[All Sites]

Contact Molecules for Homologous Proteins

[Summary Bars]
[Full Bars]


Sites by Variants[0.0 %]


[Back to Search Page]
[Back to HOMCOS]

[SupCon3D]
[help] 		seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100]
[show] [download] [help]
PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
14157 529 484 P52292(IMA1_HUMAN) RecName: Full=Importin subunit alpha-1 ;AltName: Full=Karyopherin subunit alpha-2;AltName: Full=RAG cohort protein 1;AltName: Full=SRP1-alpha;
QUERYSEQ 
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG
TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQA
AEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

Statistics of sites in view of Disease classification

All LB/B (likely benign or benign)
Number of sites 529 4
Buired or ExposedBuried 44.7 (%) [219] 50.0 (%) [2]
Exposed 55.3 (%) [271] 50.0 (%) [2]
Ave relacc 31.7 % 35.1 %
SD relacc 29.87 % 24.17 %
Contact Molhetero 63.3 (%) [335] 75.0 (%) [3]
nucleotide 0.0 (%) [0] 0.0 (%) [0]
compound 11.5 (%) [61] 0.0 (%) [0]
metal 18.5 (%) [98] 50.0 (%) [2]
otherpoly 0.0 (%) [0] 0.0 (%) [0]
homo 52.6 (%) [278] 50.0 (%) [2]
precipitant 55.0 (%) [291] 75.0 (%) [3]
Number of variants 4 4
N_Freq(AAvariant)==0 % 0.0 % [0]
N_Freq(AAvariant)>0 % 100.0 % [4]
Ave Freq(AAvariant) 13.8 %
SD Freq(AAvariant) 6.42 %

Site Table for OMIM:LB/B [4 variants]

4 sites 157,165,365,453
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
157AHb 14.3 5h43_A homo precipitant 
AVEIQLNSPRTC
 REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" A->V:(19.0 %):LB/B - dbSNP:rs1785003
165PHe 36.4 5h43_A hetero A0A2K3CMR7_CHLRE D4P3R6_CHLRE metal CL precipitant 
PEQSALRI
 REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" P->R:(4.0 %):LB/B - dbSNP:rs1154598
365GSb 15.5 5h43_A hetero RCC1_HUMAN TF7L2_HUMAN MLH1_HUMAN W_HENDH P70062_XENLA APC_HUMAN NUP2_YEAST PB2_IAVI7 VPR_HV1B9 SOX2_HUMAN TF65_HUMAN NCBP1_HUMAN DDX21_MOUSE SRC1_YEAST NCAP_I34A1 NUMA1_HUMAN KAT8_HUMAN W_NIPAV NIT2_NEUCR Q6J4H1_CHLRE T2BB21_MERS HIF1A_HUMAN metal CA homo precipitant 
GSDHEANTKLP
 REGION /note="NLS binding site (minor)" REGION /note="NLS binding site (minor)" G->S:(12.0 %):LB/B - dbSNP:rs1059558
453KHe 74.1 5h43_A hetero 
KNDMAQPRVEFGILSTY
 REPEAT /note="ARM 9" REPEAT /note="ARM 9" K->N:(20.0 %):LB/B - dbSNP:rs1785003