site aa pred_sec pred_expbur pred_accessibility pdb_asym_id hetero nucleotide compound metal otherpoly homo precipitant A C D E F G H I K L M N P Q R S T V W Y feature_table variant 1 M 0 0 0 0 0 0 0 16 0 9 60 0 0 0 0 0 0 15 0 0 INIT_MET:/note="Removed" ECO:0007744|PubMed:22814378":INIT_MET:/note="Removed" ECO:0007744|PubMed:22814378":DISORDER:predicted by DISOPRED 2 S 7 0 0 0 0 9 0 0 0 0 0 21 0 0 0 47 15 0 0 0 MOD_RES:/note="N-acetylserine" ECO:0007744|PubMed:22814378":MOD_RES:/note="N-acetylserine" ECO:0007744|PubMed:22814378":DISORDER:predicted by DISOPRED 3 S 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 79 0 0 0 0 DISORDER:predicted by DISOPRED 4 I 0 0 0 0 0 0 0 24 0 76 0 0 0 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 5 L 0 0 0 0 55 0 0 0 0 45 0 0 0 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 6 P 0 0 0 0 0 0 21 0 0 0 0 0 24 0 0 55 0 0 0 0 DISORDER:predicted by DISOPRED 7 F e 125.4 1ozj_C 0 0 0 0 79 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 8 T e 30.5 1ozj_C SMAD5_HUMAN:Mothers against decapentaplegic homolog 5[127 aa] 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 79 0 0 0 MOD_RES:/note="Phosphothreonine; by CDK2 and CDK4":MUTAGEN:/note="T->V: Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213.":MOD_RES:/note="Phosphothreonine; by CDK2 and CDK4":MUTAGEN:/note="T->V: Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213.":DISORDER:predicted by DISOPRED 9 P e 40.3 1ozj_C SMAD5_HUMAN:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa] 0 0 0 0 0 21 0 0 0 0 0 0 24 0 0 55 0 0 0 0 DISORDER:predicted by DISOPRED 10 P H e 75.2 1ozj_C 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 11 I H b 13.5 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 55 0 0 0 0 0 0 37 0 0 0 0 0 0 0 0 0 8 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 12 V H b 0.7 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 13 K H e 50.5 1ozj_C 0 0 0 0 0 0 23 0 77 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 14 R H e 42.3 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 19 0 0 0 0 0 58 23 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 15 L H b 0.6 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 16 L H b 5.6 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] GOL 0 0 0 0 0 0 0 0 0 80 20 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 17 G T e 72.6 1ozj_C PGE 0 20 0 0 0 68 0 0 12 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 18 W S e 44.6 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] PGE 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 0 80 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 19 K e 31.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] GOL 0 0 0 0 0 0 0 0 80 0 0 0 0 0 20 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 20 K e 34.4 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] PGE 0 0 0 0 0 0 0 12 20 0 0 0 0 68 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 21 G b 14.3 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa] GOL 0 0 0 0 0 93 0 0 0 0 0 0 0 0 0 7 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 22 E S e 62.3 1ozj_C CL SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa] 1 0 44 29 1 1 0 1 1 1 0 1 1 14 1 1 1 1 0 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 23 Q e 49.5 1ozj_C CL GOL 1 0 10 37 0 1 0 1 14 1 0 0 1 30 1 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 24 N e 63.6 1ozj_C CL 4 1 3 4 2 20 1 3 3 5 1 30 3 2 3 4 3 4 1 2 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 25 G H e 60.7 1ozj_C CL 4 1 2 3 2 44 1 2 3 4 1 16 2 2 2 3 3 3 1 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 26 Q H e 79.6 1ozj_C CL 4 1 2 29 2 3 1 16 3 4 1 2 2 16 2 3 3 3 1 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 27 E H e 31.2 1ozj_C CL GOL 0 0 33 50 0 0 0 0 0 0 0 0 0 0 0 16 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 28 E H e 25.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] GOL 0 0 0 81 0 0 0 0 0 0 0 0 0 0 11 8 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 29 K H e 37.7 1ozj_C 0 0 8 11 0 0 0 0 37 0 0 7 0 15 10 0 11 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 30 W H b 10.4 1ozj_C GOL 0 0 0 21 25 0 0 0 0 0 0 0 0 0 0 0 0 0 53 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 31 C H b 5.3 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa] 49 15 9 0 0 0 0 0 0 21 0 0 0 0 0 0 0 7 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 32 E H b 18.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 32 0 0 0 0 37 15 0 0 0 9 7 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 33 K H e 39.6 1ozj_C DNA:Smad binding element:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. GOL 9 0 0 0 0 0 0 0 69 0 0 0 0 0 10 0 13 0 0 0 CROSSLNK:/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)":MUTAGEN:/note="K->R: Slightly decreased monoubiquitination.":DOMAIN:/note="MH1":CROSSLNK:/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)":MUTAGEN:/note="K->R: Slightly decreased monoubiquitination.":DOMAIN:/note="MH1" 34 A H b 0.0 1ozj_C 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 35 V H b 0.0 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 9 0 0 0 0 0 23 0 0 0 0 0 0 0 0 37 32 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 36 K H e 31.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 23 31 0 0 0 0 9 0 0 0 0 0 15 0 0 0 0 21 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 37 S H e 21.9 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 21 0 0 0 0 0 0 0 0 14 0 6 0 0 0 58 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 38 L H b 1.1 1ozj_C 0 0 0 0 0 0 0 0 0 90 0 0 0 0 0 0 0 10 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 39 V H b 3.3 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 0 27 6 0 0 0 0 14 0 52 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 40 K H e 56.1 1ozj_C Smad binding element:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. 0 0 0 0 0 0 0 0 86 0 0 0 0 0 14 0 0 0 0 0 SITE:/note="Required for trimerization":MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44.":DOMAIN:/note="MH1":SITE:/note="Required for trimerization":MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44.":DOMAIN:/note="MH1" 41 K H e 28.3 1ozj_C DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP.. CL 0 0 0 0 0 0 0 0 68 0 0 0 0 0 18 0 0 14 0 0 SITE:/note="Required for interaction with DNA and JUN and for functional cooperation with JUN":MUTAGEN:/note="K->A: Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43.":DOMAIN:/note="MH1":SITE:/note="Required for interaction with DNA and JUN and for functional cooperation with JUN":MUTAGEN:/note="K->A: Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43.":DOMAIN:/note="MH1" 42 L H b 0.0 1ozj_C 14 0 0 0 0 0 0 0 0 86 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 43 K H e 58.5 1ozj_C SMAD5_HUMAN:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa] 0 0 0 0 0 0 0 6 94 0 0 0 0 0 0 0 0 0 0 0 MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44.":DOMAIN:/note="MH1":MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44.":DOMAIN:/note="MH1" 44 K H e 78.8 1ozj_C 0 0 8 36 0 0 0 0 56 0 0 0 0 0 0 0 0 0 0 0 MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43.":DOMAIN:/note="MH1":MUTAGEN:/note="K->A: Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43.":DOMAIN:/note="MH1" 45 T T e 53.9 1ozj_C 0 0 0 0 0 0 20 0 38 0 0 0 0 0 33 0 8 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 46 G T e 76.2 1ozj_C EDO 2 0 1 1 1 31 0 7 18 2 0 7 1 15 1 9 1 1 0 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 47 Q b 17.9 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] ACT:EDO 16 14 9 6 0 0 0 0 6 7 0 8 0 15 3 10 5 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 48 L H b 11.8 1ozj_C SMAD4_HUMAN:SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] PEG 0 0 8 9 14 0 7 2 0 46 13 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 49 D H e 75.9 1ozj_C 0 0 29 47 0 0 0 0 0 17 0 0 0 0 0 7 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 50 E H e 21.1 1ozj_C EDO 20 0 8 22 0 0 0 0 0 17 0 6 0 8 0 9 10 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 51 L H b 1.1 1ozj_C SMAD5_MOUSE:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 14 0 0 8 0 78 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 52 E H e 25.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 8 35 0 0 0 15 0 20 0 0 0 7 0 0 0 0 0 14 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 53 K H e 42.5 1ozj_C 7 5 14 10 6 0 0 0 15 0 0 0 0 10 9 0 15 8 0 0 MUTAGEN:/note="K->R: Slightly decreased monoubiquitination.":DOMAIN:/note="MH1":MUTAGEN:/note="K->R: Slightly decreased monoubiquitination.":DOMAIN:/note="MH1" 54 A H b 0.0 1ozj_C 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 55 I H b 1.2 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 7 0 0 0 17 0 35 0 0 0 0 0 0 0 41 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 56 T H e 26.0 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 5 0 0 20 0 0 0 14 0 0 0 0 0 0 6 31 23 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 57 T H e 47.4 1ozj_C 0 17 0 0 0 0 0 0 22 0 0 5 0 0 7 31 17 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 58 Q e 51.0 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 30 0 0 0 0 0 15 21 14 20 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 59 N e 36.4 1ozj_C 0 5 14 0 0 58 0 0 0 0 0 8 0 6 0 0 8 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 60 V T e 30.7 1ozj_C 9 3 0 0 0 0 0 3 14 0 0 0 14 22 0 0 22 13 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 61 N T e 77.0 1ozj_C 0 0 0 0 0 0 9 0 20 0 0 14 33 6 10 0 0 0 0 8 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 62 T S b 3.2 1ozj_C 0 0 0 0 0 18 0 0 0 0 0 0 0 0 0 30 52 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 63 K e 72.6 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] EDO 10 0 0 6 0 32 0 0 28 0 0 5 0 0 20 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 64 C b 10.7 1ozj_C ZN:CL SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] PEG:ACT:EDO 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1" 65 I b 0.0 1ozj_C EDO 0 14 0 0 0 0 0 19 0 10 0 0 0 0 0 0 0 57 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 66 T E b 7.8 1ozj_C PEG:ACT 0 0 0 0 0 0 0 0 0 27 0 0 14 0 0 0 58 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 67 I E b 4.1 1ozj_C CL 1 0 1 1 1 1 0 59 1 11 0 1 1 1 1 1 1 18 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 68 P E e 64.3 1ozj_C CL 14 0 1 1 1 1 0 1 1 1 0 1 59 16 1 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 69 R e 26.5 1ozj_C 1 0 1 1 1 11 0 1 6 1 0 1 1 1 71 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 70 S e 39.1 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 25 0 0 0 0 1 0 0 0 1 0 0 0 0 10 42 17 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 71 L T e 102.2 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 1 0 1 1 1 1 15 1 1 70 0 1 1 1 1 1 1 1 0 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 72 D T e 54.9 1ozj_C DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP.. 1 0 69 1 1 1 0 1 1 2 0 15 1 1 1 1 1 1 0 1 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 73 G S b 3.6 1ozj_C 1 10 1 15 0 66 0 1 1 1 0 0 1 0 1 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 74 R e 47.8 1ozj_C DNA:Smad binding element:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 0 0 10 7 0 0 0 0 14 0 0 0 0 0 68 0 0 0 0 0 MUTAGEN:/note="R->D: Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN.":DOMAIN:/note="MH1":MUTAGEN:/note="R->D: Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN.":DOMAIN:/note="MH1" 75 L E b 11.8 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP.. 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 76 Q E e 50.5 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 0 0 0 0 0 0 0 14 0 0 0 0 0 68 18 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 77 V E b 3.3 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP.. 0 0 0 0 0 14 0 6 0 18 0 0 10 0 0 0 0 52 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 78 S T e 50.8 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. GOL 22 0 0 0 0 10 8 0 0 0 0 14 10 0 0 35 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 79 H T e 91.6 1ozj_C DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP.. SMAD3_HUMAN:SMAD5_MOUSE:SMAD 3[124 aa]:SMAD 3[126 aa]:Mothers against decapentaplegic homolog 5[115 aa] GOL 7 0 0 0 14 33 35 0 0 0 0 0 0 0 0 10 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 80 R E e 39.9 1ozj_C CL SMAD5_MOUSE:Mothers against decapentaplegic homolog 5[115 aa] GOL 0 0 0 0 0 14 0 0 5 0 0 0 0 10 60 10 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 81 K E e 46.2 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP..:DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP..:DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. SMAD5_MOUSE:Mothers against decapentaplegic homolog 5[115 aa] GOL 0 0 0 0 0 0 0 0 58 0 0 0 10 0 22 0 0 0 0 10 CROSSLNK:/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)":MUTAGEN:/note="K->R: Decreased monoubiquitination.":DOMAIN:/note="MH1":CROSSLNK:/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)":MUTAGEN:/note="K->R: Decreased monoubiquitination.":DOMAIN:/note="MH1" 82 G E e 22.6 1ozj_C GOL 31 0 0 0 0 52 0 0 0 0 0 0 7 0 0 10 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 83 L b 19.7 1ozj_C DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP.. 0 0 0 0 17 0 0 14 0 45 0 0 18 0 0 0 0 6 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 84 P H b 5.4 1ozj_C 0 0 0 0 0 0 0 0 0 0 14 0 86 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 85 H H b 1.6 1ozj_C 1 15 1 1 0 1 66 1 1 1 0 0 1 11 1 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 86 V H b 5.3 1ozj_C 0 0 0 0 0 0 0 0 0 27 0 0 0 0 0 0 0 73 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 87 I H b 5.3 1ozj_C 0 0 0 0 0 0 0 44 0 42 0 0 0 0 0 0 0 14 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 88 Y H b 0.9 1ozj_C 1 0 1 1 1 1 0 1 1 29 0 1 1 1 1 1 1 1 0 59 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 89 C H b 0.0 1ozj_C 16 45 1 1 1 27 0 1 1 1 0 1 1 1 1 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 90 R H e 31.2 1ozj_C GOL 0 0 0 0 0 0 0 0 25 0 0 0 0 0 75 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 91 L H b 4.5 1ozj_C CL SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 14 0 0 0 0 0 0 6 0 43 0 0 0 0 0 0 0 37 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 92 W H b 4.8 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 52 6 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 93 R T e 24.1 1ozj_C SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:SMAD3_HUMAN:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 94 W b 18.7 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[125 aa] 0 0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 0 78 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 95 P T e 49.6 1ozj_C SMAD3_HUMAN:SMAD5_MOUSE:SMAD5_HUMAN:SMAD9_HUMAN:Mothers against decapentaplegic homolog 3[125 aa]:Mothers against decapentaplegic homolog 5[121 aa]:Mothers against decapentaplegic homolog 5[122 aa]:Mothers against decapentaplegic homolog 5[127 aa]:Mothers against decapentaplegic homolog 5[125 aa]:Mothers against decapentaplegic homolog 9[126 aa]:Mothers against decapentaplegic homolog 9[131 aa]:Mothers against decapentaplegic homolog 3[119 aa]:Mothers against decapentaplegic homolog 3[120 aa] 0 0 0 0 0 0 0 0 0 0 0 8 92 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 96 D T e 71.0 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[125 aa] 0 0 72 8 0 0 0 0 6 0 0 0 0 0 0 0 0 14 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 97 L b 2.8 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[125 aa] 0 0 0 0 0 0 0 20 0 66 8 0 0 0 0 0 0 6 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 98 H e 74.9 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[125 aa] 1 0 1 1 1 1 18 1 1 1 0 1 1 40 25 6 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 99 S S e 29.7 1ozj_C DNA (5'-D(P*TP*GP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*TP.. 0 0 0 0 0 0 27 0 9 0 0 0 0 0 0 41 8 0 0 14 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 100 H G e 31.9 1ozj_C DNA:Smad binding element:5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A..:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 11 0 0 15 0 1 30 0 14 1 0 0 13 0 0 10 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 101 H G e 62.3 1ozj_C DNA:Smad binding element:5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP..:DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP..:DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP..:DNA (5'-D(P*GP*TP*AP*TP*GP*GP*CP*GP*CP*CP*AP*TP*AP..:DNA (5'-D(P*AP*TP*CP*AP*GP*AP*CP*TP*GP*CP*CP*GP*GP..:DNA (5'-D(P*TP*TP*AP*TP*AP*GP*AP*CP*TP*GP*CP*CP*GP..:DNA (5'-D(P*GP*AP*GP*TP*GP*TP*CP*TP*GP*CP*AP*GP*AP..:DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP.. 7 0 0 0 0 0 35 0 0 0 0 23 0 0 0 24 0 10 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 102 E G e 20.6 1ozj_C 0 0 0 86 0 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 103 L E b 6.7 1ozj_C 0 0 0 0 0 0 0 0 0 68 0 0 0 0 0 0 8 24 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 104 R E e 69.2 1ozj_C 0 0 0 0 0 0 0 0 75 0 0 0 0 0 19 0 0 6 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 105 A E e 25.9 1ozj_C CL 24 0 0 0 0 0 17 0 6 0 0 0 24 0 10 20 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 106 M e 21.3 1ozj_C 0 0 0 0 0 0 0 28 0 49 6 0 0 0 0 0 0 17 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 107 E T e 90.5 1ozj_C 0 27 16 28 0 0 0 0 9 14 0 0 0 0 0 0 0 6 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 108 L T e 46.1 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] 0 19 6 7 0 10 8 2 0 5 3 3 0 6 0 0 20 2 0 9 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 109 C b 4.7 1ozj_C ZN 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1" 110 E T e 59.3 1ozj_C ZN SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] 0 0 0 31 0 0 0 0 8 0 0 0 0 24 20 16 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 111 F T e 24.9 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] PEG 0 0 0 0 30 0 22 0 0 0 0 0 0 0 0 17 6 0 0 24 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 112 A b 1.8 1ozj_C CL 45 6 0 0 7 0 0 0 0 0 0 0 21 0 0 6 5 0 0 10 DOMAIN:/note="MH1":DOMAIN:/note="MH1" A->V:LP/P:rs3879068: Loeys-Dietz syndrome 3 (LDS3) ; 113 F G b 10.5 1ozj_C CL 10 0 0 0 55 17 0 0 0 0 0 0 0 0 0 6 0 0 0 11 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 114 N G e 68.5 1ozj_C CL 18 0 15 14 0 13 0 0 10 0 0 23 0 0 0 8 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 115 M G e 41.5 1ozj_C 20 0 0 0 0 0 0 10 0 12 14 0 0 0 0 39 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 116 K e 75.5 1ozj_C PEG 0 0 18 0 0 6 20 0 46 0 0 10 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 117 K e 43.9 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] 0 9 0 0 0 18 0 0 8 0 0 0 16 22 0 22 5 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 118 D S e 85.8 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] 0 0 31 10 0 0 0 0 22 0 5 0 18 0 14 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 119 E E e 32.7 1ozj_C SMAD4_HUMAN:MH1 domain of human Smad4[122 aa]:MH1 domain of human Smad4[125 aa] PEG 0 0 8 22 0 0 0 0 0 10 8 20 0 0 0 9 18 0 0 5 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 120 V E b 1.3 1ozj_C 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 83 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 121 C E b 0.0 1ozj_C ZN 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1" 122 V b 2.0 1ozj_C 0 27 0 0 0 0 0 33 0 14 0 0 0 0 0 0 0 25 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 123 N b 0.0 1ozj_C ZN 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 124 P G b 0.8 1ozj_C 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 125 Y G b 10.4 1ozj_C 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 90 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 126 H G b 1.0 1ozj_C ZN 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105":DOMAIN:/note="MH1" 127 Y E b 3.5 1ozj_C CL 0 0 0 0 18 0 0 0 0 10 0 0 0 0 0 0 0 0 0 73 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 128 Q E e 54.6 1ozj_C 0 0 0 23 0 0 0 0 17 0 0 0 0 14 19 27 0 0 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 129 R E e 28.1 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[126 aa]:Mothers against decapentaplegic homolog 3[125 aa] 0 0 0 0 0 0 0 8 0 0 0 0 0 0 78 0 0 0 14 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 130 V e 28.0 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[126 aa]:Mothers against decapentaplegic homolog 3[125 aa] 1 0 1 1 0 1 0 1 1 24 0 0 1 0 1 1 1 68 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 131 E e 85.4 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[126 aa]:Mothers against decapentaplegic homolog 3[125 aa] 1 18 11 37 0 1 6 1 1 1 0 0 1 0 1 6 1 16 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 132 T e 97.4 1ozj_C SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[126 aa] 1 0 1 1 0 18 0 1 1 15 0 8 1 0 6 27 19 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 133 P e 55.8 5odg_A 1 0 1 1 0 7 0 1 1 1 0 6 71 0 8 1 1 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 134 V e 96.0 5odg_A SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[126 aa] 1 0 9 19 1 9 0 1 1 1 0 1 1 1 8 1 14 31 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 135 L e 117.4 5odg_A 1 0 1 1 1 1 0 16 1 31 9 1 1 1 1 19 1 14 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 136 P 1 0 9 1 1 1 0 1 1 1 0 1 70 1 1 1 8 1 0 0 DOMAIN:/note="MH1":DOMAIN:/note="MH1" 137 P 1 0 1 1 1 1 0 1 1 10 0 1 70 1 1 8 1 1 0 0 138 V 8 0 1 1 1 2 0 15 1 2 1 1 15 1 6 10 1 32 0 1 139 L 1 0 7 1 0 9 9 14 1 46 0 1 6 1 1 1 1 1 0 0 140 V 1 10 0 0 0 1 0 0 0 9 0 0 0 21 0 6 0 44 0 6 141 P 2 0 1 11 1 7 0 1 1 2 0 1 36 1 9 14 10 1 0 1 142 R 2 0 1 1 1 2 0 1 1 32 0 1 1 1 42 1 1 1 0 9 143 H 1 0 6 10 0 1 37 0 0 6 0 22 0 9 0 1 0 0 0 6 144 T 1 0 1 1 0 1 0 1 14 1 0 3 1 1 1 50 17 8 0 0 145 E 2 0 1 52 1 2 0 1 1 2 0 9 16 1 1 7 1 1 0 1 146 I 10 1 1 2 6 2 1 10 7 23 6 1 11 1 1 9 2 2 0 5 147 P 4 0 14 1 0 1 0 1 1 11 0 7 56 1 1 1 1 1 0 0 148 A 17 0 6 1 0 9 0 1 1 1 7 1 21 1 1 11 3 5 0 14 149 E 1 0 0 14 0 17 0 0 15 1 0 0 6 17 9 9 0 0 0 10 150 F 1 0 0 14 18 1 3 0 0 10 9 0 0 14 0 17 0 0 0 11 151 P 0 0 8 7 0 0 0 0 11 4 4 0 35 6 16 9 0 0 0 0 152 P 0 0 0 0 0 0 0 6 0 10 3 7 50 0 0 0 0 8 0 16 153 L 1 0 1 1 0 1 0 14 9 43 6 1 10 1 1 1 1 9 0 0 154 D 6 0 41 8 1 11 3 1 1 1 11 1 1 4 1 7 1 1 0 0 155 D 1 0 38 10 1 1 6 1 6 2 7 1 1 6 1 1 13 1 0 1 156 Y 1 0 1 1 20 1 0 1 1 14 10 9 1 1 1 8 4 1 0 27 157 S 2 0 1 13 1 9 1 1 1 2 1 4 1 1 7 38 5 11 0 1 158 H 2 0 1 2 1 2 28 1 1 2 1 1 12 1 19 9 1 2 0 13 159 S 1 0 10 1 10 1 9 1 1 10 0 1 4 1 8 26 13 1 0 1 160 I 1 0 1 14 10 1 0 20 1 2 27 1 1 1 1 16 1 1 0 1 161 P 1 0 1 9 1 1 0 1 1 2 0 1 63 1 1 1 14 1 0 1 162 E 2 1 1 24 1 9 9 1 2 8 1 17 1 14 1 2 2 2 0 1 163 N 15 1 10 2 1 2 1 1 2 3 1 38 1 9 1 2 9 2 0 1 164 T 19 1 1 10 1 2 1 9 2 3 1 1 9 1 1 2 24 12 0 1 165 N 2 1 1 2 1 2 1 1 2 3 1 30 1 10 1 13 19 2 8 1 166 F 3 1 2 3 23 3 1 2 11 11 8 2 2 9 2 3 2 3 1 10 167 P 3 1 2 2 1 3 1 2 2 3 1 2 57 2 2 10 2 2 0 1 168 A 37 0 21 5 1 2 0 1 1 10 0 1 1 1 1 13 1 1 0 1 169 G 2 1 2 2 1 28 1 2 2 3 1 9 2 1 2 39 2 2 0 1 170 I 2 0 1 1 24 1 0 29 1 11 0 1 1 1 1 9 1 13 0 1 I->V:LB/B:rs3587446: -; 171 E 2 0 9 11 1 1 4 1 11 2 0 12 5 16 11 9 1 1 0 1 172 P 2 0 1 2 8 2 1 1 1 2 1 1 39 12 1 14 9 2 0 1 DISORDER:predicted by DISOPRED 173 Q 9 13 1 1 1 1 4 1 1 2 0 19 5 19 1 1 18 1 0 1 DISORDER:predicted by DISOPRED 174 S 19 0 1 1 1 1 0 1 1 2 11 5 9 1 1 42 1 1 0 1 DISORDER:predicted by DISOPRED 175 N 6 8 19 1 1 5 11 1 1 6 0 26 1 5 1 5 1 1 0 1 DISORDER:predicted by DISOPRED 176 I 13 14 1 1 1 1 0 11 1 10 4 1 1 8 1 6 11 1 8 4 DISORDER:predicted by DISOPRED 177 P 2 0 1 1 8 1 0 1 1 2 0 1 56 1 11 9 1 1 0 1 DISORDER:predicted by DISOPRED 178 E 6 0 22 15 1 6 8 1 1 2 0 9 15 1 1 9 1 1 0 1 DISORDER:predicted by DISOPRED 179 T 11 0 1 1 1 1 0 1 1 2 0 1 13 18 1 6 38 1 0 1 MOD_RES:/note="Phosphothreonine; by CDK2, CDK4 and MAPK" ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="T->V: Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MOD_RES:/note="Phosphothreonine; by CDK2, CDK4 and MAPK" ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="T->V: Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":DISORDER:predicted by DISOPRED 180 P 2 0 1 1 1 1 0 1 1 2 0 1 56 1 1 9 1 11 0 8 DISORDER:predicted by DISOPRED 181 P 2 0 1 1 1 1 0 1 1 2 11 8 55 1 1 10 1 1 0 1 DISORDER:predicted by DISOPRED 182 P 3 1 2 2 1 3 1 2 2 3 1 2 56 2 2 10 2 2 1 1 DISORDER:predicted by DISOPRED 183 G 21 1 1 2 1 20 1 1 2 2 1 9 1 11 1 14 2 9 0 1 DISORDER:predicted by DISOPRED 184 Y 2 1 1 2 9 9 5 1 2 14 1 1 1 11 1 6 2 2 0 30 DISORDER:predicted by DISOPRED 185 L 2 1 1 2 1 2 1 24 2 22 12 1 6 1 1 14 2 6 0 1 DISORDER:predicted by DISOPRED 186 S 2 1 1 17 5 2 1 1 2 2 1 1 26 1 1 20 13 2 0 1 DISORDER:predicted by DISOPRED 187 E 14 1 9 35 1 2 1 1 2 2 1 1 13 1 1 12 2 2 0 1 DISORDER:predicted by DISOPRED 188 D 2 0 35 6 1 9 1 1 1 2 1 1 17 5 1 2 1 12 0 1 DISORDER:predicted by DISOPRED 189 G 3 1 5 6 1 46 1 2 2 11 1 1 9 1 2 2 2 2 0 1 DISORDER:predicted by DISOPRED 190 E 12 1 2 35 1 2 1 1 2 3 8 5 2 5 1 15 2 2 0 1 DISORDER:predicted by DISOPRED 191 T 2 0 9 1 13 1 0 1 1 2 4 1 5 4 1 15 29 9 0 1 DISORDER:predicted by DISOPRED 192 S 5 0 1 1 11 1 0 1 1 2 4 1 1 16 1 45 1 1 0 5 DISORDER:predicted by DISOPRED 193 D 11 0 48 1 0 4 0 1 1 1 0 1 8 5 1 1 9 8 0 0 DISORDER:predicted by DISOPRED 194 H 13 8 5 11 1 1 29 1 1 10 0 9 1 8 1 1 1 1 0 0 DISORDER:predicted by DISOPRED 195 Q 1 0 4 1 1 1 0 1 1 1 0 13 19 18 1 25 11 1 0 0 DISORDER:predicted by DISOPRED 196 M 2 0 1 2 9 9 1 1 1 16 26 1 1 5 1 2 5 6 0 9 DISORDER:predicted by DISOPRED 197 N 2 1 13 2 1 2 1 1 2 3 1 24 16 1 1 17 10 2 0 1 DISORDER:predicted by DISOPRED 198 H 2 1 2 10 1 10 18 1 2 3 5 5 5 16 1 2 9 2 0 5 DISORDER:predicted by DISOPRED 199 S 6 1 6 2 1 10 1 1 2 3 1 1 17 11 1 23 10 2 0 1 DISORDER:predicted by DISOPRED 200 M 12 1 2 10 9 2 5 1 2 3 21 5 2 9 1 2 10 2 0 1 DISORDER:predicted by DISOPRED 201 D 19 1 23 10 1 2 1 1 9 3 1 5 12 1 1 6 2 2 0 1 DISORDER:predicted by DISOPRED 202 A 12 0 1 1 8 15 11 1 1 6 0 1 13 1 1 1 24 1 0 1 DISORDER:predicted by DISOPRED 203 G 2 1 17 2 1 33 1 1 2 6 1 20 1 1 1 6 2 2 0 1 DISORDER:predicted by DISOPRED 204 S 6 1 1 2 1 2 1 9 2 2 1 1 12 9 1 36 11 2 0 1 MOD_RES:/note="Phosphoserine; by GSK3 and MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MOD_RES:/note="Phosphoserine; by GSK3 and MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":DISORDER:predicted by DISOPRED 205 P 3 1 2 6 1 13 1 2 2 3 1 11 43 1 2 2 2 2 0 1 DISORDER:predicted by DISOPRED 206 N 2 0 1 5 1 1 0 1 1 2 0 27 8 13 1 9 5 11 0 10 DISORDER:predicted by DISOPRED 207 L 2 0 1 5 1 9 0 1 1 41 8 1 1 5 1 12 1 10 0 1 DISORDER:predicted by DISOPRED 208 S 15 0 1 1 1 1 11 5 1 6 4 1 1 1 1 31 10 9 0 1 MOD_RES:/note="Phosphoserine; by MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MOD_RES:/note="Phosphoserine; by MAPK" ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":MUTAGEN:/note="S->A: Increased transcriptional activity. Further increased transcriptional activity; when associated with S- 208." ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:19218245":DISORDER:predicted by DISOPRED 209 P 5 0 9 1 1 6 0 1 1 2 0 1 65 1 1 1 1 1 0 1 DISORDER:predicted by DISOPRED 210 N 6 0 13 1 1 20 0 1 1 2 0 7 5 12 1 5 12 1 0 11 DISORDER:predicted by DISOPRED 211 P 13 8 1 9 1 11 0 1 1 1 0 4 23 5 1 11 8 1 0 1 DISORDER:predicted by DISOPRED 212 M 1 0 1 1 9 1 0 11 1 29 18 1 1 0 1 1 12 13 0 0 DISORDER:predicted by DISOPRED 213 S 11 0 5 5 1 5 0 1 13 1 0 1 8 1 1 29 9 8 0 0 MOD_RES:/note="Phosphoserine; by CDK2 and CDK4" ECO:0000269|PubMed:15241418":MUTAGEN:/note="S->A: Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179.":MOD_RES:/note="Phosphoserine; by CDK2 and CDK4" ECO:0000269|PubMed:15241418":MUTAGEN:/note="S->A: Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179." 214 P 9 1 9 2 1 2 1 1 2 3 1 1 47 1 6 9 2 2 0 1 215 A 15 0 1 9 6 6 1 13 1 2 1 1 1 1 1 12 16 12 0 1 DISORDER:predicted by DISOPRED 216 H 8 0 14 1 0 1 26 18 1 1 0 5 1 1 1 14 1 1 0 7 217 N 2 0 8 1 1 1 5 1 6 2 0 24 1 7 1 20 9 1 0 9 218 N 2 0 8 7 1 2 7 1 1 2 1 12 9 9 14 18 1 2 0 1 219 L ZFYV9_HUMAN:Smad anchor for receptor activation[39 aa] 2 0 1 2 1 12 1 9 1 39 1 1 8 1 5 6 7 2 0 1 220 D e 125.9 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] 8 0 61 1 1 1 0 1 1 10 0 10 1 1 1 1 1 1 0 1 221 L e 77.5 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] 8 0 1 1 15 1 0 1 1 23 9 1 8 1 1 1 1 25 0 1 222 Q e 67.9 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[193 aa] 7 0 1 17 1 1 6 1 1 2 0 17 1 26 13 1 1 1 0 1 223 P e 78.3 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] 8 0 1 1 1 1 0 1 1 2 0 1 62 14 1 1 1 1 0 1 224 V e 26.7 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa] 1 0 1 1 1 18 0 18 18 2 0 1 18 1 1 1 1 18 0 1 225 T e 69.5 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD2_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 10 6 2 14 1 2 1 8 2 3 1 1 9 1 2 5 10 2 0 21 226 Y b 17.8 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:Ski oncogene[27 aa] SMAD2_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 2 0 1 2 8 2 1 1 1 2 1 1 12 1 1 9 1 16 0 36 227 C e 27.3 1mk2_A SKI_HUMAN:Ski oncogene[27 aa] SMAD2_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 2 6 1 21 1 1 0 1 12 2 0 8 10 6 8 7 1 7 6 1 228 E e 74.4 1mk2_A SKI_HUMAN:Ski oncogene[22 aa]:Ski oncogene[27 aa] SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[192 aa] GOL 1 0 9 52 0 1 14 1 6 1 0 0 1 0 1 1 10 1 0 0 229 P b 7.8 1mk2_A SMAD3_HUMAN:Mothers against decapentaplegic homolog 3[196 aa] SMAD2_HUMAN:SMAD3_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 1 0 1 17 0 1 0 1 1 1 0 0 49 0 15 11 1 1 0 0 230 A S e 75.9 1mk2_A MAD_DROME:SMAD1_HUMAN:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa] GOL 19 0 10 1 0 1 0 1 26 1 0 0 10 11 1 18 1 1 0 0 231 F S e 53.6 1mk2_A TAR GOL 1 0 1 1 17 1 29 1 1 1 0 10 12 0 1 18 1 1 0 7 232 W b 2.8 1mk2_A SKI_HUMAN:Ski oncogene[27 aa] GOL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 233 C E b 0.0 1mk2_A 14 68 0 0 0 9 0 0 0 9 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 234 S E b 13.3 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 0 0 0 0 0 0 0 9 0 0 5 0 6 0 48 24 8 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 235 I E b 0.0 1mk2_A 0 0 0 0 0 0 0 59 0 9 0 0 0 0 0 0 0 32 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 236 S E b 7.0 1mk2_A GOL 39 0 0 0 10 0 0 17 0 0 0 0 0 0 0 10 6 18 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 237 Y E b 0.0 1mk2_A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 238 Y E b 18.7 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:SMAD7_MOUSE:SMAD4[221 aa]:SMAD1[197 aa]:SMAD1[184 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 7[180 aa] GOL 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 23 65 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 239 E E b 1.0 1mk2_A 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" E->K:LP/P:rs3879068: Loeys-Dietz syndrome 3 (LDS3) ; 240 L T e 28.7 1mk2_A 0 0 0 17 0 0 15 0 9 53 6 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 241 N T e 75.2 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa] 0 0 14 0 0 9 0 0 8 0 0 44 0 0 15 0 10 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 242 Q E e 36.7 1mk2_A 0 3 0 0 0 0 0 0 0 9 0 14 0 7 0 6 45 16 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 243 R E e 30.4 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] GOL 0 0 0 0 0 0 0 0 0 0 9 0 9 15 68 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 244 V E b 2.7 1mk2_A GOL 0 0 0 0 0 0 0 26 0 10 0 0 0 0 0 0 0 64 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 245 G E e 36.9 1mk2_A CL SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] GOL:SO4 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 246 E E e 84.4 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] CL SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL:SO4 0 0 0 67 0 0 0 0 10 0 0 0 0 0 23 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 247 T E e 34.4 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] 19 0 0 0 0 0 0 0 18 23 0 0 0 5 0 0 26 9 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 248 F E b 10.5 1mk2_A TAR SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] ACY 9 0 1 1 52 1 0 0 1 1 0 0 0 0 0 1 1 5 0 26 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 249 H E e 50.3 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] ACY 10 8 9 10 0 0 17 0 35 2 0 0 0 5 0 0 5 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 250 A E b 0.0 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 31 12 0 0 0 0 0 0 0 6 0 0 0 0 0 6 0 45 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 251 S e 31.2 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 0 0 9 0 0 0 0 10 0 0 3 0 8 0 49 0 6 0 15 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 252 Q S e 39.3 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 6 10 13 0 9 9 0 0 0 0 9 0 7 9 18 0 10 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 253 P S e 58.1 1mk2_A 0 0 0 0 0 18 9 0 0 6 0 3 31 15 5 0 14 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 254 S E e 28.1 1mk2_A SMAD2_HUMAN:SMAD7_MOUSE:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 7[180 aa] GOL 10 0 0 0 0 0 9 0 9 0 0 9 0 0 0 43 15 6 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 255 M E b 0.0 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 9 0 0 9 0 0 21 0 10 5 0 0 0 0 0 0 46 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 256 T E b 6.5 1mk2_A SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[193 aa] 1 0 0 1 0 1 10 12 0 23 0 0 0 0 0 16 35 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 257 V E b 0.0 1mk2_A 1 0 0 1 0 1 0 43 0 1 0 0 0 0 0 1 0 50 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 258 D E b 3.1 1mk2_A 1 0 86 1 1 1 0 1 1 1 0 1 1 1 1 1 1 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 259 G b 17.9 1mk2_A SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] MAD_DROME:SMAD3_HUMAN:SMAD2_HUMAN:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[202 aa] 1 0 1 1 1 78 0 9 1 1 0 1 1 1 1 1 1 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 260 F e 38.8 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 10 0 0 0 69 9 0 0 0 0 0 0 0 0 0 0 0 0 0 12 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 261 T S e 64.3 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 0 9 0 0 9 0 0 0 0 0 53 6 0 23 DOMAIN:/note="MH2":DOMAIN:/note="MH2" T->I:LP/P:rs3879068: Loeys-Dietz syndrome 3 (LDS3) ; 262 D S e 45.1 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 0 9 72 0 0 10 0 0 0 0 0 9 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 263 P e 69.8 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 10 0 0 0 0 0 0 0 0 23 0 0 49 0 0 18 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 264 S e 37.5 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[241 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD4[221 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 0 5 0 26 0 0 0 0 0 0 0 0 23 0 0 46 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 265 N B e 35.8 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa] SMAD2_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] ACY:GOL 0 0 10 0 0 6 0 0 0 0 0 53 0 23 0 0 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 266 S T e 48.4 1mk2_A SMAD1_HUMAN:Mothers against decapentaplegic homolog 1[200 aa] ACY:GOL 1 0 1 19 0 34 0 0 1 1 0 14 0 0 9 17 1 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 267 E T e 22.1 1mk2_A SMAD7_MOUSE:SMAD2_HUMAN:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] 1 10 9 8 0 9 0 0 7 1 0 20 0 0 7 24 1 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 268 R E e 25.7 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 0 0 0 0 0 23 0 0 5 0 0 0 0 0 72 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 269 F E b 4.8 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] GOL 0 3 0 0 58 0 0 11 0 9 10 0 0 0 0 0 0 0 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 270 C E b 1.3 1mk2_A MAD_DROME:Protein mothers against dpp[199 aa] GOL 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 271 L b 0.6 1mk2_A 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 272 G T e 22.6 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD3_HUMAN:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[184 aa]:Smad2[203 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 0 10 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 273 L T e 53.9 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 9 0 0 0 0 0 0 0 0 35 0 0 0 38 0 10 0 0 9 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 274 L b 19.1 1mk2_A TAR CL SMAD4_HUMAN:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa] GOL:SO4 0 0 0 9 5 0 0 0 0 67 0 0 0 10 0 0 0 0 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 275 S e 78.1 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] SO4:GOL 0 0 0 0 0 0 0 0 0 0 0 32 19 0 0 43 6 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 276 N b 13.3 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa] SO4:GOL 0 0 0 0 0 0 0 0 0 15 0 67 0 0 0 18 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 277 V T e 97.3 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] SO4:GOL 1 0 9 16 0 1 0 1 1 1 0 0 18 0 1 1 1 50 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 278 N T e 69.1 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 14 9 0 0 0 57 0 10 0 10 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 279 R e 24.1 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] TAR SMAD4_HUMAN:SMA4_HUMAN:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD4[190 aa] SO4:GOL 0 0 0 0 0 0 0 0 8 0 0 0 0 0 92 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" R->K:LP/P:rs3879068: Loeys-Dietz syndrome 3 (LDS3) ; 280 N e 41.8 1mk2_A 0 0 0 9 0 0 0 0 0 0 0 45 0 0 0 32 14 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 281 A H e 62.5 1mk2_A 12 0 0 29 0 6 0 0 0 0 0 0 18 8 0 26 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 282 A H e 50.0 1mk2_A 19 0 0 0 0 0 0 0 10 8 0 0 0 9 0 10 35 9 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 283 V H b 1.3 1mk2_A 9 0 0 0 0 0 0 33 0 0 0 0 0 0 0 18 9 30 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 284 E H e 39.2 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa]:Mothers against decapentaplegic homolog 2[194 aa] GOL 9 0 0 49 9 0 0 0 0 0 0 0 0 8 15 10 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 285 L H e 53.9 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD1_HUMAN:SMAD2_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa] 0 0 0 9 0 0 0 0 26 5 2 27 0 10 21 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 286 T H b 10.4 1mk2_A MAD_DROME:SMAD1_HUMAN:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa] 14 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 50 26 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 287 R H b 10.3 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[221 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" R->W:LP/P:rs3879068: Loeys-Dietz syndrome 3 (LDS3) ; 288 R T e 64.0 1mk2_A SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD4[221 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 9 0 9 9 6 6 10 0 0 28 23 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 289 H T e 50.8 1mk2_A SKI_HUMAN:SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:SKIL_HUMAN:Ski oncogene[97 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] 9 0 0 0 0 0 49 0 23 9 0 0 0 0 0 0 10 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 290 I T b 0.6 1mk2_A 0 0 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 10 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 291 G T e 27.4 1mk2_A SMAD4_HUMAN:SMAD1_HUMAN:SMAD4[249 aa]:SMAD4[241 aa]:SMAD4[242 aa]:SMAD4[236 aa]:SMAD1[198 aa] 0 0 0 0 0 91 0 0 0 0 0 0 0 0 0 0 0 9 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 292 R T e 58.5 1mk2_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD1[197 aa]:SMAD1[198 aa]:Mothers against decapentaplegic homolog 2[193 aa] 10 8 9 0 10 0 0 0 37 0 0 5 0 0 16 0 0 0 0 5 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 293 G b 0.0 1mk2_A 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 294 V E b 0.0 1mk2_A 0 0 0 0 0 0 0 49 0 0 0 0 0 0 0 0 0 51 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 295 R E e 32.8 1mk2_A SMAD1_HUMAN:SMAD2_HUMAN:SMAD1[197 aa]:Mothers against decapentaplegic homolog 2[193 aa] GOL 0 0 0 9 0 0 16 0 5 15 0 0 0 30 25 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 296 L E b 0.0 1mk2_A 0 0 0 0 18 0 0 0 0 82 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 297 Y E e 30.0 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD1_HUMAN:SMAD1[197 aa] GOL 18 0 6 6 0 0 0 0 0 0 0 0 0 0 0 15 13 0 0 42 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 298 Y E b 10.4 1mk2_A SKI_HUMAN:CBP_HUMAN:Ski oncogene[22 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[18 aa] GOL 0 6 0 0 0 0 9 0 24 9 0 6 0 0 8 0 0 0 0 38 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 299 I E e 53.8 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD4_HUMAN:SMAD4[249 aa] 9 0 0 33 0 0 0 7 22 9 0 0 0 0 0 0 0 21 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 300 G T e 88.1 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 9 0 18 6 0 27 0 0 0 0 0 15 15 0 0 0 3 8 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 301 G T b 1.2 1mk2_A SKI_HUMAN:CBP_HUMAN:Ski oncogene[22 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 0 0 29 0 0 71 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 302 E E b 7.5 1mk2_A 0 0 6 42 0 23 0 0 0 0 0 9 0 6 0 14 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 303 V E b 1.3 1mk2_A SKI_HUMAN:Ski oncogene[22 aa]:Ski oncogene[27 aa] 0 0 0 0 0 0 0 15 0 15 0 0 0 0 0 0 0 70 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 304 F E e 24.4 1mk2_A ZFYV9_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa] SMAD4_HUMAN:SMAD4[249 aa] 1 0 0 1 12 1 0 0 0 1 7 0 0 0 0 1 0 1 48 25 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 305 A E b 0.0 1mk2_A 44 0 0 1 0 1 0 7 0 20 0 0 0 0 0 1 0 23 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 306 E E e 22.1 1mk2_A SMAD1_HUMAN:SMAD1[197 aa] GOL 0 0 0 32 0 0 0 0 0 0 0 0 0 14 6 9 16 0 0 23 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 307 C E b 0.0 1mk2_A 0 34 0 0 0 0 0 9 0 0 0 47 0 0 0 0 0 10 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 308 L e 23.0 1mk2_A SMAD1_HUMAN:SMAD1[197 aa] 0 0 0 5 0 0 0 0 0 43 0 6 0 0 32 0 9 5 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 309 S S b 1.6 1mk2_A 0 9 0 0 0 10 0 0 0 0 9 0 0 0 0 62 10 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 310 D S e 79.6 1mk2_A SKI_HUMAN:SMAD3_HUMAN:SMAD4_HUMAN:SMAD2_HUMAN:SKIL_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 51 15 0 0 0 0 9 0 0 17 0 0 0 8 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 311 S S b 18.8 1mk2_A SKI_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:SKIL_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa] SMAD1_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD2_HUMAN:SMAD1[197 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa] SO4 0 9 0 0 0 0 21 9 0 0 6 0 0 10 0 26 2 0 0 17 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 312 A b 12.5 1mk2_A SMAD1_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa] SO4 21 0 0 0 0 0 0 10 9 0 0 0 47 0 0 14 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 313 I E b 0.0 1mk2_A 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 0 0 40 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 314 F E b 5.7 1mk2_A SMAD2_HUMAN:SMAD1_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 315 V E b 0.0 1mk2_A 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 92 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 316 Q E e 20.4 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD3_HUMAN:SMAD 3[197 aa] ACY:SO4 0 0 0 0 0 0 0 0 8 0 0 15 0 59 9 0 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 317 S b 0.0 1mk2_A 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 90 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 318 P H e 20.9 1mk2_A ACY 8 0 0 0 0 18 0 9 6 0 0 0 32 0 16 5 0 0 0 6 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 319 N H b 0.0 1mk2_A SMAD4_HUMAN:SMAD4[249 aa] 0 0 0 0 10 9 0 0 0 0 0 40 0 0 0 0 18 0 0 24 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 320 C H b 0.0 1mk2_A SKI_HUMAN:SKIL_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa] 9 34 0 0 0 0 0 0 0 51 0 0 0 0 0 0 6 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 321 N H b 5.5 1mk2_A ACY 0 0 42 0 0 0 0 0 0 0 0 53 0 0 5 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 322 Q H e 40.8 1mk2_A SMAD4_HUMAN:SMAD4[249 aa] SO4 10 0 0 0 2 0 0 0 0 6 9 8 0 27 6 0 5 0 0 27 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 323 R G b 16.2 1mk2_A SKI_HUMAN:Ski oncogene[96 aa] SMAD4_HUMAN:SMAD4[249 aa] 1 0 1 7 1 1 12 6 9 1 7 1 9 5 8 10 19 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 324 Y G e 55.2 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[91 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[116 aa] 6 0 8 0 0 10 25 0 0 10 6 14 10 0 0 0 0 0 0 7 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 325 G G e 78.6 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD4[249 aa]:SMAD 3[197 aa] 0 0 0 0 0 71 0 0 0 0 0 16 0 0 0 8 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 326 W e 38.2 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] SMAD4_HUMAN:SMAD3_HUMAN:SMAD4[249 aa]:SMAD 3[197 aa] GOL 1 0 1 1 30 11 0 1 11 11 7 1 1 1 7 9 1 1 7 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 327 H e 74.9 1mk2_A THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa] SMAD3_HUMAN:SMAD 3[197 aa] ACY 6 0 0 9 0 0 29 0 10 0 0 0 17 9 18 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 328 P T e 61.2 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD3_HUMAN:SMAD 3[197 aa] ACY 10 0 0 0 0 0 0 0 10 25 0 0 30 0 0 5 8 0 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 329 A T e 55.4 1mk2_A THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa] SMAD3_HUMAN:SMAD 3[197 aa] ACY 12 0 9 0 0 6 0 0 10 23 0 9 0 0 0 11 14 6 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 330 T e 25.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa] GOL 6 0 0 0 0 0 0 5 16 8 0 0 0 0 0 9 37 10 0 10 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 331 V b 10.7 1mk2_A SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] GOL 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 91 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 332 C E b 17.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] CL 9 30 0 0 10 0 23 0 0 0 0 0 0 0 15 9 0 5 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 333 K E e 61.8 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] CL SMAD2_HUMAN:SMAD3_HUMAN:SMAD1_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 0 0 0 0 9 0 75 0 0 0 0 0 16 0 0 0 0 0 MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409.":DOMAIN:/note="MH2":MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409.":DOMAIN:/note="MH2" 334 I E b 2.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Inner nuclear membrane protein Man1[116 aa] 0 0 0 0 0 0 0 41 0 18 0 0 0 0 0 0 9 32 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 335 P e 38.0 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] 5 0 0 0 8 0 0 0 0 0 5 0 57 10 0 0 0 0 0 15 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 336 P T e 41.9 1mk2_A SKI_HUMAN:SKIL_HUMAN:MAN1_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[124 aa] SMAD1_HUMAN:SMAD1[197 aa] 0 0 0 0 0 9 0 0 0 0 0 23 54 0 0 14 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 337 G T e 76.2 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa] GOL 0 9 0 9 0 42 6 0 15 0 0 0 0 0 2 8 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 338 C e 37.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] 15 28 0 0 8 18 0 0 0 0 0 0 0 0 0 15 0 0 0 15 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 339 N E e 51.5 1mk2_A ZFYV9_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] TAR SMAD1_HUMAN:SMAD1[197 aa] GOL 0 0 10 0 0 0 0 0 0 0 0 7 0 6 0 62 9 0 0 6 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 340 L E b 14.6 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa]:Inner nuclear membrane protein Man1[124 aa] TAR 0 0 0 0 9 0 0 38 0 35 18 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 341 K E e 27.4 1mk2_A 0 6 0 0 0 0 0 0 85 0 0 0 0 0 0 0 9 0 0 0 MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409.":DOMAIN:/note="MH2":MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409.":DOMAIN:/note="MH2" 342 I E b 0.0 1mk2_A 8 0 0 0 0 0 0 34 0 0 0 0 0 0 0 0 9 49 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 343 F E b 0.0 1mk2_A SKI_HUMAN:Ski oncogene[22 aa] 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 344 N b 12.1 1mk2_A 0 0 61 6 0 9 0 0 0 0 0 24 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 345 N H b 10.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 0 0 0 0 16 0 0 9 10 6 13 24 0 0 0 9 0 0 0 13 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 346 Q H e 63.8 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[39 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] SMAD4_HUMAN:SMAD4[249 aa] 0 0 0 33 0 0 0 0 10 0 0 7 0 24 23 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 347 E H b 17.6 1mk2_A SO4 9 0 0 24 0 0 0 5 13 19 0 0 0 25 5 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 348 F H b 0.0 1mk2_A SKI_HUMAN:Ski oncogene[22 aa]:Ski oncogene[27 aa] 8 0 0 0 53 0 0 6 0 0 9 0 0 0 5 10 0 0 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 349 A H e 26.8 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 39 5 0 10 6 5 0 0 0 0 9 0 0 0 5 13 0 0 0 8 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 350 A H e 52.7 1mk2_A CBP_HUMAN:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 7 0 0 2 0 5 0 0 9 10 0 0 6 44 0 8 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 351 L H b 10.7 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] 6 0 0 10 0 0 0 0 0 51 24 0 0 9 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 352 L H b 2.8 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[18 aa] 1 0 1 1 1 1 0 7 11 53 0 1 1 11 1 1 1 1 0 10 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 353 A H e 50.9 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 22 0 1 12 1 1 10 1 1 11 0 1 1 1 18 10 11 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 354 Q H e 54.6 1mk2_A 5 0 5 0 0 0 0 0 0 16 0 0 0 48 9 0 14 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 355 S H b 6.2 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] 24 5 0 0 0 10 0 0 0 0 0 0 5 0 8 45 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 356 V H e 27.3 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 15 6 0 10 0 0 0 0 10 10 0 0 8 0 9 5 0 24 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 357 N T e 78.2 1mk2_A CBP_HUMAN:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:CREB-binding protein[20 aa] SMAD4_HUMAN:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[242 aa] 6 0 0 9 0 10 5 0 0 15 0 34 5 0 5 9 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 358 Q T e 63.3 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD4_HUMAN:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[242 aa] SO4 6 0 24 0 0 0 14 0 9 0 0 3 10 12 5 9 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 359 G H e 36.9 1mk2_A SMAD4_HUMAN:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[242 aa] SO4 5 0 0 1 0 35 5 0 0 11 0 9 10 0 0 7 9 1 0 5 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 360 F H e 60.3 1mk2_A ZFYV9_HUMAN:SMAD4_HUMAN:Smad anchor for receptor activation[41 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD4_HUMAN:SMAD2_HUMAN:MAD_DROME:SMAD4[221 aa]:Smad2[203 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa]:Mothers against decapentaplegic homolog 2[194 aa] SO4 16 0 9 0 29 0 8 6 0 1 10 0 0 0 0 0 10 0 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 361 E H e 81.4 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:MAD_DROME:SMAD1_HUMAN:SMAD7_MOUSE:SMAD 3[197 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa] SO4 0 0 27 42 0 0 0 0 0 1 0 10 0 9 0 9 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 362 A H b 11.6 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD4_HUMAN:SMAD4[236 aa] 27 0 9 0 8 31 0 0 10 0 0 0 0 0 0 0 2 5 0 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 363 V H b 0.0 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMA4_HUMAN:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[221 aa]:SMAD4[190 aa]:Mothers against decapentaplegic homolog 7[180 aa] 5 0 0 10 0 0 0 9 0 6 8 0 10 0 0 5 0 47 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 364 Y H e 56.5 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:SMAD 3[197 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 14 0 5 0 5 0 0 0 0 6 0 8 0 0 0 10 0 51 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 365 Q G e 50.5 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD1_HUMAN:SMAD2_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD1[198 aa]:Smad2[203 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa] 10 9 21 32 0 5 0 0 0 0 0 0 0 15 9 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 366 L G b 5.6 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 0 10 0 0 0 0 0 0 59 9 0 23 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 367 T G e 20.8 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] TAR SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[198 aa]:SMAD1[197 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] SO4 9 0 0 10 0 0 0 0 0 0 0 10 0 5 14 15 24 0 8 5 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 368 R G e 49.8 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:THIO_ECOLI:FOXH1_HUMAN:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa] TAR MAD_DROME:SMAD2_HUMAN:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[192 aa] SO4:ACY 1 0 6 1 0 1 0 1 37 1 0 0 1 0 41 1 9 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 369 M G b 1.0 1mk2_A 1 0 1 1 9 9 7 1 1 7 47 0 6 0 1 1 1 1 0 10 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 370 C G b 0.0 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 1 62 1 1 8 1 5 1 1 1 0 0 1 0 1 11 5 1 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 371 T E e 23.4 1mk2_A TAR SMAD4_HUMAN:MAD_DROME:SMAD2_HUMAN:SMAD4[221 aa]:SMAD4[242 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa] 0 9 0 0 11 0 0 6 0 0 0 10 0 0 0 15 49 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 372 I E b 0.0 1mk2_A 0 0 0 0 0 0 0 53 0 6 0 0 0 0 0 0 0 41 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 373 R E e 33.2 1mk2_A SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[196 aa] TAR SMAD2_HUMAN:MAD_DROME:SMAD7_MOUSE:Smad2[203 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[194 aa] SO4:ACY:GOL 9 0 0 0 0 0 0 0 0 0 0 0 0 8 84 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 374 M E b 1.0 1mk2_A 0 0 0 0 0 0 0 38 0 0 34 0 0 0 0 0 0 28 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 375 S E b 0.8 1mk2_A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 376 F E b 1.0 1mk2_A 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 377 V S b 19.3 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] 15 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 57 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 378 K e 43.9 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 MOD_RES:/note="N6-acetyllysine":MUTAGEN:/note="K->Q: Increased transcriptional activity. No further increase in transcriptional activity with EP300.":MUTAGEN:/note="K->R: Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409.":DOMAIN:/note="MH2":MOD_RES:/note="N6-acetyllysine":MUTAGEN:/note="K->Q: Increased transcriptional activity. No further increase in transcriptional activity with EP300.":MUTAGEN:/note="K->R: Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409.":DOMAIN:/note="MH2" 379 G b 4.8 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] 9 0 0 0 0 91 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 380 W b 1.2 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD3_HUMAN:SMAD 3[197 aa] ACY:SO4 0 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0 0 0 81 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 381 G S b 13.1 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD3_HUMAN:SMAD 3[197 aa] 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 382 A T e 67.0 1mk2_A SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa] SMAD3_HUMAN:SMAD 3[197 aa] 28 0 9 34 0 0 0 0 0 0 0 0 21 8 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 383 E T e 77.9 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:MAN1_HUMAN:Madh-interacting protein[38 aa]:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Ski-like protein[91 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa]:Inner nuclear membrane protein Man1[127 aa]:Inner nuclear membrane protein Man1[116 aa] SMAD2_HUMAN:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] ACY 9 23 12 26 0 0 9 0 2 0 0 0 0 0 0 0 10 9 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 384 Y S e 27.4 1mk2_A SKI_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:SKIL_HUMAN:THIO_ECOLI:FOXH1_HUMAN:Ski oncogene[96 aa]:Ski oncogene[97 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Ski-like protein[96 aa]:Ski-like protein[91 aa]:Ski-like protein[93 aa]:Thioredoxin 1,Forkhead box protein H1[133 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4:ACY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 385 R S e 79.8 1mk2_A SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] SMAD2_HUMAN:SMAD3_HUMAN:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Mothers against decapentaplegic homolog 2[203 aa] SO4:ACY 0 0 0 9 0 0 16 0 0 0 0 0 12 13 16 25 8 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 386 R S e 30.8 1mk2_A ZFYV9_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Smad anchor for receptor activation[39 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa] CL SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 2[196 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 387 Q e 60.7 1mk2_A THIO_ECOLI:FOXH1_HUMAN:Thioredoxin 1,Forkhead box protein H1[133 aa] CL SMAD3_HUMAN:SMAD 3[197 aa] ACY:SO4 0 0 0 0 0 0 0 0 9 10 0 0 9 64 0 9 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 388 T S e 48.1 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] ACY:SO4 0 0 27 0 23 0 0 0 10 0 0 0 0 0 0 15 24 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 389 V G b 4.0 1mk2_A SMAD2_HUMAN:SMAD7_MOUSE:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 7[180 aa] ACY:SO4 0 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 0 53 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 390 T G e 39.6 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD1[197 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa] SO4 0 0 0 0 0 0 9 0 14 9 0 0 0 0 0 8 50 10 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 391 S G e 29.7 1mk2_A CL SO4 0 0 9 14 0 0 0 0 0 0 0 10 0 0 9 58 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 392 T S b 0.0 1mk2_A 0 32 0 0 0 0 0 0 0 10 0 0 0 0 0 9 49 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 393 P S b 3.9 1mk2_A 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" P->L:US:-: A colorectal cancer sample; 394 C S b 0.0 1mk2_A 0 82 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 395 W E b 5.2 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD1[198 aa]:SMAD1[197 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa]:Mothers against decapentaplegic homolog 2[193 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 396 I E b 0.0 1mk2_A 0 0 0 0 9 0 0 62 0 29 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 397 E E b 9.5 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 0 0 0 91 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 398 L E b 0.0 1mk2_A 9 0 0 0 0 0 0 50 0 23 0 0 0 0 0 0 0 19 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 399 H E e 22.5 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] GOL 0 0 0 0 0 0 43 18 9 15 0 0 0 0 6 0 9 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 400 L E b 1.7 1mk2_A SMAD7_MOUSE:Mothers against decapentaplegic homolog 7[180 aa] 0 0 0 0 8 0 0 9 0 83 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 401 N H e 21.8 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD7_MOUSE:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 7[180 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 45 0 0 0 0 49 0 0 0 5 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 402 G H b 0.0 1mk2_A SKI_HUMAN:Ski oncogene[22 aa]:Ski oncogene[27 aa] 6 0 0 11 0 28 0 11 0 0 0 21 0 0 16 0 0 7 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 403 P H b 2.3 1mk2_A 18 0 0 0 0 0 0 0 0 0 0 0 82 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 404 L H e 25.3 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 13 0 0 0 0 0 0 0 0 64 11 0 0 0 0 0 0 0 0 13 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 405 Q H e 40.3 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SKI_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Ski oncogene[22 aa]:Ski oncogene[27 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 15 0 25 0 0 0 11 0 0 0 0 0 0 49 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 406 W H b 10.0 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 0 0 0 13 13 0 0 10 0 8 0 0 0 0 0 0 0 0 48 9 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 407 L H b 0.0 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD3_HUMAN:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 0 9 0 55 13 0 0 0 0 0 0 11 0 13 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 408 D H e 60.5 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 409 K H e 44.3 1mk2_A SKI_HUMAN:CBP_HUMAN:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa] SMAD2_HUMAN:SMAD1_HUMAN:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 1[200 aa] 0 0 0 8 0 0 0 0 30 0 0 0 0 19 7 23 13 0 0 0 MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378.":DOMAIN:/note="MH2":MUTAGEN:/note="K->R: No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378.":DOMAIN:/note="MH2" 410 V H b 4.7 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 0 0 0 0 0 0 0 13 9 10 0 0 0 0 0 0 0 68 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 411 L H b 17.4 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD4[241 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[221 aa]:SMAD4[242 aa]:SMAD1[197 aa]:SMAD1[198 aa]:SMAD1[184 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[188 aa]:Protein mothers against dpp[199 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 14 0 0 0 0 76 10 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 412 T H e 51.9 1mk2_A SMAD4_HUMAN:SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 3[196 aa]:Mothers against decapentaplegic homolog 4[208 aa]:Mothers against decapentaplegic homolog 2[196 aa] SMAD4_HUMAN:SMAD1_HUMAN:SMAD2_HUMAN:SMA4_HUMAN:MAD_DROME:SMAD3_HUMAN:SMAD4[241 aa]:SMAD4[221 aa]:SMAD4[249 aa]:SMAD4[236 aa]:SMAD4[242 aa]:SMAD1[197 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 2[198 aa]:SMAD4[190 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 3[194 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[186 aa]:Mothers against decapentaplegic homolog 2[187 aa]:Mothers against decapentaplegic homolog 2[185 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[194 aa]:Mothers against decapentaplegic homolog 2[202 aa]:Mothers against decapentaplegic homolog 2[192 aa] 0 0 0 0 0 0 11 0 12 0 0 0 0 0 0 23 54 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 413 Q H e 43.9 1mk2_A ZFYV9_HUMAN:SKI_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Smad anchor for receptor activation[39 aa]:Madh-interacting protein[38 aa]:Ski oncogene[22 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:Ski oncogene[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] 0 16 0 0 0 0 0 0 0 0 0 0 0 64 0 0 20 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 414 M H e 39.1 1mk2_A ZFYV9_HUMAN:CBP_HUMAN:Smad anchor for receptor activation[41 aa]:Madh-interacting protein[38 aa]:CBP[19 aa]:CBP[20 aa]:CBP[27 aa]:CREB-binding protein[20 aa]:CREB-binding protein[18 aa] SMAD1_HUMAN:SMAD1[197 aa]:SMAD1[198 aa] 0 0 0 0 16 0 0 0 0 0 84 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 415 G e 66.7 1mk2_A SMAD1_HUMAN:SMAD1[197 aa] 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 416 S e 107.8 1mk2_A ZFYV9_HUMAN:SMAD4_HUMAN:Madh-interacting protein[38 aa]:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 19 0 0 0 0 0 0 0 0 0 0 0 12 0 0 69 0 0 0 0 MOD_RES:/note="Phosphoserine" ECO:0007744|PubMed:23186163":DOMAIN:/note="MH2":MOD_RES:/note="Phosphoserine" ECO:0007744|PubMed:23186163":DOMAIN:/note="MH2" 417 P e 62.0 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 1[200 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[203 aa]:Mothers against decapentaplegic homolog 2[202 aa] SO4 0 0 0 0 0 0 0 0 0 0 0 0 85 0 0 0 15 0 0 0 DOMAIN:/note="MH2":DOMAIN:/note="MH2" 418 S S e 100.0 6m64_A SMAD1_HUMAN:SMAD2_HUMAN:SMAD1[197 aa]:SMAD1[198 aa]:Mothers against decapentaplegic homolog 2[203 aa] SO4 0 0 0 0 0 0 31 0 0 12 0 0 38 0 0 19 0 0 0 0 MOD_RES:/note="Phosphoserine; by CK1" ECO:0000269|PubMed:18794808":MUTAGEN:/note="S->A: Increased constitutive activity.":MUTAGEN:/note="S->D: Decreased activity.":DOMAIN:/note="MH2":MOD_RES:/note="Phosphoserine; by CK1" ECO:0000269|PubMed:18794808":MUTAGEN:/note="S->A: Increased constitutive activity.":MUTAGEN:/note="S->D: Decreased activity.":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 419 I S e 79.3 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 0 0 13 0 0 0 43 0 0 38 0 0 7 0 0 DOMAIN:/note="MH2":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 420 R e 80.6 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD3_HUMAN:SMAD2_HUMAN:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Mothers against decapentaplegic homolog 2[193 aa] 8 0 0 0 0 0 0 23 0 0 0 0 50 0 19 0 0 0 0 0 DOMAIN:/note="MH2":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 421 C e 60.7 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 42 0 0 0 0 0 58 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="MH2":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 422 S e 47.7 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DOMAIN:/note="MH2":MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 423 S S e 89.9 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DOMAIN:/note="MH2":MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 424 V e 84.1 6m64_A SMAD4_HUMAN:Mothers against decapentaplegic homolog 4[193 aa]:Mothers against decapentaplegic homolog 4[208 aa] SMAD1_HUMAN:SMAD2_HUMAN:SMAD3_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Smad2[203 aa]:Mothers against decapentaplegic homolog 3[198 aa]:Mothers against decapentaplegic homolog 2[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa]:Mothers against decapentaplegic homolog 2[193 aa]:Mothers against decapentaplegic homolog 2[202 aa] 0 0 0 0 0 0 0 18 0 0 9 0 0 0 0 0 0 74 0 0 MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DOMAIN:/note="MH2":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2" 425 S e 118.8 1khu_A SMAD1_HUMAN:MAD_DROME:SMAD1[197 aa]:SMAD1[198 aa]:Protein mothers against dpp[199 aa]:Protein mothers against dpp[188 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DOMAIN:/note="MH2":MOD_RES:/note="Phosphoserine; by TGFBR1" ECO:0000255|PROSITE-ProRule:PRU00439":MUTAGEN:/note="SSVS->AAVA: Does not abolish protein nuclear export. Abolishes almost completely acetylation." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->EEVE: Forms heterotrimers." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":MUTAGEN:/note="SSVS->RRVR: Diminishes cargo protein export." ECO:0000269|PubMed:16449645, ECO:0000269|PubMed:16862174":DISORDER:predicted by DISOPRED:DOMAIN:/note="MH2"