Contact Molecules for Homologous Proteins | ||||
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seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100] | [show] [download] [help] |
PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
2587862 | 967 | 49 | P15144(AMPN_HUMAN) | RecName: Full=Aminopeptidase N ; Short=AP-N; Short=hAPN; EC=3.4.11.2 ;AltName: Full=Alanyl aminopeptidase;AltName: Full=Aminopeptidase M; Short=AP-M;AltName: Full=Microsomal aminopeptidase;AltName: Full=Myeloid plasma membrane glycoprotein CD13;AltName: Full=gp150;AltName: CD_antigen=CD13; |
QUERYSEQ |
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDI DKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALA SSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQ YSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK |
All | LB/B (likely benign or benign) | ||
Number of sites | 967 | 8 | |
Buired or Exposed | Buried | 56.6 (%) [512] | 42.9 (%) [3] |
Exposed | 43.4 (%) [393] | 57.1 (%) [4] | |
Ave relacc | 23.5 % | 33.2 % | |
SD relacc | 24.33 % | 29.62 % | |
Contact Mol | hetero | 9.7 (%) [94] | 25.0 (%) [2] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 10.7 (%) [103] | 37.5 (%) [3] | |
metal | 0.6 (%) [6] | 0.0 (%) [0] | |
otherpoly | 8.7 (%) [84] | 37.5 (%) [3] | |
homo | 2.7 (%) [26] | 0.0 (%) [0] | |
precipitant | 25.4 (%) [246] | 37.5 (%) [3] | |
Number of variants | 9 | 9 | |
N_Freq(AAvariant)==0 % | 44.4 % [4] | ||
N_Freq(AAvariant)>0 % | 55.6 % [5] | ||
Ave Freq(AAvariant) | 1.8 % | ||
SD Freq(AAvariant) | 2.44 % |
8 sites | 20,86,242,243,311,321,603,752 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
20 | V | - | - | - | - | VALQI |
TRANSMEM /note="Helical; Signal-anchor for type II membrane protein" TRANSMEM /note="Helical; Signal-anchor for type II membrane protein" DISORDER predicted by DISOPRED | V->M:(0.0 %):LB/B - dbSNP:rs1015247 | |
86 | R | E | e | 20.6 | 5lhd_C | compound NAG otherpoly precipitant | DENSKAGRQ |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | R->Q:(1.0 %):LB/B - dbSNP:rs25653 |
242 | D | T | e | 84.6 | 5lhd_C | hetero H1AG31_CVH22 compound NAG otherpoly | GEDQSVKRTANPHFIL |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | D->Y:(0.0 %):LB/B - |
243 | L | S | b | 18.5 | 5lhd_C | compound NAG otherpoly precipitant | LYFAHSVEKMRTWCQ |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | L->P:(0.0 %):LB/B - |
311 | A | T | e | 61.6 | 5lhd_C | hetero H1AG31_CVH22 | AEKSTDQNGHRVFILMPW |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | A->V:(2.0 %):LB/B - dbSNP:rs1724026 |
321 | T | H | b | 0.0 | 5lhd_C | TAEGSILVDN |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | T->M:(0.0 %):LB/B - dbSNP:rs8179199 | |
603 | I | e | 46.2 | 5lhd_C | precipitant | LVIHPSRAMEKDFG |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | I->K:(2.0 %):LB/B - dbSNP:rs1724021;I->M:(3.0 %):LB/B - dbSNP:rs8192297 | |
752 | S | H | b | 0.8 | 5lhd_C | LVNAHTSEQYDGIKPR |
REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" REGION /note="Metalloprotease" TOPO_DOM /note="Extracellular" | S->N:(8.0 %):LB/B - dbSNP:rs25651 |