 253
A + + DLH D DY DP P +G P P AG WG+Y CD
Sbjct 14 GGARAEPGKFWHIADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDY-LCD 65
Query 254 LPLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQD-QLRALTTVTALVRKFLGP 311
P + S + + P D + WTGD H + + L + +T L+R+
Sbjct 66 SPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPD 125
Query 312 VPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYAL 371
VY A+GNH+ P N FP S +Y +A+ W+PWL E++ + G FY
Sbjct 126 TKVYAALGNHDFHPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCE 178
Query 372 S---PYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
P R++ LN N N L + DP Q QWL L A GD V+I+GH+
Sbjct 179 KLPGPSGAGRIVVLNTNLYYTSNA-LTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHV 237
Query 429 PPGHCLK---------SWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
PPG K ++ Y ++V ++ +A QFFGH H D F + YD+ P++
Sbjct 238 PPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDA--GVPIS 295
Query 480 VAFLAPSATTYIG---------LNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
F+ P T + NP RV++ Y ++ + D TY +NL+QAN G
Sbjct 296 AMFITPGVTPWKTTLPGVVNGANNPAIRVFE----YDRATLSLKDMVTYFMNLSQANAQG 351
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPC 590
P W+L Y+ E YG+P+ + H ++ R+ GD Q ++ +Y+ + C C
Sbjct 352 T-PRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYY-VYNSVSYSAGVCDEAC 409
Query 591 RLATLCAQLSARADSPALCRHLMPDGSLPEAQ 622
+ +CA D+ C L G+ P Q
Sbjct 410 SMQHVCAMRQVDIDAYTTC--LYASGTTPVPQ 439
>sp|P58242|ASM3B_MOUSE Acid sphingomyelinase-like phosphodiesterase
3b OS=Mus musculus OX=10090 GN=Smpdl3b PE=1 SV=1
Length=456
Score = 441 bits (1134), Expect = 6e-149, Method: Composition-based stats.
Identities = 130/446 (29%), Positives = 198/446 (44%), Gaps = 47/446 (11%)
Query 197 GAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPL 256
GA + R ++DLH D +Y DP P +G P AG WG+Y CD P
Sbjct 17 GAQLGRFWHISDLHLDPNYTVSKDPLQVCP-----SAGSQPVLN--AGPWGDY-LCDSPW 68
Query 257 RTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRAL-TTVTALVRKFLGPVPV 314
+ S L + P D + WTGD H + + A+ +T L+++ V
Sbjct 69 ALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKV 128
Query 315 YPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS-- 372
Y A+GNH+ P N FP S +Y +A+ W PWL E+ + G FY+
Sbjct 129 YAALGNHDFHPKNQFPA-------QSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLP 181
Query 373 -PYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPG 431
P R++ LN N N DP Q +WL L A G+ V++IGH+PPG
Sbjct 182 GPSRAGRVVVLNTNLYYSNN-EQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPG 240
Query 432 HCLK---------SWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAF 482
K S++ Y +++ ++ +A QFFGH H D F +FYD P+ V F
Sbjct 241 FFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYD--NTGAPINVMF 298
Query 483 LAPSATTYIG---------LNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
L P T + NPG R+++ Y ++ + D TY LNL QAN+ P
Sbjct 299 LTPGVTPWKTTLPGVVDGANNPGIRIFE----YDRATLNLKDLVTYFLNLRQANVQ-ETP 353
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLA 593
W+ YR E Y +P+ ++ H + R+ + + Q ++ +Y+ C CR+
Sbjct 354 RWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRYY-VYNSVSYNHLTCEDSCRIE 412
Query 594 TLCAQLSARADSPALCRHLMPDGSLP 619
+CA ++ A C H + +P
Sbjct 413 HVCAIQHVAFNTYATCLHGLGAKLVP 438
>sp|Q54SR8|SGMC_DICDI Sphingomyelinase phosphodiesterase C OS=Dictyostelium
discoideum OX=44689 GN=sgmC PE=3 SV=1
Length=446
Score = 426 bits (1096), Expect = 2e-143, Method: Composition-based stats.
Identities = 130/431 (30%), Positives = 202/431 (47%), Gaps = 40/431 (9%)
Query 201 SRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLE 260
+ +TD H+D Y+EG D D CR + + GA G Y KCD L+
Sbjct 32 GKFWHITDTHYDFMYIEGGDEDKQ----CREVTYKSKYEKGGASSIGNY-KCDTSFELLQ 86
Query 261 SLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQD-QLRALTTVTALVRKFLGPVPVYPAV 318
S + D + WTGD P H Q + L+++T +T L++ + +P++P++
Sbjct 87 SSFEYMVKHEEKPDFIIWTGDDPPHLGNSQLNETLVLQSITNMTNLIKGYFPDIPIFPSI 146
Query 319 GNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLR 378
GNH+S P + WL+E +A+ W P+L +++ T ++GG+Y G R
Sbjct 147 GNHDSYPQHQIGV-------GPNWLFENVAQLWSPFLSNDSIETFKLGGYYTELVSEGFR 199
Query 379 LISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWS 438
+ISLN F EN +N TDPAGQL WL L A G++V IIGH+PPG+ K
Sbjct 200 IISLNTVFYYNENRQ-CLNLTDPAGQLLWLNETLANASLAGERVWIIGHVPPGYNEKYDV 258
Query 439 WNYYR--------IVARYENTLAAQFFGHTHVDEFEVFYDEETLS----RPLAVAFLAPS 486
+N+++ ++Y + + +GH H D F +FYD+ P + FL+PS
Sbjct 259 FNFHKQFNDEYLFSFSQYSDIIEFHIYGHEHTDTFRLFYDDPNDHINDIEPTGIMFLSPS 318
Query 487 ATTYIGL-------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLY 539
T ++ NPG R+Y+ Y+ +S +LD+ + NLT I G I WQL Y
Sbjct 319 LTPWMNQFLPALPNNPGLRLYE----YNITSFALLDYYQFWTNLTDNIISGNID-WQLEY 373
Query 540 RARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQL 599
RA E + N P + + ++ F F Y+ P++ C C+ LC+
Sbjct 374 RATEFFNTFNLSPVSMYEAYLLIQSVTSQLLKFHF-YNSVSYPTKGCDEICKKIQLCSIR 432
Query 600 SARADSPALCR 610
C
Sbjct 433 HPFTKGFKECL 443
>sp|Q9C1W8|PPN1_SCHPO Endopolyphosphatase OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=ppn1 PE=3 SV=1
Length=577
Score = 315 bits (807), Expect = 2e-98, Method: Composition-based stats.
Identities = 92/365 (25%), Positives = 149/365 (41%), Gaps = 48/365 (13%)
Query 195 APGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYW--GEYSK 251
+ G P V R L +TD+H D Y +G+ D S P + GY G +
Sbjct 40 SKGKPLVGRFLHITDMHPDIYYEKGSTVDHYCH-SYDHNSDDTPLGKSKVGYLSPGPGYE 98
Query 252 CDLPLRTLESLLSGLGPA-----GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVR 306
CD ++ L L G D + WTGD HD + + Q L + LV
Sbjct 99 CDSSPALIDKTLEWLKEHQDDVLGGIDFILWTGDNSRHDNDNHFPRTQSEILASNEDLVN 158
Query 307 KF---LGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTL 363
K VP+ A+GN++ P N + +A AW+ +P E T
Sbjct 159 KMIEAFPDVPIVSAIGNNDIYPHNIM-------EAGPSSMTRQLAGAWDALIPYEERHTF 211
Query 364 RIGGFYALSPYPG-LRLISLNMNFCSRENFWLL---INSTDPAGQL--QWLVGELQAAED 417
G +Y P L IS+N + S +N + ++ D G L +W +L+A
Sbjct 212 EKGSYYLCDVIPDKLAAISINTLYLSNKNAAVDGCPDDNLDEPGSLFMRWFKIQLEAYRL 271
Query 418 RGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLS 475
+G KV ++GHIPP G + ++ ++ + + + Q +GH +++ F VF + + L
Sbjct 272 KGMKVWLLGHIPPTRGQWYEDCYTSFTDLLYEFRDIIVGQLYGHMNINHF-VFLEFDKL- 329
Query 476 RPLAVAFLAPSATTYIGLN---PGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAI 532
P T G+ P Y ID Y+ + T+ NLT+ + G +
Sbjct 330 ---------PVDTESYGIKSAQPKYVKSLIDAQYA-------ELPTFPENLTEEFLNGTV 373
Query 533 PHWQL 537
++ L
Sbjct 374 GNYSL 378
Score = 34.7 bits (78), Expect = 2.7, Method: Composition-based stats.
Identities = 12/65 (18%), Positives = 26/65 (40%), Gaps = 3/65 (5%)
Query 506 YSGSSHVVLDHETYILNLTQ--ANIPGAIPHWQLLYRARET-YGLPNTLPTAWHNLVYRM 562
Y S + + Y LN + ++LLY ++++ Y +P+ + L R+
Sbjct 465 YVPSLFTPISFKQYFLNTSNYMDATKDTEISYELLYTSKDSPYNMPDLTVPEYMRLAKRI 524
Query 563 RGDMQ 567
+
Sbjct 525 ATCDK 529
>sp|Q6FMQ0|PPN1_CANGA Endopolyphosphatase OS=Candida glabrata
(strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL
Y-65 / CBS 138) OX=284593 GN=PPN1 PE=3 SV=1
Length=663
Score = 317 bits (813), Expect = 3e-98, Method: Composition-based stats.
Identities = 78/314 (25%), Positives = 117/314 (37%), Gaps = 41/314 (13%)
Query 178 ISLPTVPKPPPKPPS--PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGL 235
ISL P+ P R L +TD+H D Y+ GT D SG
Sbjct 60 ISLGLTPRKPVVITDLRTGNKRKLHGRFLHITDMHPDEYYVAGTSIDNVC------HSGE 113
Query 236 PPASRPGAGYWGE-YSKCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHDVW---HQ 289
P + A +G S CD P+ ++ L + D V WTGD HD +
Sbjct 114 PTKGKDRAAKFGNAMSGCDSPMLLMDMTLDWIDKNLKDQIDFVVWTGDNIRHDNDRTYPR 173
Query 290 TRQDQLRALTTVTALVRKFLG----------PVPVYPAVGNHESTPVNSFPPPFIEGNHS 339
T + R V ++K VPV P++GN++ P N F
Sbjct 174 TEDEIFRMNAEVAEKIKKIFRTPNSPDPRDFAVPVVPSIGNNDVFPHNLFS-------LG 226
Query 340 SRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWLLINS 398
+ W ++P E R + PG L ++S N + + N L+++
Sbjct 227 PTLQTREYYRLWGDFIPEEQQRMFDRDASFFTEVIPGKLAVLSFNTLYLFKAN--PLVDN 284
Query 399 TDPAGQ-----LQWLVGELQAAEDRGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENT 451
D Q L WL L +RG KV I GH+PP + S + + Y +
Sbjct 285 CDSRKQPGYQLLLWLGYVLDEIRERGMKVWISGHVPPIAKNYDSSCYDKFSLWMHEYRDV 344
Query 452 LAAQFFGHTHVDEF 465
+ +GH ++D F
Sbjct 345 IIGGLYGHMNMDHF 358
>sp|Q6BKG0|PPN1_DEBHA Endopolyphosphatase OS=Debaryomyces hansenii
(strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 /
NBRC 0083 / IGC 2968) OX=284592 GN=PPN1 PE=3 SV=3
Length=713
Score = 313 bits (802), Expect = 4e-96, Method: Composition-based stats.
Identities = 74/310 (24%), Positives = 114/310 (37%), Gaps = 42/310 (14%)
Query 180 LPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPAS 239
L PKP K R L +TD+H D Y G D C G G
Sbjct 74 LGLSPKPKLKIVKGGDEQVLHGRFLHITDMHPDKYYKTGADVGS----LCHSGKGS---- 125
Query 240 RPGAGYWGE-YSKCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHDVW---HQTRQD 293
AG +G+ CD P+ +E L + D V WTGD HD +T +
Sbjct 126 ---AGKYGDAVLGCDSPMVLMEDTLKWVKENLKDKIDFVVWTGDNVRHDNDRRYPRTESN 182
Query 294 QLRALTTVTALVRKFLG------------PVPVYPAVGNHESTPVNSFPPPFIEGNHSSR 341
V+ L+ + +P+ P++GN++ P N F P
Sbjct 183 IFDMNQRVSELMYETFKEENPRGGRPRQLKIPLVPSLGNNDVFPHNLFSP-------GPT 235
Query 342 WLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWL--LINS 398
+ K W ++PA L G ++ P L ++S+N + + N +
Sbjct 236 LQTRELFKIWHDFVPAAQLHIFNRGAYFFKEIIPNELAVLSINTLYLFQSNPLVDNCDRK 295
Query 399 TDPAGQ-LQWLVGELQAAEDRGDKVHIIGHIPPGH--CLKSWSWNYYRIVARYENTLAAQ 455
DP + +WL L+ R KV + GH+PP S Y + Y + +
Sbjct 296 KDPGHKLFEWLGYTLKEMRARNMKVWLSGHVPPNEKNYDISCLRKYIVWMHEYRDVIIGG 355
Query 456 FFGHTHVDEF 465
+GH ++D F
Sbjct 356 LYGHMNIDHF 365
>sp|Q55GC7|SGMD_DICDI Sphingomyelinase phosphodiesterase D OS=Dictyostelium
discoideum OX=44689 GN=sgmD PE=3 SV=1
Length=438
Score = 304 bits (779), Expect = 5e-96, Method: Composition-based stats.
Identities = 101/450 (22%), Positives = 171/450 (38%), Gaps = 60/450 (13%)
Query 197 GAPVSRILFLTDLHWDH---DYLEGTDPDCADPLCCRRGS---------GLPPASRPGAG 244
A ++ L ++D+H+ L C P + + P G
Sbjct 16 NALNNQFLHISDVHYSSAMNSLLYNASVMCIGPTVTKEFDHKEHEDLIEDTERLNLPTNG 75
Query 245 YWGEYSKCDLPLRTLESLLSGLGPAGPF-DMVYWTGDIPAHD----VWHQTRQDQLRALT 299
+G Y CD L ++S + D + +TGD H W +++
Sbjct 76 LYGRYG-CDTNQLLLSEVISEMLNVNSNPDFIIYTGDGAGHGLPNGPWSESQST------ 128
Query 300 TVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSS-RWLYEAMAKAWEPWLPAE 358
+ + P +GN++ P + N S+ ++LYE W W+P
Sbjct 129 -LAKSLYGAYPNTQFIPTIGNNDVFP-----DYNSQCNDSNLQFLYET----WAQWIPTN 178
Query 359 ALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDR 418
+ + G + +SP GL +ISLN S +N DP GQ WL +L AA+
Sbjct 179 QVSSFLYRGSFVVSPVSGLTIISLNTILYSVKNKNTFSTPQDPCGQFAWLEQQLIAAKQA 238
Query 419 GDKVHIIGHIPPG----HCLKSWSWNY----YRIVARYENTLAAQFFGHTHVDEFE-VFY 469
G+ V+IIGHI PG + +W Y + I + Y+ T+ A FFGH H DE + +
Sbjct 239 GNSVYIIGHIFPGLDPFYLQGTWKSQYQTAFFNITSDYQTTITAGFFGHIHRDEIRSIQF 298
Query 470 DEETLSRPLAV-AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANI 528
D +L+ F+ S T NP ++ + Y S + D Y ++ +N+
Sbjct 299 DNPSLTNNHYFPMFIGSSITPVYFNNPTFKQFT----YDSQSKNITDITAYFSDVYISNL 354
Query 529 PGAIPHWQLLYRARETYGLPNTLPTA---WHNLVYRMRGDMQLFQTFWFLYHKGHPPSEP 585
G + +W Y Y + N ++L+ RM +F + + P
Sbjct 355 KGHM-NWTEEYDFVSIYDIDNQYGIGGDQLNSLMERMVSSNSIFNNYDNFRSGSYLSDSP 413
Query 586 CGTPCRLATLCAQLSARADSPALCRHLMPD 615
+ C +A D C ++ +
Sbjct 414 -------SMTCLINAATIDELNACTYIAAN 436
>sp|Q6CWT7|PPN1_KLULA Endopolyphosphatase OS=Kluyveromyces lactis
(strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL
Y-1140 / WM37) OX=284590 GN=PPN1 PE=3 SV=1
Length=681
Score = 310 bits (794), Expect = 2e-95, Method: Composition-based stats.
Identities = 79/310 (25%), Positives = 113/310 (36%), Gaps = 36/310 (12%)
Query 179 SLPTVPKPPPKPPSPPAPGAPV-SRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPP 237
SL P P K + R L +TD+H D Y E T D C R G P
Sbjct 87 SLGLTPNQPVKITDIGGKEKSIKGRFLHITDMHPDLYYKENTSIDDT----CHR--GKPK 140
Query 238 ASRPGAGYWGE-YSKCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHDVW---HQTR 291
A +G CD P + L + + D + WTGD HD +T
Sbjct 141 NDGDRAARFGNAMKGCDGPPDLMYYTLDWIHKNLSDEIDFIIWTGDNVRHDNDRRIPRTE 200
Query 292 QDQLRALTTVTALVRKFLGP----------VPVYPAVGNHESTPVNSFPPPFIEGNHSSR 341
Q V+ L K V + P++GN++ P N F P
Sbjct 201 QQIFDMNRQVSELFLKTFKDHESDDPRDLKVKIIPSLGNNDVFPHNLFSP-------GPT 253
Query 342 WLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWL--LINS 398
+ W ++P T + + PG L +ISLN + + N + N
Sbjct 254 LQTRELYDIWSQFIPPAQQNTFDRYASFFVEAIPGKLAVISLNTLYMFKGNPLVDNCSNK 313
Query 399 TDPA-GQLQWLVGELQAAEDRGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENTLAAQ 455
P L W+ LQ DRG KV + GH+PP + S S + Y + +
Sbjct 314 KQPGYKMLLWVGFTLQELRDRGMKVWLSGHVPPIPKNFDSSCSDKLALWLHEYSDIIIGG 373
Query 456 FFGHTHVDEF 465
F+GH ++D F
Sbjct 374 FYGHMNMDHF 383
>sp|Q04119|PPN1_YEAST Endopolyphosphatase OS=Saccharomyces cerevisiae
(strain ATCC 204508 / S288c) OX=559292 GN=PPN1 PE=1
SV=1
Length=674
Score = 308 bits (790), Expect = 7e-95, Method: Composition-based stats.
Identities = 71/310 (23%), Positives = 115/310 (37%), Gaps = 37/310 (12%)
Query 180 LPTVPKPP--PKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPP 237
L P+ P K R L +TD+H D Y+EG+ D +G P
Sbjct 72 LGLTPREPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVC------HTGKPS 125
Query 238 ASRPGAGYWGE-YSKCDLPLRTLESLLSGLGPA--GPFDMVYWTGDIPAHDVW---HQTR 291
+ A +G+ S CD P+ +E L + D V WTGD HD +T
Sbjct 126 KKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRKHPRTE 185
Query 292 QDQLRALTTVTALVRKFLG----------PVPVYPAVGNHESTPVNSFPPPFIEGNHSSR 341
V + + V V P++GN++ P N F
Sbjct 186 AQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFA-------LGPT 238
Query 342 WLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWL--LINS 398
+ W+ ++P + RT + PG L ++S+N + + N + +
Sbjct 239 LQTREYYRIWKNFVPQQQQRTFDRSASFLTEVIPGKLAVLSINTLYLFKANPLVDNCNSK 298
Query 399 TDPAGQ-LQWLVGELQAAEDRGDKVHIIGHIPP--GHCLKSWSWNYYRIVARYENTLAAQ 455
+P Q L W L+ RG KV + GH+PP + +S + Y + +
Sbjct 299 KEPGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGG 358
Query 456 FFGHTHVDEF 465
+GH ++D F
Sbjct 359 LYGHMNIDHF 368
Score = 39.0 bits (89), Expect = 0.14, Method: Composition-based stats.
Identities = 9/91 (10%), Positives = 28/91 (31%), Gaps = 9/91 (10%)
Query 499 VYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP--------HWQLLYRARET-YGLPN 549
Y++ Y + +L + N +++ Y + E Y + +
Sbjct 579 KYELGPAYVPQLFTPTRFVQFYADLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDS 638
Query 550 TLPTAWHNLVYRMRGDMQLFQTFWFLYHKGH 580
++ +L R+ + ++ +
Sbjct 639 LTVGSYLDLAGRLYENKPAWEKYVEWSFASS 669
>sp|Q5KH67|PPN1_CRYNJ Endopolyphosphatase OS=Cryptococcus neoformans
var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
OX=214684 GN=PPN1 PE=3 SV=1
Length=678
Score = 302 bits (774), Expect = 2e-92, Method: Composition-based stats.
Identities = 81/337 (24%), Positives = 125/337 (37%), Gaps = 52/337 (15%)
Query 179 SLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPA 238
S+P + + R L +TD+H D Y G+ D C R
Sbjct 34 SVPQLDHSELQNVRINKKRPLKGRFLHITDIHPDPHYKTGSTFDSG----CHRKPKKDGK 89
Query 239 SRPG--------------------------AGYWGE-YSKCDLPLRTLESLLSGLGP--A 269
S AG WG S CD P+ + L A
Sbjct 90 SEGKKATENERGNEDLDDKEFDTLIKNEDLAGKWGTAVSDCDCPMSLVNITFDWLKEEWA 149
Query 270 GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLG----PVPVYPAVGNHESTP 325
D V WTGD HD+ + + + +V + L +P+ P++GN++ P
Sbjct 150 NEVDFVVWTGDNARHDIDRRIPRTPKEIFDSNRMIVDRMLDAFGRDMPIVPSIGNNDIYP 209
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNM 384
N + E W+ ++P+EA G ++++ P L +ISLN
Sbjct 210 HNVLAA-------GPSRITEEFLLIWKHFIPSEAAHVFERGAYFSVEVIPDRLAVISLNT 262
Query 385 NFCSRENF---WLLINSTDPAG-QLQWLVGELQAAEDRGDKVHIIGHIPP--GHCLKSWS 438
F N +S DP ++ WL +L RG +V + GH+PP H +
Sbjct 263 LFWYDANTLVDGCRDHSNDPGALEMDWLEVQLNNFRQRGMQVWLTGHVPPHMNHYYDNCY 322
Query 439 WNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLS 475
Y + RY++T+ FGH +VD F F D + L
Sbjct 323 LRYGDLALRYQDTIVGHLFGHMNVDHF-FFIDVDELE 358
>sp|Q756F2|PPN1_EREGS Endopolyphosphatase OS=Eremothecium gossypii
(strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OX=284811 GN=PPN1 PE=3 SV=2
Length=594
Score = 296 bits (758), Expect = 5e-91, Method: Composition-based stats.
Identities = 71/292 (24%), Positives = 111/292 (38%), Gaps = 44/292 (15%)
Query 201 SRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGE-YSKCDLPLRTL 259
R L +TD+H D Y+EG+ C + R AG +G+ CD P+ +
Sbjct 69 GRFLHITDIHPDPLYVEGSSIAG----ACHGDPARDASDR--AGRFGDAMGGCDAPMDLM 122
Query 260 ESLLSGLGPA--GPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLG------- 310
L+ + D V WTGD HD + + + L + +F
Sbjct 123 NYTLAWVATHLRDEIDFVVWTGDNARHDNDRRQPRTAEQILHMNAQVADQFYELFQQQRD 182
Query 311 -----PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRI 365
VPV P++GN++ P N F + + + W ++P E +
Sbjct 183 GDTMQGVPVVPSLGNNDVFPHNMFS-------LGPTLMTRQLQRIWAKFIPEEQRQAFEH 235
Query 366 GGFYALSPYPG-LRLISLNMNFCSRENFWLLINSTDPA----GQLQWLVGELQAAEDRGD 420
+ + P L +IS N + + N L+ N D A L WL L+ R
Sbjct 236 DTSFFVEVIPDRLAVISFNTLYFFKSNP-LVDNCNDKAQPGHALLLWLGSVLEEMRARNM 294
Query 421 KVHIIGHIPP------GHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFE 466
KV + GH+PP G C +W Y Y + + +GH +VD F
Sbjct 295 KVWLSGHVPPIPKNFEGSCYNKLAWWTY----EYRDVIIGGLYGHMNVDHFY 342
>sp|Q9P3S1|PPN1_NEUCR Endopolyphosphatase OS=Neurospora crassa
(strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC
987) OX=367110 GN=epp-1 PE=3 SV=3
Length=731
Score = 295 bits (756), Expect = 2e-89, Method: Composition-based stats.
Identities = 79/325 (24%), Positives = 128/325 (39%), Gaps = 42/325 (13%)
Query 191 PSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYS 250
P + + L +TDLH D Y + D AD C RG G P Y E S
Sbjct 45 PIANSARKLHGKFLHITDLHPDQFYKPHSSTDEAD--ACHRGKG------PAGVYGAEVS 96
Query 251 KCDLPLRTLESLLSGLGP--AGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKF 308
CD P + + + D V WTGD HD ++ + L T + K
Sbjct 97 DCDSPFALINATFDWIAANVKDDIDFVIWTGDTARHDSDEGVPRNADQVLGTNRWIADKM 156
Query 309 LG----------PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAE 358
+P+ P +GN++ P N P + WL + W ++P
Sbjct 157 AELFSDSTGRHLEIPIVPTLGNNDILPHNILLP------GPNSWL-QHYTHIWRRFVPEA 209
Query 359 ALRTLRIGGFYALSPYPG-LRLISLNMNFCSRENFWL--LINSTDPA-GQLQWLVGELQA 414
+ + GG++ + P L + SLN + N + ++P Q++WL +L
Sbjct 210 QRHSFQFGGWFYVEVIPNRLAIFSLNTLYFFDRNAGTDGCASPSEPGYKQMEWLRIQLHI 269
Query 415 AEDRGDKVHIIGHIPPGH------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVF 468
+RG K ++GH+PP ++ Y + +Y + + + FGH ++D F
Sbjct 270 MRERGMKAILMGHVPPARTDSKKLWDENCWQKYSLWLRQYRDVVVSGVFGHMNIDHF-FI 328
Query 469 YDEETLSRPLAVAFLAPSATTYIGL 493
+DE R + V LA A I +
Sbjct 329 HDE----RDINVGQLAGLADNSIDI 349
>sp|Q6CEE7|PPN1_YARLI Endopolyphosphatase OS=Yarrowia lipolytica
(strain CLIB 122 / E 150) OX=284591 GN=PPN1 PE=3 SV=1
Length=747
Score = 277 bits (707), Expect = 5e-82, Method: Composition-based stats.
Identities = 77/411 (19%), Positives = 133/411 (32%), Gaps = 69/411 (17%)
Query 201 SRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR-------------------- 240
+ L +TD+H D + G + + P
Sbjct 49 GKFLHITDIHPDPYFHVGAVAEDKCHVDPDHKDSDYPDEDSELVWFRATGKKKHNHHKGK 108
Query 241 -----PGAGYWGEY-SKCDLPLRTLESLLSGLGPA--GPFDMVYWTGDIPAHDVW---HQ 289
P AGY+G S CD P+ + + + D + WTGD HD +
Sbjct 109 DHEKMPKAGYYGHPLSSCDGPISLMNATFDWIDQNIRDEIDFIIWTGDNVRHDNDNRYPR 168
Query 290 TRQDQLRALTTVTALVRKFLG--------------------PVPVYPAVGNHESTPVNSF 329
QD V++ + +P+ P++GN++ P N +
Sbjct 169 LEQDIFGYNQIVSSKFHELFRYNETRDGEGHNGGGDPQHPLVIPIIPSLGNNDVFPHNLY 228
Query 330 PPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPG-LRLISLNMNFCS 388
+ M + W ++P G +Y G L +ISLN +
Sbjct 229 LA-------GPSFQSRRMLQIWSEFVPEAQQHIFSRGSYYFQEVITGKLAVISLNTLYFY 281
Query 389 RENFWL--LINSTDPA-GQLQWLVGELQAAEDRGDKVHIIGHIPP--GHCLKSWSWNYYR 443
+ N TDP L WL L RG KV + GH+PP + S
Sbjct 282 KSNPMSDGCDEKTDPGYKHLVWLGVVLDEMRQRGMKVWLSGHVPPVEKNYEDSCHLKLAY 341
Query 444 IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQID 503
+ Y + + FGH ++D F V D + + + + P Y + I
Sbjct 342 WLTEYRDIIVGSVFGHMNIDHFVVM-DPKKIEKAQSQDLGTPGL-GYKSHVTDFLDVAIS 399
Query 504 GNYSGSSHVVLDHETYILNLTQANIPGAIP-HWQLLYRARETYGLPNTLPT 553
++ + + YI ++ + P W Y + + + + P+
Sbjct 400 ASHPVHTFGSIYKRNYIESVREDYSEIPGPKKWLDEYASN--FAIAHVSPS 448
>sp|P07602|SAP_HUMAN Prosaposin OS=Homo sapiens OX=9606 GN=PSAP
PE=1 SV=2
Length=524
Score = 53.2 bits (126), Expect = 6e-06, Method: Composition-based stats.
Identities = 21/82 (26%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLL-KIAPPAVCQSIVHLF 140
+ +L C ICK + TA LK + K C+ L K A C+ IV +
Sbjct 54 NKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSY 113
Query 141 EDDMVEVWRRSVLSPSEACGLL 162
++++ + + P E C L
Sbjct 114 LPVILDIIKGEMSRPGEVCSAL 135
Score = 44.0 bits (102), Expect = 0.004, Method: Composition-based stats.
Identities = 15/84 (18%), Positives = 33/84 (39%), Gaps = 1/84 (1%)
Query 79 RLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVH 138
+ +V ++ C +C+ L + + + K+C+ L + CQ +V
Sbjct 303 KKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVD 362
Query 139 LFEDDMVEVWRRSVLSPSEACGLL 162
+ ++ + V SP C +L
Sbjct 363 TYGSSILSILLEEV-SPELVCSML 385
Score = 40.5 bits (93), Expect = 0.052, Method: Composition-based stats.
Identities = 19/79 (24%), Positives = 31/79 (39%), Gaps = 3/79 (4%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C +CK L ++ L+K + + K C+ L C V +E ++E+
Sbjct 409 CEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVE 468
Query 151 SVLSPSEACGLLLGSTCGH 169
V+ PS C L C
Sbjct 469 -VMDPSFVC--LKIGACPS 484
>sp|P10960|SAP_RAT Prosaposin OS=Rattus norvegicus OX=10116 GN=Psap
PE=1 SV=1
Length=554
Score = 51.7 bits (122), Expect = 2e-05, Method: Composition-based stats.
Identities = 27/129 (21%), Positives = 50/129 (39%), Gaps = 5/129 (4%)
Query 78 PRLRDVFGWGN-LTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSI 136
P +DV N + C +C+ + ++ + + K C+LL CQ +
Sbjct 300 PYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEV 359
Query 137 VHLFEDDMVEVWRRSVLSPSEACGLL-LGSTCGHWD--IFSSWNISLPTVPKPPPKPPSP 193
+ F +++V V +P+ CG++ L S + + + +PK P P P
Sbjct 360 LVTFGPSLLDVLMHEV-NPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQP 418
Query 194 PAPGAPVSR 202
P R
Sbjct 419 EEPKQSALR 427
Score = 49.4 bits (116), Expect = 9e-05, Method: Composition-based stats.
Identities = 17/82 (21%), Positives = 32/82 (39%), Gaps = 1/82 (1%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAP-PAVCQSIVHLF 140
+L C ICK + T LK + K C + + A C+ +V +
Sbjct 54 SKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSY 113
Query 141 EDDMVEVWRRSVLSPSEACGLL 162
++++ + + +P E C L
Sbjct 114 LPVILDMIKGEMSNPGEVCSAL 135
Score = 44.4 bits (103), Expect = 0.003, Method: Composition-based stats.
Identities = 27/116 (23%), Positives = 44/116 (38%), Gaps = 12/116 (10%)
Query 44 ALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINL 103
A+ AL AP + Q + L VP ++ G+ C +CK L +
Sbjct 403 AIVSALPKEP---APPKQPEEPKQ---SALRAHVPPQKNG-GF----CEVCKKLVIYLEH 451
Query 104 GLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEAC 159
L+K + + K C+ L C V +E ++E+ V+ PS C
Sbjct 452 NLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVE-VMDPSFVC 506
>sp|Q61207|SAP_MOUSE Prosaposin OS=Mus musculus OX=10090 GN=Psap
PE=1 SV=2
Length=557
Score = 50.9 bits (120), Expect = 3e-05, Method: Composition-based stats.
Identities = 23/115 (20%), Positives = 40/115 (35%), Gaps = 10/115 (9%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C C+ + + + + C LL CQ +V F +++++
Sbjct 317 CQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIH 376
Query 151 SVLSPSEACGLL-LGSTCG--------HWDIFSSWNISLPTVPKPPPKPPSPPAP 196
V +PS CG++ L + S + PT PK P +P P
Sbjct 377 EV-NPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALP 430
Score = 49.0 bits (115), Expect = 1e-04, Method: Composition-based stats.
Identities = 17/82 (21%), Positives = 32/82 (39%), Gaps = 1/82 (1%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAP-PAVCQSIVHLF 140
+L C ICK + T LK + K C + + A C+ +V +
Sbjct 54 SKPTAKSLPCDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSY 113
Query 141 EDDMVEVWRRSVLSPSEACGLL 162
++++ + + +P E C L
Sbjct 114 LPVILDMIKGEMSNPGEVCSAL 135
Score = 41.7 bits (96), Expect = 0.019, Method: Composition-based stats.
Identities = 24/108 (22%), Positives = 40/108 (37%), Gaps = 7/108 (6%)
Query 52 SRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNV 111
S +L P Q + L VP ++ G+ C +CK L + L+K
Sbjct 409 SALLKEPTPPKQ-PAQPKQSALPAHVPPQKNG-GF----CEVCKKLVLYLEHNLEKNSTK 462
Query 112 ARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEAC 159
+ + K C+ L C V +E ++E+ V+ P C
Sbjct 463 EEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVE-VMDPGFVC 509
>sp|Q9SB68|ADPRM_ARATH Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Arabidopsis thaliana OX=3702 GN=At4g24730
PE=2 SV=1
Length=311
Score = 50.1 bits (118), Expect = 3e-05, Method: Composition-based stats.
Identities = 49/229 (21%), Positives = 76/229 (33%), Gaps = 56/229 (24%)
Query 267 GPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLG-PVPVYPAVGNHESTP 325
G V GDI V +DQ A T LV +F PVY +GNH
Sbjct 51 NQHGNLKFVINMGDI----VDGFCPKDQSLAATK--KLVHEFEKFNGPVYHMIGNHCLYN 104
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSP---------YPG 376
+ + A+ + P R + + G+ +
Sbjct 105 LPREELLPLLKIPGRD------GNAYYDFSPTPEYRVVVLDGYDISAVGWPQEHPNTIAA 158
Query 377 LRLISLNMNFCSRENFWLLINSTDPAG------------------QLQWLVGELQAAEDR 418
L+++ +N + PAG QLQWL LQ A +
Sbjct 159 LKIL-------EEKNPNT--DKNSPAGLEDVARRFVKYNGGVGEKQLQWLDSVLQDASNS 209
Query 419 GDKVHIIGHIP--PGHCLKS---WSW-NYYRIVARYENTLAAQFFGHTH 461
+V + GH+P PG K+ W++ I+ +Y++ GH H
Sbjct 210 NQRVIVCGHVPMSPGVASKAALLWNFDEVMNIIHKYDSVKVC-LSGHDH 257
>sp|P20097|SAP_CAVPO Saposin-C OS=Cavia porcellus OX=10141 GN=PSAP
PE=1 SV=1
Length=81
Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats.
Identities = 15/73 (21%), Positives = 31/73 (42%), Gaps = 1/73 (1%)
Query 87 GNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVE 146
++TC C+ + + + ++ +C LL + VCQ +V + D +V
Sbjct 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query 147 VWRRSVLSPSEAC 159
+ + +SP C
Sbjct 61 LLLQE-MSPELVC 72
>sp|P38887|YH02_YEAST Uncharacterized protein YHR202W OS=Saccharomyces
cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YHR202W
PE=1 SV=1
Length=602
Score = 50.5 bits (119), Expect = 4e-05, Method: Composition-based stats.
Identities = 70/422 (17%), Positives = 140/422 (33%), Gaps = 50/422 (12%)
Query 180 LPTVPKPPPKPPSPPAPGAPVSRILFLTDLHW-DHDYLEGTDPDCADPLCCRRGSGLPPA 238
+ P + P+ P L D+H D +++ TD G +
Sbjct 16 IFAKPYQQQQAVLAPSQDVP------LRDIHIGDINFIHTTDT--------HGWLGSHLS 61
Query 239 SRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRAL 298
WG++ + ++ L + +V TGD D + L
Sbjct 62 QNDYDADWGDF------VAFVDILREKILRQSRDVIVIDTGD--KRDGNGLSDATWPPGL 113
Query 299 TTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAE 358
+ + + + +GNHE S G S + + ++ +
Sbjct 114 RS-SEIFNMMDYDL---LTLGNHELYTAES-AILEYRGTSQSSKFKDKYVCSNVEFIEDD 168
Query 359 ALRTLRIGGFY--ALSPYPGLRLISLNMNFCSRE--NFWLLINSTDPAGQLQWLVGELQA 414
R + G Y +P R+++L+ F + N ++ + Q W ++
Sbjct 169 GTR-VPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTPPLEEITQKSWFQNMVET 227
Query 415 AEDRG-DKVHIIGHIPPGHCLKSWSWNYYRIVARYE-NTLAAQFFGHTHVDEFEVFYDEE 472
+ D + + GH+P + + ++ +Y NT+ F GHTH+ +F V D +
Sbjct 228 NREEEIDLIIVFGHLPATDPTEREMHKIHALIRKYYPNTVIQYFGGHTHIRDF-VQLDSK 286
Query 473 TLSRPLA-----VAFLAPSAT-TYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQA 526
+ V FL+ + T +P + ID N + + + N+ +
Sbjct 287 STCLQSGRFAETVGFLSINMTDPVDAESPIFSRRYIDFNKEAFKYHLSKL-GHDSNVPVS 345
Query 527 NIPGAIPHWQLLYRARETYGLP---NTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPS 583
G +L+ R L +P ++ + + L + + HK P
Sbjct 346 TKKGKTIS-RLVNDLRHELNLNEKLGYIPQTYYVSTRPLNSEENL---YHLITHKILPNL 401
Query 584 EP 585
P
Sbjct 402 IP 403
>sp|Q8C1C1|SAPL1_MOUSE Proactivator polypeptide-like 1 OS=Mus
musculus OX=10090 GN=Psapl1 PE=1 SV=2
Length=522
Score = 50.1 bits (118), Expect = 4e-05, Method: Composition-based stats.
Identities = 23/125 (18%), Positives = 52/125 (42%), Gaps = 4/125 (3%)
Query 89 LTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVW 148
LTC +C L ++ L A + ++C ++ C ++V + ++V++
Sbjct 293 LTCDVCLNLVQELDKWLVTNSTEALISHTLERVCTVVPEPLVQQCITLVDTYSPELVQLM 352
Query 149 RRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTD 208
+ ++P + C + CG S + ++ T P P + + R+L ++
Sbjct 353 SK--VTPEKVCETI--KLCGSKRRARSISRAVATTPSLPVDEENQGSFCQGCKRLLGMSS 408
Query 209 LHWDH 213
+ DH
Sbjct 409 QNLDH 413
>sp|Q28FE0|CPPED_XENTR Serine/threonine-protein phosphatase CPPED1
OS=Xenopus tropicalis OX=8364 GN=cpped1 PE=2 SV=1
Length=311
Score = 49.4 bits (116), Expect = 5e-05, Method: Composition-based stats.
Identities = 40/234 (17%), Positives = 72/234 (31%), Gaps = 51/234 (22%)
Query 248 EYSKCD-------LPLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALT 299
E CD +R E + + P GD+ + +++Q + L
Sbjct 48 EIGDCDYGGDEWEQEIRLTEEAVKAINKLSPKPKFFVLCGDLVHSMPGIEWKEEQEKDLK 107
Query 300 TVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEA 359
V ++K +P+ GNH+ GN + +A +W +
Sbjct 108 NV---LQKTHQEIPLVFVSGNHDI------------GNAPTPETIQAYCDSWG-----DD 147
Query 360 LRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRG 419
+ +GG + + LN + + +WL +L AE+R
Sbjct 148 YFSFWVGGVFF---------LVLNSQLFFDASKCPEL----KDNHDRWLAAQLAIAEERK 194
Query 420 DK-VHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFF---------GHTHVD 463
K + HIP +Y+ I + F GH H +
Sbjct 195 CKHAIVFQHIPLFLQKADEDNDYFNIEKSLRQEILQMFLKAGIKAVFSGHYHRN 248
>sp|P26779|SAP_BOVIN Prosaposin OS=Bos taurus OX=9913 GN=PSAP
PE=1 SV=3
Length=525
Score = 48.6 bits (114), Expect = 1e-04, Method: Composition-based stats.
Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 9/107 (8%)
Query 62 HPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKL 121
H S +G PA R++PR F C +CK L ++ L+K ++ + K
Sbjct 387 HLCSSRGLPAATVRVMPRKDGGF------CEVCKKLVGYLDRNLEKNSTKEQILAALEKG 440
Query 122 CNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCG 168
C+ L C V +E ++E+ V+ PS C L C
Sbjct 441 CSFLPDQYRKQCDQFVTEYEPVLIEILVE-VMDPSFVC--LKIGACP 484
Score = 48.2 bits (113), Expect = 2e-04, Method: Composition-based stats.
Identities = 20/82 (24%), Positives = 33/82 (40%), Gaps = 1/82 (1%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLL-KIAPPAVCQSIVHLF 140
+L C ICK + TA LK + + C+ L K A C+ IV +
Sbjct 54 SKPTVKSLPCDICKDVITAAGNLLKDNATEQEILMYLERTCDWLPKPNMSASCKEIVDSY 113
Query 141 EDDMVEVWRRSVLSPSEACGLL 162
++++ + + P E C L
Sbjct 114 LPVILDMIKGQMSHPGEVCSAL 135
Score = 42.8 bits (99), Expect = 0.008, Method: Composition-based stats.
Identities = 15/87 (17%), Positives = 33/87 (38%), Gaps = 2/87 (2%)
Query 83 VFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFED 142
++ C +C+ + + + + K+C+ L + CQ +V +
Sbjct 308 APAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGS 367
Query 143 DMVEVWRRSVLSPSEACGLL-LGSTCG 168
++ + SP C +L L S+ G
Sbjct 368 SILSILLDEA-SPELVCSMLHLCSSRG 393
>sp|O13035|SAP_CHICK Prosaposin OS=Gallus gallus OX=9031 GN=PSAP
PE=1 SV=1
Length=518
Score = 47.4 bits (111), Expect = 3e-04, Method: Composition-based stats.
Identities = 18/82 (22%), Positives = 30/82 (37%), Gaps = 1/82 (1%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAV-CQSIVHLF 140
++ C +CK L T + LK + S K C L A C+ IV +
Sbjct 55 SKPAVNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKRCEFLPDQGLASECKEIVDSY 114
Query 141 EDDMVEVWRRSVLSPSEACGLL 162
++++ + P C L
Sbjct 115 LPVIMDMIKEEFDKPEVVCSAL 136
Score = 44.7 bits (104), Expect = 0.002, Method: Composition-based stats.
Identities = 17/129 (13%), Positives = 41/129 (32%), Gaps = 19/129 (15%)
Query 69 HPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIA 128
H ++ + + C IC+ + + L+ + +C LL +
Sbjct 291 HEVKMETVEKATVQEKTFS--VCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPAS 348
Query 129 PPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPP 188
C+ + ++ ++++ + +P C ++ C KPP
Sbjct 349 VKDQCKDFIEVYGQALIDMLLEAT-NPEAVC--VMLKCC--------------AANKPPQ 391
Query 189 KPPSPPAPG 197
+P G
Sbjct 392 QPVVVKPAG 400
Score = 44.0 bits (102), Expect = 0.004, Method: Composition-based stats.
Identities = 18/78 (23%), Positives = 34/78 (44%), Gaps = 3/78 (4%)
Query 91 CPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRR 150
C ICK + + L+K + ++ K+C+ L + C V +E +V++
Sbjct 403 CDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAE 462
Query 151 SVLSPSEACGLLLGSTCG 168
++ P+ C L CG
Sbjct 463 -MMDPTFVCTKL--GVCG 477
>sp|Q5U3W0|CPPED_DANRE Serine/threonine-protein phosphatase CPPED1
OS=Danio rerio OX=7955 GN=cpped1 PE=2 SV=1
Length=309
Score = 45.9 bits (107), Expect = 7e-04, Method: Composition-based stats.
Identities = 42/250 (17%), Positives = 73/250 (29%), Gaps = 54/250 (22%)
Query 232 GSGLPPASRPGAGYWGEYSKCDL-------PLRTLESLLSGLGPAGPFD-MVYWTGDIPA 283
+ P A G+ CD ++ + + + P + GD+
Sbjct 35 QAADPQLGLMKAWRIGD---CDSGGDEWDEEVQLTKQAVQAINKLQPKPRFIVLCGDLVH 91
Query 284 HDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWL 343
R+ Q++ L +R +P+ GNH+ GN +
Sbjct 92 AMPGSPFREQQIKDLK---DALRGTDPHIPLVFVSGNHD------------LGNAPTPDT 136
Query 344 YEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAG 403
E W G Y G+ + LN F + +
Sbjct 137 VEQFCHEW--------------GDDYFSFWVGGVLCLVLNSQFFFDSSGCPELME----A 178
Query 404 QLQWLVGELQAAEDRGDK-VHIIGHIP-----PGHCLKSWSWN---YYRIVARYENT-LA 453
WL LQ A + V + HIP P ++ ++ R++ +
Sbjct 179 HEVWLENRLQMAVQTPSRHVLVFQHIPLFLRTPDEEDDYFNLQRGIREHLIQRFKRAGVK 238
Query 454 AQFFGHTHVD 463
A F GH H +
Sbjct 239 AVFSGHYHRN 248
>sp|Q5RCR9|CPPED_PONAB Serine/threonine-protein phosphatase CPPED1
OS=Pongo abelii OX=9601 GN=CPPED1 PE=2 SV=1
Length=314
Score = 45.9 bits (107), Expect = 7e-04, Method: Composition-based stats.
Identities = 43/233 (18%), Positives = 66/233 (28%), Gaps = 52/233 (22%)
Query 250 SKCDL-------PLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTTV 301
CD +R E + + P GD+ R +Q L V
Sbjct 52 GDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRV 111
Query 302 TALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALR 361
V + +P+ GNH+ GN + + + W
Sbjct 112 LRTVDR---AIPLVLVSGNHDI------------GNAPTAETVDEFCRTW---------- 146
Query 362 TLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDK 421
G Y G+ + LN F + + Q QWL +L A R +
Sbjct 147 ----GDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQ----AQDQWLDEQLSIARQRHCQ 198
Query 422 -VHIIGHIPPG-HCLKSWSWNYYRIVARYENTLAAQFF---------GHTHVD 463
I HIP + Y+ + LA +F GH H +
Sbjct 199 HAIIFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRN 251
>sp|Q3LIE5|ADPRM_HUMAN Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Homo sapiens OX=9606 GN=ADPRM PE=1 SV=1
Length=342
Score = 45.5 bits (106), Expect = 0.001, Method: Composition-based stats.
Identities = 50/250 (20%), Positives = 87/250 (35%), Gaps = 58/250 (23%)
Query 264 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
+ V GDI D ++ ++L V + ++ VPV+ GNHE
Sbjct 58 DWNNESSMPCCVLQLGDII--DGYNAQYNASKKSLELVMDMFKRL--KVPVHHTWGNHEF 113
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 383
N ++++L + + E + + ++ + P+P R I L+
Sbjct 114 Y--NFSREYLTHSKLNTKFLEDQIVHH------PETMPSEDYYAYHFV-PFPKFRFILLD 164
Query 384 -------------------MNFCSRENFWLLINS----TDPA----------GQLQWLVG 410
M N +NS ++P QL WL
Sbjct 165 AYDLSVLGVDQSSPKYEQCMKILREHNPNTELNSPQGLSEPQFVQFNGGFSQEQLNWLNE 224
Query 411 ELQAAEDRGDKVHIIGHIP--PGHCLKSW-SWNYYR---IVARYENTLAAQFFGHTH--- 461
L ++ +KV I+ H+P P +WNY ++ +E + F GHTH
Sbjct 225 VLTFSDTNQEKVVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCF-FAGHTHDGG 283
Query 462 --VDEFEVFY 469
D F V++
Sbjct 284 YSEDPFGVYH 293
>sp|Q8BFS6|CPPED_MOUSE Serine/threonine-protein phosphatase CPPED1
OS=Mus musculus OX=10090 GN=Cpped1 PE=1 SV=1
Length=312
Score = 44.7 bits (104), Expect = 0.001, Method: Composition-based stats.
Identities = 44/232 (19%), Positives = 68/232 (29%), Gaps = 51/232 (22%)
Query 250 SKCDL-------PLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTTV 301
CD +R E + + P GD+ RQ+Q R L V
Sbjct 52 GNCDAGGDEWGQEIRLTEQAVEAINKLNPKPKFFVLCGDLVHAMPGTPWRQEQTRDLQRV 111
Query 302 TALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALR 361
V + +P+ GNH+ GN + E + W
Sbjct 112 LKAVDQ---DIPLVMVSGNHD------------LGNAPTAETVEEFCQTW---------- 146
Query 362 TLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDK 421
G Y G+ + LN F + + Q WL +L AE + +
Sbjct 147 ----GDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQ----AQDHWLDQQLNIAEQKQCQ 198
Query 422 -VHIIGHIP---PGHCLKSWSWNYYRIVAR------YENTLAAQFFGHTHVD 463
+ HIP +N + V + + A F GH H +
Sbjct 199 HAIVFQHIPLFLQSIDEDDDYFNLTKTVRKELAEKLTRAGIRAVFSGHYHRN 250
>sp|Q9BRF8|CPPED_HUMAN Serine/threonine-protein phosphatase CPPED1
OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3
Length=314
Score = 44.0 bits (102), Expect = 0.003, Method: Composition-based stats.
Identities = 43/233 (18%), Positives = 66/233 (28%), Gaps = 52/233 (22%)
Query 250 SKCDL-------PLRTLESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTTV 301
CD +R E + + P GD+ R +Q L V
Sbjct 52 GDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRV 111
Query 302 TALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALR 361
V + +P+ GNH+ GN + E + W
Sbjct 112 LRAVDR---AIPLVLVSGNHDI------------GNTPTAETVEEFCRTW---------- 146
Query 362 TLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDK 421
G Y G+ + LN F + + Q QWL +L A R +
Sbjct 147 ----GDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQ----AQDQWLDEQLSIARQRHCQ 198
Query 422 -VHIIGHIPPG-HCLKSWSWNYYRIVARYENTLAAQFF---------GHTHVD 463
+ HIP + Y+ + LA +F GH H +
Sbjct 199 HAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRN 251
>sp|A7YY53|ADPRM_BOVIN Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Bos taurus OX=9913 GN=ADPRM PE=2 SV=2
Length=337
Score = 42.4 bits (98), Expect = 0.009, Method: Composition-based stats.
Identities = 46/222 (21%), Positives = 78/222 (35%), Gaps = 53/222 (24%)
Query 279 GDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNH 338
GDI D ++ + ++L V + VPV+ GNHE N
Sbjct 73 GDII--DGYNAQYKASEKSLERVMNTFQML--RVPVHHTWGNHEFY--NFSRDYLTNSKL 126
Query 339 SSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISL---------------- 382
++++L + +A E + + ++ + P+P R I L
Sbjct 127 NTKFLEDQIAHH------PETVPSEDYYAYHFV-PFPKFRFILLDAYDMSVLGVDQSSPK 179
Query 383 -------------NMNFCS----RENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
N S RE ++ N QL WL L ++ +KV I+
Sbjct 180 YQQCLKILREHNPNTELNSPQGLREPQFVQFNGGFSPEQLNWLNAVLTFSDRNQEKVVIV 239
Query 426 GHIP--PGHCLKSW-SWNYYR---IVARYENTLAAQFFGHTH 461
H+P P +WNY ++ ++ + F GHTH
Sbjct 240 SHLPIYPEASDSVCLAWNYRDALAVIWSHKCVVCF-FAGHTH 280
>sp|Q99KS6|ADPRM_MOUSE Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Mus musculus OX=10090 GN=Adprm PE=1 SV=1
Length=340
Score = 42.4 bits (98), Expect = 0.009, Method: Composition-based stats.
Identities = 48/237 (20%), Positives = 82/237 (35%), Gaps = 53/237 (22%)
Query 264 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
+ V GDI D ++ + ++L V + VPV+ GNHE
Sbjct 58 DWNKESSMPCCVLQLGDII--DGYNAQYKVSEKSLELVMNTFQML--KVPVHHTWGNHEF 113
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 383
N +S++L + +A+ E + ++ + P+P R I L+
Sbjct 114 Y--NFSRDYLASSKLNSKFLEDQIAQH------PETTPSENYYAYHFV-PFPKFRFILLD 164
Query 384 -------------------MNFCSRENFWLLINS----TDPA----------GQLQWLVG 410
M N + +NS ++P QL WL
Sbjct 165 SYDLSVLGIDPSSPKYEQCMKMLREHNPNVELNSPQGLSEPQYVQFNGGFSQEQLNWLNE 224
Query 411 ELQAAEDRGDKVHIIGHIP--PGHCLKSW-SWNYYR---IVARYENTLAAQFFGHTH 461
L ++ +KV I+ H+P P +WNY I+ ++ + GHTH
Sbjct 225 VLTFSDTNQEKVVIVSHLPIYPEASDSVCLAWNYVDALSIIWSHKCVVCF-LAGHTH 280
>sp|Q76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with
thrombospondin motifs 13 OS=Homo sapiens OX=9606 GN=ADAMTS13
PE=1 SV=1
Length=1427
Score = 42.8 bits (99), Expect = 0.012, Method: Composition-based stats.
Identities = 22/105 (21%), Positives = 32/105 (30%), Gaps = 7/105 (7%)
Query 4 YGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHP 63
+ + C SG DG A GL W L+L L+ +R +W P P
Sbjct 234 HDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSL---LSAGRARCVWDPPRPQP 290
Query 64 ----LSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLG 104
P P + + R FG + C +
Sbjct 291 GSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQAL 335
>sp|Q6NUJ1|SAPL1_HUMAN Proactivator polypeptide-like 1 OS=Homo
sapiens OX=9606 GN=PSAPL1 PE=2 SV=2
Length=521
Score = 41.7 bits (96), Expect = 0.019, Method: Composition-based stats.
Identities = 16/83 (19%), Positives = 35/83 (42%), Gaps = 2/83 (2%)
Query 82 DVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLL-KIAPPAVCQSIVHLF 140
+ +L C +C+ + A GL + + + ++ +K C L A C+ +V
Sbjct 55 NKPTAKSLPCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPSQESSAGCKWMVDAH 114
Query 141 EDDMVEVWR-RSVLSPSEACGLL 162
++ + R +P++ C L
Sbjct 115 SSAILSMLRGAPDSAPAQVCTAL 137
Score = 39.0 bits (89), Expect = 0.13, Method: Composition-based stats.
Identities = 25/153 (16%), Positives = 60/153 (39%), Gaps = 17/153 (11%)
Query 68 GHPARLHRIV------------PRLRDVFGWGN-LTCPICKGLFTAINLGLKKEPNVARV 114
G PARL ++V PR + +TC +C + ++ L + +
Sbjct 258 GAPARLTQVVAMDGVPSLELGLPRKQSEMQMKAGVTCEVCMNVVQKLDHWLMSNSSELMI 317
Query 115 GSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFS 174
++C+++ + C +V + +V++ + ++P + C + CG+
Sbjct 318 THALERVCSVMPASITKECIILVDTYSPSLVQLVAK--ITPEKVCKFI--RLCGNRRRAR 373
Query 175 SWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
+ + + VP P + + R+L ++
Sbjct 374 AVHDAYAIVPSPEWDAENQGSFCNGCKRLLTVS 406
>sp|Q7T0Q0|ADPRM_XENLA Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Xenopus laevis OX=8355 GN=adprm PE=2 SV=1
Length=356
Score = 40.9 bits (94), Expect = 0.026, Method: Composition-based stats.
Identities = 20/85 (24%), Positives = 36/85 (42%), Gaps = 5/85 (6%)
Query 382 LNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSW-S 438
LN E ++L N QL W+ L +++ + +KV ++ H+P P
Sbjct 208 LNSPTGLEEEQFVLFNGGISPSQLDWIQSILTSSDKKEEKVFVVSHLPVHPDAADTMCLI 267
Query 439 WNYYRIVA--RYENTLAAQFFGHTH 461
WNY +++ + + GH H
Sbjct 268 WNYPEVLSMLQSHPCVVGYLAGHNH 292
>sp|Q5M886|ADPRM_RAT Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Rattus norvegicus OX=10116 GN=Adprm PE=1
SV=1
Length=337
Score = 40.9 bits (94), Expect = 0.031, Method: Composition-based stats.
Identities = 47/237 (20%), Positives = 81/237 (34%), Gaps = 53/237 (22%)
Query 264 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
+ V GDI D ++ + ++L V + VPV+ GNHE
Sbjct 58 DWNKESSMPCCVLQLGDII--DGYNAQYKVSEKSLELVMNTFQML--KVPVHHTWGNHEF 113
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 383
N +S++L + + + E + ++ + P+P R I L+
Sbjct 114 Y--NFSRDYLANSKLNSKFLEDQIPQH------PETTPSENYYAYHFV-PFPKFRFILLD 164
Query 384 -------------------MNFCSRENFWLLINS----TDPA----------GQLQWLVG 410
M N + +NS ++P QL WL
Sbjct 165 SYDLSVLGIDQFSPKYEQCMKILREHNPNVELNSPQGLSEPQYVQFNGGFSQEQLNWLNE 224
Query 411 ELQAAEDRGDKVHIIGHIP--PGHCLKSW-SWNYYR---IVARYENTLAAQFFGHTH 461
L ++ +KV I+ H+P P +WNY I+ ++ + GHTH
Sbjct 225 VLTFSDANQEKVVIVSHLPIYPEASDSVCLAWNYVDALSIIWSHQCVVCF-LAGHTH 280
>sp|Q66JJ3|ADPRM_XENTR Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Xenopus tropicalis OX=8364 GN=adprm PE=2
SV=1
Length=342
Score = 40.5 bits (93), Expect = 0.040, Method: Composition-based stats.
Identities = 18/100 (18%), Positives = 37/100 (37%), Gaps = 17/100 (17%)
Query 401 PAGQLQWLVGELQAAEDRGDKVHIIGHIP--PGHCLKSW-SWNYYRIVA--RYENTLAAQ 455
QL W+ L +++++ + V ++ H+P P WNY +++ + +
Sbjct 213 SPSQLDWMERVLTSSDEKEENVFVVSHLPVHPDAADPMCLVWNYPEVLSVLQSHPCVVGY 272
Query 456 FFGHTH-----VD-------EFEVFYDEETLSRPLAVAFL 483
GH H +D F + SR ++
Sbjct 273 LAGHNHEGRYCMDPYGIHHLTFSGVIETPPESRAFGTMYV 312
>sp|Q58DC0|CPPED_BOVIN Serine/threonine-protein phosphatase CPPED1
OS=Bos taurus OX=9913 GN=CPPED1 PE=2 SV=1
Length=313
Score = 40.1 bits (92), Expect = 0.041, Method: Composition-based stats.
Identities = 43/257 (17%), Positives = 69/257 (27%), Gaps = 56/257 (22%)
Query 230 RRGSGLPPASRPGAGYWGEY-----SKCDL-------PLRTLESLLSGLGPAGPF-DMVY 276
R G + +G CD +R E + + P
Sbjct 27 REWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFV 86
Query 277 WTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEG 336
GD+ R++Q L V V +P+ GNH+ G
Sbjct 87 LCGDLVHAMPGRPWRKEQTEDLQRVLRTVDS---DIPLVLVSGNHDV------------G 131
Query 337 NHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLI 396
N + + W G Y G+ + LN F + +
Sbjct 132 NVPTPETIAEFQRTW--------------GDDYFSFWVGGVLFLVLNSQFLYDASRCPAL 177
Query 397 NSTDPAGQLQWLVGELQAAEDRGDK-VHIIGHIPPGHCLKSWSWNYYRIVARYENTLA-- 453
WL +L+ A R + + HIP +Y+ + +A
Sbjct 178 KQ----EHDHWLDQQLRIAGQRACRHAVVFQHIPLFLQSIGEDDDYFNLTKSVRKEMADK 233
Query 454 -------AQFFGHTHVD 463
A F GH H +
Sbjct 234 FVEAGVKAVFSGHYHRN 250
>sp|Q8H5F8|ADPRM_ORYSJ Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Oryza sativa subsp. japonica OX=39947 GN=Os07g0688000
PE=2 SV=1
Length=321
Score = 40.1 bits (92), Expect = 0.047, Method: Composition-based stats.
Identities = 24/66 (36%), Positives = 30/66 (45%), Gaps = 7/66 (11%)
Query 402 AGQLQWLVGELQAAEDRGDKVHIIGHIP--PGH-CLKSWSWNYYR---IVARYENTLAAQ 455
QL WL LQ A R V + H+P PG + WNY IV +Y+ + A
Sbjct 201 KEQLSWLNDVLQDASARRQNVILCSHLPMDPGSASFAALMWNYDEVMAIVRQYK-CVKAC 259
Query 456 FFGHTH 461
F GH H
Sbjct 260 FAGHDH 265
>sp|Q29075|NKL_PIG Antimicrobial peptide NK-lysin (Fragment) OS=Sus
scrofa OX=9823 GN=NKL PE=1 SV=1
Length=129
Score = 37.8 bits (86), Expect = 0.072, Method: Composition-based stats.
Identities = 25/104 (24%), Positives = 41/104 (39%), Gaps = 12/104 (12%)
Query 42 ALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPR-----LRDVFGWGNLTCPICKG 96
LA + + L A AHP + L P+ R+ G L C C+
Sbjct 2 GLAFSGLTPEHSAL---ARAHPCDGEQFCQNLAPEDPQGDQLLQREELG---LICESCRK 55
Query 97 LFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLF 140
+ + + +PN V A ++C+ +KI VC+ I+ F
Sbjct 56 IIQKLEDMVGPQPNEDTVTQAASRVCDKMKILR-GVCKKIMRTF 98
>sp|P9WL81|Y2577_MYCTU Uncharacterized protein Rv2577 OS=Mycobacterium
tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=Rv2577
PE=3 SV=1
Length=529
Score = 39.7 bits (91), Expect = 0.092, Method: Composition-based stats.
Identities = 43/238 (18%), Positives = 71/238 (30%), Gaps = 40/238 (17%)
Query 205 FLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYS------KCD----- 253
LT+L D DY+ D P + +G+ S D
Sbjct 130 HLTNLTPDTDYVYAAVHDGTTPELGTARTAPSGRKPLRFTSFGDQSTPALGRLADGRYVS 189
Query 254 ----LPLR-TLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKF 308
P + + + P GD+ ++ + T R
Sbjct 190 DNIGSPFAGDITIAIERIAPL----FNLINGDLCYANLAQDRIRTWSDWFDNNTRSARYR 245
Query 309 LGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGF 368
P PA GNHE N I Y+A + +P G +
Sbjct 246 ----PWMPAAGNHE----NEVGNGPIG--------YDAYQTYFA--VPDSGSSPQLRGLW 287
Query 369 YALSPYPGLRLISL-NMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
Y+ + +R+ISL N + C ++ + Q +WL EL A + ++
Sbjct 288 YSFTA-GSVRVISLHNDDVCYQDGGNSYVRGYSGGEQRRWLQAELANARRDSEIDWVV 344
>sp|P9WL80|Y2577_MYCTO Uncharacterized protein MT2654 OS=Mycobacterium
tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=MT2654
PE=3 SV=1
Length=529
Score = 39.7 bits (91), Expect = 0.092, Method: Composition-based stats.
Identities = 43/238 (18%), Positives = 71/238 (30%), Gaps = 40/238 (17%)
Query 205 FLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYS------KCD----- 253
LT+L D DY+ D P + +G+ S D
Sbjct 130 HLTNLTPDTDYVYAAVHDGTTPELGTARTAPSGRKPLRFTSFGDQSTPALGRLADGRYVS 189
Query 254 ----LPLR-TLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKF 308
P + + + P GD+ ++ + T R
Sbjct 190 DNIGSPFAGDITIAIERIAPL----FNLINGDLCYANLAQDRIRTWSDWFDNNTRSARYR 245
Query 309 LGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGF 368
P PA GNHE N I Y+A + +P G +
Sbjct 246 ----PWMPAAGNHE----NEVGNGPIG--------YDAYQTYFA--VPDSGSSPQLRGLW 287
Query 369 YALSPYPGLRLISL-NMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
Y+ + +R+ISL N + C ++ + Q +WL EL A + ++
Sbjct 288 YSFTA-GSVRVISLHNDDVCYQDGGNSYVRGYSGGEQRRWLQAELANARRDSEIDWVV 344
>sp|B2W0D9|STS1_PYRTR Tethering factor for nuclear proteasome
sts1 OS=Pyrenophora tritici-repentis (strain Pt-1C-BFP) OX=426418
GN=sts1 PE=3 SV=1
Length=310
Score = 38.2 bits (87), Expect = 0.16, Method: Composition-based stats.
Identities = 35/198 (18%), Positives = 54/198 (27%), Gaps = 36/198 (18%)
Query 177 NISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLP 236
NIS +P P P + + + H D T
Sbjct 76 NISGRPLPLPRLLETLSPDDMRNLLQ--SICQRHPDISNEIVTTAPRPSIQSTLEVLAKY 133
Query 237 PASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAH--DVWHQTRQDQ 294
AS A +G + D + L L + D H Q
Sbjct 134 EASFQAAFPFGGRASSDYAYNRVRQQLDELLDSLK--------DFTPHFLPPNEQQPATS 185
Query 295 LRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPW 354
L L T ++ + + N ++ N + YE MAKAW
Sbjct 186 LTFLDGATNIIHR----------LPNWDTFQHN----------RHKQEAYEEMAKAWAMV 225
Query 355 LPAEALRT----LRIGGF 368
+ A + L+ GG+
Sbjct 226 IQEAAKKAGGIQLQYGGW 243
>sp|O59759|YJM5_SCHPO Uncharacterized protein C1020.05 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=SPCC1020.05
PE=3 SV=1
Length=509
Score = 38.6 bits (88), Expect = 0.19, Method: Composition-based stats.
Identities = 51/292 (17%), Positives = 89/292 (30%), Gaps = 73/292 (25%)
Query 195 APGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDL 254
+IL L+DLH+ +D C DP ++ A
Sbjct 202 DEEKKTIKILQLSDLHY-----SNSDRPCRDPYPYETAEDCMADAKTTA----------- 245
Query 255 PLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPV 314
+ LL D V TGD+ D +R + + V+ V VP
Sbjct 246 ---FVNELLQ----LEEPDFVLLTGDLINGDT---SRDARSSLMKAVSPFVDY---NVPF 292
Query 315 YPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPY 374
GNH+ G+ S L + +++ + + G + L
Sbjct 293 AVNFGNHD-----------DLGDLSREELAKILSQIPG---SMGLIGNVSGVGNFVLHSP 338
Query 375 PGLRLISLNMNFCSRENFWLLINSTDPA------GQLQWLVGELQAAEDRGDKVHIIGHI 428
+ L+ N L P QL+WL ++ + ++ ++ HI
Sbjct 339 RKFAIYVLDTK-GDTSNRRLC-----PGYDAITEDQLEWLSSKVADFKYEPIQMAVL-HI 391
Query 429 P----------PGHCLKSWSW-----NYYRIVARYENTLAAQFFGHTHVDEF 465
P G + S+ N + + + GH HV++F
Sbjct 392 PLKEFCETEDLVGAFREPCSYSICDPNTAKALKSLR--IPLAIAGHDHVNDF 441
>sp|E3RPB1|STS1_PYRTT Tethering factor for nuclear proteasome
sts1 OS=Pyrenophora teres f. teres (strain 0-1) OX=861557 GN=sts1
PE=3 SV=1
Length=310
Score = 37.4 bits (85), Expect = 0.34, Method: Composition-based stats.
Identities = 35/198 (18%), Positives = 54/198 (27%), Gaps = 36/198 (18%)
Query 177 NISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLP 236
NIS +P P P + + + H D T
Sbjct 76 NISGRPLPLPRLLETLSPDEMRNLLQ--SICQRHPDISNEIVTTAPRPSIQSTLEVLAKY 133
Query 237 PASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAH--DVWHQTRQDQ 294
AS A +G + D + L L + D H Q
Sbjct 134 EASFQAAFPFGGRASSDYAYNRVRQQLDELLDSLK--------DFTPHFLPPNEQQPATS 185
Query 295 LRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPW 354
L L T ++ + + N ++ N + YE MAKAW
Sbjct 186 LAFLDGATDIIHR----------LPNWDTFQHN----------RHKQEAYEEMAKAWAIV 225
Query 355 LPAEALRT----LRIGGF 368
+ A + L+ GG+
Sbjct 226 IREAAKKAGGIQLQYGGW 243
>sp|A2RSY6|TRM1L_MOUSE TRMT1-like protein OS=Mus musculus OX=10090
GN=Trmt1l PE=1 SV=1
Length=728
Score = 37.4 bits (85), Expect = 0.44, Method: Composition-based stats.
Identities = 34/201 (17%), Positives = 61/201 (30%), Gaps = 22/201 (11%)
Query 168 GHWDIFSSWNISLPTVPKPPPKPPSPPAP---GAPVSRILFLTDLHWDHDYLEGTDPDCA 224
G D SS N P P P + L +LHW C
Sbjct 97 GDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCI 156
Query 225 DPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAH 284
L CR + G + C + T+ DM+ G + H
Sbjct 157 CHLACRPVK-PTIVGEQISSKLGAHYHCIICSATI---------TRRTDML---GHVKRH 203
Query 285 DVWHQTRQDQLRALTTVT--ALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRW 342
+T+ + A T + ++++ + V+P + S P + + + +
Sbjct 204 VNKGETKSRYIAASTAKSSNEILKETDTDIQVFP----NYSIPQKTDSYFNPKMKLNRQI 259
Query 343 LYEAMAKAWEPWLPAEALRTL 363
++ +A + P E L
Sbjct 260 IFCTLAALAKERKPLECLDAF 280
>sp|Q08I43|ERI1_SCHPO 3'-5' exonuclease eri1 OS=Schizosaccharomyces
pombe (strain 972 / ATCC 24843) OX=284812 GN=eri1 PE=1
SV=1
Length=313
Score = 37.0 bits (84), Expect = 0.50, Method: Composition-based stats.
Identities = 24/158 (15%), Positives = 55/158 (35%), Gaps = 22/158 (14%)
Query 439 WNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYR 498
+ + ++ N L VDE E+ +++ R + + + +
Sbjct 160 EELFIFLRKHSNILVPS------VDEIEIIEPLKSVPRTQPKNWAWACDGPWDMASFLAK 213
Query 499 VYQID--GNYSGSSHVVLDHETYILNLTQ---ANIPGAIPHWQLLYRARETYGLPNTLPT 553
++ D +D ++ ++ + NI G + HW L + E G+ +
Sbjct 214 QFKYDKMPIPDWIKGPFVDIRSFYKDVYRVPRTNINGMLEHWGLQFEGSEHRGIDDA--R 271
Query 554 AWHNLVYRMRGDMQLF--QTFWFLY-------HKGHPP 582
+V +M + F +W Y ++ +PP
Sbjct 272 NLSRIVKKMCSENVEFECNRWWMEYEKNGWIPNRSYPP 309
>sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein
B OS=Mus musculus OX=10090 GN=Sftpb PE=1 SV=1
Length=377
Score = 37.0 bits (84), Expect = 0.56, Method: Composition-based stats.
Identities = 26/139 (19%), Positives = 57/139 (41%), Gaps = 8/139 (6%)
Query 69 HPARLHRIVPRLRDVFGWG--NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLK 126
H + + L++V+G N C C+ + + K++ + + C++L
Sbjct 44 HAVQCRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDILP 103
Query 127 IAPP-AVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLP-TVP 184
+ C+ ++ ++ +++ + +S ++P C + C N +P VP
Sbjct 104 LKLLVPRCRQVLDVYLPLVIDYF-QSQINPKAICNHV--GLCPRGQAKPEQNPGMPDAVP 160
Query 185 KPPP-KPPSPPAPGAPVSR 202
P K P PGA ++R
Sbjct 161 NPLLDKLVLPVLPGALLAR 179
>sp|Q8H129|PPA3_ARATH Purple acid phosphatase 3 OS=Arabidopsis
thaliana OX=3702 GN=PAP3 PE=2 SV=1
Length=366
Score = 36.6 bits (83), Expect = 0.56, Method: Composition-based stats.
Identities = 15/80 (19%), Positives = 22/80 (28%), Gaps = 4/80 (5%)
Query 244 GYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTA 303
G WG + + +G D V TGD + + T
Sbjct 80 GDWGRRGS--YNQSQVALQMGEIGEKLDIDFVISTGDNFYDNGLTSLHDPLFQDSFTNIY 137
Query 304 LVRKFLGPVPVYPAVGNHES 323
P Y +GNH+
Sbjct 138 TAPSLQK--PWYSVLGNHDY 155
>sp|Q7T291|ADPRM_DANRE Manganese-dependent ADP-ribose/CDP-alcohol
diphosphatase OS=Danio rerio OX=7955 GN=adprm PE=1 SV=1
Length=322
Score = 35.9 bits (81), Expect = 1.1, Method: Composition-based stats.
Identities = 17/65 (26%), Positives = 30/65 (46%), Gaps = 7/65 (11%)
Query 403 GQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKS---WSWNY---YRIVARYENTLAAQF 456
QLQWL L ++ + ++V I H+P C +WN+ ++ +++ L
Sbjct 204 QQLQWLDAVLTLSDHKQERVLIFSHLPVHPCAADPICLAWNHEAVLSVLRSHQSVLCF-I 262
Query 457 FGHTH 461
GH H
Sbjct 263 AGHDH 267
>sp|E7QJD3|YIM1_YEASZ Protein YIM1 OS=Saccharomyces cerevisiae
(strain Zymaflore VL3) OX=764100 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|E7LYS5|YIM1_YEASV Protein YIM1 OS=Saccharomyces cerevisiae
(strain VIN 13) OX=764099 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|E7KGT3|YIM1_YEASA Protein YIM1 OS=Saccharomyces cerevisiae
(strain AWRI796) OX=764097 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|C8ZF09|YIM1_YEAS8 Protein YIM1 OS=Saccharomyces cerevisiae
(strain Lalvin EC1118 / Prise de mousse) OX=643680 GN=YIM1
PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|B5VPS4|YIM1_YEAS6 Protein YIM1 OS=Saccharomyces cerevisiae
(strain AWRI1631) OX=545124 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|C7GQ91|YIM1_YEAS2 Protein YIM1 OS=Saccharomyces cerevisiae
(strain JAY291) OX=574961 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|B3LM39|YIM1_YEAS1 Protein YIM1 OS=Saccharomyces cerevisiae
(strain RM11-1a) OX=285006 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.9 bits (81), Expect = 1.2, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + ++ +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|Q9SCX8|PPA17_ARATH Purple acid phosphatase 17 OS=Arabidopsis
thaliana OX=3702 GN=PAP17 PE=2 SV=1
Length=338
Score = 35.5 bits (80), Expect = 1.5, Method: Composition-based stats.
Identities = 20/107 (19%), Positives = 33/107 (31%), Gaps = 18/107 (17%)
Query 244 GYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDI-------PAHDVWHQTRQDQLR 296
G WG + + +G D V TGD HD +
Sbjct 52 GDWGRRGS--FNQSLVAYQMGKIGEKIDLDFVVSTGDNFYDNGLFSEHDPN---FEQSFS 106
Query 297 ALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWL 343
+ T +L +++ Y +GNH+ + SRW+
Sbjct 107 NIYTAPSLQKQW------YSVLGNHDYRGDAEAQLSSVLREIDSRWI 147
>sp|A6ZML0|YIM1_YEAS7 Protein YIM1 OS=Saccharomyces cerevisiae
(strain YJM789) OX=307796 GN=YIM1 PE=3 SV=1
Length=365
Score = 35.1 bits (79), Expect = 2.0, Method: Composition-based stats.
Identities = 25/145 (17%), Positives = 49/145 (34%), Gaps = 12/145 (8%)
Query 290 TRQDQLRALTTVTALVRKFLGPVP---VYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYE 345
D+ + V L + L ++ +VGNH+ PV + F P + +
Sbjct 217 VPYDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGN 276
Query 346 AMAKA----WEPWLP----AEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLIN 397
A W ++ +A+ + + PYP I + + + I+
Sbjct 277 NKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPID 336
Query 398 STDPAGQLQWLVGELQAAEDRGDKV 422
S Q + + L + +G V
Sbjct 337 SVYEFDQYKEAIDRLISNRAKGKVV 361
>sp|P28625|YIM1_YEAST Protein YIM1 OS=Saccharomyces cerevisiae
(strain ATCC 204508 / S288c) OX=559292 GN=YIM1 PE=1 SV=2
Length=365
Score = 35.1 bits (79), Expect = 2.0, Method: Composition-based stats.
Identities = 18/98 (18%), Positives = 34/98 (35%), Gaps = 12/98 (12%)
Query 290 TRQDQLRALTTVTALVRKFLGPVP---VYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYE 345
D+ + V L + L ++ +VGNH+ PV + F P + +
Sbjct 217 VPYDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGN 276
Query 346 AMAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 277 NKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|E7NLM5|YIM1_YEASO Protein YIM1 OS=Saccharomyces cerevisiae
(strain FostersO) OX=764101 GN=YIM1 PE=3 SV=1
Length=365
Score = 34.0 bits (76), Expect = 4.7, Method: Composition-based stats.
Identities = 15/97 (15%), Positives = 32/97 (33%), Gaps = 9/97 (9%)
Query 288 HQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPV-NSFPPPFIEGNHSSRWLYEA 346
+ + + +V + + +VGNH+ PV + F P + +
Sbjct 218 PYDEGSIVENVKKLKQIVLENDKFDMIXDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNN 277
Query 347 MAKA----WEPWLP----AEALRTLRIGGFYALSPYP 375
A W ++ +A+ + + PYP
Sbjct 278 KANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYP 314
>sp|A5WBU9|CNPD3_PSYWF Probable cyclic nucleotide phosphodiesterase
PsycPRwf_0181 OS=Psychrobacter sp. (strain PRwf-1) OX=349106
GN=PsycPRwf_0181 PE=3 SV=1
Length=340
Score = 34.0 bits (76), Expect = 4.8, Method: Composition-based stats.
Identities = 34/185 (18%), Positives = 52/185 (28%), Gaps = 34/185 (18%)
Query 188 PKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWG 247
PP+ + IL LTDLH + D + + + G
Sbjct 27 YHPPTEISTDDGTVNILQLTDLHL--YFDTPKATHEQDINKDSAHQTITGICQNNSAKRG 84
Query 248 EYSKCDL----------PLRTLESLL-SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLR 296
D + E+ L L D++ TGD+ + ++ Q Q +
Sbjct 85 NPHSADAINHSVTPVIHNYASFEACLTQALSEDVRCDLIVVTGDLVS-EIHPQLYQHLYQ 143
Query 297 ALTTVTALVRKFLGPVPVYPAVGNHES---------TPVNSFPPPFIEGNHSSRWLYEAM 347
L +P GNH+ SF P + SR Y
Sbjct 144 RLHQ---------SGIPFACIAGNHDVTDEIGKDLPFEQRSFEPHEPDSRLLSR--YSMK 192
Query 348 AKAWE 352
WE
Sbjct 193 LNGWE 197
>sp|Q05904|SM34_LYTPI 34 kDa spicule matrix protein OS=Lytechinus
pictus OX=7653 PE=2 SV=1
Length=335
Score = 33.2 bits (74), Expect = 7.9, Method: Composition-based stats.
Identities = 20/90 (22%), Positives = 31/90 (34%), Gaps = 2/90 (2%)
Query 154 SPSEACGLLLGSTCGHWDIFSSWNISLPTVPKP--PPKPPSPPAPGAPVSRILFLTDLHW 211
+P+ G G + + SW +PT P P P +PP APV + +T
Sbjct 111 TPAYPNGFAGFHQSGSYTSWPSWRPGMPTSGWPVNPANPWTPPPGRAPVMKGQHVTPQQP 170
Query 212 DHDYLEGTDPDCADPLCCRRGSGLPPASRP 241
G + D + R A +
Sbjct 171 GQRPNLGPEWDLVEATAMRAFVCEVAAGQN 200
Lambda K H a alpha
0.318 0.128 0.377 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0393 0.140 1.90 42.6 43.6
Effective search space used: 68951548263
Database: uniprot_sprot.fasta
Posted date: Jun 2, 2024 1:37 PM
Number of letters in database: 206,878,625
Number of sequences in database: 571,609
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40