Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
27536 63 6 P59634(NS6_SARS) RecName: Full=ORF6 protein; Short=ORF6;AltName: Full=Accessory protein 6;AltName: Full=Non-structural protein 6; Short=ns6;AltName: Full=Protein X3;
QUERYSEQ
MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDYP
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]
  [n]:site number of query sequence.  [a]:amino acid of query sequence.  [s]:predicted secondary structure.
  [e]:predicted exposed/buried.  [acc]:predicted relative accesssibility(%).  [pdb]:PDB code of homologous structure.
  [contact_mols]:predicted binding molecules  [observed aa]:Observed amino acids among homologous sequences.  [feature table]:UniProt Feature Table
  [variant]:UniProt Human Variant.
n a s e acc pdb contact_mols observed aa feature table variant
1M----
M
2F----
F
3H----
H
4L----
L
5V----
V
6D----
D
7F----
F
8Q----
Q
9V----
V
10T----
T
11I----
I
12A----
A
13E----
E
14I----
I
15L----
L
16I----
IL
17I----
I
18I----
I
19M----
M
20R----
RK
21T----
T
22F----
F
23R----
RK
24I----
VI
25A----
AS
26I----
I
27W----
W
28N----
N
29L----
L
30D----
D
31V----
YIV
32I----
IL
33I----
I
34S----
SN
35S----
SL
36I----
I
37V----
VI
38R----
RK
39Q----
QN
40L----
L
41F----
FS
42K----
K
43P----
PS
44L----
L
45T----
T
46K----
KE
47K----
KN
48N----
NK
49Y----
Y
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression."
50S e131.2 7vpg_I
S
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression."
51E e 85.4 7vpg_I
EQ
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression."
52L e119.7 7f90_B hetero RAE1L_HUMAN
L
MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression." MUTAGEN /note="YSEL->AAAA: No effect in the suppression of nuclear gene expression."
53D e 88.9 7f90_B hetero RAE1L_HUMAN
D
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression."
54DSe 77.2 7f90_B hetero RAE1L_HUMAN
DE
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import"
55E e 95.5 7f90_B hetero RAE1L_HUMAN
E
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import"
56E e 72.4 7f90_B hetero RAE1L_HUMAN
EQ
MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="DDEE->AAAA: Reduction in the suppression of nuclear gene expression." REGION /note="Critical for disrupting nuclear import"
57P e 95.3 7f90_B hetero RAE1L_HUMAN
P
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"
58M e 75.8 7f90_B hetero RAE1L_HUMAN
M
MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import" MUTAGEN /note="M->A: Decreases down-regulation of protein expression of newly transcribed genes in the host cell. Complete loss of RAE1 binding." ECO:0000269|PubMed:35096974" REGION /note="Critical for disrupting nuclear import"
59E e 95.0 7f90_B hetero RAE1L_HUMAN NUP98_HUMAN
E
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"
60L e 74.2 7f90_B hetero RAE1L_HUMAN
LI
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"
61D e 91.4 7f90_B hetero RAE1L_HUMAN
D
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"
62Y e 84.3 7f90_B hetero RAE1L_HUMAN
Y
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"
63P e124.0 7f90_B
P
REGION /note="Critical for disrupting nuclear import" REGION /note="Critical for disrupting nuclear import"