[Multiple Alignment(many alignments)]
[Alignment Bar(many alignments)]
[show plain BLAST file]
BLASTP 2.11.0+
Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A.
Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J.
Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of
protein database search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics: Alejandro A. Schaffer,
L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri
I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids
Res. 29:2994-3005.
Database: unitmol_20240501.fasta
835,512 sequences; 240,313,072 total letters
Query= sp|P17405|ASM_HUMAN Sphingomyelin phosphodiesterase OS=Homo sapiens
OX=9606 GN=SMPD1 PE=1 SV=5
Length=631
Score E
Sequences producing significant alignments: (Bits) Value
5jg8_B B Sphingomyelin phosphodiesterase 1092 0.0
5jg8_A A Sphingomyelin phosphodiesterase 1090 0.0
5i8r_C C Sphingomyelin phosphodiesterase 1087 0.0
5i81_A A Sphingomyelin phosphodiesterase 1087 0.0
5i8r_B B Sphingomyelin phosphodiesterase 1087 0.0
5i85_A A Sphingomyelin phosphodiesterase 1087 0.0
5i8r_A A Sphingomyelin phosphodiesterase 1087 0.0
5fic_B B Sphingomyelin phosphodiesterase 933 0.0
5fic_A A Sphingomyelin phosphodiesterase 933 0.0
5fic_C C Sphingomyelin phosphodiesterase 933 0.0
5fic_D D Sphingomyelin phosphodiesterase 933 0.0
5fi9_B B Sphingomyelin phosphodiesterase 932 0.0
5fib_A A Sphingomyelin phosphodiesterase 931 0.0
5fib_B B Sphingomyelin phosphodiesterase 931 0.0
5fi9_A A Sphingomyelin phosphodiesterase 916 0.0
5hqn_B B Sphingomyelin phosphodiesterase 785 0.0
5hqn_A A Sphingomyelin phosphodiesterase 785 0.0
5fcb_A A Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fca_B B Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fc1_A A Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fc5_A A Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fca_A A Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fc6_A A Acid sphingomyelinase-like phosphodiesterase 3a 181 2e-49
5fc7_A A Acid sphingomyelinase-like phosphodiesterase 3a 180 6e-49
8w6p_A A Acid sphingomyelinase-like phosphodiesterase 3a 178 2e-48
8w6p_B B Acid sphingomyelinase-like phosphodiesterase 3a 178 2e-48
8w6r_A A Acid sphingomyelinase-like phosphodiesterase 3a 177 3e-48
5ebb_A A Acid sphingomyelinase-like phosphodiesterase 3a 177 5e-48
5ebb_B B Acid sphingomyelinase-like phosphodiesterase 3a 177 5e-48
5ebb_C C Acid sphingomyelinase-like phosphodiesterase 3a 177 5e-48
5ebe_C C Acid sphingomyelinase-like phosphodiesterase 3a 177 5e-48
5ebe_B B Acid sphingomyelinase-like phosphodiesterase 3a 177 5e-48
5ebe_A A Acid sphingomyelinase-like phosphodiesterase 3a 176 7e-48
5kar_A A Acid sphingomyelinase-like phosphodiesterase 3b 173 2e-46
5kas_A A Acid sphingomyelinase-like phosphodiesterase 3b 173 2e-46
>5jg8_B B Sphingomyelin phosphodiesterase
Length=586
Score = 1092 bits (2824), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 530/530 (100%), Positives = 530/530 (100%), Gaps = 0/530 (0%)
Query 84 FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDD 143
FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDD
Sbjct 39 FGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDD 98
Query 144 MVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRI 203
MVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRI
Sbjct 99 MVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRI 158
Query 204 LFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLL 263
LFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLL
Sbjct 159 LFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLL 218
Query 264 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 323
SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES
Sbjct 219 SGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHES 278
Query 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 383
TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN
Sbjct 279 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLN 338
Query 384 MNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYR 443
MNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYR
Sbjct 339 MNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYR 398
Query 444 IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQID 503
IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQID
Sbjct 399 IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQID 458
Query 504 GNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMR 563
GNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMR
Sbjct 459 GNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMR 518
Query 564 GDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
GDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 519 GDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 568
>5jg8_A A Sphingomyelin phosphodiesterase
Length=586
Score = 1090 bits (2819), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 529/529 (100%), Positives = 529/529 (100%), Gaps = 0/529 (0%)
Query 85 GWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDM 144
GWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDM
Sbjct 40 GWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDM 99
Query 145 VEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRIL 204
VEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRIL
Sbjct 100 VEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRIL 159
Query 205 FLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLS 264
FLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLS
Sbjct 160 FLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLS 219
Query 265 GLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHEST 324
GLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHEST
Sbjct 220 GLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHEST 279
Query 325 PVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNM 384
PVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNM
Sbjct 280 PVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNM 339
Query 385 NFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRI 444
NFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRI
Sbjct 340 NFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRI 399
Query 445 VARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDG 504
VARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDG
Sbjct 400 VARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDG 459
Query 505 NYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG 564
NYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG
Sbjct 460 NYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRG 519
Query 565 DMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
DMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 520 DMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 568
>5i8r_C C Sphingomyelin phosphodiesterase
Length=583
Score = 1087 bits (2812), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 528/528 (100%), Positives = 528/528 (100%), Gaps = 0/528 (0%)
Query 86 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 145
WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV
Sbjct 38 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 97
Query 146 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 205
EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF
Sbjct 98 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 157
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG
Sbjct 158 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 217
Query 266 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 325
LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP
Sbjct 218 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 277
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 385
VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN
Sbjct 278 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 337
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 445
FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV
Sbjct 338 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 397
Query 446 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 505
ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN
Sbjct 398 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 457
Query 506 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 565
YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD
Sbjct 458 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 517
Query 566 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 518 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 565
>5i81_A A Sphingomyelin phosphodiesterase
Length=583
Score = 1087 bits (2812), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 528/528 (100%), Positives = 528/528 (100%), Gaps = 0/528 (0%)
Query 86 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 145
WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV
Sbjct 38 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 97
Query 146 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 205
EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF
Sbjct 98 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 157
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG
Sbjct 158 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 217
Query 266 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 325
LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP
Sbjct 218 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 277
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 385
VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN
Sbjct 278 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 337
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 445
FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV
Sbjct 338 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 397
Query 446 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 505
ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN
Sbjct 398 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 457
Query 506 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 565
YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD
Sbjct 458 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 517
Query 566 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 518 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 565
>5i8r_B B Sphingomyelin phosphodiesterase
Length=583
Score = 1087 bits (2812), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 528/528 (100%), Positives = 528/528 (100%), Gaps = 0/528 (0%)
Query 86 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 145
WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV
Sbjct 38 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 97
Query 146 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 205
EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF
Sbjct 98 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 157
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG
Sbjct 158 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 217
Query 266 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 325
LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP
Sbjct 218 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 277
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 385
VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN
Sbjct 278 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 337
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 445
FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV
Sbjct 338 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 397
Query 446 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 505
ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN
Sbjct 398 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 457
Query 506 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 565
YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD
Sbjct 458 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 517
Query 566 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 518 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 565
>5i85_A A Sphingomyelin phosphodiesterase
Length=583
Score = 1087 bits (2812), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 528/528 (100%), Positives = 528/528 (100%), Gaps = 0/528 (0%)
Query 86 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 145
WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV
Sbjct 38 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 97
Query 146 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 205
EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF
Sbjct 98 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 157
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG
Sbjct 158 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 217
Query 266 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 325
LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP
Sbjct 218 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 277
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 385
VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN
Sbjct 278 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 337
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 445
FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV
Sbjct 338 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 397
Query 446 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 505
ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN
Sbjct 398 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 457
Query 506 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 565
YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD
Sbjct 458 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 517
Query 566 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 518 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 565
>5i8r_A A Sphingomyelin phosphodiesterase
Length=583
Score = 1087 bits (2812), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 528/528 (100%), Positives = 528/528 (100%), Gaps = 0/528 (0%)
Query 86 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 145
WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV
Sbjct 38 WGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMV 97
Query 146 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 205
EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF
Sbjct 98 EVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILF 157
Query 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265
LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG
Sbjct 158 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 217
Query 266 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 325
LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP
Sbjct 218 LGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTP 277
Query 326 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 385
VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN
Sbjct 278 VNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMN 337
Query 386 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 445
FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV
Sbjct 338 FCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIV 397
Query 446 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 505
ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN
Sbjct 398 ARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGN 457
Query 506 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 565
YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD
Sbjct 458 YSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGD 517
Query 566 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 518 MQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 565
>5fic_B B Sphingomyelin phosphodiesterase
Length=538
Score = 933 bits (2411), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/527 (88%), Positives = 493/527 (94%), Gaps = 0/527 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 614
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 537
>5fic_A A Sphingomyelin phosphodiesterase
Length=538
Score = 933 bits (2411), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/527 (88%), Positives = 493/527 (94%), Gaps = 0/527 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 614
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 537
>5fic_C C Sphingomyelin phosphodiesterase
Length=538
Score = 933 bits (2411), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/527 (88%), Positives = 493/527 (94%), Gaps = 0/527 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 614
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 537
>5fic_D D Sphingomyelin phosphodiesterase
Length=538
Score = 933 bits (2411), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/527 (88%), Positives = 493/527 (94%), Gaps = 0/527 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 614
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 537
>5fi9_B B Sphingomyelin phosphodiesterase
Length=538
Score = 932 bits (2410), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 466/527 (88%), Positives = 493/527 (94%), Gaps = 0/527 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 614
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMP 537
>5fib_A A Sphingomyelin phosphodiesterase
Length=538
Score = 931 bits (2406), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 465/526 (88%), Positives = 492/526 (94%), Gaps = 0/526 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 536
>5fib_B B Sphingomyelin phosphodiesterase
Length=538
Score = 931 bits (2406), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 465/526 (88%), Positives = 492/526 (94%), Gaps = 0/526 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+CGHWDIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 536
>5fi9_A A Sphingomyelin phosphodiesterase
Length=538
Score = 916 bits (2367), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 460/526 (87%), Positives = 487/526 (93%), Gaps = 0/526 (0%)
Query 88 NLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEV 147
NLTCP CK LFTA+N GLKKEPNVARVGSVAIK+C +L IAP VCQS VHLFEDD+VEV
Sbjct 11 NLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEV 70
Query 148 WRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLT 207
W RSVLSPSEACGLLLGS+C FS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLT
Sbjct 71 WTRSVLSPSEACGLLLGSSCXXXXXFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLT 130
Query 208 DLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLG 267
DLHWDH+YLEGTDP CADPLCCRRGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLG
Sbjct 131 DLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLG 190
Query 268 PAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVN 327
PAGPF+MVYWTGDIPAHDVW Q+RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN
Sbjct 191 PAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVN 250
Query 328 SFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFC 387
FPPPFI+GN SS+WLYEAMAKAWEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFC
Sbjct 251 GFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFC 310
Query 388 SRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVAR 447
SRENFWLLINSTDPAGQLQWLV ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+AR
Sbjct 311 SRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIAR 370
Query 448 YENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYS 507
YENTLA QFFGHTHVDEFE+FYDEETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY
Sbjct 371 YENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYP 430
Query 508 GSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQ 567
GSSHVVLDHETYILNLTQAN G P W+ LYRARETYGLP+ +P +WHNLVYRMR D Q
Sbjct 431 GSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQ 490
Query 568 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 613
LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM
Sbjct 491 LFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLM 536
>5hqn_B B Sphingomyelin phosphodiesterase
Length=473
Score = 785 bits (2028), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 395/442 (89%), Positives = 417/442 (94%), Gaps = 0/442 (0%)
Query 171 DIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCR 230
DIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLTDLHWDH+YLEGTDP CADPLCCR
Sbjct 13 DIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCR 72
Query 231 RGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQT 290
RGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLGPAGPF+MVYWTGDIPAHDVW Q+
Sbjct 73 RGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQS 132
Query 291 RQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKA 350
RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS+WLYEAMAKA
Sbjct 133 RQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKA 192
Query 351 WEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVG 410
WEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLV
Sbjct 193 WEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVE 252
Query 411 ELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYD 470
ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+ARYENTLA QFFGHTHVDEFE+FYD
Sbjct 253 ELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYD 312
Query 471 EETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
EETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY GSSHVVLDHETYILNLTQAN G
Sbjct 313 EETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAG 372
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPC 590
P W+ LYRARETYGLP+ +P +WHNLVYRMR D QLFQTFWFLYHKGHPPSEPCGTPC
Sbjct 373 GTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPC 432
Query 591 RLATLCAQLSARADSPALCRHL 612
RLATLCAQLSARADSPALCRHL
Sbjct 433 RLATLCAQLSARADSPALCRHL 454
>5hqn_A A Sphingomyelin phosphodiesterase
Length=473
Score = 785 bits (2028), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 395/442 (89%), Positives = 417/442 (94%), Gaps = 0/442 (0%)
Query 171 DIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCR 230
DIFS+WNISLP+VPKPPPKPPSPPAPGAPVSR+LFLTDLHWDH+YLEGTDP CADPLCCR
Sbjct 13 DIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCR 72
Query 231 RGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQT 290
RGSG PP S+ GAG+WGEYSKCDLPLRTLESLL GLGPAGPF+MVYWTGDIPAHDVW Q+
Sbjct 73 RGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQS 132
Query 291 RQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKA 350
RQDQLRALTT+T LVRKFLGPVPVYPAVGNHESTPVN FPPPFI+GN SS+WLYEAMAKA
Sbjct 133 RQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKA 192
Query 351 WEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVG 410
WEPWLPA+AL TLRIGGFYAL+P PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLV
Sbjct 193 WEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVE 252
Query 411 ELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYD 470
ELQAAE+RGDKVHIIGHIPPGHCLKSWSWNYY+I+ARYENTLA QFFGHTHVDEFE+FYD
Sbjct 253 ELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYD 312
Query 471 EETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
EETLSRPLAVAFLAPSATT+I LNPGYRVYQIDGNY GSSHVVLDHETYILNLTQAN G
Sbjct 313 EETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAG 372
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPC 590
P W+ LYRARETYGLP+ +P +WHNLVYRMR D QLFQTFWFLYHKGHPPSEPCGTPC
Sbjct 373 GTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPC 432
Query 591 RLATLCAQLSARADSPALCRHL 612
RLATLCAQLSARADSPALCRHL
Sbjct 433 RLATLCAQLSARADSPALCRHL 454
>5fcb_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fca_B B Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fc1_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fc5_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fca_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fc6_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 181 bits (460), Expect = 2e-49, Method: Compositional matrix adjust.
Identities = 140/445 (31%), Positives = 213/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA AP V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPADRAPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>5fc7_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=433
Score = 180 bits (456), Expect = 6e-49, Method: Compositional matrix adjust.
Identities = 139/445 (31%), Positives = 212/445 (48%), Gaps = 46/445 (10%)
Query 191 PSPPAPGAP-VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEY 249
P PA P V + +TDLH D Y TD D +G+ AS PG +G+
Sbjct 12 PLAPAXXXPAVGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD- 63
Query 250 SKCDLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRK 307
CD P + + S + +G + WTGD P H V + ++ +T +T V+
Sbjct 64 VLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQN 123
Query 308 FLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGG 367
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GG
Sbjct 124 LFPNLQVFPALGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGG 176
Query 368 FYA--LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHII 425
FY+ ++ PGLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II
Sbjct 177 FYSQKVASNPGLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYII 235
Query 426 GHIPPGH---------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSR 476
H+P G+ + ++ I RY + +A QF+GHTH D V D+
Sbjct 236 AHVPVGYLPYATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GN 293
Query 477 PLAVAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPG 530
PL F+AP+ T G+ NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 294 PLNSVFVAPAVTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKG 349
Query 531 AIPHWQLLYRARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTP 589
+W L Y + Y + + P + + LV + D + F ++ Y + S C
Sbjct 350 E-SNWTLEYVLTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQH 408
Query 590 CRLATLCA--QLSARADSPALCRHL 612
C+ +CA L + + L +HL
Sbjct 409 CKTLQVCAIMNLDSMSYDDCLKQHL 433
>8w6p_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=413
Score = 178 bits (451), Expect = 2e-48, Method: Compositional matrix adjust.
Identities = 135/435 (31%), Positives = 208/435 (48%), Gaps = 45/435 (10%)
Query 200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTL 259
V + +TDLH D Y TD D +G+ AS PG +G+ CD P + +
Sbjct 2 VGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD-VLCDSPYQLI 53
Query 260 ESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRKFLGPVPVYPA 317
S + +G + WTGD P H V + ++ +T +T V+ + V+PA
Sbjct 54 LSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPA 113
Query 318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA--LSPYP 375
+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GGFY+ ++ P
Sbjct 114 LGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNP 166
Query 376 GLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--- 432
GLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+P G+
Sbjct 167 GLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPY 225
Query 433 ------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPS 486
+ ++ I RY + +A QF+GHTH D V D+ PL F+AP+
Sbjct 226 ATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GNPLNSVFVAPA 283
Query 487 ATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
T G+ NPG R++Q Y + +LD Y LNLT+AN+ G +W L Y
Sbjct 284 VTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKGE-SNWTLEYV 338
Query 541 ARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCA-- 597
+ Y + + P + + LV + D + F ++ Y + S C C+ +CA
Sbjct 339 LTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIM 398
Query 598 QLSARADSPALCRHL 612
L + + L +HL
Sbjct 399 NLDSMSYDDCLKQHL 413
>8w6p_B B Acid sphingomyelinase-like phosphodiesterase 3a
Length=413
Score = 178 bits (451), Expect = 2e-48, Method: Compositional matrix adjust.
Identities = 135/435 (31%), Positives = 208/435 (48%), Gaps = 45/435 (10%)
Query 200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTL 259
V + +TDLH D Y TD D +G+ AS PG +G+ CD P + +
Sbjct 2 VGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD-VLCDSPYQLI 53
Query 260 ESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRKFLGPVPVYPA 317
S + +G + WTGD P H V + ++ +T +T V+ + V+PA
Sbjct 54 LSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPA 113
Query 318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA--LSPYP 375
+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GGFY+ ++ P
Sbjct 114 LGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNP 166
Query 376 GLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--- 432
GLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+P G+
Sbjct 167 GLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPY 225
Query 433 ------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPS 486
+ ++ I RY + +A QF+GHTH D V D+ PL F+AP+
Sbjct 226 ATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GNPLNSVFVAPA 283
Query 487 ATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
T G+ NPG R++Q Y + +LD Y LNLT+AN+ G +W L Y
Sbjct 284 VTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKGE-SNWTLEYV 338
Query 541 ARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCA-- 597
+ Y + + P + + LV + D + F ++ Y + S C C+ +CA
Sbjct 339 LTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIM 398
Query 598 QLSARADSPALCRHL 612
L + + L +HL
Sbjct 399 NLDSMSYDDCLKQHL 413
>8w6r_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=422
Score = 177 bits (450), Expect = 3e-48, Method: Compositional matrix adjust.
Identities = 133/430 (31%), Positives = 206/430 (48%), Gaps = 43/430 (10%)
Query 200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTL 259
V + +TDLH D Y TD D +G+ AS PG +G+ CD P + +
Sbjct 12 VGQFWHVTDLHLDPTY-HITD-DRTKVCASSKGAN---ASNPGP--FGD-VLCDSPYQLI 63
Query 260 ESLLSGLGPAG-PFDMVYWTGDIPAHD-VWHQTRQDQLRALTTVTALVRKFLGPVPVYPA 317
S + +G + WTGD P H V + ++ +T +T V+ + V+PA
Sbjct 64 LSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPA 123
Query 318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA--LSPYP 375
+GNH+ P + P + +Y A+A W+PWL EA+ TL+ GGFY+ ++ P
Sbjct 124 LGNHDYWPQDQLPI-------VTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNP 176
Query 376 GLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGH--- 432
GLR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+P G+
Sbjct 177 GLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLENTLNSSLWNKEKVYIIAHVPVGYLPY 235
Query 433 ------CLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPS 486
+ ++ I RY + +A QF+GHTH D V D+ PL F+AP+
Sbjct 236 ATDTPAIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVLSDKN--GNPLNSVFVAPA 293
Query 487 ATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR 540
T G+ NPG R++Q Y + +LD Y LNLT+AN+ G +W L Y
Sbjct 294 VTPVKGVLQKETNNPGVRLFQ----YKPGDYTLLDMVQYYLNLTEANLKGE-SNWTLEYV 348
Query 541 ARETYGLPNTLPTAWHNLVYRM-RGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQL 599
+ Y + + P + + LV + D + F ++ Y + S C C+ +CA +
Sbjct 349 LTQAYSVADLQPKSLYALVQQFATKDSKQFLKYYHYYFVSYDSSATCDQHCKTLQVCAIM 408
Query 600 SARADSPALC 609
+ + S C
Sbjct 409 NLDSMSYDDC 418
>5ebb_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=410
Score = 177 bits (448), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 1 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGDV-LC 48
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 49 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 108
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 109 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 161
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 162 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 220
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 221 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 278
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 279 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 333
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 334 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 393
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 394 FQICAIMNLDNISYADC 410
>5ebb_B B Acid sphingomyelinase-like phosphodiesterase 3a
Length=410
Score = 177 bits (448), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 1 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGDV-LC 48
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 49 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 108
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 109 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 161
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 162 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 220
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 221 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 278
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 279 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 333
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 334 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 393
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 394 FQICAIMNLDNISYADC 410
>5ebb_C C Acid sphingomyelinase-like phosphodiesterase 3a
Length=410
Score = 177 bits (448), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 1 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGDV-LC 48
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 49 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 108
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 109 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 161
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 162 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 220
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 221 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 278
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 279 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 333
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 334 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 393
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 394 FQICAIMNLDNISYADC 410
>5ebe_C C Acid sphingomyelinase-like phosphodiesterase 3a
Length=415
Score = 177 bits (448), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 2 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGDV-LC 49
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 50 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 109
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 110 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 162
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 163 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 221
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 222 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 279
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 280 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 334
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 335 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 394
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 395 FQICAIMNLDNISYADC 411
>5ebe_B B Acid sphingomyelinase-like phosphodiesterase 3a
Length=415
Score = 177 bits (448), Expect = 5e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 2 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGDV-LC 49
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 50 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 109
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 110 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 162
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 163 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 221
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 222 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 279
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 280 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 334
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 335 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 394
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 395 FQICAIMNLDNISYADC 411
>5ebe_A A Acid sphingomyelinase-like phosphodiesterase 3a
Length=418
Score = 176 bits (447), Expect = 7e-48, Method: Compositional matrix adjust.
Identities = 135/437 (31%), Positives = 208/437 (48%), Gaps = 47/437 (11%)
Query 193 PPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKC 252
PPA G + +TDLH D Y TD D +G+ AS PG +G+ C
Sbjct 2 PPAIG----QFWHVTDLHLDPTY-HITD-DHTKVCASSKGAN---ASNPGP--FGD-VLC 49
Query 253 DLPLRTLESLLSGLGPAG-PFDMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLG 310
D P + + S + +G + WTGD P H + D + +T +T ++
Sbjct 50 DSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFP 109
Query 311 PVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYA 370
+ V+PA+GNH+ P + P + +Y A+A W+PWL EA+ TLR GGFY+
Sbjct 110 NLQVFPALGNHDYWPQDQLPV-------VTSKVYNAVANLWKPWLDEEAISTLRKGGFYS 162
Query 371 --LSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHI 428
++ P LR+ISLN N N + +N TDPA Q +WL L ++ +KV+II H+
Sbjct 163 QKVTTNPNLRIISLNTNLYYGPNI-MTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHV 221
Query 429 PPGHCLKSWSWN----YYR-----IVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLA 479
P G+ S + YY I +Y + +A QF+GHTH D V D++ P+
Sbjct 222 PVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKK--GSPVN 279
Query 480 VAFLAPSATTYIGL------NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIP 533
F+AP+ T + NPG R++Q Y + +LD Y LNLT+AN+ G
Sbjct 280 SLFVAPAVTPVKSVLEKQTNNPGIRLFQ----YDPRDYKLLDMLQYYLNLTEANLKGE-S 334
Query 534 HWQLLYRARETYGLPNTLPTAWHNLVYRMRG-DMQLFQTFWFLYHKGHPPSEPCGTPCRL 592
W+L Y +TY + + P + + L + D + F ++ + + S C C+
Sbjct 335 IWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKA 394
Query 593 ATLCAQLSARADSPALC 609
+CA ++ S A C
Sbjct 395 FQICAIMNLDNISYADC 411
>5kar_A A Acid sphingomyelinase-like phosphodiesterase 3b
Length=427
Score = 173 bits (438), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 129/435 (30%), Positives = 195/435 (45%), Gaps = 47/435 (11%)
Query 200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTL 259
+ R ++DLH D +Y DP P +G P AG WG+Y CD P +
Sbjct 12 LGRFWHISDLHLDPNYTVSKDPLQVCP-----SAGSQPVL--NAGPWGDY-LCDSPWALI 63
Query 260 ESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTT-VTALVRKFLGPVPVYPA 317
S L + P D + WTGD H + + A+ +T L+++ VY A
Sbjct 64 NSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAA 123
Query 318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS---PY 374
+GNH+ P N FP S +Y +A+ W PWL E+ + G FY+ P
Sbjct 124 LGNHDFHPKNQFPA-------QSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPS 176
Query 375 PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCL 434
R++ LN N N DP Q +WL L A G+ V++IGH+PPG
Sbjct 177 RAGRVVVLNTNLYYSNN-EQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFE 235
Query 435 K---------SWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAP 485
K S++ Y +++ ++ +A QFFGH H D F +FYD P+ V FL P
Sbjct 236 KTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYD--NTGAPINVMFLTP 293
Query 486 SA----TTYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQ 536
TT G+ NPG R+++ Y ++ + D TY LNL QAN+ P W+
Sbjct 294 GVTPWKTTLPGVVDGANNPGIRIFE----YDRATLNLKDLVTYFLNLRQANVQ-ETPRWE 348
Query 537 LLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLC 596
YR E Y +P+ ++ H + R+ + + Q + ++Y+ C CR+ +C
Sbjct 349 QEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRY-YVYNSVSYNHLTCEDSCRIEHVC 407
Query 597 AQLSARADSPALCRH 611
A ++ A C H
Sbjct 408 AIQHVAFNTYATCLH 422
>5kas_A A Acid sphingomyelinase-like phosphodiesterase 3b
Length=427
Score = 173 bits (438), Expect = 2e-46, Method: Compositional matrix adjust.
Identities = 129/435 (30%), Positives = 195/435 (45%), Gaps = 47/435 (11%)
Query 200 VSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTL 259
+ R ++DLH D +Y DP P +G P AG WG+Y CD P +
Sbjct 12 LGRFWHISDLHLDPNYTVSKDPLQVCP-----SAGSQPVL--NAGPWGDY-LCDSPWALI 63
Query 260 ESLLSGLGPAGPF-DMVYWTGDIPAHDVWHQTRQDQLRALTT-VTALVRKFLGPVPVYPA 317
S L + P D + WTGD H + + A+ +T L+++ VY A
Sbjct 64 NSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAA 123
Query 318 VGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS---PY 374
+GNH+ P N FP S +Y +A+ W PWL E+ + G FY+ P
Sbjct 124 LGNHDFHPKNQFPA-------QSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPS 176
Query 375 PGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCL 434
R++ LN N N DP Q +WL L A G+ V++IGH+PPG
Sbjct 177 RAGRVVVLNTNLYYSNN-EQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFE 235
Query 435 K---------SWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAP 485
K S++ Y +++ ++ +A QFFGH H D F +FYD P+ V FL P
Sbjct 236 KTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYD--NTGAPINVMFLTP 293
Query 486 SA----TTYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQ 536
TT G+ NPG R+++ Y ++ + D TY LNL QAN+ P W+
Sbjct 294 GVTPWKTTLPGVVDGANNPGIRIFE----YDRATLNLKDLVTYFLNLRQANVQ-ETPRWE 348
Query 537 LLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLC 596
YR E Y +P+ ++ H + R+ + + Q + ++Y+ C CR+ +C
Sbjct 349 QEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRY-YVYNSVSYNHLTCEDSCRIEHVC 407
Query 597 AQLSARADSPALCRH 611
A ++ A C H
Sbjct 408 AIQHVAFNTYATCLH 422
Lambda K H a alpha
0.322 0.139 0.468 0.792 4.96
Gapped
Lambda K H a alpha sigma
0.267 0.0410 0.140 1.90 42.6 43.6
Effective search space used: 69311759088
Database: unitmol_20240501.fasta
Posted date: May 2, 2024 10:24 AM
Number of letters in database: 240,313,072
Number of sequences in database: 835,512
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40