Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
3207930 164 29 P01185(NEU2_HUMAN) RecName: Full=Vasopressin-neurophysin 2-copeptin;AltName: Full=AVP-NPII;Contains: RecName: Full=Arg-vasopressin; AltName: Full=Arginine-vasopressin;Contains: RecName: Full=Neurophysin 2; AltName: Full=Neurophysin-II;Contains: RecName: Full=Copeptin;Flags: Precursor;
QUERYSEQ
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGFHRRARASDRSNATQLDGPAGALLLRLVQLA
GAPEPFEPAQPDAY
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
1M----
M
SIGNAL DISORDER predicted by DISOPRED SIGNAL
2P----
PSTLA
SIGNAL DISORDER predicted by DISOPRED SIGNAL
3D----
DGLNYEH
SIGNAL DISORDER predicted by DISOPRED SIGNAL
4T----
TSAP
SIGNAL DISORDER predicted by DISOPRED SIGNAL
5M----
TAYVFSM
SIGNAL DISORDER predicted by DISOPRED SIGNAL
6L----
LIV
SIGNAL DISORDER predicted by DISOPRED SIGNAL
7P----
PLSA
SIGNAL DISORDER predicted by DISOPRED SIGNAL
8A----
LAVT
SIGNAL DISORDER predicted by DISOPRED SIGNAL
9C----
CATLS
SIGNAL DISORDER predicted by DISOPRED SIGNAL
10F----
FLVACI
SIGNAL DISORDER predicted by DISOPRED SIGNAL
11L----
LVAFI
SIGNAL DISORDER predicted by DISOPRED SIGNAL
12G----
GCLYFS
SIGNAL DISORDER predicted by DISOPRED SIGNAL
13L----
LISAWG
SIGNAL DISORDER predicted by DISOPRED SIGNAL
14L----
LS
SIGNAL DISORDER predicted by DISOPRED SIGNAL
15A----
ASCL
SIGNAL SIGNAL
16F----
LVFQA
SIGNAL SIGNAL
17S----
STCA
SIGNAL SIGNAL S->F:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
18S----
SQNDT
SIGNAL SIGNAL
19A----
AG
SIGNAL SIGNAL A->T:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs3879065 [MIM:125700];A->V:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs3879065 [MIM:125700]
20C----
C
DISULFID PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" DISULFID PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
21Y----
YF
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" Y->H:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
22F----
IFL
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
23Q----
QRGST
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
24N----
N
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
25C----
C
DISULFID PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" DISULFID PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
26P----
PL
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" P->L:(14.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1428863 [MIM:125700]
27R----
RKNIEL
PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
28G----
GD
SITE /note="Important for agonist activity on V1aR/AVPR1A" MOD_RES /note="Glycine amide" MUTAGEN /note="G->V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR)." PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515" SITE /note="Important for agonist activity on V1aR/AVPR1A" MOD_RES /note="Glycine amide" MUTAGEN /note="G->V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR)." PEPTIDE /note="Arg-vasopressin" /id="PRO_0000020515"
29G----
G
30K----
KE
31R----
R
32A e 96.4 2bn2_A
ASDNEGKLTV
33M e 85.0 2bn2_A
VLIAYMFQTEGKS
34SSe 41.4 2bn2_A
DPLHSQAMGIEFKNRTV
35DGe 82.1 2bn2_A
DEMATS
36LGe 92.1 2bn2_A hetero NEU2_BOVIN
TLVIGRMAFPS
37EGe 55.8 2bn2_A
DQEPGAYTSVK
38L e 30.9 2bn2_A hetero metal CD
LVSPTGIQMA
39R e 32.4 2bn2_A compound PHE homo
RTKHP
40Q e 35.2 2bn2_A
QKEPSAT
41C b 6.7 2bn2_A hetero compound TYR
CADEGIKLNPQRSTV
DISULFID DISULFID
42L b 14.0 2bn2_A
MLAIVDEGKNPQRST
43PEe 34.9 2bn2_A
PSFAKT
44CEb 4.0 2bn2_A
C
DISULFID DISULFID
45GSe 26.2 2bn2_A hetero NEU2_BOVIN
GMSKAELTV
G->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
46PGe 52.7 2bn2_A hetero NEU2_BOVIN
PYLNAGSDEFIKQRTV
47GGe 76.2 2bn2_A hetero NEU2_BOVIN
GCRDEAIKLNPQSTV
48GGe 46.4 2bn2_A
GDNSEALV
G->V:(1.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
49K e 59.4 2bn2_A
KRFQVTA
50GEb 3.6 2bn2_A
GALS
51REe 35.2 2bn2_A
RQHNLAGS
R->C:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
52CEb 2.0 2bn2_A hetero compound TYR
C
DISULFID DISULFID C->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
53FEb 9.6 2bn2_A hetero compound TYR
FVLY
54GEb 11.9 2bn2_A hetero compound TYR
GA
G->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700];G->V:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
55PTe 29.5 2bn2_A hetero compound TYR homo
P
P->L:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
56STe 39.1 2bn2_A homo
SNHRGQ
57IEb 1.2 2bn2_A
IVT
58CEb 0.0 2bn2_A
C
DISULFID DISULFID C->F:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
59CEb 0.7 2bn2_A
C
DISULFID DISULFID C->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->Y:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
60AEb 7.1 2bn2_A
GA
61DTe 74.1 2bn2_A
EDAGLQKPVS
62ETe 76.9 2bn2_A
EGDALRPS
63LTe 27.5 2bn2_A hetero NEU2_BOVIN homo
LIFKMRTVADEGPS
64GEe 29.8 2bn2_A hetero NEU2_BOVIN homo
G
65CEe 22.7 2bn2_A hetero NEU2_BOVIN homo
CG
DISULFID DISULFID
66FEe 20.1 2bn2_A hetero NEU2_BOVIN homo
ELYFGWH
67VEe 60.7 2bn2_A hetero NEU2_BOVIN homo
MVILRF
V->A:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs2893487 [MIM:125700]
68GSe 69.0 2bn2_A hetero NEU2_BOVIN homo
G
69TSe 33.8 2bn2_A hetero NEU2_BOVIN homo
TSG
70AGe 63.4 2bn2_A hetero NEU2_BOVIN
APGTSVEL
71EGe 39.2 2bn2_A homo
ECDW
72AGb 0.9 2bn2_A
ATIMS
73LGe 64.6 2bn2_A hetero NEU2_BOVIN
LANVEDRSMQ
74RGe 42.7 2bn2_A homo
RGVMSKTH
75CGb 0.0 2bn2_A hetero compound TYR
C
DISULFID DISULFID
76QGe 47.4 2bn2_A hetero NEU2_BOVIN
QAVKMERHISFL
77EGe 49.2 2bn2_A hetero NEU2_BOVIN homo
ERKQG
78EGb 9.0 2bn2_A hetero compound PHE TYR
E
E->G:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
79NGe 64.8 2bn2_A hetero compound TYR PHE
NDESTI
80YGe 83.5 2bn2_A hetero NEU2_BOVIN homo
YEFLDH
81L e 41.6 2bn2_A hetero NEU2_BOVIN compound PHE homo
LDSHNM
L->P:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
82PSe103.1 2bn2_A hetero NEU2_BOVIN compound PHE homo
PSLT
P->L:(5.0 %):LB/B - dbSNP:rs5195
83SSe 43.0 2bn2_A hetero compound PHE homo
STIEVA
84P e 72.9 2bn2_A hetero NEU2_BOVIN compound PHE
P
85C e 21.3 2bn2_A hetero compound PHE TYR
C
DISULFID DISULFID
86Q e 29.6 2bn2_A hetero
QEHRAKL
87S b 0.8 2bn2_A
VSAGTIP
S->F:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
88G e 20.2 2bn2_A
GFSLAKV
G->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];G->S:(6.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
89QSe 93.4 2bn2_A
GQR
90KSe 48.1 2bn2_A
KRQSDEW
91AEe 55.8 2bn2_A
PHRASVLDM
92CEb 6.7 2bn2_A
C
DISULFID DISULFID C->S:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->Y:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
93GTe 63.1 2bn2_A
GNAS
G->W:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700]
94STe 90.6 2bn2_A
SLNVDTAIY
95GTe 79.8 2bn2_A hetero
GENHATD
96GEb 3.6 2bn2_A
GTA
G->C:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];G->V:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs1219648 [MIM:125700];G->D:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
97REe 31.2 2bn2_A
RNIHSKPL
R->C:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];R->P:(4.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
98CEb 13.3 2bn2_A
C
DISULFID DISULFID C->G:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->S:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
99AEb 2.7 2bn2_A
AV
A->P:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
100AEb 2.7 2bn2_A
ASGTVR
101FTe 66.1 2bn2_A
PDASINYFLTV
102GTe 27.4 2bn2_A
G
103VEe 25.1 2bn2_A hetero NEU2_BOVIN homo
IVL
104CEb 5.3 2bn2_A
C
DISULFID DISULFID C->F:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->G:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
105CEb 0.0 2bn2_A
C
DISULFID DISULFID C->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->Y:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
106N b 17.6 2bn2_A
SDVNTGY
107DSe 58.6 2bn2_A hetero metal CD homo
DSAEHPTNV
108ESe 81.4 2bn2_A hetero NEU2_BOVIN metal CD homo
EDVQ
109S e 37.5 2bn2_A hetero NEU2_BOVIN homo
TSGA
110CEe 29.3 2bn2_A hetero NEU2_BOVIN homo
C
DISULFID DISULFID
111VEe 59.3 2bn2_A hetero NEU2_BOVIN homo
SVTAKLHMR
112TEe 77.3 2bn2_A hetero NEU2_BOVIN homo
VIMATLF
113E e 24.1 2bn2_A
DHENS
114PTe 88.4 2bn2_A
PSAQRLDTV
115ETe 63.8 2bn2_A
SEARDGTLNV
116C e 22.7 2bn2_A
C
DISULFID DISULFID C->G:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) dbSNP:rs7431538 [MIM:125700];C->R:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700];C->W:(0.0 %):LP/P Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]
117R e 83.0 1jk6_B
RLDEQSVHT
118E----
EDKVQSN
119G----
EGDAFIKLNPQRSTVY
G->V:(1.0 %):LB/B - dbSNP:rs1051744
120F----
FGVDSTEAL
121H----
DTSKPFHERGLAIV
122R----
ERQNAYDGIKLPSTV
123R----
RQEKDLSHP
124A----
ASDGTVILPQRY
DISORDER predicted by DISOPRED
125R----
REGSPI
DISORDER predicted by DISOPRED
126A----
VSAELPQ
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
127S----
STEDAGRFQP
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
128D----
DAEFQPSH
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
129R----
SREGPQVDY
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
130S----
SQAGKE
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
131N----
NDAESGKLTV
CARBOHYD /note="N-linked (GlcNAc...) asparagine" PEPTIDE /note="Copeptin" /id="PRO_0000020517" CARBOHYD /note="N-linked (GlcNAc...) asparagine" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
132A----
ALSTMQPVDEFGIKNR
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
133T----
TGLSANHDEKPV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
134Q----
GQTLVDRSAEKP
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
135L----
LMAHDEFGIKNPQRSTV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
136D----
DAGKENILPRSTV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
137G----
GANSTLDEFIKPQRVY
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
138P----
PSLVADEFGIKNQRTY
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
139A----
ASPTDEFGIKLNQRVY
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
140G----
GSRTADEIKLNPV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
141A----
DEAGIKLNPRSTV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
142L----
LVIF
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
143L----
LI
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
144L----
LRMQ
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
145R----
RKWI
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
146L----
LVM
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
147V----
LMV
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
148Q----
HQLNR
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
149L----
LMF
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
150A----
AIS
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
151G----
GNSDA
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
152A----
AHTLR
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
153P----
TPQR
PEPTIDE /note="Copeptin" /id="PRO_0000020517" PEPTIDE /note="Copeptin" /id="PRO_0000020517"
154E----
EPQS
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
155P----
PSG
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
156F----
HVARFGLS
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
157E----
QEDR
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
158P----
PVS
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
159A----
AH
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
160Q----
QKA
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
161P----
P
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
162D----
GRD
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
163A----
VGA
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"
164Y----
Y
PEPTIDE /note="Copeptin" /id="PRO_0000020517" DISORDER predicted by DISOPRED PEPTIDE /note="Copeptin" /id="PRO_0000020517"