site aa pred_sec pred_expbur pred_accessibility pdb_asym_id hetero nucleotide compound metal otherpoly homo precipitant A C D E F G H I K L M N P Q R S T V W Y feature_table variant 1 M 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 2 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 3 R 0 0 0 0 0 0 34 0 0 0 0 0 0 0 66 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 4 Y 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 0 0 33 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 5 G 0 0 0 0 0 66 0 0 0 0 0 0 0 0 34 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 6 A 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 7 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 8 L 0 0 0 0 0 0 0 0 0 33 0 0 33 0 0 34 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 9 R 0 0 0 0 0 67 0 0 0 0 0 0 0 0 33 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 10 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 11 S 0 0 34 0 0 33 0 0 0 0 0 0 0 0 0 33 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 12 C 0 33 0 0 0 0 34 0 0 33 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 13 P 0 0 0 0 0 0 0 0 0 34 0 0 66 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 14 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 15 S 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 16 G 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 17 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66 0 0 0 34 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 18 E 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 19 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 20 G 33 0 0 0 0 33 0 0 0 0 0 0 0 0 34 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 21 Q 0 0 0 0 0 0 0 0 0 34 0 0 0 33 0 33 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 22 D 0 0 66 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 23 G 0 0 0 0 0 33 0 0 0 0 0 0 0 0 67 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 24 T 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 67 33 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 25 A 33 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 26 G 0 0 0 0 0 66 0 0 0 0 0 0 34 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 27 A 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 28 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 29 G 3 1 2 2 1 69 1 2 2 3 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 30 L 3 1 2 2 1 2 1 2 2 70 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 31 L 3 1 2 2 1 2 1 2 2 70 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 32 W 3 1 2 2 1 2 1 2 2 3 1 1 2 1 2 2 2 2 67 1 SIGNAL::SIGNAL: 33 M 3 1 2 2 1 2 1 2 2 3 68 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 34 G 5 1 4 4 3 38 1 3 4 6 2 3 3 3 3 5 4 4 1 2 SIGNAL::SIGNAL: 35 L 2 21 1 1 1 2 0 38 1 23 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 36 V 2 0 1 1 1 2 0 38 1 23 0 1 1 1 1 2 1 22 0 1 SIGNAL::SIGNAL: V->A:LB/B:rs1050228: -; 37 L 2 0 1 1 1 2 0 1 1 60 0 1 1 1 22 2 1 1 0 1 SIGNAL::SIGNAL: 38 A 22 0 1 1 1 39 0 1 1 23 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 39 L 2 0 1 1 1 2 0 38 1 44 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 40 A 21 0 0 0 0 58 0 0 0 0 0 0 0 0 0 0 0 0 21 0 SIGNAL::SIGNAL: 41 L 0 0 0 0 0 0 0 37 0 63 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 42 A 21 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 0 37 0 0 SIGNAL::SIGNAL: 43 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 44 A 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 45 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 46 A 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 58 0 0 SIGNAL::SIGNAL: 47 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 37 0 0 0 0 48 A 63 0 0 0 0 0 0 0 0 0 0 37 0 0 0 0 0 0 0 0 49 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 37 0 0 50 S 3 1 2 2 23 3 1 2 2 3 1 2 23 2 2 23 2 2 0 1 51 D 0 0 42 37 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 D->V:US:rs7485899: Niemann-Pick disease B (NPDB) ; 52 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 53 R 0 0 0 0 0 37 0 0 0 0 0 0 21 0 21 0 21 0 0 0 54 V 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 55 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 56 W 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 0 63 0 57 A 21 0 0 0 0 0 0 0 37 0 0 0 0 0 0 21 0 21 0 0 58 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 59 A 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 60 E 0 0 37 42 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 61 A 63 0 0 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 H 0 0 0 0 0 0 58 0 0 0 0 0 0 0 21 0 0 0 0 21 63 P 0 0 0 37 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 64 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 37 65 S 0 0 0 0 0 0 0 0 0 0 0 37 42 0 0 21 0 0 0 0 66 P 37 0 0 0 0 0 0 0 0 0 0 0 21 0 0 21 21 0 0 0 67 Q 0 0 0 21 0 0 0 0 0 0 0 0 0 42 37 0 0 0 0 0 68 G 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 69 H 0 0 0 0 0 0 63 0 0 0 0 37 0 0 0 0 0 0 0 0 70 P 0 0 0 37 0 0 0 0 0 0 0 0 42 0 0 21 0 0 0 0 71 A 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 72 R 0 0 0 0 0 0 0 0 79 0 0 0 0 0 21 0 0 0 0 0 73 L 0 0 0 0 42 0 0 0 0 21 37 0 0 0 0 0 0 0 0 0 74 H 0 0 0 0 0 0 21 21 0 37 0 0 0 0 0 21 0 0 0 0 75 R 21 0 0 0 0 0 0 0 0 0 0 0 0 0 79 0 0 0 0 0 76 I 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 0 37 77 V 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 78 P 0 0 0 0 0 0 0 0 37 0 0 0 63 0 0 0 0 0 0 0 79 R 0 0 0 0 0 0 0 0 37 0 0 0 21 21 21 0 0 0 0 0 80 L 37 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 81 R 0 0 0 0 0 0 0 37 0 0 0 0 0 42 21 0 0 0 0 0 82 D 0 0 43 15 0 0 0 0 0 0 0 27 0 0 0 15 0 0 0 0 83 V 31 0 0 27 0 0 0 0 28 0 0 0 0 0 0 0 0 15 0 0 84 F e 114.4 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 46 0 0 0 0 0 0 0 27 0 0 0 0 0 0 28 85 G e 78.6 5jg8_B NAG 0 0 0 27 0 73 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 W G e 78.1 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 28 0 0 0 0 0 0 27 0 0 0 0 0 0 46 0 87 G G e 54.8 5jg8_B 0 0 0 0 0 15 0 0 0 0 0 0 0 43 27 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 88 N G e 73.3 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 0 0 0 0 27 0 0 46 28 0 0 0 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":DOMAIN:/note="Saposin B-type":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":DOMAIN:/note="Saposin B-type" 89 L T e 55.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 0 0 80 20 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 90 T H e 30.5 5jg8_B 2 0 1 1 1 2 0 1 1 2 0 1 1 1 1 44 37 1 0 1 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 91 C H e 20.7 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->H:LP/P:-: Niemann-Pick disease B (NPDB) ; 92 P H e 56.6 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 31 15 0 0 0 15 0 14 0 0 25 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 93 I H e 62.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 9 0 0 15 14 0 0 23 0 0 0 0 0 0 0 15 8 16 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 94 C H b 10.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->W:LP/P:-: Niemann-Pick disease B (NPDB) ; 95 K H e 41.0 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 0 55 0 0 0 0 16 0 0 29 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 96 G H e 48.8 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 29 32 0 16 0 0 0 0 0 0 0 15 0 9 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 97 L H e 57.3 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 14 0 0 0 0 31 0 15 0 40 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 98 F H b 15.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 16 0 0 0 25 0 0 30 0 0 0 0 0 0 0 0 0 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 99 T H e 43.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 29 0 0 0 0 0 0 0 0 15 0 0 0 31 25 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 100 A H e 61.6 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 25 0 0 0 0 14 0 0 0 31 0 0 0 15 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 101 I H e 41.5 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 15 0 0 0 0 0 0 17 0 40 0 0 0 0 0 0 0 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 102 N H b 16.4 5jg8_B 0 0 8 16 0 0 0 0 0 0 0 17 0 44 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 103 L H e 50.6 5jg8_B 14 0 16 0 38 0 9 0 15 8 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 104 G H e 34.5 5jg8_B 6E0 0 0 0 15 31 25 0 0 0 14 15 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 105 L H b 16.3 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 0 0 0 45 0 40 0 0 0 0 0 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7512695: Niemann-Pick disease A (NPDA) ;L->P:LP/P:rs7512695: Niemann-Pick disease B (NPDB) ; 106 K T e 58.5 5jg8_B 29 0 0 0 0 15 0 0 48 0 0 0 0 0 8 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 107 K S e 54.7 5jg8_B SO4 0 0 0 15 15 0 0 0 33 0 0 8 0 14 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 108 E H e 61.3 5jg8_B 0 0 15 17 0 0 0 0 30 0 0 30 0 8 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 109 P H e 60.5 5jg8_B 24 0 0 0 0 0 0 0 15 0 0 0 17 15 0 14 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 110 N H e 34.5 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] PO4:SO4 0 0 0 0 0 15 0 0 0 0 0 17 0 0 0 39 29 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 111 V H b 6.0 5jg8_B 0 0 14 30 0 0 0 15 0 16 0 0 0 0 0 0 0 25 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 112 A H e 44.6 5jg8_B 25 0 0 30 0 0 0 0 0 0 0 14 15 0 0 0 16 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 113 R H e 58.5 5jg8_B PO4 0 15 15 30 0 0 0 0 0 0 0 0 0 0 17 0 0 15 8 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 114 V H e 44.0 5jg8_B 6E0 ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 0 0 40 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 115 G H b 3.6 5jg8_B 14 0 0 0 0 25 0 16 0 15 15 0 0 0 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 116 S H e 44.5 5jg8_B 14 0 0 30 0 0 0 0 31 0 0 0 0 0 0 25 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 117 V H e 54.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] SO4 0 0 0 0 29 16 0 15 0 0 0 0 0 0 0 0 0 25 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 118 A H e 36.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 70 0 0 0 0 0 0 0 0 30 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 119 I H b 10.5 5jg8_B 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 16 15 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 120 K H e 70.8 5jg8_B SO4 0 0 31 0 15 0 0 15 25 0 0 14 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 121 L H e 52.8 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 24 0 61 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 122 C H e 25.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 123 N H e 40.6 5jg8_B 0 0 14 15 0 0 0 16 24 0 0 8 0 0 0 0 15 8 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 124 L H e 69.7 5jg8_B 16 0 0 0 0 0 0 0 0 45 9 0 0 0 0 0 15 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 125 L H e 74.7 5jg8_B 0 0 0 0 44 0 0 0 0 40 0 0 0 0 0 16 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 126 K e 70.3 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(.. 15 0 14 0 0 0 30 0 33 0 0 9 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 127 I e 89.5 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 16 0 0 0 55 15 0 0 0 0 0 0 0 0 14 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 128 A S b 19.6 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(.. 25 0 0 60 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 129 P e 34.1 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(.. 0 0 15 0 0 0 0 0 15 0 0 0 40 30 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 130 P H e 64.3 5jg8_B 15 0 0 0 0 0 0 0 0 9 0 15 46 0 0 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 131 A H e 59.8 5jg8_B 32 0 24 31 0 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 132 V H b 10.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" V->A:LP/P:-: Niemann-Pick disease B (NPDB) ; 133 C H b 2.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 134 Q H e 52.0 5jg8_B SO4 0 0 15 0 0 0 0 0 14 0 0 30 0 25 0 0 16 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 135 S H e 36.7 5jg8_B SO4 0 0 0 0 15 46 0 0 0 0 0 14 0 0 0 25 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 136 I H e 25.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 17 0 0 0 0 0 0 68 0 15 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 137 V H b 13.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa] 0 0 0 0 0 0 0 44 0 16 0 0 0 0 0 15 0 25 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 138 H H e 48.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. SO4 0 0 0 0 0 0 17 0 0 0 0 16 15 8 0 30 0 0 0 14 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 139 L H e 24.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 14 0 15 0 0 0 0 0 0 40 0 16 0 15 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7970447: Niemann-Pick disease B (NPDB) ; 140 F H b 19.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 141 E H b 15.1 5jg8_B 15 0 0 25 0 0 0 0 14 0 0 0 0 0 15 15 0 16 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 142 D H e 40.7 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. SO4 0 0 69 0 0 0 0 0 0 0 0 15 16 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 143 D H b 18.5 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 25 44 0 0 0 16 0 0 15 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 144 M H e 24.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 30 0 0 16 0 0 17 0 0 0 0 0 15 22 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 145 V H b 16.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 15 0 0 0 0 0 15 0 0 0 0 0 0 55 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 146 E H e 20.1 5jg8_B 0 0 16 25 14 0 0 0 0 0 0 15 0 0 0 0 0 0 0 30 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 147 V H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 148 W H e 47.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 15 0 0 15 0 45 0 0 0 0 0 0 0 0 25 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 149 R H b 9.9 5jg8_B 0 0 0 14 0 0 0 16 15 0 0 0 0 0 23 15 17 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 150 R H e 36.0 5jg8_B SO4 0 0 0 0 0 0 0 0 0 0 0 0 0 31 54 0 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 151 S T b 2.3 5jg8_B 15 0 0 0 0 0 0 15 0 0 0 0 15 0 0 55 0 0 0 0 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD.":DOMAIN:/note="Saposin B-type":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD.":DOMAIN:/note="Saposin B-type" 152 V T b 19.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 16 0 0 0 0 0 0 15 0 15 0 0 0 0 15 39 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 153 L S e 22.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 15 30 0 0 0 0 25 0 0 0 0 0 0 0 30 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 154 S S e 21.9 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 40 60 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 155 P T e 27.1 5jg8_B 0 0 0 0 0 15 0 0 0 0 0 0 85 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 156 S T b 18.0 5jg8_B alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. 0 0 0 29 0 0 15 0 0 0 0 0 0 0 0 56 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 157 E T b 8.5 5jg8_B 0 0 0 39 0 0 0 0 0 0 0 0 0 46 0 0 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 158 A H b 7.1 5jg8_B 25 0 0 0 0 0 0 29 0 31 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 159 C H b 0.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->R:LP/P:rs7275041: Niemann-Pick disease B (NPDB) ; 160 G H b 9.5 5jg8_B SO4 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 161 L H e 56.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] SO4 14 0 0 0 15 0 0 15 0 40 0 0 0 0 0 0 0 0 0 16 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 162 L H e 64.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] SO4 0 0 0 0 30 0 0 15 0 40 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 163 L T e 46.1 5jg8_B SO4 1 0 1 1 1 1 0 31 1 42 15 1 1 1 1 1 1 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7801344: Niemann-Pick disease B (NPDB) ; 164 G B b 17.9 5jg8_B SO4 15 16 1 1 1 26 0 1 16 1 0 1 16 1 1 1 1 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 165 S T e 89.8 5jg8_B 0 0 15 0 0 15 0 0 0 0 0 29 0 0 0 41 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 166 T T e 92.9 5jg8_B 17 15 16 1 16 1 0 1 1 1 0 1 1 1 1 18 9 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 167 C B b 1.3 5jg8_B 15 69 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 168 G b 17.9 5jg8_B 0 0 15 0 0 70 0 0 0 0 0 0 15 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" G->R:LP/P:rs1847910: Niemann-Pick disease B (NPDB) ; 169 H e 68.6 5jg8_B 0 0 15 0 0 0 39 0 0 0 0 0 15 0 0 16 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 170 W e 37.8 5jg8_B 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 30 15 15 25 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 171 D e 35.8 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 54 0 0 0 0 0 0 0 0 16 15 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 172 I T b 12.9 5jg8_B 0 0 0 16 0 0 0 25 0 29 0 0 0 0 15 15 0 0 0 0 173 F T e 46.4 5jg8_B 15 0 0 15 25 0 0 0 0 0 0 15 0 0 0 0 14 0 0 16 174 S e 34.4 5jg8_B SO4 0 0 0 0 0 0 14 0 0 0 0 0 0 0 16 55 15 0 0 0 175 S e 70.3 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. SO4 0 0 0 0 0 15 0 15 0 0 14 0 0 16 0 32 9 0 0 0 176 W b 9.6 5jg8_B NAG 1 0 1 17 1 1 0 1 1 1 0 1 1 1 1 1 1 1 69 0 177 N e 74.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 0 0 0 0 0 0 0 0 0 0 15 69 0 0 0 16 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." 178 I b 5.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 0 0 0 0 13 0 0 45 0 15 13 0 0 0 0 0 0 13 0 0 I->N:LP/P:rs7497807: Niemann-Pick disease B (NPDB) ; 179 S e 60.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 11 0 0 0 0 13 0 10 0 0 0 12 0 0 0 33 21 0 0 0 180 L e 22.5 5jg8_B 0 0 0 0 0 0 0 21 12 57 0 10 0 0 0 0 0 0 0 0 181 P e 34.9 5jg8_B SO4 0 0 0 0 10 15 0 0 0 0 0 0 75 0 0 0 0 0 0 0 182 T S e 94.2 5jg8_B 6 0 0 0 0 21 0 0 0 15 0 0 21 0 0 6 17 13 0 0 183 V S e 38.0 5jg8_B SO4 15 0 1 1 1 2 0 1 22 2 12 1 1 1 1 1 16 19 0 1 184 P e 84.5 5jg8_B SO4 0 0 0 0 0 9 0 0 10 0 0 10 70 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 185 K e 35.8 5jg8_B SO4 12 0 0 0 0 0 0 0 67 0 0 11 0 10 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 186 P e 34.1 5jg8_B 0 0 0 0 0 12 0 0 0 0 0 0 67 11 10 0 0 0 0 0 DISORDER:predicted by DISOPRED P->L:LP/P:rs1057517: Niemann-Pick disease A (NPDA) ; 187 P e 86.0 5jg8_B 0 0 0 0 0 12 0 0 12 0 0 0 56 10 0 0 10 0 0 0 DISORDER:predicted by DISOPRED 188 P e 60.5 5jg8_B 0 0 0 0 10 0 9 9 0 12 0 0 16 0 12 10 0 11 0 10 DISORDER:predicted by DISOPRED 189 K e 59.4 5jg8_B SO4 0 0 0 0 0 0 0 0 63 0 0 12 0 6 0 0 0 19 0 0 DISORDER:predicted by DISOPRED 190 P e 64.3 5jg8_B 0 0 10 0 0 0 0 21 10 0 0 0 59 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 191 P e 44.2 5jg8_B 0 0 0 0 0 0 0 0 18 16 0 0 38 0 0 0 10 10 8 0 DISORDER:predicted by DISOPRED 192 S e 65.6 5jg8_B SO4 7 0 10 0 0 0 0 0 16 11 0 0 9 9 0 19 0 17 0 0 DISORDER:predicted by DISOPRED 193 P e 90.7 5jg8_B 19 0 0 0 0 11 0 10 9 0 0 9 21 9 0 0 0 9 0 0 DISORDER:predicted by DISOPRED 194 P e 39.5 5jg8_B 7 0 0 0 0 20 0 8 9 0 0 0 38 9 0 0 0 9 0 0 DISORDER:predicted by DISOPRED 195 A e 58.0 5jg8_B 27 0 9 8 0 14 0 0 8 0 0 0 15 0 0 17 0 0 0 0 DISORDER:predicted by DISOPRED 196 P T e 104.7 5jg8_B 0 0 12 9 0 0 0 5 19 0 0 0 44 0 0 0 6 0 0 5 DISORDER:predicted by DISOPRED 197 G T e 106.0 5jg8_B 0 0 0 8 0 51 0 0 0 0 0 28 0 8 4 0 0 0 0 0 198 A e 25.0 5jg8_B 25 0 8 0 0 0 0 0 25 0 8 8 6 0 0 11 0 9 0 0 A->P:LP/P:rs7970447: Niemann-Pick disease B (NPDB) ; 199 P e 51.2 5jg8_B 6 0 0 0 0 0 0 0 0 9 0 0 51 8 0 23 0 0 0 0 200 V E e 48.7 5jg8_B GOL:PO4 0 0 0 0 0 0 8 16 0 8 8 0 0 0 0 0 21 36 0 0 201 S E b 1.6 5jg8_B GOL:PO4 0 0 0 0 7 48 0 0 8 8 6 0 0 0 0 20 0 0 0 0 202 R E b 19.0 5jg8_B GOL:PO4 0 0 0 0 0 0 0 0 18 0 0 0 0 21 55 0 0 0 0 6 R->C:LP/P:rs7495952: Niemann-Pick disease B (NPDB) ; 203 I E b 1.2 5jg8_B 7 0 0 0 61 0 0 15 0 0 0 0 0 0 0 0 0 18 0 0 204 L E b 0.0 5jg8_B GOL 0 0 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 22 0 205 F E b 0.5 5jg8_B 0 0 0 0 10 0 78 0 0 0 0 0 0 12 0 0 0 0 0 0 206 L E b 1.1 5jg8_B 0 0 0 0 0 0 0 61 0 26 0 0 0 0 0 0 0 14 0 0 207 T b 1.9 5jg8_B 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 76 0 0 0 208 D b 0.0 5jg8_B C5P:AP2:NT8:PC ZN MLI:PO4:ACT 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 209 L b 3.9 5jg8_B 0 0 0 0 4 0 0 20 0 45 20 0 0 0 0 0 5 5 0 0 210 H b 0.0 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:PO4:ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 211 W B b 6.8 5jg8_B CL 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 0 0 5 0 0 5 0 22 0 0 36 0 0 0 0 16 9 5 W->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 212 D b 3.1 5jg8_B 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 213 H S e 42.4 5jg8_B NAG CL 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. GOL 0 0 0 4 11 0 14 7 5 5 6 0 43 6 0 0 0 0 0 0 214 D e 25.9 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 16 9 12 0 0 0 0 5 5 4 0 5 0 0 14 5 0 25 215 Y B b 5.7 5jg8_B CL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 216 L e 24.7 5jg8_B CL 1 0 1 12 0 1 4 6 31 10 0 0 1 0 0 1 11 20 0 0 L->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 217 E T e 39.7 5jg8_B CL 4 0 0 29 0 0 10 4 7 0 0 0 6 0 0 5 5 25 0 6 218 G T e 41.7 5jg8_B 0 0 0 0 0 61 6 10 0 0 0 5 6 0 0 9 4 0 0 0 219 T S b 3.9 5jg8_B 5 0 0 0 0 10 0 0 9 6 5 0 0 0 0 34 33 0 0 0 220 D b 8.6 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 1 0 42 18 1 1 0 1 1 1 0 11 1 1 1 17 1 1 0 0 221 P S b 4.7 5jg8_B 24 1 2 7 1 2 1 11 2 3 1 1 24 1 1 2 8 7 0 1 222 D S e 46.9 5jg8_B 7 0 41 1 5 6 0 1 1 6 0 15 1 1 1 1 1 1 0 9 223 C b 13.3 5jg8_B 0 36 5 7 0 6 7 0 6 0 0 0 0 9 3 14 7 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 224 A S e 63.4 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 19 0 6 4 1 17 0 10 1 1 0 1 1 6 1 1 16 16 0 0 225 D S e 24.7 5jg8_B 2 9 34 6 1 1 5 1 11 2 0 4 1 1 6 1 7 1 0 6 MUTAGEN:/note="D->A: Does not affect cleavage by CASP7.":MUTAGEN:/note="D->A: Does not affect cleavage by CASP7." 226 P S e 34.9 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa] 12 1 1 2 1 2 7 1 2 2 1 5 41 1 1 2 6 11 0 1 227 L S b 0.0 5jg8_B 3 10 2 2 1 3 1 2 6 22 6 2 2 7 2 2 2 17 0 8 L->M:LP/P:-: Niemann-Pick disease B (NPDB) ;L->P:LP/P:rs7643179: Niemann-Pick disease B (NPDB) ; 228 C b 0.0 5jg8_B 17 52 1 1 1 1 0 1 1 6 0 1 1 1 1 1 6 5 0 1 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:rs1564923: Niemann-Pick disease A (NPDA) ; 229 C S b 0.0 5jg8_B GOL 1 67 1 1 1 1 0 1 1 2 0 1 1 1 1 11 1 1 0 7 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 230 R B b 2.4 5jg8_B SO4 5 0 8 1 1 1 21 1 1 2 0 1 1 1 42 11 1 1 0 1 R->C:LP/P:rs9896392: Niemann-Pick disease A (NPDA) ;R->C:LP/P:rs9896392: Niemann-Pick disease B (NPDB) ;R->H:LP/P:rs1413877: Niemann-Pick disease A (NPDA) ; 231 R T e 65.2 5jg8_B C5P GOL:SO4 6 0 12 7 1 7 7 1 11 2 0 1 7 1 21 10 1 7 0 1 232 G T e 92.9 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. SO4 0 0 8 0 0 37 9 0 0 0 0 7 5 6 0 18 0 5 0 5 233 S S b 10.9 5jg8_B SO4 18 0 6 0 0 0 0 0 20 0 0 5 5 0 0 25 10 11 0 0 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD.":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." 234 G e 54.8 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. SO4 6 0 7 0 0 57 0 0 0 0 6 10 0 0 0 6 0 0 0 6 G->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 235 L e 78.7 5jg8_B SO4 8 1 9 12 1 3 1 2 12 6 1 8 5 2 7 11 2 6 4 1 236 P e 20.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 6 0 7 2 1 2 1 1 1 2 1 1 39 10 1 7 8 8 0 1 237 P e 63.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 7 1 1 12 1 7 1 1 12 2 1 1 25 1 1 11 11 2 0 1 238 A T e 98.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 23 0 1 1 1 2 0 7 10 8 0 14 1 1 1 7 1 15 0 6 239 S T e 90.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL 2 0 11 7 1 22 0 1 6 11 0 1 1 1 1 24 1 7 0 1 240 R e 32.4 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 2 0 5 12 1 6 0 1 38 2 0 11 1 7 9 1 1 1 0 1 241 P e 76.7 5jg8_B 1 0 17 1 1 6 0 1 13 1 0 6 38 1 1 7 1 1 0 4 242 G e 33.3 5jg8_B 15 0 4 0 0 34 0 0 15 0 0 4 0 0 8 5 7 5 0 0 243 A b 8.0 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 67 0 4 0 0 5 0 0 0 0 0 7 11 0 0 0 0 5 0 0 A->V:LP/P:rs1291958: Niemann-Pick disease A (NPDA) ; 244 G b 13.1 5jg8_B 12 0 1 1 0 64 0 1 1 1 0 1 5 0 1 5 1 6 0 0 G->R:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 245 Y T e 50.0 5jg8_B 1 0 1 5 3 1 0 1 12 8 0 1 23 0 9 5 1 4 0 25 246 W T b 16.3 5jg8_B SO4 0 0 0 0 27 5 0 9 0 9 0 0 0 0 0 0 0 0 38 11 W->C:LP/P:-: Niemann-Pick disease B (NPDB) ; 247 G b 0.0 5jg8_B 5 0 0 0 0 95 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->S:LP/P:rs5877794: Niemann-Pick disease A (NPDA) ;G->S:LP/P:rs5877794: Niemann-Pick disease B (NPDB) ;G->D:LP/P:rs1590739: Niemann-Pick disease A (NPDA) ; 248 E b 18.6 5jg8_B 0 0 23 13 0 0 13 0 4 0 5 12 6 0 7 11 4 0 0 0 E->Q:LP/P:rs2007634: Niemann-Pick disease B (NPDB) ;E->K:LP/P:rs2007634: Niemann-Pick disease A (NPDA) ; 249 Y S b 13.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 5 0 1 1 0 6 0 0 1 5 12 0 5 0 0 1 1 26 0 36 250 S S e 29.7 5jg8_B GOL 2 1 2 2 1 24 1 2 2 3 5 1 2 1 2 31 2 8 0 11 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD.":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." S->R:LP/P:rs7507798: Niemann-Pick disease A (NPDA) ;S->R:LP/P:rs7507798: Niemann-Pick disease B (NPDB) ; 251 K S e 25.5 5jg8_B GOL 1 0 10 6 0 13 0 1 22 30 3 0 1 0 1 10 1 1 0 0 252 C b 0.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 253 D b 0.0 5jg8_B 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 MUTAGEN:/note="D->A: Abolished cleavage by CASP7.":SITE:/note="Cleavage; by CASP7":MUTAGEN:/note="D->A: Abolished cleavage by CASP7.":SITE:/note="Cleavage; by CASP7" D->E:LP/P:-: Niemann-Pick disease A (NPDA) ;D->H:LP/P:rs3981234: Niemann-Pick disease A (NPDA) ; 254 L B b 0.0 5jg8_B 4 4 0 0 0 8 0 14 0 18 0 0 0 0 0 35 17 0 0 0 SITE:/note="Cleavage; by CASP7":SITE:/note="Cleavage; by CASP7" 255 P b 4.7 5jg8_B 0 0 0 0 0 0 0 5 0 0 0 11 79 0 0 5 0 0 0 0 P->S:LP/P:-: Niemann-Pick disease A (NPDA) ; 256 L H e 35.4 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 5 0 20 0 0 4 0 8 20 0 0 7 0 0 0 4 7 25 257 R H e 20.2 5jg8_B CL 13 0 4 5 0 0 0 4 9 10 0 0 0 13 11 13 0 4 10 4 258 T H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 64 4 0 0 0 0 0 32 0 0 0 T->I:LP/P:-: Niemann-Pick disease B (NPDB) ; 259 L H b 1.7 5jg8_B 0 0 0 0 5 0 0 24 0 34 19 0 0 0 0 0 0 18 0 0 260 E H e 54.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 7 39 3 0 0 0 0 8 0 25 0 5 0 7 5 0 0 0 261 S H b 14.8 5jg8_B SO4 9 0 4 11 0 0 0 4 0 5 3 10 0 0 0 40 0 0 9 4 262 L H b 2.2 5jg8_B 16 0 0 0 0 0 0 9 0 13 14 0 0 0 0 12 29 7 0 0 263 L H b 5.6 5jg8_B 0 0 0 0 35 0 4 10 5 40 5 0 0 0 0 0 0 0 0 0 264 S H e 63.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 4 0 28 14 0 0 0 0 15 0 0 0 0 10 4 17 0 0 0 7 265 G T e 34.5 5jg8_B 7 0 0 7 15 8 20 0 0 0 0 9 0 0 0 0 0 0 29 5 266 L T b 7.3 5jg8_B GOL 0 0 0 0 0 0 0 47 0 21 19 0 0 5 0 0 0 8 0 0 267 G S e 66.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL 20 0 17 0 0 8 0 0 31 7 0 5 0 0 0 5 0 5 0 0 268 P S e 78.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 6 0 6 20 0 0 0 0 18 0 0 19 8 8 0 6 10 0 0 0 269 A S e 32.1 5jg8_B 17 0 0 0 0 4 5 7 12 0 0 8 0 0 4 15 15 12 0 0 270 G b 10.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 34 16 0 30 5 0 5 0 0 11 0 0 0 0 0 0 0 0 271 P e 82.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL 0 0 14 29 0 5 0 0 16 0 5 0 15 8 0 7 0 0 0 0 272 F b 12.4 5jg8_B GOL 8 0 0 4 8 0 0 43 8 15 0 7 0 0 0 0 0 7 0 0 273 D S e 45.1 5jg8_B GOL:SO4 0 0 86 3 0 0 0 0 0 0 0 0 0 0 0 11 0 0 0 0 274 M E b 4.8 5jg8_B 0 0 0 0 73 0 0 4 0 0 13 0 0 0 0 0 0 0 0 10 275 V E b 0.0 5jg8_B 0 0 0 0 0 0 0 47 0 0 11 0 0 0 0 0 0 42 0 0 276 Y E b 0.0 5jg8_B 0 0 0 0 4 0 0 50 0 13 5 0 0 0 0 0 0 21 0 8 277 W E b 0.8 5jg8_B 0 0 0 0 0 0 0 5 0 0 5 0 0 0 0 0 0 5 78 7 278 T b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 95 0 0 0 279 G b 2.4 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 280 D b 0.6 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:PO4:ACT 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" D->A:LP/P:-: Niemann-Pick disease A (NPDA) ; 281 I b 1.2 5jg8_B 0 0 12 0 5 7 0 8 0 5 0 42 0 0 0 11 5 0 0 5 282 P B b 3.1 5jg8_B 21 0 0 5 0 0 0 13 0 0 0 0 33 0 0 5 7 17 0 0 P->F:LP/P:-: Niemann-Pick disease B (NPDB) ; 283 A b 3.6 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 12 0 0 0 0 7 0 0 0 0 0 5 32 0 38 5 0 0 0 0 A->T:LP/P:rs7521485: Niemann-Pick disease B (NPDB) ; 284 H S b 11.0 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:GOL:PO4:ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 285 D b 9.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 52 0 0 7 0 0 0 5 0 8 0 0 0 0 5 24 0 0 286 V b 17.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SCN:GOL 0 0 5 0 0 5 0 15 0 7 0 13 13 0 8 10 3 21 0 0 287 W S b 9.6 5jg8_B 0 0 22 0 0 0 0 0 4 4 0 8 3 0 3 0 0 6 38 11 288 H S e 40.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 5 0 5 32 0 0 11 0 0 3 0 5 14 5 8 11 0 0 0 0 289 Q b 3.1 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 0 13 0 5 5 0 4 6 4 0 4 21 19 4 0 0 0 15 290 T e 39.0 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. GOL:SO4 0 0 0 0 5 0 0 4 0 22 0 4 0 0 4 28 27 5 0 0 291 R H e 27.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. GOL:SO4 4 0 0 19 0 7 0 5 0 0 0 5 20 12 8 6 10 0 0 4 R->H:US:rs1803161: Niemann-Pick disease B (NPDB) ; 292 Q H e 78.6 5jg8_B GOL:SO4 5 0 12 27 0 6 0 0 0 1 0 0 0 20 15 4 6 0 0 0 293 D H e 24.1 5jg8_B CL GOL 12 0 22 9 0 1 0 0 0 5 0 9 0 9 0 7 23 0 0 0 294 Q H b 4.6 5jg8_B 13 0 0 0 0 1 10 15 4 1 0 0 5 31 0 0 8 11 0 0 Q->K:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 295 L H e 27.5 5jg8_B 1 0 6 5 19 1 0 17 5 22 0 0 0 0 5 11 0 7 0 0 296 R H e 33.2 5jg8_B CL 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 1 0 8 21 10 4 0 3 3 9 0 7 0 10 11 6 0 0 0 5 R->Q:LB/B:rs3582445: -; 297 A H b 5.4 5jg8_B CL 21 0 4 5 0 1 0 14 0 1 16 8 0 0 0 5 0 19 0 4 298 L H b 1.7 5jg8_B 1 0 0 0 5 1 0 17 0 29 9 15 0 0 0 4 5 12 0 0 299 T H e 45.5 5jg8_B 14 0 5 4 5 6 0 0 6 1 0 9 0 12 9 0 24 4 0 0 300 T H e 32.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 1 0 0 8 0 1 0 4 5 5 0 30 0 9 8 10 18 0 0 0 301 V H b 0.7 5jg8_B 1 0 0 0 0 1 0 13 0 23 18 15 0 5 0 0 0 22 0 0 302 T H b 2.6 5jg8_B 8 0 0 5 0 0 5 0 0 0 0 0 0 4 10 23 40 4 0 0 303 A H e 52.7 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 9 0 13 11 0 0 0 0 4 0 7 17 0 5 9 4 13 3 5 0 304 L H b 14.0 5jg8_B NAG 0 0 4 0 0 0 0 10 7 48 4 0 0 0 0 0 17 10 0 0 L->P:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 305 V H b 0.0 5jg8_B 12 0 0 0 12 4 0 31 0 0 4 0 0 0 0 0 4 32 0 0 306 R H e 50.6 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 14 4 0 0 4 0 25 8 0 5 0 21 14 0 0 0 0 4 307 K H e 70.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 0 0 0 19 0 5 0 0 35 4 0 11 0 0 7 15 4 0 0 0 308 F H e 32.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 15 0 0 0 0 22 19 0 0 0 0 0 18 7 0 18 309 L H b 9.6 5jg8_B GOL 5 0 0 0 59 0 0 5 0 12 0 0 0 4 3 4 0 0 0 7 310 G T e 36.9 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 4 0 4 11 0 23 0 0 8 0 0 0 43 0 4 0 3 0 0 0 311 P T e 103.1 5jg8_B ASM_HUMAN:ASM3A_MOUSE:Sphingomyelin phosphodiesterase[528 aa]:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 7 0 26 6 0 5 0 0 13 0 0 17 11 0 0 9 0 4 0 0 312 V S e 22.0 5jg8_B ASM_HUMAN:ASM3A_MOUSE:Sphingomyelin phosphodiesterase[528 aa]:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 0 0 0 0 0 17 0 11 4 0 0 0 0 0 27 33 0 7 313 P e 31.8 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 0 0 0 0 0 0 15 0 0 0 69 11 0 4 0 0 0 0 314 V E b 0.0 5jg8_B 0 0 0 0 7 0 0 32 0 4 0 0 0 0 0 0 0 57 0 0 V->M:LP/P:rs1228068: Niemann-Pick disease B (NPDB) ; 315 Y E b 6.5 5jg8_B 0 0 0 0 20 0 0 19 0 5 0 0 0 0 0 0 0 26 0 30 Y->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 316 P E b 0.8 5jg8_B 7 0 0 0 5 0 0 0 0 0 0 0 72 0 0 5 0 5 5 0 317 A b 1.8 5jg8_B 46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 42 12 0 0 0 318 V b 0.7 5jg8_B 0 0 0 0 0 0 0 33 0 54 0 0 0 0 0 0 0 13 0 0 V->E:LB/B:rs1257513: -; 319 G b 0.0 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->R:LP/P:rs7579347: Niemann-Pick disease A (NPDA) ; 320 N S b 1.2 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:PO4:ACT 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" N->D:US:rs7799276: Niemann-Pick disease B (NPDB) ; 321 H S b 9.9 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:PO4:ACT 0 0 0 0 0 0 55 0 0 0 0 45 0 0 0 0 0 0 0 0 H->Y:LP/P:-: Niemann-Pick disease A (NPDA) ; 322 E S b 2.5 5jg8_B 0 0 68 32 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 323 S S b 1.6 5jg8_B GOL 5 0 0 0 7 15 0 15 0 0 0 0 0 0 0 16 0 30 0 11 324 T S b 7.8 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 1 0 0 0 24 1 7 0 0 10 0 0 0 0 0 0 8 15 12 19 T->I:LB/B:rs1050233: -;T->P:US:-: Niemann-Pick disease A (NPDA) ; 325 P S b 1.6 5jg8_B 1 0 0 0 0 1 0 0 0 1 0 0 94 0 0 0 0 0 0 0 P->A:LP/P:rs7613082: Niemann-Pick disease B (NPDB) ; 326 V T b 10.7 5jg8_B SCN:GOL 5 0 0 0 0 1 38 0 8 1 0 0 0 21 0 0 0 22 0 0 327 N T b 7.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 1 0 27 0 0 1 5 0 0 1 0 63 0 0 0 0 0 0 0 0 328 S b 2.3 5jg8_B 6 0 1 1 1 6 0 6 1 16 9 6 1 29 1 13 1 1 0 1 329 F b 0.0 5jg8_B 1 0 1 1 51 1 0 10 1 18 5 0 1 0 0 1 1 1 0 9 330 P b 2.3 5jg8_B 20 0 1 1 1 9 0 1 1 7 0 1 38 1 1 12 1 6 0 0 331 P b 0.8 5jg8_B 8 0 8 1 1 9 0 6 1 6 0 1 44 1 1 1 1 11 0 0 332 P T e 38.8 5jg8_B 3 1 2 3 2 3 16 2 2 4 1 2 34 2 2 7 2 3 1 8 P->R:LP/P:rs2020819: Niemann-Pick disease B (NPDB) ; 333 F T e 41.6 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. SO4 4 1 2 3 19 3 1 8 3 4 1 9 2 2 2 8 22 3 1 1 334 I S b 2.9 5jg8_B SO4 4 1 2 3 2 3 1 10 3 19 11 2 2 2 2 10 8 12 1 1 335 E e 77.4 5jg8_B SO4 4 1 7 11 2 3 1 2 8 8 1 2 8 24 2 3 3 3 1 6 336 G S e 46.4 5jg8_B 14 8 8 9 2 17 1 3 8 5 1 2 3 2 3 4 3 4 1 2 337 N S e 75.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 8 1 3 3 2 9 1 3 8 5 1 17 8 2 8 8 8 3 1 2 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." 338 H S e 31.9 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a.. SO4 4 1 9 3 7 8 4 2 3 9 1 7 8 11 7 3 3 3 1 7 339 S S b 7.0 5jg8_B 4 0 1 1 1 22 6 1 1 1 0 6 5 4 1 30 1 10 5 0 340 S S b 3.1 5jg8_B GOL 0 0 0 0 0 0 0 0 0 0 5 10 19 0 4 34 24 0 0 0 341 R H e 48.6 5jg8_B MLI:GOL:SO4 1 0 6 1 0 1 3 1 1 1 0 12 1 19 26 16 10 1 0 0 342 W H b 12.7 5jg8_B MLI:GOL:SO4 1 0 1 16 7 1 0 1 12 6 0 4 1 1 4 1 1 1 42 0 343 L H b 1.1 5jg8_B 0 0 0 0 0 0 0 16 0 52 10 0 0 0 0 0 0 12 0 8 L->P:LP/P:-: Niemann-Pick disease A (NPDA) ;L->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 344 Y H b 2.2 5jg8_B 1 0 0 1 13 1 0 0 1 6 0 0 0 0 0 1 15 1 0 60 345 E H e 45.7 5jg8_B MLI 1 0 10 24 1 1 0 1 16 1 0 18 1 6 11 7 1 1 0 0 346 A H b 17.0 5jg8_B 30 0 1 10 1 1 6 9 1 1 0 5 1 18 1 6 8 1 0 0 347 M T b 0.0 5jg8_B 2 0 1 1 10 2 0 10 1 16 22 1 1 1 1 2 1 21 0 6 348 A T b 3.6 5jg8_B 35 0 1 1 1 2 0 1 1 10 0 1 1 10 1 18 7 1 0 6 349 K T e 78.8 5jg8_B 1 0 6 15 0 6 6 1 9 5 0 12 1 9 12 1 11 1 0 4 350 A S b 19.6 5jg8_B 19 0 5 1 0 1 0 26 1 28 10 0 1 0 1 1 1 1 0 5 351 W S b 0.8 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 95 0 352 E T e 55.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 16 0 5 8 0 8 4 0 23 0 0 0 0 5 9 21 0 0 0 0 353 P T e 41.1 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 5 0 11 4 0 5 9 0 4 0 0 4 41 11 5 0 0 0 0 0 354 W T b 10.8 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 0 0 37 0 0 0 0 5 0 0 0 0 0 0 0 0 57 0 355 L S b 3.4 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 0 0 0 0 0 38 0 41 0 0 0 0 0 0 0 21 0 0 356 P e 48.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 11 0 0 3 0 0 0 0 0 4 63 0 0 17 3 0 0 0 357 A H e 61.6 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 22 0 0 33 0 0 0 0 0 0 0 12 4 9 0 4 7 4 0 5 358 E H e 62.8 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. SO4 17 0 21 47 0 5 0 0 0 0 0 7 0 4 0 0 0 0 0 0 359 A H b 0.0 5jg8_B 38 0 0 5 0 0 0 0 0 0 0 0 0 45 0 12 0 0 0 0 A->D:LP/P:rs7970448: Niemann-Pick disease B (NPDB) ; 360 L H b 7.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 4 0 0 5 0 0 0 20 5 21 0 0 0 15 15 0 0 11 0 4 361 R H e 58.5 5jg8_B 11 0 10 9 0 0 25 0 5 0 0 4 0 4 13 15 3 0 0 0 362 T H b 14.3 5jg8_B GOL 4 0 0 0 0 0 0 8 0 12 3 4 0 0 0 22 42 4 0 0 363 L H b 0.0 5jg8_B 0 0 0 0 57 0 0 0 0 34 0 0 0 0 0 0 0 10 0 0 L->R:US:-: Niemann-Pick disease A (NPDA) ; 364 R H e 41.5 5jg8_B GOL 0 0 11 19 0 0 0 0 20 12 0 4 0 14 16 4 0 0 0 0 365 I H e 51.5 5jg8_B GOL 0 0 0 5 5 0 4 8 25 5 0 0 0 0 27 0 0 0 0 21 366 G T b 1.2 5jg8_B 0 0 8 0 0 58 0 0 0 0 0 5 0 0 21 4 0 0 0 4 367 G S b 0.0 5jg8_B 31 0 0 0 0 55 0 0 0 0 0 0 0 0 0 9 4 0 0 0 368 F b 6.2 5jg8_B GOL 0 5 0 0 27 0 0 0 0 0 0 0 0 0 0 32 0 0 5 31 369 Y E b 0.4 5jg8_B 0 0 0 0 36 0 0 0 0 0 0 0 0 0 0 0 0 0 0 64 Y->C:LP/P:rs3722878: Niemann-Pick disease A (NPDA) ; 370 A E b 7.1 5jg8_B 12 4 0 0 19 0 0 0 0 10 5 0 0 0 0 21 17 7 0 5 371 L E b 5.1 5jg8_B 0 5 0 12 0 0 0 0 9 12 0 0 0 4 0 5 13 41 0 0 372 S e 50.8 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 6 0 5 33 0 0 0 0 13 9 0 0 4 5 0 15 5 0 0 5 373 P S b 16.3 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL 4 0 0 0 0 0 0 14 0 0 0 3 27 0 0 6 3 44 0 0 P->S:LP/P:rs1342372: Niemann-Pick disease B (NPDB) ; 374 Y S b 7.4 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL:SO4 0 0 0 0 0 0 0 38 10 0 5 11 0 4 5 12 0 7 0 8 375 P T e 79.1 5jg8_B NAG 0 0 10 5 0 4 0 0 0 0 0 0 63 0 4 11 4 0 0 0 376 G T e 44.0 5jg8_B 7 0 17 0 0 61 0 0 3 0 0 12 0 0 0 0 0 0 0 0 377 L E b 0.6 5jg8_B 0 0 0 0 5 7 0 0 0 88 0 0 0 0 0 0 0 0 0 0 378 R E b 13.0 5jg8_B SO4 38 0 0 0 0 0 0 0 10 0 0 0 0 0 45 0 7 0 0 0 R->H:LP/P:rs5590880: Niemann-Pick disease B (NPDB) ;R->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 379 L E b 0.0 5jg8_B 5 0 0 0 0 0 0 32 0 17 5 0 0 0 0 0 0 40 0 0 380 I E b 0.0 5jg8_B 0 0 0 0 5 0 0 71 0 11 5 0 0 0 0 0 0 7 0 0 381 S E b 0.8 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 88 5 7 0 0 S->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 382 L b 0.0 5jg8_B 0 0 0 0 8 0 0 13 0 79 0 0 0 0 0 0 0 0 0 0 383 N b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 384 M G b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 12 5 0 0 0 0 83 0 0 0 M->I:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ;M->I:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 385 N G b 0.0 5jg8_B 0 0 0 0 0 5 0 11 0 43 0 31 0 0 0 0 0 10 0 0 N->S:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 386 F G b 0.0 5jg8_B 0 0 0 5 22 0 0 0 0 26 0 0 0 0 0 0 0 0 4 44 387 C G b 0.0 5jg8_B 0 21 0 0 14 5 0 0 0 17 4 5 0 0 0 0 0 0 4 30 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 388 S b 1.6 5jg8_B C5P:AP2 MLI 0 0 10 5 25 0 0 0 0 0 0 4 0 0 0 25 0 0 0 31 389 R S e 47.4 5jg8_B 0 0 10 5 0 11 0 0 20 0 5 14 0 4 13 4 4 12 0 0 390 E S e 59.3 5jg8_B NT8 ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] SO4 12 0 0 12 5 8 0 10 12 0 0 4 11 0 5 16 5 0 0 0 391 N b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 N->T:LP/P:-: Niemann-Pick disease A (NPDA) ;N->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 392 F G b 11.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] 16 0 1 1 28 2 0 9 8 6 0 1 9 1 6 2 6 1 0 1 393 W G b 0.0 5jg8_B 8 1 1 6 6 7 1 1 2 7 5 8 5 6 1 5 2 2 13 14 W->G:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ;W->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 394 L G b 0.6 5jg8_B 0 5 0 0 0 0 0 0 0 38 8 5 11 4 0 4 12 13 0 0 395 L G b 17.4 5jg8_B 4 9 5 0 7 0 0 0 0 29 0 0 0 0 4 0 19 8 0 15 396 I T b 18.1 5jg8_B 13 0 22 4 0 0 0 13 0 22 0 0 0 0 0 7 0 16 0 0 397 N e 45.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. GOL:SO4 0 0 20 4 0 4 4 0 0 0 0 51 5 0 0 5 7 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." 398 S b 7.0 5jg8_B NAG GOL:SO4 0 4 0 5 0 0 0 0 16 5 7 17 12 13 0 16 5 0 0 0 399 T S e 37.0 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. SO4:GOL 7 11 0 0 0 0 0 0 9 5 0 9 0 7 0 10 37 5 0 0 400 D S b 9.9 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. 0 0 82 5 0 5 0 0 0 0 0 4 0 0 0 4 0 0 0 0 401 P G b 3.9 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. 0 0 0 5 0 0 0 0 4 0 0 4 79 0 0 7 0 0 0 0 402 A G e 31.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. GOL 32 7 15 0 0 24 0 0 8 0 0 5 5 0 3 0 0 0 0 0 403 G G e 41.7 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose.. GOL 13 0 0 4 0 30 4 0 21 0 0 20 0 4 0 5 0 0 0 0 404 Q H b 0.0 5jg8_B 0 0 0 8 0 0 4 0 4 4 4 0 0 55 0 10 10 0 0 0 405 L H b 0.0 5jg8_B 0 0 0 0 26 0 0 0 0 55 15 0 0 0 0 5 0 0 0 0 406 Q H e 36.7 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. GOL 7 0 9 25 0 0 0 0 0 20 0 0 0 21 9 5 0 4 0 0 407 W H e 23.5 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. GOL 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 408 L H b 0.0 5jg8_B 0 0 0 0 15 0 0 4 0 73 5 0 0 0 0 0 0 4 0 0 409 V H b 0.7 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. NO3 0 0 0 26 0 27 0 15 5 0 0 5 0 0 5 0 0 17 0 0 410 G H e 52.4 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. 0 0 11 12 4 5 0 11 5 0 0 19 0 7 0 7 0 8 0 11 411 E H b 18.1 5jg8_B alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. 0 0 0 17 0 0 0 0 0 0 0 0 0 27 0 0 32 23 0 0 412 L H b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 413 Q H b 7.1 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. 5 0 7 19 5 0 5 7 4 0 0 16 0 25 0 4 4 0 0 0 414 A H e 27.7 5jg8_B FUC 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. 24 0 13 28 0 0 0 8 0 0 0 15 0 5 0 6 0 0 0 0 415 A H b 0.9 5jg8_B 37 0 0 0 4 0 0 3 0 8 17 0 0 0 0 25 0 0 0 5 A->V:LP/P:rs1451199: Niemann-Pick disease B (NPDB) ; 416 E H b 18.1 5jg8_B GOL 0 0 0 27 0 0 0 0 7 6 0 0 0 11 38 12 0 0 0 0 417 D H e 72.2 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. GOL 8 0 13 9 0 0 0 0 9 10 0 12 0 21 7 9 0 0 3 0 418 R H e 50.6 5jg8_B FUC 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al..:alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-bet.. 15 0 4 0 0 0 0 4 15 0 0 16 0 0 41 0 0 5 0 0 419 G T e 73.8 5jg8_B 0 0 0 0 0 80 0 0 11 0 0 8 0 0 0 0 0 0 0 0 420 D b 5.6 5jg8_B 0 0 17 38 0 0 0 0 0 0 38 7 0 0 0 0 0 0 0 0 421 K E e 25.9 5jg8_B 0 0 0 0 0 0 0 0 67 5 7 0 0 9 5 7 0 0 0 0 422 V E b 0.7 5jg8_B 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95 0 0 423 H E b 0.5 5jg8_B 0 0 0 0 0 0 18 5 0 5 0 0 0 0 0 0 0 0 37 35 H->Y:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ;H->R:LP/P:rs7674920: Niemann-Pick disease A (NPDA) ; 424 I E b 0.6 5jg8_B 0 0 0 0 0 0 0 49 0 39 0 0 0 0 0 0 0 12 0 0 425 I E b 1.2 5jg8_B 0 0 0 0 0 0 0 44 0 10 5 0 0 0 0 23 4 13 0 0 426 G E b 0.0 5jg8_B 22 0 0 0 0 74 0 0 0 0 0 0 0 0 0 5 0 0 0 0 G->S:LP/P:rs1554935: Niemann-Pick disease A (NPDA) ; 427 H S b 0.0 5jg8_B RP5:C5P:AP2:NT8:PC ZN MLI:PO4:ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" H->R:LP/P:rs7947276: Niemann-Pick disease B (NPDB) ; 428 I S b 2.9 5jg8_B 0 0 0 0 0 0 0 44 0 0 0 0 0 0 0 0 0 56 0 0 429 P b 0.0 5jg8_B 0 0 0 0 7 0 0 0 0 0 0 0 93 0 0 0 0 0 0 0 430 P T b 0.0 5jg8_B 0 0 5 0 0 0 0 0 5 0 0 0 78 0 0 0 0 11 0 0 431 G T e 20.2 5jg8_B 9 0 4 0 0 67 0 0 4 0 0 8 0 0 0 5 0 0 0 0 432 H S e 44.5 5jg8_B SO4 5 0 4 14 8 0 12 0 4 0 0 4 0 6 6 9 0 0 0 28 433 C S b 0.0 5jg8_B RP5:PC GOL 5 33 0 0 11 0 0 7 0 10 6 8 0 0 0 5 5 0 5 4 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:rs7795285: Niemann-Pick disease B (NPDB) ; 434 L b 12.9 5jg8_B 4 0 4 12 0 0 0 4 5 30 0 0 3 7 9 0 5 0 0 17 L->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 435 K S e 44.3 5jg8_B NAG GOL 0 0 17 16 0 7 0 0 41 0 0 4 0 6 4 7 0 0 0 0 436 S H b 10.2 5jg8_B NAG GOL 0 0 5 0 0 20 0 0 8 9 0 8 0 0 0 25 10 0 0 13 437 W H b 1.2 5jg8_B GOL 4 13 5 0 11 0 3 0 0 4 0 0 0 3 0 3 0 0 38 15 W->C:LP/P:-: Niemann-Pick disease B (NPDB) ; 438 S H b 0.0 5jg8_B NAG 15 8 9 0 0 0 0 0 7 0 0 19 0 0 0 20 0 8 0 14 S->R:LP/P:rs2676070: Niemann-Pick disease B (NPDB) ; 439 W H e 35.1 5jg8_B SO4:PO4 5 0 4 20 10 0 0 3 0 9 0 0 0 4 0 7 5 0 30 3 440 N H b 3.6 5jg8_B NO3 1 0 4 4 0 1 0 0 17 1 5 27 0 17 5 10 3 0 4 0 441 Y H b 0.0 5jg8_B 1 4 0 0 15 1 0 0 9 17 0 0 0 0 0 1 5 0 0 44 442 Y H b 0.0 5jg8_B 4 0 0 5 15 5 5 4 0 15 0 0 0 0 0 1 6 3 0 35 443 R H e 25.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. NO3 1 0 23 5 0 1 0 1 20 5 0 10 1 9 11 10 1 1 0 0 444 I H b 0.6 5jg8_B NO3 1 0 1 1 0 1 0 41 5 19 0 1 1 1 1 5 1 18 4 0 445 V H b 2.0 5jg8_B 5 0 0 0 20 0 0 17 0 19 7 0 0 0 0 0 7 22 0 0 446 A H b 3.6 5jg8_B 6 0 0 3 0 5 11 0 5 5 0 9 0 12 18 12 8 0 0 6 447 R H b 9.5 5jg8_B SO4:NO3 0 0 7 29 0 0 0 0 13 0 0 0 0 15 36 0 0 0 0 0 448 Y T b 0.9 5jg8_B NO3 0 0 0 0 15 0 7 0 0 0 0 0 0 0 0 0 0 0 0 77 Y->C:LP/P:rs7471433: Niemann-Pick disease A (NPDA) ; 449 E T b 7.5 5jg8_B ZN 5 0 0 16 0 0 7 0 0 0 0 0 0 11 30 30 0 0 0 0 450 N T e 30.9 5jg8_B ZN 0 0 58 0 0 0 0 0 0 0 0 18 0 0 7 11 7 0 0 0 451 T T b 6.5 5jg8_B 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 38 37 0 0 452 L E b 6.7 5jg8_B 0 0 0 0 0 0 0 82 0 8 0 0 0 0 0 0 0 11 0 0 L->P:LP/P:-: Niemann-Pick disease A (NPDA) ; 453 A E b 12.5 5jg8_B 36 0 0 5 0 0 0 24 0 4 0 0 0 0 0 0 7 24 0 0 A->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 454 A E b 3.6 5jg8_B 18 0 0 0 5 67 0 0 0 0 0 0 0 5 0 5 0 0 0 0 A->V:LP/P:rs1402734: Niemann-Pick disease B (NPDB) ; 455 Q E b 0.0 5jg8_B 0 0 0 0 0 32 9 0 0 0 5 0 0 47 0 8 0 0 0 0 456 F E b 0.0 5jg8_B 0 0 0 0 56 0 0 5 0 30 0 0 0 0 0 0 0 9 0 0 457 F E b 0.0 5jg8_B 0 0 0 0 46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 54 458 G E b 0.0 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 459 H E b 18.8 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:GOL:PO4:ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 460 T E b 15.6 5jg8_B C5P:NT8:PC:YA4 GOL:SO4 0 0 5 5 0 0 7 7 0 0 38 0 0 0 0 0 38 0 0 0 461 H E b 8.9 5jg8_B C5P:RP5:PC:AP2:AMP:NT8:YA4 ZN MLI:SO4:GOL:PO4:ACT 0 0 0 0 0 0 62 0 0 0 0 38 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 462 V S b 13.3 5jg8_B C5P:AP2:AMP GOL 0 0 0 0 0 0 0 22 0 5 7 0 0 0 22 5 12 16 0 10 463 D b 5.6 5jg8_B 0 0 89 5 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 464 E E b 6.5 5jg8_B 0 0 0 19 0 0 38 0 5 0 0 0 0 10 0 19 5 0 0 5 465 F E b 2.9 5jg8_B 0 0 0 0 82 0 0 13 0 6 0 0 0 0 0 0 0 0 0 0 F->S:LP/P:rs1319643: Niemann-Pick disease A (NPDA) ; 466 E E b 2.5 5jg8_B 2 0 1 11 1 1 0 1 1 2 20 1 1 1 15 20 7 8 0 7 467 V E b 0.0 5jg8_B 0 0 0 0 13 0 0 11 0 5 15 0 0 0 0 0 0 56 0 0 468 F E b 0.0 5jg8_B 0 0 0 0 47 0 0 8 0 19 7 0 0 9 0 0 0 0 0 11 469 Y E b 3.5 5jg8_B 0 0 0 0 9 0 8 6 0 8 0 0 0 0 0 21 0 0 0 49 Y->S:LP/P:rs2676070: Niemann-Pick disease A (NPDA) ; 470 D b 5.6 5jg8_B 7 0 79 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 471 E T e 40.2 5jg8_B 0 0 29 23 8 0 0 0 15 0 0 9 0 0 0 0 0 13 0 0 472 E T e 75.4 5jg8_B 12 0 27 11 0 1 0 1 8 1 0 19 15 1 1 1 1 1 0 0 473 T T e 52.6 5jg8_B 2 0 6 8 1 6 0 1 9 2 0 12 7 1 1 10 17 8 0 7 474 L S b 18.5 5jg8_B 2 0 7 1 1 2 7 1 8 35 0 7 6 1 1 8 6 6 0 1 475 S e 60.9 5jg8_B 2 0 1 8 1 21 6 1 1 2 0 1 1 1 7 29 16 1 0 1 476 R S e 37.2 5jg8_B CL 6 0 1 7 1 1 0 8 11 1 0 17 1 1 26 10 8 1 0 0 R->W:LP/P:rs1828129: Niemann-Pick disease B (NPDB) ;R->Q:US:rs7635669: Niemann-Pick disease B (NPDB) ; 477 P E b 13.2 5jg8_B 1 0 10 1 0 1 0 0 1 1 0 9 73 0 0 1 1 1 0 0 P->L:LP/P:rs7535088: Niemann-Pick disease A (NPDA) ;P->L:LP/P:rs7535088: Niemann-Pick disease B (NPDB) ; 478 L E b 9.0 5jg8_B 1 0 0 1 7 1 9 29 1 15 6 0 0 0 0 1 20 8 0 0 479 A E b 6.2 5jg8_B 8 0 0 1 0 14 6 0 1 1 0 42 0 0 0 15 1 1 0 9 480 V E b 6.7 5jg8_B 5 0 0 1 16 1 0 7 1 1 7 0 0 0 0 16 1 43 0 0 481 A E b 0.0 5jg8_B 11 0 0 1 0 16 0 6 1 9 25 13 0 0 0 1 1 14 0 0 482 F E b 2.9 5jg8_B 1 0 0 1 50 1 0 0 1 1 0 0 0 10 0 1 1 1 6 26 F->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 483 L E b 0.0 5jg8_B 7 0 0 1 0 1 0 27 1 31 0 0 0 0 0 7 6 16 0 0 484 A E b 0.0 5jg8_B 42 0 0 1 0 10 0 0 1 1 0 0 0 0 0 19 16 7 0 0 A->E:LP/P:rs2676070: Niemann-Pick disease A (NPDA) ; 485 P E b 1.6 5jg8_B 0 0 0 0 0 9 0 0 0 0 0 0 82 0 0 9 0 0 0 0 486 S b 0.0 5jg8_B 15 0 0 0 0 10 0 0 0 9 0 0 0 0 0 57 0 9 0 0 487 A S b 0.0 5jg8_B 19 0 9 0 0 0 0 9 0 19 0 0 0 0 0 0 0 43 0 0 A->V:LB/B:rs1416412: -; 488 T S b 0.0 5jg8_B PC GOL 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 91 0 0 0 T->A:LP/P:-: Niemann-Pick disease B (NPDB) ; 489 T b 0.0 5jg8_B 0 0 0 13 0 0 0 0 0 0 0 9 33 0 0 0 45 0 0 0 490 Y T e 22.2 5jg8_B C5P GOL:SO4 0 0 0 0 10 0 0 0 0 10 0 0 0 0 4 18 0 20 6 32 Y->N:LP/P:rs3981234: Niemann-Pick disease B (NPDB) ; 491 I T e 56.7 5jg8_B C5P:NT8 GOL:SO4 0 0 6 6 0 0 0 19 11 4 6 0 10 12 0 7 0 0 0 18 492 G T e 20.2 5jg8_B GOL 0 0 16 0 9 33 5 0 0 0 0 16 0 0 0 4 4 0 6 6 G->S:LP/P:rs1448733: Niemann-Pick disease B (NPDB) ; 493 L b 4.5 5jg8_B GOL 0 0 0 0 0 0 7 18 0 16 0 13 0 18 0 0 0 21 0 7 494 N b 2.4 5jg8_B 0 0 0 8 7 0 0 0 11 0 0 74 0 0 0 0 0 0 0 0 N->I:LP/P:-: Niemann-Pick disease A (NPDA) ; 495 P b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 496 G E b 0.0 5jg8_B 26 0 0 0 0 46 0 0 11 0 0 0 0 0 0 6 10 0 0 0 G->S:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 497 Y E b 1.7 5jg8_B 0 0 0 0 16 0 0 14 0 7 0 0 0 0 0 0 0 12 0 51 498 R E b 0.4 5jg8_B 0 0 0 0 0 0 0 0 10 0 0 0 0 0 79 0 0 11 0 0 R->L:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ;R->C:LP/P:rs7699047: Niemann-Pick disease B (NPDB) ;R->H:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 499 V E b 0.0 5jg8_B GOL 0 0 0 0 0 0 0 40 11 22 0 0 0 10 0 0 0 16 0 0 500 Y E b 0.0 5jg8_B 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 11 0 0 0 47 501 Q E b 12.2 5jg8_B GOL:SO4:PO4 0 0 0 31 0 0 0 0 0 11 0 0 0 34 0 0 24 0 0 0 502 I E b 0.6 5jg8_B 3 1 2 3 9 3 1 46 2 4 1 2 2 2 2 3 2 9 1 1 503 D E b 1.9 5jg8_B 3 1 60 3 2 3 1 2 2 4 1 2 2 2 2 3 2 3 1 1 504 G b 1.2 5jg8_B 16 1 3 4 2 29 1 3 3 5 1 3 3 2 3 10 3 4 1 2 505 N S e 45.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 4 1 3 4 2 11 1 3 3 5 1 20 3 14 3 4 3 11 1 2 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." 506 Y S e 30.0 5jg8_B GOL 2 0 1 1 1 2 8 1 1 2 0 1 1 1 1 1 1 1 0 72 507 S T e 89.1 5jg8_B 12 0 29 7 1 1 0 1 16 1 0 7 12 1 1 8 1 1 0 0 S->G:LB/B:-: -; 508 G T e 94.0 5jg8_B GOL 1 0 1 1 1 26 0 8 1 2 0 1 17 1 11 11 1 1 0 15 G->R:LB/B:rs1050239: -; 509 S b 4.7 5jg8_B 18 0 1 1 1 9 0 1 1 2 0 8 1 11 9 27 8 1 0 1 510 S b 6.2 5jg8_B 1 0 16 1 0 1 0 1 8 1 0 1 1 0 1 29 39 1 0 0 MOD_RES:/note="Phosphoserine; by PKC/PRKCD":MUTAGEN:/note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762":MOD_RES:/note="Phosphoserine; by PKC/PRKCD":MUTAGEN:/note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" S->F:LB/B:rs2006526: -; 511 H b 2.6 5jg8_B 1 0 1 1 14 7 11 1 11 11 0 8 1 0 1 1 1 1 0 30 512 V b 14.7 5jg8_B 8 0 1 1 0 1 0 1 16 1 0 16 1 15 1 6 15 12 0 7 513 V E b 4.0 5jg8_B 1 0 1 1 0 1 0 25 1 40 0 1 1 0 1 1 1 26 0 0 514 L E b 19.1 5jg8_B 1 0 1 1 0 1 0 8 18 35 6 1 1 0 1 1 11 15 0 0 515 D E b 15.4 5jg8_B SO4 0 0 75 17 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 516 H E b 1.0 5jg8_B 7 0 0 0 7 0 11 10 0 17 21 0 0 0 0 6 0 0 0 22 H->Q:LP/P:-: Niemann-Pick disease B (NPDB) ; 517 E E b 3.0 5jg8_B GOL 0 0 0 19 0 0 0 0 7 12 0 0 11 0 0 6 17 14 0 14 E->V:LP/P:rs1427870: Niemann-Pick disease B (NPDB) ; 518 T E b 0.0 5jg8_B 10 0 0 7 0 0 0 0 0 0 0 0 0 30 0 0 53 0 0 0 519 Y E b 6.5 5jg8_B GOL 0 0 0 0 18 0 0 0 0 0 0 0 0 0 0 0 0 0 7 75 Y->C:LP/P:rs3718372: Niemann-Pick disease A (NPDA) ; 520 I E b 1.2 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 0 0 0 0 34 0 14 11 0 0 0 0 11 0 0 0 0 0 7 23 I->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 521 L E b 0.0 5jg8_B 21 0 0 11 7 0 0 0 0 29 9 0 0 0 0 10 13 0 0 0 522 N e 23.0 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 23 0 0 0 0 0 0 0 0 77 0 0 0 0 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." N->S:LP/P:-: Niemann-Pick disease B (NPDB) ; 523 L H b 0.0 5jg8_B 0 0 0 0 0 0 0 8 0 76 0 0 0 0 0 0 0 17 0 0 524 T H e 57.1 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. SO4 0 0 0 7 0 0 0 0 0 0 0 0 0 0 5 11 66 0 0 10 525 Q H e 62.2 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. GOL 0 0 11 40 0 0 0 10 7 0 0 0 0 24 0 7 0 0 0 0 Q->H:LP/P:-: Niemann-Pick disease B (NPDB) ; 526 A H b 2.7 5jg8_B 65 0 0 11 0 0 0 0 0 0 0 14 0 0 0 10 0 0 0 0 527 N T e 24.2 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 0 0 11 0 0 7 0 0 0 75 0 0 0 0 7 0 0 0 528 I S e 56.7 5jg8_B NAG ASM_HUMAN:ASM3A_MOUSE:Sphingomyelin phosphodiesterase[528 aa]:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 17 0 0 12 0 1 0 11 0 44 7 0 0 0 0 1 0 6 0 0 529 P T e 96.1 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM_HUMAN:ASM3A_MOUSE:Sphingomyelin phosphodiesterase[528 aa]:Acid sphingomyelinase-like phosphodiesterase 3a[41.. GOL 4 0 0 7 0 0 0 0 32 0 0 25 7 10 0 7 8 0 0 0 530 G T e 96.4 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 0 0 7 0 0 74 0 0 0 0 0 7 8 0 0 0 0 0 0 0 531 A e 33.9 5jg8_B ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. SO4 15 0 0 21 0 4 10 0 20 0 0 7 0 0 0 0 24 0 0 0 532 I e 83.0 5jg8_B 2 1 1 8 1 2 1 12 9 10 11 9 1 1 1 2 14 13 0 1 533 P e 20.2 5jg8_B SO4 1 0 8 1 1 13 0 1 1 2 0 1 42 1 1 17 1 9 0 1 534 H e 67.0 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM3A_MOUSE:Acid sphingomyelinase-like phosphodiesterase 3a[41.. 1 0 0 7 0 0 7 4 8 1 0 41 0 0 11 4 7 8 0 0 535 W E b 7.2 5jg8_B 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 81 11 W->R:LP/P:rs1554935: Niemann-Pick disease A (NPDA) ;W->R:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 536 Q E e 30.6 5jg8_B NAG ZN 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 25 0 0 0 0 12 6 0 0 0 18 0 11 18 7 0 4 537 L e 31.5 5jg8_B SO4 0 0 0 10 0 0 0 0 7 66 0 0 0 5 4 0 0 7 0 0 538 L e 25.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. 0 0 0 55 0 0 0 0 0 29 0 0 0 0 0 7 8 0 0 0 539 Y b 4.8 5jg8_B NO3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 Y->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 540 R B e 36.4 5jg8_B GOL:SO4 0 0 18 0 0 0 0 4 0 0 0 12 0 14 26 16 4 4 0 0 541 A H b 0.0 5jg8_B 45 0 0 0 11 0 0 0 0 29 0 0 0 0 0 0 15 0 0 0 542 R H e 41.1 5jg8_B SO4 0 0 0 0 0 0 0 0 8 0 0 8 0 0 28 0 44 11 0 0 543 E H e 78.9 5jg8_B GOL:SO4 0 0 0 48 0 0 0 0 0 0 8 7 0 25 0 11 0 0 0 0 544 T H e 31.8 5jg8_B NO3 33 0 0 8 8 0 7 11 0 8 0 0 0 0 0 0 24 0 0 0 545 Y H b 3.5 5jg8_B 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 84 546 G T e 65.5 5jg8_B 0 0 20 0 0 39 0 0 0 0 0 23 0 13 0 4 0 0 0 0 547 L b 2.8 5jg8_B 0 0 0 0 0 0 0 27 0 21 24 0 0 0 0 0 8 20 0 0 548 P S e 69.0 5jg8_B 16 0 27 4 8 0 0 0 8 0 0 0 32 5 0 0 0 0 0 0 549 N e 32.1 5jg8_B 0 0 57 0 0 8 0 0 0 0 0 34 0 0 0 0 0 0 0 0 N->K:LP/P:-: Niemann-Pick disease B (NPDB) ; 550 T S b 1.9 5jg8_B 20 0 0 0 7 0 0 0 0 49 0 0 0 20 0 0 4 0 0 0 551 L S e 26.4 5jg8_B 0 0 0 0 0 0 0 8 0 8 4 0 0 18 0 43 7 0 0 11 L->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 552 P H b 19.4 5jg8_B 6 0 0 0 0 11 0 0 0 0 0 0 77 0 0 0 0 6 0 0 553 T H e 48.7 5jg8_B 4 0 0 4 0 0 6 18 13 8 0 0 0 7 0 6 25 8 0 0 554 A H b 6.2 5jg8_B SCN 8 0 0 8 0 11 0 0 0 0 0 0 0 0 0 72 0 0 0 0 555 W H b 1.2 5jg8_B 0 0 0 0 0 0 0 0 0 29 26 0 0 0 0 0 0 0 36 8 556 H H b 17.8 5jg8_B GOL 0 0 7 0 0 0 29 0 0 0 0 27 0 0 0 7 8 0 0 21 557 N H e 50.9 5jg8_B 4 0 12 8 0 9 0 0 21 7 0 9 0 8 0 11 12 0 0 0 558 L H b 0.0 5jg8_B 21 0 0 0 0 0 0 0 0 49 8 0 0 0 0 0 0 22 0 0 559 V H b 0.7 5jg8_B 22 0 0 0 0 0 0 23 0 12 11 0 0 0 0 7 0 17 0 8 560 Y H e 23.9 5jg8_B GOL 0 0 13 20 0 0 0 0 9 8 0 8 0 23 0 0 6 0 0 13 561 R H e 37.9 5jg8_B 0 0 0 0 0 0 0 0 15 8 0 7 0 26 44 0 0 0 0 0 562 M H b 1.4 5jg8_B 0 0 0 0 13 0 0 26 0 19 41 0 0 0 0 0 0 0 0 0 563 R H e 30.0 5jg8_B GOL:SO4 21 0 0 0 8 0 0 0 17 0 0 7 0 8 13 0 9 11 7 0 564 G H e 76.2 5jg8_B GOL:SO4 0 0 4 0 0 10 0 4 8 0 0 0 0 5 0 32 36 0 0 0 565 D e 42.0 5jg8_B GOL:SO4 0 0 40 11 0 0 0 0 0 0 0 16 0 0 0 26 0 8 0 0 D->Y:LP/P:-: Niemann-Pick disease B (NPDB) ; 566 M H e 30.9 5jg8_B GOL:SO4 0 0 8 12 0 0 0 0 0 0 4 18 6 6 0 26 19 0 0 0 567 Q H e 77.0 5jg8_B SO4 0 0 0 0 0 0 6 0 25 0 0 0 0 13 0 40 16 0 0 0 568 L H b 14.6 5jg8_B 0 0 0 0 0 0 0 17 8 29 15 0 0 25 0 0 6 0 0 0 569 F H b 0.0 5jg8_B 0 0 0 0 66 0 0 0 0 26 0 0 0 0 8 0 0 0 0 0 570 Q H e 37.2 5jg8_B GOL 0 0 0 15 0 0 0 9 0 16 0 28 0 24 7 0 0 0 0 0 571 T H e 33.1 5jg8_B NO3 0 0 15 0 0 0 0 0 42 0 0 11 0 0 12 8 13 0 0 0 572 F H b 1.9 5jg8_B 0 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 72 F->L:LP/P:-: Niemann-Pick disease A (NPDA) ; 573 W H b 13.1 5jg8_B 2 0 1 1 1 2 17 1 1 2 0 1 1 1 1 2 1 10 15 39 574 F H e 45.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. GOL 0 0 0 9 32 0 9 0 6 0 0 5 0 9 8 0 0 8 0 13 575 L H b 3.9 5jg8_B 1 0 0 9 0 1 8 0 0 23 0 10 0 0 0 1 1 14 0 29 576 Y H b 17.8 5jg8_B NO3 9 0 0 0 16 0 9 0 0 0 0 9 0 0 0 0 0 0 0 57 577 H T b 11.5 5jg8_B NT8 0 0 0 0 29 0 14 0 0 9 0 31 0 0 0 0 0 0 0 16 H->D:US:-: Niemann-Pick disease B (NPDB) ; 578 K T b 0.0 5jg8_B 0 0 0 0 0 0 0 0 14 0 0 0 0 0 27 39 0 20 0 0 K->N:LP/P:rs7473424: Niemann-Pick disease B (NPDB) ; 579 G T e 20.2 5jg8_B NAG alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. SO4 8 0 0 0 0 14 0 0 0 0 0 17 0 0 9 29 0 22 0 0 G->S:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 580 H e 34.0 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL:SO4 0 0 0 0 9 0 23 0 0 0 0 0 0 0 0 31 0 0 0 38 581 P e 36.4 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL 0 0 30 0 0 0 0 0 0 0 0 0 31 0 0 9 0 0 0 30 582 P e 51.9 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL:SO4 0 0 0 8 0 9 0 9 0 0 0 15 32 0 0 27 0 0 0 0 583 S S e 102.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] GOL:SO4 7 0 0 0 0 0 7 0 9 0 0 8 0 9 9 43 9 0 0 0 584 E S e 79.4 5jg8_B GOL:SO4 19 0 0 32 0 7 0 0 17 8 0 0 0 0 0 1 1 11 0 0 585 P e 84.5 5jg8_B SO4 1 0 1 1 1 10 0 7 1 2 0 1 37 1 1 10 17 8 0 1 586 C b 18.7 5jg8_B SO4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 587 G e 21.4 5jg8_B GOL:SO4 0 0 47 7 0 14 0 0 0 0 0 9 0 6 0 0 8 0 0 8 588 T H e 55.2 5jg8_B GOL:SO4 0 0 7 15 0 6 0 0 5 0 0 0 0 28 0 17 23 0 0 0 589 P H e 79.8 5jg8_B ZN SO4 15 0 0 0 0 0 5 9 14 0 0 0 14 9 5 15 14 0 0 0 590 C H e 21.3 5jg8_B SO4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 591 R H b 8.7 5jg8_B GOL 0 0 0 0 0 0 0 0 37 0 0 0 0 18 39 7 0 0 0 0 592 L H e 27.5 5jg8_B GOL 5 0 0 0 0 0 0 13 9 22 15 9 0 0 0 0 18 0 0 8 593 A H e 58.0 5jg8_B 14 0 8 7 11 9 0 9 9 9 0 0 0 15 0 0 8 0 0 0 594 T H b 8.4 5jg8_B 0 0 0 0 8 0 13 0 0 9 0 0 0 29 0 0 14 0 9 17 595 L H b 0.0 5jg8_B GOL 0 0 0 0 0 0 0 33 0 32 9 0 0 0 0 0 0 26 0 0 596 C H e 26.7 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 597 A H e 36.6 5jg8_B 57 0 11 0 0 0 0 0 10 0 0 11 0 0 0 11 0 0 0 0 598 Q H b 1.0 5jg8_B GOL 0 0 0 0 0 0 0 41 0 13 20 7 0 19 0 0 0 0 0 0 Q->R:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 599 L H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 23 26 21 0 0 9 21 0 0 0 0 0 L->F:US:rs1385319: Niemann-Pick disease B (NPDB) ; 600 S b 19.5 5jg8_B 0 0 7 0 0 0 9 0 12 0 13 21 0 9 0 31 0 0 0 0 601 A b 0.9 5jg8_B 31 0 0 0 0 24 0 0 0 21 0 0 0 0 0 7 0 18 0 0 602 R S b 7.9 5jg8_B SO4:PO4 20 0 29 0 0 0 13 0 0 0 7 0 0 0 31 0 0 0 0 0 R->H:LP/P:rs3701290: Niemann-Pick disease A (NPDA) ;R->H:LP/P:rs3701290: Niemann-Pick disease B (NPDB) ;R->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 603 A T b 5.4 5jg8_B 13 0 0 0 9 0 13 9 0 6 0 7 0 0 0 25 0 8 0 11 604 D T e 49.4 5jg8_B SO4:PO4 0 0 28 0 0 0 0 14 0 11 0 22 0 0 0 0 0 6 0 18 605 S b 8.6 5jg8_B ZN GOL:SO4:PO4 9 0 18 0 0 0 0 0 11 0 0 0 0 0 0 53 9 0 0 0 S->G:LB/B:-: -; 606 P G e 83.7 5jg8_B SO4:PO4 0 0 7 12 0 0 0 0 0 0 0 0 19 0 0 0 13 0 0 50 607 A G e 48.2 5jg8_B GOL:SO4:PO4 35 7 0 6 0 0 0 0 0 13 0 0 0 0 0 12 17 0 0 11 608 L G b 5.1 5jg8_B 0 0 21 11 12 0 0 0 0 26 0 0 0 0 0 0 18 0 0 13 609 C G b 12.7 5jg8_B 0 93 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 610 R G e 54.5 5jg8_B 1 0 16 1 0 1 0 15 1 13 0 1 1 11 37 1 1 1 0 0 R->C:US:rs3759151: Niemann-Pick disease B (NPDB) ; 611 H G e 49.7 5jg8_B GOL 1 0 1 1 0 1 89 1 1 1 0 1 1 0 1 1 1 1 0 0 612 L G b 1.1 5jg8_B 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 613 M e 84.5 5jg8_B 0 0 0 0 0 0 0 0 0 0 41 0 0 0 0 0 0 20 0 39 614 P e 130.2 5fic_B 39 0 0 0 0 0 0 0 0 0 0 0 61 0 0 0 0 0 0 0 615 D 0 0 40 0 0 0 0 0 0 0 0 21 0 0 0 39 0 0 0 0 616 G 20 0 0 0 0 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 617 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 61 39 0 0 0 618 L 0 0 0 0 0 0 0 0 0 61 0 0 0 0 0 0 39 0 0 0 619 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 620 E 0 0 41 20 0 0 0 0 0 0 0 0 0 0 0 0 0 39 0 0 621 A 41 0 0 0 0 0 0 0 0 0 0 0 39 0 0 0 0 20 0 0 622 Q 0 0 0 0 0 0 0 0 0 0 0 21 0 79 0 0 0 0 0 0 623 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 66 0 0 0 0 624 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 625 W 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 626 P 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 67 0 0 0 0 627 R 0 0 0 0 0 0 0 0 0 0 33 0 0 0 67 0 0 0 0 0 628 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 629 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 630 F 0 0 0 0 33 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 631 C 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0