site aa pred_sec pred_expbur pred_accessibility pdb_asym_id hetero nucleotide compound metal otherpoly homo precipitant A C D E F G H I K L M N P Q R S T V W Y feature_table variant 1 M 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 2 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 3 R 0 0 0 0 0 0 34 0 0 0 0 0 0 0 66 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 4 Y 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 0 0 33 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 5 G 0 0 0 0 0 66 0 0 0 0 0 0 0 0 34 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 6 A 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 7 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 8 L 0 0 0 0 0 0 0 0 0 33 0 0 33 0 0 34 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 9 R 0 0 0 0 0 67 0 0 0 0 0 0 0 0 33 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 10 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 11 S 0 0 34 0 0 33 0 0 0 0 0 0 0 0 0 33 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 12 C 0 33 0 0 0 0 34 0 0 33 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 13 P 0 0 0 0 0 0 0 0 0 34 0 0 66 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 14 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 15 S 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 16 G 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 17 R 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66 0 0 0 34 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 18 E 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 19 Q 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 20 G 33 0 0 0 0 33 0 0 0 0 0 0 0 0 34 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 21 Q 0 0 0 0 0 0 0 0 0 34 0 0 0 33 0 33 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 22 D 0 0 66 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 23 G 0 0 0 0 0 33 0 0 0 0 0 0 0 0 67 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 24 T 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 67 33 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 25 A 33 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 SIGNAL::DISORDER:predicted by DISOPRED:SIGNAL: 26 G 0 0 0 0 0 66 0 0 0 0 0 0 34 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 27 A 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 28 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 29 G 3 1 2 2 1 69 1 2 2 3 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 30 L 3 1 2 2 1 2 1 2 2 70 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 31 L 3 1 2 2 1 2 1 2 2 70 1 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 32 W 3 1 2 2 1 2 1 2 2 3 1 1 2 1 2 2 2 2 67 1 SIGNAL::SIGNAL: 33 M 3 1 2 2 1 2 1 2 2 3 68 1 2 1 2 2 2 2 0 1 SIGNAL::SIGNAL: 34 G 5 1 4 4 3 38 1 3 4 6 2 3 3 3 3 5 4 4 1 2 SIGNAL::SIGNAL: 35 L 2 21 1 1 1 2 0 38 1 23 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 36 V 2 0 1 1 1 2 0 38 1 23 0 1 1 1 1 2 1 22 0 1 SIGNAL::SIGNAL: V->A:LB/B:rs1050228: -; 37 L 2 0 1 1 1 2 0 1 1 60 0 1 1 1 22 2 1 1 0 1 SIGNAL::SIGNAL: 38 A 22 0 1 1 1 39 0 1 1 23 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 39 L 2 0 1 1 1 2 0 38 1 44 0 1 1 1 1 2 1 1 0 1 SIGNAL::SIGNAL: 40 A 21 0 0 0 0 58 0 0 0 0 0 0 0 0 0 0 0 0 21 0 SIGNAL::SIGNAL: 41 L 0 0 0 0 0 0 0 37 0 63 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 42 A 21 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 0 37 0 0 SIGNAL::SIGNAL: 43 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 44 A 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 45 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 SIGNAL::SIGNAL: 46 A 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 58 0 0 SIGNAL::SIGNAL: 47 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 37 0 0 0 0 48 A 63 0 0 0 0 0 0 0 0 0 0 37 0 0 0 0 0 0 0 0 49 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 37 0 0 50 S 3 1 2 2 23 3 1 2 2 3 1 2 23 2 2 23 2 2 0 1 51 D 0 0 42 37 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 D->V:US:rs7485899: Niemann-Pick disease B (NPDB) ; 52 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 53 R 0 0 0 0 0 37 0 0 0 0 0 0 21 0 21 0 21 0 0 0 54 V 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 55 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 56 W 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 0 63 0 57 A 21 0 0 0 0 0 0 0 37 0 0 0 0 0 0 21 0 21 0 0 58 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 59 A 63 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 0 0 60 E 0 0 37 42 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 61 A 63 0 0 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 H 0 0 0 0 0 0 58 0 0 0 0 0 0 0 21 0 0 0 0 21 63 P 0 0 0 37 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 64 L 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 37 65 S 0 0 0 0 0 0 0 0 0 0 0 37 42 0 0 21 0 0 0 0 66 P 37 0 0 0 0 0 0 0 0 0 0 0 21 0 0 21 21 0 0 0 67 Q 0 0 0 21 0 0 0 0 0 0 0 0 0 42 37 0 0 0 0 0 68 G 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 69 H 0 0 0 0 0 0 63 0 0 0 0 37 0 0 0 0 0 0 0 0 70 P 0 0 0 37 0 0 0 0 0 0 0 0 42 0 0 21 0 0 0 0 71 A 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 72 R 0 0 0 0 0 0 0 0 79 0 0 0 0 0 21 0 0 0 0 0 73 L 0 0 0 0 42 0 0 0 0 21 37 0 0 0 0 0 0 0 0 0 74 H 0 0 0 0 0 0 21 21 0 37 0 0 0 0 0 21 0 0 0 0 75 R 21 0 0 0 0 0 0 0 0 0 0 0 0 0 79 0 0 0 0 0 76 I 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 0 37 77 V 79 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 78 P 0 0 0 0 0 0 0 0 37 0 0 0 63 0 0 0 0 0 0 0 79 R 0 0 0 0 0 0 0 0 37 0 0 0 21 21 21 0 0 0 0 0 80 L 37 0 0 0 0 0 0 0 0 63 0 0 0 0 0 0 0 0 0 0 81 R 0 0 0 0 0 0 0 37 0 0 0 0 0 42 21 0 0 0 0 0 82 D 0 0 43 15 0 0 0 0 0 0 0 27 0 0 0 15 0 0 0 0 83 V 31 0 0 27 0 0 0 0 28 0 0 0 0 0 0 0 0 15 0 0 84 F e 114.4 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 46 0 0 0 0 0 0 0 27 0 0 0 0 0 0 28 85 G e 78.6 5jg8_B NAG 0 0 0 27 0 73 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 W G e 78.1 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 28 0 0 0 0 0 0 27 0 0 0 0 0 0 46 0 87 G G e 54.8 5jg8_B 0 0 0 0 0 15 0 0 0 0 0 0 0 43 27 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 88 N G e 73.3 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 0 0 0 0 27 0 0 46 28 0 0 0 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":DOMAIN:/note="Saposin B-type":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":DOMAIN:/note="Saposin B-type" 89 L T e 55.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 0 0 80 20 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 90 T H e 30.5 5jg8_B 2 0 1 1 1 2 0 1 1 2 0 1 1 1 1 44 37 1 0 1 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 91 C H e 20.7 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->H:LP/P:-: Niemann-Pick disease B (NPDB) ; 92 P H e 56.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 31 15 0 0 0 15 0 14 0 0 25 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 93 I H e 62.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 9 0 0 15 14 0 0 23 0 0 0 0 0 0 0 15 8 16 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 94 C H b 10.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->W:LP/P:-: Niemann-Pick disease B (NPDB) ; 95 K H e 41.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 0 55 0 0 0 0 16 0 0 29 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 96 G H e 48.8 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 29 32 0 16 0 0 0 0 0 0 0 15 0 9 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 97 L H e 57.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 14 0 0 0 0 31 0 15 0 40 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 98 F H b 15.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 16 0 0 0 25 0 0 30 0 0 0 0 0 0 0 0 0 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 99 T H e 43.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 29 0 0 0 0 0 0 0 0 15 0 0 0 31 25 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 100 A H e 61.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 25 0 0 0 0 14 0 0 0 31 0 0 0 15 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 101 I H e 41.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 15 0 0 0 0 0 0 17 0 40 0 0 0 0 0 0 0 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 102 N H b 16.4 5jg8_B 0 0 8 16 0 0 0 0 0 0 0 17 0 44 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 103 L H e 50.6 5jg8_B 14 0 16 0 38 0 9 0 15 8 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 104 G H e 34.5 5jg8_B 0 0 0 15 31 25 0 0 0 14 15 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 105 L H b 16.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 0 0 0 45 0 40 0 0 0 0 0 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7512695: Niemann-Pick disease A (NPDA) ;L->P:LP/P:rs7512695: Niemann-Pick disease B (NPDB) ; 106 K T e 58.5 5jg8_B 29 0 0 0 0 15 0 0 48 0 0 0 0 0 8 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 107 K S e 54.7 5jg8_B SO4 0 0 0 15 15 0 0 0 33 0 0 8 0 14 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 108 E H e 61.3 5jg8_B 0 0 15 17 0 0 0 0 30 0 0 30 0 8 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 109 P H e 60.5 5jg8_B 24 0 0 0 0 0 0 0 15 0 0 0 17 15 0 14 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 110 N H e 34.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] SO4 0 0 0 0 0 15 0 0 0 0 0 17 0 0 0 39 29 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 111 V H b 6.0 5jg8_B 0 0 14 30 0 0 0 15 0 16 0 0 0 0 0 0 0 25 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 112 A H e 44.6 5jg8_B 25 0 0 30 0 0 0 0 0 0 0 14 15 0 0 0 16 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 113 R H e 58.5 5jg8_B 0 15 15 30 0 0 0 0 0 0 0 0 0 0 17 0 0 15 8 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 114 V H e 44.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 0 0 40 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 115 G H b 3.6 5jg8_B 14 0 0 0 0 25 0 16 0 15 15 0 0 0 0 15 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 116 S H e 44.5 5jg8_B 14 0 0 30 0 0 0 0 31 0 0 0 0 0 0 25 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 117 V H e 54.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 29 16 0 15 0 0 0 0 0 0 0 0 0 25 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 118 A H e 36.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 70 0 0 0 0 0 0 0 0 30 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 119 I H b 10.5 5jg8_B 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 16 15 29 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 120 K H e 70.8 5jg8_B 0 0 31 0 15 0 0 15 25 0 0 14 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 121 L H e 52.8 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 0 0 0 24 0 61 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 122 C H e 25.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 123 N H e 40.6 5jg8_B 0 0 14 15 0 0 0 16 24 0 0 8 0 0 0 0 15 8 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 124 L H e 69.7 5jg8_B 16 0 0 0 0 0 0 0 0 45 9 0 0 0 0 0 15 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 125 L H e 74.7 5jg8_B 0 0 0 0 44 0 0 0 0 40 0 0 0 0 0 16 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 126 K e 70.3 5jg8_B NAG 15 0 14 0 0 0 30 0 33 0 0 9 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 127 I e 89.5 5jg8_B NAG ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 16 0 0 0 55 15 0 0 0 0 0 0 0 0 14 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 128 A S b 19.6 5jg8_B 25 0 0 60 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 129 P e 34.1 5jg8_B 0 0 15 0 0 0 0 0 15 0 0 0 40 30 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 130 P H e 64.3 5jg8_B 15 0 0 0 0 0 0 0 0 9 0 15 46 0 0 0 0 0 15 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 131 A H e 59.8 5jg8_B 32 0 24 31 0 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 132 V H b 10.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" V->A:LP/P:-: Niemann-Pick disease B (NPDB) ; 133 C H b 2.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 134 Q H e 52.0 5jg8_B SO4 0 0 15 0 0 0 0 0 14 0 0 30 0 25 0 0 16 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 135 S H e 36.7 5jg8_B SO4 0 0 0 0 15 46 0 0 0 0 0 14 0 0 0 25 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 136 I H e 25.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 17 0 0 0 0 0 0 68 0 15 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 137 V H b 13.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa] 0 0 0 0 0 0 0 44 0 16 0 0 0 0 0 15 0 25 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 138 H H e 48.2 5jg8_B SO4 0 0 0 0 0 0 17 0 0 0 0 16 15 8 0 30 0 0 0 14 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 139 L H e 24.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 14 0 15 0 0 0 0 0 0 40 0 16 0 15 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7970447: Niemann-Pick disease B (NPDB) ; 140 F H b 19.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 141 E H b 15.1 5jg8_B 15 0 0 25 0 0 0 0 14 0 0 0 0 0 15 15 0 16 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 142 D H e 40.7 5jg8_B SO4 0 0 69 0 0 0 0 0 0 0 0 15 16 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 143 D H b 18.5 5jg8_B 0 0 25 44 0 0 0 16 0 0 15 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 144 M H e 24.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 30 0 0 16 0 0 17 0 0 0 0 0 15 22 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 145 V H b 16.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 15 0 0 0 0 0 15 0 0 0 0 0 0 55 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 146 E H e 20.1 5jg8_B 0 0 16 25 14 0 0 0 0 0 0 15 0 0 0 0 0 0 0 30 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 147 V H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 148 W H e 47.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 15 0 0 15 0 45 0 0 0 0 0 0 0 0 25 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 149 R H b 9.9 5jg8_B 0 0 0 14 0 0 0 16 15 0 0 0 0 0 23 15 17 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 150 R H e 36.0 5jg8_B SO4 0 0 0 0 0 0 0 0 0 0 0 0 0 31 54 0 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 151 S T b 2.3 5jg8_B 15 0 0 0 0 0 0 15 0 0 0 0 15 0 0 55 0 0 0 0 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD.":DOMAIN:/note="Saposin B-type":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on subcellular location. No effect on phosphorylation by PRKCD.":DOMAIN:/note="Saposin B-type" 152 V T b 19.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 16 0 0 0 0 0 0 15 0 15 0 0 0 0 15 39 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 153 L S e 22.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 15 30 0 0 0 0 25 0 0 0 0 0 0 0 30 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 154 S S e 21.9 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 40 60 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 155 P T e 27.1 5jg8_B 0 0 0 0 0 15 0 0 0 0 0 0 85 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 156 S T b 18.0 5jg8_B 0 0 0 29 0 0 15 0 0 0 0 0 0 0 0 56 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 157 E T b 8.5 5jg8_B 0 0 0 39 0 0 0 0 0 0 0 0 0 46 0 0 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 158 A H b 7.1 5jg8_B 25 0 0 0 0 0 0 29 0 31 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 159 C H b 0.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" C->R:LP/P:rs7275041: Niemann-Pick disease B (NPDB) ; 160 G H b 9.5 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 161 L H e 56.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 14 0 0 0 15 0 0 15 0 40 0 0 0 0 0 0 0 0 0 16 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 162 L H e 64.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa]:Sphingomyelin phosphodiesterase[529 aa] 0 0 0 0 30 0 0 15 0 40 0 0 0 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 163 L T e 46.1 5jg8_B 1 0 1 1 1 1 0 31 1 42 15 1 1 1 1 1 1 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" L->P:LP/P:rs7801344: Niemann-Pick disease B (NPDB) ; 164 G B b 17.9 5jg8_B 15 16 1 1 1 26 0 1 16 1 0 1 16 1 1 1 1 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 165 S T e 89.8 5jg8_B 0 0 15 0 0 15 0 0 0 0 0 29 0 0 0 41 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 166 T T e 92.9 5jg8_B 17 15 16 1 16 1 0 1 1 1 0 1 1 1 1 18 9 1 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 167 C B b 1.3 5jg8_B 15 69 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 0 DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type":DISULFID:ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DOMAIN:/note="Saposin B-type" 168 G b 17.9 5jg8_B 0 0 15 0 0 70 0 0 0 0 0 0 15 0 0 0 0 0 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" G->R:LP/P:rs1847910: Niemann-Pick disease B (NPDB) ; 169 H e 68.6 5jg8_B 0 0 15 0 0 0 39 0 0 0 0 0 15 0 0 16 0 0 0 15 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 170 W e 37.8 5jg8_B 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 30 15 15 25 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 171 D e 35.8 5jg8_B NAG beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 54 0 0 0 0 0 0 0 0 16 15 0 0 0 0 15 0 0 DOMAIN:/note="Saposin B-type":DOMAIN:/note="Saposin B-type" 172 I T b 12.9 5jg8_B 0 0 0 16 0 0 0 25 0 29 0 0 0 0 15 15 0 0 0 0 173 F T e 46.4 5jg8_B 15 0 0 15 25 0 0 0 0 0 0 15 0 0 0 0 14 0 0 16 174 S e 34.4 5jg8_B SO4 0 0 0 0 0 0 14 0 0 0 0 0 0 0 16 55 15 0 0 0 175 S e 70.3 5jg8_B NAG SO4 0 0 0 0 0 15 0 15 0 0 14 0 0 16 0 32 9 0 0 0 176 W b 9.6 5jg8_B NAG 1 0 1 17 1 1 0 1 1 1 0 1 1 1 1 1 1 1 69 0 177 N e 74.5 5jg8_B NAG beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 0 0 0 0 0 0 0 0 0 0 15 69 0 0 0 16 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces protein levels. Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." 178 I b 5.3 5jg8_B beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 0 0 0 0 13 0 0 45 0 15 13 0 0 0 0 0 0 13 0 0 I->N:LP/P:rs7497807: Niemann-Pick disease B (NPDB) ; 179 S e 60.2 5jg8_B beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 11 0 0 0 0 13 0 10 0 0 0 12 0 0 0 33 21 0 0 0 180 L e 22.5 5jg8_B 0 0 0 0 0 0 0 21 12 57 0 10 0 0 0 0 0 0 0 0 181 P e 34.9 5jg8_B 0 0 0 0 10 15 0 0 0 0 0 0 75 0 0 0 0 0 0 0 182 T S e 94.2 5jg8_B 6 0 0 0 0 21 0 0 0 15 0 0 21 0 0 6 17 13 0 0 183 V S e 38.0 5jg8_B 15 0 1 1 1 2 0 1 22 2 12 1 1 1 1 1 16 19 0 1 184 P e 84.5 5jg8_B 0 0 0 0 0 9 0 0 10 0 0 10 70 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 185 K e 35.8 5jg8_B 12 0 0 0 0 0 0 0 67 0 0 11 0 10 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 186 P e 34.1 5jg8_B 0 0 0 0 0 12 0 0 0 0 0 0 67 11 10 0 0 0 0 0 DISORDER:predicted by DISOPRED P->L:LP/P:rs1057517: Niemann-Pick disease A (NPDA) ; 187 P e 86.0 5jg8_B 0 0 0 0 0 12 0 0 12 0 0 0 56 10 0 0 10 0 0 0 DISORDER:predicted by DISOPRED 188 P e 60.5 5jg8_B 0 0 0 0 10 0 9 9 0 12 0 0 16 0 12 10 0 11 0 10 DISORDER:predicted by DISOPRED 189 K e 59.4 5jg8_B SO4 0 0 0 0 0 0 0 0 63 0 0 12 0 6 0 0 0 19 0 0 DISORDER:predicted by DISOPRED 190 P e 64.3 5jg8_B 0 0 10 0 0 0 0 21 10 0 0 0 59 0 0 0 0 0 0 0 DISORDER:predicted by DISOPRED 191 P e 44.2 5jg8_B 0 0 0 0 0 0 0 0 18 16 0 0 38 0 0 0 10 10 8 0 DISORDER:predicted by DISOPRED 192 S e 65.6 5jg8_B SO4 7 0 10 0 0 0 0 0 16 11 0 0 9 9 0 19 0 17 0 0 DISORDER:predicted by DISOPRED 193 P e 90.7 5jg8_B 19 0 0 0 0 11 0 10 9 0 0 9 21 9 0 0 0 9 0 0 DISORDER:predicted by DISOPRED 194 P e 39.5 5jg8_B 7 0 0 0 0 20 0 8 9 0 0 0 38 9 0 0 0 9 0 0 DISORDER:predicted by DISOPRED 195 A e 58.0 5jg8_B 27 0 9 8 0 14 0 0 8 0 0 0 15 0 0 17 0 0 0 0 DISORDER:predicted by DISOPRED 196 P T e 104.7 5jg8_B 0 0 12 9 0 0 0 5 19 0 0 0 44 0 0 0 6 0 0 5 DISORDER:predicted by DISOPRED 197 G T e 106.0 5jg8_B 0 0 0 8 0 51 0 0 0 0 0 28 0 8 4 0 0 0 0 0 198 A e 25.0 5jg8_B 25 0 8 0 0 0 0 0 25 0 8 8 6 0 0 11 0 9 0 0 A->P:LP/P:rs7970447: Niemann-Pick disease B (NPDB) ; 199 P e 51.2 5jg8_B 6 0 0 0 0 0 0 0 0 9 0 0 51 8 0 23 0 0 0 0 200 V E e 48.7 5jg8_B 0 0 0 0 0 0 8 16 0 8 8 0 0 0 0 0 21 36 0 0 201 S E b 1.6 5jg8_B 0 0 0 0 7 48 0 0 8 8 6 0 0 0 0 20 0 0 0 0 202 R E b 19.0 5jg8_B 0 0 0 0 0 0 0 0 18 0 0 0 0 21 55 0 0 0 0 6 R->C:LP/P:rs7495952: Niemann-Pick disease B (NPDB) ; 203 I E b 1.2 5jg8_B 7 0 0 0 61 0 0 15 0 0 0 0 0 0 0 0 0 18 0 0 204 L E b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 22 0 205 F E b 0.5 5jg8_B 0 0 0 0 10 0 78 0 0 0 0 0 0 12 0 0 0 0 0 0 206 L E b 1.1 5jg8_B 0 0 0 0 0 0 0 61 0 26 0 0 0 0 0 0 0 14 0 0 207 T b 1.9 5jg8_B 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 76 0 0 0 208 D b 0.0 5jg8_B PC ZN ACT 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 209 L b 3.9 5jg8_B 0 0 0 0 4 0 0 20 0 45 20 0 0 0 0 0 5 5 0 0 210 H b 0.0 5jg8_B PC ZN ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 211 W B b 6.8 5jg8_B 0 0 0 0 5 0 0 5 0 22 0 0 36 0 0 0 0 16 9 5 W->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 212 D b 3.1 5jg8_B 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 213 H S e 42.4 5jg8_B 0 0 0 4 11 0 14 7 5 5 6 0 43 6 0 0 0 0 0 0 214 D e 25.9 5jg8_B 0 0 16 9 12 0 0 0 0 5 5 4 0 5 0 0 14 5 0 25 215 Y B b 5.7 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 216 L e 24.7 5jg8_B 1 0 1 12 0 1 4 6 31 10 0 0 1 0 0 1 11 20 0 0 L->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 217 E T e 39.7 5jg8_B 4 0 0 29 0 0 10 4 7 0 0 0 6 0 0 5 5 25 0 6 218 G T e 41.7 5jg8_B 0 0 0 0 0 61 6 10 0 0 0 5 6 0 0 9 4 0 0 0 219 T S b 3.9 5jg8_B 5 0 0 0 0 10 0 0 9 6 5 0 0 0 0 34 33 0 0 0 220 D b 8.6 5jg8_B 1 0 42 18 1 1 0 1 1 1 0 11 1 1 1 17 1 1 0 0 221 P S b 4.7 5jg8_B 24 1 2 7 1 2 1 11 2 3 1 1 24 1 1 2 8 7 0 1 222 D S e 46.9 5jg8_B 7 0 41 1 5 6 0 1 1 6 0 15 1 1 1 1 1 1 0 9 223 C b 13.3 5jg8_B 0 36 5 7 0 6 7 0 6 0 0 0 0 9 3 14 7 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 224 A S e 63.4 5jg8_B 19 0 6 4 1 17 0 10 1 1 0 1 1 6 1 1 16 16 0 0 225 D S e 24.7 5jg8_B 2 9 34 6 1 1 5 1 11 2 0 4 1 1 6 1 7 1 0 6 MUTAGEN:/note="D->A: Does not affect cleavage by CASP7.":MUTAGEN:/note="D->A: Does not affect cleavage by CASP7." 226 P S e 34.9 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa]:Sphingomyelin phosphodiesterase[530 aa] 12 1 1 2 1 2 7 1 2 2 1 5 41 1 1 2 6 11 0 1 227 L S b 0.0 5jg8_B 3 10 2 2 1 3 1 2 6 22 6 2 2 7 2 2 2 17 0 8 L->M:LP/P:-: Niemann-Pick disease B (NPDB) ;L->P:LP/P:rs7643179: Niemann-Pick disease B (NPDB) ; 228 C b 0.0 5jg8_B 17 52 1 1 1 1 0 1 1 6 0 1 1 1 1 1 6 5 0 1 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:rs1564923: Niemann-Pick disease A (NPDA) ; 229 C S b 0.0 5jg8_B 1 67 1 1 1 1 0 1 1 2 0 1 1 1 1 11 1 1 0 7 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 230 R B b 2.4 5jg8_B 5 0 8 1 1 1 21 1 1 2 0 1 1 1 42 11 1 1 0 1 R->C:LP/P:rs9896392: Niemann-Pick disease A (NPDA) ;R->C:LP/P:rs9896392: Niemann-Pick disease B (NPDB) ;R->H:LP/P:rs1413877: Niemann-Pick disease A (NPDA) ; 231 R T e 65.2 5jg8_B 6 0 12 7 1 7 7 1 11 2 0 1 7 1 21 10 1 7 0 1 232 G T e 92.9 5jg8_B 0 0 8 0 0 37 9 0 0 0 0 7 5 6 0 18 0 5 0 5 233 S S b 10.9 5jg8_B 18 0 6 0 0 0 0 0 20 0 0 5 5 0 0 25 10 11 0 0 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD.":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." 234 G e 54.8 5jg8_B 6 0 7 0 0 57 0 0 0 0 6 10 0 0 0 6 0 0 0 6 G->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 235 L e 78.7 5jg8_B 8 1 9 12 1 3 1 2 12 6 1 8 5 2 7 11 2 6 4 1 236 P e 20.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 6 0 7 2 1 2 1 1 1 2 1 1 39 10 1 7 8 8 0 1 237 P e 63.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 7 1 1 12 1 7 1 1 12 2 1 1 25 1 1 11 11 2 0 1 238 A T e 98.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 23 0 1 1 1 2 0 7 10 8 0 14 1 1 1 7 1 15 0 6 239 S T e 90.6 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 2 0 11 7 1 22 0 1 6 11 0 1 1 1 1 24 1 7 0 1 240 R e 32.4 5jg8_B 2 0 5 12 1 6 0 1 38 2 0 11 1 7 9 1 1 1 0 1 241 P e 76.7 5jg8_B 1 0 17 1 1 6 0 1 13 1 0 6 38 1 1 7 1 1 0 4 242 G e 33.3 5jg8_B 15 0 4 0 0 34 0 0 15 0 0 4 0 0 8 5 7 5 0 0 243 A b 8.0 5jg8_B 67 0 4 0 0 5 0 0 0 0 0 7 11 0 0 0 0 5 0 0 A->V:LP/P:rs1291958: Niemann-Pick disease A (NPDA) ; 244 G b 13.1 5jg8_B 12 0 1 1 0 64 0 1 1 1 0 1 5 0 1 5 1 6 0 0 G->R:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 245 Y T e 50.0 5jg8_B 1 0 1 5 3 1 0 1 12 8 0 1 23 0 9 5 1 4 0 25 246 W T b 16.3 5jg8_B 0 0 0 0 27 5 0 9 0 9 0 0 0 0 0 0 0 0 38 11 W->C:LP/P:-: Niemann-Pick disease B (NPDB) ; 247 G b 0.0 5jg8_B 5 0 0 0 0 95 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->S:LP/P:rs5877794: Niemann-Pick disease A (NPDA) ;G->S:LP/P:rs5877794: Niemann-Pick disease B (NPDB) ;G->D:LP/P:rs1590739: Niemann-Pick disease A (NPDA) ; 248 E b 18.6 5jg8_B 0 0 23 13 0 0 13 0 4 0 5 12 6 0 7 11 4 0 0 0 E->Q:LP/P:rs2007634: Niemann-Pick disease B (NPDB) ;E->K:LP/P:rs2007634: Niemann-Pick disease A (NPDA) ; 249 Y S b 13.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 5 0 1 1 0 6 0 0 1 5 12 0 5 0 0 1 1 26 0 36 250 S S e 29.7 5jg8_B 2 1 2 2 1 24 1 2 2 3 5 1 2 1 2 31 2 8 0 11 MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD.":MUTAGEN:/note="S->A: No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. No effect on phosphorylation by PRKCD." S->R:LP/P:rs7507798: Niemann-Pick disease A (NPDA) ;S->R:LP/P:rs7507798: Niemann-Pick disease B (NPDB) ; 251 K S e 25.5 5jg8_B 1 0 10 6 0 13 0 1 22 30 3 0 1 0 1 10 1 1 0 0 252 C b 0.0 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 253 D b 0.0 5jg8_B 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 MUTAGEN:/note="D->A: Abolished cleavage by CASP7.":SITE:/note="Cleavage; by CASP7":MUTAGEN:/note="D->A: Abolished cleavage by CASP7.":SITE:/note="Cleavage; by CASP7" D->E:LP/P:-: Niemann-Pick disease A (NPDA) ;D->H:LP/P:rs3981234: Niemann-Pick disease A (NPDA) ; 254 L B b 0.0 5jg8_B 4 4 0 0 0 8 0 14 0 18 0 0 0 0 0 35 17 0 0 0 SITE:/note="Cleavage; by CASP7":SITE:/note="Cleavage; by CASP7" 255 P b 4.7 5jg8_B 0 0 0 0 0 0 0 5 0 0 0 11 79 0 0 5 0 0 0 0 P->S:LP/P:-: Niemann-Pick disease A (NPDA) ; 256 L H e 35.4 5jg8_B 0 0 5 0 20 0 0 4 0 8 20 0 0 7 0 0 0 4 7 25 257 R H e 20.2 5jg8_B 13 0 4 5 0 0 0 4 9 10 0 0 0 13 11 13 0 4 10 4 258 T H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 64 4 0 0 0 0 0 32 0 0 0 T->I:LP/P:-: Niemann-Pick disease B (NPDB) ; 259 L H b 1.7 5jg8_B 0 0 0 0 5 0 0 24 0 34 19 0 0 0 0 0 0 18 0 0 260 E H e 54.8 5jg8_B 0 0 7 39 3 0 0 0 0 8 0 25 0 5 0 7 5 0 0 0 261 S H b 14.8 5jg8_B 9 0 4 11 0 0 0 4 0 5 3 10 0 0 0 40 0 0 9 4 262 L H b 2.2 5jg8_B 16 0 0 0 0 0 0 9 0 13 14 0 0 0 0 12 29 7 0 0 263 L H b 5.6 5jg8_B 0 0 0 0 35 0 4 10 5 40 5 0 0 0 0 0 0 0 0 0 264 S H e 63.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 4 0 28 14 0 0 0 0 15 0 0 0 0 10 4 17 0 0 0 7 265 G T e 34.5 5jg8_B 7 0 0 7 15 8 20 0 0 0 0 9 0 0 0 0 0 0 29 5 266 L T b 7.3 5jg8_B 0 0 0 0 0 0 0 47 0 21 19 0 0 5 0 0 0 8 0 0 267 G S e 66.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 20 0 17 0 0 8 0 0 31 7 0 5 0 0 0 5 0 5 0 0 268 P S e 78.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 6 0 6 20 0 0 0 0 18 0 0 19 8 8 0 6 10 0 0 0 269 A S e 32.1 5jg8_B 17 0 0 0 0 4 5 7 12 0 0 8 0 0 4 15 15 12 0 0 270 G b 10.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 34 16 0 30 5 0 5 0 0 11 0 0 0 0 0 0 0 0 271 P e 82.2 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 14 29 0 5 0 0 16 0 5 0 15 8 0 7 0 0 0 0 272 F b 12.4 5jg8_B 8 0 0 4 8 0 0 43 8 15 0 7 0 0 0 0 0 7 0 0 273 D S e 45.1 5jg8_B SO4 0 0 86 3 0 0 0 0 0 0 0 0 0 0 0 11 0 0 0 0 274 M E b 4.8 5jg8_B 0 0 0 0 73 0 0 4 0 0 13 0 0 0 0 0 0 0 0 10 275 V E b 0.0 5jg8_B 0 0 0 0 0 0 0 47 0 0 11 0 0 0 0 0 0 42 0 0 276 Y E b 0.0 5jg8_B 0 0 0 0 4 0 0 50 0 13 5 0 0 0 0 0 0 21 0 8 277 W E b 0.8 5jg8_B 0 0 0 0 0 0 0 5 0 0 5 0 0 0 0 0 0 5 78 7 278 T b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 95 0 0 0 279 G b 2.4 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 280 D b 0.6 5jg8_B PC ZN ACT 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" D->A:LP/P:-: Niemann-Pick disease A (NPDA) ; 281 I b 1.2 5jg8_B 0 0 12 0 5 7 0 8 0 5 0 42 0 0 0 11 5 0 0 5 282 P B b 3.1 5jg8_B 21 0 0 5 0 0 0 13 0 0 0 0 33 0 0 5 7 17 0 0 P->F:LP/P:-: Niemann-Pick disease B (NPDB) ; 283 A b 3.6 5jg8_B 12 0 0 0 0 7 0 0 0 0 0 5 32 0 38 5 0 0 0 0 A->T:LP/P:rs7521485: Niemann-Pick disease B (NPDB) ; 284 H S b 11.0 5jg8_B PC ZN ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 285 D b 9.3 5jg8_B 0 0 52 0 0 7 0 0 0 5 0 8 0 0 0 0 5 24 0 0 286 V b 17.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 5 0 0 5 0 15 0 7 0 13 13 0 8 10 3 21 0 0 287 W S b 9.6 5jg8_B 0 0 22 0 0 0 0 0 4 4 0 8 3 0 3 0 0 6 38 11 288 H S e 40.8 5jg8_B 5 0 5 32 0 0 11 0 0 3 0 5 14 5 8 11 0 0 0 0 289 Q b 3.1 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 13 0 5 5 0 4 6 4 0 4 21 19 4 0 0 0 15 290 T e 39.0 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 0 5 0 0 4 0 22 0 4 0 0 4 28 27 5 0 0 291 R H e 27.3 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 4 0 0 19 0 7 0 5 0 0 0 5 20 12 8 6 10 0 0 4 R->H:US:rs1803161: Niemann-Pick disease B (NPDB) ; 292 Q H e 78.6 5jg8_B 5 0 12 27 0 6 0 0 0 1 0 0 0 20 15 4 6 0 0 0 293 D H e 24.1 5jg8_B 12 0 22 9 0 1 0 0 0 5 0 9 0 9 0 7 23 0 0 0 294 Q H b 4.6 5jg8_B 13 0 0 0 0 1 10 15 4 1 0 0 5 31 0 0 8 11 0 0 Q->K:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 295 L H e 27.5 5jg8_B 1 0 6 5 19 1 0 17 5 22 0 0 0 0 5 11 0 7 0 0 296 R H e 33.2 5jg8_B 1 0 8 21 10 4 0 3 3 9 0 7 0 10 11 6 0 0 0 5 R->Q:LB/B:rs3582445: -; 297 A H b 5.4 5jg8_B 21 0 4 5 0 1 0 14 0 1 16 8 0 0 0 5 0 19 0 4 298 L H b 1.7 5jg8_B 1 0 0 0 5 1 0 17 0 29 9 15 0 0 0 4 5 12 0 0 299 T H e 45.5 5jg8_B 14 0 5 4 5 6 0 0 6 1 0 9 0 12 9 0 24 4 0 0 300 T H e 32.5 5jg8_B 1 0 0 8 0 1 0 4 5 5 0 30 0 9 8 10 18 0 0 0 301 V H b 0.7 5jg8_B 1 0 0 0 0 1 0 13 0 23 18 15 0 5 0 0 0 22 0 0 302 T H b 2.6 5jg8_B 8 0 0 5 0 0 5 0 0 0 0 0 0 4 10 23 40 4 0 0 303 A H e 52.7 5jg8_B 9 0 13 11 0 0 0 0 4 0 7 17 0 5 9 4 13 3 5 0 304 L H b 14.0 5jg8_B 0 0 4 0 0 0 0 10 7 48 4 0 0 0 0 0 17 10 0 0 L->P:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 305 V H b 0.0 5jg8_B 12 0 0 0 12 4 0 31 0 0 4 0 0 0 0 0 4 32 0 0 306 R H e 50.6 5jg8_B 0 0 14 4 0 0 4 0 25 8 0 5 0 21 14 0 0 0 0 4 307 K H e 70.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 19 0 5 0 0 35 4 0 11 0 0 7 15 4 0 0 0 308 F H e 32.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 15 0 0 0 0 22 19 0 0 0 0 0 18 7 0 18 309 L H b 9.6 5jg8_B 5 0 0 0 59 0 0 5 0 12 0 0 0 4 3 4 0 0 0 7 310 G T e 36.9 5jg8_B 4 0 4 11 0 23 0 0 8 0 0 0 43 0 4 0 3 0 0 0 311 P T e 103.1 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 7 0 26 6 0 5 0 0 13 0 0 17 11 0 0 9 0 4 0 0 312 V S e 22.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 0 0 0 17 0 11 4 0 0 0 0 0 27 33 0 7 313 P e 31.8 5jg8_B 0 0 0 0 0 0 0 0 15 0 0 0 69 11 0 4 0 0 0 0 314 V E b 0.0 5jg8_B 0 0 0 0 7 0 0 32 0 4 0 0 0 0 0 0 0 57 0 0 V->M:LP/P:rs1228068: Niemann-Pick disease B (NPDB) ; 315 Y E b 6.5 5jg8_B 0 0 0 0 20 0 0 19 0 5 0 0 0 0 0 0 0 26 0 30 Y->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 316 P E b 0.8 5jg8_B 7 0 0 0 5 0 0 0 0 0 0 0 72 0 0 5 0 5 5 0 317 A b 1.8 5jg8_B 46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 42 12 0 0 0 318 V b 0.7 5jg8_B 0 0 0 0 0 0 0 33 0 54 0 0 0 0 0 0 0 13 0 0 V->E:LB/B:rs1257513: -; 319 G b 0.0 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->R:LP/P:rs7579347: Niemann-Pick disease A (NPDA) ; 320 N S b 1.2 5jg8_B PC ZN ACT 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" N->D:US:rs7799276: Niemann-Pick disease B (NPDB) ; 321 H S b 9.9 5jg8_B PC ACT 0 0 0 0 0 0 55 0 0 0 0 45 0 0 0 0 0 0 0 0 H->Y:LP/P:-: Niemann-Pick disease A (NPDA) ; 322 E S b 2.5 5jg8_B 0 0 68 32 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 323 S S b 1.6 5jg8_B 5 0 0 0 7 15 0 15 0 0 0 0 0 0 0 16 0 30 0 11 324 T S b 7.8 5jg8_B 1 0 0 0 24 1 7 0 0 10 0 0 0 0 0 0 8 15 12 19 T->I:LB/B:rs1050233: -;T->P:US:-: Niemann-Pick disease A (NPDA) ; 325 P S b 1.6 5jg8_B 1 0 0 0 0 1 0 0 0 1 0 0 94 0 0 0 0 0 0 0 P->A:LP/P:rs7613082: Niemann-Pick disease B (NPDB) ; 326 V T b 10.7 5jg8_B 5 0 0 0 0 1 38 0 8 1 0 0 0 21 0 0 0 22 0 0 327 N T b 7.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 1 0 27 0 0 1 5 0 0 1 0 63 0 0 0 0 0 0 0 0 328 S b 2.3 5jg8_B 6 0 1 1 1 6 0 6 1 16 9 6 1 29 1 13 1 1 0 1 329 F b 0.0 5jg8_B 1 0 1 1 51 1 0 10 1 18 5 0 1 0 0 1 1 1 0 9 330 P b 2.3 5jg8_B 20 0 1 1 1 9 0 1 1 7 0 1 38 1 1 12 1 6 0 0 331 P b 0.8 5jg8_B 8 0 8 1 1 9 0 6 1 6 0 1 44 1 1 1 1 11 0 0 332 P T e 38.8 5jg8_B 3 1 2 3 2 3 16 2 2 4 1 2 34 2 2 7 2 3 1 8 P->R:LP/P:rs2020819: Niemann-Pick disease B (NPDB) ; 333 F T e 41.6 5jg8_B SO4 4 1 2 3 19 3 1 8 3 4 1 9 2 2 2 8 22 3 1 1 334 I S b 2.9 5jg8_B SO4 4 1 2 3 2 3 1 10 3 19 11 2 2 2 2 10 8 12 1 1 335 E e 77.4 5jg8_B SO4 4 1 7 11 2 3 1 2 8 8 1 2 8 24 2 3 3 3 1 6 336 G S e 46.4 5jg8_B 14 8 8 9 2 17 1 3 8 5 1 2 3 2 3 4 3 4 1 2 337 N S e 75.8 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 8 1 3 3 2 9 1 3 8 5 1 17 8 2 8 8 8 3 1 2 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: No effect on sphingomyelin phosphodiesterase activity. No effect on secretion." 338 H S e 31.9 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a.. SO4 4 1 9 3 7 8 4 2 3 9 1 7 8 11 7 3 3 3 1 7 339 S S b 7.0 5jg8_B 4 0 1 1 1 22 6 1 1 1 0 6 5 4 1 30 1 10 5 0 340 S S b 3.1 5jg8_B 0 0 0 0 0 0 0 0 0 0 5 10 19 0 4 34 24 0 0 0 341 R H e 48.6 5jg8_B 1 0 6 1 0 1 3 1 1 1 0 12 1 19 26 16 10 1 0 0 342 W H b 12.7 5jg8_B 1 0 1 16 7 1 0 1 12 6 0 4 1 1 4 1 1 1 42 0 343 L H b 1.1 5jg8_B 0 0 0 0 0 0 0 16 0 52 10 0 0 0 0 0 0 12 0 8 L->P:LP/P:-: Niemann-Pick disease A (NPDA) ;L->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 344 Y H b 2.2 5jg8_B 1 0 0 1 13 1 0 0 1 6 0 0 0 0 0 1 15 1 0 60 345 E H e 45.7 5jg8_B 1 0 10 24 1 1 0 1 16 1 0 18 1 6 11 7 1 1 0 0 346 A H b 17.0 5jg8_B 30 0 1 10 1 1 6 9 1 1 0 5 1 18 1 6 8 1 0 0 347 M T b 0.0 5jg8_B 2 0 1 1 10 2 0 10 1 16 22 1 1 1 1 2 1 21 0 6 348 A T b 3.6 5jg8_B 35 0 1 1 1 2 0 1 1 10 0 1 1 10 1 18 7 1 0 6 349 K T e 78.8 5jg8_B 1 0 6 15 0 6 6 1 9 5 0 12 1 9 12 1 11 1 0 4 350 A S b 19.6 5jg8_B 19 0 5 1 0 1 0 26 1 28 10 0 1 0 1 1 1 1 0 5 351 W S b 0.8 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 95 0 352 E T e 55.8 5jg8_B 16 0 5 8 0 8 4 0 23 0 0 0 0 5 9 21 0 0 0 0 353 P T e 41.1 5jg8_B 5 0 11 4 0 5 9 0 4 0 0 4 41 11 5 0 0 0 0 0 354 W T b 10.8 5jg8_B 0 0 0 0 37 0 0 0 0 5 0 0 0 0 0 0 0 0 57 0 355 L S b 3.4 5jg8_B 0 0 0 0 0 0 0 38 0 41 0 0 0 0 0 0 0 21 0 0 356 P e 48.8 5jg8_B 0 0 11 0 0 3 0 0 0 0 0 4 63 0 0 17 3 0 0 0 357 A H e 61.6 5jg8_B 22 0 0 33 0 0 0 0 0 0 0 12 4 9 0 4 7 4 0 5 358 E H e 62.8 5jg8_B 17 0 21 47 0 5 0 0 0 0 0 7 0 4 0 0 0 0 0 0 359 A H b 0.0 5jg8_B 38 0 0 5 0 0 0 0 0 0 0 0 0 45 0 12 0 0 0 0 A->D:LP/P:rs7970448: Niemann-Pick disease B (NPDB) ; 360 L H b 7.3 5jg8_B 4 0 0 5 0 0 0 20 5 21 0 0 0 15 15 0 0 11 0 4 361 R H e 58.5 5jg8_B 11 0 10 9 0 0 25 0 5 0 0 4 0 4 13 15 3 0 0 0 362 T H b 14.3 5jg8_B 4 0 0 0 0 0 0 8 0 12 3 4 0 0 0 22 42 4 0 0 363 L H b 0.0 5jg8_B 0 0 0 0 57 0 0 0 0 34 0 0 0 0 0 0 0 10 0 0 L->R:US:-: Niemann-Pick disease A (NPDA) ; 364 R H e 41.5 5jg8_B 0 0 11 19 0 0 0 0 20 12 0 4 0 14 16 4 0 0 0 0 365 I H e 51.5 5jg8_B 0 0 0 5 5 0 4 8 25 5 0 0 0 0 27 0 0 0 0 21 366 G T b 1.2 5jg8_B 0 0 8 0 0 58 0 0 0 0 0 5 0 0 21 4 0 0 0 4 367 G S b 0.0 5jg8_B 31 0 0 0 0 55 0 0 0 0 0 0 0 0 0 9 4 0 0 0 368 F b 6.2 5jg8_B 0 5 0 0 27 0 0 0 0 0 0 0 0 0 0 32 0 0 5 31 369 Y E b 0.4 5jg8_B 0 0 0 0 36 0 0 0 0 0 0 0 0 0 0 0 0 0 0 64 Y->C:LP/P:rs3722878: Niemann-Pick disease A (NPDA) ; 370 A E b 7.1 5jg8_B 12 4 0 0 19 0 0 0 0 10 5 0 0 0 0 21 17 7 0 5 371 L E b 5.1 5jg8_B 0 5 0 12 0 0 0 0 9 12 0 0 0 4 0 5 13 41 0 0 372 S e 50.8 5jg8_B 6 0 5 33 0 0 0 0 13 9 0 0 4 5 0 15 5 0 0 5 373 P S b 16.3 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 4 0 0 0 0 0 0 14 0 0 0 3 27 0 0 6 3 44 0 0 P->S:LP/P:rs1342372: Niemann-Pick disease B (NPDB) ; 374 Y S b 7.4 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 0 0 0 0 0 0 0 38 10 0 5 11 0 4 5 12 0 7 0 8 375 P T e 79.1 5jg8_B NAG 0 0 10 5 0 4 0 0 0 0 0 0 63 0 4 11 4 0 0 0 376 G T e 44.0 5jg8_B 7 0 17 0 0 61 0 0 3 0 0 12 0 0 0 0 0 0 0 0 377 L E b 0.6 5jg8_B 0 0 0 0 5 7 0 0 0 88 0 0 0 0 0 0 0 0 0 0 378 R E b 13.0 5jg8_B 38 0 0 0 0 0 0 0 10 0 0 0 0 0 45 0 7 0 0 0 R->H:LP/P:rs5590880: Niemann-Pick disease B (NPDB) ;R->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 379 L E b 0.0 5jg8_B 5 0 0 0 0 0 0 32 0 17 5 0 0 0 0 0 0 40 0 0 380 I E b 0.0 5jg8_B 0 0 0 0 5 0 0 71 0 11 5 0 0 0 0 0 0 7 0 0 381 S E b 0.8 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 88 5 7 0 0 S->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 382 L b 0.0 5jg8_B 0 0 0 0 8 0 0 13 0 79 0 0 0 0 0 0 0 0 0 0 383 N b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 384 M G b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 12 5 0 0 0 0 83 0 0 0 M->I:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ;M->I:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 385 N G b 0.0 5jg8_B 0 0 0 0 0 5 0 11 0 43 0 31 0 0 0 0 0 10 0 0 N->S:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ; 386 F G b 0.0 5jg8_B 0 0 0 5 22 0 0 0 0 26 0 0 0 0 0 0 0 0 4 44 387 C G b 0.0 5jg8_B 0 21 0 0 14 5 0 0 0 17 4 5 0 0 0 0 0 0 4 30 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 388 S b 1.6 5jg8_B 0 0 10 5 25 0 0 0 0 0 0 4 0 0 0 25 0 0 0 31 389 R S e 47.4 5jg8_B 0 0 10 5 0 11 0 0 20 0 5 14 0 4 13 4 4 12 0 0 390 E S e 59.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] 12 0 0 12 5 8 0 10 12 0 0 4 11 0 5 16 5 0 0 0 391 N b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 N->T:LP/P:-: Niemann-Pick disease A (NPDA) ;N->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 392 F G b 11.5 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[530 aa] 16 0 1 1 28 2 0 9 8 6 0 1 9 1 6 2 6 1 0 1 393 W G b 0.0 5jg8_B 8 1 1 6 6 7 1 1 2 7 5 8 5 6 1 5 2 2 13 14 W->G:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ;W->R:LP/P:-: Niemann-Pick disease A (NPDA) ; 394 L G b 0.6 5jg8_B 0 5 0 0 0 0 0 0 0 38 8 5 11 4 0 4 12 13 0 0 395 L G b 17.4 5jg8_B 4 9 5 0 7 0 0 0 0 29 0 0 0 0 4 0 19 8 0 15 396 I T b 18.1 5jg8_B 13 0 22 4 0 0 0 13 0 22 0 0 0 0 0 7 0 16 0 0 397 N e 45.5 5jg8_B NAG beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-..:2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 20 4 0 4 4 0 0 0 0 51 5 0 0 5 7 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Reduces sphingomyelin phosphodiesterase activity. No effect on secretion." 398 S b 7.0 5jg8_B 0 4 0 5 0 0 0 0 16 5 7 17 12 13 0 16 5 0 0 0 399 T S e 37.0 5jg8_B beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 7 11 0 0 0 0 0 0 9 5 0 9 0 7 0 10 37 5 0 0 400 D S b 9.9 5jg8_B 0 0 82 5 0 5 0 0 0 0 0 4 0 0 0 4 0 0 0 0 401 P G b 3.9 5jg8_B 0 0 0 5 0 0 0 0 4 0 0 4 79 0 0 7 0 0 0 0 402 A G e 31.2 5jg8_B 32 7 15 0 0 24 0 0 8 0 0 5 5 0 3 0 0 0 0 0 403 G G e 41.7 5jg8_B 13 0 0 4 0 30 4 0 21 0 0 20 0 4 0 5 0 0 0 0 404 Q H b 0.0 5jg8_B 0 0 0 8 0 0 4 0 4 4 4 0 0 55 0 10 10 0 0 0 405 L H b 0.0 5jg8_B 0 0 0 0 26 0 0 0 0 55 15 0 0 0 0 5 0 0 0 0 406 Q H e 36.7 5jg8_B alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. 7 0 9 25 0 0 0 0 0 20 0 0 0 21 9 5 0 4 0 0 407 W H e 23.5 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 408 L H b 0.0 5jg8_B 0 0 0 0 15 0 0 4 0 73 5 0 0 0 0 0 0 4 0 0 409 V H b 0.7 5jg8_B 0 0 0 26 0 27 0 15 5 0 0 5 0 0 5 0 0 17 0 0 410 G H e 52.4 5jg8_B 0 0 11 12 4 5 0 11 5 0 0 19 0 7 0 7 0 8 0 11 411 E H b 18.1 5jg8_B 0 0 0 17 0 0 0 0 0 0 0 0 0 27 0 0 32 23 0 0 412 L H b 0.6 5jg8_B 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 413 Q H b 7.1 5jg8_B 5 0 7 19 5 0 5 7 4 0 0 16 0 25 0 4 4 0 0 0 414 A H e 27.7 5jg8_B 24 0 13 28 0 0 0 8 0 0 0 15 0 5 0 6 0 0 0 0 415 A H b 0.9 5jg8_B 37 0 0 0 4 0 0 3 0 8 17 0 0 0 0 25 0 0 0 5 A->V:LP/P:rs1451199: Niemann-Pick disease B (NPDB) ; 416 E H b 18.1 5jg8_B 0 0 0 27 0 0 0 0 7 6 0 0 0 11 38 12 0 0 0 0 417 D H e 72.2 5jg8_B 8 0 13 9 0 0 0 0 9 10 0 12 0 21 7 9 0 0 3 0 418 R H e 50.6 5jg8_B 15 0 4 0 0 0 0 4 15 0 0 16 0 0 41 0 0 5 0 0 419 G T e 73.8 5jg8_B 0 0 0 0 0 80 0 0 11 0 0 8 0 0 0 0 0 0 0 0 420 D b 5.6 5jg8_B 0 0 17 38 0 0 0 0 0 0 38 7 0 0 0 0 0 0 0 0 421 K E e 25.9 5jg8_B 0 0 0 0 0 0 0 0 67 5 7 0 0 9 5 7 0 0 0 0 422 V E b 0.7 5jg8_B 5 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95 0 0 423 H E b 0.5 5jg8_B 0 0 0 0 0 0 18 5 0 5 0 0 0 0 0 0 0 0 37 35 H->Y:LP/P:rs1200741: Niemann-Pick disease B (NPDB) ;H->R:LP/P:rs7674920: Niemann-Pick disease A (NPDA) ; 424 I E b 0.6 5jg8_B 0 0 0 0 0 0 0 49 0 39 0 0 0 0 0 0 0 12 0 0 425 I E b 1.2 5jg8_B 0 0 0 0 0 0 0 44 0 10 5 0 0 0 0 23 4 13 0 0 426 G E b 0.0 5jg8_B 22 0 0 0 0 74 0 0 0 0 0 0 0 0 0 5 0 0 0 0 G->S:LP/P:rs1554935: Niemann-Pick disease A (NPDA) ; 427 H S b 0.0 5jg8_B PC ZN ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" H->R:LP/P:rs7947276: Niemann-Pick disease B (NPDB) ; 428 I S b 2.9 5jg8_B 0 0 0 0 0 0 0 44 0 0 0 0 0 0 0 0 0 56 0 0 429 P b 0.0 5jg8_B 0 0 0 0 7 0 0 0 0 0 0 0 93 0 0 0 0 0 0 0 430 P T b 0.0 5jg8_B 0 0 5 0 0 0 0 0 5 0 0 0 78 0 0 0 0 11 0 0 431 G T e 20.2 5jg8_B 9 0 4 0 0 67 0 0 4 0 0 8 0 0 0 5 0 0 0 0 432 H S e 44.5 5jg8_B SO4 5 0 4 14 8 0 12 0 4 0 0 4 0 6 6 9 0 0 0 28 433 C S b 0.0 5jg8_B 5 33 0 0 11 0 0 7 0 10 6 8 0 0 0 5 5 0 5 4 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" C->R:LP/P:rs7795285: Niemann-Pick disease B (NPDB) ; 434 L b 12.9 5jg8_B 4 0 4 12 0 0 0 4 5 30 0 0 3 7 9 0 5 0 0 17 L->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 435 K S e 44.3 5jg8_B NAG 0 0 17 16 0 7 0 0 41 0 0 4 0 6 4 7 0 0 0 0 436 S H b 10.2 5jg8_B NAG 0 0 5 0 0 20 0 0 8 9 0 8 0 0 0 25 10 0 0 13 437 W H b 1.2 5jg8_B 4 13 5 0 11 0 3 0 0 4 0 0 0 3 0 3 0 0 38 15 W->C:LP/P:-: Niemann-Pick disease B (NPDB) ; 438 S H b 0.0 5jg8_B 15 8 9 0 0 0 0 0 7 0 0 19 0 0 0 20 0 8 0 14 S->R:LP/P:rs2676070: Niemann-Pick disease B (NPDB) ; 439 W H e 35.1 5jg8_B 5 0 4 20 10 0 0 3 0 9 0 0 0 4 0 7 5 0 30 3 440 N H b 3.6 5jg8_B 1 0 4 4 0 1 0 0 17 1 5 27 0 17 5 10 3 0 4 0 441 Y H b 0.0 5jg8_B 1 4 0 0 15 1 0 0 9 17 0 0 0 0 0 1 5 0 0 44 442 Y H b 0.0 5jg8_B 4 0 0 5 15 5 5 4 0 15 0 0 0 0 0 1 6 3 0 35 443 R H e 25.3 5jg8_B 1 0 23 5 0 1 0 1 20 5 0 10 1 9 11 10 1 1 0 0 444 I H b 0.6 5jg8_B 1 0 1 1 0 1 0 41 5 19 0 1 1 1 1 5 1 18 4 0 445 V H b 2.0 5jg8_B 5 0 0 0 20 0 0 17 0 19 7 0 0 0 0 0 7 22 0 0 446 A H b 3.6 5jg8_B 6 0 0 3 0 5 11 0 5 5 0 9 0 12 18 12 8 0 0 6 447 R H b 9.5 5jg8_B 0 0 7 29 0 0 0 0 13 0 0 0 0 15 36 0 0 0 0 0 448 Y T b 0.9 5jg8_B 0 0 0 0 15 0 7 0 0 0 0 0 0 0 0 0 0 0 0 77 Y->C:LP/P:rs7471433: Niemann-Pick disease A (NPDA) ; 449 E T b 7.5 5jg8_B 5 0 0 16 0 0 7 0 0 0 0 0 0 11 30 30 0 0 0 0 450 N T e 30.9 5jg8_B 0 0 58 0 0 0 0 0 0 0 0 18 0 0 7 11 7 0 0 0 451 T T b 6.5 5jg8_B 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 38 37 0 0 452 L E b 6.7 5jg8_B 0 0 0 0 0 0 0 82 0 8 0 0 0 0 0 0 0 11 0 0 L->P:LP/P:-: Niemann-Pick disease A (NPDA) ; 453 A E b 12.5 5jg8_B 36 0 0 5 0 0 0 24 0 4 0 0 0 0 0 0 7 24 0 0 A->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 454 A E b 3.6 5jg8_B 18 0 0 0 5 67 0 0 0 0 0 0 0 5 0 5 0 0 0 0 A->V:LP/P:rs1402734: Niemann-Pick disease B (NPDB) ; 455 Q E b 0.0 5jg8_B 0 0 0 0 0 32 9 0 0 0 5 0 0 47 0 8 0 0 0 0 456 F E b 0.0 5jg8_B 0 0 0 0 56 0 0 5 0 30 0 0 0 0 0 0 0 9 0 0 457 F E b 0.0 5jg8_B 0 0 0 0 46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 54 458 G E b 0.0 5jg8_B 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 G->D:LP/P:-: Niemann-Pick disease B (NPDB) ; 459 H E b 18.8 5jg8_B PC ZN SO4:ACT 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 460 T E b 15.6 5jg8_B SO4 0 0 5 5 0 0 7 7 0 0 38 0 0 0 0 0 38 0 0 0 461 H E b 8.9 5jg8_B PC ZN ACT 0 0 0 0 0 0 62 0 0 0 0 38 0 0 0 0 0 0 0 0 BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":BINDING:/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" 462 V S b 13.3 5jg8_B 0 0 0 0 0 0 0 22 0 5 7 0 0 0 22 5 12 16 0 10 463 D b 5.6 5jg8_B 0 0 89 5 0 0 0 0 0 0 0 5 0 0 0 0 0 0 0 0 464 E E b 6.5 5jg8_B 0 0 0 19 0 0 38 0 5 0 0 0 0 10 0 19 5 0 0 5 465 F E b 2.9 5jg8_B 0 0 0 0 82 0 0 13 0 6 0 0 0 0 0 0 0 0 0 0 F->S:LP/P:rs1319643: Niemann-Pick disease A (NPDA) ; 466 E E b 2.5 5jg8_B 2 0 1 11 1 1 0 1 1 2 20 1 1 1 15 20 7 8 0 7 467 V E b 0.0 5jg8_B 0 0 0 0 13 0 0 11 0 5 15 0 0 0 0 0 0 56 0 0 468 F E b 0.0 5jg8_B 0 0 0 0 47 0 0 8 0 19 7 0 0 9 0 0 0 0 0 11 469 Y E b 3.5 5jg8_B 0 0 0 0 9 0 8 6 0 8 0 0 0 0 0 21 0 0 0 49 Y->S:LP/P:rs2676070: Niemann-Pick disease A (NPDA) ; 470 D b 5.6 5jg8_B 7 0 79 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 471 E T e 40.2 5jg8_B 0 0 29 23 8 0 0 0 15 0 0 9 0 0 0 0 0 13 0 0 472 E T e 75.4 5jg8_B 12 0 27 11 0 1 0 1 8 1 0 19 15 1 1 1 1 1 0 0 473 T T e 52.6 5jg8_B 2 0 6 8 1 6 0 1 9 2 0 12 7 1 1 10 17 8 0 7 474 L S b 18.5 5jg8_B 2 0 7 1 1 2 7 1 8 35 0 7 6 1 1 8 6 6 0 1 475 S e 60.9 5jg8_B 2 0 1 8 1 21 6 1 1 2 0 1 1 1 7 29 16 1 0 1 476 R S e 37.2 5jg8_B 6 0 1 7 1 1 0 8 11 1 0 17 1 1 26 10 8 1 0 0 R->W:LP/P:rs1828129: Niemann-Pick disease B (NPDB) ;R->Q:US:rs7635669: Niemann-Pick disease B (NPDB) ; 477 P E b 13.2 5jg8_B 1 0 10 1 0 1 0 0 1 1 0 9 73 0 0 1 1 1 0 0 P->L:LP/P:rs7535088: Niemann-Pick disease A (NPDA) ;P->L:LP/P:rs7535088: Niemann-Pick disease B (NPDB) ; 478 L E b 9.0 5jg8_B 1 0 0 1 7 1 9 29 1 15 6 0 0 0 0 1 20 8 0 0 479 A E b 6.2 5jg8_B 8 0 0 1 0 14 6 0 1 1 0 42 0 0 0 15 1 1 0 9 480 V E b 6.7 5jg8_B 5 0 0 1 16 1 0 7 1 1 7 0 0 0 0 16 1 43 0 0 481 A E b 0.0 5jg8_B 11 0 0 1 0 16 0 6 1 9 25 13 0 0 0 1 1 14 0 0 482 F E b 2.9 5jg8_B 1 0 0 1 50 1 0 0 1 1 0 0 0 10 0 1 1 1 6 26 F->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 483 L E b 0.0 5jg8_B 7 0 0 1 0 1 0 27 1 31 0 0 0 0 0 7 6 16 0 0 484 A E b 0.0 5jg8_B 42 0 0 1 0 10 0 0 1 1 0 0 0 0 0 19 16 7 0 0 A->E:LP/P:rs2676070: Niemann-Pick disease A (NPDA) ; 485 P E b 1.6 5jg8_B 0 0 0 0 0 9 0 0 0 0 0 0 82 0 0 9 0 0 0 0 486 S b 0.0 5jg8_B 15 0 0 0 0 10 0 0 0 9 0 0 0 0 0 57 0 9 0 0 487 A S b 0.0 5jg8_B 19 0 9 0 0 0 0 9 0 19 0 0 0 0 0 0 0 43 0 0 A->V:LB/B:rs1416412: -; 488 T S b 0.0 5jg8_B 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 91 0 0 0 T->A:LP/P:-: Niemann-Pick disease B (NPDB) ; 489 T b 0.0 5jg8_B 0 0 0 13 0 0 0 0 0 0 0 9 33 0 0 0 45 0 0 0 490 Y T e 22.2 5jg8_B SO4 0 0 0 0 10 0 0 0 0 10 0 0 0 0 4 18 0 20 6 32 Y->N:LP/P:rs3981234: Niemann-Pick disease B (NPDB) ; 491 I T e 56.7 5jg8_B SO4 0 0 6 6 0 0 0 19 11 4 6 0 10 12 0 7 0 0 0 18 492 G T e 20.2 5jg8_B 0 0 16 0 9 33 5 0 0 0 0 16 0 0 0 4 4 0 6 6 G->S:LP/P:rs1448733: Niemann-Pick disease B (NPDB) ; 493 L b 4.5 5jg8_B 0 0 0 0 0 0 7 18 0 16 0 13 0 18 0 0 0 21 0 7 494 N b 2.4 5jg8_B 0 0 0 8 7 0 0 0 11 0 0 74 0 0 0 0 0 0 0 0 N->I:LP/P:-: Niemann-Pick disease A (NPDA) ; 495 P b 0.0 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 496 G E b 0.0 5jg8_B 26 0 0 0 0 46 0 0 11 0 0 0 0 0 0 6 10 0 0 0 G->S:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 497 Y E b 1.7 5jg8_B 0 0 0 0 16 0 0 14 0 7 0 0 0 0 0 0 0 12 0 51 498 R E b 0.4 5jg8_B 0 0 0 0 0 0 0 0 10 0 0 0 0 0 79 0 0 11 0 0 R->L:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ;R->C:LP/P:rs7699047: Niemann-Pick disease B (NPDB) ;R->H:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 499 V E b 0.0 5jg8_B 0 0 0 0 0 0 0 40 11 22 0 0 0 10 0 0 0 16 0 0 500 Y E b 0.0 5jg8_B 0 0 0 0 42 0 0 0 0 0 0 0 0 0 0 11 0 0 0 47 501 Q E b 12.2 5jg8_B 0 0 0 31 0 0 0 0 0 11 0 0 0 34 0 0 24 0 0 0 502 I E b 0.6 5jg8_B 3 1 2 3 9 3 1 46 2 4 1 2 2 2 2 3 2 9 1 1 503 D E b 1.9 5jg8_B 3 1 60 3 2 3 1 2 2 4 1 2 2 2 2 3 2 3 1 1 504 G b 1.2 5jg8_B 16 1 3 4 2 29 1 3 3 5 1 3 3 2 3 10 3 4 1 2 505 N S e 45.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. SO4 4 1 3 4 2 11 1 3 3 5 1 20 3 14 3 4 3 11 1 2 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." 506 Y S e 30.0 5jg8_B 2 0 1 1 1 2 8 1 1 2 0 1 1 1 1 1 1 1 0 72 507 S T e 89.1 5jg8_B 12 0 29 7 1 1 0 1 16 1 0 7 12 1 1 8 1 1 0 0 S->G:LB/B:-: -; 508 G T e 94.0 5jg8_B 1 0 1 1 1 26 0 8 1 2 0 1 17 1 11 11 1 1 0 15 G->R:LB/B:rs1050239: -; 509 S b 4.7 5jg8_B 18 0 1 1 1 9 0 1 1 2 0 8 1 11 9 27 8 1 0 1 510 S b 6.2 5jg8_B 1 0 16 1 0 1 0 1 8 1 0 1 1 0 1 29 39 1 0 0 MOD_RES:/note="Phosphoserine; by PKC/PRKCD":MUTAGEN:/note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762":MOD_RES:/note="Phosphoserine; by PKC/PRKCD":MUTAGEN:/note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" S->F:LB/B:rs2006526: -; 511 H b 2.6 5jg8_B 1 0 1 1 14 7 11 1 11 11 0 8 1 0 1 1 1 1 0 30 512 V b 14.7 5jg8_B 8 0 1 1 0 1 0 1 16 1 0 16 1 15 1 6 15 12 0 7 513 V E b 4.0 5jg8_B 1 0 1 1 0 1 0 25 1 40 0 1 1 0 1 1 1 26 0 0 514 L E b 19.1 5jg8_B 1 0 1 1 0 1 0 8 18 35 6 1 1 0 1 1 11 15 0 0 515 D E b 15.4 5jg8_B 0 0 75 17 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 516 H E b 1.0 5jg8_B 7 0 0 0 7 0 11 10 0 17 21 0 0 0 0 6 0 0 0 22 H->Q:LP/P:-: Niemann-Pick disease B (NPDB) ; 517 E E b 3.0 5jg8_B 0 0 0 19 0 0 0 0 7 12 0 0 11 0 0 6 17 14 0 14 E->V:LP/P:rs1427870: Niemann-Pick disease B (NPDB) ; 518 T E b 0.0 5jg8_B 10 0 0 7 0 0 0 0 0 0 0 0 0 30 0 0 53 0 0 0 519 Y E b 6.5 5jg8_B 0 0 0 0 18 0 0 0 0 0 0 0 0 0 0 0 0 0 7 75 Y->C:LP/P:rs3718372: Niemann-Pick disease A (NPDA) ; 520 I E b 1.2 5jg8_B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. 0 0 0 0 34 0 14 11 0 0 0 0 11 0 0 0 0 0 7 23 I->L:LP/P:-: Niemann-Pick disease B (NPDB) ; 521 L E b 0.0 5jg8_B 21 0 0 11 7 0 0 0 0 29 9 0 0 0 0 10 13 0 0 0 522 N e 23.0 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 23 0 0 0 0 0 0 0 0 77 0 0 0 0 0 0 0 0 CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion.":CARBOHYD:/note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8":MUTAGEN:/note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion." N->S:LP/P:-: Niemann-Pick disease B (NPDB) ; 523 L H b 0.0 5jg8_B 0 0 0 0 0 0 0 8 0 76 0 0 0 0 0 0 0 17 0 0 524 T H e 57.1 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 7 0 0 0 0 0 0 0 0 0 0 5 11 66 0 0 10 525 Q H e 62.2 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 11 40 0 0 0 10 7 0 0 0 0 24 0 7 0 0 0 0 Q->H:LP/P:-: Niemann-Pick disease B (NPDB) ; 526 A H b 2.7 5jg8_B 65 0 0 11 0 0 0 0 0 0 0 14 0 0 0 10 0 0 0 0 527 N T e 24.2 5jg8_B 0 0 0 0 11 0 0 7 0 0 0 75 0 0 0 0 7 0 0 0 528 I S e 56.7 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 17 0 0 12 0 1 0 11 0 44 7 0 0 0 0 1 0 6 0 0 529 P T e 96.1 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 4 0 0 7 0 0 0 0 32 0 0 25 7 10 0 7 8 0 0 0 530 G T e 96.4 5jg8_B 0 0 7 0 0 74 0 0 0 0 0 7 8 0 0 0 0 0 0 0 531 A e 33.9 5jg8_B 15 0 0 21 0 4 10 0 20 0 0 7 0 0 0 0 24 0 0 0 532 I e 83.0 5jg8_B 2 1 1 8 1 2 1 12 9 10 11 9 1 1 1 2 14 13 0 1 533 P e 20.2 5jg8_B 1 0 8 1 1 13 0 1 1 2 0 1 42 1 1 17 1 9 0 1 534 H e 67.0 5jg8_B 1 0 0 7 0 0 7 4 8 1 0 41 0 0 11 4 7 8 0 0 535 W E b 7.2 5jg8_B 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 81 11 W->R:LP/P:rs1554935: Niemann-Pick disease A (NPDA) ;W->R:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 536 Q E e 30.6 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 25 0 0 0 0 12 6 0 0 0 18 0 11 18 7 0 4 537 L e 31.5 5jg8_B 0 0 0 10 0 0 0 0 7 66 0 0 0 5 4 0 0 7 0 0 538 L e 25.3 5jg8_B 0 0 0 55 0 0 0 0 0 29 0 0 0 0 0 7 8 0 0 0 539 Y b 4.8 5jg8_B 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 Y->H:LP/P:-: Niemann-Pick disease A (NPDA) ; 540 R B e 36.4 5jg8_B 0 0 18 0 0 0 0 4 0 0 0 12 0 14 26 16 4 4 0 0 541 A H b 0.0 5jg8_B 45 0 0 0 11 0 0 0 0 29 0 0 0 0 0 0 15 0 0 0 542 R H e 41.1 5jg8_B 0 0 0 0 0 0 0 0 8 0 0 8 0 0 28 0 44 11 0 0 543 E H e 78.9 5jg8_B 0 0 0 48 0 0 0 0 0 0 8 7 0 25 0 11 0 0 0 0 544 T H e 31.8 5jg8_B 33 0 0 8 8 0 7 11 0 8 0 0 0 0 0 0 24 0 0 0 545 Y H b 3.5 5jg8_B 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 84 546 G T e 65.5 5jg8_B 0 0 20 0 0 39 0 0 0 0 0 23 0 13 0 4 0 0 0 0 547 L b 2.8 5jg8_B 0 0 0 0 0 0 0 27 0 21 24 0 0 0 0 0 8 20 0 0 548 P S e 69.0 5jg8_B 16 0 27 4 8 0 0 0 8 0 0 0 32 5 0 0 0 0 0 0 549 N e 32.1 5jg8_B 0 0 57 0 0 8 0 0 0 0 0 34 0 0 0 0 0 0 0 0 N->K:LP/P:-: Niemann-Pick disease B (NPDB) ; 550 T S b 1.9 5jg8_B 20 0 0 0 7 0 0 0 0 49 0 0 0 20 0 0 4 0 0 0 551 L S e 26.4 5jg8_B 0 0 0 0 0 0 0 8 0 8 4 0 0 18 0 43 7 0 0 11 L->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 552 P H b 19.4 5jg8_B 6 0 0 0 0 11 0 0 0 0 0 0 77 0 0 0 0 6 0 0 553 T H e 48.7 5jg8_B 4 0 0 4 0 0 6 18 13 8 0 0 0 7 0 6 25 8 0 0 554 A H b 6.2 5jg8_B 8 0 0 8 0 11 0 0 0 0 0 0 0 0 0 72 0 0 0 0 555 W H b 1.2 5jg8_B 0 0 0 0 0 0 0 0 0 29 26 0 0 0 0 0 0 0 36 8 556 H H b 17.8 5jg8_B 0 0 7 0 0 0 29 0 0 0 0 27 0 0 0 7 8 0 0 21 557 N H e 50.9 5jg8_B 4 0 12 8 0 9 0 0 21 7 0 9 0 8 0 11 12 0 0 0 558 L H b 0.0 5jg8_B 21 0 0 0 0 0 0 0 0 49 8 0 0 0 0 0 0 22 0 0 559 V H b 0.7 5jg8_B 22 0 0 0 0 0 0 23 0 12 11 0 0 0 0 7 0 17 0 8 560 Y H e 23.9 5jg8_B 0 0 13 20 0 0 0 0 9 8 0 8 0 23 0 0 6 0 0 13 561 R H e 37.9 5jg8_B 0 0 0 0 0 0 0 0 15 8 0 7 0 26 44 0 0 0 0 0 562 M H b 1.4 5jg8_B 0 0 0 0 13 0 0 26 0 19 41 0 0 0 0 0 0 0 0 0 563 R H e 30.0 5jg8_B SO4 21 0 0 0 8 0 0 0 17 0 0 7 0 8 13 0 9 11 7 0 564 G H e 76.2 5jg8_B SO4 0 0 4 0 0 10 0 4 8 0 0 0 0 5 0 32 36 0 0 0 565 D e 42.0 5jg8_B SO4 0 0 40 11 0 0 0 0 0 0 0 16 0 0 0 26 0 8 0 0 D->Y:LP/P:-: Niemann-Pick disease B (NPDB) ; 566 M H e 30.9 5jg8_B SO4 0 0 8 12 0 0 0 0 0 0 4 18 6 6 0 26 19 0 0 0 567 Q H e 77.0 5jg8_B SO4 0 0 0 0 0 0 6 0 25 0 0 0 0 13 0 40 16 0 0 0 568 L H b 14.6 5jg8_B 0 0 0 0 0 0 0 17 8 29 15 0 0 25 0 0 6 0 0 0 569 F H b 0.0 5jg8_B 0 0 0 0 66 0 0 0 0 26 0 0 0 0 8 0 0 0 0 0 570 Q H e 37.2 5jg8_B 0 0 0 15 0 0 0 9 0 16 0 28 0 24 7 0 0 0 0 0 571 T H e 33.1 5jg8_B 0 0 15 0 0 0 0 0 42 0 0 11 0 0 12 8 13 0 0 0 572 F H b 1.9 5jg8_B 0 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 72 F->L:LP/P:-: Niemann-Pick disease A (NPDA) ; 573 W H b 13.1 5jg8_B 2 0 1 1 1 2 17 1 1 2 0 1 1 1 1 2 1 10 15 39 574 F H e 45.5 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 0 0 0 9 32 0 9 0 6 0 0 5 0 9 8 0 0 8 0 13 575 L H b 3.9 5jg8_B 1 0 0 9 0 1 8 0 0 23 0 10 0 0 0 1 1 14 0 29 576 Y H b 17.8 5jg8_B 9 0 0 0 16 0 9 0 0 0 0 9 0 0 0 0 0 0 0 57 577 H T b 11.5 5jg8_B 0 0 0 0 29 0 14 0 0 9 0 31 0 0 0 0 0 0 0 16 H->D:US:-: Niemann-Pick disease B (NPDB) ; 578 K T b 0.0 5jg8_B 0 0 0 0 0 0 0 0 14 0 0 0 0 0 27 39 0 20 0 0 K->N:LP/P:rs7473424: Niemann-Pick disease B (NPDB) ; 579 G T e 20.2 5jg8_B NAG 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..:alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. 8 0 0 0 0 14 0 0 0 0 0 17 0 0 9 29 0 22 0 0 G->S:LP/P:rs1200741: Niemann-Pick disease A (NPDA) ; 580 H e 34.0 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 0 0 9 0 23 0 0 0 0 0 0 0 0 31 0 0 0 38 581 P e 36.4 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] 0 0 30 0 0 0 0 0 0 0 0 0 31 0 0 9 0 0 0 30 582 P e 51.9 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 0 0 0 8 0 9 0 9 0 0 0 15 32 0 0 27 0 0 0 0 583 S S e 102.3 5jg8_B ASM_HUMAN:Sphingomyelin phosphodiesterase[528 aa] SO4 7 0 0 0 0 0 7 0 9 0 0 8 0 9 9 43 9 0 0 0 584 E S e 79.4 5jg8_B SO4 19 0 0 32 0 7 0 0 17 8 0 0 0 0 0 1 1 11 0 0 585 P e 84.5 5jg8_B SO4 1 0 1 1 1 10 0 7 1 2 0 1 37 1 1 10 17 8 0 1 586 C b 18.7 5jg8_B SO4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 587 G e 21.4 5jg8_B SO4 0 0 47 7 0 14 0 0 0 0 0 9 0 6 0 0 8 0 0 8 588 T H e 55.2 5jg8_B SO4 0 0 7 15 0 6 0 0 5 0 0 0 0 28 0 17 23 0 0 0 589 P H e 79.8 5jg8_B SO4 15 0 0 0 0 0 5 9 14 0 0 0 14 9 5 15 14 0 0 0 590 C H e 21.3 5jg8_B SO4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 591 R H b 8.7 5jg8_B 0 0 0 0 0 0 0 0 37 0 0 0 0 18 39 7 0 0 0 0 592 L H e 27.5 5jg8_B 5 0 0 0 0 0 0 13 9 22 15 9 0 0 0 0 18 0 0 8 593 A H e 58.0 5jg8_B 14 0 8 7 11 9 0 9 9 9 0 0 0 15 0 0 8 0 0 0 594 T H b 8.4 5jg8_B 0 0 0 0 8 0 13 0 0 9 0 0 0 29 0 0 14 0 9 17 595 L H b 0.0 5jg8_B 0 0 0 0 0 0 0 33 0 32 9 0 0 0 0 0 0 26 0 0 596 C H e 26.7 5jg8_B 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 597 A H e 36.6 5jg8_B 57 0 11 0 0 0 0 0 10 0 0 11 0 0 0 11 0 0 0 0 598 Q H b 1.0 5jg8_B 0 0 0 0 0 0 0 41 0 13 20 7 0 19 0 0 0 0 0 0 Q->R:LP/P:rs1554935: Niemann-Pick disease B (NPDB) ; 599 L H b 0.0 5jg8_B 0 0 0 0 0 0 0 0 23 26 21 0 0 9 21 0 0 0 0 0 L->F:US:rs1385319: Niemann-Pick disease B (NPDB) ; 600 S b 19.5 5jg8_B 0 0 7 0 0 0 9 0 12 0 13 21 0 9 0 31 0 0 0 0 601 A b 0.9 5jg8_B 31 0 0 0 0 24 0 0 0 21 0 0 0 0 0 7 0 18 0 0 602 R S b 7.9 5jg8_B 20 0 29 0 0 0 13 0 0 0 7 0 0 0 31 0 0 0 0 0 R->H:LP/P:rs3701290: Niemann-Pick disease A (NPDA) ;R->H:LP/P:rs3701290: Niemann-Pick disease B (NPDB) ;R->P:LP/P:-: Niemann-Pick disease B (NPDB) ; 603 A T b 5.4 5jg8_B 13 0 0 0 9 0 13 9 0 6 0 7 0 0 0 25 0 8 0 11 604 D T e 49.4 5jg8_B 0 0 28 0 0 0 0 14 0 11 0 22 0 0 0 0 0 6 0 18 605 S b 8.6 5jg8_B 9 0 18 0 0 0 0 0 11 0 0 0 0 0 0 53 9 0 0 0 S->G:LB/B:-: -; 606 P G e 83.7 5jg8_B 0 0 7 12 0 0 0 0 0 0 0 0 19 0 0 0 13 0 0 50 607 A G e 48.2 5jg8_B 35 7 0 6 0 0 0 0 0 13 0 0 0 0 0 12 17 0 0 11 608 L G b 5.1 5jg8_B 0 0 21 11 12 0 0 0 0 26 0 0 0 0 0 0 18 0 0 13 609 C G b 12.7 5jg8_B 0 93 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8":DISULFID:ECO:0000269|PubMed:12631268, ECO:0000269|PubMed:27349982, ECO:0007744|PDB:5JG8" 610 R G e 54.5 5jg8_B 1 0 16 1 0 1 0 15 1 13 0 1 1 11 37 1 1 1 0 0 R->C:US:rs3759151: Niemann-Pick disease B (NPDB) ; 611 H G e 49.7 5jg8_B 1 0 1 1 0 1 89 1 1 1 0 1 1 0 1 1 1 1 0 0 612 L G b 1.1 5jg8_B 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 613 M e 84.5 5jg8_B 0 0 0 0 0 0 0 0 0 0 41 0 0 0 0 0 0 20 0 39 614 P 39 0 0 0 0 0 0 0 0 0 0 0 61 0 0 0 0 0 0 0 615 D 0 0 40 0 0 0 0 0 0 0 0 21 0 0 0 39 0 0 0 0 616 G 20 0 0 0 0 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 617 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 61 39 0 0 0 618 L 0 0 0 0 0 0 0 0 0 61 0 0 0 0 0 0 39 0 0 0 619 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 620 E 0 0 41 20 0 0 0 0 0 0 0 0 0 0 0 0 0 39 0 0 621 A 41 0 0 0 0 0 0 0 0 0 0 0 39 0 0 0 0 20 0 0 622 Q 0 0 0 0 0 0 0 0 0 0 0 21 0 79 0 0 0 0 0 0 623 S 0 0 0 0 0 0 0 0 0 0 0 0 0 0 34 66 0 0 0 0 624 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 625 W 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 626 P 0 0 0 0 0 0 0 0 0 0 0 0 33 0 0 67 0 0 0 0 627 R 0 0 0 0 0 0 0 0 0 0 33 0 0 0 67 0 0 0 0 0 628 P 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 629 L 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 630 F 0 0 0 0 33 0 0 0 0 67 0 0 0 0 0 0 0 0 0 0 631 C 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0