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Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
23073 492 1500 O15393(TMPS2_HUMAN) RecName: Full=Transmembrane protease serine 2 ; EC=3.4.21.122 ;AltName: Full=Serine protease 10 ;Contains: RecName: Full=Transmembrane protease serine 2 non-catalytic chain;Contains: RecName: Full=Transmembrane protease serine 2 catalytic chain;Flags: Precursor;
QUERYSEQ 
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR
LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN
NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 492 7
Buired or ExposedBuried 45.8 (%) [174] 20.0 (%) [1]
Exposed 54.2 (%) [206] 80.0 (%) [4]
Ave relacc 29.2 % 36.7 %
SD relacc 26.85 % 21.07 %
Contact Molhetero 46.7 (%) [230] 42.9 (%) [3]
nucleotide 2.8 (%) [14] 0.0 (%) [0]
compound 35.0 (%) [172] 28.6 (%) [2]
metal 39.0 (%) [192] 42.9 (%) [3]
otherpoly 5.7 (%) [28] 0.0 (%) [0]
homo 34.6 (%) [170] 42.9 (%) [3]
precipitant 51.4 (%) [253] 42.9 (%) [3]
Number of variants 7 7
N_Freq(AAvariant)==0 % 57.1 % [4]
N_Freq(AAvariant)>0 % 42.9 % [3]
Ave Freq(AAvariant) 9.0 %
SD Freq(AAvariant) 18.09 %

Site Table for OMIM:LB/B [7 variants]

7 sites 28,74,160,254,329,449,491
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
28A---- 
LAP
 TOPO_DOM /note="Cytoplasmic" DISORDER predicted by DISOPRED TOPO_DOM /note="Cytoplasmic" A->T:(0.0 %):LB/B -
74G---- 
GW
 TOPO_DOM /note="Cytoplasmic" TOPO_DOM /note="Cytoplasmic" G->R:(0.0 %):LB/B -
160VEb 1.3 8vgt_B 
VLKACFIDEGNPQRST
 DOMAIN /note="SRCR" TOPO_DOM /note="Extracellular" DOMAIN /note="SRCR" TOPO_DOM /note="Extracellular" V->M:(0.0 %):LB/B - dbSNP:rs1232976
254S e 59.1 7wqx_A 
SGQADETFLIKNPHRV
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" S->C:(0.0 %):LB/B -
329EEe 40.7 8vgt_B hetero BPT1_BOVIN Q6VEQ7_BAUBA Q16938_ANCCA TMPSD_HUMAN compound PBZ BET metal BR homo precipitant 
EKSDRAQVTLNIPFGH
 DOMAIN /note="Peptidase S1" TOPO_DOM /note="Extracellular" DOMAIN /note="Peptidase S1" TOPO_DOM /note="Extracellular" E->Q:(5.0 %):LB/B - dbSNP:rs7751373
449KEe 26.9 8vgt_B hetero FA10_HUMAN FA7_HUMAN FA9_HUMAN PROC_HUMAN HEPS_HUMAN FA9_PIG TMPS2_HUMAN PRTC_HUMAN FA10_BOVIN TMPSD_HUMAN compound NAG XYP metal BR homo precipitant 
GKDERVNSAFHLPQYIMT
 DOMAIN /note="Peptidase S1" TOPO_DOM /note="Extracellular" DOMAIN /note="Peptidase S1" TOPO_DOM /note="Extracellular" K->N:(5.0 %):LB/B - dbSNP:rs1056602
491D e 55.6 8vgt_B hetero TMPS2_HUMAN FA7_HUMAN metal CL CD homo precipitant 
NEDAKSQR
 TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular" D->N:(53.0 %):LB/B - dbSNP:rs7798752