HOMCOS:

		Contact Molecules for Homologous Proteins
[Summary Bars]	[Full Bars]	Sites by Variants[60 %]	[Back to Search Page]	[Back to HOMCOS]
[SupCon3D]	[help]	seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100]	[show] [download] [help]

PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

29474

1170

P20701(ITAL_HUMAN)

RecName: Full=Integrin alpha-L ;AltName: Full=CD11 antigen-like family member A;AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A;AltName: Full=Leukocyte function-associated molecule 1 alpha chain;AltName: CD_antigen=CD11a;Flags: Precursor;

QUERYSEQ

MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQEC
IKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQT
IHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDI
PPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFS
LCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

		All	LB/B (likely benign or benign)
Number of sites		1170	4
Buired or Exposed	Buried	48.0 (%) [325]	0.0 (%) [0]
Buired or Exposed	Exposed	52.0 (%) [352]	100.0 (%) [2]
Ave relacc		28.6 %	52.2 %
SD relacc		27.21 %	10.72 %
Contact Mol	hetero	6.6 (%) [77]	0.0 (%) [0]
	nucleotide	0.0 (%) [0]	0.0 (%) [0]
	compound	3.2 (%) [37]	25.0 (%) [1]
	metal	2.5 (%) [29]	25.0 (%) [1]
	otherpoly	0.0 (%) [0]	0.0 (%) [0]
	homo	6.2 (%) [73]	0.0 (%) [0]
	precipitant	2.1 (%) [24]	0.0 (%) [0]
Number of variants		4	4
N_Freq(AAvariant)==0 %			50.0 % [2]
N_Freq(AAvariant)>0 %			50.0 % [2]
Ave Freq(AAvariant)			1.0 %
SD Freq(AAvariant)			1.00 %

Site Table for OMIM:LB/B [4 variants]

4 sites

144,214,746,791

  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.

n	a	s	e	acc	pdb	contact_mols	observed aa	feature table	variant
144	R		e	41.5	5e6u_A	compound NAG	RPGIKLQADSVCFH	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	R->H:(2.0 %):LB/B - dbSNP:rs3416670
214	R	T	e	62.9	5e6u_A	metal MG	KQRGSTAVINEPH	DOMAIN /note="VWFA" TOPO_DOM /note="Extracellular" DOMAIN /note="VWFA" TOPO_DOM /note="Extracellular"	R->W:(0.0 %):LB/B - dbSNP:rs1064524
746	Q	-	-	-	-		RLSEQADTFPVGIKNWCHMY	TOPO_DOM /note="Extracellular" DISORDER predicted by DISOPRED TOPO_DOM /note="Extracellular"	Q->K:(2.0 %):LB/B - dbSNP:rs3483894
791	R	-	-	-	-		KQSDPILNRCEGAV	TOPO_DOM /note="Extracellular" TOPO_DOM /note="Extracellular"	R->T:(0.0 %):LB/B - dbSNP:rs2230433

Contact Molecules for Homologous Proteins

Sites by Variants[60 %]

Statistics of sites in view of Disease classification

Site Table for OMIM:LB/B [4 variants]