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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
3025 967 45 P15144(AMPN_HUMAN) RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13;
QUERYSEQ 
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDI
DKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALA
SSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQ
YSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 967 8
Buired or ExposedBuried 56.6 (%) [512] 42.9 (%) [3]
Exposed 43.4 (%) [393] 57.1 (%) [4]
Ave relacc 23.5 % 33.2 %
SD relacc 24.33 % 29.62 %
Contact Molhetero 9.7 (%) [94] 25.0 (%) [2]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 10.7 (%) [103] 37.5 (%) [3]
metal 0.6 (%) [6] 0.0 (%) [0]
otherpoly 8.7 (%) [84] 37.5 (%) [3]
homo 2.7 (%) [26] 0.0 (%) [0]
precipitant 25.4 (%) [246] 37.5 (%) [3]
Number of variants 9 9
N_Freq(AAvariant)==0 % 44.4 % [4]
N_Freq(AAvariant)>0 % 55.6 % [5]
Ave Freq(AAvariant) 1.8 %
SD Freq(AAvariant) 2.44 %

Site Table for OMIM:LB/B [9 variants]

8 sites 20,86,242,243,311,321,603,752
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
20V---- 
VALQI
 TRANSMEM /note="Helical; Signal-anchor for type II membrane protein" TRANSMEM /note="Helical; Signal-anchor for type II membrane protein" DISORDER predicted by DISOPRED V->M:(0.0 %):LB/B - dbSNP:rs1015247
86REe 20.6 5lhd_C compound NAG otherpoly precipitant 
DENSKAGRQ
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" R->Q:(1.0 %):LB/B - dbSNP:rs25653
242DTe 84.6 5lhd_C hetero H1AG31_CVH22 compound NAG otherpoly 
GEDQSVKRTANPHFIL
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" D->Y:(0.0 %):LB/B -
243LSb 18.5 5lhd_C compound NAG otherpoly precipitant 
LYFAHSVEKMRTWCQ
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" L->P:(0.0 %):LB/B -
311ATe 61.6 5lhd_C hetero H1AG31_CVH22 
AEKSTDQNGHRVFILMPW
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" A->V:(2.0 %):LB/B - dbSNP:rs1724026
321THb 0.0 5lhd_C 
TAEGSILVDN
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" T->M:(0.0 %):LB/B - dbSNP:rs8179199
603I e 46.2 5lhd_C precipitant 
LVIHPSRAMEKDFG
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" I->K:(2.0 %):LB/B - dbSNP:rs1724021;I->M:(3.0 %):LB/B - dbSNP:rs8192297
752SHb 0.8 5lhd_C 
LVNAHTSEQYDGIKPR
 REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" S->N:(8.0 %):LB/B - dbSNP:rs25651