site aa pred_sec pred_expbur pred_accessibility pdb_asym_id hetero nucleotide compound metal otherpoly homo precipitant A C D E F G H I K L M N P Q R S T V W Y feature_table variant 1 M 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 2 L 0 0 0 0 0 0 0 0 0 56 44 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 3 A 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 14 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 4 V 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 0 56 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 5 G 0 0 0 0 0 56 0 0 0 0 0 0 0 0 0 44 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 6 C 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 7 A 29 0 0 0 0 0 0 0 0 0 0 0 0 0 0 44 27 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 8 L 0 0 0 0 0 35 0 0 0 65 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 9 L 0 0 0 0 0 0 0 0 0 77 0 0 0 0 0 23 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 10 A 9 0 0 0 0 0 0 0 0 16 0 0 0 0 0 12 28 35 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 11 A 29 0 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 47 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 12 L 0 0 0 0 10 0 0 0 0 66 0 0 0 0 0 0 0 24 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 13 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 14 A 72 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 23 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 15 A 52 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 16 P 0 0 0 0 0 0 0 0 0 0 0 0 77 0 0 0 0 23 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 17 G 37 0 0 0 0 14 0 22 0 27 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 18 A 7 0 0 0 0 0 0 0 0 5 28 0 0 0 0 0 23 36 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 19 A 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 20 L e 45.5 1n26_A 0 0 0 0 0 0 0 40 0 52 9 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 21 A b 4.5 1n26_A 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 28 48 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 22 P S b 6.2 1n26_A 0 0 0 48 0 0 0 0 0 14 0 0 14 0 0 23 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 23 R S e 88.1 1n26_A 0 0 0 0 0 14 0 0 0 48 0 0 0 0 14 23 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 24 R e 73.1 1n26_A 0 0 0 34 0 7 0 0 14 0 0 0 10 0 7 28 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 25 C b 10.0 1n26_A 0 52 0 0 0 0 0 0 48 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:10066782":TOPO_DOM:/note="Extracellular":DISULFID:ECO:0000269|PubMed:10066782":TOPO_DOM:/note="Extracellular" 26 P e 42.6 1n26_A 0 0 27 0 0 0 0 0 0 0 0 21 32 0 13 7 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 27 A e 31.2 1n26_A 20 0 0 0 0 0 0 0 7 0 0 0 0 25 0 0 0 48 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 28 Q e 34.2 1n26_A 25 0 0 0 0 0 0 0 0 21 0 0 0 7 0 0 0 0 0 48 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 29 E e 84.4 1n26_A 0 0 0 27 0 0 0 3 0 0 0 0 0 0 0 0 0 45 25 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 30 V e 32.0 1n26_A 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 0 75 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 31 A e 65.2 1n26_A 27 0 0 48 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 32 R T e 91.7 1n26_A 0 0 0 0 0 0 0 0 0 39 0 13 25 7 7 0 0 9 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 33 G T e 90.5 1n26_A 0 0 55 0 0 45 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 34 V E e 24.7 1n26_A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 39 48 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 35 L E e 41.6 1n26_A 0 0 0 0 0 0 5 0 0 14 0 0 0 25 0 9 0 13 0 34 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 36 T E e 32.5 1n26_A 0 0 0 0 0 0 0 0 0 0 0 0 38 0 0 0 41 0 0 21 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 37 S E b 10.2 1n26_A 0 0 36 0 0 21 0 0 0 13 0 6 0 0 0 23 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 38 L e 37.1 1n26_A 38 0 0 0 0 0 0 0 0 43 0 0 0 19 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 39 P T e 37.2 1n26_A USTEKINUMAB FAB LIGHT CHAIN[214 aa] 4 0 0 0 0 0 0 11 0 11 0 0 74 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 40 G T e 47.6 1n26_A 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 41 D e 45.7 1n26_A TB 21 0 4 39 0 0 0 0 0 0 0 0 0 0 16 20 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 42 S e 61.7 1n26_A USTEKINUMAB FAB LIGHT CHAIN[214 aa] 0 0 8 0 0 0 0 0 4 0 14 0 11 0 8 24 32 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 43 V E b 8.0 1n26_A 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 90 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 44 T E e 39.0 1n26_A 0 0 0 0 0 0 0 0 6 0 11 10 0 10 0 0 25 39 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 45 L E b 0.0 1n26_A 10 0 0 0 0 0 0 10 0 72 8 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 46 T E e 25.3 1n26_A 0 16 0 0 0 0 0 9 8 0 0 0 0 0 2 0 65 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 47 C b 0.0 1n26_A 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 48 P T e 65.1 1n26_A 0 0 27 0 0 8 2 0 0 0 0 10 44 0 0 10 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 49 G T e 66.7 1n26_A 1 0 1 1 0 44 0 0 1 1 0 0 1 0 0 9 39 1 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 50 V S b 1.3 1n26_A 15 1 2 2 1 7 1 2 10 3 9 1 8 1 2 10 2 23 0 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 51 E e 64.8 1n26_A 2 1 10 37 1 2 1 2 2 3 1 5 2 1 2 9 17 2 0 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 52 P T e 75.2 1n26_A 26 0 1 16 1 2 1 1 1 2 1 1 31 1 1 2 1 2 8 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 53 E T e 56.3 1n26_A NAG 10 0 21 42 1 12 0 1 1 2 0 1 1 1 1 1 1 1 0 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 54 D e 32.7 1n26_A NAG 12 0 30 23 1 22 0 1 1 2 0 1 1 1 1 1 1 1 0 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 55 N e 72.1 1n26_A NAG 4 1 24 3 2 17 1 2 3 4 1 19 2 2 2 3 3 3 1 2 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: Strongly induces cleavage and sIL6R levels. No effect on IL6R signaling; when associated with A-93, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-93, A-221, A-245 and A-350.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: Strongly induces cleavage and sIL6R levels. No effect on IL6R signaling; when associated with A-93, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-93, A-221, A-245 and A-350.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 56 A S e 22.3 1n26_A 24 1 2 2 2 24 1 5 2 4 1 2 2 2 2 3 13 7 1 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 57 T E e 51.9 1n26_A 12 1 3 3 2 4 1 3 3 5 1 2 19 2 3 4 24 4 1 2 MUTAGEN:/note="T->A: Strongly induces cleavage and sIL6R levels.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="T->A: Strongly induces cleavage and sIL6R levels.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 58 V E b 0.0 1n26_A 1 0 1 1 0 1 0 50 1 11 0 1 1 1 1 1 1 29 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 59 H E e 51.3 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 1 0 1 1 0 1 18 8 1 1 0 1 1 1 1 17 37 1 0 10 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 60 W E b 0.8 1n26_A 1 0 1 1 0 1 0 0 1 1 0 0 1 0 0 1 1 1 90 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 61 V E b 3.3 1n26_A 3 1 2 3 7 3 1 2 2 7 1 2 2 2 2 3 35 20 1 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 62 L E b 2.2 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa]:Nanobody 22E11[123 aa] 4 1 3 3 9 3 1 2 3 32 1 2 2 2 8 7 3 3 1 10 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 63 R E e 37.2 1n26_A NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 4 1 15 3 2 4 1 2 3 14 1 12 3 6 18 3 3 3 1 2 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 64 K e 25.5 1n26_A 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 4 1 10 9 2 17 1 2 21 4 1 7 3 5 2 3 3 3 1 2 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 65 P S e 77.5 1n26_A 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 4 1 3 3 2 11 1 2 3 4 1 6 26 7 12 6 3 3 1 2 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 66 A S e 58.0 1n26_A 15 1 13 3 2 6 1 2 8 4 1 2 2 2 22 7 2 7 1 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 67 A S e 92.9 1n26_A 5 0 0 7 0 1 0 0 0 16 0 8 0 10 0 20 29 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 68 G S e 101.2 1n26_A 4 0 0 0 0 39 0 0 0 6 0 0 10 0 7 30 0 3 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 69 S e 32.8 1n26_A Nanobody 22E11[123 aa] 5 10 24 4 0 1 0 1 1 8 0 0 1 6 1 28 8 1 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 70 H e 56.5 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] 1 0 8 11 0 6 16 1 1 8 0 0 5 36 4 1 1 1 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 71 P e 55.0 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] 1 0 5 1 0 1 0 8 4 11 0 5 10 8 1 34 1 1 0 10 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 72 S E e 21.9 1n26_A 1 0 14 1 0 12 0 1 1 1 0 3 1 0 9 54 1 1 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 73 R E e 68.4 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 1 0 12 38 1 1 0 1 1 1 0 1 8 1 29 1 1 1 0 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 74 W E e 41.8 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 1 0 8 1 1 1 0 4 1 11 0 1 5 1 11 9 1 30 13 1 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 75 A E e 62.5 1n26_A USTEKINUMAB FAB LIGHT CHAIN[214 aa]:USTEKINUMAB FAB HEAVY CHAIN[217 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 16 0 0 0 0 0 7 0 0 39 0 9 0 0 0 11 8 8 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 76 G E b 15.5 1n26_A 0 0 0 0 0 64 0 0 9 7 0 9 0 0 0 0 8 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 77 M E e 67.6 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 0 0 0 0 0 0 23 4 7 0 0 0 34 19 12 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 78 G S b 14.3 1n26_A 0 0 0 0 0 79 0 8 6 0 0 0 0 0 0 8 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 79 R S e 24.1 1n26_A 0 0 0 0 0 0 12 0 33 8 8 7 0 0 6 11 8 0 0 6 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 80 R E e 55.3 1n26_A REGN8938 antibody Fab fragment heavy chain[214 aa].. IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 4 0 0 0 0 0 8 0 0 0 7 23 0 40 6 0 12 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 81 L E e 20.8 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 7 0 0 0 0 0 0 0 7 74 0 0 0 0 0 0 0 5 0 8 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 82 L E e 51.7 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 0 7 0 0 15 0 16 0 0 0 5 0 0 28 30 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 83 L E b 8.4 1n26_A USTEKINUMAB FAB LIGHT CHAIN[214 aa]:USTEKINUMAB FAB HEAVY CHAIN[217 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 7 0 0 0 0 26 0 49 0 0 0 0 0 0 0 18 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 84 R e 87.7 1n26_A USTEKINUMAB FAB LIGHT CHAIN[214 aa]:USTEKINUMAB FAB HEAVY CHAIN[217 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 12 0 0 0 0 0 2 0 8 3 0 7 0 34 35 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 85 S S e 41.4 1n26_A 7 5 3 0 0 7 0 0 0 0 0 5 0 12 7 16 0 39 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 86 V b 0.0 1n26_A I12R1_HUMAN:DAPK1_HUMAN:USTEKINUMAB FAB LIGHT CHAIN[214 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. 4 0 0 0 0 0 0 7 31 7 0 0 0 0 8 7 0 37 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 87 Q e 35.7 1n26_A I12R1_HUMAN:DAPK1_HUMAN:USTEKINUMAB FAB LIGHT CHAIN[214 aa]:USTEKINUMAB FAB HEAVY CHAIN[217 aa]:Nanobody 22E11[123 aa]:Briakinumab FAb Heavy chain[208 aa]:Briakinumab FAb Heavy chain[207 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. 0 8 17 38 0 0 0 0 8 5 0 7 0 11 7 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 88 L G e 45.5 1n26_A I12R1_HUMAN:Nanobody 22E11[123 aa]:Interleukin-12 receptor subunit beta-1[109 aa] 8 0 0 0 38 0 0 0 0 20 4 0 0 7 0 12 4 3 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 89 H G e 60.2 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa]:Nanobody 22E11[123 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 2 0 0 13 0 25 9 0 0 8 0 3 5 7 3 12 9 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 90 D G b 19.8 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] NA IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 72 0 0 0 13 0 0 0 0 3 0 5 0 7 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 91 S b 13.3 1n26_A Nanobody 22E11[123 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 31 0 0 12 0 14 0 5 0 0 0 0 8 0 0 24 6 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 92 G E b 3.6 1n26_A 0 0 7 0 0 86 7 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 93 N E e 35.2 1n26_A CLCF1_HUMAN:Cardiotrophin-like cytokine factor 1[178 aa] NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 3 12 0 2 6 0 0 7 0 12 0 30 0 6 12 0 2 8 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-221, A-245 and A-350.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-221, A-245 and A-350.":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 94 Y E b 0.4 1n26_A USTEKINUMAB FAB HEAVY CHAIN[217 aa] 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 12 75 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 95 S E b 9.4 1n26_A CLCF1_HUMAN:Cardiotrophin-like cytokine factor 1[178 aa] 7 0 0 0 0 0 0 4 0 6 0 6 0 0 0 22 40 15 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 96 C E b 0.7 1n26_A 0 82 0 12 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 97 Y E e 24.8 1n26_A 0 0 0 0 10 0 34 0 0 0 0 0 0 11 12 3 8 0 12 10 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 98 R S e 39.5 1n26_A 4 0 0 5 0 0 7 0 29 6 0 0 0 3 13 12 16 6 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 99 A S e 90.2 1n26_A 2 0 13 0 0 41 0 0 0 12 0 3 0 0 0 19 10 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 100 G S e 63.1 1n26_A 0 0 6 12 0 70 0 0 0 0 0 0 0 0 0 5 0 0 7 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 101 R S e 79.4 1n26_A REGN8938 antibody Fab fragment heavy chain[214 aa].. 6 0 0 25 8 0 18 0 5 6 0 0 0 0 15 7 0 11 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 102 P e 101.6 1n26_A CLCF1_HUMAN:Cardiotrophin-like cytokine factor 1[178 aa] 6 0 8 0 3 0 0 7 0 20 0 0 22 0 0 5 7 21 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 103 A S b 8.9 1n26_A REGN8938 antibody Fab fragment heavy chain[214 aa].. 5 0 0 0 0 12 0 0 5 51 0 0 0 0 6 0 8 11 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 104 G e 35.7 1n26_A 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 7 5 0 0 0 27 6 8 0 0 0 0 0 0 0 33 7 0 0 5 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 105 T E e 30.5 1n26_A CLCF1_HUMAN:Cardiotrophin-like cytokine factor 1[178 aa] 0 0 0 0 0 12 14 8 0 0 8 0 0 16 11 5 23 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 106 V E b 13.3 1n26_A Briakinumab FAb Heavy chain[208 aa]:Briakinumab FAb Heavy chain[207 aa] K:NA 0 0 0 0 0 0 0 12 0 0 3 0 0 0 0 31 10 42 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 107 H E e 41.9 1n26_A I12R1_HUMAN:IL27A_HUMAN:IL27B_MOUSE:IL27A_MOUSE:CLCF1_HUMAN:IL11_HUMAN:DAPK1_HUMAN:Nanobody 22E11[123 aa]:Briakinumab FAb Heavy chain[205 aa]:Briakinumab FAb Heavy chain[208 aa]:Briakinumab FAb Heavy chain[206 aa]:Briakinumab FAb Heavy chain[207 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-27 subunit beta,Interleukin-27 subunit..:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. NAG K 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 6 2 9 2 6 7 0 0 22 0 7 5 2 8 0 22 0 0 4 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 108 L E b 2.2 1n26_A 0 0 0 0 0 0 0 22 0 74 4 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 109 L E e 24.2 1n26_A CLCF1_HUMAN:Cardiotrophin-like cytokine factor 1[178 aa] K:NA 3 0 0 0 4 0 8 6 7 52 0 0 0 3 4 4 3 0 0 6 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 110 V E b 2.7 1n26_A Nanobody 22E11[123 aa]:Briakinumab FAb Heavy chain[208 aa] CL 0 0 0 0 0 3 0 6 2 32 0 0 0 0 0 14 2 41 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 111 D b 0.6 1n26_A 0 0 33 3 0 46 3 0 2 0 0 0 0 12 0 0 0 0 0 0 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 112 V e 40.0 1n26_A IL23A_HUMAN:Interleukin-23 subunit p19[159 aa]:ADNECTIN[91 aa] SO4 2 0 0 0 7 0 0 22 2 22 0 0 0 2 0 9 0 27 0 7 DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Ig-like C2-type":TOPO_DOM:/note="Extracellular" 113 P e 50.4 1n26_A IL23A_HUMAN:IL23R_HUMAN:ADNECTIN[91 aa]:Nanobody 37D5[122 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-23 receptor[293 aa] 6 0 7 0 4 0 0 0 3 12 0 0 64 0 0 0 0 4 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 114 P b 14.0 1n26_A IL23A_HUMAN:IL23R_HUMAN:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Briakinumab FAb Light chain[215 aa]:Briakinumab FAb Light chain[213 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-23 receptor[293 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 0 0 0 2 0 0 18 0 0 0 71 7 1 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 115 E b 19.6 1n26_A I12R1_HUMAN:DAPK1_HUMAN:ADNECTIN[91 aa]:Briakinumab FAb Light chain[215 aa]:Briakinumab FAb Light chain[213 aa]:Briakinumab FAb Light chain[214 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 9 0 20 36 0 10 0 0 15 0 0 5 0 0 5 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 116 E e 39.7 1n26_A IL23R_HUMAN:IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-23 receptor[293 aa]:Briakinumab FAb Light chain[215 aa]:Briakinumab FAb Light chain[214 aa]:Briakinumab FAb Light chain[213 aa]:H4H25311P2 antibody Fab fragment light chain[215 a..:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 0 0 6 22 0 0 0 4 29 0 0 0 6 25 9 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 117 P b 0.0 1n26_A IL23R_HUMAN:CALM1_HUMAN:Interleukin-23 receptor,Calmodulin-1[293 aa] 0 0 0 0 0 0 0 0 11 0 0 0 82 0 0 2 5 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 118 Q e 61.7 1n26_A IL23R_HUMAN:Interleukin-23 receptor[293 aa] NAG K:NA 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 0 24 6 2 0 0 21 0 0 11 0 12 13 0 2 10 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 119 L b 11.8 1n26_A 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 0 0 0 0 0 22 0 55 0 5 0 0 0 0 0 18 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 120 S E e 47.7 1n26_A NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL 0 0 0 0 4 0 1 8 21 0 3 0 0 4 3 43 11 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 121 C E b 6.7 1n26_A antibody heavy chain[220 aa] GOL:CO3:ACT 0 74 0 0 0 0 0 0 11 0 0 0 0 0 3 0 5 6 0 0 MUTAGEN:/note="C->S: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->S: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 122 F E e 23.0 1n26_A GOL:CO3 1 14 1 21 14 1 0 15 1 1 3 1 1 1 13 1 1 5 5 1 MUTAGEN:/note="F->A: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="F->A: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 123 R B b 1.6 1n26_A antibody heavy chain[220 aa] CO3 24 0 0 0 0 0 0 0 0 5 0 0 0 18 24 19 0 10 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 124 K S e 27.8 1n26_A 9 0 0 4 0 0 0 0 46 0 0 17 0 0 4 20 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 125 S S b 0.8 1n26_A Nanobody 124C4[125 aa]:antibody heavy chain[220 aa] NA GOL 3 5 6 10 0 10 0 0 0 3 0 25 12 0 4 6 11 6 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 126 P T b 0.0 1n26_A I12A_HUMAN:IL6_HUMAN:IL23A_HUMAN:IL12A_HUMAN:CLCF1_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-6[163 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Nanobody 124C4[125 aa]:Interleukin-23 subunit alpha[129 aa]:antibody heavy chain[220 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-23 subunit alpha[138 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa] NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 10 24 0 14 0 0 0 0 0 2 8 0 0 7 0 0 0 32 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 127 L T e 52.2 1n26_A IL6_HUMAN:PRL_HUMAN:IL27A_HUMAN:IL11_HUMAN:Interleukin-6[163 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-6[169 aa]:Interleukin-11[165 aa]:Interleukin-6[157 aa] NAG 12 0 1 1 0 1 0 0 16 9 5 4 12 2 5 20 1 1 0 9 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 128 S S e 30.5 1n26_A CSH_SHEEP:IL6_HUMAN:PRL_HUMAN:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:antibody heavy chain[220 aa] NAG 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 5 0 0 24 0 30 0 4 22 0 0 0 0 0 0 10 0 4 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 129 N e 35.8 1n26_A Nanobody 124C4[125 aa]:antibody heavy chain[220 aa] NAG NA 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL 4 0 5 0 0 7 7 0 3 0 0 28 0 0 13 6 26 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 130 V E b 0.0 1n26_A NA 4 0 0 0 55 0 0 8 0 5 10 0 0 0 0 0 0 18 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 131 V E b 16.7 1n26_A antibody heavy chain[220 aa] NA 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. GOL:SO4 8 0 4 0 2 2 0 2 0 6 0 0 0 0 3 12 50 2 0 7 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 132 C E b 0.0 1n26_A 0 94 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 MUTAGEN:/note="C->A: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->A: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 133 E E e 20.1 1n26_A antibody heavy chain[220 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL:CO3:ACT 3 0 0 11 0 0 0 0 0 0 0 0 0 6 5 19 16 0 40 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 134 W E b 4.8 1n26_A NA 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 96 0 MUTAGEN:/note="W->L: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="W->L: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 135 G e 40.5 1n26_A 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 3 0 11 6 0 13 7 7 9 6 0 5 1 0 7 12 10 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 136 P b 10.1 1n26_A IL23A_HUMAN:Interleukin-23 subunit alpha[155 aa] 1 0 1 1 2 4 0 1 1 5 0 0 60 0 7 10 6 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 137 R S e 73.9 1n26_A IL23A_HUMAN:Interleukin-23 subunit alpha[155 aa] SO4 6 0 1 1 0 50 0 1 1 1 0 0 5 0 9 15 8 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 138 S S e 60.2 1n26_A 10 0 12 4 0 2 0 3 4 1 0 2 5 7 15 17 4 3 0 8 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 139 T e 55.8 1n26_A 4 0 22 6 0 0 5 10 0 11 0 6 9 0 0 5 9 11 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 140 P e 20.2 1n26_A SO4 2 0 0 0 0 27 0 0 0 0 0 0 20 6 2 9 36 0 0 0 MUTAGEN:/note="P->G: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="P->G: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 141 S e 27.3 1n26_A NAG beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1.. SO4 11 0 5 6 0 36 6 0 0 0 0 15 0 0 0 10 0 0 0 10 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 142 L T e 93.3 1n26_A H4H25311P2 antibody Fab fragment heavy chain[217 a.. 0 0 0 0 5 0 2 8 0 48 0 0 6 0 0 14 9 8 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 143 T T e 27.9 1n26_A NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. PGE 0 0 0 6 12 2 0 0 4 0 0 0 24 0 0 17 28 0 0 6 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 144 T b 7.8 1n26_A H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 12 0 0 0 0 0 6 0 8 0 7 0 0 0 4 61 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 145 K E e 57.1 1n26_A NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. PGE 4 0 10 4 0 12 5 3 11 0 0 25 4 0 15 0 2 4 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 146 A E b 4.5 1n26_A H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 20 0 0 0 0 6 0 0 2 7 0 0 0 0 0 6 9 9 0 41 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 147 V E e 25.3 1n26_A LIF_HUMAN:Leukemia inhibitory factor[169 aa] NAG alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 13 0 0 3 6 0 0 0 9 9 0 7 0 0 0 8 27 18 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 148 L E b 0.0 1n26_A Q98823_HHV8:IL6_HUMAN:LIF_HUMAN:CNTF_HUMAN:IL11_HUMAN:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:H4H25311P2 antibody Fab fragment light chain[215 a..:H4H25311P2 antibody Fab fragment heavy chain[217 a..:Interleukin-6[169 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] 0 0 0 0 16 0 0 5 0 44 2 0 0 0 0 5 14 6 3 5 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 149 L E b 1.1 1n26_A LIF_HUMAN:IL11_HUMAN:Leukemia inhibitory factor[169 aa]:Interleukin-11[165 aa] CO3 4 0 0 0 6 0 8 5 4 24 0 0 0 10 0 25 9 2 0 2 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 150 V E b 0.0 1n26_A Q98823_HHV8:LIF_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:VIRAL IL-6[167 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] CO3 10 0 1 1 0 8 0 1 1 16 0 0 1 7 1 13 4 15 0 23 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 151 R E e 28.5 1n26_A IL6_HUMAN:IL6RB_HUMAN:LIF_HUMAN:CNTF_HUMAN:IL11_HUMAN:IL6RB_MOUSE:Interleukin-6[163 aa]:Interleukin-6 receptor beta chain[298 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Interleukin-6 receptor subunit beta[584 aa] NAG beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. CO3 10 0 1 1 0 1 10 1 21 1 0 5 1 0 16 15 11 1 0 7 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 152 K E b 16.0 1n26_A LIF_HUMAN:IL11_HUMAN:Leukemia inhibitory factor[169 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] 1 0 1 13 0 13 0 1 37 1 0 0 1 0 5 16 1 1 0 10 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 153 F E e 42.6 1n26_A IL6RB_HUMAN:IL6_HUMAN:CNTF_HUMAN:IL11_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:INTERLEUKIN-6[160 aa]:Ciliary neurotrophic factor[174 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[584 aa] NAG beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 2 0 1 5 10 2 3 8 21 2 3 1 11 1 10 10 1 8 0 1 MUTAGEN:/note="F->L: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="F->L: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 154 Q S e 44.9 1n26_A IL6RB_HUMAN:IL6_HUMAN:IL11_HUMAN:Interleukin-6 receptor beta chain[298 aa]:INTERLEUKIN-6[160 aa]:Interleukin-11[165 aa] 5 0 7 1 1 1 0 1 7 11 8 9 1 4 12 5 10 12 0 3 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 155 N S e 100.0 1n26_A IL6_HUMAN:IL6RB_HUMAN:IL11_HUMAN:IL6RB_MOUSE:INTERLEUKIN-6[160 aa]:Interleukin-6[169 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-11[165 aa]:Interleukin-6[157 aa]:Interleukin-6 receptor subunit beta[584 aa] 1 0 6 5 1 17 0 1 1 7 0 21 1 1 11 3 11 11 0 1 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 156 S S e 51.6 1n26_A IL6RB_HUMAN:IL27A_HUMAN:CLCF1_HUMAN:IL11_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-27 subunit alpha[191 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa]:Interleukin-6 receptor subunit beta[584 aa] 2 7 1 1 1 5 0 1 5 15 5 1 7 1 1 24 6 9 9 1 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 157 P S e 90.7 1n26_A CSH_SHEEP:IL6RB_HUMAN:PRL_HUMAN:CLCF1_HUMAN:IL6RB_MOUSE:PLACENTAL LACTOGEN[183 aa]:Interleukin-6 receptor beta chain[298 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:ADNECTIN[91 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[296 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[584 aa] NAG 10 0 13 26 0 9 0 1 7 1 0 5 4 1 1 7 6 2 0 5 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 158 A e 43.8 1n26_A IL6RB_HUMAN:PRL_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Prolactin[165 aa]:Prolactin[186 aa]:Nanobody 22E11[123 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[584 aa] CL GOL 23 4 1 2 0 22 0 1 10 1 0 6 1 3 3 14 5 3 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 159 E E e 57.3 1n26_A IL6RB_HUMAN:Interleukin-6 receptor subunit beta[296 aa] beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 1 0 13 34 1 3 0 1 11 3 2 1 1 6 11 3 4 4 0 1 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 160 D E e 32.7 1n26_A IL11_HUMAN:IL6_HUMAN:Interleukin-11[165 aa]:Interleukin-6[157 aa] 1 0 32 10 0 5 0 5 6 4 0 0 1 0 1 9 14 7 3 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 161 F E e 27.3 1n26_A 4 0 2 1 23 1 12 2 3 8 0 3 1 9 3 4 2 3 7 13 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 162 Q E e 59.7 1n26_A IL11_HUMAN:IL6_HUMAN:Interleukin-11[165 aa]:Interleukin-6[157 aa] CO3 4 0 1 3 1 3 0 12 3 1 2 3 8 23 18 6 7 4 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 163 E E e 26.6 1n26_A IL11_HUMAN:Interleukin-11[165 aa] 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. 2 0 6 26 1 1 9 1 14 2 0 6 1 1 4 8 1 6 5 6 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 164 P E e 64.3 1n26_A 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. 2 0 1 16 1 2 1 1 4 2 1 4 22 11 4 9 6 2 0 11 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 165 C E b 11.3 1n26_A 1 60 1 1 3 1 0 1 5 1 0 5 1 1 4 7 1 4 1 1 MUTAGEN:/note="C->L: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->L: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 166 Q E e 52.6 1n26_A 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. 1 3 3 19 4 1 0 1 25 1 0 2 19 14 4 1 1 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 167 Y E e 26.5 1n26_A antibody heavy chain[220 aa] 1 0 25 6 0 1 5 5 1 5 0 0 1 0 7 4 4 1 0 33 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 168 S E e 28.9 1n26_A NA 0 3 4 3 0 0 0 3 9 1 0 0 6 5 2 25 11 0 0 27 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 169 Q T e 78.1 1n26_A antibody heavy chain[220 aa] GOL 0 6 5 0 6 0 10 2 12 8 0 4 0 16 7 0 0 23 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 170 E T e 98.0 1n26_A antibody heavy chain[220 aa] NAG PGE 5 0 6 29 0 4 0 0 6 0 0 0 7 4 7 3 25 0 0 3 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 171 S T e 46.1 1n26_A antibody heavy chain[220 aa] 16 23 3 0 0 7 2 0 3 14 0 0 4 6 0 9 4 5 0 5 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 172 Q T e 32.1 1n26_A Nanobody 124C4[125 aa]:antibody heavy chain[220 aa] NA GOL:PGE 0 0 6 3 0 21 3 0 7 11 0 4 0 29 0 10 8 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 173 K E e 34.0 1n26_A antibody light chain[215 aa]:antibody heavy chain[220 aa] 0 4 7 23 0 3 0 0 10 3 0 0 25 0 8 15 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 174 F E b 1.9 1n26_A NA 1 0 6 1 14 13 5 1 1 15 0 24 1 1 1 1 11 1 0 3 MUTAGEN:/note="F->L: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="F->L: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 175 S E e 21.9 1n26_A I12A_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa] MNB NA GOL 1 0 1 1 2 10 0 1 7 1 0 0 1 0 8 63 2 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 176 C E b 0.0 1n26_A GOL 5 60 1 2 1 2 1 8 1 6 1 1 1 1 1 2 2 4 0 1 MUTAGEN:/note="C->A: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->A: Complete loss of ligand-binding.":DISULFID:ECO:0000269|PubMed:10066782":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 177 Q E e 44.9 1n26_A antibody heavy chain[220 aa] NA 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. GOL 5 1 10 4 4 2 12 1 2 2 7 8 1 9 1 2 9 7 0 12 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 178 L E b 1.1 1n26_A 2 3 1 2 17 2 1 20 2 16 4 1 1 1 4 2 2 18 0 1 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 179 A e 59.8 1n26_A I12A_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa] MNB:NAG GOL 22 3 6 5 1 6 6 1 1 1 0 5 8 1 5 11 16 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 180 V b 4.7 1n26_A I12A_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:antibody heavy chain[220 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-23 subunit alpha[138 aa]:Interleukin-11[164 aa] MNB NA GOL 2 26 1 1 1 7 1 9 17 2 1 1 1 1 3 2 1 12 0 11 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 181 P e 55.8 1n26_A I12A_HUMAN:IL6_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-6[163 aa]:Interleukin-12 subunit alpha[176 aa]:Nanobody 124C4[125 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa] 7 0 6 1 1 1 0 1 7 6 8 4 40 8 1 1 1 4 0 1 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 182 E T e 31.7 1n26_A I12A_HUMAN:IL6_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-6[163 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa] NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 15 0 5 21 1 1 14 1 3 11 0 2 1 1 1 3 11 1 0 7 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 183 G T e 63.1 1n26_A IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:Interleukin-6[163 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa] CYS NA 31 0 1 1 11 16 0 1 4 9 0 1 1 1 1 7 13 1 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 184 D b 5.6 1n26_A I12A_HUMAN:CSH_SHEEP:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] CYS 8 0 9 26 5 1 2 1 1 8 0 4 5 1 1 16 1 1 6 4 MUTAGEN:/note="D->T: 30% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="D->T: 30% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 185 S e 64.1 1n26_A CSH_SHEEP:Q98823_HHV8:IL6_HUMAN:LIF_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:PLACENTAL LACTOGEN[183 aa]:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] CYS IL6RB_HUMAN:PROTEIN (GP130)[215 aa] GOL 0 0 0 38 5 6 0 7 4 0 6 4 4 0 0 17 9 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 186 S b 2.3 1n26_A CSH_SHEEP:Q98823_HHV8:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:IL6_HUMAN:PLACENTAL LACTOGEN[183 aa]:VIRAL IL-6[167 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa] 4 0 0 6 0 0 0 0 5 0 0 0 4 0 3 34 36 7 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 187 F E e 46.9 1n26_A CSH_SHEEP:Q98823_HHV8:IL6RB_HUMAN:IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:IL6RB_MOUSE:PLACENTAL LACTOGEN[183 aa]:VIRAL IL-6[167 aa]:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:INTERLEUKIN-6[160 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa]:Interleukin-6 receptor subunit beta[584 aa] IL6RB_HUMAN:PROTEIN (GP130)[215 aa] 0 0 0 0 5 0 0 13 3 27 2 2 9 3 4 4 5 3 6 13 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 188 Y E b 0.9 1n26_A Q98823_HHV8:IL6_HUMAN:IL12A_HUMAN:LIF_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:IL6RB_HUMAN:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Interleukin-12 subunit alpha[176 aa]:ADNECTIN[91 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6[157 aa] 0 0 0 0 7 0 6 0 0 3 0 0 22 0 6 0 0 0 0 56 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 189 I E e 23.4 1n26_A Q98823_HHV8:IL6_HUMAN:LIF_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL6RB_HUMAN:IL11_HUMAN:IL6RB_MOUSE:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:INTERLEUKIN-6[160 aa]:Ciliary neurotrophic factor[174 aa]:H4H25311P2 antibody Fab fragment light chain[215 a..:H4H25311P2 antibody Fab fragment heavy chain[217 a..:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6[169 aa]:Interleukin-11[165 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-11[164 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6[157 aa]:Interleukin-6 receptor subunit beta[584 aa] beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. IL6RB_HUMAN:PROTEIN (GP130)[215 aa] CO3 0 0 0 5 7 0 0 48 14 0 0 7 0 0 3 0 6 11 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 190 V E b 0.0 1n26_A Q98823_HHV8:IL6_HUMAN:LIF_HUMAN:CNTF_HUMAN:IL11_HUMAN:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:Interleukin-6[169 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa] 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. CO3 5 0 0 18 0 0 0 22 0 5 2 6 0 0 0 0 3 37 0 0 MUTAGEN:/note="V->G: 80% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="V->G: 80% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 191 S E b 0.0 1n26_A IL6_HUMAN:LIF_HUMAN:CNTF_HUMAN:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Ciliary neurotrophic factor[174 aa]:H4H25311P2 antibody Fab fragment light chain[215 a..:H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. CO3 0 0 0 3 0 3 0 1 10 1 2 14 0 2 4 10 19 23 8 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 192 M E b 0.0 1n26_A alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. 0 0 0 0 0 0 0 11 0 21 5 0 0 0 0 0 6 57 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 193 C E b 6.0 1n26_A LIF_HUMAN:Leukemia inhibitory factor[169 aa]:H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 6 8 0 20 0 0 0 0 2 2 1 8 0 0 0 5 24 24 0 0 MUTAGEN:/note="C->D: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":DISULFID:ECO:0000269|PubMed:10066782":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->D: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":DISULFID:ECO:0000269|PubMed:10066782":TOPO_DOM:/note="Extracellular" 194 V E b 0.0 1n26_A NAG alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 44 0 11 11 0 0 0 0 0 0 5 0 0 0 0 0 0 28 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 195 A E b 3.6 1n26_A H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 28 0 0 15 0 0 0 11 6 0 0 6 0 0 0 4 20 9 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 196 S E b 0.0 1n26_A H4H25311P2 antibody Fab fragment heavy chain[217 a.. NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 5 0 0 0 0 0 4 6 0 0 0 63 6 0 0 2 0 14 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 197 S T b 10.9 1n26_A I12R1_HUMAN:DAPK1_HUMAN:Nanobody 22E11[123 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 19 0 4 5 0 0 20 0 0 6 0 0 7 14 5 20 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 198 V T e 24.0 1n26_A I12R1_HUMAN:DAPK1_HUMAN:Nanobody 22E11[123 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:Interleukin-12 receptor subunit beta-1,Death-assoc.. 2 0 0 0 0 6 5 5 20 36 9 0 0 0 0 0 0 12 4 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 199 G E e 22.6 1n26_A I12R1_HUMAN:DAPK1_HUMAN:Nanobody 22E11[123 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:H4H25311P2 antibody Fab fragment heavy chain[217 a..:Interleukin-12 receptor subunit beta-1,Death-assoc.. 6 0 0 0 2 69 0 0 5 18 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 200 S E e 28.1 1n26_A I12R1_HUMAN:DAPK1_HUMAN:Nanobody 22E11[123 aa]:Briakinumab FAb Heavy chain[205 aa]:Briakinumab FAb Heavy chain[208 aa]:Briakinumab FAb Heavy chain[206 aa]:Briakinumab FAb Heavy chain[207 aa]:Interleukin-12 receptor subunit beta-1[109 aa]:H4H25311P2 antibody Fab fragment light chain[215 a..:H4H25311P2 antibody Fab fragment heavy chain[217 a..:Interleukin-12 receptor subunit beta-1,Death-assoc.. beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 6 0 0 0 0 0 4 2 28 0 0 7 0 0 0 41 2 1 0 5 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 201 K E e 43.9 1n26_A IL6RB_HUMAN:H4H25311P2 antibody Fab fragment light chain[215 a..:Interleukin-6 receptor subunit beta[298 aa] NAG alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. SO4 10 0 0 0 0 0 0 0 12 0 0 11 0 2 2 24 9 9 0 21 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 202 F E e 40.7 1n26_A IL6RB_HUMAN:H4H25311P2 antibody Fab fragment light chain[215 a..:Interleukin-6 receptor subunit beta[298 aa] SO4 1 6 0 21 4 1 0 0 0 1 0 3 0 0 6 36 8 4 0 8 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 203 S b 0.0 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:H4H25311P2 antibody Fab fragment light chain[215 a..:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa] NAG alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. SO4 0 0 0 5 0 0 0 0 0 6 0 21 0 0 0 61 7 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 204 K e 78.8 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:H4H25311P2 antibody Fab fragment light chain[215 a..:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[583 aa] SO4 5 0 28 6 2 0 5 0 2 14 0 5 0 0 3 4 5 0 0 21 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 205 T e 32.5 1n26_A IL23R_HUMAN:IL6RB_HUMAN:IL11_HUMAN:IL6RB_MOUSE:Interleukin-23 receptor[293 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-11[164 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] NAG alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. CO3:SO4 0 0 6 2 4 0 3 7 0 3 0 5 34 0 0 4 22 5 0 5 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 206 Q E e 33.7 1n26_A 0 0 0 3 2 0 4 9 0 22 0 0 0 12 3 31 0 13 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 207 T E e 55.2 1n26_A CSH_SHEEP:IL6RB_HUMAN:LIF_HUMAN:PRL_HUMAN:CLCF1_HUMAN:IL6RB_MOUSE:PLACENTAL LACTOGEN[183 aa]:Interleukin-6 receptor beta chain[298 aa]:Leukemia inhibitory factor[169 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:ADNECTIN[91 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] 2 0 5 0 0 2 0 0 0 0 0 9 4 0 6 21 31 2 0 17 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 208 F E b 9.6 1n26_A ADNECTIN[91 aa] 0 0 0 0 66 0 0 3 0 11 0 0 0 0 0 0 0 20 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 209 Q E e 34.2 1n26_A CSH_SHEEP:IL6_HUMAN:LIF_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:ADNECTIN[91 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[164 aa]:Interleukin-6[157 aa] CYS 0 0 40 2 24 0 4 4 0 0 0 0 0 10 0 3 11 0 0 2 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 210 G T b 1.2 1n26_A 0 0 0 7 8 4 0 29 0 5 0 0 9 0 2 9 4 23 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 211 C T e 22.7 1n26_A I12A_HUMAN:CSH_SHEEP:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa] CYS NA 0 2 0 5 8 0 0 0 0 21 0 0 0 3 26 0 17 12 0 3 MUTAGEN:/note="C->A: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->A: No change of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 212 G T e 34.5 1n26_A CSH_SHEEP:IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL27A_HUMAN:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:ADNECTIN[91 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[144 aa] NA 3 0 48 0 0 5 4 0 5 1 0 0 0 0 0 7 5 0 0 19 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 213 I b 15.2 1n26_A IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] CO3 0 0 0 0 0 0 0 78 9 0 5 0 0 0 0 0 0 8 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 214 L B b 0.6 1n26_A IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] 0 0 0 0 0 0 0 30 0 13 0 0 0 0 0 0 0 57 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 215 Q e 29.1 1n26_A IL6RA_HUMAN:antibody heavy chain[220 aa]:IL6R-D2 peptide[10 aa] IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] CO3:GOL 0 0 0 9 0 0 0 4 45 0 0 0 0 20 17 0 5 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 216 P b 1.6 1n26_A GOL 0 0 0 0 0 0 0 0 0 0 0 0 93 0 0 0 7 0 0 0 DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 217 D e 32.1 1n26_A IL6RA_HUMAN:antibody light chain[215 aa]:antibody heavy chain[220 aa]:IL6R-D2 peptide[10 aa] IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] GOL 0 0 67 6 0 4 3 0 0 11 0 3 0 0 0 3 3 0 0 0 MUTAGEN:/note="D->V: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="D->V: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 1":TOPO_DOM:/note="Extracellular" 218 P e 31.8 1n26_A antibody light chain[215 aa]:antibody heavy chain[220 aa] GOL 0 0 0 0 0 0 0 0 0 0 0 0 96 0 0 4 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 219 P b 4.7 1n26_A 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 220 A E e 22.3 1n26_A Nanobody 124C4[125 aa]:antibody light chain[215 aa] NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL 10 0 0 14 0 0 6 0 24 2 0 0 5 9 2 0 2 13 11 3 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 221 N E e 67.3 1n26_A NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 16 2 0 13 0 0 3 0 0 64 0 0 0 3 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-93, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-245 and A-350.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:28060820":MUTAGEN:/note="N->A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-93, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-245 and A-350.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 222 I E b 17.5 1n26_A 0 0 0 0 0 0 0 15 0 66 0 0 0 0 0 0 0 19 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 223 T E e 42.2 1n26_A NAG 2 0 0 3 0 0 5 0 2 0 0 0 0 23 23 9 20 12 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 224 V E b 13.3 1n26_A 7 0 0 0 0 0 0 11 0 41 2 0 0 0 0 0 0 39 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 225 T E e 46.1 1n26_A IL6A_HUMAN:PRLR_RAT:IL-6 Receptor alpha chain[299 aa]:Prolactin receptor[202 aa] 0 0 0 17 0 0 0 3 34 0 0 5 0 0 9 17 15 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 226 A E e 40.2 1n26_A NA IL6A_HUMAN:CRLF1_HUMAN:IL-6 Receptor alpha chain[299 aa]:Cytokine receptor-like factor 1[303 aa] SO4 9 2 0 0 8 0 0 0 2 6 0 9 38 4 5 9 2 3 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 227 V e 26.7 1n26_A IL6RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[197 aa] NA IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 0 0 0 0 5 9 32 0 0 0 2 5 9 0 35 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 228 A T e 58.9 1n26_A IL6RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 8 0 3 10 1 7 6 1 9 1 3 11 22 3 4 8 1 1 0 3 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 229 R T e 82.6 1n26_A CNTFR_HUMAN:IL6RA_HUMAN:I11RA_HUMAN:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 15 0 2 13 0 21 0 0 21 0 0 3 9 0 6 7 0 2 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 230 N e 31.5 1n26_A CNTFR_HUMAN:IL6RA_HUMAN:I11RA_HUMAN:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 3 9 0 0 0 0 4 15 0 34 0 0 3 16 3 0 0 9 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 231 P T e 39.5 1n26_A NA PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[199 aa] 0 0 9 6 0 4 0 4 2 0 0 0 30 8 0 28 0 7 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 232 R T e 45.8 1n26_A IL6RB_HUMAN:I27RA_HUMAN:CNTFR_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-6 receptor subunit beta[392 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] 1 0 8 0 0 3 0 0 0 1 4 0 0 6 53 18 2 0 0 0 MUTAGEN:/note="R->S: 30% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="R->S: 30% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 233 W e 31.9 1n26_A IL6RB_HUMAN:CNTFR_HUMAN:IL6RA_HUMAN:I11RA_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit alpha[201 aa]:Interleukin-6 receptor subunit beta[584 aa] IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 0 0 0 6 9 0 0 0 0 0 25 24 0 3 0 12 17 MUTAGEN:/note="W->Q: 30% decrease of ligand-binding and increase of IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="W->Q: 30% decrease of ligand-binding and increase of IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 234 L E b 0.0 1n26_A 0 7 0 0 0 4 0 0 0 64 3 0 0 0 0 0 0 23 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 235 S E e 25.8 1n26_A IL6RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:VHH6[110 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-6 receptor subunit alpha[201 aa] PRLR_RAT:Prolactin receptor[202 aa] SO4 0 0 0 33 0 0 6 0 14 0 0 0 0 4 5 10 11 2 15 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 236 V E b 0.0 1n26_A 13 0 0 0 0 0 0 9 0 24 0 0 0 0 0 0 0 54 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 237 T E e 35.7 1n26_A VHH6[110 aa]:VHH6[124 aa] NAG SO4 3 0 0 0 0 0 0 0 15 2 0 0 0 10 5 45 17 0 0 2 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 238 W E b 3.6 1n26_A VHH6[110 aa]:VHH6[124 aa] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 239 Q E e 46.4 1n26_A Nanobody 124C4[125 aa]:VHH6[110 aa]:VHH6[124 aa] NAG SO4:GOL 0 0 0 37 2 0 0 0 0 3 0 0 0 16 7 13 12 11 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 240 D e 30.9 1n26_A VHH6[110 aa]:VHH6[124 aa] NAG SO4:GOL 0 0 17 0 0 0 2 0 0 0 0 9 24 0 0 8 5 0 0 35 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 241 P b 4.7 1n26_A NAG GOL 1 0 1 4 0 1 0 1 1 1 0 1 84 1 1 1 1 1 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 242 H T e 99.0 1n26_A Q98823_HHV8:PRL_HUMAN:VIRAL IL-6[167 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:antibody heavy chain[220 aa] NAG GOL 12 0 25 7 0 9 2 1 1 5 0 1 8 1 3 11 12 1 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 243 S T e 25.8 1n26_A CSH_SHEEP:PRL_HUMAN:IL6RA_HUMAN:PLACENTAL LACTOGEN[183 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:IL6R-D2 peptide[10 aa] NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] 6 0 12 0 0 1 0 3 3 5 2 0 0 4 0 37 26 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 244 W b 4.0 1n26_A CSH_SHEEP:PRL_HUMAN:IL6RA_HUMAN:PLACENTAL LACTOGEN[183 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:IL6R-D2 peptide[10 aa] IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] 8 0 1 1 1 7 0 1 1 8 0 1 1 1 1 1 2 10 55 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 245 N e 61.8 1n26_A CSH_SHEEP:PRL_HUMAN:IL27A_HUMAN:CLCF1_HUMAN:IL6RA_HUMAN:PLACENTAL LACTOGEN[183 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:Interleukin-27 subunit alpha[191 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:IL6R-D2 peptide[10 aa] NAG 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. IL6RA_HUMAN:Interleukin-6 receptor subunit alpha[14 aa] 1 0 21 1 5 1 0 1 13 7 0 5 1 1 14 27 1 1 0 0 SITE:/note="Not glycosylated":CARBOHYD:/note="N-linked (GlcNAc...) asparagine":MUTAGEN:/note="N->A: Slightly induces cleavage and sIL6R levels.No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-350.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":SITE:/note="Not glycosylated":CARBOHYD:/note="N-linked (GlcNAc...) asparagine":MUTAGEN:/note="N->A: Slightly induces cleavage and sIL6R levels.No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-350.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 246 S e 33.6 1n26_A I12A_HUMAN:CSH_SHEEP:PRL_HUMAN:IL12A_HUMAN:IL6_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Prolactin[165 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Nanobody 124C4[125 aa]:Interleukin-6[157 aa] 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. IL6RB_HUMAN:PROTEIN (GP130)[215 aa] SO4 5 0 9 1 0 4 0 1 4 1 0 0 17 3 6 17 30 1 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 247 S S e 71.9 1n26_A I12A_HUMAN:CSH_SHEEP:Q98823_HHV8:IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:VHH6[110 aa]:INTERLEUKIN-6[152 aa]:VHH6[124 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab light chain[212 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[215 aa]:Prolactin receptor[202 aa] 0 0 0 19 5 19 0 0 0 0 0 0 3 6 0 44 0 0 0 2 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 248 F S e 78.5 1n26_A I12A_HUMAN:CSH_SHEEP:Q98823_HHV8:IL6_HUMAN:LIF_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:VIRAL IL-6[167 aa]:Interleukin-6[163 aa]:Leukemia inhibitory factor[169 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Interleukin-12 subunit alpha[176 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:VHH6[124 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab light chain[212 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Interleukin-6[157 aa] NAG IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[215 aa]:Prolactin receptor[202 aa] 0 0 0 0 5 7 9 8 0 8 0 0 0 0 0 12 0 3 16 31 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 249 Y S e 20.4 1n26_A I12A_HUMAN:CSH_SHEEP:IL6_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:IL6RA_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Nanobody 124C4[125 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:IL6R-D2 peptide[10 aa]:Interleukin-6[157 aa] NAG PRLR_RAT:IL6RA_HUMAN:Prolactin receptor[202 aa]:Interleukin-6 receptor subunit alpha[14 aa] 0 0 0 0 60 0 0 6 0 18 0 4 0 0 0 0 0 0 0 9 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 250 R e 43.9 1n26_A I12A_HUMAN:CSH_SHEEP:IL6RA_HUMAN:IL6_HUMAN:PRL_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Interleukin-6 receptor alpha chain[201 aa]:Interleukin-6[163 aa]:Prolactin[186 aa]:INTERLEUKIN-6[160 aa]:VHH6[110 aa]:INTERLEUKIN-6[152 aa]:VHH6[124 aa]:Switch Ab Fab light chain[212 aa]:Switch Ab Fab heavy chain[209 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Soluble interleukin-6 receptor subunit alpha[296 a..:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Interleukin-6 receptor subunit alpha[201 aa]:Interleukin-6[157 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[215 aa]:Prolactin receptor[199 aa] 0 0 3 0 0 0 4 5 0 13 2 0 7 5 8 32 11 11 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 251 L E b 1.1 1n26_A Heavy chain of Tocilizumab Fab[211 aa] 5 0 0 0 0 0 0 4 0 85 2 0 0 0 0 0 0 4 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 252 R E e 33.2 1n26_A CSH_SHEEP:PRL_HUMAN:PLACENTAL LACTOGEN[183 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Peptide 23-652[15 aa]:Switch Ab Fab heavy chain[209 aa]:Light chain of Sarilumab Fab[212 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Light chain of Tocilizumab Fab[209 aa] IL6RB_HUMAN:PROTEIN (GP130)[208 aa] 0 0 2 2 0 0 4 3 40 12 2 0 0 14 2 0 19 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 253 F E b 0.0 1n26_A Light chain of Sarilumab Fab[212 aa] 0 0 0 0 51 0 0 0 0 0 0 11 0 0 0 6 0 0 0 33 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 254 E E b 15.6 1n26_A Light chain of Tocilizumab Fab[209 aa] MNB IL6RB_HUMAN:PROTEIN (GP130)[208 aa] 0 12 6 27 10 3 3 0 0 2 0 3 0 11 15 4 0 0 4 0 MUTAGEN:/note="E->A: 50% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="E->A: 50% decrease of ligand-binding and IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 255 L E b 0.0 1n26_A 0 0 0 0 0 0 0 33 0 45 0 0 0 0 0 0 0 23 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 256 R E e 22.9 1n26_A ADNECTIN[91 aa] MNB PO4 0 0 0 0 0 0 0 0 0 0 0 0 0 43 57 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 257 Y E b 3.5 1n26_A IL6RB_HUMAN:I27RA_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] MAN 2 0 0 0 0 0 0 2 0 15 0 0 0 0 0 0 2 25 0 54 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 258 R E b 18.6 1n26_A ADNECTIN[91 aa] 0 0 0 0 0 0 3 0 23 0 0 0 0 22 50 0 0 0 0 3 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 259 A E b 3.6 1n26_A I27RA_HUMAN:Interleukin-27 receptor subunit alpha[195 aa] 4 0 0 4 0 17 0 0 0 3 0 0 48 0 10 0 9 5 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 260 E T e 43.2 1n26_A CRLF1_HUMAN:Cytokine receptor-like factor 1[303 aa] 9 0 0 30 0 0 0 2 35 9 0 0 0 4 0 2 0 7 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 261 R T e 66.0 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] 0 0 17 10 0 4 1 5 16 0 0 17 0 9 7 4 2 0 5 3 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 262 S e 45.3 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] 25 0 2 8 0 0 9 0 19 5 0 3 0 0 0 25 1 0 0 2 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 263 K S e 91.0 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[584 aa] 11 0 5 13 0 0 0 0 19 3 0 0 9 0 22 9 7 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 264 T e 68.8 1n26_A IL6RB_HUMAN:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[398 aa] 9 0 5 27 0 1 0 3 6 8 0 0 0 5 7 12 14 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 265 F e 26.8 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:ADNECTIN[91 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[584 aa] SO4 1 0 3 3 19 3 0 0 12 3 0 0 0 0 2 3 0 0 48 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 266 T E e 39.6 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] SO4 0 0 3 21 0 0 4 6 13 0 0 13 0 5 0 12 14 5 3 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 267 T E e 43.5 1n26_A IL6RB_HUMAN:Nanobody 37D5[125 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[208 aa]:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[199 aa] SO4 0 0 20 5 0 0 5 3 0 4 11 0 0 11 4 5 27 5 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 268 W E e 33.9 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:ADNECTIN[91 aa]:Nanobody 37D5[122 aa]:Nanobody 37D5[125 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Light chain of Tocilizumab Fab[209 aa]:Interleukin-6 receptor subunit beta[584 aa] MNB PO4 1 0 1 1 4 1 9 8 4 8 0 3 1 6 8 1 1 27 17 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 269 M E e 42.0 1n26_A IL6RB_MOUSE:Light chain of Sarilumab Fab[212 aa]:Light chain of Tocilizumab Fab[209 aa]:Interleukin-6 receptor subunit beta[584 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[208 aa]:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa] 1 0 1 10 14 1 5 4 6 12 9 11 14 3 1 3 4 2 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 270 V b 3.3 1n26_A I27RA_HUMAN:Nanobody 37D5[125 aa]:Peptide 23-652[15 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Light chain of Tocilizumab Fab[209 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[208 aa]:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa] 16 2 4 0 6 0 3 2 0 16 0 0 6 0 0 6 2 38 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 271 K G e 63.2 1n26_A IL6RB_HUMAN:I27RA_HUMAN:IL6RA_HUMAN:I11RA_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Peptide 23-652[15 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-6 receptor subunit beta[589 aa]:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Light chain of Tocilizumab Fab[209 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa]:Interleukin-6 receptor subunit beta[584 aa] IL6RB_HUMAN:PRLR_RAT:PROTEIN (GP130)[208 aa]:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] 12 0 8 15 0 11 2 0 5 2 2 0 4 7 0 5 14 12 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 272 D G e 80.2 1n26_A IL6RA_HUMAN:IL23A_HUMAN:I27RA_HUMAN:CNTFR_HUMAN:CNTF_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[141 aa]:Peptide 23-652[15 aa]:Switch Ab Fab light chain[212 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Ciliary neurotrophic factor[174 aa]:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] PRLR_RAT:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] 0 0 31 5 2 10 0 0 15 0 0 8 10 7 0 0 6 5 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 273 L G b 16.9 1n26_A IL6_HUMAN:I27RA_HUMAN:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Switch Ab Fab light chain[212 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa] NAG SO4 16 0 1 2 0 6 0 11 7 12 0 6 1 5 1 5 17 10 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 274 Q e 36.2 1n26_A IL6RA_HUMAN:IL27A_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:VHH6[110 aa]:VHH6[124 aa]:Interleukin-27 subunit alpha[191 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] PRLR_RAT:Prolactin receptor[202 aa] SO4 4 0 0 7 0 8 0 0 13 0 0 0 0 31 9 10 18 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 275 H S e 27.2 1n26_A CSH_SHEEP:CNTFR_HUMAN:I11RA_HUMAN:PLACENTAL LACTOGEN[183 aa]:VHH6[110 aa]:VHH6[124 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Heavy chain of Tocilizumab Fab[211 aa] PRLR_RAT:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] SO4 9 5 0 3 0 11 9 0 7 6 0 3 3 0 0 15 25 0 0 2 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 276 H E e 42.4 1n26_A IL6RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:VHH6[110 aa]:VHH6[124 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-11 receptor subunit alpha[197 aa] PRLR_RAT:Prolactin receptor[202 aa] SO4 10 0 0 8 0 3 16 0 4 0 3 0 0 18 7 17 7 4 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 277 C E b 11.3 1n26_A IL6RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] SO4 4 19 1 7 17 1 7 3 7 6 0 1 1 1 1 5 14 1 0 6 MUTAGEN:/note="C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 278 V E e 27.3 1n26_A IL6RA_HUMAN:I27RA_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:Interleukin-6 receptor alpha chain[201 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit alpha[201 aa] PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] SO4 0 4 11 0 4 0 0 5 20 2 0 3 0 0 8 0 17 25 0 0 MUTAGEN:/note="V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 279 I E b 0.0 1n26_A PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa] 0 3 0 0 0 0 4 51 0 16 2 0 0 0 0 2 6 14 0 0 MUTAGEN:/note="I->D: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="I->D: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" I->N:LP/P:rs1689606: Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5) ; 280 H S e 51.3 1n26_A IL6RA_HUMAN:IL6RB_HUMAN:CNTFR_HUMAN:I11RA_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor alpha chain[201 aa]:Interleukin-6 receptor beta chain[298 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Soluble interleukin-6 receptor subunit alpha[296 a..:Interleukin-11 receptor subunit alpha[200 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-11 receptor subunit alpha[294 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-11 receptor subunit alpha[283 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-11 receptor subunit alpha[197 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit alpha[201 aa]:Interleukin-6 receptor subunit beta[584 aa] PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] 5 6 0 0 11 0 9 0 10 13 0 4 0 9 6 3 16 5 0 0 MUTAGEN:/note="H->I: No change of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="H->I: No change of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" H->P:US:-: Hyper-IgE syndrome 5, autosomal recessive, with recurrent infections (HIES5) ; 281 D S e 39.5 1n26_A IL6RB_HUMAN:I27RA_HUMAN:CNTFR_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-27 receptor subunit alpha[195 aa]:Ciliary neurotrophic factor receptor subunit alpha..:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa]:Prolactin receptor[202 aa] 0 3 55 0 0 6 5 0 3 0 0 3 0 0 11 11 3 0 0 0 MUTAGEN:/note="D->G: 70% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="D->G: 70% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 282 A b 0.0 1n26_A I27RA_HUMAN:IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] PRLR_RAT:Prolactin receptor[181 aa] 36 3 0 0 0 3 0 0 6 45 0 0 0 0 0 3 2 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 283 W e 57.8 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor beta chain[298 aa]:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[589 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] PRLR_RAT:PROLACTIN RECEPTOR[169 aa]:Prolactin receptor[181 aa]:Prolactin receptor[199 aa] 1 0 5 1 1 1 2 1 25 6 0 9 1 3 7 1 1 14 5 17 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 284 S T e 53.9 1n26_A I27RA_HUMAN:IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-27 receptor subunit alpha[195 aa]:Interleukin-27 receptor subunit alpha[191 aa]:Interleukin-6 receptor subunit beta[297 aa]:Interleukin-6 receptor subunit beta[398 aa]:Interleukin-6 receptor subunit beta[298 aa]:Interleukin-6 receptor subunit beta[583 aa]:Interleukin-6 receptor subunit beta[584 aa] 26 2 1 1 1 5 0 1 3 1 0 1 38 1 10 8 1 1 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 285 G T e 45.2 1n26_A MAN 1 0 1 1 20 56 0 1 4 1 0 1 1 2 7 3 1 1 0 0 MUTAGEN:/note="G->D: 80% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="G->D: 80% decrease of ligand-binding and no IL6 signaling.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 286 L e 25.3 1n26_A IL6RB_HUMAN:IL6RB_MOUSE:Interleukin-6 receptor subunit beta[392 aa]:Interleukin-6 receptor subunit beta[583 aa] 8 0 1 1 2 4 0 5 12 12 7 1 1 11 1 1 26 6 0 1 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 287 R e 54.2 1n26_A MAN IL6A_HUMAN:CRLF1_HUMAN:IL-6 Receptor alpha chain[299 aa]:Cytokine receptor-like factor 1[303 aa] 1 0 1 28 1 1 0 1 21 2 0 2 9 1 18 1 4 6 0 1 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 288 H E b 1.0 1n26_A MAN PRLR_RAT:Prolactin receptor[181 aa] 6 0 1 1 1 2 18 1 1 2 0 1 1 1 1 2 1 1 0 57 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 289 V E b 4.0 1n26_A 9 0 1 16 6 1 0 10 1 14 0 6 1 0 1 5 1 23 0 5 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 290 V E b 0.0 1n26_A 0 0 0 0 20 0 0 18 0 1 0 0 0 0 0 0 0 57 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 291 Q E b 11.2 1n26_A SO4 0 0 0 2 0 0 0 0 0 0 0 0 0 57 31 6 0 0 0 0 MUTAGEN:/note="Q->K: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="Q->K: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 292 L E b 0.0 1n26_A 0 0 0 0 0 0 0 24 0 4 0 0 0 0 0 0 2 69 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 293 R E e 26.1 1n26_A ADNECTIN[91 aa]:Nanobody 37D5[122 aa]:Nanobody 37D5[125 aa]:Light chain of Tocilizumab Fab[209 aa] MNB IL6RB_HUMAN:PROTEIN (GP130)[208 aa] SO4:PO4 12 0 0 0 0 0 2 0 0 0 0 0 0 17 50 19 0 0 0 0 MUTAGEN:/note="R->G: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="R->G: Complete loss of ligand-binding.":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 294 A E b 0.0 1n26_A 51 28 0 0 0 5 0 0 0 0 0 0 0 0 0 16 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 295 Q E b 15.8 1n26_A I12A_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:ADNECTIN[91 aa]:Peptide 23-652[15 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Light chain of Tocilizumab Fab[209 aa] SO4 0 0 0 0 0 0 0 6 38 0 5 5 0 17 26 0 2 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 296 E E b 0.5 1n26_A I12A_HUMAN:IL6_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-6[163 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Peptide 23-652[15 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa] IL6RB_HUMAN:PROTEIN (GP130)[215 aa] 1 0 47 10 0 1 0 0 10 9 0 0 18 0 0 1 1 1 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 297 E T b 15.1 1n26_A I12A_HUMAN:CSH_SHEEP:IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL27A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Peptide 23-652[15 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Interleukin-6[157 aa] IL6RB_HUMAN:PROTEIN (GP130)[215 aa] 0 0 19 16 9 0 16 0 0 5 0 8 6 0 21 0 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 298 F T e 75.1 1n26_A I12A_HUMAN:IL6_HUMAN:IL23A_HUMAN:IL12A_HUMAN:IL27A_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-6[163 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Peptide 23-652[15 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Light chain of Sarilumab Fab[212 aa]:Heavy chain of Sarilumab Fab[207 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Light chain of Tocilizumab Fab[209 aa]:Interleukin-6[157 aa] ATP IL6RB_HUMAN:PROTEIN (GP130)[208 aa] 2 0 4 1 13 2 3 1 1 28 0 4 1 1 1 4 6 1 0 27 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 299 G T e 58.3 1n26_A I12A_HUMAN:IL23A_HUMAN:IL12A_HUMAN:CNTF_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Interleukin-12 subunit alpha[176 aa]:Interleukin-23 subunit alpha[141 aa]:ADNECTIN[91 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Peptide 23-652[15 aa]:Interleukin-23 subunit alpha[138 aa]:Ciliary neurotrophic factor[174 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-11[165 aa]:Interleukin-11[164 aa]:Light chain of Sarilumab Fab[212 aa]:Heavy chain of Sarilumab Fab[207 aa]:Light chain of Tocilizumab Fab[209 aa] 1 0 25 6 1 20 0 1 1 1 0 1 1 3 1 5 1 1 0 31 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 300 Q B b 19.4 1n26_A I12A_HUMAN:CSH_SHEEP:IL6_HUMAN:PRL_HUMAN:IL23A_HUMAN:IL27A_HUMAN:CLCF1_HUMAN:IL11_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:PLACENTAL LACTOGEN[183 aa]:Interleukin-6[163 aa]:Prolactin[165 aa]:Interleukin-23 subunit p19[133 aa]:Interleukin-23 subunit p19[161 aa]:Interleukin-23 subunit p19[159 aa]:Interleukin-23 subunit alpha[137 aa]:Prolactin[185 aa]:Prolactin[186 aa]:Interleukin-23 subunit alpha[141 aa]:ADNECTIN[91 aa]:Interleukin-23 subunit alpha[130 aa]:Interleukin-23 subunit alpha[129 aa]:INTERLEUKIN-6[160 aa]:INTERLEUKIN-6[152 aa]:Interleukin-23 subunit alpha[155 aa]:Interleukin-23 subunit alpha[162 aa]:Interleukin-23 subunit alpha[140 aa]:Interleukin-23 subunit alpha[144 aa]:Interleukin-23 subunit alpha[146 aa]:Interleukin-23 subunit alpha[139 aa]:Interleukin-23 subunit alpha[132 aa]:Peptide 23-652[15 aa]:Interleukin-23 subunit alpha[147 aa]:Switch Ab Fab heavy chain[209 aa]:Interleukin-27 subunit alpha[191 aa]:Interleukin-23 subunit alpha[138 aa]:Cardiotrophin-like cytokine factor 1[178 aa]:Interleukin-6[169 aa]:Interleukin-27 subunit alpha[177 aa]:Interleukin-11[165 aa]:Heavy chain of Tocilizumab Fab[211 aa]:Light chain of Tocilizumab Fab[209 aa]:Interleukin-6[157 aa] IL6RB_HUMAN:PROTEIN (GP130)[208 aa] 14 0 0 0 0 4 18 10 16 2 0 9 4 2 0 17 0 0 0 4 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 301 G S b 16.7 1n26_A I12A_HUMAN:INTERLEUKIN-12 ALPHA CHAIN[133 aa]:ADNECTIN[91 aa]:Peptide 23-652[15 aa] 0 0 0 0 0 74 0 0 0 0 0 0 0 0 0 26 0 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 302 E e 60.3 1n26_A ADNECTIN[91 aa] CL 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL:CO3:SO4 0 0 0 11 11 0 0 5 0 2 0 0 0 5 2 31 16 0 0 17 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 303 W b 19.1 1n26_A ADNECTIN[91 aa]:Nanobody 37D5[122 aa]:Peptide 23-652[15 aa]:Light chain of Sarilumab Fab[212 aa]:Light chain of Tocilizumab Fab[209 aa] MNB IOD:CL IL6RB_HUMAN:PROTEIN (GP130)[208 aa] SO4:CO3 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 96 0 MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 304 S b 2.3 1n26_A GOL 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 98 0 0 0 0 MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 305 E e 62.8 1n26_A GOL 8 0 29 47 0 0 0 0 2 0 0 5 0 0 5 0 3 1 0 0 MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 306 W e 20.3 1n26_A ADNECTIN[91 aa] MNB 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 307 S b 0.0 1n26_A 23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 75 2 0 0 0 MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":MOTIF:/note="WSXWS motif":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 308 P e 82.9 1n26_A antibody light chain[215 aa] 1 0 0 14 0 0 0 0 0 11 0 0 45 7 0 7 0 12 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 309 E e 58.3 1n26_A NAG 12 0 0 73 0 0 0 0 0 0 0 0 7 0 0 0 8 0 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 310 A E b 13.4 1n26_A NAG CRLF1_HUMAN:Cytokine receptor-like factor 1[303 aa] 58 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 0 17 0 0 DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 311 M E e 36.7 1n26_A NAG IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 10 0 0 0 8 0 14 0 0 8 4 0 0 0 0 17 22 0 16 0 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 312 G E b 16.7 1n26_A IL6A_HUMAN:CRLF1_HUMAN:IL-6 Receptor alpha chain[299 aa]:Cytokine receptor-like factor 1[303 aa] 25 0 0 0 0 55 0 0 0 0 0 0 0 0 9 11 0 0 0 0 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 313 T e 37.7 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 88 0 0 0 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 314 P b 2.3 1n26_A 0 0 0 0 0 0 0 0 0 0 0 0 70 10 0 0 20 0 0 0 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 315 W e 30.3 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 1 0 1 1 0 1 0 1 1 1 0 0 1 0 13 20 1 1 38 20 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 316 T e 49.4 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 5 0 0 20 0 0 0 5 0 0 0 0 0 0 0 13 57 0 0 0 COMPBIAS:/note="Polar residues":DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:DOMAIN:/note="Fibronectin type-III 2":TOPO_DOM:/note="Extracellular" 317 E e 81.9 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 0 0 21 53 0 16 0 0 0 0 0 0 11 0 0 0 0 0 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 318 S e 137.5 1n26_A IL6A_HUMAN:IL-6 Receptor alpha chain[299 aa] 1 0 1 13 0 1 0 1 1 1 0 0 14 0 24 32 10 1 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 319 R S b 17.0 3l5h_A 1 0 1 13 0 1 0 1 27 1 0 0 24 0 28 1 1 1 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 320 S e 39.3 3l5h_A 18 0 1 23 0 16 0 1 1 1 0 0 1 0 1 23 14 1 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 321 P b 6.2 3l5h_A 1 0 1 1 0 1 0 10 1 1 0 0 52 0 9 8 14 1 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 322 P e 29.5 8qy6_F 0 0 0 0 0 0 0 18 0 0 0 0 82 0 0 0 0 0 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 323 A 61 0 0 0 0 23 0 0 0 16 0 0 0 0 0 0 0 0 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 324 E 2 0 1 25 1 2 0 1 1 2 23 1 1 17 1 2 1 1 16 1 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 325 N 0 0 16 0 0 38 0 0 0 23 0 11 0 0 0 0 12 0 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 326 E 0 0 0 39 0 0 0 22 0 0 0 23 0 16 0 0 0 0 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 327 V 0 0 0 0 0 0 0 16 0 39 0 0 11 0 0 0 0 34 0 0 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 328 S 1 0 1 1 1 12 16 1 1 1 0 1 13 1 1 13 1 1 34 1 COMPBIAS:/note="Polar residues":TOPO_DOM:/note="Extracellular":COMPBIAS:/note="Polar residues":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 329 T 1 0 1 1 1 1 0 1 1 13 0 23 1 1 1 1 28 1 0 23 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 330 P 1 0 1 1 1 1 0 1 1 1 23 1 50 1 1 13 1 1 0 1 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 331 M 1 0 17 1 1 1 0 1 1 1 12 1 1 1 23 1 35 1 0 1 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 332 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 84 0 0 0 0 16 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 333 A 23 0 0 0 0 0 23 0 0 0 0 0 16 0 0 16 0 22 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 334 L 0 0 0 16 0 0 0 23 0 11 0 0 12 16 0 22 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 335 T 0 0 23 0 0 16 0 0 0 0 0 0 0 0 0 0 23 38 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 336 T 0 0 0 38 0 0 16 0 0 0 0 0 0 0 0 0 23 0 0 23 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 337 N 0 0 22 0 0 16 0 0 0 0 0 46 16 0 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 338 K 0 0 0 12 0 0 0 0 11 0 0 0 0 32 23 11 0 0 0 11 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 339 D 11 0 34 0 0 0 0 0 0 0 0 0 0 39 0 0 0 16 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 340 D 0 0 39 0 0 0 0 0 0 16 0 22 0 23 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 341 D 0 0 11 28 0 0 22 23 0 0 0 0 0 0 0 16 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 342 N 16 0 12 22 0 0 0 0 0 0 0 11 16 0 0 23 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 343 I 16 0 22 0 0 0 0 23 0 23 0 0 0 0 0 0 0 16 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 344 L 0 0 0 0 23 0 0 0 0 11 0 0 16 22 0 12 0 16 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 345 F 16 0 0 0 11 0 0 0 0 0 0 0 16 0 0 12 0 0 23 22 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 346 R 0 0 0 11 0 11 0 0 34 0 0 0 0 16 27 0 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 347 D 0 0 11 28 0 0 0 0 0 0 0 23 16 0 0 22 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 348 S 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 79 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 349 A 30 0 0 0 0 0 0 0 0 21 0 0 0 0 0 21 28 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 350 N 0 0 0 28 0 0 0 0 0 0 0 30 21 21 0 0 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine":MUTAGEN:/note="N->A: No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-245. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-245.":TOPO_DOM:/note="Extracellular":CARBOHYD:/note="N-linked (GlcNAc...) asparagine":MUTAGEN:/note="N->A: No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-245. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-245.":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 351 A 79 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 352 T 0 0 0 0 0 0 21 0 0 0 0 0 21 0 0 0 58 0 0 0 CARBOHYD:/note="O-linked (GlcNAc) threonine":MUTAGEN:/note="T->A: No effect on IL6R signaling.":TOPO_DOM:/note="Extracellular":CARBOHYD:/note="O-linked (GlcNAc) threonine":MUTAGEN:/note="T->A: No effect on IL6R signaling.":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 353 S 21 0 0 0 0 0 0 0 0 0 0 0 21 0 0 58 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 354 L 0 0 0 0 0 0 0 0 0 30 0 0 0 0 42 0 0 28 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" 355 P 0 0 0 0 0 0 0 0 0 21 0 0 79 0 0 0 0 0 0 0 MUTAGEN:/note="P->I,D: Reduces cleavage by ADAM17.":SITE:/note="Cleavage; by ADAM10 and ADAM17":MUTAGEN:/note="PV->IE: Abolishes cleavage by ADAM17.":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="P->I,D: Reduces cleavage by ADAM17.":SITE:/note="Cleavage; by ADAM10 and ADAM17":MUTAGEN:/note="PV->IE: Abolishes cleavage by ADAM17.":TOPO_DOM:/note="Extracellular" 356 V 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 21 0 58 0 0 MUTAGEN:/note="V->E,G: Abolishes cleavage by ADAM17.":SITE:/note="Cleavage; by ADAM10 and ADAM17":MUTAGEN:/note="PV->IE: Abolishes cleavage by ADAM17.":TOPO_DOM:/note="Extracellular":MUTAGEN:/note="V->E,G: Abolishes cleavage by ADAM17.":DISORDER:predicted by DISOPRED:SITE:/note="Cleavage; by ADAM10 and ADAM17":MUTAGEN:/note="PV->IE: Abolishes cleavage by ADAM17.":TOPO_DOM:/note="Extracellular" 357 Q 0 0 21 0 0 0 0 0 0 21 0 0 0 58 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 358 D 0 0 30 14 0 14 21 0 0 0 0 0 0 21 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Extracellular" D->A:LB/B:rs2228145: -; 359 S 0 0 0 0 0 0 0 0 0 0 0 0 21 0 21 58 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 360 S 15 0 42 0 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 361 S 0 0 0 0 0 0 0 0 0 0 0 0 35 0 0 65 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 362 V 0 0 0 0 0 0 0 14 0 0 14 0 0 0 21 0 0 51 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 363 P 0 0 0 21 0 0 0 0 0 0 0 0 65 0 0 14 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 364 L 0 0 0 0 0 0 0 0 0 79 0 0 0 21 0 0 0 0 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 365 P 0 0 0 0 0 0 0 0 0 0 0 0 79 0 0 0 0 21 0 0 TOPO_DOM:/note="Extracellular":TOPO_DOM:/note="Extracellular" 366 T 21 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 58 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 367 F 0 0 0 21 58 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 368 L 0 0 0 0 0 0 0 0 0 79 0 0 0 21 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 369 V 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 370 A 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 371 G 0 0 0 0 0 58 0 0 0 21 0 0 0 0 0 0 0 21 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 372 G 21 0 0 0 0 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 373 S 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 79 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 374 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 375 A 58 0 0 0 0 21 0 0 0 0 0 0 0 0 0 21 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 376 F 0 0 0 0 79 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 377 G 0 0 0 0 21 58 0 0 0 21 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 378 T 0 0 0 0 0 21 0 0 0 28 0 0 0 0 0 21 30 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 379 L 0 21 0 0 0 0 0 0 0 79 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 380 L 0 0 0 0 0 0 0 0 0 79 0 0 0 0 0 0 0 21 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 381 C 21 58 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 382 I 0 0 0 0 0 21 0 30 0 21 0 0 0 0 0 0 0 28 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 383 A 57 0 0 0 28 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 384 I 0 0 0 0 0 0 0 58 0 21 0 0 0 0 0 0 0 21 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 385 V 21 0 0 0 0 21 0 43 0 0 0 0 0 0 0 0 0 15 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" V->I:LB/B:rs2228146: -; 386 L 21 0 0 0 0 0 0 0 0 79 0 0 0 0 0 0 0 0 0 0 TRANSMEM:/note="Helical":TRANSMEM:/note="Helical" 387 R 0 0 0 0 0 21 0 0 0 21 0 0 0 0 58 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 388 F 21 0 0 0 30 0 0 0 0 49 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 389 K 2 0 1 1 1 2 0 1 59 23 0 1 1 1 1 2 1 1 0 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 390 K 2 0 1 1 1 22 0 1 45 2 0 1 1 15 1 2 1 1 0 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 391 T 2 0 1 1 1 2 0 1 29 23 0 1 1 1 1 2 31 1 0 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 392 W 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 85 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 393 K 3 1 2 3 2 3 1 2 45 4 1 2 2 17 2 3 2 3 1 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 394 L 0 0 0 0 0 0 0 0 0 72 0 0 0 0 0 28 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 395 R 0 0 0 14 0 0 0 0 0 0 0 0 0 29 57 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 396 A 58 0 0 0 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 397 L 0 0 0 28 0 0 0 0 0 30 0 0 0 0 42 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 398 K 0 0 0 0 0 0 0 0 58 0 0 0 0 0 42 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 399 E 0 0 0 58 0 21 0 0 0 0 0 0 0 0 0 21 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 400 G 0 0 0 0 0 72 0 0 0 0 0 0 0 0 0 28 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 401 K 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 402 T 0 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 58 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 403 S 0 0 0 0 0 42 0 0 0 0 0 15 0 0 0 15 28 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 404 M 0 0 0 0 0 0 0 0 0 0 30 0 35 0 0 35 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 405 H 0 0 0 0 0 0 30 0 0 0 0 0 49 21 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 406 P 0 0 0 0 0 0 0 0 42 0 0 0 58 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 407 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 408 Y 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 58 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 409 S 0 0 0 0 21 0 0 0 0 21 0 0 14 0 0 44 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 410 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 411 G 42 0 0 0 0 58 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 412 Q 0 0 0 0 0 0 0 0 0 0 0 0 49 30 0 21 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 413 L 0 0 0 0 0 0 0 0 0 58 21 0 0 0 0 0 0 21 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 414 V 2 1 2 2 1 2 1 44 2 3 1 1 1 1 1 2 2 32 0 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 415 P 2 1 2 2 1 2 1 1 2 3 1 1 73 1 1 2 2 2 0 1 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 416 E 4 1 3 55 2 4 1 2 3 4 1 2 3 2 2 3 3 3 1 2 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 417 R 4 1 3 3 2 4 1 2 3 4 1 2 3 2 54 3 3 3 1 2 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 418 P 4 1 3 3 2 4 1 2 3 4 1 2 54 2 2 3 3 3 1 2 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 419 R 0 0 0 0 0 0 0 0 74 0 0 0 0 0 26 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":TOPO_DOM:/note="Cytoplasmic" 420 P 0 0 0 0 0 0 0 0 0 0 0 0 74 0 0 26 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 421 T 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 422 P 0 0 0 0 48 0 0 0 0 0 0 0 52 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 423 V 0 0 0 0 0 0 0 0 0 48 0 0 0 0 0 0 0 52 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 424 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 425 V 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 426 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 427 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 428 I 0 0 0 0 0 0 0 52 0 48 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 429 S 2 0 1 2 1 2 1 1 1 2 1 1 1 1 1 53 25 2 0 1 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 430 P 2 0 1 2 1 2 1 1 1 2 1 1 77 1 1 2 1 2 0 1 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 431 P 2 0 1 2 1 2 1 1 1 2 1 1 53 1 1 26 1 2 0 1 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 432 V 2 0 1 2 1 26 1 1 1 2 1 1 1 1 1 2 1 53 0 1 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 433 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 76 24 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 434 P 0 0 0 0 0 0 24 0 0 0 0 0 76 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 435 S 0 0 0 0 0 0 24 0 0 0 0 50 0 0 0 26 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 436 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 437 L 0 0 0 0 0 0 0 0 0 52 0 0 0 0 0 48 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 438 G 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 439 S 2 0 1 2 1 2 1 1 1 2 1 1 1 1 1 52 26 2 0 1 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 440 D 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 441 N 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 442 T 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 443 S 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 52 0 24 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 444 S 0 0 0 0 0 0 0 0 0 0 0 24 0 0 26 50 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 445 H 0 0 0 0 0 0 74 0 0 0 0 26 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 446 N 0 0 0 0 0 0 0 0 0 0 0 26 0 0 0 74 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 447 R 0 48 0 0 0 0 0 0 0 0 0 0 0 0 52 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 448 P 0 0 0 0 0 0 0 0 0 48 0 0 52 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 449 D 0 0 26 26 0 48 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 450 A 52 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 48 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 451 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 452 D 0 0 74 0 0 26 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 453 P 24 0 0 0 0 0 0 0 0 0 0 0 76 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 454 R 0 0 0 0 0 0 0 0 0 0 0 0 0 74 26 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 455 S 0 24 0 0 0 0 0 0 0 0 0 0 0 0 0 76 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 456 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 457 Y 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 76 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 458 D 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 459 I 0 0 0 0 0 0 0 26 0 0 0 48 0 0 0 0 0 26 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 460 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 461 N 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 462 T 0 0 0 0 0 0 0 0 0 0 0 0 0 0 74 0 26 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 463 D 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 464 Y 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 465 F 0 0 0 0 52 0 0 0 0 48 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 466 F 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 467 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic" 468 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 TOPO_DOM:/note="Cytoplasmic":DISORDER:predicted by DISOPRED:TOPO_DOM:/note="Cytoplasmic"