Contact Molecules for Homologous Proteins | ||||
[Summary Bars] |
[Full Bars] |
|
[Back to Search Page] |
[Back to HOMCOS] |
[SupCon3D] |
[help] |
seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100] | [show] [download] [help] |
PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
676673 | 805 | 423 | Q9BYF1(ACE2_HUMAN) | RecName: Full=Angiotensin-converting enzyme 2; EC=3.4.17.23 ;AltName: Full=Angiotensin-converting enzyme homolog ; Short=ACEH ;AltName: Full=Angiotensin-converting enzyme-related carboxypeptidase ; Short=ACE-related carboxypeptidase; EC=3.4.17.- ;AltName: Full=Metalloprotease MPROT15 ;Contains: RecName: Full=Processed angiotensin-converting enzyme 2 ;Flags: Precursor; |
QUERYSEQ |
MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNE IMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTL PFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK NSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVM GVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF |
All | LB/B (likely benign or benign) | ||
Number of sites | 805 | 4 | |
Buired or Exposed | Buried | 47.2 (%) [355] | 25.0 (%) [1] |
Exposed | 52.8 (%) [397] | 75.0 (%) [3] | |
Ave relacc | 28.4 % | 45.4 % | |
SD relacc | 25.69 % | 28.96 % | |
Contact Mol | hetero | 19.3 (%) [155] | 25.0 (%) [1] |
nucleotide | 0.0 (%) [0] | 0.0 (%) [0] | |
compound | 11.6 (%) [93] | 25.0 (%) [1] | |
metal | 10.1 (%) [81] | 25.0 (%) [1] | |
otherpoly | 11.8 (%) [95] | 25.0 (%) [1] | |
homo | 8.2 (%) [66] | 25.0 (%) [1] | |
precipitant | 18.5 (%) [149] | 0.0 (%) [0] | |
Number of variants | 4 | 4 | |
N_Freq(AAvariant)==0 % | 50.0 % [2] | ||
N_Freq(AAvariant)>0 % | 50.0 % [2] | ||
Ave Freq(AAvariant) | 10.5 % | ||
SD Freq(AAvariant) | 10.52 % |
4 sites | 26,468,638,720 |
[n]:site number of query sequence. [a]:amino acid of query sequence. [s]:predicted secondary structure. [e]:predicted exposed/buried. [acc]:predicted relative accesssibility(%). [pdb]:PDB code of homologous structure. [contact_mols]:predicted binding molecules [observed aa]:Observed amino acids among homologous sequences. [feature table]:UniProt Feature Table [variant]:UniProt Human Variant.
n | a | s | e | acc | pdb | contact_mols | observed aa | feature table | variant |
26 | K | H | e | 34.4 | 7v61_B | hetero SPIKE_SARS2 compound NAG NDG metal CL otherpoly | KRSEQTVDN |
MUTAGEN /note="QAK->KAE: Slightly inhibits interaction with SARS- CoV spike glycoprotein." DOMAIN /note="Peptidase M2" TOPO_DOM /note="Extracellular" MUTAGEN /note="QAK->KAE: Slightly inhibits interaction with SARS- CoV spike glycoprotein." DOMAIN /note="Peptidase M2" TOPO_DOM /note="Extracellular" | K->R:(22.0 %):LB/B - dbSNP:rs4646116 |
468 | I | S | b | 2.9 | 7v61_B | IVTLA |
DOMAIN /note="Peptidase M2" TOPO_DOM /note="Extracellular" DOMAIN /note="Peptidase M2" TOPO_DOM /note="Extracellular" | I->V:(20.0 %):LB/B - | |
638 | N | H | e | 70.9 | 7v61_B | homo | NRD |
DOMAIN /note="Collectrin-like" TOPO_DOM /note="Extracellular" DOMAIN /note="Collectrin-like" TOPO_DOM /note="Extracellular" | N->S:(0.0 %):LB/B - dbSNP:rs1831357 |
720 | N | S | e | 73.3 | 7v61_B | NQH |
DOMAIN /note="Collectrin-like" TOPO_DOM /note="Extracellular" DOMAIN /note="Collectrin-like" TOPO_DOM /note="Extracellular" | N->D:(0.0 %):LB/B - |