Contact Molecules for Homologous Proteins | ||||
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seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100] | [show] [download] [help] |
PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
14365 | 529 | 162 | P52292(IMA1_HUMAN) | RecName: Full=Importin subunit alpha-1 ;AltName: Full=Karyopherin subunit alpha-2;AltName: Full=RAG cohort protein 1;AltName: Full=SRP1-alpha; |
QUERYSEQ |
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQA AEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF |
All | LB/B (likely benign or benign) | ||
Number of sites | 529 | 4 | |
Buired or Exposed | Buried | 44.3 (%) [217] | 50.0 (%) [2] |
Exposed | 55.7 (%) [273] | 50.0 (%) [2] | |
Ave relacc | 31.2 % | 35.1 % | |
SD relacc | 28.82 % | 24.17 % | |
Contact Mol | hetero | 29.3 (%) [155] | 50.0 (%) [2] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 8.5 (%) [45] | 0.0 (%) [0] | |
metal | 2.5 (%) [13] | 0.0 (%) [0] | |
otherpoly | 0.0 (%) [0] | 0.0 (%) [0] | |
homo | 10.0 (%) [53] | 25.0 (%) [1] | |
precipitant | 26.5 (%) [140] | 25.0 (%) [1] | |
Number of variants | 4 | 4 | |
N_Freq(AAvariant)==0 % | 0.0 % [0] | ||
N_Freq(AAvariant)>0 % | 100.0 % [4] | ||
Ave Freq(AAvariant) | 13.8 % | ||
SD Freq(AAvariant) | 6.42 % |
4 sites | 157,165,365,453 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
157 | A | H | b | 14.3 | 5h43_A | AVEIQLNSPRTC |
REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" | A->V:(19.0 %):LB/B - dbSNP:rs1785003 | |
165 | P | H | e | 36.4 | 5h43_A | PEQSALRI |
REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" REPEAT /note="ARM 3" REGION /note="NLS binding site (major)" | P->R:(4.0 %):LB/B - dbSNP:rs1154598 | |
365 | G | S | b | 15.5 | 5h43_A | hetero MLH1_HUMAN VPR_HV1B9 TF65_HUMAN NCBP1_HUMAN DDX21_MOUSE NCAP_I34A1 NUMA1_HUMAN KAT8_HUMAN NIT2_NEUCR HIF1A_HUMAN homo precipitant | GSDHEANTKLP |
REGION /note="NLS binding site (minor)" REGION /note="NLS binding site (minor)" | G->S:(12.0 %):LB/B - dbSNP:rs1059558 |
453 | K | H | e | 74.1 | 5h43_A | hetero | KNDMAQPRVEFGILSTY |
REPEAT /note="ARM 9" REPEAT /note="ARM 9" | K->N:(20.0 %):LB/B - dbSNP:rs1785003 |