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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
14157 529 16 P52292(IMA1_HUMAN) RecName: Full=Importin subunit alpha-1 ;AltName: Full=Karyopherin subunit alpha-2;AltName: Full=RAG cohort protein 1;AltName: Full=SRP1-alpha;
QUERYSEQ 
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG
TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQA
AEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 529 4
Buired or ExposedBuried 44.6 (%) [214] 50.0 (%) [2]
Exposed 55.4 (%) [266] 50.0 (%) [2]
Ave relacc 30.8 % 35.1 %
SD relacc 28.43 % 24.17 %
Contact Molhetero 18.9 (%) [100] 50.0 (%) [2]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 0.0 (%) [0] 0.0 (%) [0]
metal 0.8 (%) [4] 0.0 (%) [0]
otherpoly 0.0 (%) [0] 0.0 (%) [0]
homo 10.0 (%) [53] 25.0 (%) [1]
precipitant 14.0 (%) [74] 25.0 (%) [1]
Number of variants 4 4
N_Freq(AAvariant)==0 % 0.0 % [0]
N_Freq(AAvariant)>0 % 100.0 % [4]
Ave Freq(AAvariant) 13.8 %
SD Freq(AAvariant) 6.42 %

Site Table for OMIM:LB/B [4 variants]

4 sites 157,165,365,453
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
157AHb 14.3 5h43_A 
AVEIQLNSPRTC
 REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" A->V:(19.0 %):LB/B - dbSNP:rs1785003
165PHe 36.4 5h43_A 
PEQSALRI
 REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" P->R:(4.0 %):LB/B - dbSNP:rs1154598
365GSb 15.5 5h43_A hetero NCBP1_HUMAN KAT8_HUMAN homo precipitant 
GSDHEANTKLP
 REGION /note="NLS binding site (minor)" REGION /note="NLS binding site (minor)" G->S:(12.0 %):LB/B - dbSNP:rs1059558
453KHe 74.1 5h43_A hetero 
KNDMAQPRVEFGILSTY
 REPEAT /note="ARM 9" REPEAT /note="ARM 9" K->N:(20.0 %):LB/B - dbSNP:rs1785003